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Sample records for newly discovered aerobic

  1. The Newly Discovered Rembrandt Impact Basin

    NASA Image and Video Library

    2009-05-05

    This NAC mosaic of the newly discovered Rembrandt impact basin was presented last week during a NASA media teleconference. The number per area and size distribution of impact craters superposed on Rembrandt rim indicates that it is one of the younges

  2. Michael Maier--nine newly discovered letters.

    PubMed

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony.

  3. Newly discovered insect RNA viruses in China.

    PubMed

    Qiu, Yang; Wang, ZhaoWei; Liu, YongXiang; Qi, Nan; Si, Jie; Xiang, Xue; Xia, XiaoLing; Hu, YuanYang; Zhou, Xi

    2013-08-01

    Insects are a group of arthropods and the largest group of animals on Earth, with over one million species described to date. Like other life forms, insects suffer from viruses that cause disease and death. Viruses that are pathogenic to beneficial insects cause dramatic economic losses on agriculture. In contrast, viruses that are pathogenic to insect pests can be exploited as attractive biological control agents. All of these factors have led to an explosion in the amount of research into insect viruses in recent years, generating impressive quantities of information on the molecular and cellular biology of these viruses. Due to the wide variety of insect viruses, a better understanding of these viruses will expand our overall knowledge of their virology. Here, we review studies of several newly discovered RNA insect viruses in China.

  4. A newly discovered sialidase from Gardnerella vaginalis.

    PubMed

    von Nicolai, H; Hammann, R; Salehnia, S; Zilliken, F

    1984-10-01

    A sialidase (neuraminidase, acylneuraminosyl hydrolase, EC 3.2.1.18) has been discovered and isolated from Gardnerella vaginalis (ex. Haemophilus vaginalis), a possibly pathogenic inhabitant of the female genital tract. Bacteria were grown in peptone-yeast-extract medium with 2.0 mM N-acetylmannosamine as enzyme inductor under CO2 atmosphere. Sialidase activity was found in the bacterial sediment and in the culture medium. The enzyme was liberated from the cells by ultrasonic treatment. Purification was performed by 60-80% ammonium sulfate precipitation and by column chromatography on Sepharose CL-6B and Sephadex G 200. The enzyme revealed a molecular weight in the range of Mr 75 000 and a pH optimum at 5.5. Among the different types of NeuAc-containing glycoconjugates, the enzyme exhibits its highest activities towards the globular glycoproteins alpha 1-acid glycoprotein and fetuin. Taking their cleavage rate as 100, it is around 55 for II3NeuAc-Lac, 45 for bovine submaxillary mucin, 35 for II6NeuAc-Lac and IV3, III6NeuAc2-LcOse4. The rates for III8,II3NeuAc2-Lac, gangliosides and colominic acid are below 20. Due to its specificity pattern, the enzyme may play a role in the pathogenic process of G. vaginalis infections.

  5. [Newly discovered hepatitis viruses--do they cause hepatitis indeed?].

    PubMed

    Takács, Mária; Lengyel, Anna; Dencs, Agnes; Berencsi, György

    2003-08-10

    The paper reviews the available information on the newly discovered viruses originally supposed to cause post-transfusion hepatitis. GBV-C/Hepatitis G virus belongs to the Flaviviridae family, and can be transmitted parenterally like Hepatitis C virus. Its role in causing hepatitis or other diseases has not been proved yet. The other newly discovered viruses contain single-stranded circular DNA, with a wide range of sequence divergence. These viruses can be transmitted not only with blood and blood products but via fecal-oral route as well. They are unique among enterally transmitted viruses in the sense that the virus persists for years in the human body, therefore their genomes may be detected in the blood of the healthy population in high percentage. One of the genotypes of TTV is suspected to cause hepatitis. High TT virus load was found as an independent factor associated with the occurrence of hepatocellular carcinoma among patients with hepatitis C virus-related chronic liver disease. It is not clear yet, whether TTV-like minivirus and SEN virus cause any illnesses.

  6. Serum irisin levels and thyroid function--newly discovered association.

    PubMed

    Ruchala, Marek; Zybek, Ariadna; Szczepanek-Parulska, Ewelina

    2014-10-01

    Irisin is a newly discovered adipo-myokin, which is reported to have a significant influence on the body metabolism and thermogenesis. Other influencing factors on metabolic state are thyroid hormones, which increase heat production and control the energy balance. Due to numerous similarities in action it seems imperative to explore these substances' potential mutual influence on the body. The aim of the study is to provide the first ever, according to our knowledge, evaluation of serum irisin concentrations in patients with thyroid dysfunction and its correlation with creatine kinase (CK) levels - a serum marker of muscle damage. The studied group consisted of 20 patients with newly diagnosed thyroid disorder - hyperthyroidism or hypothyroidism. Venous blood samples were analyzed for irisin, thyrotropin (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and CK serum concentrations. Patients' body mass index (BMI), body weight and muscle mass were evaluated using bioelectrical impedance analysis (BIA). Median serum irisin levels were lower in hypothyroid (117.30ng/ml) than hyperthyroid (161.95ng/ml) patients with a borderline statistical significance (p=0.0726). The negative correlation between irisin and TSH levels was demonstrated (r=-0.4924, p=0.0230), as well as the positive correlation between irisin and FT4 levels (r=0.4833, p=0.0360). The CK level was negatively correlated with irisin, FT4 and FT3 concentrations (r=-0.7272, p=0.0140; r=-0.9636, p=<0.0001; r=-0.8838, p=0.0007, respectively). The study demonstrates that irisin concentrations may vary according to the thyrometabolic state, which potentially could be related to the degree of muscle damage.

  7. Newly Discovered Clouds Found Floating High Above Milky Way

    NASA Astrophysics Data System (ADS)

    2002-10-01

    GREEN BANK, WV -- New studies with the National Science Foundation's Robert C. Byrd Green Bank Telescope (GBT) have revealed a previously unknown population of discrete hydrogen clouds in the gaseous halo that surrounds the Milky Way Galaxy. These clouds were discovered in the transition zone between the Milky Way and intergalactic space, and provide tantalizing evidence that supernova-powered "galactic fountains" continually blast superheated hydrogen gas into our Galactic suburbs. Hydrogen Clouds Graphic Artist's Rendering of the Milky Way (background) with insert showing GBT image of newly-discovered clouds of Hydrogen gas above the plane of the Galaxy. Credit: Kirk Woellert/National Science Foundation. Extending far above the star-filled disk of the Milky Way is an atmosphere, or halo, of hydrogen gas. "By studying this halo, we can learn a great deal about the processes that are going on inside our Galaxy as well as beyond its borders," said Jay Lockman, an astronomer with the National Radio Astronomy Observatory (NRAO) in Green Bank, West Virginia. "It has remained a mystery, however, how this halo formed and what has prevented gravitational forces from collapsing the gas into a thin layer long ago." Some astronomers have speculated that this gas is distributed as a diffuse mist held up by either magnetic fields or cosmic rays streaming out of the plane of the Milky Way. Others believed that it is made of innumerable long-lived hydrogen clouds bobbing up and down like balls tossed by a juggler. Early observations with other telescopes discovered that there was some neutral hydrogen gas floating far above the Galaxy's plane, but these instruments were not sensitive enough to reveal any structure or resolve questions about its origin. Lockman's studies for the first time show a clear picture of the structure of the gas. Rather than a mist, the halo is in fact full of discrete clouds, each containing 50-to-100 solar masses of hydrogen and averaging about 100

  8. Interpretation of the newly discovered submillimeter water maser

    NASA Technical Reports Server (NTRS)

    Neufeld, David A.; Melnick, Gary J.

    1990-01-01

    The 10(29)-9(36)321 GHz water maser discovered recently by Menten et al. (1990) may be pumped collisionally under a wide range of physical conditions. This range of conditions is similar but not identical to that required to excite the well-studied 22 GHz water maser. The ratio of the observed 22 GHz and 321 GHz intersteller maser luminosities can be explained by collisional excitation within the same warm, dense gas. Collisional pumping in a circumstellar envelope can account for the observed 321 GHz maser emission in the supergiant star VY CMa.

  9. E2000 + 223 - A newly discovered old nova?

    NASA Astrophysics Data System (ADS)

    Takalo, L. O.; Nousek, J. A.

    1985-06-01

    The X-ray source, E2000 + 223, serendipitously discovered by the Einstein Observatory, has been tentatively identified with an old nova shell. Spectroscopic observations of the diffuse optical counterpart show a heavily reddened continuum with bright forbidden S II emission lines at double lambda 6716, 6732. Radio observations at the VLA show a weak (about 1.2 mJy) extended radio source, with a nonthermal spectrum, concident with the optical emission. The observations can be best explained by assuming the object is an old nova which erupted sometime in the eighteenth or nineteenth century, similar to GK Per (Nova 1901) but at a distance of 1.4 kpc.

  10. E2000 + 223 - A newly discovered old nova?

    NASA Technical Reports Server (NTRS)

    Takalo, L. O.; Nousek, J. A.

    1985-01-01

    The X-ray source, E2000 + 223, serendipitously discovered by the Einstein Observatory, has been tentatively identified with an old nova shell. Spectroscopic observations of the diffuse optical counterpart show a heavily reddened continuum with bright forbidden S II emission lines at double lambda 6716, 6732. Radio observations at the VLA show a weak (about 1.2 mJy) extended radio source, with a nonthermal spectrum, concident with the optical emission. The observations can be best explained by assuming the object is an old nova which erupted sometime in the eighteenth or nineteenth century, similar to GK Per (Nova 1901) but at a distance of 1.4 kpc.

  11. NLRC5: a newly discovered MHC class I transactivator (CITA).

    PubMed

    Meissner, Torsten B; Li, Amy; Kobayashi, Koichi S

    2012-06-01

    Major histocompatibility complex (MHC) class I and class II are crucial for the function of the human adaptive immune system. An NLR protein, CIITA (MHC class II transactivator), is a master regulator of MHC class II gene expression as well as of some of the genes involved in MHC class II antigen presentation. It has recently been discovered that another member of the NLR protein family, NLRC5, transcriptionally activates MHC class I genes, and thus acts as "CITA" (MHC class I transactivator), a counterpart to CIITA. In addition to MHC class I genes, NLRC5 can induce the expression of β2M, TAP1 and LMP2, essential components of MHC class I antigen presentation. These findings indicate that NLRC5 and CIITA are transcriptional regulators that orchestrate the concerted expression of critical components in the MHC class I and MHC class II pathways, respectively.

  12. [Expedition glycocalyx. A newly discovered "Great Barrier Reef"].

    PubMed

    Chappell, D; Jacob, M; Becker, B F; Hofmann-Kiefer, K; Conzen, P; Rehm, M

    2008-10-01

    Healthy vascular endothelium is luminally coated by an endothelial glycocalyx, which interacts with the bloodstream and assumes a filter function on the vascular wall. Although this structure was discovered nearly 70 years ago, its physiological importance has been underestimated for a long time. Recent findings indicate that the glycocalyx is, in addition to the endothelial cells themselves, a main constituent part of the vascular barrier. The existence of different colloid osmotic gradients within and beneath this structure has now led to a modification of the Starling equation. In many vascular beds the interstitial space features a protein concentration similar to that of the plasma. The inwardly directed gradient, which retains water and proteins in the vascular system, is generated beneath the glycocalyx by selective protein filtration over this structure. The endothelial glycocalyx, as an additional competent vascular permeability barrier has, therefore, not only a key role for perioperative fluid and protein shifts into the interstitial space, but it seems to be intimately involved in the pathophysiology of diabetes, arteriosclerosis, sepsis and ischemia/reperfusion, especially with respect to associated vascular dysfunctions. The fragile glycocalyx can be destroyed in the course of surgery, trauma, ischemia/reperfusion and sepsis and by inflammatory mediators such as TNF-alpha, causing leukocyte adhesion, platelet aggregation and edema formation. Recent studies have shown that protecting this structure not only maintains the vascular barrier, but constitutes an important component of a rational perioperative fluid therapy.

  13. The Spy VI child: a newly discovered Neandertal infant.

    PubMed

    Crevecoeur, Isabelle; Bayle, Priscilla; Rougier, Hélène; Maureille, Bruno; Higham, Thomas; van der Plicht, Johannes; De Clerck, Nora; Semal, Patrick

    2010-12-01

    Spy cave (Jemeppe-sur-Sambre, Belgium) is reputed for the two adult Neandertal individuals discovered in situ in 1886. Recent reassessment of the Spy collections has allowed direct radiocarbon dating of these individuals. The sorting of all of the faunal collections has also led to the discovery of the remains of a Neandertal child, Spy VI. This individual is represented by two mandibular corpus fragments. The left fragment is the most complete and both sides preserve the mental foramen. Four deciduous teeth are associated with these mandibular remains: three incisors and one canine. The lower left canine (Spy 645a) conjoins with the corresponding alveolar socket in the left part of the mandible. Following extant standards, the developmental stage of the preserved teeth indicate an age at death of about one and a half years. In addition to performing a classical morphometric comparative study of the mandible and teeth, we have evaluated the dental tissue proportions using high-resolution microtomographic techniques. Our results show that Spy VI generally falls within the Neandertal range of variation. However, this specimen also exhibits particular traits, notably in the dental internal structural organization, which reveals that variation in the immature Neandertal variation is larger than what was variation currently represented by the available fossil record. These observations demonstrate the need for investigating the frequency and expression of immature Neandertal traits in fossil anterior teeth, as well as their temporal and geographic variation. Direct radiocarbon dating of the Spy VI specimen has been conducted in two different laboratories. The results of Spy VI confirm the age previously determined for the two adults, making the Spy Neandertal remains the youngest ever directly dated in northwest Europe. Copyright © 2010 Elsevier Ltd. All rights reserved.

  14. VizieR Online Data Catalog: newly discovered planets from WASP-South (Turner+, 2016)

    NASA Astrophysics Data System (ADS)

    Turner, O. D.; Anderson, D. R.; Cameron, A. Collier; Delrez, L.; Evans, D. F.; Gillon, M.; Hellier, C.; Jehin, E.; Lendl, M.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Segransan, D.; Smalley, B.; Smith, A. M. S.; Triaud, A. H. M. J.; Udry, S.; West, R. G.

    2017-02-01

    Lightcurves and radial velocity data of three newly discovered planets from the WASP-South survey. Discovery data come from the WASP-South telescope (SAAO, South Africa) with follow-up lightcurves from the TRAPPIST telescope and EulerCam on the Swiss telescope (La Silla, Chile). Radial velocity data are from the CORALIE spectrograph on the Swiss telescope. (6 data files).

  15. Molecular mechanism for eliminylation, a newly discovered post-translational modification.

    PubMed

    Ke, Zhihong; Smith, Gregory K; Zhang, Yingkai; Guo, Hua

    2011-07-27

    The newly discovered bacterial phosphothreonine lyases perform a post-translational modification of host cell signaling proteins through a novel catalytic mechanism that irreversibly removes the phosphate group from a phosphorylated threonine via β-elimination. This "eliminylation" reaction is shown by ab initio QM/MM studies to proceed via an E1cB-like pathway, in which the carbanion intermediate is stabilized by an enzyme oxyanion hole provided by Lys104 and Tyr158 of SpvC.

  16. Bubble Shuttle: A newly discovered transport mechanism, which transfers microorganisms from the sediment into the water column

    NASA Astrophysics Data System (ADS)

    Schmale, O.; Stolle, C.; Leifer, I.; Schneider von Deimling, J.; Kiesslich, K.; Krause, S.; Frahm, A.; Treude, T.

    2013-12-01

    The diversity and abundance of methanotrophic microorganisms is well studied in the aquatic environment, indicating their importance in biogeochemical cycling of methane in the sediment and the water column. However, whether methanotrophs are distinct populations in these habitats or are exchanged between benthic and pelagic environments, remains an open question. Therefore, field studies were conducted at the 'Rostocker Seep' site (Coal Oil Point seep area, California, USA) to test our hypothesis that methane-oxidizing microorganisms can be transported by gas bubbles from the sediment into the water column. The natural methane emanating location 'Rostocker Seep' showed a strong surface water oversaturation in methane with respect to the atmospheric equilibrium. Catalyzed Reporter Deposition Fluorescence In Situ Hybridization (CARD-FISH) analyzes were performed to determine the abundance of aerobic and anaerobic methanotrophic microorganisms. Aerobic methane oxidizing bacteria were detected in the sediment and the water column, whereas anaerobic methanotrophs were detected exclusively in the sediment. The key device of the project was the newly developed "Bubble Catcher" used to collect naturally emanating gas bubbles at the sea floor together with particles attached to the bubble surface rim. Bubble Catcher experiments were carried out directly above a natural bubble release spot and on a reference site at which artificially released gas bubbles were caught, which had no contact with the sediment. CARD-FISH analyzes showed that aerobic methane oxidizing bacteria were transported by gas bubbles from the sediment into the water column. In contrast anaerobic methanotrophs were not detected in the bubble catcher. Further results indicate that this newly discovered Bubble Shuttle transport mechanism might influence the distribution pattern of methanotrophic microorganisms in the water column and even at the air-sea interface. Methane seep areas are often characterized

  17. Aerobic and Anaerobic Toluene Degradation by a Newly Isolated Denitrifying Bacterium, Thauera sp. Strain DNT-1

    PubMed Central

    Shinoda, Yoshifumi; Sakai, Yasuyoshi; Uenishi, Hiroshi; Uchihashi, Yasumitsu; Hiraishi, Akira; Yukawa, Hideaki; Yurimoto, Hiroya; Kato, Nobuo

    2004-01-01

    A newly isolated denitrifying bacterium, Thauera sp. strain DNT-1, grew on toluene as the sole carbon and energy source under both aerobic and anaerobic conditions. When this strain was cultivated under oxygen-limiting conditions with nitrate, first toluene was degraded as oxygen was consumed, while later toluene was degraded as nitrate was reduced. Biochemical observations indicated that initial degradation of toluene occurred through a dioxygenase-mediated pathway and the benzylsuccinate pathway under aerobic and denitrifying conditions, respectively. Homologous genes for toluene dioxygenase (tod) and benzylsuccinate synthase (bss), which are the key enzymes in aerobic and anaerobic toluene degradation, respectively, were cloned from genomic DNA of strain DNT-1. The results of Northern blot analyses and real-time quantitative reverse transcriptase PCR suggested that transcription of both sets of genes was induced by toluene. In addition, the tod genes were induced under aerobic conditions, whereas the bss genes were induced under both aerobic and anaerobic conditions. On the basis of these results, it is concluded that strain DNT-1 modulates the expression of two different initial pathways of toluene degradation according to the availability of oxygen in the environment. PMID:15006757

  18. Anaerobic and aerobic degradation of pyridine by a newly isolated denitrifying bacterium.

    PubMed Central

    Rhee, S K; Lee, G M; Yoon, J H; Park, Y H; Bae, H S; Lee, S T

    1997-01-01

    New denitrifying bacteria that could degrade pyridine under both aerobic and anaerobic conditions were isolated from industrial wastewater. The successful enrichment and isolation of these strains required selenite as a trace element. These isolates appeared to be closely related to Azoarcus species according to the results of 16S rRNA sequence analysis. An isolated strain, pF6, metabolized pyridine through the same pathway under both aerobic and anaerobic conditions. Since pyridine induced NAD-linked glutarate-dialdehyde dehydrogenase and isocitratase activities, it is likely that the mechanism of pyridine degradation in strain pF6 involves N-C-2 ring cleavage. Strain pF6 could degrade pyridine in the presence of nitrate, nitrite, and nitrous oxide as electron acceptors. In a batch culture with 6 mM nitrate, degradation of pyridine and denitrification were not sensitively affected by the redox potential, which gradually decreased from 150 to -200 mV. In a batch culture with the nitrate concentration higher than 6 mM, nitrite transiently accumulated during denitrification significantly inhibited cell growth and pyridine degradation. Growth yield on pyridine decreased slightly under denitrifying conditions from that under aerobic conditions. Furthermore, when the pyridine concentration used was above 12 mM, the specific growth rate under denitrifying conditions was higher than that under aerobic conditions. Considering these characteristics, a newly isolated denitrifying bacterium, strain pF6, has advantages over strictly aerobic bacteria in field applications. PMID:9212408

  19. Preparation and Characterization of Newly Discovered Fibrous Aggregates of Single-Walled Carbon Nanohorns.

    PubMed

    Yuge, Ryota; Nihey, Fumiyuki; Toyama, Kiyohiko; Yudasaka, Masako

    2016-09-01

    Fibrous aggregates composed of radially assembled graphene-based single-walled nanotubules are prepared, named here as fibrous aggregates of single-walled carbon nanohorns (fib-CNHs), whose structure resembles that of chenille stems. The newly discovered fib-CNHs are 30-100 nm in diameter and 1-10 μm in length. The fib-CNHs show high dispersibility and conductivity. The fib-CNHs increase the advantages of nanocarbons in various fields. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. The newly discovered eclipsing cataclysmic star 2MASS J16211735 + 4412541 and its peculiarity

    NASA Astrophysics Data System (ADS)

    Kjurkchieva, Diana P.; Popov, Velimir A.; Vasileva, Doroteya L.; Petrov, Nikola I.

    2017-04-01

    We present our observations of the newly discovered, eclipsing cataclysmic star 2MASS J16211735 + 4412541 carried out two weeks after its outburst at the beginning of June 2016. Its main peculiarity is the big increasing of eclipse depth during outburst. We qualitatively modelled the folded light curves at quiescence and outburst in order to explain the reason for increase of the primary luminosity about two hundred times. The light curve fits revealed that such an effect can be reproduced by a flat disc whose radius and temperature are several times bigger than those of the primary at quiescence.

  1. Experimental study on the physical mechanism of coupling oscillation: a newly discovered oscillation in Hall thrusters

    NASA Astrophysics Data System (ADS)

    Yu, Da-ren; Wei, Li-qiu; Ding, Yong-jie; Han, Ke; Yan, Guo-jun; Qi, Feng-yan

    2007-11-01

    In order to study the physical mechanism of an oscillation newly discovered by the Harbin Institute of Technology Plasma Propulsion Lab (HPPL) in the range of hundreds of kHz to several MHz, Hall thrusters with different magnetic coils are studied by changing one of the following three parameters: discharge voltage, anode flow and coil current, directly measuring the coil current and measuring plasma oscillations related to coil current oscillation with the Langmuir probe. Experimental results indicated that in the discharge process of a Hall thruster the broadband turbulence of the Hall current causes an unstable spatial magnetic field and this field causes the magnetic circuit to resonate as an equivalent high level resistance-inductance-capacitance (RLC) network. As the response of the network, the oscillation of the coil current has a large oscillating component at the natural frequencies of the network. Also, the oscillation of coil current has an effect on the discharge process at the same time, so that they reach a self-consistent equilibrium state. As a result of such a coupling, both coil current and the discharge current exhibit their oscillating component at the natural frequencies of the magnetic circuit. It is therefore concluded that the newly discovered oscillation is caused by the coupling between the magnetic circuit and the discharge circuit.

  2. Examining the diversity and distribution of microbial communities from newly discovered methane seeps along the Cascadia Margin

    NASA Astrophysics Data System (ADS)

    Seabrook, S.; Thurber, A. R.; Embley, R. W.; Raineault, N.; Baumberger, T.; Merle, S. G.

    2016-12-01

    Methane seeps provide biogeochemical and microbial heterogeneity in deep-sea habitats. In June of 2016 the E/V Nautilus, exploring for methane seeps along the Cascadia continental margin, discovered over 450 bubble streams, indicative of active seepage, and collected biological samples at 6 of the resulting newly discovered seeps. These seeps covered a range of depths, latitudes, habitat types and biogeochemical environments and included: Juan de Fuca (150m), Astoria canyon (800m and 500m), Nehalem Bank (185m), Heceta SW (1200m), SW Coquille Bank (600m), and Klamath Knoll seep (700m). Geologic environment types included continental shelf, canyons and slopes, and these sites spanned the zone of hydrate stability and the Oxygen Minimum Zone. A range of seep-specific habitat were found and sampled including: reduced sediments, microbial mats, methane hydrates, clam beds (Calyptogena spp.), Siboglinidae tubeworm assemblages and sparse assemblages of stalked barnacles. Here, we present an initial characterization of the microbial communities collected via push cores by a remotely operated vehicle (ROV) at the six aforementioned sites. With high throughput amplicon sequencing of the V4-V5 region of the 16S rRNA gene, we characterize the diversity and microbial composition of the seep sites sampled. This characterization is furthered with digital drop PCR of the pmoA gene (involved with aerobic methanotrophy) to allow for a comparison of the community composition with functional gene abundance of critical microbial processes. These data will be placed in the greater biogeochemical context of the region, including direct comparison with paired gas-tight sampling at key locations. The results of these analyses will provide the first microbial description of this broad range of seep ecosystems along the Cascadia Margin adding to our overall understanding of microbial diversity, the dominant physiological processes at seep ecosystems, and the connection between community

  3. HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene.

    PubMed

    Birger, Y; Ito, Y; West, K L; Landsman, D; Bustin, M

    2001-05-01

    We describe a newly discovered nuclear protein, HMGN4, that is closely related to the canonical HMGN2 nucleosome-binding protein. The protein is encoded by an intronless gene, which, in humans, is located in the hereditary hemochromatosis [correction of hemachromatosis] region at position 6p21.3. A single approximately 2-kb HMGN4 mRNA was found to be expressed, in variable amounts, in all human tissues tested; however, the HMGN4 transcript was significantly less abundant than that of HMGN2. The HMGN4 protein could be detected in HeLa cells by Western analysis with an antibody elicited against a unique region of the protein. Transfection of HeLa cells with a plasmid expressing HMGN4-GFP indicated that the protein localizes to the nucleus. Our results expand the multiplicity of the HMGN protein family and increase the known cellular repertoire of nucleosome-binding proteins.

  4. Newly discovered Neanderthal remains from Shanidar Cave, Iraqi Kurdistan, and their attribution to Shanidar 5.

    PubMed

    Pomeroy, Emma; Mirazón Lahr, Marta; Crivellaro, Federica; Farr, Lucy; Reynolds, Tim; Hunt, Chris O; Barker, Graeme

    2017-10-01

    The Neanderthal remains from Shanidar Cave, excavated between 1951 and 1960, have played a central role in debates concerning diverse aspects of Neanderthal morphology and behavior. In 2015 and 2016, renewed excavations at the site uncovered hominin remains from the immediate area where the partial skeleton of Shanidar 5 was found in 1960. Shanidar 5 was a robust adult male estimated to have been aged over 40 years at the time of death. Comparisons of photographs from the previous and recent excavations indicate that the old and new remains were directly adjacent to one another, while the disturbed arrangement and partial crushing of the new fossils is consistent with descriptions and photographs of the older discoveries. The newly discovered bones include fragments of several vertebrae, a left hamate, part of the proximal left femur, a heavily crushed partial pelvis, and the distal half of the right tibia and fibula and associated talus and navicular. All these elements were previously missing from Shanidar 5, and morphological and metric data are consistent with the new elements belonging to this individual. A newly discovered partial left pubic symphysis indicates an age at death of 40-50 years, also consistent with the age of Shanidar 5 estimated previously. Thus, the combined evidence strongly suggests that the new finds can be attributed to Shanidar 5. Ongoing analyses of associated samples, including for sediment morphology, palynology, and dating, will therefore offer new evidence as to how this individual was deposited in the cave and permit new analyses of the skeleton itself and broader discussion of Neanderthal morphology and variation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Naphthoquinone spiroketal with allelochemical activity from the newly discovered endophytic fungus Edenia gomezpompae.

    PubMed

    Macías-Rubalcava, Martha L; Hernández-Bautista, Blanca E; Jiménez-Estrada, Manuel; González, María C; Glenn, Anthony E; Hanlin, Richard T; Hernández-Ortega, Simón; Saucedo-García, Aurora; Muria-González, Jordi M; Anaya, Ana Luisa

    2008-03-01

    Chemical investigation of the mycelium of Edenia gomezpompae, a newly discovered endophytic fungus isolated from the leaves of Callicarpa acuminata (Verbenaceae) collected from the ecological reserve El Eden, Quintana Roo, Mexico, resulted in the isolation of four naphthoquinone spiroketals, including three new compounds and palmarumycin CP2 (4). We elucidated the structures of the metabolites by extensive NMR spectroscopy studies, including DEPT, COSY, NOESY, HSQC, HMBC, and chiroptical methods. The trivial names proposed for these compounds are preussomerin EG1 (1), preussomerin EG2 (2) and preussomerin EG3 (3). In addition, the X-ray data for 4 were obtained. The bioactivity of the mycelial organic extracts and the pure compounds was tested against three endophytic fungi (Colletotrichum sp., Phomopsis sp., and Guignardia manguifera) isolated from the same plant species (C. acuminata, Verbenaceae) and against four economically important phytopathogenic microorganisms (two fungoid oomycetes, Phythophtora capsici and Phythophtora parasitica, and the fungi Fusarium oxysporum and Alternaria solani). Spiroketals 1-3 displayed significant growth inhibition against all the phytopathogens. IC50 values for the four phytopathogens were from 20 to 170 microg/ml. Palmarumycin CP2 (4) was not bioactive against any of the fungi tested. Compound 1 showed the strongest bioactivity. The acetylated derivatives of preussomerin EG1 (1), 1a and 1b, were obtained and their biological activity was tested on endophytes and phytopathogens. Preussomerin EG1 1, 1a and 1b exhibited significant bioactivity against all microorganisms tested with the exception of Alternaria solani. This is the first report of allelochemicals with antifungal activity from the newly discovered endophytic fungus E. gomezpompae.

  6. SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms

    PubMed Central

    Chelala, Claude; Khan, Arshad; Lemoine, Nicholas R

    2009-01-01

    Motivation: Design a new computational tool allowing scientists to functionally annotate newly discovered and public domain single nucleotide polymorphisms in order to help in prioritizing targets in further disease studies and large-scale genotyping projects. Summary: SNPnexus database provides functional annotation for both novel and public SNPs. Possible effects on the transcriptome and proteome levels are characterized and reported from five major annotation systems providing the most extensive information on alternative splicing. Additional information on HapMap genotype and allele frequency, overlaps with potential regulatory elements or structural variations as well as related genetic diseases can be also retrieved. The SNPnexus database has a user-friendly web interface, providing single or batch query options using SNP identifiers from dbSNP as well as genomic location on clones, contigs or chromosomes. Therefore, SNPnexus is the only database currently providing a complete set of functional annotations of SNPs in public databases and newly detected from sequencing projects. Hence, we describe SNPnexus, provide details of the query options, the annotation categories as well as biological examples of use. Availability: The SNPnexus database is freely available at http://www.snp-nexus.org. Contact: claude.chelala@cancer.org.uk PMID:19098027

  7. Scout: short-arc orbit analysis and hazard assessment for newly discovered asteroids

    NASA Astrophysics Data System (ADS)

    Farnocchia, Davide; Chesley, Steven R.; Micheli, Marco

    2016-05-01

    It typically takes a few days for a newly discovered asteroid to be officially recognized as a real object. This time is needed to collect additional data and make sure the observations belong to an actual asteroid rather than being an artifact or corresponding to an artificial object. However, asteroids could experience an Earth close approach or even an impact only a few days or less after the discovery observations, as in the cases of 2008 TC3 and 2014 AA, i.e., the only two asteroids discovered before an Earth impact. In such cases, a rapid identification of the close approach or impact dramatically improves the chances of securing the asteroid's trajectory with additional observations prior to impact. Scout is an automated system that provides an orbital and hazard assessment for new potential asteroid discoveries within minutes after the observations are available. Since the time interval covered by the observations is generally short, perhaps only a few hours or even less, there are severe degeneracies in the orbit estimation process. To overcome these degeneracies Scout relies on systematic ranging, a technique that scans the poorly constrained space of topocentric range and range rate, while the plane-of-sky position and motion are directly tied to the recorded observations. This scan allows us to identify the possible orbits and the regions corresponding to collision solutions, as well as potential impact times and locations. From the probability distribution of the observation errors, Scout derives a probability distribution in the orbital space and in turn estimates several metrics of interest, e.g., probability of an Earth impact, of a close approach to Earth, and of being a mission-accessible target.

  8. First Photometric Investigation of the Newly Discovered W UMa-type Binary Star MR Com

    NASA Astrophysics Data System (ADS)

    Qian, S.-B.; Liu, N.-P.; Liao, W.-P.; He, J.-J.; Liu, L.; Zhu, L.-Y.; Wang, J.-J.; Zhao, E.-G.

    2013-08-01

    By analyzing multi-color light curves of the newly discovered W UMa-type binary, MR Com, we discovered that it is a shallow-contact binary with a degree of contact factor of f = 10.0% ± 2.1%. Photometric solutions reveal that MR Com is a W-type system with a mass ratio of q = 3.9 where the less massive component is about 90 K hotter than the more massive one. By investigating all of the available times of minimum light, we found that the general trend of the Observed-Calculated (O - C) curve shows a downward parabolic variation while it undergoes a cyclic variation with a small amplitude of 0.0031 days and a period of 10.1 yr. The downward parabolic change corresponds to a long-term decrease in the orbital period at a rate of \\dot{P}=-5.3\\times {10^{-7}} days yr-1 that may be caused by a combination of a mass transfer and an angular momentum loss (AML) via magnetic braking. Among the 16 shallow-contact systems with a decreasing orbital period, MR Com has the lowest mass ratio (e.g., 1/q = 0.26). The shallow-contact configuration, the low-mass ratio, and the long-term period decrease all suggest that systems similar to MR Com are on the AML-controlled stage of the evolutionary scheme proposed by Qian. They will oscillate around a critical mass ratio and evolve into a deep contact with a higher mass ratio. The small-amplitude cyclic change in the O - C curve was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

  9. FIRST PHOTOMETRIC INVESTIGATION OF THE NEWLY DISCOVERED W UMa-TYPE BINARY STAR MR Com

    SciTech Connect

    Qian, S.-B.; Liu, N.-P.; Liao, W.-P.; He, J.-J.; Liu, L.; Zhu, L.-Y.; Wang, J.-J.; Zhao, E.-G.

    2013-08-01

    By analyzing multi-color light curves of the newly discovered W UMa-type binary, MR Com, we discovered that it is a shallow-contact binary with a degree of contact factor of f = 10.0% {+-} 2.1%. Photometric solutions reveal that MR Com is a W-type system with a mass ratio of q = 3.9 where the less massive component is about 90 K hotter than the more massive one. By investigating all of the available times of minimum light, we found that the general trend of the Observed-Calculated (O - C) curve shows a downward parabolic variation while it undergoes a cyclic variation with a small amplitude of 0.0031 days and a period of 10.1 yr. The downward parabolic change corresponds to a long-term decrease in the orbital period at a rate of P-dot = -5.3 x 10{sup -7} days yr{sup -1} that may be caused by a combination of a mass transfer and an angular momentum loss (AML) via magnetic braking. Among the 16 shallow-contact systems with a decreasing orbital period, MR Com has the lowest mass ratio (e.g., 1/q = 0.26). The shallow-contact configuration, the low-mass ratio, and the long-term period decrease all suggest that systems similar to MR Com are on the AML-controlled stage of the evolutionary scheme proposed by Qian. They will oscillate around a critical mass ratio and evolve into a deep contact with a higher mass ratio. The small-amplitude cyclic change in the O - C curve was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

  10. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer

    PubMed Central

    Samal, Sabindra K.; Routray, Samapika; Veeramachaneni, Ganesh Kumar; Dash, Rupesh; Botlagunta, Mahendran

    2015-01-01

    DDX3 belongs to DEAD box RNA helicase family and is involved in the progression of several types of cancer. In this work, we employed a High Throughput Virtual screening approach to identify bioactive compounds against DDX3 from ZINC natural database. Ketorolac salt was selected based on its binding free energy less than or equals to −5 Kcal/mol with reference to existing synthetic DDX3 inhibitors and strong hydrogen bond interactions as similar to crystallized DDX3 protein (2I4I). The anti-cancer activity of Ketorolac salt against DDX3 was tested using oral squamous cell carcinoma (OSCC) cell lines. This compound significantly down regulated the expression of DDX3 in human OSCC line (H357) and the half maximal growth inhibitory concentration (IC50) of Ketorolac salt in H357 cell line is 2.6 µM. Ketorolac salt also inhibited the ATP hydrolysis by directly interacting with DDX3. More importantly, we observed decreased number of neoplastic tongue lesions and reduced lesion severity in Ketorolac salt treated groups in a carcinogen induced tongue tumor mouse model. Taken together, our result demonstrates that Ketorolac salt is a newly discovered bioactive compound against DDX3 and this compound can be used as an ideal drug candidate to treat DDX3 associated oral cancer. PMID:25918862

  11. A Newly Discovered Epidemic Area of Echinococcus multilocularis in West Gansu Province in China

    PubMed Central

    Han, Jian; Bao, Genshu; Zhang, Duoqiang; Gao, Pengcheng; Wu, Tinjun; Craig, Philip; Giraudoux, Patrick; Chen, Xiao; Xin, Qi; He, Lili; Chen, Gen; Jing, Tao

    2015-01-01

    Alveolar echinococcosis (AE) is a lethal parasitic disease. In Gansu Province of China, all AE cases reported in literature were from Zhang and Min Counties, the southern part of the province. Here, we report the discovery of nine AE cases and one cystic echinococcosis (CE) case from Nanfeng Town of Minle County, in the middle of Hexi Corridor in west Gansu Province. The diagnosis of these cases were confirmed by serology, histopathology, computed tomography, B-ultrasound, immunohistochemistry method, DNA polymerase chain reaction and sequencing analysis. Because eight of nine AE cases came from First Zhanglianzhuang (FZLZ) village, we conducted preliminary epidemiological analyses of 730 persons on domestic water, community and ecology such as 356 dogs’ faeces of FZLZ, in comparison with those of other five villages surrounding FZLZ. Our studies indicate that Nanfeng Town of Minle County is a newly discovered focus of AE in China as a CE and AE co-epidemic area. Further research of Echinococcus multilocularis transmission pattern in the area should be carried for prevention of this parasitic disease. PMID:26186219

  12. Tsunamigenic potential of a newly discovered active fault zone in the outer Messina Strait, Southern Italy

    NASA Astrophysics Data System (ADS)

    Fu, Lili; Heidarzadeh, Mohammad; Cukur, Deniz; Chiocci, Francesco L.; Ridente, Domenico; Gross, Felix; Bialas, Jörg; Krastel, Sebastian

    2017-03-01

    The 1908 Messina tsunami was the most catastrophic tsunami hitting the coastline of Southern Italy in the younger past. The source of this tsunami, however, is still heavily debated, and both rupture along a fault and a slope failure have been postulated as potential origin of the tsunami. Here we report a newly discovered active Fiumefreddo-Melito di Porto Salvo Fault Zone (F-MPS_FZ), which is located in the outer Messina Strait in a proposed landslide source area of the 1908 Messina tsunami. Tsunami modeling showed that this fault zone would produce devastating tsunamis by assuming slip amounts of ≥5 m. An assumed slip of up to 17 m could even generate a tsunami comparable to the 1908 Messina tsunami, but we do not consider the F-MPS_FZ as a source for the 1908 Messina tsunami because its E-W strike contradicts seismological observations of the 1908 Messina earthquake. Future researches on the F-MPS_FZ, however, may contribute to the tsunami risk assessment in the Messina Strait.

  13. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer.

    PubMed

    Samal, Sabindra K; Routray, Samapika; Veeramachaneni, Ganesh Kumar; Dash, Rupesh; Botlagunta, Mahendran

    2015-04-28

    DDX3 belongs to DEAD box RNA helicase family and is involved in the progression of several types of cancer. In this work, we employed a High Throughput Virtual screening approach to identify bioactive compounds against DDX3 from ZINC natural database. Ketorolac salt was selected based on its binding free energy less than or equals to -5 Kcal/mol with reference to existing synthetic DDX3 inhibitors and strong hydrogen bond interactions as similar to crystallized DDX3 protein (2I4I). The anti-cancer activity of Ketorolac salt against DDX3 was tested using oral squamous cell carcinoma (OSCC) cell lines. This compound significantly down regulated the expression of DDX3 in human OSCC line (H357) and the half maximal growth inhibitory concentration (IC50) of Ketorolac salt in H357 cell line is 2.6 µM. Ketorolac salt also inhibited the ATP hydrolysis by directly interacting with DDX3. More importantly, we observed decreased number of neoplastic tongue lesions and reduced lesion severity in Ketorolac salt treated groups in a carcinogen induced tongue tumor mouse model. Taken together, our result demonstrates that Ketorolac salt is a newly discovered bioactive compound against DDX3 and this compound can be used as an ideal drug candidate to treat DDX3 associated oral cancer.

  14. A Newly Discovered Epidemic Area of Echinococcus multilocularis in West Gansu Province in China.

    PubMed

    Han, Jian; Bao, Genshu; Zhang, Duoqiang; Gao, Pengcheng; Wu, Tinjun; Craig, Philip; Giraudoux, Patrick; Chen, Xiao; Xin, Qi; He, Lili; Chen, Gen; Jing, Tao

    2015-01-01

    Alveolar echinococcosis (AE) is a lethal parasitic disease. In Gansu Province of China, all AE cases reported in literature were from Zhang and Min Counties, the southern part of the province. Here, we report the discovery of nine AE cases and one cystic echinococcosis (CE) case from Nanfeng Town of Minle County, in the middle of Hexi Corridor in west Gansu Province. The diagnosis of these cases were confirmed by serology, histopathology, computed tomography, B-ultrasound, immunohistochemistry method, DNA polymerase chain reaction and sequencing analysis. Because eight of nine AE cases came from First Zhanglianzhuang (FZLZ) village, we conducted preliminary epidemiological analyses of 730 persons on domestic water, community and ecology such as 356 dogs' faeces of FZLZ, in comparison with those of other five villages surrounding FZLZ. Our studies indicate that Nanfeng Town of Minle County is a newly discovered focus of AE in China as a CE and AE co-epidemic area. Further research of Echinococcus multilocularis transmission pattern in the area should be carried for prevention of this parasitic disease.

  15. Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda

    PubMed Central

    Towner, Jonathan S.; Sealy, Tara K.; Khristova, Marina L.; Albariño, César G.; Conlan, Sean; Reeder, Serena A.; Quan, Phenix-Lan; Lipkin, W. Ian; Downing, Robert; Tappero, Jordan W.; Okware, Samuel; Lutwama, Julius; Bakamutumaho, Barnabas; Kayiwa, John; Comer, James A.; Rollin, Pierre E.; Ksiazek, Thomas G.; Nichol, Stuart T.

    2008-01-01

    Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed random-primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines. PMID:19023410

  16. Chapare Virus, a Newly Discovered Arenavirus Isolated from a Fatal Hemorrhagic Fever Case in Bolivia

    PubMed Central

    Delgado, Simon; Erickson, Bobbie R.; Agudo, Roberto; Blair, Patrick J.; Vallejo, Efrain; Albariño, César G.; Vargas, Jorge; Comer, James A.; Rollin, Pierre E.; Ksiazek, Thomas G.; Olson, James G.; Nichol, Stuart T.

    2008-01-01

    A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and vomiting with subsequent deterioration and multiple hemorrhagic signs. A non-cytopathic virus was isolated from two of the patient serum samples, and identified as an arenavirus by IFA staining with a rabbit polyvalent antiserum raised against South American arenaviruses known to be associated with HF (Guanarito, Machupo, and Sabiá). RT-PCR analysis and subsequent analysis of the complete virus S and L RNA segment sequences identified the virus as a member of the New World Clade B arenaviruses, which includes all the pathogenic South American arenaviruses. The virus was shown to be most closely related to Sabiá virus, but with 26% and 30% nucleotide difference in the S and L segments, and 26%, 28%, 15% and 22% amino acid differences for the L, Z, N, and GP proteins, respectively, indicating the virus represents a newly discovered arenavirus, for which we propose the name Chapare virus. In conclusion, two different arenaviruses, Machupo and Chapare, can be associated with severe HF cases in Bolivia. PMID:18421377

  17. Indication of Gamma-Ray Emission from the Newly Discovered Dwarf Galaxy Reticulum II.

    PubMed

    Geringer-Sameth, Alex; Walker, Matthew G; Koushiappas, Savvas M; Koposov, Sergey E; Belokurov, Vasily; Torrealba, Gabriel; Evans, N Wyn

    2015-08-21

    We present a search for γ-ray emission from the direction of the newly discovered dwarf galaxy Reticulum II. Using Fermi-LAT Collaboration data, we detect a signal that exceeds expected backgrounds between ∼2-10  GeV and is consistent with annihilation of dark matter for particle masses less than a few ×10^{2}  GeV. Modeling the background as a Poisson process based on Fermi-LAT diffuse models, and taking into account trial factors, we detect emission with p value less than 9.8×10^{-5} (>3.7σ). An alternative, model-independent treatment of the background reduces the significance, raising the p value to 9.7×10^{-3} (2.3σ). Even in this case, however, Reticulum II has the most significant γ-ray signal of any known dwarf galaxy. If Reticulum II has a dark-matter halo that is similar to those inferred for other nearby dwarfs, the signal is consistent with the s-wave relic abundance cross section for annihilation.

  18. Newly discovered reefs in the southern Abrolhos Bank, Brazil: Anthropogenic impacts and urgent conservation needs.

    PubMed

    Mazzei, E F; Bertoncini, A A; Pinheiro, H T; Machado, L F; Vilar, C C; Guabiroba, H C; Costa, T J F; Bueno, L S; Santos, L N; Francini-Filho, R B; Hostim-Silva, M; Joyeux, J-C

    2017-01-15

    The Abrolhos Bank is an area of high ecological, socio-economic importance and harbour the richest and most-extensive coral reefs in the South Atlantic. Here we report the discovery of shallow (12-25m depth) reef complex with ten large biogenic structures, intermediate between the typical mushroom-shaped pinnacles of the northern Abrolhos Bank (17°-18° S) and the small patch reefs found on the central/southern coast of the Espírito Santo State (19°-20° S). The newly discovered reefs harbour a relatively rich and abundant reef community, with 73 fish and 14 benthic cnidarian species, including endangered and commercially important ones. We discuss on urgent needs of properly mapping and understanding the ecological functioning of this reef system. Information provided here is a baseline for future impact evaluations, particularly considering the recent worst environmental disaster of Brazil from a dam collapse in Doce river that affected the region. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Adequate levothyroxine doses for the treatment of hypothyroidism newly discovered during pregnancy.

    PubMed

    Abalovich, Marcos; Vázquez, Adriana; Alcaraz, Graciela; Kitaigrodsky, Ariela; Szuman, Gabriela; Calabrese, Cristina; Astarita, Graciela; Frydman, Mario; Gutiérrez, Silvia

    2013-11-01

    Recent guidelines recommend thyrotropin (TSH) target levels of ≤2.5 mIU/L for the first trimester and ≤3 mIU/L for the subsequent trimesters. Euthyroidism should be attained as soon as possible, but there are no precise indications about the initial levothyrorine (LT4) dose. The aim of our study was to determine the appropriate LT4 doses in order to normalize TSH levels in patients with newly discovered subclinical hypothyroidism (SCH) during pregnancy, and to correlate them with basal TSH levels. The adequate LT4 doses for women with SCH were also compared to those required in pregnant women with overt hypothyroidism (OH). Seventy-seven patients with newly diagnosed hypothyroidism during pregnancy were retrospectively analyzed. Patients were assigned to group 1 (n = 64) with SCH or group 2 (n = 13) with OH. SCH patients were subdivided into two groups: group 1a serum TSH >2.5 (1st trimester) or >3 (2nd or 3rd trimester) to 4.2 mIU/L; and group 1b TSH level > 4.21-10 mIU/L. All patients were treated with LT4 as soon as hypothyroidism was diagnosed. The dose that allowed a TSH of ≤2.5 mIU/L to be reached in the first trimester or one that allowed a TSH of ≤3 mIU/L to be reached during the second and third trimesters was considered the appropriate one. A significant difference (p < 0.0001) in the appropriate LT4 dose (mean ± SD, μg/kg/day) was observed between group 1 and group 2: 1.31 ± 0.36 versus 2.33 ± 0.59. Patients in group 1a required a significantly lower LT4 dose (p < 0.014) than group1b: 1.20 ± 0.39 versus 1.42 ± 0.31 μg/kg/day. In 57 of the 64 (89.06%) women with SCH and in 10/13 (76.92%) women with OH, the appropriate LT4 dose coincided with the initial dose. Only 11% and 23% respectively required additional adjustments. Once the appropriate dose of LT4 was prescribed, the time at which euthyroidism (mean ± SD, weeks) was confirmed was similar in patients with SCH (6.06 ± 3.3) and OH (5.3 ± 1.8). There were no

  20. 2MASS J22560844+5954299: the newly discovered cataclysmic star with the deepest eclipse

    NASA Astrophysics Data System (ADS)

    Kjurkchieva, D.; Khruzina, T.; Dimitrov, D.; Groebel, R.; Ibryamov, S.; Nikolov, G.

    2015-12-01

    Context. The SW Sex stars are assumed to represent a distinguished stage in cataclysmic variable (CV) evolution, making it especially important to study them. Aims: We discovered a new cataclysmic star and carried out prolonged and precise photometric observations, as well as medium-resolution spectral observations. Modelling these data allowed us to determine the physical parameters and to establish its peculiarities. Methods: To obtain a light curve solution we used model whose emission sources are a white dwarf surrounded by an accretion disk with a hot spot, a gaseous stream near the disk's lateral side, and a secondary star filling its Roche lobe. The obtained physical parameters are compared with those of other SW Sex-subtype stars. Results: The newly discovered cataclysmic variable 2MASS J22560844+5954299 shows the deepest eclipse amongst the known nova-like stars. It was reproduced by totally covering a very luminous accretion disk by a red secondary component. The temperature distribution of the disk is flatter than that of steady-state disk. The target is unusual with the combination of a low mass ratio q ~ 1.0 (considerably below the limit q = 1.2 of stable mass transfer of CVs) and an M-star secondary. The intensity of the observed three emission lines, Hα, He 5875, and He 6678, sharply increases around phase 0.0, accompanied by a Doppler jump to the shorter wavelength. The absence of eclipses of the emission lines and their single-peaked profiles means that they originate mainly in a vertically extended hot-spot halo. The emission Hα line reveals S-wave wavelength shifts with semi-amplitude of around 210 km s-1 and phase lag of 0.03. Conclusions: The non-steady-state emission of the luminous accretion disk of 2MASS J22560844+5954299 was attributed to the low viscosity of the disk matter caused by its unusually high temperature. The star shows all spectral properties of an SW Sex variable apart from the 0.5 central absorption. Based on data collected

  1. Merkel Cell Polyomavirus: A Newly Discovered Human Virus with Oncogenic Potential

    PubMed Central

    Spurgeon, Megan E.; Lambert, Paul F.

    2012-01-01

    A marked escalation in the rate of discovery of new types of human polyomavirus has occurred over the last five years largely owing to recent technological advances in their detection. Among the newly discovered viruses, Merkel Cell Polyomavirus (MCPyV or MCV) has gained the most attention due to its link with a rare human cancer. Infection with MCPyV is common in the human population, and the virus is detected in several anatomical locations, but most frequently in skin. Study of MCPyV molecular virology has been complicated by the lack of straightforward cell culture models, but recent in vitro studies are making strides towards understanding the virus life cycle, its cellular tropism, and mode of transmission. While MCPyV shares several traditional traits with other human polyomaviruses, the burst of research since its discovery reveals insight into a virus with many unique genetic and mechanistic features. The evidence for a causal link between MCPyV and the rare neuroendocrine cancer, Merkel Cell Carcinoma (MCC), is compelling. A majority of MCCs contain clonally integrated viral DNA, express viral T antigen transcripts and protein, and exhibit an addiction to the viral large T and small t antigen oncoproteins. The MCPyV large T antigen contains MCC tumor-specific mutations that ablate its replication capacity but preserve its oncogenic functions, and the small t antigen promotes an environment favorable for cap-dependent translation. The mechanisms of MCPyV-induced transformation have not been fully elucidated, but the likely etiological role of this new polyomavirus in human cancer provides a strong opportunity to expand knowledge of virus-host interactions and viral oncology. PMID:23217622

  2. A newly discovered arabinoxylan-specific arabinofuranohydrolase. Synergistic action with xylanases from different glycosyl hydrolase families.

    PubMed

    Valls, Adrià; Diaz, Pilar; Pastor, F I Javier; Valenzuela, Susana V

    2016-02-01

    Arabinofuranosidase Abf43A from Bacillussp. BP-7 i s a newly discovered arabinoxylan arabinofuranohydrolase (AXH). It is a modular enzyme comprised of a GH43 catalytic domain and a carbohydrate-binding module of family CBM6. Recombinant Abf43A showed high activity on arabinoxylans, being rye arabinoxylan the preferred substrate on which the purified enzyme exhibited a Km of 10.6 ± 3.3 mg/ml and a Vmax of 29.2 ± 3.4 U/mg. Thin-layer chromatography analysis of hydrolysis products showed arabinose as the only sugar released by the enzyme from its substrates. The GH43 and CBM6 modules of the enzyme were individually cloned and expressed in Escherichia coli. While the isolated catalytic GH43 module did not show hydrolytic activity, the purified CBM6 bound to soluble arabinoxylan in affinity gel electrophoresis analysis. Evaluation of cooperative activity of arabinofuranosidase Abf43A with xylanases from families GH10, GH11, andGH30, (Xyn10A, Xyn11E, and Xyn30D from Paenibacillus barcinonensis) on arabinoxylan depolymerization revealed that the studied enzyme showed synergism with Xyn11E, a 2.54-fold increase in the amount of sugars released. On the contrary, Abf43A did not show synergism with the xylanases of families GH10 or GH30 evaluated. The enzyme characterized contributes to understanding the role of this class of enzymes in the catalytic depolymerization of arabinoxylans and their potential for the production of valuable xylooligosaccharides from these abundant plant polymers.

  3. Activation of the newly discovered cyclostome renin-angiotensin system in the river lamprey Lampetra fluviatilis.

    PubMed

    Brown, J Anne; Cobb, Christopher S; Frankling, Susan C; Rankin, J Cliff

    2005-01-01

    This study describes the first investigations of the physiological signals involved in activating the newly discovered cyclostome renin-angiotensin system (RAS) and its role in the river lamprey Lampetra fluviatilis. Experimental manipulation showed that volume depletion (removal of 40% blood volume) rapidly activated the RAS of lampreys acclimated to water at 576 mOsm kg(-1) (21 p.p.t.), significantly increasing plasma angiotensin concentrations after 30 min and 60 min. In agreement with these results, a rapid change in environmental salinity (758 mOsm kg(-1) to freshwater (FW) and FW to 605 mOsm kg(-1)), resulted in a rapid decrease and increase in plasma [angiotensin], respectively. Intraperitoneal (i.p.) injection of FW-acclimated river lampreys with 1% body mass by volume of nominally isosmotic saline (120 mmol l(-1) NaCl; 233 mOsm kg(-1)) resulted in a significant decrease in the plasma angiotensin concentration within 15 min. In contrast, i.p. injection of hyperosmotic saline (4 mol l(-1) NaCl) at 1% body mass by volume, which significantly increased plasma osmolality, had no significant effect on plasma [angiotensin], suggesting that volume/pressure receptors and osmoreceptors interact in regulating the lamprey RAS. These results indicate an important role for volume/pressor receptors, as in teleosts, but with an additional osmoreceptor mechanism, such that circulatory [angiotensin] is determined by interaction of volume/pressure and osmoreceptors and their relative sensitivities. The volume/pressure sensitivity is in keeping with the recent evidence of a vasoconstrictor action of homologous lamprey angiotensin and provides evidence that the fundamental role of the RAS in maintaining volume and pressure is an ancient function conserved over 500 million years of vertebrate evolution.

  4. Third-generation biosensor for lactose based on newly discovered cellobiose dehydrogenase.

    PubMed

    Stoica, Leonard; Ludwig, Roland; Haltrich, Dietmar; Gorton, Lo

    2006-01-15

    The present paper describes the principle and characteristics of a biosensor for lactose based on a third-generation design involving cellobiose dehydrogenase. As resulted from a previous comparative study (submitted manuscript), the novelty of this lactose biosensor is based on highly efficient direct electron transfer between two newly discovered cellobiose dehydrogenases (CDH), from the white rot fungi Trametes villosa and Phanerochaete sordida, and a solid spectrographic graphite electrode. CDH was immobilized on the electrode surface (0.073 cm2) by simple physical adsorption, and the CDH-modified electrode was next inserted into a wall-jet amperometric cell connected on-line to a flow injection setup (0.5 mL x min(-1)). The P. sordida CDH-based lactose biosensor, proved to be the better one, has a detection limit for lactose of 1 microM, a sensitivity of 1100 microA x mM(-1) x cm(-2), a response time of 4 s (the time required to obtain the maximum peak current), and a linear range from 1 to 100 microM lactose (correlation coefficient 0.998). The simplicity of construction and analytical characteristics make this CDH-based lactose biosensor an excellent alternative to previous lactose biosensors reported in the literature or commercially available. The CDH-lactose sensor was used to quantify the content of lactose in pasteurized milk, buttermilk, and low-lactose milk, using the standard addition method. No effects of the samples matrixes were observed. The operational stability of the sensor was tested for 11 h by continuous injection of 100 microM lactose (290 injections). The final signal of the sensor was maintained at 98% of its initial signal, with a low standard deviation of 1.72 (RSD 2.41%).

  5. Genetic diversity and potential function of microbial symbionts associated with newly discovered species of Osedax polychaete worms.

    PubMed

    Goffredi, Shana K; Johnson, Shannon B; Vrijenhoek, Robert C

    2007-04-01

    We investigated the genetic diversity of symbiotic bacteria associated with two newly discovered species of Osedax from Monterey Canyon, CA, at 1,017-m (Osedax Monterey Bay sp. 3 "rosy" [Osedax sp. MB3]) and 381-m (Osedax Monterey Bay sp. 4 "yellow collar") depths. Quantitative PCR and clone libraries of 16S rRNA gene sequences identified differences in the compositions and abundances of bacterial phylotypes associated with the newly discovered host species and permitted comparisons between adult Osedax frankpressi and juveniles that had recently colonized whalebones implanted at 2,891 m. The newly discovered Osedax species hosted Oceanospirillales symbionts that are related to Gammaproteobacteria associated with the previously described O. frankpressi and Osedax rubiplumus (S. K. Goffredi, V. J. Orphan, G. W. Rouse, L. Jahnke, T. Embaye, K. Turk, R. Lee, and R. C. Vrijenhoek, Environ. Microbiol. 7:1369-1378, 2005). In addition, Osedax sp. MB3 hosts a diverse and abundant population of additional bacteria dominated by Epsilonproteobacteria. Ultrastructural analysis of symbiont-bearing root tissues verified the enhanced microbial diversity of Osedax sp. MB3. Root tissues from the newly described host species and O. frankpressi all exhibited collagenolytic enzyme activity, which covaried positively with the abundance of symbiont DNA and negatively with mean adult size of the host species. Members of this unusual genus of bone-eating worms may form variable associations with symbiotic bacteria that allow for the observed differences in colonization and success in whale fall environments throughout the world's oceans.

  6. An updated survey of globular clusters in M 31. II. Newly discovered bright and remote clusters

    NASA Astrophysics Data System (ADS)

    Galleti, S.; Bellazzini, M.; Federici, L.; Buzzoni, A.; Fusi Pecci, F.

    2007-08-01

    Aims:We present the first results of a large spectroscopic survey of candidate globular clusters located in the extreme outskirts of the nearby M 31 galaxy. The survey is aimed at ascertaining the nature of the selected candidates to increase the sample of confirmed M 31 clusters lying more that 2° away from the center of the galaxy. Methods: We obtained low resolution spectra (λ/Δλ ≃ 800-1300) of 48 targets selected from the Extended Source Catalogue of 2MASS, as in Galleti et al. (2005, A&A, 436, 535). The observed candidates have been robustly classified according to their radial velocity and by verifying their extended/point-source nature from ground-based optical images. We have also obtained a spectrum and a radial velocity estimate for the remote M 31 globular discovered by Martin et al. (2006b, MNRAS, 371, 1983). Results: Among the 48 observed candidates clusters we found: 35 background galaxies, 8 foreground Galactic stars, and 5 genuine remote globular clusters. One of them has been already identified independently by Mackey et al. (2007, ApJ, 655, L85), their GC1; the other four are completely new discoveries: B516, B517, B518, B519. The newly discovered clusters lie at projected distance 40 kpc ≲ R_p≲ 100 kpc from the center of M 31, and have absolute integrated magnitude -9.5 ≲ MV ≲ -7.5. For all the observed clusters we have measured the strongest Lick indices and we have obtained spectroscopic metallicity estimates. Mackey-GC1, Martin-GC1, B517 and B518 have spectra typical of old and metal poor globular clusters ([Fe/H] ≲ -1.3); B519 appears old but quite metal-rich ([Fe/H]~≃ -0.5); B516 presents very strong Balmer absorption lines: if this is indeed a cluster it should have a relatively young age (likely < 2 Gyr). Conclusions: The present analysis nearly doubles the number of M 31 globulars at R_p≥ 40 kpc. At odds with the Milky Way, M 31 appears to have a significant population of very bright globular clusters in its extreme

  7. NEWLY DISCOVERED PLANETS ORBITING HD 5319, HD 11506, HD 75784 AND HD 10442 FROM THE N2K CONSORTIUM

    SciTech Connect

    Giguere, Matthew J.; Fischer, Debra A.; Brewer, John M.; Payne, Matthew J.; Johnson, John Asher; Howard, Andrew W.; Isaacson, Howard T.

    2015-01-20

    Initially designed to discover short-period planets, the N2K campaign has since evolved to discover new worlds at large separations from their host stars. Detecting such worlds will help determine the giant planet occurrence at semi-major axes beyond the ice line, where gas giants are thought to mostly form. Here we report four newly discovered gas giant planets (with minimum masses ranging from 0.4 to 2.1 M {sub Jup}) orbiting stars monitored as part of the Next 2000 target stars (N2K) Doppler Survey program. Two of these planets orbit stars already known to host planets: HD 5319 and HD 11506. The remaining discoveries reside in previously unknown planetary systems: HD 10442 and HD 75784. The refined orbital period of the inner planet orbiting HD 5319 is 641 days. The newly discovered outer planet orbits in 886 days. The large masses combined with the proximity to a 4:3 mean motion resonance make this system a challenge to explain with current formation and migration theories. HD 11506 has one confirmed planet, and here we confirm a second. The outer planet has an orbital period of 1627.5 days, and the newly discovered inner planet orbits in 223.6 days. A planet has also been discovered orbiting HD 75784 with an orbital period of 341.7 days. There is evidence for a longer period signal; however, several more years of observations are needed to put tight constraints on the Keplerian parameters for the outer planet. Lastly, an additional planet has been detected orbiting HD 10442 with a period of 1043 days.

  8. Genetic Diversity and Potential Function of Microbial Symbionts Associated with Newly Discovered Species of Osedax Polychaete Worms▿

    PubMed Central

    Goffredi, Shana K.; Johnson, Shannon B.; Vrijenhoek, Robert C.

    2007-01-01

    We investigated the genetic diversity of symbiotic bacteria associated with two newly discovered species of Osedax from Monterey Canyon, CA, at 1,017-m (Osedax Monterey Bay sp. 3 “rosy” [Osedax sp. MB3]) and 381-m (Osedax Monterey Bay sp. 4 “yellow collar”) depths. Quantitative PCR and clone libraries of 16S rRNA gene sequences identified differences in the compositions and abundances of bacterial phylotypes associated with the newly discovered host species and permitted comparisons between adult Osedax frankpressi and juveniles that had recently colonized whalebones implanted at 2,891 m. The newly discovered Osedax species hosted Oceanospirillales symbionts that are related to Gammaproteobacteria associated with the previously described O. frankpressi and Osedax rubiplumus (S. K. Goffredi, V. J. Orphan, G. W. Rouse, L. Jahnke, T. Embaye, K. Turk, R. Lee, and R. C. Vrijenhoek, Environ. Microbiol. 7:1369-1378, 2005). In addition, Osedax sp. MB3 hosts a diverse and abundant population of additional bacteria dominated by Epsilonproteobacteria. Ultrastructural analysis of symbiont-bearing root tissues verified the enhanced microbial diversity of Osedax sp. MB3. Root tissues from the newly described host species and O. frankpressi all exhibited collagenolytic enzyme activity, which covaried positively with the abundance of symbiont DNA and negatively with mean adult size of the host species. Members of this unusual genus of bone-eating worms may form variable associations with symbiotic bacteria that allow for the observed differences in colonization and success in whale fall environments throughout the world's oceans. PMID:17277220

  9. Selective flower abortion maintains moth cooperation in a newly discovered pollination mutualism.

    PubMed

    Goto, Ryutaro; Okamoto, Tomoko; Kiers, E Toby; Kawakita, Atsushi; Kato, Makoto

    2010-03-01

    The evolutionary stability of mutualisms is enhanced when partners possess mechanisms to prevent overexploitation by one another. In obligate pollination-seed consumption mutualisms, selective abortion of flowers containing excessive eggs represents one such mechanism, but empirical tests have long been limited to the yucca-yucca moth mutualism. We present evidence for selective abortion in the recently discovered mutualism between Glochidion trees and Epicephala moths. In Glochidion acuminatum, proportion of aborted flowers progressively increased both with higher egg load and increased ovule damage. Selective abortion resulted in a 16% seed production increase compared with expectations under random abortion, and moths suffered fitness losses as high as 62% when ovipositing into pre-infested flowers. Moth eggs were laid singly more often than expected under random oviposition, thus avoiding potential disadvantages from multiple infestations. As new pollination mutualisms are being discovered, selective abortion mechanisms may prove to be more widespread than previously thought.

  10. Analysis of Metabolic Pathways and Fluxes in a Newly Discovered Thermophilic and Ethanol-Tolerant Geobacillus Strain

    SciTech Connect

    Tang, Yinjie J.; Sapra, Rajat; Joyner, Dominique; Hazen, Terry C.; Myers, Samuel; Reichmuth, David; Blanch, Harvey; Keasling, Jay D.

    2009-01-20

    A recently discovered thermophilic bacterium, Geobacillus thermoglucosidasius M10EXG, ferments a range of C5 (e.g., xylose) and C6 sugars (e.g., glucose) and istolerant to high ethanol concentrations (10percent, v/v). We have investigated the central metabolism of this bacterium using both in vitro enzyme assays and 13C-based flux analysis to provide insights into the physiological properties of this extremophile and explore its metabolism for bio-ethanol or other bioprocess applications. Our findings show that glucose metabolism in G. thermoglucosidasius M10EXG proceeds via glycolysis, the pentose phosphate pathway, and the TCA cycle; the Entner?Doudoroff pathway and transhydrogenase activity were not detected. Anaplerotic reactions (including the glyoxylate shunt, pyruvate carboxylase, and phosphoenolpyruvate carboxykinase) were active, but fluxes through those pathways could not be accuratelydetermined using amino acid labeling. When growth conditions were switched from aerobic to micro-aerobic conditions, fluxes (based on a normalized glucose uptake rate of 100 units (g DCW)-1 h-1) through the TCA cycle and oxidative pentose phosphate pathway were reduced from 64+-3 to 25+-2 and from 30+-2 to 19+-2, respectively. The carbon flux under micro-aerobic growth was directed formate. Under fully anerobic conditions, G. thermoglucosidasius M10EXG used a mixed acid fermentation process and exhibited a maximum ethanol yield of 0.38+-0.07 mol mol-1 glucose. In silico flux balance modeling demonstrates that lactate and acetate production from G. thermoglucosidasius M10EXG reduces the maximum ethanol yieldby approximately threefold, thus indicating that both pathways should be modified to maximize ethanol production.

  11. Dynamical modeling validation of parent bodies associated with newly discovered CMN meteor showers

    NASA Astrophysics Data System (ADS)

    Šegon, Damir; Vaubaillon, Jérémie; Gural, Peter S.; Vida, Denis; Andreić, Željko; Korlević, Korado; Skokić, Ivica

    2017-01-01

    Context. Results from previous searches for new meteor showers in the combined Croatian Meteor Network and SonotaCo meteor databases suggested possible parent bodies for several newly identified showers. Aims: We aim to perform an analysis to validate the connection between the identified showers and candidate parent bodies. Methods: Simulated particles were ejected from candidate parent bodies, a dynamical modeling was performed and the results were compared to the real meteor shower observations. Results: From the 13 analysed cases, three were found to be connected with comets, four with asteroids which are possibly dormant comets, four were inconclusive or negative, and two need more observational data before any conclusions can be drawn.

  12. Observations of candidate oscillating eclipsing binaries and two newly discovered pulsating variables

    NASA Astrophysics Data System (ADS)

    Liakos, A.; Niarchos, P.

    2009-03-01

    CCD observations of 24 eclipsing binary systems with spectral types ranging between A0-F0, candidate for containing pulsating components, were obtained. Appropriate exposure times in one or more photometric filters were used so that short-periodic pulsations could be detected. Their light curves were analyzed using the Period04 software in order to search for pulsational behaviour. Two new variable stars, namely GSC 2673-1583 and GSC 3641-0359, were discov- ered as by-product during the observations of eclipsing variables. The Fourier analysis of the observations of each star, the dominant pulsation frequencies and the derived frequency spectra are also presented.

  13. Newly discovered sediment rock-hosted disseminated gold deposits in the People's Republic of China

    USGS Publications Warehouse

    Cunningham, Charles G.; Ashley, Roger P.; Chou, I. -Ming; Huang, Zushu; Chaoyuan, Wan; Li, Wenkang

    1988-01-01

    Five deposits discovered in Guizhou Province, Yata, Getang, Sanchahe, Ceyang, and Banqi are described for the first time in Western literature. The deposits have geologic features and geochemical signatures that are remarkably similar to those of sedimentary rock-hosted precious metal deposits in the United States. The sizes of the deposits are as yet undetermined, but they each contain significant reserves at average grades of 4 to 5 g of gold per metric ton. Exploration and drilling are in progress at all of the deposits, and other areas where the geologic setting and geochemical anomalies are similar are being tested.

  14. Bow shocks in a newly discovered maser source in IRAS 20231+3440

    NASA Astrophysics Data System (ADS)

    Ogbodo, C. S.; Burns, R. A.; Handa, T.; Omodaka, T.; Nakagawa, A.; Nagayama, T.; Honma, M.; Chibueze, J. O.; Ubachukwu, A. A.; Eze, R. N. C.

    2017-08-01

    From measuring the annual parallax of water masers over 1.5 yr with VLBI Exploration of Radio Astrometry, we present the trigonometric parallax and corresponding distance of another newly identified water maser source in the region of IRAS 20231+3440 as π = 0.611 ± 0.022 mas and D = 1.64 ± 0.06 kpc, respectively. We measured the absolute proper motions of all the newly detected maser spots (30 spots) and presented two pictures describing the possible spatial distribution of the water maser as the morphology marks out an arc of masers whose average proper motion velocity in the jet direction was 14.26 km s-1. As revealed by the ALLWISE composite image and by applying the colour-colour method of young stellar objects (YSO) identification and classification on photometric archived data, we identified the driving source of the north maser group to be a class I, young stellar object. To further probe the nature of the progenitor, we used the momentum rate maximum value (1.2 × 10-4 M⊙ yr-1 km s-1) of the outflow to satisfy that the progenitor under investigation is a low-mass young stellar object concurrently forming alongside an intermediate-mass YSO ˜60 000 au (˜37 arcsec) away from it.

  15. Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products.

    PubMed

    Blodgett, Joshua A V; Zhang, Jun Kai; Yu, Xiaomin; Metcalf, William W

    2016-01-01

    Natural products containing phosphonic or phosphinic acid functionalities often display potent biological activities with applications in medicine and agriculture. The herbicide phosphinothricin-tripeptide (PTT) was the first phosphinate natural product discovered, yet despite numerous studies, questions remain surrounding key transformations required for its biosynthesis. In particular, the enzymology required to convert phosphonoformate to carboxyphosphonoenolpyruvate and the mechanisms underlying phosphorus methylation remain poorly understood. In addition, the model for non-ribosomal peptide synthetase assembly of the intact tripeptide product has undergone numerous revisions that have yet to be experimentally tested. To further investigate the biosynthesis of this unusual natural product, we completely sequenced the PTT biosynthetic locus from Streptomyces hygroscopicus and compared it with the orthologous cluster from Streptomyces viridochromogenes. We also sequenced and analyzed the closely related phosalacine (PAL) biosynthetic locus from Kitasatospora phosalacinea. Using data drawn from the comparative analysis of the PTT and PAL pathways, we also evaluate three related recently discovered phosphonate biosynthetic loci from Streptomyces sviceus, Streptomyces sp. WM6386 and Frankia alni. Our observations address long-standing biosynthetic questions related to PTT and PAL production and suggest that additional members of this pharmacologically important class await discovery.

  16. Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products

    PubMed Central

    Blodgett, Joshua A. V; Zhang, Jun Kai; Yu, Xiaomin; Metcalf, William W.

    2015-01-01

    Natural products containing phosphonic or phosphinic acid functionalities often display potent biological activities with applications in medicine and agriculture. The herbicide phosphinothricin-tripeptide (PTT) was the first phosphinate natural product discovered, yet despite numerous studies, questions remain surrounding key transformations required for its biosynthesis. In particular, the enzymology required to convert phosphonoformate to carboxyphosphonoenolpyruvate and the mechanisms underlying phosphorus-methylation remain poorly understood. In addition, the model for NRPS assembly of the intact tripeptide product has undergone numerous revisions that have yet to be experimentally tested. To further investigate the biosynthesis of this unusual natural product, we completely sequenced the PTT biosynthetic locus from Streptomyces hygroscopicus and compared it to the orthologous cluster from Streptomyces viridochromogenes. We also sequenced and analysed the closely related phosalacine (PAL) biosynthetic locus from Kitasatospora phosalacinea. Using data drawn from the comparative analysis of the PTT and PAL pathways, we also evaluate three related recently discovered phosphonate biosynthetic loci from Streptomyces sviceus, Streptomyces sp. WM6386 and Frankia alni. Our observations address long-standing biosynthetic questions related to PTT and PAL production and suggest that additional members of this pharmacologically important class await discovery. PMID:26328935

  17. Application potential of a newly isolated indigenous aerobic denitrifier for nitrate and ammonium removal of eutrophic lake water.

    PubMed

    Guo, Liyun; Chen, Qiankun; Fang, Fei; Hu, Zhixin; Wu, Jun; Miao, Aijun; Xiao, Lin; Chen, Xiaofeng; Yang, Liuyan

    2013-08-01

    The aim of this work was to evaluate the utilization potential of a newly isolated indigenous aerobic denitrifier, Pseudomonas stutzeri strain T1, for nitrogen removal from the eutrophic Lake Taihu in China. The strain was capable of conducting heterotrophic nitrification-aerobic denitrification and had both excellent nitrate and ammonium removal without nitrite build-up. The characteristics of P. stutzeri strain T1 were studied under different cultural conditions. Furthermore, under the optimized cultivation conditions, strain T1 was added into the water samples from Lake Taihu, the ammonium and nitrate removal rates of the strain reached to 60% and 75%, respectively. Via adding this strain, the water qualities of the sample ameliorated from Grade V to Grade II. Thus, the strain T1 should be an useful biological tool to remediate eutrophic lakes and do not meet acclimation problems.

  18. G306.3-0.9: A Newly Discovered Young Galactic Supernova Remnant

    NASA Technical Reports Server (NTRS)

    Reynolds, Mark T.; Loi, Syheh T.; Murphy, Tara; Miller, Jon M.; Maitra, Dipankar; Gueltekin, Kayhan; Gehrels, Neil; Kennea, Jamie A.; Siegel, Michael H.; Gelbord, Jonathan; hide

    2013-01-01

    We present X-ray and radio observations of the new Galactic supernova remnant (SNR) G306.3-0.9, recently discovered by Swift. Chandra imaging reveals a complex morphology, dominated by a bright shock. The X-ray spectrum is broadly consistent with a young SNR in the Sedov phase, implying an age of 2500 yr for a distance of 8 kpc, plausibly identifying this as one of the 20 youngest Galactic SNRs. Australia Telescope Compact Array imaging reveals a prominent ridge of radio emission that correlates with the X-ray emission. We find a flux density of 160 mJy at 1 GHz, which is the lowest radio flux recorded for a Galactic SNR to date. The remnant is also detected at 24µm, indicating the presence of irradiated warm dust. The data reveal no compelling evidence for the presence of a compact stellar remnant.

  19. G306.3-0.9: A NEWLY DISCOVERED YOUNG GALACTIC SUPERNOVA REMNANT

    SciTech Connect

    Reynolds, Mark T.; Miller, Jon M.; Maitra, Dipankar; Gueltekin, Kayhan; Reis, Rubens C.; Loi, Shyeh T.; Murphy, Tara; Moss, Vanessa; Reeves, Sarah; Robbins, William J.; Gaensler, B. M.; Gehrels, Neil; Petre, Robert; Kennea, Jamie A.; Siegel, Michael H.; Gelbord, Jonathan; Kuin, Paul

    2013-04-01

    We present X-ray and radio observations of the new Galactic supernova remnant (SNR) G306.3-0.9, recently discovered by Swift. Chandra imaging reveals a complex morphology, dominated by a bright shock. The X-ray spectrum is broadly consistent with a young SNR in the Sedov phase, implying an age of 2500 yr for a distance of 8 kpc, plausibly identifying this as one of the 20 youngest Galactic SNRs. Australia Telescope Compact Array imaging reveals a prominent ridge of radio emission that correlates with the X-ray emission. We find a flux density of {approx}160 mJy at 1 GHz, which is the lowest radio flux recorded for a Galactic SNR to date. The remnant is also detected at 24 {mu}m, indicating the presence of irradiated warm dust. The data reveal no compelling evidence for the presence of a compact stellar remnant.

  20. Anatomy and histology of the newly discovered adipose sac structure within the labia majora: international original research.

    PubMed

    Ostrzenski, Adam; Krajewski, Pawel; Davis, Kern

    2016-09-01

    To determine whether there is any new anatomical structure present within the labia majora. A case serial study was executed on eleven consecutive fresh human female cadavers. Stratum-by-stratum dissections of the labia majora were performed. Twenty-two anatomic dissections of labia majora were completed. Eosin and Hematoxylin agents were used to stain newly discovered adipose sac's tissues of the labia majora and the cylinder-like structures, which cover condensed adipose tissues. The histology of these two structures was compared. All dissected labia majora demonstrated the presence of the anatomic existence of the adipose sac structure. Just under the dermis of the labia majora, the adipose sac was located, which was filled with lobules containing condensed fatty tissues in the form of cylinders. The histological investigation established that the well-organized fibro-connective-adipose tissues represented the adipose sac. The absence of descriptions of the adipose sac within the labia majora in traditional anatomic and gynecologic textbooks was noted. In this study group, the newly discovered adipose sac is consistently present within the anatomical structure of the labia majora. The well-organized fibro-connective-adipose tissue represents microscopic characteristic features of the adipose sac.

  1. Genomic Analyses Reveal Demographic History and Temperate Adaptation of the Newly Discovered Honey Bee Subspecies Apis mellifera sinisxinyuan n. ssp.

    PubMed

    Chen, Chao; Liu, Zhiguang; Pan, Qi; Chen, Xiao; Wang, Huihua; Guo, Haikun; Liu, Shidong; Lu, Hongfeng; Tian, Shilin; Li, Ruiqiang; Shi, Wei

    2016-05-01

    Studying the genetic signatures of climate-driven selection can produce insights into local adaptation and the potential impacts of climate change on populations. The honey bee (Apis mellifera) is an interesting species to study local adaptation because it originated in tropical/subtropical climatic regions and subsequently spread into temperate regions. However, little is known about the genetic basis of its adaptation to temperate climates. Here, we resequenced the whole genomes of ten individual bees from a newly discovered population in temperate China and downloaded resequenced data from 35 individuals from other populations. We found that the new population is an undescribed subspecies in the M-lineage of A. mellifera (Apis mellifera sinisxinyuan). Analyses of population history show that long-term global temperature has strongly influenced the demographic history of A. m. sinisxinyuan and its divergence from other subspecies. Further analyses comparing temperate and tropical populations identified several candidate genes related to fat body and the Hippo signaling pathway that are potentially involved in adaptation to temperate climates. Our results provide insights into the demographic history of the newly discovered A. m. sinisxinyuan, as well as the genetic basis of adaptation of A. mellifera to temperate climates at the genomic level. These findings will facilitate the selective breeding of A. mellifera to improve the survival of overwintering colonies. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  2. Genomic Analyses Reveal Demographic History and Temperate Adaptation of the Newly Discovered Honey Bee Subspecies Apis mellifera sinisxinyuan n. ssp

    PubMed Central

    Chen, Chao; Liu, Zhiguang; Pan, Qi; Chen, Xiao; Wang, Huihua; Guo, Haikun; Liu, Shidong; Lu, Hongfeng; Tian, Shilin; Li, Ruiqiang; Shi, Wei

    2016-01-01

    Studying the genetic signatures of climate-driven selection can produce insights into local adaptation and the potential impacts of climate change on populations. The honey bee (Apis mellifera) is an interesting species to study local adaptation because it originated in tropical/subtropical climatic regions and subsequently spread into temperate regions. However, little is known about the genetic basis of its adaptation to temperate climates. Here, we resequenced the whole genomes of ten individual bees from a newly discovered population in temperate China and downloaded resequenced data from 35 individuals from other populations. We found that the new population is an undescribed subspecies in the M-lineage of A. mellifera (Apis mellifera sinisxinyuan). Analyses of population history show that long-term global temperature has strongly influenced the demographic history of A. m. sinisxinyuan and its divergence from other subspecies. Further analyses comparing temperate and tropical populations identified several candidate genes related to fat body and the Hippo signaling pathway that are potentially involved in adaptation to temperate climates. Our results provide insights into the demographic history of the newly discovered A. m. sinisxinyuan, as well as the genetic basis of adaptation of A. mellifera to temperate climates at the genomic level. These findings will facilitate the selective breeding of A. mellifera to improve the survival of overwintering colonies. PMID:26823447

  3. Necrosis Avidity: A Newly Discovered Feature of Hypericin and its Preclinical Applications in Necrosis Imaging

    PubMed Central

    Jiang, Binghu; Wang, Jichen; Ni, Yicheng; Chen, Feng

    2013-01-01

    Hypericin has been widely studied as a potent photosensitizer for photodynamic therapy in both preclinical and clinical settings. Recently, hypericin has also been discovered to have a specific avidity for necrotic tissue. This affinity is also observed in a series of radiolabeled derivatives of hypericin, including [123I]iodohypericin, [124I]iodohypericin, and [131I]iodohypericin. Hypericin, along with other necrosis-avid contrast agents, has been investigated for use in noninvasively targeting necrotic tissues in numerous disorders. Potential clinical applications of hypericin include the identification of acute myocardial infarction, evaluation of tissue viability, assessment of therapeutic responses to treatments, and interventional procedures for solid tumors. The mechanisms of necrosis avidity in hypericin remain to be fully elucidated, although several hypotheses have been suggested. In particular, it has been proposed that the necrosis avidity of hypericin is compound specific; for instance, cholesterol, phosphatidylserine, or phosphatidylethanolamine components in the phospholipid bilayer of cellular membranes may be the major targets for its observed selectivity. Further investigations are needed to identify the specific binding moiety that is responsible for the necrosis avidity of hypericin. PMID:24052807

  4. ASCA and Bepposax Observations of the Newly Discovered SNR RX J0852-4622

    NASA Technical Reports Server (NTRS)

    Slane, Patrick; Oliversen, Ronald J. (Technical Monitor)

    2003-01-01

    This grant supports an investigation of the supernova remnant RX J0852-4622 (G266.1-1.2), a large-diameter, nearby SNR for which the X-ray emission is dominated by nonthermal processes. As only the third such SNR discovered, for which there is direct evidence of cosmic-ray acceleration dominating the SNR dynamics, this is an exceptionally important object. Our progress on this study to date has been good. We have published the results of a spectral mapping of the XNR as well as the identification of a compact X-ray source which may be the associated neutron star. Our final work involves modeling of the emission using limits from the radio flux in order to estimate the inverse-Compton flux that might be observable in the TeV gamma-ray regime. We have just completed similar modeling of the emission from G347.3-0.5 (Lazendic et al. - submitted to ApJ), and the results have drawn considerable interest in the gamma-ray community (Slane 2002; astro-ph/0212353). Extensive observations of G266.1--1.2 with the CANGAROO TeV gamma-ray telescope have been carried out, and our modeling of the broad-band emission characteristic are of importance for such studies.

  5. Psychotherapy and moralising rhetoric in Galen's newly discovered Avoiding Distress (Peri Alypias).

    PubMed

    Xenophontos, Sophia

    2014-10-01

    In this article, I examine Galen's credentials as an ethical philosopher on the basis of his recently discovered essay Avoiding Distress (Peri alypias). As compensation for the scholarly neglect from which Galen's ethics suffers, I argue that his moral agenda is an essential part of his philosophical discourse, one that situates him firmly within the tradition of practical ethics of the Roman period. Galen's engagement with Stoic psychotherapy and the Platonic-Aristotelian educational model affirms his ethical authority; on the other hand, his distinctive moralising features such as the autobiographical perspective of his narrative and the intimacy between author and addressee render his Avoiding Distress exceptional among other essays, Greek or Latin, treating anxiety. Additionally, I show that Galen's self-projection as a therapist of the emotions corresponds to his role as a practising physician, especially as regards the construction of authority, the efficacy of his therapy and the importance of personal experience as attested in his medical accounts. Finally, the diligence with which Galen retextures his moral advice in his On the Affections and Errors of the Soul - a work of different nature and intent in relation to Avoiding Distress - is a testimony to the dynamics of his ethics and more widely to his philosophical medicine. The philosopher's lecture room is a 'hospital': you ought not to walk out of it in a state of pleasure, but in pain; for you are not in good condition when you arrive. Epictetus, Discourses 3.23.30.

  6. Modeling transiting circumstellar disks: characterizing the newly discovered eclipsing disk system OGLE LMC-ECL-11893

    SciTech Connect

    Scott, Erin L.; Mamajek, Eric E.; Pecaut, Mark J.; Quillen, Alice C.; Moolekamp, Fred; Bell, Cameron P. M.

    2014-12-10

    We investigate the nature of the unusual eclipsing star OGLE LMC-ECL-11893 (OGLE J05172127-6900558) in the Large Magellanic Cloud recently reported by Dong et al. The eclipse period for this star is 468 days, and the eclipses exhibit a minimum of ∼1.4 mag, preceded by a plateau of ∼0.8 mag. Spectra and optical/IR photometry are consistent with the eclipsed star being a lightly reddened B9III star of inferred age ∼150 Myr and mass ∼4 M {sub ☉}. The disk appears to have an outer radius of ∼0.2 AU with predicted temperatures of ∼1100-1400 K. We model the eclipses as being due to either a transiting geometrically thin dust disk or gaseous accretion disk around a secondary object; the debris disk produces a better fit. We speculate on the origin of such a dense circumstellar dust disk structure orbiting a relatively old low-mass companion, and on the similarities of this system to the previously discovered EE Cep.

  7. Physical parameters and orbital period variation of a newly discovered cataclysmic variable GSC 4560-02157

    NASA Astrophysics Data System (ADS)

    Han, Zhong-Tao; Qian, Sheng-Bang; Voloshina, Irina; Metlov, Vladimir G.; Zhu, Li-Ying; Li, Lin-Jia

    2016-10-01

    GSC 4560-02157 is a new eclipsing cataclysmic variable with an orbital period of 0.265359 days. By using the published V - and R - band data together with our observations, we discovered that the O - C curve of GSC 4560-02157 may show a cyclic variation with a period of 3.51 years and an amplitude of 1.40 min. If this variation is caused by a light travel-time effect via the existence of a third body, then its mass can be derived as M 3 sin i' ≈ 91.08 M Jup, and it should be a low-mass star. In addition, several physical parameters were measured. The color of the secondary star was determined to be V - R = 0.77(±0.03) which corresponds to a spectral type of K2-3. The secondary star's mass was estimated as M 2 = 0.73(±0.02) M ⊙ by combing the derived V - R value around phase 0 with the assumption that it obeys the mass-luminosity relation for main sequence stars. This mass is consistent with the mass—period relation for CV donor stars. For the white dwarf, the eclipse durations and contacts of the white dwarf yield an upper limit on the white dwarf's radius corresponding to a lower limit on mass of M 1 ≈ 0.501 M ⊙. The overestimated radius and previously published spectral data indicate that the boundary layer may have a very high temperature.

  8. HERSCHEL OBSERVATIONS OF A NEWLY DISCOVERED UX Ori STAR IN THE LARGE MAGELLANIC CLOUD

    SciTech Connect

    Clayton, Geoffrey C.; Sargent, B.; Boyer, M. L.; Meixner, M.; Roman-Duval, J.; Sewilo, M. E-mail: duval@stsci.ed E-mail: meixner@stsci.ed E-mail: sargent@stsci.ed

    2010-10-20

    The LMC star, SSTISAGE1C J050756.44-703453.9, was first noticed during a survey of EROS-2 light curves for stars with large irregular brightness variations typical of the R Coronae Borealis (RCB) class. However, the visible spectrum showing emission lines including the Balmer and Paschen series as well as many Fe II lines is emphatically not that of an RCB star. This star has all of the characteristics of a typical UX Ori star. It has a spectral type of approximately A2 and has excited an H II region in its vicinity. However, if it is an LMC member, then it is very luminous for a Herbig Ae/Be star. It shows irregular drops in brightness of up to 2 mag, and displays the reddening and 'blueing' typical of this class of stars. Its spectrum, showing a combination of emission and absorption lines, is typical of a UX Ori star that is in a decline caused by obscuration from the circumstellar dust. SSTISAGE1C J050756.44-703453.9 has a strong IR excess and significant emission is present out to 500 {mu}m. Monte Carlo radiative transfer modeling of the spectral energy distribution requires that SSTISAGE1C J050756.44-703453.9 have both a dusty disk as well as a large extended diffuse envelope to fit both the mid- and far-IR dust emission. This star is a new member of the UX Ori subclass of the Herbig Ae/Be stars and only the second such star to be discovered in the LMC.

  9. Walther Flemming on histology in medicine 1878: a newly discovered letter to his father.

    PubMed

    Hardy, Paul A; Zacharias, Helmut

    2009-04-01

    Histology is a child of the 19th century, and its status in medicine was long in doubt. Was "microscopic anatomy" to be viewed as a refinement of the traditional discipline or as a technically complex subject of doubtful practical value? This was one of the questions that faced the commission charged with reforming examinations in German medical schools in 1878. One of its members, Carl Friedrich Flemming [1799-1880], was able to refer this matter to an acknowledged expert, his son Walther Flemming, who was Professor of Anatomy and Histology at the University of Kiel. Walther's views are contained in a letter that was recently discovered among Carl Friedrich's papers held in the State Library of Mecklenburg-Vorpommern in Schwerin. To the best of our knowledge, this letter is the only surviving piece of personal correspondence from the hand of Walther Flemming, one of the most distinguished biologists of his time. The original text, together with an annotated English translation, is published here for the first time. The letter throws new light on Flemming's attitudes to medical education, and also illuminates his relationship with his father, himself a figure of considerable stature in psychiatric medicine in 19th-century Germany. The younger Flemming [1843-1905], an acknowledged master of microscopy, made his most distinguished contributions to the field we now call cell biology. In addition to the terms chromatin and mitosis, we owe to him the first comprehensive account of the latter, as well as the fundamental insight that meiosis involves two successive divisions.

  10. The Nature of Newly Discovered Wolf-Rayet Stars in the LMC

    NASA Astrophysics Data System (ADS)

    Massey, Philip

    2014-10-01

    We have recently discovered five Wolf-Rayet (WR) stars in the LMC which might be naively classified as "WN3+O3 V." However, such a pairing is unlikely for a number of reasons: (a) O3 V stars are very rare, as they are the hottest and most luminous of the dwarfs; (b) the absolute visual magnitudes of our stars are quite faint (Mv=-3) compared to even an O3 V star by itself (Mv=-5.5); (c) these stars do not exhibit radial velocity variations, although our data on this are admittedly limited; and (d) such a pairing would be hard to understand from a stellar evolution point of view, since a massive star will evolve out of the O3 V phase in about a million years, while it takes several million years to form a WN star. We are forced to conclude that we have discoverd a new class of WRs. We have excellent optical spectra with Magellan, and our modeling of these data suggest a very high effective temperature (70,000 K), strongly enhanced nitrogen, and a very low mass-loss rate. However, these physical parameters are poorly constrained by the optical data alone, and we now seek UV spectra that will contain lines that will better determine the temperatures, and the important resonance lines that provide crucial diagnostics of the stellar winds. The results of this modeling will allow us to understand the nature of these objects, and where they fit in the evolution of massive stars. If they are the products of single star evolution, they indicate we have some fundamental misconceptions. If they are the products of binary evolution, how do we explain the absence of any companions? We can only address these questions by having reliable stellar parameters and abundances.

  11. Newly discovered globular clusters in NGC 147 and NGC 185 from PAndAS

    NASA Astrophysics Data System (ADS)

    Veljanoski, J.; Ferguson, A. M. N.; Huxor, A. P.; Mackey, A. D.; Fishlock, C. K.; Irwin, M. J.; Tanvir, N.; Chapman, S. C.; Ibata, R. A.; Lewis, G. F.; McConnachie, A.

    2013-11-01

    Using data from the Pan-Andromeda Archaeological Survey (PAndAS), we have discovered four new globular clusters (GCs) associated with the M31 dwarf elliptical (dE) satellites NGC 147 and NGC 185. Three of these are associated with NGC 147 and one with NGC 185. All lie beyond the main optical boundaries of the galaxies and are the most remote clusters yet known in these systems. Radial velocities derived from low-resolution spectra are used to argue that the GCs are bound to the dwarfs and are not part of the M31 halo population. Combining PAndAS with United Kingdom Infrared Telescope (UKIRT)/WFCAM (Wide-Field Camera) data, we present the first homogeneous optical and near-IR photometry for the entire GC systems of these dEs. Colour-colour plots and published colour-metallicity relations are employed to constrain GC ages and metallicities. It is demonstrated that the clusters are in general metal poor ([Fe/H] < -1.25 dex), while the ages are more difficult to constrain. The mean (V - I)0 colours of the two GC systems are very similar to those of the GC systems of dEs in the Virgo and Fornax clusters, as well as the extended halo GC population in M31. The new clusters bring the GC-specific frequency (SN) to ˜9 in NGC 147 and ˜5 in NGC 185, consistent with values found for dEs of similar luminosity residing in a range of environments.

  12. Mantle peridotite in newly discovered far-inland subduction complex, southwest Arizona: Initial report

    USGS Publications Warehouse

    Haxel, Gordon B.; Jacobson, Carl E.; Wittke, James H.

    2015-01-01

    The latest Cretaceous to early Palaeogene Orocopia Schist and related units are generally considered a low-angle subduction complex that underlies much of southern California and Arizona. A recently discovered exposure of Orocopia Schist at Cemetery Ridge west of Phoenix, Arizona, lies exceptionally far inland from the continental margin. Unexpectedly, this body of Orocopia Schist contains numerous blocks, as large as ~300 m, of variably serpentinized mantle peridotite. These are unique; elsewhere in the Orocopia and related schists, peridotite is rare and completely serpentinized. Peridotite and metaperidotite at Cemetery Ridge are of three principal types: (1) serpentinite and tremolite serpentinite, derived from dunite; (2) partially serpentinized harzburgite and olivine orthopyroxenite (collectively, harzburgite); and (3) granoblastic or schistose metasomatic rocks, derived from serpentinite, made largely of actinolite, calcic plagioclase, hercynite, and chlorite. In the serpentinite, paucity of relict olivine, relatively abundant magnetite (5%), and elevated Fe3+/Fe indicate advanced serpentinization. Harzburgite contains abundant orthopyroxene, only slightly serpentinized, and minor to moderate (1–15%) relict olivine. Mantle tectonite fabric is locally preserved. Several petrographic and geochemical characteristics of the peridotite at Cemetery Ridge are ambiguously similar to either abyssal or mantle-wedge (suprasubduction) peridotites and serpentinites. Least ambiguous are orthopyroxene compositions. Orthopyroxene is distinctively depleted in Al2O3, Cr2O3, and CaO, indicating mantle-wedge affinities. Initial interpretation of field and petrologic data suggests that the peridotite blocks in the Orocopia Schist subduction complex at Cemetery Ridge may be derived from the leading corner or edge of a mantle wedge, presumably in (pre-San Andreas fault) southwest California. However, derivation from a subducting plate is not precluded.

  13. Psychotherapy and Moralising Rhetoric in Galen’s Newly Discovered Avoiding Distress (Peri Alypias)

    PubMed Central

    Xenophontos, Sophia

    2014-01-01

    In this article, I examine Galen’s credentials as an ethical philosopher on the basis of his recently discovered essay Avoiding Distress (Peri alypias). As compensation for the scholarly neglect from which Galen’s ethics suffers, I argue that his moral agenda is an essential part of his philosophical discourse, one that situates him firmly within the tradition of practical ethics of the Roman period. Galen’s engagement with Stoic psychotherapy and the Platonic-Aristotelian educational model affirms his ethical authority; on the other hand, his distinctive moralising features such as the autobiographical perspective of his narrative and the intimacy between author and addressee render his Avoiding Distress exceptional among other essays, Greek or Latin, treating anxiety. Additionally, I show that Galen’s self-projection as a therapist of the emotions corresponds to his role as a practising physician, especially as regards the construction of authority, the efficacy of his therapy and the importance of personal experience as attested in his medical accounts. Finally, the diligence with which Galen retextures his moral advice in his On the Affections and Errors of the Soul – a work of different nature and intent in relation to Avoiding Distress – is a testimony to the dynamics of his ethics and more widely to his philosophical medicine. The philosopher’s lecture room is a ‘hospital’: you ought not to walk out of it in a state of pleasure, but in pain; for you are not in good condition when you arrive. Epictetus, Discourses 3.23.30 PMID:25284896

  14. Isolation and Genetic Characterization of Mangshi Virus: A Newly Discovered Seadornavirus of the Reoviridae Family Found in Yunnan Province, China

    PubMed Central

    Wang, Jinglin; Li, Huachun; He, Yuwen; Zhou, Yang; Meng, Jingxing; Zhu, Wuyang; Chen, Hongyu; Liao, Defang; Man, Yunping

    2015-01-01

    Background Seadornavirus is a genus of viruses in the family Reoviridae, which consists of Banna virus, Kadipiro virus, and Liao ning virus. Banna virus is considered a potential pathogen for zoonotic diseases. Here, we describe a newly discovered Seadornavirus isolated from mosquitos (Culex tritaeniorhynchus) in Yunnan Province, China, which is related to Banna virus, and referred to as Mangshi virus. Methods and Results The Mangshi virus was isolated by cell culture in Aedes albopictus C6/36 cells, in which it replicated and caused cytopathic effects, but not in mammalian BHK-21 or Vero cells. Polyacrylamide gel analysis revealed a genome consisting of 12 segments of double-stranded RNA, with a “6–4–2” pattern in which the migrating bands were different from those of the Banna virus. Complete genome sequencing was performed by full-length amplification of cDNAs. Sequence analysis showed that seven highly conserved nucleotides and three highly conserved nucleotides were present at the ends of the 5′- and 3′-UTRs in each of 12 genome segments. The amino acid identities of Mangshi virus shared with Balaton virus varied from 27.3% (VP11) to 72.3% (VP1) with Banna virus varying from 18.0% (VP11) to 63.9% (VP1). Phylogenetic analysis based on amino acid sequences demonstrated that Mangshi virus is a member of the genus Seadornavirus and is most closely related to, but distinct from, Balaton virus and Banna virus in the genus Seadornavirus of the family Reoviridae. Conclusion Mangshi virus isolated from mosquitoes (C. tritaeniorhynchus) was identified as a newly discovered virus in the genus Seadornavirus and is phylogenetically close to Banna virus, suggesting that there is genetic diversity of seadornaviruses in tropical and subtropical areas of Southeast Asia. PMID:26630378

  15. [The biological characteristics of a mucoid Pseudomonas aeruginosa strain with a newly discovered mutation of mucA gene].

    PubMed

    Ni, Ming; Tian, De-ying; Yu, Bing; Pi, Bin; Zhu, Xu-hui; Zhang, Dong-shen

    2004-10-02

    To compare the mucA gene sequence, biofilm formation, growth rate and antibiotic resistance of a mucoid Pseudomonas aeruginosa strain 'PA17' with those of the nonmucoid strain PAOI. The mucA genes of PA17 and PAOI were amplified and the PCR products were sequenced. Biofilm was established and detected with scanning electron microscope 8 h, 24 h, 3 d and 6 d later. Clones counting method was used to compare the growth curves of PA17 and PAOI. International standard plate dilution method was used to detect the susceptibility of common antibiotics for PA17 and PAOI in vitro. There was a 166-333 deletion mutation in mucA gene of PA17. The biofilm formation rate and growth rate of PA17 were noticeably lower than those of PAOI. The antibiotic resistance profile of PA17 was identical to that of PAOI. A mucoid Pseudomonas aeruginosa with a new type of mutation of mucA gene is discovered. The biologic characteristics of this strain are different from those of the mucoid Pseudomonas aeruginosa strain reported previously, which may be related with the newly discovered mutation of mucA gene.

  16. [Relaxin-3 and relaxin family peptide receptors--from structure to functions of a newly discovered mammalian brain system].

    PubMed

    Kania, Alan; Lewandowski, Marian H; Błasiak, Anna

    2014-01-01

    Relaxin-3, a member of the relaxin peptide family, was discovered in 2001 as a homologue of relaxin--a well-known reproductive hormone. However, it is the brain which turned out to be a major expression site of this newly discovered peptide. Both its molecular structure and expression pattern were shown to be very conserved among vertebrates. Extensive research carried out since the discovery of relaxin-3 contributed to the significant progress in our knowledge regarding this neuropeptide. The endogenous relaxin-3 receptor (RXFP3) was identified and the anatomy of the yet uncharacterized mammalian brain system was described, with nucleus incertus as the main center of relaxin-3 expression. Not only its diffusive projections throughout the whole brain, which reach various brain structures such as the hippocampus, septum, intergeniculate leaflet or amygdala, but also functional studies of the relaxin-3/RXFP3 signaling system, allowed this brain network to be classified as one of the ascending nonspecific brain systems. Thus far, research depicts the connection of relaxin-3 with phenomena such as feeding behavior, spatial memory, sleep/wake cycle or modulation of pituitary gland hormone secretion. Responsiveness of relaxin-3 neurons to stress factors and the strong orexigenic effect exerted by this peptide suggest its participation in modulation of feeding by stress, in particular of the chronic type. The discovery of relaxin-3 opened a new research field which will contribute to our better understanding of the neurobiological basis of feeding disorders.

  17. A newly discovered impact crater in Titan's Senkyo: Cassini VIMS observations and comparison with other impact features

    USGS Publications Warehouse

    Buratti, B.J.; Sotin, Christophe; Lawrence, K.; Brown, R.H.; Le, Mouelic S.; Soderblom, J.M.; Barnes, J.; Clark, R.N.; Baines, K.H.; Nicholson, P.D.

    2012-01-01

    Senkyo is an equatorial plain on Titan filled with dunes and surrounded by hummocky plateaus. During the Titan targeted flyby T61 on August 25, 2009, the Cassini Visual and Infrared Mapping Spectrometer (VIMS) onboard the Cassini spacecraft observed a circular feature, centered at 5.4?? N and 341??W, that superimposes the dune fields and a bright plateau. This circular feature, which has been named Paxsi by the International Astronomical Union, is 120??10 km in diameter (measured from the outer edge of the crater rim) and exhibits a central bright area that can be interpreted as the central peak or pit of an impact crater. Although there are only a handful of certain impact craters on Titan, there are two other craters that are of similar size to this newly discovered feature and that have been studied by VIMS: Sinlap (Le Mou??lic et al, 2008) and Selk (Soderblom et al, 2010). Sinlap is associated with a large downwind, fan-like feature that may have been formed from an impact plume that rapidly expanded and deposited icy particles onto the surface. Although much of the surrounding region is covered with dunes, the plume region is devoid of dunes. The formation process of Selk also appears to have removed (or covered up) dunes from parts of the adjacent dune-filled terrain. The circular feature on Senkyo is quite different: there is no evidence of an ejecta blanket and the crater itself appears to be infilled with dune material. The rim of the crater appears to be eroded by fluvial processes; at one point the rim is breached. The rim is unusually narrow, which may be due to mass wasting on its inside and subsequent infill by dunes. Based on these observations, we interpret this newly discovered feature to be a more eroded crater than both Sinlap and Selk. Paxsi may have formed during a period when Titan was warmer and more ductile than it is currently. ?? 2011 Elsevier Ltd. All rights reserved.

  18. Brain Volume of the Newly-Discovered Species Rhynchocyon udzungwensis (Mammalia: Afrotheria: Macroscelidea): Implications for Encephalization in Sengis

    PubMed Central

    Kaufman, Jason A.; Turner, Gregory H.; Holroyd, Patricia A.; Rovero, Francesco; Grossman, Ari

    2013-01-01

    The Gray-faced Sengi (Rhynchocyon udzungwensis) is a newly-discovered species of sengi (elephant-shrew) and is the largest known extant representative of the order Macroscelidea. The discovery of R. udzungwensis provides an opportunity to investigate the scaling relationship between brain size and body size within Macroscelidea, and to compare this allometry among insectivorous species of Afrotheria and other eutherian insectivores. We performed a spin-echo magnetic resonance imaging (MRI) scan on a preserved adult specimen of R. udzungwensis using a 7-Tesla high-field MR imaging system. The brain was manually segmented and its volume was compiled into a dataset containing previously-published allometric data on 56 other species of insectivore-grade mammals including representatives of Afrotheria, Soricomorpha and Erinaceomorpha. Results of log-linear regression indicate that R. udzungwensis exhibits a brain size that is consistent with the allometric trend described by other members of its order. Inter-specific comparisons indicate that macroscelideans as a group have relatively large brains when compared with similarly-sized terrestrial mammals that also share a similar diet. This high degree of encephalization within sengis remains robust whether sengis are compared with closely-related insectivorous afrotheres, or with more-distantly-related insectivorous laurasiatheres. PMID:23516530

  19. Prediction study of the elastic and thermodynamic properties of the newly discovered tetragonal SrPd 2Ge 2 phase

    NASA Astrophysics Data System (ADS)

    Ghebouli, M. A.; Bouhemadou, A.; Ghebouli, B.; Fatmi, M.; Bin-Omran, S.

    2011-07-01

    Density functional theory pseudo-potential plane-wave calculations are performed in order to predict the structural, elastic and thermodynamic properties of the newly discovered tetragonal intermetallic SrPd 2Ge 2. The computed equilibrium lattice constants and the internal parameter are in good agreement with the experimental findings. The effect of high pressure, up to 40 GPa, on the lattice constants shows that the contraction along the c axis is higher than along the a axis. The single-crystal elastic constants and related properties are calculated using the static finite strain technique. We predicted the bulk modulus, shear modulus, Young's modulus and Poisson's ratio for ideal polycrystalline SrPd 2Ge 2 aggregates, using the Voigt-Reuss-Hill approximations. We estimated the Debye temperature and minimum thermal conductivity of SrPd 2Ge 2 from the average sound velocity. Through the quasi-harmonic Debye model, in which the phononic effects are considered, the temperature and pressure effects on the primitive cell volume, bulk modulus, thermal expansion coefficient, heat capacity and Debye temperature are investigated. This is the first quantitative theoretical prediction of the elastic and thermodynamic properties of the SrPd 2Ge 2 compound, and it still awaits experimental confirmation.

  20. Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells.

    PubMed

    Christodoulou, Andri; Santarella-Mellwig, Rachel; Santama, Niovi; Mattaj, Iain W

    2016-04-15

    The mechanism of endoplasmic reticulum (ER) morphogenesis is incompletely understood. ER tubules are shaped by the reticulons (RTNs) and DP1/Yop1p family members, but the mechanism of ER sheet formation is much less clear. Here, we characterize TMEM170A, a human transmembrane protein, which localizes in ER and nuclear envelope membranes. Silencing or overexpressing TMEM170A in HeLa K cells alters ER shape and morphology. Ultrastructural analysis reveals that downregulation of TMEM170A specifically induces tubular ER formation, whereas overexpression of TMEM170A induces ER sheet formation, indicating that TMEM170A is a newly discovered ER-sheet-promoting protein. Additionally, downregulation of TMEM170A alters nuclear shape and size, decreases the density of nuclear pore complexes (NPCs) in the nuclear envelope and causes either a reduction in inner nuclear membrane (INM) proteins or their relocalization to the ER. TMEM170A interacts with RTN4, a member of the reticulon family; simultaneous co-silencing of TMEM170A and RTN4 rescues ER, NPC and nuclear-envelope-related phenotypes, implying that the two proteins have antagonistic effects on ER membrane organization, and nuclear envelope and NPC formation.

  1. Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells

    PubMed Central

    Christodoulou, Andri; Santarella-Mellwig, Rachel; Santama, Niovi

    2016-01-01

    ABSTRACT The mechanism of endoplasmic reticulum (ER) morphogenesis is incompletely understood. ER tubules are shaped by the reticulons (RTNs) and DP1/Yop1p family members, but the mechanism of ER sheet formation is much less clear. Here, we characterize TMEM170A, a human transmembrane protein, which localizes in ER and nuclear envelope membranes. Silencing or overexpressing TMEM170A in HeLa K cells alters ER shape and morphology. Ultrastructural analysis reveals that downregulation of TMEM170A specifically induces tubular ER formation, whereas overexpression of TMEM170A induces ER sheet formation, indicating that TMEM170A is a newly discovered ER-sheet-promoting protein. Additionally, downregulation of TMEM170A alters nuclear shape and size, decreases the density of nuclear pore complexes (NPCs) in the nuclear envelope and causes either a reduction in inner nuclear membrane (INM) proteins or their relocalization to the ER. TMEM170A interacts with RTN4, a member of the reticulon family; simultaneous co-silencing of TMEM170A and RTN4 rescues ER, NPC and nuclear-envelope-related phenotypes, implying that the two proteins have antagonistic effects on ER membrane organization, and nuclear envelope and NPC formation. PMID:26906412

  2. HIGH FILL-OUT, EXTREME MASS RATIO OVERCONTACT BINARY SYSTEMS. X. THE NEWLY DISCOVERED BINARY XY LEONIS MINORIS

    SciTech Connect

    Qian, S.-B.; Liu, L.; Zhu, L.-Y.; He, J.-J.; Bernasconi, L. E-mail: yygcn@163.com

    2011-05-15

    The newly discovered short-period close binary star, XY LMi, has been monitored photometrically since 2006. Its light curves are typical EW-type light curves and show complete eclipses with durations of about 80 minutes. Photometric solutions were determined through an analysis of the complete B, V, R, and I light curves using the 2003 version of the Wilson-Devinney code. XY LMi is a high fill-out, extreme mass ratio overcontact binary system with a mass ratio of q = 0.148 and a fill-out factor of f = 74.1%, suggesting that it is in the late evolutionary stage of late-type tidal-locked binary stars. As observed in other overcontact binary stars, evidence for the presence of two dark spots on both components is given. Based on our 19 epochs of eclipse times, we found that the orbital period of the overcontact binary is decreasing continuously at a rate of dP/dt = -1.67 x 10{sup -7} days yr{sup -1}, which may be caused by mass transfer from the primary to the secondary and/or angular momentum loss via magnetic stellar wind. The decrease of the orbital period may result in the increase of the fill-out, and finally, it will evolve into a single rapid-rotation star when the fluid surface reaches the outer critical Roche lobe.

  3. XMM-Newton analysis of a newly discovered, extremely X-ray luminous galaxy cluster at high redshift

    NASA Astrophysics Data System (ADS)

    Thoelken, S.; Schrabback, T.

    2016-06-01

    Galaxy clusters, the largest virialized structures in the universe, provide an excellent method to test cosmology on large scales. The galaxy cluster mass function as a function of redshift is a key tool to determine the fundamental cosmological parameters and especially measurements at high redshifts can e.g. provide constraints on dark energy. The fgas test as a direct cosmological probe is of special importance. Therefore, relaxed galaxy clusters at high redshifts are needed but these objects are considered to be extremely rare in current structure formation models. Here we present first results from an XMM-Newton analysis of an extremely X-ray luminous, newly discovered and potentially cool core cluster at a redshift of z=0.9. We carefully account for background emission and PSF effects and model the cluster emission in three radial bins. Our preliminary results suggest that this cluster is indeed a good candidate for a cool core cluster and thus potentially of extreme value for cosmology.

  4. Historical abiotic events or human-aided dispersal: inferring the evolutionary history of a newly discovered galaxiid fish

    PubMed Central

    Chakona, Gamuchirai; Swartz, Ernst R; Chakona, Albert

    2015-01-01

    Range expansion of obligate freshwater fishes in the Cape Floristic Region (CFR) of South Africa has mostly been attributed to river capture events and confluence of rivers following sea-level regression. The role of low drainage divides and interbasin water transfers has received less attention. This study analyzed mitochondrial and nuclear DNA sequences to assess the processes that could have influenced the phylogeographic patterns of a newly discovered lineage of Galaxias zebratus (hereafter Galaxias zebratus “Joubertina”) that occurs across two currently isolated river systems close to the Joubertina area in the eastern CFR. Results from both analyses revealed that observed genetic differentiation cannot be explained by isolation between the two river systems. No genetic differentiation was found between the Krom River system and a population from one of the Gamtoos tributaries. Shallow genetic differentiation was found between the Krom and the other Gamtoos populations. Historical river capture events and sea-level changes do not explain the present distribution of Galaxias zebratus “Joubertina” across the Krom and Gamtoos River systems. Interbasin dispersal during pluvial periods, recent river capture, or recent human-mediated translocation seems to be the most plausible explanations. PMID:25897377

  5. Historical abiotic events or human-aided dispersal: inferring the evolutionary history of a newly discovered galaxiid fish.

    PubMed

    Chakona, Gamuchirai; Swartz, Ernst R; Chakona, Albert

    2015-04-01

    Range expansion of obligate freshwater fishes in the Cape Floristic Region (CFR) of South Africa has mostly been attributed to river capture events and confluence of rivers following sea-level regression. The role of low drainage divides and interbasin water transfers has received less attention. This study analyzed mitochondrial and nuclear DNA sequences to assess the processes that could have influenced the phylogeographic patterns of a newly discovered lineage of Galaxias zebratus (hereafter Galaxias zebratus "Joubertina") that occurs across two currently isolated river systems close to the Joubertina area in the eastern CFR. Results from both analyses revealed that observed genetic differentiation cannot be explained by isolation between the two river systems. No genetic differentiation was found between the Krom River system and a population from one of the Gamtoos tributaries. Shallow genetic differentiation was found between the Krom and the other Gamtoos populations. Historical river capture events and sea-level changes do not explain the present distribution of Galaxias zebratus "Joubertina" across the Krom and Gamtoos River systems. Interbasin dispersal during pluvial periods, recent river capture, or recent human-mediated translocation seems to be the most plausible explanations.

  6. High pH microbial ecosystems in a newly discovered, ephemeral, serpentinizing fluid seep at Yanartaş (Chimera), Turkey

    PubMed Central

    Meyer-Dombard, D'Arcy R.; Woycheese, Kristin M.; Yargıçoğlu, Erin N.; Cardace, Dawn; Shock, Everett L.; Güleçal-Pektas, Yasemin; Temel, Mustafa

    2015-01-01

    Gas seeps emanating from Yanartaş (Chimera), Turkey, have been documented for thousands of years. Active serpentinization produces hydrogen and a range of carbon gases that may provide fuel for life. Here we report a newly discovered, ephemeral fluid seep emanating from a small gas vent at Yanartaş. Fluids and biofilms were sampled at the source and points downstream. We describe site conditions, and provide microbiological data in the form of enrichment cultures, Scanning electron microscopy (SEM), carbon and nitrogen isotopic composition of solids, and PCR screens of nitrogen cycle genes. Source fluids are pH 11.95, with a Ca:Mg of ~200, and sediments under the ignited gas seep measure 60°C. Collectively, these data suggest the fluid is the product of active serpentinization at depth. Source sediments are primarily calcite and alteration products (chlorite and montmorillonite). Downstream, biofilms are mixed with montmorillonite. SEM shows biofilms distributed homogeneously with carbonates. Organic carbon accounts for 60% of the total carbon at the source, decreasing downstream to <15% as inorganic carbon precipitates. δ13C ratios of the organic carbon fraction of solids are depleted (−25 to −28‰) relative to the carbonates (−11 to −20‰). We conclude that heterotrophic processes are dominant throughout the surface ecosystem, and carbon fixation may be key down channel. δ15N ratios ~3‰, and absence of nifH in extracted DNA suggest that nitrogen fixation is not occurring in sediments. However, the presence of narG and nirS at most locations and in enrichments indicates genomic potential for nitrate and nitrite reduction. This small seep with shallow run-off is likely ephemeral, but abundant preserved microterracettes in the outflow and the surrounding area suggest it has been present for some time. This site and others like it present an opportunity for investigations of preserved deep biosphere signatures, and subsurface-surface interactions

  7. The newly discovered Jurassic Tikiusaaq carbonatite-aillikite occurrence, West Greenland, and some remarks on carbonatite-kimberlite relationships

    NASA Astrophysics Data System (ADS)

    Tappe, Sebastian; Steenfelt, Agnete; Heaman, Larry M.; Simonetti, Antonio

    2009-11-01

    We discuss mineral chemistry data and report ten high-precision U-Pb (zircon, baddeleyite, pyrochlore, and perovskite) and Rb-Sr phlogopite ages for the newly discovered Tikiusaaq carbonatite intrusion and associated ultramafic dykes from the North Atlantic craton, West Greenland. At Tikiusaaq, massive dolomite-calcite carbonatite sheets intruded an 2 × 3 km area along a ductile shear zone between ca. 158 and 155 Ma. The accompanying carbonatite and carbonate-rich ultramafic silicate dykes were emplaced between ca. 165 and 157 Ma in close proximity to this carbonatite centre utilizing pre-existing brittle fractures. The deep volatile-rich magmatism at Tikiusaaq forms part of a larger Jurassic alkaline province in southern West Greenland and represents the earliest manifestation of rifting processes related to the opening of the Mesozoic-Cenozoic Labrador Sea Basin. Although the ultramafic silicate dykes macroscopically resemble hypabyssal kimberlites, they are identified as kimzeyite-bearing monticellite aillikites (carbonate-rich ultramafic lamprophyres) using a modern mineralogical-genetic classification. The overlapping emplacement ages of the carbonatite sheets and aillikite dykes, along with the carbonate-rich nature of the latter, suggest a genetic relationship between these magma types. The aillikites carry garnet peridotite xenoliths and have mineralogical characteristics of primitive magmas such as highly forsteritic olivine (up to Fo 90 mol%) and Cr-rich spinel (up to 46 wt.% Cr 2O 3) microphenocrysts; whereas the carbonatite sheets reveal a higher degree of differentiation such as Fe-rich dolomite compositions (up to 9 wt.% FeO). The initial findings reported here from Tikiusaaq suggest that a link between these magma types by an increasing degree of partial melting of a common carbonated upper mantle peridotite source region, as commonly envisaged for the compositionally similar Sarfartoq complex, is untenable. Rather, proto-aillikite magma may be

  8. Bio-mediated Fe-deposits Associated With a Newly Discovered Vent Field at the Mohns Ridge

    NASA Astrophysics Data System (ADS)

    Thorseth, I. H.; Pedersen, R. B.; Kruber, C.; Kosler, J.; Steinsbu, B. O.; Johannessen, T.; Ovreaas, L.

    2005-12-01

    Textural, mineralogical and chemical features of rust colored mounds and chimney-like structures of the newly discovered hydrothermal vent field at the Mohns Ridge have been investigated to clarify the genesis of the deposits. The deposited material has a highly porous microtexture of branching, twisted filaments resembling stalks of the iron-oxidising Gallionella sp, but other unidentified filamentous structures are also present. The material is loosely consolidated by thin lamina where the interspaces between the filaments are filled with granular to compact precipitates. The filaments and the compact interstitial material have a similar composition of mainly FeO and less SiO2, and electron diffraction reveal 2-line ferrihydrite. Fine-grained particles between filaments show in addition Mn-enrichment. The REE composition of the siliceous ferrihydrite deposits show a similar pattern to that of the basaltic crust, indicating that they formed from low-temperature hydrothermal fluids, derived from interactions between the basaltic crust and circulating seawater. The deposits are situated on hyaloclastite, which is cemented by silica and minor amounts (~1 vol%) of pyrite. The iron isotope ratios of individual sulphide crystals in the hyaloclastite vary between zero-slightly positive. The ferrihydrite deposits have an organic carbon content of 0.5 wt% with a delta 13C value of -21 ‰ and negative iron isotope ratios (delta 56Fe of -1.66 ‰ and delta 57Fe of -2.73 ‰), indicating bio-mediated filament formation and microbial fractionation of carbon and iron isotopes. This suggests colonization and growth of the iron oxidising bacterium Gallionella at the interface between the reduced vent fluid and the surrounding oxidized seawater, and successive nucleation and precipitation of ferrihydrite and amorphous silica on the microbial stalks, resulting in the formation of the mounds and chimneys. Results from ongoing molecular analyses and culturing may reveal if other

  9. Insights into methane dynamics from analysis of authigenic carbonates and chemosynthetic mussels at newly-discovered Atlantic Margin seeps

    USGS Publications Warehouse

    Prouty, Nancy G.; Sahy, Diana; Ruppel, Carolyn D.; Roark, E. Brendan; Condon, Dan; Brooke, Sandra; Ross, Steve W.; Demopoulos, Amanda W.J.

    2016-01-01

    The recent discovery of active methane venting along the US northern and mid-Atlantic margin represents a new source of global methane not previously accounted for in carbon budgets from this region. However, uncertainty remains as to the origin and history of methane seepage along this tectonically inactive passive margin. Here we present the first isotopic analyses of authigenic carbonates and methanotrophic deep-sea mussels, Bathymodiolus   sp., and the first direct constraints on the timing of past methane emission, based on samples collected at the upper slope Baltimore Canyon (∼385 m water depth) and deepwater Norfolk (∼1600 m) seep fields within the area of newly-discovered venting. The authigenic carbonates at both sites were dominated by aragonite, with an average  signature of −47‰, a value consistent with microbially driven anaerobic oxidation of methane-rich fluids occurring at or near the sediment–water interface. Authigenic carbonate U and Sr isotope data further support the inference of carbonate precipitation from seawater-derived fluids rather than from formation fluids from deep aquifers. Carbonate stable and radiocarbon ( and ) isotope values from living Bathymodiolus   sp. specimens are lighter than those of seawater dissolved inorganic carbon, highlighting the influence of fossil carbon from methane on carbonate precipitation. U–Th dates on authigenic carbonates suggest seepage at Baltimore Canyon between 14.7±0.6 ka to 15.7±1.6 ka, and at the Norfolk seep field between 1.0±0.7 ka to 3.3±1.3 ka, providing constraint on the longevity of methane efflux at these sites. The age of the brecciated authigenic carbonates and the occurrence of pockmarks at the Baltimore Canyon upper slope could suggest a link between sediment delivery during Pleistocene sea-level lowstand, accumulation of pore fluid overpressure from sediment compaction, and release of overpressure through subsequent venting. Calculations show that

  10. Geology and geochemistry of newly discovered Tertiary carbonatite occurrences near Villa Ahumada area, Basin and Range province, Chihuahua, northern Mexico

    NASA Astrophysics Data System (ADS)

    Nandigam, Ravi Chenchu

    This study targets some newly discovered carbonatite occurrences located in the eastern Mexican Basin and Range province, a few kilometers to the east of Villa Ahumada, Chihuahua. The region containing these occurrences experienced compression related to subduction of the Farallon plate until about 32 Ma that was followed by Basin and Range extension. Geological mapping (1:5,000 scale), petrography, study of drill hole cuttings and satellite images, and major and trace element chemical analyses were utilized to understand the intrusive style of the carbonatites, their mineralogy and petrogenesis. The carbonatites, named Yuca, Mariana and El Indio, collectively intrude limestones, granitic intrusives and subduction-related tuffs and lavas mainly as a stock, breccias and dikes. The Yuca carbonatite was emplaced as a 900-m diameter stock, 500 x 350 m breccia body, numerous dikes and networks of fracture fillings. Crosscutting field relationships at Yuca suggest at least two stages of carbonatite emplacement. At Mariana, carbonatite was emplaced as a 750 x 350 m breccia. Four out of nine reverse circulation drill holes penetrated and bottomed in the breccia at an average depth of about 300 m At El Indio, carbonatite was emplaced as a 20 m diameter breccia pipe and a 1m thick sill. Major minerals present are calcite, Fe-rich calcite and hematite. Sporadic presence of fluorite is common. At Mariana, two generations of grossular-rich garnets associated with limestones and granite porphyry respectively are recognized. It is inferred that garnets in granite porphyry represent metasomatic alteration due to the emplacement of carbonatite breccia. Parental magmas of Yuca carbonatites have undergone differentiation under low fO2 conditions during which they were progressively enriched in iron. The carbonatite compositional types recognized based on major element data, in the sequence of least to most highly differentiated, are (1) magnesio-, (2) calcio- and (3

  11. Insights into methane dynamics from analysis of authigenic carbonates and chemosynthetic mussels at newly-discovered Atlantic Margin seeps

    NASA Astrophysics Data System (ADS)

    Prouty, N. G.; Sahy, D.; Ruppel, C. D.; Roark, E. B.; Condon, D.; Brooke, S.; Ross, S. W.; Demopoulos, A. W. J.

    2016-09-01

    The recent discovery of active methane venting along the US northern and mid-Atlantic margin represents a new source of global methane not previously accounted for in carbon budgets from this region. However, uncertainty remains as to the origin and history of methane seepage along this tectonically inactive passive margin. Here we present the first isotopic analyses of authigenic carbonates and methanotrophic deep-sea mussels, Bathymodiolus sp., and the first direct constraints on the timing of past methane emission, based on samples collected at the upper slope Baltimore Canyon (∼385 m water depth) and deepwater Norfolk (∼1600 m) seep fields within the area of newly-discovered venting. The authigenic carbonates at both sites were dominated by aragonite, with an average δ13C signature of - 47 ‰, a value consistent with microbially driven anaerobic oxidation of methane-rich fluids occurring at or near the sediment-water interface. Authigenic carbonate U and Sr isotope data further support the inference of carbonate precipitation from seawater-derived fluids rather than from formation fluids from deep aquifers. Carbonate stable and radiocarbon (δ13C and Δ13C) isotope values from living Bathymodiolus sp. specimens are lighter than those of seawater dissolved inorganic carbon, highlighting the influence of fossil carbon from methane on carbonate precipitation. U-Th dates on authigenic carbonates suggest seepage at Baltimore Canyon between 14.7 ± 0.6 ka to 15.7 ± 1.6 ka, and at the Norfolk seep field between 1.0 ± 0.7 ka to 3.3 ± 1.3 ka, providing constraint on the longevity of methane efflux at these sites. The age of the brecciated authigenic carbonates and the occurrence of pockmarks at the Baltimore Canyon upper slope could suggest a link between sediment delivery during Pleistocene sea-level lowstand, accumulation of pore fluid overpressure from sediment compaction, and release of overpressure through subsequent venting. Calculations show that the

  12. Data base on physical observations of near-Earth asteroids and establishment of a network to coordinate observations of newly discovered near-Earth asteroids

    NASA Technical Reports Server (NTRS)

    Davis, D. R.; Chapman, C. R.; Campins, H.

    1990-01-01

    This program consists of two tasks: (1) development of a data base of physical observations of near-earth asteroids and establishment of a network to coordinate observations of newly discovered earth-approaching asteroids; and (2) a simulation of the surface of low-activity comets. Significant progress was made on task one and, and task two was completed during the period covered by this progress report.

  13. Newly Discovered Silicate Features in the Spectra of Young Warm Debris Disks: Probing Terrestrial Regions of Planetary Systems

    NASA Astrophysics Data System (ADS)

    Ballering, N.; Rieke, G.

    2014-03-01

    vary. The total mass of dust in each belt was expressed through the coefficients C2 and C3. The dust was assumed to consist of amorphous olivine (MgFeSiO4). Model Fν = C1•Bν(Tstar) + C2•Fν,belt(rin1,rout1,rexp1,amin1) + C3•Fν,belt(rin2,rout2,rexp2,amin2) We found previously undiscovered emission features in the spectra of several targets, listed below. Our model fits to these systems confirmed that these spectral signatures can arise from realistic disk models, and that this dust is located in the terrestrial regions of these systems. This is a subset of the full sample of warm disks with newly discovered spectral features to be published in Ballering et al. (2014). • HIP 26966 (HD 38206), a 30 Myr old A0 star. • HIP 41081 (HD 71043), a 30 Myr old A0 star. • HIP 2578 (HD 3003), a 30 Myr old A0 star. • HIP 66068 (HD 117665), a 20 Myr old A1/A2 star. • HIP 78641 (HD 143675), a 20 Myr old A5 star. • HIP 26395 (HD 37306), a 10 Myr old A2 star. • HIP 71271 (HD 127750), a 20 Myr old A0 star. • HIP 58220 (HD 103703), a 20 Myr old F3 star.

  14. Discover--Deepen--Do: A 3D Pedagogical Approach for Developing Newly Qualified Teachers as Professional Learners

    ERIC Educational Resources Information Center

    Graham, Sally; Lester, Nicola; Dickerson, Claire

    2012-01-01

    This article presents a strategy for teaching newly qualified teachers (NQTs) during their first year of teaching, developed by teacher educators from the University of Hertfordshire School of Education. The strategy included a new learning and teaching approach designed to enable NQTs to: develop as critically reflective teachers; build…

  15. Kanyawara Virus: A Novel Rhabdovirus Infecting Newly Discovered Nycteribiid Bat Flies Infesting Previously Unknown Pteropodid Bats in Uganda.

    PubMed

    Goldberg, Tony L; Bennett, Andrew J; Kityo, Robert; Kuhn, Jens H; Chapman, Colin A

    2017-07-13

    Bats are natural reservoir hosts of highly virulent pathogens such as Marburg virus, Nipah virus, and SARS coronavirus. However, little is known about the role of bat ectoparasites in transmitting and maintaining such viruses. The intricate relationship between bats and their ectoparasites suggests that ectoparasites might serve as viral vectors, but evidence to date is scant. Bat flies, in particular, are highly specialized obligate hematophagous ectoparasites that incidentally bite humans. Using next-generation sequencing, we discovered a novel ledantevirus (mononegaviral family Rhabdoviridae, genus Ledantevirus) in nycteribiid bat flies infesting pteropodid bats in western Uganda. Mitochondrial DNA analyses revealed that both the bat flies and their bat hosts belong to putative new species. The coding-complete genome of the new virus, named Kanyawara virus (KYAV), is only distantly related to that of its closest known relative, Mount Elgon bat virus, and was found at high titers in bat flies but not in blood or on mucosal surfaces of host bats. Viral genome analysis indicates unusually low CpG dinucleotide depletion in KYAV compared to other ledanteviruses and rhabdovirus groups, with KYAV displaying values similar to rhabdoviruses of arthropods. Our findings highlight the possibility of a yet-to-be-discovered diversity of potentially pathogenic viruses in bat ectoparasites.

  16. Seed germination of a newly discovered hyperaccumulator Solanum nigrum L. affected by illumination and seed-soaking reagent.

    PubMed

    Wei, Shuhe; Hu, Yahu; Srivastava, Mrittunjai; Zhou, Qixing; Niu, Rongcheng; Li, Yunmeng; Wu, Zhijie; Sun, Tieheng

    2009-10-30

    Solanum nigrum is a newly found Cd-hyperaccumulator which showed very high remediation efficiency in polluted soil. Seed germination experiments with different illumination and seed-soaking reagents were conducted in constant temperature box and greenhouse with soil as burgeon base. The results showed that the germination rate with alternating light/dark photoperiod was about twice of that without lighting (p < 0.05), suggesting that illumination is one of the important conditions for seed germination of S. nigrum. All treatments with seed-soaking reagents significantly increased the seed germination rate of S. nigrum (p < 0.05). Treatment with H2O2 (0.1%) had the shortest germination time. The germination rate of seeds that were not washed in water following soaking was 2-3 times higher than that of seeds that were washed after soaking.

  17. E/V Nautilus Detection of Isolated Features in the Eastern Pacific Ocean: Newly Discovered Calderas and Methane Seeps

    NASA Astrophysics Data System (ADS)

    Raineault, N.; Irish, O.; Lubetkin, M.

    2016-02-01

    The E/V Nautilus mapped over 80,000 km2 of the seafloor in the Gulf of Mexico and Eastern Pacific Ocean during its 2015 expedition. The Nautilus used its Kongsberg EM302 multibeam system to map the seafloor prior to remotely operated vehicle (ROV) dives, both for scientific purposes (site selection) and navigational safety. The Nautilus also routinely maps during transits to identify previously un-mapped or unresolved seafloor features. During its transit from the Galapagos Islands to the California Borderland, the Nautilus mapped 44,695 km2 of seafloor. Isolated features on the seafloor and in the water-column, such as calderas and methane seeps, were detected during this data collection effort. Operating at a frequency of 30 kHz in waters ranging from 1000-5500 m, we discovered caldera features off the coast of Central America. Since seamounts are known hotspots of biodiversity, locating new ones may enrich our understanding of seamounts as "stepping stones" for species distribution and ocean current pathways. Satellite altimetry datasets prior to this data either did not discern these calderas or recognized the presence of a bathymetric high without great detail. This new multibeam bathymetry data, gridded at 50 m, gives a precise look at these seamounts that range in elevation from 350 to 1400 m from abyssal depth. The largest of the calderas is circular in shape and is 10,000 m in length and 5,000 m in width, with a distinct circular depression at the center of its highest point, 1,400 m above the surrounding abyssal depth. In the California Borderland region, located between San Diego and Los Angeles, four new seeps were discovered in water depths from 400-1,020 m. ROV exploration of these seeps revealed vent communities. Altogether, these discoveries reinforce how little we know about the global ocean, indicate the presence of isolated deep-sea ecosystems that support biologically diverse communities, and will impact our understanding of seafloor habitat.

  18. Effect of fertilizer amendments on phytoremediation of Cd-contaminated soil by a newly discovered hyperaccumulator Solanum nigrum L.

    PubMed

    Wei, Shuhe; Li, Yunmeng; Zhou, Qixing; Srivastava, Mrittunjai; Chiu, Siuwai; Zhan, Jie; Wu, Zhijie; Sun, Tieheng

    2010-04-15

    Phytoremediation is a cost-effective, simple and sustainable beneficiary technique to purify the polluted environment. Solanum nigrum L., a newly found cadmium (Cd) hyperaccumulator, has shown the potential to remediate Cd-contaminated soils. Present study investigated the effects of fertilizer amendments on the Cd uptake by S. nigrum. Chicken manure and urea are usual agricultural fertilizers and more environmental friendly. The results showed that Cd concentrations in shoots of S. nigrum were significantly decreased (p<0.05) by 28.2-34.6%, as compared to that of without the addition of chicken manure, but not the case for urea treatment. However, Cd extraction capacities (microg pot(-1)) in shoot biomass of S. nigrum were significantly increased (p<0.05) due to increased shoot biomass. In addition, available Cd concentration in soil significantly decreased due to addition of chicken manure. Thus, urea might be a better fertilizer for strengthening phytoextraction rate of S. nigrum to Cd, and chicken manure may be a better fertilizer for phytostabilization.

  19. Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.

    PubMed

    Eminoğlu, Ayşenur; Vullo, Daniela; Aşık, Aycan; Çolak, Dilşat Nigar; Çanakçı, Sabriye; Beldüz, Ali Osman; Supuran, Claudiu T

    2016-04-01

    The genome of the newly identified bacterium Enterobacter sp. B13 encodes for a β-class carbonic anhydrases (CAs, EC 4.2.1.1), EspCA. This enzyme was recently cloned, and characterized kinetically by this group (J. Enzyme Inhib. Med. Chem. 2016, 31). Here we report an inhibition study with sulfonamides and sulfamates of this enzyme. The best EspCA inhibitors were some sulfanylated sulfonamides with elongated molecules, metanilamide, 4-aminoalkyl-benzenesulfonamides, acetazolamide, and deacetylated methazolamide (KIs in the range of 58.7-96.5nM). Clinically used agents such as methazolamide, ethoxzolamide, dorzolamide, brinzolamide, benzolamide, zonisamide, sulthiame, sulpiride, topiramate and valdecoxib were slightly less effective inhibitors (KIs in the range of 103-138nM). Saccharin, celecoxib, dichlorophenamide and many simple benzenesulfonamides were even less effective as EspCA inhibitors, with KIs in the range of 384-938nM. Identification of effective inhibitors of this bacterial enzyme may lead to pharmacological tools useful for understanding the physiological role(s) of the β-class CAs in bacterial pathogenicity/virulence.

  20. Study of the newly discovered isotopologue 628 CO2 molecule band with PFS-MeX at Mars

    NASA Astrophysics Data System (ADS)

    Geminale, Anna

    Recently a new band of the isotopologue 628 molecule of CO2 has been discovered by SPICAV SOIR (Bertaux et al., 2007, in press) at Venus (on board Venus Express mission) and at Mars by ground based observations (Villanueva et al., 2007, in press). The Planetary Fourier Spectrometer (PFS) presently orbiting Mars on board of the ESA mission Mars Express (Formisano et al., 2005) has been observing this band since 2004, when was first switched on. Here we study a Martian average spectrum (86 000 measurements) which shows the main CO2 isotopologue 628 (16O12C18O) at several classical bands and at 2982 cm-1(the band not contained in Hitran). We shall discuss the mixing ratio, obtained by the classical bands, versus the line intensities needed to fit with a synthetic spectrum the new band. From the study of the residuals, it appears that even the minor lines have been seen by the PFS experiment. References Formisano, V. et al., 2005. The Planetary Fourier Spectrometer (PFS) onboard the European Mars Express mission. Planetary and Space Science 53, 963-974.

  1. Rapid forest clearing in a Myanmar proposed national park threatens two newly discovered species of geckos (Gekkonidae: Cyrtodactylus).

    PubMed

    Connette, Grant M; Oswald, Patrick; Thura, Myint Kyaw; LaJeunesse Connette, Katherine J; Grindley, Mark E; Songer, Melissa; Zug, George R; Mulcahy, Daniel G

    2017-01-01

    Myanmar's recent transition from military rule towards a more democratic government has largely ended decades of political and economic isolation. Although Myanmar remains heavily forested, increased development in recent years has been accompanied by exceptionally high rates of forest loss. In this study, we document the rapid progression of deforestation in and around the proposed Lenya National Park, which includes some of the largest remaining areas of lowland evergreen rainforest in mainland Southeast Asia. The globally unique forests in this area are rich in biodiversity and remain a critical stronghold for many threatened and endangered species, including large charismatic fauna such as tiger and Asian elephant. We also conducted a rapid assessment survey of the herpetofauna of the proposed national park, which resulted in the discovery of two new species of bent-toed geckos, genus Cyrtodactylus. We describe these new species, C. lenya sp. nov. and C. payarhtanensis sp. nov., which were found in association with karst (i.e., limestone) rock formations within mature lowland wet evergreen forest. The two species were discovered less than 35 km apart and are each known from only a single locality. Because of the isolated nature of the karst formations in the proposed Lenya National Park, these geckos likely have geographical ranges restricted to the proposed protected area and are threatened by approaching deforestation. Although lowland evergreen rainforest has vanished from most of continental Southeast Asia, Myanmar can still take decisive action to preserve one of the most biodiverse places on Earth.

  2. Jet power and feedback from the newly-discovered radio/optical/X-ray microquasar S26 in NGC 7793

    NASA Astrophysics Data System (ADS)

    Soria, Roberto; Corbel, Stephane; Pakull, Manfred; Motch, Christian

    2009-07-01

    We have discovered an exceptional radio/optical/X-ray microquasar in the Sculptor galaxy NGC7793 (distance of 3.4 Mpc), with a large (300 x 150 pc) shock-ionized bubble, and X-ray hot spots where the collimated jet hits the interstellar medium. The radio nebula has an integrated flux of 1.2 mJy at 6 cm (more luminous than Cas A). The system resembles the famous Galactic microquasar SS433, but on an even grander scale. We propose deeper radio observations at higher spatial resolution with the ATCA: to identify the radio hot spots; to infer the jet power from the synchrotron luminosity of the hot spots; to determine the shape of the radio cocoon and compare it with the H-alpha, HeII 4686 and X-ray nebulae; to estimate the total (integrated) energy injected in the nebula by the jet/wind, and constrain its age; to search for the radio core. Our combined radio, X-ray and optical study of this source will help us model the radiative and mechanical power budget of accreting black holes, and their feedback onto the interstellar or intergalactic medium.

  3. Rapid forest clearing in a Myanmar proposed national park threatens two newly discovered species of geckos (Gekkonidae: Cyrtodactylus)

    PubMed Central

    Oswald, Patrick; Thura, Myint Kyaw; LaJeunesse Connette, Katherine J.; Grindley, Mark E.; Songer, Melissa; Zug, George R.; Mulcahy, Daniel G.

    2017-01-01

    Myanmar’s recent transition from military rule towards a more democratic government has largely ended decades of political and economic isolation. Although Myanmar remains heavily forested, increased development in recent years has been accompanied by exceptionally high rates of forest loss. In this study, we document the rapid progression of deforestation in and around the proposed Lenya National Park, which includes some of the largest remaining areas of lowland evergreen rainforest in mainland Southeast Asia. The globally unique forests in this area are rich in biodiversity and remain a critical stronghold for many threatened and endangered species, including large charismatic fauna such as tiger and Asian elephant. We also conducted a rapid assessment survey of the herpetofauna of the proposed national park, which resulted in the discovery of two new species of bent-toed geckos, genus Cyrtodactylus. We describe these new species, C. lenya sp. nov. and C. payarhtanensis sp. nov., which were found in association with karst (i.e., limestone) rock formations within mature lowland wet evergreen forest. The two species were discovered less than 35 km apart and are each known from only a single locality. Because of the isolated nature of the karst formations in the proposed Lenya National Park, these geckos likely have geographical ranges restricted to the proposed protected area and are threatened by approaching deforestation. Although lowland evergreen rainforest has vanished from most of continental Southeast Asia, Myanmar can still take decisive action to preserve one of the most biodiverse places on Earth. PMID:28403189

  4. Newly discovered uranium mineralization at 2.0 Ma in the Menggongjie granite-hosted uranium deposit, South China

    NASA Astrophysics Data System (ADS)

    Luo, Jin-Cheng; Hu, Rui-Zhong; Fayek, Mostafa; Bi, Xian-Wu; Shi, Shao-Hua; Chen, You-Wei

    2017-04-01

    The southeastern part of the Nanling metallogenic province, South China contains numerous economically important granite-hosted, hydrothermal vein-type uranium deposits. The Miao'ershan (MES) uranium ore field is one of the most important uranium sources in China, hosts the largest Chanziping carbonaceous-siliceous-pelitic rock-type uranium deposit and several representative granite-hosted uranium deposits. The geology and geochemistry of these deposits have been extensively studied. However, accurate and precise ages for the uranium mineralization are scarce because uranium minerals in these deposits are usually fine-grained, and may have formed in several stages, thus hindering the understanding of the uranium metallogenesis of this province. The Menggongjie (MGJ) uranium deposit is one of the largest granite-hosted uranium deposits in the MES ore field. Uranium mineralization in this deposit occurs at the central part of the MES granitic complex, accompanied with silicification, fluorination, K-metasomatism and hematitization. The ore minerals are dominated by uraninite, occurring in quartz or fluorite veinlets along fractures in altered granite. In-situ SIMS U-Pb dating on the uraninite yields the U-Pb isotopic age of 1.9 ± 0.7 Ma, which is comparable to the chemical U-Th-Pbtol uraninite age of 2.3 ± 0.1 Ma. Such ages agree well with the eruption ages of the extension-related Quaternary volcanics (2.1-1.2 Ma) in South China, suggesting that the uranium mineralization have formed at an extensional setting, possibly related to the Quaternary volcanic activities. Therefore, our robust, new dating results of the MGJ uranium deposit make it the youngest granite-hosted uranium deposit reported so far in South China and the mineralization event represents a newly identified mineralization epoch.

  5. Phenomenological Modeling of Newly Discovered Eclipsing Binary 2MASS J18024395 + 4003309 = VSX J180243.9+400331

    NASA Astrophysics Data System (ADS)

    Andronov, Ivan L.; Kim, Yonggi; Kim, Young-Hee; Yoon, Joh-Na; Chinarova, Lidia L.; Tkachenko, Mariia G.

    2015-06-01

    We present a by-product of our long term photometric monitoring of cataclysmic variables. 2MASS J18024395 +4003309 = VSX J180243.9 +400331 was discovered in the field of the intermediate polar V1323 Her observed using the Korean 1-m telescope located at Mt. Lemmon, USA. An analysis of the two-color VR CCD observations of this variable covers all the phase intervals for the first time. The light curves show this object can be classified as an Algol-type variable with tidally distorted components, and an asymmetry of the maxima (the O'Connell effect). The periodogram analysis confirms the cycle numbering of Andronov et al. (2012) and for the initial approximation, the ephemeris is used as follows: Min I. BJD = 2456074.4904+0.3348837E . For phenomenological modeling, we used the trigonometric polynomial approximation of statistically optimal degree, and a recent method "NAV" ("New Algol Variable") using local specific shapes for the eclipse. Methodological aspects and estimates of the physical parameters based on analysis of phenomenological parameters are presented. As results of our phenomenological model, we obtained for the inclination i=90°, M1=0.745M⊙, M2=0.854M⊙, M=M1+M2=1.599M⊙, the orbital separation a=1.65°109m=2.37R⊙ and relative radii r1=R1/a=0.314 and r2=R2/a=0.360. These estimates may be used as preliminary starting values for further modeling using extended physical models based on the Wilson & Devinney (1971) code and it's extensions

  6. Deep-water carbonate slope failure events in a newly discovered Silurian basin, Blue Ridge province, southern Appalachians, Tennessee

    SciTech Connect

    Unrug, R. )

    1991-03-01

    Siliciclastic deep-water turbidites of the Walden Creek Group, Ocoee Supergroup, underlying the foothills of the Great Smoky Mountains, contain olistolith blocks and olistostromal debris-flow breccia beds. Paleozoic fossils discovered recently in the olistoliths indicate Silurian age of the carbonates. The Walden Creek Group is therefore Silurian or younger, not late Proterozoic in age, as believed previously. The carbonate olistoliths and breccias formed by collapse of post-Taconic Silurian carbonate-dominated basin present in the Blue Ridge province of the Southern Appalachians into the younger basin of the Walden Creek Group. Two modes of occurrence of the olistoliths are present: (1) discrete horizons in which olistoliths are sitting spaced ten to hundreds of meters apart underneath a widespread conglomerate bed and (2) accumulations of olistoliths in localized stacked horizons in the vertical sequence of the enclosing siliciclastic rocks. Both modes can be related to failure of active fault scarps. Rocks of the olistolith are lithologically varied and record an older event of slope failure within the Silurian carbonate-dominated basin. Three facies assemblages representing two sedimentary environments are present in the olistoliths. Facies assemblage A includes oolitic limestone, stromatolite, carbonate breccia encrusted by stromatolite, and massive sandy limestone. It represents a high-energy, shallow-water, carbonate platform environment. Facies assemblage B consists of bedded dark limestone, alternating with black shale, and represents sediments of the carbonate platform slope. Facies assemblage C includes carbonate breccias intercalated in the bedded limestones and shales and is interpreted as deposits of the lower slope formed by failure of the carbonate platform margin.

  7. Phylogeography and genetic identification of the newly-discovered populations of torrent salamanders (Rhyacotriton cascade and R. variegatus) in the central Cascades (USA)

    USGS Publications Warehouse

    Wagner, R.S.; Miller, Mark P.; Haig, Susan M.

    2006-01-01

    Newly discovered populations of Rhyacotritonidae were investigated for taxonomic identity, hybridization, and sympatry. Species in the genus Rhyacotriton have been historically difficult to identify using morphological characters. Mitochondrial (mtDNA) 16S ribosomal RNA sequences (491 bp) and allozymes (6 loci) were used to identify the distribution of populations occurring intermediate between the previously described ranges of R. variegatus and R. cascadae in the central Cascade Mountain region of Oregon. Allozyme and mitochondrial sequence data both indicated the presence of two distinct evolutionary lineages, with each lineage corresponding to the allopatric distribution of R. cascadae and R. variegatus. Results suggest the Willamette River acts as a phylogeographic barrier limiting the distribution of both species, although we cannot exclude the possibility that reproductive isolation also exists that reinforces species' distributions. This study extends the previously described geographical ranges of both R. cascadae and R. variegatus and defines an eastern range limit for R. variegatus conservation efforts.

  8. First orbital solution and evolutionary state for the newly discovered eclipsing binaries USNO-B1.0 1091-0130715 and GSC-03449-0680

    NASA Astrophysics Data System (ADS)

    Elkhateeb, M. M.; Nouh, M. I.; Nelson, R. H.

    2015-02-01

    A first photometric study for the newly discovered systems USNO-B1.0 1091-0130715 and GSC-03449-0680 was carried out by means of recent a windows interface version of the Wilson and Devinney code based on model atmospheres by Kurucz (1993). The accepted models reveal some absolute parameters for both systems, which are used in deriving the spectral type of the system components and their evolutionary status. Distances to each systems and physical properties were estimated. Comparisons of the computed physical parameters with stellar models are discussed. The components of the system USNO-B1.0 1091-0130715 and the primary of the system GSC-03449-0680 are found to be on or near the ZAMS track, while the secondary of GSC-03449-0680 system found to be severely under luminous and too cool compared to its ZAMS mass.

  9. Maar-diatreme volcanism relating to the pyroclastic sequence of a newly discovered high-alumina basalt in the Maroa Volcanic Centre, Taupo Volcanic Zone, New Zealand

    NASA Astrophysics Data System (ADS)

    Kósik, S.; Németh, K.; Procter, J. N.; Zellmer, G. F.

    2017-07-01

    Diatreme sequences have previously been described from drill holes within the Taupo Volcanic Zone. The newly discovered Te Hukui Basalt exhibits deep excavation of country rocks that do not appear elsewhere at the surface. The basalt is characterized by proximal deposition of pyroclastic deposits relating to phreatomagmatism. The geochemical composition classifies these rocks as high-alumina basalts. They erupted along the Orakeikorako Fault at the same location where rhyolitic activity of Puketerata occurred at a later point in time. The petrological characteristics of the basalts indicate the mixing of mafic melt with crystalline mush relating to more evolved magmas. The new basaltic occurrence supports frequent mafic recharge of shallow magma reservoirs, inducing basaltic eruptions, in this case the mafic magma intruding into highly crystallized mush zones. This may explain why basaltic eruptions mostly occur on the edge of the central extensional part of the Taupo Volcanic Zone.

  10. Long-term mortality after community-acquired pneumonia—impacts of diabetes and newly discovered hyperglycaemia: a prospective, observational cohort study

    PubMed Central

    Koskela, Heikki O; Salonen, Päivi H; Romppanen, Jarkko; Niskanen, Leo

    2014-01-01

    Objectives Community-acquired pneumonia is associated with a significant long-term mortality after initial recovery. It has been acknowledged that additional research is urgently needed to examine the contributors to this long-term mortality. The objective of the present study was to assess whether diabetes or newly discovered hyperglycaemia during pneumonia affects long-term mortality. Design A prospective, observational cohort study. Setting A single secondary centre in eastern Finland. Participants 153 consecutive hospitalised patients who survived at least 30 days after mild-to-moderate community-acquired pneumonia. Interventions Plasma glucose levels were recorded seven times during the first day on the ward. Several possible confounders were also recorded. The surveillance status and causes of death were recorded after median of 5 years and 11 months. Results In multivariate Cox regression analysis, a previous diagnosis of diabetes among the whole population (adjusted HR 2.84 (1.35–5.99)) and new postprandial hyperglycaemia among the non-diabetic population (adjusted HR 2.56 (1.04–6.32)) showed independent associations with late mortality. New fasting hyperglycaemia was not an independent predictor. The mortality rates at the end of follow-up were 54%, 37% and 10% among patients with diabetes, patients without diabetes with new postprandial hyperglycaemia and patients without diabetes without postprandial hyperglycaemia, respectively (p<0.001). The underlying causes of death roughly mirrored those in the Finnish general population with a slight excess in mortality due to chronic respiratory diseases. Pneumonia was the immediate cause of death in just 8% of all late deaths. Conclusions A previous diagnosis of diabetes and newly discovered postprandial hyperglycaemia increase the risk of death for several years after community-acquired pneumonia. As the knowledge about patient subgroups with an increased late mortality risk is gradually gathering

  11. [Theories of medicine in the newly discovered medical book "Hon'po Kagen Hishu" by San'ki Tashiro: basic prescriptions and modified prescriptions].

    PubMed

    Endo, J; Nakamura, T

    2001-12-01

    While investigating the formation of the Gosei-ha school in Japan by Tashiro San'ki and Manase Dosan, we discovered "Hon'po Kagen Hishu", a heretofore unknown medical book by San'ki Tashiro. A comparison of this work with Sanki's "Wakyokushu" revealed the following points. (1) "Hon'po Kagen Hishu" is a medical book compiled by San'ki Tashiro, and is believed to have been put together after the newly-compiled "Wakyokushu" (1525). (2) The book is roughly divided into two parts: basic prescriptions and modified prescriptions. "Hon'po Kagen Hishu" reveals clearly that San'ki's medical theories form the key theories of these two parts. (3) Many of the basic prescriptions contained in "Hon'po Kagen Hishu" were existing prescriptions used by the Kyokuho-ha School which was popular in Japan at the time. The modified prescriptions conform to the bian zheng pei ji (selection of drug based on the differential diagnosis) theories of the Li-Zhu medical school. (4) Among the 15 prescriptions described in the 'Shobyou Tsuyo no Yakuho' chapter of "Hon'po Kagen Hisku" secret prescriptions from schools of thought including the Nakarai school were discovered, pointing to a connection between San'ki and the Nakarai school.

  12. Nitrogen Removal Characteristics of a Newly Isolated Indigenous Aerobic Denitrifier from Oligotrophic Drinking Water Reservoir, Zoogloea sp. N299.

    PubMed

    Huang, Ting-Lin; Zhou, Shi-Lei; Zhang, Hai-Han; Bai, Shi-Yuan; He, Xiu-Xiu; Yang, Xiao

    2015-05-04

    Nitrogen is considered to be one of the most widespread pollutants leading to eutrophication of freshwater ecosystems, especially in drinking water reservoirs. In this study, an oligotrophic aerobic denitrifier was isolated from drinking water reservoir sediment. Nitrogen removal performance was explored. The strain was identified by 16S rRNA gene sequence analysis as Zoogloea sp. N299. This species exhibits a periplasmic nitrate reductase gene (napA). Its specific growth rate was 0.22 h-1. Obvious denitrification and perfect nitrogen removal performances occurred when cultured in nitrate and nitrite mediums, at rates of 75.53%±1.69% and 58.65%±0.61%, respectively. The ammonia removal rate reached 44.12%±1.61% in ammonia medium. Zoogloea sp. N299 was inoculated into sterilized and unsterilized reservoir source waters with a dissolved oxygen level of 5-9 mg/L, pH 8-9, and C/N 1.14:1. The total nitrogen removal rate reached 46.41%±3.17% (sterilized) and 44.88%±4.31% (unsterilized). The cell optical density suggested the strain could survive in oligotrophic drinking water reservoir water conditions and perform nitrogen removal. Sodium acetate was the most favorable carbon source for nitrogen removal by strain N299 (p<0.05). High C/N was beneficial for nitrate reduction (p<0.05). The nitrate removal efficiencies showed no significant differences among the tested inoculums dosage (p>0.05). Furthermore, strain N299 could efficiently remove nitrate at neutral and slightly alkaline and low temperature conditions. These results, therefore, demonstrate that Zoogloea sp. N299 has high removal characteristics, and can be used as a nitrogen removal microbial inoculum with simultaneous aerobic nitrification and denitrification in a micro-polluted reservoir water ecosystem.

  13. Nitrogen Removal Characteristics of a Newly Isolated Indigenous Aerobic Denitrifier from Oligotrophic Drinking Water Reservoir, Zoogloea sp. N299

    PubMed Central

    Huang, Ting-Lin; Zhou, Shi-Lei; Zhang, Hai-Han; Bai, Shi-Yuan; He, Xiu-Xiu; Yang, Xiao

    2015-01-01

    Nitrogen is considered to be one of the most widespread pollutants leading to eutrophication of freshwater ecosystems, especially in drinking water reservoirs. In this study, an oligotrophic aerobic denitrifier was isolated from drinking water reservoir sediment. Nitrogen removal performance was explored. The strain was identified by 16S rRNA gene sequence analysis as Zoogloea sp. N299. This species exhibits a periplasmic nitrate reductase gene (napA). Its specific growth rate was 0.22 h−1. Obvious denitrification and perfect nitrogen removal performances occurred when cultured in nitrate and nitrite mediums, at rates of 75.53% ± 1.69% and 58.65% ± 0.61%, respectively. The ammonia removal rate reached 44.12% ± 1.61% in ammonia medium. Zoogloea sp. N299 was inoculated into sterilized and unsterilized reservoir source waters with a dissolved oxygen level of 5–9 mg/L, pH 8–9, and C/N 1.14:1. The total nitrogen removal rate reached 46.41% ± 3.17% (sterilized) and 44.88% ± 4.31% (unsterilized). The cell optical density suggested the strain could survive in oligotrophic drinking water reservoir water conditions and perform nitrogen removal. Sodium acetate was the most favorable carbon source for nitrogen removal by strain N299 (p < 0.05). High C/N was beneficial for nitrate reduction (p < 0.05). The nitrate removal efficiencies showed no significant differences among the tested inoculums dosage (p > 0.05). Furthermore, strain N299 could efficiently remove nitrate at neutral and slightly alkaline and low temperature conditions. These results, therefore, demonstrate that Zoogloea sp. N299 has high removal characteristics, and can be used as a nitrogen removal microbial inoculum with simultaneous aerobic nitrification and denitrification in a micro-polluted reservoir water ecosystem. PMID:25946341

  14. Long-term mortality after community-acquired pneumonia--impacts of diabetes and newly discovered hyperglycaemia: a prospective, observational cohort study.

    PubMed

    Koskela, Heikki O; Salonen, Päivi H; Romppanen, Jarkko; Niskanen, Leo

    2014-08-21

    Community-acquired pneumonia is associated with a significant long-term mortality after initial recovery. It has been acknowledged that additional research is urgently needed to examine the contributors to this long-term mortality. The objective of the present study was to assess whether diabetes or newly discovered hyperglycaemia during pneumonia affects long-term mortality. A prospective, observational cohort study. A single secondary centre in eastern Finland. 153 consecutive hospitalised patients who survived at least 30 days after mild-to-moderate community-acquired pneumonia. Plasma glucose levels were recorded seven times during the first day on the ward. Several possible confounders were also recorded. The surveillance status and causes of death were recorded after median of 5 years and 11 months. In multivariate Cox regression analysis, a previous diagnosis of diabetes among the whole population (adjusted HR 2.84 (1.35-5.99)) and new postprandial hyperglycaemia among the non-diabetic population (adjusted HR 2.56 (1.04-6.32)) showed independent associations with late mortality. New fasting hyperglycaemia was not an independent predictor. The mortality rates at the end of follow-up were 54%, 37% and 10% among patients with diabetes, patients without diabetes with new postprandial hyperglycaemia and patients without diabetes without postprandial hyperglycaemia, respectively (p<0.001). The underlying causes of death roughly mirrored those in the Finnish general population with a slight excess in mortality due to chronic respiratory diseases. Pneumonia was the immediate cause of death in just 8% of all late deaths. A previous diagnosis of diabetes and newly discovered postprandial hyperglycaemia increase the risk of death for several years after community-acquired pneumonia. As the knowledge about patient subgroups with an increased late mortality risk is gradually gathering, more studies are needed to evaluate the possible postpneumonia interventions to

  15. The Eugen Seibold coral mounds offshore western Morocco: oceanographic and bathymetric steering of a newly discovered cold-water coral province

    NASA Astrophysics Data System (ADS)

    Glogowski, Silke; Dullo, Christian; Flögel, Sascha; Feldens, Peter; Hühnerbach, Veit; von Reumont, Jonas; Krastel, Sebastian; Wynn, Russ B.; Liebetrau, Volker

    2015-04-01

    This study presents new seafloor bathymetric and sidescan sonar data identifying a previously unknown cold-water coral (CWC) province on the Atlantic margin off western Morocco (ca. 31° N). Applying the concept of seawater density as a predictive tool for living CWC reef occurrence during research cruise 32 aboard RV Maria S. Merian in October 2013 CTD casts revealed potential sites. Direct sampling retrieved living coral patches within an extensive field of carbonate mounds, covering an area of ~410 km2 on the upper slope ~40 nautical miles north of Agadir Canyon. Individual mounds are up to 12 m high and are mainly composed of dead cold-water corals Lophelia pertusa thickets at present-day water depths of 678-863 m. Living CWCs represent only a thin veneer and were sampled by box coring in the shallower parts of the mound field between 678 and 719 m. CTD measurements in these shallower areas revealed that the occurrence of these living CWC reefs coincides with the deeper part of the North Atlantic Central Water (NACW) mass exhibiting conservative temperatures Φ of 9.78-9.94° C, absolute salinity SA of 35.632 g/kg, and a sea water density σΦ of 27.31-27.33 kg/m3). This is in good agreement with observations from the Renard Ridge (35° N, Gulf of Cadiz) to the north and sites off Mauretania (17° N-18° N) to the south, 'with the exception of sparse live corals in the latter region, the CWC reefs of both regions consist of a dead fabric in the deeper layer of the NACW slightly above the Mediterranean Outflow Water. The bathymetric and oceanographic settings of this newly discovered CWC site, with its thin veneer of living corals and much larger accumulations of coral rubble, are consistent with published evidence that, over the past three glacial-interglacial cycles, active CWC reef growth south of 50° N was more favourable during glacial times (possibly up to the very early Holocene) in this sector of the northeast Atlantic Ocean. The newly discovered

  16. Protolith, metamorphic history and tectonic implications of newly discovered Triassic eclogites in the east-central Qiangtang: Evidences from mineralogy, geochemistry, Sr-Nd isotope, and geochronology

    NASA Astrophysics Data System (ADS)

    Jin, X.; Liu, J. M.; Zhou, X. Y.; Zhang, Y.

    2016-12-01

    The Triassic west-central Qiangtang metamorphic belt, consisting of blueschist- and eclogite-bearing mélange, whereas there are no eclogites reported in the east-central Qiangtang. In this study, geochemical, Sr-Nd isotopic, and geochronological methods, together with geothermobarometers, are used to reveal the protolith, metamorphic conditions, and tectonic implications of newly discovered (U)HP eclogites in east-cental Qiangtang, central Tibetan Plateau. These eclgites are mainly composed of garnet, omphacite, rutile, phengite, and amphibole. According to the Sr-Nd isotopic ratios [(87Sr/86Sr)i value: 0.7078 0.7086; ɛNd(t) value: -0.58 +1.96], the protoliths of eclogites were originated from depleted mantle and experienced continental crustal contamination. The REEs and HFSEs are immobile, so they are employed to discriminate the protolith and tectonic environments. In the Hf/3-Th-Ta diagram, most samples are ploted in island arc basalts and E-MORB fields. These eclogites also display arc-related features (Nb, Ta negative anomalies, high LREE/HREE ratios), and enriched MORB-like geological characteristics (flat REE patterns without Nb, Ta negative anomalies), respectively. In addition, compared with the north Anduo backarc basin basalts (BABB), and the Qilian eclogites (BABB as protolith), the protoliths are suggested to form in backarc basin for the similarity. Zircons in eclogite show no oscillatory zoning, possibly due to the high grade metamorphic conditions of 2.7 GPa / 742 °, which are acquired by Grt-Omp-Phe geothermobarometers. Subsequently, it experienced retragrade metamorphism, characterized by the decomposition of rutile, garnet, and omphacite. The coesite pseudomorph in garnet is also consistent with the peak metamorphic conditions. Eight zircons with low Th/U ratios defined concordant age of 223 ± 11 Ma, representing the age of peak metamorphism. In conclusion, the newly discovered eclogites formed in backarc basin, and consequently subducted

  17. Feasibility of dsRNA treatment for post-clearing SPF shrimp stocks of newly discovered viral infections using Laem Singh virus (LSNV) as a model.

    PubMed

    Saksmerprome, Vanvimon; Charoonnart, Patai; Flegel, Timothy W

    2017-05-02

    Using post-larvae derived from specific pathogen free (SPF) stocks in penaeid shrimp farming has led to a dramatic increase in production. At the same time, new pathogens of farmed shrimp are continually being discovered. Sometimes these pathogens are carried by shrimp and other crustaceans as persistent infections without gross signs of disease. Thus it is that a 5-generation stock of Penaeus monodon SPF for several pathogens was found, post-stock-development, to be persistently-infected with newly-discovered Laem Singh virus (LSNV). In this situation, the stock developers were faced with destroying their existing stock (developed over a long period at considerable cost) and starting the whole stock development process anew in order to add LSNV to its SPF list. As an alternative, it was hypothesized that injection of complementary dsRNA into viral-infected broodstock prior to mating might inhibit replication of the target virus sufficiently to reduce or eliminate its transmission to their offspring. Subsequent selection of uninfected offspring would allow for post-clearing of LSNV from the existing stock and for conversion of the stock to LSNV-free status. Testing this hypothesis using the LSNV-infected stock described above, we found that transmission was substantially reduced in several treated broodstock compared to much higher transmission in buffer-injected broodstock. Based on these results, the model is proposed for post-clearing of SPF stocks using dsRNA treatment. The model may also be applicable to post-clearing of exceptional, individual performers from grow-out ponds for return to a nucleus breeding center. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Ammonium removal at low temperature by a newly isolated heterotrophic nitrifying and aerobic denitrifying bacterium Pseudomonas fluorescens wsw-1001.

    PubMed

    Zhang, Shumei; Sha, Changqing; Jiang, Wei; Li, Weiguang; Zhang, Duoying; Li, Jing; Meng, Liqiang; Piao, Yongjian

    2015-01-01

    A heterotrophic nitrifier wsw-1001 was isolated from Songhua River and identified as Pseudomonas fluorescens. Ammonium removal by the strain at low temperature was investigated. The effect of initial ammonium concentration (from 5 to 1000 mg/L) and culture temperature (from 4°C to 30°C) on ammonium removal efficiency was studied. Biodegradation product, [Formula: see text], [Formula: see text], N2, N2O and intercellular N were monitored. The results indicated that the strain had potential for water and wastewater treatment. Ammonium could be removed by the strain at low temperature. Ammonium removal efficiency increased with temperature from 4°C to 20°C and decreased with ammonium concentration from 5 to 1000 mg/L. The strain exhibited a capability of heterotrophic nitrification and aerobic denitrification using [Formula: see text] as the sole nitrogen source at 8°C. [Formula: see text] and [Formula: see text] were reduced by the strain. Nitrogen balance analysis in the presence of 39.7 mg/L [Formula: see text] indicated that 71.2% [Formula: see text] was removed by converting to N2 (46.3%) and assimilating as biomass (42.5%). Substances such as [Formula: see text], [Formula: see text] and N2O were detected at very low concentrations. Ammonium mono-oxygenase, hydroxylamine oxidase, nitrite reductase and nitrate reductase activity were measured. The ammonium removal pathway of the strain was speculated to be [Formula: see text].

  19. The Environmental Impacts on the Star Formation Main Sequence: An Hα Study of the Newly Discovered Rich Cluster at z = 1.52

    NASA Astrophysics Data System (ADS)

    Koyama, Yusei; Kodama, Tadayuki; Tadaki, Ken-ichi; Hayashi, Masao; Tanaka, Ichi; Shimakawa, Rhythm

    2014-07-01

    We report the discovery of a strong over-density of galaxies in the field of a radio galaxy at z = 1.52 (4C 65.22) based on our broadband and narrow-band (Hα) photometry with the Subaru Telescope. We find that Hα emitters are located in the outskirts of the density peak (cluster core) dominated by passive red-sequence galaxies. This resembles the situation in lower-redshift clusters, suggesting that the newly discovered structure is a well-evolved rich galaxy cluster at z = 1.5. Our data suggest that the color-density and stellar mass-density relations are already in place at z ~ 1.5, mostly driven by the passive red massive galaxies residing within rc lsim 200 kpc from the cluster core. These environmental trends almost disappear when we consider only star-forming (SF) galaxies. We do not find SFR-density or SSFR-density relations amongst SF galaxies, and the location of the SF main sequence does not significantly change with environment. Nevertheless, we find a tentative hint that star-bursting galaxies (up-scattered objects from the main sequence) are preferentially located in a small group at ~1 Mpc away from the main body of the cluster. We also argue that the scatter of the SF main sequence could be dependent on the distance to the nearest neighboring galaxy.

  20. Determining the native/non-native status of newly discovered terrestrial and freshwater species in Antarctica - current knowledge, methodology and management action.

    PubMed

    Hughes, Kevin A; Convey, Peter

    2012-01-01

    Continental Antarctic terrestrial and freshwater environments currently have few established non-native species compared to the sub-Antarctic islands and other terrestrial ecosystems on Earth. This is due to a unique combination of factors including Antarctica's remoteness, harsh climate, physical geography and brief history of human activity. However, recent increases in national operator and tourism activities increase the risk of non-native propagules reaching Antarctica, while climate change may make successful establishment more likely. The frequency and probability of human-assisted transfer mechanisms appear to far outweigh those of natural propagule introductions by wind, water, birds and marine mammals. A dilemma for scientists and environmental managers, which is exacerbated by a poor baseline knowledge of Antarctic biodiversity, is how to determine the native/non-native status of a newly discovered species which could be (a) a previously undiscovered long-term native species, (b) a recent natural colonist or (c) a human-mediated introduction. A correct diagnosis is crucial as the Protocol on Environmental Protection to the Antarctic Treaty dictates dramatically different management responses depending on native/non-native status: native species and recent natural colonists should be protected and conserved, while non-native introductions should be eradicated or controlled. We review current knowledge on how available evidence should be used to differentiate between native and non-native species, and discuss and recommend issues that should be considered by scientists and managers upon discovery of a species apparently new to the Antarctic region.

  1. The environmental impacts on the star formation main sequence: An Hα study of the newly discovered rich cluster at z = 1.52

    SciTech Connect

    Koyama, Yusei; Kodama, Tadayuki; Tadaki, Ken-ichi; Hayashi, Masao; Tanaka, Ichi; Shimakawa, Rhythm

    2014-07-01

    We report the discovery of a strong over-density of galaxies in the field of a radio galaxy at z = 1.52 (4C 65.22) based on our broadband and narrow-band (Hα) photometry with the Subaru Telescope. We find that Hα emitters are located in the outskirts of the density peak (cluster core) dominated by passive red-sequence galaxies. This resembles the situation in lower-redshift clusters, suggesting that the newly discovered structure is a well-evolved rich galaxy cluster at z = 1.5. Our data suggest that the color-density and stellar mass-density relations are already in place at z ∼ 1.5, mostly driven by the passive red massive galaxies residing within r{sub c} ≲ 200 kpc from the cluster core. These environmental trends almost disappear when we consider only star-forming (SF) galaxies. We do not find SFR-density or SSFR-density relations amongst SF galaxies, and the location of the SF main sequence does not significantly change with environment. Nevertheless, we find a tentative hint that star-bursting galaxies (up-scattered objects from the main sequence) are preferentially located in a small group at ∼1 Mpc away from the main body of the cluster. We also argue that the scatter of the SF main sequence could be dependent on the distance to the nearest neighboring galaxy.

  2. Two key polymorphisms in a newly discovered allele of the Vitis vinifera TPS24 gene are responsible for the production of the rotundone precursor α-guaiene

    PubMed Central

    Drew, Damian Paul; Andersen, Trine Bundgaard; Sweetman, Crystal; Møller, Birger Lindberg; Ford, Christopher; Simonsen, Henrik Toft

    2016-01-01

    Rotundone was initially identified as a grape-derived compound responsible for the peppery aroma of Shiraz wine varieties. It has subsequently been found in black and white pepper and several other spices. Because of its potent aroma, the molecular basis for rotundone formation is of particular relevance to grape and wine scientists and industry. We have identified and functionally characterized in planta a sesquiterpene synthase, VvGuaS, from developing grape berries, and have demonstrated that it produces the precursor of rotundone, α-guaiene, as its main product. The VvGuaS enzyme is a novel allele of the sesquiterpene synthase gene, VvTPS24, which has previously been reported to encode VvPNSeInt, an enzyme that produces a variety of selinene-type sesquiterpenes. This newly discovered VvTPS24 allele encodes an enzyme 99.5% identical to VvPNSeInt, with the differences comprising just 6 out of the 561 amino acid residues. Molecular modelling of the enzymes revealed that two of these residues, T414 and V530, are located in the active site of VvGuaS within 4 Å of the binding-site of the substrate, farnesyl pyrophosphate. Mutation of these two residues of VvGuaS into the corresponding polymorphisms in VvPNSeInt results in a complete functional conversion of one enzyme into the other, while mutation of each residue individually produces an intermediate change in the product profile. We have therefore demonstrated that VvGuaS, an enzyme responsible for production of the rotundone precursor, α-guaiene, is encoded by a novel allele of the previously characterized grapevine gene VvTPS24 and that two specific polymorphisms are responsible for functional differences between VvTPS24 alleles. PMID:26590310

  3. Petrology, geochemistry and genesis of newly discovered Mesoproterozoic highly magnesian, calcite-rich kimberlites from Siddanpalli, Eastern Dharwar Craton, Southern India: products of subduction-related magmatic sources?

    NASA Astrophysics Data System (ADS)

    Chalapathi Rao, N. V.; Dongre, A.; Kamde, G.; Srivastava, Rajesh K.; Sridhar, M.; Kaminsky, F. V.

    2010-03-01

    The Siddanpalli kimberlites constitute a newly discovered cluster (SKC) of Mesoproterozoic (1090 Ma) dykes occurring in the granite-greenstone terrain of the Gadwal area in the Eastern Dharwar Craton (EDC), Southern India. They belong to coherent facies and contain serpentinized olivines (two generations), phlogopite, spinel, perovskite, ilmenite, apatite, carbonate and garnet xenocrysts. A peculiar feature of these kimberlites is the abundance of carbonate and limestone xenoliths of the eroded platformal Proterozoic (Purana) sedimentary cover of Kurnool/Bhima age. Chemically, the Siddanpalli dykes are the most magnesium-rich (up to 35 wt.% MgO) and silica-undersaturated (SiO2 < 35 wt.%) of all kimberlites described so far from the Eastern Dharwar Craton. The La/Yb ratio in the Siddanpalli kimberlites (64-105) is considerably lower than that in the other EDC kimberlites (108-145), primarily owing to their much higher HREE abundances. Since there is no evidence of any crustal contamination by granitic rocks we infer this to be a specific character of the magmatic source. A comparison of the REE geochemistry of the Siddanpalli kimberlites with petrogenetic models for southern African kimberlites suggests that they display involvement of a wide range in the degree of melting in their genesis. The different geochemical signatures of the SKC compared to the other known kimberlites in the EDC can be explained by a combination of factors involving: (i) higher degrees of partial melting; (ii) relatively shallower depths of derivation; (iii) possible involvement of subducted component in their mantle source region; and (iv) previous extraction of boninitic magmas from their geological domain.

  4. Antiproliferative and cytotoxic effects of newly discovered halogenated coral prostanoids from the Japanese stolonifer Clavularia viridis on human myeloid leukemia cells in culture.

    PubMed

    Honda, A; Mori, Y; Iguchi, K; Yamada, Y

    1987-10-01

    The antiproliferative and cytotoxic activities of newly discovered halogenated coral prostanoids (chlorovulone, bromovulone, and iodovulone) from the Japanese stolonifer Clavularia viridis and their related compounds were determined in HL-60 cells in culture. The order of antiproliferative and cytotoxic activities of naturally occurring marine prostanoids against HL-60 cells was chlorovulone I greater than bromovulone I = iodovulone I greater than clavulone I or II greater than prostaglandin A2. The IC50 (concentrations required to inhibit cell growth by 50%) value (0.03 microM (0.01 microgram/ml)) and cytotoxic effects (greater than 0.3 microM (0.1 microgram/ml)) of chlorovulone I were about 200 and 100 times stronger than those of prostaglandin A2, respectively, on the molar basis. From our data on the structure-activity relationship of the halogenated coral prostanoids and the related compounds, we elucidated that 1) the alkylidencyclopentenone structure in these prostanoids was essential for the antiproliferative and cytotoxic activities against HL-60 cells and the introduction of halogen function at C-10 position in the structure enhanced the activities (C1 = F greater than Br = I greater than H); 2) the stereospecificity of the 12-hydroxyl group in the chlorovulone molecule was not required for the activities; 3) the presence of dienone (C5-6 and C7-8) in the structure potentiated the activities. Bivariate DNA/bromodeoxyuridine analysis with a flow cytometer showed that chlorovulone I transiently arrested the cell cycle progression from G1 to S after 24-hr exposure to the nontoxic concentrations (0.03 and 0.09 microM) and caused the lasting blockade of leukemia cells in G1 at the cytotoxic concentration. These results suggest that these coral prostanoids and related compounds may be a promising antileukemic agent.

  5. Authigenic carbonates from newly discovered active cold seeps on the northwestern slope of the South China Sea: Constraints on fluid sources, formation environments, and seepage dynamics

    NASA Astrophysics Data System (ADS)

    Liang, Qianyong; Hu, Yu; Feng, Dong; Peckmann, Jörn; Chen, Linying; Yang, Shengxiong; Liang, Jinqiang; Tao, Jun; Chen, Duofu

    2017-06-01

    Authigenic carbonates recovered from two newly discovered active cold seeps on the northwestern slope of the South China Sea have been studied using petrography, mineralogy, stable carbon and oxygen isotopic, as well as trace element compositions, together with AMS 14C ages of shells of seep-dwelling bivalves to unravel fluid sources, formation conditions, and seepage dynamics. The two seeps (ROV1 and ROV2), referred to as 'Haima seeps' herein, are approximately 7 kilometers apart, and are typified by abundant carbonate rocks represented bycrusts and nodules. Aragonite and high-Mg calcite are the main carbonate minerals. Based on low δ13Ccarbonate values ranging from -43.0‰ to -27.5‰ (V-PDB) methane is apparently the predominant carbon source of seep carbonates. The corresponding δ18O values, varying from 2.5‰ to 5.8‰ (V-PDB), mostly are higher than calculated values representing precipitation in equilibrium with seawater (2.5‰ to 3.8‰), which probably reflects past destabilization of locally abundant gas hydrates. In addition, we found that carbonates with bivalve shells are generally aragonite-dominated, and bear no barium enrichment but uranium enrichments, reflecting shallow formation depths close to the seafloor. In contrast, carbonate crusts without bivalve shells and nodules contain more calcite, and are characterized by major molybdenum enrichment and different degrees of barium enrichment, agreeing with precipitation at greater depth under strictly anoxic conditions. AMS 14C ages suggest that a major episode of carbonate precipitation occurred between 6.1 ka and 5.1 ka BP at the Haima seeps, followed by a possibly subordinate episode from approximately 3.9 ka to 2.9 ka BP. The common occurrence of dead bivalves at both sites indicates that chemosynthesis-based communities flourished to a greater extent in the past, probably reflecting a decline of seepage activity in recent times. Overall, these results confirm that authigenic carbonates from

  6. CoRoT's view of newly discovered B-star pulsators: results for 358 candidate B pulsators from the initial run's exoplanet field data

    NASA Astrophysics Data System (ADS)

    Degroote, P.; Aerts, C.; Ollivier, M.; Miglio, A.; Debosscher, J.; Cuypers, J.; Briquet, M.; Montalbán, J.; Thoul, A.; Noels, A.; De Cat, P.; Balaguer-Núñez, L.; Maceroni, C.; Ribas, I.; Auvergne, M.; Baglin, A.; Deleuil, M.; Weiss, W. W.; Jorda, L.; Baudin, F.; Samadi, R.

    2009-10-01

    Context: We search for new variable B-type pulsators in the CoRoT data assembled primarily for planet detection, as part of CoRoT's additional programme. Aims: We aim to explore the properties of newly discovered B-type pulsators from the uninterrupted CoRoT space-based photometry and to compare them with known members of the β Cep and slowly pulsating B star (SPB) classes. Methods: We developed automated data analysis tools that include algorithms for jump correction, light-curve detrending, frequency detection, frequency combination search, and for frequency and period spacing searches. Results: Besides numerous new, classical, slowly pulsating B stars, we find evidence for a new class of low-amplitude B-type pulsators between the SPB and δ Sct instability strips, with a very broad range of frequencies and low amplitudes, as well as several slowly pulsating B stars with residual excess power at frequencies typically a factor three above their expected g-mode frequencies. Conclusions: The frequency data we obtained for numerous new B-type pulsators represent an appropriate starting point for further theoretical analyses of these stars, once their effective temperature, gravity, rotation velocity, and abundances will be derived spectroscopically in the framework of an ongoing FLAMES survey at the VLT. The CoRoT space mission was developed and is operated by the French space agency CNES, with the participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain. All frequency tables, including the identification of combination frequencies, are only available as online material. Frequency Tables are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/506/471 Bâtiment 121, 91405, Orsay Cedex, France. Postdoctoral Researcher, Fonds de la Recherche Scientifique - FNRS, Belgium. Postdoctoral Fellow of the Fund for Scientific Research

  7. Geochronology, petrology and Hf-S isotope geochemistry of the newly-discovered Xiarihamu magmatic Ni-Cu sulfide deposit in the Qinghai-Tibet plateau, western China

    NASA Astrophysics Data System (ADS)

    Li, Chusi; Zhang, Zhaowei; Li, Wenyuan; Wang, Yalei; Sun, Tao; Ripley, Edward M.

    2015-02-01

    This paper reports the first set of data for the newly-discovered Xiarihamu magmatic Ni-Cu sulfide deposit in the Eastern Kunlun Paleozoic arc terrane which is located in the northern part of the Qinghai-Tibet plateau. An on-going drilling campaign reveals ~ 100 million tons of sulfide mineralization with the average grade of 0.8 wt.% Ni and 0.1 wt.% Cu for the deposit. This makes the Xiarihamu deposit one of the 20 largest magmatic Ni-Cu sulfide deposits in the world and the largest ever found in arc settings. The deposit is hosted in a small ultramafic body intruding older gabbroic and metamorphic rocks. New zircon U-Pb isotope age data reveal that the ultramafic body (411.6 ± 2.4 Ma) is ~ 20 Ma younger than the host gabbroic intrusion (431.3 ± 2.1 Ma). The ultramafic body is composed predominantly of lherzolite and olivine websterite, with minor dunite, websterite and orthopyroxenite. Mineralization mainly occurs as sub-horizontal to gently dipping (< 30°) disseminated sulfide zones that are generally concordant with the lithological structure of the ultramafic intrusion. The lateral extension and thickness of individual mineralized zones are up to ~ 200 m and ~ 100 m, respectively. Sulfide mineral assemblages are composed of pyrrhotite, pentlandite and chalcopyrite. The Xiarihamu ultramafic rocks show light REE enrichments and pronounced negative Nb anomalies, plus significant Ca-depletion in olivine (< 700 ppm Ca), which are characteristic of many arc basalts in the world. Olivine crystals in the Xiarihamu ultramafic rocks have relatively primitive compositions, with Fo contents up to 90 mol%, close to the mantle value. The contrasting Ni contents of olivine crystals with similar Fo contents from different sulfide-mineralized zones in a single drill core indicate that at least two pulses of sulfide-laden magma with different Ni compositions were involved in the development of the deposit. Estimated parental magma for the Xiarihamu lherzolites contains 52

  8. We present 'Black Holes Make Stars which Explains the Mystery of the Newly Discovered Phoenix Galaxy while Dark Matter in the Universe is described in our Explanation.'

    NASA Astrophysics Data System (ADS)

    Cimorelli, Salvatore; Samuels, Charles

    2014-07-01

    We present an entirely new concept for 'How the universe and its contents might have formed.' We contend the Big Bang (BB) resulted from one (or two) Black Hole(s) (BH) bursting (or colliding), producing an almost infinite number of particles of varying sizes, from the smallest elementary particle to particles large enough to contain the mass of a galaxy. The accepted prevailing theory for stellar evolution is 'sufficiently massive stars are reduced to BH upon their ultimate demise.' We consider larger types of BH originating from the original BB, which are subsequently expanded and modified enough to start significant radiation and burst, which resulting particle eventually result into a Galaxy; and smaller BH which become stars and planets. We theorize the universe was made by a massive BH which had enough mass to produce the contents of our universe. We define and categorize BH by their mass and the spaces which they inhabit. We describe mechanisms for their formation and mechanisms of BH collisions and bursts, inside the universe, linked to formations of galaxies, stars, planets and moons. Our concept could explain the mystery of the newly discovered Phoenix Galaxy, which produces 740 Stars per year, an order of magnitude above expected. We propose that a category-1 (c-1) BH formed the universe, by generating c-2 BH which form galaxies, c-3 BH which form stars, and c-4 BH which form planets and moons. Each sequential category of BH is less dense, and is more expanded and modified; and links the formation of the universe to present day activities and processes observed on earth, especially leading to the formation of the elements on earth. We offer three mechanisms (a, b, & c) for stellar origin, formation and evolution. 'a' is the accepted 'accretion and gravitation process.' 'b' is 'as a star originates as an expanded, modified BH with none or little help from accretion, begins to radiate; and continues to grow into a star. 'c' is a mechanism in which a star

  9. Noble Gas geochemistry of the newly discovered hydrothermal fields in the Gulf of California: preliminary He-isotope ratios from the Alarcon Rise and Pescadero basin vent sites

    NASA Astrophysics Data System (ADS)

    Spelz, R. M.; Lupton, J. E.; Evans, L. J.; Zierenberg, R. A.; Clague, D. A.; Neumann, F.; Paduan, J. B.

    2015-12-01

    Numerous submarine deep-sea hydrothermal vents related to volcanic activity of the East Pacific Rise (EPR) are situated along the Pacific margins of Mexico. Until recently, active hydrothermal venting was unknown between the Guaymas Basin and 21°N on the EPR. MBARI's recent oceanographic surveys have added 7 new active vent sites. In this study, we aimed to sample the high-temperature hydrothermal fluids emanating from two distinct vent sites, named Meyibo and Auka, located in the Alarcon Rise and Pescadero Basin, respectively. Mantle-derived He have long been identified in hydrothermal fluid releases. The presence of He in aqueous fluids with 3He/4He ratios greater than in-situ production values (~0.05 RA, where RA = air He or 1.4 x 10-6) indicates the presence of mantle-derived melts. Preliminary analyses of He-isotope ratios derived from the newly discovered Meyibo and Auka hydrothermal fields show high 3He/4He ratios (~8RA), typical of MORB's. Auka vent field, characterized by chimneys composed of light carbonate minerals and oil-like hydrocarbons, and temperatures between 250-290oC, show average values of ~7.87RA. In contrast, the black-smokers at the Meyibo field, composed of dark sulfide minerals and temperatures over 350oC, yielded a higher He ratio of ~8.24RA. Recently, it has become clear that regional maximum mantle He values correlate with the velocity structure in the mantle, therefore, He has the potential to map regions of the underlying mantle that are undergoing partial melting. Seismic records could then be compared with the geochemical He ratio signal and supply information regarding tectonics and other processes involved in the generation of these gases. The data presented here will be completing a totally new inventory of He results from hydrothermal vents in the EPR and fault-termination basins distributed along the P-NA plate boundary in the Gulf of California. The results will be further coupled with the analysis of other geochemical

  10. Black Holes Make Stars, which explains the Mystery of the Newly Discovered Phoenix Galaxy (while Dark Matter is described in the explanation)

    NASA Astrophysics Data System (ADS)

    Cimorelli, Salvatore A.; Samuels, Chares

    2013-07-01

    A prevailing theory is stars change their energy field and are reduced to Black Holes (BH). Consider there are as many types of BH as there are of stars, and a greatly expanded modified Black Hole (from the original 'Big Bang'), can become a Star. We theorize that something is not made of nothing; and the universe was created by a massive Black Hole in c-1 space, which had enough mass to produce what is contained in our universe, today. We categorized BH, by their mass. Our concept could explain 'the Mystery of the Newly Discovered 'PHOENIX GALAXY' and presents a new theory of what forms of dark matter could exist. We define and categorize BH and the space they inhabit. These are linked to the formation of galaxies, stars, planets and planetary processes. Space itself is categorized as to its purpose and properties as it relates to the various categories of BH and processes ongoing within their space(s). We propose a category-1 (c-1) BH formed the universe, by generating billions of catagory-2 (c-2) BH in c-2 space inside the universe, 10% of which formed galaxies and 90% remain as dark matter in the form of c-2 and c-3 BH which are still evolving. C-2 BH can burst and form a galaxy, containing c-3 space, filled with c-3 and c-4 BH. C-3 BH are significantly more modified and expanded than c-2 BH and are formed from burst c-2 BH on their own or by colliding with another c-2 BH and bursting to form gas and dust clouds inside the galaxy, peppered with c-3 and c-4 BH which eventually are seen as new stars forming in the dust clouds (described later). We envision three mechanisms (a,b,&c) for stellar origin, formation and evolution . The first type "a" is well known (accepted); whereas, the other two "b&c" are new and will be presented. This explains how some super-cluster complexes can occur in 13.4 billion years rather than over 40 billion years.

  11. Origin of Late Mesozoic granitoids in the newly discovered Zha-Shan porphyry Cu district, South Qinling, central China, and implications for regional metallogeny

    NASA Astrophysics Data System (ADS)

    Xie, Guiqing; Mao, Jingwen; Wang, Ruiting; Ren, Tao; Li, Jianbi; Da, Junzhi

    2015-05-01

    The newly discovered porphyry Cu deposits in the South Qinling Belt (SQB) have not been well researched as compared with the large porphyry Mo province in the southern North China Block (S-NCB), and the origin of granitoids associated with porphyry Cu mineralization in the Zha-Shan district, SQB is poorly constrained. Here, we present detailed zircon U-Pb geochronological, whole rock elemental and Sr-Nd isotopic data for important Late Mesozoic granitoid stocks associated with porphyry Cu deposits in the Zha-Shan district; these data are used to constrain the age and the source of magmas that formed these granitoids, and implication of regional metallogeny. The new zircon LA-ICPMS U-Pb ages presented here indicate that the granitoids related to porphyry Cu system at Chigou, Beishagou, Shuangyuangou and Yuanjiagou developed at 148-144 Ma, 144 Ma, 145-144 Ma and 146 Ma, respectively. These rocks are high-K calc-alkaline I-type granitoids, which are enriched in large ion lithophile elements (e.g., Th, U, and Pb) and light rare earth elements, are depleted in Nb, Ta and Ti, characterizing by wide variations in initial εNd(t) (-3.8 to -9.5), and moderate radiogenic Sr isotopes ((87Sr/86Sr)i = 0.7046 to 0.7093). These features indicate that the magmas that formed the granitoids related to porphyry Cu system in the Zha-Shan district formed as a result of variable degrees of mixing between crustal and metasomatic lithospheric mantle. The new zircon LA-ICPMS U-Pb ages in this study, combined with previous published data, suggest that regional-scale Late Jurassic to Early Cretaceous granitoid stocks, and associated porphyry Cu and Mo systems in both the S-NCB and SQB formed almost contemporaneously, with 147-139 Ma porphyry Mo deposits in the S-NCB and 148-145 Ma porphyry Cu deposits in the SQB. The Cu-related intrusions contained a greater contribution of lithospheric mantle component than the Mo-related intrusions in the East Qinling Orogeny.

  12. Black Holes Make Stars which explains the Mystery of the Newly Discovered PHOENIX GALAXY, while Dark Matter is described in the explanation

    NASA Astrophysics Data System (ADS)

    Cimorelli, S. A.

    2013-12-01

    A prevailing theory is some Stars change their energy field and are reduced to Black Holes (BHs). Consider an expanded modified Black Hole from the original Big Bang which might have been a massive Black Hole can become a Galaxy and or a Star. We theorize something is not made of nothing; and the universe was created by a massive Black Hole which had enough mass to produce what is contained in our universe today. We categorized BH by their mass. Our concept could explain the Mystery of the Newly Discovered PHOENIX GALAXY. We define and categorize black holes and the space they inhabit. We describe mechanisms for their formation and mechanisms of black hole collisions and bursts, inside of the universe. These are linked to the formation of galaxies, stars, planets and planetary processes. Insight is gained regarding the formation and evolution of galaxies and the matter contained therein. Space itself is categorized as to its purpose and properties as it relates to the categories of black holes and processes ongoing within the space in which the processes occur. We suggest a category-1 (c-1) black hole burst by collision or on it's own and formed the universe by generating great numbers of c-2 BHs inside the universe, in c-2 space, which become galaxies and which is the start of the universe, 10% of which formed galaxies and 90% remain as dark matter as c-2 and c-3 BHs which are still evolving. C-2 BHs can burst to form a galaxy, containing c-3 space, filled with c-3 and c-4 BHs. C-3 BHs are significantly more modified and expanded than c-2 BHs and are formed from burst c-2 BHs to form gas and dust clouds peppered with the c-3 BHs Remnants from the burst c-2 BH include sizes from minute particles which contribute to the formation of massive gas and dust clouds; to 10 to 20 solar masses that form large stars; and others, tiny stars which eventually become planets and moons. These gas and dust clouds are peppered with c-4 BHs which eventually are seen as new stars

  13. Using internet images to gather distributional data for a newly discovered Caloptilia species (Lepidoptera: Gracillariidae) specializing on Chinese tallow in North America

    USDA-ARS?s Scientific Manuscript database

    Chinese tallow tree (Triadica sebifera (L.), Euphorbiaceae) is a noxious and highly invasive species that was deliberately introduced to GA in 1772. In early 2009, an unfamiliar caterpillar was independently discovered feeding on T. sebifera trees in Gainesville, FL and Slidell, LA. Adult moths were...

  14. Home range and use of diurnal shelters by the Etendeka round-eared sengi, a newly discovered Namibian endemic desert mammal

    PubMed Central

    Dumbacher, John P.

    2015-01-01

    To understand habitat use by the newly described Etendeka round-eared sengi (Macroscelides micus) in northwestern Namibia, we radio-tracked five individuals for nearly a month. Home ranges (100% convex polygons) in the rocky desert habitat were remarkably large (mean 14.9 ha) when compared to sengi species in more mesic habitats (<1.5 ha). The activity pattern of M. micus was strictly nocturnal, which contrasts to the normal diurnal or crepuscular activity of other sengis. The day shelters of M. micus were under single rocks and they likely were occupied by single sengis. One tagged sengi used 22 different day shelters during the study. On average, only 7% of the day shelters were used more than once by the five tagged sengis. The shelters were also unusual for a small mammal in that they were unmodified in terms of excavation or nesting material. Shelter entrances were significantly oriented to face south by south west (average 193°), away from the angle of the prevailing midday sun. This suggests that solar radiation is probably an important aspect of M. micus thermal ecology, similar to other sengis. Compared to published data on other sengis, M. micus generally conforms to the unique sengi adaptive syndrome, but with modifications related to its hyper-arid habitat. PMID:26557433

  15. Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.

    PubMed

    Marshall, Jamie L; Chou, Eric; Oh, Jennifer; Kwok, Allan; Burkin, Dean J; Crosbie-Watson, Rachelle H

    2012-10-15

    Sarcospan (SSPN) is a core component of the major adhesion complexes in skeletal muscle, the dystrophin- and utrophin (Utr)-glycoprotein complexes (DGC and UGC). We performed a rigorous analysis of SSPN-null mice and discovered that loss of SSPN decreased DGC and UGC abundance, leading to impaired laminin-binding activity and susceptibility to eccentric contraction-induced injury in skeletal muscle. We show that loss of SSPN increased levels of α7β1 integrin. To genetically test whether integrin compensates for the loss of DGC and UGC function in SSPN-nulls, we generated mice lacking both SSPN and α7 integrin (DKO, double knockout). Muscle regeneration, sarcolemma integrity and fibrosis were exacerbated in DKO mice and were remarkably similar to muscle from Duchenne muscular dystrophy (DMD) patients, suggesting that secondary loss of integrin contributes significantly to pathogenesis. Expression of the DGC and UGC, laminin binding and Akt signaling were negatively impacted in DKO muscle, resulting in severely diminished specific force properties. We demonstrate that SSPN is a necessary component of dystrophin and Utr function and that SSPN modulation of integrin signaling is required for extracellular matrix attachment and muscle force development.

  16. DDT_yamamura_1: Herschel photometry of WISE J180956.27-330500.2; a newly discovered AGB star undergoing episodic mass ejection

    NASA Astrophysics Data System (ADS)

    Yamamura, I.

    2012-05-01

    We propose to carry out imaging photometry of WISE J180956.27-330500.2 (hereafter WISE J1810) using PACS (at 70, 110, 160 micron) and SPIRE (at 250, 350, 500 micron) in order to obtain the latest far-IR and sub-mm fluxes of the object and constrain the nature of its mass-loss history. WISE J1810 was discovered very recently by us (Gandhi et al. 2012) as an object with a peculiar 2MASS--WISE spectral energy distribution (SED). We propose that the object is an asymptotic giant branch (AGB) star presently experiencing an episodic mass-loss event following a thermal pulse. If this is the case, it is the first opportunity of real-time observation of AGB mass ejection at thermal pulse. The infrared SED of this object is rapidly evolving over the past 15 years and updated observations over a broad wavelength range are essential. Herschel is the only available facility with the capability of high-sensitivity, high-spatial resolution observations at far-infrared and sub-mm wavelengths, and can provide indispensable information of the rapidly expanding dust shell of this object. The unique nature of this source, its recent bright appearance and rapid evolution prompt us to request a DDT observation while Herschel is still operating. The requested observing time is 1414 sec, which is the minimum operation time for the observing modes that will be used.

  17. Newly Discovered Paleocene and Eocene Rocks near Fairfield, California, and Correlation with Rocks in Vaca Valley and the So-Called Martinez Formation or Stage

    USGS Publications Warehouse

    Brabb, Earl E.; Ristau, Donn; Bukry, David; McDougall, Kristin; Almgren, Alvin A.; Saul, LouElla; Sanfilippo, Annika

    2008-01-01

    Discovery of a 3-foot thick sandstone bed with abundant Turritellid gastropods of late Paleocene age about 4 miles northeast of Fairfield and on the southwest flank of Cement Hill, Solano County provides an opportunity to reevaluate the relationships of lower Tertiary formations in this part of California. Cement Hill is named for travertine deposits in and on top of sandstone of Late Cretaceous age. In this report, the current study area where the Paleocene fossils were recently discovered is referred to as lower Cement Hill and is located in section 7 of the U.S. Geological Survey Fairfield North 7.5-minute quadrangle, Township 5 North, Range 1 West. Lower Cement Hill is about 23 miles north of the so-called Martinez 'formation' or stage area (Weaver and others, 1941) of late Paleocene age near Martinez. The Martinez 'formation' and stage have played a significant role in the development of early Tertiary stratigraphy in this part of California. The discovery of correlative rocks at Cement Hill was unsuspected and may be helpful in defining the extent of this so-called formation or stage. Coccolith identification and correlations are by David Bukry, foraminifer identifications and correlations by Alvin Almgren and Kristin McDougall, gastropod identification and correlation by LouElla Saul, and Radiolaria identifications and correlations are by Annika Sanfilippo.

  18. SDSS J013127.34–032100.1: A NEWLY DISCOVERED RADIO-LOUD QUASAR AT z = 5.18 WITH EXTREMELY HIGH LUMINOSITY

    SciTech Connect

    Yi, Wei-Min; Bai, Jin-Ming; Zhang, Ju-jia; Wang, Fang; Wang, Jian-Guo; Fan, Yu-Feng; Chang, Liang; Wang, Chuan-Jun; Lun, Bao-Li; Wang, Feige; Wu, Xue-Bing; Yang, Jinyi; Ho, Luis C.; Zuo, Wenwen; Yang, Qian; Ai, Yanli; Fan, Xiaohui; Brandt, William N.; Kim, Minjin; Wang, Ran; and others

    2014-11-10

    Very few of the z > 5 quasars discovered to date have been radio-loud, with radio-to-optical flux ratios (radio-loudness parameters) higher than 10. Here we report the discovery of an optically luminous radio-loud quasar, SDSS J013127.34–032100.1 (J0131–0321 in short), at z = 5.18 ± 0.01 using the Lijiang 2.4 m and Magellan telescopes. J0131–0321 has a spectral energy distribution consistent with that of radio-loud quasars. With an i-band magnitude of 18.47 and a radio flux density of 33 mJy, its radio-loudness parameter is ∼100. The optical and near-infrared spectra taken by Magellan enable us to estimate its bolometric luminosity to be L {sub bol} ∼ 1.1 × 10{sup 48} erg s{sup –1}, approximately 4.5 times greater than that of the most distant quasar known to date. The black hole mass of J0131–0321 is estimated to be 2.7 × 10{sup 9} M {sub ☉}, with an uncertainty up to 0.4 dex. Detailed physical properties of this high-redshift, radio-loud, potentially super-Eddington quasar can be probed in the future with more dedicated and intensive follow-up observations using multi-wavelength facilities.

  19. SDSS J013127.34-032100.1: A Newly Discovered Radio-loud Quasar at z = 5.18 with Extremely High Luminosity

    NASA Astrophysics Data System (ADS)

    Yi, Wei-Min; Wang, Feige; Wu, Xue-Bing; Yang, Jinyi; Bai, Jin-Ming; Fan, Xiaohui; Brandt, William N.; Ho, Luis C.; Zuo, Wenwen; Kim, Minjin; Wang, Ran; Yang, Qian; Zhang, Ju-jia; Wang, Fang; Wang, Jian-Guo; Ai, Yanli; Fan, Yu-Feng; Chang, Liang; Wang, Chuan-Jun; Lun, Bao-Li; Xin, Yu-Xin

    2014-11-01

    Very few of the z > 5 quasars discovered to date have been radio-loud, with radio-to-optical flux ratios (radio-loudness parameters) higher than 10. Here we report the discovery of an optically luminous radio-loud quasar, SDSS J013127.34-032100.1 (J0131-0321 in short), at z = 5.18 ± 0.01 using the Lijiang 2.4 m and Magellan telescopes. J0131-0321 has a spectral energy distribution consistent with that of radio-loud quasars. With an i-band magnitude of 18.47 and a radio flux density of 33 mJy, its radio-loudness parameter is ~100. The optical and near-infrared spectra taken by Magellan enable us to estimate its bolometric luminosity to be L bol ~ 1.1 × 1048 erg s-1, approximately 4.5 times greater than that of the most distant quasar known to date. The black hole mass of J0131-0321 is estimated to be 2.7 × 109 M ⊙, with an uncertainty up to 0.4 dex. Detailed physical properties of this high-redshift, radio-loud, potentially super-Eddington quasar can be probed in the future with more dedicated and intensive follow-up observations using multi-wavelength facilities.

  20. Carboniferous and Permian evolutionary records for the Paleo-Tethys Ocean constrained by newly discovered Xiangtaohu ophiolites from central Qiangtang, central Tibet

    NASA Astrophysics Data System (ADS)

    Zhang, Xiu-Zheng; Dong, Yong-Sheng; Wang, Qiang; Dan, Wei; Zhang, Chunfu; Deng, Ming-Rong; Xu, Wang; Xia, Xiao-Ping; Zeng, Ji-Peng; Liang, He

    2016-07-01

    Reconstructing the evolutionary history of the Paleo-Tethys Ocean remains at the center of debates over the linkage between Gondwana dispersion and Asian accretion. Identifying the remnants of oceanic lithosphere (ophiolites) has very important implications for identifying suture zones, unveiling the evolutionary history of fossil oceans, and reconstructing the amalgamation history between different blocks. Here we report newly documented ophiolite suites from the Longmu Co-Shuanghu Suture zone (LSSZ) in the Xiangtaohu area, central Qiangtang block, Tibet. Detailed geological investigations and zircon U-Pb dating reveal that the Xiangtaohu ophiolites are composed of a suite of Permian (281-275 Ma) ophiolites with a nearly complete Penrose sequence and a suite of Early Carboniferous (circa 350 Ma) ophiolite remnants containing only part of the lower oceanic crust. Geochemical and Sr-Nd-O isotopic data show that the Permian and Carboniferous ophiolites in this study were derived from an N-mid-ocean ridge basalts-like mantle source with varied suprasubduction-zone (SSZ) signatures and were characterized by crystallization sequences from wet magmas, suggesting typical SSZ-affinity ophiolites. Permian and Carboniferous SSZ ophiolites in the central Qiangtang provide robust evidence for the existence and evolution of an ancient ocean basin. Combining with previous studies on high-pressure metamorphic rocks and pelagic radiolarian cherts, and with tectonostratigraphic and paleontological data, we support the LSSZ as representing the main suture of the Paleo-Tethys Ocean which probably existed and evolved from Devonian to Triassic. The opening and demise of the Paleo-Tethys Ocean dominated the formation of the major framework for the East and/or Southeast Asia.

  1. The Eugen Seibold coral mounds offshore western Morocco: oceanographic and bathymetric boundary conditions of a newly discovered cold-water coral province

    NASA Astrophysics Data System (ADS)

    Glogowski, Silke; Dullo, Wolf-Christian; Feldens, Peter; Liebetrau, Volker; von Reumont, Jonas; Hühnerbach, Veit; Krastel, Sebastian; Wynn, Russell B.; Flögel, Sascha

    2015-08-01

    This study reports a new cold-water coral (CWC) province covering ~410 km2 off western Morocco (ca. 31°N) ~40 nautical miles north of the Agadir Canyon system between 678 and 863 m water depth, here named the Eugen Seibold coral mounds. Individual mounds are up to 12 m high with slope angles varying between 3° and 12°. Hydroacoustic data revealed mound axes lengths of 80 to 240 m. Slope angle, mound height, and density of mounds decrease with increasing water depth. The deepest mounds are composed of dead and fragmented Lophelia pertusa branches. Living CWCs, mainly L. pertusa, were sampled with box cores between 678 and 719 m water depth. Conductivity-temperature-depth (CTD) measurements revealed living CWC colonies to occur within the deeper part of the North Atlantic Central Water (NACW; conservative temperature Θ of 9.78-9.94 °C, absolute salinity SA of ca. 35.632 g/kg, and seawater density σΘ of 27.31-27.33 kg/m3). Comparable CWC reefs off Mauritania (17°N-18°N) and on the Renard Ridge (35°N) in the Gulf of Cadiz, the latter consisting only of a dead CWC fabric, are also located in the deeper layer of the NACW slightly above the Mediterranean Outflow Water. The new CWC province, with its thin cover of living corals and much larger accumulations of dead thickets and fragmented coral rubble, was successfully discovered by CTD reconnaissance applying seawater density as a potential indicator of CWC occurrences, followed by hydroacoustic mapping. U-Th isotope systematics for macroscopically altered buried Lophelia material (25 cm sediment depth) yielded absolute ages dating back to the late Holocene at least.

  2. The Dangeard and Explorer canyons, South Western Approaches UK: Geology, sedimentology and newly discovered cold-water coral mini-mounds

    NASA Astrophysics Data System (ADS)

    Stewart, Heather A.; Davies, Jaime S.; Guinan, Janine; Howell, Kerry L.

    2014-06-01

    The Celtic Margin is a complex area in terms of sedimentary dynamics and evolution, with a number of submarine canyons dissecting the continental slope and outer continental shelf. The complex terrain and diverse range of sea-bed sediments play a part in submarine canyons being described as areas of high habitat heterogeneity. This study has concentrated on the heads of two canyons: Dangeard (also known as Dangaard) and Explorer (first named here) located in UK territorial waters, in water depths between 138 and 1165 m. Multibeam echosounder, 2D reflection seismic and photographic ground-truthing data have been combined to map the sea-bed geomorphology, sedimentary features and canyon megafauna of these canyons. In addition, two previously unknown provinces of cold-water coral (CWC) mini-mounds were discovered on the interfluves of the Dangeard and Explorer canyons. The study area comprises a dendritic network of gullies feeding into the canyon thalwegs. Amphitheatre rims, where slope angles are commonly in excess of 20°, occur along the margins and heads of both canyons and are interpreted as drainage basins indicative of retrogressive mass-wasting in a shelfward direction. The CWC mini-mounds occur in water depths between 250 m and 410 m, with more than 400 mounds identified. They are up to 3 m in height and 50-150 m in diameter with no sub-surface expression, suggesting these mounds are, in geological terms, relatively young and possibly Holocene in age. Biological analyses revealed that the mounds form a habitat for ophiuroids and Munida associated with Lophelia pertusa coral rubble, suggesting these mini-mounds are not present-day living features.

  3. Visual Observations and Geologic Settings of the Newly-Discovered Black Smoker Vent Sites Across the Galapagos Ridge-Hotspot Intersection

    NASA Astrophysics Data System (ADS)

    Anderson, P.; Haymon, R.; MacDonald, K.; White, S.

    2006-12-01

    Nearly one-fifth of the global mid-ocean ridge is hotspot-affected, yet very little is known about how hotspots affect quantity and distribution of high-temperature hydrothermal vents along the ridge. During the 2005-06 GalAPAGoS expedition, acoustic and plume sensor surveys were conducted across the Galapagos ridge- hotspot intersection, lon. 94.5ºW- lon. 89.5ºW, to map fine scale geologic features and locate hydrothermal plumes emanating from the ridge crest. Where significant plumes were detected, the Medea fiber-optic camera sled was used successfully to find and image high-temperature vents on the seafloor. With Medea we discovered and imaged the first active and recently extinct black smokers known along the entire Galapagos Spreading Center (GSC), and documented the geologic setting of these vents. The Medea survey imaged numerous inactive vents as well as 3 active high-temperature vent fields along the ridge at 94º 04.5'W (Navidad Site), 91º56.2'W (Iguanas Site) and 91º54.3'W (Pinguinos Site). Two recently extinct vent fields also were identified at 91º23.4'-23.7'W and 91º13.8'W. All of the high-temperature vent sites that we identified along the GSC are found above relatively shallow AMC reflectors and are located in the middle 20% of ridge segments. Without exception the vent sites are located along fissures atop constructional axial volcanic ridges (AVR's) composed of relatively young pillow basalts. In some cases, the vents were associated with collapses adjacent to the fissures. The fissures appear to be eruptive sources of the pillow lavas comprising the AVR's. Video images of the chimneys show mature, cylindrical structures, up to 14m high; little diffuse flow; few animals; and some worm casts and dead clam shells, suggesting prior habitation. We conclude that distribution of the vents is controlled by magmatic processes, (i.e., by locations of shallow AMC magma reservoirs and eruptive fissures above dike intrusions), and that there is

  4. Newly discovered population of Aedes japonicus japonicus (Diptera: Culicidae) in Upper Bavaria, Germany, and Salzburg, Austria, is closely related to the Austrian/Slovenian bush mosquito population.

    PubMed

    Zielke, Dorothee E; Walther, Doreen; Kampen, Helge

    2016-03-21

    The German mosquito surveillance instrument 'Mueckenatlas' requests the general public to collect and submit mosquito specimens. Among these, increasing numbers of individuals of invasive species have been registered. Specimens of the Asian bush mosquito Aedes japonicus japonicus submitted from German Upper Bavaria, where this species had not previously been recorded, triggered regional monitoring in mid-2015. The search for Ae. j. japonicus breeding sites and developmental stages concentrated on cemeteries in the municipality of origin of the submitted specimens and, subsequently, in the whole region. A virtual grid consisting of 10 × 10 km(2) cells in which up to three cemeteries were checked, was laid over the region. A cell was considered positive as soon as Ae. j. japonicus larvae were detected, and regarded negative when no larvae could be found in any of the cemeteries inspected. All cells surrounding a positive cell were screened accordingly. A subset of collected Aedes j. japonicus specimens was subjected to microsatellite and nad4 sequence analyses, and obtained data were compared to individuals from previously discovered European populations. Based on the grid cells, an area of approximately 900 km(2) was populated by Ae. j. japonicus in Upper Bavaria and neighbouring Austria. Genetic analyses of microsatellites and nad4 gene sequences generated one genotype out of two previously described for Europe and three haplotypes, one of which had previously been found in Europe only in Ae. j. japonicus samples from a population in East Austria and Slovenia. The genetic analysis suggests the new population is closely related to the Austrian/Slovenian population. As Ae. j. japonicus is well adapted to temperate climates, it has a strong tendency to expand and to colonise new territories in Central Europe, which is facilitated by human-mediated, passive transportation. The new population in Upper Bavaria/Austria is the seventh separate population described in

  5. Newly Discovered Hydrothermal Plumes Along the Furious Fifties, South East Indian Ridge (SEIR; 128°E-140°E)

    NASA Astrophysics Data System (ADS)

    Boulart, C.; Chavagnac, V.; Briais, A.; Revillon, S.; Donval, J. P.; Guyader, V.

    2015-12-01

    We report on the first evidence for hydrothermal activity along the intermediate-spreading South-East Indian Ridge (SEIR) between Australia and Antarctica (128°E-140°E), discovered during the STORM cruise of R/V L'Atalante. This section of the SEIR is located east of the low-magma Australian-Antarctic Discordance (AAD), where the ridge has the morphology of a slow-spreading mid-ocean ridge despite its intermediate spreading rate of 75 mm/yr. The axial depth decreases eastward, reflecting an eastward increase in magma budget.Using in-situ geochemical tracers based on optical backscatter, temperature, redox potential sensor and in situ mass spectrometer (ISMS) anomalies, we establish the existence of several distinct hydrothermal plumes within the water column along the 500 nautical miles ridge section. At one site, the combination of near-bottom temperature anomalies of 0.1°C together with strong dissolved methane and dissolved carbon dioxide anomalies revealed by the ISMS provides the precise location of an active vent in the Deep Southern Indian Ocean off Tasmania. Hydrothermal venting along the 128°E-140°E section of the SEIR appears to be significant, an observation consistent with the global link between spreading rate and plume occurrence (Baker and German, 2004). Moreover, the plume incidence increases westward and, in the eastern part, hydrothermal venting seems to be less significant, suggesting a possible influence of the high magma budget, as observed in mid-ocean ridge sections affected by hotspots. Future investigation will focus on the direct identification of venting sources and the study of hydrothermal circulation within the specific settings of the AAD. The observation of new venting sites at the frontier between Pacific and Indian Oceans may also provide new insights on the biogeography (diversity and distribution) of hydrothermal fauna. Baker, E. T., and C. R. German (2004), On the global distribution of hydrothermal vent fields, in Mid

  6. Intense gas bubble emissions in the Kerch seep area - A newly discovered high-flux seep site in the Black Sea

    NASA Astrophysics Data System (ADS)

    Römer, M.; Sahling, H.; Pape, T.; Bahr, A.; Feseker, T.; Wintersteller, P.; Bohrmann, G.

    2012-04-01

    More than 500 bubble-induced hydroacoustic anomalies (flares) were found in the water column above the seafloor in the study area comprising about 430 km2 at the Don-Kuban paleo-fan (Eastern Black Sea) by using ship mounted single beam and multibeam echosounders. Almost all flares originated from the seafloor above the gas hydrate stability zone (GHSZ), which in that region is located below ~700 m water depth. This observation confirms the sealing mechanism of gas hydrate, which impedes migration of free gas through the GHSZ and subsequent bubble emission from the seafloor. However, an intense seep site, called the "Kerch seep area" was discovered as an exception at 890 m water depth well within the GHSZ. In situ temperature measurements in shallow sediments indicate locally elevated temperatures probably caused by enhanced upward fluid flow. The base of the GHSZ in this region is generally situated at about 150 m below the seafloor. However, the local thermal anomalies result in a thinning of the gas hydrate occurrence zone to only a few meters below the seafloor and allow free gas to reach the seafloor. At sites where gas migrated into near-surface deposits, shallow gas hydrate deposits evolved and up-doming of overlying sediments led to the formation of mounds rising several meters from the surrounding seafloor. Further gas bubbles ascending from greater depth are accumulated below the gas hydrate layer at the base of the mound structures and migrate horizontally to their rims. At the mound edges gas bubbles either might form fresh gas hydrates and increase the extent of the mound structures by pushing up overlying sediments or escape at several sites into the water column. Two mounds were mapped in ultra-high resolution during dives with the autonomous underwater vehicle 'AUV MARUM SEAL 5000'. Several individual flares were detected in the Kerch seep area using hydroacoustic systems. Repeated surveys in that area conducted during three cruises within four years

  7. New Apollo asteroid discovered

    NASA Astrophysics Data System (ADS)

    Bell, Peter M.

    A new asteroid that periodically crosses the earth's orbit was recently discovered when two components of a rare split comet were photographed. The asteroid has been made a possible candidate for an asteroid rendezvous mission under study at Jet Propulsion Laboratory. The newly discovered body, 1982 DB, is a member of a group of earth-orbit-crossing objects called Apollo asteroids. They are maverick asteroids in unique orbits outside the main asteroid belt between Mars and Jupiter.

  8. Fuel Characterization of Newly Discovered Nigerian Coals

    NASA Astrophysics Data System (ADS)

    Bevan Nyakuma, Bemgba; Oladokun, Olagoke; Jauro, Aliyu; Damian Nyakuma, Denen

    2017-07-01

    This study seeks to characterize and highlight the fuel properties, rank, and classification of coals from Ihioma (IHM) and Ogboligbo (OGB) in Imo and Kogi states of Nigeria, respectively. The fuel properties were examined based on ultimate, proximate, and bomb calorific analyses. The results indicated that IHM coal contains comparatively higher C and H but lower O, N, and S content than OGB. In addition, the nitrogen (N) and sulphur (S) content for both coal samples were above 0.7 wt.% and 1.5 wt.%, respectively, which indicates high potential for pollutant emissions. Furthermore, the coal proximate properties were below 5 wt.% for Moisture; Volatiles (70 wt.%); Fixed Carbon (45 wt.%) and Ash (2.5 wt.%) on average. IHM coal has an HHV of 19.40 MJ/kg whereas OGB is 15.55 MJ/kg. This is due to the low carbon (C), hydrogen (H) and high oxygen (O) content in OGB whereas IHM contains higher VM and HHV. Furthermore, OGB presents better handling, storage, and transport potential. Furthermore, OGB has a higher fuel ratio and value index due to lower moisture, ash content, and volatiles. Based on the ASTM D388 standard, the coals were classified as Lignite (Brown) Low-Rank Coals (LRCs) with potential for energy recovery.

  9. Emerging biogeography of the newly discovered Zetaproteobacteria

    NASA Astrophysics Data System (ADS)

    McAllister, S.; Davis, R.; Emerson, D.; Moyer, C. L.

    2009-12-01

    The Zetaproteobacteria represent a novel candidatus class of Proteobacteria found predominantly at sites of microbially mediated iron oxidation in marine environments. The chemoautotrophic, neutrophilic Fe-oxidizing representative isolate for this novel class, Mariprofundus ferrooxydans, was isolated from Fe-oxide encrusted microbial mats at Loihi Seamount, Hawaii. To date, environmental clones from the Zetaproteobacteria have been detected at numerous sites with iron-rich mats, including the Loihi Seamount, Juan de Fuca Ridge, Guaymas Basin, Tonga-Kermadec Arc, East Lau Spreading Center, Vailulu’u Seamount, Southern Mariana Trough, and the Red Sea. More than 50 full-length (>1300bp) small subunit ribosomal gene (SSU rRNA gene) sequences representing more than 100 potential Zetaproteobacteria clones were identified using the Ribosomal Database Project (RDP) Version 10.14 seqmatch algorithm. Nine operational taxonomic units (OTUs) with more than three representative clones per OTU were detected based on a minimum similarity of 97% (DOTUR). Eight OTUs contained clones from more than one geographic region. The representative Zetaproteobacteria isolates (M. ferrooxydans JV-1 and PV-1) did not group in the top four most abundant OTUs. Each of the nine OTUs detected represents a unique, geographically dispersed Zetaproteobacteria phylotype, the most abundant of which still lack isolated representatives. Further attempts at detecting Zetaproteobacteria from more diverse geographic regions are required to characterize and expand the proposed phylogenetic groupings. In addition, more isolates are necessary to characterize the breath of Zetaproteobacteria physiology and metabolic potential.

  10. Discover Earth

    NASA Technical Reports Server (NTRS)

    Steele, Colleen

    1998-01-01

    Discover Earth is a NASA-sponsored project for teachers of grades 5-12, designed to: (1) enhance understanding of the Earth as an integrated system; (2) enhance the interdisciplinary approach to science instruction; and (3) provide classroom materials that focus on those goals. Discover Earth is conducted by the Institute for Global Environmental Strategies in collaboration with Dr. Eric Barron, Director, Earth System Science Center, The Pennsylvania State University; and Dr. Robert Hudson, Chair, the Department of Meteorology, University of Maryland at College Park. The enclosed materials: (1) represent only part of the Discover Earth materials; (2) were developed by classroom teachers who are participating in the Discover Earth project; (3) utilize an investigative approach and on-line data; and (4) can be effectively adjusted to classrooms with greater/without technology access. The Discover Earth classroom materials focus on the Earth system and key issues of global climate change including topics such as the greenhouse effect, clouds and Earth's radiation balance, surface hydrology and land cover, and volcanoes and climate change. All the materials developed to date are available on line at (http://www.strategies.org) You are encouraged to submit comments and recommendations about these materials to the Discover Earth project manager, contact information is listed below. You are welcome to duplicate all these materials.

  11. Discovering Deserts.

    ERIC Educational Resources Information Center

    Braus, Judy, Ed.

    1985-01-01

    Ranger Rick's NatureScope is a creative education series dedicated to inspiring in children an understanding and appreciation of the natural world while developing the skills they will need to make responsible decisions about the environment. The topic of this issue is "Discovering Deserts." Contents are organized into the following…

  12. Discovering Deserts.

    ERIC Educational Resources Information Center

    Braus, Judy, Ed.

    1985-01-01

    Ranger Rick's NatureScope is a creative education series dedicated to inspiring in children an understanding and appreciation of the natural world while developing the skills they will need to make responsible decisions about the environment. The topic of this issue is "Discovering Deserts." Contents are organized into the following…

  13. Chthonomonas calidirosea gen. nov., sp. nov., an aerobic, pigmented, thermophilic micro-organism of a novel bacterial class, Chthonomonadetes classis nov., of the newly described phylum Armatimonadetes originally designated candidate division OP10.

    PubMed

    Lee, Kevin C-Y; Dunfield, Peter F; Morgan, Xochitl C; Crowe, Michelle A; Houghton, Karen M; Vyssotski, Mikhail; Ryan, Jason L J; Lagutin, Kirill; McDonald, Ian R; Stott, Matthew B

    2011-10-01

    An aerobic, saccharolytic, obligately thermophilic, motile, non-spore-forming bacterium, strain T49(T), was isolated from geothermally heated soil at Hell's Gate, Tikitere, New Zealand. On the basis of 16S rRNA gene sequence similarity, T49(T) is the first representative of a new class in the newly described phylum Armatimonadetes, formerly known as candidate division OP10. Cells of strain T49(T) stained Gram-negative and were catalase-positive and oxidase-negative. Cells possessed a highly corrugated outer membrane. The major fatty acids were 16 : 0, i17 : 0 and ai17 : 0. The G+C content of the genomic DNA was 54.6 mol%. Strain T49(T) grew at 50-73 °C with an optimum temperature of 68 °C, and at pH 4.7-5.8 with an optimum growth pH of 5.3. A growth rate of 0.012 h(-1) was observed under optimal temperature and pH conditions. The primary respiratory quinone was MK-8. Optimal growth was achieved in the absence of NaCl, although growth was observed at NaCl concentrations as high as 2 % (w/v). Strain T49(T) was able to utilize mono- and disaccharides such as cellobiose, lactose, mannose and glucose, as well as branched or amorphous polysaccharides such as starch, CM-cellulose, xylan and glycogen, but not highly linear polysaccharides such as crystalline cellulose or cotton. On the basis of its phylogenetic position and phenotypic characteristics, we propose that strain T49(T) represents a novel bacterial genus and species within the new class Chthonomonadetes classis nov. of the phylum Armatimonadetes. The type strain of Chthonomonas calidirosea gen. nov., sp. nov. is T49(T) ( = DSM 23976(T) = ICMP 18418(T)).

  14. Zircon U-Pb ages and geochemistry of newly discovered Neoproterozoic orthogneisses in the Mishan region, NE China: Constraints on the high-grade metamorphism and tectonic affinity of the Jiamusi-Khanka Block

    NASA Astrophysics Data System (ADS)

    Yang, Hao; Ge, Wen-chun; Zhao, Guo-chun; Bi, Jun-hui; Wang, Zhi-hui; Dong, Yu; Xu, Wen-liang

    2017-01-01

    The Jiamusi-Khanka Block, located in the easternmost segment of the Central Asian Orogenic Belt (CAOB), is one of the least understood blocks in northeastern China. The age of its basement, the timing of the high-grade metamorphism, and the tectonic affinity of this block have all been subjects of controversy. Here we describe newly discovered Neoproterozoic orthogneisses from the Mishan region in the central Jiamusi-Khanka Block. SIMS and LA-ICP-MS U-Pb dating of the magmatic cores of zircons from three of these high-grade orthogneisses yielded weighted mean ages that range from 898 ± 4 to 891 ± 13 Ma, indicating that early Neoproterozoic magmatism did occur in the Jiamusi-Khanka Block. Twenty-two analyses of metamorphic zircons (rims as well as some grains) gave two groups of concordant ages, one at ca. 563 Ma, interpreted as the timing of the high-grade metamorphism, and the other around 518-496 Ma, interpreted as representing a subsequent retrograde metamorphism. The orthogneisses represent metamorphosed peraluminous syn-collisional syenogranites with SiO2 = 71.29-78.08 wt%, A/CNK = 1.06-1.99, and Na2O/K2O = 0.03-1.49, and they belong chemically to the high-potassium calc-alkaline series. They have low Sr (32-134 ppm) contents and Sr/Y ratios (1.6-16.9), and display strongly fractionated to nearly flat REE patterns with negative Eu anomalies (δEu = 0.22-0.95) and depletions in Nb-Ta. These geochemical characteristics suggest that the syenogranitic rocks were derived under low pressures from a crustal source with a high proportion of sedimentary rocks, perhaps in a subduction-related setting that was undergoing transition from compression to extension. In the context of the reconstruction of Gondwana, the ca. 898-891 Ma magmatic activity and the ca. 563 Ma high-grade metamorphism in the Mishan region provide constraints on the possible linkages between the Jiamusi-Khanka Block and East Gondwana during the Neoproterozoic to early Paleozoic.

  15. Bathymetric influence on dissolved methane in hydrothermal plumes revealed by concentration and stable carbon isotope measurements at newly discovered venting sites on the Central Indian Ridge (11-13°S)

    NASA Astrophysics Data System (ADS)

    You, Ok-Rye; Son, Seung Kyu; Baker, Edward T.; Son, Juwon; Kim, Mi Jin; Barcelona, Michael J.; Kim, Moonkoo

    2014-09-01

    Methane is a useful tracer for studying hydrothermal discharge, especially where the source fluids are of low temperature and lack metal precipitates. However, the dual origins of deep-sea methane, both chemical and biological, complicate the interpretation of methane observations. Here, we use both the concentration and stable carbon isotopic composition (δ13C) of dissolved methane to trace hydrothermal plumes and identify the source and behavior of methane at two sites of newly discovered hydrothermal activity on the Central Indian Ridge (11-13°S). At both sites, methane and optical anomalies between 2500 and 3500 m at all stations indicate active hydrothermal discharge. We compared methane concentrations and δ13C at three stations, two (CTIR110136 and CTIR110208) with the most prominent anomalies at each site, and a third (CTIR110140) with near-background methane values. At stations CTIR110136 and CTIR110208, the concentration and δ13C of methane in distinct plumes ranged from 3.3 to 42.3 nmol kg-1 and -30.0 to -15.4‰, respectively, compared to deep-water values of 0.5 to 1.2 nmol kg-1 and -35.1 to -28.9‰ at the station with a near-background distal plume (CTIR110140). δ13C was highest in the center of the plumes at CTIR110136 (-15.4‰) and CTIR110208 (-17.8‰). From the plume values we estimate that the δ13C of methane in the hydrothermal fluids at these stations was approximately -19‰ and thus the methane was most likely derived from magmatic outgassing or the chemical synthesis of inorganic matter. We used the relationship between δ13C and methane concentration to examine the behavior of methane at the plume stations. In the CTIR110208 plume, simple physical mixing was likely the major process controlling the methane profile. In the CTIR110136 plume we interpret a more complicated relationship as resulting from microbial oxidation as well as physical mixing. We argue that this difference in methane behavior between the two areas stems from a

  16. Discover Earth

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Discover Earth is a NASA-funded project for teachers of grades 5-12 who want to expand their knowledge of the Earth system, and prepare to become master teachers who promote Earth system science in their own schools, counties, and throughout their state. Participants from the following states are invited to apply: Connecticut, Delaware, Maine, Maryland, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, Vermont, and Washington, DC. Teachers selected for the project participate in a two-week summer workshop conducted at the University of Maryland, College Park; develop classroom-ready materials during the workshop for broad dissemination; conduct a minimum of two peer training activities during the coming school year; and participate in other enrichment/education opportunities as available and desired. Discover Earth is a team effort that utilizes expertise from a range of contributors, and balances science content with hands-on classroom applications.

  17. Aerobic Anoxygenic Phototrophic Bacteria

    PubMed Central

    Yurkov, Vladimir V.; Beatty, J. Thomas

    1998-01-01

    The aerobic anoxygenic phototrophic bacteria are a relatively recently discovered bacterial group. Although taxonomically and phylogenetically heterogeneous, these bacteria share the following distinguishing features: the presence of bacteriochlorophyll a incorporated into reaction center and light-harvesting complexes, low levels of the photosynthetic unit in cells, an abundance of carotenoids, a strong inhibition by light of bacteriochlorophyll synthesis, and the inability to grow photosynthetically under anaerobic conditions. Aerobic anoxygenic phototrophic bacteria are classified in two marine (Erythrobacter and Roseobacter) and six freshwater (Acidiphilium, Erythromicrobium, Erythromonas, Porphyrobacter, Roseococcus, and Sandaracinobacter) genera, which phylogenetically belong to the α-1, α-3, and α-4 subclasses of the class Proteobacteria. Despite this phylogenetic information, the evolution and ancestry of their photosynthetic properties are unclear. We discuss several current proposals for the evolutionary origin of aerobic phototrophic bacteria. The closest phylogenetic relatives of aerobic phototrophic bacteria include facultatively anaerobic purple nonsulfur phototrophic bacteria. Since these two bacterial groups share many properties, yet have significant differences, we compare and contrast their physiology, with an emphasis on morphology and photosynthetic and other metabolic processes. PMID:9729607

  18. Large solar system planetoid discovered

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    A newly discovered planetoid, currently dubbed 2004 UN, could be confirmed as the largest such known body in the Kuiper Belt, scientists announced on 19 February.The planetoid, located about 4.4 billion miles from Earth, is estimated at about 1,400 kilometers in diameter, according to Michael Brown, associate professor of planetary astronomy at the California Institute of Technology.

  19. Corrigendum to ;Insights into methane dynamics from analysis of authigenic carbonates and chemosynthetic mussels at newly-discovered Atlantic Margin seeps; [Earth Planet. Sci. Lett. 449 (2016) 332-344

    NASA Astrophysics Data System (ADS)

    Prouty, N. G.; Sahy, D.; Ruppel, C. D.; Roark, E. B.; Condon, D.; Brooke, S.; Ross, S. W.; Demopoulos, A. W. J.

    2017-10-01

    The authors have discovered a calculation error in reporting the assumed Δ14C signature of methane. According to Pohlman et al. (2009), the lower limit of gas-hydrate bearing methane is 0.12 pMC, equivalent to -998.8‰

  20. Aerobic granular sludge: recent advances.

    PubMed

    Adav, Sunil S; Lee, Duu-Jong; Show, Kuan-Yeow; Tay, Joo-Hwa

    2008-01-01

    Aerobic granulation, a novel environmental biotechnological process, was increasingly drawing interest of researchers engaging in work in the area of biological wastewater treatment. Developed about one decade ago, it was exciting research work that explored beyond the limits of aerobic wastewater treatment such as treatment of high strength organic wastewaters, bioremediation of toxic aromatic pollutants including phenol, toluene, pyridine and textile dyes, removal of nitrogen, phosphate, sulphate and nuclear waste and adsorption of heavy metals. Despite this intensive research the mechanisms responsible for aerobic granulation and the strategy to expedite the formation of granular sludge, and effects of different operational and environmental factors have not yet been clearly described. This paper provides an up-to-date review on recent research development in aerobic biogranulation technology and applications in treating toxic industrial and municipal wastewaters. Factors affecting granulation, granule characterization, granulation hypotheses, effects of different operational parameters on aerobic granulation, response of aerobic granules to different environmental conditions, their applications in bioremediations, and possible future trends were delineated. The review attempts to shed light on the fundamental understanding in aerobic granulation by newly employed confocal laser scanning microscopic techniques and microscopic observations of granules.

  1. A new intra-aerobic metabolism in the nitrite-dependent anaerobic methane-oxidizing bacterium Candidatus 'Methylomirabilis oxyfera'.

    PubMed

    Wu, Ming L; Ettwig, Katharina F; Jetten, Mike S M; Strous, Marc; Keltjens, Jan T; van Niftrik, Laura

    2011-01-01

    Biological methane oxidation proceeds either through aerobic or anaerobic pathways. The newly discovered bacterium Candidatus 'Methylomirabilis oxyfera' challenges this dichotomy. This bacterium performs anaerobic methane oxidation coupled to denitrification, but does so in a peculiar way. Instead of scavenging oxygen from the environment, like the aerobic methanotrophs, or driving methane oxidation by reverse methanogenesis, like the methanogenic archaea in sulfate-reducing systems, it produces its own supply of oxygen by metabolizing nitrite via nitric oxide into oxygen and dinitrogen gas. The intracellularly produced oxygen is then used for the oxidation of methane by the classical aerobic methane oxidation pathway involving methane mono-oxygenase. The present mini-review summarizes the current knowledge about this process and the micro-organism responsible for it.

  2. Aerobic glycolysis: beyond proliferation.

    PubMed

    Jones, William; Bianchi, Katiuscia

    2015-01-01

    Aerobic glycolysis has been generally associated with cancer cell proliferation, but fascinating and novel data show that it is also coupled to a series of further cellular functions. In this Mini Review, we will discuss some recent findings to illustrate newly defined roles for this process, in particular in non-malignant cells, supporting the idea that metabolism can be considered as an integral part of cellular signaling. Consequently, metabolism should be regarded as a plastic and highly dynamic determinant of a wide range of cellular specific functions.

  3. Aerobic Tennis.

    ERIC Educational Resources Information Center

    Stewart, Michael J.; Ahlschwede, Robert

    1989-01-01

    Increasing the aerobic nature of tennis drills in the physical education class may be necessary if tennis is to remain a part of the public school curriculum. This article gives two examples of drills that can be modified by teachers to increase activity level. (IAH)

  4. Three newly discovered sub-Jupiter-mass planets: WASP-69b and WASP-84b transit active K dwarfs and WASP-70Ab transits the evolved primary of a G4+K3 binary

    NASA Astrophysics Data System (ADS)

    Anderson, D. R.; Collier Cameron, A.; Delrez, L.; Doyle, A. P.; Faedi, F.; Fumel, A.; Gillon, M.; Gómez Maqueo Chew, Y.; Hellier, C.; Jehin, E.; Lendl, M.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Ségransan, D.; Skillen, I.; Smalley, B.; Smith, A. M. S.; Southworth, J.; Triaud, A. H. M. J.; Turner, O. D.; Udry, S.; West, R. G.

    2014-12-01

    We report the discovery of the transiting exoplanets WASP-69b, WASP-70Ab and WASP-84b, each of which orbits a bright star (V ˜ 10). WASP-69b is a bloated Saturn-mass planet (0.26 MJup, 1.06 RJup) in a 3.868-d period around an active, ˜1-Gyr, mid-K dwarf. ROSAT detected X-rays 60±27 arcsec from WASP-69. If the star is the source then the planet could be undergoing mass-loss at a rate of ˜1012 g s-1. This is one to two orders of magnitude higher than the evaporation rate estimated for HD 209458b and HD 189733b, both of which have exhibited anomalously large Lyman α absorption during transit. WASP-70Ab is a sub-Jupiter-mass planet (0.59 MJup, 1.16 RJup) in a 3.713-d orbit around the primary of a spatially resolved, 9-10-Gyr, G4+K3 binary, with a separation of 3.3 arcsec (≥800 au). WASP-84b is a sub-Jupiter-mass planet (0.69 MJup, 0.94 RJup) in an 8.523-d orbit around an active, ˜1-Gyr, early-K dwarf. Of the transiting planets discovered from the ground to date, WASP-84b has the third-longest period. For the active stars WASP-69 and WASP-84, we pre-whitened the radial velocities using a low-order harmonic series. We found that this reduced the residual scatter more than did the oft-used method of pre-whitening with a fit between residual radial velocity and bisector span. The system parameters were essentially unaffected by pre-whitening.

  5. Aerobic Physical Activity and the Leadership of Principals

    ERIC Educational Resources Information Center

    Kiser, Kari

    2016-01-01

    The purpose of this study was to explore if there was a connection between regular aerobic physical activity and the stress and energy levels of principals as they reported it. To begin the research, the current aerobic physical activity level of principals was discovered. Additionally, the energy and stress levels of the principals who do engage…

  6. Aerobic Physical Activity and the Leadership of Principals

    ERIC Educational Resources Information Center

    Kiser, Kari

    2016-01-01

    The purpose of this study was to explore if there was a connection between regular aerobic physical activity and the stress and energy levels of principals as they reported it. To begin the research, the current aerobic physical activity level of principals was discovered. Additionally, the energy and stress levels of the principals who do engage…

  7. Effectiveness of the modified progressive aerobic capacity endurance run test for assessing aerobic fitness in Hispanic children who are obese

    USDA-ARS?s Scientific Manuscript database

    The purpose of this study was to evaluate the effectiveness of the progressive aerobic capacity endurance run (PACER) and a newly designed modified PACER (MPACER) for assessing aerobic fitness in Hispanic children who are obese. Thirty-nine (aged 7-12 years) children who were considered obese (= 95 ...

  8. Explore and Discover

    NASA Image and Video Library

    Train to improve your aerobic and anaerobic fitness by carrying weighted objects in this activity. The Train Like an Astronaut project uses the excitement of exploration to challenge students to se...

  9. A newly discovered human α-globin gene

    PubMed Central

    Goh, Sung-Ho; Lee, Y. Terry; Bhanu, Natarajan V.; Cam, Margaret C.; Desper, Richard; Martin, Brian M.; Moharram, Ramy; Gherman, Robert B.; Miller, Jeffery L.

    2005-01-01

    A previously undefined transcript with significant homology to the pseudo-α2 region of the α-globin locus on human chromosome 16 was detected as part of an effort to better define the transcriptional profiles of human reticulocytes. Cloning and sequencing of that transcript (GenBank AY698022; named μ-globin) revealed an insert with a 423-nucleotide open reading frame. BLASTP and ClustalW and phylogenetic analyses of the predicted protein demonstrated a high level of homology with the avian α-D globin. In addition, the heme- and globin-binding amino acids of μ-globin and avian α-D globin are largely conserved. Using quantitative real-time polymerase chain reaction (PCR), μ-globin was detected at a level of approximately 0.1% that measured for α-globin in erythroid tissues. Erythroid-specific expression was detected by Northern blot analysis, and maximal expression during the erythroblast terminal differentiation was also detected. Despite this highly regulated pattern of μ-globin gene transcription, μ-globin protein was not detected by mass spectrometry. These results suggest the human genome encodes a previously unrecognized globin member of the avian α-D family that is transcribed in a highly regulated pattern in erythroid cells. (Blood. 2005;106:1466-1472) PMID:15855277

  10. Human Muscle Phosphoglycerate Mutase Deficiency: Newly Discovered Metabolic Myopathy

    NASA Astrophysics Data System (ADS)

    Dimauro, Salvatore; Miranda, Armand F.; Khan, Shahnaz; Gitlin, Kevin; Friedman, Robert

    1981-06-01

    Muscle phosphoglycerate mutase activity was decreased (5.7 percent of the lowest control value) in a 52-year-old man with intolerance for strenuous exercise and recurrent pigmenturia since adolescence. All of the other enzymes of glycolysis had normal activities, and glycogen concentration was normal. Electrophoretic, heat lability, and mercury inhibition studies showed that the small residual activity in the patient's muscle was represented by the brain (BB) isoenzyme of phosphoglycerate mutase, suggesting a genetic defect of the M subunit which predominates in normal muscle. The prevalence of the BB isoenzyme in other tissues, including muscle culture, may explain why symptoms were confined to muscle.

  11. Antioxidant activity of newly discovered lineage of marine actinobacteria.

    PubMed

    Karthik, Loganathan; Kumar, Gaurav; Bhaskara Rao, Kokati Venkata

    2013-04-13

    To investigate the antioxidant activity of marine actinobacteria. The content of total phenolics, the level of antioxidant potential by DPPH radical scavenging activity, metal chelating activity, FRAP method, β carotene assay and NO scavenging activity in extract were determined. In all the methods the extract exhibited good scavenging activity except NO scavenging activity. The IC(50) values of marine actinobacteria extract on DPPH radical were found to be 41.09 μg/mL. The zone of color retention was 12 mm in β-carotene bleaching assay. DNA protective efficiency of the extracts was also studied using UV-photolysed H(2)O(2)-driven oxidative damage to pBR322. HPLC analysis identified some of the major phenolic compounds in extracts, which might be responsible for the antioxidant potential and cyto-protection. It showed a 100% cytotoxic effect in brine shrimp lethality assay within 10 mins. The novel actinobacteria was identified as Streptomyces LK-3 (JF710608) through 16S rDNA Sequencing. The results obtained suggest that the extracts bear anti-cancer metabolites and could be considered as a potential source for anti-cancer drug development. Copyright © 2013 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  12. tirant, a newly discovered active endogenous retrovirus in Drosophila simulans.

    PubMed

    Akkouche, Abdou; Rebollo, Rita; Burlet, Nelly; Esnault, Caroline; Martinez, Sonia; Viginier, Barbara; Terzian, Christophe; Vieira, Cristina; Fablet, Marie

    2012-04-01

    Endogenous retroviruses have the ability to become permanently integrated into the genomes of their host, and they are generally transmitted vertically from parent to progeny. With the exception of gypsy, few endogenous retroviruses have been identified in insects. In this study, we describe the tirant endogenous retrovirus in a subset of Drosophila simulans natural populations. By focusing on the envelope gene, we show that the entire retroviral cycle (transcription, translation, and retrotransposition) can be completed for tirant within one population of this species.

  13. Newly Discovered B[e] Stars in the Magellanic Clouds

    NASA Astrophysics Data System (ADS)

    Kamath, D.; Van Winckel, H.; Wood, P. R.

    2017-02-01

    We report on the detection of a new sample of objects, in the Large Magellanic Cloud (LMC), that likely show signatures of the B[e] phenomenon. The discovery of this sample was a by-product of our extensive low-resolution optical spectroscopic survey of post-Asymptotic Giant Branch (post-AGB) candidates in the LMC. It is known that post-AGB binaries are surrounded by a stable, dusty disc similar to that observed in objects that show the B[e] phenomenon. A few of the already known LMC objects that display the B[e] phenomenon were therefore recovered in our survey. However, interestingly, we found several other objects, spread across various evolutionary phases, with signatures of the B[e] phenomenon. Our observations corroborates the fact that the B[e] phenomenon can be active during several phases of stellar evolution. On analyzing the SED of our new sample of likely B[e] candidates, we found that all these objects show the presence of a dusty disc. Here we present a preliminary list and study on these new B[e] candidates.

  14. The Canarias Einstein ring: a newly discovered optical Einstein ring

    NASA Astrophysics Data System (ADS)

    Bettinelli, M.; Simioni, M.; Aparicio, A.; Hidalgo, S. L.; Cassisi, S.; Walker, A. R.; Piotto, G.; Valdes, F.

    2016-09-01

    We report the discovery of an optical Einstein ring in the Sculptor constellation, IAC J010127-334319, in the vicinity of the Sculptor dwarf spheroidal galaxy. It is an almost complete ring (˜300°) with a diameter of ˜4.5 arcsec. The discovery was made serendipitously from inspecting Dark Energy Camera (DECam) archive imaging data. Confirmation of the object nature has been obtained by deriving spectroscopic redshifts for both components, lens and source, from observations at the 10.4 m Gran Telescopio CANARIAS (GTC) with the spectrograph OSIRIS. The lens, a massive early-type galaxy, has a redshift of z = 0.581, while the source is a starburst galaxy with redshift of z = 1.165. The total enclosed mass that produces the lensing effect has been estimated to be Mtot = (1.86 ± 0.23) × 1012 M⊙.

  15. Young Debris Disks With Newly Discovered Emission Features

    NASA Astrophysics Data System (ADS)

    Ballering, N.

    2014-04-01

    We analyzed the Spitzer/IRS spectra of young A and F stars that host debris disks with previously unidentified silicate emission features. Such features probe small, warm dust grains in the inner regions of these young systems where terrestrial planet formation may be proceeding (Lisse et al. 2009). For most systems, these regions are too near their host star to be directly seen with high-contrast imaging and too warm to be imaged with submillimeter interferometers. Mid-infrared excess spectra - originating from the thermal emission of the debris disk dust - remain the best data to constrain the properties of the debris in these regions. For each target, we fit physically-motivated model spectra to the data. Typical spectra of unresolved debris disks are featureless and suffer severe degeneracies between the dust location and the grain properties; however, spectra with solid-state emission features provide significantly more information, allowing for a more accurate determination of the dust size, composition, and location (e.g. Chen et al. 2006; Olofsson et al. 2012). Our results shed light on the dynamic properties occurring in the terrestrial regions of these systems. For instance, the sizes of the smallest grains and the nature of the grain size distribution reveal whether the dust originates from steady-state collisional cascades or from stochastic collisions. The properties of the dust grains - such as their crystalline or amorphous structure - can inform us of grain processing mechanisms in the disk. The location of this debris illuminates where terrestrial planet forming activity is occurring. We used results from the Beta Pictoris - which has a well-resolved debris disk with emission features (Li et al. 2012) - to place our results in context. References: Chen et al. 2006, ApJS, 166, 351 Li et al. 2012, ApJ, 759, 81 Lisse et al. 2009, ApJ, 701, 2019 Olofsson et al. 2012, A&A, 542, A90

  16. Blood iron homeostasis: newly discovered proteins and iron imbalance.

    PubMed

    Bleackley, Mark R; Wong, Ann Y K; Hudson, David M; Wu, Christopher H-Y; Macgillivray, Ross T A

    2009-04-01

    In biological systems, iron exerts 2 contrasting effects. The chemical reactivity of iron is essential for the biological activities of proteins such as hemoglobin, ribonucleotide reductase, the cytochromes, and aconitases. However, free iron in a cell has the propensity to generate free radicals which can damage cellular components containing proteins, lipids, and nucleic acids. To maintain the balance between iron as an essential nutrient and iron as a potential cytotoxin, a number of biological protective mechanisms have evolved. As shown in the thalassemias, iron imbalance can have devastating effects on human health. Recently, several new proteins have been described that play critical roles in iron regulation including the master regulator of iron metabolism (hepcidin). In this review, we discuss the new knowledge that has arisen from studies in yeast and in humans, and we show how these studies are shedding new light on some well-known human disorders.

  17. Cardiovascular effects of newly discovered peptide intermedin/adrenomedullin 2.

    PubMed

    Pan, Chun-Shui; Yang, Jing-Hui; Cai, Da-Yong; Zhao, Jing; Gerns, Helen; Yang, Jun; Chang, Jaw-Kang; Tang, Chao-Shu; Qi, Yong-Fen

    2005-09-01

    Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide (CGRP). The present study aimed to investigate the cardiovascular effects of IMDs (IMD1-47 and IMD8-47) in rats. Intravenous administration of 150 nmol IMDs continuously decreased mean arterial pressure and inhibited cardiac function. Administration with IMDs decreased left ventricular end-systolic pressure (LVESP) and maximal rate of left-ventricle pressure development (+/-LVdp/dt(max)), and elevated left ventricular end-diastolic pressure (LVEDP). Changes with IMD1-47 treatment were close to that with IMD8-47 (P>0.05). Perfusion of isolated rat hearts in vitro with IMD8-47 (10(-8) and 10(-7)mol/L) resulted in lower LVSP, by 40 and 56% (P<0.01); lower +LVdp/dt (max), by 33 and 47% (P<0.01); lower -LVdp/dt(max), by 25 and 39% (P<0.01); but higher coronary perfusion flow (CPF), by 25% (P<0.05) and 33% (P<0.01), respectively, than controls. However, both IMD8-47 and IMD1-47 (from 10(-13) to 10(-7)mol/L) relaxed preconstricted aortic rings in a dose-dependent manner. Intravenous administration of IMD1-47 and IMD8-47 (10(-7)mol/L) in vivo increased the cyclic adenosine monophosphate (cAMP) content by 68 and 150% (both P<0.01), respectively, in myocardia and 320 and 281% (both P<0.01), respectively, in aortas, compared with controls. Perfusion of isolated hearts with IMD1-47 and IMD8-47 (10(-7)mol/L) enhanced cAMP content by 24% (P<0.05) and 73% (P<0.01), respectively, compared with controls. IMDs inhibited 3H-Leucine incorporation in cardiomyocytes in a concentration-dependent manner. IMD1-47 and IMD8-47 (10(-7) and 10(-8)mol/L) decreased 3H-Leucine incorporation by 12-25% (P<0.01) and 14-18% (P<0.01), respectively. IMD mRNA was detected in cultured neonatal cardiomyocytes and isoproterenol-induced hypertrophic myocardia but not normal myocardia of adult rats. These results suggest that IMD might be a regulatory factor for cardiovascular function and myocardial hypertrophy as a cardiovascular active peptide.

  18. Newly discovered sister lineage sheds light on early ant evolution

    PubMed Central

    Rabeling, Christian; Brown, Jeremy M.; Verhaagh, Manfred

    2008-01-01

    Ants are the world's most conspicuous and important eusocial insects and their diversity, abundance, and extreme behavioral specializations make them a model system for several disciplines within the biological sciences. Here, we report the discovery of a new ant that appears to represent the sister lineage to all extant ants (Hymenoptera: Formicidae). The phylogenetic position of this cryptic predator from the soils of the Amazon rainforest was inferred from several nuclear genes, sequenced from a single leg. Martialis heureka (gen. et sp. nov.) also constitutes the sole representative of a new, morphologically distinct subfamily of ants, the Martialinae (subfam. nov.). Our analyses have reduced the likelihood of long-branch attraction artifacts that have troubled previous phylogenetic studies of early-diverging ants and therefore solidify the emerging view that the most basal extant ant lineages are cryptic, hypogaeic foragers. On the basis of morphological and phylogenetic evidence we suggest that these specialized subterranean predators are the sole surviving representatives of a highly divergent lineage that arose near the dawn of ant diversification and have persisted in ecologically stable environments like tropical soils over great spans of time. PMID:18794530

  19. On the nature of the newly discovered Ω states

    NASA Astrophysics Data System (ADS)

    Agaev, S. S.; Azizi, K.; Sundu, H.

    2017-06-01

    The mass and residue of the ground-state, as well as the first orbital and radial excitations of the heavy ΩQ baryons with Q being b or c quark, for both J=1/2 and J=3/2 are calculated by means of the QCD two-point sum rule method using the general forms for the interpolating currents. In the calculations the quark, gluon and mixed vacuum condensates up to ten dimensions are taken into account. We compare our results for the masses of Ω_b- and Ω_c0 baryons with the existing predictions of other theoretical works. Our results for the charmed baryons are confronted with the experimental data of the LHCb Collaboration to understand the nature of the recently observed narrow Ω_c0 resonances. The predictions for the masses of the Ω_b- baryons with the same quantum numbers may shed light on future experimental searches for the corresponding bottom baryons.

  20. tirant, a Newly Discovered Active Endogenous Retrovirus in Drosophila simulans

    PubMed Central

    Akkouche, Abdou; Rebollo, Rita; Burlet, Nelly; Esnault, Caroline; Martinez, Sonia; Viginier, Barbara; Terzian, Christophe; Vieira, Cristina

    2012-01-01

    Endogenous retroviruses have the ability to become permanently integrated into the genomes of their host, and they are generally transmitted vertically from parent to progeny. With the exception of gypsy, few endogenous retroviruses have been identified in insects. In this study, we describe the tirant endogenous retrovirus in a subset of Drosophila simulans natural populations. By focusing on the envelope gene, we show that the entire retroviral cycle (transcription, translation, and retrotransposition) can be completed for tirant within one population of this species. PMID:22278247

  1. Microglia: a newly discovered role in visceral hypersensitivity?

    PubMed Central

    Saab, Carl Y.; Wang, Jing; Gu, Chunping; Garner, Kirsten N.; Al-Chaer, Elie D.

    2007-01-01

    Given the growing body of evidence for a role of glia in pain modulation, it is plausible that the exaggerated visceral pain in chronic conditions might be regulated by glial activation. In this study, we have investigated a possible role for microglia in rats with chronic visceral hypersensitivity and previously documented altered neuronal function. Experiments were performed on adult male Sprague-Dawley rats pre-treated with neonatal colon irritation (CI) and on control rats. Effects of fractalkine (FKN, a chemokine involved in neuron-to-microglia signaling) and of minocycline (an inhibitor of microglia) on visceral sensitivity were examined. Visceral sensitivity was assessed by recording the electromyographic (EMG) responses to graded colorectal distension (CRD) in mildly sedated rats. Responses to CRD were recorded before and after injection of FKN, minocycline or vehicle. Somatic thermal hyperalgesia was measured by latency of paw withdrawal to radiant heat. The pattern and intensity of microglial distribution at L6–S2 in the spinal cord was also compared in rats with CI and controls by fluorescence microscopy using OX-42. Results show that: (1) FKN significantly facilitated EMG responses to noxious CRD by >52% in control rats. FKN also induced thermal hyperalgesia in control rats, consistent with previous reports; (2) minocycline significantly inhibited EMG responses to noxious CRD by >70% in rats with CI compared to controls 60 min after injection. The anti-nociceptive effect of minocycline lasted for 180 min in rats with CI, reaching peak values 60 min after injection. Our results show that FKN enhances visceral and somatic nociception, whereas minocycline inhibits visceral hypersensitivity in chronically sensitized rats, which indicates a role for microglia in visceral hypersensitivity. PMID:18496611

  2. A newly discovered founder population: the Roma/Gypsies.

    PubMed

    Kalaydjieva, Luba; Morar, Bharti; Chaix, Raphaelle; Tang, Hua

    2005-10-01

    The Gypsies (a misnomer, derived from an early legend about Egyptian origins) defy the conventional definition of a population: they have no nation-state, speak different languages, belong to many religions and comprise a mosaic of socially and culturally divergent groups separated by strict rules of endogamy. Referred to as "the invisible minority", the Gypsies have for centuries been ignored by Western medicine, and their genetic heritage has only recently attracted attention. Common origins from a small group of ancestors characterise the 8-10 million European Gypsies as an unusual trans-national founder population, whose exodus from India played the role of a profound demographic bottleneck. Social and economic pressures within Europe led to gradual fragmentation, generating multiple genetically differentiated subisolates. The string of population bottlenecks and founder effects have shaped a unique genetic profile, whose potential for genetic research can be met only by study designs that acknowledge cultural tradition and self-identity. (c) 2005 Wiley Periodicals, Inc.

  3. Asteroid 4296 Van Woerkom: A Newly Discovered Asynchronous Binary

    NASA Astrophysics Data System (ADS)

    Odden, Caroline E.; Caso, Maria; Dettorre, Christopher; Dial, Preston J.; Hoang, Kaitlin; Lazar, Travor T.; Morss, Paige P.; Mundra, Akshay R.; Naiyapatana, Abhichana; Rooney, Morgan; Pravec, Petr; Benishek, Vladimir; Klinglesmith, Dan; Pilcher, Frederick

    2017-07-01

    We report that asteroid 4296 van Woerkom is a binary asteroid. Lightcurve analysis for images taken from 2016 November through December reveals a primary rotational period of 2.80868 ± 0.00005 h and a secondary orbital period of 26.22 ± 0.01 h.

  4. Newly discovered landscape traps produce regime shifts in wet forests

    PubMed Central

    Lindenmayer, David B.; Hobbs, Richard J.; Likens, Gene E.; Krebs, Charles J.; Banks, Samuel C.

    2011-01-01

    We describe the “landscape trap” concept, whereby entire landscapes are shifted into, and then maintained (trapped) in, a highly compromised structural and functional state as the result of multiple temporal and spatial feedbacks between human and natural disturbance regimes. The landscape trap concept builds on ideas like stable alternative states and other relevant concepts, but it substantively expands the conceptual thinking in a number of unique ways. In this paper, we (i) review the literature to develop the concept of landscape traps, including their general features; (ii) provide a case study as an example of a landscape trap from the mountain ash (Eucalyptus regnans) forests of southeastern Australia; (iii) suggest how landscape traps can be detected before they are irrevocably established; and (iv) present evidence of the generality of landscape traps in different ecosystems worldwide. PMID:21876151

  5. Newly discovered young CORE-SINEs in marsupial genomes.

    PubMed

    Munemasa, Maruo; Nikaido, Masato; Nishihara, Hidenori; Donnellan, Stephen; Austin, Christopher C; Okada, Norihiro

    2008-01-15

    Although recent mammalian genome projects have uncovered a large part of genomic component of various groups, several repetitive sequences still remain to be characterized and classified for particular groups. The short interspersed repetitive elements (SINEs) distributed among marsupial genomes are one example. We have identified and characterized two new SINEs from marsupial genomes that belong to the CORE-SINE family, characterized by a highly conserved "CORE" domain. PCR and genomic dot blot analyses revealed that the distribution of each SINE shows distinct patterns among the marsupial genomes, implying different timing of their retroposition during the evolution of marsupials. The members of Mar3 (Marsupialia 3) SINE are distributed throughout the genomes of all marsupials, whereas the Mac1 (Macropodoidea 1) SINE is distributed specifically in the genomes of kangaroos. Sequence alignment of the Mar3 SINEs revealed that they can be further divided into four subgroups, each of which has diagnostic nucleotides. The insertion patterns of each SINE at particular genomic loci, together with the distribution patterns of each SINE, suggest that the Mar3 SINEs have intensively amplified after the radiation of diprotodontians, whereas the Mac1 SINE has amplified only slightly after the divergence of hypsiprimnodons from other macropods. By compiling the information of CORE-SINEs characterized to date, we propose a comprehensive picture of how SINE evolution occurred in the genomes of marsupials.

  6. Aerobic exercise (image)

    MedlinePlus

    Aerobic exercise gets the heart working to pump blood through the heart more quickly and with more ... must be oxygenated more quickly, which quickens respiration. Aerobic exercise strengthens the heart and boosts healthy cholesterol ...

  7. Teaching Aerobic Fitness Concepts.

    ERIC Educational Resources Information Center

    Sander, Allan N.; Ratliffe, Tom

    2002-01-01

    Discusses how to teach aerobic fitness concepts to elementary students. Some of the K-2 activities include location, size, and purpose of the heart and lungs; the exercise pulse; respiration rate; and activities to measure aerobic endurance. Some of the 3-6 activities include: definition of aerobic endurance; heart disease risk factors;…

  8. Teaching Aerobic Fitness Concepts.

    ERIC Educational Resources Information Center

    Sander, Allan N.; Ratliffe, Tom

    2002-01-01

    Discusses how to teach aerobic fitness concepts to elementary students. Some of the K-2 activities include location, size, and purpose of the heart and lungs; the exercise pulse; respiration rate; and activities to measure aerobic endurance. Some of the 3-6 activities include: definition of aerobic endurance; heart disease risk factors;…

  9. The Effectiveness of DISCOVER.

    ERIC Educational Resources Information Center

    Engel, Elaine Frances

    Computer assisted career guidance (CACG) systems have been around for at least the past 20 years in career guidance centers. There are two types of systems: information retrieval and guidance interaction. This study investigated the effectiveness of DISCOVER in facilitating career decisions among college students. DISCOVER is a systematic career…

  10. Biological Activity of Recently Discovered Halogenated Marine Natural Products

    PubMed Central

    Gribble, Gordon W.

    2015-01-01

    This review presents the biological activity—antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity—of halogenated marine natural products discovered in the past five years. Newly discovered examples that do not report biological activity are not included. PMID:26133553

  11. Discovering Hidden Voices.

    ERIC Educational Resources Information Center

    Collins, Carol

    1991-01-01

    Working with teachers and artists from Florida to Maine, a drama educator has discovered that creative power and insight can emerge when using drama in the language arts classroom. One seventh-grade class began with simple warm-ups to loosen inhibitions and then moved into a unit that dealt with improvising using movement. A student who had hardly…

  12. DISCOVER-AQ

    Atmospheric Science Data Center

    2017-01-31

    ... DISCOVER-AQ ) is a four-year campaign to improve the use of satellites to monitor air quality for public health and environmental benefit. ... will enable more effective use of current and future satellites to diagnose ground level conditions influencing air quality. ...

  13. Discovering Mendeleev's Model.

    ERIC Educational Resources Information Center

    Sterling, Donna

    1996-01-01

    Presents an activity that introduces the historical developments in science that led to the discovery of the periodic table and lets students experience scientific discovery firsthand. Enables students to learn about patterns among the elements and experience how scientists analyze data to discover patterns and build models. (JRH)

  14. Discovering the Artist Within.

    ERIC Educational Resources Information Center

    Hamill, Sam

    1999-01-01

    Describes a personal artistic struggle against heroin addiction, advising teachers of the difficulty of working to discover and express one's developing self. Considers the effect of poetry and philosophy on the developing creative process. Provides samples of the author's own poetry to demonstrate creative development, as an example to Montessori…

  15. Discovering Mendeleev's Model.

    ERIC Educational Resources Information Center

    Sterling, Donna

    1996-01-01

    Presents an activity that introduces the historical developments in science that led to the discovery of the periodic table and lets students experience scientific discovery firsthand. Enables students to learn about patterns among the elements and experience how scientists analyze data to discover patterns and build models. (JRH)

  16. [Testing aerobic power].

    PubMed

    Lehance, C; Bury, T

    2008-01-01

    Maximal oxygen uptake (VO2 max) is regarded by some as the best single measurement of aerobic fitness. An other major determinant of successful endurance performance is the percentage of VO2 max that an athlete can maintain for a prolonged period. It is related to the lactate threshold. Two other factors also appear to be important for endurance activities as high economy of effort, or low VO2 value for the same rate of work; high percentage of ST muscle fibers. In the laboratory, the usual measurements of aerobic power include the determination of maximum oxygen consumption and the identification of lactate threshold. Testing aerobic power can help determine the type of aerobic training that should be emphasized.

  17. Aerobic Conditioning Class.

    ERIC Educational Resources Information Center

    Johnson, Neil R.

    1980-01-01

    An aerobic exercise class that focuses on the conditioning of the cardiovascular and muscular systems is presented. Students complete data cards on heart rate, pulse, and exercises to be completed during the forty minute course. (CJ)

  18. NASA's Kepler Mission Discovers First Earth-size Planet in Habitable Zone of Another Star (Reporter Package)

    NASA Image and Video Library

    2014-04-17

    NASA's Kepler mission has discovered the first Earth-size planet orbiting in the habitable zone of a star outside our solar system. The newly discovered planet is called Kepler-186f and is about 10 percent larger than Earth.

  19. Students Discover Unique Planet

    NASA Astrophysics Data System (ADS)

    2008-12-01

    Three undergraduate students, from Leiden University in the Netherlands, have discovered an extrasolar planet. The extraordinary find, which turned up during their research project, is about five times as massive as Jupiter. This is also the first planet discovered orbiting a fast-rotating hot star. Omega Centauri ESO PR Photo 45a/08 A planet around a hot star The students were testing a method of investigating the light fluctuations of thousands of stars in the OGLE database in an automated way. The brightness of one of the stars was found to decrease for two hours every 2.5 days by about one percent. Follow-up observations, taken with ESO's Very Large Telescope in Chile, confirmed that this phenomenon is caused by a planet passing in front of the star, blocking part of the starlight at regular intervals. According to Ignas Snellen, supervisor of the research project, the discovery was a complete surprise. "The project was actually meant to teach the students how to develop search algorithms. But they did so well that there was time to test their algorithm on a so far unexplored database. At some point they came into my office and showed me this light curve. I was completely taken aback!" The students, Meta de Hoon, Remco van der Burg, and Francis Vuijsje, are very enthusiastic. "It is exciting not just to find a planet, but to find one as unusual as this one; it turns out to be the first planet discovered around a fast rotating star, and it's also the hottest star found with a planet," says Meta. "The computer needed more than a thousand hours to do all the calculations," continues Remco. The planet is given the prosaic name OGLE2-TR-L9b. "But amongst ourselves we call it ReMeFra-1, after Remco, Meta, and myself," says Francis. The planet was discovered by looking at the brightness variations of about 15 700 stars, which had been observed by the OGLE survey once or twice per night for about four years between 1997 and 2000. Because the data had been made public

  20. Discovering system requirements

    SciTech Connect

    Bahill, A.T.; Bentz, B.; Dean, F.F.

    1996-07-01

    Cost and schedule overruns are often caused by poor requirements that are produced by people who do not understand the requirements process. This report provides a high-level overview of the system requirements process, explaining types, sources, and characteristics of good requirements. System requirements, however, are seldom stated by the customer. Therefore, this report shows ways to help you work with your customer to discover the system requirements. It also explains terminology commonly used in the requirements development field, such as verification, validation, technical performance measures, and the various design reviews.

  1. Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats

    PubMed Central

    Marton, Orsolya; Koltai, Erika; Takeda, Masaki; Koch, Lauren Gerard; Britton, Steven L.; Davies, Kelvin J.A.; Boldogh, Istvan; Radak, Zsolt

    2014-01-01

    Trainability is important in elite sport and in recreational physical activity and the wide range for response to training is largely dependent on genotype. In this study, we compare a newly developed rat model system selectively bred for low and high gain in running distance from aerobic training to test whether genetic segregation for trainability associates with differences in factors associated with mitochondrial biogenesis. Low response trainer (LRT) and high response trainer (HRT) rats from generation 11 of artificial selection were trained five times a week, 30 min per day for three months at 70% VO2max to study the mitochondrial molecular background of trainability. As expected, we found significant differential for the gain in running distance between LRT and HRT groups as a result of training. However, the changes in VO2max, COX 4, redox homeostasis associated markers (ROS), silent mating-type information regulation 2 homolog (SIRT1), NAD+/NADH ratio, proteasome (R2 subunit), and mitochondrial network related proteins such as mitochondrial fission protein 1 (Fis1), and mitochondrial fusion protein (Mfn1) suggest that these markers are not strongly involved in the differences in trainability between LRT and HRT. On the other hand, according to our results, we discovered that differences in basal activity of AMP-activated protein kinase (AMPK), and differential changes in aerobic exercise-induced responses of citrate synthase, carbonylated protein, peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1-α), nuclear respiratory factor 1 (NRF1), mitochondrial transcription factor A (TFAM), and Lon protease limits trainability between these selected lines. From this we conclude that mitochondrial biogenesis associated factors adapt differently to aerobic exercise training in training sensitive and training resistant rats. PMID:24943897

  2. Student Discovers New Pulsar

    NASA Astrophysics Data System (ADS)

    2010-01-01

    A West Virginia high-school student has discovered a new pulsar, using data from the giant Robert C. Byrd Green Bank Telescope (GBT). Shay Bloxton, 15, a participant in a project in which students analyze data from the radio telescope, spotted evidence of the pulsar on October 15. Bloxton, along with NRAO astronomers observed the object again one month later. The new observation confirmed that the object is a pulsar, a rotating, superdense neutron star. Bloxton is a sophomore at Nicholas County High School in Summersville, West Virginia. "I was very excited when I found out I had actually made a discovery," Bloxton said. She went to Green Bank in November to participate in the follow-up observation. She termed that visit "a great experience." "It also helped me learn a lot about how observations with the GBT are actually done," she added. The project in which she participated, called the Pulsar Search Collaboratory (PSC), is a joint project of the National Radio Astronomy Observatory (NRAO) and West Virginia University, funded by a grant from the National Science Foundation. Pulsars are known for their lighthouse-like beams of radio waves that sweep through space as the neutron star rotates, creating a pulse as the beam sweeps by the Earth. First discovered in 1967, pulsars serve as valuable natural "laboratories" for physicists studying exotic states of matter, quantum mechanics and General Relativity. The GBT, dedicated in 2000, has become one of the world's leading tools for discovering and studying pulsars. The PSC, led by NRAO Education Officer Sue Ann Heatherly and Project Director Rachel Rosen, includes training for teachers and student leaders, and provides parcels of data from the GBT to student teams. The project involves teachers and students in helping astronomers analyze data from 1500 hours of observing with the GBT. The 120 terabytes of data were produced by 70,000 individual pointings of the giant, 17-million-pound telescope. Some 300 hours of the

  3. Discovering the Expanding Universe

    NASA Astrophysics Data System (ADS)

    Nussbaumer, Harry; Bieri, Lydia; Sandage, Foreword by Allan

    2009-03-01

    Acknowledgments; Foreword; 1. Introduction; 2. Cosmological concepts at the end of the Middle Ages; 3. Nebulae as a new astronomical phenomenon; 4. On the construction of the Heavens; 5. Island universes turn into astronomical facts: a universe of galaxies; 6. The early cosmology of Einstein and de Sitter; 7. The dynamical universe of Friedmann; 8. Redshifts: how to reconcile Slipher and de Sitter?; 9. Lemaître discovers the expanding universe; 10. Hubble's contribution of 1929; 11. The breakthrough for the expanding universe; 12. Hubble's anger about de Sitter; 13. Robertson and Tolman join the game; 14. The Einstein-de Sitter universe; 15. Are Sun and Earth older than the universe?; 16. In search of alternative tracks; 17. The seed for the Big Bang; 18. Summary and Postscript; Appendix; References; Index.

  4. Recently Discovered Pulsars and Unidentified Egret Sources

    NASA Astrophysics Data System (ADS)

    Torres, Diego F.; Butt, Yousaf M.; Camilo, Fernando

    2001-10-01

    We present a correlative study between all unidentified EGRET sources at low Galactic latitudes and the newly discovered pulsars in the released portion of the Parkes multibeam radio survey. We note 14 positional coincidences: eight of these are ``Vela-like'' pulsars with relatively small periods, small characteristic ages, and high spin-down luminosities. Three of these coincidences have been investigated by D'Amico et al. and Camilo et al. Among the others, we argue that PSR J1015-5719 may plausibly generate part of the high-energy radiation observed from 3EG J1014-5705. Three additional interesting cases are 3EG J1410-6147, either of PSRs J1412-6145 or J1413-6141 if the pulsars are at the estimated distance of the coincident SNR G312.4-0.4, and 3EG J1639-4702/PSR J1637-4642. The remaining positional coincidences between the EGRET sources and the newly discovered pulsars are almost certainly spurious.

  5. Vocal Problems among Aerobic Instructors and Aerobic Participants.

    ERIC Educational Resources Information Center

    Heidel, Sandra E.; Torgerson, John K.

    1993-01-01

    Comparison of vocal problems of 50 female aerobic instructors and 50 female aerobic participants by means of questionnaires found that aerobic instructors generally experienced more hoarseness and episodes of voice loss during and after instructing and exhibited a significantly higher prevalence of nodules. (Author/DB)

  6. Fortuitously discovered liver lesions

    PubMed Central

    Dietrich, Christoph F; Sharma, Malay; Gibson, Robert N; Schreiber-Dietrich, Dagmar; Jenssen, Christian

    2013-01-01

    The fortuitously discovered liver lesion is a common problem. Consensus might be expected in terms of its work-up, and yet there is none. This stems in part from the fact that there is no preventive campaign involving the early detection of liver tumors other than for patients with known liver cirrhosis and oncological patients. The work-up (detection and differential diagnosis) of liver tumors comprises theoretical considerations, history, physical examination, laboratory tests, standard ultrasound, Doppler ultrasound techniques, contrast-enhanced ultrasound (CEUS), computed tomography and magnetic resonance imaging, as well as image-guided biopsy. CEUS techniques have proved to be the most pertinent method; these techniques became part of the clinical routine about 10 years ago in Europe and Asia and are used for a variety of indications in daily clinical practice. CEUS is in many cases the first and also decisive technical intervention for detecting and characterizing liver tumors. This development is reflected in many CEUS guidelines, e.g., in the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) guidelines 2004, 2008 and 2012 as well as the recently published World Federation for Ultrasound in Medicine and Biology-EFSUMB guidelines 2012. This article sets out considerations for making a structured work-up of incidental liver tumors feasible. PMID:23745019

  7. Dance--Aerobic and Anaerobic.

    ERIC Educational Resources Information Center

    Cohen, Arlette

    1984-01-01

    This article defines and explains aerobic exercise and its effects on the cardiovascular system. Various studies on dancers are cited indicating that dance is an anaerobic activity with some small degree of aerobic benefit. (DF)

  8. Dance--Aerobic and Anaerobic.

    ERIC Educational Resources Information Center

    Cohen, Arlette

    1984-01-01

    This article defines and explains aerobic exercise and its effects on the cardiovascular system. Various studies on dancers are cited indicating that dance is an anaerobic activity with some small degree of aerobic benefit. (DF)

  9. Implementation of Aerobic Programs.

    ERIC Educational Resources Information Center

    American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD).

    This information is intended for health professionals interested in implementing aerobic exercise programs in public schools, institutions of higher learning, and business and industry workplaces. The papers are divided into three general sections. The introductory section presents a basis for adhering to a health fitness lifestyle, using…

  10. Chandra Discovers Cosmic Cannonball

    NASA Astrophysics Data System (ADS)

    2007-11-01

    One of the fastest moving stars ever seen has been discovered with NASA's Chandra X-ray Observatory. This cosmic cannonball is challenging theories to explain its blistering speed. Astronomers used Chandra to observe a neutron star, known as RX J0822-4300, over a period of about five years. During that span, three Chandra observations clearly show the neutron star moving away from the center of the Puppis A supernova remnant. This remnant is the stellar debris field created during the same explosion in which the neutron star was created about 3700 years ago. Chandra X-ray Image of RX J0822-4300 in Puppis A Chandra X-ray Image of RX J0822-4300 in Puppis A By combining how far it has moved across the sky with its distance from Earth, astronomers determined the neutron star is moving at over 3 million miles per hour. At this rate, RX J0822-4300 is destined to escape from the Milky Way after millions of years, even though it has only traveled about 20 light years so far. "This star is moving at 3 million miles an hour, but it's so far away that the apparent motion we see in five years is less than the height of the numerals in the date on a penny, seen from the length of a football field," said Frank Winkler of Middlebury College in Vermont. "It's remarkable, and a real testament to the power of Chandra, that such a tiny motion can be measured." Labeled Image of RX J0822-4300 in Puppis A Labeled Image of RX J0822-4300 in Puppis A "Just after it was born, this neutron star got a one-way ticket out of the Galaxy," said co-author Robert Petre of NASA's Goddard Space Flight Center in Greenbelt, Md. "Astronomers have seen other stars being flung out of the Milky Way, but few as fast as this." So-called hypervelocity stars have been previously discovered shooting out of the Milky Way with speeds around one million miles per hour. One key difference between RX J0822-4300 and these other reported galactic escapees is the source of their speed. The hypervelocity stars are

  11. Aerobic Dance in Public Schools.

    ERIC Educational Resources Information Center

    Chiles, Barbara Ann; Moore, Suzanne

    1981-01-01

    Aerobic dance offers a challenging workout in a social atmosphere. Though some physical education instructors tend to exclude dance units from the curriculum, most could teach aerobic dance if they had a basic knowledge of aerobic routines. The outline for a unit to be used in the class is presented. (JN)

  12. Lightest exoplanet yet discovered

    NASA Astrophysics Data System (ADS)

    2009-04-01

    Well-known exoplanet researcher Michel Mayor today announced the discovery of the lightest exoplanet found so far. The planet, "e", in the famous system Gliese 581, is only about twice the mass of our Earth. The team also refined the orbit of the planet Gliese 581 d, first discovered in 2007, placing it well within the habitable zone, where liquid water oceans could exist. These amazing discoveries are the outcome of more than four years of observations using the most successful low-mass-exoplanet hunter in the world, the HARPS spectrograph attached to the 3.6-metre ESO telescope at La Silla, Chile. ESO PR Photo 15a/09 Artist's impression of Gliese 581 e ESO PR Photo 15b/09 A planet in the habitable zone ESO PR Video 15a/09 ESOcast 6 ESO PR Video 15b/09 VNR A-roll ESO PR Video 15c/09 Zoom-in on Gliese 581 e ESO PR Video 15d/09 Artist's impression of Gliese 581 e ESO PR Video 15e/09 Artist's impression of Gliese 581 d ESO PR Video 15f/09 Artist's impression of Gliese 581 system ESO PR Video 15g/09 The radial velocity method ESO PR Video 15h/09 Statement in English ESO PR Video 15i/09 Statement in French ESO PR Video 15j/09 La Silla Observatory "The holy grail of current exoplanet research is the detection of a rocky, Earth-like planet in the ‘habitable zone' -- a region around the host star with the right conditions for water to be liquid on a planet's surface", says Michel Mayor from the Geneva Observatory, who led the European team to this stunning breakthrough. Planet Gliese 581 e orbits its host star - located only 20.5 light-years away in the constellation Libra ("the Scales") -- in just 3.15 days. "With only 1.9 Earth-masses, it is the least massive exoplanet ever detected and is, very likely, a rocky planet", says co-author Xavier Bonfils from Grenoble Observatory. Being so close to its host star, the planet is not in the habitable zone. But another planet in this system appears to be. From previous observations -- also obtained with the HARPS spectrograph

  13. Digimarc Discover on Google Glass

    NASA Astrophysics Data System (ADS)

    Rogers, Eliot; Rodriguez, Tony; Lord, John; Alattar, Adnan

    2015-03-01

    This paper reports on the implementation of the Digimarc® Discover platform on Google Glass, enabling the reading of a watermark embedded in a printed material or audio. The embedded watermark typically contains a unique code that identifies the containing media or object and a synchronization signal that allows the watermark to be read robustly. The Digimarc Discover smartphone application can read the watermark from a small portion of printed image presented at any orientation or reasonable distance. Likewise, Discover can read the recently introduced Digimarc Barcode to identify and manage consumer packaged goods in the retail channel. The Digimarc Barcode has several advantages over the traditional barcode and is expected to save the retail industry millions of dollars when deployed at scale. Discover can also read an audio watermark from ambient audio captured using a microphone. The Digimarc Discover platform has been widely deployed on the iPad, iPhone and many Android-based devices, but it has not yet been implemented on a head-worn wearable device, such as Google Glass. Implementing Discover on Google Glass is a challenging task due to the current hardware and software limitations of the device. This paper identifies the challenges encountered in porting Discover to the Google Glass and reports on the solutions created to deliver a prototype implementation.

  14. Aerobic landfill bioreactor

    SciTech Connect

    Hudgins, M.P.; Bessette, B.J.; March, J.; McComb, S.T.

    2000-02-15

    The present invention includes a method of decomposing municipal solid waste (MSW) within a landfill by converting the landfill to aerobic degradation in the following manner: (1) injecting air via the landfill leachate collection system (2) injecting air via vertical air injection wells installed within the waste mass; (3) applying leachate to the waste mass using a pressurized drip irrigation system; (4) allowing landfill gases to vent; and (5) adjusting air injection and recirculated leachate to achieve a 40% to 60% moisture level and a temperature between 120 F and 140 F in steady state.

  15. Aerobic landfill bioreactor

    DOEpatents

    Hudgins, Mark P; Bessette, Bernard J; March, John C; McComb, Scott T.

    2002-01-01

    The present invention includes a system of decomposing municipal solid waste (MSW) within a landfill by converting the landfill to aerobic degradation in the following manner: (1) injecting air via the landfill leachate collection system (2) injecting air via vertical air injection wells installed within the waste mass; (3) applying leachate to the waste mass using a pressurized drip irrigation system; (4) allowing landfill gases to vent; and (5) adjusting air injection and recirculated leachate to achieve a 40% to 60% moisture level and a temperature between 120.degree. F. and 140.degree. F. in steady state.

  16. Aerobic landfill bioreactor

    DOEpatents

    Hudgins, Mark P; Bessette, Bernard J; March, John; McComb, Scott T.

    2000-01-01

    The present invention includes a method of decomposing municipal solid waste (MSW) within a landfill by converting the landfill to aerobic degradation in the following manner: (1) injecting air via the landfill leachate collection system (2) injecting air via vertical air injection wells installed within the waste mass; (3) applying leachate to the waste mass using a pressurized drip irrigation system; (4) allowing landfill gases to vent; and (5) adjusting air injection and recirculated leachate to achieve a 40% to 60% moisture level and a temperature between 120.degree. F. and 140.degree. F. in steady state.

  17. Exercise, Animal Aerobics, and Interpretation?

    ERIC Educational Resources Information Center

    Oliver, Valerie

    1996-01-01

    Describes an aerobic activity set to music for children that mimics animal movements. Example exercises include walking like a penguin or jumping like a cricket. Stresses basic aerobic principles and designing the program at the level of children's motor skills. Benefits include reaching people who normally don't visit nature centers, and bridging…

  18. Exercise, Animal Aerobics, and Interpretation?

    ERIC Educational Resources Information Center

    Oliver, Valerie

    1996-01-01

    Describes an aerobic activity set to music for children that mimics animal movements. Example exercises include walking like a penguin or jumping like a cricket. Stresses basic aerobic principles and designing the program at the level of children's motor skills. Benefits include reaching people who normally don't visit nature centers, and bridging…

  19. Diagnostic and therapeutic advancements for aerobic vaginitis.

    PubMed

    Han, Cha; Wu, Wenjuan; Fan, Aiping; Wang, Yingmei; Zhang, Huiying; Chu, Zanjun; Wang, Chen; Xue, Fengxia

    2015-02-01

    Aerobic vaginitis (AV) is a newly defined clinical entity that is distinct from candidiasis, trichomoniasis and bacterial vaginosis (BV). Because of the poor recognition of AV, this condition can lead to treatment failures and is associated with severe complications, such as pelvic inflammatory disease, infertility, preterm birth and foetal infections. This review describes the diagnosis and treatment of AV and the relationship between AV and pregnancy. The characteristics of AV include severely depressed levels of lactobacilli, increased levels of aerobic bacteria and an inflamed vagina. The diagnosis is made by microscopy on wet mounts of fresh vaginal fluid, and some distinct clinical features are recognized. Vaginal suppositories that contain kanamycin or clindamycin have shown curative effects in nonpregnant women. Additionally, the application of topical probiotics can restore the vaginal flora and reduce the recurrence of AV. Clindamycin vaginal suppositories and probiotics may be a better choice for gravida with AV than metronidazole. AV requires prompt attention, and the early diagnosis and treatment of AV during pregnancy significantly improves perinatal outcomes. Further research is needed to define the pathogenesis, diagnostic criteria and standard treatment guidelines for AV.

  20. Discovering biomedical relations utilizing the World-wide Web.

    PubMed

    Mukherjea, Sougata; Sahay, Saurav

    2006-01-01

    To crate a Semantic Web for Life Sciences discovering relations between biomedical entities is essential. Journals and conference proceedings represent the dominant mechanisms of reporting newly discovered biomedical interactions. The unstructured nature of such publications makes it difficult to utilize data mining or knowledge discovery techniques to automatically incorporate knowledge from these publications into the ontologies. On the other hand, since biomedical information is growing explosively, it is difficult to have human curators manually extract all the information from literature. In this paper we present techniques to automatically discover biomedical relations from the World-wide Web. For this purpose we retrieve relevant information from Web Search engines using various lexico-syntactic patterns as queries. Experiments are presented to show the usefulness of our techniques.

  1. Aerobic Biodegradation of Trichloroethylene.

    DTIC Science & Technology

    1987-07-01

    the meta ring-fission product , the supernatant solution of phenol- induced restTW cells incubated with catechol and 3-methylcatechol was examined ...into C02 and unidentified nonvolatile products . Phenol, 41 toiin- andq-cresol were found to replace the site water requirement for TCE metabolism...undertaken in an effort to discover microorganisms capable of degrading TCE to innocuous products . Isolation of a microorganism with TCE-degrading ability

  2. Families Discover the Outdoors Together.

    ERIC Educational Resources Information Center

    Parent, Polly

    1980-01-01

    An idea for hands-on activities for families to use in discovering the outdoors together when visiting parks is described. Family packs contain discovery and natural history cards, thermometers, magnifiers, insect boxes, photographs of animals and plants, a pencil, and a feedback form. (SA)

  3. DISCOVER: A Computerized Careers Curriculum.

    ERIC Educational Resources Information Center

    Rayman, Jack R.

    Liberal arts campuses are feeling a need to provide better career education services for their undergraduate students. The DISCOVER Foundation has developed a comprehensive computerized career guidance system for grades 7 through 12 which not only provides career information, but also performs such tasks as teaching students decision-making skills…

  4. DISCOVER-AQ Featured Articles

    Atmospheric Science Data Center

    2017-01-31

    ...     Not Your Average Video Traffic Report : Earth Matters Blogs  - DISCOVER-AQ planes have been flying over roadways, ... of air quality during “rush hour” and throughout the day. News Roundup: Arctic Ice, Spacesuit Satellites and More : Earth ...

  5. Families Discover the Outdoors Together.

    ERIC Educational Resources Information Center

    Parent, Polly

    1980-01-01

    An idea for hands-on activities for families to use in discovering the outdoors together when visiting parks is described. Family packs contain discovery and natural history cards, thermometers, magnifiers, insect boxes, photographs of animals and plants, a pencil, and a feedback form. (SA)

  6. Quantifying factors limiting aerobic degradation during aerobic bioreactor landfilling.

    PubMed

    Yazdani, Ramin; Mostafid, M Erfan; Han, Byunghyun; Imhoff, Paul T; Chiu, Pei; Augenstein, Don; Kayhanian, Masoud; Tchobanoglous, George

    2010-08-15

    A bioreactor landfill cell at Yolo County, California was operated aerobically for six months to quantify the extent of aerobic degradation and mechanisms limiting aerobic activity during air injection and liquid addition. The portion of the solid waste degraded anaerobically was estimated and tracked through time. From an analysis of in situ aerobic respiration and gas tracer data, it was found that a large fraction of the gas-filled pore space was in immobile zones where it was difficult to maintain aerobic conditions, even at relatively moderate landfill cell-average moisture contents of 33-36%. Even with the intentional injection of air, anaerobic activity was never less than 13%, and sometimes exceeded 65%. Analyses of gas tracer and respiration data were used to quantify rates of respiration and rates of mass transfer to immobile gas zones. The similarity of these rates indicated that waste degradation was influenced significantly by rates of oxygen transfer to immobile gas zones, which comprised 32-92% of the gas-filled pore space. Gas tracer tests might be useful for estimating the size of the mobile/immobile gas zones, rates of mass transfer between these regions, and the difficulty of degrading waste aerobically in particular waste bodies.

  7. DISCOVER AQ Research Plane Arrives

    NASA Image and Video Library

    2011-06-28

    James Crawford, principal investigator and scientist based at NASA’s Langley Research Center in Hampton, Va., talks about the DISCOVER-AQ project on board the P-3B NASA research aircraft at Baltimore/Washington International Thurgood Marshall Airport, Tuesday, June 28, 2011, in Baltimore, Md. The aircraft is part of a month-long field campaign designed to improve satellite measurements of air pollution. The name of the experiment -- Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER -- AQ) -- is a mouthful, but its purpose is simple. Come July, the aircraft will be flying spirals over six ground stations in Maryland. Photo Credit: (NASA/Paul E. Alers)

  8. DISCOVER AQ Research Plane Arrives

    NASA Image and Video Library

    2011-06-28

    WFF Pilots Mike Singer, left, and Shane Dover stand in front of the 117-foot P-3B NASA research aircraft on the tarmac at Baltimore/Washington International Thurgood Marshall Airport, Tuesday, June 28, 2011, in Baltimore, Md. The aircraft is part of a month-long field campaign designed to improve satellite measurements of air pollution. The name of the experiment -- Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER -- AQ) -- is a mouthful, but its purpose is simple. Come July, the aircraft will be flying spirals over six ground stations in Maryland. Photo Credit: (NASA/Paul E. Alers)

  9. DISCOVER AQ Research Plane Arrives

    NASA Image and Video Library

    2011-06-28

    A 117-foot P-3B NASA research aircraft is seen on the tarmac at Baltimore/Washington International Thurgood Marshall Airport, Tuesday, June 28, 2011, in Baltimore, Md. The aircraft is part of a month-long field campaign designed to improve satellite measurements of air pollution. The name of the experiment -- Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER -- AQ) -- is a mouthful, but its purpose is simple. Come July, the aircraft will be flying spirals over six ground stations in Maryland. Photo Credit: (NASA/Paul E. Alers)

  10. DISCOVER AQ Research Plane Arrives

    NASA Image and Video Library

    2011-06-28

    Pilots Shane Dover, left, and Mike Singer are seen on the flight deck of the P-3B NASA research aircraft at Baltimore/Washington International Thurgood Marshall Airport, Tuesday, June 28, 2011, in Baltimore, Md. The aircraft is part of a month-long field campaign designed to improve satellite measurements of air pollution. The name of the experiment -- Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER -- AQ) -- is a mouthful, but its purpose is simple. Come July, the aircraft will be flying spirals over six ground stations in Maryland. Photo Credit: (NASA/Paul E. Alers)

  11. DISCOVER AQ Research Plane Arrives

    NASA Image and Video Library

    2011-06-28

    An unidentified researcher works aboard the P-3B NASA research aircraft at Baltimore/Washington International Thurgood Marshall Airport, Tuesday, June 28, 2011, in Baltimore, Md. The aircraft is part of a month-long field campaign designed to improve satellite measurements of air pollution. The name of the experiment -- Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER -- AQ) -- is a mouthful, but its purpose is simple. Come July, the aircraft will be flying spirals over six ground stations in Maryland. Photo Credit: (NASA/Paul E. Alers)

  12. Rapid OT discovered by MASTER

    NASA Astrophysics Data System (ADS)

    Balanutsa, P.; Gorbovskoy, E.; Lipunov, V.; Denisenko, D.; Tiurina, N.; Kornilov, V.; Belinski, A.; Shatskiy, N.; Chazov, V.; Kuznetsov, A.; Zimnukhov, D.; Krushinsky, V.; Zalozhnih, I.; Popov, A.; Bourdanov, A.; Punanova, A.; Ivanov, K.; Yazev, S.; Budnev, N.; Konstantinov, E.; Chuvalaev, O.; Poleshchuk, V.; Gress, O.; Parkhomenko, A.; Tlatov, A.; Dormidontov, D.; Senik, V.; Yurkov, V.; Sergienko, Y.; Varda, D.; Sinyakov, E.; Shumkov, V.; Shurpakov, S.; Levato, H.; Saffe, C.; Mallamaci, C.; Lopez, C.; Podest, F.

    2012-09-01

    OT MASTER J005552.55+261100.8 discovery MASTER-Amur auto-detection system discovered OT source at (RA, Dec) = 00h 55m 52.55s +26d 11m 00.8s on 2012-08-30.77359 UT by two tube simultaneously during 3 min exposition. The OT unfiltered magnitude is 14.2m (limit 18.0m). There is no minor planet at this place. There is no known satellite around 4 degrees at this time. There is one non star object NBKY021338 (jmag~ 22.3) in the Guide Star Catalog with 3.6 arcsec offset.

  13. Discover an Asteroid Using SDSS

    NASA Astrophysics Data System (ADS)

    Ramseyer, Elizabeth A.

    2006-12-01

    Every Fall, the Apache Point Observatory repeatedly images the skies near declination 0 degrees in a quest to see first light from distant supernovae. The Sloan Digital Sky Survey (SDSS) uses the data from these images to map the Universe. These data are made available on the internet for use by the public. While analyzing these images, we discovered the presence of a transient light source that subsequent analysis showed our ?mystery object? to be an asteroid. We present here the details of the analysis that allowed us to determine the identity of our ?mystery object.? Learn how you can access the SDSS database and make your own discovery!

  14. Digital Discover of Ephemeral Ponds

    DTIC Science & Technology

    2012-08-01

    ER D C/ CE RL T R - 12 -2 1 Center Directed Research Program Digital Discover of Ephemeral Ponds En gi ne er R es ea rc h an d D ev el...r.mapcalc formula : r.terraflow lidar_elev filled=elev_filled \\ accum=elev_accum memory=2000 \\ dir=elev_dir swater=elev_sink tci =elev_tci...J. D., M. Shapiro, W. D. Goran, and D. P. Gerdes. 1992. Geographic Resources Analysis Support System (GRASS) Version 4.0 User’s Reference Manual . N

  15. Newly Deployed Sojourner Rover

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This 8-image mosaic was acquired during the late afternoon (near 5pm LST, note the long shadows) on Sol 2 as part of the predeploy 'insurance panorama' and shows the newly deployed rover sitting on the Martian surface. This color image was generated from images acquired at 530,600, and 750 nm. The insurance panorama was designed as 'insurance' against camera failure upon deployment. Had the camera failed, the losslessly-compressed, multispectral insurance panorama would have been the main source of image data from the IMP.

    However, the camera deployment was successful, leaving the insurance panorama to be downlinked to Earth several weeks later. Ironically enough, the insurance panorama contains some of the best quality image data because of the lossless data compression and relatively dust-free state of the camera and associated lander/rover hardware on Sol 2.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal investigator.

  16. Newly Deployed Sojourner Rover

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This 8-image mosaic was acquired during the late afternoon (near 5pm LST, note the long shadows) on Sol 2 as part of the predeploy 'insurance panorama' and shows the newly deployed rover sitting on the Martian surface. This color image was generated from images acquired at 530,600, and 750 nm. The insurance panorama was designed as 'insurance' against camera failure upon deployment. Had the camera failed, the losslessly-compressed, multispectral insurance panorama would have been the main source of image data from the IMP.

    However, the camera deployment was successful, leaving the insurance panorama to be downlinked to Earth several weeks later. Ironically enough, the insurance panorama contains some of the best quality image data because of the lossless data compression and relatively dust-free state of the camera and associated lander/rover hardware on Sol 2.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal investigator.

  17. Beta-rhizobia from Mimosa pigra, a newly discovered invasive plant in Taiwan.

    PubMed

    Chen, Wen-Ming; James, Euan K; Chou, Jui-Hsing; Sheu, Shih-Yi; Yang, Sheng-Zehn; Sprent, Janet I

    2005-12-01

    A total of 191 rhizobial isolates from the root nodules of three geographically separate populations of the invasive plant Mimosa pigra in Taiwan were examined using amplified rDNA restriction analysis, 16S rDNA sequences, protein profiles and ELISA. Of these, 96% were identified as Burkholderia and 4% as Cupriavidus taiwanensis. The symbiosis-essential genes nodA and nifH were present in two strains of Burkholderia (PAS44 and PTK47), and in one of C. taiwanensis (PAS15). All three could nodulate M. pigra. Light and electron microscopy studies with a green fluorescent protein transconjugant variant of strain PAS44 showed the presence of fluorescent bacteroids in M. pigra nodules. These bacteroids expressed the nifH protein, hence this is the first confirmation that Burkholderia is a genuine symbiont of legume nodules. The predominance of Burkholderia in Taiwanese M. pigra suggests that this species may have brought its symbionts from its native South America, rather than entering into association with the Taiwanese Mimosa symbiont C. taiwanensis which so successfully nodulates Mimosa pudica and Mimosa diplotricha.

  18. Verification of the anatomy and newly discovered histology of the G-spot complex.

    PubMed

    Ostrzenski, A; Krajewski, P; Ganjei-Azar, P; Wasiutynski, A J; Scheinberg, M N; Tarka, S; Fudalej, M

    2014-10-01

    To expand the anatomical investigations of the G-spot and to assess the G-spot's characteristic histological and immunohistochemical features. An observational study. International multicentre. Eight consecutive fresh human female cadavers. Anterior vaginal wall dissections were executed and G-spot microdissections were performed. All specimens were stained with haematoxylin and eosin (H&E). The tissues of two women were selected at random for immunohistochemical staining. The primary outcome measure was to document the anatomy of the G-spot. The secondary outcome measures were to identify the histology of the G-spot and to determine whether histological samples stained with H&E are sufficient to identify the G-spot. The anatomical existence of the G-spot was identified in all women and was in a diagonal plane. In seven (87.5%) and one (12.5%) of the women the G-spot complex was found on the left or right side, respectively. The G-spot was intimately fused with vessels, creating a complex. A large tangled vein-like vascular structure resembled an arteriovenous malformation and there were a few smaller feeding arteries. A band-like structure protruded from the tail of the G-spot. The size of the G-spot varied. Histologically, the G-spot was determined as a neurovascular complex structure. The neural component contained abundant peripheral nerve bundles and a nerve ganglion. The vascular component comprised large vein-like vessels and smaller feeding arteries. Circular and longitudinal muscles covered the G-complex. The anatomy of the G-spot complex was confirmed. The histology of the G-spot presents as neurovascular tissues with a nerve ganglion. H&E staining is sufficient for the identification of the G-spot complex. © 2014 Royal College of Obstetricians and Gynaecologists.

  19. ACS Photometry of Newly Discovered Globular Clusters in the Outer Halo of M31

    NASA Astrophysics Data System (ADS)

    Mackey, A. D.; Huxor, A.; Ferguson, A. M. N.; Tanvir, N. R.; Irwin, M.; Ibata, R.; Bridges, T.; Johnson, R. A.; Lewis, G.

    2007-02-01

    We report the first results from deep ACS imaging of 10 classical globular clusters in the far outer regions (15 kpc<~Rp<~100 kpc) of M31. Eight of the clusters, including two of the most remote M31 globular clusters presently known, are described for the first time. Our F606W, F814W color-magnitude diagrams extend ~3 mag below the horizontal branch and clearly demonstrate that the majority of these objects are old (>~10 Gyr), metal-poor clusters. Five have [Fe/H] ~ -2.1, while an additional four have -1.9 <~ [Fe/H] <~ -1.5. The remaining object is more metal-rich, with [Fe/H] ~ -0.70. Several clusters exhibit the second-parameter effect. Using aperture photometry, we estimate integrated luminosities and structural parameters for all clusters. Many, including all four clusters with projected radii greater than 45 kpc, are compact and very luminous, with -8.9 <~ MV <~ -8.3. These four outermost clusters are thus quite unlike their Milky Way counterparts, which are typically diffuse, subluminous (-6.0 <~ MV <~ -4.7), and more metal-rich (-1.8 <~ [Fe/H] <~ -1.3). Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. These observations are associated with program 10394.

  20. A Newly Discovered Supernova Remnant and MSH 11-62 and 3C58

    NASA Technical Reports Server (NTRS)

    Slane, Patrick O.

    2000-01-01

    CTA 1 is a center-filled supernova remnant (SNR) whose morphology and spectrum indicate the presence of a central pulsar, a synchrotron nebula, and a thermal component associated with the expansion of the blast wave into the interstellar medium. The centrally bright emission surrounds the position of a faint point source of X-rays observed with the ROSAT Position Sensitive Proportional Counter (PSPC). Here we report on Advanced Spacecraft for Cosmology Astrophysics (ASCA) observations that confirm the nonthermal nature of the diffuse emission from the central regions of the remnant. We also present evidence for weak thermal emission that appears to increase in strength toward the outer boundary of the SNR. Thus, CTA 1 appears to be an X-ray composite remnant. Both the aftermath of the explosive supernova event and the energetic compact core are observable.

  1. Morphometrics parallel genetics in a newly discovered and endangered taxon of Galápagos tortoise.

    PubMed

    Chiari, Ylenia; Hyseni, Chaz; Fritts, Tom H; Glaberman, Scott; Marquez, Cruz; Gibbs, James P; Claude, Julien; Caccone, Adalgisa

    2009-07-17

    Galápagos tortoises represent the only surviving lineage of giant tortoises that exhibit two different types of shell morphology. The taxonomy of Galápagos tortoises was initially based mainly on diagnostic morphological characters of the shell, but has been clarified by molecular studies indicating that most islands harbor monophyletic lineages, with the exception of Isabela and Santa Cruz. On Santa Cruz there is strong genetic differentiation between the two tortoise populations (Cerro Fatal and La Reserva) exhibiting domed shell morphology. Here we integrate nuclear microsatellite and mitochondrial data with statistical analyses of shell shape morphology to evaluate whether the genetic distinction and variability of the two domed tortoise populations is paralleled by differences in shell shape. Based on our results, morphometric analyses support the genetic distinction of the two populations and also reveal that the level of genetic variation is associated with morphological shell shape variation in both populations. The Cerro Fatal population possesses lower levels of morphological and genetic variation compared to the La Reserva population. Because the turtle shell is a complex heritable trait, our results suggest that, for the Cerro Fatal population, non-neutral loci have probably experienced a parallel decrease in variability as that observed for the genetic data.

  2. Newly discovered natural hosts of tomato chlorosis virus in Costa Rica

    USDA-ARS?s Scientific Manuscript database

    Tomato chlorosis virus (ToCV) is an emerging whitefly-transmitted crinivirus. ToCV was detected in field-grown and greenhouse tomato (Solanum lycopersicum L.) plants in Costa Rica in 2007, causing symptoms of severe yellowing and foliar chlorosis. To identify alternative hosts that may serve as viru...

  3. The Role of Newly Discovered Exotoxin (S Toxin) in Pseudomonas aeruginosa Infections

    DTIC Science & Technology

    1980-08-01

    similar rates of cell division (average doubling time in hours was 13.2 and 12.5, respectively). Karyotypic analysis showed that both the P)BHK and...titers were not determined, the amount of precipitating antibody estimated from immunodiffusion analysis ranged from 20 ugm/ml to 500 U gm/ml. Sera

  4. A description of the Omo I postcranial skeleton, including newly discovered fossils.

    PubMed

    Pearson, Osbjorn M; Royer, Danielle F; Grine, Frederick E; Fleagle, John G

    2008-09-01

    Recent fieldwork in the Kibish Formation has expanded our knowledge of the geological, archaeological, and faunal context of the Omo I skeleton, the earliest known anatomically modern human. In the course of this fieldwork, several additional fragments of the skeleton were recovered: a middle manual phalanx, a distal manual phalanx, a right talus, a large and a small fragment of the left os coxae, a portion of the distal diaphysis of the right femur that conjoins with the distal epiphysis recovered in 1967, and a costal fragment. Some researchers have described the original postcranial fragments of Omo I as anatomically modern but have noted that a variety of aspects of the specimen's morphology depart from the usual anatomy of many recent populations. Reanalysis confirms this conclusion. Some of the unusual features in Omo I--a medially facing radial tuberosity, a laterally flaring facet on the talus for the lateral malleolus, and reduced dorsovolar curvature of the base of metacarpal I--are shared with Neandertals, some early modern humans from Skhul and Qafzeh, and some individuals from the European Gravettian, raising the possibility that Eurasian early modern humans inherited these features from an African predecessor rather than Neandertals. The fragment of the os coxae does not unambiguously diagnose Omo I's sex: the greater sciatic notch is intermediate in form, the acetabulum is large (male?), and a preauricular sulcus is present (female?). The preserved portion of the left humerus suggests that Omo I was quite tall, perhaps 178-182 cm, but the first metatarsal suggests a shorter stature of 162-173 cm. The morphology of the auricular surface of the os coxae suggests a young adult age.

  5. SDSS J102111.02+491330.4: A Newly discovered gravitationally lensed quasar

    SciTech Connect

    Pindor, Bart; Eisenstein, Daniel J.; Gregg, Michael D.; Becker, Robert H.; Inada, Naohisa; Oguri, Masamune; Hall, Patrick B.; Johnston, David E.; Richards, Gordon T.; Schneider, Donald P.; Turner, Edwin L.; Brasi, Guido; Hinz, Philip M.; Kenworthy, Matthew A.; Miller, Doug; Barentine, J.C.; Brewington, Howard J.; Brinkmann, J.; Harvanek, Michael; Kleinman, S.J.; Krzesinski, Jurek; /Toronto U., Astron. Dept. /Arizona U., Astron. Dept. - Steward Observ. /UC, Davis /LLNL, Livermore /Tokyo U., Inst. Astron. /Tokyo U. /Princeton U. Observ. /York U., Canada /Penn State U., Astron. Astrophys. /Apache Point Observ. /Mt. Suhora Observ., Cracow /Fermilab /Chicago U., Astron. Astrophys. Ctr.

    2005-09-01

    We report follow-up observations of two gravitational lens candidates identified in the Sloan Digital Sky Survey (SDSS) dataset. We have confirmed that SDSS J102111.02+491330.4 is a previously unknown gravitationally lensed quasar. This lens system exhibits two images of a z = 1.72 quasar, with an image separation of 1.14'' {+-} 0.04''. Optical and near-IR imaging of the system reveals the presence of the lensing galaxy between the two quasar images. Observations of SDSS J112012.12+671116.0 indicate that it is more likely a binary quasar than a gravitational lens. This system has two quasars at a redshift of z = 1.49, with an angular separation of 1.49'' {+-} 0.02''. However, the two quasars have markedly different SEDs and no lens galaxy is apparent in optical and near-IR images of this system. We also present a list of 31 SDSS lens candidates which follow-up observations have confirmed are not gravitational lenses.

  6. Antibiotic-producing ability by representatives of a newly discovered lineage of actinomycetes.

    PubMed

    Busti, Elena; Monciardini, Paolo; Cavaletti, Linda; Bamonte, Ruggiero; Lazzarini, Ameriga; Sosio, Margherita; Donadio, Stefano

    2006-03-01

    The discovery of new antibiotics and other bioactive microbial metabolites continues to be an important objective in new drug research. Since extensive screening has led to the discovery of thousands of bioactive microbial molecules, new approaches must be taken in order to reduce the probability of rediscovering known compounds. The authors have recently isolated slow-growing acidophiles belonging to the novel genera Catenulispora and Actinospica within the order Actinomycetales. These strains, which likely belong to a new suborder, grow as filamentous mycelia, have a genome size around 8 Mb, and produce antimicrobial activities. In addition, a single strain harbours simultaneously genes encoding type I and type II polyeketide synthases, as well as non-ribosomal peptide synthetases. The metabolite produced by one strain was identified as a previously reported dimeric isochromanequinone. In addition, at least the Catenulispora strains appear globally distributed, since a PCR-specific signal could be detected in a significant fraction of acidic soils from different continents, and similar strains have been independently isolated from an Australian soil (Jospeh et al., Appl Environ Microbiol 69, 7210-7215, 2003). Thus, these previously uncultured actinomycetes share several features with Streptomyces and related antibiotic-producing genera, and represent a promising source of novel antibiotics.

  7. The JH1 Haplotype-a newly discovered marker for infertility in the jersy breed

    USDA-ARS?s Scientific Manuscript database

    The focus on production traits in genetic selection programs with little consideration for traits associated with reproduction has contributed to the decline in reproductive function. Moreover, there is a negative genetic correlation between milk yield and reproduction so that selection for yield ca...

  8. Genome characterisation of the newly discovered avian influenza A H5N7 virus subtype combination.

    PubMed

    Bragstad, K; Jørgensen, P H; Handberg, K J; Fomsgaard, A

    2007-01-01

    In Denmark, in 2003, a previously unknown subtype combination of avian influenza A virus, H5N7 (A/Mallard/Denmark/64650/03), was isolated from a flock of 12,000 mallards. The H5N7 subtype combination might be a reassortant between recent European avian influenza A H5, H7, and a third subtype, possibly an H6. The haemagglutinin and the acidic polymerase genes of the virus were closely related to a low-pathogenic Danish H5N2 virus A/Duck/Denmark/65041/04 (H5N2). The neuraminidase gene and the non-structural gene were most similar to the highly pathogenic A/Chicken/Netherlands/1/03 (H7N7) and the human-fatal A/Netherlands/219/03 (H7N7), respectively. The basic polymerase 1 and 2 genes were phylogenetically equidistant to both A/Duck/Denmark/65047/04 (H5N2) and A/Chicken/Netherlands/1/03 (H7N7). The nucleoprotein and matrix gene had highest nucleotide sequence similarity to the H6 subtypes A/Duck/Hong Kong/3096/99 (H6N2) and A/WDk/ST/1737/2000 (H6N8), respectively. All genes of the H5N7 strain were of avian origin, and no further evidence of pathogenicity to humans has been found.

  9. Newly discovered hydrothermal system on the Alarcón Rise, Mexico

    NASA Astrophysics Data System (ADS)

    Paduan, J. B.; Clague, D. A.; Caress, D. W.; Lundsten, L.; Martin, J. F.; Nieves-Cardoso, C.

    2012-12-01

    The Alarcón Rise lies at the mouth of the Gulf of California, and is the last segment of the East Pacific Rise before the plate boundary redirects into the gulf. As part of MBARI's expedition to the gulf in 2012, the neovolcanic zone of the entire ridge segment was mapped by MBARI's mapping AUV. 110 potential hydrothermal chimneys were identified in the new high resolution maps, and 70 were visited with the ROV Doc Ricketts, after having been sought in vain without the maps on an expedition in 2003. Two active vent fields were found, and have been named Meyibó and Ja sít from local native languages. They lie 2.5km apart at ~2300m depth, and are associated with a large, young sheet flow 1/3 of the way along the ridge from the south, on the most inflated part of the ridge. The southern field, Meyibó, contains 14 active chimneys (confirmed with ROV observations) nestled in grabens of several highly fractured cones surrounded by the sheet flow, and generally aligned with its discontinuous, 8km-long fissure system. The northern field, Ja sít, is a broad cluster of 8 active chimneys (also confirmed) rising above the sheet flow's channel system, more than 150m from the fissure. The chimneys stand as tall as 18 m. The most vigorous vent "black smoke" (mineral-rich fluid) >300°C and others are bathed in "white smoke". The active chimneys are populated with bacterial mat and dense clumps of Riftia pachyptila with tubes as long as 1.5m. Abundant limpets, Bythograea thermydron and galatheid crabs, and the pink vent fish Thermarces cerberus were on and near the giant tube worms. Alvinellid worms were observed at 2 chimneys. Some cracks in nearby lava flows vented clear fluid and were populated with tubeworms or Calyptogena magnifica clams. Several chimneys exhibited signs of waning activity: dead tubeworms were still attached and only a minor portion of the edifice supported bacterial mat and live tubeworms. Inactive chimneys are more numerous (48 were confirmed with ROV observations; 40 more were not visited but are presumed inactive, as turbid bottom waters were only observed in the vicinity of the active vents). Most are almost 10km NE of the Ja sít active field in a ridge-parallel array stretching 2.3km. These were deeper (to 2392m) and associated with older flows. Some had only recently ceased venting, as clam shell fragments and relatively fragile vent orifices were still present. Inactive chimneys are also intermingled with the active chimneys. Some of the recovered samples have abundant chalcopyrite, but most are predominantly zinc and iron sulfide. Inactive chimneys stand tall in the AUV maps but as they are no longer venting, would not be detected by traditional water-column surveys. Elsewhere, however, sulfide-bearing sediments were also recovered, evidence of prior hydrothermal activity that would not be detected in the AUV maps. Features that could be mistaken for sulfide chimneys also appear in the maps, but morphology distinguishes them as lava pillars along margins of collapsed flows, fault blocks, pressure ridges, or steep summits of pillow mounds.

  10. Degradation of Polycyclic Aromatic Hydrocarbons by a Newly Discovered Enteric Bacterium, Leclercia adecarboxylata

    PubMed Central

    Sarma, Priyangshu Manab; Bhattacharya, Dhruva; Krishnan, S.; Lal, Banwari

    2004-01-01

    A bacterial strain, PS4040, capable of degrading polycyclic aromatic hydrocarbons for use as the sole carbon source was isolated from oily-sludge-contaminated soil. The 16S rRNA gene showed 98.8% homology to that of Leclercia adecarboxylata. Comparative molecular typing with the clinical strain of L. adecarboxylata revealed that there were few comigrating and few distinct amplimers among them. PMID:15128584

  11. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

    PubMed Central

    Ahmed, Shahana; Thomas, Gilles; Ghoussaini, Maya; Healey, Catherine S; Humphreys, Manjeet K; Platte, Radka; Morrison, Jonathan; Maranian, Melanie; Pooley, Karen A; Luben, Robert; Eccles, Diana; Evans, D Gareth; Fletcher, Olivia; Johnson, Nichola; Silva, Isabel dos Santos; Peto, Julian; Stratton, Michael R; Rahman, Nazneen; Jacobs, Kevin; Prentice, Ross; Anderson, Garnet L; Rajkovic, Aleksandar; Curb, J David; Ziegler, Regina G; Berg, Christine D; Buys, Saundra S; McCarty, Catherine A; Feigelson, Heather Spencer; Calle, Eugenia E; Thun, Michael J; Diver, W Ryan; Bojesen, Stig; Nordestgaard, Børge G; Flyger, Henrik; Dörk, Thilo; Schürmann, Peter; Hillemanns, Peter; Karstens, Johann H; Bogdanova, Natalia V; Antonenkova, Natalia N; Zalutsky, Iosif V; Bermisheva, Marina; Fedorova, Sardana; Khusnutdinova, Elza; Kang, Daehee; Yoo, Keun-Young; Noh, Dong Young; Ahn, Sei-Hyun; Devilee, Peter; van Asperen, Christi J; Tollenaar, R A E M; Seynaeve, Caroline; Garcia-Closas, Montserrat; Lissowska, Jolanta; Brinton, Louise; Peplonska, Beata; Nevanlinna, Heli; Heikkinen, Tuomas; Aittomäki, Kristiina; Blomqvist, Carl; Hopper, John L; Southey, Melissa C; Smith, Letitia; Spurdle, Amanda B; Schmidt, Marjanka K; Broeks, Annegien; van Hien, Richard R; Cornelissen, Sten; Milne, Roger L; Ribas, Gloria; González-Neira, Anna; Benitez, Javier; Schmutzler, Rita K; Burwinkel, Barbara; Bartram, Claus R; Meindl, Alfons; Brauch, Hiltrud; Justenhoven, Christina; Hamann, Ute; Chang-Claude, Jenny; Hein, Rebecca; Wang-Gohrke, Shan; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kosma, Veli-Matti; Kataja, Vesa; Olson, Janet E; Wang, Xianshu; Fredericksen, Zachary; Giles, Graham G; Severi, Gianluca; Baglietto, Laura; English, Dallas R; Hankinson, Susan E; Cox, David G; Kraft, Peter; Vatten, Lars J; Hveem, Kristian; Kumle, Merethe; Sigurdson, Alice; Doody, Michele; Bhatti, Parveen; Alexander, Bruce H; Hooning, Maartje J; van den Ouweland, Ans M W; Oldenburg, Rogier A; Schutte, Mieke; Hall, Per; Czene, Kamila; Liu, Jianjun; Li, Yuqing; Cox, Angela; Elliott, Graeme; Brock, Ian; Reed, Malcolm W R; Shen, Chen-Yang; Yu, Jyh-Cherng; Hsu, Giu-Cheng; Chen, Shou-Tung; Anton-Culver, Hoda; Ziogas, Argyrios; Andrulis, Irene L; Knight, Julia A; kConFab; Beesley, Jonathan; Goode, Ellen L; Couch, Fergus; Chenevix-Trench, Georgia; Hoover, Robert N; Ponder, Bruce A J; Hunter, David J; Pharoah, Paul D P; Dunning, Alison M; Chanock, Stephen J; Easton, Douglas F

    2009-01-01

    Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage1. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08–1.13, P = 4.1 × 10−23) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92–0.97, P = 1.4 × 10−8). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q. PMID:19330027

  12. Characterization of a Newly Discovered Symbiont of the Whitefly Bemisia tabaci (Hemiptera: Aleyrodidae)

    PubMed Central

    Bing, Xiao-Li; Yang, Jiao; Zchori-Fein, Einat; Wang, Xiao-Wei

    2013-01-01

    Bemisia tabaci (Hemiptera: Aleyrodidae) is a species complex containing >28 cryptic species, some of which are important crop pests worldwide. Like many other sap-sucking insects, whiteflies harbor an obligatory symbiont, “Candidatus Portiera aleyrodidarum,” and a number of secondary symbionts. So far, six genera of secondary symbionts have been identified in B. tabaci. In this study, we report and describe the finding of an additional bacterium in the indigenous B. tabaci cryptic species China 1 (formerly known as B. tabaci biotype ZHJ3). Phylogenetic analysis based on the 16S rRNA and gltA genes showed that the bacterium belongs to the Alphaproteobacteria subdivision of the Proteobacteria and has a close relationship with human pathogens of the genus Orientia. Consequently, we temporarily named it Orientia-like organism (OLO). OLO was found in six of eight wild populations of B. tabaci China 1, with the infection rate ranging from 46.2% to 76.8%. Fluorescence in situ hybridization (FISH) of B. tabaci China 1 in nymphs and adults revealed that OLOs are confined to the bacteriome and co-occur with “Ca. Portiera aleyrodidarum.” The vertical transmission of OLO was demonstrated by detection of OLO at the anterior pole end of the oocytes through FISH. Quantitative PCR analysis of population dynamics suggested a complex interaction between “Ca. Portiera aleyrodidarum” and OLO. Based on these results, we propose “Candidatus Hemipteriphilus asiaticus” for the classification of this symbiont from B. tabaci. PMID:23144129

  13. Characterization of a newly discovered symbiont of the whitefly Bemisia tabaci (Hemiptera: Aleyrodidae).

    PubMed

    Bing, Xiao-Li; Yang, Jiao; Zchori-Fein, Einat; Wang, Xiao-Wei; Liu, Shu-Sheng

    2013-01-01

    Bemisia tabaci (Hemiptera: Aleyrodidae) is a species complex containing >28 cryptic species, some of which are important crop pests worldwide. Like many other sap-sucking insects, whiteflies harbor an obligatory symbiont, "Candidatus Portiera aleyrodidarum," and a number of secondary symbionts. So far, six genera of secondary symbionts have been identified in B. tabaci. In this study, we report and describe the finding of an additional bacterium in the indigenous B. tabaci cryptic species China 1 (formerly known as B. tabaci biotype ZHJ3). Phylogenetic analysis based on the 16S rRNA and gltA genes showed that the bacterium belongs to the Alphaproteobacteria subdivision of the Proteobacteria and has a close relationship with human pathogens of the genus Orientia. Consequently, we temporarily named it Orientia-like organism (OLO). OLO was found in six of eight wild populations of B. tabaci China 1, with the infection rate ranging from 46.2% to 76.8%. Fluorescence in situ hybridization (FISH) of B. tabaci China 1 in nymphs and adults revealed that OLOs are confined to the bacteriome and co-occur with "Ca. Portiera aleyrodidarum." The vertical transmission of OLO was demonstrated by detection of OLO at the anterior pole end of the oocytes through FISH. Quantitative PCR analysis of population dynamics suggested a complex interaction between "Ca. Portiera aleyrodidarum" and OLO. Based on these results, we propose "Candidatus Hemipteriphilus asiaticus" for the classification of this symbiont from B. tabaci.

  14. Preliminary results from the observation of DT Lupus, a newly discovered oscillating Algol binary

    NASA Astrophysics Data System (ADS)

    Middleton, C. T.

    2011-10-01

    Observations using personal telescopes in light-polluted skies in Kyalami, Johannesburg, suggest that the Algol system DT Lup be re-classified as an oscillating eclipsing Algol system. Preliminary frequency calculations produce an oscillation frequency of ~8.73 cycles per day.

  15. Newly discovered ergot alkaloids in Sorghum ergot Claviceps africana occurring for the first time in Israel.

    PubMed

    Shimshoni, J A; Cuneah, O; Sulyok, M; Krska, R; Sionov, E; Barel, S; Meller Harel, Y

    2017-03-15

    Sorghum ergot is a disease caused commonly by C. africana. In 2015, ergot was identified for the first time in sorghum fields in Israel, leading to measures of eradication and quarantine. The aims of the study were to identify the ergot species by molecular and ergot alkaloid profile analysis, to determine the ergot alkaloid profile in pure honeydew and in infected sorghum silages and to estimate the safety of sorghum silages as a feed source. C. africana was rapidly and reliably identified by microscopical and molecular analysis. Dihydroergosine was identified as the major ergot alkaloid. Dihydrolysergol and dihydroergotamine were identified for the first time as significant ergot alkaloid components within the C. africana sclerotia, thereby providing for the first time a proof for the natural occurrence of dihydroergotamine. The sorghum silages were found to be safe for feed consumption, since the ergot alkaloids and the regulated mycotoxins were below their regulated limits.

  16. An Hα-selected sample of cataclysmic variables - I. Observations of newly discovered systems

    NASA Astrophysics Data System (ADS)

    Pretorius, Magaretha L.; Knigge, Christian

    2008-04-01

    Strong selection effects are present in observational samples of cataclysmic variables (CVs), complicating comparisons to theoretical predictions. The selection criteria used to define most CV samples discriminate heavily against the discovery of short-period, intrinsically faint systems. The situation can be improved by selecting CVs for the presence of emission lines. For this reason, we have constructed a homogeneous sample of CVs selected on the basis of Hα emission. We present discovery observations of the 14 CVs and two additional CV candidates found in this search. The orbital periods of 11 of the new CVs were measured; all are above 3 h. There are two eclipsing systems in the sample, and one in which we observed a quasi-periodic modulation on a ~1000s time-scale. We also detect the secondary star in the spectrum of one system, and measure its spectral type. Several of the new CVs have the spectroscopic appearance of nova-like variables, and a few display what may be SW Sex star behaviour. In a companion paper, we discuss the implications of this new sample for CV evolution.

  17. Newly Discovered Parametric Instabilities Excited by High Power Radio Waves in the Ionosphere

    NASA Astrophysics Data System (ADS)

    Bernhardt, Paul

    2010-11-01

    A powerful electromagnetic wave can decay into a large number of low frequency electrostatic waves and a scattered electromagnetic wave by generalized stimulated Brillouin scatter (GSBS). The generalization occurs in the F-layer ionosphere because of the presence of the magnetic field supporting a large number of plasma waves not present in an unmagnetized plasma. Stimulated Brillouin scatter excites the ion acoustic mode. In addition, GSBS can excite slow MHD, Alfven, fast MHD, ion cyclotron, whistler, lower hybrid, ion Bernstein waves. The first detection of this process during ionospheric modification with high power radio waves was demonstrated using the HAARP transmitter in Alaska in 2009. Subsequent experiments have provided additional verification of the GSBS process with quantitative measurements of the scattered electromagnetic waves with low frequency offsets from the pump wave. Relative to ground-based laboratory experiments with laser plasma interactions, the ionospheric HF wave interactions experiments are more completely diagnosed into terms of understanding the basic decay process of the magnetized plasma. Applications of the GSBS observations included remote sensing of the plasma state and launching propagating wave modes.

  18. Lyman-α spectral properties of five newly discovered Lyman continuum emitters

    NASA Astrophysics Data System (ADS)

    Verhamme, A.; Orlitová, I.; Schaerer, D.; Izotov, Y.; Worseck, G.; Thuan, T. X.; Guseva, N.

    2017-01-01

    Aims: We have recently reported the discovery of five low redshift Lyman continuum (LyC) emitters (LCEs) with absolute escape fractions fescLyC that range from 6 to 13%, higher than previously found and that more than double the number of low redshift LCEs. We use these observations to test theoretical predictions about a link between the characteristics of the Lyman-alpha (Lyα) line from galaxies and the escape of ionizing photons. Methods: We analyse the Lyα spectra of eight LCEs of the local Universe observed with the Cosmic Origins Spectrograph onboard the Hubble Space Telescope (our five leakers and three galaxies from the litterature), and compare their strengths and shapes to the theoretical criteria and comparison samples of local galaxies: the Lyman Alpha Reference Survey, Lyman-break analogs, Green Peas, and the high-redshift strong LyC leaker Ion2. Results: Our LCEs are found to be strong Lyα emitters, with high equivalent widths, EW(Lyα) > 70 Å, and large Lyα escape fractions, fescLyα> 20%. The Lyα profiles are all double-peaked with a small peak separation, in agreement with our theoretical expectations. They also have no underlying absorption at the Lyα position. All these characteristics are very different from the Lyα properties of typical star-forming galaxies of the local Universe. A subset of the comparison samples (2-3 Green Pea galaxies) share these extreme values, indicating that they could also be leaking. We also find a strong correlation between the star formation rate surface density and the escape fraction of ionizing photons, indicating that the compactness of star-forming regions plays a role in shaping low column density paths in the interstellar medium of LCEs. Conclusions: The Lyα properties of LCEs are peculiar: Lyα can be used as a reliable tracer of LyC escape from galaxies, complementing other indirect diagnostics proposed in the literature.

  19. SDSSJ102111.02+491330.4: A Newly Discovered Gravitationally Lensed Quasar

    SciTech Connect

    Pindor, B; Eisenstein, D J; Gregg, M D; Becker, R H; Inada, N; Oguri, M; Hall, P B; Johnston, D E; Richards, G T; Schneider, D P; Turner, E L; Brasi, G; Hinz, P M; Kenworthy, M A; Miller, D; Barentine, J C; Brewington, H J; Brinkmann, J; Harvanek, M; Kleinman, S J; Krzesinski, J; Long, D; Neilsen Jr., E H; Newman, P R; Nitta, A; Snedden, S A; York, D G

    2005-11-10

    We report follow-up observations of two gravitational lens candidates identified in the Sloan Digital Sky Survey (SDSS) dataset. We have confirmed that SDSS J102111.02+491330.4 is a previously unknown gravitationally lensed quasar. This lens system exhibits two images of a z = 1.72 quasar, with an image separation of 1''.14 {+-} 0.04. Optical and near-IR imaging of the system reveals the presence of the lensing galaxy between the two quasar images. Observations of SDSS J112012.12+671116.0 indicate that it is more likely a binary quasar than a gravitational lens. This system has two quasars at a redshift of z = 1.49, with an angular separation of 1''.49 {+-} 0.02. However, the two quasars have markedly different SEDs and no lens galaxy is apparent in optical and near-IR images of this system. We also present a list of 31 SDSS lens candidates which follow-up observations have confirmed are not gravitational lenses.

  20. Strategy for incorporating newly discovered causative genetic variants into genomic evaluations

    USDA-ARS?s Scientific Manuscript database

    With sequence data available for an increasing number of dairy cattle, discovery of causative genetic variants is expected to be frequent. Current genomic evaluation systems require genotypes for all markers that contribute to an evaluation. A minimum number of animals with an observation for a new ...

  1. Crystallization of a newly discovered histidine acid phosphatase from Francisella tularensis

    SciTech Connect

    Felts, Richard L.; Reilly, Thomas J.; Calcutt, Michael J.; Tanner, John J.

    2006-01-01

    A histidine acid phosphatase from the CDC Category A pathogen F. tularensis has been crystallized in space group P4{sub 1}2{sub 1}2, with unit-cell parameters a = 61.96, c = 210.78 Å. A 1.75 Å resolution data set was collected at Advanced Light Source beamline 4.2.2. Francisella tularensis is a highly infectious bacterial pathogen that is considered by the Centers for Disease Control and Prevention to be a potential bioterrorism weapon. Here, the crystallization of a 37.2 kDa phosphatase encoded by the genome of F. tularensis subsp. holarctica live vaccine strain is reported. This enzyme shares 41% amino-acid sequence identity with Legionella pneumophila major acid phosphatase and contains the RHGXRXP motif that is characteristic of the histidine acid phosphatase family. Large diffraction-quality crystals were grown in the presence of Tacsimate, HEPES and PEG 3350. The crystals belong to space group P4{sub 1}2{sub 1}2, with unit-cell parameters a = 61.96, c = 210.78 Å. The asymmetric unit is predicted to contain one protein molecule, with a solvent content of 53%. A 1.75 Å resolution native data set was recorded at beamline 4.2.2 of the Lawrence Berkeley National Laboratory Advanced Light Source. Molecular-replacement trials using the human prostatic acid phosphatase structure as the search model (28% amino-acid sequence identity) did not produce a satisfactory solution. Therefore, the structure of F. tularensis histidine acid phosphatase will be determined by multiwavelength anomalous dispersion phasing using a selenomethionyl derivative.

  2. The Role of Newly Discovered Exotoxin (S Toxin) in Pseudomonas aeruginosa Infections

    DTIC Science & Technology

    1981-08-01

    J. Sadoff (Walter Reed Army Institute of Research) on Pseudomonas research and purified and supplied them with purified diphtheria toxin and...C.R. Suppression of cytotoxicity of diphtheria toxin by monoclonal antibodies against phos- photidyl-inositol phosphate. J. Biophysics (In press...the specific antitoxins were determined by double diffusion precipitin analysis . Indirect direct immunofluorescent staining was performed on frozen

  3. Newly discovered subsidence at Lassen Peak, southern Cascade Range, California, from InSAR and GPS

    NASA Astrophysics Data System (ADS)

    Poland, M.; Bawden, G.; Lisowski, M.; Dzurisin, D.

    2004-12-01

    ERS interferograms spanning the 1996-2000 time interval indicate up to 1 cm/yr of subsidence over a ~40 km-diameter area centered about 5 km southeast of Lassen Peak, California. Dry tilt and EDM measurements of the volcanic region completed in 1981, 1982, and 1984 showed no significant deformation, but this interval is too short to accumulate detectible deformation at the 1996 to 2000 rates. Since it is unclear based on InSAR results alone whether the subsidence is a recent or more long-lived process, we resurveyed one dry tilt array and measured five EDM line lengths with GPS in July 2004. Results from the three-station dry tilt array were inconclusive, likely due to an unstable benchmark in the array. Line lengths, however, shortened by up to 14 cm suggesting that the subsidence has been ongoing since at least 1981. Four mechanisms may account for the deformation observed near Lassen Peak: 1) magma withdrawal from a shallow chamber into a deeper crustal reservoir, 2) cooling and/or crystallization of a subsurface magma body, 3) loss of hydrothermal fluids and subsequent cooling, and 4) tectonic motion that is creating a pull-apart basin or other similar structure. The possible sources are similar to those invoked to explain subsidence at Medicine Lake volcano, located 100 km to the north. Geophysical and petrologic studies have found no evidence for a large magma reservoir (> 5 km diameter) in the upper crust beneath the Lassen Peak area; therefore, the first two mechanisms are unlikely. The area surrounding Lassen Peak is known for numerous hydrothermal features, but the relatively shallow depth of the hydrothermal system is not consistent with the spatial extent of the subsidence. In contrast, geologic studies confirm that Basin and Range extension is occurring in the region and the Walker Lane zone of dextral shear passes through the subsiding area. Interaction between these tectonic regimes may result in the formation of a pull-apart basin or other structure that is responsible for the observed subsidence. We will present results of inverse modeling that should help distinguish between these mechanisms, as well as additional interferograms that will better constrain the behavior of the subsidence over time.

  4. A Newly Discovered Source with Peculiar Chemistry Near the HH 111/HH 121 Protostellar System

    NASA Astrophysics Data System (ADS)

    Wiseman, Jennifer J.; Sewilo, Marta M.; Indebetouw, Remy; Lindberg, Johan; Charnley, Steven B.; Pineda, Jaime E.

    2017-01-01

    We present the results of Very Large Array NH3 (1,1) and (2,2) observations of the HH 111 / HH 121 protostellar system located in L1617 in the Orion B molecular cloud. HH 111, with a spectacular collimated optical jet, is one of the most well-known Herbig-Haro objects. We report a detection of a new source (NH3-S) in the vicinity of HH 111/HH 121 (~15 arcsec or 0.03 pc from the HH 111 jet source), in two epochs of ammonia observations. Interestingly, this constitutes the first detection of this source, in a region which has been thoroughly covered previously by both continuum and spectral line interferometric observations. Comparisons of these ammonia observations with those of several other tracers indicate peculiar chemistry in this clump. The position of the source with respect to the Herbig-Haro jet suggests that it may be an externally illuminated molecular clump. The Herbig-Haro objects thus provide a useful tool for studying molecular clumps through their elucidated response to radiation; in turn, the clumpiness of molecular clouds is of relevance to the initiation of star formation.

  5. Mixed vitiligo of Blaschko lines: a newly discovered presentation of vitiligo responsive to combination treatment.

    PubMed

    Kovacevic, Maja; Stanimirovic, Andrija; Vucic, Majda; Goren, Andy; Situm, Mirna; Lukinovic Skudar, Vesna; Lotti, Torello

    2016-07-01

    Vitiligo, depigmenting disorder of the skin and mucous membranes, affects up to 1% of the population worldwide. It is classified into four major types: segmental, non-segmental, mixed, and unclassified type. Non-segmental vitiligo refers to non-dermatomal distribution of lesions, while dermatomal distribution of lesions is present in patients with segmental vitiligo. Segmental vitiligo can also follow Blaschko lines - pathways of epidermal cell migration and proliferation during the development of the fetus. Here, we present patient with segmental and non-segmental vitiligo following Blaschko lines with excellent therapeutic response to combined therapy. Prior to our report, a case of segmental and non-segmental vitiligo followed by Blaschko lines was never described, therefore we suggest the term "mixed vitiligo of Blaschko lines" to describe this entity. This is also a rare case in which 90% repigmentation was achieved in patient with segmental and nonsegmental vitiligo following Blaschko lines in only 2 months of combined therapy. © 2016 Wiley Periodicals, Inc.

  6. Control of Alicyclobacillus acidoterrestris in fruit juices by a newly discovered bacteriocin.

    PubMed

    Pei, Jinjin; Yue, Tianli; Yuan, Yahong

    2014-03-01

    Alicyclobacillus acidoterrestris is one of the most spoilage-causing bacteria in fruit juices. Control of A. acidoterrestris in fruit juices by bificin C6165 (Pei et al. in J Appl Microbiol 114(5):1273-1284, 2013), a bacteriocin produced by Bifidobacterium animalis subsp. animalis CICC 6165, was described in this study. Activity spectrum of bificin C6165 was investigated and sixteen strains of A. acidoterrestris were sensitive to bificin C6165 in diluted Apple Juices. In the commercial fruit juices, vegetative cells of A. acidoterrestris were inactivated by bificin C6165 at 40 μg/ml. The inhibitory effect of bificin C6165 was better at lower pH (pH 3.5) and at a higher temperature of 45 °C. Furthermore, electron microscopy examination of the vegetative cells treated with bacteriocin revealed substantial cell damage and bacterial lysis. The result suggested that primary mode of action of bificin C6165 was most probably due to pore formation. Although no significantly activity of bificin C6165 was observed against the endospores of A. acidoterrestris in commercial apple juice, the addition of bacteriocin contributed to the reduction of the thermal resistance of A. acidoterrestris spores. Additionally, encapsulation of bificin C6165 with Ca-alginate gel was investigated. Encapsulation of bificin C6165 provided a promising method to control A. acidoterrestris in food juice industry.

  7. Genetic analysis of saffold virus-Penang in relation to other newly discovered saffold viruses.

    PubMed

    Voon, Kenny; Ng, Qi Mei; Yu, Meng; Wang, Lin-Fa; Chua, Kaw Bing

    2012-07-01

    Viruses in the family Picornaviridae are classified into nine genera. Within the family Picornaviridae, two species: Encephalomyocarditis virus and Theilovirus, are listed under the genus Cardiovirus. A novel Theilovirus, Saffold virus (SAFV), was first reported in 2007. Since then, numerous SAFV isolates have been detected around the world and genetic recombinations have been reported among them. In 2009, SAFV-Penang was isolated from a febrile child with influenza-like illness in Malaysia. SAFV-Penang is a genotype 3 SAFV. In this study we investigated the genome features of SAFV-Penang to exclude the possibility it is a recombinant variant. SAFV-Penang was found not to be a recombinant variant but to have three unique non-synonymous substitutions, alanine [A689], lysine [K708] and isoleucine [I724] in the VP1 protein.

  8. TXNDC5, a Newly Discovered Disulfide Isomerase with a Key Role in Cell Physiology and Pathology

    PubMed Central

    Horna-Terrón, Elena; Pradilla-Dieste, Alberto; Sánchez-de-Diego, Cristina; Osada, Jesús

    2014-01-01

    Thioredoxin domain-containing 5 (TXNDC5) is a member of the protein disulfide isomerase family, acting as a chaperone of endoplasmic reticulum under not fully characterized conditions As a result, TXNDC5 interacts with many cell proteins, contributing to their proper folding and correct formation of disulfide bonds through its thioredoxin domains. Moreover, it can also work as an electron transfer reaction, recovering the functional isoform of other protein disulfide isomerases, replacing reduced glutathione in its role. Finally, it also acts as a cellular adapter, interacting with the N-terminal domain of adiponectin receptor. As can be inferred from all these functions, TXNDC5 plays an important role in cell physiology; therefore, dysregulation of its expression is associated with oxidative stress, cell ageing and a large range of pathologies such as arthritis, cancer, diabetes, neurodegenerative diseases, vitiligo and virus infections. Its implication in all these important diseases has made TXNDC5 a susceptible biomarker or even a potential pharmacological target. PMID:25526565

  9. A newly discovered Pliocene volcanic field on the western Sardinia continental margin (western Mediterranean)

    NASA Astrophysics Data System (ADS)

    Conforti, Alessandro; Budillon, Francesca; Tonielli, Renato; De Falco, Giovanni

    2016-02-01

    A previously unknown submerged volcanic field offshore western Sardinia (western Mediterranean Sea), has been identified based on swath bathymetric data collected in 2009, 2010 and 2013, and high-resolution seismic profiles collected in 2011 and 2013. About 40 conical-shaped volcanic edifices (maximum width of about 1600 m and maximum height of about 180 m) and several lava outcrops (up to 1,200 m wide) were recognized at 20 to 150 m water depth over an area of 800 km2. The volcanic edifices are mainly eruptive monogenic vents, mostly isolated with a rather distinct shape, or grouped to form a coalescent volcanic body in which single elements are often still recognizable. High-resolution seismics enabled identifying relationships between the volcanic bodies and continental margin successions. The edifices overlie a major erosional surface related to the margin exposure following the Messinian salinity crisis, and are overlain by or interbedded with an early Pliocene marine unit. This seismo-stratigraphic pattern dates the volcanic activity to the early Pliocene, in agreement with the radiometric age of the Catalano island lavas (4.7 Ma) reported in earlier studies. The morphometry of the volcanic bodies suggests that cone erosion was higher at shallow water depths. Indeed, most of the shallow edifices are strongly eroded and flattened at 125 to 130 m water depth, plausibly explained by recurrent sub-aerial exposure during Pleistocene sea-level lowstands, whereas cones in deeper water are much better preserved. Volcanic vents and lava deposits, hereafter named the Catalano volcanic field (CVF), are emplaced along lineaments corresponding to the main directions of the normal fault system, which lowered the Sinis Basin and the western Sardinia continental margin. The CVF represents a volumetrically relevant phase of the late Miocene - Quaternary anorogenic volcanic cycle of Sardinia, which is related to the first stage of the extensional tectonics affecting the island since the late Miocene.

  10. The Role of Newly Discovered Exotoxin (S Toxin) in Pseudomonas aeruginosa Infections

    DTIC Science & Technology

    1979-08-01

    described (13). An over- pretreatment with urea and dithiothreitol night culture (4 ml) inoculated into 100 ml of medium (DTT) (13), whereas such... urea and DTT on enzyme activity in mouse skin extracts. Table 2. (b) Comparison of EF-2 levels in tissues from Ps 388 kifected and noninfected control...neutropenic rabbits following conjunctival inoculation . Table 5. D. Discussion I1. Studies on the assay conditions for measuring the 10-15 enzymatic

  11. TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology.

    PubMed

    Horna-Terrón, Elena; Pradilla-Dieste, Alberto; Sánchez-de-Diego, Cristina; Osada, Jesús

    2014-12-17

    Thioredoxin domain-containing 5 (TXNDC5) is a member of the protein disulfide isomerase family, acting as a chaperone of endoplasmic reticulum under not fully characterized conditions As a result, TXNDC5 interacts with many cell proteins, contributing to their proper folding and correct formation of disulfide bonds through its thioredoxin domains. Moreover, it can also work as an electron transfer reaction, recovering the functional isoform of other protein disulfide isomerases, replacing reduced glutathione in its role. Finally, it also acts as a cellular adapter, interacting with the N-terminal domain of adiponectin receptor. As can be inferred from all these functions, TXNDC5 plays an important role in cell physiology; therefore, dysregulation of its expression is associated with oxidative stress, cell ageing and a large range of pathologies such as arthritis, cancer, diabetes, neurodegenerative diseases, vitiligo and virus infections. Its implication in all these important diseases has made TXNDC5 a susceptible biomarker or even a potential pharmacological target.

  12. Reovirus genomes from plant-feeding insects represent a newly discovered lineage within the family Reoviridae

    USDA-ARS?s Scientific Manuscript database

    A complex set of double-stranded RNAs (dsRNAs) was isolated from threecornered alfalfa hopper (Spissistilus festinus), a plant-feeding hemipteran pest. A subset of these dsRNAs constitute the genome of a new reovirus, provisionally designated Spissistilus festinus reovirus (SpFRV). SpFRV was prese...

  13. Examination of a Newly Discovered human Retrovirus, XMRV, in Breast Cancer

    DTIC Science & Technology

    2012-07-01

    Metamorph software provided by the Karmanos Cancer Institute Microscopy, Imaging and Cytometry Resources (KCI MICR ) Core facility. Based on our results...infected LNCaP cells at 200x magnification using a Zeiss Axioplan 2 fluorescence microscope (KCI MICR Core). Fluorescence images of XMRV-infected LNCaP...hematoxylin revealing blue nuclei. Photomicrographs were taken at 400x magnification with a Zeiss Axiophot microscope (KCI MICR Core). 7 Using the

  14. Examination of a Newly Discovered Human Retrovirus, XMRV, in Breast Cancer

    DTIC Science & Technology

    2011-07-01

    microscope and Metamorph software provided by the Karmanos Cancer Institute Microscopy, Imaging and 6 Cytometry Resources (KCI MICR ) Core facility. Based...Zeiss Axioplan 2 fluorescence microscope (KCI MICR Core). Fluorescence images of XMRV-infected LNCaP cells treated with either (B) secondary goat anti...magnification with a Zeiss Axiophot microscope (KCI MICR Core). KEY RESEARCH ACCOMPLISHMENTS: • Infectious XMRV was prepared by transfecting human 293T

  15. Photometry and spectroscopy of a newly discovered polar - Nova Cygni 1975 (V1500 CYG)

    NASA Technical Reports Server (NTRS)

    Kaluzny, Janusz; Chlebowski, Tomasz

    1988-01-01

    The paper reports photometric and spectroscopic observations which led to the conclusion that Nova Cygni 1975 (V1500 Cyg) is a polar (of AM Her-type).The CCD photometry confirms the constancy of the photometric period which is again interpreted as an orbital cycle. The time-resolved MMT spectra make it possible to reconstruct, under several assumptions, the basic system parameters: M1=0.9M solar mass and M2=0.31M solar mass.

  16. Newly discovered populations of salamanders from Siskiyou County California represent a species distinct from Plethodon Stormi.

    Treesearch

    Louise S. Mead; David R. Clayton; Richard S. Nauman; Deanna H. Olson; Michael E. Pfrender

    2005-01-01

    Plethodon stormi and Plethodon elongatus are two closely related species of plethodontid salamanders that are restricted to the Klamath Province of northwestern California and southwestern Oregon. Discovery of three localities south of the Klamath River, in the Scott River drainage, not assignable to either P....

  17. Ecological genomics of the newly discovered diazotrophic filamentous cyanobacterium ESFC-1

    NASA Astrophysics Data System (ADS)

    Everroad, C.; Bebout, B.; Bebout, L. E.; Detweiler, A. M.; Lee, J.; Mayali, X.; Singer, S. W.; Stuart, R.; Weber, P. K.; Woebken, D.; Pett-Ridge, J.

    2014-12-01

    Cyanobacteria-dominated microbial mats played a key role in the evolution of the early Earth and provide a model for exploring the relationships between ecology, evolution and biogeochemistry. A recently described nonheterocystous filamentous cyanobacterium, strain ESFC-1, has been shown to be a major diazotroph year round in the intertidal microbial mat system at Elkhorn Slough, CA, USA. Based on phylogenetic analyses of the 16s RNA gene, ESFC-1 appears to belong to a unique, genus-level divergence within the cyanobacteria. Consequently, the draft genome sequence of this strain has been determined. Here we report features of this genome, particularly as they relate to the ecological functions and capabilities of strain ESFC-1. One striking feature of this cyanobacterium is the apparent lack of a functional bi-directional hydrogenase typically expected to be found within a diazotroph; consortia- and culture-based experiments exploring the metabolic processes of ESFC-1 also indicate that this hydrogenase is absent. Co-culture studies with ESFC-1 and some of the dominant heterotrophic members within the microbial mat system, including the ubiquitous Flavobacterium Muricauda sp., which often is found associated with cyanobacteria in nature and in culture collections worldwide, have also been performed. We report on these species-species interactions, including materials exchange between the cyanobacterium and heterotrophic bacterium. The combination of genomics with culture- and consortia-based experimental research is a powerful tool for understanding microbial processes and interactions in complex ecosystems.

  18. Nothing new under the sun: an examination of newly discovered inventions and techniques.

    PubMed

    Ring, M E

    1980-01-01

    Dental practitioners of generations ago had the foresight and ingenuity to produce many useful ideas and techniques that, unfortunately, were forgotten. Great effort could have been spared had closer attention been given to the inventions and successes of our forebears. Perhaps, the status of dentistry might be even greater had we been more aware of our heritage and had we built on our history.

  19. The Newly-Discovered Outer Halo Globular Cluster System of M31

    NASA Astrophysics Data System (ADS)

    Mackey, D.; Huxor, A.; Ferguson, A.

    2012-08-01

    In this contribution we describe the discovery of a large number of globular clusters in the outer halo of M31 from the Pan-Andromeda Archaeological Survey (PAndAS). New globular clusters have also been found in the outskirts of M33, and NGC 147 and 185. Many of the remote M31 clusters are observed to preferentially project onto tidal debris streams in the stellar halo, suggesting that much of the outer M31 globular cluster system has been assembled via the accretion of satellite galaxies. We briefly discuss the global properties of the M31 halo globular cluster system.

  20. CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF NEWLY DISCOVERED IODOACID DRINKING WATER DISINFECTION BYPRODUCTS

    EPA Science Inventory

    Iodoacid drinking water disinfection byproducts (DBPs) were recently uncovered in drinking water samples from source water with a high bromide/iodide concentration that was disinfected with chloramines. The purpose of this paper is to report the analytical chemical identification...

  1. [Inline skating, an old sport, newly discovered: harmless or a potential danger with socioeconomic effects?].

    PubMed

    Largiadèr, U; Nufer, M; Hotz, T; Käch, K

    1998-02-18

    Over a period of one year, all accidents associated with in-line skating (ILS) were surveyed. Sport-specific data was recorded with a standardized questionnaire. The study comprised 66 patients with 75 injuries (48 upper limb, 16 skull, eight lower limb, three trunk). We were looking after 42 male and 24 female patients with an average age of 20 years (5-53 years). Twenty-seven patients (40%) had to be treated as inpatients. Overall, the most frequent injury (one third of all injuries) was forearm fracture close to the wrist (21 radius fractures, four radioulnar fractures). It had to be reset in 20 cases. Additional internal fixation was required in 10 cases (Kirschner wire osteosynthesis, intramedullary nailing or plate osteosynthesis). Only five patients could be treated with plaster cast fixation alone. Most patients with injuries in the vicinity of the wrist were not wearing a wrist protector at the time of the accident. The most frequent reasons given for not wearing protectors was forgetfulness or the high price of protectors. However, there were also two distal radius fractures and a disc injury in the wrist in patients who had been wearing wrist protectors. In most cases, ILS accidents lead to appreciable damage requiring a healing period of several weeks to months (average period of loss of work 41 days). The bfu (advisory center for accident prevention) reckons with 60,000 ILS cases annually in Switzerland. These injuries are thus of great socioeconomic importance. In the future, better risk behavior must be achieved by informing the population (wearing protectors, especially for the wrist and head, attendance of training courses).

  2. A Homo habilis maxilla and other newly-discovered hominid fossils from Olduvai Gorge, Tanzania.

    PubMed

    Clarke, R J

    2012-08-01

    In 1995, a 1.8 million year old hominid maxilla with complete dentition (OH 65) was excavated from Bed I in the western part of Olduvai Gorge. The molar crowns are small relative to the long flaring roots, and the root of the canine is very long and straight. The broad maxilla with wide U-shaped palate and the form of the tooth roots closely match those of KNM-ER 1470 which, in its parietal size and morphology, matches the type specimen of Homo habilis, OH 7. Thus, OH 65 and KNM-ER 1470 group with OH 7 as representatives of H. habilis while some other Olduvai specimens, such as OH 13 and OH 24, have more in common in terms of morphology and brain size with Australopithecus africanus. Between 1995 and 2007, the OLAPP team has recovered teeth of eight other hominid individuals from various parts of Olduvai Gorge. These have been identified as belonging to H. habilis, Paranthropus boisei, and Australopithecus cf. africanus.

  3. Filifactor alocis: The Newly Discovered Kid on the Block with Special Talents

    PubMed Central

    Aruni, W.; Chioma, O.; Fletcher, H.M.

    2014-01-01

    Infection-induced periodontal disease has been primarily focused on a small group of periodontal pathogens. A paradigm shift, based on data emerging from the oral microbiome project, now suggests the involvement of as-yet-unculturable and fastidious organisms. Collectively, these studies have demonstrated that there are changes in the periodontal status associated with shifts in the composition of the bacterial community in the periodontal pocket. In addition, it is likely that the emerging new pathogens may play a more significant role in the disease. One of the organisms previously unrecognized is Filifactor alocis. While this Gram-positive anaerobic rod has been identified in peri-implantitis, in endodontic infections, and in patients with localized aggressive periodontitis, its presence is now observed at significantly higher levels in patients with adult periodontitis or refractory periodontitis. Its colonization properties and its potential virulence attributes support the proposal that F. alocis should be included as a diagnostic indicator of periodontal disease. Moreover, these emerging characteristics would be consistent with the polymicrobial synergy and dysbiosis (PSD) periodontal pathogenesis model. Here, unique characteristics of F. alocis are discussed. F. alocis has specific factors that can modulate multiple changes in the microbial community and host cell proteome. It is likely that such variations at the molecular level are responsible for the functional changes required to mediate the pathogenic process. PMID:24898946

  4. Intracrystalline porosity - a newly discovered pore type in dolostone reservoirs and implications for dedolomitization and pseudospiculites

    SciTech Connect

    Jacka, A.D.

    1984-04-01

    Intracrystalline porosity consists of hollow dolomite crystals. It forms when anhydrite, which had replaced cores of dolomite crystals, was dissolved. Significant volumes of intracrystalline porosity have been preserved in subsurface Permian dolostones of the Permian basin and in outcrops of Lower Cretaceous dolostones of Texas. Anhydrite can be seen replacing organic-rich cores of dolomite crystals in Permian and Jurassic (Smackover) dolostones. Dolomite crystals, which replace original carbonate, commonly appear cloudy because of organic inclusions. After dolomitization, continued flux of the dolomitizing fluid caused precipitation of clear rims on the ''cloudy'' crystals. Anhydrite tends to replace the organic-rich cores, leaving the clear epitaxial rims to form ''pill box'' structures. When anhydrite was dissolved, many hollow dolomite crystals collapsed and fragments became transported as vadose internal sediment. Obtuse and acute angles of these hollow dolomite rims superficially resemble sponge spicules, and pseudospiculites are layers of vadose internal sediment in which numerous fragments of hollow dolomite rims have been deposited in solution channels. Hollow dolomite crystals and pseudospiculites constitute evidence for disconformity and also represent subtle indications of vanished sulfates. In many instances, calcite cement was precipitated within intracrystalline pores and is misinterpreted as partial dedolomitization. Such calcite cement can be distinguished from dedolomite, because the calcite is not syntaxial with dolomite rims, as it would be in dedolomitization. In some Permian dolostone intervals, intracrystalline porosity is predominant pore type. Molds formed by dissolution of replacement porphyroblasts and nodules of anhydrite also commonly were formed along with intracrystalline pores and all represent tertiary (third order) voids.

  5. Newly discovered eclogite in the southern Appalachian orogen, northwestern North Carolina

    NASA Astrophysics Data System (ADS)

    Willard, R. A.; Adams, Mark G.

    1994-05-01

    Recent detailed geologic mapping in the Blue Ridge belt of northwestern North Carolina has revealed the first reported eclogite ( sensu stricto) in the southern Appalachian orogen. The eclogite occurs at the base of the Ashe Metamorphic Suite within a shear zone that separates the Spruce Pine thrust sheet from the underlying Grenville-age basement rocks. This contact juxtaposes rocks of apparent oceanic affinities (predominantly metapelite, metabasite, and meta-ultramafic rocks) with rocks of the ancient North American craton. The primary metamorphic assemblage in the eclogite is garnet + omphacite + quartz + rutile. Hornblende and plagioclase occur only as retrograde amphibolite facies phases in the eclogite. Pressure-temperature estimates for the primary eclogite assemblage are consistent with minimum pressures of 13-17 kbar at 625-790°C, while the retrograde amphibolite facies assemblage suggests conditions of 8.5-12 kbar and 650-730°C. Ultramafic blocks also occur within the shear zone containing the eclogite. The presence of high-pressure metamorphic rocks associated with ultramafic rocks and pelitic schists within a shear zone separating continental rocks from oceanic rocks is strong evidence for an ancient subduction event and indicates that at least part of the Ashe Metamorphic Suite is a subduction-related, accretionary mélange.

  6. Search for an IR counterpart to the newly discovered transient Swift J11822.3-1606

    NASA Astrophysics Data System (ADS)

    Bandyopadhyay, R. M.; Lucas, P. W.; Maccarone, T.

    2011-07-01

    We have searched for potential near-infrared counterparts to the new Galactic Center X-ray transient, Swift J1822.3-1606 (ATEL #3488, #3489, #3490, #3491, #3493, #3495, #3496, #3501) using the UKIDSS Galactic Plane Survey (GPS) Catalog (Lucas et al., 2008, MNRAS, 391, 136). Within the enhanced Swift-XRT error circle (1.8" radius) centered at RA 18:22:18.00, Dec -16:04:26.8 (ATel #3493), there are two infrared stellar sources in the UKIDSS GPS catalog: RA Dec J H K star 1 18:22:17.9 -16:04:25.9 13.90 12.37 11.65 star 2 18:22:18:0 -16:04:28.2 16.50 15.44 14.97 These are the same as "S1" and "S2" identified by Gorosabel et al.

  7. Denying humanness to others: a newly discovered mechanism by which violent video games increase aggressive behavior.

    PubMed

    Greitemeyer, Tobias; McLatchie, Neil

    2011-05-01

    Past research has provided abundant evidence that playing violent video games increases aggressive behavior. So far, these effects have been explained mainly as the result of priming existing knowledge structures. The research reported here examined the role of denying humanness to other people in accounting for the effect that playing a violent video game has on aggressive behavior. In two experiments, we found that playing violent video games increased dehumanization, which in turn evoked aggressive behavior. Thus, it appears that video-game-induced aggressive behavior is triggered when victimizers perceive the victim to be less human.

  8. Inflorescences of Neotropical herbs as a newly discovered microhabitat for myxomycetes.

    PubMed

    Schnittler, Martin; Stephenson, Steven L

    2002-01-01

    An assemblage of myxomycetes associated with inflorescences of large Neotropical herbs, a microhabitat not previously known to support these organisms, is described and characterized ecologically from a number of study sites in Costa Rica, Ecuador, and Puerto Rico. Thirty-one different taxa were found among 652 specimens of myxomycetes recorded in the field or obtained from 358 moist chamber cultures prepared with decaying floral parts. A comparison with the results of 696 moist chamber cultures prepared with various other litter substrates showed that thirteen myxomycete taxa occurred more often on inflorescences. Six taxa had a strong preference for this microhabitat, and three of those seem to be new for the Neotropics. Correspondence analysis of the data set compiled for inflorescences indicated that the assemblage of myxomycetes was relatively consistent across all of the various study sites. The actual myxomycete substrates were the rapidly decaying floral parts enclosed by the massive, still living bracts. Richest in myxomycetes were species of Heliconia and Costus. Here, nectar residuals probably promoted a rapidly developing community of yeasts and bacteria. A high density of these organisms was indicated by the frequent occurrence of myxobacteria in the moist chamber cultures prepared with floral parts. Results from canonical correspondence analysis suggested that a substrate pH between 8 and 9 and the presence of massive, compact inflorescences on plants occurring at lower elevations in localities with moderate annual rainfall provide optimal conditions for inflorescence-inhabiting myxomycetes. An incidental dispersal of myxomycete spores by birds that pollinate the flowers or feed upon the fruits seems possible and may have accounted for the high degree of preference exhibited by some of the inflorescence-inhabiting myxomycetes, for which the term "floricolous" is proposed.

  9. Effectiveness of the modified progressive aerobic capacity endurance run test for assessing aerobic fitness in Hispanic children who are obese.

    PubMed

    Graham, Marilynn H; Bush, Jill A; Olvera, Norma; Puyau, Maurice R; Butte, Nancy F

    2014-10-01

    The purpose of this study was to evaluate the effectiveness of the progressive aerobic capacity endurance run (PACER) and a newly designed modified PACER (MPACER) for assessing aerobic fitness in Hispanic children who are obese. Thirty-nine (aged 7-12 years) children who were considered obese (≥ 95 th body mass index [BMI] percentile) and 16 children who were considered normal weight (<85th BMI percentile) participated in this study. Performance outcomes included test duration (in minutes) and exercise heart rate (HR) (first-stage and peak HR) for each test. Ninety-five percent confidence intervals and independent t-tests were used to assess differences in primary outcomes. Mean PACER test duration was 1.6 ± 0.6 and 3.1 ± 1.3 minutes for children who were obese and normal weight, respectively. Modified PACER duration was higher than 3 minutes for the obese (3.6 ± 0.6 minutes) and normal weight (5.3 ± 1.2 minutes) groups. Children first-stage HR, expressed as a percent of peak HR, was above the predicted anaerobic threshold during the PACER, but below the anaerobic threshold during the MPACER. Relative first-stage HR was not significantly different between groups for the PACER, but they were significantly different between groups for the MPACER. In conclusion, the MPACER was a better alternative than the PACER for assessing aerobic fitness in Hispanic children who were normal weight and obese. When validated, this modified field test could be used to assess aerobic fitness in Hispanic children, particularly those who are overweight or obese. Additionally, the study provides evidence in which physical educators, personal trainers, and others most apt to assess aerobic fitness in children who are obese, should modify tests originally designed for the population who are normal weight.

  10. Die aerobe Glykolyse der Tumorzelle

    NASA Astrophysics Data System (ADS)

    Schneider, Friedhelm

    1981-01-01

    A high aerobic glycolysis (aerobic lactate production) is the most significant feature of the energy metabolism of rapidly growing tumor cells. Several mechanisms, which may be different in different cell lines, seem to be involved in this characteristic of energy metabolism of the tumor cell. Changes in the cell membrane leading to increased uptake and utilization of glucose, a high level of fetal types of isoenzymes, a decreased number of mitochondria and a reduced capacity to metabolize pyruvate are some factors which must be taken into consideration. It is not possible to favour one of them at the present time.

  11. Discovering Network Structure Beyond Communities

    NASA Astrophysics Data System (ADS)

    Nishikawa, Takashi; Motter, Adilson E.

    2011-11-01

    To understand the formation, evolution, and function of complex systems, it is crucial to understand the internal organization of their interaction networks. Partly due to the impossibility of visualizing large complex networks, resolving network structure remains a challenging problem. Here we overcome this difficulty by combining the visual pattern recognition ability of humans with the high processing speed of computers to develop an exploratory method for discovering groups of nodes characterized by common network properties, including but not limited to communities of densely connected nodes. Without any prior information about the nature of the groups, the method simultaneously identifies the number of groups, the group assignment, and the properties that define these groups. The results of applying our method to real networks suggest the possibility that most group structures lurk undiscovered in the fast-growing inventory of social, biological, and technological networks of scientific interest.

  12. The Transition from Aerobic to Anaerobic Metabolism.

    ERIC Educational Resources Information Center

    Skinner, James S.; McLellan, Thomas H.

    1980-01-01

    The transition from aerobic to anaerobic metabolism is discussed. More research is needed on different kinds of athletes and athletic activities and how they may affect aerobic and anaerobic metabolisms. (CJ)

  13. The Transition from Aerobic to Anaerobic Metabolism.

    ERIC Educational Resources Information Center

    Skinner, James S.; McLellan, Thomas H.

    1980-01-01

    The transition from aerobic to anaerobic metabolism is discussed. More research is needed on different kinds of athletes and athletic activities and how they may affect aerobic and anaerobic metabolisms. (CJ)

  14. HUBBLE AND KECK DISCOVER GALAXY BUILDING BLOCK

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This NASA Hubble Space Telescope image shows a very small, faint galaxy 'building block' newly discovered by a unique collaboration between ground- and space-based telescopes. Hubble and the 10-meter Keck Telescopes in Hawaii joined forces, using a galaxy cluster which acts as gravitational lens to detect what scientists believe is one of the smallest very distant objects ever found. The galaxy cluster Abell 2218 was used by a team of European and American astronomers led by Richard Ellis (Caltech) in their systematic search for intrinsically faint distant star-forming systems. Without help from Abell 2218's exceptional magnifying power to make objects appear about 30 times brighter, the galaxy building block would have been undetectable. In the image to the right, the object is seen distorted into two nearly identical, very red 'images' by the gravitational lens. The image pair represents the magnified result of a single background object gravitationally lensed by Abell 2218 and viewed at a distance of 13.4 billion light-years. The intriguing object contains only one million stars, far fewer than a mature galaxy, and scientists believe it is very young. Such young star-forming systems of low mass at early cosmic times are likely to be the objects from which present-day galaxies have formed. In the image to the left, the full overview of the galaxy cluster Abell 2218 is seen. This image was taken by Hubble in 1999 at the completion of Hubble Servicing Mission 3A. Credit: NASA, ESA, Richard Ellis (Caltech) and Jean-Paul Kneib (Observatoire Midi-Pyrenees, France) Acknowledgment: NASA, A. Fruchter and the ERO Team (STScI and ST-ECF)

  15. HUBBLE AND KECK DISCOVER GALAXY BUILDING BLOCK

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This NASA Hubble Space Telescope image shows a very small, faint galaxy 'building block' newly discovered by a unique collaboration between ground- and space-based telescopes. Hubble and the 10-meter Keck Telescopes in Hawaii joined forces, using a galaxy cluster which acts as gravitational lens to detect what scientists believe is one of the smallest very distant objects ever found. The galaxy cluster Abell 2218 was used by a team of European and American astronomers led by Richard Ellis (Caltech) in their systematic search for intrinsically faint distant star-forming systems. Without help from Abell 2218's exceptional magnifying power to make objects appear about 30 times brighter, the galaxy building block would have been undetectable. In the image to the right, the object is seen distorted into two nearly identical, very red 'images' by the gravitational lens. The image pair represents the magnified result of a single background object gravitationally lensed by Abell 2218 and viewed at a distance of 13.4 billion light-years. The intriguing object contains only one million stars, far fewer than a mature galaxy, and scientists believe it is very young. Such young star-forming systems of low mass at early cosmic times are likely to be the objects from which present-day galaxies have formed. In the image to the left, the full overview of the galaxy cluster Abell 2218 is seen. This image was taken by Hubble in 1999 at the completion of Hubble Servicing Mission 3A. Credit: NASA, ESA, Richard Ellis (Caltech) and Jean-Paul Kneib (Observatoire Midi-Pyrenees, France) Acknowledgment: NASA, A. Fruchter and the ERO Team (STScI and ST-ECF)

  16. Health Fitness Standards. Aerobic Endurance.

    ERIC Educational Resources Information Center

    Dotson, Chuck

    1988-01-01

    An exploration of the current thinking about levels of fitness necessary to meet health fitness standards, with particular focus on aerobic capacity, discusses major health problems, the prevalence of heart disease, how health standards are set, and how health habits change as people age. (CB)

  17. Value of a newly sequenced bacterial genome

    PubMed Central

    Barbosa, Eudes GV; Aburjaile, Flavia F; Ramos, Rommel TJ; Carneiro, Adriana R; Le Loir, Yves; Baumbach, Jan; Miyoshi, Anderson; Silva, Artur; Azevedo, Vasco

    2014-01-01

    Next-generation sequencing (NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft (partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the “scientific value” of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. PMID:24921006

  18. Arthritis and Aerobic Exercise: A Review.

    ERIC Educational Resources Information Center

    Ike, Robert W.; And Others

    1989-01-01

    Arthritic patients who regularly do aerobic exercise make significant gains in aerobic and functional status, and in subjective areas like pain tolerance and mood. Still, they are often advised to curtail physical activity. Guidelines are presented for physicians prescribing aerobic exercise. An exercise tolerance test is recommended. (SM)

  19. Arthritis and Aerobic Exercise: A Review.

    ERIC Educational Resources Information Center

    Ike, Robert W.; And Others

    1989-01-01

    Arthritic patients who regularly do aerobic exercise make significant gains in aerobic and functional status, and in subjective areas like pain tolerance and mood. Still, they are often advised to curtail physical activity. Guidelines are presented for physicians prescribing aerobic exercise. An exercise tolerance test is recommended. (SM)

  20. A broad-scale comparison of aerobic activity levels in vertebrates: endotherms versus ectotherms.

    PubMed

    Gillooly, James F; Gomez, Juan Pablo; Mavrodiev, Evgeny V

    2017-02-22

    Differences in the limits and range of aerobic activity levels between endotherms and ectotherms remain poorly understood, though such differences help explain basic differences in species' lifestyles (e.g. movement patterns, feeding modes, and interaction rates). We compare the limits and range of aerobic activity in endotherms (birds and mammals) and ectotherms (fishes, reptiles, and amphibians) by evaluating the body mass-dependence of VO2 max, aerobic scope, and heart mass in a phylogenetic context based on a newly constructed vertebrate supertree. Contrary to previous work, results show no significant differences in the body mass scaling of minimum and maximum oxygen consumption rates with body mass within endotherms or ectotherms. For a given body mass, resting rates and maximum rates were 24-fold and 30-fold lower, respectively, in ectotherms than endotherms. Factorial aerobic scope ranged from five to eight in both groups, with scope in endotherms showing a modest body mass-dependence. Finally, maximum consumption rates and aerobic scope were positively correlated with residual heart mass. Together, these results quantify similarities and differences in the potential for aerobic activity among ectotherms and endotherms from diverse environments. They provide insights into the models and mechanisms that may underlie the body mass-dependence of oxygen consumption. © 2017 The Author(s).

  1. Temperate Lakes Discovered on Titan

    NASA Astrophysics Data System (ADS)

    Vixie, Graham; Barnes, Jason W.; Jackson, Brian; Wilson, Paul

    2012-04-01

    We have discovered two temperate lakes on Titan using Cassini's Visual and Infrared Mapping Spectrometer (VIMS). Three key features help to identify these surface features as lakes: morphology, albedo, and specular reflection. The presence of lakes at the mid-latitudes mean liquid can accumulate and remain stable outside of the poles. We first identify a lake surface by looking for possible shorelines with a lacustrine morphology. Then, we apply a simple atmospheric correction that produces an approximate surface albedo. Next, we prepare cylindrical projection maps of the brightness of the sky as seen from any points on the surface to identify specular reflections. Our techniques can then be applied to other areas, such as Arrakis Planitia, to test for liquid. Currently, all the known lakes on Titan are concentrated at the poles. Lakes have been suggested in the tropic zone by Griffith et al. Our discovery of non-transient, temperate lakes has important implications for Titan's hydrologic cycle. Clouds have been recorded accumulating in the mid-latitudes and areas have been darkened by rainfall but later brightened after evaporation (Turtle et al. 2011). Stable temperate lakes would affect total rainfall, liquid accumulation, evaporation rates, and infiltration. Polaznik Macula (Figure 1) is a great candidate for lake filling, evaporation rates, and stability. References: Griffith, C., et al.: "Evidence for Lakes on Titan's Tropical Surface". AAS/Division for Planetary Sciences Meeting Abstracts #42, Vol. 42, pp. 1077, 2010. Turtle, E. P., et al.: "Rapid and Extensive Surface Changes Near Titan's Equator: Evidence of April Showers". Science, Vol. 331, pp. 1414-, 2011. Figure 1: Polaznik Macula is the large, dark area central to the figure. The encircled dark blue areas represent positively identified lake regions in the T66 flyby. The light blue areas represent lake candidates still under analysis. The green circle marks a non-lake surface feature enclosed by a

  2. Glowing Hot Transiting Exoplanet Discovered

    NASA Astrophysics Data System (ADS)

    2003-04-01

    VLT Spectra Indicate Shortest-Known-Period Planet Orbiting OGLE-TR-3 Summary More than 100 exoplanets in orbit around stars other than the Sun have been found so far. But while their orbital periods and distances from their central stars are well known, their true masses cannot be determined with certainty, only lower limits. This fundamental limitation is inherent in the common observational method to discover exoplanets - the measurements of small and regular changes in the central star's velocity, caused by the planet's gravitational pull as it orbits the star. However, in two cases so far, it has been found that the exoplanet's orbit happens to be positioned in such a way that the planet moves in front of the stellar disk, as seen from the Earth. This "transit" event causes a small and temporary dip in the star's brightness, as the planet covers a small part of its surface, which can be observed. The additional knowledge of the spatial orientation of the planetary orbit then permits a direct determination of the planet's true mass. Now, a group of German astronomers [1] have found a third star in which a planet, somewhat larger than Jupiter, but only half as massive, moves in front of the central star every 28.5 hours . The crucial observation of this solar-type star, designated OGLE-TR-3 [2] was made with the high-dispersion UVES spectrograph on the Very Large Telescope (VLT) at the ESO Paranal Observatory (Chile). It is the exoplanet with the shortest period found so far and it is very close to the star, only 3.5 million km away. The hemisphere that faces the star must be extremely hot, about 2000 °C and the planet is obviously losing its atmosphere at high rate . PR Photo 10a/03 : The star OGLE-TR-3 . PR Photo 10b/03 : VLT UVES spectrum of OGLE-TR-3. PR Photo 10c/03 : Relation between stellar brightness and velocity (diagram). PR Photo 10d/03 : Observed velocity variation of OGLE-TR-3. PR Photo 10e/03 : Observed brightness variation of OGLE-TR-3. The search

  3. Aerobic microbial enhanced oil recovery

    SciTech Connect

    Torsvik, T.; Gilje, E.; Sunde, E.

    1995-12-31

    In aerobic MEOR, the ability of oil-degrading bacteria to mobilize oil is used to increase oil recovery. In this process, oxygen and mineral nutrients are injected into the oil reservoir in order to stimulate growth of aerobic oil-degrading bacteria in the reservoir. Experiments carried out in a model sandstone with stock tank oil and bacteria isolated from offshore wells showed that residual oil saturation was lowered from 27% to 3%. The process was time dependent, not pore volume dependent. During MEOR flooding, the relative permeability of water was lowered. Oxygen and active bacteria were needed for the process to take place. Maximum efficiency was reached at low oxygen concentrations, approximately 1 mg O{sub 2}/liter.

  4. Calcium precipitate induced aerobic granulation.

    PubMed

    Wan, Chunli; Lee, Duu-Jong; Yang, Xue; Wang, Yayi; Wang, Xingzu; Liu, Xiang

    2015-01-01

    Aerobic granulation is a novel biotechnology for wastewater treatment. This study refined existing aerobic granulation mechanisms as a sequencing process including formation of calcium precipitate under alkaline pH to form inorganic cores, followed by bacterial attachment and growth on these cores to form the exopolysaccharide matrix. Mature granules comprised an inner core and a matrix layer and a rim layer with enriched microbial strains. The inorganic core was a mix of different crystals of calcium and phosphates. Functional strains including Sphingomonas sp., Paracoccus sp. Sinorhizobium americanum strain and Flavobacterium sp. attached onto the cores. These functional strains promote c-di-GMP production and the expression by Psl and Alg genes for exopolysaccharide production to enhance formation of mature granules.

  5. WWOX loss activates aerobic glycolysis.

    PubMed

    Abu-Remaileh, Muhannad; Seewaldt, Victoria L; Aqeilan, Rami I

    2015-01-01

    Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

  6. WWOX loss activates aerobic glycolysis

    PubMed Central

    Abu-Remaileh, Muhannad; Seewaldt, Victoria L; Aqeilan, Rami I

    2015-01-01

    Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state. PMID:27308416

  7. Aerobic Metabolism of Streptococcus agalactiae

    PubMed Central

    Mickelson, M. N.

    1967-01-01

    Streptococcus agalactiae cultures possess an aerobic pathway for glucose oxidation that is strongly inhibited by cyanide. The products of glucose oxidation by aerobically grown cells of S. agalactiae 50 are lactic and acetic acids, acetylmethylcarbinol, and carbon dioxide. Glucose degradation products by aerobically grown cells, as percentage of glucose carbon, were 52 to 61% lactic acid, 20 to 23% acetic acid, 5.5 to 6.5% acetylmethylcarbinol, and 14 to 16% carbon dioxide. There was no evidence for a pentose cycle or a tricarboxylic acid cycle. Crude cell-free extracts of S. agalactiae 50 possessed a strong reduced nicotinamide adenine dinucleotide (NADH2) oxidase that is also cyanide-sensitive. Dialysis or ultrafiltration of the crude, cell-free extract resulted in loss of NADH2 oxidase activity. Oxidase activity was restored to the inactive extract by addition of the ultrafiltrate or by addition of menadione or K3Fe(CN)6. Noncytochrome iron-containing pigments were present in cell-free extracts of S. agalactiae. The possible participation of these pigments in the respiration of S. agalactiae is presently being studied. PMID:4291090

  8. Discovering Mobile Social Networks by Semantic Technologies

    NASA Astrophysics Data System (ADS)

    Jung, Jason J.; Choi, Kwang Sun; Park, Sung Hyuk

    It has been important for telecommunication companies to discover social networks from mobile subscribers. They have attempted to provide a number of recommendation services, but they realized that the services were not successful. In this chapter, we present semantic technologies for discovering social networks. The process is mainly composed of two steps; (1) profile identification and (2) context understanding. Through developing a Next generation Contents dElivery (NICE) platform, we were able to generate various services based on the discovered social networks.

  9. Astronomers Discover Fastest-Spinning Pulsar

    NASA Astrophysics Data System (ADS)

    2006-01-01

    Astronomers using the National Science Foundation's Robert C. Byrd Green Bank Telescope have discovered the fastest-spinning neutron star ever found, a 20-mile-diameter superdense pulsar whirling faster than the blades of a kitchen blender. Their work yields important new information about the nature of one of the most exotic forms of matter known in the Universe. Pulsar Graphic Pulsars Are Spinning Neutron Stars CREDIT: Bill Saxton, NRAO/AUI/NSF (Click on image for larger version) "We believe that the matter in neutron stars is denser than an atomic nucleus, but it is unclear by how much. Our observations of such a rapidly rotating star set a hard upper limit on its size, and hence on how dense the star can be.," said Jason Hessels, a graduate student at McGill University in Montreal. Hessels and his colleagues presented their findings to the American Astronomical Society's meeting in Washington, DC. Pulsars are spinning neutron stars that sling "lighthouse beams" of radio waves or light around as they spin. A neutron star is what is left after a massive star explodes at the end of its "normal" life. With no nuclear fuel left to produce energy to offset the stellar remnant's weight, its material is compressed to extreme densities. The pressure squeezes together most of its protons and electrons to form neutrons; hence, the name "neutron star." "Neutron stars are incredible laboratories for learning about the physics of the fundamental particles of nature, and this pulsar has given us an important new limit," explained Scott Ransom, an astronomer at the National Radio Astronomy Observatory and one of Hessels' collaborators on this work. The scientists discovered the pulsar, named PSR J1748-2446ad, in a globular cluster of stars called Terzan 5, located some 28,000 light-years from Earth in the constellation Sagittarius. The newly-discovered pulsar is spinning 716 times per second, or at 716 Hertz (Hz), readily beating the previous record of 642 Hz from a pulsar

  10. Copper-catalyzed aerobic oxidative cleavage of C-C bonds in epoxides leading to aryl nitriles and aryl aldehydes.

    PubMed

    Gu, Lijun; Jin, Cheng

    2015-04-18

    Novel copper-catalyzed aerobic synthesis of aryl nitriles and aldehydes from epoxides via C-C single bond cleavage has been discovered. This reaction provides a practical method toward the synthesis of aryl nitriles and aldehydes, which are versatile intermediates and building blocks in organic synthesis.

  11. Trocara virus: a newly recognized Alphavirus (Togaviridae) isolated from mosquitoes in the Amazon Basin.

    PubMed

    Travassos da Rosa, A P; Turell, M J; Watts, D M; Powers, A M; Vasconcelos, P F; Jones, J W; Klein, T A; Dohm, D J; Shope, R E; Degallier, N; Popov, V L; Russell, K L; Weaver, S C; Guzman, H; Calampa, C; Brault, A C; Lemon, A P; Tesh, R B

    2001-01-01

    This report describes Trocara virus, a newly recognized member of the genus Alphavirus, that has been isolated from Aedes serratus mosquitoes collected at two widely separated sites in the Amazon Basin. Biological, antigenic and genetic characteristics of the new virus are given. Results of these studies indicate that Trocara virus is the first member of a newly discovered antigenic complex within the family Togaviridae genus Alphavirus. The public health and veterinary importance of Trocara virus is still unknown.

  12. Scientists Discover Sugar in Space

    NASA Astrophysics Data System (ADS)

    2000-06-01

    . Glycolaldehyde is a simpler molecular cousin to table sugar, the scientists say. The sugar molecule was detected in a large cloud of gas and dust some 26,000 light-years away, near the center of our Galaxy. Such clouds, often many light-years across, are the material from which new stars are formed. Though very rarified by Earth standards, these interstellar clouds are the sites of complex chemical reactions that occur over hundreds of thousands or millions of years. So far, about 120 different molecules have been discovered in these clouds. Most of these molecules contain a small number of atoms, and only a few molecules with eight or more atoms have been found in interstellar clouds. The 12 Meter Telescope "Finding glycolaldehyde in one of these interstellar clouds means that such molecules can be formed even in very rarified conditions," said Hollis. "We don't yet understand how it could be formed there," he added. "A combination of more astronomical observations and theoretical chemistry work will be required to resolve the mystery of how this molecule is formed in space." "We hope this discovery inspires renewed efforts to find even more kinds of molecules, so that, with a better idea of the total picture, we may be able to deduce the details of the prebiotic chemistry taking place in interstellar clouds," Hollis said. The discovery was made by detecting faint radio emission from the sugar molecules in the interstellar cloud. Molecules rotate end-for-end, and as they change from one rotational energy state to another, they emit radio waves at precise frequencies. The "family" of radio frequencies emitted by a particular molecule forms a unique "fingerprint" that scientists can use to identify that molecule. The scientists identified glycolaldehyde by detecting six frequencies of radio emission in what is termed the millimeter-wavelength region of the electromagnetic spectrum -- a region between more-familiar microwaves and infrared radiation. The NRAO 12 Meter Telescope

  13. DISCOVER in Lebanon: A Pilot Study

    ERIC Educational Resources Information Center

    Sarouphim, Ketty M.

    2007-01-01

    The purpose of this study was to investigate the effectiveness of DISCOVER, a performance-based assessment, in identifying gifted students in Lebanon. DISCOVER is grounded in Gardner's MI theory and consists of tasks involving problem-solving and creative abilities. The sample consisted of 49 middle-class 5-th graders, with a mean age of 10.2…

  14. Regional aerobic glycolysis in the human brain

    PubMed Central

    Vaishnavi, S. Neil; Vlassenko, Andrei G.; Rundle, Melissa M.; Snyder, Abraham Z.; Mintun, Mark A.; Raichle, Marcus E.

    2010-01-01

    Aerobic glycolysis is defined as glucose utilization in excess of that used for oxidative phosphorylation despite sufficient oxygen to completely metabolize glucose to carbon dioxide and water. Aerobic glycolysis is present in the normal human brain at rest and increases locally during increased neuronal activity; yet its many biological functions have received scant attention because of a prevailing energy-centric focus on the role of glucose as substrate for oxidative phosphorylation. As an initial step in redressing this neglect, we measured the regional distribution of aerobic glycolysis with positron emission tomography in 33 neurologically normal young adults at rest. We show that the distribution of aerobic glycolysis in the brain is differentially present in previously well-described functional areas. In particular, aerobic glycolysis is significantly elevated in medial and lateral parietal and prefrontal cortices. In contrast, the cerebellum and medial temporal lobes have levels of aerobic glycolysis significantly below the brain mean. The levels of aerobic glycolysis are not strictly related to the levels of brain energy metabolism. For example, sensory cortices exhibit high metabolic rates for glucose and oxygen consumption but low rates of aerobic glycolysis. These striking regional variations in aerobic glycolysis in the normal human brain provide an opportunity to explore how brain systems differentially use the diverse cell biology of glucose in support of their functional specializations in health and disease. PMID:20837536

  15. Lower limb loading in step aerobic dance.

    PubMed

    Wu, H-W; Hsieh, H-M; Chang, Y-W; Wang, L-H

    2012-11-01

    Participation in aerobic dance is associated with a number of lower extremity injuries, and abnormal joint loading seems to be a factor in these. However, information on joint loading is limited. The purpose of this study was to investigate the kinetics of the lower extremity in step aerobic dance and to compare the differences of high-impact and low-impact step aerobic dance in 4 aerobic movements (mambo, kick, L step and leg curl). 18 subjects were recruited for this study. High-impact aerobic dance requires a significantly greater range of motion, joint force and joint moment than low-impact step aerobic dance. The peak joint forces and moments in high-impact step aerobic dance were found to be 1.4 times higher than in low-impact step aerobic dance. Understanding the nature of joint loading may help choreographers develop dance combinations that are less injury-prone. Furthermore, increased knowledge about joint loading may be helpful in lowering the risk of injuries in aerobic dance instructors and students.

  16. Astronomers Discover Spectacular Structure in Distant Galaxy

    NASA Astrophysics Data System (ADS)

    1999-01-01

    Researchers using the National Science Foundation's Very Large Array (VLA) radio telescope have imaged a "spectacular and complex structure" in a galaxy 50 million light-years away. Their work both resolves a decades-old observational mystery and revises current theories about the origin of X-ray emission coming from gas surrounding the galaxy. The new VLA image is of the galaxy M87, which harbors at its core a supermassive black hole spewing out jets of subatomic particles at nearly the speed of light and also is the central galaxy of the Virgo Cluster of galaxies. The VLA image is the first to show detail of a larger structure that originally was detected by radio astronomers more than a half-century ago. Analysis of the new image indicates that astronomers will have to revise their ideas about the physics of what causes X-ray emission in the cores of many galaxy clusters. Frazer Owen of the National Radio Astronomy Observatory (NRAO) in Socorro, NM; Jean Eilek of the New Mexico Institute of Mining and Technology (NM Tech) in Socorro, NM; and Namir Kassim of the Naval Research Laboratory in Washington, DC, announced their discovery at the American Astronomical Society's meeting today in Austin, TX. The new observations show two large, bubble-like lobes, more than 200,000 light-years across, that emit radio waves. These lobes, which are intricately detailed, apparently are powered by gravitational energy released from the black hole at the galaxy's center. "We think that material is flowing outward from the galaxy's core into these large, bright, radio-emitting 'bubbles,'" Owen said. The newly-discovered "bubbles" sit inside a region of the galaxy known to be emitting X-rays. Theorists have speculated that this X-ray emission arises when gas that originally was part of the Virgo Cluster of galaxies, cools and falls inwards onto M87 itself, at the center of the cluster. Such "cooling flows" are commonly thought to be responsible for strong X-ray emission in many

  17. Detailed Abundances of Stars with Small Planets Discovered by Kepler

    NASA Astrophysics Data System (ADS)

    Schuler, Simon C.; Vaz, Zachary A.; Katime Santrich, Orlando J.; Cunha, Katia M. L.; Smith, Verne V.; King, Jeremy R.; Ghezzi, Luan; Howell, Steve B.; Teske, Johanna

    2016-01-01

    We present newly derived stellar parameters and the detailed abundances of 19 elements of seven stars with small planets discovered by NASA's Kepler Mission. Each star save one has at least one planet with a radius less than 2 REarth, suggesting a primarily rocky composition. The stellar parameters and abundances are derived from high signal-to-noise ratio, high-resolution echelle spectroscopy obtained with the 10-m Keck I telescope and HIRES spectrometer using standard spectroscopic techniques. We compare the abundances to those of a general Galactic disk population and investigate possible abundance trends with condensation temperature of the elements.S.C.S. acknowledges support provided by grant NNX12AD19G to S.C.S. from the National Aeronautics and Space Administration as part of the Kepler Participating Scientist Program.

  18. Resistance to Aerobic Exercise Training Causes Metabolic Dysfunction and Reveals Novel Exercise-Regulated Signaling Networks

    PubMed Central

    Lessard, Sarah J.; Rivas, Donato A.; Alves-Wagner, Ana B.; Hirshman, Michael F.; Gallagher, Iain J.; Constantin-Teodosiu, Dumitru; Atkins, Ryan; Greenhaff, Paul L.; Qi, Nathan R.; Gustafsson, Thomas; Fielding, Roger A.; Timmons, James A.; Britton, Steven L.; Koch, Lauren G.; Goodyear, Laurie J.

    2013-01-01

    Low aerobic exercise capacity is a risk factor for diabetes and a strong predictor of mortality, yet some individuals are “exercise-resistant” and unable to improve exercise capacity through exercise training. To test the hypothesis that resistance to aerobic exercise training underlies metabolic disease risk, we used selective breeding for 15 generations to develop rat models of low and high aerobic response to training. Before exercise training, rats selected as low and high responders had similar exercise capacities. However, after 8 weeks of treadmill training, low responders failed to improve their exercise capacity, whereas high responders improved by 54%. Remarkably, low responders to aerobic training exhibited pronounced metabolic dysfunction characterized by insulin resistance and increased adiposity, demonstrating that the exercise-resistant phenotype segregates with disease risk. Low responders had impaired exercise-induced angiogenesis in muscle; however, mitochondrial capacity was intact and increased normally with exercise training, demonstrating that mitochondria are not limiting for aerobic adaptation or responsible for metabolic dysfunction in low responders. Low responders had increased stress/inflammatory signaling and altered transforming growth factor-β signaling, characterized by hyperphosphorylation of a novel exercise-regulated phosphorylation site on SMAD2. Using this powerful biological model system, we have discovered key pathways for low exercise training response that may represent novel targets for the treatment of metabolic disease. PMID:23610057

  19. Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks.

    PubMed

    Lessard, Sarah J; Rivas, Donato A; Alves-Wagner, Ana B; Hirshman, Michael F; Gallagher, Iain J; Constantin-Teodosiu, Dumitru; Atkins, Ryan; Greenhaff, Paul L; Qi, Nathan R; Gustafsson, Thomas; Fielding, Roger A; Timmons, James A; Britton, Steven L; Koch, Lauren G; Goodyear, Laurie J

    2013-08-01

    Low aerobic exercise capacity is a risk factor for diabetes and a strong predictor of mortality, yet some individuals are "exercise-resistant" and unable to improve exercise capacity through exercise training. To test the hypothesis that resistance to aerobic exercise training underlies metabolic disease risk, we used selective breeding for 15 generations to develop rat models of low and high aerobic response to training. Before exercise training, rats selected as low and high responders had similar exercise capacities. However, after 8 weeks of treadmill training, low responders failed to improve their exercise capacity, whereas high responders improved by 54%. Remarkably, low responders to aerobic training exhibited pronounced metabolic dysfunction characterized by insulin resistance and increased adiposity, demonstrating that the exercise-resistant phenotype segregates with disease risk. Low responders had impaired exercise-induced angiogenesis in muscle; however, mitochondrial capacity was intact and increased normally with exercise training, demonstrating that mitochondria are not limiting for aerobic adaptation or responsible for metabolic dysfunction in low responders. Low responders had increased stress/inflammatory signaling and altered transforming growth factor-β signaling, characterized by hyperphosphorylation of a novel exercise-regulated phosphorylation site on SMAD2. Using this powerful biological model system, we have discovered key pathways for low exercise training response that may represent novel targets for the treatment of metabolic disease.

  20. Aggression is associated with aerobic glycolysis in the honey bee brain(1).

    PubMed

    Chandrasekaran, S; Rittschof, C C; Djukovic, D; Gu, H; Raftery, D; Price, N D; Robinson, G E

    2015-02-01

    Aerobic glycolysis involves increased glycolysis and decreased oxidative catabolism of glucose even in the presence of an ample oxygen supply. Aerobic glycolysis, a common metabolic pattern in cancer cells, was recently discovered in both the healthy and diseased human brain, but its functional significance is not understood. This metabolic pattern in the brain is surprising because it results in decreased efficiency of adenosine triphosphate (ATP) production in a tissue with high energetic demands. We report that highly aggressive honey bees (Apis mellifera) show a brain transcriptomic and metabolic state consistent with aerobic glycolysis, i.e. increased glycolysis in combination with decreased oxidative phosphorylation. Furthermore, exposure to alarm pheromone, which provokes aggression, causes a metabolic shift to aerobic glycolysis in the bee brain. We hypothesize that this metabolic state, which is associated with altered neurotransmitter levels, increased glycolytically derived ATP and a reduced cellular redox state, may lead to increased neuronal excitability and oxidative stress in the brain. Our analysis provides evidence for a robust, distinct and persistent brain metabolic response to aggression-inducing social cues. This finding for the first time associates aerobic glycolysis with naturally occurring behavioral plasticity, which has important implications for understanding both healthy and diseased brain function. © 2015 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

  1. Aggression is associated with aerobic glycolysis in the honey bee brain1

    PubMed Central

    Chandrasekaran, S.; Rittschof, C. C.; Djukovic, D.; Gu, H.; Raftery, D.; Price, N. D.; Robinson, G. E.

    2015-01-01

    Aerobic glycolysis involves increased glycolysis and decreased oxidative catabolism of glucose even in the presence of an ample oxygen supply. Aerobic glycolysis, a common metabolic pattern in cancer cells, was recently discovered in both the healthy and diseased human brain, but its functional significance is not understood. This metabolic pattern in the brain is surprising because it results in decreased efficiency of adenosine triphosphate (ATP) production in a tissue with high energetic demands. We report that highly aggressive honey bees (Apis mellifera) show a brain transcriptomic and metabolic state consistent with aerobic glycolysis, i.e. increased glycolysis in combination with decreased oxidative phosphorylation. Furthermore, exposure to alarm pheromone, which provokes aggression, causes a metabolic shift to aerobic glycolysis in the bee brain. We hypothesize that this metabolic state, which is associated with altered neurotransmitter levels, increased glycolytically derived ATP and a reduced cellular redox state, may lead to increased neuronal excitability and oxidative stress in the brain. Our analysis provides evidence for a robust, distinct and persistent brain metabolic response to aggression-inducing social cues. This finding for the first time associates aerobic glycolysis with naturally occurring behavioral plasticity, which has important implications for understanding both healthy and diseased brain function. PMID:25640316

  2. Dive and discover: Expeditions to the seafloor

    NASA Astrophysics Data System (ADS)

    Ayers Lawrence, Lisa

    The Dive and Discover Web site is a virtual treasure chest of deep sea science and classroom resources. The goals of Dive and Discover are to engage students, teachers, and the general public in the excitement of ocean disco very through an interactive educational Web site. You can follow scientists on oceanographic research cruises by reading their daily cruise logs, viewing photos and video clips of the discoveries, and even e-mailing questions to the scientists and crew. WHOI has also included an "Educator's Companion" section with teaching strategies, activities, and assessments, making Dive and Discover an excellent resource for the classroom.

  3. Dive and discover: Expeditions to the seafloor

    NASA Astrophysics Data System (ADS)

    Lawrence, Lisa Ayers

    The Dive and Discover Web site is a virtual treasure chest of deep sea science and classroom resources. The goals of Dive and Discover are to engage students, teachers, and the general public in the excitement of ocean disco very through an interactive educational Web site. You can follow scientists on oceanographic research cruises by reading their daily cruise logs, viewing photos and video clips of the discoveries, and even e-mailing questions to the scientists and crew. WHOI has also included an “Educator's Companion” section with teaching strategies, activities, and assessments, making Dive and Discover an excellent resource for the classroom.

  4. Aerobic Fitness for the Moderately Retarded.

    ERIC Educational Resources Information Center

    Bauer, Dan

    1981-01-01

    Intended for physical education teachers, the booklet offers ideas for incorporating aerobic conditioning into programs for moderately mentally retarded students. An explanation of aerobic fitness and its benefits is followed by information on initiating a fitness program with evaluation of height, weight, body fat, resting heart rate, and…

  5. Aerobic rice mechanization: techniques for crop establishment

    NASA Astrophysics Data System (ADS)

    Khusairy, K. M.; Ayob, H.; Chan, C. S.; Fauzi, M. I. Mohamed; Mohamad Fakhrul, Z. O.; Shahril Shah, G. S. M.; Azlan, O.; Rasad, M. A.; Hashim, A. M.; Arshad, Z.; E, E. Ibrahim; Saifulizan, M. N.

    2015-12-01

    Rice being the staple food crops, hundreds of land races in it makes the diversity of rice crops. Aerobic rice production was introduced which requires much less water input to safeguard and sustain the rice production and conserve water due to decreasing water resources, climatic changes and competition from urban and industrial users. Mechanization system plays an important role for the success of aerobic rice cultivation. All farming activities for aerobic rice production are run on aerobic soil conditions. Row seeder mechanization system is developed to replace conventional seeding technique on the aerobic rice field. It is targeted for small and the large scale aerobic rice farmers. The aero - seeder machine is used for the small scale aerobic rice field, while the accord - seeder is used for the large scale aerobic rice field. The use of this mechanization machine can eliminate the tedious and inaccurate seeding operations reduce labour costs and increases work rate. The machine is easy to operate and it can increase crop establishment rate. It reduce missing hill, increasing planting and crop with high yield can be produce. This machine is designed for low costs maintenance and it is easy to dismantle and assemble during maintenance and it is safe to be used.

  6. Aerobic Dancing--A Rhythmic Sport.

    ERIC Educational Resources Information Center

    Sorensen, Jacki

    Fitness programs now and in the future must offer built-in cardiovascular conditioning, variety, novelty, and change to meet the physical, mental, and emotional needs of our society. Aerobic dancing (dancing designed to train and strengthen the heart, lungs, and vascular system) is one of the first indoor group Aerobic exercise programs designed…

  7. Skeletal Muscle Hypertrophy after Aerobic Exercise Training

    PubMed Central

    Konopka, Adam R.; Harber, Matthew P.

    2014-01-01

    Current dogma suggests aerobic exercise training has minimal effect on skeletal muscle size. We and others have demonstrated that aerobic exercise acutely and chronically alters protein metabolism and induces skeletal muscle hypertrophy. These findings promote an antithesis to the status quo by providing novel perspective on skeletal muscle mass regulation and insight into exercise-countermeasures for populations prone to muscle loss. PMID:24508740

  8. Aerobic Dancing--A Rhythmic Sport.

    ERIC Educational Resources Information Center

    Sorensen, Jacki

    Fitness programs now and in the future must offer built-in cardiovascular conditioning, variety, novelty, and change to meet the physical, mental, and emotional needs of our society. Aerobic dancing (dancing designed to train and strengthen the heart, lungs, and vascular system) is one of the first indoor group Aerobic exercise programs designed…

  9. Skeletal muscle hypertrophy after aerobic exercise training.

    PubMed

    Konopka, Adam R; Harber, Matthew P

    2014-04-01

    Current dogma suggests that aerobic exercise training has minimal effects on skeletal muscle size. We and others have demonstrated that aerobic exercise acutely and chronically alters protein metabolism and induces skeletal muscle hypertrophy. These findings promote an antithesis to the status quo by providing novel perspective on skeletal muscle mass regulation and insight into exercise countermeasures for populations prone to muscle loss.

  10. Computationally Driven, Quantitative Experiments Discover Genes Required for Mitochondrial Biogenesis

    PubMed Central

    Hess, David C.; Hayes, Alicia P.; Paw, Jadine; Clore, John J.; Mendoza, Rosa M.; Luis, Bryan San; Nislow, Corey; Giaever, Guri; Costanzo, Michael; Troyanskaya, Olga G.; Caudy, Amy A.

    2009-01-01

    Mitochondria are central to many cellular processes including respiration, ion homeostasis, and apoptosis. Using computational predictions combined with traditional quantitative experiments, we have identified 100 proteins whose deficiency alters mitochondrial biogenesis and inheritance in Saccharomyces cerevisiae. In addition, we used computational predictions to perform targeted double-mutant analysis detecting another nine genes with synthetic defects in mitochondrial biogenesis. This represents an increase of about 25% over previously known participants. Nearly half of these newly characterized proteins are conserved in mammals, including several orthologs known to be involved in human disease. Mutations in many of these genes demonstrate statistically significant mitochondrial transmission phenotypes more subtle than could be detected by traditional genetic screens or high-throughput techniques, and 47 have not been previously localized to mitochondria. We further characterized a subset of these genes using growth profiling and dual immunofluorescence, which identified genes specifically required for aerobic respiration and an uncharacterized cytoplasmic protein required for normal mitochondrial motility. Our results demonstrate that by leveraging computational analysis to direct quantitative experimental assays, we have characterized mutants with subtle mitochondrial defects whose phenotypes were undetected by high-throughput methods. PMID:19300474

  11. Scientists Discover More Clues to Stuttering

    MedlinePlus

    ... fullstory_162368.html Scientists Discover More Clues to Stuttering MRI shows involvement of brain areas controlling speech, ... speech, attention and emotion are all linked to stuttering. Stuttering is characterized by involuntarily repeating certain sounds, ...

  12. Discovering novel sequence motifs with MEME.

    PubMed

    Bailey, Timothy L

    2002-11-01

    This unit illustrates how to use MEME to discover motifs in a group of related nucleotide or peptide sequences. A MEME motif is a sequence pattern that occurs repeatedly in one or more sequences in the input group. MEME can be used to discover novel patterns because it bases its discoveries only on the input sequences, not on any prior knowledge (such as databases of known motifs). The input to MEME is a set of unaligned sequences of the same type (peptide or nucleotide). For each motif it discovers, MEME reports the occurrences (sites), consensus sequence, and the level of conservation (information content) at each position in the pattern. MEME also produces block diagrams showing where all of the discovered motifs occur in the training set sequences. MEME's hypertext (HTML) output also contains buttons that allow for the convenient use of the motifs in other searches.

  13. Kepler Discovers Earth-size Planet Candidates

    NASA Image and Video Library

    NASA's Kepler mission has discovered its first Earth-size planet candidates and its first candidates in the habitable zone, a region where liquid water could exist on a planet's surface. Five of th...

  14. Kepler Discovers Its First Rocky Planet

    NASA Image and Video Library

    NASA's Kepler mission confirmed the discovery of its first rocky planet, named Kepler-10b. Measuring 1.4 times the size of Earth, it is the smallest planet ever discovered outside our solar system....

  15. Fermi discovers giant bubbles in Milky Way

    NASA Image and Video Library

    Using data from NASA's Fermi Gamma-ray Space Telescope, scientists have recently discovered a gigantic, mysterious structure in our galaxy. This feature looks like a pair of bubbles extending above...

  16. Did the ancient egyptians discover Algol?

    NASA Astrophysics Data System (ADS)

    Jetsu, L.; Porceddu, S.; Porceddu, S.; Lyytinen, J.; Kajatkari, P.; Markkanen, T.; Toivari-Viitala, J.

    2013-02-01

    Fabritius discovered the first variable star, Mira, in 1596. Holwarda determined the 11 months period of Mira in 1638. Montanari discovered the next variable star, Algol, in 1669. Its period, 2.867 days, was determined by Goodricke (178). Algol was associated with demon-like creatures, "Gorgon" in ancient Greek and "ghoul" in ancient Arab mythology. This indicates that its variability was discovered much before 1669 (Wilk 1996), but this mythological evidence is ambiguous (Davis 1975). For thousands of years, the Ancient Egyptian Scribes (AES) observed stars for timekeeping in a region, where there are nearly 300 clear nights a year. We discovered a significant periodicity of 2.850 days in their calendar for lucky and unlucky days dated to 1224 BC, "the Cairo Calendar". Several astrophysical and astronomical tests supported our conclusion that this was the period of Algol three millennia ago. The "ghoulish habits" of Algol could explain this 0.017 days period increase (Battersby 2012).

  17. VLA Discovers Giant Rings Around Galaxy Cluster

    NASA Astrophysics Data System (ADS)

    2006-11-01

    Astronomers using the National Science Foundation's Very Large Array (VLA) radio telescope have discovered giant, ring-like structures around a cluster of galaxies. The discovery provides tantalizing new information about how such galaxy clusters are assembled, about magnetic fields in the vast spaces between galaxy clusters, and possibly about the origin of cosmic rays. Radio-Optical Image of Cluster Galaxy Cluster Abell 3376 (Radio/Optical) CREDIT: Joydeep Bagchi, IUCAA, NRAO/AUI/NSF Above, a combined radio/optical image shows the galaxy cluster Abell 3376 in visible light (blue) and radio (red) images. The giant radio arcs surrounding the cluster were discovered using the Very Large Array. The visible-light image is from the Digitized Sky survey. Below, an X-ray image of Abell 3376 made using the European Space Agency's XMM-Newton telescope shows a spectacular, bullet-shaped region of X-rays coming from gas heated to 60 million degrees Kelvin. The bullet shape results from the supersonic collision of a smaller smaller galaxy subcluster with the main body of the larger cluster. Click on images for larger version. X-Ray Image of Cluster Galaxy Cluster Abell 3376 (X-Ray) CREDIT: Joydeep Bagchi, IUCAA, ESA "These giant, radio-emitting rings probably are the result of shock waves caused by violent collisions of smaller groups of galaxies within the cluster," said Joydeep Bagchi, of the Inter-University Centre for Astronomy and Astrophysics in Pune, India, who led an international research team. The scientists reported their findings in the November 3 edition of the journal Science. The newly-discovered ring segments, some 6 million light-years across, surround a galaxy cluster called Abell 3376, more than 600 million light-years from Earth. They were revealed because fast-moving electrons emitted radio waves as they spiraled around magnetic field lines in intergalactic space. "Even from this large distance, the feeble radio waves were easily picked up by the VLA

  18. Aerobic glycolysis and lymphocyte transformation

    PubMed Central

    Hume, David A.; Radik, Judith L.; Ferber, Ernst; Weidemann, Maurice J.

    1978-01-01

    1. The role of enhanced aerobic glycolysis in the transformation of rat thymocytes by concanavalin A has been investigated. Concanavalin A addition doubled [U-14C]glucose uptake by rat thymocytes over 3h and caused an equivalent increased incorporation into protein, lipids and RNA. A disproportionately large percentage of the extra glucose taken up was converted into lactate, but concanavalin A also caused a specific increase in pyruvate oxidation, leading to an increase in the percentage contribution of glucose to the respiratory fuel. 2. Acetoacetate metabolism, which was not affected by concanavalin A, strongly suppressed pyruvate oxidation in the presence of [U-14C]glucose, but did not prevent the concanavalin A-induced stimulation of this process. Glucose uptake was not affected by acetoacetate in the presence or absence of concanavalin A, but in each case acetoacetate increased the percentage of glucose uptake accounted for by lactate production. 3. [3H]Thymidine incorporation into DNA in concanavalin A-treated thymocyte cultures was sensitive to the glucose concentration in the medium in a biphasic manner. Very low concentrations of glucose (25μm) stimulated DNA synthesis half-maximally, but maximum [3H]thymidine incorporation was observed only when the glucose concentration was raised to 1mm. Lactate addition did not alter the sensitivity of [3H]-thymidine uptake to glucose, but inosine blocked the effect of added glucose and strongly inhibited DNA synthesis. 4. It is suggested that the major function of enhanced aerobic glycolysis in transforming lymphocytes is to maintain higher steady-state amounts of glycolytic intermediates to act as precursors for macromolecule synthesis. PMID:310305

  19. Aerobic scope in chicken embryos.

    PubMed

    Ide, Satoko T; Ide, Ryoji; Mortola, Jacopo P

    2017-10-01

    We investigated the aerobic scope of chicken embryos, that is, the margin of increase of oxygen consumption ( [Formula: see text] ) above its normal value. [Formula: see text] was measured by an open-flow methodology at embryonic ages E3, E7, E11, E15, E19 and at E20 at the internal (IP) and external pipping (EP) phases, at the normal incubation temperature (Ta=38°C), in hypothermia (Ta=30°C) and in hyperthermia (Ta=41 and 44°C). In the cold, Q10 averaged ~2 at all ages, except in IP and EP when lower values (~1.5) indicated some degree of thermogenesis. In hyperthermia (38-44°C) Q10 was between 1 and 1.4. Hyperthermia had no significant effects on [Formula: see text] whether the results combined all ages or considered individual age groups, except in IP (in which [Formula: see text] increased 8% with 44°C) and EP embryos (+13%). After opening the air cell, which exposed the embryo to a higher O2 pressure, hyperthermic [Formula: see text] was significantly higher than in normothermia in E19 (+13%), IP (+22%) and EP embryos (+22%). We conclude that in chicken embryos throughout most of incubation neither heat nor oxygen availability limits the normal (normoxic-normothermic) values of [Formula: see text] . Only close to hatching O2-diffusion represents a limiting factor to the embryo's [Formula: see text] . Hence, embryos differ from postnatal animals for a nearly absent aerobic scope, presumably because their major sources of energy expenditure (growth and tissue maintenance) are constantly maximized. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Aerobic fitness testing: an update.

    PubMed

    Stevens, N; Sykes, K

    1996-12-01

    This study confirms that all three tests are reliable tools for the assessment of cardiorespiratory fitness and the prediction of aerobic capacity. While this particular study consisted of active, youthful subjects, subsequent studies at University College Chester have found similar findings with larger databases and a wider cross-section of subjects. The Astrand cycle test and Chester step test are submaximal tests with error margins of 5-15 per cent and therefore, not as precise as maximal testing. However, they still give a reasonably accurate reflection of an individual's fitness without the cost, time, effort and risk on the part of the subject. The bleep test is a low-cost maximal test designed for well-motivated, active individuals who are used to running to physical exhaustion. Used on other groups, results will not accurately reflect cardiorespiratory fitness values. While all three tests have inherent advantages and disadvantages, perhaps the most important factors are the knowledge and skills of the tester. Without a sound understanding of the physiological principles underlying these tests, and the ability to conduct an accurate assessment and evaluation of results in a knowledgeable and meaningful way, then the credibility of the tests and the results become suspect. However, used correctly, aerobic capacity tests can provide valuable baseline data about the fitness levels of individuals and data from which exercise programmes may be developed. The tests also enable fitness improvements to be monitored, help to motivate participants by establishing reasonable and achievable goals, assist in risk stratification and facilitate participants' education about the importance of physical fitness for work and for life. Since this study was completed, further tests have been repeated on 140 subjects of a wider age and ability range. This large database confirms the results found in this study.

  1. A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women.

    PubMed

    Kraemer, R R; Shockett, P; Webb, N D; Shah, U; Castracane, V D

    2014-02-01

    Irisin, a newly discovered, PGC-1α dependent myokine, has recently been shown to increase in circulation in response to sprint exercise. This study examined the effect of prolonged exercise on irisin concentrations in young men (n=7) as well as in young women (n=5) during different stages of the menstrual cycle. Seven young men completed 90 min of treadmill exercise at 60% of VO2max and a resting control trial. Five women completed the same exercise protocol in two different trials: during the early follicular phase and mid-luteal phase of the menstrual cycle. Blood samples were collected and analyzed for irisin concentrations immediately before exercise, at 54 and 90 min of exercise, and at 20 min of recovery (R20). Findings revealed that by 54 min of a 90 min treadmill exercise protocol at 60% of VO2max, irisin concentrations significantly increased 20.4% in young men and 20.3% as well as 24.6% in young women during the early follicular and mid-luteal phases of the menstrual cycle, respectively. However, by 90 min of exercise as well as R20, irisin concentrations were no longer elevated. Stage of the menstrual cycle did not affect responses in young women. Findings indicate that prolonged aerobic exercise produces a transient increase in irisin concentrations during the first hour of exercise for both genders and suggest that this form of moderate exercise may be helpful in improving fat metabolism.

  2. Fit women are not able to use the whole aerobic capacity during aerobic dance.

    PubMed

    Edvardsen, Elisabeth; Ingjer, Frank; Bø, Kari

    2011-12-01

    Edvardsen, E, Ingjer, F, and Bø, K. Fit women are not able to use the whole aerobic capacity during aerobic dance. J Strength Cond Res 25(12): 3479-3485, 2011-This study compared the aerobic capacity during maximal aerobic dance and treadmill running in fit women. Thirteen well-trained female aerobic dance instructors aged 30 ± 8.17 years (mean ± SD) exercised to exhaustion by running on a treadmill for measurement of maximal oxygen uptake (VO(2)max) and peak heart rate (HRpeak). Additionally, all subjects performed aerobic dancing until exhaustion after a choreographed videotaped routine trying to reach the same HRpeak as during maximal running. The p value for statistical significance between running and aerobic dance was set to ≤0.05. The results (mean ± SD) showed a lower VO(2)max in aerobic dance (52.2 ± 4.02 ml·kg·min) compared with treadmill running (55.9 ± 5.03 ml·kg·min) (p = 0.0003). Further, the mean ± SD HRpeak was 182 ± 9.15 b·min in aerobic dance and 192 ± 9.62 b·min in treadmill running, giving no difference in oxygen pulse between the 2 exercise forms (p = 0.32). There was no difference in peak ventilation (aerobic dance: 108 ± 10.81 L·min vs. running: 113 ± 11.49 L·min). In conclusion, aerobic dance does not seem to be able to use the whole aerobic capacity as in running. For well endurance-trained women, this may result in a lower total workload at maximal intensities. Aerobic dance may therefore not be as suitable as running during maximal intensities in well-trained females.

  3. Aerobic granular processes: Current research trends.

    PubMed

    Zhang, Quanguo; Hu, Jianjun; Lee, Duu-Jong

    2016-06-01

    Aerobic granules are large biological aggregates with compact interiors that can be used in efficient wastewater treatment. This mini-review presents new researches on the development of aerobic granular processes, extended treatments for complicated pollutants, granulation mechanisms and enhancements of granule stability in long-term operation or storage, and the reuse of waste biomass as renewable resources. A discussion on the challenges of, and prospects for, the commercialization of aerobic granular process is provided. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Five new outbursting AM CVn systems discovered by the Palomar Transient Factory

    NASA Astrophysics Data System (ADS)

    Levitan, David; Kupfer, Thomas; Groot, Paul J.; Kulkarni, Shrinivas R.; Prince, Thomas A.; Simonian, Gregory V.; Arcavi, Iair; Bloom, Joshua S.; Laher, Russ; Nugent, Peter E.; Ofek, Eran O.; Sesar, Branimir; Surace, Jason

    2013-04-01

    We present five new outbursting AM CVn systems and one candidate discovered as part of an ongoing search for such systems using the Palomar Transient Factory (PTF). This is the first large-area, systematic search for AM CVn systems using only large-amplitude photometric variability to select candidates. Three of the confirmed systems and the candidate system were discovered as part of the PTF transient search. Two systems were found as part of a search for outbursts through the PTF photometric data base. We discuss the observed characteristics of each of these systems, including the orbital periods of two systems. We also consider the position of these systems, selected in a colour-independent survey, in colour-colour space and compare to systems selected solely by their colours. We find that the colours of our newly discovered systems do not differ significantly from those of previously known systems, but significant errors preclude a definitive answer.

  5. Do patients with newly diagnosed type 2 diabetes have impaired physical fitness, and energy expenditures?

    PubMed

    Ucok, K; Yalcinkaya, H; Acay, A; Coban, N F; Aslanalp, S; Akkan, G; Aydin, S; Celikagi, C; Ahsen, A

    2015-07-01

    The disease-related components such as physical fitness and daily energy expenditure may change in each progressive period of type 2 diabetes. The purpose of this study was to compare the maximal aerobic capacity (VO2 max), muscle strength, trunk flexibility, total energy expenditure, daily physical activity, resting metabolic rate (RMR), body composition, and body fat distribution in newly diagnosed type 2 diabetic patients with those of healthy controls. Eighty patients (40 male, 40 female) with type 2 diabetes and 80 (40 male, 40 female) controls were included in this study. All participants completed the measurements. It was determined that the VO2 max, muscle strength, daily number of steps, and total energy expenditure were lower, and the body fat percentage, and central obesity were higher in male and female type 2 diabetic patients, when compared with the controls. In addition, the lean body mass was decreased in male diabetic patients, compared with the controls. The fasting plasma glucose showed negative correlations with the maximal aerobic capacity, daily number of steps, and muscle strength in the patients in both genders. RMR and trunk flexibility values were not significantly different between the patients and the controls in either gender. We suggest that using exercise intervention especially comprised of strength training and aerobic activities, including not only daily slow activities but also moderate to vigorous activities, as a lifestyle modification in newly diagnosed type 2 diabetic patients might be helpful for the development of earlier and more successful illness management strategies.

  6. The effects of aerobic training on children's creativity, self-perception, and aerobic power.

    PubMed

    Herman-Tofler, L R; Tuckman, B W

    1998-10-01

    The article examines whether participation in an aerobic exercise program (AE), as compared with a traditional physical education class (PE), significantly increased children's perceived athletic competence, physical appearance, social acceptance, behavioral conduct, and global self-worth; increased their figural creativity; and improved aerobic power as measured by an 800-meter run around a track. Further research on the effects of different types of AE is discussed, as well as the need for aerobic conditioning in the elementary school.

  7. Molecular Outflows from Newly Formed Massive Stars

    NASA Astrophysics Data System (ADS)

    Kim, Kee-Tae; Kim, Won-Ju; Kim, Chang-Hee

    2015-12-01

    We map 6 massive young stellar objects (YSOs) in the CO J=2-1 line and survey 18 massive YSOs, including the six, in the hcopj, sioj, water 6_{16}-5_{23} maser, and methanol 7_{0}-6_{1} A^{+} maser lines. We detect CO bipolar outflows in all the six mapped sources. Four of them are newly discovered (ifive, ieight, inine, iten), while itwo is mapped in the CO J=2-1 line for the first time. The detected outflows are much more massive and energetic than outflows from low-mass YSOs with masses >20 M_⊙ and momenta >300 M_⊙ km/s. They have mass outflow rates (3-6)×10^{-4} M_⊙ yr^{-1}, which are at least one order of magnitude greater than those observed in low-mass YSOs. We detect hcop and SiO line emission in 18 (100%) and 4 (22%) sources, respectively. The hcop spectra show high-velocity wings in 11 (61%) sources. We detect water maser emission in 13 (72%) sources and 44 GHz methanol maser emission in 8 (44%) sources. Of the detected sources, 5 water and 6 methanol maser sources are new discoveries. iseven shows high-velocity (>30 kms) water maser lines. We find good correlations of the bolometric luminosity of the central (proto)star with the mechanical force, mechanical luminosity, and mass outflow rate of molecular outflow %L_{bol} with F_{m}, L_{m}, and dot{M}_{out} in the bolometric luminosity range of 10^{-1}-10^6 lsol, and identified 3 intermediate- or high-mass counterparts of Class O objects.

  8. The rise of oxygen and aerobic biochemistry.

    PubMed

    Saito, Mak A

    2012-01-11

    Analysis of conserved protein folding domains across extant genomes by Kim et al. in this issue of Structure provides insights into the timing of some of the earliest aerobic metabolisms to arise on Earth.

  9. The Energetics of Aerobic versus Anaerobic Respiration.

    ERIC Educational Resources Information Center

    Champion, Timothy D.; Schwenz, Richard W.

    1990-01-01

    Background information, laboratory procedures, and a discussion of the results of an experiment designed to investigate the difference in energy gained from the aerobic and anaerobic oxidation of glucose are presented. Sample experimental and calculated data are included. (CW)

  10. The Energetics of Aerobic versus Anaerobic Respiration.

    ERIC Educational Resources Information Center

    Champion, Timothy D.; Schwenz, Richard W.

    1990-01-01

    Background information, laboratory procedures, and a discussion of the results of an experiment designed to investigate the difference in energy gained from the aerobic and anaerobic oxidation of glucose are presented. Sample experimental and calculated data are included. (CW)

  11. Neuromodulation of Aerobic Exercise—A Review

    PubMed Central

    Heijnen, Saskia; Hommel, Bernhard; Kibele, Armin; Colzato, Lorenza S.

    2016-01-01

    Running, and aerobic exercise in general, is a physical activity that increasingly many people engage in but that also has become popular as a topic for scientific research. Here we review the available studies investigating whether and to which degree aerobic exercise modulates hormones, amino acids, and neurotransmitters levels. In general, it seems that factors such as genes, gender, training status, and hormonal status need to be taken into account to gain a better understanding of the neuromodular underpinnings of aerobic exercise. More research using longitudinal studies and considering individual differences is necessary to determine actual benefits. We suggest that, in order to succeed, aerobic exercise programs should include optimal periodization, prevent overtraining and be tailored to interindividual differences, including neuro-developmental and genetically-based factors. PMID:26779053

  12. Conditioning and Aerobics for Older Americans.

    ERIC Educational Resources Information Center

    Hansen, Joyce

    1980-01-01

    A class designed for the maintenance and gradual improvement of senior citizens' physical fitness includes relaxation training, flexibility and stretching exercises, interval training activities (designed as a link between less strenuous exercise and more strenuous activities), and aerobic exercises. (CJ)

  13. Aerobic catabolism of bile acids.

    PubMed Central

    Leppik, R A; Park, R J; Smith, M G

    1982-01-01

    Seventy-eight stable cultures obtained by enrichment on media containing ox bile or a single bile acid were able to utilize one or more bile acids, as well as components of ox bile, as primary carbon sources for growth. All isolates were obligate aerobes, and most (70) were typical (48) or atypical (22) Pseudomonas strains, the remainder (8) being gram-positive actinomycetes. Of six Pseudomonas isolates selected for further study, five produced predominantly acidic catabolites after growth on glycocholic acid, but the sixth, Pseudomonas sp. ATCC 31752, accumulated as the principal product a neutral steroid catabolite. Optimum growth of Pseudomonas sp. ATCC 31752 on ox bile occurred at pH 7 to 8 and from 25 to 30 degrees C. No additional nutrients were required to sustain good growth, but growth was stimulated by the addition of ammonium sulfate and yeast extract. Good growth was obtained with a bile solids content of 40 g/liter in shaken flasks. A near-theoretical yield of neutral steroid catabolites, comprising a major (greater than 50%) and three minor products, was obtained from fermentor growth of ATCC 31752 in 6.7 g of ox bile solids per liter. The possible commercial exploitation of these findings to produce steroid drug intermediates for the pharmaceutical industry is discussed. PMID:7149711

  14. Aerobic biodegradation of selected monoterpenes.

    PubMed

    Misra, G; Pavlostathis, S G; Perdue, E M; Araujo, R

    1996-07-01

    Batch experiments were conducted to assess the biotransformation potential of four hydrocarbon monoterpenes (d-limonene, alpha-pinene, gamma-terpinene, and terpinolene) and four alcohols (arbanol, linalool, plinol, and alpha-terpineol) under aerobic conditions at 23 degrees C. Both forest-soil extract and enriched cultures were used as inocula for the biodegradation experiments conducted first without, then with prior microbial acclimation to the monoterpenes tested. All four hydrocarbons and two alcohols were readily degraded. The increase in biomass and headspace CO2 concentrations paralleled the depletion of monoterpenes, thus confirming that terpene disappearance was the result of biodegradation accompanied by microbial growth and mineralization. Plinol resisted degradation in assays using inocula from diverse sources, while arbanol degraded very slowly. A significant fraction of d-limonene-derived carbon was accounted for as non-extractable, dissolved organic carbon, whereas terpineol exhibited a much higher degree of utilization. The rate and extent of monoterpene biodegradation were not significantly affected by the presence of dissolved natural organic matter.

  15. Boron Discovered in Ancient Habitable Mars Groundwater

    SciTech Connect

    Gasda, Patrick

    2016-12-13

    Boron was recently discovered in calcium-sulfate veins on Mars using the ChemCam instrument on NASA’s Curiosity Mars Rover. This is the first Mars mission to detect boron on the Red Planet. Los Alamos Post-Doctoral Student Patrick Gasda explains how this discovery helps us better understand the timescale of habitability on Mars.

  16. Discover Your Band or Orchestra's Roots.

    ERIC Educational Resources Information Center

    Fonder, Mark

    1990-01-01

    States that discovering the origins of one's school music group can promote interest in the school's music programs. Discusses books that provide historical information on school music programs; provides ideas for formulating teaching objectives; and tells how to locate sources and organize data. (DB)

  17. Discovering Science through Art-Based Activities

    ERIC Educational Resources Information Center

    Alberts, Rebecca

    2010-01-01

    Art and science are intrinsically linked; the essence of art and science is discovery. Both artists and scientists work in a systematic but creative way--knowledge and understanding are built up through pieces of art or a series of labs. In the classroom, integrating science and visual art can provide students with the latitude to think, discover,…

  18. Discovering Alaska's Salmon: A Children's Activity Book.

    ERIC Educational Resources Information Center

    Devaney, Laurel

    This children's activity book helps students discover Alaska's salmon. Information is provided about salmon and where they live. The salmon life cycle and food chains are also discussed. Different kinds of salmon such as Chum Salmon, Chinook Salmon, Coho Salmon, Sockeye Salmon, and Pink Salmon are introduced, and various activities on salmon are…

  19. Discovering Diabetes Complications: an Ontology Based Model

    PubMed Central

    Daghistani, Tahani; Shammari, Riyad Al; Razzak, Muhammad Imran

    2015-01-01

    Background: Diabetes is a serious disease that spread in the world dramatically. The diabetes patient has an average of risk to experience complications. Take advantage of recorded information to build ontology as information technology solution will help to predict patients who have average of risk level with certain complication. It is helpful to search and present patient’s history regarding different risk factors. Discovering diabetes complications could be useful to prevent or delay the complications. Method: We designed ontology based model, using adult diabetes patients’ data, to discover the rules of diabetes with its complications in disease to disease relationship. Result: Various rules between different risk factors of diabetes Patients and certain complications generated. Furthermore, new complications (diseases) might be discovered as new finding of this study, discovering diabetes complications could be useful to prevent or delay the complications. Conclusion: The system can identify the patients who are suffering from certain risk factors such as high body mass index (obesity) and starting controlling and maintaining plan. PMID:26862251

  20. Discovering the Sequential Structure of Thought

    ERIC Educational Resources Information Center

    Anderson, John R.; Fincham, Jon M.

    2014-01-01

    Multi-voxel pattern recognition techniques combined with Hidden Markov models can be used to discover the mental states that people go through in performing a task. The combined method identifies both the mental states and how their durations vary with experimental conditions. We apply this method to a task where participants solve novel…

  1. Discovering the Sequential Structure of Thought

    ERIC Educational Resources Information Center

    Anderson, John R.; Fincham, Jon M.

    2014-01-01

    Multi-voxel pattern recognition techniques combined with Hidden Markov models can be used to discover the mental states that people go through in performing a task. The combined method identifies both the mental states and how their durations vary with experimental conditions. We apply this method to a task where participants solve novel…

  2. Discovering English with the Sketch Engine

    ERIC Educational Resources Information Center

    Thomas, James

    2014-01-01

    "Discovering English with the Sketch Engine" is the title of a new book (Thomas, 2014) which introduces the use of corpora in language study, teaching, writing and translating. It focuses on using the Sketch Engine to identify patterns of normal usage in many aspects of English ranging from morphology to discourse and pragmatics. This…

  3. Pseudomonas blight discovered on raspberry in Watsonville

    USDA-ARS?s Scientific Manuscript database

    In the winter (February) of 2013, a field of raspberries in Watsonville was discovered to be infected with Pseudomonas syringae, the causal agent of Pseudomonas blight disease. This was the first documentation of this disease on raspberry in our region. The infection of raspberry plants is manifeste...

  4. Discover Presidential Log Cabins. Teacher's Discussion Guide.

    ERIC Educational Resources Information Center

    National Park Service (Dept. of Interior), Washington, DC.

    Discover Presidential Log Cabins is a set of materials designed to help educate 6-8 grade students about the significance of three log cabin sites occupied by George Washington, Ulysses Grant, Abraham Lincoln, and Theodore Roosevelt. This teacher's discussion guide is intended for use as part of a larger, comprehensive social studies program, and…

  5. MASTER: bright PSN discovered in Argentina

    NASA Astrophysics Data System (ADS)

    Shumkov, V.; Lipunov, V.; Podesta, R.; Levato, H.; Buckley, D.; Gorbovskoy, E.; Tiurina, N.; Balanutsa, P.; Kuznetsov, A.; Vladimirov, V.; Gress, O.; Ivanov, K.; Chazov, V.; Lopez, C.; Podesta, F.; Saffe, C.; Pogrosheva, T.; Shurpakov, S.

    2016-10-01

    MASTER-OAFA (located in Argentina) auto-detection system ( Lipunov et al., 2010, Advances in Astronomy, vol. 2010, 30L ) discovered OT source at (RA, Dec) = 22h 01m 01.36s -40d 15m 26.7s on 2016-10-31.08091 UT. The OT unfiltered magnitude is 16.9m (mlim=19.9m).

  6. Discovering Community: Activities for Afterschool Programs

    ERIC Educational Resources Information Center

    National Institute on Out-of-School Time, Wellesley College, 2006

    2006-01-01

    The project activities highlighted in this publication were conducted within the framework of school-based afterschool programs operated by community-based organizations. The intention of the Discovering Community initiative, created by The After-School Corporation and MetLife Foundation, is to foster greater collaborations and mutual respect…

  7. Television: A Medium for Discovering Diversity?

    ERIC Educational Resources Information Center

    Selva, Marta; Sola, Anna

    1995-01-01

    Examines television news programs as media for discovering diversity. Discusses television as a means of information and communication, its role in the creation of public opinion, its inability to permit understanding, and the need for empirical research to assess its influence on cognitive processes. (AEF)

  8. Discovering Alaska's Salmon: A Children's Activity Book.

    ERIC Educational Resources Information Center

    Devaney, Laurel

    This children's activity book helps students discover Alaska's salmon. Information is provided about salmon and where they live. The salmon life cycle and food chains are also discussed. Different kinds of salmon such as Chum Salmon, Chinook Salmon, Coho Salmon, Sockeye Salmon, and Pink Salmon are introduced, and various activities on salmon are…

  9. Did Viking discover life on Mars?

    NASA Technical Reports Server (NTRS)

    Klein, H. P.

    1999-01-01

    A major argument in the claim that life had been discovered during the Viking mission to Mars is that the results obtained in the Labeled Release (LR) experiment are analogous to those observed with terrestrial microorganisms. This assertion is critically examined and found to be implausible.

  10. Discovering Integration through a Physical Phenomenon

    ERIC Educational Resources Information Center

    Burt, Derek; Magnes, Jenny; Schwarz, Gregory; Hartke, John

    2008-01-01

    This article outlines a method of conducting a laboratory designed to discover mathematical integration with students. The results are produced and verified in the laboratory by students. Understanding that an integral is defined by the area bounded by a function of x and the x-axis from a point a to a point b is challenging. Students often have…

  11. Did Viking discover life on Mars?

    PubMed

    Klein, H P

    1999-12-01

    A major argument in the claim that life had been discovered during the Viking mission to Mars is that the results obtained in the Labeled Release (LR) experiment are analogous to those observed with terrestrial microorganisms. This assertion is critically examined and found to be implausible.

  12. New volcanoes discovered in southeast Australia

    NASA Astrophysics Data System (ADS)

    Wendel, JoAnna

    2014-07-01

    Scientists have discovered three new active volcanoes in the Newer Volcanics Province (NVP) in southeast Australia. Researchers from Monash University in Melbourne describe in the Australian Journal of Earth Sciences how they used a combination of satellite photographs, detailed topography models from NASA, the distribution of magnetic minerals in the rocks, and site visits to analyze the region.

  13. Did Viking discover life on Mars?

    NASA Technical Reports Server (NTRS)

    Klein, H. P.

    1999-01-01

    A major argument in the claim that life had been discovered during the Viking mission to Mars is that the results obtained in the Labeled Release (LR) experiment are analogous to those observed with terrestrial microorganisms. This assertion is critically examined and found to be implausible.

  14. Effect of long term anaerobic and intermittent anaerobic/aerobic starvation on aerobic granules.

    PubMed

    Pijuan, Maite; Werner, Ursula; Yuan, Zhiguo

    2009-08-01

    The effect of long term anaerobic and intermittent anaerobic/aerobic starvation on the structure and activity of aerobic granules was studied. Aerobic granular sludge treating abattoir wastewater and achieving high levels of nutrient removal was subjected to 4-5 week starvation under anaerobic and intermittent anaerobic/aerobic conditions. Microscopic pictures of granules at the beginning of the starvation period presented a round and compact surface morphology with a much defined external perimeter. Under both starvation conditions, the morphology changed at the end of starvation with the external border of the granules surrounded by floppy materials. The loss of granular compactness was faster and more pronounced under anaerobic/aerobic starvation conditions. The release of Ca(2+) at the onset of anaerobic/aerobic starvation suggests a degradation of extracellular polymeric substances. The activity of ammonia oxidizing bacteria was reduced by 20 and 36% during anaerobic and intermittent anaerobic/aerobic starvation, respectively. When fresh wastewater was reintroduced, the granules recovered their initial morphology within 1 week of normal operation and the nutrient removal activity recovered fully in 3 weeks. The results show that both anaerobic and intermittent anaerobic/aerobic conditions are suitable for maintaining granule structure and activity during starvation.

  15. Aerobic Excercise and Research Opportunities to Benefit Impaired Children. (Project AEROBIC). Final Report.

    ERIC Educational Resources Information Center

    Idaho Univ., Moscow.

    The final report summarizes accomplishments of Project AEROBIC (Aerobic Exercise and Research Opportunities to Benefit Impaired Children), which provided a physical education exercise program for severely, profoundly, and multiply handicapped children aged 10-21. Activities are outlined for the 3 year period and include modification of exercise…

  16. Repeated-sprint ability and aerobic fitness.

    PubMed

    Thébault, Nicolas; Léger, Luc A; Passelergue, Philippe

    2011-10-01

    The purpose of this study was to reinvestigate the relationship between aerobic fitness and fatigue indices of repeated-sprint ability (RSA), with special attention to methodological normalization. Soldiers were divided into low (n = 10) and high (n = 9) fitness groups according to a preset maximal aerobic speed (MAS) of 17 km·h(-1) (∼60 ml O2·kg(-1)·min) measured with the University of Montreal Track Test (UMTT). Subjects' assessment included the RSA test (3 sets of 5 40-m sprints with 1-minute rest between sprints and 1.5 minutes between sets), a 40-m sprint (criterion test used in the computation of fatigue indices for the RSA test), strength and power measurement of the lower limbs, and the 20-m shuttle run test (20-m SRT) and the UMTT, which are measures of maximal aerobic power. The highest correlation with the RSA fatigue indices was obtained with the 20-m SRT (r = 0.90, p = 0.0001, n = 19), a test with 180° direction changes and accelerations and decelerations. The lower correlation (r = 0.66, p < 0.01, n = 19) with the UMTT (continuous forward running) suggests that some aerobic tests better disclose the importance of aerobic fitness for RSA and that aerobic power is not the sole determinant of RSA. However, neither strength nor vertical jumping power was correlated to the RSA fatigue indices. Subjects with greater MAS were able to maintain almost constant level of speed throughout series of repeated sprints and achieved better recovery between series. A MAS of at least 17 km·h(-1) favors constant and high speed level during repeated sprints. From a practical point of view, a high aerobic fitness is a precious asset in counteracting fatigue in sports with numerous sprint repetitions.

  17. DISCOVERING HABITABLE EARTHS, HOT JUPITERS, AND OTHER CLOSE PLANETS WITH MICROLENSING

    SciTech Connect

    Di Stefano, R.

    2012-06-20

    Searches for planets via gravitational lensing have focused on cases in which the projected separation, a, between planet and star is comparable to the Einstein radius, R{sub E} . This paper considers smaller orbital separations and demonstrates that evidence of close-orbit planets can be found in the low-magnification portion of the light curves generated by the central star. We develop a protocol for discovering hot Jupiters as well as Neptune-mass and Earth-mass planets in the stellar habitable zone. When planets are not discovered, our method can be used to quantify the probability that the lens star does not have planets within specified ranges of the orbital separation and mass ratio. Nearby close-orbit planets discovered by lensing can be subject to follow-up observations to study the newly discovered planets or to discover other planets orbiting the same star. Careful study of the low-magnification portions of lensing light curves should produce, in addition to the discoveries of close-orbit planets, definite detections of wide-orbit planets through the discovery of 'repeating' lensing events. We show that events exhibiting extremely high magnification can effectively be probed for planets in close, intermediate, and wide distance regimes simply by adding several-time-per-night monitoring in the low-magnification wings, possibly leading to gravitational lensing discoveries of multiple planets occupying a broad range of orbits, from close to wide, in a single planetary system.

  18. Discovering Habitable Earths, Hot Jupiters, and Other Close Planets with Microlensing

    NASA Astrophysics Data System (ADS)

    Di Stefano, R.

    2012-06-01

    Searches for planets via gravitational lensing have focused on cases in which the projected separation, a, between planet and star is comparable to the Einstein radius, RE . This paper considers smaller orbital separations and demonstrates that evidence of close-orbit planets can be found in the low-magnification portion of the light curves generated by the central star. We develop a protocol for discovering hot Jupiters as well as Neptune-mass and Earth-mass planets in the stellar habitable zone. When planets are not discovered, our method can be used to quantify the probability that the lens star does not have planets within specified ranges of the orbital separation and mass ratio. Nearby close-orbit planets discovered by lensing can be subject to follow-up observations to study the newly discovered planets or to discover other planets orbiting the same star. Careful study of the low-magnification portions of lensing light curves should produce, in addition to the discoveries of close-orbit planets, definite detections of wide-orbit planets through the discovery of "repeating" lensing events. We show that events exhibiting extremely high magnification can effectively be probed for planets in close, intermediate, and wide distance regimes simply by adding several-time-per-night monitoring in the low-magnification wings, possibly leading to gravitational lensing discoveries of multiple planets occupying a broad range of orbits, from close to wide, in a single planetary system.

  19. Export of newly formed LSW

    NASA Astrophysics Data System (ADS)

    Müller, Katharina; Klein, Birgit; Karstensen, Johannes; Fischer, Jürgen; Baumann, Till; Kanzow, Torsten

    2015-04-01

    The Atlantic meridional overturning circulation represents the strongest mechanism for oceanic northward heat transport. This is accomplished by moving warm water northward in the upper ocean compensated by a deep return flow of cold and dense North Atlantic Deep Water (NADW). Labrador Sea Water (LSW) constitutes the shallowest component of NADW. Since LSW is also supposed to be the most sensitive NADW component to climate change it is of particular interest. LSW is formed by deep convection not only in the centre of the Labrador Sea but also near its western boundary. Recent studies have suggested that LSW formed in the boundary region enters its export route from the Labrador Sea, the Deep Western Boundary Current, faster than LSW originating from the central Labrador Sea. In this study the spatial and temporal evolution of the export of newly formed LSW is investigated. For this purpose hydrographic mooring data from an array located at the western bounndary at 53°N starting in the late 1990s until 2014 and data from the Argo float network is used. The averaged seasonal salinity cycle at the array, particularly at the moorings further onshore, shows a pronounced freshwater signal in May indicating the arrival of newly formed LSW in the boundary current. In order to learn more about its preceding pathway and the corresponding export timescale the mooring data is complemented by data from Argo floats. Besides the annual cycles of LSW formation and export, their interannual variations are important aspects affecting the large-scale circulation. For instance, in years of relatively strong convection, as in 2008 and 2012, LSW is observed to pass the boundary current array at 53°N earlier, i.e. in February and March, respectively, than in years with weak convection, as in 2007 or 2010. Besides seasonal variations in the boundary current, a possible explanation for the earlier freshwater signal in years of enhanced convection might be a shift in convection sites

  20. Discovering phase transitions with unsupervised learning

    NASA Astrophysics Data System (ADS)

    Wang, Lei

    2016-11-01

    Unsupervised learning is a discipline of machine learning which aims at discovering patterns in large data sets or classifying the data into several categories without being trained explicitly. We show that unsupervised learning techniques can be readily used to identify phases and phases transitions of many-body systems. Starting with raw spin configurations of a prototypical Ising model, we use principal component analysis to extract relevant low-dimensional representations of the original data and use clustering analysis to identify distinct phases in the feature space. This approach successfully finds physical concepts such as the order parameter and structure factor to be indicators of a phase transition. We discuss the future prospects of discovering more complex phases and phase transitions using unsupervised learning techniques.

  1. Youngest Stellar Explosion in Our Galaxy Discovered

    NASA Astrophysics Data System (ADS)

    2008-05-01

    Astronomers have found the remains of the youngest supernova, or exploded star, in our Galaxy. The supernova remnant, hidden behind a thick veil of gas and dust, was revealed by the National Science Foundation's Very Large Array (VLA) and NASA's Chandra X-Ray Observatory, which could see through the murk. The object is the first example of a "missing population" of young supernova remnants. 1985 and 2008 VLA Images Move cursor over image to blink. VLA Images of G1.9+0.3 in 1985 and 2008: Circle for size comparison. CREDIT: Green, et al., NRAO/AUI/NSF From observing supernovae in other galaxies, astronomers have estimated that about three such stellar explosions should occur in our Milky Way every century. However, the most recent one known until now occurred around 1680, creating the remnant called Cassiopeia A. The newly-discovered object is the remnant of an explosion only about 140 years ago. "If the supernova rate estimates are correct, there should be the remnants of about 10 supernova explosions in the Milky Way that are younger than Cassiopeia A," said David Green of the University of Cambridge in the UK, who led the VLA study. "It's great to finally track one of them down." Supernova explosions, which mark the violent death of a star, release tremendous amounts of energy and spew heavy elements such as calcium and iron into interstellar space. They thus seed the clouds of gas and dust from which new stars and planets are formed and, through their blast shocks, can even trigger such formation. The lack of evidence for young supernova remnants in the Milky Way had caused astronomers to wonder if our Galaxy, which appears otherwise normal, differed in some unknown way from others. Alternatively, scientists thought that the "missing" Milky Way supernovae perhaps indicated that their understanding of the relationship between supernovae and other galactic processes was in error. The astronomers made their discovery by measuring the expansion of the debris from

  2. Plant Biofilm Inhibitors to Discover Biofilm Genes

    DTIC Science & Technology

    2011-04-08

    REPORT Final Report for Plant Biofilm Inhibitors to Discover Biofilm Genes 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: To control biofilms , we have...synthesized the natural biofilm inhibitor (5Z)-4-bromo-5-(bromomethylene) -3-butyl-2(5H)-furanone from the red alga Delisea pulchra and determined that...Research Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 15. SUBJECT TERMS biofilms , biofilm inhibitors Thomas K. Wood Texas Engineering

  3. MASTER: 2 OT discovered in Argentina

    NASA Astrophysics Data System (ADS)

    Shumkov, V.; Pogrosheva, T.; Lipunov, V.; Podesta, R.; Levato, H.; Gorbovskoy, E.; Tiurina, N.; Balanutsa, P.; Kuznetsov, A.; Vladimirov, V.; Gress, O.; Ivanov, K.; Chazov, V.; Lopez, C.; Podesta, F.; Saffe, C.

    2016-10-01

    MASTER-OAFA, located in Argentina, with auto-detection system (Lipunov et al., "MASTER Global Robotic Net", Advances in Astronomy, 2010, 30L) discovered OT source at (RA, Dec) = 03h 19m 42.92s -45d 30m 13.9s on 2016-10-27.27597 UT. The OT unfiltered magnitude is 16.9m (mlim=20.8m).

  4. [Fahr syndrome discovered following a bacterial meningitis].

    PubMed

    Sbai, H; Smail, L; Hamdani, S; Essatara, Y; Harrandou, M; Khatouf, M; Kanjaa, N

    2008-05-01

    Fahr's disease refers to a rare syndrome characterized by symmetrical and bilateral intracranial calcifications. The basal ganglia and dentate nucleus are the most common site of involvement and most cases present extrapyramidal symptoms. This disease is mostly associated with a phosphocalcic metabolism disorder, especially to hypoparathyroidism. The authors report a case of Fahr syndrome (FS) discovered when a young patient with hypocalcemia and bacterial meningitis had a cerebral CT scan disclosing intracerebral calcifications. She fully recovered after both meningitis and hypocalcemia were treated.

  5. What if Fleming had not discovered penicillin?

    PubMed Central

    Alharbi, Sulaiman Ali; Wainwright, Milton; Alahmadi, Tahani Awad; Salleeh, Hashim Bin; Faden, Asmaa A.; Chinnathambi, Arunachalam

    2014-01-01

    What would have happened had Alexander Fleming not discovered penicillin in 1928? Perhaps the obvious answer is that, someone else would have discovered penicillin during 1930s and the Oxford group, would still have purified it sometime in the early 1940s. Here, however, in this counterfactual account of the penicillin story, it is argued that without Fleming, penicillin might still be undiscovered and the antibiotic age would never have dawned. As a result, many of the recent developments in medicine, such as organ transplantation, might have been delayed or, at best, made more hazardous. Penicillin might have come onto the scene a few years later but, had Fleming overlooked the discovery, it seems certain that penicillin would not have saved countless Allied lives, during and after D-Day. Instead of having enjoyed fifty and more years of the antibiotic age, it is argued here, that we would have had to rely upon highly developed sulphonamides, so-called “supasulfas”, and other chemically-derived antibacterial drugs. Indeed, it might be the case that, even well into this new millennium, the antibiotic age has yet to dawn, and medicine is still waiting for someone to chance upon penicillin. Here we discuss what might have happened had Fleming not discovered penicillin and come to the conclusion that the medical armoury available today would have been far different and might have relied solely upon highly developed varieties of sulphonamides or similar, synthetic, non-antibiotic antibacterial agents. PMID:25183937

  6. Newly Installed S-1 Truss

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Launched October 7, 2002 aboard the Space Shuttle Orbiter Atlantis, the STS-112 mission lasted 11 days and performed three sessions of Extra Vehicular Activity (EVA). Its primary mission was to install the Starboard (S1) Integrated Truss Structure and Equipment Translation Aid (CETA) Cart to the International Space Station (ISS). The S1 truss provides structural support for the orbiting research facility's radiator panels, which use ammonia to cool the Station's complex power system. The S1 truss, attached to the S0 (S Zero) truss installed by the previous STS-110 mission, flows 637 pounds of anhydrous ammonia through three heat rejection radiators. The truss is 45-feet long, 15-feet wide, 10-feet tall, and weighs approximately 32,000 pounds. The CETA is the first of two human-powered carts that will ride along the International Space Station's railway providing a mobile work platform for future extravehicular activities by astronauts. This is a view of the newly installed S1 Truss as photographed during the mission's first scheduled EVA. The Station's Canadarm2 is in the foreground. Visible are astronauts Piers J. Sellers (lower left) and David A. Wolf (upper right), both STS-112 mission specialists.

  7. Newly Installed S-1 Truss

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Launched October 7, 2002 aboard the Space Shuttle Orbiter Atlantis, the STS-112 mission lasted 11 days and performed three sessions of Extra Vehicular Activity (EVA). Its primary mission was to install the Starboard (S1) Integrated Truss Structure and Equipment Translation Aid (CETA) Cart to the International Space Station (ISS). The S1 truss provides structural support for the orbiting research facility's radiator panels, which use ammonia to cool the Station's complex power system. The S1 truss, attached to the S0 (S Zero) truss installed by the previous STS-110 mission, flows 637 pounds of anhydrous ammonia through three heat rejection radiators. The truss is 45-feet long, 15-feet wide, 10-feet tall, and weighs approximately 32,000 pounds. The CETA is the first of two human-powered carts that will ride along the International Space Station's railway providing a mobile work platform for future extravehicular activities by astronauts. This is a view of the newly installed S1 Truss as photographed during the mission's first scheduled EVA. The Station's Canadarm2 is in the foreground. Visible are astronauts Piers J. Sellers (lower left) and David A. Wolf (upper right), both STS-112 mission specialists.

  8. Aerobic fitness of prepubescent children.

    PubMed

    Armstrong, N; Kirby, B J; McManus, A M; Welsman, J R

    1995-01-01

    This study was designed to enhance understanding of the assessment and interpretation of the aerobic fitness of prepubertal children. Written informed consent to participate was obtained from 70% of the children in year six of the 15 state schools in the city of Exeter. Twenty-five per cent of the eligible children in each school were randomly selected from those who volunteered. The data reported here are those obtained from the 111 boys (11.1 SD 0.4 years) and 53 girls (10.9 SD 0.3 years) classified as Tanner stage 1 in both pubic hair rating and either genitalia rating (boys) or breast rating (girls). Peak oxygen uptake (peak VO2) was determined using a discontinuous, incremental protocol on a treadmill. Only a minority of children demonstrated a levelling-off or plateau in VO2 despite an increase in exercise intensity. There was no evidence to suggest that the children who demonstrated a VO2 plateau had significantly (p < 0.05) higher peak VO2, peak heart rate, peak respiratory exchange ratio or peak blood lactate than those children who did not demonstrate a plateau in VO2. These findings indicate that a VO2 plateau should not be used as a requirement for defining a maximal exercise test with prepubertal children. Boys had a significantly (p < 0.01) higher peak VO2 than girls, whether expressed in 1.min-1 (1.78 vs 1.46) or in relation to body mass (51 vs 45 ml.kg-1.min-1). The results compare favourably with those of similarly aged children from other countries, but why prepubescent boys have significantly higher (13.3%) mass-related peak VO2 than prepubescent girls is not readily apparent. Although conventional, the expression of peak VO2 as per body mass ratio may not adequately partition out body-size differences. The influence of body mass was therefore removed using a linear adjustment scaling model and a log-linear model, but the boys' peak VO2 remained significantly (p < 0.01) higher than the girls' peak VO2 with the difference now being 16.0% and 16

  9. More Far-Side Deep Moonquake Nests Discovered

    NASA Technical Reports Server (NTRS)

    Nakamura, Y.; Jackson, John A.; Jackson, Katherine G.

    2004-01-01

    As reported last year, we started to reanalyze the seismic data acquired from 1969 to 1977 with a network of stations established on the Moon during the Apollo mission. The reason for the reanalysis was because recent advances in computer technology make it possible to employ much more sophisticated analysis techniques than was possible previously. The primary objective of the reanalysis was to search for deep moonquakes on the far side of the Moon and, if found, to use them to infer the structure of the Moon's deep interior, including a possible central core. The first step was to identify any new deep moonquakes that escaped our earlier search by applying a combination of waveform cross-correlation and single-link cluster analysis, and then to see if any of them are from previously unknown nests of deep moonquakes. We positively identified 7245 deep moonquakes, more than a five-fold increase from the previous 1360. We also found at least 88 previously unknown deep-moonquake nests. The question was whether any of these newly discovered nets were on the far side of the Moon, and we now report that our analysis of the data indicates that some of them are indeed on the far side.

  10. More Far-Side Deep Moonquake Nests Discovered

    NASA Technical Reports Server (NTRS)

    Nakamura, Y.; Jackson, John A.; Jackson, Katherine G.

    2004-01-01

    As reported last year, we started to reanalyze the seismic data acquired from 1969 to 1977 with a network of stations established on the Moon during the Apollo mission. The reason for the reanalysis was because recent advances in computer technology make it possible to employ much more sophisticated analysis techniques than was possible previously. The primary objective of the reanalysis was to search for deep moonquakes on the far side of the Moon and, if found, to use them to infer the structure of the Moon's deep interior, including a possible central core. The first step was to identify any new deep moonquakes that escaped our earlier search by applying a combination of waveform cross-correlation and single-link cluster analysis, and then to see if any of them are from previously unknown nests of deep moonquakes. We positively identified 7245 deep moonquakes, more than a five-fold increase from the previous 1360. We also found at least 88 previously unknown deep-moonquake nests. The question was whether any of these newly discovered nets were on the far side of the Moon, and we now report that our analysis of the data indicates that some of them are indeed on the far side.

  11. New Star Clusters Discovered in the GLIMPSE Survey

    NASA Astrophysics Data System (ADS)

    Mercer, E. P.; Clemens, D. P.; Meade, M. R.; Babler, B. L.; Indebetouw, R.; Whitney, B. A.; Watson, C.; Wolfire, M. G.; Wolff, M. J.; Bania, T. M.; Benjamin, R. A.; Cohen, M.; Dickey, J. M.; Jackson, J. M.; Kobulnicky, H. A.; Mathis, J. S.; Stauffer, J. R.; Stolovy, S. R.; Uzpen, B.; Churchwell, E. B.

    2005-12-01

    A systematic and automated search of the extensive GLIMPSE mid-infrared survey data of the inner Galaxy was carried out to uncover new star clusters. This search has yielded 59 new clusters. Using our automated search algorithm, these clusters were identified as significant localized overdensities in the GLIMPSE point-source catalog (GLMC) and archive (GLMA). Subsequent visual inspection of the GLIMPSE image mosaics confirmed the existence of these clusters plus an additional 33 heavily embedded clusters missed by our detection algorithm, for a total of 92 newly discovered clusters. These previously uncataloged clusters range in type from heavily embedded to fully exposed clusters. More than half of the clusters have memberships exceeding 35 stars, and nearly all the clusters have diameters of 3' or less. The Galactic latitude distribution of the clusters reveals that the majority are concentrated toward the Galactic midplane. There is an asymmetry in the number of clusters located above and below the midplane, with more clusters detected below the midplane. We also observe an asymmetry in the number of clusters detected in the northern and southern halves of the Galaxy, with more than twice as many clusters detected in the south.

  12. Drying and recovery of aerobic granules.

    PubMed

    Hu, Jianjun; Zhang, Quanguo; Chen, Yu-You; Lee, Duu-Jong

    2016-10-01

    To dehydrate aerobic granules to bone-dry form was proposed as a promising option for long-term storage of aerobic granules. This study cultivated aerobic granules with high proteins/polysaccharide ratio and then dried these granules using seven protocols: drying at 37°C, 60°C, 4°C, under sunlight, in dark, in a flowing air stream or in concentrated acetone solutions. All dried granules experienced volume shrinkage of over 80% without major structural breakdown. After three recovery batches, although with loss of part of the volatile suspended solids, all dried granules were restored most of their original size and organic matter degradation capabilities. The strains that can survive over the drying and storage periods were also identified. Once the granules were dried, they can be stored over long period of time, with minimal impact yielded by the applied drying protocols. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Newly Diagnosed Acute Promyelocytic Leukemia

    PubMed Central

    Avvisati, Giuseppe

    2011-01-01

    Acute promyelocytic leukemia (APL) represents a medical emergency with a high rate of early mortality. As a consequence, as soon as the diagnosis is suspected based upon cytologic criteria, it is necessary to start all- trans retinoic acid (ATRA) treatment without delay. For patients with newly diagnosed APL, induction therapy with ATRA plus anthracycline based chemotherapy is recommended. At present the combination of arsenic trioxide plus ATRA should be considered for patients who are not candidates for anthracycline-based therapy. For pediatric and adult patients with APL aged < 60 years who achieve a CR with induction, I recommend 3 intensive courses of consolidation chemotherapy associated to ATRA, targeted on the basis of the risk group at diagnosis. In patients treated with a very intensive consolidation chemotherapy maintenance treatment can be omitted. However If a maintenance treatment has to be adopted I suggest the use of intermittent ATRA for 15 days every 3 months for a period of 2 years, rather than ATRA associated to chemotherapy. Moreover, taking into account the medical literature, a reduced dosage of ATRA ( 25 mg/m2) in pediatric patients and a consolidation chemotherapy of reduced intensity in elderly patients is recommended. Furthermore, in order to maximize survival, careful attention should be reserved to the coagulopathy and to the appearance of the differentiation syndrome. Finally, PCR for the PML/RARA fusion gene on a bone marrow specimen every three months for two years, and then every six months for additional three years are needed during the follow-up. PMID:22220261

  14. Therapeutic aspects of aerobic dance participation.

    PubMed

    Estivill, M

    1995-01-01

    An ethnographic analysis of aerobic dance exercise culture was conducted to determine the impact of the culture on the mind-body connection. After a review of the predominant theories on the relationship between vigorous exercise and elevated mood, aerobic dance participants' experiences are reported to illustrate how cognitive experience and self-esteem may be influenced. Interviews revealed that some participants achieved a pleasantly altered state of consciousness and respite from depression and stress. The relationship of the work ethic to achievement of participant satisfaction is underscored.

  15. Permanent draft genome of strain ESFC-1: ecological genomics of a newly discovered lineage of filamentous diazotrophic cyanobacteria

    DOE PAGES

    Everroad, R. Craig; Stuart, Rhona K.; Bebout, Brad M.; ...

    2016-08-24

    The nonheterocystous filamentous cyanobacterium, strain ESFC-1, is a recently described member of the order Oscillatoriales within the Cyanobacteria. ESFC-1 has been shown to be a major diazotroph in the intertidal microbial mat system at Elkhorn Slough, CA, USA. Based on phylogenetic analyses of the 16S RNA gene, ESFC-1 appears to belong to a unique, genus-level divergence; the draft genome sequence of this strain has now been determined. Here we report features of this genome as they relate to the ecological functions and capabilities of strain ESFC-1. The 5,632,035 bp genome sequence encodes 4914 protein-coding genes and 92 RNA genes. Onemore » striking feature of this cyanobacterium is the apparent lack of either uptake or bi-directional hydrogenases typically expected within a diazotroph. In addition, a large genomic island is found that contains numerous low GC-content genes and genes related to extracellular polysaccharide production and cell wall synthesis and maintenance.« less

  16. Permanent draft genome of strain ESFC-1: ecological genomics of a newly discovered lineage of filamentous diazotrophic cyanobacteria

    SciTech Connect

    Everroad, R. Craig; Stuart, Rhona K.; Bebout, Brad M.; Detweiler, Angela M.; Lee, Jackson Z.; Woebken, Dagmar; Prufert-Bebout, Leslie; Pett-Ridge, Jennifer

    2016-08-24

    The nonheterocystous filamentous cyanobacterium, strain ESFC-1, is a recently described member of the order Oscillatoriales within the Cyanobacteria. ESFC-1 has been shown to be a major diazotroph in the intertidal microbial mat system at Elkhorn Slough, CA, USA. Based on phylogenetic analyses of the 16S RNA gene, ESFC-1 appears to belong to a unique, genus-level divergence; the draft genome sequence of this strain has now been determined. Here we report features of this genome as they relate to the ecological functions and capabilities of strain ESFC-1. The 5,632,035 bp genome sequence encodes 4914 protein-coding genes and 92 RNA genes. One striking feature of this cyanobacterium is the apparent lack of either uptake or bi-directional hydrogenases typically expected within a diazotroph. In addition, a large genomic island is found that contains numerous low GC-content genes and genes related to extracellular polysaccharide production and cell wall synthesis and maintenance.

  17. Where Is My Food? Brazilian Flower Fly Steals Prey from Carnivorous Sundews in a Newly Discovered Plant-Animal Interaction

    PubMed Central

    Rivadavia, Fernando; Gonella, Paulo M.; Pérez-Bañón, Celeste; Mengual, Ximo; Rojo, Santos

    2016-01-01

    A new interaction between insects and carnivorous plants is reported from Brazil. Larvae of the predatory flower fly Toxomerus basalis (Diptera: Syrphidae: Syrphinae) have been found scavenging on the sticky leaves of several carnivorous sundew species (Drosera, Droseraceae) in Minas Gerais and São Paulo states, SE Brazil. This syrphid apparently spends its whole larval stage feeding on prey trapped by Drosera leaves. The nature of this plant-animal relationship is discussed, as well as the Drosera species involved, and locations where T. basalis was observed. 180 years after the discovery of this flower fly species, its biology now has been revealed. This is (1) the first record of kleptoparasitism in the Syrphidae, (2) a new larval feeding mode for this family, and (3) the first report of a dipteran that shows a kleptoparasitic relationship with a carnivorous plant with adhesive flypaper traps. The first descriptions of the third instar larva and puparium of T. basalis based on Scanning Electron Microscope analysis are provided. PMID:27144980

  18. Degradation of 2,3-Diethyl-5-Methylpyrazine by a Newly Discovered Bacterium, Mycobacterium sp. Strain DM-11†

    PubMed Central

    Rappert, Sugima; Botsch, Kathrin Caroline; Nagorny, Stephanie; Francke, Wittko; Müller, Rudolf

    2006-01-01

    A bacterium was isolated from the waste gas treatment plant at a fishmeal processing company on the basis of its capacity to use 2,3-diethyl-5-methylpyrazine (DM) as a sole carbon and energy source. The strain, designated strain DM-11, grew optimally at 25°C and had a doubling time of 29.2 h. The strain did not grow on complex media like tryptic soy broth, Luria-Bertani broth, or nutrient broth or on simple carbon sources like glucose, acetate, oxoglutarate, succinate, or citrate. Only on Löwenstein-Jensen medium was growth observed. The 16S rRNA gene sequence of strain DM-11 showed the highest similarity (96.2%) to Mycobacterium poriferae strain ATCC 35087T. Therefore, strain DM-11 merits recognition as a novel species within the genus Mycobacterium. DM also served as a sole nitrogen source for the growth of strain DM-11. The degradation of DM by strain DM-11 requires molecular oxygen. The first intermediate was identified as 5,6-diethyl-2-hydroxy-3-methylpyrazine (DHM). Its disappearance was accompanied by the release of ammonium into the culture medium. No other metabolite was detected. We conclude that ring fission occurred directly after the formation of DHM and ammonium was eliminated after ring cleavage. Molecular oxygen was essential for the degradation of DHM. The expression of enzymes involved in the degradation of DM and DHM was regulated. Only cells induced by DM or DHM converted these compounds. Strain DM-11 also grew on 2-ethyl-5(6)-methylpyrazine (EMP) and 2,3,5-trimethylpyrazine (TMP) as a sole carbon, nitrogen, and energy source. In addition, the strain converted many pyrazines found in the waste gases of food industries cometabolically. PMID:16461697

  19. WASP-120 b, WASP-122 b, AND WASP-123 b: Three Newly Discovered Planets from the WASP-South Survey

    NASA Astrophysics Data System (ADS)

    Turner, O. D.; Anderson, D. R.; Collier Cameron, A.; Delrez, L.; Evans, D. F.; Gillon, M.; Hellier, C.; Jehin, E.; Lendl, M.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Ségransan, D.; Smalley, B.; Smith, A. M. S.; Triaud, A. H. M. J.; Udry, S.; West, R. G.

    2016-06-01

    We present the discovery by the WASP-South survey of three planets transiting moderately bright stars (V ≈ 11). WASP-120 b is a massive (4.85 M Jup) planet in a 3.6-day orbit that we find likely to be eccentric (e={0.059}-0.018+0.025) around an F5 star. WASP-122 b is a hot Jupiter (1.28 M Jup, 1.74 R Jup) in a 1.7-day orbit about a G4 star. Our predicted transit depth variation caused by the atmosphere of WASP-122 b suggests it is well suited to characterization. WASP-123 b is a hot Jupiter (0.90 M Jup, 1.32 R Jup) in a 3.0-day orbit around an old (∼7 Gyr) G5 star.

  20. Paleoseismology of a newly discovered scarp in the Yakima fold-and-thrust belt, Kittitas County, Washington

    USGS Publications Warehouse

    Barnett, Elizabeth A.; Sherrod, Brian L.; Norris, Robert; Gibbons, Douglas

    2013-01-01

    The Boylston Mountains anticlinal ridge is one of several that are cored by rocks of the Columbia River Basalt Group and, with the interceding synclinal valleys, constitute the Yakima fold-and-thrust belt of central Washington. Lidar data acquired from the U.S. Army's Yakima Training Center reveal a prominent, northwest-side-up, 65°- to 70°-trending, 3- to 4-meter-high scarp that cuts across the western end of the Boylston Mountains, perpendicular to the mapped anticline. The scarp continues to the northeast from the ridge on the southern side of Park Creek and across the low ridges for a total length of about 3 kilometers. A small stream deeply incises its flood plain where it projects across Johnson Canyon. The scarp is inferred to be late Quaternary in age based on its presence on the modern landscape and the incised flood-plain sediments in Johnson Canyon. Two trenches were excavated across this scarp. The most informative of the two, the Horned Lizard trench, exposed shallow, 15.5-Ma Grande Ronde Basalt, which is split by a deep, wide crack that is coincident with the base of the scarp and filled with wedges of silty gravels that are interpreted to represent at least two generations of fault colluvium that offset a buried soil.

  1. Adenophostins, newly discovered metabolites of Penicillium brevicompactum, act as potent agonists of the inositol 1,4,5-trisphosphate receptor.

    PubMed

    Takahashi, M; Tanzawa, K; Takahashi, S

    1994-01-07

    Potent inositol 1,4,5-trisphosphate (IP3) receptor agonists, adenophostin A and B, were found from fungal products. In spite of the striking structural difference from IP3, adenophostins were found to inhibit [3H]IP3 binding more potently than IP3: the Ki values for adenophostin A and B were both calculated to be 0.18 nM, while that of IP3 was 15 nM. Adenophostins induced Ca2+ release both from cerebellar microsomes and from intracellular Ca2+ stores in permeabilized NG108-15 cells. Adenophostins at concentration as low as 1 nM produced a significant Ca2+ release from cerebellar microsomes, and their activities were 100-fold more potent than IP3. In addition, heparin, an IP3 receptor antagonist, completely blocked the Ca2+ releasing activity of adenophostins. Adenophostins were resistant to phosphorylation and dephosphorylation by IP3-metabolizing enzymes, thereby providing a possible explanation for their prolonged activities. Adenophostin also bound to plasma membrane IP3 receptor with a high affinity and inhibited [3H]IP3 binding to jurkat human T-cell plasma membranes: the IC50 value for adenophostin A was 0.95 nM. Adenophostin may prove to be a powerful tool for investigating the physiological properties of IP3 and its receptor.

  2. Inhibition of the growth of Bacillus subtilis DSM10 by a newly discovered antibacterial protein from the soil metagenome

    PubMed Central

    O’Mahony, Mark M; Henneberger, Ruth; Selvin, Joseph; Kennedy, Jonathan; Doohan, Fiona; Marchesi, Julian R; Dobson, Alan D W

    2015-01-01

    A functional metagenomics based approach exploiting the microbiota of suppressive soils from an organic field site has succeeded in the identification of a clone with the ability to inhibit the growth of Bacillus subtilis DSM10. Sequencing of the fosmid identified a putative β-lactamase-like gene abgT. Transposon mutagenesis of the abgT gene resulted in a loss in ability to inhibit the growth of B. subtilis DSM10. Further analysis of the deduced amino acid sequence of AbgT revealed moderate homology to esterases, suggesting that the protein may possess hydrolytic activity. Weak lipolytic activity was detected; however the clone did not appear to produce any β-lactamase activity. Phylogenetic analysis revealed the protein is a member of the family VIII group of lipase/esterases and clusters with a number of proteins of metagenomic origin. The abgT gene was sub-cloned into a protein expression vector and when introduced into the abgT transposon mutant clones restored the ability of the clones to inhibit the growth of B. subtilis DSM10, clearly indicating that the abgT gene is involved in the antibacterial activity. While the precise role of this protein has yet to fully elucidated, it may be involved in the generation of free fatty acid with antibacterial properties. Thus functional metagenomic approaches continue to provide a significant resource for the discovery of novel functional proteins and it is clear that hydrolytic enzymes, such as AbgT, may be a potential source for the development of future antimicrobial therapies. PMID:25692994

  3. Inhibition of the growth of Bacillus subtilis DSM10 by a newly discovered antibacterial protein from the soil metagenome.

    PubMed

    O'Mahony, Mark M; Henneberger, Ruth; Selvin, Joseph; Kennedy, Jonathan; Doohan, Fiona; Marchesi, Julian R; Dobson, Alan D W

    2015-01-01

    A functional metagenomics based approach exploiting the microbiota of suppressive soils from an organic field site has succeeded in the identification of a clone with the ability to inhibit the growth of Bacillus subtilis DSM10. Sequencing of the fosmid identified a putative β-lactamase-like gene abgT. Transposon mutagenesis of the abgT gene resulted in a loss in ability to inhibit the growth of B. subtilis DSM10. Further analysis of the deduced amino acid sequence of AbgT revealed moderate homology to esterases, suggesting that the protein may possess hydrolytic activity. Weak lipolytic activity was detected; however the clone did not appear to produce any β-lactamase activity. Phylogenetic analysis revealed the protein is a member of the family VIII group of lipase/esterases and clusters with a number of proteins of metagenomic origin. The abgT gene was sub-cloned into a protein expression vector and when introduced into the abgT transposon mutant clones restored the ability of the clones to inhibit the growth of B. subtilis DSM10, clearly indicating that the abgT gene is involved in the antibacterial activity. While the precise role of this protein has yet to fully elucidated, it may be involved in the generation of free fatty acid with antibacterial properties. Thus functional metagenomic approaches continue to provide a significant resource for the discovery of novel functional proteins and it is clear that hydrolytic enzymes, such as AbgT, may be a potential source for the development of future antimicrobial therapies.

  4. A Newly-Discovered Mutation in the RFX6 Gene of the Rare Mitchell-Riley Syndrome

    PubMed Central

    Khan, Nusrat; Dandan, Waleed; Al Hassani, Noura; Hadi, Suha

    2016-01-01

    Mitchell-Riley syndrome is a genetic disorder characterized by neonatal diabetes, pancreatic hypoplasia, intestinal atresia and/or malrotation, biliary atresia, and gallbladder aplasia or hypoplasia. It was considered a variant of the Martinez-Frias syndrome with similar phenotypic characteristics, except for neonatal diabetes and tracheoesophageal fistula. However, the genetic mutation in (regulatory factor X on chromosome 6) RFX6 was only detected in babies who had diabetes, making it different from the previously known mutations for the disease. This is the first reported case of a classical Mitchell-Riley syndrome in the Arab peninsula along with additional features and novel mutations in the RFX6 gene. PMID:26761945

  5. The ac53, ac78, ac101, and ac103 Genes Are Newly Discovered Core Genes in the Family Baculoviridae

    PubMed Central

    Garavaglia, Matías Javier; Miele, Solange Ana Belén; Iserte, Javier Alonso; Belaich, Mariano Nicolás

    2012-01-01

    The family Baculoviridae is a large group of insect viruses containing circular double-stranded DNA genomes of 80 to 180 kbp, which have broad biotechnological applications. A key feature to understand and manipulate them is the recognition of orthology. However, the differences in gene contents and evolutionary distances among the known members of this family make it difficult to assign sequence orthology. In this study, the genome sequences of 58 baculoviruses were analyzed, with the aim to detect previously undescribed core genes because of their remote homology. A routine based on Multi PSI-Blast/tBlastN and Multi HaMStR allowed us to detect 31 of 33 accepted core genes and 4 orthologous sequences in the Baculoviridae which were not described previously. Our results show that the ac53, ac78, ac101 (p40), and ac103 (p48) genes have orthologs in all genomes and should be considered core genes. Accordingly, there are 37 orthologous genes in the family Baculoviridae. PMID:22933288

  6. Investigating a newly discovered firn aquifer on Disko Ice Cap, west Greenland: Insights from ground observations, remote sensing, and modeling

    NASA Astrophysics Data System (ADS)

    Trusel, L. D.; Das, S. B.; Smith, B.; Kuipers Munneke, P.; Evans, M. J.; Frey, K. E.; Osman, M.; York, A.

    2015-12-01

    Expanding and intensifying surface melt have accelerated contributions from Greenland to global sea level rise in recent decades. Yet, important questions remain regarding the evolution and eventual fate of this meltwater over time and space, a fact underscored by recent observations of expansive aquifers within the Greenland Ice Sheet firn. In April 2015 we observed liquid water retained at depth in an ice cap on Disko Island, central west Greenland. Two adjacent ~20 m firn/ice cores were collected before intercepting a layer saturated with liquid water as evident by water drainage from our cores. Borehole temperature profiling confirms increasing temperature with depth, revealing 0°C isothermal firn below ~10 m depth. Detailed physical stratigraphic analyses conducted on these cores allow us to assess firn properties and their small scale (< 1m) spatial heterogeneity. Notably, multiple, thick (>1 m) and likely impermeable refrozen melt horizons exist above the inferred aquifer surface, raising questions about processes of aquifer formation. To discern the spatial character of the observed firn liquid water and melt stratigraphy, we utilize ground penetrating radar collected in 2014, as well as airborne radar data collected through NASA Operation IceBridge in 2012 and 12 days prior to our field observations in 2015. Glaciochemical analyses on our ice cores reveal preservation of an annual signal allowing derivation of net snow accumulation rates. Combined with surface mass balance modeled by RACMO2.3 and melt assessed via microwave remote sensing, we investigate the recently prevailing climatic and glaciological conditions on Disko. This work will provide new insights into mechanisms of firn aquifer formation and sustenance more broadly, as well as the representation of aquifers in existing radar observations and firn models.

  7. New frontiers in water purification: highly stable amphopolycarboxyglycinate-stabilized Ag-AgCl nanocomposite and its newly discovered potential

    NASA Astrophysics Data System (ADS)

    Krutyakov, Yurii A.; Zherebin, Pavel M.; Kudrinskiy, Alexey A.; Zubavichus, Yan V.; Presniakov, Mikhail Yu; Yapryntsev, Alexey D.; Karabtseva, Anastasia V.; Mikhaylov, Dmitry M.; Lisichkin, Georgii V.

    2016-09-01

    A simple synthetic procedure for high-stable dispersions of porous composite Ag/AgCl nanoparticles stabilized with amphoteric surfactant sodium tallow amphopolycarboxyglycinate has been proposed for the first time. The prepared samples were characterized by UV-vis spectroscopy, x-ray powder diffraction (XRD), x-ray photoelectron spectroscopy, small area electron diffraction (SAED), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), and electron probe micro-analysis. In addition, measurements (carried out at the Kurchatov synchrotron radiation source stations) of the Ag K-edge extended x-ray absorption fine structure (EXAFS) and x-ray absorption near edge structure (XANES) spectra and XRD of the prepared nanoparticles have been performed. The obtained results suggest that small-sized Ag clusters are homogeneously distributed in the mass of the AgCl nanoparticle (~80 nm) formed during the synthesis. The Ag/AgCl dispersion demonstrates photocatalytic activity (with respect to methyl orange) and high bactericidal activity against E. coli. This activity is superior to the activity of both Ag and AgCl nanoparticles stabilized by the same surfactant. Thus, porous composite Ag/AgCl nanoparticles can be used as a multifunctional agent that is able to remove both pollutants and bacterium from water.

  8. Morphometric and molecular data on two mitochondrial genes of a newly discovered chimaeran fish ( Hydrolagus melanophasma, Chondrichthyes)

    NASA Astrophysics Data System (ADS)

    De La Cruz-Agüero, José; García-Rodríguez, Francisco Javier; Cota-Gómez, Víctor Manuel; Melo-Barrera, Felipe Neri; González-Armas, Rogelio

    2012-06-01

    Fresh and preserved (type material) specimens of the black ghost chimaera Hydrolagus melanophasma were compared for morphometric characteristics. A molecular comparison was also performed on two mitochondrial gene sequences (12S rRNA and 16S rRNA gene sequences). While significant differences in measurements were found, the differences were not attributable to sexual dimorphism or the quality of the specimens, but to the sample size and the type of statistical tests. The result of the genetic characterization showed that 12S rRNA and 16S rRNA genes represented robust molecular markers that characterized the species.

  9. Structure and petrology of newly discovered volcanic centers in the northern Kermadec-southern Tofua arc, South Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Graham, Ian J.; Reyes, Agnes G.; Wright, Ian C.; Peckett, Kimberley M.; Smith, Ian E. M.; Arculus, Richard J.

    2008-08-01

    The NZAPLUME III expedition of September-October 2004 to the northern Kermadec-southern Tofua (NKST) arc, between 28°52'S and 25°07'S, resulted in the discovery of at least seven new submarine volcanic centers and a substantial caldera complex adjacent to the previously known Monowai Seamount. The volcanic centers form a sublinear chain that coincides with the Kermadec Ridge crest in the south (Hinetapeka) and diverges ˜45 km westward of the ridge crest in the north ("V") just to the south of where the Louisville Ridge intersects with the arc. All of the centers contain calderas or caldera-like structures, as well as multiple cones, domes, fissure ridges, and vent fields. All show signs of recent eruptive and current hydrothermal activity. There are strong structural controls on edifice location, with cones and fissure ridges typically associated with faulting parallel to the regional ˜12° strike of the arc front. Several of the calderas are ellipsoidal, orientated northwest-southeast in the general direction of least compressive stress. Sampled volcanic rocks, representing the most recently erupted lavas, are all low-K tholeiites. Two of the centers, Gamble and Rakahore, yielded only high-silica dacite to rhyolite (69-74 wt% silica), whereas two others, Monowai and "V," yielded only basalt to andesite (48-63 wt% silica). Mineral assemblages are plagioclase-pyroxene dominated, with accessory Fe-Ti oxides, apatite, olivine, and quartz/tridymite/cristobalite, typical of dry volcanic arc systems. Hornblende occurs only in a felsitic rhyolite from Hinepuia volcanic center, and zircon is absent. Glass contents range to 57% in basalts-andesites (mean 20%), and 97% in andesites-rhyolites (mean 59%) and other quench textures, including swallow-tailed, plumose, or dendritic crystal forms and crystallites, are common. Most lavas are highly vesicular (≤63%; mean 28%) and have low volatile contents (mostly <2 wt%) which, together with the occurrence of tridymite or cristobalite, indicates explosive eruption and rapid cooling. Exceptions are rocks from "U" volcanic center, which have low vesicularity and low glass contents across a wide compositional range, indicating effusive eruption. Disequilibrium mineral textures, the frequent occurrence of xenoliths and xenocrysts, and macroscopic evidence for magma mingling indicate that many of the lavas are hybrids, having resided only a short time in upper crustal reservoirs prior to eruption. Silicic magmas are major components of NKST arc volcanism and caldera formation is the dominant eruptive style. The scale of silicic magmatism is in marked contrast to the dominant basaltic-andesitic magmatism in the southern Kermadec arc. With evidence from other arcs, silicic magmatism is now recognized as a major feature of intraoceanic arcs globally.

  10. L-Aspartate oxidase, a newly discovered enzyme of Escherichia coli, is the B protein of quinolinate synthetase.

    PubMed

    Nasu, S; Wicks, F D; Gholson, R K

    1982-01-25

    In Escherichia coli, quinolinic acid, a precursor of NAD+, is synthesized from L-aspartate and dihydroxyacetone phosphate. This synthesis requires two enzymes, a FAD-containing "B protein" and an "A protein." The B protein has been purified 500-fold from E. coli cells. The enzyme behaves as an L-aspartate oxidase. In the absence of A protein, it converts L-aspartate to oxaloacetate. To our knowledge, no enzyme with this activity has been described previously. The enzyme displays some unusual properties. In its role as B protein in quinolinic acid synthetase, product formation (quinolinic acid) is linear with protein concentration; however, when it functions as an L-aspartate oxidase, product formation (oxaloacetate) is a parabolic function of protein concentration. The L-aspartate oxidase activity also shows marked substrate activation at substrate concentrations above 1.0 mM. The L-aspartate oxidase and B protein activities of the enzyme are inhibited by NAD+, which is competitive with FAD. The immediate reaction product of the enzyme has the same characteristics (rate of decay to oxaloacetate, and condensation with dihydroxyacetone phosphate to form quinolinate) as the unstable reaction product (iminoaspartate) formed from D-aspartate oxidase. A reaction mechanism for the A protein-catalyzed condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinate is presented.

  11. [A newly-discovered deposit of sea-silt sulfide therapeutic muds in Primoskiĭ Kraĭ].

    PubMed

    Chelnokova, B I; Ivanov, E M; Shchetinin, V M

    2009-01-01

    A new rich deposit of sea-silt sulfide muds (Melkovodnenskoye) have recently been found on Island Russky, Primosky krai (territory). A comprehensive survey of bottom sediments in the Melkovodnaya (Voevoda) Bay was undertaken to map out the underwater landscape, calculate mud reserves, investigate physico-chemical, radiological, bacteriological, and microbial composition of the mud. Results of experimental and clinical studies give reason to recommend sea-silt sulfide muds of the Melkovodnenskoye deposit for therapeutic and preventive use not only by the sick but also by healthy subjects. In either group, they may exert beneficial effect by stimulating preventive and compensatory reactions of the organism, activating the immune system, preventing undesirable metabolic changes, and suppressing inflammatory processes.

  12. Newly discovered bio-control agents kill Sparganothis and cranberry fruitworm: Preliminary data on native nematode species

    USDA-ARS?s Scientific Manuscript database

    Historically, two of the most destructive insect pests in Wisconsin have been the Cranberry Fruitworm (CFW) and the Sparganothis Fruitworm (SFW). Once they’ve hatched, controlling them is a lot like “trench warfare,” where we throw various weapons at the enemy, but most of them miss. Many Wisconsin ...

  13. Direct biomolecule binding on nonfouling surfaces via newly discovered supramolecular self-assembly of lysozyme under physiological conditions.

    PubMed

    Yang, Peng

    2012-08-01

    When lysozyme is dissolved in a neutral HEPES buffer solution (pH = 7.4) with 0.001-0.050 M TCEP added, a fast phase transition process occurs and the resulting novel fiber-like hierarchical supramolecular assemblies made by primary spherical-particle aggregation can function as a "superglue" that binds strongly and quickly onto non-fouling coatings. This binding is highly selective towards lysozyme, and excludes synthetic, chemical/physical activation/deactivation (blocking) steps. By using biotinylated lysozyme, such a phase transition quickly creates a perfect biotinylated surface on non-fouling surfaces for avidin binding, showing great potential for the development of low-cost and practical biochips.

  14. San Juan sag: A newly discovered basin beneath San Juan volcanic field of south-central Colorado

    SciTech Connect

    Gries, R.R.

    1989-09-01

    The San Juan sag is a Laramide foreland basin formerly adjacent to and west of the Laramide northern Sangre de Cristo/San Luis highland. Wrench faulting (Eocene ) and rifting (Oligocene and Miocene) split this bounding uplift and formed the San Luis basin adjacent to and east of the sag. Volcanism concealed the San Juan sag with over 10,000 ft of intermediate volcanic deposits, and its presence remained in doubt until oil in the volcanic rocks encouraged exploration for the underlying sedimentary rocks. Drilling through the volcanic field since 1984 has revealed the presence of Paleocene and Eocene( ) clastic sediments, the Cretaceous Lewis, Mancos, and Dakota formations, and the Jurassic Morrison and Junction Creek formations. Additionally, oil and gas shows abound, and minor production has been established. Exploratory drilling and geophysical acquisitions have helped to define basin geometry, reservoir rocks, source rocks, and maturation and burial history.

  15. A newly discovered tRNA(1Asp) gene (aspV) of Escherichia coli K12.

    PubMed

    Horiuchi, T; Nagasawa, T; Takano, K; Sekiguchi, M

    1987-02-01

    We report a new tRNA(1Asp) gene near the dnaQ gene, which is located at 5 min on the Escherichia coli linkage map. We named it aspV. The sequence corresponding to the mature tRNA is identical with that of the two previously identified tRNA(1Asp) genes (aspT and aspU), but there is no homology in the sequences of their 3'- and 5'-flanking regions.

  16. Where Is My Food? Brazilian Flower Fly Steals Prey from Carnivorous Sundews in a Newly Discovered Plant-Animal Interaction.

    PubMed

    Fleischmann, Andreas; Rivadavia, Fernando; Gonella, Paulo M; Pérez-Bañón, Celeste; Mengual, Ximo; Rojo, Santos

    2016-01-01

    A new interaction between insects and carnivorous plants is reported from Brazil. Larvae of the predatory flower fly Toxomerus basalis (Diptera: Syrphidae: Syrphinae) have been found scavenging on the sticky leaves of several carnivorous sundew species (Drosera, Droseraceae) in Minas Gerais and São Paulo states, SE Brazil. This syrphid apparently spends its whole larval stage feeding on prey trapped by Drosera leaves. The nature of this plant-animal relationship is discussed, as well as the Drosera species involved, and locations where T. basalis was observed. 180 years after the discovery of this flower fly species, its biology now has been revealed. This is (1) the first record of kleptoparasitism in the Syrphidae, (2) a new larval feeding mode for this family, and (3) the first report of a dipteran that shows a kleptoparasitic relationship with a carnivorous plant with adhesive flypaper traps. The first descriptions of the third instar larva and puparium of T. basalis based on Scanning Electron Microscope analysis are provided.

  17. A newly discovered historical earthquake or merely a chronological mistake? Report of Mary Eliza Rogers from October 10, 1856

    NASA Astrophysics Data System (ADS)

    Zohar, Motti

    2017-09-01

    In her nineteenth century book "Domestic Life in Palestine", Mary Eliza Rogers describes the earthquake she had experienced in Haifa in the middle of the night between the 10th and 11th of October 1856. Although she reports that the earthquake was well felt in northern Palestine and even slightly damaged structures in Haifa, she is the only one who reported the event. However, on the following night, a destructive earthquake that occurred close to Crete was reported by many contemporary sources. Rogers' report is not cited in any of the existing earthquake catalogs or literature. Thus, the question arises is whether what she reports is an earthquake that was unknown to us till now or perhaps she merely dated incorrectly the event she had experienced. To resolve this question, I interpreted her description of the moon phase at the time of the earthquake occurrence and concluded that Rogers incorrectly dated the event whereas in fact what she had experienced was the Crete earthquake. The rest of her description is probably reliable and reinforces reports of damaged localities along the coast of northern Palestine and southern Lebanon.

  18. A Newly-Discovered Mutation in the RFX6 Gene of the Rare Mitchell-Riley Syndrome.

    PubMed

    Khan, Nusrat; Dandan, Waleed; Al Hassani, Noura; Hadi, Suha

    2016-06-05

    Mitchell-Riley syndrome is a genetic disorder characterized by neonatal diabetes, pancreatic hypoplasia, intestinal atresia and/or malrotation, biliary atresia, and gallbladder aplasia or hypoplasia. It was considered a variant of the Martinez-Frias syndrome with similar phenotypic characteristics, except for neonatal diabetes and tracheoesophageal fistula. However, the genetic mutation in (regulatory factor X on chromosome 6) RFX6 was only detected in babies who had diabetes, making it different from the previously known mutations for the disease. This is the first reported case of a classical Mitchell-Riley syndrome in the Arab peninsula along with additional features and novel mutations in the RFX6 gene.

  19. Roman vs. Arabic Computistics in Twelfth-Century England: A Newly Discovered Source (Collatio Compoti Romani et Arabici).

    PubMed

    Nothaft, C Philipp E

    2015-01-01

    A frequently overlooked aspect of the knowledge transfer from Arabic into Latin in the twelfth century is the introduction of the Islamo-Arabic calendar, which confronted Western computists with a radically different scheme of lunar reckoning that was in some ways superior to the 19-year lunar cycle of the Roman Church. One of the earliest sources to properly discuss this new system and compare it to the old one is the anonymous Collatio Compoti Romani et Arabici, found in a manuscript from Tewkesbury Abbey, Gloucestershire. This article contains the first edition and translation of this previously unknown text, preceded by an analysis of its content and sources. As will be argued, the text was written in the second quarter of the twelfth century as a reaction to the astronomical tables of al-Khwāizmī, recently translated by Adelard of Bath, as well as to eclipse observations that had exposed the flaws of the 'Roman' computation.

  20. Irisin, a newly discovered myokine, is a novel biomarker associated with physical activity in patients with chronic obstructive pulmonary disease.

    PubMed

    Ijiri, Naoki; Kanazawa, Hiroshi; Asai, Kazuhisa; Watanabe, Tetsuya; Hirata, Kazuto

    2015-05-01

    Irisin is a recently identified hormone secreted by skeletal myocytes, which has been proposed to mediate the beneficial effects of exercise. Physical activity has been emphasized as one of the principal targets of the treatment for chronic obstructive pulmonary disease (COPD). This study was designed to evaluate the possibility of using serum irisin level as a novel biomarker associated with physical activity in patients with COPD. We measured the serum irisin level in 72 COPD patients and 27 control subjects, and investigated its correlation to pulmonary function parameters, exercise capacity and physical activity level. In addition, we analysed the effects of acute and chronic exercise on serum irisin level. Fat-free mass index was not significantly different between the two study groups. However, lower serum irisin level was observed in COPD patients than in the control subjects (COPD patients: median (interquartile range) 31.6 (22.7-40.4) ng/mL; control subjects: 50.7 (39.3-65.8) ng/mL; P < 0.001). The serum irisin level did not significantly correlate with any pulmonary function parameters and 6-min walk distance. However, serum irisin level was associated with the physical activity level in all subjects. In COPD patients, acute exercise did not affect serum irisin level, but an 8-week exercise training was linked to the significant increase in its level. Circulating irisin could be used to evaluate physical activity in COPD patients and increased after an 8-week exercise training. Serum irisin level may prove to be a valuable biomarker in clinical follow up of COPD. © 2015 The Authors. Respirology published by Wiley Publishing Asia Pty Ltd on behalf of Asian Pacific Society of Respirology.

  1. Photometric properties for selected Algol-type binaries. VI. The newly discovered oEA star FR Orionis

    SciTech Connect

    Yang, Y.-G.; Wei, J.-Y.; Li, H.-L.

    2014-02-01

    New photometry of the neglected eclipsing binary FR Orionis was obtained in 2012 November and December. Using the updated Wilson-Devinney program, the photometric elements were deduced from two-color light curves. The results indicate that this system is a semi-detached binary, with a mass ratio of 0.325(± 0.002) and a fill-out factor of the primary of f{sub p} = 73.5(± 0.2)%. The oscillating light curves imply that FR Ori may be an oscillating EA (oEA)-type star with a rapidly pulsating, mass-accreting primary component. After we removed the theoretical light curves from the observations, Fourier analysis revealed that the more massive component possibly shows a δ Scuti type pulsation with four detected frequencies. The dominant frequency is f {sub 1} = 38.6c day{sup –1} (i.e., P {sub puls} = 37.3 minutes), and the pulsation constant is Q = 0.014 days. Based on all available eclipsing times, the orbital period is undergoing a secular period increase with a rate of dP/dt = +8.85(±0.66) × 10{sup –8} day yr {sup –1}, which may be interpreted by mass transfer from the secondary to the primary. We expect that the more massive component will fill its Roche lobe due to mass transfer of the secondary. Therefore, the oEA star FR Ori may evolve into a contact configuration.

  2. A newly discovered ubiquitin-conjugating enzyme E2 correlated with the cryogenic autolysis of Volvariella volvacea.

    PubMed

    Gong, Ming; Wang, Hong; Chen, Mingjie; Bao, Dapeng; Zhu, Qiuming; Tan, Qi

    2016-05-25

    In Volvariella volvacea, a species of edible mushroom, cryogenic autolysis is a typical part of abnormal metabolism. Previous functional annotation cluster analyses of cold-induced gene expression profiles have shown that the ubiquitin-conjugating enzyme E2 (UBE2), rather than the cyclin-like F-box domain alone, forms the functional cluster. In this study, analysis of gene expression profiling showed that only one type of UBE2 in V. volvacea (UBEV2) was significantly up-regulated. Further quantitative real-time PCR analysis confirmed that the expression of UBEV2 was significantly up-regulated (P<0.05) after cold-treatment lasting 4, 6, and 8h. This provided evidence that UBEV2 was closely correlated with cryogenic autolysis. The specific distribution of UBEV2 in recently diverged herb decay fungi indicated that UBEV2 was not evolutionarily correlated with early diverging fungi. Phylogenetic analysis indicated that UBEV2 was generated by horizontal gene transfer (HGT) from the ancestry of Selaginella moellendorffii UBE2. Further relative time estimation and detection of natural selection showed that there has been recent positive selection after HGT in UBEV2. Molecular modeling and logo analysis showed that the cysteine-cysteine motif is the characteristic of the UBEV2 family. These observations indicate that UBEV2 is a new type of UBE2 correlated with the cryogenic autolysis of V. volvacea. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. The diversity of ant-associated black yeasts: insights into a newly discovered world of symbiotic interactions.

    PubMed

    Voglmayr, Hermann; Mayer, Veronika; Maschwitz, Ulrich; Moog, Joachim; Djieto-Lordon, Champlain; Blatrix, Rumsaïs

    2011-10-01

    Based on pure culture studies and DNA phylogenetic analyses, black yeasts (Chaetothyriales, Ascomycota) are shown to be widely distributed and important components of numerous plant-ant-fungus networks, independently acquired by several ant lineages in the Old and New World. Data from ITS and LSU nu rDNA demonstrate that a high biodiversity of fungal species is involved. There are two common ant-fungus symbioses involving black yeasts: (1) on the carton walls of ant nests and galleries, and (2) the fungal mats growing within non-pathogenic naturally hollow structures (so-called domatia) provided by myrmecophytic plants as nesting space for ants (ant-plant symbiosis). Most carton- and domatia-inhabiting fungi stem from different phylogenetic lineages within Chaetothyriales, and almost all of the fungi isolated are still undescribed. Despite being closely related, carton and domatia fungi are shown to differ markedly in their morphology and ecology, indicating that they play different roles in these associations. The carton fungi appear to improve the stability of the carton, and several species are commonly observed to co-occur on the same carton. Carton fungi commonly have dark-walled monilioid hyphae, colouring the carton blackish and apparently preventing other fungi from invading the carton. Despite the simultaneous presence of usually several species of fungi, forming complex associations on the carton, little overlap is observed between carton fungi from different ant species, even those that co-occur in nature, indicating at least some host specificity of fungi. Most fungi present on carton belong to Chaetothyriales, but in a few samples, Capnodiales are also an important component. Carton fungi are difficult to assign to anamorph genera, as most lack conidiation. The domatia fungi are more specific. In domatia, usually only one or two fungal species co-occur, producing a dense layer on living host plant tissue in domatia. They have hyaline or light brown thin-walled hyphae, and are commonly sporulating. In both carton and domatia, the fungal species seem to be specific to each ant-plant symbiosis. Representative examples of carton and domatia ant-fungus symbioses are illustrated. We discuss hypotheses on the ecological significance of the Chaetothyriales associated with ants. Copyright © 2010 British Mycological Society. Published by Elsevier Ltd. All rights reserved.

  4. Permanent draft genome of strain ESFC-1: ecological genomics of a newly discovered lineage of filamentous diazotrophic cyanobacteria.

    PubMed

    Everroad, R Craig; Stuart, Rhona K; Bebout, Brad M; Detweiler, Angela M; Lee, Jackson Z; Woebken, Dagmar; Prufert-Bebout, Leslie; Pett-Ridge, Jennifer

    2016-01-01

    The nonheterocystous filamentous cyanobacterium, strain ESFC-1, is a recently described member of the order Oscillatoriales within the Cyanobacteria. ESFC-1 has been shown to be a major diazotroph in the intertidal microbial mat system at Elkhorn Slough, CA, USA. Based on phylogenetic analyses of the 16S RNA gene, ESFC-1 appears to belong to a unique, genus-level divergence; the draft genome sequence of this strain has now been determined. Here we report features of this genome as they relate to the ecological functions and capabilities of strain ESFC-1. The 5,632,035 bp genome sequence encodes 4914 protein-coding genes and 92 RNA genes. One striking feature of this cyanobacterium is the apparent lack of either uptake or bi-directional hydrogenases typically expected within a diazotroph. Additionally, a large genomic island is found that contains numerous low GC-content genes and genes related to extracellular polysaccharide production and cell wall synthesis and maintenance.

  5. A newly discovered fault in West Virginia and Virginia related to the location of the narrows of New River

    SciTech Connect

    Dennison, J.M. . Dept. of Geology)

    1994-03-01

    Stratigraphic measurements of the outcrop belt just northwest of the St. Clair fault near Lindside and on both sides of the New River valley reveal major omission of Upper Devonian and Lower Mississippian strata. About 1,000 feet of Brallier and Foreknobs Formations and up to 700 feet of Price (Pocono) formation are missing thee when compared with wells in flat-lying appalachian Plateau a few miles north of the proposed new fault, and when compared nearby along this Allegheny Front outcrop belt. The strata in the outcrop study area are in an overturned succession with dips generally 24--58[degree] and involving rocks from Huntersville chert at the St. Clair fault to Greenbrier Limestone on the southeast limb of the Glen Lyn syncline. The best exposure of the new fault is near Lindside, where it dips 79[degree]SE, and brings locally nearly flat, gently folded Brallier Formation in fault contact with the upper Price (Pocono) Formation only 9 stratigraphic feet beneath the Merrimac coal dipping 35[degree]SE overturned. This suggests a normal fault with about 2,600 feet dip-slip. If these age relationships are correct, the new fault is post-orogenic and may be relaxational. The effect of the new fault is to reduce the amount of resistant strata that New River had to cut through near the Narrows, and this is probably why New River crosses the 85 miles long trend of East River-Peters Mountain where it does. The new high-angle fault is also near the Giles County earthquake swarm.

  6. A newly discovered Bordetella species carries a transcriptionally active CRISPR-Cas with a small Cas9 endonuclease

    USDA-ARS?s Scientific Manuscript database

    The Cas9 endonuclease of the Type II-a clustered regularly interspersed short palindromic repeats (CRISPR), of Streptococcus pyogenes (SpCas9) has been adapted as a widely used tool for genome editing and genome engineering. Herein, we describe a gene encoding a novel Cas9 ortholog (BpsuCas9) and th...

  7. Brachyrhynchus membranaceus (Fabricius), an Old World flat bug (Hemiptera: Heteroptera: Aradidae) newly discovered in the Western Hemisphere

    USDA-ARS?s Scientific Manuscript database

    The Old World aradid Brachyrhynchus membranaceus (Fabricius), belonging to the subfamily Mezirinae, is reported for the first time from the Western Hemisphere. Since 2005, eight specimens have been intercepted at United States ports-of-entry in international commerce from Costa Rica, Dominican Repub...

  8. Newly discovered olfactory receptors in epidermal keratinocytes are associated with proliferation, migration, and re-epithelialization of keratinocytes.

    PubMed

    Denda, Mitsuhiro

    2014-11-01

    Skin contains receptors for various environmental factors. In this issue of the Journal, Busse et al. cloned a new olfactory receptor, OR2AT4, in keratinocytes. They show that the activation of OR2AT4 induces phosphorylation of extracellular signal-regulated kinases and p38 mitogen-activated protein kinases, and that it accelerates wound healing. OR2AT4 may be a promising candidate as a target in clinical drug development.

  9. American pikas (Ochotona princeps) in northwestern Nevada: A newly discovered population at a low-elevation site

    USGS Publications Warehouse

    Beever, E.A.; Wilkening, J.L.; McIvor, D.E.; Weber, S.S.; Brussard, P.F.

    2008-01-01

    The central tenet of island biogeography theory - that species assemblages on islands are functions of island area, isolation from mainlands, and vicariance - has been altered by the demonstrable effects that rapid climate change is imposing on insular faunas, at least in isolated mountaintops. Although populations of American pikas (Ochotona princeps) continue to suffer extirpations, and although the lower bounds of the pika's elevational distribution are shifting upslope across the Great Basin, we report here on the new discovery of a low-elevation population of pikas in a mountain range from which they had not been reported previously. This discovery, particularly in the context of relatively rapid ecological change, highlights the importance of seeking out original sources of information and performing spatially extensive fieldwork. Results presented here further illustrate that although thermal influences appear to be the single strongest determinant of pika distribution currently, such influences interact with a number of other factors to determine persistence.

  10. Discovering Functional Units in Continuous Speech

    PubMed Central

    Lim, Sung-Joo; Lacerda, Francisco; Holt, Lori L.

    2015-01-01

    Language learning requires that listeners discover acoustically variable functional units like phonetic categories and words from an unfamiliar, continuous acoustic stream. Although many category learning studies have examined how listeners learn to generalize across the acoustic variability inherent in the signals that convey the functional units of language, these studies have tended to focus upon category learning across isolated sound exemplars. However, continuous input presents many additional learning challenges that may impact category learning. Listeners may not know the timescale of the functional unit, its relative position in the continuous input, or its relationship to other evolving input regularities. Moving laboratory-based studies of isolated category exemplars toward more natural input is important to modeling language learning, but very little is known about how listeners discover categories embedded in continuous sound. In 3 experiments, adult participants heard acoustically variable sound category instances embedded in acoustically variable and unfamiliar sound streams within a video game task. This task was inherently rich in multisensory regularities with the to-be-learned categories and likely to engage procedural learning without requiring explicit categorization, segmentation, or even attention to the sounds. After 100 min of game play, participants categorized familiar sound streams in which target words were embedded and generalized this learning to novel streams as well as isolated instances of the target words. The findings demonstrate that even without a priori knowledge, listeners can discover input regularities that have the best predictive control over the environment for both non-native speech and nonspeech signals, emphasizing the generality of the learning. PMID:26010592

  11. Discovering Communicable Models from Earth Science Data

    NASA Technical Reports Server (NTRS)

    Schwabacher, Mark; Langley, Pat; Potter, Christopher; Klooster, Steven; Torregrosa, Alicia

    2002-01-01

    This chapter describes how we used regression rules to improve upon results previously published in the Earth science literature. In such a scientific application of machine learning, it is crucially important for the learned models to be understandable and communicable. We recount how we selected a learning algorithm to maximize communicability, and then describe two visualization techniques that we developed to aid in understanding the model by exploiting the spatial nature of the data. We also report how evaluating the learned models across time let us discover an error in the data.

  12. Planet Imager Discovers Young Kuiper Belt

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2015-07-01

    A debris disk just discovered around a nearby star is the closest thing yet seen to a young version of the Kuiper belt. This disk could be a key to better understanding the interactions between debris disks and planets, as well as how our solar system evolved early on in its lifetime. Hunting for an analog The best way to understand how the Kuiper belt — home to Pluto and thousands of other remnants of early icy planet formation in our solar system — developed would be to witness a similar debris disk in an earlier stage of its life. But before now, none of the disks we've discovered have been similar to our own: the rings are typically too large, the central star too massive, or the stars exist in regions very unlike what we think our Sun's birthplace was like. A collaboration led by Thayne Currie (National Astronomical Observatory of Japan) has changed this using the Gemini Planet Imager (GPI), part of a new generation of extreme adaptive-optics systems. The team discovered a debris disk of roughly the same size as the Kuiper belt orbiting the star HD 115600, located in the nearest OB association. The star is only slightly more massive than our Sun, and it lives in a star-forming region similar to the early Sun's environment. HD 115600 is different in one key way, however: it is only 15 million years old. This means that observing it gives us the perfect opportunity to observe how our solar system might have behaved when it was much younger. A promising future GPI's spatially-resolved spectroscopy, combined with measurements of the reflectivity of the disk, have led the team to suspect that the disk might be composed partly of water ice, just as the Kuiper belt is. The disk also shows evidence of having been sculpted by the motions of giant planets orbiting the central star, in much the same way as the outer planets of our solar system may have shaped the Kuiper belt. The observations of HD 115600 are some of the very first to emerge from GPI and the new

  13. Discovering the Universe, 6th edition

    NASA Astrophysics Data System (ADS)

    Comins, Neil F.; Kaufmann, William J.

    Discovering the Universe is the best-selling brief text for descriptive one-term astronomy courses (especially those with no mathematics prerequisites). Carried along by the book's vibrant main theme--the process of scientific discovery--readers will encounter spectacular sights, landmark experiments, and recent discoveries, while learning to avoid the pitfalls created by common misconceptions about astronomy. Now enhanced with a powerful technology and image projection package, this is the most exciting and effective edition yet. The accompanying CD-ROM features a special student version of the award-winning virtual planetarium software, Starry Night? Backyard.

  14. ANAEROBIC AND AEROBIC TREATMENT OF CHLORINATED ALIPHATIC COMPOUNDS

    EPA Science Inventory

    Biological degradation of 12 chlorinated aliphatic compounds (CACs) was assessed in bench-top reactors and in serum bottle tests. Three continuously mixed daily batch-fed reactor systems were evaluated: anaerobic, aerobic, and sequential-anaerobic-aerobic (sequential). Glucose,...

  15. ANAEROBIC AND AEROBIC TREATMENT OF CHLORINATED ALIPHATIC COMPOUNDS

    EPA Science Inventory

    Biological degradation of 12 chlorinated aliphatic compounds (CACs) was assessed in bench-top reactors and in serum bottle tests. Three continuously mixed daily batch-fed reactor systems were evaluated: anaerobic, aerobic, and sequential-anaerobic-aerobic (sequential). Glucose,...

  16. Aerobic Exercise: Top 10 Reasons to Get Physical

    MedlinePlus

    ... Regardless of age, weight or athletic ability, aerobic exercise is good for you. See why — then prepare ... longer and healthier. Need motivation? See how aerobic exercise affects your heart, lungs and blood flow. Then ...

  17. The Universe for all to discover

    NASA Astrophysics Data System (ADS)

    Ortiz-Gil, A.; Ballesteros, F.; Espinós, H.; Fernández-Soto, A.; Lanzara, M.; Moya, M. J.; Navarro, J.

    2015-05-01

    In the title of this paper, we have changed the slogan of the International Year of Astronomy, ``The Universe yours to discover" to ``The Universe for all to discover" in order to emphasize the need to think about broader audiences when we plan astronomical activities at school or during outreach events. The strategy we propose follows what is known as the Universal Design for Learning (UDL). UDL allows to reach to the general public as well as to audiences which might be regarded as ``special" because they have some disability. It has been shown that everybody has a preferred style of learning (some remember better what they see, others what they hear or what they touch) and therefore, everybody is more or less able under the different styles of learning. Through this talk I am going to outline some of the principles of the UDL that can be applied in the teaching and communication of Astronomy, along with an example of its implementation in the project ``A Touch of the Universe".

  18. Discovering Structural Regularity in 3D Geometry

    PubMed Central

    Pauly, Mark; Mitra, Niloy J.; Wallner, Johannes; Pottmann, Helmut; Guibas, Leonidas J.

    2010-01-01

    We introduce a computational framework for discovering regular or repeated geometric structures in 3D shapes. We describe and classify possible regular structures and present an effective algorithm for detecting such repeated geometric patterns in point- or mesh-based models. Our method assumes no prior knowledge of the geometry or spatial location of the individual elements that define the pattern. Structure discovery is made possible by a careful analysis of pairwise similarity transformations that reveals prominent lattice structures in a suitable model of transformation space. We introduce an optimization method for detecting such uniform grids specifically designed to deal with outliers and missing elements. This yields a robust algorithm that successfully discovers complex regular structures amidst clutter, noise, and missing geometry. The accuracy of the extracted generating transformations is further improved using a novel simultaneous registration method in the spatial domain. We demonstrate the effectiveness of our algorithm on a variety of examples and show applications to compression, model repair, and geometry synthesis. PMID:21170292

  19. Aerobic exercise in fibromyalgia: a practical review.

    PubMed

    Thomas, Eric N; Blotman, Francis

    2010-07-01

    The objective of the study was to determine the current evidence to support guidelines for aerobic exercise (AE) and fibromyalgia (FM) in practice, and to outline specific research needs in these areas. Data sources consisted of a PubMed search, 2007 Cochrane Data Base Systematic review, 2008 Ottawa panel evidence-based clinical practice guidelines, as well as additional references found from the initial search. Study selection included randomized clinical trials that compared an aerobic-only exercise intervention (land or pool based) with an untreated control, a non-exercise intervention or other exercise programs in patients responding to the 1990 American College of Rheumatology criteria for FM. The following outcome data were obtained: pain, tender points, perceived improvement in FM symptoms such as the Fibromyalgia Impact Questionnaire total score (FIQ), physical function, depression (e.g., Beck Depression Inventory, FIQ subscale for depression), fatigue and sleep were extracted from 19 clinical trials that considered the effects of aerobic-only exercise in FM patients. Data synthesis shows that there is moderate evidence of important benefit of aerobic-only exercise in FM on physical function and possibly on tender points and pain. It appears to be sufficient evidence to support the practice of AE as a part of the multidisciplinary management of FM. However, future studies must be more adequately sized, homogeneously assessed, and monitored for adherence, to draw definitive conclusions.

  20. Response of aerobic rice to Piriformospora indica.

    PubMed

    Das, Joy; Ramesh, K V; Maithri, U; Mutangana, D; Suresh, C K

    2014-03-01

    Rice cultivation under aerobic condition not only saves water but also opens up a splendid scope for effective application of beneficial root symbionts in rice crop unlike conventional puddled rice cultivation where water logged condition acts as constraint for easy proliferation of various beneficial soil microorganisms like arbuscular mycorrhizal (AM) fungi. Keeping these in view, an in silico investigation were carried out to explore the interaction of hydrogen phosphate with phosphate transporter protein (PTP) from P. indica. This was followed by greenhouse investigation to study the response of aerobic rice to Glomusfasciculatum, a conventional P biofertilizer and P. indica, an alternative to AM fungi. Computational studies using ClustalW tool revealed several conserved motifs between the phosphate transporters from Piriformospora indica and 8 other Glomus species. The 3D model of PTP from P. indica resembling "Mayan temple" was successfully docked onto hydrogen phosphate, indicating the affinity of this protein for inorganic phosphorus. Greenhouse studies revealed inoculation of aerobic rice either with P. indica, G. fasciculatum or both significantly enhanced the plant growth, biomass and yield with higher NPK, chlorophyll and sugar compared to uninoculated ones, P. indica inoculated plants being superior. A significantly enhanced activity of acid phosphatase and alkaline phosphatase were noticed in the rhizosphere soil of rice plants inoculated either with P. indica, G. fasciculatum or both, contributing to higher P uptake. Further, inoculation of aerobic rice plants with P. indica proved to be a better choice as a potential biofertilizer over mycorrhiza.

  1. Aerobic Exercise Prescription for Rheumatoid Arthritics.

    ERIC Educational Resources Information Center

    Evans, Blanche W.; Williams, Hilda L.

    The use of exercise as a general treatment for rheumatoid arthritics (RA) has included range of motion, muscular strength, water exercise and rest therapy while virtually ignoring possible benefits of aerobic exercise. The purposes of this project were to examine the guidelines for exercise prescription in relation to this special population and…

  2. Aerobic exercise training for adults with fibromyalgia.

    PubMed

    Bidonde, Julia; Busch, Angela J; Schachter, Candice L; Overend, Tom J; Kim, Soo Y; Góes, Suelen M; Boden, Catherine; Foulds, Heather Ja

    2017-06-21

    Exercise training is commonly recommended for individuals with fibromyalgia. This review is one of a series of reviews about exercise training for people with fibromyalgia that will replace the "Exercise for treating fibromyalgia syndrome" review first published in 2002. • To evaluate the benefits and harms of aerobic exercise training for adults with fibromyalgia• To assess the following specific comparisons ० Aerobic versus control conditions (eg, treatment as usual, wait list control, physical activity as usual) ० Aerobic versus aerobic interventions (eg, running vs brisk walking) ० Aerobic versus non-exercise interventions (eg, medications, education) We did not assess specific comparisons involving aerobic exercise versus other exercise interventions (eg, resistance exercise, aquatic exercise, flexibility exercise, mixed exercise). Other systematic reviews have examined or will examine these comparisons (Bidonde 2014; Busch 2013). We searched the Cochrane Library, MEDLINE, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Physiotherapy Evidence Database (PEDro), Thesis and Dissertation Abstracts, the Allied and Complementary Medicine Database (AMED), the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), and the ClinicalTrials.gov registry up to June 2016, unrestricted by language, and we reviewed the reference lists of retrieved trials to identify potentially relevant trials. We included randomized controlled trials (RCTs) in adults with a diagnosis of fibromyalgia that compared aerobic training interventions (dynamic physical activity that increases breathing and heart rate to submaximal levels for a prolonged period) versus no exercise or another intervention. Major outcomes were health-related quality of life (HRQL), pain intensity, stiffness, fatigue, physical function, withdrawals, and adverse events. Two review authors independently selected trials for inclusion, extracted

  3. Anaerobic and aerobic transformation of TNT

    SciTech Connect

    Kulpa, C.F.; Boopathy, R.; Manning, J.

    1996-12-31

    Most studies on the microbial metabolism of nitroaromatic compounds have used pure cultures of aerobic microorganisms. In many cases, attempts to degrade nitroaromatics under aerobic conditions by pure cultures result in no mineralization and only superficial modifications of the structure. However, mixed culture systems properly operated result in the transformation of 2,4,6-trinitrotoluene (TNT) and in some cases mineralization of TNT occurs. In this paper, the mixed culture system is described with emphasis on intermediates and the characteristics of the aerobic microbial process including the necessity for a co-substrate. The possibility of removing TNT under aerobic/anoxic conditions is described in detail. Another option for the biodegradation of TNT and nitroaromatics is under anaerobic, sulfate reducing conditions. In this instance, the nitroaromatic compounds undergo a series of reductions with the formation of amino compounds. TNT under sulfate reducing conditions is reduced to triaminotoluene presumably by the enzyme nitrite reductase, which is commonly found in many Desulfovibrio spp. The removal of nitro groups from TNT is achieved by a series of reductive reactions with the formation of ammonia and toluene by Desulfovibrio sp. (B strain). These metabolic processes could be applied to other nitroaromatic compounds like nitrobenzene, nitrobenzoic acids, nitrophenols, and aniline. The data supporting the anaerobic transformation of TNT under different growth condition are reviewed in this report.

  4. AEROBIC DENITRIFICATION: IMPLICATIONS FOR NITROGEN FATE MODELING

    EPA Science Inventory

    In the Mississippi, as well as most nitrogen-degraded rivers and streams, NO3- is the dominant N species and therefore understanding its biogeochemical behavior is critical for accurate nitrogen fate modeling. To our knowledge this is the first work to report aerobic denitrificat...

  5. Reflections on Psychotherapy and Aerobic Exercise.

    ERIC Educational Resources Information Center

    Silverman, Wade

    This document provides a series of reflections by a practicing psychologist on the uses of aerobic workouts in psychotherapy. Two case histories are cited to illustrate the contention that the mode of exercise, rather than simply its presence or absence, is the significant indicator of a patient's emotional well-being or psychopathology. The first…

  6. Reflections on Psychotherapy and Aerobic Exercise.

    ERIC Educational Resources Information Center

    Silverman, Wade

    This document provides a series of reflections by a practicing psychologist on the uses of aerobic workouts in psychotherapy. Two case histories are cited to illustrate the contention that the mode of exercise, rather than simply its presence or absence, is the significant indicator of a patient's emotional well-being or psychopathology. The first…

  7. AEROBIC DENITRIFICATION: IMPLICATIONS FOR NITROGEN FATE MODELING

    EPA Science Inventory

    In the Mississippi, as well as most nitrogen-degraded rivers and streams, NO3- is the dominant N species and therefore understanding its biogeochemical behavior is critical for accurate nitrogen fate modeling. To our knowledge this is the first work to report aerobic denitrificat...

  8. Media for the aerobic growth of campylobacter

    USDA-ARS?s Scientific Manuscript database

    The effect of agar and sodium bicarbonate (NaHCO3) concentration on aerobic growth of Campylobacter in a fumarate-pyruvate medium was examined. The broth medium was supplemented with 0.0 to 0.2% agar and inoculated with 106 CFU/ml of Campylobacter coli 33559, Campylobacter fetus 27349, Campylobacter...

  9. Aerobic biological treatment of thermophilically digested sludge.

    PubMed

    Kevbrina, M V; Nikolaev, Y A; Danilovich, D A; Vanyushina, A Ya

    2011-01-01

    Aerobic biological treatment of digested sludge was studied in a continuously operated laboratory set-up. An aerated reactor was filled with thermophilically digested sludge from the Moscow wastewater treatment plant and inoculated with special activated sludge. It was then operated at the chemostat mode at different flow rates. Processes of nitrification and denitrification, as well as dephosphatation, occurred simultaneously during biological aerobic treatment of thermophilically digested sludge. Under optimal conditions, organic matter degradation was 9.6%, the concentrations of ammonium nitrogen and phosphate decreased by 89 and 83%, respectively, while COD decreased by 12%. Dewaterability of digested sludge improved significantly. The processes were found to depend on hydraulic retention time, oxygen regime, and temperature. The optimal conditions were as follows: hydraulic retention time 3-4 days, temperature 30-35 degrees C, dissolved oxygen levels 0.2-0.5 mg/L at continuous aeration or 0.7-1 mg/L at intermittent aeration. Based on these findings, we propose a new combined technology of wastewater sludge treatment. The technology combines two stages: anaerobic digestion followed by aerobic biological treatment of digested sludge. The proposed technology makes it possible to degrade the sludge with conversion of approximately 45% volatile suspended solids to biogas, to improve nitrogen and phosphorus removal in reject water from sludge treatment units, and to achieve removal of malodorous substances after 8-9 days of anaerobic-aerobic sludge treatment.

  10. Adolescents' Interest and Performances in Aerobic Fitness Testing

    ERIC Educational Resources Information Center

    Zhu, Xihe; Chen, Senlin; Parrott, James

    2014-01-01

    This study examined adolescents' interest in aerobic fitness testing and its relation to the test performances. Adolescents (N = 356) from three middle schools participated in the study. The participants took two aerobic fitness tests: the Progressive Aerobic Cardiovascular Endurance Run (PACER) and One-Mile Run (1MR) with a two-day interval, and…

  11. Ventilation and Speech Characteristics during Submaximal Aerobic Exercise

    ERIC Educational Resources Information Center

    Baker, Susan E.; Hipp, Jenny; Alessio, Helaine

    2008-01-01

    Purpose: This study examined alterations in ventilation and speech characteristics as well as perceived dyspnea during submaximal aerobic exercise tasks. Method: Twelve healthy participants completed aerobic exercise-only and simultaneous speaking and aerobic exercise tasks at 50% and 75% of their maximum oxygen consumption (VO[subscript 2] max).…

  12. Adolescents' Interest and Performances in Aerobic Fitness Testing

    ERIC Educational Resources Information Center

    Zhu, Xihe; Chen, Senlin; Parrott, James

    2014-01-01

    This study examined adolescents' interest in aerobic fitness testing and its relation to the test performances. Adolescents (N = 356) from three middle schools participated in the study. The participants took two aerobic fitness tests: the Progressive Aerobic Cardiovascular Endurance Run (PACER) and One-Mile Run (1MR) with a two-day interval, and…

  13. Ventilation and Speech Characteristics during Submaximal Aerobic Exercise

    ERIC Educational Resources Information Center

    Baker, Susan E.; Hipp, Jenny; Alessio, Helaine

    2008-01-01

    Purpose: This study examined alterations in ventilation and speech characteristics as well as perceived dyspnea during submaximal aerobic exercise tasks. Method: Twelve healthy participants completed aerobic exercise-only and simultaneous speaking and aerobic exercise tasks at 50% and 75% of their maximum oxygen consumption (VO[subscript 2] max).…

  14. Discovering Self: Childbearing Adolescents' Maternal Identity.

    PubMed

    Macintosh, Janelle; Callister, Lynn Clark

    2015-01-01

    Adolescent pregnancy and motherhood have long been a topic of interest for many healthcare professionals. However, there are limited data on how childbearing adolescents incorporate motherhood identity into their sense of self. The purpose of this study was to explore how childbearing adolescents perceive motherhood as becoming part of their personal identity. This qualitative study using ethnographic data collection involved 7 months of observation, interaction, and interviews. Data were collected from nine expectant adolescents during in-depth interviews. All participants were patients at a teen mother and child clinic staffed by certified nurse midwives and a pediatrician. Narrative content analysis revealed the overall theme of discovering self, with three major themes: confirming the pregnancy, the loss of my body, and imagining my child in my arms. Adolescent mothers may need assistance to construct their maternal identity in order to strengthen self-perceptions and improve maternal/child outcomes.

  15. Discovering, Indexing and Interlinking Information Resources

    PubMed Central

    Celli, Fabrizio; Keizer, Johannes; Jaques, Yves; Konstantopoulos, Stasinos; Vudragović, Dušan

    2015-01-01

    The social media revolution is having a dramatic effect on the world of scientific publication. Scientists now publish their research interests, theories and outcomes across numerous channels, including personal blogs and other thematic web spaces where ideas, activities and partial results are discussed. Accordingly, information systems that facilitate access to scientific literature must learn to cope with this valuable and varied data, evolving to make this research easily discoverable and available to end users. In this paper we describe the incremental process of discovering web resources in the domain of agricultural science and technology. Making use of Linked Open Data methodologies, we interlink a wide array of custom-crawled resources with the AGRIS bibliographic database in order to enrich the user experience of the AGRIS website. We also discuss the SemaGrow Stack, a query federation and data integration infrastructure used to estimate the semantic distance between crawled web resources and AGRIS. PMID:26834982

  16. How to See a Recently Discovered Supernova

    SciTech Connect

    Nugent, Peter

    2011-01-01

    Berkeley Lab scientist Peter Nugent discusses a recently discovered supernova that is closer to Earth — approximately 21 million light-years away — than any other of its kind in a generation. Astronomers believe they caught the supernova within hours of its explosion, a rare feat made possible with a specialized survey telescope and state-of-the-art computational tools. The finding of such a supernova so early and so close has energized the astronomical community as they are scrambling to observe it with as many telescopes as possible, including the Hubble Space Telescope. More info on how to see it: http://newscenter.lbl.gov/feature-stories/2011/08/31/glimpse-cosmic-explosion/ News release: http://newscenter.lbl.gov/feature-stories/2011/08/25/supernova/

  17. Discovering Sentinel Rules for Business Intelligence

    NASA Astrophysics Data System (ADS)

    Middelfart, Morten; Pedersen, Torben Bach

    This paper proposes the concept of sentinel rules for multi-dimensional data that warns users when measure data concerning the external environment changes. For instance, a surge in negative blogging about a company could trigger a sentinel rule warning that revenue will decrease within two months, so a new course of action can be taken. Hereby, we expand the window of opportunity for organizations and facilitate successful navigation even though the world behaves chaotically. Since sentinel rules are at the schema level as opposed to the data level, and operate on data changes as opposed to absolute data values, we are able to discover strong and useful sentinel rules that would otherwise be hidden when using sequential pattern mining or correlation techniques. We present a method for sentinel rule discovery and an implementation of this method that scales linearly on large data volumes.

  18. How to See a Recently Discovered Supernova

    ScienceCinema

    Nugent, Peter

    2016-07-12

    Berkeley Lab scientist Peter Nugent discusses a recently discovered supernova that is closer to Earth — approximately 21 million light-years away — than any other of its kind in a generation. Astronomers believe they caught the supernova within hours of its explosion, a rare feat made possible with a specialized survey telescope and state-of-the-art computational tools. The finding of such a supernova so early and so close has energized the astronomical community as they are scrambling to observe it with as many telescopes as possible, including the Hubble Space Telescope. More info on how to see it: http://newscenter.lbl.gov/feature-stories/2011/08/31/glimpse-cosmic-explosion/ News release: http://newscenter.lbl.gov/feature-stories/2011/08/25/supernova/

  19. Discovering New Light States at Neutrino Experiments

    SciTech Connect

    Essig, Rouven; Harnik, Roni; Kaplan, Jared; Toro, Natalia; /Stanford U., Phys. Dept.

    2011-08-11

    Experiments designed to measure neutrino oscillations also provide major opportunities for discovering very weakly coupled states. In order to produce neutrinos, experiments such as LSND collide thousands of Coulombs of protons into fixed targets, while MINOS and MiniBooNE also focus and then dump beams of muons. The neutrino detectors beyond these beam dumps are therefore an excellent arena in which to look for long-lived pseudoscalars or for vector bosons that kinetically mix with the photon. We show that these experiments have significant sensitivity beyond previous beam dumps, and are able to partially close the gap between laboratory experiments and supernovae constraints on pseudoscalars. Future upgrades to the NuMI beamline and Project X will lead to even greater opportunities for discovery. We also discuss thin target experiments with muon beams, such as those available in COMPASS, and show that they constitute a powerful probe for leptophilic PNGBs.

  20. Discovering chemistry with an ab initio nanoreactor

    SciTech Connect

    Wang, Lee-Ping; Titov, Alexey; McGibbon, Robert; Liu, Fang; Pande, Vijay S.; Martínez, Todd J.

    2014-11-02

    Chemical understanding is driven by the experimental discovery of new compounds and reactivity, and is supported by theory and computation that provides detailed physical insight. While theoretical and computational studies have generally focused on specific processes or mechanistic hypotheses, recent methodological and computational advances harken the advent of their principal role in discovery. Here we report the development and application of the ab initio nanoreactor – a highly accelerated, first-principles molecular dynamics simulation of chemical reactions that discovers new molecules and mechanisms without preordained reaction coordinates or elementary steps. Using the nanoreactor we show new pathways for glycine synthesis from primitive compounds proposed to exist on the early Earth, providing new insight into the classic Urey-Miller experiment. Ultimately, these results highlight the emergence of theoretical and computational chemistry as a tool for discovery in addition to its traditional role of interpreting experimental findings.

  1. Discovering chemistry with an ab initio nanoreactor

    DOE PAGES

    Wang, Lee-Ping; Titov, Alexey; McGibbon, Robert; ...

    2014-11-02

    Chemical understanding is driven by the experimental discovery of new compounds and reactivity, and is supported by theory and computation that provides detailed physical insight. While theoretical and computational studies have generally focused on specific processes or mechanistic hypotheses, recent methodological and computational advances harken the advent of their principal role in discovery. Here we report the development and application of the ab initio nanoreactor – a highly accelerated, first-principles molecular dynamics simulation of chemical reactions that discovers new molecules and mechanisms without preordained reaction coordinates or elementary steps. Using the nanoreactor we show new pathways for glycine synthesis frommore » primitive compounds proposed to exist on the early Earth, providing new insight into the classic Urey-Miller experiment. Ultimately, these results highlight the emergence of theoretical and computational chemistry as a tool for discovery in addition to its traditional role of interpreting experimental findings.« less

  2. Discovering Rules by Meta-level Abduction

    NASA Astrophysics Data System (ADS)

    Inoue, Katsumi; Furukawa, Koichi; Kobayashi, Ikuo; Nabeshima, Hidetomo

    This paper addresses discovery of unknown relations from incomplete network data by abduction. Given a network information such as causal relations and metabolic pathways, we want to infer missing links and nodes in the network to account for observations. To this end, we introduce a framework of meta-level abduction, which performs abduction in the meta level. This is implemented in SOLAR, an automated deduction system for consequence finding, using a first-order representation for algebraic properties of causality and the full-clausal form of network information and constraints. Meta-level abduction by SOLAR is powerful enough to infer missing rules, missing facts, and unknown causes that involve predicate invention in the form of existentially quantified hypotheses. We also show an application of rule abduction to discover certain physical techniques and related integrity constraints within the subject area of Skill Science.

  3. Discovering New Drugs on the Cellular Level

    NASA Technical Reports Server (NTRS)

    2005-01-01

    With the Vision for Space Exploration calling for a sustained human presence in space, astronauts will need to grow plants, while in orbit, for nourishment that they will not receive from only consuming dehydrated foods. As a potential source of food for long-duration missions, space-grown plants could also give astronauts an important psychological boost, as fresh vegetables could serve as a welcomed change from monotonous meals consisting of reconstituted foods in plastic bags. Even more, these plants could likely aid in the recycling of air and wastewater on spacecraft. With a helping hand from a company by the name of Biolog, Inc., NASA is studying the impacts of decreased gravity and spaceborne bacteria on the plants being grown for food in space. With a helping hand from NASA, this very same company is creating powerful new cell- and bacteria-analysis tools for use in discovering and developing new drugs on Earth.

  4. Discovering chemistry with an ab initio nanoreactor

    NASA Astrophysics Data System (ADS)

    Martinez, Todd

    Traditional approaches for modeling chemical reaction networks such as those involved in combustion have focused on identifying individual reactions and using theoretical approaches to explore the underlying mechanisms. Recent advances involving graphical processing units (GPUs), commodity products developed for the videogaming industry, have made it possible to consider a distinct approach wherein one attempts to discover chemical reactions and mechanisms. We provide a brief summary of these developments and then discuss the concept behind the ``ab initio nanoreactor'' which explores the space of possible chemical reactions and molecular species for a given stoichiometry. The nanoreactor concept is exemplified with an example to the Urey-Miller reaction network which has been previously advanced as a potential model for prebiotic chemistry. We briefly discuss some of the future directions envisioned for the development of this nanoreactor concept.

  5. Discovering chemistry with an ab initio nanoreactor

    NASA Astrophysics Data System (ADS)

    Wang, Lee-Ping; Titov, Alexey; McGibbon, Robert; Liu, Fang; Pande, Vijay S.; Martínez, Todd J.

    2014-12-01

    Chemical understanding is driven by the experimental discovery of new compounds and reactivity, and is supported by theory and computation that provide detailed physical insight. Although theoretical and computational studies have generally focused on specific processes or mechanistic hypotheses, recent methodological and computational advances harken the advent of their principal role in discovery. Here we report the development and application of the ab initio nanoreactor—a highly accelerated first-principles molecular dynamics simulation of chemical reactions that discovers new molecules and mechanisms without preordained reaction coordinates or elementary steps. Using the nanoreactor, we show new pathways for glycine synthesis from primitive compounds proposed to exist on the early Earth, which provide new insight into the classic Urey-Miller experiment. These results highlight the emergence of theoretical and computational chemistry as a tool for discovery, in addition to its traditional role of interpreting experimental findings.

  6. Discovering chemistry with an ab initio nanoreactor.

    PubMed

    Wang, Lee-Ping; Titov, Alexey; McGibbon, Robert; Liu, Fang; Pande, Vijay S; Martínez, Todd J

    2014-12-01

    Chemical understanding is driven by the experimental discovery of new compounds and reactivity, and is supported by theory and computation that provide detailed physical insight. Although theoretical and computational studies have generally focused on specific processes or mechanistic hypotheses, recent methodological and computational advances harken the advent of their principal role in discovery. Here we report the development and application of the ab initio nanoreactor--a highly accelerated first-principles molecular dynamics simulation of chemical reactions that discovers new molecules and mechanisms without preordained reaction coordinates or elementary steps. Using the nanoreactor, we show new pathways for glycine synthesis from primitive compounds proposed to exist on the early Earth, which provide new insight into the classic Urey-Miller experiment. These results highlight the emergence of theoretical and computational chemistry as a tool for discovery, in addition to its traditional role of interpreting experimental findings.

  7. Discovering chemistry with an ab initio nanoreactor

    PubMed Central

    Wang, Lee-Ping; Titov, Alexey; McGibbon, Robert; Liu, Fang; Pande, Vijay S.; Martínez, Todd J.

    2014-01-01

    Chemical understanding is driven by the experimental discovery of new compounds and reactivity, and is supported by theory and computation that provides detailed physical insight. While theoretical and computational studies have generally focused on specific processes or mechanistic hypotheses, recent methodological and computational advances harken the advent of their principal role in discovery. Here we report the development and application of the ab initio nanoreactor – a highly accelerated, first-principles molecular dynamics simulation of chemical reactions that discovers new molecules and mechanisms without preordained reaction coordinates or elementary steps. Using the nanoreactor we show new pathways for glycine synthesis from primitive compounds proposed to exist on the early Earth, providing new insight into the classic Urey-Miller experiment. These results highlight the emergence of theoretical and computational chemistry as a tool for discovery in addition to its traditional role of interpreting experimental findings. PMID:25411881

  8. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.

    PubMed

    Ma, Xiaoyu; Li, Chenchen; Sun, Linchong; Huang, De; Li, Tingting; He, Xiaoping; Wu, Gongwei; Yang, Zheng; Zhong, Xiuying; Song, Libing; Gao, Ping; Zhang, Huafeng

    2014-10-10

    Aberrant expression of Lin28 and let-7 has been observed in many human malignancies. However, its functions and underlying mechanisms remain largely elusive. Here we show that aberrant expression of Lin28 and let-7 facilitates aerobic glycolysis, or Warburg effect, in cancer cells. Mechanistically, we discover that Lin28A and Lin28B enhance, whereas let-7 suppresses, aerobic glycolysis via targeting pyruvate dehydrogenase kinase 1, or PDK1, in a hypoxia- or hypoxia-inducible factor-1 (HIF-1)-independent manner, illustrating a novel pathway to mediate aerobic glycolysis of cancer cells even in ambient oxygen levels. Importantly, we further demonstrate that PDK1 is critical for Lin28A- and Lin28B-mediated cancer proliferation both in vitro and in vivo, establishing a previously unappreciated mechanism by which Lin28/let-7 axis facilitates Warburg effect to promote cancer progression. Our findings suggest a potential rationale to target PDK1 for cancer therapy in malignancies with aberrant expression of Lin28 and let-7.

  9. Distribution of Aerobic Bacteria Which Contain Bacteriochlorophyll a

    PubMed Central

    Shiba, Tsuneo; Simidu, Usio; Taga, Nobuo

    1979-01-01

    Sixteen strains of aerobic bacteria which contain bacteriochlorophyll a were isolated from the samples collected in aerobic marine environments: thalli of Enteromorpha linza, Porphyra sp., Sargussum horneri; beach sand; and the surface seawater from Aburatsubo Inlet. When they occurred, their proportions among the aerobic heterotrophic populations ranged from 0.9 to 1.1% in the seaweed samples and from 1.2 to 6.3% in the beach sand samples and were 0.9% in the seawater sample. The results suggested that the aerobic photopigmented bacteria widely inhabit aerobic marine environments. PMID:16345414

  10. 76 FR 4393 - Discover Financial Services Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Discover Financial Services Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION... Financial Services negotiated service agreement to the market dominant product list. This notice addresses... 3020, et seq., to add a Discover Financial Services (DFS) negotiated service agreement to the...

  11. A new population of protostars discovered by Herschel

    NASA Astrophysics Data System (ADS)

    Stutz, A. M.; Tobin, J.; Fischer, W.; S. T. Megeath; Stanke, T.; Ali, B.; Henning, T.

    2012-03-01

    We present a newly discovered Herschel--detected class of very red protostars found in the Herschel Orion Protostar Survey (HOPS). In contrast to the known Orion protostars targeted with HOPS, the new sources are undetected or very faint in the Spitzer 24 μm imaging. A subset of these sources is redder than any of the known Orion Class 0 protostars, and appear similar in their 70 μm to 24 μm colors to the most extreme Class 0 objects known. These new Orion protostars are likely to be in a very early and short lived stage of protostellar evolution. As a sample of extremely red sources at a common distance, they represent an important new population of protostars. The majority of these reddest sources exhibit associated IRAC 4.5, and 5.8 μm extended emission that suggests the presence of an outflow, confirming their protostellar nature. In addition, many of these sources are located within classical filaments as traced by Spitzer absorption features and APEX 870 μm dust emission maps. Fits of the broad--band SEDs to radiative transfer models of protostars suggest that the extremely red 70 μm to 24 μm colors result from a combination of nearly edge--on viewing angles and high envelope infall rates. We analyze the properties of the filaments from which these sources form using sub--mm and IRAM 30 m N_2H^+ measurements. Finally, we present the initial results of a search for outflows using IRAM 30 m CO maps. As a population of cold protostars detected by Herschel but not Spitzer, the PBRS extend the Spitzer--identified sample to earlier stages of envelope evolution, allowing the most complete census yet of the Orion protostellar population.

  12. Does Aerobic Exercise Influence Intrinsic Brain Activity? An Aerobic Exercise Intervention among Healthy Old Adults.

    PubMed

    Flodin, Pär; Jonasson, Lars S; Riklund, Katrin; Nyberg, Lars; Boraxbekk, C J

    2017-01-01

    Previous studies have indicated that aerobic exercise could reduce age related decline in cognition and brain functioning. Here we investigated the effects of aerobic exercise on intrinsic brain activity. Sixty sedentary healthy males and females (64-78 years) were randomized into either an aerobic exercise group or an active control group. Both groups recieved supervised training, 3 days a week for 6 months. Multimodal brain imaging data was acquired before and after the intervention, including 10 min of resting state brain functional magnetic resonance imaging (rs-fMRI) and arterial spin labeling (ASL). Additionally, a comprehensive battery of cognitive tasks assessing, e.g., executive function and episodic memory was administered. Both the aerobic and the control group improved in aerobic capacity (VO2-peak) over 6 months, but a significant group by time interaction confirmed that the aerobic group improved more. Contrary to our hypothesis, we did not observe any significant group by time interactions with regard to any measure of intrinsic activity. To further probe putative relationships between fitness and brain activity, we performed post hoc analyses disregarding group belongings. At baseline, VO2-peak was negativly related to BOLD-signal fluctuations (BOLDSTD) in mid temporal areas. Over 6 months, improvements in aerobic capacity were associated with decreased connectivity between left hippocampus and contralateral precentral gyrus, and positively to connectivity between right mid-temporal areas and frontal and parietal regions. Independent component analysis identified a VO2-related increase in coupling between the default mode network and left orbitofrontal cortex, as well as a decreased connectivity between the sensorimotor network and thalamus. Extensive exploratory data analyses of global efficiency, connectome wide multivariate pattern analysis (connectome-MVPA), as well as ASL, did not reveal any relationships between aerobic fitness and intrinsic

  13. Differences in the Aerobic Capacity of Flight Muscles between Butterfly Populations and Species with Dissimilar Flight Abilities

    PubMed Central

    Rauhamäki, Virve; Wolfram, Joy; Jokitalo, Eija; Hanski, Ilkka; Dahlhoff, Elizabeth P.

    2014-01-01

    Habitat loss and climate change are rapidly converting natural habitats and thereby increasing the significance of dispersal capacity for vulnerable species. Flight is necessary for dispersal in many insects, and differences in dispersal capacity may reflect dissimilarities in flight muscle aerobic capacity. In a large metapopulation of the Glanville fritillary butterfly in the Åland Islands in Finland, adults disperse frequently between small local populations. Individuals found in newly established populations have higher flight metabolic rates and field-measured dispersal distances than butterflies in old populations. To assess possible differences in flight muscle aerobic capacity among Glanville fritillary populations, enzyme activities and tissue concentrations of the mitochondrial protein Cytochrome-c Oxidase (CytOx) were measured and compared with four other species of Nymphalid butterflies. Flight muscle structure and mitochondrial density were also examined in the Glanville fritillary and a long-distance migrant, the red admiral. Glanville fritillaries from new populations had significantly higher aerobic capacities than individuals from old populations. Comparing the different species, strong-flying butterfly species had higher flight muscle CytOx content and enzymatic activity than short-distance fliers, and mitochondria were larger and more numerous in the flight muscle of the red admiral than the Glanville fritillary. These results suggest that superior dispersal capacity of butterflies in new populations of the Glanville fritillary is due in part to greater aerobic capacity, though this species has a low aerobic capacity in general when compared with known strong fliers. Low aerobic capacity may limit dispersal ability of the Glanville fritillary. PMID:24416122

  14. Differences in the aerobic capacity of flight muscles between butterfly populations and species with dissimilar flight abilities.

    PubMed

    Rauhamäki, Virve; Wolfram, Joy; Jokitalo, Eija; Hanski, Ilkka; Dahlhoff, Elizabeth P

    2014-01-01

    Habitat loss and climate change are rapidly converting natural habitats and thereby increasing the significance of dispersal capacity for vulnerable species. Flight is necessary for dispersal in many insects, and differences in dispersal capacity may reflect dissimilarities in flight muscle aerobic capacity. In a large metapopulation of the Glanville fritillary butterfly in the Åland Islands in Finland, adults disperse frequently between small local populations. Individuals found in newly established populations have higher flight metabolic rates and field-measured dispersal distances than butterflies in old populations. To assess possible differences in flight muscle aerobic capacity among Glanville fritillary populations, enzyme activities and tissue concentrations of the mitochondrial protein Cytochrome-c Oxidase (CytOx) were measured and compared with four other species of Nymphalid butterflies. Flight muscle structure and mitochondrial density were also examined in the Glanville fritillary and a long-distance migrant, the red admiral. Glanville fritillaries from new populations had significantly higher aerobic capacities than individuals from old populations. Comparing the different species, strong-flying butterfly species had higher flight muscle CytOx content and enzymatic activity than short-distance fliers, and mitochondria were larger and more numerous in the flight muscle of the red admiral than the Glanville fritillary. These results suggest that superior dispersal capacity of butterflies in new populations of the Glanville fritillary is due in part to greater aerobic capacity, though this species has a low aerobic capacity in general when compared with known strong fliers. Low aerobic capacity may limit dispersal ability of the Glanville fritillary.

  15. Fatiguing upper body aerobic exercise impairs balance.

    PubMed

    Douris, Peter C; Handrakis, John P; Gendy, Joseph; Salama, Mina; Kwon, Dae; Brooks, Richard; Salama, Nardine; Southard, Veronica

    2011-12-01

    Douris, PC, Handrakis, JP, Gendy, J, Salama, M, Kwon, D, Brooks, R, Salama, N, and Southard, V. Fatiguing upper body aerobic exercise impairs balance. J Strength Cond Res 25(12): 3299-3305, 2011-There are many studies that have examined the effects of selectively fatiguing lower extremity muscle groups with various protocols, and they have all shown to impair balance. There is limited research regarding the effect of fatiguing upper extremity exercise on balance. Muscle fiber-type recruitment patterns may be responsible for the difference between balance impairments because of fatiguing aerobic and anaerobic exercise. The purpose of our study was to investigate the effect that aerobic vs. anaerobic fatigue, upper vs. lower body fatigue will have on balance, and if so, which combination will affect balance to a greater degree. Fourteen healthy subjects, 7 men and 7 women (mean age 23.5 ± 1.7 years) took part in this study. Their mean body mass index was 23.6 ± 3.2. The study used a repeated-measures design. The effect on balance was documented after the 4 fatiguing conditions: aerobic lower body (ALB), aerobic upper body (AUB), anaerobic lower body, anaerobic upper body (WUB). The aerobic conditions used an incremental protocol performed to fatigue, and the anaerobic used the Wingate protocol. Balance was measured as a single-leg stance stability score using the Biodex Balance System. A stability score for each subject was recorded immediately after each of the 4 conditions. A repeated-measures analysis of variance with the pretest score as a covariate was used to analyze the effects of the 4 fatiguing conditions on balance. There were significant differences between the 4 conditions (p = 0.001). Post hoc analysis revealed that there were significant differences between the AUB, mean score 4.98 ± 1.83, and the WUB, mean score 4.09 ± 1.42 (p = 0.014) and between AUB and ALB mean scores 4.33 ± 1.40 (p = 0.029). Normative data for single-leg stability testing for

  16. Facilitating aerobic exercise training in older adults with Alzheimer's disease.

    PubMed

    Yu, Fang; Kolanowski, Ann

    2009-01-01

    Emerging science suggests that aerobic exercise might modify the pathophysiology of Alzheimer's disease (AD) and improve cognition. However, there are no clinical practice guidelines for aerobic exercise prescription and training in older adults with AD. A few existing studies showed that older adults with AD can participate in aerobic exercise and improve dementia symptoms, but lack adequate descriptions of their aerobic exercise training programs and their clinical applicability. In this paper, we summarize current knowledge about the potential benefits of aerobic exercise in older adults with AD. We then describe the development of a moderate-intensity aerobic exercise program for this population and report results from its initial testing in a feasibility trial completed by two persons with AD. Two older adults with AD completed the aerobic exercise program. Barriers to the program's implementation are described, and methods to improve more wide-spread adoption of such programs and the design of future studies that test them are suggested.

  17. DISCOVER in Middle School: Identifying Gifted Minority Students.

    ERIC Educational Resources Information Center

    Sarouphim, Ketty M.

    This study investigated the effectiveness of a performance-based assessment (DISCOVER (Discovering Intellectual Strengths and Capabilities through Observation while allowing for Varied Ethnic Responses)) in identifying gifted minority middle school students. Research questions focused on examining the alignment between DISCOVER and Gardner's…

  18. Discovering the Ancient Maya from Space

    NASA Technical Reports Server (NTRS)

    Sever, T. L.

    2008-01-01

    The Pet6n region of northern Guatemala contains some of the most significant Mayan archeological sites in Latin America. It was in this region that the Maya civilization began, flourished, and abruptly disappeared. Remote sensing technology is helping to locate and map ancient Maya sites that are threatened today by accelerating deforestation and looting. Thematic Mapper, IKONOS, and QuickBird satellite, and airborne STAR-3i and AIRSAR radar data, combined with Global Positioning System (GPS) technology, are successfully detecting ancient Maya features such as sites, roadways, canals, and water reservoirs. Satellite imagery is also being used to map the bajos, which are seasonally flooded swamps that cover over 40% of the land surface. Through the use of various airborne and satellite sensor systems we have been able to detect and map ancient causeways, temples, reservoirs, and land forms, and locate these features on the ground through GPS technology. Recently, we have discovered that there is a strong relationship between a tropical forest vegetation signature in satellite imagery and the location of archeological sites. We believe that the use of limestone and lime plasters in ancient Maya construction affects the moisture, nutrition, and plant species of the surface vegetation. We have mapped these vegetation signatures in the imagery and verified through field survey that they are indicative of archeological sites. Through the use of remote sensing and GIS technology it is possible to identify unrecorded archeological features in a dense tropical forest environment and monitor these cultural features for their protection.

  19. Discovering the Ancient Maya From Space

    NASA Technical Reports Server (NTRS)

    Sever, T. L.

    2007-01-01

    The Peten region of northern Guatemala contains some of the most significant Mayan archeological sites in Latin America. It was in this region that the Maya civilization began, flourished, and abruptly disappeared. Remote sensing technology is helping to locate and map ancient Maya sites that are threatened today by accelerating deforestation and looting. Thematic Mapper, IKONOS, and QuickBird satellite, and airborne STAR-3i and AIRSAR radar data, combined with Global Positioning System (GPS) technology, are successfully detecting ancient Maya features such as sites, roadways, canals, and water reservoirs. Satellite imagery is also being used to map the bajos, which are seasonally flooded swamps that cover over 40% of the land surface. Through the use of various airborne and satellite sensor systems we have been able to detect and map ancient causeways, temples, reservoirs, and land forms, and locate these features on the ground through GPS technology. Recently, we have discovered that there is a strong relationship between a tropical forest vegetation signature in satellite imagery and the location of archeological sites. We believe that the use o f limestone and lime plasters in ancient Maya construction affects the moisture, nutrition, and plant species of the surface vegetation. We have mapped these vegetation signatures in the imagery and verified through field survey that they are indicative of archeological sites. Through the use of remote sensing and GIS technology it is possible to identify unrecorded archeological features in a dense tropical forest environment and monitor these cultural features for their protection.

  20. Has the Higgs boson been discovered?

    PubMed

    Renton, Peter

    2004-03-11

    The standard model of particle physics describes the strong and electroweak interactions of fermions (spin-1/2), gauge bosons (spin-1) and a final vital ingredient--the spin-0 Higgs boson, which gives masses to the other particles. But the Higgs boson has yet to be discovered, and its own mass is not specified by the theory. There is some evidence (although statistically not very significant) for its detection at a mass of about 115 GeV/c2, from electron-positron interactions at LEP (the Large Electron Positron collider). Indirect methods can also be used to constrain the mass of the Higgs boson, because it affects other observable quantities (for example, the mass of the W boson and some measurable properties of the Z boson). An indirect determination of the Higgs boson mass from the most recent measurements of such quantities yields a value compatible with 115 GeV/c2, but with some important caveats arising from inconsistencies in the present data.

  1. Discover Space: an IYA program for libraries

    NASA Astrophysics Data System (ADS)

    Dusenbery, P.

    2009-12-01

    Across the country, there is a growing concern regarding the number of students entering science and technology careers. While the focus for education reform is on school improvement, there is considerable research that supports the role that out-of-school experiences can play in student achievement. This is particularly true when family interactions are factored in. Libraries provide an untapped resource for engaging underserved youth and their families in fostering an appreciation and deeper understanding of science and technology topics. The nation’s more than 17,000 public libraries attract diverse audiences in almost every community. Science exhibits in libraries could potentially reach many adults and upper elementary and middle school students with STEM content. The Space Science Institute (SSI) is partnering with the American Library Association (ALA) to develop a pilot exhibit called Discover Space. The exhibit includes two areas: Space Storms and Star Quest and is currently on tour in Colorado. It is a featured IYA outreach project from SSI. This presentation will focus on the results of a national survey of libraries that SSI and ALA conducted in 2008 about interest in STEM exhibits as well as the development process that was used to design and fabricate the exhibit. Preliminary evaluation results will also be shared. The presentation will conclude with an examination of how this program could benefit underserved communities around the country.

  2. Discovering relations between indirectly connected biomedical concepts.

    PubMed

    Weissenborn, Dirk; Schroeder, Michael; Tsatsaronis, George

    2015-01-01

    The complexity and scale of the knowledge in the biomedical domain has motivated research work towards mining heterogeneous data from both structured and unstructured knowledge bases. Towards this direction, it is necessary to combine facts in order to formulate hypotheses or draw conclusions about the domain concepts. This work addresses this problem by using indirect knowledge connecting two concepts in a knowledge graph to discover hidden relations between them. The graph represents concepts as vertices and relations as edges, stemming from structured (ontologies) and unstructured (textual) data. In this graph, path patterns, i.e. sequences of relations, are mined using distant supervision that potentially characterize a biomedical relation. It is possible to identify characteristic path patterns of biomedical relations from this representation using machine learning. For experimental evaluation two frequent biomedical relations, namely "has target", and "may treat", are chosen. Results suggest that relation discovery using indirect knowledge is possible, with an AUC that can reach up to 0.8, a result which is a great improvement compared to the random classification, and which shows that good predictions can be prioritized by following the suggested approach. Analysis of the results indicates that the models can successfully learn expressive path patterns for the examined relations. Furthermore, this work demonstrates that the constructed graph allows for the easy integration of heterogeneous information and discovery of indirect connections between biomedical concepts.

  3. Discovering the Ancient Maya From Space

    NASA Technical Reports Server (NTRS)

    Sever, T. L.

    2007-01-01

    The Peten region of northern Guatemala contains some of the most significant Mayan archeological sites in Latin America. It was in this region that the Maya civilization began, flourished, and abruptly disappeared. Remote sensing technology is helping to locate and map ancient Maya sites that are threatened today by accelerating deforestation and looting. Thematic Mapper, IKONOS, and QuickBird satellite, and airborne STAR-3i and AIRSAR radar data, combined with Global Positioning System (GPS) technology, are successfully detecting ancient Maya features such as sites, roadways, canals, and water reservoirs. Satellite imagery is also being used to map the bajos, which are seasonally flooded swamps that cover over 40% of the land surface. Through the use of various airborne and satellite sensor systems we have been able to detect and map ancient causeways, temples, reservoirs, and land forms, and locate these features on the ground through GPS technology. Recently, we have discovered that there is a strong relationship between a tropical forest vegetation signature in satellite imagery and the location of archeological sites. We believe that the use o f limestone and lime plasters in ancient Maya construction affects the moisture, nutrition, and plant species of the surface vegetation. We have mapped these vegetation signatures in the imagery and verified through field survey that they are indicative of archeological sites. Through the use of remote sensing and GIS technology it is possible to identify unrecorded archeological features in a dense tropical forest environment and monitor these cultural features for their protection.

  4. Discovering the Ancient Maya from Space

    NASA Technical Reports Server (NTRS)

    Sever, T. L.

    2008-01-01

    The Pet6n region of northern Guatemala contains some of the most significant Mayan archeological sites in Latin America. It was in this region that the Maya civilization began, flourished, and abruptly disappeared. Remote sensing technology is helping to locate and map ancient Maya sites that are threatened today by accelerating deforestation and looting. Thematic Mapper, IKONOS, and QuickBird satellite, and airborne STAR-3i and AIRSAR radar data, combined with Global Positioning System (GPS) technology, are successfully detecting ancient Maya features such as sites, roadways, canals, and water reservoirs. Satellite imagery is also being used to map the bajos, which are seasonally flooded swamps that cover over 40% of the land surface. Through the use of various airborne and satellite sensor systems we have been able to detect and map ancient causeways, temples, reservoirs, and land forms, and locate these features on the ground through GPS technology. Recently, we have discovered that there is a strong relationship between a tropical forest vegetation signature in satellite imagery and the location of archeological sites. We believe that the use of limestone and lime plasters in ancient Maya construction affects the moisture, nutrition, and plant species of the surface vegetation. We have mapped these vegetation signatures in the imagery and verified through field survey that they are indicative of archeological sites. Through the use of remote sensing and GIS technology it is possible to identify unrecorded archeological features in a dense tropical forest environment and monitor these cultural features for their protection.

  5. Discovering the structure of mathematical problem solving.

    PubMed

    Anderson, John R; Lee, Hee Seung; Fincham, Jon M

    2014-08-15

    The goal of this research is to discover the stages of mathematical problem solving, the factors that influence the duration of these stages, and how these stages are related to the learning of a new mathematical competence. Using a combination of multivariate pattern analysis (MVPA) and hidden Markov models (HMM), we found that participants went through 5 major phases in solving a class of problems: A Define Phase where they identified the problem to be solved, an Encode Phase where they encoded the needed information, a Compute Phase where they performed the necessary arithmetic calculations, a Transform Phase where they performed any mathematical transformations, and a Respond Phase where they entered an answer. The Define Phase is characterized by activity in visual attention and default network regions, the Encode Phase by activity in visual regions, the Compute Phase by activity in regions active in mathematical tasks, the Transform Phase by activity in mathematical and response regions, and the Respond phase by activity in motor regions. The duration of the Compute and Transform Phases were the only ones that varied with condition. Two features distinguished the mastery trials on which participants came to understand a new problem type. First, the duration of late phases of the problem solution increased. Second, there was increased activation in the rostrolateral prefrontal cortex (RLPFC) and angular gyrus (AG), regions associated with metacognition. This indicates the importance of reflection to successful learning. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Aerobic and two-stage anaerobic-aerobic sludge digestion with pure oxygen and air aeration.

    PubMed

    Zupancic, Gregor D; Ros, Milenko

    2008-01-01

    The degradability of excess activated sludge from a wastewater treatment plant was studied. The objective was establishing the degree of degradation using either air or pure oxygen at different temperatures. Sludge treated with pure oxygen was degraded at temperatures from 22 degrees C to 50 degrees C while samples treated with air were degraded between 32 degrees C and 65 degrees C. Using air, sludge is efficiently degraded at 37 degrees C and at 50-55 degrees C. With oxygen, sludge was most effectively degraded at 38 degrees C or at 25-30 degrees C. Two-stage anaerobic-aerobic processes were studied. The first anaerobic stage was always operated for 5 days HRT, and the second stage involved aeration with pure oxygen and an HRT between 5 and 10 days. Under these conditions, there is 53.5% VSS removal and 55.4% COD degradation at 15 days HRT - 5 days anaerobic, 10 days aerobic. Sludge digested with pure oxygen at 25 degrees C in a batch reactor converted 48% of sludge total Kjeldahl nitrogen to nitrate. Addition of an aerobic stage with pure oxygen aeration to the anaerobic digestion enhances ammonium nitrogen removal. In a two-stage anaerobic-aerobic sludge digestion process within 8 days HRT of the aerobic stage, the removal of ammonium nitrogen was 85%.

  7. Nitrification and aerobic denitrification in anoxic-aerobic sequencing batch reactor.

    PubMed

    Alzate Marin, Juan C; Caravelli, Alejandro H; Zaritzky, Noemí E

    2016-01-01

    The aim of this study was to evaluate the feasibility of achieving nitrogen (N) removal using a lab-scale sequencing batch reactor (SBR) exposed to anoxic/aerobic (AN/OX) phases, focusing to achieve aerobic denitrification. This process will minimize emissions of N2O greenhouse gas. The effects of different operating parameters on the reactor performance were studied: cycle duration, AN/OX ratio, pH, dissolved oxygen concentration (DOC), and organic load. The highest inorganic N removal (NiR), close to 70%, was obtained at pH=7.5, low organic load (440mgCOD/(Lday)) and high aeration given by 12h cycle, AN/OX ratio=0.5:1.0 and DOC higher than 4.0mgO2/L. Nitrification followed by high-rate aerobic denitrification took place during the aerobic phase. Aerobic denitrification could be attributed to Tetrad-forming organisms (TFOs) with phenotype of glycogen accumulating organisms using polyhydroxyalkanoate and/or glycogen storage. The proposed AN/OX system constitutes an eco-friendly N removal process providing N2 as the end product.

  8. THE MOST LUMINOUS GALAXIES DISCOVERED BY WISE

    SciTech Connect

    Tsai, Chao-Wei; Eisenhardt, Peter R. M.; Stern, Daniel; Moustakas, Leonidas A.; Wu, Jingwen; Wright, Edward L.; Assef, Roberto J.; Blain, Andrew W.; Bridge, Carrie R.; Sayers, Jack; Benford, Dominic J.; Leisawitz, David T.; Cutri, Roc M.; Masci, Frank J.; Yan, Lin; Griffith, Roger L.; Jarrett, Thomas H.; Lonsdale, Carol J.; Petty, Sara M.; Stanford, S. Adam; and others

    2015-06-01

    We present 20 Wide-field Infrared Survey Explorer (WISE)-selected galaxies with bolometric luminosities L{sub bol} > 10{sup 14} L{sub ☉}, including five with infrared luminosities L{sub IR} ≡ L{sub (rest} {sub 8–1000} {sub μm)} > 10{sup 14} L{sub ☉}. These “extremely luminous infrared galaxies,” or ELIRGs, were discovered using the “W1W2-dropout” selection criteria which requires marginal or non-detections at 3.4 and 4.6 μm (W1 and W2, respectively) but strong detections at 12 and 22 μm in the WISE survey. Their spectral energy distributions are dominated by emission at rest-frame 4–10 μm, suggesting that hot dust with T{sub d} ∼ 450 K is responsible for the high luminosities. These galaxies are likely powered by highly obscured active galactic nuclei (AGNs), and there is no evidence suggesting these systems are beamed or lensed. We compare this WISE-selected sample with 116 optically selected quasars that reach the same L{sub bol} level, corresponding to the most luminous unobscured quasars in the literature. We find that the rest-frame 5.8 and 7.8 μm luminosities of the WISE-selected ELIRGs can be 30%–80% higher than that of the unobscured quasars. The existence of AGNs with L{sub bol} > 10{sup 14} L{sub ☉} at z > 3 suggests that these supermassive black holes are born with large mass, or have very rapid mass assembly. For black hole seed masses ∼10{sup 3} M{sub ☉}, either sustained super-Eddington accretion is needed, or the radiative efficiency must be <15%, implying a black hole with slow spin, possibly due to chaotic accretion.

  9. ROSAT Discovers Unique, Distant Cluster of Galaxies

    NASA Astrophysics Data System (ADS)

    1995-06-01

    Brightest X-ray Cluster Acts as Strong Gravitational Lens Based on exciting new data obtained with the ROSAT X-ray satellite and a ground-based telescope at the ESO La Silla Observatory, a team of European astronomers [2] has just discovered a very distant cluster of galaxies with unique properties. It emits the strongest X-ray emission of any cluster ever observed by ROSAT and is accompanied by two extraordinarily luminous arcs that represent the gravitationally deflected images of even more distant objects. The combination of these unusual characteristics makes this cluster, now known as RXJ1347.5-1145, a most interesting object for further cosmological studies. DISCOVERY AND FOLLOW-UP OBSERVATIONS This strange cluster of galaxies was discovered during the All Sky Survey with the ROSAT X-ray satellite as a moderately intense X-ray source in the constellation of Virgo. It could not be identified with any already known object and additional ground-based observations were therefore soon after performed with the Max-Planck-Society/ESO 2.2-metre telescope at the La Silla observatory in Chile. These observations took place within a large--scale redshift survey of X-ray clusters of galaxies detected by the ROSAT All Sky Survey, a so-called ``ESO Key Programme'' led by astronomers from the Max-Planck-Institut fur Extraterrestrische Physik and the Osservatorio Astronomico di Brera. The main aim of this programme is to identify cluster X-ray sources, to determine the distance to the X-ray emitting clusters and to investigate their overall properties. These observations permitted to measure the redshift of the RXJ1347.5-1145 cluster as z = 0.45, i.e. it moves away from us with a velocity (about 106,000 km/sec) equal to about one-third of the velocity of light. This is an effect of the general expansion of the universe and it allows to determine the distance as about 5,000 million light-years (assuming a Hubble constant of 75 km/sec/Mpc). In other words, we see these

  10. New variable stars discovered in the fields of three Galactic open clusters using the VVV survey

    NASA Astrophysics Data System (ADS)

    Palma, T.; Minniti, D.; Dékány, I.; Clariá, J. J.; Alonso-García, J.; Gramajo, L. V.; Ramírez Alegría, S.; Bonatto, C.

    2016-11-01

    This project is a massive near-infrared (NIR) search for variable stars in highly reddened and obscured open cluster (OC) fields projected on regions of the Galactic bulge and disk. The search is performed using photometric NIR data in the J-, H- and Ks- bands obtained from the Vista Variables in the Vía Láctea (VVV) Survey. We performed in each cluster field a variability search using Stetson's variability statistics to select the variable candidates. Later, those candidates were subjected to a frequency analysis using the Generalized Lomb-Scargle and the Phase Dispersion Minimization algorithms. The number of independent observations range between 63 and 73. The newly discovered variables in this study, 157 in total in three different known OCs, are classified based on their light curve shapes, periods, amplitudes and their location in the corresponding color-magnitude (J -Ks ,Ks) and color-color (H -Ks , J - H) diagrams. We found 5 possible Cepheid stars which, based on the period-luminosity relation, are very likely type II Cepheids located behind the bulge. Among the newly discovered variables, there are eclipsing binaries, δ Scuti, as well as background RR Lyrae stars. Using the new version of the Wilson & Devinney code as well as the "Physics Of Eclipsing Binaries" (PHOEBE) code, we analyzed some of the best eclipsing binaries we discovered. Our results show that these studied systems turn out to be ranging from detached to double-contact binaries, with low eccentricities and high inclinations of approximately 80°. Their surface temperatures range between 3500 K and 8000 K.

  11. Discovering Extrasolar Planets with Microlensing Surveys

    NASA Astrophysics Data System (ADS)

    Wambsganss, J.

    2016-06-01

    An astronomical survey is commonly understood as a mapping of a large region of the sky, either photometrically (possibly in various filters/wavelength ranges) or spectroscopically. Often, catalogs of objects are produced/provided as the main product or a by-product. However, with the advent of large CCD cameras and dedicated telescopes with wide-field imaging capabilities, it became possible in the early 1990s, to map the same region of the sky over and over again. In principle, such data sets could be combined to get very deep stacked images of the regions of interest. However, I will report on a completely different use of such repeated maps: Exploring the time domain for particular kinds of stellar variability, namely microlens-induced magnifications in search of exoplanets. Such a time-domain microlensing survey was originally proposed by Bohdan Paczynski in 1986 in order to search for dark matter objects in the Galactic halo. Only a few years later three teams started this endeavour. I will report on the history and current state of gravitational microlensing surveys. By now, routinely 100 million stars in the Galactic Bulge are monitored a few times per week by so-called survey teams. All stars with constant apparent brightness and those following known variability patterns are filtered out in order to detect the roughly 2000 microlensing events per year which are produced by stellar lenses. These microlensing events are identified "online" while still in their early phases and then monitored with much higher cadence by so-called follow-up teams. The most interesting of such events are those produced by a star-plus-planet lens. By now of order 30 exoplanets have been discovered by these combined microlensing surveys. Microlensing searches for extrasolar planets are complementary to other exoplanet search techniques. There are two particular advantages: The microlensing method is sensitive down to Earth-mass planets even with ground-based telecopes, and it

  12. The Impact of Discovering Life beyond Earth

    NASA Astrophysics Data System (ADS)

    Dick, Steven J.

    2016-01-01

    Introduction: astrobiology and society Steven J. Dick; Part I. Motivations and Approaches. How Do We Frame the Problems of Discovery and Impact?: Introduction; 1. Current approaches to finding life beyond earth, and what happens if we do Seth Shostak; 2. The philosophy of astrobiology: the Copernican and Darwinian presuppositions Iris Fry; 3. History, discovery, analogy: three approaches to the impact of discovering life beyond earth Steven J. Dick; 4. Silent impact: why the discovery of extraterrestrial life should be silent Clément Vidal; Part II. Transcending Anthropocentrism. How Do We Move beyond our Own Preconceptions of Life, Intelligence and Culture?: Introduction; 5. The landscape of life Dirk Schulze-Makuch; 6. The landscape of intelligence Lori Marino; 7. Universal biology: assessing universality from a single example Carlos Mariscal; 8. Equating culture, civilization, and moral development in imagining extraterrestrial intelligence: anthropocentric assumptions? John Traphagan; 9. Communicating with the other: infinity, geometry, and universal math and science Douglas Vakoch; Part III. Philosophical, Theological, and Moral Impact. How Do We Comprehend the Cultural Challenges Raised by Discovery?: Introduction; 10. Life, intelligence and the pursuit of value in cosmic evolution Mark Lupisella; 11. 'Klaatu barada nikto' - or, do they really think like us? Michael Ruse; 12. Alien minds Susan Schneider; 13. The moral subject of astrobiology: guideposts for exploring our ethical and political responsibilities towards extraterrestrial life Elspeth Wilson and Carol Cleland; 14. Astrobiology and theology Robin Lovin; 15. Would you baptize an extraterrestrial? Guy Consolmagno, SJ; Part IV. Practical Considerations: How Should Society Prepare for Discovery - and Non-Discovery?: Introduction; 16. Is there anything new about astrobiology and society? Jane Maienschein; 17. Evaluating preparedness for the discovery of extraterrestrial life: considering potential

  13. PSLQ: An Algorithm to Discover Integer Relations

    SciTech Connect

    Bailey, David H.; Borwein, J. M.

    2009-04-03

    Let x = (x{sub 1}, x{sub 2} {hor_ellipsis}, x{sub n}) be a vector of real or complex numbers. x is said to possess an integer relation if there exist integers a{sub i}, not all zero, such that a{sub 1}x{sub 1} + a{sub 2}x{sub 2} + {hor_ellipsis} + a{sub n}x{sub n} = 0. By an integer relation algorithm, we mean a practical computational scheme that can recover the vector of integers ai, if it exists, or can produce bounds within which no integer relation exists. As we will see in the examples below, an integer relation algorithm can be used to recognize a computed constant in terms of a formula involving known constants, or to discover an underlying relation between quantities that can be computed to high precision. At the present time, the most effective algorithm for integer relation detection is the 'PSLQ' algorithm of mathematician-sculptor Helaman Ferguson [10, 4]. Some efficient 'multi-level' implementations of PSLQ, as well as a variant of PSLQ that is well-suited for highly parallel computer systems, are given in [4]. PSLQ constructs a sequence of integer-valued matrices B{sub n} that reduces the vector y = xB{sub n}, until either the relation is found (as one of the columns of B{sub n}), or else precision is exhausted. At the same time, PSLQ generates a steadily growing bound on the size of any possible relation. When a relation is found, the size of smallest entry of the vector y abruptly drops to roughly 'epsilon' (i.e. 10{sup -p}, where p is the number of digits of precision). The size of this drop can be viewed as a 'confidence level' that the relation is real and not merely a numerical artifact - a drop of 20 or more orders of magnitude almost always indicates a real relation. Very high precision arithmetic must be used in PSLQ. If one wishes to recover a relation of length n, with coefficients of maximum size d digits, then the input vector x must be specified to at least nd digits, and one must employ nd-digit floating-point arithmetic. Maple and

  14. Galactic supernova remnant candidates discovered by THOR

    NASA Astrophysics Data System (ADS)

    Anderson, L. D.; Wang, Y.; Bihr, S.; Rugel, M.; Beuther, H.; Bigiel, F.; Churchwell, E.; Glover, S. C. O.; Goodman, A. A.; Henning, Th.; Heyer, M.; Klessen, R. S.; Linz, H.; Longmore, S. N.; Menten, K. M.; Ott, J.; Roy, N.; Soler, J. D.; Stil, J. M.; Urquhart, J. S.

    2017-09-01

    Context. There is a considerable deficiency in the number of known supernova remnants (SNRs) in the Galaxy compared to that expected. This deficiency is thought to be caused by a lack of sensitive radio continuum data. Searches for extended low-surface brightness radio sources may find new Galactic SNRs, but confusion with the much larger population of H ii regions makes identifying such features challenging. SNRs can, however, be separated from H ii regions using their significantly lower mid-infrared (MIR) to radio continuum intensity ratios. Aims: Our goal is to find missing SNR candidates in the Galactic disk by locating extended radio continuum sources that lack MIR counterparts. Methods: We use the combination of high-resolution 1-2 GHz continuum data from The HI, OH, Recombination line survey of the Milky Way (THOR) and lower-resolution VLA 1.4 GHz Galactic Plane Survey (VGPS) continuum data, together with MIR data from the Spitzer GLIMPSE, Spitzer MIPSGAL, and WISE surveys to identify SNR candidates. To ensure that the candidates are not being confused with H ii regions, we exclude radio continuum sources from the WISE Catalog of Galactic H ii Regions, which contains all known and candidate H ii regions in the Galaxy. Results: We locate 76 new Galactic SNR candidates in the THOR and VGPS combined survey area of 67.4° > ℓ > 17.5°, | b | ≤ 1.25° and measure the radio flux density for 52 previously-known SNRs. The candidate SNRs have a similar spatial distribution to the known SNRs, although we note a large number of new candidates near ℓ ≃ 30°, the tangent point of the Scutum spiral arm. The candidates are on average smaller in angle compared to the known regions, 6.4' ± 4.7' versus 11.0' ± 7.8', and have lower integrated flux densities. Conclusions: The THOR survey shows that sensitive radio continuum data can discover a large number of SNR candidates, and that these candidates can be efficiently identified using the combination of radio and

  15. [Cardiovascular protection and mechanisms of actions of aerobic exercise].

    PubMed

    Hou, Zuo-Xu; Zhang, Yuan; Gao, Feng

    2014-08-01

    It is well established that aerobic exercise exerts beneficial effect on cardiovascular system, but the underlying mechanisms are yet to be elucidated. Recent studies have shown that aerobic exercise ameliorates insulin resistance, inflammation and mitochondrial dysfunction which play important roles in the development of cardiovascular disease. In this review, we discussed the underlying mechanisms of the cardioprotective role of aerobic exercise, especially the latest progress in this field.

  16. [Sulfa-drug wastewater treatment with anaerobic/aerobic process].

    PubMed

    Wu, L; Zhang, H; Zhu, H; Zhang, Z; Zhuang, Y; Dai, S

    2001-09-01

    Sulfa drug wastewater was treated with anaerobic/aerobic process. The removal ratios of TOC reached about 50% in anaerobic phase and about 70% in aerobic phase respectively, while volume loading rate of TOC was about 1.2 kg/(m3.d) in anaerobic phase and about 0.6 kg/(m3.d) in aerobic phase. Removal of TOC in anaerobic phase was attributed to the reduction of sulfate.

  17. ESA's Integral discovers hidden black holes

    NASA Astrophysics Data System (ADS)

    2003-10-01

    discovered so far? Astronomers, who have been observing the object regularly, guess that it had remained invisible because there must be a very thick shell of obscuring material surrounding it. If that was the case, only the most energetic radiation from the object could get through the shell; less-energetic radiation would be blocked. That could explain why space telescopes that are sensitive only to low-energy radiation had overlooked the object, while Integral, specialised in detecting very energetic emissions, did see it. To test their theory, astronomers turned to ESA's XMM-Newton space observatory, which observes the sky in the X-ray wavelengths. As well as being sensitive to high-energy radiation, XMM-Newton is also able to check for the presence of obscuring material. Indeed, XMM-Newton detected this object last February, as well as the existence of a dense 'cocoon' of cold gas with a diameter of similar size to that of the Earth's orbit around the Sun. This obscuring material forming the cocoon is probably 'stellar wind', namely gas ejected by the supermassive companion star. Astronomers think that this gas may be accreted by the compact black hole, forming a dense shell around it. This obscuring cloud traps most of the energy produced inside it. The main author of these results, Roland Walter of the Integral Science Data Centre, Switzerland, explained: "Only photons with the highest energies [above 10 keV] could escape from that cocoon. IGR J16318-4848 has therefore not been detected by surveys performed at lower energies, nor by previous gamma-ray missions that were much less sensitive than Integral." The question now is to find out how many of these objects lurk in the Galaxy. XMM-Newton and Integral together are the perfect tools to do the job. They have already discovered two more new sources embedded in obscuring material. Future observations are planned. Christoph Winkler, ESA Project Scientist for Integral, said: "These early examples of using two

  18. Morbillivirus infections of aquatic mammals: newly identified members of the genus.

    PubMed

    Osterhaus, A D; de Swart, R L; Vos, H W; Ross, P S; Kenter, M J; Barrett, T

    1995-05-01

    Several disease outbreaks, which have caused the deaths of many thousands of seals and dolphins during the last decade, have now been attributed to infections with newly identified Morbilliviruses. Outbreaks in the late eighties amongst harbour seals (Phoca vitulina) and grey seals (Halichoerus grypus) in northwestern Europe and amongst baikal seals (Phoca sibirica) in Siberia were caused by the newly discovered phocine distemper virus and by a strain of canine distemper virus, respectively. Although closely related these two viruses were not identical. They were more distantly related to the viruses which caused mass mortality amongst striped dolphins (Stenella coeruleoalba) in the Mediterranean sea in the early nineties. This dolphin morbillivirus was shown to be closely related to a virus that was found in harbour porpoises (Phocoena phocoena) which had stranded at the coasts of northwestern Europe in the late eighties: porpoise morbillivirus. The present knowledge of the genetic and antigenic relationships of these apparently new members of the genus Morbillivirus with the established members of the genus is presented. In addition, the origin and epizootiological aspects of these newly discovered viruses are discussed. Finally experimental evidence that environmental pollution may have contributed to the severity and extent of these infections in recent years is presented.

  19. Skeletal myopathy in heart failure: effects of aerobic exercise training.

    PubMed

    Brum, P C; Bacurau, A V; Cunha, T F; Bechara, L R G; Moreira, J B N

    2014-04-01

    Reduced aerobic capacity, as measured by maximal oxygen uptake, is a hallmark in cardiovascular diseases and strongly predicts poor prognosis and higher mortality rates in heart failure patients. While exercise capacity is poorly correlated with cardiac function in this population, skeletal muscle abnormalities present a striking association with maximal oxygen uptake. This fact draws substantial attention to the clinical relevance of targeting skeletal myopathy in heart failure. Considering that skeletal muscle is highly responsive to aerobic exercise training, we addressed the benefits of aerobic exercise training to combat skeletal myopathy in heart failure, focusing on the mechanisms by which aerobic exercise training counteracts skeletal muscle atrophy.

  20. Aerobic capacity and its correlates in patients with ankylosing spondylitis.

    PubMed

    Hsieh, Lin-Fen; Wei, James Cheng-Chung; Lee, Hsin-Yi; Chuang, Chih-Cheng; Jiang, Jiunn-Song; Chang, Kae-Chwen

    2016-05-01

    To evaluate aerobic capacity in patients with ankylosing spondylitis (AS) and determine possible relationships between aerobic capacity, pulmonary function, and disease-related variables. Forty-two patients with AS and 42 healthy controls were recruited in the study. Descriptive data, disease-related variables (grip strength, lumbosacral mobility, occiput-to-wall distance, chest expansion, finger-to-floor distance, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Global Score, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and hemoglobin), and chest and thoracic spine x-rays were collected in each patient with AS. All subjects took standard pulmonary function and exercise tolerance tests, and forced vital capacity (FVC) and aerobic capacity were recorded. Both aerobic capacity and FVC in patients with AS were significantly lower than those in normal subjects (P < 0.05). AS patients with BASFI scores of < 3 or BASDI scores of < 4 had a higher aerobic capacity. There was significant correlation between aerobic capacity, vital capacity, chest expansion, Schober's test, cervical range of motion, and BASFI in patients with AS. Neither aerobic capacity nor vital capacity correlated with disease duration, ESR, CRP, and hemoglobin. Significantly reduced aerobic capacity and FVC were observed in patients with AS, and there was significant correlation between aerobic capacity, vital capacity, chest expansion, and BASFI. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.