Enhancement of the Open National Combustion Code (OpenNCC) and Initial Simulation of Energy Efficient Engine Combustor

NASA Technical Reports Server (NTRS)

Miki, Kenji; Moder, Jeff; Liou, Meng-Sing

2016-01-01

In this paper, we present the recent enhancement of the Open National Combustion Code (OpenNCC) and apply the OpenNCC to model a realistic combustor configuration (Energy Efficient Engine (E3)). First, we perform a series of validation tests for the newly-implemented advection upstream splitting method (AUSM) and the extended version of the AUSM-family schemes (AUSM+-up). Compared with the analytical/experimental data of the validation tests, we achieved good agreement. In the steady-state E3 cold flow results using the Reynolds-averaged Navier-Stokes(RANS), we find a noticeable difference in the flow fields calculated by the two different numerical schemes, the standard Jameson- Schmidt-Turkel (JST) scheme and the AUSM scheme. The main differences are that the AUSM scheme is less numerical dissipative and it predicts much stronger reverse flow in the recirculation zone. This study indicates that two schemes could show different flame-holding predictions and overall flame structures.

MVAPACK: A Complete Data Handling Package for NMR Metabolomics

PubMed Central

2015-01-01

Data handling in the field of NMR metabolomics has historically been reliant on either in-house mathematical routines or long chains of expensive commercial software. Thus, while the relatively simple biochemical protocols of metabolomics maintain a low barrier to entry, new practitioners of metabolomics experiments are forced to either purchase expensive software packages or craft their own data handling solutions from scratch. This inevitably complicates the standardization and communication of data handling protocols in the field. We report a newly developed open-source platform for complete NMR metabolomics data handling, MVAPACK, and describe its application on an example metabolic fingerprinting data set. PMID:24576144

Cyber-physical geographical information service-enabled control of diverse in-situ sensors.

PubMed

Chen, Nengcheng; Xiao, Changjiang; Pu, Fangling; Wang, Xiaolei; Wang, Chao; Wang, Zhili; Gong, Jianya

2015-01-23

Realization of open online control of diverse in-situ sensors is a challenge. This paper proposes a Cyber-Physical Geographical Information Service-enabled method for control of diverse in-situ sensors, based on location-based instant sensing of sensors, which provides closed-loop feedbacks. The method adopts the concepts and technologies of newly developed cyber-physical systems (CPSs) to combine control with sensing, communication, and computation, takes advantage of geographical information service such as services provided by the Tianditu which is a basic geographic information service platform in China and Sensor Web services to establish geo-sensor applications, and builds well-designed human-machine interfaces (HMIs) to support online and open interactions between human beings and physical sensors through cyberspace. The method was tested with experiments carried out in two geographically distributed scientific experimental fields, Baoxie Sensor Web Experimental Field in Wuhan city and Yemaomian Landslide Monitoring Station in Three Gorges, with three typical sensors chosen as representatives using the prototype system Geospatial Sensor Web Common Service Platform. The results show that the proposed method is an open, online, closed-loop means of control.

Cyber-Physical Geographical Information Service-Enabled Control of Diverse In-Situ Sensors

PubMed Central

Chen, Nengcheng; Xiao, Changjiang; Pu, Fangling; Wang, Xiaolei; Wang, Chao; Wang, Zhili; Gong, Jianya

2015-01-01

Realization of open online control of diverse in-situ sensors is a challenge. This paper proposes a Cyber-Physical Geographical Information Service-enabled method for control of diverse in-situ sensors, based on location-based instant sensing of sensors, which provides closed-loop feedbacks. The method adopts the concepts and technologies of newly developed cyber-physical systems (CPSs) to combine control with sensing, communication, and computation, takes advantage of geographical information service such as services provided by the Tianditu which is a basic geographic information service platform in China and Sensor Web services to establish geo-sensor applications, and builds well-designed human-machine interfaces (HMIs) to support online and open interactions between human beings and physical sensors through cyberspace. The method was tested with experiments carried out in two geographically distributed scientific experimental fields, Baoxie Sensor Web Experimental Field in Wuhan city and Yemaomian Landslide Monitoring Station in Three Gorges, with three typical sensors chosen as representatives using the prototype system Geospatial Sensor Web Common Service Platform. The results show that the proposed method is an open, online, closed-loop means of control. PMID:25625906

The new high field photoexcitation muon spectrometer at the ISIS pulsed neutron and muon source

NASA Astrophysics Data System (ADS)

Yokoyama, K.; Lord, J. S.; Murahari, P.; Wang, K.; Dunstan, D. J.; Waller, S. P.; McPhail, D. J.; Hillier, A. D.; Henson, J.; Harper, M. R.; Heathcote, P.; Drew, A. J.

2016-12-01

A high power pulsed laser system has been installed on the high magnetic field muon spectrometer (HiFi) at the International Science Information Service pulsed neutron and muon source, situated at the STFC Rutherford Appleton Laboratory in the UK. The upgrade enables one to perform light-pump muon-probe experiments under a high magnetic field, which opens new applications of muon spin spectroscopy. In this report we give an overview of the principle of the HiFi laser system and describe the newly developed techniques and devices that enable precisely controlled photoexcitation of samples in the muon instrument. A demonstration experiment illustrates the potential of this unique combination of the photoexcited system and avoided level crossing technique.

The new high field photoexcitation muon spectrometer at the ISIS pulsed neutron and muon source.

PubMed

Yokoyama, K; Lord, J S; Murahari, P; Wang, K; Dunstan, D J; Waller, S P; McPhail, D J; Hillier, A D; Henson, J; Harper, M R; Heathcote, P; Drew, A J

2016-12-01

A high power pulsed laser system has been installed on the high magnetic field muon spectrometer (HiFi) at the International Science Information Service pulsed neutron and muon source, situated at the STFC Rutherford Appleton Laboratory in the UK. The upgrade enables one to perform light-pump muon-probe experiments under a high magnetic field, which opens new applications of muon spin spectroscopy. In this report we give an overview of the principle of the HiFi laser system and describe the newly developed techniques and devices that enable precisely controlled photoexcitation of samples in the muon instrument. A demonstration experiment illustrates the potential of this unique combination of the photoexcited system and avoided level crossing technique.

Quality of life in newly diagnosed glaucoma patients : The Collaborative Initial Glaucoma Treatment Study.

PubMed

Janz, N K; Wren, P A; Lichter, P R; Musch, D C; Gillespie, B W; Guire, K E

2001-05-01

The Collaborative Initial Glaucoma Treatment Study (CIGTS) was designed to determine whether patients with newly diagnosed open-angle glaucoma are better treated initially by medicine or immediate filtering surgery. This paper describes the quality-of-life (QOL) measurement approach, instruments included, and the CIGTS participants' QOL findings at the time of diagnosis. Baseline results from a randomized, controlled clinical trial. Six hundred seven patients from 14 clinical centers were enrolled. Patients randomized to initial medication received a stepped medical regimen (n = 307). Those randomized to initial surgery underwent a trabeculectomy (n = 300). The baseline interview was conducted before treatment initiation. All baseline and posttreatment QOL assessments were conducted by telephone from a centralized interviewing center. The primary outcome measure described in this paper was QOL. The QOL instrument is multidimensional and incorporates both disease-specific and generic measures, including the Visual Activities Questionnaire, Sickness Impact Profile, and a Symptom and Health Problem CHECKLIST: The correlations between QOL measures and clinical outcomes were in the expected direction, but relatively weak. At initial diagnosis, difficulty with bright lights and with light and dark adaptation were the most frequently reported symptoms related to visual function, whereas visual distortion was the most bothersome. Approximately half of the patients reported at least some worry or concern about the possibility of blindness. Within the Visual Activities Questionnaire, higher scores on the Peripheral Vision subscale were associated with more field loss (P < 0.01). In regression analyses controlling for sociodemographics and nonocular comorbidities, increased visual field loss was significantly associated with higher dysfunction among five disease-specific QOL measures (P < 0.05). Newly diagnosed glaucoma patients reported experiencing some visual function symptoms at the time of diagnosis that would not be intuitively expected based on clinical testing. Some discussion about the association between clinical presentation and worry about blindness may reduce unnecessary concern. These results provide the basis for long-term comparisons of the QOL effects of initial medical and surgical treatment for open-angle glaucoma.

A novel electrostatic ion-energy spectrometer by the use of a proposed ``self-collection'' method for secondary-electron emission from a metal collector

NASA Astrophysics Data System (ADS)

Hirata, M.; Nagashima, S.; Cho, T.; Kohagura, J.; Yoshida, M.; Ito, H.; Numakura, T.; Minami, R.; Kondoh, T.; Nakashima, Y.; Yatsu, K.; Miyoshi, S.

2003-03-01

For the purpose of end-loss-ion energy analyses in open-field plasmas, a newly developed electrostatic ion-energy spectrometer is proposed on the basis of a "self-collection" principle for secondary-electron emission from a metal collector. The ion-energy spectrometer is designed with multiple grids for analyzing incident ion energies, and a set of parallelly placed metal plates with respect to lines of ambient magnetic forces in an open-ended device. One of the most important characteristic properties of this spectrometer is the use of our proposed principle of a "self-collection" mechanism due to E×B drifts for secondary electrons emitted from the grounded metal-plate collector by the use of no further additional magnetic systems except the ambient open-ended fields B. The proof-of-principle and characterization experiments are carried out by the use of a test-ion-beam line along with an additional use of a Helmholtz coil system for the formation of open magnetic fields similar to those in the GAMMA 10 end region. The applications of the developed ion-energy spectrometer for end-loss-ion diagnostics in the GAMMA 10 plasma experiments are demonstrated under the conditions with simultaneous incidence of energetic electrons produced by electron-cyclotron heatings for end-loss-plugging potential formation, since these electrons have contributed to disturb these ion signals from conventional end-loss-ion detectors.

Newly Developed Techniques on Polycondensation, Ring-Opening Polymerization and Polymer Modification: Focus on Poly(Lactic Acid)

PubMed Central

Hu, Yunzi; Daoud, Walid A.; Cheuk, Kevin Ka Leung; Lin, Carol Sze Ki

2016-01-01

Polycondensation and ring-opening polymerization are two important polymer synthesis methods. Poly(lactic acid), the most typical biodegradable polymer, has been researched extensively from 1900s. It is of significant importance to have an up-to-date review on the recent improvement in techniques for biodegradable polymers. This review takes poly(lactic acid) as the example to present newly developed polymer synthesis techniques on polycondensation and ring-opening polymerization reported in the recent decade (2005–2015) on the basis of industrial technique modifications and advanced laboratory research. Different polymerization methods, including various solvents, heating programs, reaction apparatus and catalyst systems, are summarized and compared with the current industrial production situation. Newly developed modification techniques for polymer properties improvement are also discussed based on the case of poly(lactic acid). PMID:28773260

Direct writing of room temperature and zero field skyrmion lattices by a scanning local magnetic field

NASA Astrophysics Data System (ADS)

Zhang, Senfu; Zhang, Junwei; Zhang, Qiang; Barton, Craig; Neu, Volker; Zhao, Yuelei; Hou, Zhipeng; Wen, Yan; Gong, Chen; Kazakova, Olga; Wang, Wenhong; Peng, Yong; Garanin, Dmitry A.; Chudnovsky, Eugene M.; Zhang, Xixiang

2018-03-01

Magnetic skyrmions are topologically protected nanoscale spin textures exhibiting fascinating physical behaviors. Recent observations of room temperature skyrmions in sputtered multilayer films are an important step towards their use in ultra-low power devices. Such practical applications prefer skyrmions to be stable at zero magnetic fields and room temperature. Here, we report the creation of skyrmion lattices in Pt/Co/Ta multilayers by a scanning local field using magnetic force microscopy tips. We also show that those newly created skyrmion lattices are stable at both room temperature and zero fields. Lorentz transmission electron microscopy measurements reveal that the skyrmions in our films are of Néel-type. To gain a deeper understanding of the mechanism behind the creation of a skyrmion lattice by the scanning of local fields, we perform micromagnetic simulations and find the experimental results to be in agreement with our simulation data. This study opens another avenue for the creation of skyrmion lattices in thin films.

Is an electric field always a promoter of wetting? Electro-dewetting of metals by electrolytes probed by in situ X-ray nanotomography

DOE PAGES

Nave, Maryana I.; Gu, Yu; Karen Chen-Wiegart, Yu-Chen; ...

2017-01-05

We developed a special electrochemical cell enabling quantitative analysis andin situX-ray nanotomography of metal/electrolyte interfaces subject to corrosion. Using this cell and applying the nodoid model to describe menisci formed on tungsten wires during anodization, the evolution of the electrolyte surface tension, the concentration of reaction products, and the meniscus contact angle were studied. In contrast to the electrowetting effect, where the applied electric field decreases the contact angle of electrolytes, anodization of the tungsten wires increases the contact angle of the meniscus. Hence, an electric field favors dewetting rather than wetting of the newly formed surface. Finally, the discoveredmore » effect opens up new opportunities for the control of wetting phenomena and calls for the revision of existing theories of electrowetting.« less

The Galileo Teacher Training Program Global Efforts

NASA Astrophysics Data System (ADS)

Doran, R.; Pennypacker, C.; Ferlet, R.

2012-08-01

The Galileo Teacher Training Program (GTTP) successfully named representatives in nearly 100 nations in 2009, the International Year of Astronomy (IYA2009). The challenge had just begun. The steps ahead are how to reach educators that might benefit from our program and how to help build a more fair and science literate society, a society in which good tools and resources for science education are not the privilege of a few. From 2010 on our efforts have been to strengthen the newly formed network and learn how to equally help educators and students around the globe. New partnerships with other strong programs and institutions are being formed, sponsorship schemes being outlined, new tools and resources being publicized, and on-site and video conference training conducted all over the world. Efforts to officially accredit a GTTP curriculum are on the march and a stronger certification process being outlined. New science topics are being integrated in our effort and we now seek to discuss the path ahead with experts in this field and the community of users, opening the network to all corners of our beautiful blue dot. The main aim of this article is to open the discussion regarding the urgent issue of how to reawaken student interest in science, how to solve the gender inequality in science careers, and how to reach the underprivileged students and open to them the same possibilities. Efforts are in strengthening the newly formed network and learning how to equally help educators and students around the globe.

New Open-Source Version of FLORIS Released | News | NREL

Science.gov Websites

New Open-Source Version of FLORIS Released New Open-Source Version of FLORIS Released January 26 , 2018 National Renewable Energy Laboratory (NREL) researchers recently released an updated open-source simplified and documented. Because of the living, open-source nature of the newly updated utility, NREL

An expanded map of vegetation communities at Big Muddy National Fish and Wildlife Refuge

USGS Publications Warehouse

Struckhoff, Matthew A.

2013-01-01

In 2012, a map of vegetation communities on Big Muddy National Fish and Wildlife Refuge was expanded based on interpretation of aerial photographs and field data. National Agricultural Imagery Program aerial photographs were used to identify distinct communities on previously unmapped refuge units and newly acquired parcels. Newly mapped polygons were then visited to adjust map boundaries, classify communities according to the National Vegetation Classification System, and quantify the abundance of dominant species and non-native, invasive species of concern to the refuge and other resource management agencies along the Missouri River. The expanded map now covers 6,136 hectares representing 33 community types, including 6 previously unmapped types. The full map includes 1,113 polygons, of which 627 are new, 21 are updated from the 2009 mapping effort, and 465 are unchanged from 2009. Mortality of primarily cottonwood stems, because of growing-season floods between 2008 and 2011, has reduced foliar cover of woody stems and created more open wooded communities. In herbaceous communities, dominance by herbaceous old fields has increased due to the inclusion of refuge units dominated by lands in recent agricultural production in the expanded map. Wetland community abundance has increased slightly due to recent flooding.

Web-based stress management for newly diagnosed cancer patients (STREAM-1): a randomized, wait-list controlled intervention study.

PubMed

Grossert, Astrid; Urech, Corinne; Alder, Judith; Gaab, Jens; Berger, Thomas; Hess, Viviane

2016-11-03

Being diagnosed with cancer causes major psychological distress, yet the majority of newly diagnosed cancer patients lack psychological support. Internet interventions overcome many barriers for seeking face-to-face support and allow for independence in time and place. We assess efficacy and feasibility of the first web-based stress management intervention (STREAM: STREss-Aktiv-Mindern) for newly diagnosed, German-speaking cancer patients. In a prospective, wait-list controlled trial 120 newly diagnosed cancer patients will be included within 12 weeks of starting anti-cancer treatment and randomized between an immediate (intervention group) or delayed (control group) 8-week, web-based intervention. The intervention consists of eight modules with weekly written feedback by a psychologist ("minimal-contact") based on well-established stress management manuals including downloadable audio-files and exercises. The aim of this study is to evaluate efficacy in terms of improvement in quality of life (FACT-F), as well as decrease in anxiety and depression (HADS), as compared to patients in the wait-list control group. A sample size of 120 patients allows demonstrating a clinically relevant difference of nine points in the FACT score after the intervention (T2) with a two-sided alpha of 0.05 and 80 % power. As this is the first online stress management intervention for German-speaking cancer patients, more descriptive outcomes are equally important to further refine the group of patients with the largest potential for benefit who then will be targeted more specifically in future trials. These descriptive endpoints include: patients' characteristics (type of cancer, type of treatment, socio-demographic factors), dropout rate and dropout reasons, adherence and satisfaction with the program. New technologies open new opportunities: minimal-contact psychological interventions are becoming standard of care in several psychological disorders, where their efficacy is often comparable to face-to-face interventions. With our study we open this field to the population of newly diagnosed cancer patients. We will not only assess clinical efficacy but also further refine the target population who has the most potential to benefit. An internet-based minimal-contact stress management program might be an attractive, time- and cost-effective way to effectively deliver psychological support to newly diagnosed cancer patients and an opportunity to include those who currently are not reached by conventional support. ClinicalTrials.gov NCT02289014 .

Charge and Spin Currents in Open-Shell Molecules:  A Unified Description of NMR and EPR Observables.

PubMed

Soncini, Alessandro

2007-11-01

The theory of EPR hyperfine coupling tensors and NMR nuclear magnetic shielding tensors of open-shell molecules in the limit of vanishing spin-orbit coupling (e.g., for organic radicals) is analyzed in terms of spin and charge current density vector fields. The ab initio calculation of the spin and charge current density response has been implemented at the Restricted Open-Shell Hartree-Fock, Unrestricted Hartree-Fock, and unrestricted GGA-DFT level of theory. On the basis of this formalism, we introduce the definition of nuclear hyperfine coupling density, a scalar function of position providing a partition of the EPR observable over the molecular domain. Ab initio maps of spin and charge current density and hyperfine coupling density for small radicals are presented and discussed in order to illustrate the interpretative advantages of the newly introduced approach. Recent NMR experiments providing evidence for the existence of diatropic ring currents in the open-shell singlet pancake-bonded dimer of the neutral phenalenyl radical are directly assessed via the visualization of the induced current density.

Solar Polar Jets Driven by Magnetic Reconnection, Gravity, and Wind

NASA Astrophysics Data System (ADS)

DeVore, C. Richard; Karpen, Judith T.; Antiochos, Spiro K.

2014-06-01

Polar jets are dynamic, narrow, radially extended structures observed in solar EUV emission near the limb. They originate within the open field of coronal holes in “anemone” regions, which are intrusions of opposite magnetic polarity. The key topological feature is a magnetic null point atop a dome-shaped fan surface of field lines. Applied stresses readily distort the null into a current patch, eventually inducing interchange reconnection between the closed and open fields inside and outside the fan surface (Antiochos 1996). Previously, we demonstrated that magnetic free energy stored on twisted closed field lines inside the fan surface is released explosively by the onset of fast reconnection across the current patch (Pariat et al. 2009, 2010). A dense jet comprised of a nonlinear, torsional Alfvén wave is ejected into the outer corona along the newly reconnected open field lines. Now we are extending those exploratory simulations by including the effects of solar gravity, solar wind, and expanding spherical geometry. We find that the model remains robust in the resulting more complex setting, with explosive energy release and dense jet formation occurring in the low corona due to the onset of a kink-like instability, as found in the earlier Cartesian, gravity-free, static-atmosphere cases. The spherical-geometry jet including gravity and wind propagates far more rapidly into the outer corona and inner heliosphere than a comparison jet simulation that excludes those effects. We report detailed analyses of our new results, compare them with previous work, and discuss the implications for understanding remote and in-situ observations of solar polar jets.This work was supported by NASA’s LWS TR&T program.

Staufen2 deficiency leads to impaired response to novelty in mice.

PubMed

Popper, Bastian; Demleitner, Antonia; Bolivar, Valerie J; Kusek, Gretchen; Snyder-Keller, Abigail; Schieweck, Rico; Temple, Sally; Kiebler, Michael A

2018-04-01

Staufen2 (Stau2) is a double-stranded RNA-binding protein (RBP) involved in posttranscriptional gene expression control in neurons. In flies, staufen contributes to learning and long-term memory formation. To study the impact of mammalian Stau2 on behavior, we generated a novel gene-trap mouse model that yields significant constitutive downregulation of Stau2 (Stau2 GT ). In order to investigate the effect of Stau2 downregulation on hippocampus-dependent behavior, we performed a battery of behavioral assays, i.e. open field, novel object recognition/location (NOR/L) and Barnes maze. Stau2 GT mice displayed reduced locomotor activity in the open field and altered novelty preference in the NOR and NOL paradigms. Adult Stau2 GT male mice failed to discriminate between familiar and newly introduced objects but showed enhanced spatial novelty detection. Additionally, we observed deficits in discriminating different spatial contexts in a Barnes maze assay. Together, our data suggest that Stau2 contributes to novelty preference and explorative behavior that is a driver for proper spatial learning in mice. Copyright © 2018 Elsevier Inc. All rights reserved.

Case Study: Applying OpenEHR Archetypes to a Clinical Data Repository in a Chinese Hospital.

PubMed

Min, Lingtong; Wang, Li; Lu, Xudong; Duan, Huilong

2015-01-01

openEHR is a flexible and scalable modeling methodology for clinical information and has been widely adopted in Europe and Australia. Due to the reasons of differences in clinical process and management, there are few research projects involving openEHR in China. To investigate the feasibility of openEHR methodology for clinical information modelling in China, this paper carries out a case study to apply openEHR archetypes to Clinical Data Repository (CDR) in a Chinese hospital. The results show that a set of 26 archetypes are found to cover all the concepts used in the CDR. Of all these, 9 (34.6%) are reused without change, 10 are modified and/or extended, and 7 are newly defined. The reasons for modification, extension and newly definition have been discussed, including granularity of archetype, metadata-level versus data-level modelling, and the representation of relationships between archetypes.

Precipitation-generated oscillations in open cellular cloud fields.

PubMed

Feingold, Graham; Koren, Ilan; Wang, Hailong; Xue, Huiwen; Brewer, Wm Alan

2010-08-12

Cloud fields adopt many different patterns that can have a profound effect on the amount of sunlight reflected back to space, with important implications for the Earth's climate. These cloud patterns can be observed in satellite images of the Earth and often exhibit distinct cell-like structures associated with organized convection at scales of tens of kilometres. Recent evidence has shown that atmospheric aerosol particles-through their influence on precipitation formation-help to determine whether cloud fields take on closed (more reflective) or open (less reflective) cellular patterns. The physical mechanisms controlling the formation and evolution of these cells, however, are still poorly understood, limiting our ability to simulate realistically the effects of clouds on global reflectance. Here we use satellite imagery and numerical models to show how precipitating clouds produce an open cellular cloud pattern that oscillates between different, weakly stable states. The oscillations are a result of precipitation causing downward motion and outflow from clouds that were previously positively buoyant. The evaporating precipitation drives air down to the Earth's surface, where it diverges and collides with the outflows of neighbouring precipitating cells. These colliding outflows form surface convergence zones and new cloud formation. In turn, the newly formed clouds produce precipitation and new colliding outflow patterns that are displaced from the previous ones. As successive cycles of this kind unfold, convergence zones alternate with divergence zones and new cloud patterns emerge to replace old ones. The result is an oscillating, self-organized system with a characteristic cell size and precipitation frequency.

Visual disability in newly diagnosed primary open angle glaucoma (POAG) patients in a tertiary hospital in Nigeria.

PubMed

Awoyesuku, E A; Ejimadu, C S

2012-01-01

Glaucoma remains the second leading cause of blindness worldwide and the highes cause of irreversible blindness worldwide. In N Glaucoma accounts for 16% of blindness and primary open angle glaucoma is the most prevalent clinical type. The aim of this study is to assess the visual disability resulting from glaucoma in newly diagnosed POAG patients in University of Port Harcourt Teaching Hospital. This is a retrospective study of newly diagnosed glaucoma patients referred from the general ophthalmology clinic to the glaucoma clinic over a 12 month period (January-December 2010). All patients had a glaucoma workup includin Snellen distant visual acuity, slit lamp examination, Goldman applanation tonometry, gonioscopy, dilated fundoscopy with +78 diopter lens as well as perimetry. All examinations were carried out by both authors. Patients with other co-morbidities such as cataract and retinal/macular pathologies were excluded from the study. A total of 98 patients were reviewed. The were 34 males and 27 females, giving a male to female ratio of 1.3:1. The average age was 54.2 years and most patients (>80%) were in the 40-59 year age group. Of the 98 patients reviewed, 62.2% had POAG. 30 patients were-blind by distant visual acuity criteria while 45 patients were blind by central visual field criteria. POAG is the most prevalent clinical subtype of glaucoma in Nigeria and sub-Saharan Africa Paucity of symptoms in early stages of the disease at late presentation is a characteristic finding in our clinic environment. Our study showed that POAG in our environment is associated with marked visual disability at the time of presentation.

Microengineering of Metals and Ceramics: Part I: Design, Tooling and Injection Molding; Volume 3: Advanced Micro & Nanosystems

NASA Astrophysics Data System (ADS)

Baltes, Henry; Brand, Oliver; Fedder, Gary K.; Hierold, Christofer; Korvink, Jan G.; Tabata, Osamu; Löhe, Detlef; Haußelt, Jürgen

2005-09-01

Microstructures, electronics, nanotechnology - these vast fields of research are growing together as the size gap narrows and many different materials are combined. Current research, engineering sucesses and newly commercialized products hint at the immense innovative potentials and future applications that open up once mankind controls shape and function from the atomic level right up to the visible world without any gaps. In this volume, authors from three major competence centres for microengineering illustrate step by step the process from designing and simulating microcomponents of metallic and ceramic materials to replicating micro-scale components by injection molding.

Superintendents' Perceptions of the Effectiveness of Newly Hired Principals

ERIC Educational Resources Information Center

Lehman, Lynn E.; Boyland, Lori G.; Sriver, Shawn K.

2014-01-01

This study investigates the frequency of research-based leadership strategies utilized by newly hired school principals in the workplace. Public school superintendents in Indiana were asked to respond to two open-ended research questions. Through the use of content analysis, their comments were coded for the occurrence of effective leadership…

Does trade openness affect CO2 emissions: evidence from ten newly industrialized countries?

PubMed

Zhang, Shun; Liu, Xuyi; Bae, Junghan

2017-07-01

This paper examines whether the hypothetical environmental Kuznet curve (EKC) exists or not and investigates how trade openness affects CO 2 emissions, together with real GDP and total primary energy consumption. The study sample comprises ten newly industrialized countries (NICs-10) from 1971 to 2013. The results support the existence of hypothetical EKC and indicate that trade openness negatively and significantly affects emissions, while real GDP and energy do positive effects of emissions. Moreover, the empirical results of short-run causalities indicate feedback hypothetical linkage of real GDP and trade, unidirectional linkages from energy to emissions, and from trade to energy. The error correction terms (ECTs) reveal in the long run, feedback linkages of emissions, real GDP, and trade openness, while energy Granger causes emissions, real GDP, and trade, respectively. The study recommendations are that our policymakers should encourage and expand the trade openness in these countries, not only to restrain CO 2 emissions but also to boost their growth.

Improved Modeling of Open Waveguide Aperture Radiators for use in Conformal Antenna Arrays

NASA Astrophysics Data System (ADS)

Nelson, Gregory James

Open waveguide apertures have been used as radiating elements in conformal arrays. Individual radiating element model patterns are used in constructing overall array models. The existing models for these aperture radiating elements may not accurately predict the array pattern for TEM waves which are not on boresight for each radiating element. In particular, surrounding structures can affect the far field patterns of these apertures, which ultimately affects the overall array pattern. New models of open waveguide apertures are developed here with the goal of accounting for the surrounding structure effects on the aperture far field patterns such that the new models make accurate pattern predictions. These aperture patterns (both E plane and H plane) are measured in an anechoic chamber and the manner in which they deviate from existing model patterns are studied. Using these measurements as a basis, existing models for both E and H planes are updated with new factors and terms which allow the prediction of far field open waveguide aperture patterns with improved accuracy. These new and improved individual radiator models are then used to predict overall conformal array patterns. Arrays of open waveguide apertures are constructed and measured in a similar fashion to the individual aperture measurements. These measured array patterns are compared with the newly modeled array patterns to verify the improved accuracy of the new models as compared with the performance of existing models in making array far field pattern predictions. The array pattern lobe characteristics are then studied for predicting fully circularly conformal arrays of varying radii. The lobe metrics that are tracked are angular location and magnitude as the radii of the conformal arrays are varied. A constructed, measured array that is close to conforming to a circular surface is compared with a fully circularly conformal modeled array pattern prediction, with the predicted lobe angular locations and magnitudes tracked, plotted and tabulated. The close match between the patterns of the measured array and the modeled circularly conformal array verifies the validity of the modeled circularly conformal array pattern predictions.

QUANTUM ESPRESSO: a modular and open-source software project for quantum simulations of materials.

PubMed

Giannozzi, Paolo; Baroni, Stefano; Bonini, Nicola; Calandra, Matteo; Car, Roberto; Cavazzoni, Carlo; Ceresoli, Davide; Chiarotti, Guido L; Cococcioni, Matteo; Dabo, Ismaila; Dal Corso, Andrea; de Gironcoli, Stefano; Fabris, Stefano; Fratesi, Guido; Gebauer, Ralph; Gerstmann, Uwe; Gougoussis, Christos; Kokalj, Anton; Lazzeri, Michele; Martin-Samos, Layla; Marzari, Nicola; Mauri, Francesco; Mazzarello, Riccardo; Paolini, Stefano; Pasquarello, Alfredo; Paulatto, Lorenzo; Sbraccia, Carlo; Scandolo, Sandro; Sclauzero, Gabriele; Seitsonen, Ari P; Smogunov, Alexander; Umari, Paolo; Wentzcovitch, Renata M

2009-09-30

QUANTUM ESPRESSO is an integrated suite of computer codes for electronic-structure calculations and materials modeling, based on density-functional theory, plane waves, and pseudopotentials (norm-conserving, ultrasoft, and projector-augmented wave). The acronym ESPRESSO stands for opEn Source Package for Research in Electronic Structure, Simulation, and Optimization. It is freely available to researchers around the world under the terms of the GNU General Public License. QUANTUM ESPRESSO builds upon newly-restructured electronic-structure codes that have been developed and tested by some of the original authors of novel electronic-structure algorithms and applied in the last twenty years by some of the leading materials modeling groups worldwide. Innovation and efficiency are still its main focus, with special attention paid to massively parallel architectures, and a great effort being devoted to user friendliness. QUANTUM ESPRESSO is evolving towards a distribution of independent and interoperable codes in the spirit of an open-source project, where researchers active in the field of electronic-structure calculations are encouraged to participate in the project by contributing their own codes or by implementing their own ideas into existing codes.

Sequence dependency of canonical base pair opening in the DNA double helix

PubMed Central

Villa, Alessandra

2017-01-01

The flipping-out of a DNA base from the double helical structure is a key step of many cellular processes, such as DNA replication, modification and repair. Base pair opening is the first step of base flipping and the exact mechanism is still not well understood. We investigate sequence effects on base pair opening using extensive classical molecular dynamics simulations targeting the opening of 11 different canonical base pairs in two DNA sequences. Two popular biomolecular force fields are applied. To enhance sampling and calculate free energies, we bias the simulation along a simple distance coordinate using a newly developed adaptive sampling algorithm. The simulation is guided back and forth along the coordinate, allowing for multiple opening pathways. We compare the calculated free energies with those from an NMR study and check assumptions of the model used for interpreting the NMR data. Our results further show that the neighboring sequence is an important factor for the opening free energy, but also indicates that other sequence effects may play a role. All base pairs are observed to have a propensity for opening toward the major groove. The preferred opening base is cytosine for GC base pairs, while for AT there is sequence dependent competition between the two bases. For AT opening, we identify two non-canonical base pair interactions contributing to a local minimum in the free energy profile. For both AT and CG we observe long-lived interactions with water and with sodium ions at specific sites on the open base pair. PMID:28369121

HTV4 Hatch opening

NASA Image and Video Library

2013-08-09

ISS036-E-030213 (9 Aug. 2013) --- European Space Agency astronaut Luca Parmitano, Expedition 36 flight engineer, prepares to open the hatch to the newly attached Japanese "Kounotori" H2 Transfer Vehicle-4 (HTV-4) docked to the International Space Station's Harmony node.

Refugial forests of the southern Appalachians: photosynthesis and survival in current-year Abies fraseri seedlings.

PubMed

Johnson, Daniel M; Smith, William K

2005-11-01

Fraser fir (Abies fraseri (Pursh) Poiret) is an endemic, high-elevation conifer confined to six relict mountaintop communities in the southern Appalachian Mountains, USA. High adult mortality has occurred over the past 50 years, possibly the result of an introduced insect (Adelges piceae Ratzeburg), air pollution, or both. Knowledge of the mechanisms of and limitations to seedling establishment may allow reestablisment and perpetuation of this unique community type, notwithstanding global climate change. We monitored seedling emergence and mortality in relation to photosynthetic performance and water relations in microsites differing in canopy openness (sunlight exposure) over the summer of 2004. Abundance of cotyledonous seedlings in early summer was 2.3 times greater (849 versus 366 seedlings m(-2)) in microsites with lower sky exposure (greater canopy closure) than in microsites with greater sky exposure (greater canopy openness). In contrast, late-season abundance and survival were greater in areas beneath more open canopies than in areas beneath less open canopies (3.3 times and 11.7 times greater, respectively). However, newly emerged seedling survival in a completely open site (no overhead canopy) was zero, despite an initial density of 124 seedlings m(-2). Seedling water status was similar in open- and closed-canopy sites (-0.52 and -0.74 MPa, respectively). Photosynthetic carbon gain was higher in newly emerged seedlings at open canopy than at closed canopy sites, especially during early morning. Based on photosynthetic light response curves and measured sunlight regimes, seedlings in open canopy sites were estimated to assimilate 3.3-4.5 times more carbon than seedlings at closed sites. Reductions in carbon gain of closed-site seedlings, primarily a result of limited sunlight, corresponded to substantial increases in seedling mortality (98 versus 79% in open canopy sites). Thus, sunlight exposure, which reflects overstory canopy structure, appears to be an important factor influencing newly emerged seedling survival and distribution.

An Evolving Trio of Hybrid Stars: C 111

NASA Technical Reports Server (NTRS)

Oliversen, Ronald (Technical Monitor); Dupree, Andrea K.

2004-01-01

Our goal is to understand the behavior of the outer atmosphere in this intermediate stage to create a comprehensive picture of atmospheric evolution. In the hybrid phase, the large-scale magnetic dynamo activity decays and hydrodynamic processes assume importance. Some hot plasma is still confined close to the star by magnetic loops, yet the confining field is breaking open, the atmosphere can escape through these open field lines, and the diffuse corona may be warm. There may well be a more extended and variable transition process. It remains for FUSE to identify the controlling parameters of the hybrid stars. It shows the positions of our 3 targets in the color-magnitude diagram where it is seen that they are at the extreme end of the hybrid region. Originally we had been awarded the hybrid star Iota Aur, but due to newly imposed pointing constraints of FUSE, that target was not accessible. And so we substituted Iota Dra, a giant of mass similar to our other targets but less evolved. In addition, Iota Dra was recently found to harbor a sub-stellar objects, possibly a planet, and so it could reveal the stellar environment of the planet. This substitution was accepted.

Microbial control of Agrilus planipennis (Coleoptera: Buprestidae) with Beauveria bassiana strain GHA: field applications

Treesearch

Houping Liu; Leah S. Bauer

2008-01-01

The effects of Beauveria bassiana strain GHA, applied as BotaniGard ES, on newly colonised and well-established populations of emerald ash borer, Agrilus planipennis (Coleoptera: Buprestidae) were evaluated in the field using foliar and trunk sprays in Michigan in 2004-2005. Results from field trials at a newly colonised white ash...

How the IMF By induces a By-component on closed field lines during northward IMF Bz

NASA Astrophysics Data System (ADS)

Tenfjord, Paul; Østgaard, Nikolai; Strangeway, Robert J.; Reistad, Jone; Magnus Laundal, Karl; Haaland, Stein; Hesse, Michael; Snekvik, Kristian; Milan, Stephen E.

2017-04-01

We describe how the IMF By-component induces a local By-component on closed field lines during northward IMF Bz. The mechanism is the result of high-latitude reconnection on the dayside when IMF By is non-zero. We describe the dynamical process, in which tension on newly reconnected field lines redistribute the open flux asymmetrically between the two hemispheres, which leads to asymmetric energy flow into the lobes. The resulting shear flows change the magnetic field, thereby inducing a By-component on closed field lines. We use a global magnetohydrodynamics model to illustrate the mechanism. The magnetosphere imposes asymmetric forces on the ionosphere, and the effects on the ionospheric flows are characterized by a departure from a symmetric two-cell configuration to the growth of one of the lobe cells, while the other will contract. We also present the associated timescales of the local By-component to a change in the IMF By, by both theoretical arguments and by a superposed epoch analysis between magnetic field measurements from GOES and a list of IMF By reversals. We find that the magnetosphere responds within 10 minutes and reconfigures within 40 minutes.

45 CFR 159.120 - Data submission for the individual and small group markets.

Code of Federal Regulations, 2011 CFR

2011-10-01

... submit pricing and benefit data for portal plans associated with products that are newly open or newly... 45 Public Welfare 1 2011-10-01 2011-10-01 false Data submission for the individual and small group... RELATING TO HEALTH CARE ACCESS HEALTH CARE REFORM INSURANCE WEB PORTAL § 159.120 Data submission for the...

45 CFR 159.120 - Data submission for the individual and small group markets.

Code of Federal Regulations, 2010 CFR

2010-10-01

... submit pricing and benefit data for portal plans associated with products that are newly open or newly... 45 Public Welfare 1 2010-10-01 2010-10-01 false Data submission for the individual and small group... RELATING TO HEALTH CARE ACCESS HEALTH CARE REFORM INSURANCE WEB PORTAL § 159.120 Data submission for the...

Estrellas variables reconocidas en el campo del cúmulo abierto NGC 6250

NASA Astrophysics Data System (ADS)

Oviedo, C. G.; Palma, T.; Chavero, C.; Dékány, I.; Clariá, J. J.; Minniti, D.

2017-10-01

We present preliminary results obtained from a search of variable stars in the field of the moderately young open cluster NGC6250. The present study is based on the analysis of photometric near-infrared data in the and bands obtained with the 4.1m VISTA telescope of the VVV (Vista Variables in the Vía Láctea) Survey. Based on the obtained light curves, we performed a first classification of the newly detected variable stars. We also present the color-magnitude diagram of NGC6250, which is projected towards the galactic center direction, and we examined the possible physical association of the new variables discovered to NGC6250.

Switch-on Shock and Nonlinear Kink Alfvén Waves in Solar Polar Jets

NASA Astrophysics Data System (ADS)

DeVore, C. Richard; Karpen, Judith T.; Antiochos, Spiro K.; Uritsky, Vadim

2016-05-01

It is widely accepted that solar polar jets are produced by fast magnetic reconnection in the low corona, whether driven directly by flux emergence from below or indirectly by instability onset above the photosphere. In either scenario, twisted flux on closed magnetic field lines reconnects with untwisted flux on nearby open field lines. Part of the twist is inherited by the newly reconnected open flux, which rapidly relaxes due to magnetic tension forces that transmit the twist impulsively into the outer corona and heliosphere. We propose that this transfer of twist launches switch-on MHD shock waves, which propagate parallel to the ambient coronal magnetic field ahead of the shock and convect a perpendicular component of magnetic field behind the shock. In the frame moving with the shock front, the post-shock flow is precisely Alfvénic in all three directions, whereas the pre-shock flow is super-Alfvénic along the ambient magnetic field, yielding a density enhancement at the shock front. Nonlinear kink Alfvén waves are exact solutions of the time-dependent MHD equations in the post-shock region when the ambient corona is uniform and the magnetic field is straight. We have performed and analyzed 3D Cartesian and spherical simulations of polar jets driven by instability onset in the corona. The results of both simulations are consistent with the generation of MHD switch-on shocks trailed predominantly by incompressible kink Alfvén waves. It is noteworthy that the kink waves are irrotational, in sharp contrast to the vorticity-bearing torsional waves reported from previous numerical studies. We will discuss the implications of the results for understanding solar polar jets and predicting their heliospheric signatures. Our research was supported by NASA’s LWS TR&T and H-SR programs.

[Dry eye syndrome in patients with primary open-angle glaucoma].

PubMed

Boyko, E V; Simakova, I L; Yakushev, D Yu; Ignat'ev, S A; Alekseev, I B; Mel'nikova, N V; Alyab'ev, M V; Mal'tsev, D S

2015-01-01

to determine the frequency and severity of dry eye syndrome (DES) in primary open-angle glaucoma (POAG) patients that are newly diagnosed or already receiving beta blocker instillation therapy. A total of 127 patients (190 eyes) with POAG were divided into two groups. Group 1 included 55 newly diagnosed patients (88 eyes), group 2-72 POAG patients (102 eyes) instilling timolol 0.5% twice daily into the affected eye. The control group included 20 patients (40 eyes) aged 60-88 years (73.6 ± 9.2 years on average) with early age-related cataract. DES was found in 69 POAG patients (79%) who was just starting their topical hypotensive therapy and 85 of those (84%) under treatment (p = 0.39). One should take into account when prescribing ocular hypotensive therapy that newly diagnosed POAG patients usually already suffer from a dry eye. The use of topical beta blockers that contain preservatives exacerbates dry eye signs and symptoms in these patients.

Teachers' and School Counselors' Perceptions of Their Cultural Competence in Working with Newly Arrived Latino Immigrant Students: A Mixed Methods Research Study

ERIC Educational Resources Information Center

Guardiola Castillo, Irma V.

2014-01-01

The purpose of this study was to explore teachers' and school counselors' perceptions of their cultural competence in working with newly arrived Latino immigrant students by using a mixed instrument with closed-ended and open-ended items. Multicultural Counseling Competencies (MCC) served as the theoretical framework for this study (Sue,…

Revisiting the emissions-energy-trade nexus: evidence from the newly industrializing countries.

PubMed

Ahmed, Khalid; Shahbaz, Muhammad; Kyophilavong, Phouphet

2016-04-01

This paper applies Pedroni's panel cointegration approach to explore the causal relationship between trade openness, carbon dioxide emissions, energy consumption, and economic growth for the panel of newly industrialized economies (i.e., Brazil, India, China, and South Africa) over the period of 1970-2013. Our panel cointegration estimation results found majority of the variables cointegrated and confirm the long-run association among the variables. The Granger causality test indicates bidirectional causality between carbon dioxide emissions and energy consumption. A unidirectional causality is found running from trade openness to carbon dioxide emission and energy consumption and economic growth to carbon dioxide emissions. The results of causality analysis suggest that the trade liberalization in newly industrialized economies induces higher energy consumption and carbon dioxide emissions. Furthermore, the causality results are checked using an innovative accounting approach which includes forecast-error variance decomposition test and impulse response function. The long-run coefficients are estimated using fully modified ordinary least square (FMOLS) method, and results conclude that the trade openness and economic growth reduce carbon dioxide emissions in the long run. The results of FMOLS test sound the existence of environmental Kuznets curve hypothesis. It means that trade liberalization induces carbon dioxide emission with increased national output, but it offsets that impact in the long run with reduced level of carbon dioxide emissions.

Exotic ferromagnetism in the two-dimensional quantum material C3N

NASA Astrophysics Data System (ADS)

Huang, Wen-Cheng; Li, Wei; Liu, Xiaosong

2018-04-01

The search for and study of exotic quantum states in novel low-dimensional quantum materials have triggered extensive research in recent years. Here, we systematically study the electronic and magnetic structures in the newly discovered two-dimensional quantum material C3N within the framework of density functional theory. The calculations demonstrate that C3N is an indirect-band semiconductor with an energy gap of 0.38 eV, which is in good agreement with experimental observations. Interestingly, we find van Hove singularities located at energies near the Fermi level, which is half that of graphene. Thus, the Fermi energy easily approaches that of the singularities, driving the system to ferromagnetism, under charge carrier injection, such as electric field gating or hydrogen doping. These findings not only demonstrate that the emergence of magnetism stems from the itinerant electron mechanism rather than the effects of local magnetic impurities, but also open a new avenue to designing field-effect transistor devices for possible realization of an insulator-ferromagnet transition by tuning an external electric field.

A perspective of Genes and Environment for the development of environmental mutagen research in Asia.

PubMed

Yagi, Takashi

2017-01-01

Two years have passed since the Japanese Environmental Society (JEMS) made the official journal Genes and Environment (G&E) open access. Current subjects on environmental mutagen research to further advance this field are described herein, and the roles of JEMS and G&E are discussed. Various important subjects are being investigated in current research fields such as severe environmental pollution in Asian countries; the identification of new hazardous substances and elucidation of mutation mechanisms using newly developed techniques; the development of new genotoxicity assays including in silico predictions using information technology and artificial intelligence as well as bioassays. International exchange by scientists is important for advancing these research fields through international conferences such as the 12th International Conference and 5th Asian Congress on Environmental Mutagens and the 7th International Workshop on Genotoxicity Testing that will be held in 2017. G&E provides a common platform for high quality environmental mutagen research, contributes to the dissemination of Asian environmental mutagen research, and potentiates the level of research being conducted.

HOW CAN NEWLY BORN RAPIDLY ROTATING NEUTRON STARS BECOME MAGNETARS?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheng, Quan; Yu, Yun-Wei, E-mail: yuyw@mail.ccnu.edu.cn

2014-05-10

In a newly born (high-temperature and Keplerian rotating) neutron star, r-mode instability can lead to stellar differential rotation, which winds the seed poloidal magnetic field (∼10{sup 11} G) to generate an ultra-high (∼10{sup 17} G) toroidal field component. Subsequently, by succumbing to the Tayler instability, the toroidal field could be partially transformed into a new poloidal field. Through such dynamo processes, the newly born neutron star with sufficiently rapid rotation could become a magnetar on a timescale of ∼10{sup 2} {sup –} {sup 3} s, with a surface dipolar magnetic field of ∼10{sup 15} G. Accompanying the field amplification, the star could spinmore » down to a period of ∼5 ms through gravitational wave radiation due to the r-mode instability and, in particular, the non-axisymmetric stellar deformation caused by the toroidal field. This scenario provides a possible explanation for why the remnant neutron stars formed in gamma-ray bursts and superluminous supernovae could be millisecond magnetars.« less

The Human Exposure Model (HEM): A Tool to Support Rapid ...

EPA Pesticide Factsheets

The US EPA is developing an open and publically available software program called the Human Exposure Model (HEM) to provide near-field exposure information for Life Cycle Impact Assessments (LCIAs). Historically, LCIAs have often omitted impacts from near-field sources of exposure. The use of consumer products often results in near-field exposures (exposures that occur directly from the use of a product) that are larger than environmentally mediated exposures (i.e. far-field sources)1,2. Failure to consider near-field exposures could result in biases in LCIA-based determinations of the relative sustainability of consumer products. HEM is designed to provide this information.Characterizing near-field sources of chemical exposures present a challenge to LCIA practitioners. Unlike far-field sources, where multimedia mass balance models have been used to determine human exposure, near-field sources require product-specific models of human exposure and considerable information on product use and product composition. Such information is difficult and time-consuming to gather and curate. The HEM software will characterize the distribution of doses and product intake fractions2 across populations of product users and bystanders, allowing for differentiation by various demographic characteristics. The tool incorporates a newly developed database of the composition of more than 17,000 products, data on physical and chemical properties for more than 2,000 chemicals, and mo

Harvesting energy from the natural vibration of human walking.

PubMed

Yang, Weiqing; Chen, Jun; Zhu, Guang; Yang, Jin; Bai, Peng; Su, Yuanjie; Jing, Qingsheng; Cao, Xia; Wang, Zhong Lin

2013-12-23

The triboelectric nanogenerator (TENG), a unique technology for harvesting ambient mechanical energy based on the triboelectric effect, has been proven to be a cost-effective, simple, and robust approach for self-powered systems. However, a general challenge is that the output current is usually low. Here, we demonstrated a rationally designed TENG with integrated rhombic gridding, which greatly improved the total current output owing to the structurally multiplied unit cells connected in parallel. With the hybridization of both the contact-separation mode and sliding electrification mode among nanowire arrays and nanopores fabricated onto the surfaces of two contact plates, the newly designed TENG produces an open-circuit voltage up to 428 V, and a short-circuit current of 1.395 mA with the peak power density of 30.7 W/m(2). Relying on the TENG, a self-powered backpack was developed with a vibration-to-electric energy conversion efficiency up to 10.62(±1.19) %. And it was also demonstrated as a direct power source for instantaneously lighting 40 commercial light-emitting diodes by harvesting the vibration energy from natural human walking. The newly designed TENG can be a mobile power source for field engineers, explorers, and disaster-relief workers.

Retention of Text Material under Cued and Uncued Recall and Open and Closed Book Conditions

ERIC Educational Resources Information Center

Nevid, Jeffrey S.; Pyun, Yea Seul; Cheney, Brianna

2016-01-01

Evidence supports the benefits of effortful processing in strengthening retention of newly learned material. The present study compared two forms of effortful processing, uncued (free) recall and cued recall, under both open and closed book conditions, on both immediate and delayed (one-week) test performance. Participants read a section of a…

Development of methods for the field evaluation of Oobius agrili (Hymenoptera: Encyrtidae) in North America, a newly introduced egg parasitoid of the emerald ash borer (Coleoptera: Buprestidae)

Treesearch

Jian J. Duan; Leah S. Bauer; Michael D. Ulyshen; Juli R. Gould; Roy Van Driesche

2011-01-01

A field study was conducted in forested plots near Lansing, Michigan in 2008 and 2009 to evaluate the newly introduced egg parasitoid Oobius agrili Zhang and Huang (Hymenoptera: Encyrtidae) for control of the invasive emerald ash borer (EAB), Agrilus planipennis Fairmaire (Coleoptera: Buprestidae). To measure parasitism by

Field-Aligned Currents in Saturn's Nightside Magnetosphere: Subcorotation and Planetary Period Oscillation Components During Northern Spring

NASA Astrophysics Data System (ADS)

Bradley, T. J.; Cowley, S. W. H.; Provan, G.; Hunt, G. J.; Bunce, E. J.; Wharton, S. J.; Alexeev, I. I.; Belenkaya, E. S.; Kalegaev, V. V.; Dougherty, M. K.

2018-05-01

We newly analyze Cassini magnetic field data from the 2012/2013 Saturn northern spring interval of highly inclined orbits and compare them with similar data from late southern summer in 2008, thus providing unique information on the seasonality of the currents that couple momentum between Saturn's ionosphere and magnetosphere. Inferred meridional ionospheric currents in both cases consist of a steady component related to plasma subcorotation, together with the rotating current systems of the northern and southern planetary period oscillations (PPOs). Subcorotation currents during the two intervals show opposite north-south polar region asymmetries, with strong equatorward currents flowing in the summer hemispheres but only weak currents flowing to within a few degrees of the open-closed boundary (OCB) in the winter hemispheres, inferred due to weak polar ionospheric conductivities. Currents peak at 1 MA rad-1 in both hemispheres just equatorward of the open-closed boundary, associated with total downward polar currents 6 MA, then fall across the narrow auroral upward current region to small values at subauroral latitudes. PPO-related currents have a similar form in both summer and winter with principal upward and downward field-aligned currents peaking at 1.25 MA rad-1 being essentially collocated with the auroral upward current and approximately equal in strength. Though northern and southern PPO currents were approximately equal during both intervals, the currents in both hemispheres were dual modulated by both systems during 2012/2013, with approximately half the main current closing in the opposite ionosphere and half cross field in the magnetosphere, while only the northern hemisphere currents were similarly dual modulated in 2008.

A dansyl-rhodamine chemosensor for Fe(III) based on off-on FRET.

PubMed

Piao, Jingyu; Lv, Jia; Zhou, Xin; Zhao, Tong; Wu, Xue

2014-07-15

A novel fluorescent chemosensor bearing a rhodamine and a dansyl moiety was developed for highly selective detection of Fe(3+) based on fluorescence resonance energy transfer (FRET) mechanism. Binding of Fe(3+) to the chemosensor induced spirolactam ring opening in the rhodamine moiety and subsequent off-on FRET from the dansyl energy donor to the rhodamine energy acceptor due to the spectral overlap between the emission of the dansyl moiety and the absorption of the ring opened rhodamine moiety. Job's plot analysis indicated a 1:1 binding stoichiometry between the chemosensor and Fe(3+). The association constant was estimated to be 2.72×10(3) M(-1) according to the Benesi-Hildebrand method. With the feature of easy synthesis, simple structural skeleton and excellent sensing ability, the newly synthesized chemosensor provided the potential for applying as a highly selective fluorescent probe in complex samples containing various competitive metal ions and developing other metal ion chemosensors to fulfill various needs of biological and environmental field. Copyright © 2014 Elsevier B.V. All rights reserved.

Publishing Ethics and Predatory Practices: A Dilemma for All Stakeholders of Science Communication.

PubMed

Gasparyan, Armen Yuri; Yessirkepov, Marlen; Diyanova, Svetlana N; Kitas, George D

2015-08-01

Publishing scholarly articles in traditional and newly-launched journals is a responsible task, requiring diligence from authors, reviewers, editors, and publishers. The current generation of scientific authors has ample opportunities for publicizing their research. However, they have to selectively target journals and publish in compliance with the established norms of publishing ethics. Over the past few years, numerous illegitimate or predatory journals have emerged in most fields of science. By exploiting gold Open Access publishing, these journals paved the way for low-quality articles that threatened to change the landscape of evidence-based science. Authors, reviewers, editors, established publishers, and learned associations should be informed about predatory publishing practices and contribute to the trustworthiness of scholarly publications. In line with this, there have been several attempts to distinguish legitimate and illegitimate journals by blacklisting unethical journals (the Jeffrey Beall's list), issuing a statement on transparency and best publishing practices (the Open Access Scholarly Publishers Association's and other global organizations' draft document), and tightening the indexing criteria by the Directory of Open Access Journals. None of these measures alone turned to be sufficient. All stakeholders of science communication should be aware of multiple facets of unethical practices and publish well-checked and evidence-based articles.

Publishing Ethics and Predatory Practices: A Dilemma for All Stakeholders of Science Communication

PubMed Central

Yessirkepov, Marlen; Diyanova, Svetlana N.; Kitas, George D.

2015-01-01

Publishing scholarly articles in traditional and newly-launched journals is a responsible task, requiring diligence from authors, reviewers, editors, and publishers. The current generation of scientific authors has ample opportunities for publicizing their research. However, they have to selectively target journals and publish in compliance with the established norms of publishing ethics. Over the past few years, numerous illegitimate or predatory journals have emerged in most fields of science. By exploiting gold Open Access publishing, these journals paved the way for low-quality articles that threatened to change the landscape of evidence-based science. Authors, reviewers, editors, established publishers, and learned associations should be informed about predatory publishing practices and contribute to the trustworthiness of scholarly publications. In line with this, there have been several attempts to distinguish legitimate and illegitimate journals by blacklisting unethical journals (the Jeffrey Beall's list), issuing a statement on transparency and best publishing practices (the Open Access Scholarly Publishers Association's and other global organizations' draft document), and tightening the indexing criteria by the Directory of Open Access Journals. None of these measures alone turned to be sufficient. All stakeholders of science communication should be aware of multiple facets of unethical practices and publish well-checked and evidence-based articles. PMID:26240476

Microengineering of Metals and Ceramics: Part II: Special Replication Techniques, Automation and Properties; Volume 4: Advanced Micro & Nanosystems

NASA Astrophysics Data System (ADS)

Baltes, Henry; Brand, Oliver; Fedder, Gary K.; Hierold, Christofer; Korvink, Jan G.; Tabata, Osamu; Löhe, Detlef; Haußelt, Jürgen

2005-10-01

Microstructures, electronics, nanotechnology - these vast fields of research are growing together as the size gap narrows and many different materials are combined. Current research, engineering sucesses and newly commercialized products hint at the immense innovative potentials and future applications that open up once mankind controls shape and function from the atomic level right up to the visible world without any gaps. Continuing from the previous volume, authors from three major competence centres for microengineering here cover all aspects of specialized replication techniques and how to employ state-of-the-art technologies for testing and characterizing micro-scale components, and illustrate quality control aspects and strategies for automation of production procedures in view of future industrial production and commercialisation.

A flange on electron spectromicroscope with spherical deflector analyzer--simultaneous imaging of reciprocal and real spaces.

PubMed

Grzelakowski, Krzysztof P

2013-07-01

An instrumental realization of the idea for the electron emission spectromicroscope based on the newly developed imaging energy filter called α-SDA (Spherical Deflector Analyzer) is reported. Its compact design enables the realization of the flange-on spectromicroscope concept. It is equipped with two independent energy selective imaging channels: one for real and another for reciprocal space visualization. These images can be acquired quasi-simultaneousely by means of the software based on the switching on and off potentials of the energy filter. An electron gun located inside the immersion objective lens allows a new kind of sample illumination by high energy primary electrons and thus, opens a new application field for electron spectromicroscopy under laboratory conditions. Copyright © 2013 Elsevier B.V. All rights reserved.

A search for extra-solar planetary transits in the field of open cluster NGC 6819

NASA Astrophysics Data System (ADS)

Street, Rachel Amanda

The technique of searching for extra-solar planetary transits is investigated. This technique, which relies on detecting the brief, shallow eclipses caused by planets passing across the line of sight to the primary star, requires high-precision time-series photometry of large numbers of stars in order to detect these statistically rare events. Observations of 18000 stars in the field including the intermediate-age open cluster NGC 6819 are presented. This target field constrasts with the stellar environment surveyed by the radial velocity technique, which concentrates on the Solar neighbourhood. I present the data-reduction techniques used to obtain high-precision photometry in a semi-automated fashion for tens of thousands of stars at a time, together with an algorithm designed to search the resulting lightcurves for the transit signatures of hot Jupiter type planets. I describe simulations designed to test the detection efficiency of this algorithm and, for comparison, predict the number of transits expected from this data, assuming that hot Jupiter planets similar to HD 209458 are as common in the field of NGC 6819 as they are in the Solar neighbourhood. While no planetary transits have yet been identified, the detection of several very low amplitude eclipses by stellar companions demonstrates the effectiveness of the method. This study also indicates that stellar activity and particularly blending are significant causes of false detections. A useful additional consequence of studying this time-series photometry is the census it provides of some of the variable stars in the field. I report on the discovery of a variety of newly-discovered variables, including Algol-type detached eclipsing binaries which are likely to consist of M-dwarf stars. Further study of these stars is strongly recommended in order to help constrain models of stellar structure at the very low mass end. I conclude with a summary of this work in the context of other efforts being made in this field and recommend promising avenues of further study.

Regulation of hTERT Expression and Function in Newly Immortalized p53(+) Human Mammary Epithelial Cell Lines

DTIC Science & Technology

2008-06-01

proteins during embryogene- sis, neurodevelopment and cancer. Part of their function is through the repression of CKIs, including p16. Some functions...protein 2 Other AUTS2 autism susceptibility candidate 2 C1orf24 chromosome 1 open reading frame 24 C20orf97 chromosome 20 open reading frame 97

Regulation of hTERT Expression and Function in Newly Immortalized p53(+) Human Mammary Epithelial Cell Lines

DTIC Science & Technology

2007-06-01

embryogene- sis, neurodevelopment and cancer. Part of their function is through the repression of CKIs, including p16. Some functions have been attributed to...AUTS2 autism susceptibility candidate 2 C1orf24 chromosome 1 open reading frame 24 C20orf97 chromosome 20 open reading frame 97 DKFZP566B183

Detonation Diffraction in a Multi-Step Channel

DTIC Science & Technology

2010-12-01

openings. This allowed the detonation wave diffraction transmission limits to be determined for hydrogen/air mixtures and to better understand...imaging systems to provide shock wave detail and velocity information. The images were observed through a newly designed explosive proof optical section...stepped openings. This allowed the detonation wave diffraction transmission limits to be determined for hydrogen/air mixtures and to better

Newly velocity field of Sulawesi Island from GPS observation

NASA Astrophysics Data System (ADS)

Sarsito, D. A.; Susilo, Simons, W. J. F.; Abidin, H. Z.; Sapiie, B.; Triyoso, W.; Andreas, H.

2017-07-01

Sulawesi microplate Island is located at famous triple junction area of the Eurasian, India-Australian, and Philippine Sea plates. Under the influence of the northward moving Australian plate and the westward motion of the Philippine plate, the island at Eastern part of Indonesia is collide and with the Eurasian plate and Sunda Block. Those recent microplate tectonic motions can be quantitatively determine by GNSS-GPS measurement. We use combine GNSS-GPS observation types (campaign type and continuous type) from 1997 to 2015 to derive newly velocity field of the area. Several strategies are applied and tested to get the optimum result, and finally we choose regional strategy to reduce error propagation contribution from global multi baseline processing using GAMIT/GLOBK 10.5. Velocity field are analyzed in global reference frame ITRF 2008 and local reference frame by fixing with respect alternatively to Eurasian plate - Sunda block, India-Australian plate and Philippine Sea plates. Newly results show dense distribution of velocity field. This information is useful for tectonic deformation studying in geospatial era.

Investigation of internal magnetic structures and comparison with two-fluid equilibrium configurations in the multi-pulsing CHI on HIST

NASA Astrophysics Data System (ADS)

Nakayama, T.; Hanao, T.; Hirono, H.; Hyobu, T.; Ito, K.; Matsumoto, K.; Kikuchi, Y.; Fukumoto, N.; Nagata, M.; Kanki, T.

2012-10-01

Spherical torus (ST) plasmas have been successfully maintained by Muti-pulsing Coaxial Helicity Injection (M-CHI) on HIST. This research object is to clarify relations between plasma characteristics and magnetic flux amplifications, and to compare magnetic field structures measured in the plasma interior to a flowing equilibrium calculation. Two-dimensional magnetic probe array has been newly introduced nearby the gun muzzle. The initial result shows that the diverter configuration with a single X-point can be formed after a bubble burst process of the plasma. The closed magnetic flux is surrounded by the open magnetic field lines intersecting with the gun electrodes. To evaluate the sustained configurations, we use the two-fluid equilibrium code containing generalized Bernoulli and Grad-Shafranov equations which was developed by L.C. Steinhauer. The radial profiles of plasma flow, density and magnetic fields measured on the midplane of the FC are consistent to the calculation. We also found that the poloidal shear flow generation is attributed to ExB drift and ion diamagnetic drift. In addition, we will study temporal behaviors of impurity lines such as OV and OVI during the flux amplification by VUV spectroscopic measurements.

Causal mechanisms of seismo-EM phenomena during the 1965-1967 Matsushiro earthquake swarm.

PubMed

Enomoto, Yuji; Yamabe, Tsuneaki; Okumura, Nobuo

2017-03-21

The 1965-1967 Matsushiro earthquake swarm in central Japan exhibited two unique characteristics. The first was a hydro-mechanical crust rupture resulting from degassing, volume expansion of CO 2 /water, and a crack opening within the critically stressed crust under a strike-slip stress. The other was, despite the lower total seismic energy, the occurrence of complexed seismo-electromagnetic (seismo-EM) phenomena of the geomagnetic intensity increase, unusual earthquake lights (EQLs) and atmospheric electric field (AEF) variations. Although the basic rupture process of this swarm of earthquakes is reasonably understood in terms of hydro-mechanical crust rupture, the associated seismo-EM processes remain largely unexplained. Here, we describe a series of seismo-EM mechanisms involved in the hydro-mechanical rupture process, as observed by coupling the electric interaction of rock rupture with CO 2 gas and the dielectric-barrier discharge of the modelled fields in laboratory experiments. We found that CO 2 gases passing through the newly created fracture surface of the rock were electrified to generate pressure-impressed current/electric dipoles, which could induce a magnetic field following Biot-Savart's law, decrease the atmospheric electric field and generate dielectric-barrier discharge lightning affected by the coupling effect between the seismic and meteorological activities.

Causal mechanisms of seismo-EM phenomena during the 1965–1967 Matsushiro earthquake swarm

PubMed Central

Enomoto, Yuji; Yamabe, Tsuneaki; Okumura, Nobuo

2017-01-01

The 1965–1967 Matsushiro earthquake swarm in central Japan exhibited two unique characteristics. The first was a hydro-mechanical crust rupture resulting from degassing, volume expansion of CO2/water, and a crack opening within the critically stressed crust under a strike-slip stress. The other was, despite the lower total seismic energy, the occurrence of complexed seismo-electromagnetic (seismo-EM) phenomena of the geomagnetic intensity increase, unusual earthquake lights (EQLs) and atmospheric electric field (AEF) variations. Although the basic rupture process of this swarm of earthquakes is reasonably understood in terms of hydro-mechanical crust rupture, the associated seismo-EM processes remain largely unexplained. Here, we describe a series of seismo-EM mechanisms involved in the hydro-mechanical rupture process, as observed by coupling the electric interaction of rock rupture with CO2 gas and the dielectric-barrier discharge of the modelled fields in laboratory experiments. We found that CO2 gases passing through the newly created fracture surface of the rock were electrified to generate pressure-impressed current/electric dipoles, which could induce a magnetic field following Biot-Savart’s law, decrease the atmospheric electric field and generate dielectric-barrier discharge lightning affected by the coupling effect between the seismic and meteorological activities. PMID:28322263

Causal mechanisms of seismo-EM phenomena during the 1965-1967 Matsushiro earthquake swarm

NASA Astrophysics Data System (ADS)

Enomoto, Yuji; Yamabe, Tsuneaki; Okumura, Nobuo

2017-03-01

The 1965-1967 Matsushiro earthquake swarm in central Japan exhibited two unique characteristics. The first was a hydro-mechanical crust rupture resulting from degassing, volume expansion of CO2/water, and a crack opening within the critically stressed crust under a strike-slip stress. The other was, despite the lower total seismic energy, the occurrence of complexed seismo-electromagnetic (seismo-EM) phenomena of the geomagnetic intensity increase, unusual earthquake lights (EQLs) and atmospheric electric field (AEF) variations. Although the basic rupture process of this swarm of earthquakes is reasonably understood in terms of hydro-mechanical crust rupture, the associated seismo-EM processes remain largely unexplained. Here, we describe a series of seismo-EM mechanisms involved in the hydro-mechanical rupture process, as observed by coupling the electric interaction of rock rupture with CO2 gas and the dielectric-barrier discharge of the modelled fields in laboratory experiments. We found that CO2 gases passing through the newly created fracture surface of the rock were electrified to generate pressure-impressed current/electric dipoles, which could induce a magnetic field following Biot-Savart’s law, decrease the atmospheric electric field and generate dielectric-barrier discharge lightning affected by the coupling effect between the seismic and meteorological activities.

Long-period tilt-induced accelerations associated with hydraulic fracturing

NASA Astrophysics Data System (ADS)

Milkereit, Claus; Dahm, Torsten; Cesca, Simone; Lopez, Jose; Nooshiri, Nima; Zang, Arno

2017-04-01

In 2015, several small scale hydrofracture experiments have been performed in situ from a horizontal borehole in a mine gallery in granitic rock. The hydrofracture experiments were monitored by a bundle of different near field sensors covering a broad range of frequencies (see Zang et al., Geophys. J. Int. (2017) 208, 790-813, doi: 10.1093/gji/ggw430). We installed broad band sensors in the gallery close to the fracture experiments, and observed clear long period transients on the horizontal components, with timing and polarity correlated with the opening and closing of the fractures. We interpret the broadband signals as tilt-induced excursions. The broadband signals have been measured independent whether high frequency acoustic emission have been observed or not during the individual fracture experiments. They are thus an independent measure of the success of a hydrofracture experiment and the parameter of the newly formed cracks. In this study we show that most tilt-induced long-period signals can be modeled by a rectangular crack with constant opening in an elastic full space, as first order approximation. From theoretical forward modeling, we proof that the tilt has a higher sensitivity to resolve the strike of the fracture than the displacement field. With this model, we retrieve the strike of the fractures from the tilt observed at a single sensor. The results indicate that the strike angles of the hydrofractures change systematically with the distance to the gallery wall, indicating a rotation of the principal stresses close to the free surface of the gallery. The rotation trend is similar to the one observed in previous hydrofracture experiments in mines. We compare the strength of the modeled tensile cracks, i.e. opening times crack area, with the volume of the injected fluid, and discuss the general resolving power of tilt signals for source parameter fractures. The temporal evolution of the opening and closure of the fractures is discussed.

The Health Of Patients' Eyes (HOPE) Glaucoma study. The effectiveness of a 'glaucoma personal record' for newly diagnosed glaucoma patients: study protocol for a randomised controlled trial.

PubMed

Forbes, Marina; Fairlamb, Helen; Jonker, Leon

2015-08-07

Glaucoma involves progressive optic nerve fibre loss, subsequently leading to irreversible and disabling visual field defects. In Europe, the prevalence of glaucoma is approximately 2.2 % of all people aged over 40 years; this equates to 12 million people. Glaucoma patients require regular lifelong follow-up, contributing to a large financial and resource burden for the National Health Service (NHS) in the UK. This study aims to determine whether providing newly diagnosed glaucoma patients with a personalised client-held eye health summary ('glaucoma personal record'), improves patients' knowledge of their glaucoma condition. A potential long-term benefit could be improved self-management and henceforth a slower rate of deterioration. HOPE Glaucoma is a 3-year, prospective, parallel-group, pragmatic, single-centred, randomised controlled trial. An anticipated 122 adults, newly diagnosed with glaucoma (including ocular hypertension, suspected glaucoma and/or chronic open-angle glaucoma) will be recruited from a nurse-led ophthalmology outpatient clinic at a medium-sized NHS Trust. Participants will be randomly allocated to receive standard clinical care (control arm) or standard care plus a glaucoma personal record, detailing the current state of their condition (interventional arm). Participant assessments are designed to test whether provision of a glaucoma personal record 1) improves patient knowledge of glaucoma and 2) contributes to improvements in clinical outcomes, i.e. delay of visual field loss. The primary outcome measure is better client knowledge of glaucoma at the 9-12 month follow-up visit. Secondary outcome measures include the rate of visual field loss and patient-reported outcome measures on visual function (National Eye Institute VFQ - 25) measured at baseline, 9-12 months, 24 months and 36 months. Estimating a 20 % drop-out rate, the study will have 90 % power to detect a mean two-point difference in glaucoma knowledge score between groups at 5 % significance - based on two-sided Mann-Whitney U test. If a glaucoma personal record is found to significantly improve glaucoma patients' knowledge of their condition, this intervention could potentially provide a low-cost, straightforward tool to educate and engage glaucoma patients. Subsequently, this could have the potential to increase patient self-management and therefore allow glaucoma patients to prolong their sight functionality for longer. ISRCTN41306818 , registered on 22 August 2013.

Tripolar electric field Structure in guide field magnetic reconnection

NASA Astrophysics Data System (ADS)

Fu, Song; Huang, Shiyong; Zhou, Meng; Ni, Binbin; Deng, Xiaohua

2018-03-01

It has been shown that the guide field substantially modifies the structure of the reconnection layer. For instance, the Hall magnetic and electric fields are distorted in guide field reconnection compared to reconnection without guide fields (i.e., anti-parallel reconnection). In this paper, we performed 2.5-D electromagnetic full particle simulation to study the electric field structures in magnetic reconnection under different initial guide fields (Bg). Once the amplitude of a guide field exceeds 0.3 times the asymptotic magnetic field B0, the traditional bipolar Hall electric field is clearly replaced by a tripolar electric field, which consists of a newly emerged electric field and the bipolar Hall electric field. The newly emerged electric field is a convective electric field about one ion inertial length away from the neutral sheet. It arises from the disappearance of the Hall electric field due to the substantial modification of the magnetic field and electric current by the imposed guide field. The peak magnitude of this new electric field increases linearly with the increment of guide field strength. Possible applications of these results to space observations are also discussed.

Mesoscale Magnetosphere-Ionosphere Coupling along Open Magnetic Field Lines Associated with Airglow Patches: Field-aligned Currents and Precipitation

NASA Astrophysics Data System (ADS)

Zou, Y.; Nishimura, Y.; Lyons, L. R.; Shiokawa, K.; Burchill, J. K.; Knudsen, D. J.; Buchert, S. C.; Chen, S.; Nicolls, M. J.; Ruohoniemi, J. M.; McWilliams, K. A.; Nishitani, N.

2016-12-01

Although airglow patches are traditionally regarded as high-density plasma unrelated to local field-aligned currents (FACs) and precipitation, past observations were limited to storm-time conditions. Recent non-storm time observations show patches to be associated with azimuthally narrow ionospheric fast flow channels that substantially contribute to plasma transportation across the polar cap and connect dayside and nightside explosive disturbances. We examine whether non-storm time patches are related also to localized polar cap FACs and precipitation using Swarm- and FAST-imager-radar conjunctions. In Swarm data, we commonly (66%) identify substantial magnetic perturbations indicating FAC enhancements around patches. These FACs have substantial densities (0.1-0.2 μA/m-2) and can be approximated as infinite current sheets (typically 75 km wide) orientated roughly parallel to patches. They usually exhibit a Region-1 sense, i.e. a downward FAC lying eastward of an upward FAC, and can close through Pedersen currents in the ionosphere, implying that the locally enhanced dawn-dusk electric field across the patch is imposed by processes in the magnetosphere. In FAST data, we identify localized precipitation that is enhanced within patches in comparison to weak polar rain outside patches. The precipitation consists of structured or diffuse soft electron fluxes. While the latter resembles polar rain only with higher fluxes, the former consists of discrete fluxes enhanced by 1-2 orders of magnitude from several to several hundred eV. Although the precipitation is not a major contributor to patch ionization, it implies that newly reconnected flux tubes that retain electrons of magnetosheath origin can rapidly traverse the polar cap from the dayside. Therefore non-storm time patches should be regarded as part of a localized magnetosphere-ionosphere coupling system along open magnetic field lines, and their transpolar evolution as a reflection of reconnected flux tubes traveling from the dayside to nightside magnetosphere.

Mini-CME eruptions in a flux emergence event in a coronal hole environment

NASA Astrophysics Data System (ADS)

Galsgaard, K.; Moreno-Insertis, F.

2016-10-01

Small scale jets are observed to take place at the interface between the open magnetic field in coronal holes and bipolar magnetic field concentrations. A fraction of these shows an eruptive behavior, where a combination of cold dense and hot light plasma has been observed to propagate out along the jet region, combining traditional jets with what looks like the eruption of mini-CMEs. Here we discuss a simple model scenario for the explosive energy release process that leads to a mixture of hot and cold plasma being accelerated upwards simultaneously. The model explains both the typical steady state inverted-Y jet and the subsequent mini-CME eruptions found in blowout jets. The numerical experiment consists of a buoyant unstable flux rope that emerges into an overlying slanted coronal field, thereby creating a bipolar magnetic field distribution in the photosphere with coronal loops linking the polarities. Reconnection between the emerged and preexisting magnetic systems including the launching of a classical inverted-Y jet. The experiment shows that this simple model provides for a very complicated dynamical behavior in its late phases. Five independent mini-CME eruptions follow the initial near steady-state jet phase. The first one is a direct consequence of the reconnection of the emerged magnetic flux, is mediated by the formation of a strongly sheared arcade followed by a tether-cutting reconnection process, and leads to the eruption of a twisted flux rope. The final four explosive eruptions, instead, are preceded by the formation of a twisted torus-like flux rope near the strong magnetic concentrations at the photosphere. As the tube center starts emerging an internal current sheet is formed below it. This sheet experiences a tether cutting process that provides the important upwards kick of the newly formed mini-CME structure. As the fast rising cold and dense tube interacts with the overlying magnetic field, it reconnects at different spatial locations, either through a null region or through a local strong shear region without nulls. The restructuring of the magnetic field lines generate magneto-acoustic waves that transport twist and cold plasma out along the less stressed parts of the newly reconnected field lines. The emphasis of the talk will be on the physical forces responsible for the initial flux tube rising and the effects and reasons for the following destruction of the mini-CMEs.

Cultivation of an Interdisciplinary, Research-Based Neuroscience Minor at Hope College

PubMed Central

Chase, Leah A.; Stewart, Joanne; Barney, Christopher C.

2006-01-01

Hope College is an undergraduate liberal arts college with an enrollment of approximately 3,000 students. In the spring of 2005, we began to offer an interdisciplinary neuroscience minor program that is open to all students. The objective of this program is to introduce students to the field of neuroscience, and to do so in such a way as to broaden students’ disciplinary perspectives, enhance communication and quantitative skills, and increase higher-level reasoning skills by encouraging collaboration among students who have different disciplinary backgrounds. This is a research-based program that culminates in a one-year capstone research course. Here we present the story of the program development at Hope College, including a description of our newly developed curriculum, our initial assessment data, and the lessons we have learned in developing this program. PMID:23493857

Practice and payment preferences of newly practising family physicians in British Columbia

PubMed Central

Brcic, Vanessa; McGregor, Margaret J.; Kaczorowski, Janusz; Dharamsi, Shafik; Verma, Serena

2012-01-01

Abstract Objective To examine the remuneration model preferences of newly practising family physicians. Design Mixed-methods study comprising a cross-sectional, Web-based survey, as well as qualitative content analysis of answers to open-ended questions. Setting British Columbia. Participants University of British Columbia family practice residents who graduated between 2000 and 2009. Main outcome measures Preferred remuneration models of newly practising physicians. Results The survey response rate was 31% (133 of 430). Of respondents, 71% (93 of 132) preferred non–fee-for-service practice models and 86% (110 of 132) identified the payment model as very or somewhat important in their choice of future practice. Three principal themes were identified from content analysis of respondents’ open-ended comments: frustrations with fee-for-service billing, which encompassed issues related to aggravations with “the business side of things” and was seen as impeding “the freedom to focus on medicine”; quality of patient care, which embraced the importance of a payment model that supported “comprehensive patient care” and “quality rather than quantity”; and freedom to choose, which supported the plurality of practice preferences among providers who strived to provide quality care for patients, “whatever model you happen to be working in.” Conclusion Newly practising physicians in British Columbia preferred alternatives to fee-for-service payment models, which were perceived as contributing to fewer frustrations with billing systems, improved quality of work life, and better quality of patient care. PMID:22586205

Out of the archaeologist's desk drawer: communicating archaeological data online

NASA Astrophysics Data System (ADS)

Abate, D.; David, M.

2015-08-01

During archaeological field work a huge amount of data is collected, processed and elaborated for further studies and scientific publications. However, access and communication of linked data; associated tools for interrogation, analysis and sharing are often limited at the first stage of the archaeological research, mainly due to issues related to IPR. Information is often released months if not years after the fieldwork. Nowadays great deal of archaeological data is `born digital' in the field or lab. This means databases, pictures and 3D models of finds and excavation contexts could be available for public communication and sharing. Researchers usually restrict access to their data to a small group of people. It follows that data sharing is not so widespread among archaeologists, and dissemination of research is still mostly based on traditional pre-digital means like scientific papers, journal articles and books. This project has implemented a web approach for sharing and communication purposes, exploiting mainly open source technologies which allow a high level of interactivity. The case study presented is the newly Mithraeum excavated in Ostia Antica archaeological site in the framework of the Ostia Marina Project.

Newly reported lupus and rheumatoid arthritis in relation to deployment within proximity to a documented open-air burn pit in Iraq.

PubMed

Jones, Kelly A; Smith, Besa; Granado, Nisara S; Boyko, Edward J; Gackstetter, Gary D; Ryan, Margaret A K; Phillips, Christopher J; Smith, Tyler C

2012-06-01

To assess the relationship between possible exposure to smoke from documented open-air burn pits and newly reported lupus and rheumatoid arthritis among Millennium Cohort participants who have deployed in support of operations in Iraq and Afghanistan. Prospectively assessed self-reported lupus and rheumatoid arthritis among deployers who completed both 2004-2006 and 2007-2008 questionnaires. After exclusions, more than 18,000 participants were deployed, including more than 3000 participants deployed within a 3-mile radius of a documented burn pit. After adjustment, proximity within 3 miles of a burn pit was not significantly associated with rheumatoid arthritis or lupus in general; however, one location was associated with lupus, although few cases were at this site (n = 2). Results indicate deployers potentially exposed to documented burn pits in the combined three-camp analysis were not at an elevated risk of lupus or rheumatoid arthritis.

The effects of exposure to documented open-air burn pits on respiratory health among deployers of the Millennium Cohort Study.

PubMed

Smith, Besa; Wong, Charlene A; Boyko, Edward J; Phillips, Christopher J; Gackstetter, Gary D; Ryan, Margaret A K; Smith, Tyler C

2012-06-01

To investigate respiratory illnesses and potential open-air burn pit exposure among Millennium Cohort participants who deployed to Iraq or Afghanistan. Using multivariable logistic regression, newly reported chronic bronchitis or emphysema, newly reported asthma, and self-reported respiratory symptoms and possible burn pit exposure within 2, 3, or 5 miles were examined among Army and Air Force deployers surveyed in 2004 to 2006 and 2007 to 2008 (n = 22,844). Burn pit exposure within 3 or 5 miles was not associated with respiratory outcomes after statistical adjustment. Increased symptom reporting was observed among Air Force deployers located within 2 miles of Joint Base Balad; however, this finding was marginally significant with no evidence of trend. In general, these findings do not support an elevated risk for respiratory outcomes among personnel deployed within proximity of documented burn pits in Iraq.

Field Performance of a Newly Developed Upflow Filtration Device

EPA Science Inventory

The objective of this research is to examine the removal capacities of a newly developed Upflow filtration device for treatment of stormwater. The device was developed by engineers at the University of Alabama through a Small Business Innovative Research (SBIR) grant from the U....

Postreplication Repair of Ultraviolet Damage in Haemophilus influenzae

PubMed Central

Leclerc, J. Eugene; Setlow, Jane K.

1972-01-01

The deoxyribonucleic acid (DNA) synthesized following ultraviolet (UV) irradiation of wild-type (Rd) and recombination-defective strains of Haemophilus influenzae has been analyzed by alkaline sucrose gradient sedimentation. Strain Rd and a UV-resistant, recombination-defective strain Rd(DB117) rec− are able to carry out postreplication repair, i.e., close the single-strand gaps in the newly synthesized DNA; in the UV-sensitive, recombination-defective strain DB117, the gaps remain open. The lack of postreplication repair in this strain may be the result of degradation of the newly synthesized DNA. PMID:4537422

Adrenocortical Carcinoma Treatment (PDQ®)—Health Professional Version

Cancer.gov

Adrenocortical carcinoma (ACC or adrenal cancer) treatment is usually radical open complete resection and may include chemotherapy and radiation. Get detailed information about the prognosis and treatment of newly diagnosed and recurrent ACC in this comprehensive summary for clinicians.

Competitive replication kinetics and pathogenicity in pigs co-infected with historical and newly invading classical swine fever viruses.

PubMed

Huang, Yu-Liang; Deng, Ming-Chung; Tsai, Kuo-Jung; Liu, Hsin-Meng; Huang, Chin-Cheng; Wang, Fun-In; Chang, Chia-Yi

2017-01-15

Classical swine fever (CSF), an economically important and highly contagious disease of pigs, is caused by classical swine fever virus (CSFV). In Taiwan, CSFVs from field outbreaks belong to two distinct genotypes. The historical genotype 3.4 dominated from the 1920s to 1996, and since 1996, the newly invading genotype 2.1 has dominated. To explain the phenomenon of this virus shift in the field, representative viruses belonging to genotypes 2.1 and 3.4 were either inoculated alone (single infection) or co-inoculated (co-infection), both in vivo and in vitro, to compare the virus replication and pathogenesis. In pigs co-infected with the genotype 2.1 TD/96/TWN strain and the genotype 3.4 94.4/IL/94/TWN strain, the newly invading genotype 2.1 was detected earlier in the blood, oral fluid, and feces, and the viral loads were consistently and significantly higher than that of the historical genotype 3.4. In cell cultures, the ratio of secreted virus to cell-associated virus of the genotype 2.1 strain was higher than that of the genotype 3.4 strain. This study is the first to demonstrate a possible explanation of virus shift in the field, wherein the newly invading genotype 2.1 replicates more efficiently than did genotype 3.4 and outcompetes the replication and pathogenicity of genotype 3.4 in pigs in the field. Copyright © 2016 Elsevier B.V. All rights reserved.

Enhancing the Employability of Newly Qualified Nurses: A Pilot Study

ERIC Educational Resources Information Center

Dray, Beattie; Burke, Linda; Hurst, Heather M.; Ferguson, Anne; Marks-Maran, Diane

2011-01-01

Vocationally based higher education programmes are meant to prepare people for employment in their chosen fields of study. In nursing, historically, employment after qualifying has been almost assured, with sufficient vacancies available for newly qualified nurses. Recently, however, for a number of reasons, primarily related to economic…

AmeriFlux US-Tw4 Twitchell East End Wetland

DOE Data Explorer

Baldocchi, Dennis [University of California, Berkeley

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Tw4 Twitchell East End Wetland. Site Description - The Twitchell East End Wetland is a newly constructed restored wetland on Twitchell Island, CA. This site and the surrounding region are part of the San Joaquin - Sacramento River Delta drained beginning in the 1850's and subsequently used for agriculture. The site was previously a corn field. The wetland was designed to have a mix of vegetated and open water channels and ponds (due to surface elevation differences). Flooding of the wetland was done gradually beginning in January, 2014. Berms wind throughout the wetland to allow vehicle access. Tule and Cattail plant material from a nearby wetland were spread along the berms immediately prior to flooding to facilitate plant establishment and stabilization of the berms from wind/water erosion. The tower was installed on November 25, 2013.

Noise Response Data Reveal Novel Controllability Gramian for Nonlinear Network Dynamics

PubMed Central

Kashima, Kenji

2016-01-01

Control of nonlinear large-scale dynamical networks, e.g., collective behavior of agents interacting via a scale-free connection topology, is a central problem in many scientific and engineering fields. For the linear version of this problem, the so-called controllability Gramian has played an important role to quantify how effectively the dynamical states are reachable by a suitable driving input. In this paper, we first extend the notion of the controllability Gramian to nonlinear dynamics in terms of the Gibbs distribution. Next, we show that, when the networks are open to environmental noise, the newly defined Gramian is equal to the covariance matrix associated with randomly excited, but uncontrolled, dynamical state trajectories. This fact theoretically justifies a simple Monte Carlo simulation that can extract effectively controllable subdynamics in nonlinear complex networks. In addition, the result provides a novel insight into the relationship between controllability and statistical mechanics. PMID:27264780

Theory and applications of the polymerase chain reaction.

PubMed

Remick, D G; Kunkel, S L; Holbrook, E A; Hanson, C A

1990-04-01

The polymerase chain reaction (PCR) is a newly developed molecular biology technique that can significantly amplify DNA or RNA. The process consists of repetitive cycles of specific DNA synthesis, defined by short stretches of preselected DNA. With each cycle, there is a doubling of the final, desired DNA product such that a million-fold amplification is possible. This powerful method has numerous applications in diagnostic pathology, especially in the fields of microbiology, forensic science, and hematology. The PCR may be used to directly detect viral DNA, which may facilitate the diagnosis of acquired immune deficiency syndrome (AIDS) or other viral diseases. PCR amplification of DNA allows detection of specific sequences from extremely small samples, such as with forensic material. In hematology, PCR may help in the diagnosis of hemoglobinopathies or of neoplastic disorders by documenting chromosomal translocations. The new PCR opens exciting new avenues for diagnostic pathology using this new technology.

Solar Wind Acceleration: Modeling Effects of Turbulent Heating in Open Flux Tubes

NASA Astrophysics Data System (ADS)

Woolsey, Lauren N.; Cranmer, Steven R.

2014-06-01

We present two self-consistent coronal heating models that determine the properties of the solar wind generated and accelerated in magnetic field geometries that are open to the heliosphere. These models require only the radial magnetic field profile as input. The first code, ZEPHYR (Cranmer et al. 2007) is a 1D MHD code that includes the effects of turbulent heating created by counter-propagating Alfven waves rather than relying on empirical heating functions. We present the analysis of a large grid of modeled flux tubes (> 400) and the resulting solar wind properties. From the models and results, we recreate the observed anti-correlation between wind speed at 1 AU and the so-called expansion factor, a parameterization of the magnetic field profile. We also find that our models follow the same observationally-derived relation between temperature at 1 AU and wind speed at 1 AU. We continue our analysis with a newly-developed code written in Python called TEMPEST (The Efficient Modified-Parker-Equation-Solving Tool) that runs an order of magnitude faster than ZEPHYR due to a set of simplifying relations between the input magnetic field profile and the temperature and wave reflection coefficient profiles. We present these simplifying relations as a useful result in themselves as well as the anti-correlation between wind speed and expansion factor also found with TEMPEST. Due to the nature of the algorithm TEMPEST utilizes to find solar wind solutions, we can effectively separate the two primary ways in which Alfven waves contribute to solar wind acceleration: 1) heating the surrounding gas through a turbulent cascade and 2) providing a separate source of wave pressure. We intend to make TEMPEST easily available to the public and suggest that TEMPEST can be used as a valuable tool in the forecasting of space weather, either as a stand-alone code or within an existing modeling framework.

Applying an Archetype-Based Approach to Electroencephalography/Event-Related Potential Experiments in the EEGBase Resource.

PubMed

Papež, Václav; Mouček, Roman

2017-01-01

The purpose of this study is to investigate the feasibility of applying openEHR (an archetype-based approach for electronic health records representation) to modeling data stored in EEGBase, a portal for experimental electroencephalography/event-related potential (EEG/ERP) data management. The study evaluates re-usage of existing openEHR archetypes and proposes a set of new archetypes together with the openEHR templates covering the domain. The main goals of the study are to (i) link existing EEGBase data/metadata and openEHR archetype structures and (ii) propose a new openEHR archetype set describing the EEG/ERP domain since this set of archetypes currently does not exist in public repositories. The main methodology is based on the determination of the concepts obtained from EEGBase experimental data and metadata that are expressible structurally by the openEHR reference model and semantically by openEHR archetypes. In addition, templates as the third openEHR resource allow us to define constraints over archetypes. Clinical Knowledge Manager (CKM), a public openEHR archetype repository, was searched for the archetypes matching the determined concepts. According to the search results, the archetypes already existing in CKM were applied and the archetypes not existing in the CKM were newly developed. openEHR archetypes support linkage to external terminologies. To increase semantic interoperability of the new archetypes, binding with the existing odML electrophysiological terminology was assured. Further, to increase structural interoperability, also other current solutions besides EEGBase were considered during the development phase. Finally, a set of templates using the selected archetypes was created to meet EEGBase requirements. A set of eleven archetypes that encompassed the domain of experimental EEG/ERP measurements were identified. Of these, six were reused without changes, one was extended, and four were newly created. All archetypes were arranged in the templates reflecting the EEGBase metadata structure. A mechanism of odML terminology referencing was proposed to assure semantic interoperability of the archetypes. The openEHR approach was found to be useful not only for clinical purposes but also for experimental data modeling.

Optimization of computations for adjoint field and Jacobian needed in 3D CSEM inversion

NASA Astrophysics Data System (ADS)

Dehiya, Rahul; Singh, Arun; Gupta, Pravin K.; Israil, M.

2017-01-01

We present the features and results of a newly developed code, based on Gauss-Newton optimization technique, for solving three-dimensional Controlled-Source Electromagnetic inverse problem. In this code a special emphasis has been put on representing the operations by block matrices for conjugate gradient iteration. We show how in the computation of Jacobian, the matrix formed by differentiation of system matrix can be made independent of frequency to optimize the operations at conjugate gradient step. The coarse level parallel computing, using OpenMP framework, is used primarily due to its simplicity in implementation and accessibility of shared memory multi-core computing machine to almost anyone. We demonstrate how the coarseness of modeling grid in comparison to source (comp`utational receivers) spacing can be exploited for efficient computing, without compromising the quality of the inverted model, by reducing the number of adjoint calls. It is also demonstrated that the adjoint field can even be computed on a grid coarser than the modeling grid without affecting the inversion outcome. These observations were reconfirmed using an experiment design where the deviation of source from straight tow line is considered. Finally, a real field data inversion experiment is presented to demonstrate robustness of the code.

Shear viscosity coefficient of liquid lanthanides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patel, H. P., E-mail: patel.harshal2@gmail.com; Thakor, P. B., E-mail: pbthakore@rediffmail.com; Prajapati, A. V., E-mail: anand0prajapati@gmail.com

2015-05-15

Present paper deals with the computation of shear viscosity coefficient (η) of liquid lanthanides. The effective pair potential v(r) is calculated through our newly constructed model potential. The Pair distribution function g(r) is calculated from PYHS reference system. To see the influence of local field correction function, Hartree (H), Tailor (T) and Sarkar et al (S) local field correction function are used. Present results are compared with available experimental as well as theoretical data. Lastly, we found that our newly constructed model potential successfully explains the shear viscosity coefficient (η) of liquid lanthanides.

Shear viscosity coefficient of liquid lanthanides

NASA Astrophysics Data System (ADS)

Patel, H. P.; Sonvane, Y. A.; Thakor, P. B.; Prajapati, A. V.

2015-05-01

Present paper deals with the computation of shear viscosity coefficient (η) of liquid lanthanides. The effective pair potential v(r) is calculated through our newly constructed model potential. The Pair distribution function g(r) is calculated from PYHS reference system. To see the influence of local field correction function, Hartree (H), Tailor (T) and Sarkar et al (S) local field correction function are used. Present results are compared with available experimental as well as theoretical data. Lastly, we found that our newly constructed model potential successfully explains the shear viscosity coefficient (η) of liquid lanthanides.

The newly expanded KSC Visitors Complex features a new ticket plaza, information center, exhibits an

NASA Technical Reports Server (NTRS)

1999-01-01

At the grand opening of the newly expanded KSC Visitor Complex, Center Director Roy Bridges addresses guests and the media. The $13 million addition to the Visitor Complex includes an International Space Station-themed ticket plaza, featuring a structure of overhanging solar panels and astronauts performing assembly tasks, a new information center, films, and exhibits. The KSC Visitor Complex was inaugurated three decades ago and is now one of the top five tourist attractions in Florida. It is located on S.R. 407, east of I-95, within the Merritt Island National Wildlife Refuge.

Serpentinomics-an emerging new field of study

Treesearch

Jessica Wright; Eric von Wettberg

2009-01-01

"Serpentinomics" is an emerging field of study which has the potential to greatly advance our understanding of serpentine ecology. Several newly developing –omic fields, often using high-throughput tools developed for molecular biology, will advance the field of serpentine ecology, or, "serpentinomics." Using tools from the...

Sugarcane White Leaf Disease Incidences and Population Dynamic of Leafhopper Insect Vectors in Sugarcane Plantations in Northeast Thailand.

PubMed

Rattanabunta, Chiranan; Hanboonsong, Yupa

2015-04-01

The work consisted of two experiments, i.e. Experiment 1 was conducted under controlled environments where sugarcane plants were used as hosts. This investigation aimed to monitor the occurrence of the Sugarcane White Leaf disease and the abundance of Leafhopper insect vectors and also the work aimed to provide useful information in understanding some aspects on epidemiology of the Sugarcane White Leaf disease. A Completely Randomized Design with three replications was used to justify growth and development of Leafhopper insects as affected by different temperatures: 20 (T1), 25 (T2), 30 (T3) and 35 degrees C (T4). Experiment 2 was carried out to determine the numbers of Leafhopper insects with the use of light traps in the sugarcane Field 1 (ratoon plants), Field 2 (newly planted), Field 3 (newly planted) and Field 4 (ratoon plants). The results of Experiment 1 showed that growth and development of Leafhopper insects were highly affected by temperatures i.e. the higher the environmental temperature the faster the growth and development of the insects to reach its full adulthood. At 20 degrees C, Leafhopper insects took 12 days to lay eggs whereas at 25 degrees C the insects took only 6 days. Male reached its adulthood approximately 9 days earlier than female when cultured at 25 degrees C and became approximately one week at 30 degrees C or higher. The results of Experiment 2 showed that the majority of Leafhopper insects were found within the months of June and July for both newly planted and ratoon crops. A small amount was found in May and August with an exceptional case of Field 4 where the highest number of Leafhopper insects was found in April followed by June and July. For Sugarcane White Leaf disease, the disease was found in all months of the year except February for Fields 2 and 3. Newly planted sugarcane plants attained much smaller percentages of disease than those of the ratoon plants.

Does microblogging convey firm-specific information? Evidence from China

NASA Astrophysics Data System (ADS)

Shen, Dehua; Li, Xiao; Xue, Mei; Zhang, Wei

2017-09-01

This paper investigates the impact of opening microblogging account in Sina Weibo on the diffusion of firm-specific information in Chinese stock market. With the unique sample of firms opening their official accounts, the empirical results show that this newly emerged information diffusion channel, i.e., Sina Weibo, plays an important role in conveying firm-specific information to the market. Generally speaking, these empirical findings have practical implications to securities regulators who have interest in monitoring the diffused information via social media.

Strong IMF By-Related Plasma Convection in the Ionosphere and Cusp Field-Aligned Currents Under Northward IMF Conditions

NASA Technical Reports Server (NTRS)

Le, G.; Lu, G.; Strangeway, R. J.; Pfaff, R. F., Jr.; Vondrak, Richard R. (Technical Monitor)

2001-01-01

We present in this paper an investigation of IMF-By related plasma convection and cusp field-aligned currents using FAST data and AMIE model during a prolonged interval with large positive IMF By and northward Bz conditions (By/Bz much greater than 1). Using the FAST single trajectory observations to validate the global convection patterns at key times and key locations, we have demonstrated that the AMIE procedure provides a reasonably good description of plasma circulations in the ionosphere during this interval. Our results show that the plasma convection in the ionosphere is consistent with the anti-parallel merging model. When the IMF has a strongly positive By component under northward conditions, we find that the global plasma convection forms two cells oriented nearly along the Sun-earth line in the ionosphere. In the northern hemisphere, the dayside cell has clockwise convection mainly circulating within the polar cap on open field lines. A second cell with counterclockwise convection is located in the nightside circulating across the polar cap boundary, The observed two-cell convection pattern appears to be driven by the reconnection along the anti-parallel merging lines poleward of the cusp extending toward the dusk side when IMF By/Bz much greater than 1. The magnetic tension force on the newly reconnected field lines drives the plasma to move from dusk to dawn in the polar cusp region near the polar cap boundary. The field-aligned currents in the cusp region flow downward into the ionosphere. The return field-aligned currents extend into the polar cap in the center of the dayside convection cell. The field-aligned currents are closed through the Peterson currents in the ionosphere, which flow poleward from the polar cap boundary along the electric field direction.

New light field camera based on physical based rendering tracing

NASA Astrophysics Data System (ADS)

Chung, Ming-Han; Chang, Shan-Ching; Lee, Chih-Kung

2014-03-01

Even though light field technology was first invented more than 50 years ago, it did not gain popularity due to the limitation imposed by the computation technology. With the rapid advancement of computer technology over the last decade, the limitation has been uplifted and the light field technology quickly returns to the spotlight of the research stage. In this paper, PBRT (Physical Based Rendering Tracing) was introduced to overcome the limitation of using traditional optical simulation approach to study the light field camera technology. More specifically, traditional optical simulation approach can only present light energy distribution but typically lack the capability to present the pictures in realistic scenes. By using PBRT, which was developed to create virtual scenes, 4D light field information was obtained to conduct initial data analysis and calculation. This PBRT approach was also used to explore the light field data calculation potential in creating realistic photos. Furthermore, we integrated the optical experimental measurement results with PBRT in order to place the real measurement results into the virtually created scenes. In other words, our approach provided us with a way to establish a link of virtual scene with the real measurement results. Several images developed based on the above-mentioned approaches were analyzed and discussed to verify the pros and cons of the newly developed PBRT based light field camera technology. It will be shown that this newly developed light field camera approach can circumvent the loss of spatial resolution associated with adopting a micro-lens array in front of the image sensors. Detailed operational constraint, performance metrics, computation resources needed, etc. associated with this newly developed light field camera technique were presented in detail.

Open-source meteor detection software for low-cost single-board computers

NASA Astrophysics Data System (ADS)

Vida, D.; Zubović, D.; Šegon, D.; Gural, P.; Cupec, R.

2016-01-01

This work aims to overcome the current price threshold of meteor stations which can sometimes deter meteor enthusiasts from owning one. In recent years small card-sized computers became widely available and are used for numerous applications. To utilize such computers for meteor work, software which can run on them is needed. In this paper we present a detailed description of newly-developed open-source software for fireball and meteor detection optimized for running on low-cost single board computers. Furthermore, an update on the development of automated open-source software which will handle video capture, fireball and meteor detection, astrometry and photometry is given.

Establishing a sediment budget in the newly created "Kleine Noordwaard" wetland area in the Rhine-Meuse delta

NASA Astrophysics Data System (ADS)

Christien van der Deijl, Eveline; van der Perk, Marcel; Middelkoop, Hans

2018-03-01

Many deltas are threatened by accelerated soil subsidence, sea-level rise, increasing river discharge, and sediment starvation. Effective delta restoration and effective river management require a thorough understanding of the mechanisms of sediment deposition, erosion, and their controls. Sediment dynamics has been studied at floodplains and marshes, but little is known about the sediment dynamics and budget of newly created wetlands. Here we take advantage of a recently opened tidal freshwater system to study both the mechanisms and controls of sediment deposition and erosion in newly created wetlands. We quantified both the magnitude and spatial patterns of sedimentation and erosion in a former polder area in which water and sediment have been reintroduced since 2008. Based on terrestrial and bathymetric elevation data, supplemented with field observations of the location and height of cut banks and the thickness of the newly deposited layer of sediment, we determined the sediment budget of the study area for the period 2008-2015. Deposition primarily took place in channels in the central part of the former polder area, whereas channels near the inlet and outlet of the area experienced considerable erosion. In the intertidal area, sand deposition especially takes place at low-lying locations close to the channels. Mud deposition typically occurs further away from the channels, but sediment is in general uniformly distributed over the intertidal area, due to the presence of topographic irregularities and micro-topographic flow paths. Marsh erosion does not significantly contribute to the total sediment budget, because wind wave formation is limited by the length of the fetch. Consecutive measurements of channel bathymetry show a decrease in erosion and deposition rates over time, but the overall results of this study indicate that the area functions as a sediment trap. The total contemporary sediment budget of the study area amounts to 35.7×103 m3 year-1, which corresponds to a net area-averaged deposition rate of 6.1 mm year-1. This is enough to compensate for the actual rates of sea-level rise and soil subsidence in the Netherlands.

Cost-effectiveness of the long-term use of temozolomide for treating newly diagnosed glioblastoma in Germany.

PubMed

Waschke, Albrecht; Arefian, Habibollah; Walter, Jan; Hartmann, Michael; Maschmann, Jens; Kalff, Rolf

2018-06-01

Concomitant radiochemotherapy followed by six cycles of temozolomide (= short term) is considered as standard therapy for adults with newly diagnosed glioblastoma. In contrast, open-end administration of temozolomide until progression (= long-term) is proposed by some authors as a viable alternative. We aimed to determine the cost-effectiveness of long-term temozolomide therapy for patients newly diagnosed with glioblastoma compared to standard therapy. A Markov model was constructed to compare medical costs and clinical outcomes for both therapy types over a time horizon of 60 months. Transition probabilities for standard therapy were calculated from randomized controlled trial data by Stupp et al. The data for long-term temozolomide therapy was collected by matching a cohort treated in the Department of Neurosurgery at Jena University Hospital. Health utilities were obtained from a previous cost utility study. The cost perspective was based on health insurance. The base case analysis showed a median overall survival of 17.1 months and a median progression-free survival of 7.4 months for patients in the long-term temozolomide therapy arm. The cost-effectiveness analysis using all base case parameters in a time-dependent Markov model resulted in an incremental effectiveness of 0.022 quality-adjusted life-years (QALYs). The incremental cost-effectiveness ratio (ICER) was €351,909/QALY. Sensitivity analyses showed that parameters with the most influence on ICER were the health state utility of progression in both therapy arms. Although open-ended temozolomide therapy is very expensive, the ICER of this therapy is comparable to that of the standard temozolomide therapy for patients newly diagnosed with glioblastoma.

Advantages of using newly developed quartz contact lens with slit illumination from operating microscope.

PubMed

Kiyokawa, Masatoshi; Sakuma, Toshiro; Hatano, Noriko; Mizota, Atsushi; Tanaka, Minoru

2009-06-01

The purpose of this article is to report the characteristics and advantages of using a newly designed quartz contact lens with slit illumination from an operating microscope for intraocular surgery. The new contact lens is made of quartz. The lens is convex-concave and is used in combination with slit illumination from an operating microscope. The optical properties of quartz make this lens less reflective with greater transmittance. The combination of a quartz contact lens with slit illumination provided a brighter and wider field of view than conventional lenses. This system enabled us to perform bimanual vitrectomy and scleral buckling surgery without indirect ophthalmoscope. Small intraocular structures in the posterior pole or in the periphery were detected more easily. In conclusion, the newly designed quartz lens with slit beam illumination from an operating microscope provided a bright, clear and wide surgical field, and allowed intraocular surgery to be performed more easily.

Wide-Field Infrared Survey Explorer Observations of the Evolution of Massive Star-Forming Regions

NASA Technical Reports Server (NTRS)

Koenig, X. P.; Leisawitz, D. T.; Benford, D. J.; Rebull, L. M.; Padgett, D. L.; Assef, R. J.

2011-01-01

We present the results of a mid-infrared survey of 11 outer Galaxy massive star-forming regions and 3 open clusters with data from the Wide-field Infrared Survey Explorer (WISE). Using a newly developed photometric scheme to identify young stellar objects and exclude extragalactic contamination, we have studied the distribution of young stars within each region. These data tend to support the hypothesis that latter generations may be triggered by the interaction of winds and radiation from the first burst of massive star formation with the molecular cloud material leftover from that earlier generation of stars.We dub this process the "fireworks hypothesis" since star formation by this mechanism would proceed rapidly and resemble a burst of fireworks.We have also analyzed small cutout WISE images of the structures around the edges of these massive star-forming regions. We observe large (1-3 pc size) pillar and trunk-like structures of diffuse emission nebulosity tracing excited polycyclic aromatic hydrocarbon molecules and small dust grains at the perimeter of the massive star-forming regions. These structures contain small clusters of emerging Class I and Class II sources, but some are forming only a single to a few new stars.

Wide-Field Infrared Survey Explorer Observations of the Evolution of Massive Star-Forming Regions

NASA Technical Reports Server (NTRS)

Koenig, X. P.; Leisawitz, D. T.; Benford, D. J.; Rebull, L. M.; Padgett, D. L.; Asslef, R. J.

2012-01-01

We present the results of a mid-infrared survey of II outer Galaxy massive star-forming regions and 3 open clusters with data from the Wide-field Infrared Survey Explorer (WISE). Using a newly developed photometric scheme to identify young stellar objects and exclude extragalactic contamination, we have studied the distribution of young stars within each region. These data tend to support the hypothesis that latter generations may be triggered by the interaction of winds and radiation from the first burst of massive star formation with the molecular cloud material leftover from that earlier generation of stars. We dub this process the "fireworks hypothesis" since star formation by this mechanism would proceed rapidly and resemble a burst of fireworks. We have also analyzed small cutout WISE images of the structures around the edges of these massive star-forming regions. We observe large (1-3 pc size) pillar and trunk-like structures of diffuse emission nebulosity tracing excited polycyclic aromatic hydrocarbon molecules and small dust grains at the perimeter of the massive star-forming regions. These structures contain small clusters of emerging Class I and Class II sources, but some are forming only a single to a few new stars.

A review of cardiopulmonary research in Brazilian medical journals: clinical, surgical and epidemiological data.

PubMed

Serrano, Carlos; Rocha e Silva, Mauricio

2010-04-01

Research in the field of cardiopulmonary disease in Brazil has been very active in recent decades. The combination of PUBMED, SCieLO, open access and online searching has provided a significant increase in the visibility of Brazilian journals. This newly acquired international visibility has in turn resulted in the appearance of more original research reports in the Brazilian scientific press. This review is intended to highlight part of this work for the benefit of the readers of "Clinics." We searched through PUBMED for noteworthy articles published in Brazilian medical journals included in the Journal of Citation Reports of the Institute of Scientific Information to better expose them to our readership. The following journals were examined: "Arquivos Brasileiros de Cardiologia," "Arquivos Brasileiros de Endocrinologia e Metabologia," "Brazilian Journal of Medical and Biological Reviews," "Jornal Brasileiro de Pneumologia," "Jornal de Pediatria," "Revista Brasileira de Cirurgia Cardiovascular," "Revista da Associação Médica Brasileira," Revista da Escola de Enfermagem U.S.P." and "São Paulo Medical Journal." These journals publish original investigations in the field of cardiopulmonary disease. The search produced 71 references, which are briefly examined.

AN ASTEROSEISMIC MEMBERSHIP STUDY OF THE RED GIANTS IN THREE OPEN CLUSTERS OBSERVED BY KEPLER: NGC 6791, NGC 6819, AND NGC 6811

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stello, Dennis; Huber, Daniel; Bedding, Timothy R.

Studying star clusters offers significant advances in stellar astrophysics due to the combined power of having many stars with essentially the same distance, age, and initial composition. This makes clusters excellent test benches for verification of stellar evolution theory. To fully exploit this potential, it is vital that the star sample is uncontaminated by stars that are not members of the cluster. Techniques for determining cluster membership therefore play a key role in the investigation of clusters. We present results on three clusters in the Kepler field of view based on a newly established technique that uses asteroseismology to identifymore » fore- or background stars in the field, which demonstrates advantages over classical methods such as kinematic and photometry measurements. Four previously identified seismic non-members in NGC 6819 are confirmed in this study, and three additional non-members are found-two in NGC 6819 and one in NGC 6791. We further highlight which stars are, or might be, affected by blending, which needs to be taken into account when analyzing these Kepler data.« less

Open Trial of an Acceptance-Based Behavior Therapy Intervention to Engage Newly Diagnosed HIV Patients in Care: Rationale and Evidence of Feasibility and Acceptability.

PubMed

Moitra, Ethan; Chan, Philip A; Stein, Michael D

2015-09-01

Successful linkage and retention in care of newly diagnosed individuals in the United States remains a significant gap in the HIV care continuum. This study assessed the acceptability and feasibility of an acceptance-based behavior therapy (ABBT) intervention to engage patients newly diagnosed with HIV in medical care. Nine patients were recruited over 4 months for this brief ABBT intervention, which consisted of two brief sessions, each lasting less than 20 min. The intervention was developed to promote psychological acceptance of the HIV diagnosis, thereby increasing patients' willingness to make informed disclosure of their status. Eight patients completed a 1-month follow-up assessment, and all approved of the intervention and its components. Over the 1-month period, participants showed increased acceptance, reduced perceptions of HIV stigmatization, and increased disclosure of HIV status to social supports. This pilot study provided support for the continued investigation of ABBT as an adjunctive intervention for newly diagnosed HIV patients who are at high-risk of dropping out of HIV care. © The Author(s) 2015.

H{α} Surges Aroused by Newly-emerging Satellite Bipolar Magnetic Field

NASA Astrophysics Data System (ADS)

Wang, J. F.; Zhou, T. H.; Ji, H. S.

2013-07-01

An Hα surge event occurred at AR NOAA 11259 on 2011 July 22. According to the BBSO (Big Bear Solar Observatory) Hα line-center observations, three surges continuously ejected from the same region to the north of the main-sunspot of AR 11259. All of surges ejected along a straight trajectory, and looked like the reversed Eiffel Tower. The first and second surges had the same process. Two bright points firstly appeared to the north of the main-sunspot. After several minutes, a surge appeared between the two bright points, and then rapidly ejected when the two points got most brightness.When the surge reached the maximum height, it disappeared quickly. However, the third surge appeared without bright points, and its height was only half of the others. Compared with SDO/HMI (Solar Dynamics Observatory/Helioseismic and Magnetic Imager) line-of-sight magnetogram, more than one hour before the first surge appeared, a satellite bipolar magnetic field emerged from the surge-ejection region. The newly-emerging positive magnetic flux showed a distinct decrease several minutes earlier than the ejection of the surges. We assumed that the surges was associated with the reconnection between the newly-emerging bipolar magnetic field and the existing (sunspot) magnetic field.

Evolution of an experimental population of Phytophthora capsici in the field

USDA-ARS?s Scientific Manuscript database

Populations of the vegetable pathogen Phytophthora capsici are often highly diverse, with limited gene flow between fields. To investigate the structure of a newly established, experimental population, an uninfested research field was inoculated with two single zoospore isolates of P. capsici in Sep...

DETECTION OF A STELLAR STREAM BEHIND OPEN CLUSTER NGC 188: ANOTHER PART OF THE MONOCEROS STREAM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casetti-Dinescu, Dana I.; Girard, Terrence M.; Van Altena, William F.

2010-05-15

We present results from a WIYN/Orthogonal Parallel Transfer Imaging Camera photometric and astrometric survey of the field of the open cluster NGC 188 ((l, b) = (122.{sup 0}8, 22.{sup 0}5)). We combine these results with the proper-motion and photometry catalog of Platais et al. and demonstrate the existence of a stellar overdensity in the background of NGC 188. The theoretical isochrone fits to the color-magnitude diagram of the overdensity are consistent with an age between 6 and 10 Gyr and an intermediately metal poor population ([Fe/H] = -0.5 to -1.0). The distance to the overdensity is estimated to be betweenmore » 10.0 and 12.6 kpc. The proper motions indicate that the stellar population of the overdensity is kinematically cold. The distance estimate and the absolute proper motion of the overdensity agree reasonably well with the predictions of the Penarrubia et al. model of the formation of the Monoceros stream. Orbits for this material constructed with plausible radial-velocity values, indicate that dynamically, this material is unlikely to belong to the thick disk. Taken together, this evidence suggests that the newly found overdensity is part of the Monoceros stream.« less

MEA-Tools: an open source toolbox for the analysis of multi-electrode data with MATLAB.

PubMed

Egert, U; Knott, Th; Schwarz, C; Nawrot, M; Brandt, A; Rotter, S; Diesmann, M

2002-05-30

Recent advances in electrophysiological techniques have created new tools for the acquisition and storage of neuronal activity recorded simultaneously with numerous electrodes. These techniques support the analysis of the function as well as the structure of individual electrogenic cells in the context of surrounding neuronal or cardiac network. Commercially available tools for the analysis of such data, however, cannot be easily adapted to newly emerging requirements for data analysis and visualization, and cross compatibility between them is limited. In this report we introduce a free open source toolbox called microelectrode array tools (MEA-Tools) for the analysis of multi-electrode data based on the common data analysis environment MATLAB (version 5.3-6.1, The Mathworks, Natick, MA). The toolbox itself is platform independent. The file interface currently supports files recorded with MCRack (Multi Channel Systems, Reutlingen, Germany) under Microsoft Windows 95, 98, NT, and 2000, but can be adapted to other data acquisition systems. Functions are controlled via command line input and graphical user interfaces, and support common requirements for the analysis of local field potentials, extracellular spike activity, and continuous recordings, in addition to supplementary data acquired by additional instruments, e.g. intracellular amplifiers. Data may be processed as continuous recordings or time windows triggered to some event.

Implementation and application of the actuator line model by OpenFOAM for a vertical axis wind turbine

NASA Astrophysics Data System (ADS)

Riva, L.; Giljarhus, K.-E.; Hjertager, B.; Kalvig, S. M.

2017-12-01

University of Stavanger has started The Smart Sustainable Campus & Energy Lab project, to gain knowledge and facilitate project based education in the field of renewable and sustainable energy and increase the research effort in the same area. This project includes the future installation of a vertical axis wind turbine on the campus roof. A newly developed Computational Fluid Dynamics (CFD) model by OpenFOAM have been implemented to study the wind behavior over the building and the turbine performance. The online available wind turbine model case from Bachant, Goude and Wosnik from 2016 is used as the starting point. This is a Reynolds-Averaged Navier-Stokes equations (RANS) case set up that uses the Actuator Line Model. The available test case considers a water tank with controlled external parameters. Bachant et al.’s model has been modified to study a VAWT in the atmospheric boundary layer. Various simulations have been performed trying to verify the models use and suitability. Simulation outcomes help to understand the impact of the surroundings on the turbine as well as its reaction to parameters changes. The developed model can be used for wind energy and flow simulations for both onshore and offshore applications.

MLC-based penumbra softener of EDW borders to reduce junction inhomogeneities.

PubMed

Szpala, Stanislaw; Kohli, Kirpal

2017-05-01

Junctions of fields are known to be susceptible to developing cold or hot spots in the presence of even small geometrical misalignments. Reduction of these dose inhomogeneities can be accomplished through decreasing the dose gradients in the penumbra, but currently it cannot be done for enhanced dynamic wedges (EDW). An MLC-based penumbra softener was developed in the developer mode of TrueBeam linacs to reduce dose gradients across the side border of EDWs. The movement of each leaf was individually synchronized with the movement of the dynamic Y jaw to soften the penumbra in the same manner along the entire field border, in spite of the presence of the dose gradient of the EDW. Junction homogeneity upon field misalignment for side-matched EDWs was examined with the MV imager. The fluence inhomogeneities were reduced from about 30% per mm of shift of the field borders for the conventional EDW to about 2% per mm for the softened-penumbra plan. The junction in a four-field monoisocentric breast plan delivered to the Rando phantom was assessed with film. The dose inhomogeneities across the junction in the superior-inferior direction were reduced from about 20% to 25% per mm for the conventional fields to about 5% per mm. The dose near the softened junction of the breast plan with no shifts did not deviate from the conventional plan by more than about 4%. The newly-developed softened-penumbra junction of EDW (and/or open) fields was shown to reduce sensitivity to misalignments without increasing complexity of the planning or delivery. This methodology needs to be adopted by the manufacturers for clinical use. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Preceptors' perceptions of the elements of a successful and an unsuccessful orientation period for newly graduated nurses.

PubMed

Lindfors, Kirsi; Meretoja, Riitta; Kaunonen, Marja; Paavilainen, Eija

2018-04-01

To identify existing orientation patterns and to find elements that may enhance or impede successful orientation of newly graduated nurses. Preceptors have first-hand information concerning orientation and their opinions should not be forgotten when organisations develop their orientation processes. An open-ended questionnaire was undertaken to collect data from preceptors (n = 172) about the current orientation patterns. Data were analysed by using deductive content analysis and by quantifying the phrases. Communal commitment to the orientation process, strong professional orientation know-how and supportive leadership were the enhancing elements of successful orientation. Complex interpersonal relationship problems during orientation, inadequate orientation resources and the organisation's structural and functional problems were the impeding elements of successful orientation. With the elements of successful orientation we ensure a supportive transition to practice for newly graduate nurses and possibilities to focus on good orientation practices for preceptors. Nurse leaders play an important part in ensuring newly graduated nurses have a safe nursing career starting point and, for preceptors, opportunities to provide orientation that is as good as possible. Supportive leadership, sufficient resources and good interpersonal relationships should be the leading principles during newly graduated nurses' orientation period. © 2017 John Wiley & Sons Ltd.

Aerial Views of KSC

NASA Image and Video Library

2003-07-23

This aerial view, looking northwest, shows the newly opened Space Commerce Way that winds from S.R 3 on the right to its exit on S.R. 405 (near the top) in the background. The road is the new public access from Merritt Island to the KSC Visitor Complex (seen at top).

Gidzenko at ISS hatch

NASA Image and Video Library

2001-02-10

ISS01-E-5325 (10 February 2001) --- Cosmonaut Yuri P. Gidzenko, Expedition One Soyuz commander, stands near the hatch leading from the Unity node into the newly attached Destiny laboratory aboard the International Space Station (ISS). The picture was recorded with a digital still camera on the day the hatch was initially opened.

Not Watching the Fight: Examining the Dynamics of School Turnaround

ERIC Educational Resources Information Center

Corrales, Antonio

2017-01-01

This case describes how a newly appointed superintendent implemented systematic changes across the school district to increase academic performance and keep schools open and operational. The district superintendent and leadership team were forced by the state educational system to promote rapid and drastic organizational and academic changes to…

Using OpenMP vs. Threading Building Blocks for Medical Imaging on Multi-cores

NASA Astrophysics Data System (ADS)

Kegel, Philipp; Schellmann, Maraike; Gorlatch, Sergei

We compare two parallel programming approaches for multi-core systems: the well-known OpenMP and the recently introduced Threading Building Blocks (TBB) library by Intel®. The comparison is made using the parallelization of a real-world numerical algorithm for medical imaging. We develop several parallel implementations, and compare them w.r.t. programming effort, programming style and abstraction, and runtime performance. We show that TBB requires a considerable program re-design, whereas with OpenMP simple compiler directives are sufficient. While TBB appears to be less appropriate for parallelizing existing implementations, it fosters a good programming style and higher abstraction level for newly developed parallel programs. Our experimental measurements on a dual quad-core system demonstrate that OpenMP slightly outperforms TBB in our implementation.

Applications of Sunphotometry to Aerosol Extinction and Surface Anisotropy

NASA Technical Reports Server (NTRS)

Tsay, S. C.; Holben, B. N.; Privette, J. L.

2005-01-01

Support cost-sharing of a newly developed sunphotometer in field deployment for aerosol studies. This is a cost-sharing research to deploy a newly developed sun-sky-surface photometer for studying aerosol extinction and surface anisotropy at the ARM SGP, TWP, and NSA-AAO CART sites and in many field campaigns. Atmospheric aerosols affect the radiative energy balance of the Earth, both directly by perturbing the incoming/outgoing radiation fields and indirectly by influencing the properties/processes of clouds and reactive greenhouse gases. The surface bidirectional reflectance distribution function (BRDF) also plays a crucial role in the radiative energy balance, since the BRDF is required to determine (1) the spectral and spectrally-averaged surface albedo, and (2) the top-of-the-atmosphere (TOA) angular distribution of radiance field. Therefore, the CART sites provide an excellent, albeit unique, opportunity to collect long-term climatic data in characterizing aerosol properties and various types of surface anisotropy.

Crystallography Open Database (COD): an open-access collection of crystal structures and platform for world-wide collaboration

PubMed Central

Gražulis, Saulius; Daškevič, Adriana; Merkys, Andrius; Chateigner, Daniel; Lutterotti, Luca; Quirós, Miguel; Serebryanaya, Nadezhda R.; Moeck, Peter; Downs, Robert T.; Le Bail, Armel

2012-01-01

Using an open-access distribution model, the Crystallography Open Database (COD, http://www.crystallography.net) collects all known ‘small molecule / small to medium sized unit cell’ crystal structures and makes them available freely on the Internet. As of today, the COD has aggregated ∼150 000 structures, offering basic search capabilities and the possibility to download the whole database, or parts thereof using a variety of standard open communication protocols. A newly developed website provides capabilities for all registered users to deposit published and so far unpublished structures as personal communications or pre-publication depositions. Such a setup enables extension of the COD database by many users simultaneously. This increases the possibilities for growth of the COD database, and is the first step towards establishing a world wide Internet-based collaborative platform dedicated to the collection and curation of structural knowledge. PMID:22070882

Identification of a Linked Set of Genes in Serpulina hyodysenteriae (B204) Predicted To Encode Closely Related 39-Kilodalton Extracytoplasmic Proteins

PubMed Central

Gabe, Jeffrey D.; Dragon, Elizabeth; Chang, Ray-Jen; McCaman, Michael T.

1998-01-01

A tandem pair of nearly identical genes from Serpulina hyodysenteriae (B204) were cloned and sequenced. The full open reading frame of one gene and the partial open reading frame of the neighboring gene appear to encode secreted proteins which are homologous to, yet distinct from, the 39-kDa extracytoplasmic protein purified from the membrane fraction of S. hyodysenteriae. We have designated these newly identified genes vspA and vspB (for variable surface protein). PMID:9440540

The death of bioethics (as we once knew it).

PubMed

Macklin, Ruth

2010-06-01

Fast forward 50 years into the future. A look back at what occurred in the field of bioethics since 2010 reveals that a conference in 2050 commemorated the death of bioethics. In a steady progression over the years, the field became increasingly fragmented and bureaucratized. Disagreement and dissension were rife, and this once flourishing, multidisciplinary field began to splinter in multiple ways. Prominent journals folded, one by one, and were replaced with specialized publications dealing with genethics, reproethics, nanoethics, and necroethics. Mainstream bioethics organizations also collapsed, giving way to new associations along disciplinary and sub-disciplinary lines. Physicians established their own journals, and specialty groups broke away from more general associations of medical ethics. Lawyers also split into three separate factions, and philosophers rejected all but the most rigorous, analytic articles into their newly established journal. Matters finally came to a head with global warming, the world-wide spread of malaria and dengue, and the cost of medical treatments out of reach for almost everyone. The result was the need to develop plans for strict rationing of medical care. At the same time, recognition emerged of the importance of the right to health and the need for global justice in health. By 2060, a spark of hope was ignited, opening the door to the resuscitation of bioethics and involvement of the global community.

Discovery of New Hydrothermal Activity and Chemosynthetic Fauna on the Central Indian Ridge at 18°–20°S

PubMed Central

Nakamura, Kentaro; Watanabe, Hiromi; Miyazaki, Junichi; Takai, Ken; Kawagucci, Shinsuke; Noguchi, Takuro; Nemoto, Suguru; Watsuji, Tomo-o; Matsuzaki, Takuya; Shibuya, Takazo; Okamura, Kei; Mochizuki, Masashi; Orihashi, Yuji; Ura, Tamaki; Asada, Akira; Marie, Daniel; Koonjul, Meera; Singh, Manvendra; Beedessee, Girish; Bhikajee, Mitrasen; Tamaki, Kensaku

2012-01-01

Indian Ocean hydrothermal vents are believed to represent a novel biogeographic province, and are host to many novel genera and families of animals, potentially indigenous to Indian Ocean hydrothermal systems. In particular, since its discovery in 2001, much attention has been paid to a so-called ‘scaly-foot’ gastropod because of its unique iron-sulfide-coated dermal sclerites and the chemosynthetic symbioses in its various tissues. Despite increasing interest in the faunal assemblages at Indian Ocean hydrothermal vents, only two hydrothermal vent fields have been investigated in the Indian Ocean. Here we report two newly discovered hydrothermal vent fields, the Dodo and Solitaire fields, which are located in the Central Indian Ridge (CIR) segments 16 and 15, respectively. Chemosynthetic faunal communities at the Dodo field are emaciated in size and composition. In contrast, at the Solitaire field, we observed faunal communities that potentially contained almost all genera found at CIR hydrothermal environments to date, and even identified previously unreported taxa. Moreover, a new morphotype of ‘scaly-foot’ gastropod has been found at the Solitaire field. The newly discovered ‘scaly-foot’ gastropod has similar morphological and anatomical features to the previously reported type that inhabits the Kairei field, and both types of ‘scaly-foot’ gastropods genetically belong to the same species according to analyses of their COI gene and nuclear SSU rRNA gene sequences. However, the new morphotype completely lacks an iron-sulfide coating on the sclerites, which had been believed to be a novel feature restricted to ‘scaly-foot’ gastropods. Our new findings at the two newly discovered hydrothermal vent sites provide important insights into the biodiversity and biogeography of vent-endemic ecosystems in the Indian Ocean. PMID:22431990

EIT Crinkles as Evidence for the Breakout Model of Solar Eruptions

NASA Technical Reports Server (NTRS)

Sterling, Alphonse C.; Moore, Ronald L.

2001-01-01

We present observations of two homologous flares in NOAA Active Region 8210 occurring on 1998 May 1 and 2, using EUV data from the EUV Imaging Telescope (EIT) on board the Solar and Heliospheric Observatory, high-resolution and high-time cadence images from the soft X-ray telescope on Yohkoh, images or fluxes from the hard X-ray telescope on Yohkoh and the BATSE experiment on board the Compton Gamma Ray Observatory, and Ca(XIX) soft X-ray spectra from the Bragg crystal spectrometer (BCS) on Yohkoh. Magnetograms indicate that the flares occurred in a complex magnetic topology, consisting of an emerging flux region (EFR) sandwiched between a sunspot to the west and a coronal hole to the east. In an earlier study we found that in EIT images, both flaring episodes showed the formation of a crinkle-like pattern of emission (EIT crinkles) occurring in the coronal hole vicinity, well away from a central 'core field' area near the EFR-sunspot boundary. With our expanded data set, here we find that most of the energetic activity occurs in the core region in both events, with some portions of the core brightening shortly after the onset of the EIT crinkles, and other regions of the core brightening several minutes later, coincident with a burst of hard X-rays; there are no obvious core brightenings prior to the onset of the EIT crinkles. These timings are consistent with the 'breakout model' of solar eruptions, whereby the emerging flux is initially constrained by a system of overlying magnetic field lines, and is able to erupt only after an opening develops in the overlying fields as a consequence of magnetic reconnection at a magnetic null point. In our case, the EIT crinkles would be a signature of this pre-impulsive phase magnetic reconnection, and brightening of the core only occurs after the core fields begin to escape through the newly created opening in the overlying fields. Morphology in soft X-ray images and properties in hard X-rays differ between the two events, with complexities that preclude a simple determination of the dynamics in the core at the times of eruption. From the BCS spectra, we find that the core region expends energy at a rate of approximately 10(exp 26) ergs/s during the time of the growth of the EIT crinkles; this rate is an upper limit to energy expended in the reconnections opening the overlying fields. Energy losses occur at an order of magnitude higher rate near the time of the peak of the events. There is little evidence of asymmetry in the spectra, consistent with the majority of the mass flows occurring normal to the line of sight. Both events have similar electron temperature dependencies on time.

Behavioral and locomotor measurements using an open field activity monitoring system for skeletal muscle diseases.

PubMed

Tatem, Kathleen S; Quinn, James L; Phadke, Aditi; Yu, Qing; Gordish-Dressman, Heather; Nagaraju, Kanneboyina

2014-09-29

The open field activity monitoring system comprehensively assesses locomotor and behavioral activity levels of mice. It is a useful tool for assessing locomotive impairment in animal models of neuromuscular disease and efficacy of therapeutic drugs that may improve locomotion and/or muscle function. The open field activity measurement provides a different measure than muscle strength, which is commonly assessed by grip strength measurements. It can also show how drugs may affect other body systems as well when used with additional outcome measures. In addition, measures such as total distance traveled mirror the 6 min walk test, a clinical trial outcome measure. However, open field activity monitoring is also associated with significant challenges: Open field activity measurements vary according to animal strain, age, sex, and circadian rhythm. In addition, room temperature, humidity, lighting, noise, and even odor can affect assessment outcomes. Overall, this manuscript provides a well-tested and standardized open field activity SOP for preclinical trials in animal models of neuromuscular diseases. We provide a discussion of important considerations, typical results, data analysis, and detail the strengths and weaknesses of open field testing. In addition, we provide recommendations for optimal study design when using open field activity in a preclinical trial.

Multiphysics Modeling and Simulations of Mil A46100 Armor-Grade Martensitic Steel Gas Metal Arc Welding Process

NASA Astrophysics Data System (ADS)

Grujicic, M.; Ramaswami, S.; Snipes, J. S.; Yen, C.-F.; Cheeseman, B. A.; Montgomery, J. S.

2013-10-01

A multiphysics computational model has been developed for the conventional Gas Metal Arc Welding (GMAW) joining process and used to analyze butt-welding of MIL A46100, a prototypical high-hardness armor martensitic steel. The model consists of five distinct modules, each covering a specific aspect of the GMAW process, i.e., (a) dynamics of welding-gun behavior; (b) heat transfer from the electric arc and mass transfer from the electrode to the weld; (c) development of thermal and mechanical fields during the GMAW process; (d) the associated evolution and spatial distribution of the material microstructure throughout the weld region; and (e) the final spatial distribution of the as-welded material properties. To make the newly developed GMAW process model applicable to MIL A46100, the basic physical-metallurgy concepts and principles for this material have to be investigated and properly accounted for/modeled. The newly developed GMAW process model enables establishment of the relationship between the GMAW process parameters (e.g., open circuit voltage, welding current, electrode diameter, electrode-tip/weld distance, filler-metal feed speed, and gun travel speed), workpiece material chemistry, and the spatial distribution of as-welded material microstructure and properties. The predictions of the present GMAW model pertaining to the spatial distribution of the material microstructure and properties within the MIL A46100 weld region are found to be consistent with general expectations and prior observations.

Characterization and Analysis of a Multicolor Quantum Well Infrared Photodetector

DTIC Science & Technology

2006-06-01

and characterization of performance of a newly designed, multicolor quantum well infrared photodetector ( QWIP ). Specifically, it focuses on a detector...quantum well infrared detectors makes them suitable for use in the field. 15. NUMBER OF PAGES 67 14. SUBJECT TERMS Quantum Well, QWIP , Three...characterization of performance of a newly designed, multicolor quantum well infrared photodetector ( QWIP ). Specifically, it focuses on a detector

Observations of a Small Interplanetary Magnetic Flux Rope Opening by Interchange Reconnection

NASA Astrophysics Data System (ADS)

Wang, J. M.; Feng, H. Q.; Zhao, G. Q.

2018-01-01

Interchange reconnection, specifically magnetic reconnection between open magnetic fields and closed magnetic flux ropes, plays a major role in the heliospheric magnetic flux budget. It is generally accepted that closed magnetic field lines of interplanetary magnetic flux ropes (IMFRs) can gradually open through reconnection between one of its legs and other open field lines until no closed field lines are left to contribute flux to the heliosphere. In this paper, we report an IMFR associated with a magnetic reconnection exhaust, whereby its closed field lines were opening by a magnetic reconnection event near 1 au. The reconnection exhaust and the following IMFR were observed on 2002 February 2 by both the Wind and ACE spacecraft. Observations on counterstreaming suprathermal electrons revealed that most magnetic field lines of the IMFR were closed, especially those after the front boundary of the IMFR, with both ends connected to the Sun. The unidirectional suprathermal electron strahls before the exhaust manifested the magnetic field lines observed before the exhaust was open. These observations provide direct evidence that closed field lines of IMFRs can be opened by interchange reconnection in interplanetary space. This is the first report of the closed field lines of IMFRs being opened by interchange reconnection in interplanetary space. This type of interplanetary interchange reconnection may pose important implications for balancing the heliospheric flux budget.

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

EPA Science Inventory

Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deploy...

Time-Resolved Records of Magnetic Activity on the Pallasite Parent Body and Psyche

NASA Astrophysics Data System (ADS)

Bryson, J. F. J.; Nichols, C. I. O.; Herrero-Albillos, J.; Kronast, F.; Kasama, T.; Alimadadi, H.; van der Laan, G.; Nimmo, F.; Harrison, R. J.

2014-12-01

Although many small bodies apparently generated dynamo fields in the early solar system, the nature and temporal evolution of these fields has remained enigmatic. Time-resolved records of the Earth's planetary field have been essential in understanding the dynamic history of our planet, and equivalent information from asteroids could provide a unique insight into the development of the solar system. Here we present time-resolved records of magnetic activity on the main-group pallasite parent body and (16) Psyche, obtained using newly-developed nanomagnetic imaging techniques. For the pallasite parent body, the inferred field direction remained relatively constant and the intensity was initially stable at ~100 μT before it decreased in two discrete steps down to 0 μT. We interpret this behaviour as due to vigorous dynamo activity driven by compositional convection in the core, ultimately transitioning from a dipolar to multipolar field as the inner core grew from the bottom-up. For Psyche (measured from IVA iron meteorites), the inferred field direction reversed, while the intensity remained stable at >50 μT. Psyche cooled rapidly as an unmantled core, although the resulting thermal convection alone cannot explain these observations. Instead, this behaviour required top-down core solidification, and is attributed either to compositional convection (if the core also solidified from the bottom-up) or convection generated directly by top-down solidification (e.g. Fe-snow). The mechanism governing convection in small body cores is an open question (due partly to uncertainties in the direction of core solidification), and these observations suggest that unconventional (i.e. not thermal) mechanisms acted in the early solar system. These mechanisms are very efficient at generating convection, implying a long-lasting and widespread epoch of dynamo activity among small bodies in the early solar system.

`Shut The Front Door!':. Obviating the Challenge of Large-Scale Extra Dimensions and Psychophysical Bridging

NASA Astrophysics Data System (ADS)

Amoroso, Richard L.

2013-09-01

Physics has been slowly and reluctantly beginning to address the role and fundamental basis of the `observer' which has until now also been considered metaphysical and beyond the mandate of empirical rigor. It is suggested that the fundamental premise of the currently dominant view of `Cognitive Theory' - "Mind Equals Brain" is erroneous; and the associated belief that the `Planck scale, `the so-called basement level of reality', as an appropriate arena from which to model psycho-physical bridging is also in error. In this paper we delineate a simple, inexpensive experimental design to `crack the so-called cosmic egg' thereby opening the door to largescale extra dimensions (LSXD) tantamount to the regime of the unified field and thus awareness. The methodology surmounts the quantum uncertainty principle in a manner violating Quantum Electrodynamics, (QED), a cornerstone of modern theoretical physics, by spectrographic analysis of newly theorized Tight-Bound State (TBS) Bohr orbits in `continuous-state' transition frequencies of atomic hydrogen. If one wonders why QED violation in the spectra of atomic hydrogen relates to solving the mind-body (observer) problem; consider this a 1st wrench in a forthcoming tool box of Unified Field Mechanics, UF that will soon enough in retrospect cause the current tools of Classical and Quantum Mechanics to appear as stone axes. Max Planck is credited as the founder of quantum mechanics with his 1900 quantum hypothesis that energy is radiated and absorbed discretely by the formulation, E = hv. Empirically implementing this next paradigm shift utilizing parameters of the long sought associated `new physics' of the 3rd regime (classicalquantum- unified) allows access to LSXD of space; thus pragmatically opening the domain of mental action for the 1st time in history. This rendering constitutes a massive paradigm shift to Unified Field Theory creating a challenge for both the writer and the reader!

Streamer Evaporation

NASA Technical Reports Server (NTRS)

Suess, Steven T.; Wang, A. H.; Wu, Shi T.; Nerney, S.

1998-01-01

Evaporation is the consequence of slow plasma heating near the tops of streamers where the plasma is only weakly contained by the magnetic field. The form it takes is the slow opening of field lines at the top of the streamer and transient formation of new solar wind. It was discovered in polytropic model calculations, where due to the absence of other energy loss mechanisms in magnetostatic streamers, its ultimate endpoint is the complete evaporation of the streamer. This takes, for plausible heating rates, weeks to months in these models. Of course streamers do not behave this way, for more than one reason. One is that there are losses due to thermal conduction to the base of the streamer and radiation from the transition region. Another is that streamer heating must have a characteristic time constant and depend on the ambient physical conditions. We use our global Magnetohydrodynamics (MHD) model with thermal conduction to examine a few examples of the effect of changing the heating scale height and of making ad hoc choices for how the heating depends on ambient conditions. At the same time, we apply and extend the analytic model of streamers, which showed that streamers will be unable to contain plasma for temperatures near the cusp greater than about 2xl0(exp 6) K. Slow solar wind is observed to come from streamers through transient releases. A scenario for this that is consistent with the above physical process is that heating increases the near-cusp temperature until field lines there are forced open. The subsequent evacuation of the flux tubes by the newly forming slow wind decreases the temperature and heating until the flux tubes are able to reclose. Then, over a longer time scale, heating begins to again refill the flux tubes with plasma and increase the temperature until the cycle repeats itself. The calculations we report here are first steps towards quantitative evaluation of this scenario.

An active region filament studied simultaneously in the chromosphere and photosphere. I. Magnetic structure

NASA Astrophysics Data System (ADS)

Kuckein, C.; Martínez Pillet, V.; Centeno, R.

2012-03-01

Aims: A thorough multiwavelength, multiheight study of the vector magnetic field in a compact active region filament (NOAA 10781) on 2005 July 3 and 5 is presented. We suggest an evolutionary scenario for this filament. Methods: Two different inversion codes were used to analyze the full Stokes vectors acquired with the Tenerife Infrared Polarimeter (TIP-II) in a spectral range that comprises the chromospheric He i 10 830 Å multiplet and the photospheric Si i 10 827 Å line. In addition, we used SOHO/MDI magnetograms, as well as BBSO and TRACE images, to study the evolution of the filament and its active region (AR). High-resolution images of the Dutch Open Telescope were also used. Results: An active region filament (formed before our observing run) was detected in the chromospheric helium absorption images on July 3. The chromospheric vector magnetic field in this portion of the filament was strongly sheared (parallel to the filament axis), whereas the photospheric field lines underneath had an inverse polarity configuration. From July 3 to July 5, an opening and closing of the polarities on either side of the polarity inversion line (PIL) was recorded, resembling the recently discovered process of the sliding door effect seen by Hinode. This is confirmed with both TIP-II and SOHO/MDI data. During this time, a newly created region that contained pores and orphan penumbrae at the PIL was observed. On July 5, a normal polarity configuration was inferred from the chromospheric spectra, while strongly sheared field lines aligned with the PIL were found in the photosphere. In this same data set, the spine of the filament is also observed in a different portion of the field of view and is clearly mapped by the silicon line core. Conclusions: The inferred vector magnetic fields of the filament suggest a flux rope topology. Furthermore, the observations indicate that the filament is divided in two parts, one which lies in the chromosphere and another one that stays trapped in the photosphere. Therefore, only the top of the helical structure is seen by the helium lines. The pores and orphan penumbrae at the PIL appear to be the photospheric counterpart of the extremely low-lying filament. We suggest that orphan penumbrae are formed in very narrow PILs of compact ARs and are the photospheric manifestation of flux ropes in the photosphere.

Probing the physics of newly born magnetars through observation of superluminous supernovae

NASA Astrophysics Data System (ADS)

Cheng, Quan; Zhang, Shuang-Nan; Yu, Yun-Wei; Zheng, Xiao-Ping

2018-05-01

The central engines of some superluminous supernovae (SLSNe) are generally suggested to be newly born fast rotating magnetars, which spin down mainly through magnetic dipole radiation and gravitational wave emission. We calculate the magnetar-powered SLSNe light curves (LCs) with the tilt angle evolution of newly born magnetars involved. We show that, depending on the internal toroidal magnetic fields B¯t, the initial spin periods Pi, and the radii RDU of direct Urca (DU) cores of newly born magnetars, as well as the critical temperature Tc for 3P2 neutron superfluidity, bumps could appear in the SLSNe LCs after the maximum lights when the tilt angles grow to π /2 . The value of Tc determines the arising time and the relative amplitude of a bump. The quantity RDU can affect the arising time and the luminosity of a bump, as well as the peak luminosity of a LC. For newly born magnetars with dipole magnetic fields Bd=5 ×1014 G , B¯t=4.6 ×1016 G , and Pi=1 ms , there are no bumps in the LCs if Tc=2 ×109 K , or RDU=1.5 ×105 cm . Moreover, it is interesting that a stronger B¯t will lead to both a brighter peak and a brighter bump in a LC. While keeping other quantities unchanged, the bump in the LC disappears for the magnetar with smaller Pi. We suggest that, once the SLSNe LCs with such kinds of bumps are observed, by fitting these LCs with our model, not only Bd and Pi of newly born magnetars but also the crucial physical quantities B¯t, RDU, and Tc could be determined. Nonobservation of SLSNe LCs with such kinds of bumps hitherto may already put some (though very rough) constraints on B¯t, Pi, RDU, and Tc. Therefore, observation of SLSNe LCs may provide a new approach to probe the physics of newly born magnetars.

KSC-03PD-2210

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. This aerial view, looking northwest, shows the newly opened Space Commerce Way that winds from S.R 3 on the right to its exit on S.R. 405 (near the top) in the background. The road is the new public access from Merritt Island to the KSC Visitor Complex (seen at top).

Krikalev and Gidzenko at ISS hatch

NASA Image and Video Library

2001-02-10

ISS-01-E-5324 (10 February 2001) --- Cosmonauts Sergei K. Krikalev (left), Expedition One flight engineer, and Yuri P. Gidzenko, Soyuz commander, are pictured at the hatch that leads from the Unity node into the newly attached Destiny laboratory. The picture was recorded with a digital still camera on the day the hatch was initially opened.

Raise the Bar

ERIC Educational Resources Information Center

Williams, Dana

2004-01-01

Detroit's Benjamin Carson Academy (BCA) is believed to be the nation's first charter school for juvenile offenders. Opened in 1999, BCA is housed in the newly built Wayne County Juvenile Detention Facility, a state of the art, 89,300-square-foot building in downtown Detroit with half a dozen gymnasiums, two computer labs, a media center, mental…

78 FR 42805 - Nixon Presidential Historical Materials: Opening of Materials

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... Library in Yorba Linda. The newly released tapes will also be available on August 21, 2013 on the Web at... Nixon Presidential Historical Materials by the Richard Nixon Presidential Library and Museum, a division... required by law, including the PRMPA. DATES: The Richard Nixon Presidential Library and Museum intends to...

Pathway to a compact SASE FEL device

NASA Astrophysics Data System (ADS)

Dattoli, G.; Di Palma, E.; Petrillo, V.; Rau, Julietta V.; Sabia, E.; Spassovsky, I.; Biedron, S. G.; Einstein, J.; Milton, S. V.

2015-10-01

Newly developed high peak power lasers have opened the possibilities of driving coherent light sources operating with laser plasma accelerated beams and wave undulators. We speculate on the combination of these two concepts and show that the merging of the underlying technologies could lead to new and interesting possibilities to achieve truly compact, coherent radiator devices.

Education in the Anthropocene: Ethico-Moral Dimensions and Critical Realist Openings

ERIC Educational Resources Information Center

Olvitt, Lausanne Laura

2017-01-01

Human-induced changes in planetary bio-geo-chemical processes have tipped earth into a newly-proposed geological epoch: the Anthropocene, which places moral and ethical demands on people regarding who should take responsibility for the well-being of people and planet, how, and why. Drawing generally on critical realist ontology, and more…

Effects of rat sex differences and lighting on locomotor exploration of a circular open field with free-standing central corners and without peripheral walls.

PubMed

Alstott, Jeff; Timberlake, William

2009-01-23

A typical open field consists of a square enclosure, bounded by four straight walls joined by identical corners. For decades behavioral researchers have used the open center and more sheltered perimeter of such fields to examine the effects of drugs, sex differences, and illumination on the behavioral expression of fear and anxiety. The present study "reversed" the relative security of the center and periphery of a circular field to re-examine the functional relation of open field behavior to experience, sex differences and lighting. Across six daily exposures, males in both the light and dark rapidly increased their preference for the center. Females in the light developed a similar pattern, though more slowly; females in the dark continued to spend the great majority of their time in the open periphery, including the edge of the field. The behavior of all groups, but especially the dark females, strongly supports the continued importance of environmental assessment in open field behavior.

Incorporation of Student-Centered, Practical Applications of Geographic Information Systems to Raise Awareness and Generate Solutions for Local Environmental Issues

NASA Astrophysics Data System (ADS)

Bilsley, N. A.; Love, C. A.; Minster, J. B. H.

2014-12-01

Geographic Information Systems (GIS) offer a plethora of applications for numerous fields, from geological sciences to urban planning. Therefore, developing a practical GIS curriculum for students from a diverse selection of majors can be challenging, especially since time constraints presented by the course term limit the number of projects that can cater to each student's academic focus. However, open ended assignments that allow students the freedom to personalize their projects present an opportunity to teach the universal functionality of GIS, as well as stimulate curiosity of students from all backgrounds by allowing them to tailor a project to their personal interests. During an introductory GIS course at the University of California, San Diego, projects prompted students to utilize ArcGIS in ways of their choice that raised awareness of local environmental issues, as well as encouraged students to incorporate environmentally sustainable practices into their lives. In view of the frequently stated interest of students to enter careers where they can use their newly learned GIS skills, the educational platform of choice is ESRI's ArcGIS, but the choice of platform remains flexible. As GIS resources become more accessible with the development of programs such as OpenGIS and OpenStreetMap, the potential for GIS to effectively communicate environmental issues to the public is growing fast. Incorporating these environmental issues into a curriculum not only allows students to personalize their education, but also raises awareness of such problems and provides students with the ability to communicate those issues using GIS.

Genomics of Immune Diseases and New Therapies.

PubMed

Lenardo, Michael; Lo, Bernice; Lucas, Carrie L

2016-05-20

Genomic DNA sequencing technologies have been one of the great advances of the 21st century, having decreased in cost by seven orders of magnitude and opening up new fields of investigation throughout research and clinical medicine. Genomics coupled with biochemical investigation has allowed the molecular definition of a growing number of new genetic diseases that reveal new concepts of immune regulation. Also, defining the genetic pathogenesis of these diseases has led to improved diagnosis, prognosis, genetic counseling, and, most importantly, new therapies. We highlight the investigational journey from patient phenotype to treatment using the newly defined XMEN disease, caused by the genetic loss of the MAGT1 magnesium transporter, as an example. This disease illustrates how genomics yields new fundamental immunoregulatory insights as well as how research genomics is integrated into clinical immunology. At the end, we discuss two other recently described diseases, CHAI/LATAIE (CTLA-4 deficiency) and PASLI (PI3K dysregulation), as additional examples of the journey from unknown immunological diseases to new precision medicine treatments using genomics.

Cellular automata and its applications in protein bioinformatics.

PubMed

Xiao, Xuan; Wang, Pu; Chou, Kuo-Chen

2011-09-01

With the explosion of protein sequences generated in the postgenomic era, it is highly desirable to develop high-throughput tools for rapidly and reliably identifying various attributes of uncharacterized proteins based on their sequence information alone. The knowledge thus obtained can help us timely utilize these newly found protein sequences for both basic research and drug discovery. Many bioinformatics tools have been developed by means of machine learning methods. This review is focused on the applications of a new kind of science (cellular automata) in protein bioinformatics. A cellular automaton (CA) is an open, flexible and discrete dynamic model that holds enormous potentials in modeling complex systems, in spite of the simplicity of the model itself. Researchers, scientists and practitioners from different fields have utilized cellular automata for visualizing protein sequences, investigating their evolution processes, and predicting their various attributes. Owing to its impressive power, intuitiveness and relative simplicity, the CA approach has great potential for use as a tool for bioinformatics.

Scientific Software - the role of best practices and recommendations

NASA Astrophysics Data System (ADS)

Fritzsch, Bernadette; Bernstein, Erik; Castell, Wolfgang zu; Diesmann, Markus; Haas, Holger; Hammitzsch, Martin; Konrad, Uwe; Lähnemann, David; McHardy, Alice; Pampel, Heinz; Scheliga, Kaja; Schreiber, Andreas; Steglich, Dirk

2017-04-01

In Geosciences - like in most other communities - scientific work strongly depends on software. For big data analysis, existing (closed or open source) program packages are often mixed with newly developed codes. Different versions of software components and varying configurations can influence the result of data analysis. This often makes reproducibility of results and reuse of codes very difficult. Policies for publication and documentation of used and newly developed software, along with best practices, can help tackle this problem. Within the Helmholtz Association a Task Group "Access to and Re-use of scientific software" was implemented by the Open Science Working Group in 2016. The aim of the Task Group is to foster the discussion about scientific software in the Open Science context and to formulate recommendations for the production and publication of scientific software, ensuring open access to it. As a first step, a workshop gathered interested scientists from institutions across Germany. The workshop brought together various existing initiatives from different scientific communities to analyse current problems, share established best practices and come up with possible solutions. The subjects in the working groups covered a broad range of themes, including technical infrastructures, standards and quality assurance, citation of software and reproducibility. Initial recommendations are presented and discussed in the talk. They are the foundation for further discussions in the Helmholtz Association and the Priority Initiative "Digital Information" of the Alliance of Science Organisations in Germany. The talk aims to inform about the activities and to link with other initiatives on the national or international level.

Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats

PubMed Central

Glenn, Melissa J.; Kirby, Elizabeth D.; Gibson, Erin M.; Wong-Goodrich, Sarah; Mellott, Tiffany J.; Blusztajn, Jan K.; Williams, Christina L.

2008-01-01

Supplemental choline in the maternal diet produces a lasting enhancement in memory in offspring that resists age-related decline and is accompanied by neuroanatomical, neurophysiological and neurochemical changes in the hippocampus. The present study was designed to examine: 1) if prenatal choline supplementation alters behaviors that contribute to risk or resilience in cognitive aging, and 2) whether, at old age (25 months), prenatally choline supplemented rats show evidence of preserved hippocampal plasticity. A longitudinal design was used to look at exploration of an open field, with and without objects, at 1 and 24 months of age in male and female rats whose mothers were fed a diet supplemented with choline (SUP; 5 mg/kg choline chloride) or not supplemented (CON; 1.1 mg/kg choline chloride) on embryonic days 12–17. Aging caused a significant decline in open field exploration that was more pronounced in males but interest in novel objects was maintained in both sexes. Prenatal choline supplementation attenuated, but did not prevent age-related decline in exploration in males and increased object exploration in young females. Following behavioral assessment, rats were euthanized to assess markers of hippocampal plasticity. Aged SUP males and females had more newly proliferated cells in the hippocampal dentate gyrus and protein levels of vascular-endothelial growth factor (VEGF) and neurotrophin-3 (NT-3) were significantly elevated in female SUP rats in comparison to all other groups. Taken together, these findings provide the first evidence that prenatal cholinesupplementation causes changes in exploratory behaviors over the lifespan and preserves some features of hippocampal plasticity that can be seen even at 2 years of age. PMID:18786518

Ergonomic design and evaluation of new surgical scissors.

PubMed

Shimomura, Yoshihiro; Shirakawa, Hironori; Sekine, Masashi; Katsuura, Tetsuo; Igarashi, Tatsuo

2015-01-01

The purpose of this study is to design a new surgical scissors handle and determine its effectiveness with various usability indices. A new scissors handle was designed that retains the professional grip but has the shapes of the eye rings modified to fit the thumb and ring finger and finger rests for the index and little finger. The newly designed scissors and traditional scissors were compared by electromyography, subjective evaluation and task performance in experiments using cutting and peeling tasks. The newly designed scissors reduced muscle load in both hand during cutting by the closing action, and reduced the muscle load in the left hand during peeling by the opening action through active use of the right hand. In evaluation by surgeons, task performance improved in addition to the decrease in muscle load. The newly designed scissors used in this study demonstrated high usability. A new scissors handle was designed that has the eye rings modified to fit the thumb and ring finger. The newly designed scissors reduced muscle load and enabled active use of the right hand. In evaluation by surgeons, task performance improved in addition to the decrease in muscle load.

Catalog of particles and fields data 19581965

NASA Technical Reports Server (NTRS)

King, M. L. (Editor)

1975-01-01

Available particles and fields data, covering the period 1966 to 1973 inclusive, are announced. Most data result from individual experiments carried on board individual spacecraft. A variety of user-oriented data are included. A newly created composite interplanetary magnetic field data set is discussed and other data products, that may interest the particles/fields community are mentioned, including geomagnetism, magnetopause and bow shock positions, and magnetospherically trapped particles.

30 CFR 203.71 - How does MMS allocate a field's suspension volume between my lease and other leases on my field?

Code of Federal Regulations, 2010 CFR

2010-07-01

... relief by filing the short-form application specified in § 203.83 and authorized in § 203.82. An assigned... are evaluating your application In our evaluation of your authorized field, we will take into account... period for evaluation until you modify your application to be consistent with the newly constituted field...

High-resolution Topography of PACMANUS and DESMOS Hydrothermal Fields in the Manus Basin through ROV "FAXIAN"

NASA Astrophysics Data System (ADS)

Luan, Z.; Ma, X.; Yan, J.; Zhang, X.; Zheng, C.; Sun, D.

2016-12-01

High-resolution topography can help us deeply understand the seabed and related geological processes (e.g. hydrothermal/cold spring systems) in the deep sea areas. However, such studies are rare in China due to the limit of deep-sea detection technology. Here, we report the advances of the application of ROV in China and the newly measured high-resolution topographical data in PACMANUS and DESMOS hydrothermal fields. In June 2015, the ROV "FAXIAN" with a multibeam system (Kongsberg EM2040) was deployed to measure the topography of PACMANUS and DESMOS hydrothermal fields in the Manus basin. A composite positioning system on the ROV provided long baseline (LBL) navigation and positioning during measurements, giving a high positioning accuracy (better than 0.5m). The raw bathymetric data obtained were processed using CARIS HIPS (version 8.1). Based on the high-resolution data, we can describe the topographical details of the PACMANUS and DESMOS hydrothermal fields. High-resolution terrain clearly shows the detailed characters of the topography in the PACMANUS hydrothermal field, and some cones are corresponding to the pre discovered hydrothermal points and volcanic area. Most hydrothermal points in the PACMANUS hydrothermal field mainly developed on the steep slopes with a gradient exceeding 30 °. In contrast, the DESMOS field is a caldera that is approximately 250 m deep in the center with an E-W diameter of approximately1 km and a N-S diameter of approximately 2 km. The seafloor is much steeper on the inner side of the circular fracture. Two highlands occur in the northern and the southern flanks of the caldera. Video record indicated that pillow lava, sulfide talus, breccia, anhydrite, outcrops, and sediment all appeared in the DESMOS field. This is the first time for the ROV "FAXIAN" to be used in near-bottom topography measurements in the hydrothermal fields, opening a window of deep-sea researches in China.

Determination of space shuttle flow field by the three-dimensional method of characteristics

NASA Technical Reports Server (NTRS)

Chu, C.; Powers, S. A.

1972-01-01

The newly improved three-dimensional method of characteristics program has been applied successfully to the calculation of flow fields over a variety of bodies including slab delta wings and shuttle orbiters. Flow fields over fuselage shapes for Mach numbers as low as 1.5 have been calculated. Some typical results are presented.

Newly learned word forms are abstract and integrated immediately after acquisition

PubMed Central

Kapnoula, Efthymia C.; McMurray, Bob

2015-01-01

A hotly debated question in word learning concerns the conditions under which newly learned words compete or interfere with familiar words during spoken word recognition. This has recently been described as a key marker of the integration of a new word into the lexicon and was thought to require consolidation Dumay & Gaskell, (Psychological Science, 18, 35–39, 2007; Gaskell & Dumay, Cognition, 89, 105–132, 2003). Recently, however, Kapnoula, Packard, Gupta, and McMurray, (Cognition, 134, 85–99, 2015) showed that interference can be observed immediately after a word is first learned, implying very rapid integration of new words into the lexicon. It is an open question whether these kinds of effects derive from episodic traces of novel words or from more abstract and lexicalized representations. Here we addressed this question by testing inhibition for newly learned words using training and test stimuli presented in different talker voices. During training, participants were exposed to a set of nonwords spoken by a female speaker. Immediately after training, we assessed the ability of the novel word forms to inhibit familiar words, using a variant of the visual world paradigm. Crucially, the test items were produced by a male speaker. An analysis of fixations showed that even with a change in voice, newly learned words interfered with the recognition of similar known words. These findings show that lexical competition effects from newly learned words spread across different talker voices, which suggests that newly learned words can be sufficiently lexicalized, and abstract with respect to talker voice, without consolidation. PMID:26202702

Neurocognitive sparing of desktop microbeam irradiation.

PubMed

Bazyar, Soha; Inscoe, Christina R; Benefield, Thad; Zhang, Lei; Lu, Jianping; Zhou, Otto; Lee, Yueh Z

2017-08-11

Normal tissue toxicity is the dose-limiting side effect of radiotherapy. Spatial fractionation irradiation techniques, like microbeam radiotherapy (MRT), have shown promising results in sparing the normal brain tissue. Most MRT studies have been conducted at synchrotron facilities. With the aim to make this promising treatment more available, we have built the first desktop image-guided MRT device based on carbon nanotube x-ray technology. In the current study, our purpose was to evaluate the effects of MRT on the rodent normal brain tissue using our device and compare it with the effect of the integrated equivalent homogenous dose. Twenty-four, 8-week-old male C57BL/6 J mice were randomly assigned to three groups: MRT, broad-beam (BB) and sham. The hippocampal region was irradiated with two parallel microbeams in the MRT group (beam width = 300 μm, center-to-center = 900 μm, 160 kVp). The BB group received the equivalent integral dose in the same area of their brain. Rotarod, marble burying and open-field activity tests were done pre- and every month post-irradiation up until 8 months to evaluate the cognitive changes and potential irradiation side effects on normal brain tissue. The open-field activity test was substituted by Barnes maze test at 8th month. A multilevel model, random coefficients approach was used to evaluate the longitudinal and temporal differences among treatment groups. We found significant differences between BB group as compared to the microbeam-treated and sham mice in the number of buried marble and duration of the locomotion around the open-field arena than shams. Barnes maze revealed that BB mice had a lower capacity for spatial learning than MRT and shams. Mice in the BB group tend to gain weight at the slower pace than shams. No meaningful differences were found between MRT and sham up until 8-month follow-up using our measurements. Applying MRT with our newly developed prototype compact CNT-based image-guided MRT system utilizing the current irradiation protocol can better preserve the integrity of normal brain tissue. Consequently, it enables applying higher irradiation dose that promises better tumor control. Further studies are required to evaluate the full extent effects of this novel modality.

Evidence in Magnetic Clouds for Systematic Open Flux Transport on the Sun

NASA Technical Reports Server (NTRS)

Crooker, N. U.; Kahler, S. W.; Gosling, J. T.; Lepping, R. P.

2008-01-01

Most magnetic clouds encountered by spacecraft at 1 AU display a mix of unidirectional suprathermal electrons signaling open field lines and counterstreaming electrons signaling loops connected to the Sun at both ends. Assuming the open fields were originally loops that underwent interchange reconnection with open fields at the Sun, we determine the sense of connectedness of the open fields found in 72 of 97 magnetic clouds identified by the Wind spacecraft in order to obtain information on the location and sense of the reconnection and resulting flux transport at the Sun. The true polarity of the open fields in each magnetic cloud was determined from the direction of the suprathermal electron flow relative to the magnetic field direction. Results indicate that the polarity of all open fields within a given magnetic cloud is the same 89% of the time, implying that interchange reconnection at the Sun most often occurs in only one leg of a flux rope loop, thus transporting open flux in a single direction, from a coronal hole near that leg to the foot point of the opposite leg. This pattern is consistent with the view that interchange reconnection in coronal mass ejections systematically transports an amount of open flux sufficient to reverse the polarity of the heliospheric field through the course of the solar cycle. Using the same electron data, we also find that the fields encountered in magnetic clouds are only a third as likely to be locally inverted as not. While one might expect inversions to be equally as common as not in flux rope coils, consideration of the geometry of spacecraft trajectories relative to the modeled magnetic cloud axes leads us to conclude that the result is reasonable.

Energy buildup in sheared force-free magnetic fields

NASA Technical Reports Server (NTRS)

Wolfson, Richard; Low, Boon C.

1992-01-01

Photospheric displacement of the footpoints of solar magnetic field lines results in shearing and twisting of the field, and consequently in the buildup of electric currents and magnetic free energy in the corona. The sudden release of this free energy may be the origin of eruptive events like coronal mass ejections, prominence eruptions, and flares. An important question is whether such an energy release may be accompanied by the opening of magnetic field lines that were previously closed, for such open field lines can provide a route for matter frozen into the field to escape the sun altogether. This paper presents the results of numerical calculations showing that opening of the magnetic field is permitted energetically, in that it is possible to build up more free energy in a sheared, closed, force-free magnetic field than is in a related magnetic configuration having both closed and open field lines. Whether or not the closed force-free field attains enough energy to become partially open depends on the form of the shear profile; the results presented compare the energy buildup for different shear profiles. Implications for solar activity are discussed briefly.

Survey of viruses present in radish fields in 2014

USDA-ARS?s Scientific Manuscript database

In Korea, recent climate change has caused increased insect populations and migration from neighboring countries. As insect migration increases newly emerging virus diseases have been reported. In 2014, we performed a nationwide survey in radish fields to investigate the distribution of common virus...

Facilitating open global data use in earthquake source modelling to improve geodetic and seismological approaches

NASA Astrophysics Data System (ADS)

Sudhaus, Henriette; Heimann, Sebastian; Steinberg, Andreas; Isken, Marius; Vasyura-Bathke, Hannes

2017-04-01

In the last few years impressive achievements have been made in improving inferences about earthquake sources by using InSAR (Interferometric Synthetic Aperture Radar) data. Several factors aided these developments. The open data basis of earthquake observations has expanded vastly with the two powerful Sentinel-1 SAR sensors up in space. Increasing computer power allows processing of large data sets for more detailed source models. Moreover, data inversion approaches for earthquake source inferences are becoming more advanced. By now data error propagation is widely implemented and the estimation of model uncertainties is a regular feature of reported optimum earthquake source models. Also, more regularly InSAR-derived surface displacements and seismological waveforms are combined, which requires finite rupture models instead of point-source approximations and layered medium models instead of homogeneous half-spaces. In other words the disciplinary differences in geodetic and seismological earthquake source modelling shrink towards common source-medium descriptions and a source near-field/far-field data point of view. We explore and facilitate the combination of InSAR-derived near-field static surface displacement maps and dynamic far-field seismological waveform data for global earthquake source inferences. We join in the community efforts with the particular goal to improve crustal earthquake source inferences in generally not well instrumented areas, where often only the global backbone observations of earthquakes are available provided by seismological broadband sensor networks and, since recently, by Sentinel-1 SAR acquisitions. We present our work on modelling standards for the combination of static and dynamic surface displacements in the source's near-field and far-field, e.g. on data and prediction error estimations as well as model uncertainty estimation. Rectangular dislocations and moment-tensor point sources are exchanged by simple planar finite rupture models. 1d-layered medium models are implemented for both near- and far-field data predictions. A highlight of our approach is a weak dependence on earthquake bulletin information: hypocenter locations and source origin times are relatively free source model parameters. We present this harmonized source modelling environment based on example earthquake studies, e.g. the 2010 Haiti earthquake, the 2009 L'Aquila earthquake and others. We discuss the benefit of combined-data non-linear modelling on the resolution of first-order rupture parameters, e.g. location, size, orientation, mechanism, moment/slip and rupture propagation. The presented studies apply our newly developed software tools which build up on the open-source seismological software toolbox pyrocko (www.pyrocko.org) in the form of modules. We aim to facilitate a better exploitation of open global data sets for a wide community studying tectonics, but the tools are applicable also for a large range of regional to local earthquake studies. Our developments therefore ensure a large flexibility in the parametrization of medium models (e.g. 1d to 3d medium models), source models (e.g. explosion sources, full moment tensor sources, heterogeneous slip models, etc) and of the predicted data (e.g. (high-rate) GPS, strong motion, tilt). This work is conducted within the project "Bridging Geodesy and Seismology" (www.bridges.uni-kiel.de) funded by the German Research Foundation DFG through an Emmy-Noether grant.

Collection overview: ten years of wonderful open access science.

PubMed

Roberts, Roland G; Alfred, Jane

2013-10-01

To mark our tenth Anniversary at PLOS Biology, we are launching a special, celebratory Tenth Anniversary PLOS Biology Collection which showcases 10 specially selected PLOS Biology research articles drawn from a decade of publishing excellent science. It also features newly commissioned articles, including thought-provoking pieces on the Open Access movement (past and present), on article-level metrics, and on the history of the Public Library of Science. Each research article highlighted in the collection is also accompanied by a PLOS Biologue blog post to extend the impact of these remarkable studies to the widest possible audience.

Collection Overview: Ten Years of Wonderful Open Access Science

PubMed Central

Roberts, Roland G.; Alfred, Jane

2013-01-01

To mark our tenth Anniversary at PLOS Biology, we are launching a special, celebratory Tenth Anniversary PLOS Biology Collection which showcases 10 specially selected PLOS Biology research articles drawn from a decade of publishing excellent science. It also features newly commissioned articles, including thought-provoking pieces on the Open Access movement (past and present), on article-level metrics, and on the history of the Public Library of Science. Each research article highlighted in the collection is also accompanied by a PLOS Biologue blog post to extend the impact of these remarkable studies to the widest possible audience. PMID:24167446

Stress and stressors in the clinical environment: a comparative study of fourth-year student nurses and newly qualified general nurses in Ireland.

PubMed

Suresh, Patricia; Matthews, Anne; Coyne, Imelda

2013-03-01

To measure and compare the perceived levels of job-related stress and stressors of newly qualified nurses and fourth-year student nurses in the clinical environment and to explore the participants' views on stress and stressors. Stress in the nursing workplace has significant consequences for the person, the patient and the organisation, such as psychological and physical health deterioration and impaired professional practice. To address this problem, stress and stressors need to be measured and identified. This study used a cross-sectional survey design and self-reporting questionnaires to measure and compare levels of stress in both groups. Convenience sampling involved all newly qualified nurses (n = 120) and fourth-year student nurses (n = 128) in Dublin North-East region in Ireland. The instrument used was 'The Nursing Stress Scale' (Gray-Toft & Anderson 1981, Journal of Behavioral Assessment 3, 11-23). Descriptive, qualitative analysis was conducted on an open-ended question. Data were obtained from newly qualified nurses (n = 31) and fourth-year student nurses (n = 40) in six acute hospital sites. Levels of perceived stress and stressors were high in both groups. Themes identified from the responses to the open question by both groups included excessive workload, difficult working relationships and unmet clinical learning needs. Student nurses also reported the combination of academic demands with clinical placement as a major stressor. There was no significant difference between each group. Stress continues to be a problem for nurses in the clinical setting. Excessive workload requires urgent attention by hospital managers in view of widespread retention difficulties. Themes identified could provide a framework for possible interventions for improving the clinical environment for nurses. These results can help stakeholders in nurse education and practice to develop interventions to reduce stress for both groups and to ease the transition from student to graduate nurse. © 2012 Blackwell Publishing Ltd.

Characteristics of Ambient Black Carbon Mass and Size-Resolved Particle Number Concentrations during Corn Straw Open-Field Burning Episode Observations at a Rural Site in Southern Taiwan.

PubMed

Cheng, Yu-Hsiang; Yang, Li-Sing

2016-07-08

Information on the effect of open-field burning of agricultural residues on ambient black carbon (BC) mass and size-resolved particle number concentrations is scarce. In this study, to understand the effect of such open-field burning on short-term air quality, real-time variations of the BC mass and size-resolved particle number concentrations were monitored before and during a corn straw open-field burning episode at a rural site. Correlations between the BC mass and size-resolved particle number concentrations during the episode were investigated. Moreover, the particle number size distribution and absorption Ångström exponent were determined for obtaining the characteristics of aerosol emissions from the corn straw open-field burning. The results can be used to address public health concerns and as a reference for managing similar episodes of open-field burning of agricultural residues.

Observations of disconnection of open coronal magnetic structures

NASA Technical Reports Server (NTRS)

Mccomas, D. J.; Phillips, J. L.; Hundhausen, A. J.; Burkepile, J. T.

1991-01-01

The solar maximum mission coronagraph/polarimeter observations are surveyed for evidence of magnetic disconnection of previously open magnetic structures and several sequences of images consistent with this interpretation are identified. Such disconnection occurs when open field lines above helmet streamers reconnect, in contrast to previously suggested disconnections of CMEs into closed plasmoids. In this paper a clear example of open field disconnection is shown in detail. The event, on June 27, 1988, is preceded by compression of a preexisting helmet streamer and the open coronal field around it. The compressed helmet streamer and surrounding open field region detach in a large U-shaped structure which subsequently accelerates outward from the sun. The observed sequence of events is consistent with reconnection across the heliospheric current sheet and the creation of a detached U-shaped magnetic structure. Unlike CMEs, which may open new magnetic flux into interplanetary space, this process could serve to close off previously open flux, perhaps helping to maintain the roughly constant amount of open magnetic flux observed in interplanetary space.

Exploring the extremely low surface brightness sky: distances to 23 newly discovered objects in Dragonfly fields

NASA Astrophysics Data System (ADS)

van Dokkum, Pieter

2016-10-01

We are obtaining deep, wide field images of nearby galaxies with the Dragonfly Telephoto Array. This telescope is optimized for low surface brightness imaging, and we are finding many low surface brightness objects in the Dragonfly fields. In Cycle 22 we obtained ACS imaging for 7 galaxies that we had discovered in a Dragonfly image of the galaxy M101. Unexpectedly, the ACS data show that only 3 of the galaxies are members of the M101 group, and the other 4 are very large Ultra Diffuse Galaxies (UDGs) at much greater distance. Building on our Cycle 22 program, here we request ACS imaging for 23 newly discovered low surface brightness objects in four Dragonfly fields centered on the galaxies NGC 1052, NGC 1084, NGC 3384, and NGC 4258. The immediate goals are to construct the satellite luminosity functions in these four fields and to constrain the number density of UDGs that are not in rich clusters. More generally, this complete sample of extremely low surface brightness objects provides the first systematic insight into galaxies whose brightness peaks at >25 mag/arcsec^2.

Interchange Reconnection and Coronal Hole Dynamics

NASA Technical Reports Server (NTRS)

Edmondson, J. K.; Antiochos, S. K.; DeVore, C. R.; Lynch, B. J.; Zurbuchen, T. H.

2011-01-01

We investigate the effect of magnetic reconnection between open and closed field, (often referred to as "interchange" reconnection), on the dynamics and topology of coronal hole boundaries. The most important and most prevalent 3D topology of the interchange process is that of a small-scale bipolar magnetic field interacting with a large-scale background field. We determine the evolution of such a magnetic topology by numerical solution of the fully 3D MHD equations in spherical coordinates. First, we calculate the evolution of a small-scale bipole that initially is completely inside an open field region and then is driven across a coronal hole boundary by photospheric motions. Next the reverse situation is calculated in which the bipole is initially inside the closed region and driven toward the coronal hole boundary. In both cases we find that the stress imparted by the photospheric motions results in deformation of the separatrix surface between the closed field of the bipole and the background field, leading to rapid current sheet formation and to efficient reconnection. When the bipole is inside the open field region, the reconnection is of the interchange type in that it exchanges open and closed field. We examine, in detail, the topology of the field as the bipole moves across the coronal hole boundary, and find that the field remains well-connected throughout this process. Our results imply that open flux cannot penetrate deeply into the closed field region below a helmet streamer and, hence, support the quasi-steady models in which open and closed flux remain topologically distinct. Our results also support the uniqueness hypothesis for open field regions as postulated by Antiochos et al. We discuss the implications of this work for coronal observations. Subject Headings: Sun: corona Sun: magnetic fields Sun: reconnection Sun: coronal hole

Higher Education: Open for Business

ERIC Educational Resources Information Center

Gilde, Christian, Ed.

2007-01-01

This book addresses a problem in higher learning, which is newly recognized in the academic spotlight: the overcommercialization of higher education. The book asks that you, the reader, think about the following: Did you go to a Coke or Pepsi school? Do your children attend a Nike or Adidas school? Is the college in your town a Dell or Gateway…

Making Science Meaningful for Young People with Diverse Needs

ERIC Educational Resources Information Center

Stead, Di

2015-01-01

In the autumn term of 2011, it was identified that a programme of support for developing science in the curriculum was required at a newly opened special school, Beacon Reach, in Lancashire, which caters to children with autism spectrum disorders. Staff wanted to provide a relevant and meaningful curriculum, accessible even to young people who…

Current Piano Education of Turkish Music Teacher Candidates: Comparisons of Instructors and Students Perceptions

ERIC Educational Resources Information Center

Jelen, Birsen

2015-01-01

In recent years almost every newly opened government funded university in Turkey has established a music department where future music teachers are educated and piano is compulsory for every single music teacher candidate in Turkey. The aim of this research is to compare piano teaching instructors' and their students' perceptions about the current…

Characteristics of plasmids in multi-drug-resistant enterobacteriaceae isolated during prospective surveillance of a newly opened hospital in Iraq

USDA-ARS?s Scientific Manuscript database

Multidrug-resistant (MDR) bacteria such as Escherichia coli and Klebsiella spp. are increasingly common causes of infections in hospitals worldwide and also in the U.S. military treatment facilities. Plasmids are thought to play an important role in the dissemination of antibiotic resistance in thes...

Governance and Foreign Aid Allocation

DTIC Science & Technology

2006-07-01

the promotion of market-based principles to restructure macroeconomic policies in developing countries. The greater focus on...the effectiveness of aid in promoting development outcomes. In doing so, I use augmented neoclassical growth framework following Mankiw et al (1992...health care and basic education, macroeconomic reforms and opening markets, the main objective of western foreign aid was to stop newly independent

Genome Sequence of JangDynasty, a Newly Isolated Mycobacteriophage

PubMed Central

Jang, Casey; Kalaj, Nancy; Hwang, Brian; Hughes, Lorelei; Yang, Connie; Pak, Thomas; Kim, John; Han, Dong Yoon; Tedjakusnadi, Jason; Fernandez, Nicholas; Dean, Natasha; Muthiah, Arun; Sutter, Nathaniel B.

2018-01-01

ABSTRACT JangDynasty is a bacteriophage that infects Mycobacterium smegmatis mc2155. It has a genome length of 70,883 bp, with 124 predicted open reading frames (ORFs), 42 of which have known functions. JangDynasty belongs to cluster O, and like other cluster O phages, it is a siphovirus with a prolate capsid. PMID:29798914

Proactive interference of open field on consummatory successive negative contrast.

PubMed

Justel, Nadia; Pautassi, Ricardo; Mustaca, Alba

2014-03-01

Reactivity to a reward is affected by prior experience with the different reinforcer values of that reward, a phenomenon known as incentive relativity, which can be studied using the consummatory succesive negative contrast (cSNC) paradigm, in which the performance of animals that receive a 4 % sucrose solution after trials on which they were exposed to 32 % sucrose is compared with that of subjects that always receive the 4 % sucrose solution. The exploration of a novel open field can enhance or block the acquisition of associative and nonassociative memories. The effect of open field on cSNC has not yet been explored. The main result of the present study was that open-field exposure significantly modified the expression of cSNC. Exposure to an open field 1 h but not immediately before the downshift interfered with the expression of cSNC. These animals drank more of the downshifted reward than did controls that were not exposed to the apparatus, and this behavior persisted for up to three recovery trials. This phenomenon was observed even when the animals were given a more protracted preshift phase and when the discrepancy between the preshift and shift incentive values of sucrose were increased. An open field also interfered with incentive downshift when open-field exposure occurred 6 h before the downshift, and repeated exposure to the apparatus did not deteriorate this effect. The present study adds to a growing body of literature that indicates that open-field exploration can interfere with memory formation.

Induced Voltage in an Open Wire

NASA Astrophysics Data System (ADS)

Morawetz, K.; Gilbert, M.; Trupp, A.

2017-07-01

A puzzle arising from Faraday's law has been considered and solved concerning the question which voltage will be induced in an open wire with a time-varying homogeneous magnetic field. In contrast to closed wires where the voltage is determined by the time variance of the magnetic field and the enclosed area, in an open wire we have to integrate the electric field along the wire. It is found that the longitudinal electric field with respect to the wave vector contributes with 1/3 and the transverse field with 2/3 to the induced voltage. In order to find the electric fields the sources of the magnetic fields are necessary to know. The representation of a spatially homogeneous and time-varying magnetic field implies unavoidably a certain symmetry point or symmetry line which depend on the geometry of the source. As a consequence the induced voltage of an open wire is found to be the area covered with respect to this symmetry line or point perpendicular to the magnetic field. This in turn allows to find the symmetry points of a magnetic field source by measuring the voltage of an open wire placed with different angles in the magnetic field. We present exactly solvable models of the Maxwell equations for a symmetry point and for a symmetry line, respectively. The results are applicable to open circuit problems like corrosion and for astrophysical applications.

Can Polar Fields Explain Missing Open Flux?

NASA Astrophysics Data System (ADS)

Linker, J.; Downs, C.; Caplan, R. M.; Riley, P.; Mikic, Z.; Lionello, R.

2017-12-01

The "open" magnetic field is the portion of the Sun's magnetic field that extends out into the heliosphere and becomes the interplanetary magnetic field (IMF). Both the IMF and the Sun's magnetic field in the photosphere have been measured for many years. In the standard paradigm of coronal structure, the open magnetic field originates primarily in coronal holes. The regions that are magnetically closed trap the coronal plasma and give rise to the streamer belt. This basic picture is qualitatively reproduced by models of coronal structure using photospheric magnetic fields as input. If this paradigm is correct, there are two primary observational constraints on the models: (1) The open field regions in the model should approximately correspond to coronal holes observed in emission, and (2) the magnitude of the open magnetic flux in the model should match that inferred from in situ spacecraft measurements. Linker et al. (2017, ApJ, submitted) investigated the July 2010 time period for a range of observatory maps and both PFSS and MHD models. We found that all of the model/map combinations underestimated the interplanetary magnetic flux, unless the modeled open field regions were larger than observed coronal holes. An estimate of the open magnetic flux made entirely from solar observations (combining detected coronal hole boundaries with observatory synoptic magnetic maps) also underestimated the interplanetary magnetic flux. The magnetic field near the Sun's poles is poorly observed and may not be well represented in observatory maps. In this paper, we explore whether an underestimate of the polar magnetic flux during this time period could account for the overall underestimate of open magnetic flux. Research supported by NASA, AFOSR, and NSF.

Topological defects in open string field theory

NASA Astrophysics Data System (ADS)

Kojita, Toshiko; Maccaferri, Carlo; Masuda, Toru; Schnabl, Martin

2018-04-01

We show how conformal field theory topological defects can relate solutions of open string field theory for different boundary conditions. To this end we generalize the results of Graham and Watts to include the action of defects on boundary condition changing fields. Special care is devoted to the general case when nontrivial multiplicities arise upon defect action. Surprisingly the fusion algebra of defects is realized on open string fields only up to a (star algebra) isomorphism.

Selected Characteristics of Newly Hired Faculty in New Jersey Public Colleges and Universities: Fall 1984-Fall 1985. Chancellor Report to the Board of Higher Education, February 1987.

ERIC Educational Resources Information Center

Chen, May K. C.

Information on newly hired faculty in New Jersey public colleges for fall 1984 and fall 1985 is presented, including degrees held, academic rank, and teaching fields. Data are provided for the state colleges, community colleges, Rutgers University, the New Jersey Institute of Technology, and the University of Medicine and Dentistry of New Jersey…

A comparison of three approaches for simulating fine-scale surface winds in support of wildland fire management: Part I. Model formulation and comparison against measurements

Treesearch

Jason M. Forthofer; Bret W. Butler; Natalie S. Wagenbrenner

2014-01-01

For this study three types of wind models have been defined for simulating surface wind flow in support of wildland fire management: (1) a uniform wind field (typically acquired from coarse-resolution (,4 km) weather service forecast models); (2) a newly developed mass-conserving model and (3) a newly developed mass and momentumconserving model (referred to as the...

Nature of Kinetic Scale Fluctuations in Solar Wind Turbulence

NASA Astrophysics Data System (ADS)

Salem, C. S.; Chen, C. H.; Sundkvist, D. J.; Chaston, C. C.; Bale, S. D.; Mozer, F.

2012-12-01

We present an investigation of the nature of small-scale turbulent fluctuations in the solar wind. The nature of the dissipation range fluctuations of solar wind turbulence remains a major open question in heliospheric physics. The steepening of the observed (magnetic field) spectra at ion scales was originally attributed to ion cyclotron damping, but it was later suggested that it could well be due to the dispersive nature of fluctuations at these scales. The nature of the dispersive cascade at and below the ion scales is still debated, two leading hypothesis being that these fluctuations have characteristics of Kinetic Alfven Waves (KAW) or whistler waves. Other possible contributions from current sheets and/or kinetic instabilities have been suggested. There is mounting evidence that the fluctuations at these scales are KAW-like. In this study, we analyze several carefully selected unperturbed solar wind intervals, using magnetic field, electric field as well as density measurements from the Cluster spacecraft in order to identify the nature of the wave modes present, how frequent they are and try to determine whether one or more wave modes at different times. We examine the electric to magnetic field fluctuation ratio (δ E/δd B), the magnetic compressibility (δ B∥ /δ B) as well as density fluctuations using newly developed diagnostic techniques by Salem et al (2012) and Chen et al (2012). We look for variations of the nature and properties of these kinetic scale fluctuations with solar wind conditions, such as the plasma beta and the angle between the magnetic field and the flow velocity which controls the measured (spacecraft frame) frequency of the fluctuations. We discuss how these results would impact how the solar wind plasma is heated.

Correlation between local glaucomatous visual field defects and loss of nerve fiber layer thickness measured with polarimetry and spectral domain OCT.

PubMed

Horn, Folkert K; Mardin, Christian Y; Laemmer, Robert; Baleanu, Delia; Juenemann, Anselm M; Kruse, Friedrich E; Tornow, Ralf P

2009-05-01

To study the correlation between local perimetric field defects and glaucoma-induced thickness reduction of the nerve layer measured in the peripapillary area with scanning laser polarimetry (SLP) and spectral domain optical coherence tomography (SOCT) and to compare the results with those of a theoretical model. The thickness of the retinal nerve fiber layer was determined in 32 sectors (11.25 degrees each) by using SLP with variable cornea compensation (GDxVCC; Laser Diagnostics, San Diego, CA) and the newly introduced high-resolution SOCT (Spectralis; Heidelberg Engineering, Heidelberg, Germany). Eighty-eight healthy subjects served as control subjects, to determine the thickness deviation in patients with glaucoma. The relationship between glaucomatous nerve fiber reduction and visual field losses was calculated in six nerve fiber bundle-related areas. Sixty-four patients at different stages of open-angle glaucoma and 26 patients with ocular hypertension underwent perimetry (Octopus G1; Haag-Streit, Köniz, Switzerland) and measurements with the two morphometric techniques. Sector-shaped analyses between local perimetric losses and reduction of the retinal nerve fiber layer thickness showed a significant association for corresponding areas except for the central visual field in SLP. Correlation coefficients were highest in the area of the nasal inferior visual field (SOCT, -0.81; SLP, -0.57). A linear model describes the association between structural and functional damage. Localized perimetric defects can be explained by reduced nerve fiber layer thickness. The data indicate that the present SOCT is useful for determining the functional-structural relationship in peripapillary areas and that association between perimetric defects and corresponding nerve fiber losses is stronger for SOCT than for the present SLP. (ClinicalTrials.gov number, NCT00494923.).

Design and production of stopper made of concrete foam composite used for open channel conduit cover and parking bumper

NASA Astrophysics Data System (ADS)

Syam, Bustami; Sebayang, Alexander; Sebayang, Septian; Muttaqin, Maraghi; Darmadi, Harry; Basuki, WS; Sabri, M.; Abda, S.

2018-03-01

Open channel conduit is designed and produced with the aims to reduce excess water, whether from rain, seepage, or excess irrigation water in an area. It is also included in one of the important components of urban infrastructure in tackling the problem of flooding and waterlogging. On the roadway, e.g. housing complex the open channel conduits should function the same, however conduit covers are needed. The covers should be also designed to function as parking bumper. This paper discusses the design and production of the stoppers using our newly invented materials; the stoppers are structurally tested under static, dynamic, and bump test. Response of the conduit cover are found from structural analysis using finite element software ANSYS MECHANICAL version 17.5. Two types of stoppers are introduced: flat and curvy configuration. It was obtained that both types are suitable for open channel conduit cover and parking bumper.

Modelling of Operative Report Documents for Data Integration into an openEHR-Based Enterprise Data Warehouse.

PubMed

Haarbrandt, Birger; Wilschko, Andreas; Marschollek, Michael

2016-01-01

In order to integrate operative report documents from two operating room management systems into a data warehouse, we investigated the application of the two-level modelling approach of openEHR to create a shared data model. Based on the systems' analyses, a template consisting of 13 archetypes has been developed. Of these 13 archetypes, 3 have been obtained from the international archetype repository of the openEHR foundation. The remaining 10 archetypes have been newly created. The template was evaluated by an application system expert and through conducting a first test mapping of real-world data from one of the systems. The evaluation showed that by using the two-level modelling approach of openEHR, we succeeded to represent an integrated and shared information model for operative report documents. More research is needed to learn about the limitations of this approach in other data integration scenarios.

Velocity and size of droplets in dense region of diesel fuel spray on transient needle opening condition

NASA Astrophysics Data System (ADS)

Ueki, Hironobu; Ishida, Masahiro; Sakaguchi, Daisaku

2005-06-01

In order to investigate the effect of transient needle opening on early stage of spray behavior, simultaneous measurements of velocity and size of droplet were conducted by a newly developed laser 2-focus velocimeter (L2F). The micro-scale probe of the L2F was consisted of two foci with a distance of 36 µm. The tested nozzle had a single hole with a diameter of 0.2 mm. The measurements of injection pressure, needle lift, and crank angle were synchronized with the spray measurement by the L2F at the position 10 mm downstream from the nozzle exit. It has been clearly shown that the velocity and size of droplet increase with needle valve opening and that the probability density distribution of droplet size can be fitted to the Nukiyama-Tanasawa distribution under the transient needle opening condition.

Hypersonic simulations using open-source CFD and DSMC solvers

NASA Astrophysics Data System (ADS)

Casseau, V.; Scanlon, T. J.; John, B.; Emerson, D. R.; Brown, R. E.

2016-11-01

Hypersonic hybrid hydrodynamic-molecular gas flow solvers are required to satisfy the two essential requirements of any high-speed reacting code, these being physical accuracy and computational efficiency. The James Weir Fluids Laboratory at the University of Strathclyde is currently developing an open-source hybrid code which will eventually reconcile the direct simulation Monte-Carlo method, making use of the OpenFOAM application called dsmcFoam, and the newly coded open-source two-temperature computational fluid dynamics solver named hy2Foam. In conjunction with employing the CVDV chemistry-vibration model in hy2Foam, novel use is made of the QK rates in a CFD solver. In this paper, further testing is performed, in particular with the CFD solver, to ensure its efficacy before considering more advanced test cases. The hy2Foam and dsmcFoam codes have shown to compare reasonably well, thus providing a useful basis for other codes to compare against.

Open architectures for formal reasoning and deductive technologies for software development

NASA Technical Reports Server (NTRS)

Mccarthy, John; Manna, Zohar; Mason, Ian; Pnueli, Amir; Talcott, Carolyn; Waldinger, Richard

1994-01-01

The objective of this project is to develop an open architecture for formal reasoning systems. One goal is to provide a framework with a clear semantic basis for specification and instantiation of generic components; construction of complex systems by interconnecting components; and for making incremental improvements and tailoring to specific applications. Another goal is to develop methods for specifying component interfaces and interactions to facilitate use of existing and newly built systems as 'off the shelf' components, thus helping bridge the gap between producers and consumers of reasoning systems. In this report we summarize results in several areas: our data base of reasoning systems; a theory of binding structures; a theory of components of open systems; a framework for specifying components of open reasoning system; and an analysis of the integration of rewriting and linear arithmetic modules in Boyer-Moore using the above framework.

Effects of supervision on tax compliance: Evidence from a field experiment in Austria.

PubMed

Gangl, Katharina; Torgler, Benno; Kirchler, Erich; Hofmann, Eva

2014-06-01

We conduct a field experiment on tax compliance, focusing on newly founded firms. As a novelty the effect of tax authorities' supervision on timely tax payments is examined. Interestingly, results show no positive overall effect of close supervision on tax compliance.

Mouth-opening device as a treatment modality in trismus patients with head and neck cancer and oral submucous fibrosis: a prospective study.

PubMed

Li, Yu-Hsuan; Chang, Wei-Chin; Chiang, Tien-En; Lin, Chiun-Shu; Chen, Yuan-Wu

2018-04-26

This study investigated the clinical effectiveness of intervention with an open-mouth exercise device designed to facilitate maximal interincisal opening (MIO) and improve quality of life in patients with head and neck (H&N) cancer and oral submucous fibrosis (OSF). Sixty patients with H&N cancer, OSF, and trismus (MIO < 35 mm) participated in the functional rehabilitation program. An open-mouth exercise device intervention group and conventional group, each consisting of 20 patients, underwent a 12-week training and exercising program and follow-up. For the control group, an additional 20 patients were randomly selected to match the demographic characteristics of the aforementioned two groups. The patients' MIO improvements in the aforementioned three groups were 14.0, 10.5, and 1.3 mm, respectively. Results of this study confirm the significant improvement in average mouth-opening range. In addition, according to patient feedback, significant improvements in health-related quality of life and reductions in trismus symptoms occurred in the open-mouth exercise device group. This newly designed open-mouth exercise device can facilitate trismus patients with H&N cancer and OSF and improve mouth-opening range and quality of life.

A PERIPHERAL CHOLINERGIC PATHWAY MODULATES STRESS-INDUCED HYPERTHERMIA IN THE RAT EXPOSED TO AN OPEN FIELD.

EPA Science Inventory

Exposure to an open-field is psychologically stressful and leads to an elevation in core temperature (Tc). This increase in Tc associated with open-field is usually referred to as stress-induced hyperthermia (SIH) and can be blocked centrally with cyclooxygenase inhibitors suc...

Scaling law in free walking of mice in circular open fields of various diameters.

PubMed

Shoji, Hiroto

2016-03-01

Open-field tests are routinely used to study locomotor activity in rodents. I studied the effects of apparatus size on rodent locomotor activity, specifically with respect to how resting and walking periods are interwoven. I explored the open-field behavior of mice utilizing circular open fields of various diameters. When the diameter of the test apparatus was greater than 75 cm, the durations of the resting and moving periods of free walking behavior obeyed bounded power-law distribution functions. I found that the properties of the scaling exponents and model selection became similar for test apparatus diameters greater than 75 cm. These results can provide a guide for the selection of the size of the test apparatus for use in the study of the open-field behavior of rodents.

Enriched Open Field Facilitates Exercise and Social Interaction in 2 Strains of Guinea Pigs (Cavia porcellus)

PubMed Central

Brewer, Jacob S; Bellinger, Seanceray A; Joshi, Prianca; Kleven, Gale A

2014-01-01

Current housing guidelines for laboratory rodents include recommendations for enrichment. Working with guinea pigs, we have developed an open-field enrichment paradigm that provides several aspects of this species’ natural environment. These naturalistic aspects include access to increased space for exploration, access to western timothy (Phleum pratense L.) hay, and grouping as a herd to facilitate social interaction. To determine the immediate effect on behavior from access to the enriched environment, female guinea pigs from 2 strains, IAF Hairless and NIH Hartley, were observed in both standard home cages and an open-field enriched environment. Subjects were housed with cagemates in pairs for the home-cage observation and were grouped as a herd when in the open-field arena. Behaviors were videorecorded for 1 h and then scored. Salivary cortisol levels were measured both prior to and immediately after behavioral observations. Analyses revealed higher levels of activity and social interaction in the open-field arena compared with the home cage, with no significant change in salivary cortisol levels. These results suggest that exposure to the open-field environment provide increased opportunities for exercise and social enrichment. Although additional studies are needed to determine long-term effects on experimental outcomes, the open-field configuration holds promise as a laboratory enrichment paradigm for guinea pigs. PMID:25199089

Dissipation and enantioselective degradation of plant growth retardants paclobutrazol and uniconazole in open field, greenhouse, and laboratory soils.

PubMed

Wu, Chengwang; Sun, Jianqiang; Zhang, Anping; Liu, Weiping

2013-01-15

Greenhouses are increasingly important in human food supply. Pesticides used in greenhouses play important roles in horticulture; however, little is known about their behavior in greenhouse environments. This work investigates the dissipation and enantioselctive degradation of plant growth retardants including paclobutrazol and uniconazole in soils under three conditions (i.e., open field, greenhouse, and laboratory). The dissipation and enantioselective degradation of paclobutrazol and uniconazole in greenhouse were different from those in open field; they were more persistent in greenhouse than in open field soil. Leaching produced by rainfall is responsible for the difference in dissipation. Thus, local environmental impacts may occur more easily inside greenhouses, while groundwater may be more contaminated in open field. Spike concentrations of 5, 10, and 20 times the concentrations of native residues were tested for the enantioselective dissipation of the two pesticides; the most potent enantioselective degradation of paclobutrazol and uniconazole occurred at the 10 times that of the native residues in the greenhouse environments and at 20 times native residues in open field environments. The higher soil activity in greenhouses than in open fields was thought to be responsible for such a difference. The environmental risk and regulation of paclobutrazol and uniconazole should be considered at the enantiomeric level.

Enriched open field facilitates exercise and social interaction in 2 strains of guinea pigs (Cavia porcellus).

PubMed

Brewer, Jacob S; Bellinger, Seanceray A; Joshi, Prianca; Kleven, Gale A

2014-07-01

Current housing guidelines for laboratory rodents include recommendations for enrichment. Working with guinea pigs, we have developed an open-field enrichment paradigm that provides several aspects of this species' natural environment. These naturalistic aspects include access to increased space for exploration, access to western timothy (Phleum pratense L.) hay, and grouping as a herd to facilitate social interaction. To determine the immediate effect on behavior from access to the enriched environment, female guinea pigs from 2 strains, IAF Hairless and NIH Hartley, were observed in both standard home cages and an open-field enriched environment. Subjects were housed with cagemates in pairs for the home-cage observation and were grouped as a herd when in the open-field arena. Behaviors were videorecorded for 1 h and then scored. Salivary cortisol levels were measured both prior to and immediately after behavioral observations. Analyses revealed higher levels of activity and social interaction in the open-field arena compared with the home cage, with no significant change in salivary cortisol levels. These results suggest that exposure to the open-field environment provide increased opportunities for exercise and social enrichment. Although additional studies are needed to determine long-term effects on experimental outcomes, the open-field configuration holds promise as a laboratory enrichment paradigm for guinea pigs.

Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats.

PubMed

Shaw, D; Annett, J M; Doherty, B; Leslie, J C

2007-09-01

To establish a valid animal model of the effects of olfactory stimuli on anxiety, a series of experiments was conducted using rats in an open-field test. Throughout, effects of lavender oil were compared with the effects of chlordiazepoxide (CDP), as a reference anxiolytic with well-known effects on open-field behaviour. Rats were exposed to lavender oil (0.1-1.0 ml) for 30 min (Experiment 1) or 1h (Experiment 2) prior to open-field test and in the open field or injected with CDP (10 mg/kg i.p.). CDP had predicted effects on behaviour, and the higher doses of lavender oil had some effects on behaviour similar to those of CDP. In Experiment 3, various combinations of pre-exposure times and amounts of lavender oil were used. With sufficient exposure time and quantity of lavender the same effects were obtained as in Experiment 2. Experiment 4 demonstrated that these behavioural effects of lavender could be obtained following pre-exposure, even if no oil was present in the open-field test. In Experiments 2-4, lavender oil increased immobility. Together, these experiments suggest that lavender oil does have anxiolytic effects in the open field, but that a sedative effect can also occur at the highest doses.

Solar Field Optical Characterization at Stillwater Geothermal/Solar Hybrid Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Guangdong; Turchi, Craig

Concentrating solar power (CSP) can provide additional thermal energy to boost geothermal plant power generation. For a newly constructed solar field at a geothermal power plant site, it is critical to properly characterize its performance so that the prediction of thermal power generation can be derived to develop an optimum operating strategy for a hybrid system. In the past, laboratory characterization of a solar collector has often extended into the solar field performance model and has been used to predict the actual solar field performance, disregarding realistic impacting factors. In this work, an extensive measurement on mirror slope error andmore » receiver position error has been performed in the field by using the optical characterization tool called Distant Observer (DO). Combining a solar reflectance sampling procedure, a newly developed solar characterization program called FirstOPTIC and public software for annual performance modeling called System Advisor Model (SAM), a comprehensive solar field optical characterization has been conducted, thus allowing for an informed prediction of solar field annual performance. The paper illustrates this detailed solar field optical characterization procedure and demonstrates how the results help to quantify an appropriate tracking-correction strategy to improve solar field performance. In particular, it is found that an appropriate tracking-offset algorithm can improve the solar field performance by about 15%. The work here provides a valuable reference for the growing CSP industry.« less

Solar Field Optical Characterization at Stillwater Geothermal/Solar Hybrid Plant

DOE PAGES

Zhu, Guangdong; Turchi, Craig

2017-01-27

Concentrating solar power (CSP) can provide additional thermal energy to boost geothermal plant power generation. For a newly constructed solar field at a geothermal power plant site, it is critical to properly characterize its performance so that the prediction of thermal power generation can be derived to develop an optimum operating strategy for a hybrid system. In the past, laboratory characterization of a solar collector has often extended into the solar field performance model and has been used to predict the actual solar field performance, disregarding realistic impacting factors. In this work, an extensive measurement on mirror slope error andmore » receiver position error has been performed in the field by using the optical characterization tool called Distant Observer (DO). Combining a solar reflectance sampling procedure, a newly developed solar characterization program called FirstOPTIC and public software for annual performance modeling called System Advisor Model (SAM), a comprehensive solar field optical characterization has been conducted, thus allowing for an informed prediction of solar field annual performance. The paper illustrates this detailed solar field optical characterization procedure and demonstrates how the results help to quantify an appropriate tracking-correction strategy to improve solar field performance. In particular, it is found that an appropriate tracking-offset algorithm can improve the solar field performance by about 15%. The work here provides a valuable reference for the growing CSP industry.« less

Social instability stress in adolescence increases anxiety and reduces social interactions in adulthood in male Long-Evans rats.

PubMed

Green, Matthew R; Barnes, Brittany; McCormick, Cheryl M

2013-12-01

We investigated the effects of social instability stress (daily 1-hr isolation, change of cage partner, postnatal day 30-45) in adolescence in male rats on open field exploration and social behavior in adulthood. Social stressed rats had longer latencies to enter the center of an open field and then took longer to approach an object placed in the center of the field. When another rat was placed in the open field, stressed rats spent less time in social interaction than control rats, particularly when paired with another stressed, rather than a control, rat. The groups did not differ in social approach tests (when a stimulus rat was separated by wire mesh) nor in novel object exploration (when controlling for open field anxiety). The results suggest social stress in adolescence increases open field anxiety while maintaining exploratory behavior, and alters social interactions in adulthood. © 2012 Wiley Periodicals, Inc.

Direct Observation of Accretion onto a Hypernova's Newly Formed Black Hole

NASA Astrophysics Data System (ADS)

Milisavljevic, Dan

2017-09-01

Models of energetic core-collapse supernovae and long-duration gamma-ray bursts often invoke engine-driven scenarios associated with the formation of compact objects that input energy into the explosion. To date, only indirect evidence of black holes or magnetars formed in these events exists from observations obtained when the explosions are most luminous. Here we request a modest 15 ks Chandra pilot observation of the exceptionally important nearby hypernova SN2002ap to test models that predict X-ray emission associated with its remnant black hole to be detectable after 15 yr of ejecta expansion. Direct observation a newly formed "baby" black hole would be a landmark discovery capable of opening up new ways to investigate fundamental aspects of the core collapse process.

Effects of supervision on tax compliance: Evidence from a field experiment in Austria

PubMed Central

Gangl, Katharina; Torgler, Benno; Kirchler, Erich; Hofmann, Eva

2014-01-01

We conduct a field experiment on tax compliance, focusing on newly founded firms. As a novelty the effect of tax authorities’ supervision on timely tax payments is examined. Interestingly, results show no positive overall effect of close supervision on tax compliance. PMID:25843992

Psychology as Field Experience: Impact on Attitudes Toward Social Interventions.

ERIC Educational Resources Information Center

Snellman, Lynn A.; And Others

An innovation in the teaching of undergraduate psychology courses is the implementation of a field experience that gives students the opportunity to apply newly learned skills and knowledge in a community setting. Changes in undergraduates' attitudes toward various delinquency interventions were examined as a result of participation in a…

Apollo 1 Tribute Opening

NASA Image and Video Library

2017-01-27

Guests observe the gateway of the newly opened Apollo 1 tribute at the Apollo/Saturn V Center at NASA's Kennedy Space Center opened Jan. 27, 2017. Astronauts Gus Grissom, Ed White II and Chaffee perished in a fire at the launch pad on Jan. 27, 1967, during training for the mission. The tribute highlights the lives and careers of the astronauts. The tribute features numerous items recalling the lives of the three astronauts. The tribute also includes the three-part hatch to the spacecraft itself, the first time any part of the Apollo 1 spacecraft has been displayed publicly. A version of the hatch after it was redesigned is also showcased as an example of improvements NASA made throughout the agency and to the Apollo spacecraft that would later carry astronauts to the moon.

Apollo 1 Tribute Opening

NASA Image and Video Library

2017-01-27

Guests observe areas of the newly opened Apollo 1 tribute at the Apollo/Saturn V Center at NASA's Kennedy Space Center opened Jan. 27, 2017. Astronauts Gus Grissom, Ed White II and Chaffee perished in a fire at the launch pad on Jan. 27, 1967, during training for the mission. The tribute highlights the lives and careers of the astronauts. The tribute features numerous items recalling the lives of the three astronauts. The tribute also includes the three-part hatch to the spacecraft itself, the first time any part of the Apollo 1 spacecraft has been displayed publicly. A version of the hatch after it was redesigned is also showcased as an example of improvements NASA made throughout the agency and to the Apollo spacecraft that would later carry astronauts to the moon.

Apollo 1 Tribute Opening

NASA Image and Video Library

2017-01-27

Lowell Grissom, brother of Gus Grissom, observes areas of the newly opened Apollo 1 tribute at the Apollo/Saturn V Center at NASA's Kennedy Space Center opened Jan. 27, 2017. Astronauts Gus Grissom, Ed White II and Chaffee perished in a fire at the launch pad on Jan. 27, 1967, during training for the mission. The tribute highlights the lives and careers of the astronauts. The tribute features numerous items recalling the lives of the three astronauts. The tribute also includes the three-part hatch to the spacecraft itself, the first time any part of the Apollo 1 spacecraft has been displayed publicly. A version of the hatch after it was redesigned is also showcased as an example of improvements NASA made throughout the agency and to the Apollo spacecraft that would later carry astronauts to the moon.

Generalizations of γ-open set in topological spaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhattacharya, Baby, E-mail: babybhatt75@gmail.com; Paul, Arnab, E-mail: mrarnabpaul87@gmail.com

The main aim of this work is to study three generalized forms of γ-open set due to D. Andrijevic (D. Andrijevic, On the Topology Generated by pre-open sets, Presented at the Sixth Prague Topological Symposium, 39 (1987), 367-376)in a topological space. Out of which the dual appearance of one is the stronger form of b-locally closed set in the sense of Arafa A. Nasef (A. A Nasef,On b-locally closed sets and related topics, CHAOS SOLITONS & FRACTALS 12(2001) 1909-1915). Also, we introduce the concept of different types of continuity and study their basic properties by using these newly defined sets.more » Finally, we establish the interrelationships among themselves together with some already existing generalized forms of continuity.« less

Management of whitefly-transmitted viruses in open-field production systems

USDA-ARS?s Scientific Manuscript database

Whiteflies are a key pest of crops in open field production throughout the tropics and subtropics. This is due in large part to the long and diverse list of devastating plant viruses transmitted by these vectors. Open field production provides many challenges to manage these viruses and in many case...

Characterization of the Newly Developed Soybean Cultivar DT2008 in Relation to the Model Variety W82 Reveals a New Genetic Resource for Comparative and Functional Genomics for Improved Drought Tolerance

PubMed Central

Ha, Chien Van; Le, Dung Tien; Nishiyama, Rie; Watanabe, Yasuko; Tran, Uyen Thi; Dong, Nguyen Van; Tran, Lam-Son Phan

2013-01-01

Soybean (Glycine max) productivity is adversely affected by drought stress worldwide, including Vietnam. In the last few years, we have made a great effort in the development of drought-tolerant soybean cultivars by breeding and/or radiation-induced mutagenesis. One of the newly developed cultivars, the DT2008, showed enhanced drought tolerance and stable yield in the field conditions. The purpose of this study was to compare the drought-tolerant phenotype of DT2008 and Williams 82 (W82) by assessing their water loss and growth rate under dehydration and/or drought stress conditions as a means to provide genetic resources for further comparative and functional genomics. We found that DT2008 had reduced water loss under both dehydration and drought stresses in comparison with W82. The examination of root and shoot growths of DT2008 and W82 under both normal and drought conditions indicated that DT2008 maintains a better shoot and root growth rates than W82 under both two growth conditions. These results together suggest that DT2008 has better drought tolerance degree than W82. Our results open the way for further comparison of DT2008 and W82 at molecular levels by advanced omic approaches to identify mutation(s) involved in the enhancement of drought tolerance of DT2008, contributing to our understanding of drought tolerance mechanisms in soybean. Mutation(s) identified are potential candidates for genetic engineering of elite soybean varieties to improve drought tolerance and biomass. PMID:23509774

The free energies of partially open coronal magnetic fields

NASA Technical Reports Server (NTRS)

Low, B. C.; Smith, D. F.

1993-01-01

A simple model of the low corona is examined in terms of a static polytropic atmosphere in equilibrium with a global magnetic field. The question posed is whether magnetostatic states with partially open magnetic fields may contain magnetic energies in excess of those in fully open magnetic fields. Based on the analysis presented here, it is concluded that the cross-field electric currents in the pre-eruption corona are a viable source of the bulk of the energies in a mass ejection and its associated flare.

The relation between open-field and emergence tests in a hyperactive mouse model.

PubMed

Lalonde, R; Strazielle, C

2009-12-01

The relation between open-field and emergence tests was examined in mice with idiopathic hypertension. Spontaneous hypertensive mice (SHM) crossed more segments and reared more often in the open-field than normotensive controls at both age levels. In contrast, grooming episodes decreased only in the older SHM cohort. While young SHM emerged more quickly from a toy object only partially, complete emergence was faster only in the older SHM cohort. In the entire series, open-field segments were inversely correlated with 2- and 4-paw emergence latencies. There was also an inverse correlation between rears and 2-paw emergence but a positive correlation between grooming episodes and both types of emergence. In view of its association with open-field activity, the emergence test may have value in screening potential ADHD therapies.

EIT Crinkles as Evidence for the Breakout Model of Solar Eruptions

NASA Technical Reports Server (NTRS)

Sterling, Alphonse C.; Moore, R. L.; Whitaker, Ann F. (Technical Monitor)

2001-01-01

We present observations of two homologous flares in NOAA active region 8210 occurring on 1998 May 1 and May 2, using EUV data from the Extreme Ultraviolet Radiation Imaging Telescope (EIT) on the Solar and Heliospheric Observatory (SOHO), high-resolution and high-time cadence images from the soft X-ray telescope (SXT) on Yohkoh, images or fluxes from the hard X-ray telescope (HXT) on Yohkoh and the BATSE experiment on the Compton Gamma Ray Observatory (CGRO), and Ca xix soft X-ray spectra from the Bragg crystal spectrometer (BCS) on Yohkoh. Magnetograms indicate that the flares occurred in a complex magnetic topology, consisting of an emerging flux region (EFR) sandwiched between a sunspot to the west and a coronal hole to the east. In an earlier study we found that in EIT images, both flaring episodes showed the formation of a crinkle-like pattern of emission ("EIT crinkles") occurring in the coronal hole vicinity, well away from a central "core field" area near the EFR-sunspot boundary. With our expanded data set, here we find that most of the energetic activity occurs in the core region in both events, with some portions of the core brightening shortly after the onset of the EIT crinkles, and other regions of the core brightening several minutes later, coincident with a burst of hard X-rays: there are no obvious core brightenings prior to the onset of the EIT crinkles. These timings are consistent with the "breakout model" of solar eruptions, whereby the emerging flux is initially constrained by a system of overlying magnetic field lines, and is able to erupt only after an opening develops in the overlying fields as a consequence of magnetic reconnection at a magnetic null point. In our case, the EIT crinkles would be a signature of this pre-impulsive-phase magnetic reconnection, and brightening of the core only occurs after the core fields begin to escape through the newly-created opening in the overlying fields. Morphology in soft X-ray images and properties in hard X-rays differ between the two events, with complexities that preclude a simple determination of the dynamics in the core at the times of eruption. From the BCS spectra, we find that the core region expends energy at a rate of approx. 10(exp 26) erg per second during the time of the growth of the EIT crinkles; this rate is an upper limit to energy expended in the reconnections opening the overlying fields. Energy losses occur at an order-of-magnitude higher rate near the time of the peak of the events. There is little evidence of asymmetry in the spectra, consistent with the majority of the mass flows occurring normal to the line-of-sight. Both events have similar electron temperature dependencies on time.

Variation in damage from growing-season frosts among open-pollinated families of red alder.

Treesearch

Kevin C. Peeler; Dean S. DeBell

1987-01-01

Repeated growing-season frosts during late April and early May 1985 caused extensive damage to red alder (Alnus rubra Bong.) seedlings in a newly planted research trial in western Washington. About two-thirds of the seedlings were severely damaged (entire stem damaged or necrotic). Such damage varied by family, from 50 percent of seedlings in the...

Creative Exercises (CEs) in the Biochemistry Domain: An Analysis of Students' Linking of Chemical and Biochemical Concepts

ERIC Educational Resources Information Center

Warfa, Abdi-Rizak M.; Odowa, N.

2015-01-01

Creative exercises (CEs), a specific form of open-ended assessment tools, have been shown to promote students' linking of prior and newly learned concepts within a course. In this study, we examined how often students in an upper-division undergraduate biochemistry course linked prior chemical concepts to biochemical ones in response to CE…

An In-Law Comes To Stay: Examination of Interdisciplinary Conflict in a School-Based Health Center.

ERIC Educational Resources Information Center

Fast, Jonathan D.

2003-01-01

Social workers often work in settings where other professions exert a higher level of control. The organizational literature on causes of conflict and conflict resolution is briefly reviewed. A case study of a newly opened school-based health center provides an opportunity to analyze conflicts between the school and health center personnel and…

Corbell PTA's Wild Walk: Fundraiser Cultivates Community

ERIC Educational Resources Information Center

Cassano, Michelle

2012-01-01

When Corbell Elementary opened its doors in 2006 in Frisco, Texas, its newly formed PTA faced the challenge of implementing a productive fundraiser to get the school off to a great start. The new board chose to focus its efforts on a single fundraiser, rather than a series of smaller ones. They wanted to avoid having the children selling any kind…

A case study of hospital operations management.

PubMed

Cheng, T C

1987-12-01

This paper discusses a study to investigate various operations management problems in a newly opened, modern regional hospital in Hong Kong. The findings of the study reveal that there exist in the hospital a number of current and potential problem areas. Recommendations for solving these problems are suggested with a view to improving the overall operational efficiency and effectiveness of the hospital.

Genome Sequence of JangDynasty, a Newly Isolated Mycobacteriophage.

PubMed

Jang, Casey; Kalaj, Nancy; Hwang, Brian; Hughes, Lorelei; Yang, Connie; Pak, Thomas; Kim, John; Han, Dong Yoon; Tedjakusnadi, Jason; Fernandez, Nicholas; Dean, Natasha; Muthiah, Arun; Sutter, Nathaniel B; Diaz, Arturo

2018-05-24

JangDynasty is a bacteriophage that infects Mycobacterium smegmatis mc 2 155. It has a genome length of 70,883 bp, with 124 predicted open reading frames (ORFs), 42 of which have known functions. JangDynasty belongs to cluster O, and like other cluster O phages, it is a siphovirus with a prolate capsid. Copyright © 2018 Jang et al.

U.S. Department of Defense Official Website - World War II Memorial

Science.gov Websites

- The newly opened World War II Memorial on the National Mall in Washington, D.C., was dedicated May 29 . It honors the 16 million who served in the armed forces of the United States during World War II, the ;greatest generation." Defense Department photo illustration by Navy Lt. Cmdr. Jane Campbell World War

Education, Employment and School Religious Denomination in Scotland in the 1950s

ERIC Educational Resources Information Center

Paterson, Lindsay; Calvin, Catherine; Deary, Ian J.

2015-01-01

Newly available survey data allow the investigation of the educational and employment opportunities open to Roman Catholics in Scotland in the mid-20th century. Previous research has shown that Catholic disadvantage in education and the labour market in the early 20th century had weakened or vanished by the end of the century, and that the main…

Professional Development that Defies the Formal Construct of Teacher Learning: A Charter School's Commencement

ERIC Educational Resources Information Center

Oliver, Rollia Mandrell

2012-01-01

In August 2006, in accordance with a recently passed charter school law, a Mid-Atlantic school district opened its first public charter schools. The charter schools' staff had opportunities to exercise autonomy over their instruction and had very little in-service training. This study examined what seven teachers at a newly created charter school…

Disruption of coronal magnetic field arcades

NASA Technical Reports Server (NTRS)

Mikic, Zoran; Linker, Jon A.

1994-01-01

The ideal and resistive properties of isolated large-scale coronal magnetic arcades are studied using axisymmetric solutions of the time-dependent magnetohydrodynamic (MHD) equations in spherical geometry. We examine how flares and coronal mass ejections may be initiated by sudden disruptions of the magnetic field. The evolution of coronal arcades in response to applied shearing photospheric flows indicates that disruptive behavior can occur beyond a critical shear. The disruption can be traced to ideal MHD magnetic nonequilibrium. The magnetic field expands outward in a process that opens the field lines and produces a tangential discontinuity in the magnetic field. In the presence of plasma resistivity, the resulting current sheet is the site of rapid reconnection, leading to an impulsive release of magnetic energy, fast flows, and the ejection of a plasmoid. We relate these results to previous studies of force-free fields and to the properties of the open-field configuration. We show that the field lines in an arcade are forced open when the magnetic energy approaches (but is still below) the open-field energy, creating a partially open field in which most of the field lines extend away from the solar surface. Preliminary application of this model to helmet streamers indicates that it is relevant to the initiation of coronal mass ejections.

A hybrid analytical model for open-circuit field calculation of multilayer interior permanent magnet machines

NASA Astrophysics Data System (ADS)

Zhang, Zhen; Xia, Changliang; Yan, Yan; Geng, Qiang; Shi, Tingna

2017-08-01

Due to the complicated rotor structure and nonlinear saturation of rotor bridges, it is difficult to build a fast and accurate analytical field calculation model for multilayer interior permanent magnet (IPM) machines. In this paper, a hybrid analytical model suitable for the open-circuit field calculation of multilayer IPM machines is proposed by coupling the magnetic equivalent circuit (MEC) method and the subdomain technique. In the proposed analytical model, the rotor magnetic field is calculated by the MEC method based on the Kirchhoff's law, while the field in the stator slot, slot opening and air-gap is calculated by subdomain technique based on the Maxwell's equation. To solve the whole field distribution of the multilayer IPM machines, the coupled boundary conditions on the rotor surface are deduced for the coupling of the rotor MEC and the analytical field distribution of the stator slot, slot opening and air-gap. The hybrid analytical model can be used to calculate the open-circuit air-gap field distribution, back electromotive force (EMF) and cogging torque of multilayer IPM machines. Compared with finite element analysis (FEA), it has the advantages of faster modeling, less computation source occupying and shorter time consuming, and meanwhile achieves the approximate accuracy. The analytical model is helpful and applicable for the open-circuit field calculation of multilayer IPM machines with any size and pole/slot number combination.

[OPEN FIELD BEHAVIOR AS A PREDICTIVE CRITERIA REFLECTING RATS CORTICOSTERONELEVEL BEFORE AND AFTER STRESS].

PubMed

Umriukhin, P E; Grigorchuk, O S

2015-12-01

In the presented study we investigated the possibility to use the open field behavior data for prediction of corticosterone level in rat blood plasma before and after stress. It is shown that the most reliable open field behavior parameters, reflecting high probability of significant upregulation of corticosterone after 3 hours of immobilization, are the short latency of first movement and low locomotor activity during the test. Rats with high corticosterone at normal non-stress conditions are characterized by low locomotor activity and on the contrary long latency period for the entrance of open field center.

Designing Leadership and Soft Skills in Educational Games: The e-Leadership and Soft Skills Educational Games Design Model (ELESS)

ERIC Educational Resources Information Center

Freitas, Sara; Routledge, Helen

2013-01-01

While the field of leadership studies includes a large corpus of literature and studies, the literature and scientific research in the field of e-leadership and soft skills used in learning game environments are at present small in scale. Towards contributing to this newly emerging field of literature and study, this research paper presents a new…

How Much Flux does a Flux Transfer Event Transfer?

NASA Astrophysics Data System (ADS)

Fear, R. C.; Trenchi, L.; Coxon, J.; Milan, S. E.

2016-12-01

Flux transfer events are bursts of reconnection at the dayside magnetopause, which give rise to characteristic signatures that are observed by a range of magnetospheric/ionospheric instrumentation. Spacecraft situated near the magnetopause observe a bipolar variation in the component of the magnetic field normal to the magnetopause (BN); auroral instrumentation (either ground- or space-based) observe poleward moving auroral forms which indicate the convection of newly-opened flux into the polar cap, and ionospheric radars similarly observe pulsed ionospheric flows or poleward moving radar auroral forms. One outstanding problem is the fact that there is a fundamental mismatch between the estimates of the flux that is opened by each flux transfer event - in other words, their overall significance in the Dungey cycle. Spacecraft-based estimates of the flux content of individual FTEs correspond to each event transferring flux equivalent to approximately 1% of the open flux in the magnetosphere, whereas studies based on global-scale radar and auroral observations suggest this figure could be more like 10%. In the former case, flux transfer events would be a minor detail in the Dungey cycle, but in the latter they could be its main driver. We present observations of a conjunction between flux transfer event signatures observed by the Cluster spacecraft, and pulsed ionospheric flows observed by the SuperDARN network on the 8th February 2002. Over the course of an hour, a similar number of FTE signatures were observed by Cluster (at 13 MLT) and the Prince George radar (at 7 MLT). We argue that the reason for the existing mismatch in flux estimates is that implicit assumptions about flux transfer event structure lead to a major underestimate of the flux content based on spacecraft observations. If these assumptions are removed, a much better match is found.

Cohort profile: the German ClinSurv HIV project--a multicentre open clinical cohort study supplementing national HIV surveillance.

PubMed

Bätzing-Feigenbaum, J; Kollan, C; Kühne, A; Matysiak-Klose, D; Gunsenheimer-Bartmeyer, B; Hamouda, O

2011-05-01

New forms of HIV/AIDS therapy require new surveillance instruments to meet shifting public health demands. The Clinical Surveillance of HIV Disease (ClinSurv HIV) project was established in 1999 as a collaboration between major HIV treatment centres in Germany and the Robert Koch Institute (RKI). The project contributes to national HIV surveillance and focuses on the changing epidemiology of HIV/AIDS after the introduction of new therapies in 1995. ClinSurv HIV is designed as an open multicentre observational cohort study of HIV-infected patients. Anonymized data on diagnoses, treatment and laboratory parameters are collected in a standardized format. Data are currently sampled biannually via 11 centres specializing in HIV diagnosis and care within the legal framework of the German Protection against Infection Act [Infektionsschutzgesetz (IfSG)]. A total of 14874 patients were enrolled in the study by 30 June 2009. Of these, 10221 patients (68.7%) were enrolled after 1 January 1999 and 6006 patients (40.4%) were known to have been diagnosed as positive for HIV before 1999. Evaluation indicators, such as the number of newly enrolled patients per half-year period, loss to follow-up, completeness of data per case, availability of data per possible clinical contact, and internal quality control parameters, show a very stable evolution in the cohort, which although open, can be observed. Comparison with the national HIV surveillance data suggests a high degree of representativeness according to major demographic variables. Bearing in mind the obvious strengths and weaknesses discussed, the German ClinSurv HIV cohort provides a broad range of research opportunities in the field of HIV/AIDS both within Germany and in international collaborative research.

CHARMM additive and polarizable force fields for biophysics and computer-aided drug design

PubMed Central

Vanommeslaeghe, K.

2014-01-01

Background Molecular Mechanics (MM) is the method of choice for computational studies of biomolecular systems owing to its modest computational cost, which makes it possible to routinely perform molecular dynamics (MD) simulations on chemical systems of biophysical and biomedical relevance. Scope of Review As one of the main factors limiting the accuracy of MD results is the empirical force field used, the present paper offers a review of recent developments in the CHARMM additive force field, one of the most popular bimolecular force fields. Additionally, we present a detailed discussion of the CHARMM Drude polarizable force field, anticipating a growth in the importance and utilization of polarizable force fields in the near future. Throughout the discussion emphasis is placed on the force fields’ parametrization philosophy and methodology. Major Conclusions Recent improvements in the CHARMM additive force field are mostly related to newly found weaknesses in the previous generation of additive force fields. Beyond the additive approximation is the newly available CHARMM Drude polarizable force field, which allows for MD simulations of up to 1 microsecond on proteins, DNA, lipids and carbohydrates. General Significance Addressing the limitations ensures the reliability of the new CHARMM36 additive force field for the types of calculations that are presently coming into routine computational reach while the availability of the Drude polarizable force fields offers a model that is an inherently more accurate model of the underlying physical forces driving macromolecular structures and dynamics. PMID:25149274

Magnetar giant flares in multipolar magnetic fields. I. Fully and partially open eruptions of flux ropes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Lei; Yu, Cong, E-mail: muduri@shao.ac.cn, E-mail: cyu@ynao.ac.cn

2014-04-01

We propose a catastrophic eruption model for the enormous energy release of magnetars during giant flares, in which a toroidal and helically twisted flux rope is embedded within a force-free magnetosphere. The flux rope stays in stable equilibrium states initially and evolves quasi-statically. Upon the loss of equilibrium, the flux rope cannot sustain the stable equilibrium states and erupts catastrophically. During the process, the magnetic energy stored in the magnetosphere is rapidly released as the result of destabilization of global magnetic topology. The magnetospheric energy that could be accumulated is of vital importance for the outbursts of magnetars. We carefullymore » establish the fully open fields and partially open fields for various boundary conditions at the magnetar surface and study the relevant energy thresholds. By investigating the magnetic energy accumulated at the critical catastrophic point, we find that it is possible to drive fully open eruptions for dipole-dominated background fields. Nevertheless, it is hard to generate fully open magnetic eruptions for multipolar background fields. Given the observational importance of the multipolar magnetic fields in the vicinity of the magnetar surface, it would be worthwhile to explore the possibility of the alternative eruption approach in multipolar background fields. Fortunately, we find that flux ropes may give rise to partially open eruptions in the multipolar fields, which involve only partial opening of background fields. The energy release fractions are greater for cases with central-arcaded multipoles than those with central-caved multipoles that emerged in background fields. Eruptions would fail only when the centrally caved multipoles become extremely strong.« less

Effect of interleukin-1beta on the behavior of rats during mild stress in the open-field test.

PubMed

Pertsov, S S; Koplik, E V; Simbirtsev, A S; Kalinichenko, L S

2009-11-01

We studied the effect of interleukin-1beta on the behavior of rats with different individual typological characteristics during mild stress in the open-field test. Intraperitoneal injection of interleukin-1beta (5 microg/kg, 108 U/mg) was followed by a decrease in orientation and exploratory activity of passive and, particularly, of active animals in the open field. As differentiated from rats receiving physiological saline, the initial differences in behavioral characteristics of active and passive animals were not revealed in the repeated test after injection of interleukin-1beta. We conclude that interleukin-1beta abolishes the behavioral differences between active and passive specimens in the open field. These data suggest that administration of interleukin-1beta to rats leads to reorganization of the mechanisms for emotional evaluation of adverse emotiogenic factors under conditions of mild stress in the open-field test.

Comparative in vitro anti-tick efficacy of commercially available products and newly developed phyto-formulations against field collected and resistant tick lines of Rhipicephalus (Boophilus) microplus.

PubMed

Ajith Kumar, K G; Sharma, Anil Kumar; Kumar, Sachin; Ray, D D; Rawat, A K S; Srivastava, Sharad; Ghosh, Srikant

2016-12-01

Rhipicephalus ( Boophilus ) microplus is considered as one of the most widely distributed tick species ecto-parasitizing on livestock and causes fatal diseases with significant production loss. To address the problem of controlling acaricide resistant tick infestations on animals, attention has been paid to develop eco-friendly phyto-acaricides. The present study was undertaken to evaluate the comparative anti-tick activities of commercially available herbal and chemical products with chemically characterized phyto-formulations developed recently against field ticks and resistant tick lines of R. ( B. ) microplus . The chemical product Butox ® Vet was found nearly passive against all the tested resistant tick lines. However, one of the commercial polyherbal product, Zerokeet ® showed an efficacy (E%) of 41.8-75.4 % ([Formula: see text]) using recommended dilution (1:2) against field ticks and resistant tick lines. However, the other commercial product, Erina ® EP has very limited efficacy against all the tested tick. In comparison, the newly developed phyto-formulation, NBA/13/B/2 and NAC-01 conferred an E% of 82.4-91.3 % ([Formula: see text]) and 62.3-94.6 % ([Formula: see text]), respectively, against tested resistant ticks. Results indicated higher marketing potentiality of newly developed formulation in the existing tick problem scenario.

Intrinsically Disordered Protein Specific Force Field CHARMM36IDPSFF.

PubMed

Liu, Hao; Song, Dong; Lu, Hui; Luo, Ray; Chen, Hai-Feng

2018-05-28

Intrinsically disordered proteins (IDPs) are closely related to various human diseases. Because IDPs lack certain tertiary structure, it is difficult to use X-ray and NMR methods to measure their structures. Therefore, molecular dynamics simulation is a useful tool to study the conformer distribution of IDPs. However, most generic protein force fields were found to be insufficient in simulations of IDPs. Here we report our development for the CHARMM community. Our residue-specific IDP force field (CHARMM36IDPSFF) was developed based on the base generic force field with CMAP corrections of for all 20 naturally occurring amino acids. Multiple tests show that the simulated chemical shifts with the newly developed force field are in quantitative agreement with NMR experiment and are more accurate than the base generic force field. Comparison of J-couplings with previous work shows that CHARMM36IDPSFF and its corresponding base generic force field have their own advantages. In addition, CHARMM36IDPSFF simulations also agree with experiment for SAXS profiles and radii of gyration of IDPs. Detailed analysis shows that CHARMM36IDPSFF can sample more diverse and disordered conformers. These findings confirm that the newly developed force field can improve the balance of accuracy and efficiency for the conformer sampling of IDPs. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

The $16,819 pay gap for newly trained physicians: the unexplained trend of men earning more than women.

PubMed

Lo Sasso, Anthony T; Richards, Michael R; Chou, Chiu-Fang; Gerber, Susan E

2011-02-01

Prior research has suggested that gender differences in physicians' salaries can be accounted for by the tendency of women to enter primary care fields and work fewer hours. However, in examining starting salaries by gender of physicians leaving residency programs in New York State during 1999-2008, we found a significant gender gap that cannot be explained by specialty choice, practice setting, work hours, or other characteristics. The unexplained trend toward diverging salaries appears to be a recent development that is growing over time. In 2008, male physicians newly trained in New York State made on average $16,819 more than newly trained female physicians, compared to a $3,600 difference in 1999.

Thermodynamical properties of liquid lanthanides-A variational approach

NASA Astrophysics Data System (ADS)

Patel, H. P.; Thakor, P. B.; Sonvane, Y. A.

2015-06-01

Thermodynamical properties like Entropy (S), Internal energy (E) and Helmholtz free energy (F) of liquid lanthanides using a variation principle based on the Gibbs-Bogoliubuv (GB) inequality with Percus Yevick hard sphere reference system have been reported in the present investigation. To describe electron-ion interaction we have used our newly constructed parameter free model potential along with Sarkar et al. local field correction function. Lastly, we conclude that our newly constructed model potential is capable to explain the thermodynamical properties of liquid lanthanides.

Thermodynamical properties of liquid lanthanides-A variational approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patel, H. P.; Department of Applied Physics, S. V. National Institute of Technology, Surat 395 007, Gujarat; Thakor, P. B., E-mail: pbthakor@rediffmail.com

2015-06-24

Thermodynamical properties like Entropy (S), Internal energy (E) and Helmholtz free energy (F) of liquid lanthanides using a variation principle based on the Gibbs-Bogoliubuv (GB) inequality with Percus Yevick hard sphere reference system have been reported in the present investigation. To describe electron-ion interaction we have used our newly constructed parameter free model potential along with Sarkar et al. local field correction function. Lastly, we conclude that our newly constructed model potential is capable to explain the thermodynamical properties of liquid lanthanides.

Current-level triggered plasma-opening switch

DOEpatents

Mendel, C.W.

1987-06-29

An opening switch for very high power electrical pulses uses a slow magnetic field to confine a plasma across a gap between two electrodes. The plasma conducts the electric pulse across the gap while the switch is closed. A magnetic field generated by the pulse repels the slow magnetic field from the negative electrode to push the plasma from the electrode, opening the switch. A plurality of radial vanes may be used to enhance the slow magnetic field. 5 figs.

Current-level triggered plasma-opening switch

DOEpatents

Mendel, Clifford W.

1989-01-01

An opening switch for very high power electrical pulses uses a slow magnetic field to confine a plasma across a gap between two electrodes. The plasma conducts the electric pulse across the gap while the switch is closed. A magnetic field generated by the pulse repels the slow magnetic field from the negative electrode to push the plasma from the electrode, opening the switch. A plurality of radial vanes may be used to enhance the slow magnetic field.

Weather forecasting with open source software

NASA Astrophysics Data System (ADS)

Rautenhaus, Marc; Dörnbrack, Andreas

2013-04-01

To forecast the weather situation during aircraft-based atmospheric field campaigns, we employ a tool chain of existing and self-developed open source software tools and open standards. Of particular value are the Python programming language with its extension libraries NumPy, SciPy, PyQt4, Matplotlib and the basemap toolkit, the NetCDF standard with the Climate and Forecast (CF) Metadata conventions, and the Open Geospatial Consortium Web Map Service standard. These open source libraries and open standards helped to implement the "Mission Support System", a Web Map Service based tool to support weather forecasting and flight planning during field campaigns. The tool has been implemented in Python and has also been released as open source (Rautenhaus et al., Geosci. Model Dev., 5, 55-71, 2012). In this presentation we discuss the usage of free and open source software for weather forecasting in the context of research flight planning, and highlight how the field campaign work benefits from using open source tools and open standards.

Olfactory source localization in the open field using one or both nostrils.

PubMed

Welge-Lussen, A; Looser, G L; Westermann, B; Hummel, T

2014-03-01

This study aims to examine humans ́ abilities to localize odorants within the open field. Young participants were tested on a localization task using a relatively selective olfactory stimulus (2-phenylethyl-alcohol, PEA) and cineol, an odorant with a strong trigeminal component. Participants were blindfolded and had to localize an odorant source at 2 m distance (far-field condition) and a 0.4 m distance (near-field condition) with either two nostrils open or only one open nostril. For the odorant with trigeminal properties, the number of correct trials did not differ when one or both nostrils were used, while more PEA localization trials were correctly completed with both rather than one nostril. In the near-field condition, correct localization was possible in 72-80% of the trials, irrespective of the odorant and the number of nostrils used. Localization accuracy, measured as spatial deviation from the olfactory source, was significantly higher in the near-field compared to the far-field condition, but independent of the odorant being localized. Odorant localization within the open field is difficult, but possible. In contrast to the general view, humans seem to be able to exploit the two-nostril advantage with increasing task difficulty.

Former Spencer Artillery Range, Tennessee Classification Demonstration Open Field and Dynamic Areas

DTIC Science & Technology

2016-01-01

DEMONSTRATION REPORT Former Spencer Artillery Range, Tennessee Classification Demonstration Open Field and Dynamic Areas ESTCP...AVAILABILITY STATEMENT 13. SUPPLEMENTARY NOTES 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: a. REPORT b. ABSTRACT c. THIS PAGE 17...2016 Technical Report N/A Former Spencer Artillery Range, Tennessee Classification Demonstration Open Field and Dynamic Areas Richard MacNeil, USA

A Comparison of Antenna Measurements in a Near-Field Range and a Newly Renovated Short-Tapered Chamber

DTIC Science & Technology

2016-09-01

SUPPLEMENTARY NOTES 14. ABSTRACT This study was undertaken to quantify and compare electromagnetic device (i.e., antenna) measurements using the US Army...15. SUBJECT TERMS electromagnetic , chamber, near-field range, anechoic chamber, antenna measurement 16. SECURITY CLASSIFICATION OF: 17...undertaken to quantify and compare electromagnetic (EM) device (i.e., antenna) measurements using the US Army Research Laboratory’s (ARL’s) near-field

Employer Accommodation and Labor Supply of Disabled Workers*

PubMed Central

Hill, Matthew J.; Maestas, Nicole; Mullen, Kathleen J.

2016-01-01

We examine the factors that influence employer accommodation of newly disabled workers and how effective such accommodations are in retaining workers and discouraging disability insurance applications. Using the Health and Retirement Study, we find that only a quarter of newly disabled older workers in their 50s are accommodated by their employers in some way following onset of a disability. Importantly, we find that few employer characteristics explain which workers are accommodated; rather, employee characteristics, particularly the presence of personality traits correlated with assertiveness and open communication, are highly predictive of accommodation. We also find that if employer accommodation rates could be increased, disabled workers would be significantly more likely to delay labor force exit for up to two years. However, accommodation does not appear to reduce subsequent disability insurance claiming. PMID:27840560

Shear-induced opening of the coronal magnetic field

NASA Technical Reports Server (NTRS)

Wolfson, Richard

1995-01-01

This work describes the evolution of a model solar corona in response to motions of the footpoints of its magnetic field. The mathematics involved is semianalytic, with the only numerical solution being that of an ordinary differential equation. This approach, while lacking the flexibility and physical details of full MHD simulations, allows for very rapid computation along with complete and rigorous exploration of the model's implications. We find that the model coronal field bulges upward, at first slowly and then more dramatically, in response to footpoint displacements. The energy in the field rises monotonically from that of the initial potential state, and the field configuration and energy appraoch asymptotically that of a fully open field. Concurrently, electric currents develop and concentrate into a current sheet as the limiting case of the open field is approached. Examination of the equations shows rigorously that in the asymptotic limit of the fully open field, the current layer becomes a true ideal MHD singularity.

RocKeTeria restaurant

NASA Technical Reports Server (NTRS)

2000-01-01

When StenniSphere at John C. Stennis Space Center in Hancock County, Miss., opened in May 2000, it introduced the RocKeTeria, a new 1960s-style, space-themed restaurant located in the newly expanded visitor center. The restaurant, operated by the owners of Mary's Drive Inn of Biloxi, features an extensive collection of space-related photos from that era, as well as a full menu of home-style cooking.

Bear damage to young Douglas-fir.

Treesearch

Thomas W. Childs; Norman P. Worthington

1955-01-01

Newly-formed sapwood of young conifers has probably been a food for bears since time immemorial, but damage to trees has only recently attracted the attention of foresters. In many localities, all stages of bear-caused wounds can be found, from fresh ones to those covered with callus, On a 3-acre clear-cut, made in 1950 in a rather open part of the 110-year-old stand...

When Pandora's Box Is Opened: A Qualitative Study of the Intended and Unintended Impacts of Wyoming's New Standardized Tests on Local Educators' Everyday Practices

ERIC Educational Resources Information Center

Cho, Jeasik; Eberhard, Brian

2013-01-01

In the context of a newly adopted statewide assessment system, PAWS (Proficiency Assessment for Wyoming Students), this paper describes intended instructional changes and unintended outcomes in classrooms and schools as a result of an assessment policy involving an innovative online portion of the test. An elementary school was selected and…

Unifying Faculty, Staff, Students, and Community by Establishing and Implementing a Unique Vision for a New Elementary School.

ERIC Educational Resources Information Center

Currie, John R.

The principal of a newly opened elementary school implemented a practicum study designed to unify faculty, parents, staff, and children; add direction to the program; develop a sense of purpose; and increase participation. It was expected that a vision statement would be developed in the school's first year of operation, and that parents and staff…

Neptune: An astrophysical smooth particle hydrodynamics code for massively parallel computer architectures

NASA Astrophysics Data System (ADS)

Sandalski, Stou

Smooth particle hydrodynamics is an efficient method for modeling the dynamics of fluids. It is commonly used to simulate astrophysical processes such as binary mergers. We present a newly developed GPU accelerated smooth particle hydrodynamics code for astrophysical simulations. The code is named neptune after the Roman god of water. It is written in OpenMP parallelized C++ and OpenCL and includes octree based hydrodynamic and gravitational acceleration. The design relies on object-oriented methodologies in order to provide a flexible and modular framework that can be easily extended and modified by the user. Several pre-built scenarios for simulating collisions of polytropes and black-hole accretion are provided. The code is released under the MIT Open Source license and publicly available at http://code.google.com/p/neptune-sph/.

Apollo 1 Tribute Opening

NASA Image and Video Library

2017-01-27

Lowell Grissom, brother of Gus Grissom, and Carly Sparks, granddaughter of Grissom, look at areas of the newly opened Apollo 1 tribute at the Apollo/Saturn V Center at NASA's Kennedy Space Center opened Jan. 27, 2017. Astronauts Gus Grissom, Ed White II and Chaffee perished in a fire at the launch pad on Jan. 27, 1967, during training for the mission. The tribute highlights the lives and careers of the astronauts. The tribute features numerous items recalling the lives of the three astronauts. The tribute also includes the three-part hatch to the spacecraft itself, the first time any part of the Apollo 1 spacecraft has been displayed publicly. A version of the hatch after it was redesigned is also showcased as an example of improvements NASA made throughout the agency and to the Apollo spacecraft that would later carry astronauts to the moon.

Apollo 1 Tribute Opening

NASA Image and Video Library

2017-01-27

Martha Chaffee and Sheryl Chaffee, widow and daughter of astronaut Roger Chaffee, respectively, look at areas of the newly opened Apollo 1 tribute at the Apollo/Saturn V Center at NASA's Kennedy Space Center opened Jan. 27, 2017. Astronauts Gus Grissom, Ed White II and Chaffee perished in a fire at the launch pad on Jan. 27, 1967, during training for the mission. The tribute highlights the lives and careers of the astronauts. The tribute features numerous items recalling the lives of the three astronauts. The tribute also includes the three-part hatch to the spacecraft itself, the first time any part of the Apollo 1 spacecraft has been displayed publicly. A version of the hatch after it was redesigned is also showcased as an example of improvements NASA made throughout the agency and to the Apollo spacecraft that would later carry astronauts to the moon.

CHARMM additive and polarizable force fields for biophysics and computer-aided drug design.

PubMed

Vanommeslaeghe, K; MacKerell, A D

2015-05-01

Molecular Mechanics (MM) is the method of choice for computational studies of biomolecular systems owing to its modest computational cost, which makes it possible to routinely perform molecular dynamics (MD) simulations on chemical systems of biophysical and biomedical relevance. As one of the main factors limiting the accuracy of MD results is the empirical force field used, the present paper offers a review of recent developments in the CHARMM additive force field, one of the most popular biomolecular force fields. Additionally, we present a detailed discussion of the CHARMM Drude polarizable force field, anticipating a growth in the importance and utilization of polarizable force fields in the near future. Throughout the discussion emphasis is placed on the force fields' parametrization philosophy and methodology. Recent improvements in the CHARMM additive force field are mostly related to newly found weaknesses in the previous generation of additive force fields. Beyond the additive approximation is the newly available CHARMM Drude polarizable force field, which allows for MD simulations of up to 1μs on proteins, DNA, lipids and carbohydrates. Addressing the limitations ensures the reliability of the new CHARMM36 additive force field for the types of calculations that are presently coming into routine computational reach while the availability of the Drude polarizable force fields offers an inherently more accurate model of the underlying physical forces driving macromolecular structures and dynamics. This article is part of a Special Issue entitled "Recent developments of molecular dynamics". Copyright © 2014 Elsevier B.V. All rights reserved.

Effects of nanotechnologies-based devices on postural control in healthy subjects.

PubMed

Malchiodi Albedi, Giovanna; Corna, Stefano; Aspesi, Valentina; Clerici, Daniela; Parisio, Cinzia; Seitanidis, Jonathan; Cau, Nicola; Brugliera, Luigia; Capodaglio, Paolo

2017-09-05

The aim of the present preliminary randomized controlled study was to ascertain whether the use of newly developed nanotechnologies-based patches can influence posture control of healthy subjects. Thirty healthy female subjects (age 39.4 years, BMI 22.74 kg/m2) were randomly assigned to two groups: one with active patches and a control group with sham patches. Two patches were applied with a tape: one on the subject's sternum and the other on the C7 apophysis. Body sway during quiet upright stance was recorded with a dynamometric platform. Each subject was tested under two visual conditions, eyes open and closed. We used a blocked stratified randomization procedure conducted by a third party. Subjects wearing the sham patches showed a significant increase of the centre of pressure sway area after 4 hours when they performed the habitual moderate-intensity work activities. In the active patch group, a decrease of the sway path was evident, providing evidence of an enhanced balance control. Our preliminary findings on healthy subjects indicate that nanotechnological devices generating ultra-low electromagnetic fields can improve posture control.

The 1999 eruption of Shishaldin Volcano, Alaska: Monitoring a distant eruption

USGS Publications Warehouse

Nye, C.J.; Keith, T.E.C.; Eichelberger, J.C.; Miller, T.P.; McNutt, S.R.; Moran, S.; Schneider, D.J.; Dehn, J.; Schaefer, J.R.

2002-01-01

Shishaldin Volcano, in the central Aleutian volcanic arc, became seismically restless during the summer of 1998. Increasing unrest was monitored using a newly installed seismic network, weather satellites, and rare local visual observations. The unrest culminated in large eruptions on 19 April and 22-23 April 1999. The opening phase of the 19 April eruption produced a sub-Plinian column that rose to 16 km before rapidly dissipating. About 80 min into the 19 April event we infer that the eruption style transitioned to vigorous Strombolian fountaining. Exceptionally vigorous seismic tremor heralded the 23 April eruption, which produced a large thermal anomaly observable by satellite, but only a modest, 6-km-high plume. There are no ground-based visual observations of this eruption; however we infer that there was renewed, vigorous Strombolian fountaining. Smaller low-level ash-rich plumes were produced through the end of May 1999. The lava that erupted was evolved basalt with about 49% SiO2. Subsequent field investigations have been unable to find a distinction between deposits from each of the two major eruptive episodes.

Smart Health - Potential and Pathways: A Survey

NASA Astrophysics Data System (ADS)

Arulananthan, C.; Hanifa, Sabibullah Mohamed

2017-08-01

Healthcare is an imperative key field of research, where individuals or groups can be engaged in the self-tracking of any kind of biological, physical, behavioral, or environmental information. In a massive health care data, the valuable information is hidden. The quantity of the available unstructured data has been expanding on an exponential scale. The newly developing Disruptive Technologies can handle many challenges that face data analysis and ability to extract valuable information via data analytics. Connected Wellness in Healthcare would retrieve patient’s physiological, pathological and behavioral parameters through sensors to perform inner workings of human body analysis. Disruptive technologies can take us from a reactive illness-driven to a proactive wellness-driven system in health care. It is need to be strive and create a smart health system towards wellness-driven instead of being illness-driven, today’s biggest problem in health care. Wellness-driven-analytics application help to promote healthiest living environment called “Smart Health”, deliver empower based quality of living. The contributions of this survey reveals and opens (touches uncovered areas) the possible doors in the line of research on smart health and its computing technologies.

A Survey of Protein Structures from Archaeal Viruses

PubMed Central

Dellas, Nikki; Lawrence, C. Martin; Young, Mark J.

2013-01-01

Viruses that infect the third domain of life, Archaea, are a newly emerging field of interest. To date, all characterized archaeal viruses infect archaea that thrive in extreme conditions, such as halophilic, hyperthermophilic, and methanogenic environments. Viruses in general, especially those replicating in extreme environments, contain highly mosaic genomes with open reading frames (ORFs) whose sequences are often dissimilar to all other known ORFs. It has been estimated that approximately 85% of virally encoded ORFs do not match known sequences in the nucleic acid databases, and this percentage is even higher for archaeal viruses (typically 90%–100%). This statistic suggests that either virus genomes represent a larger segment of sequence space and/or that viruses encode genes of novel fold and/or function. Because the overall three-dimensional fold of a protein evolves more slowly than its sequence, efforts have been geared toward structural characterization of proteins encoded by archaeal viruses in order to gain insight into their potential functions. In this short review, we provide multiple examples where structural characterization of archaeal viral proteins has indeed provided significant functional and evolutionary insight. PMID:25371334

Magnetic tagging of cell-derived microparticles: new prospects for imaging and manipulation of these mediators of biological information.

PubMed

Vats, Nidhi; Wilhelm, Claire; Rautou, Pierre-Emmanuel; Poirier-Quinot, Marie; Péchoux, Christine; Devue, Cécile; Boulanger, Chantal M; Gazeau, Florence

2010-07-01

Submicron membrane fragments termed microparticles (MPs), which are released by apoptotic or activated cells, are newly considered as vectors of biological information and actors of pathology development. We propose the tagging of MPs with magnetic nanoparticles as a new approach allowing imaging, manipulation and targeting of cell-derived MPs. MPs generated in vitro from human endothelial cells or isolated from atherosclerotic plaques were labeled using citrate-coated 8 nm iron-oxide nanoparticles. MPs were tagged with magnetic nanoparticles on their surface and detected as Annexin-V positive by flow cytometry. Labeled MPs could be mobilized, isolated and manipulated at a distance in a magnetic field gradient. Magnetic mobility of labeled MPs was quantified by micromagnetophoresis. Interactions of labeled MPs with endothelial cells could be triggered and modulated by magnetic guidance. Nanoparticles served as tracers at different scales: at the subcellular level by electron microscopy, at the cellular level by histology and at the macroscopic level by MRI. Magnetic labeling of biogenic MPs opens new prospects for noninvasive monitoring and distal manipulations of these biological effectors.

Census of the Local Universe (CLU) Hα Galaxy Survey: Characterization of Galaxy Catalogs from Preliminary Fields

NASA Astrophysics Data System (ADS)

Cook, David O.; Kasliwal, Mansi; Van Sistine, Anglea; Kaplan, David; iPTF

2018-01-01

In this talk I introduce the Census of the Local Universe (CLU) galaxy survey. The survey uses 4 wavelength-adjacent, narrowband filters to search for emission-line (Hα) sources across ~3π (26,470 deg2) of the sky and out to distance of 200 Mpc. I will present an analysis of galaxy candidates in 14 preliminary fields (out of 3626) to assess the limits of the survey and the potential for finding new galaxies in the local Universe. We anticipate finding tens-of-thousands of new galaxies in the full ~3π survey. In addition, I present some interesting galaxies found in these fields, which include: newly discovered blue compact dwarfs (e.g., blueberries), 1 new green pea, 1 new QSO, and a known planetary nebula. The majority of the CLU galaxies show properties similar to normal star-forming galaxies; however, the newly discovered blueberries tend to have high star formation rates for their given stellar mass.

First CCD UBVI photometric analysis of six open cluster candidates

NASA Astrophysics Data System (ADS)

Piatti, A. E.; Clariá, J. J.; Ahumada, A. V.

2011-04-01

We have obtained CCD UBVIKC photometry down to V ˜ 22 for the open cluster candidates Haffner 3, Haffner 5, NGC 2368, Haffner 25, Hogg 3 and Hogg 4 and their surrounding fields. None of these objects have been photometrically studied so far. Our analysis shows that these stellar groups are not genuine open clusters since no clear main sequences or other meaningful features can be seen in their colour-magnitude and colour-colour diagrams. We checked for possible differential reddening across the studied fields that could be hiding the characteristics of real open clusters. However, the dust in the directions to these objects appears to be uniformly distributed. Moreover, star counts carried out within and outside the open cluster candidate fields do not support the hypothesis that these objects are real open clusters or even open cluster remnants.

Crowd Sourcing for Challenging Technical Problems and Business Model

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.; Richard, Elizabeth

2011-01-01

Crowd sourcing may be defined as the act of outsourcing tasks that are traditionally performed by an employee or contractor to an undefined, generally large group of people or community (a crowd) in the form of an open call. The open call may be issued by an organization wishing to find a solution to a particular problem or complete a task, or by an open innovation service provider on behalf of that organization. In 2008, the Space Life Sciences Directorate (SLSD), with the support of Wyle Integrated Science and Engineering, established and implemented pilot projects in open innovation (crowd sourcing) to determine if these new internet-based platforms could indeed find solutions to difficult technical challenges. These unsolved technical problems were converted to problem statements, also called "Challenges" or "Technical Needs" by the various open innovation service providers, and were then posted externally to seek solutions. In addition, an open call was issued internally to NASA employees Agency wide (10 Field Centers and NASA HQ) using an open innovation service provider crowd sourcing platform to post NASA challenges from each Center for the others to propose solutions). From 2008 to 2010, the SLSD issued 34 challenges, 14 externally and 20 internally. The 14 external problems or challenges were posted through three different vendors: InnoCentive, Yet2.com and TopCoder. The 20 internal challenges were conducted using the InnoCentive crowd sourcing platform designed for internal use by an organization. This platform was customized for NASA use and promoted as NASA@Work. The results were significant. Of the seven InnoCentive external challenges, two full and five partial awards were made in complex technical areas such as predicting solar flares and long-duration food packaging. Similarly, the TopCoder challenge yielded an optimization algorithm for designing a lunar medical kit. The Yet2.com challenges yielded many new industry and academic contacts in bone imaging, microbial detection and even the use of pharmaceuticals for radiation protection. The internal challenges through NASA@Work drew over 6000 participants across all NASA centers. Challenges conducted by each NASA center elicited ideas and solutions from several other NASA centers and demonstrated rapid and efficient participation from employees at multiple centers to contribute to problem solving. Finally, on January 19, 2011, the SLSD conducted a workshop on open collaboration and innovation strategies and best practices through the newly established NASA Human Health and Performance Center (NHHPC). Initial projects will be described leading to a new business model for SLSD.

Jet outflow and open field line measurements on the C-2U advanced beam-driven field-reversed configuration plasma experiment.

PubMed

Sheftman, D; Gupta, D; Roche, T; Thompson, M C; Giammanco, F; Conti, F; Marsili, P; Moreno, C D

2016-11-01

Knowledge and control of the axial outflow of plasma particles and energy along open-magnetic-field lines are of crucial importance to the stability and longevity of the advanced beam-driven field-reversed configuration plasma. An overview of the diagnostic methods used to perform measurements on the open field line plasma on C-2U is presented, including passive Doppler impurity spectroscopy, microwave interferometry, and triple Langmuir probe measurements. Results of these measurements provide the jet ion temperature and axial velocity, electron density, and high frequency density fluctuations.

Jet outflow and open field line measurements on the C-2U advanced beam-driven field-reversed configuration plasma experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheftman, D., E-mail: dsheftman@trialphaenergy.com; Gupta, D.; Roche, T.

Knowledge and control of the axial outflow of plasma particles and energy along open-magnetic-field lines are of crucial importance to the stability and longevity of the advanced beam-driven field-reversed configuration plasma. An overview of the diagnostic methods used to perform measurements on the open field line plasma on C-2U is presented, including passive Doppler impurity spectroscopy, microwave interferometry, and triple Langmuir probe measurements. Results of these measurements provide the jet ion temperature and axial velocity, electron density, and high frequency density fluctuations.

A nonsingular model of the open magnetosphere

NASA Technical Reports Server (NTRS)

Toffoletto, F. R.; Hill, T. W.

1993-01-01

We present a modified version of the Toffoletto and Hill (1989) open magnetosphere model that incorporates a tail-like interconection field with a discontinuity 10 represent the slow-mode expansion fan that defines the high-latitude tail magnetopause. (The interconnection field is defined as the perturbation on an initially closed magnetosphere model to make it open.) The expansion fan controls the open field line region in the tail, and the intersection of the fan with the tail current sheet is, by design, the x line. The new interconnection field allows greater control of the tail field structure; in particular, it enables us to eliminate the nightside mapping singularity that occurs in previous models when the interplanetary magnetic field is nonsouthward. Also, in contrast to earlier models, the far tail x line extends farther downstream on the flanks than in the center of the tail, consistent with observations.

Embedding Culture in a Field Experience Seminar: Lessons Learned about Promoting Preservice Teacher Critical Consciousness in an Urban School Partnership

ERIC Educational Resources Information Center

Jacobs, Jennifer; Casciola, Vanessa; Arndt, Katie; Mallory, Mashainah

2015-01-01

This article reports the research findings of teacher educator inquiry using qualitative methods examining how incorporating the topic of culture into the field seminar component of a newly developed urban school-university partnership influenced preservice teachers' abilities to become critically conscious. After analyzing preservice teacher…

MSSP [Marin Social Studies Project]. Field Test Results 1968-69; 1969-70.

ERIC Educational Resources Information Center

Marin County Superintendent of Schools, Corte Madera, CA.

During the first two years of operation the Marin Social Studies Project field tested a variety of newly developed social studies curriculum materials throughout Marin County. This document is a compilation of the data which was collected from teachers and students regarding these materials. The results are reported in three sections: primary…

48 CFR 2406.304-70 - Approval of the justification-field procurements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Other Than Full and Open Competition 2406.304-70 Approval of the justification—field procurements. (a) The justification for other than full and open competition for field procurements shall be approved in... justification-field procurements. 2406.304-70 Section 2406.304-70 Federal Acquisition Regulations System...

47 CFR 2.1053 - Measurements required: Field strength of spurious radiation.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... For equipment operating on frequencies below 890 MHz, an open field test is normally required, with... either impractical or impossible to make open field measurements (e.g. a broadcast transmitter installed... 47 Telecommunication 1 2010-10-01 2010-10-01 false Measurements required: Field strength of...

Robotic digital subtraction angiography systems within the hybrid operating room.

PubMed

Murayama, Yuichi; Irie, Koreaki; Saguchi, Takayuki; Ishibashi, Toshihiro; Ebara, Masaki; Nagashima, Hiroyasu; Isoshima, Akira; Arakawa, Hideki; Takao, Hiroyuki; Ohashi, Hiroki; Joki, Tatsuhiro; Kato, Masataka; Tani, Satoshi; Ikeuchi, Satoshi; Abe, Toshiaki

2011-05-01

Fully equipped high-end digital subtraction angiography (DSA) within the operating room (OR) environment has emerged as a new trend in the fields of neurosurgery and vascular surgery. To describe initial clinical experience with a robotic DSA system in the hybrid OR. A newly designed robotic DSA system (Artis zeego; Siemens AG, Forchheim, Germany) was installed in the hybrid OR. The system consists of a multiaxis robotic C arm and surgical OR table. In addition to conventional neuroendovascular procedures, the system was used as an intraoperative imaging tool for various neurosurgical procedures such as aneurysm clipping and spine instrumentation. Five hundred one neurosurgical procedures were successfully conducted in the hybrid OR with the robotic DSA. During surgical procedures such as aneurysm clipping and arteriovenous fistula treatment, intraoperative 2-/3-dimensional angiography and C-arm-based computed tomographic images (DynaCT) were easily performed without moving the OR table. Newly developed virtual navigation software (syngo iGuide; Siemens AG) can be used in frameless navigation and in access to deep-seated intracranial lesions or needle placement. This newly developed robotic DSA system provides safe and precise treatment in the fields of endovascular treatment and neurosurgery.

Manual versus Automated Rodent Behavioral Assessment: Comparing Efficacy and Ease of Bederson and Garcia Neurological Deficit Scores to an Open Field Video-Tracking System.

PubMed

Desland, Fiona A; Afzal, Aqeela; Warraich, Zuha; Mocco, J

2014-01-01

Animal models of stroke have been crucial in advancing our understanding of the pathophysiology of cerebral ischemia. Currently, the standards for determining neurological deficit in rodents are the Bederson and Garcia scales, manual assessments scoring animals based on parameters ranked on a narrow scale of severity. Automated open field analysis of a live-video tracking system that analyzes animal behavior may provide a more sensitive test. Results obtained from the manual Bederson and Garcia scales did not show significant differences between pre- and post-stroke animals in a small cohort. When using the same cohort, however, post-stroke data obtained from automated open field analysis showed significant differences in several parameters. Furthermore, large cohort analysis also demonstrated increased sensitivity with automated open field analysis versus the Bederson and Garcia scales. These early data indicate use of automated open field analysis software may provide a more sensitive assessment when compared to traditional Bederson and Garcia scales.

Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice.

PubMed

Lalonde, R; Strazielle, C

2008-06-15

The relations between open-field, elevated plus-maze, and emergence tests were examined in two strains of mice. In the open-field, C57BL/6J mice had more ambulatory movements and rears but not stereotyped movements relative to BALB/c. In addition, C57BL/6J mice entered more often than BALB/c into enclosed and open arms of the elevated plus-maze. When placed inside a large enclosure, C57BL/6J mice emerged more quickly than BALB/c from a small toy object. In the entire series of mice, ambulation and rears in the open-field were linearly correlated with open and enclosed arm visits in the elevated plus-maze. Ambulatory movements and rears were also correlated with emergence latencies. In contrast, stereotyped movements were correlated with emergence latencies, but not with any elevated plus-maze value. These results specify the extent and limits of association between the three tests.

Forward Field Computation with OpenMEEG

PubMed Central

Gramfort, Alexandre; Papadopoulo, Théodore; Olivi, Emmanuel; Clerc, Maureen

2011-01-01

To recover the sources giving rise to electro- and magnetoencephalography in individual measurements, realistic physiological modeling is required, and accurate numerical solutions must be computed. We present OpenMEEG, which solves the electromagnetic forward problem in the quasistatic regime, for head models with piecewise constant conductivity. The core of OpenMEEG consists of the symmetric Boundary Element Method, which is based on an extended Green Representation theorem. OpenMEEG is able to provide lead fields for four different electromagnetic forward problems: Electroencephalography (EEG), Magnetoencephalography (MEG), Electrical Impedance Tomography (EIT), and intracranial electric potentials (IPs). OpenMEEG is open source and multiplatform. It can be used from Python and Matlab in conjunction with toolboxes that solve the inverse problem; its integration within FieldTrip is operational since release 2.0. PMID:21437231

A Measurement and Analysis of Buildup Region Dose for Open Field Photon Beams (Cobalt-60 through 24 MV)

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCullough, Edwin C.

2015-01-15

The central axis depth dose in the build-up region (surface to d{sub max}) of single open field photon beams (cobalt-60 through 24 MV) has been measured utilizing parallel plate and extrapolation chamber methodology. These data were used to derive, for a prescription dose of 100 cGy, values of surface dose, the maximum value of dose along the central axis (D{sub max}) and the depth (nearest the surface) at which 90% of the prescription dose occurs (d{sub 90}). For both single and parallel opposed pair (POP) open field configurations, data are presented at field sizes of 5 × 5, 15 ×more » 15 and 25 × 25 cm{sup 2} for prescription depths of 10, 15 and 20 cm (midplane for POP). For the treatment machines, field sizes, and prescription depths studied, it is possible to conclude that: for single open field irradiation, surface dose values (as a percentage of the prescription dose) can be either low (<10%) or comparable to the prescription dose itself; for POP open fields, surface dose values are relatively independent of photon energy and midplane depth, and range between 30% and 70% of prescription dose, being principally dependent on field size; the depth of the initial 90 cGy point for a prescription dose of 100 cGy, d{sub 90}, was larger for POP fields. For either single or POP open field treatments, d{sub 90} was always less than 22 mm, while for 6 MV or less, values of d{sub 90} were less than 4 mm; D{sub max} values can be very large (e.g., above 300 cGy) for certain treatment situations and are reduced significantly for POP treatments; for open field POP treatments, the percent reduction in D{sub max} with each increment in beam energy above 10 MV is reduced over that seen at 10 MV or less and, possibly, this further reduction may be clinically insignificant; for open field POP treatments, changes in surface dose, d{sub 90} and D{sub max} with beam energy above 10 MV do not suggest, with regard to these specific build-up curve parameters, any obvious advantage for treatment with beam energies greater than 10 MV for the specific machines and situations studied.« less

Effect of biomass open burning on particulate matter and polycyclic aromatic hydrocarbon concentration levels and PAH dry deposition in ambient air.

PubMed

Chiu, Jui C; Shen, Yun H; Li, Hsing W; Chang, Shun S; Wang, Lin C; Chang-Chien, Guo P

2011-01-01

The objectives of the present study were to investigate particulate matter (PM) and polycyclic aromatic hydrocarbon (PAH) concentrations in ambient air during rice straw open burning and non-open burning periods. In the ambient air of a rice field, the mean PM concentration during and after an open burning event were 1828 and 102 μg m⁻³, respectively, which demonstrates that during a rice field open burning event, the PM concentration in the ambient air of rice field is over 17 times higher than that of the non-open burning period. During an open burning event, the mean total PAH and total toxic equivalence (BaP(eq)) concentrations in the ambient air of a rice field were 7206 ng m⁻³ and 10.3 ng m⁻³, respectively, whereas after the open burning event, they were 376 ng m⁻³ and 1.50 ng m⁻³, respectively. Open burning thus increases total PAH and total BaP(eq) concentrations by 19-fold and 6.8-fold, respectively. During a rice straw open burning event, in the ambient air of a rice field, the mean dry deposition fluxes of total PAHs and total BaP(eq) were 1222 μg m⁻² day⁻¹ and 4.80 μg m⁻² day⁻¹, respectively, which are approximately 60- and 3-fold higher than those during the non-open burning period, respectively. During the non-open burning period, particle-bound PAHs contributed 79.2-84.2% of total dry deposition fluxes (gas + particle) of total PAHs. However, an open burning event increases the contribution to total PAH dry deposition by particle-bound PAHs by up to 85.9-95.5%. The results show that due to the increased amount of PM in the ambient air resulting from rice straw open burning, particle-bound PAHs contributed more to dry deposition fluxes of total PAHs than they do during non-open burning periods. The results show that biomass (rice straw) open burning is an important PAH emission source that significantly increases both PM and PAH concentration levels and PAH dry deposition in ambient air.

Evaluation of the results of simultaneous open rhinoplasty and Abbe flap for the reconstruction of the secondary bilateral cleft and nasal deformity.

PubMed

Eski, Muhitdin; Aykan, Andac; Alhan, Dogan; Zor, Fatih; Isik, Selcuk

2015-06-01

We aimed to evaluate the results of simultaneous rhinoplasty and Abbe flap for the reconstruction of the secondary bilateral cleft and nasal deformity by means of a newly developed software-based method. A total of 16 patients with the bilateral cleft lip nasal deformity received Abbe flap and simultaneous open rhinoplasty between 2004 and 2010. The mean age of the patients was 21 years, and the average follow-up time was 2.4 years. After the open rhinoplasty procedure, the upper lip was reconstructed with the Abbe flap. Preoperative and postoperative photographs that had been taken laterally were evaluated by using Adobe Photoshop(®) CS4 and Adobe InDesign(®) software. The length of the columella and the relative changes of the most anterior point of the upper lip to the vertical plane tangent to the most anterior point of the lower lip were measured in pixels on standardized preoperative and postoperative images. The differences were calculated and compared as a percentage (%). There was no flap loss and associated problems. The measurements of columellar length revealed an average increase of 51.8 ± 11.3%, while the relative change of the most anterior point of the upper lip revealed an average increase of 68.6 ± 11.2%. The results of the treatment modality were successfully evaluated by a newly developed software-based method. Copyright © 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Sources of magnetic fields in recurrent interplanetary streams

NASA Technical Reports Server (NTRS)

Burlaga, L. F.; Behannon, K. W.; Hansen, S. F.; Pneuman, G. W.; Feldman, W. C.

1978-01-01

The paper examines sources of magnetic fields in recurrent streams observed by the Imp 8 and Heos spacecraft at 1 AU and by Mariner 10 en route to Mercury between October 31, 1973 and February 9, 1974, during Carrington rotations 1607-1610. Although most fields and plasmas at 1 AU were related to coronal holes and the magnetic field lines were open in those holes, some of the magnetic fields and plasmas at 1 AU were related to open field line regions on the sun which were not associated with known coronal holes, indicating that open field lines may be more basic than coronal holes as sources of the solar wind. Magnetic field intensities in five equatorial coronal holes, certain photospheric magnetic fields, and the coronal footprints of the sector boundaries on the source surface are characterized.

Cosmonaut Krikalev takes photos in U.S. Laboratory /Destiny module

NASA Image and Video Library

2001-02-11

STS98-E-5138 (11 February 2001) --- Cosmonaut Sergei K. Krikalev, Expedition One flight engineer, takes still photographs onboard the newly opened Destiny laboratory on the International Space Station (ISS). After astronaut William M. (Bill) Shepherd, Expedition One commander, opened the Destiny hatch, he and astronaut Kenneth D. Cockrell (out of frame) ventured inside at 8:38 a.m. (CST), February 11, 2001. As depicted in subsequent digital images in this series, members of both crews went to work quickly inside the new module, activating air systems, fire extinguishers, alarm systems, computers and internal communications. The crew also took some photos and continued equipment transfers from the shuttle to the station.

MS Jones in U.S. Laboratory / Destiny module

NASA Image and Video Library

2001-02-11

STS98-E-5137 (11 February 2001) --- Astronauts Thomas D. Jones (foreground), STS-98 mission specialist, and William M. Shepherd, Expedition One mission commander, participate in an impromptu photo shoot onboard the newly opened Destiny laboratory on the International Space Station (ISS). After Shepherd opened the Destiny hatch, he and astronaut Kenneth D. Cockrell (out of frame) ventured inside at 8:38 a.m. (CST), February 11, 2001. As depicted in subsequent digital images in this series, members of both crews went to work quickly inside the new module, activating air systems, fire extinguishers, alarm systems, computers and internal communications. The crew also took some photos and continued equipment transfers from the shuttle to the station.

Microfilming for Drafting Students

ERIC Educational Resources Information Center

Bass, Ronald E.

1972-01-01

If you have a 35mm camera, an enlarger or filmstrip projector, and developing equipment you can introduce your drafting students to one of the processes used in the newly emerging field of technical communication.'' (Editor)

Widening Access through Openness in Higher Education in the Developing World: A Bourdieusian Field Analysis of Experiences from the National Open University of Nigeria

ERIC Educational Resources Information Center

Olakulehin, Felix Kayode; Singh, Gurmit

2013-01-01

Bourdieu has argued that higher education is a field that reproduces social inequality, thus complicating how openness widens access to higher education in the developing world. Drawing on the experiences of the National Open University of Nigeria (NOUN), this paper critically analyses and evaluates the rationale, approach, difficulties,…

Thermophysical properties of liquid rare earth metals

NASA Astrophysics Data System (ADS)

Thakor, P. B.; Sonvane, Y. A.; Patel, H. P.; Jani, A. R.

2013-06-01

The thermodynamical properties like long wavelength limit S(0), iso-thermal compressibility (χT), thermal expansion coefficient (αV), thermal pressure coefficient (γV), specific heat at constant volume (CV) and specific heat at constant pressure (CP) are calculated for liquid rare earth metals. Our newly constructed parameter free model potential is used to describe the electron ion interaction due to Sarkar et al (S) local field correction function. Lastly, we conclude that our newly constructed model potential is capable to explain the thermophysical properties of liquid rare earth metals.

Strangeness Photoproduction at the BGO-OD Experiment

NASA Astrophysics Data System (ADS)

Jude, T. C.; Alef, S.; Bayadilov, D.; Beck, R.; Becker, M.; Bella, A.; Bielefeldt, P.; Boese, S.; Braghieri, A.; Brinkmann, K.; Cole, P.; Curciarello, F.; De Leo, V.; Di Salvo, R.; Dutz, H.; Elsner, D.; Fantini, A.; Freyermuth, O.; Friedrich, S.; Frommberger, F.; Ganenko, V.; Gervino, G.; Ghio, F.; Giardina, G.; Goertz, S.; Gridnev, A.; Gutz, E.; Hammann, D.; Hannappel, J.; Hartmann, P.; Hillert, W.; Ignatov, A.; Jahn, R.; Joosten, R.; Klein, F.; Koop, K.; Krusche, B.; Lapik, A.; Levi Sandri, P.; Lopatin, I. V.; Mandaglio, G.; Messi, F.; Messi, R.; Metag, V.; Moricciani, D.; Mushkarenkov, A.; Nanova, M.; Nedorezov, V.; Novinskiy, D.; Pedroni, P.; Reitz, B.; Romaniuk, M.; Rostomyan, T.; Rudnev, N.; Scheluchin, G.; Schmieden, H.; Stugelev, A.; Sumachev, V.; Tarakanov, V.; Vegna, V.; Walther, D.; Watts, D.; Zaunick, H.; Zimmermann, T.

BGO-OD is a newly commissioned experiment to investigate the internal structure of the nucleon, using an energy tagged bremsstrahlung photon beam at the ELSA electron facility. The setup consists of a highly segmented BGO calorimeter surrounding the target, with a particle tracking magnetic spectrometer at forward angles. BGO-OD is ideal for investigating meson photoproduction. The extensive physics programme for open strangeness photoproduction is introduced, and preliminary analysis presented.

Exposure to culturally sensitive sexual health information and impact on health literacy: a qualitative study among newly arrived refugee women in Sweden.

PubMed

Svensson, Pia; Carlzén, Katarina; Agardh, Anette

2017-07-01

In Sweden, migrants have poorer sexual and reproductive health compared to the general population. Health literacy, in the form of the cognitive and social skills enabling access to health promoting activities, is often poorer among migrants, partly due to language and cultural barriers. Culturally sensitive health education provides a strategy for enhancing health literacy. Since 2012, specially trained civic and health communicators have provided sexual and reproductive health and rights information to newly arrived refugees in Skåne, Sweden. The aim of this study was to explore how information on sexual and reproductive health and rights was perceived by female recipients and whether being exposed to such information contributed to enhanced sexual and reproductive health and rights literacy. Semi-structured in-depth interviews were conducted with nine women and analysed using qualitative content analysis. Two themes emerged: (1) opening the doors to new understandings of sexual and reproductive health and rights and (2) planting the seed for engagement in sexual and reproductive health and rights issues, illustrating how cultural norms influenced perceptions, but also how information opened up opportunities for challenging these norms. Gender-separate groups may facilitate information uptake, while discussion concerning sexual health norms may benefit from taking place in mixed groups.

Using Participatory Approach to Improve Availability of Spatial Data for Local Government

NASA Astrophysics Data System (ADS)

Kliment, T.; Cetl, V.; Tomič, H.; Lisiak, J.; Kliment, M.

2016-09-01

Nowadays, the availability of authoritative geospatial features of various data themes is becoming wider on global, regional and national levels. The reason is existence of legislative frameworks for public sector information and related spatial data infrastructure implementations, emergence of support for initiatives as open data, big data ensuring that online geospatial information are made available to digital single market, entrepreneurs and public bodies on both national and local level. However, the availability of authoritative reference spatial data linking the geographic representation of the properties and their owners are still missing in an appropriate quantity and quality level, even though this data represent fundamental input for local governments regarding the register of buildings used for property tax calculations, identification of illegal buildings, etc. We propose a methodology to improve this situation by applying the principles of participatory GIS and VGI used to collect observations, update authoritative datasets and verify the newly developed datasets of areas of buildings used to calculate property tax rates issued to their owners. The case study was performed within the district of the City of Požega in eastern Croatia in the summer 2015 and resulted in a total number of 16072 updated and newly identified objects made available online for quality verification by citizens using open source geospatial technologies.

Long-term efficacy and safety of lamotrigine monotherapy in Japanese and South Korean pediatric patients with newly diagnosed typical absence seizures: An open-label extension study.

PubMed

Yasumoto, Sawa; Ohtsuka, Yoko; Sato, Katsuaki; Kurata, Atsuyo; Numachi, Yotaro; Shimizu, Masahiro

2018-05-31

To investigate the efficacy and safety of long-term lamotrigine (LTG) monotherapy in Japanese and South Korean pediatric patients with newly diagnosed typical absence seizures. Six Japanese patients and one South Korean patient were enrolled in the extension phase of the study after completing the 12-week maintenance phase of an open-label clinical study of LTG monotherapy. During the extension phase, patients underwent efficacy and safety evaluation every 12 weeks. Of the seven patients, six patients completed the extension phase. The seizure-free rate confirmed by hyperventilation (HV)-electroencephalography ranged from 71.4% to 100.0% at each visit up to Week 168 of the extension phase. Similar effects were confirmed by HV-clinical signs and seizure diaries. Although no unexpected adverse events were observed, one Japanese patient was withdrawn from the extension phase due to mild drug-related rash developed 842 days after the start of LTG. Although the number of patients is limited, long-term LTG monotherapy appeared to be effective and generally well tolerated in Japanese and South Korean pediatric patients with typical absence seizures. Copyright © 2018 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Study of surface energy budget and test of a newly developed fast photoacoustic spectroscopy based hygrometer in field campaign Szeged (Hungary)

NASA Astrophysics Data System (ADS)

Tatrai, David; Nikov, Daniella; Zsolt Jász, Ervin; Bozóki, Zoltán; Szabó, Gábor; Weidinger, Tamás; András Gyöngyösi, Zénó; Kiss, Melinda; Józsa, János; Simó Diego, Gemma; Cuxart Rodamilans, Joan; Wrenger, Burkhart; Bottyán, Zsolt

2014-05-01

A micrometeorological field measurement campaign dedicated to study the surface energy budget and the structure of the boundary layer focusing on the transient layer forming periods during night-time was organized in the period of 10th of November to 3rd of December 2013 in the nearby of Szeged, Hungary. A temporary micrometeorological measurement station was set up at the coordinates N:46.239943; E:20.089758, approximately 1700 m far from a national meteorology station (N:46.255711; E:20.09052). In the experimental micrometeorological site different types of instruments were installed to measure numerous parameters: standard meteorological measurements (p, T, wet, wind speed and direction at three different levels, relative humidity at two levels and absolute humidity at one level) radiation budget components surface temperature and leaf wetness soil temperature, moisture and heat flux into the deeper soil layer eddy-covariance measurements (t, H, LE CO2) at 3 m level using Campbell open-path IRGA (EC150) system. At the national meteorology station (http://adatok.geo.u-szeged.hu/?lang=eng) besides their standard measurement equipment and measurement routine a SODAR was installed and continuously operated. These ground based measurements were combined with and supported by UAV, quadcopter and tethered balloon based vertical profile measurements of p, T, rh. For this measurement campaign as a modification of a previously developed airborne ready dual channel hygrometer, a fast photoacoustic spectroscopy based hygrometer was developed for absolute humidity measurements. The estimated response time of the system is faster than 15 Hz, which was achieved by the replacement of the data acquisition system and by recording the raw photoacoustic signal sampled at rate of 48 kHz for post-processing. During the campaign this new system was compared to a TDL system commercially available at Li-COR Inc. Besides the testing of the newly developed fast photoacoustic hygrometer the main goal of the present study is the determination of the total energy budget and the accuracy of its closure. Results and consequences of the measurements will be presented.

The newly expanded KSC Visitors Complex features a new ticket plaza, information center, exhibits an

NASA Technical Reports Server (NTRS)

1999-01-01

At the grand opening of the newly expanded KSC Visitor Complex, Center Director Roy Bridges presents Deep Space Nine star Avery Brooks with a plaque, NASA jacket and hat. Brooks narrates the new film Quest for Life at the Visitor Center. Brooks was recognized for his contribution to advancing the public's understanding of NASA and the search for life elsewhere in the universe. The Complex now includes an International Space Station-themed ticket plaza, featuring a structure of overhanging solar panels and astronauts performing assembly tasks, a new foyer, films, and exhibits. The KSC Visitor Complex was inaugurated three decades ago and is now one of the top five tourist attractions in Florida. It is located on S.R. 407, east of I-95, within the Merritt Island National Wildlife Refuge.

The newly expanded KSC Visitors Complex features a new ticket plaza, information center, exhibits an

NASA Technical Reports Server (NTRS)

1999-01-01

At the grand opening of the newly expanded KSC Visitor Complex, Center Director Roy Bridges presents Deep Space Nine star Avery Brooks with a plaque, recognizing his contribution to advancing the public's understanding of NASA and the search for life elsewhere in the universe. Brooks narrates the new film Quest for Life at the Visitor Center. The $ 13 million addition to the Visitor Complex now includes an International Space Station- themed ticket plaza, featuring a structure of overhanging solar panels and astronauts performing assembly tasks, a new information center, films, and exhibits. The KSC Visitor Complex was inaugurated three decades ago and is now one of the top five tourist attractions in Florida. It is located on S.R. 407, east of I-95, within the Merritt Island National Wildlife Refuge.

Correlation electron cyclotron emission diagnostic and improved calculation of turbulent temperature fluctuation levels on ASDEX Upgrade

NASA Astrophysics Data System (ADS)

Creely, A. J.; Freethy, S. J.; Burke, W. M.; Conway, G. D.; Leccacorvi, R.; Parkin, W. C.; Terry, D. R.; White, A. E.

2018-05-01

A newly upgraded correlation electron cyclotron emission (CECE) diagnostic has been installed on the ASDEX Upgrade tokamak and has begun to perform experimental measurements of electron temperature fluctuations. CECE diagnostics measure small amplitude electron temperature fluctuations by correlating closely spaced heterodyne radiometer channels. This upgrade expanded the system from six channels to thirty, allowing simultaneous measurement of fluctuation level radial profiles without repeat discharges, as well as opening up the possibility of measuring radial turbulent correlation lengths. Newly refined statistical techniques have been developed in order to accurately analyze the fluctuation data collected from the CECE system. This paper presents the hardware upgrades for this system and the analysis techniques used to interpret the raw data, as well as measurements of fluctuation spectra and fluctuation level radial profiles.

Uranyl mediated photofootprinting reveals strong E. coli RNA polymerase--DNA backbone contacts in the +10 region of the DeoP1 promoter open complex.

PubMed Central

Jeppesen, C; Nielsen, P E

1989-01-01

Employing a newly developed uranyl photofootprinting technique (Nielsen et al. (1988) FEBS Lett. 235, 122), we have analyzed the structure of the E. coli RNA polymerase deoP1 promoter open complex. The results show strong polymerase DNA backbone contacts in the -40, -10, and most notably in the +10 region. These results suggest that unwinding of the -12 to +3 region of the promoter in the open complex is mediated through polymerase DNA backbone contacts on both sides of this region. The pattern of bases that are hyperreactive towards KMnO4 or uranyl within the -12 to +3 region furthermore argues against a model in which this region is simply unwound and/or single stranded. The results indicate specific protein contacts and/or a fixed DNA conformation within the -12 to +3 region. Images PMID:2503811

Full open-framework batteries for stationary energy storage

NASA Astrophysics Data System (ADS)

Pasta, Mauro; Wessells, Colin D.; Liu, Nian; Nelson, Johanna; McDowell, Matthew T.; Huggins, Robert A.; Toney, Michael F.; Cui, Yi

2014-01-01

New types of energy storage are needed in conjunction with the deployment of renewable energy sources and their integration with the electrical grid. We have recently introduced a family of cathodes involving the reversible insertion of cations into materials with the Prussian Blue open-framework crystal structure. Here we report a newly developed manganese hexacyanomanganate open-framework anode that has the same crystal structure. By combining it with the previously reported copper hexacyanoferrate cathode we demonstrate a safe, fast, inexpensive, long-cycle life aqueous electrolyte battery, which involves the insertion of sodium ions. This high rate, high efficiency cell shows a 96.7% round trip energy efficiency when cycled at a 5C rate and an 84.2% energy efficiency at a 50C rate. There is no measurable capacity loss after 1,000 deep-discharge cycles. Bulk quantities of the electrode materials can be produced by a room temperature chemical synthesis from earth-abundant precursors.

Efficient Sample Tracking With OpenLabFramework

PubMed Central

List, Markus; Schmidt, Steffen; Trojnar, Jakub; Thomas, Jochen; Thomassen, Mads; Kruse, Torben A.; Tan, Qihua; Baumbach, Jan; Mollenhauer, Jan

2014-01-01

The advance of new technologies in biomedical research has led to a dramatic growth in experimental throughput. Projects therefore steadily grow in size and involve a larger number of researchers. Spreadsheets traditionally used are thus no longer suitable for keeping track of the vast amounts of samples created and need to be replaced with state-of-the-art laboratory information management systems. Such systems have been developed in large numbers, but they are often limited to specific research domains and types of data. One domain so far neglected is the management of libraries of vector clones and genetically engineered cell lines. OpenLabFramework is a newly developed web-application for sample tracking, particularly laid out to fill this gap, but with an open architecture allowing it to be extended for other biological materials and functional data. Its sample tracking mechanism is fully customizable and aids productivity further through support for mobile devices and barcoded labels. PMID:24589879

Construction of Gallium Point at NMIJ

NASA Astrophysics Data System (ADS)

Widiatmo, J. V.; Saito, I.; Yamazawa, K.

2017-03-01

Two open-type gallium point cells were fabricated using ingots whose nominal purities are 7N. Measurement systems for the realization of the melting point of gallium using these cells were built. The melting point of gallium is repeatedly realized by means of the measurement systems for evaluating the repeatability. Measurements for evaluating the effect of hydrostatic pressure coming from the molten gallium existing during the melting process and the effect of gas pressure that fills the cell were also performed. Direct cell comparisons between those cells were conducted. This comparison was aimed to evaluate the consistency of each cell, especially related to the nominal purity. Direct cell comparison between the open-type and the sealed-type gallium point cell was also conducted. Chemical analysis was conducted using samples extracted from ingots used in both the newly built open-type gallium point cells, from which the effect of impurities in the ingot was evaluated.

Full open-framework batteries for stationary energy storage.

PubMed

Pasta, Mauro; Wessells, Colin D; Liu, Nian; Nelson, Johanna; McDowell, Matthew T; Huggins, Robert A; Toney, Michael F; Cui, Yi

2014-01-01

New types of energy storage are needed in conjunction with the deployment of renewable energy sources and their integration with the electrical grid. We have recently introduced a family of cathodes involving the reversible insertion of cations into materials with the Prussian Blue open-framework crystal structure. Here we report a newly developed manganese hexacyanomanganate open-framework anode that has the same crystal structure. By combining it with the previously reported copper hexacyanoferrate cathode we demonstrate a safe, fast, inexpensive, long-cycle life aqueous electrolyte battery, which involves the insertion of sodium ions. This high rate, high efficiency cell shows a 96.7% round trip energy efficiency when cycled at a 5C rate and an 84.2% energy efficiency at a 50C rate. There is no measurable capacity loss after 1,000 deep-discharge cycles. Bulk quantities of the electrode materials can be produced by a room temperature chemical synthesis from earth-abundant precursors.

Waiting for Water

ERIC Educational Resources Information Center

Lamson-Nussbaum, Jorie

2013-01-01

The author waits in the hot and oppressive air while dust devils are born and die over the newly plowed field. It is a dry spring and she prays for rain. The lupine beans withered to dry threads last week and the corn that sprouted in a green haze over the north field is turning to brown paper. However, driving north, the author discovers the Rum…

Stand dynamics of an old-field longleaf pine stand following herbicide application, poor survival, and subsequent replanting

Treesearch

E. David Dickens; Bryan C. McElvany; David J. Moorhead; Philip R. Torrance; P. Mark Crosby

2010-01-01

A study area in Emanuel County, GA installed to discern the effectiveness of various herbicides over newly planted (December 1999) longleaf pine (Pinus palustris Mill.) seedlings on an old-field site. Survival and height growth data after herbicide treatment indicate that the early (April 7, 2000) Oust+Velpar L herbicide treatment gave greater...

Individual consistency in the behaviors of newly-settled reef fish

PubMed Central

Meekan, Mark G.; McCormick, Mark I.

2015-01-01

Flexibility in behavior is advantageous for organisms that transition between stages of a complex life history. However, various constraints can set limits on plasticity, giving rise to the existence of personalities that have associated costs and benefits. Here, we document a field and laboratory experiment that examines the consistency of measures of boldness, activity, and aggressive behavior in the young of a tropical reef fish, Pomacentrus amboinensis (Pomacentridae) immediately following their transition between pelagic larval and benthic juvenile habitats. Newly-settled fish were observed in aquaria and in the field on replicated patches of natural habitat cleared of resident fishes. Seven behavioral traits representing aspects of boldness, activity and aggression were monitored directly and via video camera over short (minutes), medium (hours), and long (3 days) time scales. With the exception of aggression, these behaviors were found to be moderately or highly consistent over all time scales in both laboratory and field settings, implying that these fish show stable personalities within various settings. Our study is the first to examine the temporal constancy of behaviors in both field and laboratory settings in over various time scales at a critically important phase during the life cycle of a reef fish. PMID:26020013

Individual consistency in the behaviors of newly-settled reef fish.

PubMed

White, James R; Meekan, Mark G; McCormick, Mark I

2015-01-01

Flexibility in behavior is advantageous for organisms that transition between stages of a complex life history. However, various constraints can set limits on plasticity, giving rise to the existence of personalities that have associated costs and benefits. Here, we document a field and laboratory experiment that examines the consistency of measures of boldness, activity, and aggressive behavior in the young of a tropical reef fish, Pomacentrus amboinensis (Pomacentridae) immediately following their transition between pelagic larval and benthic juvenile habitats. Newly-settled fish were observed in aquaria and in the field on replicated patches of natural habitat cleared of resident fishes. Seven behavioral traits representing aspects of boldness, activity and aggression were monitored directly and via video camera over short (minutes), medium (hours), and long (3 days) time scales. With the exception of aggression, these behaviors were found to be moderately or highly consistent over all time scales in both laboratory and field settings, implying that these fish show stable personalities within various settings. Our study is the first to examine the temporal constancy of behaviors in both field and laboratory settings in over various time scales at a critically important phase during the life cycle of a reef fish.

Poster - 23: Dosimetric Characterization and Transferability of an Accessory Mounted Mini-Beam Collimator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, William; Crewson, Cody; Alexander, Andrew

Objective: The dosimetric characterization of an accessory-mounted mini-beam collimator across three beam matched linear accelerators. Materials and Methods: Percent depth dose and profiles were measured for the open and mini-beam collimated fields. The average beam quality and peak-to-valley dose ratio (PVDR), the ratio of average peak dose to average valley dose, were obtained from these measurements. The open field relative output and the mini-beam collimator factor, the ratio of the mini-beam dose to open field dose at the beam center, were measured for square fields of side 2, 3, 4, and 5 cm. Mini-beam output as a function of collimatormore » inclination angle relative to the central axis was also investigated. Results and Discussion: Beam quality for both the open and mini-beam collimated fields agreed across all linacs to within ±1.0%. The PVDR was found to vary by up to ±6.6% from the mean. For the 2, 3, and 4 cm fields the average open field relative output with respect to the 5 cm field was 0.874±0.4%, 0.921±0.3%, and 0.962±0.1%. The average collimator factors were 0.450±3.9%, 0.443±3.9%, 0.438±3.9%, and 0.434±3.9%. A decrease in collimator factor greater than 7% was found for an inclination angle change of 0.09°. Conclusion: The mini-beam collimator has revealed a difference between the three linacs not apparent in the open field data, yet transferability can still be attained through thorough dosimetric characterization.« less

A study of the electric field in an open magnetospheric model

NASA Technical Reports Server (NTRS)

Stern, D. P.

1973-01-01

Recently, Svalgaard and Heppner reported two separate features of the polar electromagnetic field that correlate with the dawn-dusk component of the interplanetary magnetic field. This work attempts to explain these findings in terms of properties of the open magnetosphere. The topology and qualitative properties of the open magnetosphere are first studied by means of a simple model, consisting of a dipole in a constant field. Many such properties are found to depend on the separation line, a curve connecting neutral points and separating different field line regimes. In the simple model it turns out that the electric field in the central polar cap tends to point from dawn to dusk for a wide variety of external fields, but, near the boundary of the polar cap, electric equipotentials are deformed into crescents.

Interchange Slip-Running Reconnection and Sweeping SEP-Beams

NASA Technical Reports Server (NTRS)

Masson, S.; Aulanier, G.; Pariat, E.; Klein, K.-L.

2011-01-01

We present a new model to explain how particles, accelerated at a reconnection site that is not magnetically connected to the Earth, could eventually propagate along the well-connected open flux tube. Our model is based on the results of a low-beta resistive magnetohydrodynamics simulation of a three-dimensional line-tied and initially current-free bipole, that is embedded in a non-uniform open potential field. The topology of this configuration is that of an asymmetric coronal null-point, with a closed fan surface and an open outer spine. When driven by slow photospheric shearing motions, field lines, initially fully anchored below the fan dome, reconnect at the null point, and jump to the open magnetic domain. This is the standard interchange mode as sketched and calculated in 2D. The key result in 3D is that, reconnected open field lines located in the vicinity of the outer spine, keep reconnecting continuously, across an open quasi-separatrix layer, as previously identified for non-open-null-point reconnection. The apparent slipping motion of these field lines leads to form an extended narrow magnetic flux tube at high altitude. Because of the slip-running reconnection, we conjecture that if energetic particles would be travelling through, or be accelerated inside, the diffusion region, they would be successively injected along continuously reconnecting field lines that are connected farther and farther from the spine. At the scale of the full Sun, owing to the super-radial expansion of field lines below 3 solar radius, such energetic particles could easily be injected in field lines slipping over significant distances, and could eventually reach the distant flux tube that is well-connected to the Earth.

Open magnetic fields in active regions

NASA Technical Reports Server (NTRS)

Svestka, Z.; Solodyna, C. V.; Howard, R.; Levine, R. H.

1977-01-01

Soft X-ray images and magnetograms of several active regions and coronal holes are examined which support the interpretation that some of the dark X-ray gaps seen between interconnecting loops and inner cores of active regions are foot points of open field lines inside the active regions. Characteristics of the investigated dark gaps are summarized. All the active regions with dark X-ray gaps at the proper place and with the correct polarity predicted by global potential extrapolation of photospheric magnetic fields are shown to be old active regions, indicating that field opening is accomplished only in a late phase of active-region development. It is noted that some of the observed dark gaps probably have nothing in common with open fields, but are either due to the decreased temperature in low-lying portions of interconnecting loops or are the roots of higher and less dense or cooler loops.

Relationship between Birkeland current regions, particle precipitation, and electric fields

NASA Technical Reports Server (NTRS)

De La Beaujardiere, O.; Watermann, J.; Newell, P.; Rich, F.

1993-01-01

The relationship of the large-scale dayside Birkeland currents to large-scale particle precipitation patterns, currents, and convection is examined using DMSP and Sondrestrom radar observations. It is found that the local time of the mantle currents is not limited to the longitude of the cusp proper, but covers a larger local time extent. The mantle currents flow entirely on open field lines. About half of region 1 currents flow on open field lines, consistent with the assumption that the region 1 currents are generated by the solar wind dynamo and flow within the surface that separates open and closed field lines. More than 80 percent of the Birkeland current boundaries do not correspond to particle precipitation boundaries. Region 2 currents extend beyond the plasma sheet poleward boundary; region 1 currents flow in part on open field lines; mantle currents and mantle particles are not coincident. On most passes when a triple current sheet is observed, the convection reversal is located on closed field lines.

Bacterial activity in sea ice and open water of the Weddell Sea, Antarctica: A microautoradiographic study.

PubMed

Grossmann, S

1994-07-01

Metabolic activity of bacteria was investigated in open water, newly forming sea ice, and successive stages of pack ice in the Weddell Sea. Microautoradiography, using [(3)H]leucine as substrate, was compared with incorporation rates of [(3)H]leucine into proteins. Relation of [(3)H]leucine incorporation to the biomass of active bacteria provides information about changes of specific metabolic activity of cells. During a phytoplankton bloom in an ice-free, stratified water column, total numbers of bacteria in the euphotic zone averaged 2.3 × 10(5) ml(-1), but only about 13% showed activity via leucine uptake. Growth rate of the active bacteria was estimated as 0.3-0.4 days(-1). Total cell concentration of bacteria in 400 m depth was 6.6 × 10(4) ml(-1). Nearly 50% of these cells were active, although biomass production and specific growth rate were only about one-tenth that of the surface populations. When sea ice was forming in high concentrations of phytoplankton, bacterial biomass in the newly formed ice was 49.1 ng C ml(-1), exceeding that in open water by about one order of magnitude. Attachment of large bacteria to algal cells seems to cause their enrichment in the new ice, since specific bacterial activity was reduced during ice formation, and enrichment of bacteria was not observed when ice formed at low algal concentration. During growth of pack ice, biomass of bacteria increased within the brine channel system. Specific activity was still reduced at these later stages of ice development, and percentages of active cells were as low as 3-5%. In old, thick pack ice, bacterial activity was high and about 30% of cells were active. However, biomass-specific activity of bacteria remained significantly lower than that in open water. It is concluded that bacterial assemblages different to those of open water developed within the ice and were dominated by bacteria with lower average metabolic activity than those of ice-free water.

[Predicting the probability of development and progression of primary open angle glaucoma by regression modeling].

PubMed

Likhvantseva, V G; Sokolov, V A; Levanova, O N; Kovelenova, I V

2018-01-01

Prediction of the clinical course of primary open-angle glaucoma (POAG) is one of the main directions in solving the problem of vision loss prevention and stabilization of the pathological process. Simple statistical methods of correlation analysis show the extent of each risk factor's impact, but do not indicate the total impact of these factors in personalized combinations. The relationships between the risk factors is subject to correlation and regression analysis. The regression equation represents the dependence of the mathematical expectation of the resulting sign on the combination of factor signs. To develop a technique for predicting the probability of development and progression of primary open-angle glaucoma based on a personalized combination of risk factors by linear multivariate regression analysis. The study included 66 patients (23 female and 43 male; 132 eyes) with newly diagnosed primary open-angle glaucoma. The control group consisted of 14 patients (8 male and 6 female). Standard ophthalmic examination was supplemented with biochemical study of lacrimal fluid. Concentration of matrix metalloproteinase MMP-2 and MMP-9 in tear fluid in both eyes was determined using 'sandwich' enzyme-linked immunosorbent assay (ELISA) method. The study resulted in the development of regression equations and step-by-step multivariate logistic models that can help calculate the risk of development and progression of POAG. Those models are based on expert evaluation of clinical and instrumental indicators of hydrodynamic disturbances (coefficient of outflow ease - C, volume of intraocular fluid secretion - F, fluctuation of intraocular pressure), as well as personalized morphometric parameters of the retina (central retinal thickness in the macular area) and concentration of MMP-2 and MMP-9 in the tear film. The newly developed regression equations are highly informative and can be a reliable tool for studying of the influence vector and assessment of pathogenic potential of the independent risk factors in specific personalized combinations.

Solar Open Flux Migration from Pole to Pole: Magnetic Field Reversal.

PubMed

Huang, G-H; Lin, C-H; Lee, L C

2017-08-25

Coronal holes are solar regions with low soft X-ray or low extreme ultraviolet intensities. The magnetic fields from coronal holes extend far away from the Sun, and thus they are identified as regions with open magnetic field lines. Coronal holes are concentrated in the polar regions during the sunspot minimum phase, and spread to lower latitude during the rising phase of solar activity. In this work, we identify coronal holes with outward and inward open magnetic fluxes being in the opposite poles during solar quiet period. We find that during the sunspot rising phase, the outward and inward open fluxes perform pole-to-pole trans-equatorial migrations in opposite directions. The migration of the open fluxes consists of three parts: open flux areas migrating across the equator, new open flux areas generated in the low latitude and migrating poleward, and new open flux areas locally generated in the polar region. All three components contribute to the reversal of magnetic polarity. The percentage of contribution from each component is different for different solar cycle. Our results also show that the sunspot number is positively correlated with the lower-latitude open magnetic flux area, but negatively correlated with the total open flux area.

The Evolution of Open Magnetic Flux Driven by Photospheric Dynamics

NASA Technical Reports Server (NTRS)

Linker, Jon A.; Lionello, Roberto; Mikic, Zoran; Titov, Viacheslav S.; Antiochos, Spiro K.

2010-01-01

The coronal magnetic field is of paramount importance in solar and heliospheric physics. Two profoundly different views of the coronal magnetic field have emerged. In quasi-steady models, the predominant source of open magnetic field is in coronal holes. In contrast, in the interchange model, the open magnetic flux is conserved, and the coronal magnetic field can only respond to the photospheric evolution via interchange reconnection. In this view the open magnetic flux diffuses through the closed, streamer belt fields, and substantial open flux is present in the streamer belt during solar minimum. However, Antiochos and co-workers, in the form of a conjecture, argued that truly isolated open flux cannot exist in a configuration with one heliospheric current sheet (HCS) - it will connect via narrow corridors to the polar coronal hole of the same polarity. This contradicts the requirements of the interchange model. We have performed an MHD simulation of the solar corona up to 20R solar to test both the interchange model and the Antiochos conjecture. We use a synoptic map for Carrington Rotation 1913 as the boundary condition for the model, with two small bipoles introduced into the region where a positive polarity extended coronal hole forms. We introduce flows at the photospheric boundary surface to see if open flux associated with the bipoles can be moved into the closed-field region. Interchange reconnection does occur in response to these motions. However, we find that the open magnetic flux cannot be simply injected into closed-field regions - the flux eventually closes down and disconnected flux is created. Flux either opens or closes, as required, to maintain topologically distinct open and closed field regions, with no indiscriminate mixing of the two. The early evolution conforms to the Antiochos conjecture in that a narrow corridor of open flux connects the portion of the coronal hole that is nearly detached by one of the bipoles. In the later evolution, a detached coronal hole forms, in apparent violation of the Antiochos conjecture. Further investigation reveals that this detached coronal hole is actually linked to the extended coronal hole by a separatrix footprint on the photosphere of zero width. Therefore, the essential idea of the conjecture is preserved, if we modify it to state that coronal holes in the same polarity region are always linked, either by finite width corridors or separatrix footprints. The implications of these results for interchange reconnection and the sources of the slow solar wind are briefly discussed.

The Evolution of Open Magnetic Flux Driven by Photospheric Dynamics

NASA Astrophysics Data System (ADS)

Linker, Jon A.; Lionello, Roberto; Mikić, Zoran; Titov, Viacheslav S.; Antiochos, Spiro K.

2011-04-01

The coronal magnetic field is of paramount importance in solar and heliospheric physics. Two profoundly different views of the coronal magnetic field have emerged. In quasi-steady models, the predominant source of open magnetic field is in coronal holes. In contrast, in the interchange model, the open magnetic flux is conserved, and the coronal magnetic field can only respond to the photospheric evolution via interchange reconnection. In this view, the open magnetic flux diffuses through the closed, streamer belt fields, and substantial open flux is present in the streamer belt during solar minimum. However, Antiochos and coworkers, in the form of a conjecture, argued that truly isolated open flux cannot exist in a configuration with one heliospheric current sheet—it will connect via narrow corridors to the polar coronal hole of the same polarity. This contradicts the requirements of the interchange model. We have performed an MHD simulation of the solar corona up to 20 R sun to test both the interchange model and the Antiochos conjecture. We use a synoptic map for Carrington rotation 1913 as the boundary condition for the model, with two small bipoles introduced into the region where a positive polarity extended coronal hole forms. We introduce flows at the photospheric boundary surface to see if open flux associated with the bipoles can be moved into the closed-field region. Interchange reconnection does occur in response to these motions. However, we find that the open magnetic flux cannot be simply injected into closed-field regions—the flux eventually closes down and disconnected flux is created. Flux either opens or closes, as required, to maintain topologically distinct open- and closed-field regions, with no indiscriminate mixing of the two. The early evolution conforms to the Antiochos conjecture in that a narrow corridor of open flux connects the portion of the coronal hole that is nearly detached by one of the bipoles. In the later evolution, a detached coronal hole forms, in apparent violation of the Antiochos conjecture. Further investigation reveals that this detached coronal hole is actually linked to the extended coronal hole by a separatrix footprint on the photosphere of zero width. Therefore, the essential idea of the conjecture is preserved, if we modify it to state that coronal holes in the same polarity region are always linked, either by finite width corridors or separatrix footprints. The implications of these results for interchange reconnection and the sources of the slow solar wind are briefly discussed.

Parallel inhomogeneity and the Alfven resonance. 1: Open field lines

NASA Technical Reports Server (NTRS)

Hansen, P. J.; Harrold, B. G.

1994-01-01

In light of a recent demonstration of the general nonexistence of a singularity at the Alfven resonance in cold, ideal, linearized magnetohydrodynamics, we examine the effect of a small density gradient parallel to uniform, open ambient magnetic field lines. To lowest order, energy deposition is quantitatively unaffected but occurs continuously over a thickened layer. This effect is illustrated in a numerical analysis of a plasma sheet boundary layer model with perfectly absorbing boundary conditions. Consequences of the results are discussed, both for the open field line approximation and for the ensuing closed field line analysis.

Stressors of newly graduated nurses in Shanghai paediatric hospital: a qualitative study.

PubMed

Hu, Yun; Zhang, Yaqing; Shen, Nanping; Wu, Juemin; Wu, Jia; Malmedal, Wenche K

2017-04-01

To identify stressors of newly graduated paediatric nurses at a children's hospital in Shanghai, China. Stress is an international phenomenon in nursing generally, but little is known about its effect on new paediatric nurses at the Shanghai paediatric hospital. Participants in this research were 25 newly graduated paediatric nurses. Their behaviours and perceptions were explored by field observations and interviews. Findings indicated that participants experienced numerous stressors: low work status, insufficient professional competence, heavy workload, inadequate supportive systems and uncertainty of career development. The results of the present study provide useful information for administrators to develop and improve postgraduate programmes to support novice paediatric nurses. Our research highlights the importance of identifying the stressors of new paediatric nurses in the light of a serious nurse shortage and an increasing birth rate. © 2016 John Wiley & Sons Ltd.

MAVEN observations of complex magnetic field configuration in the Martian magnetotail

NASA Astrophysics Data System (ADS)

DiBraccio, G. A.; Luhmann, J. G.; Curry, S.; Espley, J. R.; Gruesbeck, J.; Xu, S.; Mitchell, D. L.; Soobiah, Y. I. J.; Connerney, J. E. P.; Dong, C.; Harada, Y.; Ruhunusiri, S.; Halekas, J. S.; Hara, T.; Ma, Y.; Brain, D.; Jakosky, B. M.

2017-12-01

The magnetosphere of Mars has attributes of both induced and intrinsic magnetospheres, forming as a result of direct solar wind interaction with the planet's upper atmosphere and local crustal magnetic fields. Magnetic reconnection is able to occur between the draped interplanetary magnetic field (IMF) and closed crustal magnetic fields, creating an open field topology with one end attached to the planet and the other flowing in the solar wind. For this reason, the Martian magnetotail becomes a complex menagerie of various field topologies that may contribute to atmospheric escape to space. We explore these magnetic topologies in the Martian magnetotail using a combination of observations from the the Mars Atmosphere Volatile EvolutioN (MAVEN) spacecraft along with magnetohydrodynamic (MHD) simulations. Preliminary MHD results suggest that the central tail contains two lobes composed of open crustal fields, which are twisted by roughly 45°, either clockwise or counterclockwise from the ecliptic plane, in response to the east-west component of the IMF. These simulated open-field lobes are enveloped by an induced comet-like tail formed by the draped IMF. Using two Earth years of data, we analyze MAVEN Magnetometer and Solar Wind Ion Analyzer (SWIA) measurements to assess the tail magnetic field configuration as a function of IMF orientation. We infer, through data-model comparisons, that the open-field tail lobes are likely a result of reconnection between the crustal fields and the IMF. The open topology of these fields may in fact contribute to atmospheric loss to space. This investigation confirms that the Martian magnetotail is a hybrid configuration between intrinsic and induced magnetospheres, shifting the paradigm of Mars' magnetosphere as we have understood it thus far.

Interference effect as resonance killer of newly observed charmoniumlike states Y(4320) and Y(4390)

NASA Astrophysics Data System (ADS)

Chen, Dian-Yong; Liu, Xiang; Matsuki, Takayuki

2018-02-01

In this letter, we decode the newly observed charmoniumlike states, Y(4320) and Y(4390), by introducing interference effect between ψ (4160) and ψ (4415), which plays a role of resonance killer for Y(4320) and Y(4390). It means that two newly reported charmoniumlike states are not genuine resonances, according to which we can naturally explain why two well-established charmonia ψ (4160) and ψ (4415) are missing in the cross sections of e^+e^- → π ^+ π ^- J/ψ and π ^+ π ^- h_c simultaneously. To well describe the detailed data of these cross sections around √{s}=4.2 GeV, our study further illustrates that a charmoniumlike structure Y(4220) must be introduced. As a charmonium, Y(4220) should dominantly decay into its open-charm channel e^+e^- → D^0 π ^+ D^{*-}, which provides an extra support to ψ (4S) assignment to Y(4220). In fact, this interference effect introduced to explain Y(4320) and Y(4390) gives a typical example of non-resonant explanations to the observed XYZ states, which should be paid more attention especially before identifying the observed XYZ states as genuine resonances.

The "demise" of diagnostic and research ocular pathology: temporary or forever?

PubMed

Apple, David J; Werner, Liliana; Mamalis, Nick; Olson, Randall J

2003-01-01

Several authorities have documented a significant decrease in support for modern eye pathology/pathology research laboratories. Indeed, many laboratories have closed or suffered marked cutbacks. The purpose of this report is to ask why this is so and to seek a possible means for reversing this trend. Observations from the senior author's experience and a case from author's facility are analyzed. There are several reasons for ocular pathologists' difficulties, such as financial problems, lack of vision, personality conflicts, and problems with the departmental administration. Until recently, most research and development in several subspecialty fields of ophthalmology, including biodevices research, has been done primarily by engineers and in-house workers in industry. This precludes proper independent, nonbiased control and guidance from academia. Most ocular pathologists have not participated in this relatively new and wide-open field. We suggest a new realm of activity for today's newly trained ocular pathologists. Based on personal experience of two decades of fruitful collaboration with industry, we believe that ocular pathologists are uniquely trained to apply their expertise to various new fields of research that most pathologists today have not utilized. An important example is research on clinicopathological aspects of implantable biodevices. In addition, support and oversight should be provided by the major ophthalmic societies, such as the American Academy of Ophthalmology, in order to retain (even regain) control over this field. This is mandatory in order to control the safety and efficacy of new drugs and devices being introduced almost daily. Only then can clear differentiation between profit and patient welfare be achieved as potentially dangerous devices and techniques are let loose on the market. The field of "routine, descriptive" eye pathology is severely wounded and will return only in an attenuated fashion. In general, full-time support for ocular pathologists will not be possible unless they seek extra support from the private sector, engage in a concurrent clinical practice, or are supported by an endowed chair (a wonderful alternative).

The "demise" of diagnostic and research ocular pathology: temporary or forever?

PubMed Central

Apple, David J; Werner, Liliana; Mamalis, Nick; Olson, Randall J

2003-01-01

PURPOSE: Several authorities have documented a significant decrease in support for modern eye pathology/pathology research laboratories. Indeed, many laboratories have closed or suffered marked cutbacks. The purpose of this report is to ask why this is so and to seek a possible means for reversing this trend. METHODS: Observations from the senior author's experience and a case from author's facility are analyzed. RESULTS: There are several reasons for ocular pathologists' difficulties, such as financial problems, lack of vision, personality conflicts, and problems with the departmental administration. Until recently, most research and development in several subspecialty fields of ophthalmology, including biodevices research, has been done primarily by engineers and in-house workers in industry. This precludes proper independent, nonbiased control and guidance from academia. Most ocular pathologists have not participated in this relatively new and wide-open field. CONCLUSIONS: We suggest a new realm of activity for today's newly trained ocular pathologists. Based on personal experience of two decades of fruitful collaboration with industry, we believe that ocular pathologists are uniquely trained to apply their expertise to various new fields of research that most pathologists today have not utilized. An important example is research on clinicopathological aspects of implantable biodevices. In addition, support and oversight should be provided by the major ophthalmic societies, such as the American Academy of Ophthalmology, in order to retain (even regain) control over this field. This is mandatory in order to control the safety and efficacy of new drugs and devices being introduced almost daily. Only then can clear differentiation between profit and patient welfare be achieved as potentially dangerous devices and techniques are let loose on the market. The field of "routine, descriptive" eye pathology is severely wounded and will return only in an attenuated fashion. In general, full-time support for ocular pathologists will not be possible unless they seek extra support from the private sector, engage in a concurrent clinical practice, or are supported by an endowed chair (a wonderful alternative). PMID:14971571

JPRS Report China

DTIC Science & Technology

1990-02-12

military support for the Nicaraguan antigovernment (Contra) forces, generating hope that the " fast knot" in U.S.-Nicaraguan relations can be untied...outpaced the public portion. There is no need to worry no matter how much faster it is growing. What we must be concerned with is not how fast it is...nonferrous metals were smaller. Some that only had a few days of production capacity worked intermittently . Some of the larger, newly opened enterprises

Adaptive and maladaptive responses in skin: mild heat exposure protects against UVB-induced photoaging in mice.

PubMed

Haarmann-Stemmann, Thomas; Boege, Fritz; Krutmann, Jean

2013-04-01

In this issue, Matsuda et al. demonstrate the protective effect of mild heat preconditioning on UVB-induced photoaging in SKH-1 hairless mice. Mild heat exposure stimulates the upregulation of HSP70 chaperones, which inhibit the activities of matrix-degenerating enzymes, thereby avoiding wrinkle formation. This newly identified heat-mediated process of adaptation to UVB radiation exposure opens new opportunities to slow extrinsic skin aging.

CAST: a new program package for the accurate characterization of large and flexible molecular systems.

PubMed

Grebner, Christoph; Becker, Johannes; Weber, Daniel; Bellinger, Daniel; Tafipolski, Maxim; Brückner, Charlotte; Engels, Bernd

2014-09-15

The presented program package, Conformational Analysis and Search Tool (CAST) allows the accurate treatment of large and flexible (macro) molecular systems. For the determination of thermally accessible minima CAST offers the newly developed TabuSearch algorithm, but algorithms such as Monte Carlo (MC), MC with minimization, and molecular dynamics are implemented as well. For the determination of reaction paths, CAST provides the PathOpt, the Nudge Elastic band, and the umbrella sampling approach. Access to free energies is possible through the free energy perturbation approach. Along with a number of standard force fields, a newly developed symmetry-adapted perturbation theory-based force field is included. Semiempirical computations are possible through DFTB+ and MOPAC interfaces. For calculations based on density functional theory, a Message Passing Interface (MPI) interface to the Graphics Processing Unit (GPU)-accelerated TeraChem program is available. The program is available on request. Copyright © 2014 Wiley Periodicals, Inc.

47 CFR 2.1053 - Measurements required: Field strength of spurious radiation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... operation. Curves or equivalent data shall be supplied showing the magnitude of each harmonic and other.... For equipment operating on frequencies below 890 MHz, an open field test is normally required, with... either impractical or impossible to make open field measurements (e.g. a broadcast transmitter installed...

Development and characterization of neutralizing monoclonal antibodies against canine distemper virus hemagglutinin protein.

PubMed

Bi, Zhenwei; Xia, Xingxia; Wang, Yongshan; Mei, Yongjie

2015-04-01

Canine distemper virus (CDV) causes a serious multisystemic disease in dogs and other carnivora. Hemagglutinin (H) protein-specific antibodies are mainly responsible for protective immunity against CDV infection. In the present study, six neutralizing MAbs to the H protein of CDV were newly obtained and characterized by immunizing BALB/c mice with a recent Chinese field isolate. Competitive binding inhibition assay revealed that they recognized four distinct antigenic regions of the H protein. Immunofluorescence assay and western blotting showed that all MAbs recognize the conformational rather than the linear epitopes of the H protein. Furthermore, in immunofluorescence and virus neutralization assays, two of the MAbs were found to react only with the recent Chinese field isolate and not with older CDV strains, including vaccine strain Onderstepoort, indicating there are neutralization-related antigenic variations between the recent Chinese field isolate and the older CDV strains examined in this study. The newly established MAbs are useful for differentiating the expanding CDV strains and could be used in immunotherapy and immunodiagnosis against infection with CDV. © 2015 The Societies and Wiley Publishing Asia Pty Ltd.

Analysis of the Suspended H-Waveguide and Other Related Dielectric Waveguide Structures.

DTIC Science & Technology

1983-01-01

energy is concentrated in the disc. In the substrate regions, the fields decay extremely fast. Consequently, the removal of the dielectric substrates...ado re erse ide i f ne oeeary e d IdO tif’ I V Week 110m mke ) 0 In this thesis, the field and propagation characceristicshof’many dielectric waveguide...propagation co*stants and the field distribu- tions of a newly developed suspended H-woveguide based on the mode matching techniques is described. The d

Navajo minettes in the Cerros de las Mujeres, New Mexico

NASA Astrophysics Data System (ADS)

Vaniman, D.; Laughlin, A. W.; Gladney, E. S.

1985-06-01

The Cerros de las Mujeres in west-central New Mexico are three mafic minette plugs that should be considered part of the Navajo volcanic fields on the central Colorado Plateau. This newly recognized occurrence extends the Navajo volcanic fields to the southeastern margin of the Colorado Plateau, within 45 km of the extensional tectonic setting in which the Mogollon ash-flow tuff cauldrons occur. The Cerros de las Mujeres provide additional evidence for contemporaneous sodic and potassic volcanism within the Navajo volcanic fields.

On the Helicity of Open Magnetic Fields

NASA Astrophysics Data System (ADS)

Prior, C.; Yeates, A. R.

2014-06-01

We reconsider the topological interpretation of magnetic helicity for magnetic fields in open domains, and relate this to the relative helicity. Specifically, our domains stretch between two parallel planes, and each of these ends may be magnetically open. It is demonstrated that, while the magnetic helicity is gauge-dependent, its value in any gauge may be physically interpreted as the average winding number among all pairs of field lines with respect to some orthonormal frame field. In fact, the choice of gauge is equivalent to the choice of reference field in the relative helicity, meaning that the magnetic helicity is no less physically meaningful. We prove that a particular gauge always measures the winding with respect to a fixed frame, and propose that this is normally the best choice. For periodic fields, this choice is equivalent to measuring relative helicity with respect to a potential reference field. However, for aperiodic fields, we show that the potential field can be twisted. We prove by construction that there always exists a possible untwisted reference field.

A study of the electric field in an open magnetospheric model

NASA Technical Reports Server (NTRS)

Stern, D. P.

1972-01-01

The qualitative properties of an open magnetosphere and its electric field are examined and compared to a simple model of a dipole in a constant field and to actual observations. Many of these properties are found to depend on the separatrix, a curve connecting neutral points and separating different field-line regimes. In the simple model, the electric field in the central polar cap tends to point from dawn to dusk for a wide choice of external fields. Near the boundary of the polar cap electric equipotentials curve and become crescent-shaped, which may explain the correlation of polar magnetic variations with the azimuthal component of the interplanetary magnetic field, reported by Svalgaard. Modifications expected to occur in the actual magnetosphere are also investigated: in particular, it appears that bending of equipotentials may be reduced by cross-field flow during the merging of field lines and that open field lines connected to the polar caps emerge from a long and narrow slot extending along the tail.

Sources of magnetic fields in recurrent interplanetary streams

NASA Technical Reports Server (NTRS)

Burlaga, L. F.; Behannon, K. W.; Hansen, S. F.; Pneuman, G. W.; Feldman, W. C.

1977-01-01

The sources of magnetic fields in recurrent streams were examined. Most fields and plasmas at 1 AU were related to coronal holes, and the magnetic field lines were open in those holes. Some of the magnetic fields and plasmas were related to open field line regions on the sun which were not associated with known coronal holes, indicating that open field lines are more basic than coronal holes as sources of the solar wind. Magnetic field intensities in five equatorial coronal holes ranged from 2G to 18G. Average measured photospheric magnetic fields along the footprints of the corresponding unipolar fields on circular equatorial arcs at 2.5 solar radii had a similar range and average, but in two cases the intensities were approximately three times higher than the projected intensities. The coronal footprints of the sector boundaries on the source surface at 2.5 solar radii, meandered between -45 deg and +45 deg latitude, and their inclination ranged from near zero to near ninety degrees.

Field evaluation of effect of temperature on release of Disparlure from a pheromone-baited trapping system used to monitor gypsy moth (Lepidoptera: Lymantriidae)

Treesearch

Patrick C. Tobin; Aijun Zhang; Ksenia Onufrieva; Donna Leonard

2011-01-01

Traps baited with disparlure, the synthetic form of the gypsy moth, Lymantria dispar (L.) (Lepidoptera: Lymantriidae), sex pheromone are used to detect newly founded populations and estimate population density across the United States. The lures used in trapping devices are exposed to field conditions with varying climates, which can affect the rate...

Responding to the Challenges of KM Education in the LIS Sector: Some Academic and Professional Perspectives

ERIC Educational Resources Information Center

Hazeri, Afsaneh; Martin, Bill

2009-01-01

As a newly emerging field of study, KM education is faced with significant challenges which continue to evolve. Informed by wider organisational perspectives, this paper presents the findings of recent research into this field. The first part of the research was in the form of an online survey canvassing the views of the wider LIS community on the…

Control of the Tomato Leafminer, Tuta absoluta (Lepidoptera: Gelechiidae), in Open-Field Tomatoes by Indigenous Natural Enemies Occurring in Israel.

PubMed

Shaltiel-Harpaz, Liora; Gerling, Dan; Graph, Shaul; Kedoshim, Hendrika; Azolay, Lotem; Rozenberg, Tamir; Nachache, Yaakov; Steinberg, Shimon; Allouche, Arnon; Alon, Tamar

2016-02-01

The tomato leafminer, Tuta absoluta (Meyrick), had established in Israel by 2010, attacking both open-field tomatoes and greenhouse crops.We searched for its natural enemies in open-field tomatoes, and tried to determine their potential for controlling this pest. We surveyed the local natural enemies in open tomato fields and measured their impact on pest populations in an unsprayed field. We assessed the suppressive ability of the dominant hemipteran predator, Nesidiocoris tenuis Reuter, against T. absoluta under controlled laboratory conditions and evaluated the impact of its augmentation on T. absoluta control in open-field tomatoes. We found five natural enemy species:the predator, N. tenuis, two braconids, and two eulophids. Predation accounted for 64.5±9.2% (mean ± SE) of T. absoluta larval mortality, whereas parasitism accounted for 20.96±7.5%. Together, they eliminated the pest population at tomato harvest time. Under controlled conditions, predation by N. tenuis rose from 58 to 72% with increased density of T. absoluta, suggesting positive density dependence. The reduction of T. absoluta (83%) by N. tenuis was higher than that of Bemisia tabaci (32%), suggesting a preference of N. tenuis for T. absoluta. Augmentation of N.tenuis was as effective as conventional treatment insecticide treatment, and plant damage was low and did not seem to affect yield. Results indicate that reduced pesticide use enables indigenous natural enemies, particularly N.tenuis, to successfully control T. absoluta and prevent crop damage in open-field tomatoes.

Employment programs and professionals with a disability.

PubMed

Donelly, Michelle; Given, Fiona

2010-01-01

It is unclear whether or not open (competitive) employment programs are meeting the needs of the growing numbers of people with a disability seeking professional employment. To understand and describe the experience of a newly graduated professional (Michael) who was seeking open employment support and to analyze those experiences in relation to principles of effective open employment support. Michael a recently graduated accountant who also has a physical disability. A review of the literature was undertaken to identify recommended principles and practices for the conduct of effective open employment and career development programs. A case study was used to describe Michael's experiences as he sought professional employment. Michael's experiences were analysed in relation to recommended principles and practice. The analysis confirmed that the concerns Michael experienced about the supported employment program compromised the effectiveness of the support he received. Employment services based on models of independent living, disability service standards and remediation are likely to focus on the 'pathology' or performance 'deficits' of the person with a disability. Successful open employment models are more likely to place pre-eminence on the perspective of the person with a disability and effective practices for securing employment.

40 CFR 49.133 - Rule for agricultural burning permits.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... (v) A description of the burning method(s) to be used (pile or stack burn, open field or broadcast burn, windrow burn, mobile field sanitizer, etc.) and the amount of material to be burned with each... person must comply with § 49.131 General rule for open burning or the EPA-approved Tribal open burning...

The first Neanderthal remains from an open-air Middle Palaeolithic site in the Levant.

PubMed

Been, Ella; Hovers, Erella; Ekshtain, Ravid; Malinski-Buller, Ariel; Agha, Nuha; Barash, Alon; Mayer, Daniella E Bar-Yosef; Benazzi, Stefano; Hublin, Jean-Jacques; Levin, Lihi; Greenbaum, Noam; Mitki, Netta; Oxilia, Gregorio; Porat, Naomi; Roskin, Joel; Soudack, Michalle; Yeshurun, Reuven; Shahack-Gross, Ruth; Nir, Nadav; Stahlschmidt, Mareike C; Rak, Yoel; Barzilai, Omry

2017-06-07

The late Middle Palaeolithic (MP) settlement patterns in the Levant included the repeated use of caves and open landscape sites. The fossil record shows that two types of hominins occupied the region during this period-Neandertals and Homo sapiens. Until recently, diagnostic fossil remains were found only at cave sites. Because the two populations in this region left similar material cultural remains, it was impossible to attribute any open-air site to either species. In this study, we present newly discovered fossil remains from intact archaeological layers of the open-air site 'Ein Qashish, in northern Israel. The hominin remains represent three individuals: EQH1, a nondiagnostic skull fragment; EQH2, an upper right third molar (RM 3 ); and EQH3, lower limb bones of a young Neandertal male. EQH2 and EQH3 constitute the first diagnostic anatomical remains of Neandertals at an open-air site in the Levant. The optically stimulated luminescence ages suggest that Neandertals repeatedly visited 'Ein Qashish between 70 and 60 ka. The discovery of Neandertals at open-air sites during the late MP reinforces the view that Neandertals were a resilient population in the Levant shortly before Upper Palaeolithic Homo sapiens populated the region.

Comparison of repaglinide and metformin monotherapy as an initial therapy in Chinese patients with newly diagnosed type 2 diabetes mellitus.

PubMed

Fang, Fu-Sheng; Gong, Yan-Ping; Li, Chun-Lin; Li, Jian; Tian, Hui; Huang, Wei; Wang, Liang-Chen; Li, Lin

2014-06-01

We aimed to compare the effect of repaglinide and metformin monotherapy as an initial therapy in Chinese patients with newly diagnosed type 2 diabetes mellitus (T2DM). In this 15-week, open-labelled, parallel-controlled, randomised study, 60 Chinese drug-naive patients with newly diagnosed T2DM were randomised (2:1) to receive repaglinide or metformin monotherapy. Primary endpoint was change in HbA1c from baseline to the end of the trial. Secondary endpoints included changes in glycaemic variability, insulin sensitivity and β-cell function. Patients in both repaglinide and metformin groups achieved significant reductions in HbA1c (-1.8 ± 1.5 vs -1.6 ± 1.5%), FPG (fasting blood glucose) (-1.7 ± 1.7 vs -2.1 ± 1.7  mmol/l) and 2-h PPG (post-prandial glucose) (-3.8 ± 3.1 vs -3.8 ± 3.6  mmol/l), with no statistical differences between the groups. Glycaemic variability, glucose infusion rate and β-cell function were all significantly improved from baseline in the two groups (all P<0.05), without any statistical differences in the improvement between the groups. Repaglinide and metformin achieved comparable efficacy in improving glycaemic control, reducing glycaemic variability, enhancing insulin sensitivity and ameliorating β-cell function. Therefore, repaglinide is an optional agent for initial therapy in Chinese patients with newly diagnosed T2DM. © 2014 European Society of Endocrinology.

MS Ivins and Astronaut Shepherd at work in Destiny module

NASA Image and Video Library

2001-02-11

STS98-E-5143 (11 February 2001) --- Astronauts Marsha S. Ivins (from the left), STS-98 mission specialist, Kenneth D. Cockrell, STS-98 mission commander; and William M. Shepherd, Expedition One mission commander, discuss the organizational "game plan" onboard the newly opened Destiny laboratory on the International Space Station (ISS). After Shepherd opened the Destiny hatch, he and Cockrell ventured inside at 8:38 a.m. (CST), February 11, 2001. As depicted in subsequent digital images in this series, members of both crews went to work quickly inside the new module, activating air systems, fire extinguishers, alarm systems, computers and internal communications. The crew also took some photos and continued equipment transfers from the shuttle to the station.

STS-98 and Expedition One crew prepare to open U.S. Lab hatch

NASA Image and Video Library

2001-02-11

STS098-352-0025 (11 February 2001) --- STS-98 mission commander Kenneth D. Cockrell (left) assists as Expedition One commander William M. (Bill) Shepherd opens the hatch to the newly attached Destiny laboratory. The crews of Atlantis and the International Space Station entered the laboratory shortly after this photo was made on February 11; and the astronauts and cosmonauts spent the first full day of what are planned to be years of work ahead inside the orbiting science and command center. Members of both crews went to work quickly inside the new module, activating air systems, fire extinguishers, alarm systems, computers and internal communications. The crew also continued equipment transfers from the shuttle to the station.

Expedition 53-54 Crew Docks to the Space Station

NASA Image and Video Library

2017-09-13

After launching in their Soyuz MS-06 spacecraft from the Baikonur Cosmodrome in Kazakhstan, Expedition 53-54 Soyuz Commander Alexander Misurkin of Roscosmos and flight engineers Mark Vande Hei and Joe Acaba of NASA arrived at the International Space Station Sept. 13. Following their six-hour journey, they docked their Soyuz to the Poisk module on the Russian segment of the complex. Misurkin, Vande Hei and Acaba opened hatches and were greeted by station Commander Randy Bresnik of NASA and flight engineers Sergey Ryazanskiy of Roscosmos and Paolo Nespoli of the European Space Agency. As the hatches were opened, the families of the newly arrived crew members and American and Russian space officials viewed the activities from a conference facility in Baikonur.

Zirconium(IV)-Catalyzed Ring Opening of on-DNA Epoxides in Water.

PubMed

Fan, Lijun; Davie, Christopher P

2017-05-04

DNA-encoded library technology (ELT) has spurred wide interest in the pharmaceutical industry as a powerful tool for hit and lead generation. In recent years a number of "DNA-compatible" chemical modifications have been published and used to synthesize vastly diverse screening libraries. Herein we report a newly developed, zirconium tetrakis(dodecyl sulfate) [Zr(DS) 4 ] catalyzed ring-opening of on-DNA epoxides in water with amines, including anilines. Subsequent cyclization of the resulting on-DNA β-amino alcohols leads to a variety of biologically interesting, nonaromatic heterocycles. Under these conditions, a library of 137 million on-DNA β-amino alcohols and their cyclization products was assembled. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Depressed emission between magnetic arcades near a sunspot

NASA Astrophysics Data System (ADS)

Ryabov, B. I.; Shibasaki, K.

The locations of the depressed emission in microwaves, EUV and soft X-rays are compared with each other and with the location of the plasma outflow in the active region (AR) 8535 on the Sun. We found that two open-field regions overlap the regions of depressed emission near the AR's sunspot. These two open-field regions are simulated with the potential-field source-surface (PFSS) model under radial distances of RSS = 1.8 R⊙ and RSS = 2.5 R⊙. Each open-field region is located between the arcades of the loops of the same magnetic polarity. The former open-field region covers the region of the plasma outflow, which is thus useful for the tests on connection to the heliosphere. The utmost microwave depression of the intensity in the ordinary mode (the Very Large Array 15 GHz observations) also overlaps the region of the plasma outflow and thus indicates this outflow. The lasting for eight days depression in soft X-rays and the SOHO EIT 2.84× 10-8 m images are attributed to the evacuation of as hot coronal plasma as T≥ 2× 106 K from the extended in height (``open") magnetic structures. We conclude that the AR 8535 presents the sunspot atmosphere affected by the large-scale magnetic fields.

Simulation and Analysis of Electric Field for the Disconnector Switch Incomplete Opening Position Based on 220kV GIS

NASA Astrophysics Data System (ADS)

Wang, Feifeng; Huang, Huimin; Su, Yi; Yan, Dandan; Lu, Yufeng; Xia, Xiaofei; Yang, Jian

2018-05-01

It has accounted for a large proportion of GIS equipment defects, which cause the disconnector switches to incomplete open-close position. Once opening operation is not in place, it will arouse continuous arcing between contacts to reduce insulation strength. Otherwise, the intense heat give rise to burn the contact, which has a severe effect on the safe operation of power grid. This paper analyzes some typical defection cases about the opening operation incomplete for disconnector switches of GIS. The COMSOL Multiphysics is applied to verify the influence on electric field distribution. The results show that moving contact out shield is 20 mm, the electric field distribution of the moving contact surface is uneven, and the maximum electric field value can reach 9.74 kV/mm.

Open-field exposure facilitates consummatory extinction.

PubMed

Justel, Nadia; Psyrdellis, Mariana; Pautassi, Ricardo M

2016-12-07

During extinction, the organism learns that a conditioned stimulus or a conditioned response is no longer associated with an unconditioned stimulus, and as a consequence, a decrement in the response is presented. The exposure to novel situations (e.g. exploration of a novel open field) has been used widely to modulate (i.e. either enhance or deteriorate) learning and memory. The aim of the present study was to test whether open-field exposure could modulate consummatory extinction. The results indicated that open-field exposure accelerated the extinction response (i.e. experimental animals provided novelty exposure had lower consummatory behavior than control animals) when applied before - but not after - the first extinction trial, or when applied before the second extinction trial. The results suggest that environmental treatments such as novelty exposure provide a valuable, nonpharmacological alternative to potentially modulate extinction processes.

The Open Flux Problem

NASA Astrophysics Data System (ADS)

Linker, J. A.; Caplan, R. M.; Downs, C.; Riley, P.; Mikic, Z.; Lionello, R.; Henney, C. J.; Arge, C. N.; Liu, Y.; Derosa, M. L.; Yeates, A.; Owens, M. J.

2017-10-01

The heliospheric magnetic field is of pivotal importance in solar and space physics. The field is rooted in the Sun’s photosphere, where it has been observed for many years. Global maps of the solar magnetic field based on full-disk magnetograms are commonly used as boundary conditions for coronal and solar wind models. Two primary observational constraints on the models are (1) the open field regions in the model should approximately correspond to coronal holes (CHs) observed in emission and (2) the magnitude of the open magnetic flux in the model should match that inferred from in situ spacecraft measurements. In this study, we calculate both magnetohydrodynamic and potential field source surface solutions using 14 different magnetic maps produced from five different types of observatory magnetograms, for the time period surrounding 2010 July. We have found that for all of the model/map combinations, models that have CH areas close to observations underestimate the interplanetary magnetic flux, or, conversely, for models to match the interplanetary flux, the modeled open field regions are larger than CHs observed in EUV emission. In an alternative approach, we estimate the open magnetic flux entirely from solar observations by combining automatically detected CHs for Carrington rotation 2098 with observatory synoptic magnetic maps. This approach also underestimates the interplanetary magnetic flux. Our results imply that either typical observatory maps underestimate the Sun’s magnetic flux, or a significant portion of the open magnetic flux is not rooted in regions that are obviously dark in EUV and X-ray emission.

Effects of a single inhalative exposure to formaldehyde on the open field behavior of mice.

PubMed

Malek, Fathi A; Möritz, Klaus-Uwe; Fanghänel, Jochen

2004-02-01

The effects of formaldehyde on the explorative behavior and locomotor activity of mice after a single inhalative exposure were examined in an open field. Adult male mice were exposed to approximately 1.1 ppm, 2.3 ppm, or 5.2 ppm formaldehyde vapour for 2 hours and the open field test was carried out two hours after the end of exposure (trial 1) and repeated 24 hours thereafter (trial 2). The following behavioral parameters were quantitatively examined: numbers of crossed floor squares (inner, peripheral, total), sniffing, grooming, rearing, climbing, and incidence of fecal boli. The results of the first trial revealed that the motion activity was significantly reduced in all exposed groups. In the 1.1 ppm group, the frequency of rearing was reduced and that of floor sniffing increased. The exposure to the two higher formaldehyde concentrations caused a significant decrease in total numbers of floor squares crossed by the subjects, air sniffing, and rearing. The open field test on the next day (trial 2) showed that the frequencies of floor sniffing, grooming, and rearing in all formaldehyde groups were significantly altered. In the 2.5 ppm group, an increased incidence of fecal boli was observed. From the results obtained, we conclude that the exposure of male mice to formaldehyde vapour affects their locomotor and explorative activity in the open field, and that some open field parameters are still altered in the exposed animals even after 24 hours.

The Open Flux Problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Linker, J. A.; Caplan, R. M.; Downs, C.

The heliospheric magnetic field is of pivotal importance in solar and space physics. The field is rooted in the Sun’s photosphere, where it has been observed for many years. Global maps of the solar magnetic field based on full-disk magnetograms are commonly used as boundary conditions for coronal and solar wind models. Two primary observational constraints on the models are (1) the open field regions in the model should approximately correspond to coronal holes (CHs) observed in emission and (2) the magnitude of the open magnetic flux in the model should match that inferred from in situ spacecraft measurements. Inmore » this study, we calculate both magnetohydrodynamic and potential field source surface solutions using 14 different magnetic maps produced from five different types of observatory magnetograms, for the time period surrounding 2010 July. We have found that for all of the model/map combinations, models that have CH areas close to observations underestimate the interplanetary magnetic flux, or, conversely, for models to match the interplanetary flux, the modeled open field regions are larger than CHs observed in EUV emission. In an alternative approach, we estimate the open magnetic flux entirely from solar observations by combining automatically detected CHs for Carrington rotation 2098 with observatory synoptic magnetic maps. This approach also underestimates the interplanetary magnetic flux. Our results imply that either typical observatory maps underestimate the Sun’s magnetic flux, or a significant portion of the open magnetic flux is not rooted in regions that are obviously dark in EUV and X-ray emission.« less

Influence of salinity on the early development and biochemical dynamics of a marine fish, Inimicus japonicus

NASA Astrophysics Data System (ADS)

Gong, Xu; Huang, Xuxiong; Wen, Wen

2018-03-01

Fertilised eggs of the devil stringer ( Inimicus japonicus) were incubated at different salinity levels (21, 25, 29, 33, and 37), and then the hatching performances, morphological parameters, and biochemical composition (protein, lipid and carbohydrate) of the larvae were assayed to determine the influence of salinity on the early development of I. japonicus. The tested salinity levels did not affect the times of hatching or mouth opening for yolk-sac larvae. However, the salinity significantly influenced the hatching and survival rates of open-mouthed larvae, as well as the morphology of yolk-sac larvae. The data indicated that 30.5 to 37.3 and 24.4 to 29.8 were suitable salinity ranges for the survival of embryos and larvae of I. japonicus, respectively. Larvae incubated at a salinity level of 29 had the greatest full lengths, and decreasing yolk volume was positively correlated with the environmental salinity. With increasing salinity, the individual dry weights of newly hatched larvae or open-mouthed larvae decreased significantly. Newly hatched larvae incubated at a salinity level of 29 had the greatest metabolic substrate contents and gross energy levels, while the openmouthed larvae's greatest values occurred at a salinity level of 25. Larvae incubated in the salinity range of 33 to 37 had the lowest nutritional reserves and energy values. Thus, the I. japonicus yolk-sac larvae acclimated more readily to the lower salinity level than the embryos, and higher salinity levels negatively influenced larval growth and development. In conclusion, the environmental salinity level should be maintained at 29-33 during embryogenesis and at 25-29 during early larval development for this species. Our results can be used to provide optimum aquaculture conditions for the early larval development of I. japonicus.

Influence of salinity on the early development and biochemical dynamics of a marine fish, Inimicus japonicus

NASA Astrophysics Data System (ADS)

Gong, Xu; Huang, Xuxiong; Wen, Wen

2017-05-01

Fertilised eggs of the devil stringer (Inimicus japonicus) were incubated at different salinity levels (21, 25, 29, 33, and 37), and then the hatching performances, morphological parameters, and biochemical composition (protein, lipid and carbohydrate) of the larvae were assayed to determine the influence of salinity on the early development of I. japonicus. The tested salinity levels did not affect the times of hatching or mouth opening for yolk-sac larvae. However, the salinity significantly influenced the hatching and survival rates of open-mouthed larvae, as well as the morphology of yolk-sac larvae. The data indicated that 30.5 to 37.3 and 24.4 to 29.8 were suitable salinity ranges for the survival of embryos and larvae of I. japonicus, respectively. Larvae incubated at a salinity level of 29 had the greatest full lengths, and decreasing yolk volume was positively correlated with the environmental salinity. With increasing salinity, the individual dry weights of newly hatched larvae or open-mouthed larvae decreased significantly. Newly hatched larvae incubated at a salinity level of 29 had the greatest metabolic substrate contents and gross energy levels, while the openmouthed larvae's greatest values occurred at a salinity level of 25. Larvae incubated in the salinity range of 33 to 37 had the lowest nutritional reserves and energy values. Thus, the I. japonicus yolk-sac larvae acclimated more readily to the lower salinity level than the embryos, and higher salinity levels negatively influenced larval growth and development. In conclusion, the environmental salinity level should be maintained at 29-33 during embryogenesis and at 25-29 during early larval development for this species. Our results can be used to provide optimum aquaculture conditions for the early larval development of I. japonicus.

Robotic and open radical prostatectomy in the public health sector: cost comparison.

PubMed

Hall, Rohan Matthew; Linklater, Nicholas; Coughlin, Geoff

2014-06-01

During 2008, the Royal Brisbane and Women's Hospital became the first public hospital in Australia to have a da Vinci Surgical Robot purchased by government funding. The cost of performing robotic surgery in the public sector is a contentious issue. This study is a single centre, cost analysis comparing open radical prostatectomy (RRP) and robotic-assisted radical prostatectomy (RALP) based on the newly introduced pure case-mix funding model. A retrospective chart review was performed for the first 100 RALPs and the previous 100 RRPs. Estimates of tangible costing and funding were generated for each admission and readmission, using the Royal Brisbane Hospital Transition II database, based on pure case-mix funding. The average cost for admission for RRP was A$13 605, compared to A$17 582 for the RALP. The average funding received for a RRP was A$11 781 compared to A$5496 for a RALP based on the newly introduced case-mix model. The average length of stay for RRP was 4.4 days (2-14) and for RALP, 1.2 days (1-4). The total cost of readmissions for RRP patients was A$70 487, compared to that of the RALP patients, A$7160. These were funded at A$55 639 and A$7624, respectively. RALP has shown a significant advantage with respect to length of stay and readmission rate. Based on the case-mix funding model RALP is poorly funded compared to its open equivalent. Queensland Health needs to plan on how robotic surgery is implemented and assess whether this technology is truly affordable in the public sector. © 2013 The Authors. ANZ Journal of Surgery © 2013 Royal Australasian College of Surgeons.

The complex magnetic field configuration of the Martian magnetotail as observed by MAVEN

NASA Astrophysics Data System (ADS)

DiBraccio, Gina A.; Luhmann, Janet; Curry, Shannon; Espley, Jared R.; Gruesbeck, Jacob; Xu, Shaosui; Mitchell, David; Soobiah, Yasir; Connerney, John E. P.; Dong, Chuanfei; Harada, Yuki; Ruhunusiri, Suranga; Halekas, Jasper; Hara, Takuya; Ma, Yingjuan; Brain, David; Jakosky, Bruce

2017-10-01

The Martian magnetosphere forms as the solar wind directly interacts with the planet’s upper atmosphere. During this interaction, the Sun’s interplanetary magnetic field (IMF) drapes around the planet and local crustal magnetic fields, creating a magnetosphere configuration that has attributes of both an induced magnetosphere like that of Venus, and a complex, small-scale magnetosphere like the Moon. In addition to the closed crustal fields and draped IMF at Mars, open magnetic fields are created when magnetic reconnection occurs between the planetary fields and the IMF. These various field topologies present a complex magnetotail structure that we are now able to explore using a combination of MAVEN observations and magnetohydrodynamic (MHD) simulations. Preliminary MHD results have suggested that the Martian magnetotail includes a dual-lobe component, composed of open crustal fields, enveloped by an induced comet-like tail. These simulated open-field lobes are twisted by roughly 45°, either clockwise or counterclockwise, from the ecliptic plane. This rotation depends on the east-west component of the IMF. We utilize MAVEN Magnetometer and Solar Wind Ion Analyzer (SWIA) measurements collected over two Earth years to analyze the tail magnetic field configuration as a function of IMF direction. Cross-tail views of the average measured magnetic field components directed toward and away from the planet are compared for a variety of solar wind parameters. We find that, in agreement with simulation results, the east-west IMF component strongly affects the magnetotail structure, twisting its sunward-antisunward polarity patterns in response to changing IMF orientation. Through a data-model comparison we are able to infer that regions of open magnetic fields in the tail are likely reconnected crustal fields. Futhermore, these open fields in the tail may contribute to atmospheric escape to space. From this investigation we are able to confirm that the Martian magnetotail is a hybrid configuration between intrinsic and induced magnetospheres, shifting the paradigm of Mars’ magnetosphere as we have understood it thus far.

The behaviour of the paradise fish (Macropodus opercularis) in two different open-fields. A correlation study.

PubMed

Gerlai, R; Csányi, V

1987-01-01

The behaviour of the paradise fish in a traditional "closed" and in a new "transparent" open-field was investigated. The traditional way of measuring ambulation scores was extended by recording ethologically defined behaviour units. The correlations found between the scores measured in the "closed" field and those measured in the "transparent" field are discussed in this paper.

Opening the Landsat Archive

USGS Publications Warehouse

,

2008-01-01

The USGS Landsat archive holds an unequaled 36-year record of the Earth's surface that is invaluable to climate change studies, forest and resource management activities, and emergency response operations. An aggressive effort is taking place to provide all Landsat imagery [scenes currently held in the USGS Earth Resources Observation and Science (EROS) Center archive, as well as newly acquired scenes daily] free of charge to users with electronic access via the Web by the end of December 2008. The entire Landsat 7 Enhanced Thematic Mapper Plus (ETM+) archive acquired since 1999 and any newly acquired Landsat 7 ETM+ images that have less than 40 percent cloud cover are currently available for download. When this endeavor is complete all Landsat 1-5 data will also be available for download. This includes Landsat 1-5 Multispectral Scanner (MSS) scenes, as well as Landsat 4 and 5 Thematic Mapper (TM) scenes.

Decoding sORF translation - from small proteins to gene regulation.

PubMed

Cabrera-Quio, Luis Enrique; Herberg, Sarah; Pauli, Andrea

2016-11-01

Translation is best known as the fundamental mechanism by which the ribosome converts a sequence of nucleotides into a string of amino acids. Extensive research over many years has elucidated the key principles of translation, and the majority of translated regions were thought to be known. The recent discovery of wide-spread translation outside of annotated protein-coding open reading frames (ORFs) came therefore as a surprise, raising the intriguing possibility that these newly discovered translated regions might have unrecognized protein-coding or gene-regulatory functions. Here, we highlight recent findings that provide evidence that some of these newly discovered translated short ORFs (sORFs) encode functional, previously missed small proteins, while others have regulatory roles. Based on known examples we will also speculate about putative additional roles and the potentially much wider impact that these translated regions might have on cellular homeostasis and gene regulation.

OpenMP-accelerated SWAT simulation using Intel C and FORTRAN compilers: Development and benchmark

NASA Astrophysics Data System (ADS)

Ki, Seo Jin; Sugimura, Tak; Kim, Albert S.

2015-02-01

We developed a practical method to accelerate execution of Soil and Water Assessment Tool (SWAT) using open (free) computational resources. The SWAT source code (rev 622) was recompiled using a non-commercial Intel FORTRAN compiler in Ubuntu 12.04 LTS Linux platform, and newly named iOMP-SWAT in this study. GNU utilities of make, gprof, and diff were used to develop the iOMP-SWAT package, profile memory usage, and check identicalness of parallel and serial simulations. Among 302 SWAT subroutines, the slowest routines were identified using GNU gprof, and later modified using Open Multiple Processing (OpenMP) library in an 8-core shared memory system. In addition, a C wrapping function was used to rapidly set large arrays to zero by cross compiling with the original SWAT FORTRAN package. A universal speedup ratio of 2.3 was achieved using input data sets of a large number of hydrological response units. As we specifically focus on acceleration of a single SWAT run, the use of iOMP-SWAT for parameter calibrations will significantly improve the performance of SWAT optimization.

ISEE 1 charged particle observations indicative of open magnetospheric field lines near the subsolar region

NASA Technical Reports Server (NTRS)

Williams, D. J.; Frank, L. A.

1980-01-01

On November 20, 1977, at 0230-0300 UT, ISEE 1 encountered unusual charged particle distributions within the magnetosphere. The three-dimensional distribution observations for energetic (greater than 24 keV) ions and plasma show the development of field-aligned asymmetries in the energetic ion distributions simultaneously with a marked change in plasma flow. It is concluded that the most likely explanation for these observations is that ISEE 1 encountered open magnetospheric field lines at its position within the magnetosphere (1030 LT and 1200 plus or minus 300 km from the magnetopause). Field lines were open near the geomagnetic equator, and the geometry was spatially or temporally variable. Other features of the field line topology are presented.

A PRIMER ON THE EPIDEMIOLOGIC FIELD STUDY OF YOUNG CHILDREN

EPA Science Inventory

Concern about children's environmental health is increasing as newly characterized risks are indentified. Often little data is available to guide policy decisions. Research on children's ambient exposures to environmental contaminants is essential to understand the magnitude ...

ARC-2012-ACD12-0022-007

NASA Image and Video Library

2012-02-02

Kepler Program VIP's from left Natalie Batalha, Bill Borucki and Jon Jenkins in front of a NASA Ames Hyperwall display of newly discovered planet K-22B art at the NAS (NASA Advanced Supercomputing) Facility, Moffett Field, CA (for aviation week)

On open and closed field line regions in Tsyganenko's field model and their possible associations with horse collar auroras

NASA Technical Reports Server (NTRS)

Birn, J.; Hones, E. W., Jr.; Craven, J. D.; Frank, L. A.; Elphinstone, R. D.; Stern, D. P.

1991-01-01

The boundary between open and closed field lines is investigated in the empirical Tsyganenko (1987) magnetic field model. All field lines extending to distances beyond -70 R(E), the tailward velocity limit of the Tsyganenko model are defined as open, while all other field lines, which cross the equatorial plane earthward of -70 R(E) and are connected with the earth at both ends, are assumed closed. It is found that this boundary at the surface of the earth, identified as the polar cap boundary, can exhibit the arrowhead shape, pointed toward the sun, which is found in horse collar auroras. For increasing activity levels, the polar cap increases in area and becomes rounder, so that the arrowhead shape is less pronounced. The presence of a net B(y) component can also lead to considerable rounding of the open flux region. The arrowhead shape is found to be closely associated with the increase of B(z) from the midnight region to the flanks of the tail, consistent with a similar increase of the plasma sheet thickness.

Geodetic evidence for en echelon dike emplacement and concurrent slow slip during the June 2007 intrusion and eruption at Kīlauea volcano, Hawaii

USGS Publications Warehouse

Montgomery-Brown, E. K.; Sinnett, D.K.; Poland, M.; Segall, P.; Orr, T.; Zebker, H.; Miklius, Asta

2010-01-01

A series of complex events at Kīlauea Volcano, Hawaii, 17 June to 19 June 2007, began with an intrusion in the upper east rift zone (ERZ) and culminated with a small eruption (1500 m3). Surface deformation due to the intrusion was recorded in unprecedented detail by Global Positioning System (GPS) and tilt networks as well as interferometric synthetic aperture radar (InSAR) data acquired by the ENVISAT and ALOS satellites. A joint nonlinear inversion of GPS, tilt, and InSAR data yields a deflationary source beneath the summit caldera and an ENE-striking uniform-opening dislocation with ~2 m opening, a dip of ∼80° to the south, and extending from the surface to ~2 km depth. This simple model reasonably fits the overall pattern of deformation but significantly misfits data near the western end of an inferred dike-like source. Three more complex dike models are tested that allow for distributed opening including (1) a dike that follows the surface trace of the active rift zone, (2) a dike that follows the symmetry axis of InSAR deformation, and (3) two en echelon dike segments beneath mapped surface cracks and newly formed steaming areas. The en echelon dike model best fits near-field GPS and tilt data. Maximum opening of 2.4 m occurred on the eastern segment beneath the eruptive vent. Although this model represents the best fit to the ERZ data, it still fails to explain data from a coastal tiltmeter and GPS sites on Kīlauea's southwestern flank. The southwest flank GPS sites and the coastal tiltmeter exhibit deformation consistent with observations of previous slow slip events beneath Kīlauea's south flank, but inconsistent with observations of previous intrusions. Slow slip events at Kīlauea and elsewhere are thought to occur in a transition zone between locked and stably sliding zones of a fault. An inversion including slip on a basal decollement improves fit to these data and suggests a maximum of ~15 cm of seaward fault motion, comparable to previous slow-slip events.

The effects of gonadectomy and binge-like ethanol exposure during adolescence on open field behaviour in adult male rats.

PubMed

Yan, Wensheng; Kang, Jie; Zhang, Guoliang; Li, Shuangcheng; Kang, Yunxiao; Wang, Lei; Shi, Geming

2015-09-14

Binge drinking ethanol exposure during adolescence can lead to long-term neurobehavioural damage. It is not known whether the pubertal surge in testosterone that occurs during adolescence might impact the neurobehavioural effects of early ethanol exposure in adult animals. We examined this hypothesis by performing sham or gonadectomy surgeries on Sprague-Dawley rats around postnatal day (P) 23. From P28-65,the rats were administered 3.0g/kg ethanol using a binge-like model of exposure. Dependent measurements included tests of open field behaviour, blood ethanol concentrations, and testosterone levels. As adults, significant decreases in open field activity were observed in the GX rats. The open field behaviour of the GX rats was restored after testosterone administration. Binge-like ethanol exposure altered most of the parameters of the open field behaviour, suggestive of alcohol-induced anxiety, but rats treated with alcohol in combination with gonadectomy showed less motor behaviour and grooming behaviour and an increase in immobility, suggesting ethanol-induced depression. These results indicated that testosterone is required for ethanol-induced behavioural changes and that testicular hormones are potent stimulators of ethanol-induced behaviours. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Monitoring of piglets' open field activity and choice behaviour during the replay of maternal vocalization: a comparison between Observer and PID technique.

PubMed

Puppe, B; Schön, P C; Wendland, K

1999-07-01

The paper presents a new system for the automatic monitoring of open field activity and choice behaviour of medium-sized animals. Passive infrared motion detectors (PID) were linked on-line via a digital I/O interface to a personal computer provided with self-developed analysis software based on LabVIEW (PID technique). The set up was used for testing 18 one-week-old piglets (Sus scrofa) for their approach to their mother's nursing vocalization replayed through loudspeakers. The results were validated by comparison with a conventional Observer technique, a computer-aided direct observation. In most of the cases, no differences were seen between the Observer and PID technique regarding the percentage of stay in previously defined open field segments, the locomotor open field activity, and the choice behaviour. The results revealed that piglets are clearly attracted by their mother's nursing vocalization. The monitoring system presented in this study is thus suitable for detailed behavioural investigations of individual acoustic recognition. In general, the PID technique is a useful tool for research into the behaviour of individual animals in a restricted open field which does not rely on subjective analysis by a human observer.

Physical condition, sex, and age-class of eastern red-backed salamanders (Plethodon cinereus) in forested and open habitats of West Virginia, USA

Treesearch

Breanna L. Riedel; Kevin R. Russell; W. Mark Ford

2012-01-01

Nonforested habitats such as open fields and pastures have been considered unsuitable for desiccation-prone woodland salamanders such as the Eastern Red-backed Salamander (Plethodon cinereus). Recent research has suggested that Plethodon cinereus may not only disperse across but also reside within open habitats including fields,...

Covariant open bosonic string field theory on multiple D-branes in the proper-time gauge

NASA Astrophysics Data System (ADS)

Lee, Taejin

2017-12-01

We construct a covariant open bosonic string field theory on multiple D-branes, which reduces to a non-Abelian group Yang-Mills gauge theory in the zero-slope limit. Making use of the first quantized open bosonic string in the proper time gauge, we convert the string amplitudes given by the Polyakov path integrals on string world sheets into those of the second quantized theory. The world sheet diagrams generated by the constructed open string field theory are planar in contrast to those of the Witten's cubic string field theory. However, the constructed string field theory is yet equivalent to the Witten's cubic string field theory. Having obtained planar diagrams, we may adopt the light-cone string field theory technique to calculate the multi-string scattering amplitudes with an arbitrary number of external strings. We examine in detail the three-string vertex diagram and the effective four-string vertex diagrams generated perturbatively by the three-string vertex at tree level. In the zero-slope limit, the string scattering amplitudes are identified precisely as those of non-Abelian Yang-Mills gauge theory if the external states are chosen to be massless vector particles.

Characterization of stress-induced suppression of long-term potentiation in the hippocampal CA1 field of freely moving rats.

PubMed

Hirata, Riki; Togashi, Hiroko; Matsumoto, Machiko; Yamaguchi, Taku; Izumi, Takeshi; Yoshioka, Mitsuhiro

2008-08-21

Several lines of evidence have shown that exposure to stress impairs long-term potentiation (LTP) in the CA1 field of the hippocampus, but the detailed mechanisms for this effect remain to be clarified. The present study elucidated the synaptic mechanism of stress-induced LTP suppression in conscious, freely moving rats using electrophysiological approaches. Open field stress (i.e., novel environment stress) and elevated platform stress (i.e., uncontrollable stress) were employed. Basal synaptic transmission was significantly reduced during exposure to elevated platform stress but not during exposure to open field stress. LTP induction was blocked by elevated platform stress but not influenced by open field stress. Significant increases in serum corticosterone levels were observed in the elevated platform stress group compared with the open field stress group. Furthermore, LTP suppression induced by elevated platform stress was prevented by pretreatment with an anxiolytic drug diazepam (1 mg/kg, i.p.). These results suggest that stress-induced LTP suppression depends on the relative intensity of the stressor. The inhibitory synaptic response induced by an intense psychological stress, such as elevated platform stress, may be attributable to LTP impairment in the CA1 field of the hippocampus.

Strong dependence of a pioneer shrub on seed dispersal services provided by an endemic endangered lizard in a Mediterranean island ecosystem.

PubMed

Neghme, Constanza; Santamaría, Luís; Calviño-Cancela, María

2017-01-01

The accelerating rate of vertebrate extinctions and population declines threatens to disrupt important ecological interactions, altering key ecosystem processes such as animal seed dispersal. The study of highly specialized mutualistic interactions is crucial to predict the consequences of population declines and extinctions. Islands offer unique opportunities to study highly specialized interactions, as they often have naturally depauperated faunas and are experiencing high rates of human-driven extinctions. In this study, we assess the effect of seed dispersal on seedling recruitment of Ephedra fragilis (Ephedraceae) on a Mediterranean island ecosystem. We used field data and stochastic simulation modeling to estimate seed fate and recruitment patterns of this pioneer shrub typical of arid and semiarid areas, and to estimate the dependence of recruitment on the lizard Podarcis lilfordi (Lacertidae), its only known seed disperser. Ephedra fragilis recruitment highly depended on lizards: lizards produced 3.8 times more newly-emerged seedlings than non-dispersed seeds and no seedlings from undispersed seeds survived the study period. Seed dispersal by lizards was mostly to open sites, which was key for the increased success observed, while undispersed seeds, falling under mother plants, suffered higher predation and lower seedling emergence and survival. The ability of this pioneer shrub to get established in open ground is crucial for vegetation colonization and restoration, especially on degraded lands affected by desertification, where they act as nurse plants for other species. Lizards are key in this process, which has important consequences for community structure and ecosystem functioning.

Convection-Enhanced Transport into Open Cavities : Effect of Cavity Aspect Ratio.

PubMed

Horner, Marc; Metcalfe, Guy; Ottino, J M

2015-09-01

Recirculating fluid regions occur in the human body both naturally and pathologically. Diffusion is commonly considered the predominant mechanism for mass transport into a recirculating flow region. While this may be true for steady flows, one must also consider the possibility of convective fluid exchange when the outer (free stream) flow is transient. In the case of an open cavity, convective exchange occurs via the formation of lobes at the downstream attachment point of the separating streamline. Previous studies revealed the effect of forcing amplitude and frequency on material transport rates into a square cavity (Horner in J Fluid Mech 452:199-229, 2002). This paper summarizes the effect of cavity aspect ratio on exchange rates. The transport process is characterized using both computational fluid dynamics modeling and dye-advection experiments. Lagrangian analysis of the computed flow field reveals the existence of turnstile lobe transport for this class of flows. Experiments show that material exchange rates do not vary linearly as a function of the cavity aspect ratio (A = W/H). Rather, optima are predicted for A ≈ 2 and A ≈ 2.73, with a minimum occurring at A ≈ 2.5. The minimum occurs at the point where the cavity flow structure bifurcates from a single recirculating flow cell into two corner eddies. These results have significant implications for mass transport environments where the geometry of the flow domain evolves with time, such as coronary stents and growing aneurysms. Indeed, device designers may be able to take advantage of the turnstile-lobe transport mechanism to tailor deposition rates near newly implanted medical devices.

Strong dependence of a pioneer shrub on seed dispersal services provided by an endemic endangered lizard in a Mediterranean island ecosystem

PubMed Central

Santamaría, Luís; Calviño-Cancela, María

2017-01-01

The accelerating rate of vertebrate extinctions and population declines threatens to disrupt important ecological interactions, altering key ecosystem processes such as animal seed dispersal. The study of highly specialized mutualistic interactions is crucial to predict the consequences of population declines and extinctions. Islands offer unique opportunities to study highly specialized interactions, as they often have naturally depauperated faunas and are experiencing high rates of human-driven extinctions. In this study, we assess the effect of seed dispersal on seedling recruitment of Ephedra fragilis (Ephedraceae) on a Mediterranean island ecosystem. We used field data and stochastic simulation modeling to estimate seed fate and recruitment patterns of this pioneer shrub typical of arid and semiarid areas, and to estimate the dependence of recruitment on the lizard Podarcis lilfordi (Lacertidae), its only known seed disperser. Ephedra fragilis recruitment highly depended on lizards: lizards produced 3.8 times more newly-emerged seedlings than non-dispersed seeds and no seedlings from undispersed seeds survived the study period. Seed dispersal by lizards was mostly to open sites, which was key for the increased success observed, while undispersed seeds, falling under mother plants, suffered higher predation and lower seedling emergence and survival. The ability of this pioneer shrub to get established in open ground is crucial for vegetation colonization and restoration, especially on degraded lands affected by desertification, where they act as nurse plants for other species. Lizards are key in this process, which has important consequences for community structure and ecosystem functioning. PMID:28827820

Open-field test site

NASA Astrophysics Data System (ADS)

Gyoda, Koichi; Shinozuka, Takashi

1995-06-01

An open-field test site with measurement equipment, a turn table, antenna positioners, and measurement auxiliary equipment was remodelled at the CRL north-site. This paper introduces the configuration, specifications and characteristics of this new open-field test site. Measured 3-m and 10-m site attenuations are in good agreement with theoretical values, and this means that this site is suitable for using 3-m and 10-m method EMI/EMC measurements. The site is expected to be effective for antenna measurement, antenna calibration, and studies on EMI/EMC measurement methods.

[Magnetotherapy designed to affect cervical sympathetic ganglia for the treatment of patients with primary open-angle glaucoma].

PubMed

Veselova, E V; Kamenskikh, T G; Raĭgorodkiĭ, Iu M; Kolbenev, I O; Myshkina, E S

2010-01-01

The traveling magnetic field was used to treat primary open-angle glaucoma. The field was applied to the projection of cervical sympathetic ganglia of the patients. Hemodynamic parameters of posterior short ciliary arteries and central retinal artery were analysed along with visual evoked potentials, visual field limits, and visual acuity. It was shown that magnetotherapy with the use of an AMO-ATOS apparatus produces better clinical results in patients with stage I and II primary open-angle glaucoma compared with medicamentous therapy (intake of trental tablets).

Lithium ameliorates open-field and elevated plus maze behaviors, and brain phospho-glycogen synthase kinase 3-beta expression in fragile X syndrome model mice.

PubMed

Chen, Xi; Sun, Weiwen; Pan, Ying; Yang, Quan; Cao, Kaiyi; Zhang, Jin; Zhang, Yizhi; Chen, Mincong; Chen, Feidi; Huang, Yueling; Dai, Lijun; Chen, Shengqiang

2013-10-01

To investigate whether lithium modifies open-field and elevated plus maze behavior, and brain phospho-glycogen synthase kinase 3 (P-GSK3beta) expression in Fmr1 knockout mice. One hundred and eighty FVB mice, including knockout and wild type, with an age of 30 days were used. An open-field and elevated plus maze was utilized to test behavior, while western blot was used to measure the P-GSK3beta expression. Six groups were formed: control (saline), lithium chloride 30, 60, 90, 120, and 200 mg/kg. The experiments were carried out in the Institute of Neuroscience, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China between January and June 2012. Lithium significantly decreased total distance, crossing, central area time, and center entry in the open-field test (p<0.05), and significantly reduced open-arm tracking, open-arm entry, and open-arm time in the elevated plus maze (p<0.05) in knockout mice. In wild type mice, significant changes were observed in both behavior tests in some treatment groups. Lithium ameliorated P-GSK3beta expression in the hippocampus of all the treatment groups in knockout mice (p<0.05). However, lithium did not modify either GSK3beta expression in tissues of knockout mice, or P-GSK3beta or GSK3beta expression in tissues of wild type mice. Lithium ameliorated open-field and elevated plus maze behaviors of Fmr1 knockout mice. This effect may be related to its enhancement of P-GSK3beta expression. Our findings suggest that lithium might have a therapeutic effect in fragile X syndrome.

Emotionality in growing pigs: is the open field a valid test?

PubMed

Donald, Ramona D; Healy, Susan D; Lawrence, Alistair B; Rutherford, Kenneth M D

2011-10-24

The ability to assess emotionality is important within animal welfare research. Yet, for farm animals, few tests of emotionality have been well validated. Here we investigated the construct validity of behavioural measures of pig emotionality in an open-field test by manipulating the experiences of pigs in three ways. In Experiment One (pharmacological manipulation), pigs pre-treated with Azaperone, a drug used to reduce stress in commercial pigs, were more active, spent more time exploring and vocalised less than control pigs. In Experiment Two (social manipulation), pigs that experienced the open-field arena with a familiar companion were also more exploratory, spent less time behaviourally idle, and were less vocal than controls although to a lesser degree than in Experiment One. In Experiment Three (novelty manipulation), pigs experiencing the open field for a second time were less active, explored less and vocalised less than they had done in the first exposure to the arena. A principal component analysis was conducted on data from all three trials. The first two components could be interpreted as relating to the form (cautious to exploratory) and magnitude (low to high arousal) of the emotional response to open-field testing. Based on these dimensions, in Experiment One, Azaperone pigs appeared to be less fearful than saline-treated controls. However, in Experiment Two, exposure to the arena with a conspecific did not affect the first two dimensions but did affect a third behavioural dimension, relating to oro-nasal exploration of the arena floor. In Experiment Three, repeat exposure altered the form but not the magnitude of emotional response: pigs were less exploratory in the second test. In conclusion, behavioural measures taken from pigs in an open-field test are sensitive to manipulations of their prior experience in a manner that suggests they reflect underlying emotionality. Behavioural measures taken during open-field exposure can be useful for making assessments of both pig emotionality and of their welfare. Copyright © 2011 Elsevier Inc. All rights reserved.

The irrationality of continued fire suppression: A partial analysis of the costs and benefits of restoration-based fuel reduction treatments vs. no treatment

Treesearch

G. B. Snider; P. J. Daugherty

2008-01-01

(Please note, this is an abstract only) In 1905, the Bureau of Forestry became the U.S. Forest Service and was given responsibility for protecting newly designated forest reserves. A critical part of its charge was the prevention and control of fires. In 1908 Congress set up a unique system, like an open checkbook, that assured payment for fire suppression as needed....

"You Have to Knock at the Door for the Door Get Open": Alternative Literacy Narratives and the Development of Textual Agency in Writing by Newly Literate Adults

ERIC Educational Resources Information Center

Rosenberg, Lauren

2008-01-01

This article is part of a project that involves case studies of four adults who attend an informal literacy center. I examine people's motivations to write when their main purpose is not to gain a degree or other credentials. Here I focus on one study member and how she uses writing to gain textual agency. By composing narratives that investigate…

Large-Scale Conformational Changes of Trypanosoma cruzi Proline Racemase Predicted by Accelerated Molecular Dynamics Simulation

PubMed Central

McCammon, J. Andrew

2011-01-01

Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is a life-threatening illness affecting 11–18 million people. Currently available treatments are limited, with unacceptable efficacy and safety profiles. Recent studies have revealed an essential T. cruzi proline racemase enzyme (TcPR) as an attractive candidate for improved chemotherapeutic intervention. Conformational changes associated with substrate binding to TcPR are believed to expose critical residues that elicit a host mitogenic B-cell response, a process contributing to parasite persistence and immune system evasion. Characterization of the conformational states of TcPR requires access to long-time-scale motions that are currently inaccessible by standard molecular dynamics simulations. Here we describe advanced accelerated molecular dynamics that extend the effective simulation time and capture large-scale motions of functional relevance. Conservation and fragment mapping analyses identified potential conformational epitopes located in the vicinity of newly identified transient binding pockets. The newly identified open TcPR conformations revealed by this study along with knowledge of the closed to open interconversion mechanism advances our understanding of TcPR function. The results and the strategy adopted in this work constitute an important step toward the rationalization of the molecular basis behind the mitogenic B-cell response of TcPR and provide new insights for future structure-based drug discovery. PMID:22022240

Large-scale conformational changes of Trypanosoma cruzi proline racemase predicted by accelerated molecular dynamics simulation.

PubMed

de Oliveira, César Augusto F; Grant, Barry J; Zhou, Michelle; McCammon, J Andrew

2011-10-01

Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is a life-threatening illness affecting 11-18 million people. Currently available treatments are limited, with unacceptable efficacy and safety profiles. Recent studies have revealed an essential T. cruzi proline racemase enzyme (TcPR) as an attractive candidate for improved chemotherapeutic intervention. Conformational changes associated with substrate binding to TcPR are believed to expose critical residues that elicit a host mitogenic B-cell response, a process contributing to parasite persistence and immune system evasion. Characterization of the conformational states of TcPR requires access to long-time-scale motions that are currently inaccessible by standard molecular dynamics simulations. Here we describe advanced accelerated molecular dynamics that extend the effective simulation time and capture large-scale motions of functional relevance. Conservation and fragment mapping analyses identified potential conformational epitopes located in the vicinity of newly identified transient binding pockets. The newly identified open TcPR conformations revealed by this study along with knowledge of the closed to open interconversion mechanism advances our understanding of TcPR function. The results and the strategy adopted in this work constitute an important step toward the rationalization of the molecular basis behind the mitogenic B-cell response of TcPR and provide new insights for future structure-based drug discovery.

Graphene: A Comprehensive Review.

PubMed

Ghuge, Aditya D; Shirode, Abhay R; Kadam, Vilasrao J

2017-01-01

Graphene, a one-atom thick, two-dimensional sheets of sp2hybridized carbon atoms packed in a hexagonal lattice with a Caron-Carbon distance of about 0.142 nm. Its extended honeycomb network forms the basic building block of other important allotropes; it can be stacked to form 3-Dgraphite, rolled to form 1-D-nanotubes and wrapped to form 0-D-fullerenes. Long-range π conjugation in graphene results in its extraordinary thermal, mechanical and electrical properties, which have been the interest of many theoretical studies and recently became an exciting area for scientists. Graphene is impermeable to gas and liquids, has excellent thermal conductivity and higher current density in comparison to other most effective materials. All of its exceptional properties have opened up new avenues for the use of graphene in nano-devices and nano-systems, which initiated its prominent use as a material for drug targeting. In addition, several fabrication techniques are outlined, starting from the mechanical exfoliation of high-quality graphene to the direct growth on silicon carbide or metal substrates and from the chemical routes utilizing graphene oxide to the newly developed approach at the molecular level. By this article reviewers intend to emphasize on unique properties, fabrication techniques and updated applications of graphene. In addition, we discuss about the potential of graphene in drug targeting in fields of nanotechnology, biomedical engineering and technology and its use for innovations in various fields such as electronics and photonics. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

The Spin Evolution of Fast-rotating, Magnetized Super-Chandrasekhar White Dwarfs in the Aftermath of White Dwarf Mergers

NASA Astrophysics Data System (ADS)

Becerra, L.; Rueda, J. A.; Lorén-Aguilar, P.; García-Berro, E.

2018-04-01

The evolution of the remnant of the merger of two white dwarfs is still an open problem. Furthermore, few studies have addressed the case in which the remnant is a magnetic white dwarf with a mass larger than the Chandrasekhar limiting mass. Angular momentum losses might bring the remnant of the merger to the physical conditions suitable for developing a thermonuclear explosion. Alternatively, the remnant may be prone to gravitational or rotational instabilities, depending on the initial conditions reached after the coalescence. Dipole magnetic braking is one of the mechanisms that can drive such losses of angular momentum. However, the timescale on which these losses occur depends on several parameters, like the strength of the magnetic field. In addition, the coalescence leaves a surrounding Keplerian disk that can be accreted by the newly formed white dwarf. Here we compute the post-merger evolution of a super-Chandrasekhar magnetized white dwarf taking into account all the relevant physical processes. These include magnetic torques acting on the star, accretion from the Keplerian disk, the threading of the magnetic field lines through the disk, and the thermal evolution of the white dwarf core. We find that the central remnant can reach the conditions suitable to develop a thermonuclear explosion before other instabilities (such as the inverse beta-decay instability or the secular axisymmetric instability) are reached, which would instead lead to gravitational collapse of the magnetized remnant.

Radio Emissions from Electrical Activity in Martian Dust Storms

NASA Astrophysics Data System (ADS)

Majid, W.; Arabshahi, S.; Kocz, J.; Schulter, T.; White, L.

2017-12-01

Dust storms on Mars are predicted to be capable of producing electrostatic fields and discharges, even larger than those in dust storms on Earth. There are three key elements in the characterization of Martian electrostatic discharges: dependence on Martian environmental conditions, event rate, and the strength of the generated electric fields. The detection and characterization of electric activity in Martian dust storms has important implications for habitability, and preparations for human exploration of the red planet. Furthermore, electrostatic discharges may be linked to local chemistry and plays an important role in the predicted global electrical circuit. Because of the continuous Mars telecommunication needs of NASA's Mars-based assets, the Deep Space Network (DSN) is the only facility in the world that combines long term, high cadence, observing opportunities with large sensitive telescopes, making it a unique asset worldwide in searching for and characterizing electrostatic activity from large scale convective dust storms at Mars. We will describe a newly inaugurated program at NASA's Madrid Deep Space Communication Complex to carry out a long-term monitoring campaign to search for and characterize the entire Mars hemisphere for powerful discharges during routine tracking of spacecraft at Mars on an entirely non-interfering basis. The ground-based detections will also have important implications for the design of a future instrument that could make similar in-situ measurements from orbit or from the surface of Mars, with far greater sensitivity and duty cycle, opening up a new window in our understanding of the Martian environment.

Development and characterization of semiconductor ion detectors for plasma diagnostics in the range over 0.3 keV

NASA Astrophysics Data System (ADS)

Cho, T.; Sakamoto, Y.; Hirata, M.; Kohagura, J.; Makino, K.; Kanke, S.; Takahashi, K.; Okamura, T.; Nakashima, Y.; Yatsu, K.; Tamano, T.; Miyoshi, S.

1997-01-01

For the purpose of plasma-ion-energy analyses in a wide-energy range from a few hundred eV to hundreds of keV, upgraded semiconductor detectors are newly fabricated and characterized using a test-ion-beam line from 0.3 to 12 keV. In particular, the detectable lowest-ion energy is drastically improved at least down to 0.3 keV; this energy is one to two orders-of-magnitude better than those for commercially available Si-surface-barrier diodes employed for previous plasma-ion diagnostics. A signal-to-noise ratio of two to three orders-of-magnitude better than that for usual metal-collector detectors is demonstrated for the compact-sized semiconductor along with the availability of the use under conditions of a good vacuum and a strong-magnetic field. Such characteristics are achieved due to the improving methods of the optimization of the thicknesses of a Si dead layer and a SiO2 layer, as well as the nitrogen-doping technique near the depletion layer along with minimizing impurity concentrations in Si. Such an upgraded capability of an extremely low-energy-ion detection with the low-noise characteristics enlarges research regimes of plasma-ion behavior using semiconductor detectors not only in the divertor regions of tokamaks but in wider spectra of open-field plasma devices including tandem mirrors. An application of the semiconductor ion detector for plasma-ion diagnostics is demonstrated in a specially designed ion-spectrometer structure.

Quantifying the effect of hydrogen on dislocation dynamics: A three-dimensional discrete dislocation dynamics framework

NASA Astrophysics Data System (ADS)

Gu, Yejun; El-Awady, Jaafar A.

2018-03-01

We present a new framework to quantify the effect of hydrogen on dislocations using large scale three-dimensional (3D) discrete dislocation dynamics (DDD) simulations. In this model, the first order elastic interaction energy associated with the hydrogen-induced volume change is accounted for. The three-dimensional stress tensor induced by hydrogen concentration, which is in equilibrium with respect to the dislocation stress field, is derived using the Eshelby inclusion model, while the hydrogen bulk diffusion is treated as a continuum process. This newly developed framework is utilized to quantify the effect of different hydrogen concentrations on the dynamics of a glide dislocation in the absence of an applied stress field as well as on the spacing between dislocations in an array of parallel edge dislocations. A shielding effect is observed for materials having a large hydrogen diffusion coefficient, with the shield effect leading to the homogenization of the shrinkage process leading to the glide loop maintaining its circular shape, as well as resulting in a decrease in dislocation separation distances in the array of parallel edge dislocations. On the other hand, for materials having a small hydrogen diffusion coefficient, the high hydrogen concentrations around the edge characters of the dislocations act to pin them. Higher stresses are required to be able to unpin the dislocations from the hydrogen clouds surrounding them. Finally, this new framework can open the door for further large scale studies on the effect of hydrogen on the different aspects of dislocation-mediated plasticity in metals. With minor modifications of the current formulations, the framework can also be extended to account for general inclusion-induced stress field in discrete dislocation dynamics simulations.

Dayside and nightside magnetic field responses at 780 km altitude to dayside reconnection.

NASA Astrophysics Data System (ADS)

Snekvik, Kristian; Østgaard, Nikolai; Tenfjord, Paul; Petter Reistad, Jone; Magnus Laundal, Karl; Milan, Stephen E.; Haaland, Stein E.

2017-04-01

During southward IMF, dayside reconnection will drive the Dungey cycle in the Earth's magnetosphere, which is manifested as a two cell convection pattern in the ionosphere. We address the response of the ionospheric convection to changes in the dayside reconnection rate. Previous studies have reported two apparently contradicting results. The first is that the ionospheric convection responds within one minute both near noon and near midnight. The second is that the response is 10-20 minutes delayed near midnight compared to near noon. To test these apparently contradicting scenarios, we have performed a statistical investigation of the response by examining the magnetic field perturbations at 780 km altitude due to dayside reconnection. The AMPERE data products derived from the Iridium constellation provide global maps of the disturbance magnetic field. The time development of the convection is modelled as the sum of an accelerating force and a decelerating force. Furthermore, the accelerating force is parametrised as a linear sum of past reconnection rates, while the decelerating force is proportional to the convection itself. This results in an asymptotic model which gradually reaches a steady-state value. By fitting the data to the model, we confirm previous reports of an almost immediate response both near noon and near midnight combined with a 10-20 minutes reconfiguration time of the two cell convection pattern. The e-folding time of the asymptotic model was found to be about 40 minutes. We present a new explanation of the response and reconfiguration times based on how MHD waves propagate in the magnetospheric lobes when newly reconnected open flux tubes are added to the lobes, and the magnetopause flaring angle increases.

Beta Testing of CFD Code for the Analysis of Combustion Systems

NASA Technical Reports Server (NTRS)

Yee, Emma; Wey, Thomas

2015-01-01

A preliminary version of OpenNCC was tested to assess its accuracy in generating steady-state temperature fields for combustion systems at atmospheric conditions using three-dimensional tetrahedral meshes. Meshes were generated from a CAD model of a single-element lean-direct injection combustor, and the latest version of OpenNCC was used to calculate combustor temperature fields. OpenNCC was shown to be capable of generating sustainable reacting flames using a tetrahedral mesh, and the subsequent results were compared to experimental results. While nonreacting flow results closely matched experimental results, a significant discrepancy was present between the code's reacting flow results and experimental results. When wide air circulation regions with high velocities were present in the model, this appeared to create inaccurately high temperature fields. Conversely, low recirculation velocities caused low temperature profiles. These observations will aid in future modification of OpenNCC reacting flow input parameters to improve the accuracy of calculated temperature fields.

Can the exposure of Apis mellifera (Hymenoptera, Apiadae) larvae to a field concentration of thiamethoxam affect newly emerged bees?

PubMed

Friol, Priscila Sepúlveda; Catae, Aline Fernanda; Tavares, Daiana Antonia; Malaspina, Osmar; Roat, Thaisa Cristina

2017-10-01

The use of insecticides on crops can affect non-target insects, such as bees. In addition to the adult bees, larvae can be exposed to the insecticide through contaminated floral resources. Therefore, this study aimed to investigate the possible effects of the exposure of A. mellifera larvae to a field concentration of thiamethoxam (0.001 ng/μL thiamethoxam) on larval and pupal survival and on the percentage of adult emergence. Additionally, its cytotoxic effects on the digestive cells of midgut, Malpighian tubules cells and Kenyon cells of the brain of newly emerged A. mellifera bees were analyzed. The results showed that larval exposure to this concentration of thiamethoxam did not influence larval and pupal survival or the percentage of adult bee emergence. However, this exposure caused ultra-structural alterations in the target and non-target organs of newly emerged bees. The digestive cell of bees that were exposed to the insecticide exhibited a basal labyrinth without long and thin channels and compromised mitochondria. In Malpighian tubules cells, disorganized basal labyrinth, dilated mitochondria with a deformed shape and a loss of cristae, and disorganized microvilli were observed. The results showed that the exposed bees presented Kenyon cells with alterations in the nucleus and mitochondria. These alterations indicate possible tissue degeneration, demonstrating the cytotoxicity of thiamethoxam in the target and non-target organs of newly emerged bees. Such results suggest cellular organelle impairment that can compromise cellular function of the midgut cells, Malpighian tubules cells and Kenyon cells, and, consequently, can compromise the longevity of the bees of the whole colony. Copyright © 2017 Elsevier Ltd. All rights reserved.

Safety evaluation of large external fixation clamps and frames in a magnetic resonance environment.

PubMed

Luechinger, Roger; Boesiger, Peter; Disegi, John A

2007-07-01

Large orthopedic external fixation clamps and related components were evaluated for force, torque, and heating response when subjected to the strong electromagnetic fields of magnetic-resonance (MR) imaging devices. Forces induced by a 3-Tesla (T) MR scanner were compiled for newly designed nonmagnetic clamps and older clamps that contained ferromagnetic components. Heating trials were performed in a 1.5 and in a 3 T MR scanner with two assembled external fixation frames. Forces of the newly designed clamps were more than a factor 2 lower as the gravitational force on the device whereas, magnetic forces on the older devices showed over 10 times the force induced by earth acceleration of gravity. No torque effects could be found for the newly designed clamps. Temperature measurements at the tips of Schanz screws in the 1.5 T MR scanner showed a rise of 0.7 degrees C for a pelvic frame and of 2.1 degrees C for a diamond knee bridge frame when normalized to a specific absorption rate (SAR) of 2 W/kg. The normalized temperature increases in the 3 T MR scanner were 0.9 degrees C for the pelvic frame and 1.1 degrees C for the knee bridge frame. Large external fixation frames assembled with the newly designed clamps (390 Series Clamps), carbon fiber reinforced rods, and implant quality 316L stainless steel Schanz screws met prevailing force and torque limits when tested in a 3-T field, and demonstrated temperature increase that met IEC-60601 guidelines for extremities. The influence of frame-induced eddy currents on the risk of peripheral nerve stimulation was not investigated. Copyright 2006 Wiley Periodicals, Inc.

Evolution of space open electric arc burning in the external axial magnetic field

NASA Astrophysics Data System (ADS)

Urusova, I. R.; Urusova, T. E.

2018-06-01

The calculation was made for open DC electric arc burning in an external uniform axial magnetic field. It was performed within the framework of a nonstationary three-dimensional mathematical model in approximation of partial local thermodynamic equilibrium of plasma. A "schematic" analog of electron temperature fluctuations was proposed for numerical realization of the open electric arc column of a helical shape. According to calculations, it was established that the column of the open electric arc takes a helical space shape. Plasma rotates around a longitudinal axis of the arc, at that the directions of plasma rotation near the cathode and the anode are opposite. In the arc cross-sections, the velocity of plasma rotation is unequal and the deviation value of the same part of the arc from the central axis varies in time. A helical shape of the open arc is not stable and varies in time. Apparently, the open arc cannot remain stable and invariable in the time helical shape in the external axial magnetic field.

Massive open star clusters using the VVV survey. II. Discovery of six clusters with Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Chené, A.-N.; Borissova, J.; Bonatto, C.; Majaess, D. J.; Baume, G.; Clarke, J. R. A.; Kurtev, R.; Schnurr, O.; Bouret, J.-C.; Catelan, M.; Emerson, J. P.; Feinstein, C.; Geisler, D.; de Grijs, R.; Hervé, A.; Ivanov, V. D.; Kumar, M. S. N.; Lucas, P.; Mahy, L.; Martins, F.; Mauro, F.; Minniti, D.; Moni Bidin, C.

2013-01-01

Context. The ESO Public Survey "VISTA Variables in the Vía Láctea" (VVV) provides deep multi-epoch infrared observations for an unprecedented 562 sq. degrees of the Galactic bulge, and adjacent regions of the disk. Nearly 150 new open clusters and cluster candidates have been discovered in this survey. Aims: This is the second in a series of papers about young, massive open clusters observed using the VVV survey. We present the first study of six recently discovered clusters. These clusters contain at least one newly discovered Wolf-Rayet (WR) star. Methods: Following the methodology presented in the first paper of the series, wide-field, deep JHKs VVV observations, combined with new infrared spectroscopy, are employed to constrain fundamental parameters for a subset of clusters. Results: We find that the six studied stellar groups are real young (2-7 Myr) and massive (between 0.8 and 2.2 × 103 M⊙) clusters. They are highly obscured (AV ~ 5-24 mag) and compact (1-2 pc). In addition to WR stars, two of the six clusters also contain at least one red supergiant star, and one of these two clusters also contains a blue supergiant. We claim the discovery of 8 new WR stars, and 3 stars showing WR-like emission lines which could be classified WR or OIf. Preliminary analysis provides initial masses of ~30-50 M⊙ for the WR stars. Finally, we discuss the spiral structure of the Galaxy using the six new clusters as tracers, together with the previously studied VVV clusters. Based on observations with ISAAC, VLT, ESO (programme 087.D-0341A), New Technology Telescope at ESO's La Silla Observatory (programme 087.D-0490A) and with the Clay telescope at the Las Campanas Observatory (programme CN2011A-086). Also based on data from the VVV survey (programme 172.B-2002).

Microwave corrosion detection using open ended rectangular waveguide sensors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qaddoumi, N.; Handjojo, L.; Bigelow, T.

The use of microwave and millimeter wave nondestructive testing methods utilizing open ended rectangular waveguide sensors has shown great potential for detecting minute thickness variations in laminate structures, in particular those backed by a conducting plate. Slight variations in the dielectric properties of materials may also be detected using a set of optimal parameters which include the standoff distance and the frequency of operation. In a recent investigation, on detecting rust under paint, the dielectric properties of rust were assumed to be similar to those of Fe{sub 2}O{sub 3} powder. These values were used in an electromagnetic model that simulatesmore » the interaction of fields radiated by a rectangular waveguide aperture with layered structures to obtain optimal parameters. The dielectric properties of Fe{sub 2}O{sub 3} were measured to be very similar to the properties of paint. Nevertheless, the presence of a simulated Fe{sub 2}O{sub 3} layer under a paint layer was detected. In this paper the dielectric properties of several different rust samples from different environments are measured. The measurements indicate that the nature of real rust is quite diverse and is different from Fe{sub 2}O{sub 3} and paint, indicating that the presence of rust under paint can be easily detected. The same electromagnetic model is also used (with the newly measured dielectric properties of real rust) to obtain an optimal standoff distance at a frequency of 24 GHz. The results indicate that variations in the magnitude as well as the phase of the reflection coefficient can be used to obtain information about the presence of rust. An experimental investigation on detecting the presence of very thin rust layers (2.5--5 x 10{sup {minus}2} mm [09--2.0 x 10{sup {minus}3} in.]) using an open ended rectangular waveguide probe is also conducted. Microwave images of rusted specimens, obtained at 24 GHz, are also presented.« less

32 CFR 158.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... routinely are put in place to provide support to many newly fielded weapons systems, including aircraft, land combat vehicles, and automated command and control systems. Systems support contracting authority... generally has less control over systems support contracts than other types of contracts. Theater business...

32 CFR 158.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... routinely are put in place to provide support to many newly fielded weapons systems, including aircraft, land combat vehicles, and automated command and control systems. Systems support contracting authority... generally has less control over systems support contracts than other types of contracts. Theater business...

32 CFR 158.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... routinely are put in place to provide support to many newly fielded weapons systems, including aircraft, land combat vehicles, and automated command and control systems. Systems support contracting authority... generally has less control over systems support contracts than other types of contracts. Theater business...

SCAT Classifications of 5 Supernovae with the UH88/SNIFS

NASA Astrophysics Data System (ADS)

Tucker, Michael A.; Huber, Mark; Shappee, Benjamin J.; Dong, Subo; Bose, S.; Chen, Ping

2018-03-01

We present the first classifications from the newly formed Spectral Classification of Astronomical Transients (SCAT) survey. SCAT is a transient identification survey utilizing the SuperNova Integral Field Spectrograph (SNIFS) on the University of Hawaii (UH) 88-inch telescope.

Effective post-construction best management practices (BMPs) to infiltrate and retain stormwater runoff.

DOT National Transportation Integrated Search

2017-06-01

Performance analyses of newly constructed linear BMPs in retaining stormwater run-off from 1 in. precipitation in : post-construction highway applications and urban areas were conducted using numerical simulations and field : observation. A series of...

Herbicide options for suppressing bermudagrass in sugarcane

USDA-ARS?s Scientific Manuscript database

Bermudagrass is a problematic weed in Louisiana sugarcane. The most effective herbicide options are limited to the fallow period prior to planting. Frequently, efforts to eliminate bermudagrass from fields during the fallow season are unsuccessful. This subjects newly planted sugarcane to competitio...

Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial.

PubMed

Yang, Wenying; Liu, Jie; Shan, Zhongyan; Tian, Haoming; Zhou, Zhiguang; Ji, Qiuhe; Weng, Jianping; Jia, Weiping; Lu, Juming; Liu, Jing; Xu, Yuan; Yang, Zhaojun; Chen, Wei

2014-01-01

Metformin is the only first-line oral hypoglycaemic drug for type 2 diabetes recommended by international guidelines with proven efficacy, safety, and cost-effectiveness. However, little information exists about its use in Asian populations. We aimed to ascertain the effectiveness of the α-glucosidase inhibitor acarbose, extensively adopted in China, compared with metformin as the alternative initial therapy for newly diagnosed type 2 diabetes. In this 48-week, randomised, open-label, non-inferiority trial, patients who were newly diagnosed with type 2 diabetes, with a mean HbA1c of 7·5%, were enrolled from 11 sites in China. After a 4-week lifestyle modification run-in, patients were assigned to 24 weeks of monotherapy with metformin or acarbose as the initial treatment, followed by a 24-week therapy phase during which add-on therapy was used if prespecified glucose targets were not achieved. Primary endpoints were to establish whether acarbose was non-inferior to metformin in HbA1c reduction at week 24 and week 48 timepoints. The non-inferiority margin was 0·3%, with an expected null difference in the change from baseline to week 48 in HbA1c. Analysis was done on a modified intention-to-treat population. This study was registered with Chinese Clinical Trial Registry, number ChiCTR-TRC-08000231. Of the 788 patients randomly assigned to treatment groups, 784 patients started the intended study drug. HbA1c reduction at week 24 was -1·17% in the acarbose group and -1·19% in the metformin group. At week 48, the HbA1c reduction was -1·11% (acarbose) and -1·12% (metformin) with difference 0·01% (95% CI -0·12 to 0·14, p=0·8999). Six (2%) patients in the acarbose group and seven (2%) patients in the metformin group had serious adverse events, and two (1%) and four (1%) had hypoglycaemic episodes. This study provides evidence that acarbose is similar to metformin in efficacy, and is therefore a viable choice for initial therapy in Chinese patients newly diagnosed with type 2 diabetes. Bayer Healthcare (China) and Double Crane Phama. Copyright © 2014 Elsevier Ltd. All rights reserved.

Rapid Clinical Bacteriology and Its Future Impact

PubMed Central

Durand, Géraldine; Peyret, Michel; Chatellier, Sonia; Zambardi, Gilles; Schrenzel, Jacques; Shortridge, Dee; Engelhardt, Anette; Dunne, William Michael

2013-01-01

Clinical microbiology has always been a slowly evolving and conservative science. The sub-field of bacteriology has been and still is dominated for over a century by culture-based technologies. The integration of serological and molecular methodologies during the seventies and eighties of the previous century took place relatively slowly and in a cumbersome fashion. When nucleic acid amplification technologies became available in the early nineties, the predicted "revolution" was again slow but in the end a real paradigm shift did take place. Several of the culture-based technologies were successfully replaced by tests aimed at nucleic acid detection. More recently a second revolution occurred. Mass spectrometry was introduced and broadly accepted as a new diagnostic gold standard for microbial species identification. Apparently, the diagnostic landscape is changing, albeit slowly, and the combination of newly identified infectious etiologies and the availability of innovative technologies has now opened new avenues for modernizing clinical microbiology. However, the improvement of microbial antibiotic susceptibility testing is still lagging behind. In this review we aim to sketch the most recent developments in laboratory-based clinical bacteriology and to provide an overview of emerging novel diagnostic approaches. PMID:23301218

Emerging drugs which target the renin-angiotensin-aldosterone system.

PubMed

Steckelings, Ulrike Muscha; Paulis, Ludovit; Unger, Thomas; Bader, Michael

2011-12-01

The renin-angiotensin-aldosterone system (RAAS) is already the most important target for drugs in the cardiovascular system. However, still new developments are underway to interfere with the system on different levels. The novel strategies to interfere with RAAS aim to reduce the synthesis of the two major RAAS effector hormones, angiotensin (Ang) II and aldosterone, or interfere with their receptors, AT1 and mineralocorticoid receptor, respectively. Moreover, novel targets have been identified in RAAS, such as the (pro)renin receptor, and molecules, which counteract the classical actions of Ang II and are therefore beneficial in cardiovascular diseases. These include the AT2 receptor and the ACE2/Ang-(1-7)/Mas axis. The search for drugs activating these tissue-protective arms of RAAS is therefore the most innovative field in RAAS pharmacology. Most of the novel pharmacological strategies to inhibit the classical RAAS need to prove their superiority above the existing treatment in clinical trials and then have to compete against these now quite cheap drugs in a competitive market. The newly discovered targets have functions beyond the cardiovascular system opening up novel therapeutic areas for drugs interfering with RAAS components.

Hybrid Al/steel-joints manufactured by ultrasound enhanced friction stir welding (USE-FSW): Process comparison, nondestructive testing and microscopic analysis

NASA Astrophysics Data System (ADS)

Thomä, M.; Wagner, G.; Straß, B.; Wolter, B.; Benfer, S.; Fürbeth, W.

2017-03-01

The process of friction stir welding (FSW) is an innovative joining technique, which proved its potential in joining dissimilar metals that are poorly fusion weldable. This ability opens a wide range for applications in industrial fields, where weight reduction by partial substitution of conventional materials through lightweight materials is a current central aim. As a consequence of this, the realization of aluminum / steel-joints is of great interest. For this material compound, several friction stir welds were carried out by different researchers for varying Al/steel-joints, whereas the definition of optimal process parameters as well as the increase of mechanical properties was in the focus of the studies. To achieve further improved properties for this dissimilar joint a newly developed hybrid process named “ultrasound enhanced friction stir welding (USE-FSW)” was applied. In this paper the resulting properties of Al/steel-joints using FSW and USE-FSW will be presented and compared. Furthermore, first results by using the nondestructive testing method “computer laminography” to analyze the developed joining area will be shown supplemented by detailed light-microscopic investigations, scanning electron microscopic analysis, and EDX.

Metamaterial superconductors

NASA Astrophysics Data System (ADS)

Smolyaninov, Igor I.; Smolyaninova, Vera N.

2018-05-01

Searching for natural materials exhibiting larger electron-electron interactions constitutes a traditional approach to high-temperature superconductivity research. Very recently, we pointed out that the newly developed field of electromagnetic metamaterials deals with the somewhat related task of dielectric response engineering on a sub-100-nm scale. Considerable enhancement of the electron-electron interaction may be expected in such metamaterial scenarios as in epsilon near-zero (ENZ) and hyperbolic metamaterials. In both cases, dielectric function may become small and negative in substantial portions of the relevant four-momentum space, leading to enhancement of the electron pairing interaction. This approach has been verified in experiments with aluminum-based metamaterials. Metamaterial superconductor with Tc=3.9 K have been fabricated, which is three times that of pure aluminum (Tc=1.2 K), which opens up new possibilities to improve the Tc of other simple superconductors considerably. Taking advantage of the demonstrated success of this approach, the critical temperature of hypothetical niobium, MgB2- and H2S-based metamaterial superconductors is evaluated. The MgB2-based metamaterial superconductors are projected to reach the liquid nitrogen temperature range. In the case of an H2S-based metamaterial, the projected Tc appears to reach 250 K.

Two-fluid 2.5D code for simulations of small scale magnetic fields in the lower solar atmosphere

NASA Astrophysics Data System (ADS)

Piantschitsch, Isabell; Amerstorfer, Ute; Thalmann, Julia Katharina; Hanslmeier, Arnold; Lemmerer, Birgit

2015-08-01

Our aim is to investigate magnetic reconnection as a result of the time evolution of magnetic flux tubes in the solar chromosphere. A new numerical two-fluid code was developed, which will perform a 2.5D simulation of the dynamics from the upper convection zone up to the transition region. The code is based on the Total Variation Diminishing Lax-Friedrichs method and includes the effects of ion-neutral collisions, ionisation/recombination, thermal/resistive diffusivity as well as collisional/resistive heating. What is innovative about our newly developed code is the inclusion of a two-fluid model in combination with the use of analytically constructed vertically open magnetic flux tubes, which are used as initial conditions for our simulation. First magnetohydrodynamic (MHD) tests have already shown good agreement with known results of numerical MHD test problems like e.g. the Orszag-Tang vortex test, the Current Sheet test or the Spherical Blast Wave test. Furthermore, the single-fluid approach will also be applied to the initial conditions, in order to compare the different rates of magnetic reconnection in both codes, the two-fluid code and the single-fluid one.

Cosmetic textiles with biological benefits: gelatin microcapsules containing vitamin C.

PubMed

Cheng, Shuk Yan; Yuen, Marcus Chun Wah; Kan, Chi Wai; Cheuk, Kevin Ka Leung; Chui, Chung Hin; Lam, Kim Hung

2009-10-01

In recent years, textile materials with special applications in the cosmetic field have been developed. A new sector of cosmetic textiles is opened up and several cosmetic textile products are currently available in the market. Microencapsulation technology is an effective technique to control the release properties of active ingredients that prolong the functionality of cosmetic textiles. This study discusses the development of cosmetic textiles and addresses microencapsulation technology with respect to its historical background, significant advantages, microencapsulation methods and recent applications in the textile industry. Gelatin microcapsules containing vitamin C were prepared using emulsion hardening technique. Both the optical microscopy and scanning electron microscopy demonstrated that the newly developed microcapsules were in the form of core-shell spheres with relatively smooth surface. The particle size of microcapsules ranged from 5.0 to 44.1 microm with the average particle size being 24.6 microm. The gelatin microcapsules were proved to be non-cytotoxic based on the research findings of the toxicity studies conducted on human liver and breast cell lines as well as primary bone marrow culture obtained from patient with non-malignant haematological disorder. The gelatin microcapsules were successfully grafted into textile materials for the development of cosmetic textiles.

Discovery potential for directional dark matter detection with nuclear emulsions

NASA Astrophysics Data System (ADS)

Guler, A. M.; NEWSdm Collaboration

2017-06-01

Direct Dark Matter searches are nowadays one of the most exciting research topics. Several Experimental efforts are concentrated on the development, construction, and operation of detectors looking for the scattering of target nuclei with Weakly Interactive Massive Particles (WIMPs). In this field a new frontier can be opened by directional detectors able to reconstruct the direction of the WIMP-recoiled nucleus thus allowing to extend dark matter searches beyond the neutrino floor. Exploiting directionality would also give a proof of the galactic origin of dark matter making it possible to have a clear and unambiguous signal to background separation. The angular distribution of WIPM-scattered nuclei is indeed expected to be peaked in the direction of the motion of the Solar System in the Galaxy, i.e. toward the Cygnus constellation, while the background distribution is expected to be isotropic. Current directional experiments are based on the use of gas TPC whose sensitivity is limited by the small achievable detector mass. In this paper we show the potentiality in terms of exclusion limit of a directional experiment based on the use of a solid target made by newly developed nuclear emulsions and read-out systems reaching sub-micrometric resolution.

Genetic algorithm optimized triply compensated pulses in NMR spectroscopy

NASA Astrophysics Data System (ADS)

Manu, V. S.; Veglia, Gianluigi

2015-11-01

Sensitivity and resolution in NMR experiments are affected by magnetic field inhomogeneities (of both external and RF), errors in pulse calibration, and offset effects due to finite length of RF pulses. To remedy these problems, built-in compensation mechanisms for these experimental imperfections are often necessary. Here, we propose a new family of phase-modulated constant-amplitude broadband pulses with high compensation for RF inhomogeneity and heteronuclear coupling evolution. These pulses were optimized using a genetic algorithm (GA), which consists in a global optimization method inspired by Nature's evolutionary processes. The newly designed π and π / 2 pulses belong to the 'type A' (or general rotors) symmetric composite pulses. These GA-optimized pulses are relatively short compared to other general rotors and can be used for excitation and inversion, as well as refocusing pulses in spin-echo experiments. The performance of the GA-optimized pulses was assessed in Magic Angle Spinning (MAS) solid-state NMR experiments using a crystalline U-13C, 15N NAVL peptide as well as U-13C, 15N microcrystalline ubiquitin. GA optimization of NMR pulse sequences opens a window for improving current experiments and designing new robust pulse sequences.

Field Evaluation of Open System Chambers for Measuring Whole Canopy Gas Exchanges

USDA-ARS?s Scientific Manuscript database

The ability to monitor whole canopy CO2 and H2O fluxes of crop plants in the field is needed for many research efforts ranging from plant breeding to the study of Climate Change effects on crops. Four portable, transparent, open system chambers for measuring canopy gas exchanges were field tested on...

Axisymmetric force-free magnetosphere in the exterior of a neutron star - II. Maximum storage and open field energies

NASA Astrophysics Data System (ADS)

Kojima, Yasufumi; Okamoto, Satoki

2018-04-01

A magnetar's magnetosphere gradually evolves by the injection of energy and helicity from the interior. Axisymmetric static solutions for a relativistic force-free magnetosphere with a power-law current model are numerically obtained. They provide information about the configurations in which the stored energy is large. The energy along a sequence of equilibria increases and becomes sufficient to open the magnetic field. A magnetic flux rope, in which a large amount of toroidal field is confined, is formed in the vicinity of the star, for states exceeding the open field energy. These states are energetically metastable, and the excess energy may be ejected as a magnetar outburst.

Behavior in the open field predicts the number of KCl-induced cortical spreading depressions in rats.

PubMed

Bogdanov, Volodymyr Borysovych; Bogdanova, Olena Viktorivna; Koulchitsky, Stanislav Vladimirovich; Chauvel, Virginie; Multon, Sylvie; Makarchuk, Mykola Yukhymovych; Brennan, Kevin Christopher; Renshaw, Perry Franklin; Schoenen, Jean

2013-01-01

Anxiety disorders are known to be comorbid with migraine, and cortical spreading depression (CSD) is the most likely cause of the migraine aura. To search for possible correlations between susceptibility to CSD and anxiety we used the open field test in male Sprague-Dawley rats chronically treated with the preventive anti-migraine drugs valproate or riboflavin. Animals avoiding the central area of the open field chamber and those with less exploratory activity (i.e. rearing) were considered more anxious. After 4 weeks of treatment CSDs were elicited by application of 1M KCl over the occipital cortex and the number of CSDs occurring over a 2h period was compared to the previously assessed open field behavior. Higher anxiety-like behavior was significantly correlated with a higher frequency of KCl-induced CSDs. In saline-treated animals, fewer rearings were found in animals with more frequent CSDs (R=-1.00). The duration of ambulatory episodes in the open field center correlated negatively with number of CSDs in the valproate group (R=-0.83; p<0.005) and in riboflavin treated group (R=-0.69; p<0.05) as well as total time spent in the open field center in both groups (R=-0.75; p<0.05 and R=-0.58; p<0.1 respectively). These results suggest that anxiety symptoms are associated with susceptibility to CSD and might explain why it can be an aggravating factor in migraine with aura. Copyright © 2012 Elsevier B.V. All rights reserved.

Modeling and simulation for the field emission of carbon nanotubes array

NASA Astrophysics Data System (ADS)

Wang, X. Q.; Wang, M.; Ge, H. L.; Chen, Q.; Xu, Y. B.

2005-12-01

To optimize the field emission of the infinite carbon nanotubes (CNTs) array on a planar cathode surface, the numerical simulation for the behavior of field emission with finite difference method was proposed. By solving the Laplace equation with computer, the influence of the intertube distance, the anode-cathode distance and the opened/capped CNT on the field emission of CNTs array were taken into account, and the results could accord well with the experiments. The simulated results proved that the field enhancement factor of individual CNT is largest, but the emission current density is little. Due to the enhanced screening of the electric field, the enhancement factor of CNTs array decreases with decreasing the intertube distance. From the simulation the field emission can be optimized when the intertube distance is close to the tube height. The anode-cathode distance hardly influences the field enhancement factor of CNTs array, but can low the threshold voltage by decreasing the anode-cathode distance. Finally, the distribution of potential of the capped CNTs array and the opened CNTs array was simulated, which the results showed that the distribution of potential can be influenced to some extent by the anode-cathode distance, especially at the apex of the capped CNTs array and the brim of the opened CNTs array. The opened CNTs array has larger field enhancement factor and can emit more current than the capped one.

Quasiopen inflation

NASA Astrophysics Data System (ADS)

García-Bellido, Juan; Garriga, Jaume; Montes, Xavier

1998-04-01

We show that a large class of two-field models of single-bubble open inflation does not lead to infinite open universes, as was previously thought, but to an ensemble of very large but finite inflating ``islands.'' The reason is that the quantum tunneling responsible for the nucleation of the bubble does not occur simultaneously along both field directions and equal-time hypersurfaces in the open universe are not synchronized with equal-density or fixed-field hypersurfaces. The most probable tunneling trajectory corresponds to a zero value of the inflaton field; large values, necessary for the second period of inflation inside the bubble, only arise as localized fluctuations. The interior of each nucleated bubble will contain an infinite number of such inflating regions of comoving size of order γ-1, where γ is the supercurvature eigenvalue, which depends on the parameters of the model. Each one of these islands will be a quasi-open universe. Since the volume of the hyperboloid is infinite, inflating islands with all possible values of the field at their center will be realized inside of a single bubble. We may happen to live in one of those patches of comoving size d<~γ-1, where the universe appears to be open. In particular, we consider the ``supernatural'' model proposed by Linde and Mezhlumian. There, an approximate U(1) symmetry is broken by a tunneling field in a first order phase transition, and slow-roll inflation inside the nucleated bubble is driven by the pseudo Goldstone field. We find that the excitations of the pseudo Goldstone field produced by the nucleation and subsequent expansion of the bubble place severe constraints on this model. We also discuss the coupled and uncoupled two-field models.

Field-antifield and BFV formalisms for quadratic systems with open gauge algebras

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nirov, K.S.; Razumov, A.V.

1992-09-20

In this paper the Lagrangian field-antifield (BV) and Hamiltonian (BFV) BRST formalisms for the general quadratic systems with open gauge algebra are considered. The equivalence between the Lagrangian and Hamiltonian formalisms is proven.

Evidence for open field lines in Jupiter's magnetosphere

NASA Technical Reports Server (NTRS)

Goertz, C. K.; Randall, B. A.; Thomsen, M. F.; Jones, D. E.; Smith, E. J.

1976-01-01

A model for the night-side Jovian magnetic field is derived partly on the basis of theoretical considerations and partly on the basis of the magnetic-field data obtained during the outbound leg of the path of Pioneer 10. This model can explain the observed sawtooth modulation of energetic particle fluxes in terms of closed and open field lines that cannot contain the particles. The model is applicable only to the Jovian magnetotail.

Transspinal direct current stimulation modulates migration and proliferation of adult newly born spinal cells in mice.

PubMed

Samaddar, Sreyashi; Vazquez, Kizzy; Ponkia, Dipen; Toruno, Pedro; Sahbani, Karim; Begum, Sultana; Abouelela, Ahmed; Mekhael, Wagdy; Ahmed, Zaghloul

2017-02-01

Direct current electrical fields have been shown to be a major factor in the regulation of cell proliferation, differentiation, migration, and survival, as well as in the maturation of dividing cells during development. During adulthood, spinal cord cells are continuously produced in both animals and humans, and they hold great potential for neural restoration following spinal cord injury. While the effects of direct current electrical fields on adult-born spinal cells cultured ex vivo have recently been reported, the effects of direct current electrical fields on adult-born spinal cells in vivo have not been characterized. Here, we provide convincing findings that a therapeutic form of transspinal direct current stimulation (tsDCS) affects the migration and proliferation of adult-born spinal cells in mice. Specifically, cathodal tsDCS attracted the adult-born spinal cells, while anodal tsDCS repulsed them. In addition, both tsDCS polarities caused a significant increase in cell number. Regarding the potential mechanisms involved, both cathodal and anodal tsDCS caused significant increases in expression of brain-derived neurotrophic factor, while expression of nerve growth factor increased and decreased, respectively. In the spinal cord, both anodal and cathodal tsDCS increased blood flow. Since blood flow and angiogenesis are associated with the proliferation of neural stem cells, increased blood flow may represent a major factor in the modulation of newly born spinal cells by tsDCS. Consequently, we propose that the method and novel findings presented in the current study have the potential to facilitate cellular, molecular, and/or bioengineering strategies to repair injured spinal cords. NEW & NOTEWORTHY Our results indicate that transspinal direct current stimulation (tsDCS) affects the migratory pattern and proliferation of adult newly born spinal cells, a cell population which has been implicated in learning and memory. In addition, our results suggest a potential mechanism of action regarding the functional effects of applying direct current. Thus tsDCS may represent a novel method by which to manipulate the migration and cell number of adult newly born cells and restore functions following brain or spinal cord injury. Copyright © 2017 the American Physiological Society.

SYBR green-based one step quantitative real-time polymerase chain reaction assay for the detection of Zika virus in field-caught mosquitoes.

PubMed

Tien, Wei-Ping; Lim, Gareth; Yeo, Gladys; Chiang, Suzanna Nicole; Chong, Chee-Seng; Ng, Lee-Ching; Hapuarachchi, Hapuarachchige Chanditha

2017-09-19

The monitoring of vectors is one of the key surveillance measures to assess the risk of arbovirus transmission and the success of control strategies in endemic regions. The recent re-emergence of Zika virus (ZIKV) in the tropics, including Singapore, emphasizes the need to develop cost-effective, rapid and accurate assays to monitor the virus spread by mosquitoes. As ZIKV infections largely remain asymptomatic, early detection of ZIKV in the field-caught mosquitoes enables timely implementation of appropriate mosquito control measures. We developed a rapid, sensitive and specific real-time reverse transcription polymerase chain reaction (rRT-PCR) assay for the detection of ZIKV in field-caught mosquitoes. The primers and PCR cycling conditions were optimized to minimize non-specific amplification due to cross-reactivity with the genomic material of Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, Culex tritaeniorhynchus, Culex sitiens and Anopheles sinensis, as well as accompanying microbiota. The performance of the assay was further evaluated with a panel of flaviviruses and alphaviruses as well as in field-caught Ae. aegypti mosquitoes confirmed to be positive for ZIKV. As compared to a probe-based assay, the newly developed assay demonstrated 100% specificity and comparable detection sensitivity for ZIKV in mosquitoes. Being a SYBR Green-based method, the newly-developed assay is cost-effective and easy to adapt, thus is applicable to large-scale vector surveillance activities in endemic countries, including those with limited resources and expertise. The amplicon size (119 bp) also allows sequencing to confirm the virus type. The primers flank relatively conserved regions of ZIKV genome, so that, the assay is able to detect genetically diverse ZIKV strains. Our findings, therefore, testify the potential use of the newly-developed assay in vector surveillance programmes for ZIKV in endemic regions.

Re-Invigorating Openness at The Open University: The Role of Open Educational Resources

ERIC Educational Resources Information Center

Gourley, Brenda; Lane, Andy

2009-01-01

This paper describes the internal motivations and external drivers that led The Open University UK to enter the field of Open Educational Resources through its institution-wide OpenLearn initiative (www.open.ac.uk/openlearn). It also describes some of the emerging evidence of the impacts inside and outside the university. Through the rapid…

HLA-F and MHC-I Open Conformers Cooperate in a MHC-I Antigen Cross-Presentation Pathway

PubMed Central

Goodridge, Jodie P.; Lee, Ni; Burian, Aura; Pyo, Chul-Woo; Tykodi, Scott S.; Warren, Edus H.; Yee, Cassian; Riddell, Stanley R.

2013-01-01

Peptides that are presented by MHC class I (MHC-I) are processed from two potential sources, as follows: newly synthesized endogenous proteins for direct presentation on the surface of most nucleated cells and exogenous proteins for cross-presentation typically by professional APCs. In this study, we present data that implicate the nonclassical HLA-F and open conformers of MHC-I expressed on activated cells in a pathway for the presentation of exogenous proteins by MHC-I. This pathway is distinguished from the conventional endogenous pathway by its independence from TAP and tapasin and its sensitivity to inhibitors of lysosomal enzymes, and further distinguished by its dependence on MHC-I allotype-specific epitope recognition for Ag uptake. Thus, our data from in vitro experiments collectively support a previously unrecognized model of Ag cross-presentation mediated by HLA-F and MHC-I open conformers on activated lymphocytes and monocytes, which may significantly contribute to the regulation of immune system functions and the immune defense. PMID:23851683

Cosmonaut Krikalev with IMAX camera prior to hatch opening

NASA Image and Video Library

2001-02-11

STS98-E-5124 (11 February 2001) --- Cosmonaut Sergei K. Krikalev, Expedition One flight engineer representing the Russian Aviation and Space Agency, films activity in the Unity node, just outside the newly attached Destiny laboratory. The crews of Atlantis and the International Space Station on February 11 opened the Destiny laboratory and spent the first full day of what are planned to be years of work ahead inside the orbiting science and command center. Astronaut William M. (Bill) Shepherd (just out of frame here) opened the Destiny hatch, and he and Shuttle commander Kenneth D. Cockrell ventured inside at 8:38 a.m. (CST). Members of both crews went to work quickly inside the new module, activating air systems, fire extinguishers, alarm systems, computers and internal communications. The crew also continued equipment transfers from the shuttle to the station and filmed several scenes onboard the station using the IMAX camera. This scene was recorded with a digital still camera.

Astronauts Cockrell, Shepherd and Polansky prior to opening hatch

NASA Image and Video Library

2001-02-11

STS98-E-5123 (11 February 2001) --- This digital still camera shot shows STS-98 mission commander Kenneth D. Cockrell (from left), Expedition One commander William M. (Bill) Shepherd and STS-98 pilot Mark L. Polansky pausing at Unity's closed hatch to the newly attached Destiny laboratory. The crews of Atlantis and the International Space Station opened the laboratory shortly after this photo was made on Feb. 11; and the astronauts and cosmonauts spent the first full day of what are planned to be years of work ahead inside the orbiting science and command center. Shepherd opened the Destiny hatch, and he and shuttle commander Cockrell ventured inside at 8:38 a.m. (CST), Feb. 11. As depicted in subsequent digital images in this series, members of both crews went to work quickly inside the new module, activating air systems, fire extinguishers, alarm systems, computers and internal communications. The crew also continued equipment transfers from the shuttle to the station.

GENERIC VERIFICATION PROTOCOL: DISTRIBUTED GENERATION AND COMBINED HEAT AND POWER FIELD TESTING PROTOCOL

EPA Science Inventory

This report is a generic verification protocol by which EPA’s Environmental Technology Verification program tests newly developed equipment for distributed generation of electric power, usually micro-turbine generators and internal combustion engine generators. The protocol will ...

Differences between the quality of strawberries (Fragaria x ananassa) pollinated by the stingless bees Scaptotrigona aff. depilis and Nannotrigona testaceicornis.

PubMed

Roselino, A C; Santos, S B; Hrncir, M; Bego, L R

2009-05-12

We investigated the success of two stingless bee species in pollinating strawberries in greenhouses. Three greenhouses and one open field area were used; one greenhouse had only strawberry plants (control), another (G1) had three colonies of Scaptotrigona aff. depilis and another (G2) had three colonies of Nannotrigona testaceicornis. In the open field area, the flowers could be visited by any bee. The total production of fruits was counted and a random sample (N = 100) from each area was used to measure weight, length, circumference, and achenes number (N = 5). The percentages of deformed strawberries were: 23% (no bees); 2% (greenhouses with bees) and 13% (open field). The strawberries from the greenhouse with N. testaceicornis and the open field were heavier than those from the greenhouses with no bees and with S. depilis. The fruit circumference was largest in the greenhouses with bees. The achenes number did not differ among the experimental areas. The strawberries produced in the greenhouses with stingless bees had more quality and greater commercial value than the fruits produced in the open field area and the greenhouse without bees. We conclude that stingless bees are efficient pollinators of strawberry flowers cultivated in greenhouses.

Antioxidant effects of nerolidol in mice hippocampus after open field test.

PubMed

Nogueira Neto, José Damasceno; de Almeida, Antonia Amanda Cardoso; da Silva Oliveira, Johanssy; Dos Santos, Pauline Sousa; de Sousa, Damião Pergentino; de Freitas, Rivelilson Mendes

2013-09-01

The aim of this study was to evaluate the neuroprotective effects of nerolidol in mice hippocampus against oxidative stress in neuronal cells compared to ascorbic acid (positive control) as well as evaluated the nerolidol sedative effects by open field test compared to diazepam (positive control). Thirty minutes prior to behavioral observation on open field test, mice were intraperitoneally treated with vehicle, nerolidol (25, 50 and 75 mg/kg), diazepam (1 mg/kg) or ascorbic acid (250 mg/kg). To clarify the action mechanism of of nerolidol on oxidative stress in animals subjected to the open field test, Western blot analysis of Mn-superoxide dismutase and catalase in mice hippocampus were performed. In nerolidol group, there was a significant decrease in lipid peroxidation and nitrite levels when compared to negative control (vehicle). However, a significant increase was observed in superoxide dismutase and catalase activities in this group when compared to the other groups. Vehicle, diazepam, ascorbic acid and nerolidol groups did not affected Mn-superoxide dismutase, catalase mRNA or protein levels. Our findings strongly support the hypothesis that oxidative stress occurs in hippocampus. Nerolidol showed sedative effects in animals subjected to the open field test. Oxidative process plays a crucial role on neuronal pathological consequence, and implies that antioxidant effects could be achieved using this sesquiterpene.

Results of Gravity Fieldwork Conducted in March 2008 in the Moapa Valley Region of Clark County, Nevada

USGS Publications Warehouse

Scheirer, Daniel S.; Andreasen, Arne Dossing

2008-01-01

In March 2008, we collected gravity data along 12 traverses across newly-mapped faults in the Moapa Valley region of Clark County, Nevada. In areas crossed by these faults, the traverses provide better definition of the gravity field and, thus, the density structure, than prior gravity observations. Access problems prohibited complete gravity coverage along all of the planned gravity traverses, and we added and adjusted the locations of traverses to maximize our data collection. Most of the traverses exhibit isostatic gravity anomalies that have gradients characteristic of exposed or buried faults, including several of the newly-mapped faults.

A possible propellantless propulsion system

NASA Astrophysics Data System (ADS)

Goodwin, David P.

2001-02-01

A newly developed high power solid state switch might have enabled a propellantless propulsion system (PPS), based on the Lenz's Law interactions of a very rapidly pulsed magnet. Although only limited propulsion would be provided with each pulse, and then only during the 100-nanosecond ramp-up of the pulse, the newly developed switch produces 400,000 high power pulses per second. A PPS of this type would consist of an electrical power supply, the switch, and a solenoid with a plate on one end to produce an asymmetry in the magnetic field. Other applications might include propulsion with reduced thermal and acoustical signatures, and a means to dampen inertia. .

Identifying a cooperative control mechanism between an applied field and the environment of open quantum systems

NASA Astrophysics Data System (ADS)

Gao, Fang; Rey-de-Castro, Roberto; Wang, Yaoxiong; Rabitz, Herschel; Shuang, Feng

2016-05-01

Many systems under control with an applied field also interact with the surrounding environment. Understanding the control mechanisms has remained a challenge, especially the role played by the interaction between the field and the environment. In order to address this need, here we expand the scope of the Hamiltonian-encoding and observable-decoding (HE-OD) technique. HE-OD was originally introduced as a theoretical and experimental tool for revealing the mechanism induced by control fields in closed quantum systems. The results of open-system HE-OD analysis presented here provide quantitative mechanistic insights into the roles played by a Markovian environment. Two model open quantum systems are considered for illustration. In these systems, transitions are induced by either an applied field linked to a dipole operator or Lindblad operators coupled to the system. For modest control yields, the HE-OD results clearly show distinct cooperation between the dynamics induced by the optimal field and the environment. Although the HE-OD methodology introduced here is considered in simulations, it has an analogous direct experimental formulation, which we suggest may be applied to open systems in the laboratory to reveal mechanistic insights.

Interior of the U.S. Laboratory / Destiny module

NASA Image and Video Library

2001-02-11

STS98-E-5113 (11 February 2001) --- This wide shot, photographed with a digital still camera, shows the interior of the newly attached Destiny laboratory. The crews of Atlantis and the International Space Station opened the laboratory on Feb. 11 and spent the first full day of what are planned to be years of work ahead inside the orbiting science and command center. Station commander William M. (Bill) Shepherd opened the Destiny hatch, and he and shuttle commander Kenneth D. Cockrell ventured inside at 8:38 a.m. (CST), Feb. 11. As depicted in subsequent digital images in this series, members of both crews went to work quickly inside the new module, activating air systems, fire extinguishers, alarm systems, computers and internal communications. The crew also continued equipment transfers from the shuttle to the station.

LLNL Small-Scale Friction sensitivity (BAM) Test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simpson, L.R.; Foltz, M.F.

1996-06-01

Small-scale safety testing of explosives, propellants and other energetic materials, is done to determine their sensitivity to various stimuli including friction, static spark, and impact. Testing is done to discover potential handling problems for either newly synthesized materials of unknown behavior, or materials that have been stored for long periods of time. This report describes the existing {open_quotes}BAM{close_quotes} Small-Scale Friction Test, and the methods used to determine the friction sensitivity pertinent to handling energetic materials. The accumulated data for the materials tested is not listed here - that information is in a database. Included is, however, a short list ofmore » (1) materials that had an unusual response, and (2), a few {open_quotes}standard{close_quotes} materials representing the range of typical responses usually seen.« less

Newly defined aberrant crypt foci as a marker for dysplasia in the rat colon

PubMed Central

Ochiai, Masako; Hippo, Yoshitaka; Izumiya, Masashi; Watanabe, Masatoshi; Nakagama, Hitoshi

2014-01-01

Dysplasia represents a preneoplastic status in multistep colon carcinogenesis. Whereas laborious preparation of thin sections is required for its diagnosis, we here show that newly defined aberrant crypt foci (ACF) simply mark the majority of the dysplasia on the whole colon. Specifically, decoloring of the azoxymethane-treated rat colon after scoring classical ACF (cACF) resulted in visualization of a subset of aberrant crypts that remained densely stained. They were morphologically classified into three subtypes, of which two with compressed luminal openings proved highly correlated with dysplasia. Accordingly, we designated those foci harboring either of the two crypt subtypes as dysplasia-associated ACF (dACF). By serially applying different detection methods for known preneoplastic lesions to the same colon, we showed that most dACF had already been identified as cACF, and a few newly identified dACF contained an entire population of more advanced lesions, such as flat ACF and mucin-depleted foci. Consequently, integrative scoring of cACF and dACF enabled capture of all early lesions of the colon. Furthermore, 94% of the dACF showed dysplasia and 90% of the dysplastic lesions proved to be dACF. Thus, dACF is a promising marker for dysplasia, likely facilitating precise identification of the early stages of colon carcinogenesis. PMID:24827115

Physical and emotional well-being and support in newly diagnosed head and neck cancer patient-caregiver dyads.

PubMed

Sterba, Katherine R; Zapka, Jane; Armeson, Kent E; Shirai, Keisuke; Buchanan, Amy; Day, Terry A; Alberg, Anthony J

2017-01-01

The purpose of this study was to examine the physical and emotional well-being and social support in newly diagnosed head and neck cancer (HNC) patients and caregivers and identify sociodemographic, clinical, and behavioral risk factors associated with compromised well-being in patients and caregivers. Newly diagnosed HNC patients and their primary caregivers (N = 72 dyads) completed questionnaires before treatment assessing physical and mental well-being, depression, cancer worry, and open-ended support questions. Patients reported worse physical well-being than caregivers (p < 0.05) but similar levels of mental well-being. Caregivers reported providing emotional and instrumental support most frequently with an emphasis on nutrition and assistance with speech, appearance, and addictions. Both patients and their caregivers reported suboptimal mental well-being and depression. Smoking was associated with compromised well-being in patients, caregivers, and dyads. Compromised well-being in patients and their caregivers was more likely when patients were younger, had worse symptoms, and smoked/consumed alcohol (p < 0.05). While patients face more physical strain than caregivers, both equally confront emotional challenges. Results highlight risk factors for compromised well-being in both patients and their caregivers that should be assessed at diagnosis to guide identification of needed dyadic-focused supportive care resources.

Open field locomotor activity and anxiety-related behaviors in mucopolysaccharidosis type IIIA mice.

PubMed

Lau, Adeline A; Crawley, Allison C; Hopwood, John J; Hemsley, Kim M

2008-08-05

Mucopolysaccharidosis (MPS) IIIA, or Sanfilippo syndrome, is a lysosomal storage disorder characterized by severe and progressive neuropathology. Following an asymptomatic period, patients may present with sleep disturbances, cognitive decline, aggressive tendencies and hyperactivity. A naturally-occurring mouse model of MPS IIIA also exhibits many of these behavioral features and has been recently back-crossed onto a C57BL/6 genetic background. To more thoroughly characterize the behavioral phenotype of congenic MPS IIIA mice, we assessed exploratory activity and unconditioned anxiety-related behavior in the elevated plus maze (EPM) and open field locomotor activity. Although MPS IIIA male mice were less active in the EPM at 18 and 20 weeks of age, they were more likely to explore the open arms than their normal counter-parts suggesting reduced anxiety. Repeated EPM testing reduced exploration of the open arms in MPS IIIA mice. In the open field test, significant reductions in activity were evident in naïve-tested male MPS IIIA mice from 10 weeks of age. Female normal and MPS IIIA mice displayed similar exploratory activity in the open field test. These differences in anxiety and locomotor activity will allow us to evaluate the efficacy of therapeutic regimes for MPS IIIA as a forerunner to developing safe and effective therapies for Sanfilippo patients.

The same frequency of planets inside and outside open clusters of stars.

PubMed

Meibom, Søren; Torres, Guillermo; Fressin, Francois; Latham, David W; Rowe, Jason F; Ciardi, David R; Bryson, Steven T; Rogers, Leslie A; Henze, Christopher E; Janes, Kenneth; Barnes, Sydney A; Marcy, Geoffrey W; Isaacson, Howard; Fischer, Debra A; Howell, Steve B; Horch, Elliott P; Jenkins, Jon M; Schuler, Simon C; Crepp, Justin

2013-07-04

Most stars and their planets form in open clusters. Over 95 per cent of such clusters have stellar densities too low (less than a hundred stars per cubic parsec) to withstand internal and external dynamical stresses and fall apart within a few hundred million years. Older open clusters have survived by virtue of being richer and denser in stars (1,000 to 10,000 per cubic parsec) when they formed. Such clusters represent a stellar environment very different from the birthplace of the Sun and other planet-hosting field stars. So far more than 800 planets have been found around Sun-like stars in the field. The field planets are usually the size of Neptune or smaller. In contrast, only four planets have been found orbiting stars in open clusters, all with masses similar to or greater than that of Jupiter. Here we report observations of the transits of two Sun-like stars by planets smaller than Neptune in the billion-year-old open cluster NGC6811. This demonstrates that small planets can form and survive in a dense cluster environment, and implies that the frequency and properties of planets in open clusters are consistent with those of planets around field stars in the Galaxy.

Optical observations of MAXI J1820+070 suggest it is a black hole X-ray binary

NASA Astrophysics Data System (ADS)

Baglio, M. Cristina; Russell, Dave M.; Lewis, Fraser

2018-03-01

We report on optical observations of the newly discovered transient MAXI J1820+070 (ATel #11399, #11400, #11403, #11404, #11406). We performed optical (g', i') observations of the field with the Las Cumbres Observatory (LCO) 1-m robotic telescope located at Cerro Tololo Inter-American Observatory, Chile, on March 13th, 2018 (MJD 58190.38) obtaining one 200-second integration image of the field for each filter.

Myocardial infarction increases progressive visual field defects in well treated early primary open angle glaucoma--a prospective case control study.

PubMed

Mondal, Lakshmikanta; Baidya, Krishnapada; Choudhury, Himadri; Roy, Rupam

2013-06-01

The purpose of the study was to evaluate the progression of glaucomatous field damage in patients with stable primary open angle glaucoma after an attack of myocardial infarction. In this case control study, 62 open angle glaucoma patients were selected and regularly followed up. Among 62 patients, 9 had an attack of myocardial infarction. The intra-ocular pressure and visual field progression of both the groups (myocardial infarction versus no myocardial infarction) were analysed. Three (33.3%) out of 9 patients who had suffered from myocardial infarction showed progressive visual field loss whereas only 9 (16.9%) out of 53 patients who did not suffer from myocardial infarction, showed progressive field changes. Both the groups had stable target intra-ocular pressure between 14 and 16 mm Hg. Myocardial infarction may adversely influence the progression of primary open angle glaucoma which is suspected to result from ischaemia induced neuronal loss and only control of intraocular pressure is not the only solution. We have to look for other drugs that prevents ischaemia induced neuronal damage.

The source of the electric field in the nightside magnetosphere

NASA Technical Reports Server (NTRS)

Stern, D. P.

1975-01-01

In the open magnetosphere model magnetic field lines from the polar caps connect to the interplanetary magnetic field and conduct an electric field from interplanetary space to the polar ionosphere. By examining the magnetic flux involved it is concluded that only slightly more than half of the magnetic flux in the polar caps belongs to open field lines and that such field lines enter or leave the magnetosphere through narrow elongated windows stretching the tail. These window regions are identified with the tail's boundary region and shift their position with changes in the interplanetary magnetic field, in particular when a change of interplanetary magnetic sector occurs. The circuit providing electric current in the magnetopause and the plasma sheet is extended across those windows; thus energy is drained from the interplanetary electric field and an electric potential drop is produced across the plasma sheet. The polar cap receives its electric field from interplanetary space on the day side from open magnetic field lines and on the night side from closed field lines leading to the plasma sheet. The theory described provides improved understanding of magnetic flux bookkeeping, of the origin of Birkeland currents, and of the boundary layer of the geomagnetic tail.

Focused feasibility study for surface soil at the main pits and pushout area, J-field toxic burning pits area, Aberdeen Proving Ground, Maryland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patton, T.; Benioff, P.; Biang, C.

1996-06-01

The Environmental Management Division of Aberdeen Proving Ground (APG), Maryland, is conducting a remedial investigation and feasibility study of the J-Field area at APG pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act, as amended (CERCLA). J-Field is located within the Edgewood Area of APG in Harford County, Maryland. Since World War II, activities in the Edgewood Area have included the development, manufacture, testing, and destruction of chemical agents and munitions. These materials were destroyed at J-Field by open burning/open detonation. Portions of J-Field continue to be used for the detonation and disposal of unexploded ordnance (UXO) by openmore » burning/open detonation under authority of the Resource Conservation and Recovery Act.« less

Development of a real-time wave field reconstruction TEM system (II): correction of coma aberration and 3-fold astigmatism, and real-time correction of 2-fold astigmatism.

PubMed

Tamura, Takahiro; Kimura, Yoshihide; Takai, Yoshizo

2018-02-01

In this study, a function for the correction of coma aberration, 3-fold astigmatism and real-time correction of 2-fold astigmatism was newly incorporated into a recently developed real-time wave field reconstruction TEM system. The aberration correction function was developed by modifying the image-processing software previously designed for auto focus tracking, as described in the first article of this series. Using the newly developed system, the coma aberration and 3-fold astigmatism were corrected using the aberration coefficients obtained experimentally before the processing was carried out. In this study, these aberration coefficients were estimated from an apparent 2-fold astigmatism induced under tilted-illumination conditions. In contrast, 2-fold astigmatism could be measured and corrected in real time from the reconstructed wave field. Here, the measurement precision for 2-fold astigmatism was found to be ±0.4 nm and ±2°. All of these aberration corrections, as well as auto focus tracking, were performed at a video frame rate of 1/30 s. Thus, the proposed novel system is promising for quantitative and reliable in situ observations, particularly in environmental TEM applications.

An improved design method of a tuned mass damper for an in-service footbridge

NASA Astrophysics Data System (ADS)

Shi, Weixing; Wang, Liangkun; Lu, Zheng

2018-03-01

Tuned mass damper (TMD) has a wide range of applications in the vibration control of footbridges. However, the traditional engineering design method may lead to a mistuned TMD. In this paper, an improved TMD design method based on the model updating is proposed. Firstly, the original finite element model (FEM) is studied and the natural characteristics of the in-service or newly built footbridge is identified by field test, and then the original FEM is updated. TMD is designed according to the new updated FEM, and it is optimized according to the simulation on vibration control effects. Finally, the installation and field measurement of TMD are carried out. The improved design method can be applied to both in-service and newly built footbridges. This paper illustrates the improved design method with an engineering example. The frequency identification results of field test and original FEM show that there is a relatively large difference between them. The TMD designed according to the updated FEM has better vibration control effect than the TMD designed according to the original FEM. The site test results show that TMD has good effect on controlling human-induced vibrations.

Integrating HIV Surveillance and Field Services: Data Quality and Care Continuum in King County, Washington, 2010-2015.

PubMed

Hood, Julia E; Katz, David A; Bennett, Amy B; Buskin, Susan E; Dombrowski, Julia C; Hawes, Stephen E; Golden, Matthew R

2017-12-01

To assess how integration of HIV surveillance and field services might influence surveillance data and linkage to care metrics. We used HIV surveillance and field services data from King County, Washington, to assess potential impact of misclassification of prior diagnoses on numbers of new diagnoses. The relationship between partner services and linkage to care was evaluated with multivariable log-binomial regression models. Of the 2842 people who entered the King County HIV Surveillance System in 2010 to 2015, 52% were newly diagnosed, 41% had a confirmed prior diagnosis in another state, and 7% had an unconfirmed prior diagnosis. Twelve percent of those classified as newly diagnosed for purposes of national HIV surveillance self-reported a prior HIV diagnosis that was unconfirmed. Partner services recipients were more likely than nonrecipients to link to care within 30 days (adjusted risk ratio [RR] = 1.10; 95% confidence interval [CI] = 1.03, 1.18) and 90 days (adjusted RR = 1.07; 95% CI = 1.01, 1.14) of diagnosis. Integration of HIV surveillance, partner services, and care linkage efforts may improve the accuracy of HIV surveillance data and facilitate timely linkage to care.

MS Ivins floats through U.S. Laboratory / Destiny module

NASA Image and Video Library

2001-02-11

STS98-E-5161 (11 February 2001) --- Astronaut Marsha S. Ivins, STS-98 mission specialist, floats into the newly attached Destiny laboratory onboard the International Space Station (ISS). After the Destiny hatch was opened early in the day, members of both crews went to work quickly inside the new module, activating air systems, fire extinguishers, alarm systems, computers and internal communications. The crews also took some photos and continued equipment transfers from the shuttle to the station. The scene was taken with a digital still camera.

CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

PubMed Central

Guo, Ke-Tai; Paul, Angela; Schichor, Christian; Ziemer, Gerhard; Wendel, Hans P.

2008-01-01

Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers. PMID:19325777

Translations on Eastern Europe, Scientific Affairs, Number 531

DTIC Science & Technology

1976-12-20

half now music therapy has been one of the meth- ods of treatment that we employ in the newly opened psychotherapy room of our hospital. The choice...of music from the preclassics was made by spe- cialists. In the course of music therapy we select a group of six pa- tients suffering from neuroses...decision was made to introduce music therapy as a mass method of treatment in hospitals. But for the present this decision remains in the minutes of

Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial.

PubMed

Gore, Lia; Kearns, Pamela R; de Martino, Maria Lucia; Lee; De Souza, Carmino Antonio; Bertrand, Yves; Hijiya, Nobuko; Stork, Linda C; Chung, Nack-Gyun; Cardos, Rocio Cardenas; Saikia, Tapan; Fagioli, Franca; Seo, Jong Jin; Landman-Parker, Judith; Lancaster, Donna; Place, Andrew E; Rabin, Karen R; Sacchi, Mariana; Swanink, Rene; Zwaan, C Michel

2018-05-01

Purpose Safe, effective treatments are needed for pediatric patients with chronic myeloid leukemia in chronic phase (CML-CP). Dasatinib is approved for treatment of adults and children with CML-CP. A phase I study determined suitable dosing for children with Philadelphia chromosome-positive (Ph+) leukemias. Methods CA180-226/NCT00777036 is a phase II, open-label, nonrandomized prospective trial of patients < 18 years of age receiving dasatinib. There are three cohorts: (1) imatinib-resistant/intolerant CML-CP, (2) imatinib-resistant/intolerant CML in accelerated/blast phase or Ph+ acute lymphoblastic leukemia (n = 17), and (3) newly diagnosed CML-CP treated with tablets or powder for oral suspension. Major cytogenetic response > 30% for imatinib-resistant/intolerant patients and complete cytogenetic response (CCyR) > 55% for newly diagnosed patients were of clinical interest. Results Of 113 patients with CML-CP, 14 (48%) who were imatinib-resistant/intolerant and 61 (73%) who were newly diagnosed remained on treatment at time of analysis. Major cytogenetic response > 30% was reached by 3 months in the imatinib-resistant/intolerant group and CCyR > 55% was reached by 6 months in the newly diagnosed CML-CP group. CCyR and major molecular response by 12 months, respectively, were 76% and 41% in the imatinib-resistant/intolerant group and 92% and 52% in newly diagnosed CML-CP group. Progression-free survival by 48 months was 78% and 93% in the imatinib-resistant/intolerant and newly diagnosed CML-CP groups, respectively. No dasatinib-related pleural or pericardial effusion, pulmonary edema, or pulmonary arterial hypertension were reported. Bone growth and development events were reported in 4% of patients. Conclusion In the largest prospective trial to date in children with CML-CP, we demonstrate that dasatinib is a safe, effective treatment of pediatric CML-CP. Target responses to first- or second-line dasatinib were met early, and deep molecular responses were observed. Safety of dasatinib in pediatric patients was similar to that observed in adults; however, no cases of pleural or pericardial effusion or pulmonary arterial hypertension were reported.

A System for Open-Access 3He Human Lung Imaging at Very Low Field

PubMed Central

RUSET, I.C.; TSAI, L.L.; MAIR, R.W.; PATZ, S.; HROVAT, M.I.; ROSEN, M.S.; MURADIAN, I.; NG, J.; TOPULOS, G.P.; BUTLER, J.P.; WALSWORTH, R.L.; HERSMAN, F.W.

2010-01-01

We describe a prototype system built to allow open-access very-low-field MRI of human lungs using laser-polarized 3He gas. The system employs an open four-coil electromagnet with an operational B0 field of 4 mT, and planar gradient coils that generate gradient fields up to 0.18 G/cm in the x and y direction and 0.41 G/cm in the z direction. This system was used to obtain 1H and 3He phantom images and supine and upright 3He images of human lungs. We include discussion on challenges unique to imaging at 50 –200 kHz, including noise filtering and compensation for narrow-bandwidth coils. PMID:20354575

Impact of a Casino Opening on Gambling Behaviors of People Engaged in Methadone Maintenance.

PubMed

Palmer-Bacon, Jessica; Miles-McLean, Haley; Welsh, Christopher; Rugle, Loreen; Medoff, Deborah; Potts, Wendy; Himelhoch, Seth

2017-06-01

This study examined gambling behavior in the context of a newly opening casino, comparing disordered gamblers to non-disordered gamblers, in a population of individuals involved in methadone maintenance treatment. Disordered gamblers (N = 50) and non-disordered gamblers (N = 50) were surveyed before and after the opening of a new casino on gambling behaviors, substance use, and psychological symptoms. No statistically significant changes in gambling behaviors were observed for disordered gamblers or non-disordered gamblers across time points; however, non-disordered gamblers demonstrated non-significant increases in horse and dog race betting, electronic games, and casino table games. As expected, disordered gamblers were found to spend significantly more money on electronic games and casino table games (p < 0.05) and demonstrated higher rates of drug use and impulsivity than non-disordered gamblers. The introduction of a new casino did not appear to have a major impact on gambling behaviors of individuals attending methadone maintenance treatment, though the non-significant increases in gambling among non-disordered gamblers may indicate that this population is preferentially impacted by the opening of a new casino. Future investigation into the longer term effects of opening a new casino on this population may be warranted.

A Human Open Field Test Reveals Thigmotaxis Related to Agoraphobic Fear.

PubMed

Walz, Nora; Mühlberger, Andreas; Pauli, Paul

2016-09-01

Thigmotaxis refers to a specific behavior of animals (i.e., to stay close to walls when exploring an open space). Such behavior can be assessed with the open field test (OFT), which is a well-established indicator of animal fear. The detection of similar open field behavior in humans may verify the translational validity of this paradigm. Enhanced thigmotaxis related to anxiety may suggest the relevance of such behavior for anxiety disorders, especially agoraphobia. A global positioning system was used to analyze the behavior of 16 patients with agoraphobia and 18 healthy individuals with a risk for agoraphobia (i.e., high anxiety sensitivity) during a human OFT and compare it with appropriate control groups (n = 16 and n = 19). We also tracked 17 patients with agoraphobia and 17 control participants during a city walk that involved walking through an open market square. Our human OFT triggered thigmotaxis in participants; patients with agoraphobia and participants with high anxiety sensitivity exhibited enhanced thigmotaxis. This behavior was evident in increased movement lengths along the wall of the natural open field and fewer entries into the center of the field despite normal movement speed and length. Furthermore, participants avoided passing through the market square during the city walk, indicating again that thigmotaxis is related to agoraphobia. This study is the first to our knowledge to verify the translational validity of the OFT and to reveal that thigmotaxis, an evolutionarily adaptive behavior shown by most species, is related to agoraphobia, a pathologic fear of open spaces, and anxiety sensitivity, a risk factor for agoraphobia. Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

The stimulatory effects of caffeine with oseltamivir (Tamiflu) on light-dark behavior and open-field behavior in mice.

PubMed

Uchiyama, Hidemori; Toda, Akihisa; Imoto, Masumi; Nishimura, Satoko; Kuroki, Hiroaki; Soeda, Shinji; Shimeno, Hiroshi; Watanabe, Shigenori; Eyanagi, Reiko

2010-01-22

Abnormal behaviors and death associated with the use of oseltamivir (Tamiflu) have emerged as a major issue in influenza patients taking the drug. Here, we investigated the mechanisms underlying the effects of oseltamivir on the behavior of mice using light-dark and open-field preference tests. Oseltamivir (75 and 150 mg/kg, intraperitoneally (i.p.)) alone affected neither time spent in the open area in the light-dark preference test nor ambulation in the open-field test at 2h post-injection. However, a non-selective adenosine A(1)/A(2) receptor antagonist, caffeine (10mg/kg, i.p.) in combination with oseltamivir (150 mg/kg, i.p.) increased time spent in the open area in the light-dark preference test. This enhancement was not inhibited by a benzodiazepine receptor antagonist, flumazenil (10-20mg/kg, subcutaneously (s.c.)). Enhancement of ambulation in the open-field test was also observed when caffeine (10mg/kg, i.p.) was combined with oseltamivir (150 mg/kg, i.p.). This enhancement was inhibited by a dopamine D(2) receptor antagonist, haloperidol (0.1mg/kg, s.c.). Furthermore, an adenosine A(2) receptor antagonist, SCH58261 (3mg/kg, i.p.) in combination with oseltamivir (150 mg/kg, i.p.) increased ambulation in the open-field test, while an adenosine A(1) receptor antagonist, DPCPX (1-3mg/kg, i.p.) did not. These findings suggest that the actions of oseltamivir may involve the dopamine and adenosine systems. Our findings suggest that due to the interaction between central blockade of adenosine A(2) receptors by caffeine, and oseltamivir-induced behavioral changes, patients being treated with oseltamivir should be closely monitored. (c) 2009 Elsevier Ireland Ltd. All rights reserved.

Exploratory behaviour in the open field test adapted for larval zebrafish: impact of environmental complexity.

PubMed

Ahmad, Farooq; Richardson, Michael K

2013-01-01

This study aimed to develop and characterize a novel (standard) open field test adapted for larval zebrafish. We also developed and characterized a variant of the same assay consisting of a colour-enriched open field; this was used to assess the impact of environmental complexity on patterns of exploratory behaviours as well to determine natural colour preference/avoidance. We report the following main findings: (1) zebrafish larvae display characteristic patterns of exploratory behaviours in the standard open field, such as thigmotaxis/centre avoidance; (2) environmental complexity (i.e. presence of colours) differentially affects patterns of exploratory behaviours and greatly attenuates natural zone preference; (3) larvae displayed the ability to discriminate colours. As reported previously in adult zebrafish, larvae showed avoidance towards blue and black; however, in contrast to the reported adult behaviour, larvae displayed avoidance towards red. Avoidance towards yellow and preference for green and orange are shown for the first time, (4) compared to standard open field tests, exposure to the colour-enriched open field resulted in an enhanced expression of anxiety-like behaviours. To conclude, we not only developed and adapted a traditional rodent behavioural assay that serves as a gold standard in preclinical drug screening, but we also provide a version of the same test that affords the possibility to investigate the impact of environmental stress on behaviour in larval zebrafish while representing the first test for assessment of natural colour preference/avoidance in larval zebrafish. In the future, these assays will improve preclinical drug screening methodologies towards the goal to uncover novel drugs. This article is part of a Special Issue entitled: insert SI title. Copyright © 2012 Elsevier B.V. All rights reserved.

Barriers to movement and spread of Radopholus similis in anthurium

USDA-ARS?s Scientific Manuscript database

Radopholus similis, the causal agent of anthurium decline, is challenging to manage in anthurium cut flower production. Management can include preplant soil fumigation and the planting of nematode-free anthurium into the field. However, nematodes reinfect the newly planted anthurium quickly through ...

Counseling in Greece

ERIC Educational Resources Information Center

Malikiosi-Loizos, Maria; Ivey, Allen E.

2012-01-01

There is rapid growth in Greece's professional and research activity in counseling, despite the lack of a clear professional identity for the field. It is hoped this will be overcome through the newly started graduate programs. Opportunities, objectives, and strategies for counseling's advancement should be directed toward close and essential…

Open Content in Open Context

ERIC Educational Resources Information Center

Kansa, Sarah Whitcher; Kansa, Eric C.

2007-01-01

This article presents the challenges and rewards of sharing research content through a discussion of Open Context, a new open access data publication system for field sciences and museum collections. Open Context is the first data repository of its kind, allowing self-publication of research data, community commentary through tagging, and clear…

Apparatus for efficient sidewall containment of molten metal with horizontal alternating magnetic fields utilizing a ferromagnetic dam

DOEpatents

Praeg, Walter F.

1997-01-01

An apparatus for casting sheets of metal from molten metal. The apparatus includes a containment structure having an open side, a horizontal alternating magnetic field generating structure and a ferromagnetic dam. The magnetic field and the ferromagnetic dam contain the molten metal from leaking out side portions of the open side of the containment structure.

Marine Corps Recruits: A Historical Look at Accessions and Bootcamp Performance

DTIC Science & Technology

2010-09-01

without the promise of an occupational field . Their code is PN, and these are called open contracts. In this slide, we graph the percentage of open ...means that occupational specialties such as infantry, armor, field artillery, and short-range air defense artillery are closed to women...enlistment contracts began for small numbers of Marines. While the 3 -, 4-, and 6-year initial enlistment contracts were open to the same group of MOSs

The Arctic Gakkel Vents (AGAVE) Expedition: Technology Development and the Search for Deep-Sea Hydrothermal Vent Fields Under the Arctic Ice Cap

NASA Astrophysics Data System (ADS)

Reves-Sohn, R. A.; Singh, H.; Humphris, S.; Shank, T.; Jakuba, M.; Kunz, C.; Murphy, C.; Willis, C.

2007-12-01

Deep-sea hydrothermal fields on the Gakkel Ridge beneath the Arctic ice cap provide perhaps the best terrestrial analogue for volcanically-hosted chemosynthetic biological communities that may exist beneath the ice-covered ocean of Europa. In both cases the key enabling technologies are robotic (untethered) vehicles that can swim freely under the ice and the supporting hardware and software. The development of robotic technology for deep- sea research beneath ice-covered oceans thus has relevance to both polar oceanography and future astrobiological missions to Europa. These considerations motivated a technology development effort under the auspices of NASA's ASTEP program and NSF's Office of Polar Programs that culminated in the AGAVE expedition aboard the icebreaker Oden from July 1 - August 10, 2007. The scientific objective was to study hydrothermal processes on the Gakkel Ridge, which is a key target for global studies of deep-sea vent fields. We developed two new autonomous underwater vehicles (AUVs) for the project, and deployed them to search for vent fields beneath the ice. We conducted eight AUV missions (four to completion) during the 40-day long expedition, which also included ship-based bathymetric surveys, CTD/rosette water column surveys, and wireline photographic and sampling surveys of remote sections of the Gakkel Ridge. The AUV missions, which lasted 16 hours on average and achieved operational depths of 4200 meters, returned sensor data that showed clear evidence of hydrothermal venting, but for a combination of technical reasons and time constraints, the AUVs did not ultimately return images of deep-sea vent fields. Nevertheless we used our wireline system to obtain images and samples of extensive microbial mats that covered fresh volcanic surfaces on a newly discovered set of volcanoes. The microbes appear to be living in regions where reducing and slightly warm fluids are seeping through cracks in the fresh volcanic terrain. These discoveries shed new light on the nature of volcanic and hydrothermal processes in the Arctic basin, and also demonstrate the importance of new technologies for advancing science beneath ice-covered oceans. Operationally, the AUV missions pushed the envelope of deep-sea technology. The recoveries were particularly difficult as it was necessary to have the vehicle find small pools of open water next to the ship, but in some cases the ice was in a state of regional compression such that no open water could be found or created. In these cases a well-calibrated, ship-based, short-baseline acoustic system was essential for successful vehicle recoveries. In all we were able to achieve a variety of operational and technological advances that provide stepping stones for future under-ice robotic missions, both on Earth and perhaps eventually on Europa.

Mice selectively bred for open-field thigmotaxis: life span and stability of the selection trait.

PubMed

Leppänen, Pia K; Ewalds-Kvist, S Béatrice M; Selander, Ritva-Kajsa

2005-04-01

In 2 experiments, the authors examined 69 mice selectively bred for high or low levels of open-field (OF) thigmotactic behavior (high open-field thigmotaxis [HOFT] and low open-field thigmotaxis [LOFT], respectively). They found that the strains differed in defecation during the 60-min exposure to the OF. Furthermore, the strains differed with regard to their life spans: The more thigmotactic HOFT mice lived longer than the LOFT mice. The strains were not differentiated by food intake or excretion. The strain difference in thigmotaxis was not age dependent, and it persisted in the home-cage condition as well. Neither the location (center or wall) of the starting point nor the shape (circular or square) of the OF arena affected the difference in wall-seeking behavior between the two strains. The authors concluded that the difference in thigmotaxis (or emotionality) between the HOFT and LOFT mice is a stable and robust feature of these animals.

Are voluntary wheel running and open-field behavior correlated in mice? Different answers from comparative and artificial selection approaches.

PubMed

Careau, Vincent; Bininda-Emonds, Olaf R P; Ordonez, Genesis; Garland, Theodore

2012-09-01

Voluntary wheel running and open-field behavior are probably the two most widely used measures of locomotion in laboratory rodents. We tested whether these two behaviors are correlated in mice using two approaches: the phylogenetic comparative method using inbred strains of mice and an ongoing artificial selection experiment on voluntary wheel running. After taking into account the measurement error and phylogenetic relationships among inbred strains, we obtained a significant positive correlation between distance run on wheels and distance moved in the open-field for both sexes. Thigmotaxis was negatively correlated with distance run on wheels in females but not in males. By contrast, mice from four replicate lines bred for high wheel running did not differ in either distance covered or thigmotaxis in the open field as compared with mice from four non-selected control lines. Overall, results obtained in the selection experiment were generally opposite to those observed among inbred strains. Possible reasons for this discrepancy are discussed.

Exposure to an open-field arena increases c-Fos expression in a distributed anxiety-related system projecting to the basolateral amygdaloid complex.

PubMed

Hale, M W; Hay-Schmidt, A; Mikkelsen, J D; Poulsen, B; Shekhar, A; Lowry, C A

2008-08-26

Anxiety states and anxiety-related behaviors appear to be regulated by a distributed and highly interconnected system of brain structures including the basolateral amygdala. Our previous studies demonstrate that exposure of rats to an open-field in high- and low-light conditions results in a marked increase in c-Fos expression in the anterior part of the basolateral amygdaloid nucleus (BLA) compared with controls. The neural mechanisms underlying the anatomically specific effects of open-field exposure on c-Fos expression in the BLA are not clear, however, it is likely that this reflects activation of specific afferent input to this region of the amygdala. In order to identify candidate brain regions mediating anxiety-induced activation of the basolateral amygdaloid complex in rats, we used cholera toxin B subunit (CTb) as a retrograde tracer to identify neurons with direct afferent projections to this region in combination with c-Fos immunostaining to identify cells responding to exposure to an open-field arena in low-light (8-13 lux) conditions (an anxiogenic stimulus in rats). Adult male Wistar rats received a unilateral microinjection of 4% CTb in phosphate-buffered saline into the basolateral amygdaloid complex. Rats were housed individually for 11 days after CTb injections and handled (HA) for 2 min each day. On the test day rats were either, 1) exposed to an open-field in low-light conditions (8-13 lux) for 15 min (OF); 2) briefly HA or 3) left undisturbed (control). We report that dual immunohistochemical staining for c-Fos and CTb revealed an increase in the percentage of c-Fos-immunopositive basolateral amygdaloid complex-projecting neurons in open-field-exposed rats compared with HA and control rats in the ipsilateral CA1 region of the ventral hippocampus, subiculum and lateral entorhinal cortex. These data are consistent with the hypothesis that exposure to the open-field arena activates an anxiety-related neuronal system with convergent input to the basolateral amygdaloid complex.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crijns, W; Vandenbroucke, D; Leblans, P

Purpose: Computed Radiography (CR) dosimetry could offer film dosimetry resolution and flexibility but with reusability and instantaneous processing. For an experimental CR-plate, designed for radiotherapy (Zeff=18), CR’s typical out-of-field over-response to low energy photons was previously reduced to 8%. The present work assesses the impact of the residual over-response when open-fields are combined or when intensity modulated fields are used. Methods: Agfa Healthcare’s experimental CRplate was scanned and erased 4min after each irradiation using a flying-spot CR-15-X-engine based reader, which was adapted for radiotherapy dosimetry. A CR-plate specific calibration and uniformity correction was used.For open-fields two abutting half beams (5×10cm{supmore » 2}) captured out-offield and in-field doses in a single image. Additionally, both half beams were measured individually as well as a 3×18Gy open-field SBRT-lung treatment. For intensity modulated fields standard test patterns (Chair and Pyramid) and a clinical 5×5Gy rectal VMAT plan were captured. All measurements were compared to the corresponding dose calculations. Results: For open-fields the out-of-field overdose was clearly larger than the in-field overdose (10% vs. 4%). The sum of the individual measurements corresponded well with the combined measurement (dose difference, ΔD<−2.2%). The SBRT case had no overdose in the high dose region; ΔD=−5.6%±3.3%, the deviation was attributed to CR-fading effects (−0.3%/min) which were not corrected for.Compared to open-fields, intensity modulated deliveries had a further increased over-response out-offield (ΔD=+58% to +125% [Chair] +43% [Pyramid]), due to the increased amount of low energy photons for IMRT. However, this effect was not measured in-field where even decreased dose signals were observed (ΔD=−0.3% to +2.25% [Chair], −4.5% to −0.1% [Pyramid]). The rectal VMAT treatment had a dose difference +2.4%±6.0%. The in-field deviations were attributed to a residual non-uniformity. Conclusion: The experimental CRplate’s out-of-field over-response does not propagate in in-field overresponse errors when static or dynamic (IMRT/VMAT) abutting fields are used.« less

Molecular dynamics simulations give insight into the conformational change, complex formation, and electron transfer pathway for cytochrome P450 reductase

PubMed Central

Sündermann, Axel; Oostenbrink, Chris

2013-01-01

Cytochrome P450 reductase (CYPOR) undergoes a large conformational change to allow for an electron transfer to a redox partner to take place. After an internal electron transfer over its cofactors, it opens up to facilitate the interaction and electron transfer with a cytochrome P450. The open conformation appears difficult to crystallize. Therefore, a model of a human CYPOR in the open conformation was constructed to be able to investigate the stability and conformational change of this protein by means of molecular dynamics simulations. Since the role of the protein is to provide electrons to a redox partner, the interactions with cytochrome P450 2D6 (2D6) were investigated and a possible complex structure is suggested. Additionally, electron pathway calculations with a newly written program were performed to investigate which amino acids relay the electrons from the FMN cofactor of CYPOR to the HEME of 2D6. Several possible interacting amino acids in the complex, as well as a possible electron transfer pathway were identified and open the way for further investigation by site directed mutagenesis studies. PMID:23832577

Sound Source Identification Through Flow Density Measurement and Correlation With Far Field Noise

NASA Technical Reports Server (NTRS)

Panda, J.; Seasholtz, R. G.

2001-01-01

Sound sources in the plumes of unheated round jets, in the Mach number range 0.6 to 1.8, were investigated experimentally using "casuality" approach, where air density fluctuations in the plumes were correlated with the far field noise. The air density was measured using a newly developed Molecular Rayleigh scattering based technique, which did not require any seeding. The reference at the end provides a detailed description of the measurement technique.

Establishment probability in newly founded populations.

PubMed

Gusset, Markus; Müller, Michael S; Grimm, Volker

2012-06-20

Establishment success in newly founded populations relies on reaching the established phase, which is defined by characteristic fluctuations of the population's state variables. Stochastic population models can be used to quantify the establishment probability of newly founded populations; however, so far no simple but robust method for doing so existed. To determine a critical initial number of individuals that need to be released to reach the established phase, we used a novel application of the "Wissel plot", where -ln(1 - P0(t)) is plotted against time t. This plot is based on the equation P(0)t=1-c(1)e(-ω(1t)), which relates the probability of extinction by time t, P(0)(t), to two constants: c(1) describes the probability of a newly founded population to reach the established phase, whereas ω(1) describes the population's probability of extinction per short time interval once established. For illustration, we applied the method to a previously developed stochastic population model of the endangered African wild dog (Lycaon pictus). A newly founded population reaches the established phase if the intercept of the (extrapolated) linear parts of the "Wissel plot" with the y-axis, which is -ln(c(1)), is negative. For wild dogs in our model, this is the case if a critical initial number of four packs, consisting of eight individuals each, are released. The method we present to quantify the establishment probability of newly founded populations is generic and inferences thus are transferable to other systems across the field of conservation biology. In contrast to other methods, our approach disaggregates the components of a population's viability by distinguishing establishment from persistence.

The Role of Memory Consolidation in Generalisation of New Linguistic Information

ERIC Educational Resources Information Center

Tamminen, Jakke; Davis, Matthew H.; Merkx, Marjolein; Rastle, Kathleen

2012-01-01

Accounts of memory that postulate complementary learning systems (CLS) have become increasingly influential in the field of language learning. These accounts predict that generalisation of newly learnt linguistic information to untrained contexts requires offline memory consolidation. Such generalisation should not be observed immediately after…

A Handheld Open-Field Infant Keratometer (An American Ophthalmological Society Thesis)

PubMed Central

Miller, Joseph M.

2010-01-01

Purpose: To design and evaluate a new infant keratometer that incorporates an unobstructed view of the infant with both eyes (open-field design). Methods: The design of the open-field infant keratometer is presented, and details of its construction are given. The design incorporates a single-ring keratoscope for measurement of corneal astigmatism over a 4-mm region of the cornea and includes a rectangular grid target concentric within the ring to allow for the study of higher-order aberrations of the eye. In order to calibrate the lens and imaging system, a novel telecentric test object was constructed and used. The system was bench calibrated against steel ball bearings of known dimensions and evaluated for accuracy while being used in handheld mode in a group of 16 adult cooperative subjects. It was then evaluated for testability in a group of 10 infants and toddlers. Results: Results indicate that while the device achieved the goal of creating an open-field instrument containing a single-ring keratoscope with a concentric grid array for the study of higher-order aberrations, additional work is required to establish better control of the vertex distance. Conclusion: The handheld open-field infant keratometer demonstrates testability suitable for the study of infant corneal astigmatism. Use of collimated light sources in future iterations of the design must be incorporated in order to achieve the accuracy required for clinical investigation. PMID:21212850

Potential risk levels of invasive Neoleucinodes elegantalis (small tomato borer) in areas optimal for open-field Solanum lycopersicum (tomato) cultivation in the present and under predicted climate change.

PubMed

da Silva, Ricardo Siqueira; Kumar, Lalit; Shabani, Farzin; Picanço, Marcelo Coutinho

2017-03-01

Neoleucinodes elegantalis is one of the major insect pests of Solanum lycopersicum. Currently, N. elegantalis is present only in America and the Caribbean, and is a threat in the world's largest S. lycopersicum-producing countries. In terms of potential impact on agriculture, the impact of climate change on insect invasions must be a concern. At present, no research exists regarding the effects of climatic change on the risk level of N. elegantalis. The purpose of this study was to develop a model for S. lycopersicum and N. elegantalis, utilizing CLIMEX to determine risk levels of N. elegantalis in open-field S. lycopersicum cultivation in the present and under projected climate change, using the global climate model CSIRO-Mk3.0. Large areas are projected to be suitable for N. elegantalis and optimal for open-field S. lycopersicum cultivation at the present time. However, in the future these areas will become unsuitable for both species. Conversely, other regions in the future may become optimal for open-field S. lycopersicum cultivation, with a varying risk level for N. elegantalis. The risk level results presented here provide a useful tool to design strategies to prevent the introduction and establishment of N. elegantalis in open-field S. lycopersicum cultivation. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

A handheld open-field infant keratometer (an american ophthalmological society thesis).

PubMed

Miller, Joseph M

2010-12-01

To design and evaluate a new infant keratometer that incorporates an unobstructed view of the infant with both eyes (open-field design). The design of the open-field infant keratometer is presented, and details of its construction are given. The design incorporates a single-ring keratoscope for measurement of corneal astigmatism over a 4-mm region of the cornea and includes a rectangular grid target concentric within the ring to allow for the study of higher-order aberrations of the eye. In order to calibrate the lens and imaging system, a novel telecentric test object was constructed and used. The system was bench calibrated against steel ball bearings of known dimensions and evaluated for accuracy while being used in handheld mode in a group of 16 adult cooperative subjects. It was then evaluated for testability in a group of 10 infants and toddlers. Results indicate that while the device achieved the goal of creating an open-field instrument containing a single-ring keratoscope with a concentric grid array for the study of higher-order aberrations, additional work is required to establish better control of the vertex distance. The handheld open-field infant keratometer demonstrates testability suitable for the study of infant corneal astigmatism. Use of collimated light sources in future iterations of the design must be incorporated in order to achieve the accuracy required for clinical investigation.

Effects of phenazepam on the behavior of C57BL/6 and BALB/c mice in the open field test after naloxone pretreatment.

PubMed

Seredenin, S B; Nadorova, A V; Kolik, L G; Yarkova, M A

2013-07-01

We studied the effects of phenazepam (0.075 mg/kg) after pretreatment (5 minutes before) with naloxone (10 mg/kg) on open-field behavior of C57Bl/6 and BALB/c mice. In ex vivo experiments, we studied the effects of naloxone (1 and 10 mg/kg) on receptor binding of [(3)H]-flunitrazepam by membranes of brain fraction (P1+P2) of C57Bl/6 and BALB/c mice. It was shown that naloxone increased motor activity in the open field in BALB/c mice and decreased this parameter in C57Bl/6 mice. During combined treatment, naloxone potentiated the activating effects of phenazepam on the open-field behavior of BALB/c mice and slightly increased the sedative effect of this drug in C57Bl/6 mice. Naloxone stimulated reception of [(3)H]-flunitrazepam in BALB/c mice and slightly increased radioligand binding in C57Bl/6 mice. These data attest to enhanced reception in benzodiazepine site of GABAA-receptor under conditions of opioid receptor blockade, the presence of anxiolytic or sedative (depending on the phenotype of the response to emotional stress) effect of naloxone, and co-directed effects of naloxone and benzodiazepine tranquilizer on open-field behavior of C57Bl/6 and BALB/c mice.

Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs.

PubMed

Siwak, C T; Gruet, P; Woehrlé, F; Muggenburg, B A; Murphey, H L; Milgram, N W

2000-11-01

To compare the efficacy of adrafinil, propentofylline, and nicergoline for enhancing behavior of aged dogs. 36 Beagles between 9 and 16 years old. Dogs were randomly assigned to receive adrafinil (20 mg/kg of body weight, PO, q 24 h; n = 12), propentofylline (5 mg/kg, PO, q 12 h; 12), or nicergoline (0.5 mg/kg, PO, q 24 h; 12) for 33 days. Baseline behaviors in an open field and in kennels (home cage) were recorded before treatment. After treatment, behaviors in the open field were recorded 2 hours after drug administration on days 2, 15, and 28, and 10 hours after administration on days 7, 20, and 33. Behaviors in the home cage were recorded 2 and 7 hours after drug administration on days 4, 17, and 30. Treatment with adrafinil resulted in a significant increase in locomotion in each of the open-field tests and an increase in locomotion in the home cage. This latter increase was smaller and more variable than that in the open field. Locomotion was not affected by treatment with propentofylline or nicergoline. In the open field, sniffing decreased over time in all 3 groups, but the largest decline was observed in the propentofylline group. Treatment with adrafinil may improve the quality of life of aged dogs by increasing exploratory behavior and alertness.

Opening mechanism of adenylate kinase can vary according to selected molecular dynamics force field

NASA Astrophysics Data System (ADS)

Unan, Hulya; Yildirim, Ahmet; Tekpinar, Mustafa

2015-07-01

Adenylate kinase is a widely used test case for many conformational transition studies. It performs a large conformational transition between closed and open conformations while performing its catalytic function. To understand conformational transition mechanism and impact of force field choice on E. Coli adenylate kinase, we performed all-atom explicit solvent classical molecular dynamics simulations starting from the closed conformation with four commonly used force fields, namely, Amber99, Charmm27, Gromos53a6, Opls-aa. We carried out 40 simulations, each one 200 ns. We analyzed completely 12 of them that show full conformational transition from the closed state to the open one. Our study shows that different force fields can have a bias toward different transition pathways. Transition time scales, frequency of conformational transitions, order of domain motions and free energy landscapes of each force field may also vary. In general, Amber99 and Charmm27 behave similarly while Gromos53a6 results have a resemblance to the Opls-aa force field results.

A Crisis in Competency: The Strategic and Ethical Imperative to Assessing New Graduate Nurses' Clinical Reasoning.

PubMed

Kavanagh, Joan M; Szweda, Christine

The aim of the study was to assess entry-level competency and practice readiness of newly graduated nurses. Literature on success of new graduates focuses primarily on National Council of State Boards of Nursing Licensure Examination (NCLEX-RN) pass rates, creating a false and incomplete picture of practice readiness. Posthire and prestart Performance-Based Development System assessments were administered to more than 5,000 newly graduated nurses at a large midwestern academic medical center between July 2010 and July 2015. Aggregate baseline data indicate that only 23 percent of newly graduated nurses demonstrate entry-level competencies and practice readiness. New data suggest that we are losing ground in the quest for entry-level competency. Graduates often are underprepared to operate in the complex field of professional practice where increased patient acuity and decreased length of stay, coupled with a lack of deep learning in our academic nursing programs, have exacerbated a crisis in competency.

Evaluating the Quality and Usability of Open Data for Public Health Research: A Systematic Review of Data Offerings on 3 Open Data Platforms.

PubMed

Martin, Erika G; Law, Jennie; Ran, Weijia; Helbig, Natalie; Birkhead, Guthrie S

Government datasets are newly available on open data platforms that are publicly accessible, available in nonproprietary formats, free of charge, and with unlimited use and distribution rights. They provide opportunities for health research, but their quality and usability are unknown. To describe available open health data, identify whether data are presented in a way that is aligned with best practices and usable for researchers, and examine differences across platforms. Two reviewers systematically reviewed a random sample of data offerings on NYC OpenData (New York City, all offerings, n = 37), Health Data NY (New York State, 25% sample, n = 71), and HealthData.gov (US Department of Health and Human Services, 5% sample, n = 75), using a standard coding guide. Three open health data platforms at the federal, New York State, and New York City levels. Data characteristics from the coding guide were aggregated into summary indices for intrinsic data quality, contextual data quality, adherence to the Dublin Core metadata standards, and the 5-star open data deployment scheme. One quarter of the offerings were structured datasets; other presentation styles included charts (14.7%), documents describing data (12.0%), maps (10.9%), and query tools (7.7%). Health Data NY had higher intrinsic data quality (P < .001), contextual data quality (P < .001), and Dublin Core metadata standards adherence (P < .001). All met basic "web availability" open data standards; fewer met higher standards of "hyperlinked to other data." Although all platforms need improvement, they already provide readily available data for health research. Sustained effort on improving open data websites and metadata is necessary for ensuring researchers use these data, thereby increasing their research value.

Education Scholars' Perceptions and Practices toward Open Access Publishing

ERIC Educational Resources Information Center

Ellingford, Lori Michelle

2012-01-01

Although open access publishing has been available since 1998, we know little regarding scholars' perceptions and practices toward publishing in open access outlets, especially in the social science community. Open access publishing has been slow to penetrate the field of education, yet the potential impact of open access could make this…

Method of determining interwell oil field fluid saturation distribution

DOEpatents

Donaldson, Erle C.; Sutterfield, F. Dexter

1981-01-01

A method of determining the oil and brine saturation distribution in an oil field by taking electrical current and potential measurements among a plurality of open-hole wells geometrically distributed throughout the oil field. Poisson's equation is utilized to develop fluid saturation distributions from the electrical current and potential measurement. Both signal generating equipment and chemical means are used to develop current flow among the several open-hole wells.

Apparatus for efficient sidewall containment of molten metal with horizontal alternating magnetic fields utilizing a ferromagnetic dam

DOEpatents

Praeg, W.F.

1997-02-11

An apparatus is disclosed for casting sheets of metal from molten metal. The apparatus includes a containment structure having an open side, a horizontal alternating magnetic field generating structure and a ferromagnetic dam. The magnetic field and the ferromagnetic dam contain the molten metal from leaking out side portions of the open side of the containment structure. 25 figs.

Measurements of store forces and moments and cavity pressures for a generic store in and near a box cavity at subsonic and transonic speeds

NASA Technical Reports Server (NTRS)

Stallings, Robert L., Jr.; Plentovich, E. B.; Tracy, M. B.; Hemsch, Michael J.

1995-01-01

An experimental force and moment study was conducted in the Langley 8-Foot Transonic Pressure Tunnel for a generic store in and near rectangular box cavities contained in a flat-plate configuration at subsonic and transonic speeds. Surface pressures were measured inside the cavities and on the flat plate. The length-to-height ratios were 5.42, 6.25, 10.83, and 12.50. The corresponding width-to-height ratios were 2.00, 2.00, 4.00, and 4.00. The free-stream Mach number range was from 0.20 to 0.95. Surface pressure measurements inside the cavities indicated that the flow fields for the shallow cavities were either closed or transitional near the transitional/closed boundary. For the deep cavities, the flow fields were either open or near the open/transitional boundary. The presence of the store did not change the type of flow field and had only small effects on the pressure distributions. For transitional or open transitional flow fields, increasing the free-stream Mach number resulted in large reductions in pitching-moment coefficient. Values of pitching-moment coefficient were always much greater for closed flow fields than for open flow fields.

Construction of orthogonal synchronized bi-directional field to enhance heating efficiency of magnetic nanoparticles.

PubMed

Chen, Shih-Wei; Lai, Jr-Jie; Chiang, Chen-Li; Chen, Cheng-Lung

2012-06-01

Magnetic hyperthermia using magnetic nanoparticles (MNPs) has attracted considerable attention as one of the promising tumor therapy. The study has been developed under single magnetic field. Recently, we found that the immobile MNP may generate more heat under two synchronous ac magnetic fields than traditional single and circular polarized fields based on model simulation result. According to this finding we constructed an orthogonal synchronized bi-directional field (OSB field). The system contained two LC resonant inverters (L: inductor, C: capacitor) and both vertical and transverse ac magnetic fields were generated by two Helmholtz coils. To reduce the interference, the axis directional of two coils were arranged orthogonally. The experiments showed that the heating ability of aggregated MNPs is greatly enhanced under this newly designed OSB field without increasing the strength of magnetic field. The OSB field system provides a promising way for future clinical hyperthermia.

Construction of orthogonal synchronized bi-directional field to enhance heating efficiency of magnetic nanoparticles

NASA Astrophysics Data System (ADS)

Chen, Shih-Wei; Lai-Jie, Jr.; Chiang, Chen-Li; Chen, Cheng-Lung

2012-06-01

Magnetic hyperthermia using magnetic nanoparticles (MNPs) has attracted considerable attention as one of the promising tumor therapy. The study has been developed under single magnetic field. Recently, we found that the immobile MNP may generate more heat under two synchronous ac magnetic fields than traditional single and circular polarized fields based on model simulation result. According to this finding we constructed an orthogonal synchronized bi-directional field (OSB field). The system contained two LC resonant inverters (L: inductor, C: capacitor) and both vertical and transverse ac magnetic fields were generated by two Helmholtz coils. To reduce the interference, the axis directional of two coils were arranged orthogonally. The experiments showed that the heating ability of aggregated MNPs is greatly enhanced under this newly designed OSB field without increasing the strength of magnetic field. The OSB field system provides a promising way for future clinical hyperthermia.

KENNEDY SPACE CENTER, FLA. - At the KSC Visitor Complex, actor and Master of Ceremonies Lance Henriksen (at podium) introduces four newly inducted Space Shuttle astronauts to the audience at their induction ceremony into the U.S. Astronaut Hall of Fame. From left center, they are Story Musgrave, Sally K. Ride, Daniel Brandenstein, and Robert "Hoot" Gibson. Also standing, left, is former astronaut James A. Lovell. Conceived by six of the Mercury Program astronauts, the U.S. Astronaut Hall of Fame opened in 1990 to provide a place where space travelers could be remembered for their participation and accomplishments in the U.S. space program. The four new inductees join 48 previously honored astronauts from the ranks of the Gemini, Apollo, Skylab, Apollo-Soyuz, and Space Shuttle programs.

NASA Image and Video Library

2003-06-21

KENNEDY SPACE CENTER, FLA. - At the KSC Visitor Complex, actor and Master of Ceremonies Lance Henriksen (at podium) introduces four newly inducted Space Shuttle astronauts to the audience at their induction ceremony into the U.S. Astronaut Hall of Fame. From left center, they are Story Musgrave, Sally K. Ride, Daniel Brandenstein, and Robert "Hoot" Gibson. Also standing, left, is former astronaut James A. Lovell. Conceived by six of the Mercury Program astronauts, the U.S. Astronaut Hall of Fame opened in 1990 to provide a place where space travelers could be remembered for their participation and accomplishments in the U.S. space program. The four new inductees join 48 previously honored astronauts from the ranks of the Gemini, Apollo, Skylab, Apollo-Soyuz, and Space Shuttle programs.

MSiReader v1.0: Evolving Open-Source Mass Spectrometry Imaging Software for Targeted and Untargeted Analyses.

PubMed

Bokhart, Mark T; Nazari, Milad; Garrard, Kenneth P; Muddiman, David C

2018-01-01

A major update to the mass spectrometry imaging (MSI) software MSiReader is presented, offering a multitude of newly added features critical to MSI analyses. MSiReader is a free, open-source, and vendor-neutral software written in the MATLAB platform and is capable of analyzing most common MSI data formats. A standalone version of the software, which does not require a MATLAB license, is also distributed. The newly incorporated data analysis features expand the utility of MSiReader beyond simple visualization of molecular distributions. The MSiQuantification tool allows researchers to calculate absolute concentrations from quantification MSI experiments exclusively through MSiReader software, significantly reducing data analysis time. An image overlay feature allows the incorporation of complementary imaging modalities to be displayed with the MSI data. A polarity filter has also been incorporated into the data loading step, allowing the facile analysis of polarity switching experiments without the need for data parsing prior to loading the data file into MSiReader. A quality assurance feature to generate a mass measurement accuracy (MMA) heatmap for an analyte of interest has also been added to allow for the investigation of MMA across the imaging experiment. Most importantly, as new features have been added performance has not degraded, in fact it has been dramatically improved. These new tools and the improvements to the performance in MSiReader v1.0 enable the MSI community to evaluate their data in greater depth and in less time. Graphical Abstract ᅟ.

An Autosampler and Field Sample Carrier for Maximizing Throughput Using an Open-Air, Surface Sampling Ion Source for MS

EPA Science Inventory

A recently developed, commercially available, open-air, surface sampling ion source for mass spectrometers provides individual analyses in several seconds. To realize its full throughput potential, an autosampler and field sample carrier were designed and built. The autosampler ...

Grafting Technique to Eliminate Rootstock Suckering of Grafted Tomatoes

USDA-ARS?s Scientific Manuscript database

Vegetable grafting has been proposed as a technique for avoiding disease problems in tomatoes in open field production. In this study we investigated the current use of grafting in an open field scenario and found a serious problem with the grafting techniques. In the Fall of 2007, commercially pr...

Development of Activity Level in Children

ERIC Educational Resources Information Center

Routh, Donald K.; And Others

1974-01-01

The open-field activity of 140 children 3-9 years old was observed. Children were either told to stay in one part of the room and play or were given free play instructions. Findings showed that open-field activity decreased with age; parents' activity ratings were also lower for older children. (CS)

Tuberculosis beliefs among recent Vietnamese refugees in New York State.

PubMed Central

Carey, J W; Oxtoby, M J; Nguyen, L P; Huynh, V; Morgan, M; Jeffery, M

1997-01-01

OBJECTIVE: To identify newly arrived Vietnamese refugees' beliefs about tuberculosis (TB) and TB education needs. METHODS: In 1994, the New York State Health Department and the Centers for Disease Control and Prevention conducted a survey of 51 newly arrived adult Vietnamese refugees in two New York counties. After being trained in interview methods, two bilingual researchers asked 32 open-ended questions on the causes of TB, TB treatment, and the disease's impact on work and social relationships. RESULTS: Respondents correctly viewed TB as an infectious lung disease with symptoms such as cough, weakness, and weight loss. Hard manual labor, smoking, alcohol consumption, and poor nutrition were believed to be risk factors. Many respondents incorrectly believed that asymptomatic latent infection is not possible and that infection inevitably leads to disease. Nearly all respondents anticipated that having tuberculosis would adversely impact their work, family, and community activities and relationships. CONCLUSIONS: Targeted patient education is needed to address misconceptions about TB among Vietnamese refugees and to help ensure adherence to prescribed treatment regimens. PMID:9018292

Brief Report: Sexual Risk Behaviors of HIV Seroconverters in the US Army, 2012-2014.

PubMed

Hakre, Shilpa; Scoville, Stephanie L; Pacha, Laura A; Peel, Sheila A; Kim, Jerome H; Michael, Nelson L; Cersovsky, Steven B; Scott, Paul T

2015-12-01

The United States (US) Army implemented a comprehensive HIV characterization program in 2012 following repeal of the Don't Ask, Don't Tell policy banning openly homosexual individuals from serving in the US military. Program staff administered a standardized case report form to soldiers newly diagnosed with HIV from 2012 to 2014 in compliance with new program requirements. The case report form documented sociodemographic, sexual, and other risk behavior information elicited from US Army regulation-mandated epidemiologic interviews at initial HIV notification. A majority of HIV-infected soldiers were male and of black/African American racial origin. In the HIV risk period, male soldiers commonly reported male-male sexual contact, civilian partners, online partner-seeking, unprotected anal sex, and expressed surprise at having a positive HIV result. Don't Ask, Don't Tell repeal allows for risk screening and reduction interventions targeting a newly identifiable risk category in the US Army. At-risk populations need to be identified and assessed for possible unmet health needs.

Brief Report: Sexual Risk Behaviors of HIV Seroconverters in the US Army, 2012–2014

PubMed Central

Scoville, Stephanie L.; Pacha, Laura A.; Peel, Sheila A.; Kim, Jerome H.; Michael, Nelson L.; Cersovsky, Steven B.; Scott, Paul T.

2015-01-01

Abstract: The United States (US) Army implemented a comprehensive HIV characterization program in 2012 following repeal of the Don't Ask, Don't Tell policy banning openly homosexual individuals from serving in the US military. Program staff administered a standardized case report form to soldiers newly diagnosed with HIV from 2012 to 2014 in compliance with new program requirements. The case report form documented sociodemographic, sexual, and other risk behavior information elicited from US Army regulation-mandated epidemiologic interviews at initial HIV notification. A majority of HIV-infected soldiers were male and of black/African American racial origin. In the HIV risk period, male soldiers commonly reported male–male sexual contact, civilian partners, online partner-seeking, unprotected anal sex, and expressed surprise at having a positive HIV result. Don't Ask, Don't Tell repeal allows for risk screening and reduction interventions targeting a newly identifiable risk category in the US Army. At-risk populations need to be identified and assessed for possible unmet health needs. PMID:26247893

Real-time GPS integration for prototype earthquake early warning and near-field imaging of the earthquake rupture process

NASA Astrophysics Data System (ADS)

Hudnut, K. W.; Given, D.; King, N. E.; Lisowski, M.; Langbein, J. O.; Murray-Moraleda, J. R.; Gomberg, J. S.

2011-12-01

Over the past several years, USGS has developed the infrastructure for integrating real-time GPS with seismic data in order to improve our ability to respond to earthquakes and volcanic activity. As part of this effort, we have tested real-time GPS processing software components , and identified the most robust and scalable options. Simultaneously, additional near-field monitoring stations have been built using a new station design that combines dual-frequency GPS with high quality strong-motion sensors and dataloggers. Several existing stations have been upgraded in this way, using USGS Multi-Hazards Demonstration Project and American Recovery and Reinvestment Act funds in southern California. In particular, existing seismic stations have been augmented by the addition of GPS and vice versa. The focus of new instrumentation as well as datalogger and telemetry upgrades to date has been along the southern San Andreas fault in hopes of 1) capturing a large and potentially damaging rupture in progress and augmenting inputs to earthquake early warning systems, and 2) recovering high quality recordings on scale of large dynamic displacement waveforms, static displacements and immediate and long-term post-seismic transient deformation. Obtaining definitive records of large ground motions close to a large San Andreas or Cascadia rupture (or volcanic activity) would be a fundamentally important contribution to understanding near-source large ground motions and the physics of earthquakes, including the rupture process and friction associated with crack propagation and healing. Soon, telemetry upgrades will be completed in Cascadia and throughout the Plate Boundary Observatory as well. By collaborating with other groups on open-source automation system development, we will be ready to process the newly available real-time GPS data streams and to fold these data in with existing strong-motion and other seismic data. Data from these same stations will also serve the very practical purpose of enabling earthquake early warning and greatly improving rapid finite-fault source modeling. Multiple uses of the effectively very broad-band data obtained by these stations, for operational and research purposes, are bound to occur especially because all data will be freely, openly and instantly available.

Sloshing of a bubbly magma reservoir as a mechanism of triggered eruptions

NASA Astrophysics Data System (ADS)

Namiki, Atsuko; Rivalta, Eleonora; Woith, Heiko; Walter, Thomas R.

2016-06-01

Large earthquakes sometimes activate volcanoes both in the near field as well as in the far field. One possible explanation is that shaking may increase the mobility of the volcanic gases stored in magma reservoirs and conduits. Here experimentally and theoretically we investigate how sloshing, the oscillatory motion of fluids contained in a shaking tank, may affect the presence and stability of bubbles and foams, with important implications for magma conduits and reservoirs. We adopt this concept from engineering: severe earthquakes are known to induce sloshing and damage petroleum tanks. Sloshing occurs in a partially filled tank or a fully filled tank with density-stratified fluids. These conditions are met at open summit conduits or at sealed magma reservoirs where a bubbly magma layer overlays a newly injected denser magma layer. We conducted sloshing experiments by shaking a rectangular tank partially filled with liquids, bubbly fluids (foams) and fully filled with density-stratified fluids; i.e., a foam layer overlying a liquid layer. In experiments with foams, we find that foam collapse occurs for oscillations near the resonance frequency of the fluid layer. Low viscosity and large bubble size favor foam collapse during sloshing. In the layered case, the collapsed foam mixes with the underlying liquid layer. Based on scaling considerations, we constrain the conditions for the occurrence of foam collapse in natural magma reservoirs. We find that seismic waves with lower frequencies < 1 Hz, usually excited by large earthquakes, can resonate with magma reservoirs whose width is > 0.5 m. Strong ground motion > 0.1 m s- 1 can excite sloshing with sufficient amplitude to collapse a magma foam in an open conduit or a foam overlying basaltic magma in a closed magma reservoir. The gas released from the collapsed foam may infiltrate the rock or diffuse through pores, enhancing heat transfer, or may generate a gas slug to cause a magmatic eruption. The overturn in the magma reservoir provides new nucleation sites which may help to prepare a following/delayed eruption. Mt. Fuji erupted 49 days after the large Hoei earthquake (1707) both dacitic and basaltic magmas. The eruption might have been triggered by magma mixing through sloshing.

A user-friendly tool to transform large scale administrative data into wide table format using a MapReduce program with a Pig Latin based script.

PubMed

Horiguchi, Hiromasa; Yasunaga, Hideo; Hashimoto, Hideki; Ohe, Kazuhiko

2012-12-22

Secondary use of large scale administrative data is increasingly popular in health services and clinical research, where a user-friendly tool for data management is in great demand. MapReduce technology such as Hadoop is a promising tool for this purpose, though its use has been limited by the lack of user-friendly functions for transforming large scale data into wide table format, where each subject is represented by one row, for use in health services and clinical research. Since the original specification of Pig provides very few functions for column field management, we have developed a novel system called GroupFilterFormat to handle the definition of field and data content based on a Pig Latin script. We have also developed, as an open-source project, several user-defined functions to transform the table format using GroupFilterFormat and to deal with processing that considers date conditions. Having prepared dummy discharge summary data for 2.3 million inpatients and medical activity log data for 950 million events, we used the Elastic Compute Cloud environment provided by Amazon Inc. to execute processing speed and scaling benchmarks. In the speed benchmark test, the response time was significantly reduced and a linear relationship was observed between the quantity of data and processing time in both a small and a very large dataset. The scaling benchmark test showed clear scalability. In our system, doubling the number of nodes resulted in a 47% decrease in processing time. Our newly developed system is widely accessible as an open resource. This system is very simple and easy to use for researchers who are accustomed to using declarative command syntax for commercial statistical software and Structured Query Language. Although our system needs further sophistication to allow more flexibility in scripts and to improve efficiency in data processing, it shows promise in facilitating the application of MapReduce technology to efficient data processing with large scale administrative data in health services and clinical research.

Fuel cell assembly unit for promoting fluid service and electrical conductivity

DOEpatents

Jones, Daniel O.

1999-01-01

Fluid service and/or electrical conductivity for a fuel cell assembly is promoted. Open-faced flow channel(s) are formed in a flow field plate face, and extend in the flow field plate face between entry and exit fluid manifolds. A resilient gas diffusion layer is located between the flow field plate face and a membrane electrode assembly, fluidly serviced with the open-faced flow channel(s). The resilient gas diffusion layer is restrained against entering the open-faced flow channel(s) under a compressive force applied to the fuel cell assembly. In particular, a first side of a support member abuts the flow field plate face, and a second side of the support member abuts the resilient gas diffusion layer. The support member is formed with a plurality of openings extending between the first and second sides of the support member. In addition, a clamping pressure is maintained for an interface between the resilient gas diffusion layer and a portion of the membrane electrode assembly. Preferably, the support member is spikeless and/or substantially flat. Further, the support member is formed with an electrical path for conducting current between the resilient gas diffusion layer and position(s) on the flow field plate face.

Towards comprehensive syntactic and semantic annotations of the clinical narrative

PubMed Central

Albright, Daniel; Lanfranchi, Arrick; Fredriksen, Anwen; Styler, William F; Warner, Colin; Hwang, Jena D; Choi, Jinho D; Dligach, Dmitriy; Nielsen, Rodney D; Martin, James; Ward, Wayne; Palmer, Martha; Savova, Guergana K

2013-01-01

Objective To create annotated clinical narratives with layers of syntactic and semantic labels to facilitate advances in clinical natural language processing (NLP). To develop NLP algorithms and open source components. Methods Manual annotation of a clinical narrative corpus of 127 606 tokens following the Treebank schema for syntactic information, PropBank schema for predicate-argument structures, and the Unified Medical Language System (UMLS) schema for semantic information. NLP components were developed. Results The final corpus consists of 13 091 sentences containing 1772 distinct predicate lemmas. Of the 766 newly created PropBank frames, 74 are verbs. There are 28 539 named entity (NE) annotations spread over 15 UMLS semantic groups, one UMLS semantic type, and the Person semantic category. The most frequent annotations belong to the UMLS semantic groups of Procedures (15.71%), Disorders (14.74%), Concepts and Ideas (15.10%), Anatomy (12.80%), Chemicals and Drugs (7.49%), and the UMLS semantic type of Sign or Symptom (12.46%). Inter-annotator agreement results: Treebank (0.926), PropBank (0.891–0.931), NE (0.697–0.750). The part-of-speech tagger, constituency parser, dependency parser, and semantic role labeler are built from the corpus and released open source. A significant limitation uncovered by this project is the need for the NLP community to develop a widely agreed-upon schema for the annotation of clinical concepts and their relations. Conclusions This project takes a foundational step towards bringing the field of clinical NLP up to par with NLP in the general domain. The corpus creation and NLP components provide a resource for research and application development that would have been previously impossible. PMID:23355458

Hospital or general practice? Results of two experiments limiting the number of self referrals of patients with injuries to hospitals in The Netherlands.

PubMed Central

Sixma, H J; de Bakker, D H

1996-01-01

OBJECTIVE: To describe the results of two Dutch experiments aimed at limiting the number of self referrals to accident and emergency (A&E) departments of a newly opened hospital. METHODS: Basic design for both field experiments was a one group test-retest study, with the opening of a new hospital being the experimental factor. Data refer (1) to the number of patient contacts for acute somatic and non-somatic professional help with traumata and intoxications filled in on contact registration forms, and (2) to patient reports based on written questionnaires and interviews by telephone. RESULTS: Both studies show that it is possible to limit the number of self referrals, although it is important to be aware of possible side effects. The solution chosen in one of the cities, with patients visiting the A&E department being sent back to a general practitioner, was highly effective but resulted in a series of complaints from the public. This forced the authorities to abandon their original policy. The model chosen in the other city, with two specialized health centres serving as an alternative for the free A&E department of the new hospital, was somewhat less successful in preventing patients from going directly to a hospital, but was much more acceptable for the public. CONCLUSIONS: Both studies showed that controlling the number of self referrals to the A&E departments of hospitals is possible. However, the more rigid the model, the more difficult it will be to have this model accepted by patients. Based on arguments like cost-effectiveness, a better solution might be not to discourage people from going to the hospital with minor injuries, but to integrate primary health care (PHC) and hospital facilities. PMID:8832346

Sun-to-Earth simulations of geo-effective Coronal Mass Ejections with EUHFORIA: a heliospheric-magnetospheric model chain approach

NASA Astrophysics Data System (ADS)

Scolini, C.; Verbeke, C.; Gopalswamy, N.; Wijsen, N.; Poedts, S.; Mierla, M.; Rodriguez, L.; Pomoell, J.; Cramer, W. D.; Raeder, J.

2017-12-01

Coronal Mass Ejections (CMEs) and their interplanetary counterparts are considered to be the major space weather drivers. An accurate modelling of their onset and propagation up to 1 AU represents a key issue for more reliable space weather forecasts, and predictions about their actual geo-effectiveness can only be performed by coupling global heliospheric models to 3D models describing the terrestrial environment, e.g. magnetospheric and ionospheric codes in the first place. In this work we perform a Sun-to-Earth comprehensive analysis of the July 12, 2012 CME with the aim of testing the space weather predictive capabilities of the newly developed EUHFORIA heliospheric model integrated with the Gibson-Low (GL) flux rope model. In order to achieve this goal, we make use of a model chain approach by using EUHFORIA outputs at Earth as input parameters for the OpenGGCM magnetospheric model. We first reconstruct the CME kinematic parameters by means of single- and multi- spacecraft reconstruction methods based on coronagraphic and heliospheric CME observations. The magnetic field-related parameters of the flux rope are estimated based on imaging observations of the photospheric and low coronal source regions of the eruption. We then simulate the event with EUHFORIA, testing the effect of the different CME kinematic input parameters on simulation results at L1. We compare simulation outputs with in-situ measurements of the Interplanetary CME and we use them as input for the OpenGGCM model, so to investigate the magnetospheric response to solar perturbations. From simulation outputs we extract some global geomagnetic activity indexes and compare them with actual data records and with results obtained by the use of empirical relations. Finally, we discuss the forecasting capabilities of such kind of approach and its future improvements.

Stretching of Hot Lithosphe: A Significant Mode of Crustal Stretching in Southeast Asia

NASA Astrophysics Data System (ADS)

de Montserrat Navarro, A.; Morgan, J. P.; Hall, R.; White, L. T.

2017-12-01

SE Asia roughly covers roughly 15% of the Earth's surface and represents one of the most tectonically active regions in the world, yet its tectonic evolution remains relatively poorly studied and constrained in comparison with other regions. Recent episodes of extension have been associated with sedimentary basin growth and phases of crustal melting, uplift and extremely rapid exhumation of young (<7Ma) metamorphic core complexes. This is recorded by seismic imagery of basins offshore Sulawesi and New Guinea as well as through new field studies of the onshore geology in these regions. A growing body of new geochronological and biostratigraphic data provides some control on the rates of processes. We use two-dimensional numerical models to investigate the evolution of the distinctive extensional basins in SE Asia. Our models suggest that, at the onset of stretching, the lithosphere was considerably hotter than in more typically studied rift settings (e.g. Atlantic opening, East African Rift, Australia-Antarctica opening). High Moho temperatures are key in shaping the architecture of the stretched lithosphere: A) hot and week lower crust fails to transmit the stress and brittle deformation, thus resulting in a strong decoupling between crust and lithospheric mantle; B) the mode of deformation is dominated by the ductile flow and boudinage of lower crust, yielding the exhumation of one-to-several partially molten lower crustal bodies, including metamorphic core complexes; C) continental break-up is often inhibited by the ductile behaviour of the crust, and it is only achieved after considerable cooling of the lithosphere. To better constrain the extension rates in which these basins formed, we compare P-T and cooling paths of lower crustal material in a suite of models with newly available data from the Palu and Malino metamorphic core complexes in Sulawesi, Indonesia.

Expedition One CDR Shepherd with IMAX camera

NASA Image and Video Library

2001-02-11

STS98-E-5164 (11 February 2001) --- Astronaut William M. (Bill) Shepherd documents activity onboard the newly attached Destiny laboratory using an IMAX motion picture camera. The crews of Atlantis and the International Space Station on February 11 opened the Destiny laboratory and spent the first full day of what are planned to be years of work ahead inside the orbiting science and command center. Shepherd opened the Destiny hatch, and he and Shuttle commander Kenneth D. Cockrell ventured inside at 8:38 a.m. (CST). Members of both crews went to work quickly inside the new module, activating air systems, fire extinguishers, alarm systems, computers and internal communications. The crew also continued equipment transfers from the shuttle to the station and filmed several scenes onboard the station using an IMAX camera. This scene was recorded with a digital still camera.

Aerial photo shows Launch Complex 39 Area

NASA Technical Reports Server (NTRS)

2000-01-01

This aerial photo shows the areas recently opened as part of KSC's Safe Haven project. The curved road in the center is the newly restored crawlerway leading around the Vehicle Assembly Building (VAB) and Orbiter Processing Facility 3 (OPF-3) into the VAB high bay 2 (open on the lower right), where a mobile launcher platform/crawler-transporter currently sits. The Safe Haven project will enable the storage of orbiters during severe weather. OPF1 and OPF-2 are at the lower right. The crawlerway also extends from the east side of the VAB out to the two launch pads. Launch Pad 39A is visible to the left of the crawlerway. In the distance is the Atlantic Ocean. To the right of the VAB is the turn basin, into which ships tow the barge for offloading new external tanks from Louisiana.

MAJOR ELECTRON EVENTS AND CORONAL MAGNETIC CONFIGURATIONS OF THE RELATED SOLAR ACTIVE REGIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, C.; Owen, C. J.; Matthews, S. A.

A statistical survey of 26 major electron events during the period 2002 February through the end of solar cycle 23 is presented. We have obtained electron solar onset times and the peak flux spectra for each event by fitting to a power-law spectrum truncated by an exponential high-energy tail, i.e., f(E){approx}E{sup -{delta}}e{sup -E/E{sub 0}}. We also derived the coronal magnetic configurations of the related solar active regions (ARs) from the potential-field source-surface model. It is found that (1) 10 of the 11 well-connected open field-line events are prompt events whose solar onset times coincide with the maxima of flare emissionmore » and 13 of the 14 closed field-line events are delayed events. (2) A not-well-connected open field-line event and one of the closed field-line events are prompt events, they are both associated with large-scale coronal disturbances or dimming. (3) An averaged harder spectrum is found in open field-line events compared with the closed ones. Specifically, the averaged spectral index {delta} is of 1.6 {+-} 0.3 in open field-line events and of 2.0 {+-} 0.4 in closed ones. The spectra of three closed field-line events show infinite rollover energies E {sub 0}. These correlations clearly establish a significant link between the coronal magnetic field-line topology and the escape of charged particles from the flaring ARs into interplanetary space during the major solar energetic particle events.« less

An empirical examination of the factor structure of compassion.

PubMed

Gu, Jenny; Cavanagh, Kate; Baer, Ruth; Strauss, Clara

2017-01-01

Compassion has long been regarded as a core part of our humanity by contemplative traditions, and in recent years, it has received growing research interest. Following a recent review of existing conceptualisations, compassion has been defined as consisting of the following five elements: 1) recognising suffering, 2) understanding the universality of suffering in human experience, 3) feeling moved by the person suffering and emotionally connecting with their distress, 4) tolerating uncomfortable feelings aroused (e.g., fear, distress) so that we remain open to and accepting of the person suffering, and 5) acting or being motivated to act to alleviate suffering. As a prerequisite to developing a high quality compassion measure and furthering research in this field, the current study empirically investigated the factor structure of the five-element definition using a combination of existing and newly generated self-report items. This study consisted of three stages: a systematic consultation with experts to review items from existing self-report measures of compassion and generate additional items (Stage 1), exploratory factor analysis of items gathered from Stage 1 to identify the underlying structure of compassion (Stage 2), and confirmatory factor analysis to validate the identified factor structure (Stage 3). Findings showed preliminary empirical support for a five-factor structure of compassion consistent with the five-element definition. However, findings indicated that the 'tolerating' factor may be problematic and not a core aspect of compassion. This possibility requires further empirical testing. Limitations with items from included measures lead us to recommend against using these items collectively to assess compassion. Instead, we call for the development of a new self-report measure of compassion, using the five-element definition to guide item generation. We recommend including newly generated 'tolerating' items in the initial item pool, to determine whether or not factor-level issues are resolved once item-level issues are addressed.

Efficacious insect and disease control with laser-guided air-assisted sprayer

USDA-ARS?s Scientific Manuscript database

Efficacy of a newly developed air-assisted variable-rate sprayer was investigated for the control of arthropod pests and plant diseases in six commercial fields. The sprayer was integrated with a high-speed laser scanning sensor, a custom-designed signal processing program, an automatic flow control...

The fruit flies (Tephritidae) of Ontario

USDA-ARS?s Scientific Manuscript database

Thirteen species of Tephritidae are newly recorded from Ontario, and alternative format keys are provided to the 31 genera and 72 species of fruit fly now known from, or likely to occur, in the province. Standard dichotomous keys to genera, and simplified field keys to genera and species are provide...

Applied oceanography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bishop, J.M.

This book combines oceanography principles and applications such as marine pollution, resources, and transportation. It is divided into two main parts treating the basic principles of physical oceanography, and presenting a unique systems framework showing how physical oceanography, marine ecology, economics, and government policy may be combined to define the newly developing field of applied oceanography.

Combining fuzzy set theory and nonlinear stretching enhancement for unsupervised classification of cotton root rot

USDA-ARS?s Scientific Manuscript database

Cotton root rot is a destructive disease affecting cotton production. Accurate identification of infected areas within fields is useful for cost-effective control of the disease. The uncertainties caused by various infection stages and newly infected plants make it difficult to achieve accurate clas...

Characterization of an Aggregation Pheromone in Hylesinus pruinosus (Coleoptera: Curculionidae: Scolytinae)

Treesearch

William Shepherd; Brian Sullivan; Bradley Hoosier; JoAnne Barrett; Tessa Bauman

2010-01-01

We conducted laboratory and field bioassays to characterize the pheromone system of an ash bark beetle, Hylesinus pruinosus Eichhoff (Coleoptera: Curculionidae: Scolytinae). Solitary females in newly initiated galleries in ash logs produced (+)-exo-brevicomin, whereas male beetles paired with females produced (+)-endo-brevicomin, lesser quantities of...

Small Business Training: A Guide for Program Building.

ERIC Educational Resources Information Center

Jellison, Holly M., Ed.

Offering information for staff orientations at institutions launching new small business training programs, for newly assigned Small Business Administration (SBA) field personnel, and for annual program reviews and revisions, this guide explains how to organize and deliver quality small business training in a cost-effective manner. Section 1…

Racer (40% ammonium nonanoate) broadcast application for broadleaf weed control in spring-transplanted onions

USDA-ARS?s Scientific Manuscript database

Racer (40% ammonium nonanoate) is a newly approved herbicide for organically grown food crops. Ammonium nonanoate occurs in nature and is primarily formed from biodegradation of higher fatty acids. Field research was conducted in southeast Oklahoma (Atoka County, Lane, OK) to determine the effect ...

Changes in host-seeking behavior of Puerto Rican Aedes aegypti (L.) after colonization

USDA-ARS?s Scientific Manuscript database

The effects of colonization on host-seeking behavior of mosquitoes was examined by comparing attraction responses of newly colonized Aedes aegypti (L.) from field-collected eggs in Puerto Rico to that of the Gainesville (Florida) strain, originally from Orlando (Florida) and in colony since 1952. Fe...

Late blight-resistant tuber-bearing Solanum species in field and laboratory trials

USDA-ARS?s Scientific Manuscript database

Late blight, caused by Phytophthora infestans, is the most disastrous and widespread disease of potato. One of the most effective means of controlling late blight is through the use of resistant cultivars, but newly developed resistant cultivars often lose their resistance after a few years of comm...

Introduction on Internet Research, Theory, and Practice: Perspectives from Ireland

ERIC Educational Resources Information Center

Fowley, Cathy; English, Claire; Thouësny, Sylvie

2013-01-01

In September 2000, the newly-formed Association of Internet Researchers (AoIR) held its first international conference, entitled "the State of the Interdiscipline", highlighting a new locus of research, and a "focus on the Internet as a distinct interdisciplinary field for research" (http://aoir.org/…