Sample records for ng-150 opredelenie belka

  1. Once daily maraviroc 300 mg or 150 mg in combination with ritonavir-boosted darunavir 800/100 mg.

    PubMed

    Okoli, Chinyere; Siccardi, Marco; Thomas-William, Sathish; Dufty, Ngozi; Khonyongwa, Kirstin; Ainsworth, Jonathan; Watson, John; Cook, Roseanne; Gandhi, Kate; Hickinbottom, Geraldine; Owen, Andrew; Taylor, Stephen

    2012-03-01

    To describe the pharmacokinetics of maraviroc when dosed at 150 or 300 mg once daily with 800/100 mg of darunavir/ritonavir. A retrospective case-note review of HIV-infected adults taking maraviroc was conducted. Patients on a maraviroc-based regimen for a minimum of 5 weeks were grouped as receiving: (i) 300 mg of maraviroc twice daily with 245 mg of tenofovir/200 mg of emtricitabine; (ii) 300 mg of maraviroc once daily with 800/100 mg of darunavir/ritonavir once daily; and (iii) 150 mg of maraviroc once daily with 800/100 mg of darunavir/ritonavir once daily. C(trough) and C(peak) data were collected at 2, 12 or 24 h post-dose. Sixty-six patients were included, providing 115 samples. The median (IQR) C(peak) was 378 (350-640) ng/mL for 300 mg of maraviroc twice daily with 245 mg of tenofovir/200 mg of emtricitabine (n=9), 728 (378-935) ng/mL for 300 mg of maraviroc once daily with darunavir/ritonavir (n=29) and 364 (104-624) ng/mL for 150 mg of maraviroc once daily with darunavir/ritonavir (n=2; P=0.24). The median (IQR) C(trough) was 46 (33-61) ng/mL for 300 mg of maraviroc twice daily with 245 mg of tenofovir/200 mg of emtricitabine (n=12), 70 (49-97) ng/mL for 300 mg of maraviroc once daily with darunavir/ritonavir (n=34) and 43 (35-55) ng/mL for 150 mg of maraviroc once daily with darunavir/ritonavir (n=17; P=0.001). The maraviroc C(trough) in black patients (n=34) was 61 (45-110) ng/mL and in white patients (n=29) it was 49 (42-70) ng/mL (P=0.04). The C(peak) in black patients (n=20) was 800 (397-1060) ng/mL versus 387 (336-723) ng/mL in white patients (n=20; P=0.02). Once daily coadministration of 300 mg of maraviroc with 800/100 mg of darunavir/ritonavir was well tolerated and had favourable pharmacokinetics when compared with 300 mg of maraviroc twice daily with 245 mg of tenofovir/200 mg of emtricitabine. A 24% higher C(trough) and 107% higher C(peak) was seen in black patients compared with white patients.

  2. The NG2 Protein Is Not Required for Glutamatergic Neuron-NG2 Cell Synaptic Signaling.

    PubMed

    Passlick, Stefan; Trotter, Jacqueline; Seifert, Gerald; Steinhäuser, Christian; Jabs, Ronald

    2016-01-01

    NG2 glial cells (as from now NG2 cells) are unique in receiving synaptic input from neurons. However, the components regulating formation and maintenance of these neuron-glia synapses remain elusive. The transmembrane protein NG2 has been considered a potential mediator of synapse formation and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) clustering, because it contains 2 extracellular Laminin G/Neurexin/Sex Hormone-Binding Globulin domains, which in neurons are crucial for formation of transsynaptic neuroligin-neurexin complexes. NG2 is connected via Glutamate Receptor-Interacting Protein with GluA2/3-containing AMPARs, thereby possibly mediating receptor clustering in glial postsynaptic density. To elucidate the role of NG2 in neuron-glia communication, we investigated glutamatergic synaptic transmission in juvenile and aged hippocampal NG2 cells of heterozygous and homozygous NG2 knockout mice. Neuron-NG2 cell synapses readily formed in the absence of NG2. Short-term plasticity, synaptic connectivity, postsynaptic AMPAR current kinetics, and density were not affected by NG2 deletion. During development, an NG2-independent acceleration of AMPAR current kinetics and decreased synaptic connectivity were observed. Our results indicate that the lack of NG2 does not interfere with genesis and basic properties of neuron-glia synapses. In addition, we demonstrate frequent expression of neuroligins 1-3 in juvenile and aged NG2 cells, suggesting a role of these molecules in synapse formation between NG2 glia and neurons. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  3. PVT-NG sensor final report.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mitchell, Dean James; Brusseau, Charles A.

    2012-01-01

    This document is a final report for the polyvinyl toluene (PVT) neutron-gamma (PVT-NG) project, which was sponsored by the Domestic Nuclear Detection Office (DNDO). The PVT-NG sensor uses PVT detectors for both gamma and neutron detection. The sensor exhibits excellent spectral resolution and gain stabilization, which are features that are beneficial for detection of both gamma-ray and neutron sources. In fact, the ability to perform isotope identification based on spectra that were measured by the PVT-NG sensor was demonstrated. As described in a previous report, the neutron sensitivity of the first version of the prototype was about 25% less thanmore » the DNDO requirement of 2.5 cps/ng for bare Cf-252. This document describes design modifications that were expected to improve the neutron sensitivity by about 50% relative to the PVT-NG prototype. However, the project was terminated before execution of the design modifications after portal vendors demonstrated other technologies that enable neutron detection without the use of He-3. Nevertheless, the PVT-NG sensor development demonstrated several performance goals that may be useful in future portal designs.« less

  4. Văn phòng Công nhận Chất lượng (BoA)

    Science.gov Websites

    »©c năng nhiệm vụ Ban lãnh đạo Công khai tài chính Dá»± toán Tình hình thá»±c hiện dá  nh thạo Giới thiệu về PT Các tổ chức cung cấp dịch vụ PT Liên hệ Ngôn ngá nhận Tổ chức giám định Đăng ký **Hướng dẫn nộp đơn đăng ký online Tin đào táº

  5. Noble Gas-Uranium Coordination and Intersystem Crossing for the CUO(Ne)x(Ng)n (Ng = Ar, Kr, Xe) Complexes in Solid Neon

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Andrews, Lester; Liang, Binyong; Li, Jun

    2004-02-15

    Atomic uranium excited by laser ablation reacts with CO in excess neon to produce the novel CUO molecule, which forms weak complexes CUO(Ne)m with neon and stronger complexes CUO(Ne)x(Ng)n (Ng = Ar, Kr, Xe) when the heavier noble gas atoms are present. The heavier CUO(Ne)m-1(Ng) complexes are identified through the effects of CO isotopic and Ng substitution on the neon matrix infrared spectra and by comparison to DFT frequency calculations on model complexes CUO(Ng) (Ng = Ne, Ar, Kr, Xe). The U-C and U-O stretching frequencies of CUO(Ne)m-1(Ng) complexes are slightly red shifted from 1047 and 872 cm-1 frequencies formore » the 1Sigma+ CUO ground state neon complex, which identifies singlet ground state CUO(Ne)m-1(Ng) complexes in solid neon. The next singlet CUO(Ne)x(Ng)2 complexes in excess neon follow in like manner. However, stretching modes and the isotopic shifts of the higher CUO(Ne)x(Ng)n complex approach those of the pure argon matrix CUO(Ar)n complex, which characterizes triple t ground state complexes by comparison to DFT frequency calculations.« less

  6. TCVN | CỔNG THÔNG TIN ĐIỆN TỬ TỔNG CỤC TIÊU CHUẨN ĐO

    Science.gov Websites

    ‘ạo Hệ thống Chi cục TCĐLCL Danh bạ điện thoại Tin tức Tin tổng hợp Tin tức ¡ Danh mục TCVN/QCVN Đo lường Hệ thống văn bản QPPL (Đo lường) Văn bản kỹ thuật Ä ‘o lường Việt nam - ĐLVN Thống kê quản lý đo lường Công bố biện pháp phòng ngá

  7. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Exceptions to the compatibility chart. 150.150 Section 150.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (G-MSO...

  8. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Exceptions to the compatibility chart. 150.150 Section 150.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (G-MSO...

  9. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Exceptions to the compatibility chart. 150.150 Section 150.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (CG-ENG-5...

  10. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Exceptions to the compatibility chart. 150.150 Section 150.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (CG-ENG-5...

  11. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Exceptions to the compatibility chart. 150.150 Section 150.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (CG-ENG-5...

  12. Characterization of Novel Simian Immunodeficiency Viruses from Red-Capped Mangabeys from Nigeria (SIVrcmNG409 and -NG411)

    PubMed Central

    Beer, Brigitte E.; Foley, Brian T.; Kuiken, Carla L.; Tooze, Zena; Goeken, Robert M.; Brown, Charles R.; Hu, Jinjie; Claire, Marisa St.; Korber, Bette T.; Hirsch, Vanessa M.

    2001-01-01

    Two novel simian immunodeficiency virus (SIV) strains from wild-caught red-capped mangabeys (Cercocebus torquatus torquatus) from Nigeria were characterized. Sequence analysis of the fully sequenced SIV strain rcmNG411 (SIVrcmNG411) and gag and pol sequence of SIVrcmNG409 revealed that they were genetically most closely related to the recently characterized SIVrcm from Gabon (SIVrcmGB1). Thus, red-capped mangabeys from distant geographic locations harbor a common lineage of SIV. SIVrcmNG411 carried a vpx gene in addition to vpr, suggesting a common evolutionary ancestor with SIVsm (from sooty mangabeys). However, SIVrcm was only marginally closer to SIVsm in that region than to any of the other lentiviruses. SIVrcm showed the highest similarity in pol with SIVdrl, isolated from a drill, a primate that is phylogenetically distinct from mangabey monkeys, and clustered with other primate lentiviruses (primarily SIVcpz [from chimpanzees] and SIVagmSab [from African green monkeys]) discordantly in different regions of the genome, suggesting a history of recombination. Despite the genetic relationship to SIVcpz in the pol gene, SIVrcmNG411 did not replicate in chimpanzee peripheral blood mononuclear cells (PBMC), although two other viruses unrelated to SIVcpz, SIVmndGB1 (from mandrills) and SIVlhoest (from L'Hoest monkeys), were able to grow in chimpanzee PBMC. The CCR5 24-bp deletion previously described in red-capped mangabeys from Gabon was also observed in Nigerian red-capped mangabeys, and SIVrcmNG411, like SIVrcmGB1, used CCR2B and STRL33 as coreceptors for virus entry. SIVrcm, SIVsm, SIVmndGB1, and all four SIVlhoest isolates but not SIVsun (from sun-tailed monkeys) replicated efficiently in human PBMC, suggesting that the ability to infect the human host can vary within one lineage. PMID:11711592

  13. NG9-1-1 transition issues report.

    DOT National Transportation Integrated Search

    2008-02-01

    A key outcome of the U.S. Department of Transportation (USDOT) Next Generation 9-1-1 : (NG9-1-1) Initiative is the identification of well-supported options and crucial transition issues : for migrating from todays 9-1-1 system to a NG9-1-1 system ...

  14. Functional roles of CSPG4/NG2 in chondrosarcoma.

    PubMed

    Jamil, Nuor S M; Azfer, Asim; Worrell, Harrison; Salter, Donald M

    2016-04-01

    CSPG4/NG2 is a multifunctional transmembrane protein with limited distribution in adult tissues including articular cartilage. The purpose of this study was to investigate the possible roles of CSPG4/NG2 in chondrosarcomas and to establish whether this molecule may have potential for targeted therapy. Stable knock-down of CSPG4/NG2 in the JJ012 chondrosarcoma cell line by shRNA resulted in decreased cell proliferation and migration as well as a decrease in gene expression of the MMP (matrix metalloproteinase) 3 protease and ADAMTS4 (aggrecanase). Chondrosarcoma cells in which CSPG4/NG2 was knocked down were more sensitive to doxorubicin than wild-type cells. The results indicate that CSPG4/NG2 has roles in regulating chondrosarcoma cell function in relation to growth, spread and resistance to chemotherapy and that anti-CSPG4/NG2 therapies may have potential in the treatment of surgically unresectable chondrosarcoma. © 2016 The Authors. International Journal of Experimental Pathology © 2016 International Journal of Experimental Pathology.

  15. Ovarian response to 150 µg corifollitropin alfa in a GnRH-antagonist multiple-dose protocol: a prospective cohort study.

    PubMed

    Lerman, Tamara; Depenbusch, Marion; Schultze-Mosgau, Askan; von Otte, Soeren; Scheinhardt, Markus; Koenig, Inke; Kamischke, Axel; Macek, Milan; Schwennicke, Arne; Segerer, Sabine; Griesinger, Georg

    2017-05-01

    The incidence of low (<6 oocytes) and high (>18 oocytes) ovarian response to 150 µg corifollitropin alfa in relation to anti-Müllerian hormone (AMH) and other biomarkers was studied in a multi-centre (n = 5), multi-national, prospective, investigator-initiated, observational cohort study. Infertile women (n = 212), body weight >60 kg, underwent controlled ovarian stimulation in a gonadotrophin-releasing hormone-antagonist multiple-dose protocol. Demographic, sonographic and endocrine parameters were prospectively assessed on cycle day 2 or 3 of a spontaneous menstruation before the administration of 150 µg corifollitropin alfa. Serum AMH showed the best correlation with the number of oocytes obtained among all predictor variables. In receiver-operating characteristic analysis, AMH at a threshold of 0.91 ng/ml showed a sensitivity of 82.4%, specificity of 82.4%, positive predictive value 52.9%and negative predictive value 95.1% for predicting low response (area under the curve [AUC], 95% CI; P-value: 0.853, 0.769-0.936; <0.0001). For predicting high response, the optimal threshold for AMH was 2.58 ng/ml, relating to a sensitivity of 80.0%, specificity 82.1%, positive predictive value 42.5% and negative predictive value 96.1% (AUC, 95% CI; P-value: 0.871, 0.787-0.955; <0.0001). In conclusion, patients with serum AMH concentrations between approximately 0.9 and 2.6 ng/ml were unlikely to show extremes of response. Copyright © 2017. Published by Elsevier Ltd.

  16. NgBR is essential for endothelial cell glycosylation and vascular development.

    PubMed

    Park, Eon Joo; Grabińska, Kariona A; Guan, Ziqiang; Sessa, William C

    2016-02-01

    NgBR is a transmembrane protein identified as a Nogo-B-interacting protein and recently has been shown to be a subunit required for cis-prenyltransferase (cisPTase) activity. To investigate the integrated role of NgBR in vascular development, we have characterized endothelial-specific NgBR knockout embryos. Here, we show that endothelial-specific NgBR knockout results in embryonic lethality due to vascular development defects in yolk sac and embryo proper. Loss of NgBR in endothelial cells reduces proliferation and promotes apoptosis of the cells largely through defects in the glycosylation of key endothelial proteins including VEGFR2, VE-cadherin, and CD31, and defective glycosylation can be rescued by treatment with the end product of cisPTase activity, dolichol phosphate. Moreover, NgBR functions in endothelial cells during embryogenesis are Nogo-B independent. These data uniquely show the importance of NgBR and protein glycosylation during vascular development. © 2016 The Authors.

  17. 76 FR 12627 - Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG Airplanes AGENCY: Federal Aviation Administration (FAA... on Diamond aeroplanes, the majority of which were DA 40. In additional, at least 18 doors have been... conditions) while the aeroplane was parked. All DA 40 and DA 42 aeroplanes have a system installed that...

  18. NgR1: A Tunable Sensor Regulating Memory Formation, Synaptic, and Dendritic Plasticity.

    PubMed

    Karlsson, Tobias E; Smedfors, Gabriella; Brodin, Alvin T S; Åberg, Elin; Mattsson, Anna; Högbeck, Isabelle; Wellfelt, Katrin; Josephson, Anna; Brené, Stefan; Olson, Lars

    2016-04-01

    Nogo receptor 1 (NgR1) is expressed in forebrain neurons and mediates nerve growth inhibition in response to Nogo and other ligands. Neuronal activity downregulates NgR1 and the inability to downregulate NgR1 impairs long-term memory. We investigated behavior in a serial behavioral paradigm in mice that overexpress or lack NgR1, finding impaired locomotor behavior and recognition memory in mice lacking NgR1 and impaired sequential spatial learning in NgR1 overexpressing mice. We also investigated a role for NgR1 in drug-mediated sensitization and found that repeated cocaine exposure caused stronger locomotor responses but limited development of stereotypies in NgR1 overexpressing mice. This suggests that NgR1-regulated synaptic plasticity is needed to develop stereotypies. Ex vivo magnetic resonance imaging and diffusion tensor imaging analyses of NgR1 overexpressing brains did not reveal any major alterations. NgR1 overexpression resulted in significantly reduced density of mature spines and dendritic complexity. NgR1 overexpression also altered cocaine-induced effects on spine plasticity. Our results show that NgR1 is a negative regulator of both structural synaptic plasticity and dendritic complexity in a brain region-specific manner, and highlight anterior cingulate cortex as a key area for memory-related plasticity. © The Author 2016. Published by Oxford University Press.

  19. NgR1: A Tunable Sensor Regulating Memory Formation, Synaptic, and Dendritic Plasticity

    PubMed Central

    Karlsson, Tobias E.; Smedfors, Gabriella; Brodin, Alvin T. S.; Åberg, Elin; Mattsson, Anna; Högbeck, Isabelle; Wellfelt, Katrin; Josephson, Anna; Brené, Stefan; Olson, Lars

    2016-01-01

    Nogo receptor 1 (NgR1) is expressed in forebrain neurons and mediates nerve growth inhibition in response to Nogo and other ligands. Neuronal activity downregulates NgR1 and the inability to downregulate NgR1 impairs long-term memory. We investigated behavior in a serial behavioral paradigm in mice that overexpress or lack NgR1, finding impaired locomotor behavior and recognition memory in mice lacking NgR1 and impaired sequential spatial learning in NgR1 overexpressing mice. We also investigated a role for NgR1 in drug-mediated sensitization and found that repeated cocaine exposure caused stronger locomotor responses but limited development of stereotypies in NgR1 overexpressing mice. This suggests that NgR1-regulated synaptic plasticity is needed to develop stereotypies. Ex vivo magnetic resonance imaging and diffusion tensor imaging analyses of NgR1 overexpressing brains did not reveal any major alterations. NgR1 overexpression resulted in significantly reduced density of mature spines and dendritic complexity. NgR1 overexpression also altered cocaine-induced effects on spine plasticity. Our results show that NgR1 is a negative regulator of both structural synaptic plasticity and dendritic complexity in a brain region-specific manner, and highlight anterior cingulate cortex as a key area for memory-related plasticity. PMID:26838771

  20. Cost efficient PMMA/NG nanocomposites for electromagnetic interference shielding applications

    NASA Astrophysics Data System (ADS)

    Yadav, Prachi; Rattan, Sunita; Tripathi, Ambuj; Kumar, Sandeep

    2017-06-01

    Cost-efficient polymethylmethacrylate/exfoliated nanographite (PMMA/NG) nanocomposites were prepared through the melt blending technique. The crystalline size of NG in nanocomposites was estimated using Scherrer’s formula and was found to be in the range of 42.4-50.6 nm. Scanning electron micrographs showed the homogeneous dispersion of NG in the PMMA matrix. The thermal degradation temperature (T d) of nanocomposites was found to rise monotonically with increase in the loading of NG. Differential scanning calorimetry measurement showed a significant improvement in glass transition temperature (T g) from 97.2 °C for neat PMMA to 106.4 °C for 4.0 wt% PMMA/NG nanocomposites. DC electrical conductivity measurement revealed that the prepared nanocomposites exhibited a low percolation threshold of 0.45 vol%. The s-parameters (S 11 and S 21) were measured through vector network analyser and were explored in the estimation of electromagnetic interference (EMI) shielding effectiveness (SE). The EMI SE of 19.2 dB (~ 99% attenuation of incoming microwave (MW) power) was attained in the 4.0 wt% PMMA/NG nanocomposite at 12.7 GHz MW frequency. Moreover, the observed broadband EMI SE spectra indicate that the prepared nanocomposites can be employed in lightweight and low-cost commercial EMI shielding applications.

  1. NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.

    PubMed

    Nakano, Masayuki; Tamura, Yasuhisa; Yamato, Masanori; Kume, Satoshi; Eguchi, Asami; Takata, Kumi; Watanabe, Yasuyoshi; Kataoka, Yosky

    2017-02-14

    NG2-expressing neural progenitor cells (i.e., NG2 glial cells) maintain their proliferative and migratory activities even in the adult mammalian central nervous system (CNS) and produce myelinating oligodendrocytes and astrocytes. Although NG2 glial cells have been observed in close proximity to neuronal cell bodies in order to receive synaptic inputs, substantive non-proliferative roles of NG2 glial cells in the adult CNS remain unclear. In the present study, we generated NG2-HSVtk transgenic rats and selectively ablated NG2 glial cells in the adult CNS. Ablation of NG2 glial cells produced defects in hippocampal neurons due to excessive neuroinflammation via activation of the interleukin-1 beta (IL-1β) pro-inflammatory pathway, resulting in hippocampal atrophy. Furthermore, we revealed that the loss of NG2 glial cell-derived hepatocyte growth factor (HGF) exacerbated these abnormalities. Our findings suggest that NG2 glial cells maintain neuronal function and survival via the control of neuroimmunological function.

  2. AtNG1 encodes a protein that is required for seed germination.

    PubMed

    Yang, Libo; Peng, Xiongbo; Sun, Meng-xiang

    2011-10-01

    The pentatricopeptide repeat (PPR) family of eukaryotic proteins has numerous members in plants and is important for plant development. In the present study, we cloned a novel PPR gene, designated AtNG1, and characterized the ng1 Arabidopsis mutant. Morphological and structural observation of an ng1 mutant revealed that its sexual reproduction and seed formation processes are essentially normal. The mature embryonic root of ng1 is fully developed and has a well-differentiated structure; however, ng1 seeds cannot germinate, even when supplied with supplemental hormones and nutrition. Further investigation showed that embryo expansion and root cell elongation fails to occur after water imbibitions. Transient gene expression analysis indicated that AtNG1 localizes in mitochondrion. This implies that the deficiency of mitochondrion function might be the reason for the failed seed germination. Thus, our finding confirmed that AtNG1 plays a critical role in the early process of seed germination. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  3. 77 FR 29694 - Richard H. NG, D.O.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-19] Richard H. NG, D.O....100(b), I order that DEA Certificate of Registration AN1255733, issued to Richard H. Ng, D.O., be, and it hereby is, revoked. I further order that any pending application of Richard H. Ng, D.O., to renew...

  4. The Path from VLITE to ngLOBO: A Roadmap for Evolving a Low Frequency Commensal System from the JVLA to the ngVLA

    NASA Astrophysics Data System (ADS)

    Kassim, Namir E.; Clarke, Tracy; Giacintucci, Simona; Helmboldt, Joseph; Ray, Paul S.; Peters, Wendy; Polisensky, Emil; hicks, Brian C.; Brisken, Walter; hyman, Scott D.; Deneva, Julia; Kerr, Matthew T.; Taylor, Gregory; Dowell, Jayce; Schinzel, Frank K.

    2018-01-01

    The VLA Low-band Ionosphere and Transient Experiment (VLITE, ) is a commensal observing system on the NRAO Karl G. Jansky Very Large Array (VLA). The separate optical path of the prime-focus sub-GHz dipole feeds and the Cassegrain-focus GHz feeds provided an opportunity to expand the simultaneous frequency operation of the VLA through joint observations across both systems. 16 VLA antennas are outfitted with dedicated samplers and use spare fibers to transport the 320-384 MHz band to the VLITE CPU-based correlator. Initial goals included exploring the scientific potential of a commensal low frequency system for ionospheric remote sensing, astrophysics and transients. VLITE operates at nearly 70% wall time with roughly 6200 hours of VLA time recorded each year.Several papers at this meeting review VLITE science and early results. Here we consider how the project could evolve in the future. Over the next 10 years, a straightforward evolutionary path calls for an expansion of VLITE to all 27 VLA antennas and to the maximum available low band receiver bandwidth (224-480 MHz). The GPU-based correlator for this LOw Band Observatory (LOBO) would also incorporate lower frequency signals from the new VLA 74 MHz system, including from VLA dishes (60-80 MHz) and standalone Long Wavelength Array (LWA) aperture array stations (20-80 MHz).In the longer term, we look towards leveraging the vast infrastructure of the ngVLA to include a commensal low frequency capability, called ngLOBO. As described in our community white paper (Taylor et al. 2018; arXiv:1708.00090), ngLOBO has three primary scientific missions: (1) Radio Large Synoptic Survey Telescope (Radio-LSST): one naturally wide beam, commensal with ngVLA, will conduct a continuous synoptic survey of large swaths of the sky for both slow and fast transients; (2) This same commensal beam will provide complementary low frequency images of all ngVLA targets when such data enhances their value. (3

  5. The Search for Cosmic Company: SETI on ngVLA

    NASA Astrophysics Data System (ADS)

    Croft, Steve; Siemion, Andrew; Hellbourg, Greg

    2018-01-01

    "Are we alone?" is one of the most profound human questions. The unprecedented capabilities of next generation radio telescopes, including ngVLA, will allow us to probe hitherto unexplored regions of parameter space, placing meaningful limits on the prevalence of technological civilizations in the Universe, or perhaps making one of the most significant discoveries in the history of science.Through both targeted and commensal observations, ngVLA data will be searched for signatures of technology (including narrow-band, Doppler-drifting, and more complex signals) that can be localized to particular positions on the sky. ngVLA provides critical capabilities in the 10 – 100 GHz range, a region of the spectrum used by many human technologies, to survey the sky at sensitivities unmatched by other facilities.

  6. SomethiNG 2 talk about-Transcriptional regulation in embryonic and adult oligodendrocyte precursors.

    PubMed

    Küspert, Melanie; Wegner, Michael

    2016-05-01

    Glial cells that express the chondroitin sulfate proteoglycan NG2 represent an inherently heterogeneous population. These so-called NG2-glia are present during development and in the adult CNS, where they are referred to as embryonic oligodendrocyte precursors and adult NG2-glia, respectively. They give rise to myelinating oligodendrocytes at all times of life. Over the years much has been learnt about the transcriptional network in embryonic oligodendrocyte precursors, and several transcription factors from the HLH, HMG-domain, zinc finger and homeodomain protein families have been identified as main constituents. Much less is known about the corresponding network in adult NG2-glia. Here we summarize and discuss current knowledge on functions of each of these transcription factor families in NG2-glia, and where possible compare transcriptional regulation in embryonic oligodendrocyte precursors and adult NG2-glia. This article is part of a Special Issue entitled SI:NG2-glia (Invited only). Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Next Generation Trusted Radiation Identification System (NG-TRIS).

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Flynn, Adam J.; Amai, Wendy A.; Merkle, Peter Benedict

    2010-05-01

    The original Trusted Radiation Identification System (TRIS) was developed from 1999-2001, featuring information barrier technology to collect gamma radiation template measurements useful for arms control regime operations. The first TRIS design relied upon a multichannel analyzer (MCA) that was external to the protected volume of the system enclosure, undesirable from a system security perspective. An internal complex programmable logic device (CPLD) contained data which was not subject to software authentication. Physical authentication of the TRIS instrument case was performed by a sensitive but slow eddy-current inspection method. This paper describes progress to date for the Next Generation TRIS (NG-TRIS), whichmore » improves the TRIS design. We have incorporated the MCA internal to the trusted system volume, achieved full authentication of CPLD data, and have devised rapid methods to authenticate the system enclosure and weld seals of the NG-TRIS enclosure. For a complete discussion of the TRIS system and components upon which NG-TRIS is based, the reader is directed to the comprehensive user's manual and system reference of Seager, et al.« less

  8. NG2 glia are required for vessel network formation during embryonic development

    PubMed Central

    Minocha, Shilpi; Valloton, Delphine; Brunet, Isabelle; Eichmann, Anne

    2015-01-01

    The NG2+ glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2+ glia originate from the Nkx2.1+ progenitors of the ventral telencephalon. Our analysis unravels that, beginning from E12.5 until E16.5, the NG2+ glia populate the entire dorsal telencephalon. Interestingly, their appearance temporally coincides with the establishment of blood vessel network in the embryonic brain. NG2+ glia are closely apposed to developing cerebral vessels by being either positioned at the sprouting tip cells or tethered along the vessel walls. Absence of NG2+ glia drastically affects the vascular development leading to severe reduction of ramifications and connections by E18.5. By revealing a novel and fundamental role for NG2+ glia, our study brings new perspectives to mechanisms underlying proper vessels network formation in embryonic brains. DOI: http://dx.doi.org/10.7554/eLife.09102.001 PMID:26651999

  9. Human Transcription Factor hTAFII150 (CIF150) Is Involved in Transcriptional Regulation of Cell Cycle Progression

    PubMed Central

    Martin, Jay; Halenbeck, Robert; Kaufmann, Jörg

    1999-01-01

    Here we present evidence that CIF150 (hTAFII150), the human homolog of Drosophila TAFII150, plays an important and selective role in establishing gene expression patterns necessary for progression through the cell cycle. Gel filtration experiments demonstrate that CIF150 (hTAFII150) seems to be less tightly associated with human transcription factor IID than hTAFII130 is associated with hTAFII250. The transient functional knockout of CIF150 (hTAFII150) protein led to cell cycle arrest at the G2/M transition in mammalian cell lines. PCR display analysis with the RNA derived from CIF150-depleted cells indicated that CIF150 (hTAFII150) is required for the transcription of only a subset of RNA polymerase II genes. CIF150 (hTAFII150) directly stimulated cyclin B1 and cyclin A transcription in cotransfection assays and in vitro assays, suggesting that the expression of these genes is dependent on CIF150 (hTAFII150) function. We defined a CIF150 (hTAFII150) consensus binding site and demonstrated that a CIF150-responsive cis element is present in the cyclin B1 core promoter. These results suggest that one function of CIF150 (hTAFII150) is to select specific RNA polymerase II core promoter elements involved in cell cycle progression. PMID:10409744

  10. On the Noble-Gas Induced Intersystem Crossing for the CUO Molecule: Experimental and Theoretical investigations of CUO(Ng)n (Ng = Ar, Kr, Xe; n = 1, 2, 3, 4) Complexes in Solid Neon

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liang, Binyong; Andrews, Lester S.; Li, Jun

    2004-02-09

    Uranium atoms excited by laser ablation react with CO in excess neon to produce the novel CUO molecule, which forms distinct Ng complexes (Ng = Ar, Kr, Xe) when the heavier noble gases are added. The CUO(Ng) complexes are identified through CO isotopic and Ng substitution on the neon matrix infrared spectra and by comparison to DFT frequency calculations. The U-C and U-O stretching frequencies of CUO(Ng) complexes are slightly red shifted from frequencies for the 1S+ CUO ground state, which identifies singlet ground state CUO(Ng) complexes. In solid neon the CUO molecule is also a complex CUO(Ne)n, and themore » CUO(Ne)n-1(Ng) complexes are likewise specified. The next singlet CUO(Ne)x(Ng)2 complexes in excess neon follow in like manner. However, the higher CUO(Ne)x(Ng)n complex (n = 3, 4) stretching modes approach pure argon matrix CUO(Ar)n values and isotopic behavior, which are characterized as triplet ground state complexes by DFT frequency calculations. This work suggests that the singlet-triplet crossing occurs with 3 Ar, 3 Kr or 4 Xe and a balance of Ne atoms coordinated to CUO in the neon matrix host.« less

  11. Antimüllerian hormone as a predictor of good-quality supernumerary blastocyst cryopreservation among women with levels <1 ng/mL versus 1-4 ng/mL.

    PubMed

    Kavoussi, Shahryar K; Odenwald, Kate C; Boehnlein, Lynn M; Summers-Colquitt, Roxanne B; Pool, Thomas B; Swain, Jason E; Jones, Jeffrey M; Lindstrom, Mary J; Lebovic, Dan I

    2015-09-01

    To determine whether antimüllerian hormone (AMH) levels predict the availability of good-quality supernumerary blastocysts for cryopreservation. Retrospective study. Two fertility centers. First fresh IVF cycles (n = 247) grouped as follows: 40 women <35 year old with AMH <1 ng/mL and 77 women with AMH 1-4 ng/mL; 62 women ≥35 year old with AMH <1 ng/mL, and 68 women with AMH 1-4 ng/mL. AMH level measured before IVF with ovarian stimulation protocols based on patient age and AMH level, including short gonadotropin-releasing hormone (GnRH) agonist, GnRH antagonist, or GnRH agonist microdose flare; supernumerary good-quality blastocysts cryopreserved on days 5 or 6 after retrieval. Supernumerary good-quality blastocysts for cryopreservation in relation to AMH levels. Among women <35 years of age, there was a statistically significant difference in the number of patients with supernumerary good-quality blastocysts for cryopreservation between the groups with AMH <1 ng/mL and AMH 1-4 ng/mL (30.0% vs. 58.4%) when adjusted for age. Among women ≥35 years of age, there was a statistically significant difference in the number of patients with supernumerary good-quality blastocyst cryopreservation between groups with AMH <1 ng/mL and AMH 1-4 ng/mL (16.1% vs. 42.6%), when adjusted for age. Low AMH levels are associated with a statistically significantly lower likelihood of blastocysts for cryopreservation as compared with higher AMH levels. This effect was seen among women both <35 and ≥35 years of age. Patient counseling should include realistic expectations for the probability of good-quality supernumerary blastocysts available for cryopreservation. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  12. The role of the NG2 proteoglycan in OPC and CNS network function.

    PubMed

    Sakry, Dominik; Trotter, Jacqueline

    2016-05-01

    In the normal mammalian CNS, the NG2 proteoglycan is expressed by oligodendrocyte precursor cells (OPC) but not by any other neural cell-type. NG2 is a type-1 membrane protein, exerting multiple roles in the CNS including intracellular signaling within the OPC, with effects on migration, cytoskeleton interaction and target gene regulation. It has been recently shown that the extracellular region of NG2, in addition to an adhesive function, acts as a soluble ECM component with the capacity to alter defined neuronal network properties. This region of NG2 is thus endowed with neuromodulatory properties. In order to generate biologically active fragments yielding these properties, the sequential cleavage of the NG2 protein by α- and γ-secretases occurs. The basal level of constitutive cleavage is stimulated by neuronal network activity. This processing leads to 4 major NG2 fragments which all have been associated with distinct biological functions. Here we summarize these functions, focusing on recent discoveries and their implications for the CNS. This article is part of a Special Issue entitled SI:NG2-glia(Invited only). Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Thrombospondin-4 Promotes Neuronal Differentiation of NG2 Cells via the ERK/MAPK Pathway.

    PubMed

    Yang, Hai Jie; Ma, Shuang Ping; Ju, Fei; Zhang, Ya Ping; Li, Zhi Chao; Zhang, Bin Bin; Lian, Jun Jiang; Wang, Lei; Cheng, Bin Feng; Wang, Mian; Feng, Zhi Wei

    2016-12-01

    NG2-expressing neural progenitors can produce neurons in the central nervous system, providing a potential cell resource of therapy for neurological disorders. However, the mechanism underlying neuronal differentiation of NG2 cells remains largely unknown. In this report, we found that a thrombospondin (TSP) family member, TSP4, is involved in the neuronal differentiation of NG2 cells. When TSP4 was overexpressed, NG2 cells underwent spontaneous neuronal differentiation, as demonstrated by the induction of various neuronal differentiation markers such as NeuN, Tuj1, and NF200, at the messenger RNA and protein levels. In contrast, TSP4 silencing had an opposite effect on the expression of neuronal differentiation markers in NG2 cells. Next, the signaling pathway responsible for TSP4-mediated NG2 cell differentiation was investigated. We found that ERK but not p38 and AKT signaling was affected by TSP4 overexpression. Furthermore, when ERK signaling was blocked by the inhibitor U0126, the neuronal marker expression of NG2 cells was substantially increased. Together, these findings suggested that TSP4 promoted neuronal differentiation of NG2 cells by inhibiting ERK/MAPK signaling, revealing a novel role of TSP4 in cell fate specification of NG2 cells.

  14. ngVLA Cryogenic Subsystem Concept

    NASA Astrophysics Data System (ADS)

    Wootten, Al; Urbain, Denis; Grammer, Wes; Durand, S.

    2018-01-01

    The VLA’s success over 35 years of operations stems in part from dramatically upgraded components over the years. The time has come to build a new array to lead the radio astronomical science into its next 40 years. To accomplish that, a next generation VLA (ngVLA) is envisioned to have 214 antennas with diameters of 18m. The core of the array will be centered at the current VLA location, but the arms will extend out to 1000km.The VLA cryogenic subsystem equipment and technology have remained virtually unchanged since the early 1980s. While adequate for a 27-antenna array, scaling the current system for an array of 214 antennas would be prohibitively expensive in terms of operating cost and maintenance. The overall goal is to limit operating cost to within three times the current level, despite having 8 times the number of antennas. To help realize this goal, broadband receivers and compact feeds will be utilized to reduce both the size and number of cryostats required. The current baseline front end concept calls for just two moderately-sized cryostats for the entire 1.2-116 GHz frequency range, as opposed to 8 in the VLA.For the ngVLA cryogenics, our objective is a well-optimized and efficient system that uses state-of-the-art technology to minimize per-antenna power consumption and maximize reliability. Application of modern technologies, such as variable-speed operation for the scroll compressors and cryocooler motor drives, allow the cooling capacity of the system to be dynamically matched to thermal loading in each cryostat. Significantly, power savings may be realized while the maintenance interval of the cryocoolers is also extended.Finally, a receiver designed to minimize thermal loading can produce savings directly translating to lower operating cost when variable-speed drives are used. Multi-layer insulation (MLI) on radiation shields and improved IR filters on feed windows can significantly reduce heat loading.Measurements done on existing cryogenic

  15. Human transcription factor hTAF(II)150 (CIF150) is involved in transcriptional regulation of cell cycle progression.

    PubMed

    Martin, J; Halenbeck, R; Kaufmann, J

    1999-08-01

    Here we present evidence that CIF150 (hTAF(II)150), the human homolog of Drosophila TAF(II)150, plays an important and selective role in establishing gene expression patterns necessary for progression through the cell cycle. Gel filtration experiments demonstrate that CIF150 (hTAF(II)150) seems to be less tightly associated with human transcription factor IID than hTAF(II)130 is associated with hTAF(II)250. The transient functional knockout of CIF150 (hTAF(II)150) protein led to cell cycle arrest at the G(2)/M transition in mammalian cell lines. PCR display analysis with the RNA derived from CIF150-depleted cells indicated that CIF150 (hTAF(II)150) is required for the transcription of only a subset of RNA polymerase II genes. CIF150 (hTAF(II)150) directly stimulated cyclin B1 and cyclin A transcription in cotransfection assays and in vitro assays, suggesting that the expression of these genes is dependent on CIF150 (hTAF(II)150) function. We defined a CIF150 (hTAF(II)150) consensus binding site and demonstrated that a CIF150-responsive cis element is present in the cyclin B1 core promoter. These results suggest that one function of CIF150 (hTAF(II)150) is to select specific RNA polymerase II core promoter elements involved in cell cycle progression.

  16. A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

    PubMed Central

    Zlobec, Inti; Suter, Guido; Perren, Aurel; Lugli, Alessandro

    2014-01-01

    Biomarker research relies on tissue microarrays (TMA). TMAs are produced by repeated transfer of small tissue cores from a ‘donor’ block into a ‘recipient’ block and then used for a variety of biomarker applications. The construction of conventional TMAs is labor intensive, imprecise, and time-consuming. Here, a protocol using next-generation Tissue Microarrays (ngTMA) is outlined. ngTMA is based on TMA planning and design, digital pathology, and automated tissue microarraying. The protocol is illustrated using an example of 134 metastatic colorectal cancer patients. Histological, statistical and logistical aspects are considered, such as the tissue type, specific histological regions, and cell types for inclusion in the TMA, the number of tissue spots, sample size, statistical analysis, and number of TMA copies. Histological slides for each patient are scanned and uploaded onto a web-based digital platform. There, they are viewed and annotated (marked) using a 0.6-2.0 mm diameter tool, multiple times using various colors to distinguish tissue areas. Donor blocks and 12 ‘recipient’ blocks are loaded into the instrument. Digital slides are retrieved and matched to donor block images. Repeated arraying of annotated regions is automatically performed resulting in an ngTMA. In this example, six ngTMAs are planned containing six different tissue types/histological zones. Two copies of the ngTMAs are desired. Three to four slides for each patient are scanned; 3 scan runs are necessary and performed overnight. All slides are annotated; different colors are used to represent the different tissues/zones, namely tumor center, invasion front, tumor/stroma, lymph node metastases, liver metastases, and normal tissue. 17 annotations/case are made; time for annotation is 2-3 min/case. 12 ngTMAs are produced containing 4,556 spots. Arraying time is 15-20 hr. Due to its precision, flexibility and speed, ngTMA is a powerful tool to further improve the quality of TMAs

  17. Debris Disk Studies with the ngVLA

    NASA Astrophysics Data System (ADS)

    Wilner, David; Matthews, Brenda; Matra, Luca; Kennedy, Grant; Wyatt, Mark; Greaves, Jane

    2018-01-01

    We discuss the potential for the ngVLA to advance understanding of debris disks around main-sequence stars. Since the dust-producing planetesimals that replenish these disks through collisions persist only in stable regions like belts and resonances, their locations and physical properties encode essential information about the formation of exoplanetary systems and their dynamical evolution. Observations at long millimeter wavelengths can play a special role because the large grains that dominate the emission are faithful tracers of the dust-producing planetesimals, unlike small grains seen at shorter wavelengths that are rapidly redistributed by stellar radiation and winds. Sensitive observations of debris disks with the ngVLA can (1) reveal structures resulting from otherwise inaccessible planets on wide orbits, (2) test collisional models using spectral slopes to constrain mm/cm grain size distributions, and (3) for select sources, probe the water content of exocomets using the 21 cm HI line.

  18. Assessment of NgR1 Function In Vivo After Spinal Cord Injury

    PubMed Central

    Tong, Jing; Ren, Yi; Wang, Xiaowei; Dimopoulos, Vassilios G.; Kesler, Henry N.; Liu, Weimin; He, Xiaosheng; Nedergaard, Maiken; Huang, Jason H.

    2014-01-01

    Background: Neuronal Nogo-66 receptor 1 (NgR1) has attracted attention as a converging point for mediating the effects of myelin-associate inhibitory ligands in the CNS, establishing the growth restrictive environment, and limiting axon regeneration following traumatic injury. Objective: The importance of NgR1 has been undermined by several studies that have shown the lack of substantial axon regeneration following spinal cord injury (SCI) in NgR1 knockout or knockdown animal models. This study aims to investigate the factors that may be contributing to the discrepancy. Methods: We used mice carrying either a homozygous or heterozygous null mutation in the NgR1 gene and subjected them to either a moderate or severe SCI. Results: Locomotor function assessments revealed that the level of functional recovery is affected by the degree of injury suffered. NgR1 ablation enhanced local collateral sprouting in the mutant mice. Reactive astrocytes and chondroitin sulfate proteoglycans (CSPGs) are upregulated surrounding the injury site. MMP-9, which has been shown to degrade CSPGs, was significantly upregulated in the homozygous mutant mice compared to the heterozygous or wild-type mice. However, CSPG levels remained higher in the homozygous compared to the heterozygous mice, suggesting that CSPG-degrading activity of MMP-9 may require the presence of NgR1. Conclusion: Genetic ablation of NgR1 may lead to significant recovery in locomotor function following SCI. The difference in locomotor recovery we observed between the groups that suffered varying degrees of injury suggests that injury severity may be a confounding factor in functional recovery following SCI. PMID:24594926

  19. 45 CFR 150.325 - Settlement authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Settlement authority. 150.325 Section 150.325 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS... Governmental Plans-Civil Money Penalties § 150.325 Settlement authority. Nothing in §§ 150.315 through 150.323...

  20. 40 CFR 272.150 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false [Reserved] 272.150 Section 272.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arizona § 272.150 [Reserved] ...

  1. 40 CFR 272.150 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false [Reserved] 272.150 Section 272.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arizona § 272.150 [Reserved] ...

  2. 40 CFR 272.150 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false [Reserved] 272.150 Section 272.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arizona § 272.150 [Reserved] ...

  3. 40 CFR 272.150 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false [Reserved] 272.150 Section 272.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arizona § 272.150 [Reserved] ...

  4. 40 CFR 272.150 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false [Reserved] 272.150 Section 272.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arizona § 272.150 [Reserved] ...

  5. Synaptic communication between neurons and NG2+ cells.

    PubMed

    Paukert, Martin; Bergles, Dwight E

    2006-10-01

    Chemical synaptic transmission provides the basis for much of the rapid signaling that occurs within neuronal networks. However, recent studies have provided compelling evidence that synapses are not used exclusively for communication between neurons. Physiological and anatomical studies indicate that a distinct class of glia known as NG2(+) cells also forms direct synaptic junctions with both glutamatergic and GABAergic neurons. Glutamatergic signaling can influence intracellular Ca(2+) levels in NG2(+) cells by activating Ca(2+) permeable AMPA receptors, and these inputs can be potentiated through high frequency stimulation. Although the significance of this highly differentiated form of communication remains to be established, these neuro-glia synapses might enable neurons to influence rapidly the behavior of this ubiquitous class of glial progenitors.

  6. 40 CFR 205.150 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Applicability. 205.150 Section 205.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycles § 205.150 Applicability. (a) Except as otherwise provided in...

  7. 40 CFR 68.150 - Submission.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 15 2011-07-01 2011-07-01 false Submission. 68.150 Section 68.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.150 Submission. (a) The owner or operator shall...

  8. 40 CFR 205.150 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Applicability. 205.150 Section 205.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycles § 205.150 Applicability. (a) Except as otherwise provided in...

  9. 40 CFR 68.150 - Submission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Submission. 68.150 Section 68.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.150 Submission. (a) The owner or operator shall...

  10. 46 CFR 150.115 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Definitions. 150.115 Section 150.115 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.115 Definitions. As used in this subpart: Hazardous material means: (a) A flammable liquid...

  11. 46 CFR 150.115 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Definitions. 150.115 Section 150.115 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.115 Definitions. As used in this subpart: Hazardous material means: (a) A flammable liquid...

  12. 46 CFR 150.115 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Definitions. 150.115 Section 150.115 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.115 Definitions. As used in this subpart: Hazardous material means: (a) A flammable liquid...

  13. 46 CFR 150.115 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Definitions. 150.115 Section 150.115 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.115 Definitions. As used in this subpart: Hazardous material means: (a) A flammable liquid...

  14. 46 CFR 150.115 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Definitions. 150.115 Section 150.115 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.115 Definitions. As used in this subpart: Hazardous material means: (a) A flammable liquid...

  15. 7 CFR 65.150 - Goat.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.150 Goat. Goat means meat produced from goats. ... 7 Agriculture 3 2010-01-01 2010-01-01 false Goat. 65.150 Section 65.150 Agriculture Regulations of...

  16. 7 CFR 65.150 - Goat.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Goat. 65.150 Section 65.150 Agriculture Regulations of..., PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.150 Goat. Goat means meat produced from goats. ...

  17. Health Information in Vietnamese (Tiếng Việt)

    MedlinePlus

    ... Information Translations Salmonella Infections Vaccine Information Statement (VIS) -- Typhoid Vaccines: What You Need to Know - English PDF Vaccine Information Statement (VIS) -- Typhoid Vaccines: What You Need to Know - Tiếng Việt ( ...

  18. NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature

    PubMed Central

    Al-Mayhani, M. Talal F.; Grenfell, Richard; Narita, Masashi; Piccirillo, Sara; Kenney-Herbert, Emma; Fawcett, James W.; Collins, V. Peter; Ichimura, Koichi; Watts, Colin

    2011-01-01

    Glioblastoma multiforme (GBM) is the most common type of primary brain tumor and a highly malignant and heterogeneous cancer. Current conventional therapies fail to eradicate or curb GBM cell growth. Hence, exploring the cellular and molecular basis of GBM cell growth is vital to develop novel therapeutic approaches. Neuroglia (NG)-2 is a transmembrane proteoglycan expressed by NG2+ progenitors and is strongly linked to cell proliferation in the normal brain. By using NG2 as a biomarker we identify a GBM cell population (GBM NG2+ cells) with robust proliferative, clonogenic, and tumorigenic capacity. We show that a significant proportion (mean 83%) of cells proliferating in the tumor mass express NG2 and that over 50% of GBM NG2+ cells are proliferating. Compared with the GBM NG2− cells from the same tumor, the GBM of NG2+ cells overexpress genes associated with aggressive tumorigenicity, including overexpression of Mitosis and Cell Cycling Module genes (e.g., MELK, CDC, MCM, E2F), which have been previously shown to correlate with poor survival in GBM. We also show that the coexpression pattern of NG2 with other glial progenitor markers in GBM does not recapitulate that described in the normal brain. The expression of NG2 by such an aggressive and actively cycling GBM population combined with its location on the cell surface identifies this cell population as a potential therapeutic target in a subset of patients with GBM. PMID:21798846

  19. 10 CFR 150.4 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Communications. 150.4 Section 150.4 Energy NUCLEAR... OFFSHORE WATERS UNDER SECTION 274 General Provisions § 150.4 Communications. Except where otherwise specified in this part, all communications and reports concerning the regulations in this part should be...

  20. 10 CFR 150.4 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Communications. 150.4 Section 150.4 Energy NUCLEAR... OFFSHORE WATERS UNDER SECTION 274 General Provisions § 150.4 Communications. Except where otherwise specified in this part, all communications and reports concerning the regulations in this part should be...

  1. 45 CFR 150.435 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Discovery. 150.435 Section 150.435 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.435 Discovery. (a) The parties must...

  2. 45 CFR 150.413 - Settlement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Settlement. 150.413 Section 150.413 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.413 Settlement. CMS has exclusive...

  3. 45 CFR 150.413 - Settlement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Settlement. 150.413 Section 150.413 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.413 Settlement. CMS has exclusive...

  4. 10 CFR 60.150 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Scope. 60.150 Section 60.150 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Quality Assurance § 60.150 Scope. As used in this part, quality assurance comprises all those planned and systematic...

  5. 10 CFR 150.4 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Communications. 150.4 Section 150.4 Energy NUCLEAR... OFFSHORE WATERS UNDER SECTION 274 General Provisions § 150.4 Communications. Except where otherwise specified in this part, all communications and reports concerning the regulations in this part should be...

  6. 31 CFR 150.2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Definitions. 150.2 Section 150.2 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY FINANCIAL RESEARCH FUND § 150.2 Definitions. As used in this part: Assessed company means...

  7. 45 CFR 150.425 - Motions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Motions. 150.425 Section 150.425 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.425 Motions. (a) Any request to the ALJ...

  8. 45 CFR 150.425 - Motions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Motions. 150.425 Section 150.425 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.425 Motions. (a) Any request to the ALJ...

  9. 21 CFR 820.150 - Storage.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Storage. 820.150 Section 820.150 Food and Drugs... QUALITY SYSTEM REGULATION Handling, Storage, Distribution, and Installation § 820.150 Storage. (a) Each manufacturer shall establish and maintain procedures for the control of storage areas and stock rooms for...

  10. 21 CFR 820.150 - Storage.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Storage. 820.150 Section 820.150 Food and Drugs... QUALITY SYSTEM REGULATION Handling, Storage, Distribution, and Installation § 820.150 Storage. (a) Each manufacturer shall establish and maintain procedures for the control of storage areas and stock rooms for...

  11. 21 CFR 820.150 - Storage.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Storage. 820.150 Section 820.150 Food and Drugs... QUALITY SYSTEM REGULATION Handling, Storage, Distribution, and Installation § 820.150 Storage. (a) Each manufacturer shall establish and maintain procedures for the control of storage areas and stock rooms for...

  12. 21 CFR 820.150 - Storage.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Storage. 820.150 Section 820.150 Food and Drugs... QUALITY SYSTEM REGULATION Handling, Storage, Distribution, and Installation § 820.150 Storage. (a) Each manufacturer shall establish and maintain procedures for the control of storage areas and stock rooms for...

  13. 45 CFR 150.415 - Intervention.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Intervention. 150.415 Section 150.415 Public... ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.415 Intervention. (a) The... intervention will not unduly delay or prejudice the adjudication of the rights of the existing parties. (b) A...

  14. 45 CFR 150.415 - Intervention.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Intervention. 150.415 Section 150.415 Public... ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.415 Intervention. (a) The... intervention will not unduly delay or prejudice the adjudication of the rights of the existing parties. (b) A...

  15. 45 CFR 150.415 - Intervention.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Intervention. 150.415 Section 150.415 Public... ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.415 Intervention. (a) The... intervention will not unduly delay or prejudice the adjudication of the rights of the existing parties. (b) A...

  16. 45 CFR 150.415 - Intervention.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Intervention. 150.415 Section 150.415 Public... ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.415 Intervention. (a) The... intervention will not unduly delay or prejudice the adjudication of the rights of the existing parties. (b) A...

  17. 45 CFR 150.415 - Intervention.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Intervention. 150.415 Section 150.415 Public... ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.415 Intervention. (a) The... intervention will not unduly delay or prejudice the adjudication of the rights of the existing parties. (b) A...

  18. 7 CFR 915.150 - Reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Reports. 915.150 Section 915.150 Agriculture... and Regulations § 915.150 Reports. (a) Each handler shall file with the Avocado Administrative Committee, on a weekly basis, a report of all avocados received by him. Such report shall be on forms...

  19. 7 CFR 915.150 - Reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Reports. 915.150 Section 915.150 Agriculture... and Regulations § 915.150 Reports. (a) Each handler shall file with the Avocado Administrative Committee, on a weekly basis, a report of all avocados received by him. Such report shall be on forms...

  20. 21 CFR 812.150 - Reports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Reports. 812.150 Section 812.150 Food and Drugs... INVESTIGATIONAL DEVICE EXEMPTIONS Records and Reports § 812.150 Reports. (a) Investigator reports. An investigator shall prepare and submit the following complete, accurate, and timely reports: (1) Unanticipated adverse...

  1. 21 CFR 812.150 - Reports.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Reports. 812.150 Section 812.150 Food and Drugs... INVESTIGATIONAL DEVICE EXEMPTIONS Records and Reports § 812.150 Reports. (a) Investigator reports. An investigator shall prepare and submit the following complete, accurate, and timely reports: (1) Unanticipated adverse...

  2. 31 CFR 150.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Scope. 150.1 Section 150.1 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY FINANCIAL RESEARCH FUND § 150.1 Scope. The assessments contained in this part are made pursuant to the...

  3. 45 CFR 150.435 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Discovery. 150.435 Section 150.435 Public Welfare... AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.435 Discovery. (a) The parties must identify any need for discovery from the opposing party as soon as possible, but no later than the time for...

  4. 45 CFR 150.435 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Discovery. 150.435 Section 150.435 Public Welfare... AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.435 Discovery. (a) The parties must identify any need for discovery from the opposing party as soon as possible, but no later than the time for...

  5. 45 CFR 150.435 - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Discovery. 150.435 Section 150.435 Public Welfare... AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.435 Discovery. (a) The parties must identify any need for discovery from the opposing party as soon as possible, but no later than the time for...

  6. 45 CFR 150.435 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 150.435 Section 150.435 Public Welfare... AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.435 Discovery. (a) The parties must identify any need for discovery from the opposing party as soon as possible, but no later than the time for...

  7. Physically Based Rendering in the Nightshade NG Visualization Platform

    NASA Astrophysics Data System (ADS)

    Berglund, Karrie; Larey-Williams, Trystan; Spearman, Rob; Bogard, Arthur

    2015-01-01

    This poster describes our work on creating a physically based rendering model in Nightshade NG planetarium simulation and visualization software (project website: NightshadeSoftware.org). We discuss techniques used for rendering realistic scenes in the universe and dealing with astronomical distances in real time on consumer hardware. We also discuss some of the challenges of rewriting the software from scratch, a project which began in 2011.Nightshade NG can be a powerful tool for sharing data and visualizations. The desktop version of the software is free for anyone to download, use, and modify; it runs on Windows and Linux (and eventually Mac). If you are looking to disseminate your data or models, please stop by to discuss how we can work together.Nightshade software is used in literally hundreds of digital planetarium systems worldwide. Countless teachers and astronomy education groups run the software on flat screens. This wide use makes Nightshade an effective tool for dissemination to educators and the public.Nightshade NG is an especially powerful visualization tool when projected on a dome. We invite everyone to enter our inflatable dome in the exhibit hall to see this software in a 3D environment.

  8. Noble-Gas Difluoride Complexes of Mercury(II): The Syntheses and Structures of Hg(OTeF 5) 2·1.5NgF 2 (Ng = Xe, Kr) and Hg(OTeF 5) 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    DeBackere, John R.; Mercier, Helene P. A; Schrobilgen, Gary J.

    2014-02-03

    The synthesis of high-purity Hg(OTeF 5) 2 has resulted in its structural characterization in the solid state by Raman spectroscopy and single-crystal X-ray diffraction (XRD) and in solution by 19F NMR spectroscopy. The crystal structure of Hg(OTeF 5) 2 (-173 °C) consists of discrete Hg(OTeF 5) 2 units having gauche-conformations that interact through long Hg---O and Hg---F intramolecular contacts to give a chain structure. Furthermore, the Lewis acidity of Hg(OTeF 5) 2 toward NgF 2 (Ng = Xe, Kr) was investigated in SO 2ClF solvent and shown to form stable coordination complexes with NgF 2 at -78 °C. Both complexesmore » were characterized by low-temperature Raman spectroscopy (-155 °C) and single-crystal XRD. The complexes are isostructural and are formulated as Hg(OTeF 5) 2·1.5NgF 2. The Hg(OTeF 5) 2 units of Hg(OTeF 5) 2·1.5NgF 2 also have gauche-conformations and are linked through bridging NgF 2 molecules, also resulting in chain structures. The complexes represent the only examples of coordination compounds where NgF 2 coordinates to mercury in a neutral covalent compound and the only example of mercury coordinated to KrF 2. Moreover, the Hg(OTeF 5) 2·1.5KrF 2 complex is the only KrF 2 complex known to contain a bridging KrF 2 ligand. Energy-minimized gas-phase geometries and vibrational frequencies for the model compounds, [Hg(OTeF5) 2] 3 and [Hg(OTeF 5) 2] 3·2NgF 2, were obtained and provide good approximations of the local environments of Hg(OTeF 5) 2 and NgF 2 in the crystal structures of Hg(OTeF5)2 and Hg(OTeF 5) 2·1.5NgF 2. Assignments of the Raman spectra of Hg(OTeF 5) 2 and Hg(OTeF 5) 2·1.5NgF 2 are based on the calculated vibrational frequencies of the model compounds. Natural bond orbital analyses provided the associated bond orders, valencies, and natural population analysis charges.« less

  9. 40 CFR 45.150 - Reports.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Reports. 45.150 Section 45.150... ASSISTANCE § 45.150 Reports. (a) Recipients must submit the reports required in 40 CFR 30.505. (b) A draft of the final project report is required 90 days before the end of the project period. The recipient shall...

  10. 40 CFR 45.150 - Reports.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Reports. 45.150 Section 45.150... ASSISTANCE § 45.150 Reports. (a) Recipients must submit the reports required in 40 CFR 30.505. (b) A draft of the final project report is required 90 days before the end of the project period. The recipient shall...

  11. Mapping methane emissions using the airborne imaging spectrometer AVIRIS-NG

    NASA Astrophysics Data System (ADS)

    Thorpe, A. K.; Frankenberg, C.; Thompson, D. R.; Duren, R. M.; Bue, B. D.; Green, R. O.

    2017-12-01

    The next generation Airborne Visible/Infrared Imaging Spectrometer (AVIRIS-NG) has been used to survey large regions and map methane plumes with unambiguous identification of emission source locations. This capability is aided by real time detection and geolocation of gas plumes, permitting adaptive surveys and communication to ground teams for rapid follow up. We present results from AVIRIS-NG flight campaigns in Colorado, New Mexico, and California. Hundreds of plumes were observed, reflecting emissions from the energy sector that include hydraulic fracturing, gas processing plants, tanks, pumpjacks, and pipeline leaks. In some cases, plumes observed by AVIRIS-NG resulted in mitigation. Additional examples will be shown for methane from dairy lagoons, landfills, natural emissions, as well as carbon dioxide from power plants and refineries. We describe the unique capabilities of airborne imaging spectrometers to augment other measurement techniques by efficiently surveying key regions for methane point sources and supporting timely assessment and mitigation. We summarize the outlook for near- and longer-term monitoring capabilities including future satellite systems. Figure caption. AVIRIS-NG true color image subset with superimposed methane plume showing retrieved gas concentrations. Plume extends 200 m downwind of the southern edge of the well pad. Google Earth imagery with finer spatial resolution is also included (red box), indicating that tanks in the inset scene as the source of emissions. Five wells are located at the center of this well pad and all use horizontal drilling to produce mostly natural gas.

  12. Lack of NG2 exacerbates neurological outcome and modulates glial responses after traumatic brain injury.

    PubMed

    Huang, Changsheng; Sakry, Dominik; Menzel, Lutz; Dangel, Larissa; Sebastiani, Anne; Krämer, Tobias; Karram, Khalad; Engelhard, Kristin; Trotter, Jacqueline; Schäfer, Michael K E

    2016-04-01

    Traumatic brain injury (TBI) is a major cause of death and disability. The underlying pathophysiology is characterized by secondary processes including neuronal death and gliosis. To elucidate the role of the NG2 proteoglycan we investigated the response of NG2-knockout mice (NG2-KO) to TBI. Seven days after TBI behavioral analysis, brain damage volumetry and assessment of blood brain barrier integrity demonstrated an exacerbated response of NG2-KO compared to wild-type (WT) mice. Reactive astrocytes and expression of the reactive astrocyte and neurotoxicity marker Lcn2 (Lipocalin-2) were increased in the perilesional brain tissue of NG2-KO mice. In addition, microglia/macrophages with activated morphology were increased in number and mRNA expression of the M2 marker Arg1 (Arginase 1) was enhanced in NG2-KO mice. While TBI-induced expression of pro-inflammatory cytokine genes was unchanged between genotypes, PCR array screening revealed a marked TBI-induced up-regulation of the C-X-C motif chemokine 13 gene Cxcl13 in NG2-KO mice. CXCL13, known to attract immune cells to the inflamed brain, was expressed by activated perilesional microglia/macrophages seven days after TBI. Thirty days after TBI, NG2-KO mice still exhibited more pronounced neurological deficits than WT mice, up-regulation of Cxcl13, enhanced CD45+ leukocyte infiltration and a relative increase of activated Iba-1+/CD45+ microglia/macrophages. Our study demonstrates that lack of NG2 exacerbates the neurological outcome after TBI and associates with abnormal activation of astrocytes, microglia/macrophages and increased leukocyte recruitment to the injured brain. These findings suggest that NG2 may counteract neurological deficits and adverse glial responses in TBI. © 2015 Wiley Periodicals, Inc.

  13. NG2/CSPG4 and progranulin in the posttraumatic glial scar.

    PubMed

    Schäfer, Michael K E; Tegeder, Irmgard

    2018-08-01

    Traumatic injury of the central nervous system is one of the leading causes of death and disability in young adults. Failure of regeneration is caused by autonomous neuronal obstacles and by formation of the glial scar, which is essential to seal the injury but also constitutes a barrier for regrowing axons. The scar center is highly inflammatory and populated by NG2+ glia, whereas astrocytes form the sealing border and trap regrowing axons, suggesting that the non-permissive environment of activated astrocytes and extracellular matrix components is one of the reasons for the regenerative failure. Particularly, secreted chondroitin-sulfate proteoglycans, CSPGs, of the lectican family hinder axonal regrowth. In contrast, the transmembrane CSPG, NG2/CSPG4, appears to be functionally closer related to axon growth permissive heparan sulfate proteoglycans, HSPGs, and synaptic adhesion molecules, which all regulate synaptic signaling and plasticity upon alpha-secretase mediated shedding. Consequently, knockout of NG2/CSPG4 aggravates tissue loss, inflammation and neurologic deficits after brain injury, a phenotype partly mimicked by deletion of HSPG-binding proteins such as the HSPG2/perlecan-interacting protein, progranulin that is also a functional ligand of Notch and Eph2a. Indeed, structural features or progranulin's targets and NG2 may point to direct reciprocal regulations that may act in concert to overcome injury-evoked inflammation and neuronal dystrophy. This review provides an overview of the pathophysiology of the glial scar after brain injury, with a specific focus on NG2/CSPG4, its functions before and after shedding and putative reciprocal influences with the glycoprotein progranulin. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. No evidence of genome editing activity from Natronobacterium gregoryi Argonaute (NgAgo) in human cells.

    PubMed

    Javidi-Parsijani, Parisa; Niu, Guoguang; Davis, Meghan; Lu, Pin; Atala, Anthony; Lu, Baisong

    2017-01-01

    The argonaute protein from the thermophilic bacterium Thermus thermophilus shows DNA-guided DNA interfering activity at high temperatures, complicating its application in mammalian cells. A recent work reported that the argonaute protein from Natronobacterium gregoryi (NgAgo) had DNA-guided genome editing activity in mammalian cells. We compared the genome editing activities of NgAgo and Staphylococcus aureus Cas9 (SaCas9) in human HEK293T cells side by side. EGFP reporter assays and DNA sequencing consistently revealed high genome editing activity from SaCas9. However, these assays did not demonstrate genome editing activity by NgAgo. We confirmed that the conditions allowed simultaneous transfection of the NgAgo expressing plasmid DNA and DNA guides, as well as heterologous expression of NgAgo in the HEK293T cells. Our data show that NgAgo is not a robust genome editing tool, although it may have such activity under other conditions.

  15. 44 CFR 150.7 - Selection process.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... HOMELAND SECURITY FIRE PREVENTION AND CONTROL PUBLIC SAFETY AWARDS TO PUBLIC SAFETY OFFICERS § 150.7... § 150.3 and the criteria prescribed in § 150.4(a)(2). In reviewing nominations, the Attorney General or...

  16. 44 CFR 150.7 - Selection process.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... HOMELAND SECURITY FIRE PREVENTION AND CONTROL PUBLIC SAFETY AWARDS TO PUBLIC SAFETY OFFICERS § 150.7... § 150.3 and the criteria prescribed in § 150.4(a)(2). In reviewing nominations, the Attorney General or...

  17. IASI-NG: a new generation of infrared sounders for meteorology and atmospheric composition

    NASA Astrophysics Data System (ADS)

    Deschamps, A.; Bermudo, F.; Rousseau, S.; Bernard, F.; Pequignot, E.

    2016-12-01

    IASI-NG is the main payload of the future Metop-SG satellite of the Eumetsat EPS-SG program. This infrared atmospheric sounder generates radiance spectra at high resolution between 645cm-1 and 2760cm-1 and takes benefits from the IASI heritage. As for the first generation, the development of IASI-NG is under CNES responsibility. The first goal of the IASI-NG mission is to support Numerical Weather Prediction (NWP) by improving the estimation of humidity and temperature profiles, especially in the troposphere. To reach this goal, the spectral resolution will be two times better than for IASI first generation, and the radiometric noise will be divided by a factor of two. These performances will enable to support pollution monitoring, climate and atmospheric composition studies as well. CH4 and CO2 columns (but also O3, SO2, CO, NH3, HNO3 concentrations) are some of the products which will be derived from the IASI-NG measurements, in addition to NWP products (such as temperature and water vapor profiles, surface temperature and cloud information). This presentation describes in a first part the main characteristics of the instrument, which allow it to reach this level of performances. The interferometer, developed by Airbus Defense and Space, is based on the Mertz concept and allows to assess the self apodization by a field effect compensation (IASI-NG will be the first mission to implement Mertz Interferometer). In a second part, we present the main performances of the IASI-NG system, in terms of radiometric noise, spectral resolution and geolocation. We describe also the main algorithms which will be used in the ground segment to calibrate the data and correct the instrumental effects. Lastly, we give some information about the status of the project which is currently is the C/D phase and the major milestones in the IASI-NG agenda.

  18. 12 CFR 150.150 - Who is responsible for the exercise of fiduciary powers?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Who is responsible for the exercise of... and Facilities § 150.150 Who is responsible for the exercise of fiduciary powers? The exercise of your... responsibilities, the board may assign any function related to the exercise of fiduciary powers to any director...

  19. 12 CFR 150.150 - Who is responsible for the exercise of fiduciary powers?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Who is responsible for the exercise of... and Facilities § 150.150 Who is responsible for the exercise of fiduciary powers? The exercise of your... responsibilities, the board may assign any function related to the exercise of fiduciary powers to any director...

  20. 12 CFR 150.150 - Who is responsible for the exercise of fiduciary powers?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Who is responsible for the exercise of... and Facilities § 150.150 Who is responsible for the exercise of fiduciary powers? The exercise of your... responsibilities, the board may assign any function related to the exercise of fiduciary powers to any director...

  1. 7 CFR 1726.150 - Headquarters buildings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Headquarters buildings. 1726.150 Section 1726.150 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Buildings § 1726.150 Headquarters buildings...

  2. 40 CFR 1065.150 - Continuous sampling.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Continuous sampling. 1065.150 Section 1065.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use continuous...

  3. 40 CFR 1065.150 - Continuous sampling.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Continuous sampling. 1065.150 Section 1065.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use continuous...

  4. 40 CFR 1065.150 - Continuous sampling.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Continuous sampling. 1065.150 Section 1065.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use continuous...

  5. 46 CFR 125.150 - Lifesaving systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Lifesaving systems. 125.150 Section 125.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS GENERAL § 125.150 Lifesaving systems. Lifesaving appliances and arrangements must comply with part 133 of this subchapter. ...

  6. 46 CFR 125.150 - Lifesaving systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Lifesaving systems. 125.150 Section 125.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS GENERAL § 125.150 Lifesaving systems. Lifesaving appliances and arrangements must comply with part 133 of this subchapter. ...

  7. 45 CFR 150.441 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Prehearing conferences. 150.441 Section 150.441 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.441 Prehearing conferences...

  8. 45 CFR 150.451 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Posthearing briefs. 150.451 Section 150.451 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.451 Posthearing briefs...

  9. 41 CFR 105-1.150 - Citation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Citation. 105-1.150 Section 105-1.150 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.150 Citation. (a...

  10. 30 CFR 817.150 - Roads: General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... (e) Maintenance. (1) A road shall be maintained to meet the performance standards of this part and... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Roads: General. 817.150 Section 817.150 Mineral... PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-UNDERGROUND MINING ACTIVITIES § 817.150 Roads...

  11. 30 CFR 816.150 - Roads: general.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... (e) Maintenance. (1) A road shall be maintained to meet the performance standards of this part and... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Roads: general. 816.150 Section 816.150 Mineral... PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-SURFACE MINING ACTIVITIES § 816.150 Roads...

  12. 29 CFR 1926.150 - Fire protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Fire protection. 1926.150 Section 1926.150 Labor... (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Fire Protection and Prevention § 1926.150 Fire protection. (a) General requirements. (1) The employer shall be responsible for the development of a fire...

  13. 10 CFR 150.10 - Persons exempt.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Persons exempt. 150.10 Section 150.10 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXEMPTIONS AND CONTINUED REGULATORY AUTHORITY IN AGREEMENT STATES AND IN OFFSHORE WATERS UNDER SECTION 274 Exemptions in Agreement States § 150.10 Persons exempt. Except as...

  14. 10 CFR 150.10 - Persons exempt.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Persons exempt. 150.10 Section 150.10 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXEMPTIONS AND CONTINUED REGULATORY AUTHORITY IN AGREEMENT STATES AND IN OFFSHORE WATERS UNDER SECTION 274 Exemptions in Agreement States § 150.10 Persons exempt. Except as...

  15. 10 CFR 150.10 - Persons exempt.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Persons exempt. 150.10 Section 150.10 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXEMPTIONS AND CONTINUED REGULATORY AUTHORITY IN AGREEMENT STATES AND IN OFFSHORE WATERS UNDER SECTION 274 Exemptions in Agreement States § 150.10 Persons exempt. Except as...

  16. 10 CFR 150.10 - Persons exempt.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Persons exempt. 150.10 Section 150.10 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXEMPTIONS AND CONTINUED REGULATORY AUTHORITY IN AGREEMENT STATES AND IN OFFSHORE WATERS UNDER SECTION 274 Exemptions in Agreement States § 150.10 Persons exempt. Except as...

  17. 7 CFR 4279.150 - Feasibility studies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Feasibility studies. 4279.150 Section 4279.150... § 4279.150 Feasibility studies. A feasibility study by a qualified independent consultant may be required... affect the borrower's operations. An acceptable feasibility study should include, but not be limited to...

  18. 7 CFR 4279.150 - Feasibility studies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Feasibility studies. 4279.150 Section 4279.150... § 4279.150 Feasibility studies. A feasibility study by a qualified independent consultant may be required... affect the borrower's operations. An acceptable feasibility study should include, but not be limited to...

  19. 25 CFR 30.150 - Information collection.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Information collection. 30.150 Section 30.150 Indians... and Accountability § 30.150 Information collection. Notwithstanding any other provision of law, no..., a collection of information subject to the requirements of the Paperwork Reduction Act of 1995 (44 U...

  20. 45 CFR 150.453 - ALJ decision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false ALJ decision. 150.453 Section 150.453 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.453 ALJ decision. The ALJ...

  1. 38 CFR 51.150 - Physician services.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Physician services. 51.150 Section 51.150 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) PER DIEM FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.150 Physician services. A...

  2. 38 CFR 51.150 - Physician services.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Physician services. 51.150 Section 51.150 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) PER DIEM FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.150 Physician services. A...

  3. 38 CFR 51.150 - Physician services.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Physician services. 51.150 Section 51.150 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) PER DIEM FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.150 Physician services. A...

  4. 38 CFR 51.150 - Physician services.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Physician services. 51.150 Section 51.150 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) PER DIEM FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.150 Physician services. A...

  5. 38 CFR 51.150 - Physician services.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Physician services. 51.150 Section 51.150 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) PER DIEM FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.150 Physician services. A...

  6. 21 CFR 133.150 - Hard cheeses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Hard cheeses. 133.150 Section 133.150 Food and... CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.150 Hard cheeses. (a) The cheeses for which definitions and standards of identity are...

  7. 21 CFR 211.150 - Distribution procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Distribution procedures. 211.150 Section 211.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Holding and Distribution § 211.150 Distribution procedures. Written...

  8. 21 CFR 211.150 - Distribution procedures.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Distribution procedures. 211.150 Section 211.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Holding and Distribution § 211.150 Distribution procedures. Written...

  9. 21 CFR 211.150 - Distribution procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 4 2012-04-01 2012-04-01 false Distribution procedures. 211.150 Section 211.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Holding and Distribution § 211.150 Distribution procedures. Written...

  10. 21 CFR 211.150 - Distribution procedures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 4 2013-04-01 2013-04-01 false Distribution procedures. 211.150 Section 211.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Holding and Distribution § 211.150 Distribution procedures. Written...

  11. 21 CFR 211.150 - Distribution procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Distribution procedures. 211.150 Section 211.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Holding and Distribution § 211.150 Distribution procedures. Written...

  12. 7 CFR 701.150 - 2005 hurricanes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false 2005 hurricanes. 701.150 Section 701.150 Agriculture... 2005 hurricanes. In addition benefits elsewhere allowed by this part, claims related to calendar year 2005 hurricane losses may be allowed to the extent provided for in §§ 701.150 through 701.157. Such...

  13. 7 CFR 701.150 - 2005 hurricanes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false 2005 hurricanes. 701.150 Section 701.150 Agriculture... 2005 hurricanes. In addition benefits elsewhere allowed by this part, claims related to calendar year 2005 hurricane losses may be allowed to the extent provided for in §§ 701.150 through 701.157. Such...

  14. 7 CFR 701.150 - 2005 hurricanes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false 2005 hurricanes. 701.150 Section 701.150 Agriculture... 2005 hurricanes. In addition benefits elsewhere allowed by this part, claims related to calendar year 2005 hurricane losses may be allowed to the extent provided for in §§ 701.150 through 701.157. Such...

  15. 7 CFR 701.150 - 2005 hurricanes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false 2005 hurricanes. 701.150 Section 701.150 Agriculture... 2005 hurricanes. In addition benefits elsewhere allowed by this part, claims related to calendar year 2005 hurricane losses may be allowed to the extent provided for in §§ 701.150 through 701.157. Such...

  16. Gray Matter NG2 Cells Display Multiple Ca2+-Signaling Pathways and Highly Motile Processes

    PubMed Central

    Haseleu, Julia; Pohle, Jörg; Karram, Khalad; Trotter, Jacqueline; Seifert, Gerald; Frotscher, Michael; Steinhäuser, Christian; Jabs, Ronald

    2011-01-01

    NG2 cells, the fourth type of glia in the mammalian CNS, receive synaptic input from neurons. The function of this innervation is unknown yet. Postsynaptic changes in intracellular Ca2+-concentration ([Ca2+]i) might be a possible consequence. We employed transgenic mice with fluorescently labeled NG2 cells to address this issue. To identify Ca2+-signaling pathways we combined patch-clamp recordings, Ca2+-imaging, mRNA-transcript analysis and focal pressure-application of various substances to identified NG2-cells in acute hippocampal slices. We show that activation of voltage-gated Ca2+-channels, Ca2+-permeable AMPA-receptors, and group I metabotropic glutamate-receptors provoke [Ca2+]i-elevations in NG2 cells. The Ca2+-influx is amplified by Ca2+-induced Ca2+-release. Minimal electrical stimulation of presynaptic neurons caused postsynaptic currents but no somatic [Ca2+]i elevations, suggesting that [Ca2+]i elevations in NG2 cells might be restricted to their processes. Local Ca2+-signaling might provoke transmitter release or changes in cell motility. To identify structural prerequisites for such a scenario, we used electron microscopy, immunostaining, mRNA-transcript analysis, and time lapse imaging. We found that NG2 cells form symmetric and asymmetric synapses with presynaptic neurons and show immunoreactivity for vesicular glutamate transporter 1. The processes are actin-based, contain ezrin but not glial filaments, microtubules or endoplasmic reticulum. Furthermore, we demonstrate that NG2 cell processes in situ are highly motile. Our findings demonstrate that gray matter NG2 cells are endowed with the cellular machinery for two-way communication with neighboring cells. PMID:21455301

  17. 21 CFR 139.150 - Noodle products.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Noodle products. 139.150 Section 139.150 Food and... CONSUMPTION MACARONI AND NOODLE PRODUCTS Requirements for Specific Standardized Macaroni and Noodle Products § 139.150 Noodle products. (a) Noodle products are the class of food each of which is prepared by drying...

  18. 40 CFR 170.150 - Decontamination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Decontamination. 170.150 Section 170... PROTECTION STANDARD Standard for Workers § 170.150 Decontamination. (a)(1) Requirement. The agricultural employer must provide decontamination supplies for workers in accordance with this section whenever: (i...

  19. 42 CFR 423.150 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 423.150 Section 423.150 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Cost Control and Quality Improvement Requirements...

  20. 46 CFR 150.120 - Definition of incompatible cargoes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Definition of incompatible cargoes. 150.120 Section 150.120 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.120 Definition of incompatible cargoes. Except as described in § 150.150, a cargo...

  1. 46 CFR 150.120 - Definition of incompatible cargoes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Definition of incompatible cargoes. 150.120 Section 150.120 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.120 Definition of incompatible cargoes. Except as described in § 150.150, a cargo...

  2. 46 CFR 150.120 - Definition of incompatible cargoes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Definition of incompatible cargoes. 150.120 Section 150.120 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.120 Definition of incompatible cargoes. Except as described in § 150.150, a cargo...

  3. 46 CFR 150.120 - Definition of incompatible cargoes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Definition of incompatible cargoes. 150.120 Section 150.120 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.120 Definition of incompatible cargoes. Except as described in § 150.150, a cargo...

  4. 46 CFR 150.120 - Definition of incompatible cargoes.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Definition of incompatible cargoes. 150.120 Section 150.120 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.120 Definition of incompatible cargoes. Except as described in § 150.150, a cargo...

  5. Optical levitation of 10-ng spheres with nano-g acceleration sensitivity

    NASA Astrophysics Data System (ADS)

    Monteiro, Fernando; Ghosh, Sumita; Fine, Adam Getzels; Moore, David C.

    2017-12-01

    We demonstrate optical levitation of SiO2 spheres with masses ranging from 0.1 to 30 ng. In high vacuum, we observe that the measured acceleration sensitivity improves for larger masses and obtain a sensitivity of 0.4 ×10-6g /√{Hz } for a 12-ng sphere, more than an order of magnitude better than previously reported for optically levitated masses. In addition, these techniques permit long integration times and a mean acceleration of (-0.7 ±2.4 [stat] ±0.2 [syst] ) ×10-9g is measured in 1.4 ×104 s. Spheres larger than 10 ng are found to lose mass in high vacuum where heating due to absorption of the trapping laser dominates radiative cooling. This absorption constrains the maximum size of spheres that can be levitated and allows a measurement of the absorption of the trapping light for the commercially available spheres tested here. Spheres consisting of material with lower absorption may allow larger objects to be optically levitated in high vacuum.

  6. 21 CFR 820.150 - Storage.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Storage. 820.150 Section 820.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES... product to prevent mixups, damage, deterioration, contamination, or other adverse effects pending use or...

  7. 21 CFR 556.150 - Chlortetracycline.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Chlortetracycline. 556.150 Section 556.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS TOLERANCES FOR RESIDUES OF NEW ANIMAL DRUGS IN FOOD Specific...

  8. The fusarin analogue NG-391 impairs nucleic acid formation in K-562 leukemia cells

    USDA-ARS?s Scientific Manuscript database

    The clavicipitaceous fungus Metarhizium robertsii produces the fusarin-like mycotoxin NG-391. We report on the biological effects of NG-391 on K-562 human cancer cells, obtained with radionuclide incorporation assays, along with nucleosome release and caspase assays, respectively. Our data suggests ...

  9. Age-Dependent Netrin-1 Signaling Regulates NG2+ Glial Cell Spatial Homeostasis in Normal Adult Gray Matter

    PubMed Central

    Birey, Fikri

    2015-01-01

    Neuron–glial antigen 2-positive (NG2+) glial cells are the most proliferative glia type in the adult CNS, and their tile-like arrangement in adult gray matter is under tight regulation. However, little is known about the cues that govern this unique distribution. To this end, using a NG2+ glial cell ablation model in mice, we examined the repopulation dynamics of NG2+ glial cells in the mature and aged mice gray matter. We found that some resident NG2+ glial cells that escaped depletion rapidly enter the cell cycle to repopulate the cortex with altered spatial distribution. We reveal that netrin-1 signaling is involved in the NG2+ glial cell early proliferative, late repopulation, and distribution response after ablation in the gray matter. However, ablation of NG2+ glial cell in older animals failed to stimulate a similar repopulation response, possibly because of a decrease in the sensitivity to netrin-1. Our findings indicate that endogenous netrin-1 plays a role in NG2+ glial cell homeostasis that is distinct from its role in myelination. PMID:25926469

  10. 44 CFR 150.9 - Funding.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Funding. 150.9 Section 150.9 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY... defense officer. If the award recipient is a law enforcement officer, then such cost shall be borne by the...

  11. 44 CFR 150.9 - Funding.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Funding. 150.9 Section 150.9 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY... defense officer. If the award recipient is a law enforcement officer, then such cost shall be borne by the...

  12. 37 CFR 41.150 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Discovery. 41.150 Section 41... COMMERCE PRACTICE BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES Contested Cases § 41.150 Discovery. (a) Limited discovery. A party is not entitled to discovery except as authorized in this subpart. The...

  13. 37 CFR 41.150 - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Discovery. 41.150 Section 41... COMMERCE PRACTICE BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES Contested Cases § 41.150 Discovery. (a) Limited discovery. A party is not entitled to discovery except as authorized in this subpart. The...

  14. 45 CFR 150.401 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Definitions. 150.401 Section 150.401 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS... Appeals Board of the Department of Health and Human Services. Filing date means the date postmarked by the...

  15. 37 CFR 41.150 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Discovery. 41.150 Section 41... COMMERCE PRACTICE BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES Contested Cases § 41.150 Discovery. (a) Limited discovery. A party is not entitled to discovery except as authorized in this subpart. The...

  16. Getting the Big Picture: Design Considerations for a ngVLA Short Spacing Array

    NASA Astrophysics Data System (ADS)

    Mason, Brian Scott; Cotton, William; Condon, James; Kepley, Amanda; Selina, Rob; Murphy, Eric Joseph

    2018-01-01

    The Next Generation VLA (ngVLA) aims to provide a revolutionary increase in cm-wavelength collecting area and sensitivity while at the same time providing excellent image fidelity for a broad spectrum of science cases. Likely ngVLA configurations currently envisioned provide sensitivity over a very wide range of spatial scales. The antenna diameter (notionally 18 meters) fundamentally limits the largest angular scales that can be reached. One simple and powerful way to image larger angular scales is to build a complementary interferometer comprising a smaller number of smaller-diameter dishes.We have investigated the requirements that such an array would need to meet in order to usefully scientifically complement the ngVLA; this poster presents the results of our investigation.

  17. 46 CFR 150.110 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Applicability. 150.110 Section 150.110 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF... dangerous cargoes in bulk that are subject to 46 U.S.C. Chapter 37. [CGD 95-028, 62 FR 51209, Sept. 30, 1997] ...

  18. 46 CFR 150.110 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Applicability. 150.110 Section 150.110 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF... dangerous cargoes in bulk that are subject to 46 U.S.C. Chapter 37. [CGD 95-028, 62 FR 51209, Sept. 30, 1997] ...

  19. 46 CFR 150.110 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Applicability. 150.110 Section 150.110 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF... dangerous cargoes in bulk that are subject to 46 U.S.C. Chapter 37. [CGD 95-028, 62 FR 51209, Sept. 30, 1997] ...

  20. 46 CFR 150.110 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Applicability. 150.110 Section 150.110 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF... dangerous cargoes in bulk that are subject to 46 U.S.C. Chapter 37. [CGD 95-028, 62 FR 51209, Sept. 30, 1997] ...

  1. 46 CFR 150.110 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Applicability. 150.110 Section 150.110 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF... dangerous cargoes in bulk that are subject to 46 U.S.C. Chapter 37. [CGD 95-028, 62 FR 51209, Sept. 30, 1997] ...

  2. 32 CFR 150.23 - Motions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Motions. 150.23 Section 150.23 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF.... Motions, pleading, and other papers desired to be filed with the Court may be combined in the same...

  3. 32 CFR 150.23 - Motions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Motions. 150.23 Section 150.23 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF.... Motions, pleading, and other papers desired to be filed with the Court may be combined in the same...

  4. 32 CFR 150.23 - Motions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Motions. 150.23 Section 150.23 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF.... Motions, pleading, and other papers desired to be filed with the Court may be combined in the same...

  5. 32 CFR 150.23 - Motions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Motions. 150.23 Section 150.23 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF.... Motions, pleading, and other papers desired to be filed with the Court may be combined in the same...

  6. 32 CFR 150.23 - Motions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Motions. 150.23 Section 150.23 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF.... Motions, pleading, and other papers desired to be filed with the Court may be combined in the same...

  7. 37 CFR 41.150 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Discovery. 41.150 Section 41... COMMERCE PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Contested Cases § 41.150 Discovery. (a) Limited discovery. A party is not entitled to discovery except as authorized in this subpart. The parties may agree...

  8. 37 CFR 41.150 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Discovery. 41.150 Section 41... COMMERCE PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Contested Cases § 41.150 Discovery. (a) Limited discovery. A party is not entitled to discovery except as authorized in this subpart. The parties may agree...

  9. Weasel works SA-150: Design study of a 100 to 150 passenger transport aircraft

    NASA Technical Reports Server (NTRS)

    Alkema, Kevin; Comeaux, Michael; Gilbert, Timothy; Para, Victor; Toepfer, George

    1993-01-01

    As the year 2000 rapidly approaches, the airlines are faced with an extremely competitive and environmentally restrictive marketplace. In order to survive, commercial air carriers will need to find new ways to lower their direct operating costs, increase load factors and comply with tightening federal and international constraints. The SA-150 has been designed to meet these demands by focusing on the areas of aerodynamic efficiency, an improved level of passenger comfort, and a limited application of advanced technology. The SA-150 has been optimized for a 500 nmi. mission to help the airlines meet the challenges of the short haul, quick turnaround flight. With a maximum capacity of 124 passengers, and full baggage, the SA-150 is also capable of covering a range of 1500 nmi. This additional range capability will provide the airlines with flexibility when scheduling their routes. The aircraft features a 'V' tail, fly-by-wire system and is powered by two turbofans mounted under a twelve aspect ratio wing. The SA-150 will have an initial production run of 800 units and have a purchase price of $37.7 million in 1993 dollars.

  10. Mutation of NgBR, a subunit of cis-prenyltransferase, causes a congenial disorder of glycosylation

    PubMed Central

    Park, Eon Joo; Grabińska, Kariona A.; Guan, Ziqiang; Stránecký, Viktor; Hartmannová, Hana; Hodaňová, Kateřina; Barešová, Veronika; Sovová, Jana; Jozsef, Levente; Ondrušková, Nina; Hansíková, Hana; Honzík, Tomáš; Zeman, Jiří; Hůlková, Helena; Wen, Rong; Kmoch, Stanislav; Sessa, William C.

    2014-01-01

    Summary Dolichol is an obligate carrier of glycans for N-linked protein glycosylation, O-mannosylation, and GPI anchor biosynthesis. Cis-prenyltransferase (cis-PTase) is the first enzyme committed to the synthesis of dolichol. However, the proteins responsible for mammalian cis-PTase activity have not been delineated. Here we show that Nogo-B receptor (NgBR) is a subunit required for dolichol synthesis in yeast, mice and man. Moreover, we describe a family with a congenital disorder of glycosylation caused by a loss of function mutation in the conserved C terminus of NgBR-R290H and show that fibroblasts isolated from patients exhibit reduced dolichol profiles and enhanced accumulation of free cholesterol identically to fibroblasts from mice lacking NgBR. Mutation of NgBR-R290H in man and orthologs in yeast proves the importance of this evolutionarily conserved residue for mammalian cis-PTase activity and function. Thus, these data provides a genetic basis for the essential role of NgBR in dolichol synthesis and protein glycosylation. PMID:25066056

  11. A simulated observation database to assess the impact of the IASI-NG hyperspectral infrared sounder

    NASA Astrophysics Data System (ADS)

    Andrey-Andrés, Javier; Fourrié, Nadia; Guidard, Vincent; Armante, Raymond; Brunel, Pascal; Crevoisier, Cyril; Tournier, Bernard

    2018-02-01

    The highly accurate measurements of the hyperspectral Infrared Atmospheric Sounding Interferometer (IASI) are used in numerical weather prediction (NWP), atmospheric chemistry and climate monitoring. As the second generation of the European Polar System (EPS-SG) is being developed, a new generation of IASI instruments has been designed to fly on board the MetOp-SG constellation: IASI New Generation (IASI-NG). In order to prepare the arrival of this new instrument, and to evaluate its impact on NWP and atmospheric chemistry applications, a set of IASI and IASI-NG simulated data was built and made available to the public to set a common framework for future impact studies. This paper describes the information available in this database and the procedure followed to run the IASI and IASI-NG simulations. These simulated data were evaluated by comparing IASI-NG to IASI observations. The result is also presented here. Additionally, preliminary impact studies of the benefit of IASI-NG compared to IASI on the retrieval of temperature and humidity in a NWP framework are also shown in the present work. With a channel dataset located in the same wave numbers for both instruments, we showed an improvement of the temperature retrievals throughout the atmosphere, with a maximum in the troposphere with IASI-NG and a lower benefit for the tropospheric humidity.

  12. LO LIỆU CHO CÁC ĐỐNG ĐỔ NÁT SAU THIÊN TAI

    EPA Pesticide Factsheets

    KÉO CÁC ĐỒ ĐẠC ĐỔ NÁT SAU TRẬN BÃO RA LỀ ĐƯỜNG TẠI CÁC VÙNG CÓ THAM GIA. Làm theo các hướng dẫn (PDF) sau đây sẽ làm cho quy trình lấy đồ bỏ đi được nhanh hơn. Kiểm lại với chính quyền tại địa phương của quý vị về những gì hiện có cho mình.

  13. 21 CFR 522.150 - Azaperone.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Azaperone. 522.150 Section 522.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS... aggressiveness when mixing or regrouping weanling or feeder pigs weighing up to 80 pounds. (2) Dosage. 2.2 mg per...

  14. 21 CFR 522.150 - Azaperone.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Azaperone. 522.150 Section 522.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS... aggressiveness when mixing or regrouping weanling or feeder pigs weighing up to 80 pounds. (2) Dosage. 2.2 mg per...

  15. 21 CFR 522.150 - Azaperone.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Azaperone. 522.150 Section 522.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS... aggressiveness when mixing or regrouping weanling or feeder pigs weighing up to 80 pounds. (2) Dosage. 2.2 mg per...

  16. 21 CFR 522.150 - Azaperone.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Azaperone. 522.150 Section 522.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS... aggressiveness when mixing or regrouping weanling or feeder pigs weighing up to 80 pounds. (2) Dosage. 2.2 mg per...

  17. 21 CFR 522.150 - Azaperone.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Azaperone. 522.150 Section 522.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS... aggressiveness when mixing or regrouping weanling or feeder pigs weighing up to 80 pounds. (2) Dosage. 2.2 mg per...

  18. Age-Dependent Netrin-1 Signaling Regulates NG2+ Glial Cell Spatial Homeostasis in Normal Adult Gray Matter.

    PubMed

    Birey, Fikri; Aguirre, Adan

    2015-04-29

    Neuron-glial antigen 2-positive (NG2(+)) glial cells are the most proliferative glia type in the adult CNS, and their tile-like arrangement in adult gray matter is under tight regulation. However, little is known about the cues that govern this unique distribution. To this end, using a NG2(+) glial cell ablation model in mice, we examined the repopulation dynamics of NG2(+) glial cells in the mature and aged mice gray matter. We found that some resident NG2(+) glial cells that escaped depletion rapidly enter the cell cycle to repopulate the cortex with altered spatial distribution. We reveal that netrin-1 signaling is involved in the NG2(+) glial cell early proliferative, late repopulation, and distribution response after ablation in the gray matter. However, ablation of NG2(+) glial cell in older animals failed to stimulate a similar repopulation response, possibly because of a decrease in the sensitivity to netrin-1. Our findings indicate that endogenous netrin-1 plays a role in NG2(+) glial cell homeostasis that is distinct from its role in myelination. Copyright © 2015 the authors 0270-6474/15/356946-06$15.00/0.

  19. 7 CFR 1956.150 - OMB control number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true OMB control number. 1956.150 Section 1956.150 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) DEBT SETTLEMENT Debt Settlement-Community and Business Programs § 1956.150...

  20. 40 CFR 52.150 - Yavapai-Apache Reservation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Yavapai-Apache Reservation. 52.150 Section 52.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.150 Yavapai-Apache Reservation. (a...

  1. 40 CFR 52.150 - Yavapai-Apache Reservation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Yavapai-Apache Reservation. 52.150 Section 52.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.150 Yavapai-Apache Reservation. (a...

  2. 40 CFR 52.150 - Yavapai-Apache Reservation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Yavapai-Apache Reservation. 52.150 Section 52.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.150 Yavapai-Apache Reservation. (a...

  3. 40 CFR 52.150 - Yavapai-Apache Reservation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Yavapai-Apache Reservation. 52.150 Section 52.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.150 Yavapai-Apache Reservation. (a...

  4. 40 CFR 52.150 - Yavapai-Apache Reservation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Yavapai-Apache Reservation. 52.150 Section 52.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.150 Yavapai-Apache Reservation. (a...

  5. 45 CFR 400.150 - General eligibility requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true General eligibility requirements. 400.150 Section 400.150 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Refugee Social Services Conditions of Eligibility for Refugee Social Services § 400.150 General...

  6. 45 CFR 400.150 - General eligibility requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false General eligibility requirements. 400.150 Section 400.150 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Refugee Social Services Conditions of Eligibility for Refugee Social Services § 400.150 General...

  7. 45 CFR 400.150 - General eligibility requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false General eligibility requirements. 400.150 Section 400.150 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Refugee Social Services Conditions of Eligibility for Refugee Social Services § 400.150 General...

  8. 45 CFR 400.150 - General eligibility requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true General eligibility requirements. 400.150 Section 400.150 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Refugee Social Services Conditions of Eligibility for Refugee Social Services § 400.150 General...

  9. 45 CFR 400.150 - General eligibility requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false General eligibility requirements. 400.150 Section 400.150 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Refugee Social Services Conditions of Eligibility for Refugee Social Services § 400.150 General...

  10. 38 CFR 59.150 - Domiciliary care requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Domiciliary care requirements. 59.150 Section 59.150 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.150 Domiciliary care...

  11. 7 CFR 762.150 - Interest assistance program.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Interest assistance program. 762.150 Section 762.150 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS GUARANTEED FARM LOANS § 762.150 Interest assistance program. (a) Requests for...

  12. 7 CFR 1924.150 - OMB Control Number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false OMB Control Number. 1924.150 Section 1924.150 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS... REGULATIONS CONSTRUCTION AND REPAIR Planning and Performing Site Development Work § 1924.150 OMB Control...

  13. 44 CFR 150.8 - Presentation of awards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Presentation of awards. 150.8 Section 150.8 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY FIRE PREVENTION AND CONTROL PUBLIC SAFETY AWARDS TO PUBLIC SAFETY OFFICERS § 150.8...

  14. 7 CFR 765.104-765.150 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false [Reserved] 765.104-765.150 Section 765.104-765.150 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS DIRECT LOAN SERVICING-REGULAR Borrower Graduation §§ 765.104-765.150 [Reserved] ...

  15. 7 CFR 765.104-765.150 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false [Reserved] 765.104-765.150 Section 765.104-765.150 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS DIRECT LOAN SERVICING-REGULAR Borrower Graduation §§ 765.104-765.150 [Reserved] ...

  16. 7 CFR 765.104-765.150 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false [Reserved] 765.104-765.150 Section 765.104-765.150 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS DIRECT LOAN SERVICING-REGULAR Borrower Graduation §§ 765.104-765.150 [Reserved] ...

  17. 7 CFR 765.104-765.150 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false [Reserved] 765.104-765.150 Section 765.104-765.150 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS DIRECT LOAN SERVICING-REGULAR Borrower Graduation §§ 765.104-765.150 [Reserved] ...

  18. 7 CFR 765.104-765.150 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false [Reserved] 765.104-765.150 Section 765.104-765.150 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS DIRECT LOAN SERVICING-REGULAR Borrower Graduation §§ 765.104-765.150 [Reserved] ...

  19. 45 CFR 150.421 - Appearance of counsel.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Appearance of counsel. 150.421 Section 150.421 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.421 Appearance of counsel...

  20. 45 CFR 150.421 - Appearance of counsel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Appearance of counsel. 150.421 Section 150.421 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.421 Appearance of counsel...

  1. 45 CFR 150.449 - Cost of transcripts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Cost of transcripts. 150.449 Section 150.449 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.449 Cost of transcripts...

  2. Men presenting with prostate-specific antigen (PSA) values of over 100 ng/mL.

    PubMed

    Ang, Mann; Rajcic, Branimir; Foreman, Darren; Moretti, Kim; O'Callaghan, Michael E

    2016-04-01

    To investigate overall survival and prostate cancer-specific mortality in men with prostate cancer presenting with a PSA level <100 ng/mL at the time of diagnosis. Five-thousand seven hundred and sixteen patients with prostate cancer and a recorded diagnostic PSA level extracted from the South Australian Prostate Cancer Clinical Outcomes Collaborative (SA-PCCOC) database. Men included were diagnosed between January 1998 and August 2013. Patients were divided into groups according to diagnostic PSA level: <20, 20-≤100, 100-≤200 ng/mL, 200-≤500 ng/mL, and >500 ng/mL. Outcomes measured include overall survival and prostate cancer-specific mortality. Clinical stage, Gleason score and the presence of bony metastasis was evaluated to determine if they were prognostic factors in patients with PSA over 100 at diagnosis. Cox proportional hazards and competing risks regression were used to model overall survival and prostate cancer-specific mortality outcomes respectively. Of this cohort, 241 patients (4.2%) had a diagnostic PSA level >100 ng/mL. Patients with PSA >100 ng/mL have a significant reduction in five (29.1% vs 62.5% vs 87%) and ten-year (18.2% vs 36.7% vs 70.7%) overall survival when compared to men with diagnostic PSA 20-100 and <20 ng/mL respectively. In this group, prostate cancer-specific mortality was associated with Gleason score and metastases, but not PSA level at diagnosis. Overall survival was associated with PSA level, Gleason score and age. There was a linear increase in risk (overall survival) as PSA increased until 200 and no association thereafter. Models of overall survival and prostate cancer-specific mortality incorporating a risk stratification developed by Izumi et al. predicted overall survival but not prostate cancer-specific mortality. The use of this stratification did not improve model accuracy. Only a small number of men (4.2%) with prostate cancer present with PSA >100 ng/mL at diagnosis. Overall survival at five and ten

  3. 46 CFR 150.170 - Right of appeal.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Right of appeal. 150.170 Section 150.170 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.170 Right of appeal. Any person directly affected by a decision or action taken under this...

  4. 46 CFR 150.170 - Right of appeal.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Right of appeal. 150.170 Section 150.170 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.170 Right of appeal. Any person directly affected by a decision or action taken under this...

  5. 46 CFR 150.170 - Right of appeal.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Right of appeal. 150.170 Section 150.170 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.170 Right of appeal. Any person directly affected by a decision or action taken under this...

  6. 46 CFR 150.170 - Right of appeal.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Right of appeal. 150.170 Section 150.170 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.170 Right of appeal. Any person directly affected by a decision or action taken under this...

  7. 31 CFR 150.5 - Calculation of assessments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Calculation of assessments. 150.5 Section 150.5 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY FINANCIAL RESEARCH FUND § 150.5 Calculation of assessments. (a) For each assessed...

  8. 33 CFR 104.150 - Right to appeal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Right to appeal. 104.150 Section 104.150 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: VESSELS General § 104.150 Right to appeal. Any person directly affected by a decision or...

  9. 33 CFR 105.150 - Right to appeal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Right to appeal. 105.150 Section 105.150 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: FACILITIES General § 105.150 Right to appeal. Any person directly affected by a decision...

  10. 46 CFR 150.170 - Right of appeal.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Right of appeal. 150.170 Section 150.170 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.170 Right of appeal. Any person directly affected by a decision or action taken under this...

  11. 30 CFR 1202.150 - Royalty on gas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Royalty on gas. 1202.150 Section 1202.150 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE ROYALTIES Federal Gas § 1202.150 Royalty on gas. (a) Royalties due on gas production from leases...

  12. 30 CFR 1202.150 - Royalty on gas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Royalty on gas. 1202.150 Section 1202.150 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE ROYALTIES Federal Gas § 1202.150 Royalty on gas. (a) Royalties due on gas production from leases...

  13. 30 CFR 1202.150 - Royalty on gas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Royalty on gas. 1202.150 Section 1202.150 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE ROYALTIES Federal Gas § 1202.150 Royalty on gas. (a) Royalties due on gas production from leases...

  14. 30 CFR 1206.150 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Purpose and scope. 1206.150 Section 1206.150 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Federal Gas § 1206.150 Purpose and scope. (a) This subpart is applicable to all...

  15. 30 CFR 1206.150 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Purpose and scope. 1206.150 Section 1206.150 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Federal Gas § 1206.150 Purpose and scope. (a) This subpart is applicable to all...

  16. 30 CFR 1206.150 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Purpose and scope. 1206.150 Section 1206.150 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Federal Gas § 1206.150 Purpose and scope. (a) This subpart is applicable to all...

  17. 10 CFR 50.150 - Aircraft impact assessment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Aircraft impact assessment. 50.150 Section 50.150 Energy... Standards for Licenses, Certifications, and Regulatory Approvals § 50.150 Aircraft impact assessment. (a...-specific assessment of the effects on the facility of the impact of a large, commercial aircraft. Using...

  18. 45 CFR 150.419 - Forms of hearing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Forms of hearing. 150.419 Section 150.419 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.419 Forms of hearing. (a...

  19. 45 CFR 150.419 - Forms of hearing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Forms of hearing. 150.419 Section 150.419 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.419 Forms of hearing. (a...

  20. 7 CFR 1942.150 - OMB control number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true OMB control number. 1942.150 Section 1942.150... § 1942.150 OMB control number. The collection of information requirements in this regulation have been approved by the Office of Management and Budget and have been assigned OMB control number 0575-0120. ...

  1. 7 CFR 1942.150 - OMB control number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 13 2013-01-01 2013-01-01 false OMB control number. 1942.150 Section 1942.150... § 1942.150 OMB control number. The collection of information requirements in this regulation have been approved by the Office of Management and Budget and have been assigned OMB control number 0575-0120. ...

  2. 30 CFR 202.150 - Royalty on gas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Royalty on gas. 202.150 Section 202.150 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ROYALTIES Federal Gas § 202.150 Royalty on gas. (a) Royalties due on gas production from leases subject to the...

  3. Prostate-specific antigen 1.5-4.0 ng/mL: a diagnostic challenge and danger zone.

    PubMed

    Crawford, E David; Moul, Judd W; Rove, Kyle O; Pettaway, Curtis A; Lamerato, Lois E; Hughes, Alexa

    2011-12-01

    What's known on the subject? and What does the study add? Large population screening trials like the ERSPC, PCPT and PLCO have noted that men with seemingly low PSA (even as low as 0.5 ng/dL) still can have prostate cancer. Despite these findings, PSA is still predominantly used as a current indicator for possible presence of prostate cancer rather than also serving as a prognostic marker. This study examines a larger number of men in a diverse US population to determine the prognostic value of a man's baseline or first PSA. • To assess the value of a PSA threshold of 1.5 ng/mL as a predictor of increased prostate cancer risk over a four-year period based on a man's first PSA test, including racial differences. • To review the risk of progression of benign prostatic hyperplasia (BPH) based on a similar PSA threshold. • A retrospective review involving 21,502 men from a large Midwestern health system was performed. • Men at least 40 years old with baseline PSA values between 0 and 4.0 ng/mL and at least four years of follow-up after initial PSA test were included. • Optimal PSA threshold and predictive value of PSA for development of prostate cancer were calculated. • Prostate cancer rates were 15-fold higher in patients with PSA ≥1.5 ng/mL vs patients with PSA <1.5 ng/mL (7.85% vs 0.51%). • African American patients with baseline PSA <1.5 ng/mL faced prostate cancer rates similar to the whole study population (0.54% vs 0.51%, respectively), while African American patients with PSA 1.5-4.0 ng/mL faced a 19-fold increase in prostate cancer. • Both Caucasian and African American men with baseline PSA values between 1.5 and 4.0 ng/mL are at increased risk for future prostate cancer compared with those who have an initial PSA value below the 1.5 ng/mL threshold. • Based on a growing body of literature and this analysis, it is recommended that a first PSA test threshold of 1.5 ng/mL and above, or somewhere between 1.5 and 4.0 ng

  4. N.G. Basov and early works on semiconductor lasers at P.N. Lebedev Physics Institute

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Eliseev, P G

    2012-12-31

    A survey is presented of works on creation and investigation of semiconductor lasers during 1957 - 1977 at the P.N. Lebedev Physics Institute. Many of these works were initiated by N.G. Basov, starting from pre-laser time, when N.G. Basov and his coworkers formulated principal conditions of creation of lasers on interband transitions in semiconductors. Main directions of further works were diode lasers based on various materials and structures, their characteristics of output power, high-speed operation and reliability. (special issue devoted to the 90th anniversary of n.g. basov)

  5. Wave Energy Prize - 1/50th Testing - Iowec

    DOE Data Explorer

    Wesley Scharmen

    2015-12-18

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the Iowec team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  6. Wave Energy Prize - 1/50th Testing - SEWEC

    DOE Data Explorer

    Wesley Scharmen

    2015-12-11

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the SEWEC team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  7. Wave Energy Prize - 1/50th Testing - WECCA

    DOE Data Explorer

    Wesley Scharmen

    2016-01-15

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the WECCA team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  8. 32 CFR 150.17 - En banc proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false En banc proceedings. 150.17 Section 150.17... MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.17 En banc proceedings... reconsidered by the Court sitting as a whole. However, en banc reconsideration of an en banc decision will not...

  9. 32 CFR 150.17 - En banc proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false En banc proceedings. 150.17 Section 150.17... MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.17 En banc proceedings... reconsidered by the Court sitting as a whole. However, en banc reconsideration of an en banc decision will not...

  10. 21 CFR 160.150 - Frozen egg whites.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen egg whites. 160.150 Section 160.150 Food... HUMAN CONSUMPTION EGGS AND EGG PRODUCTS Requirements for Specific Standardized Eggs and Egg Products § 160.150 Frozen egg whites. (a) Frozen egg whites, frozen egg albumen is the food prepared by freezing...

  11. 32 CFR 150.17 - En banc proceedings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false En banc proceedings. 150.17 Section 150.17... MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.17 En banc proceedings... Article 66 extends to death. (2) In cases being reviewed pursuant to Article 66, a party's suggestion that...

  12. 32 CFR 150.17 - En banc proceedings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false En banc proceedings. 150.17 Section 150.17... MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.17 En banc proceedings... Article 66 extends to death. (2) In cases being reviewed pursuant to Article 66, a party's suggestion that...

  13. 32 CFR 150.17 - En banc proceedings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false En banc proceedings. 150.17 Section 150.17... MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.17 En banc proceedings... Article 66 extends to death. (2) In cases being reviewed pursuant to Article 66, a party's suggestion that...

  14. 21 CFR 160.150 - Frozen egg whites.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Frozen egg whites. 160.150 Section 160.150 Food... HUMAN CONSUMPTION EGGS AND EGG PRODUCTS Requirements for Specific Standardized Eggs and Egg Products § 160.150 Frozen egg whites. (a) Frozen egg whites, frozen egg albumen is the food prepared by freezing...

  15. Dirac quasiparticle tunneling in a NG/ferromagnetic barrier/SG graphene junction

    NASA Astrophysics Data System (ADS)

    Soodchomshom, Bumned; Tang, I.-Ming; Hoonsawat, Rassmidara

    2009-07-01

    We study the tunneling conductance in a spin dependent barrier NG/F B/SG graphene junction, where NG, F B and SG are normal graphene, gate ferromagnetic graphene barrier with thickness d and the graphene s-wave superconductor, respectively. In our work, the quasiparticle scattering process at the interfaces is based on quasi particles governed by the Dirac Bogoliubov-de Gennes equation with effective speed of light vF ∼ 10 6 m/s. The conductance of the junction is calculated based on Blonder-Tinkham-Klapwijk (BTK) formalism. The oscillatory conductance under varying gate potential and exchange energy in F B and the conductance induced by specular Andreev reflection are studied. By taking into account both effects of barrier strengths due to the gate potential χ∼Vd/ℏv and the exchange energy χ∼Ed/ℏv in the F B region, we find that the zero bias conductance of junction depends only on the ferromagnetic barrier strength χex in F B, when the Fermi energy in SG is very much larger than that the Fermi energy in NG ( EFS ≫ EFN). The oscillatory conductance peaks can be controlled by either varying χex or χG. In the limiting case, by setting Eex = 0, the conductance in a NG/N B/SG graphene junction, where SG is the s-wave superconductor, is also studied in order to compare with two earlier contradicted data. Our result agrees with what was obtained by Linder and Sudbo [J. Linder, A. Sudbo, Phys. Rev. B 77 (2008) 64507], which confirms the contradiction to what was given by Bhattacharjee and Sengupta [S. Bhattacharjee, K. Sengupta, Phys. Rev. Lett. 97 (2006) 217001].

  16. 32 CFR 150.1 - Name and seal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Name and seal. 150.1 Section 150.1 National... JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.1 Name and seal. (a) The titles... Court is authorized a seal in the discretion of the Judge Advocate General concerned. The design of such...

  17. 32 CFR 150.1 - Name and seal.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Name and seal. 150.1 Section 150.1 National... JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.1 Name and seal. (a) The titles... Court is authorized a seal in the discretion of the Judge Advocate General concerned. The design of such...

  18. 32 CFR 150.3 - Scope of review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.3 Scope of review. In cases referred to it for review pursuant to Article 66, the Court may act only with respect to the findings and... 32 National Defense 1 2010-07-01 2010-07-01 false Scope of review. 150.3 Section 150.3 National...

  19. 46 CFR 134.150 - Liftboat-jacking systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Liftboat-jacking systems. 134.150 Section 134.150... FOR LIFTBOATS § 134.150 Liftboat-jacking systems. (a) For this subchapter, liftboat jacking systems are vital systems and must comply with Sections 4/1.13.1 through 4/1.13.3 of the ABS's “Rules for...

  20. 46 CFR 134.150 - Liftboat-jacking systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Liftboat-jacking systems. 134.150 Section 134.150... FOR LIFTBOATS § 134.150 Liftboat-jacking systems. (a) For this subchapter, liftboat jacking systems are vital systems and must comply with Sections 4/1.13.1 through 4/1.13.3 of the ABS's “Rules for...

  1. 26 CFR 1.50B-4 - Partnerships.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Partnerships. 1.50B-4 Section 1.50B-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Rules for Computing Credit for Expenses of Work Incentive Programs § 1.50B-4 Partnerships. (a) General rule—(1) In general...

  2. Next Generation * Natural Gas (NG)2 Information Requirements--Executive Summary

    EIA Publications

    2000-01-01

    The Energy Information Administration (EIA) has initiated the Next Generation * Natural Gas (NG)2 project to design and implement a new and comprehensive information program for natural gas to meet customer requirements in the post-2000 time frame.

  3. Two-neutrino double-β decay of 150Nd to excited final states in 150Sm

    NASA Astrophysics Data System (ADS)

    Kidd, M. F.; Esterline, J. H.; Finch, S. W.; Tornow, W.

    2014-11-01

    Background: Double-β decay is a rare nuclear process in which two neutrons in the nucleus are converted to two protons with the emission of two electrons and two electron antineutrinos. Purpose: We measured the half-life of the two-neutrino double-β decay of 150Nd to excited final states of 150Sm by detecting the deexcitation γ rays of the daughter nucleus. Method: This study yields the first detection of the coincidence γ rays from the 0 1+ excited state of 150Sm. These γ rays have energies of 333.97 and 406.52 keV and are emitted in coincidence through a 01+→21+→0gs+ transition. Results: The enriched Nd2O3 sample consisted of 40.13 g 150Nd and was observed for 642.8 days at the Kimballton Underground Research Facility, producing 21.6 net events in the region of interest. This count rate gives a half-life of T1 /2=[1 .07-0.25+0.45(stat ) ±0.07 (syst ) ] ×1020 yr. The effective nuclear matrix element was found to be 0.0465 -0.0054+0.0098. Finally, lower limits were obtained for decays to higher excited final states. Conclusions: Our half-life measurement agrees within uncertainties with another recent measurement in which no coincidence was employed. Our nuclear matrix element calculation may have an impact on a recent neutrinoless double-β decay nuclear matrix element calculation which implies that the decay to the first excited state in 150Sm is favored over that to the ground state.

  4. Power budget enhancement in NG-EPON system employing novel twisted-PAM4

    NASA Astrophysics Data System (ADS)

    Li, Longsheng; Bi, Meihua; Fu, Yan; Miao, Xin; Zhu, Qingming; Hu, Weisheng

    2018-03-01

    In this paper, we firstly design a novel modulation format named Twisted-PAM4 (T-PAM4) for the high-speed NG-EPON and the PON-based digital fronthaul system. Compared to other high-order modulation formats like 4-ary pulse amplitude modulation (PAM4), T-PAM4 provides two independent sampling values in each symbol period and enables two-dimensional symbol decision, which significantly improves the receiver sensitivity and hence enlarges the system power budget. Based on this advantage, six types of T-PAM4 are experimentally demonstrated in 28-Gb/s/ λ NG-PON and 32-Gb/s/ λ PON-based digital fronthaul system. The experimental results show that, compared to the ordinary PAM4, the T-PAM4 can bring 5-dB and 4-dB extra power budget in NG-EPON and PON-based fronthaul system respectively. In addition, by experiment, it is also depicted that the T-PAM4 is remarkably robust to system nonlinearity, which would ease the linearity requirement on system components and hence reduce system cost.

  5. 32 CFR Appendix B to Part 150 - Format for Assignment of Errors and Brief on Behalf of Accused (§ 150.15)

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Format for Assignment of Errors and Brief on Behalf of Accused (§ 150.15) B Appendix B to Part 150 National Defense Department of Defense OFFICE OF... OF PRACTICE AND PROCEDURE Pt. 150, App. B Appendix B to Part 150—Format for Assignment of Errors and...

  6. 32 CFR Appendix B to Part 150 - Format for Assignment of Errors and Brief on Behalf of Accused (§ 150.15)

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Format for Assignment of Errors and Brief on Behalf of Accused (§ 150.15) B Appendix B to Part 150 National Defense Department of Defense OFFICE OF... OF PRACTICE AND PROCEDURE Pt. 150, App. B Appendix B to Part 150—Format for Assignment of Errors and...

  7. Glial kon/NG2 gene network for central nervous system repair.

    PubMed

    Losada-Perez, Maria; Harrison, Neale; Hidalgo, Alicia

    2017-01-01

    The glial regenerative response to central nervous system (CNS) injury, although limited, can be harnessed to promote regeneration and repair. Injury provokes the proliferation of ensheathing glial cells, which can differentiate to remyelinate axons, and partially restore function. This response is evolutionarily conserved, strongly implying an underlying genetic mechanism. In mammals, it is elicited by NG2 glia, but most often newly generated cells fail to differentiate. Thus an important goal had been to find out how to promote glial differentiation following the proliferative response. A gene network involving Notch and prospero (pros) controls the balance between glial proliferation and differentiation in flies and mice, and promotes CNS repair at least in fruit-flies. A key missing link had been how to relate the function of NG2 to this gene network. Recent findings by Losada-Perez et al., published in JCB, demonstrated that the Drosophila NG2 homologue kon-tiki (kon) is functionally linked to Notch and pros in glia. By engaging in two feedback loops with Notch and Pros, in response to injury, Kon can regulate both glial cell number and glial shape homeostasis, essential for repair. Drosophila offers powerful genetics to unravel the control of stem and progenitor cells for regeneration and repair.

  8. 40 CFR 1065.150 - Continuous sampling.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Continuous sampling. 1065.150 Section... ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use continuous sampling techniques for measurements that involve raw or dilute sampling. Make sure continuous sampling...

  9. 40 CFR 1065.150 - Continuous sampling.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Continuous sampling. 1065.150 Section... ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use continuous sampling techniques for measurements that involve raw or dilute sampling. Make sure continuous sampling...

  10. 45 CFR 205.150 - Cost allocation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Cost allocation. 205.150 Section 205.150 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION-PUBLIC...

  11. 45 CFR 205.150 - Cost allocation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Cost allocation. 205.150 Section 205.150 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION-PUBLIC...

  12. 45 CFR 205.150 - Cost allocation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Cost allocation. 205.150 Section 205.150 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION-PUBLIC...

  13. 45 CFR 205.150 - Cost allocation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Cost allocation. 205.150 Section 205.150 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION-PUBLIC...

  14. 45 CFR 150.201 - State enforcement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false State enforcement. 150.201 Section 150.201 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS CMS Enforcement Processes for Determining Whether States...

  15. Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses.

    PubMed

    Rissanen, Ilona; Ahmed, Asim A; Azarm, Kristopher; Beaty, Shannon; Hong, Patrick; Nambulli, Sham; Duprex, W Paul; Lee, Benhur; Bowden, Thomas A

    2017-07-12

    In 2012, cases of lethal pneumonia among Chinese miners prompted the isolation of a rat-borne henipavirus (HNV), Mòjiāng virus (MojV). Although MojV is genetically related to highly pathogenic bat-borne henipaviruses, the absence of a conserved ephrin receptor-binding motif in the MojV attachment glycoprotein (MojV-G) indicates a differing host-cell recognition mechanism. Here we find that MojV-G displays a six-bladed β-propeller fold bearing limited similarity to known paramyxoviral attachment glycoproteins, in particular at host receptor-binding surfaces. We confirm the inability of MojV-G to interact with known paramyxoviral receptors in vitro, indicating an independence from well-characterized ephrinB2/B3, sialic acid and CD150-mediated entry pathways. Furthermore, we find that MojV-G is antigenically distinct, indicating that MojV would less likely be detected in existing large-scale serological screening studies focused on well-established HNVs. Altogether, these data indicate a unique host-cell entry pathway for this emerging and potentially pathogenic HNV.

  16. 26 CFR 1.50A-4 - Exceptions to the application of § 1.50A-3.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... paragraph (a) of § 1.50A-3 if it is determined by the appropriate State administrative agency or State court... compensation), he could reasonably have been found by such administrative agency or court to have been... comparable wages to such employee (within the meaning of paragraph (a)(2) of § 1.50A-3), then paragraph (a)(3...

  17. 21 CFR 169.150 - Salad dressing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Salad dressing. 169.150 Section 169.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION FOOD DRESSINGS AND FLAVORINGS Requirements for Specific Standardized Food Dressings and Flavorings...

  18. 37 CFR 150.6 - Mailing address.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Mailing address. 150.6 Section 150.6 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE PROTECTION OF FOREIGN MASK WORKS REQUESTS FOR PRESIDENTIAL PROCLAMATIONS PURSUANT TO 17 U.S.C. 902...

  19. 41 CFR 105-71.150 - Closeout.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Closeout. 105-71.150 Section 105-71.150 Public Contracts and Property Management Federal Property Management Regulations System... grantee must submit all financial, performance, and other reports required as a condition of the grant...

  20. 45 CFR 205.150 - Cost allocation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Cost allocation. 205.150 Section 205.150 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS... Social Security Act must provide that the State agency will have an approved cost allocation plan on file...

  1. 21 CFR 169.150 - Salad dressing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Salad dressing. 169.150 Section 169.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION FOOD DRESSINGS AND FLAVORINGS Requirements for Specific Standardized Food Dressings and Flavorings...

  2. 38 CFR 17.150 - Prosthetic and similar appliances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... appliances. 17.150 Section 17.150 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Prosthetic, Sensory, and Rehabilitative Aids § 17.150 Prosthetic and similar appliances... appliances including invalid lifts and therapeutic and rehabilitative devices, and special clothing made...

  3. Test Report for NG Sensors GTX-1000

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Manginell, Ronald P.

    2014-12-01

    This report describes initial testing of the NG Sensor GTX-1000 natural gas monitoring system. This testing showed that the retention time, peak area stability and heating value repeatability of the GTX-1000 were promising for natural gas measurements in the field or at the well head. The repeatability can be less than 0.25% for LHV and HHV for the Airgas standard tested in this report, which is very promising for a first generation prototype. Ultimately this system should be capable of 0.1% repeatability in heating value at significant size and power reductions compared with competing systems.

  4. SIMPL/AVIRIS-NG Greenland 2015: Flight Report

    NASA Technical Reports Server (NTRS)

    Brunt, Kelly M.; Neumann, Thomas A.; Markus, Thorsten

    2015-01-01

    In August 2015, NASA conducted a two-­aircraft, coordinated campaign based out of Thule Air Base, Greenland, in support of Ice, Cloud, and land Elevation Satellite-2 (ICESat-2) algorithm development. The survey targeted the Greenland Ice Sheet and sea ice in the Arctic Ocean during the summer melt season. The survey was conducted with a photon-counting laser altimeter in one aircraft and an imaging spectrometer in the second aircraft. Ultimately, the mission, SIMPL/AVIRIS-NG Greenland 2015, conducted nine coordinated science flights, for a total of 37 flight hours over the ice sheet and sea ice.

  5. Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord.

    PubMed

    Keirstead, H S; Levine, J M; Blakemore, W F

    1998-02-01

    Elucidation of the response of oligodendrocyte progenitor cell populations to demyelination in the adult central nervous system (CNS) is critical to understanding why remyelination fails in multiple sclerosis. Using the anti-NG2 monoclonal antibody to identify oligodendrocyte progenitor cells, we have documented their response to antibody-induced demyelination in the dorsal column of the adult rat spinal cord. The number of NG2+ cells in the vicinity of demyelinated lesions increased by 72% over the course of 3 days following the onset of demyelination. This increase in NG2+ cell numbers did not reflect a nonspecific staining of reactive cells, as GFAP, OX-42, and Rip antibodies did not co-localise with NG2 + cells in double immunostained tissue sections. NG2 + cells incorporated BrdU 48-72 h following the onset of demyelination. After the onset of remyelination (10-14 days), the number of NG2+ cells decreased to 46% of control levels and remained consistently low for 2 months. When spinal cords were exposed to 40 Grays of x-irradiation prior to demyelination, the number of NG2+ cells decreased to 48% of control levels by 3 days following the onset of demyelination and remained unchanged at 3 weeks. Since 40 Grays of x-irradiation kills dividing cells, these studies illustrate a responsive and nonresponsive NG2+ cell population following demyelination in the adult spinal cord and suggest that the responsive NG2+ cell population does not renew itself.

  6. 21 CFR 164.150 - Peanut butter.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Peanut butter. 164.150 Section 164.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION TREE NUT AND PEANUT PRODUCTS Requirements for Specific Standardized Tree Nut and Peanut Products...

  7. 21 CFR 164.150 - Peanut butter.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Peanut butter. 164.150 Section 164.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION TREE NUT AND PEANUT PRODUCTS Requirements for Specific Standardized Tree Nut and Peanut Products...

  8. 21 CFR 164.150 - Peanut butter.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Peanut butter. 164.150 Section 164.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION TREE NUT AND PEANUT PRODUCTS Requirements for Specific Standardized Tree Nut and Peanut Products...

  9. 21 CFR 164.150 - Peanut butter.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Peanut butter. 164.150 Section 164.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION TREE NUT AND PEANUT PRODUCTS Requirements for Specific Standardized Tree Nut and Peanut Products...

  10. 29 CFR 1926.150 - Fire protection.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... Modification of sprinkler systems to permit alterations or additional demolition should be expedited so that... each floor. (e) Fire alarm devices. (1) An alarm system, e.g., telephone system, siren, etc., shall be... 29 Labor 8 2014-07-01 2014-07-01 false Fire protection. 1926.150 Section 1926.150 Labor...

  11. 29 CFR 1926.150 - Fire protection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... Modification of sprinkler systems to permit alterations or additional demolition should be expedited so that... each floor. (e) Fire alarm devices. (1) An alarm system, e.g., telephone system, siren, etc., shall be... 29 Labor 8 2011-07-01 2011-07-01 false Fire protection. 1926.150 Section 1926.150 Labor...

  12. 29 CFR 1926.150 - Fire protection.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... Modification of sprinkler systems to permit alterations or additional demolition should be expedited so that... each floor. (e) Fire alarm devices. (1) An alarm system, e.g., telephone system, siren, etc., shall be... 29 Labor 8 2013-07-01 2013-07-01 false Fire protection. 1926.150 Section 1926.150 Labor...

  13. 29 CFR 1926.150 - Fire protection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... Modification of sprinkler systems to permit alterations or additional demolition should be expedited so that... each floor. (e) Fire alarm devices. (1) An alarm system, e.g., telephone system, siren, etc., shall be... 29 Labor 8 2012-07-01 2012-07-01 false Fire protection. 1926.150 Section 1926.150 Labor...

  14. 22 CFR 711.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....150 Section 711.150 Foreign Relations OVERSEAS PRIVATE INVESTMENT CORPORATION ADMINISTRATIVE... THE OVERSEAS PRIVATE INVESTMENT CORPORATION § 711.150 Program accessibility: Existing facilities. (a... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

  15. NG2/CSPG4-collagen type VI interplays putatively involved in the microenvironmental control of tumour engraftment and local expansion.

    PubMed

    Cattaruzza, Sabrina; Nicolosi, Pier Andrea; Braghetta, Paola; Pazzaglia, Laura; Benassi, Maria Serena; Picci, Piero; Lacrima, Katia; Zanocco, Daniela; Rizzo, Erika; Stallcup, William B; Colombatti, Alfonso; Perris, Roberto

    2013-06-01

    In soft-tissue sarcoma patients, enhanced expression of NG2/CSPG4 proteoglycan in pre-surgical primary tumours predicts post-surgical metastasis formation and thereby stratifies patients into disease-free survivors and patients destined to succumb to the disease. Both primary and secondary sarcoma lesions also up-regulate collagen type VI, a putative extracellular matrix ligand of NG2, and this matrix alteration potentiates the prognostic impact of NG2. Enhanced constitutive levels of the proteoglycan in isolated sarcoma cells closely correlate with a superior engraftment capability and local growth in xenogenic settings. This apparent NG2-associated malignancy was also corroborated by the diverse tumorigenic behaviour in vitro and in vivo of immunoselected NG2-expressing and NG2-deficient cell subsets, by RNAi-mediated knock down of endogenous NG2, and by ectopic transduction of full-length or deletion constructs of NG2. Cells with modified expression of NG2 diverged in their interaction with purified Col VI, matrices supplemented with Col VI, and cell-free matrices isolated from wild-type and Col VI null fibroblasts. The combined use of dominant-negative NG2 mutant cells and purified domain fragments of the collagen allowed us to pinpoint the reciprocal binding sites within the two molecules and to assert the importance of this molecular interaction in the control of sarcoma cell adhesion and motility. The NG2-mediated binding to Col VI triggered activation of convergent cell survival- and cell adhesion/migration-promoting signal transduction pathways, implicating PI-3K as a common denominator. Thus, the findings point to an NG2-Col VI interplay as putatively involved in the regulation of the cancer cell-host microenvironment interactions sustaining sarcoma progression.

  16. 21 CFR 139.150 - Noodle products.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Noodle products. 139.150 Section 139.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... seasons the food. (3) Gum gluten, in such quantity that the protein derived therefrom, together with the...

  17. 21 CFR 139.150 - Noodle products.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Noodle products. 139.150 Section 139.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... seasons the food. (3) Gum gluten, in such quantity that the protein derived therefrom, together with the...

  18. 21 CFR 139.150 - Noodle products.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Noodle products. 139.150 Section 139.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... seasons the food. (3) Gum gluten, in such quantity that the protein derived therefrom, together with the...

  19. 21 CFR 139.150 - Noodle products.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Noodle products. 139.150 Section 139.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... seasons the food. (3) Gum gluten, in such quantity that the protein derived therefrom, together with the...

  20. 21 CFR 131.150 - Heavy cream.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... concentrated fruit and fruit juice). (ii) Natural and artificial food flavoring. (c) Methods of analysis. The... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Heavy cream. 131.150 Section 131.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

  1. 21 CFR 131.150 - Heavy cream.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... concentrated fruit and fruit juice). (ii) Natural and artificial food flavoring. (c) Methods of analysis. The... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Heavy cream. 131.150 Section 131.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

  2. 21 CFR 131.150 - Heavy cream.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... concentrated fruit and fruit juice). (ii) Natural and artificial food flavoring. (c) Methods of analysis. The... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Heavy cream. 131.150 Section 131.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

  3. 21 CFR 131.150 - Heavy cream.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... concentrated fruit and fruit juice). (ii) Natural and artificial food flavoring. (c) Methods of analysis. The... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Heavy cream. 131.150 Section 131.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

  4. 21 CFR 131.150 - Heavy cream.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... concentrated fruit and fruit juice). (ii) Natural and artificial food flavoring. (c) Methods of analysis. The... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Heavy cream. 131.150 Section 131.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

  5. 44 CFR 16.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Program accessibility: Existing facilities. 16.150 Section 16.150 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE FEDERAL EMERGENCY MANAGEMENT AGENCY § 16.150 Program...

  6. 19 CFR 201.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Program accessibility: Existing facilities. 201.150 Section 201.150 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF... Conducted by the U.S. International Trade Commission § 201.150 Program accessibility: Existing facilities...

  7. 19 CFR 201.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Program accessibility: Existing facilities. 201.150 Section 201.150 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF... Conducted by the U.S. International Trade Commission § 201.150 Program accessibility: Existing facilities...

  8. 19 CFR 201.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Program accessibility: Existing facilities. 201.150 Section 201.150 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF... Conducted by the U.S. International Trade Commission § 201.150 Program accessibility: Existing facilities...

  9. 19 CFR 201.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Program accessibility: Existing facilities. 201.150 Section 201.150 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF... Conducted by the U.S. International Trade Commission § 201.150 Program accessibility: Existing facilities...

  10. 19 CFR 201.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Program accessibility: Existing facilities. 201.150 Section 201.150 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF... Conducted by the U.S. International Trade Commission § 201.150 Program accessibility: Existing facilities...

  11. 5 CFR 1636.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... facilities. 1636.150 Section 1636.150 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD... RETIREMENT THRIFT INVESTMENT BOARD § 1636.150 Program accessibility: Existing facilities. (a) General. The... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

  12. 45 CFR 2490.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Program accessibility: Existing facilities. 2490.150 Section 2490.150 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON... ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.150 Program accessibility...

  13. 45 CFR 2490.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Program accessibility: Existing facilities. 2490.150 Section 2490.150 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON... ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.150 Program accessibility...

  14. 45 CFR 2490.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Program accessibility: Existing facilities. 2490.150 Section 2490.150 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON... ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.150 Program accessibility...

  15. 45 CFR 2490.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Program accessibility: Existing facilities. 2490.150 Section 2490.150 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON... ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.150 Program accessibility...

  16. 13 CFR 107.150 - Management-ownership diversity requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Management-ownership diversity requirement. 107.150 Section 107.150 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Qualifying for an SBIC License Organizing An Sbic § 107.150 Management...

  17. 13 CFR 107.150 - Management-ownership diversity requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Management-ownership diversity requirement. 107.150 Section 107.150 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Qualifying for an SBIC License Organizing An Sbic § 107.150 Management...

  18. 45 CFR 2301.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Program accessibility: Existing facilities. 2301.150 Section 2301.150 Public Welfare Regulations Relating to Public Welfare (Continued) ARCTIC RESEARCH... THE UNITED STATES ARCTIC RESEARCH COMMISSION § 2301.150 Program accessibility: Existing facilities. (a...

  19. 45 CFR 2301.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Program accessibility: Existing facilities. 2301.150 Section 2301.150 Public Welfare Regulations Relating to Public Welfare (Continued) ARCTIC RESEARCH... THE UNITED STATES ARCTIC RESEARCH COMMISSION § 2301.150 Program accessibility: Existing facilities. (a...

  20. 5 CFR 723.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... facilities. 723.150 Section 723.150 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL... ACTIVITIES CONDUCTED BY THE OFFICE OF PERSONNEL MANAGEMENT § 723.150 Program accessibility: Existing... would result in a fundamental alteration in the nature of a program or activity or in undue financial...

  1. 10 CFR 1041.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Program accessibility: Existing facilities. 1041.150 Section 1041.150 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF ENERGY § 1041.150 Program...

  2. 10 CFR 1041.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Program accessibility: Existing facilities. 1041.150 Section 1041.150 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF ENERGY § 1041.150 Program...

  3. 10 CFR 1041.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Program accessibility: Existing facilities. 1041.150 Section 1041.150 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF ENERGY § 1041.150 Program...

  4. 10 CFR 1041.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Program accessibility: Existing facilities. 1041.150 Section 1041.150 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF ENERGY § 1041.150 Program...

  5. 10 CFR 1041.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Program accessibility: Existing facilities. 1041.150 Section 1041.150 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF ENERGY § 1041.150 Program...

  6. 45 CFR 150.423 - Communications with the ALJ.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Communications with the ALJ. 150.423 Section 150.423 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.423...

  7. 5 CFR 1207.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... facilities. 1207.150 Section 1207.150 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION... CONDUCTED BY THE MERIT SYSTEMS PROTECTION BOARD § 1207.150 Program accessibility: Existing facilities. (a) General. The agency shall operate each program or activity so that the program or activity, when viewed in...

  8. 33 CFR 150.612 - What footwear is required?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What footwear is required? 150.612 Section 150.612 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Feet § 150.612 What...

  9. 41 CFR 105-53.150 - Organization and functions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Organization and functions. 105-53.150 Section 105-53.150 Public Contracts and Property Management Federal Property... FUNCTIONS Regional Offices § 105-53.150 Organization and functions. Regional offices have been established...

  10. 31 CFR 150.4 - Calculation of assessment basis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Calculation of assessment basis. 150.4 Section 150.4 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY FINANCIAL RESEARCH FUND § 150.4 Calculation of assessment basis. (a...

  11. 31 CFR 150.3 - Determination of assessed companies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Determination of assessed companies. 150.3 Section 150.3 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY FINANCIAL RESEARCH FUND § 150.3 Determination of assessed companies...

  12. Wave Energy Prize - 1/50th Testing - Waveswing America

    DOE Data Explorer

    Wesley Scharmen

    2016-01-22

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the Waveswing America team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents Results

  13. 21 CFR 164.150 - Peanut butter.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... food additives as defined in section 201(s) of the Federal Food, Drug, and Cosmetic Act (the act), or if they are food additives as so defined, they are used in conformity with regulations established... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Peanut butter. 164.150 Section 164.150 Food and...

  14. Wave Energy Prize - 1/50th Testing - Oscilla Power

    DOE Data Explorer

    Wesley Scharmen

    2016-01-08

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the Oscilla Power team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  15. Wave Energy Prize - 1/50th Testing - Principle Power

    DOE Data Explorer

    Wesley Scharmen

    2016-01-08

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the Principle Power team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  16. Wave Energy Prize - 1/50th Testing - Sea Potential

    DOE Data Explorer

    Wesley Scharmen

    2015-12-04

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the Sea Potential team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  17. Wave Energy Prize - 1/50th Testing - Mocean Energy

    DOE Data Explorer

    Wesley Scharmen

    2016-01-08

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the Mocean Energy team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  18. Wave Energy Prize - 1/50th Testing - CalWave

    DOE Data Explorer

    Wesley Scharmen

    2016-01-15

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the CalWave team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  19. Wave Energy Prize - 1/50th Testing - AquaHarmonics

    DOE Data Explorer

    Wesley Scharmen

    2016-01-15

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the AquaHarmonics team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  20. 10 CFR 455.150 - Right to administrative review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Right to administrative review. 455.150 Section 455.150 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION GRANT PROGRAMS FOR SCHOOLS AND HOSPITALS AND BUILDINGS OWNED BY UNITS OF LOCAL GOVERNMENT AND PUBLIC CARE INSTITUTIONS Administrative Review § 455.150 Right to...

  1. 45 CFR 150.307 - Notice to responsible entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Notice to responsible entities. 150.307 Section... and Non-Federal Governmental Plans-Civil Money Penalties § 150.307 Notice to responsible entities. If... responsible entity or entities identified under § 150.305. The notice does the following: (a) Describes the...

  2. 45 CFR 150.307 - Notice to responsible entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Notice to responsible entities. 150.307 Section... and Non-Federal Governmental Plans-Civil Money Penalties § 150.307 Notice to responsible entities. If... responsible entity or entities identified under § 150.305. The notice does the following: (a) Describes the...

  3. 45 CFR 150.403 - Scope of ALJ's authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Scope of ALJ's authority. 150.403 Section 150.403 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.403 Scope of ALJ's...

  4. 45 CFR 150.403 - Scope of ALJ's authority.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Scope of ALJ's authority. 150.403 Section 150.403 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.403 Scope of ALJ's...

  5. 45 CFR 150.461 - Failure to pay assessment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Failure to pay assessment. 150.461 Section 150.461 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.461 Failure to pay...

  6. 45 CFR 150.461 - Failure to pay assessment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Failure to pay assessment. 150.461 Section 150.461 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.461 Failure to pay...

  7. 45 CFR 150.461 - Failure to pay assessment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Failure to pay assessment. 150.461 Section 150.461 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.461 Failure to pay...

  8. 45 CFR 150.461 - Failure to pay assessment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Failure to pay assessment. 150.461 Section 150.461 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.461 Failure to pay...

  9. 33 CFR 150.521 - What records are required?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What records are required? 150.521 Section 150.521 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Equipment § 150.521 What records are required? (a) The operator must maintain a record of each test and...

  10. 32 CFR 150.5 - Place for filing papers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Place for filing papers. 150.5 Section 150.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.5 Place for filing papers...

  11. 32 CFR 150.5 - Place for filing papers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Place for filing papers. 150.5 Section 150.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.5 Place for filing papers...

  12. 32 CFR 150.5 - Place for filing papers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Place for filing papers. 150.5 Section 150.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.5 Place for filing papers...

  13. 32 CFR 150.5 - Place for filing papers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Place for filing papers. 150.5 Section 150.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.5 Place for filing papers...

  14. 32 CFR 150.5 - Place for filing papers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Place for filing papers. 150.5 Section 150.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.5 Place for filing papers...

  15. 21 CFR 1314.150 - Order To show cause.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Order To show cause. 1314.150 Section 1314.150 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE RETAIL SALE OF SCHEDULED LISTED CHEMICAL PRODUCTS Order to Show Cause § 1314.150 Order To show cause. (a) If, upon information gathered by...

  16. 45 CFR 150.461 - Failure to pay assessment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Failure to pay assessment. 150.461 Section 150.461... ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.461 Failure to pay assessment. If any entity fails to pay an assessment after it becomes a final order, or after the court has...

  17. The expression of '150-kDa oxygen regulated protein (ORP-150)' in human brain and its relationship with duration time until death.

    PubMed

    Ikematsu, Kazuya; Tsuda, Ryouichi; Kondo, Toshikazu; Kondo, Hisayoshi; Ozawa, Kentaro; Ogawa, Satoshi; Nakasono, Ichiro

    2004-04-01

    The expression of oxygen regulated protein 150-kDa (ORP-150) was strongly induced in human brain under the hypoxic conditions. We examined the expression of ORP-150 in the brain samples, and discussed its significance in forensic practice. The cerebral cortexes of 31 cases (asphyxia: 9 cases, hypothermia: 4, exsanguinations: 5, CO intoxication (CO): 6, sudden cardiac death (SCD): 7) were used for this study. Each tissue section was incubated with anti-ORP-150 polyclonal antibody and the number of ORP-150 positive cells were counted. In the multiple linear regression method, the estimated regression coefficient of ORP-150 on age was significant (P=0.039) thus, we could find that the ORP-150 expression level depended on age. Using analysis of covariance, we compared the means of ORP-150, LSMEAN, which means hypothetic average value excluding influence of age, for each cause of death. The LSMEAN+/-SE was 84.74+/-9.03 in hypothermia, 57.52+/-6.34 in asphyxia, 46.68+/-6.70 in CO, 24.84+/-8.05 in exsanguinations, and 16.24+/-7.35 in SCD. As a result of the analysis, the LSMEAN of the ORP-150 expression level was related to the cause of death. There might be differences in the duration of brain ischemia before death. For example, SCD is presumed to be instant death, while brain ischemia continues for several minutes in asphyxia, CO and exsanguinations, and for several hours in hypothermia cases. Therefore, the immunohistochemical and morphometrical analysis of ORP-150 in the brain may be very useful to determine the duration of brain ischemia before death in forensic autopsy cases.

  18. Mineral Potential in India Using Airborne Visible/Infrared Imaging Spectrometer-Next Generation (AVIRIS-NG) Data

    NASA Astrophysics Data System (ADS)

    Oommen, T.; Chatterjee, S.

    2017-12-01

    NASA and the Indian Space Research Organization (ISRO) are generating Earth surface features data using Airborne Visible/Infrared Imaging Spectrometer-Next Generation (AVIRIS-NG) within 380 to 2500 nm spectral range. This research focuses on the utilization of such data to better understand the mineral potential in India and to demonstrate the application of spectral data in rock type discrimination and mapping for mineral exploration by using automated mapping techniques. The primary focus area of this research is the Hutti-Maski greenstone belt, located in Karnataka, India. The AVIRIS-NG data was integrated with field analyzed data (laboratory scaled compositional analysis, mineralogy, and spectral library) to characterize minerals and rock types. An expert system was developed to produce mineral maps from AVIRIS-NG data automatically. The ground truth data from the study areas was obtained from the existing literature and collaborators from India. The Bayesian spectral unmixing algorithm was used in AVIRIS-NG data for endmember selection. The classification maps of the minerals and rock types were developed using support vector machine algorithm. The ground truth data was used to verify the mineral maps.

  19. Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng).

    PubMed

    Lee, Kuo-Hsiung; Morris-Natschke, Susan; Qian, Keduo; Dong, Yizhou; Yang, Xiaoming; Zhou, Ting; Belding, Eileen; Wu, Shou-Fang; Wada, Koji; Akiyama, Toshiyuki

    2012-01-01

    This article will review selected herbal products from Chinese Materia Medica that are used in Traditional Chinese Medicine. The herbs come from the upper, middle, and lower class medicines as listed in The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng). The review will focus on the active constituents of the herbs and their bioactivities, with emphasis on the most recent progress in research for the period of 2003 to 2011.

  20. 42 CFR 441.150 - Basis and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Basis and purpose. 441.150 Section 441.150 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... 1905 (a)(16) and (h) of the Act. ...

  1. 42 CFR 441.150 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Basis and purpose. 441.150 Section 441.150 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... 1905 (a)(16) and (h) of the Act. ...

  2. 26 CFR 1.50B-3 - Estates and trusts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Estates and trusts. 1.50B-3 Section 1.50B-3... Computing Credit for Expenses of Work Incentive Programs § 1.50B-3 Estates and trusts. (a) General rule—(1) In general. In the case of an estate or trust, WIN expenses (as defined in paragraph (a) of § 1.50B-1...

  3. 33 CFR 80.150 - Block Island, RI.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Block Island, RI. 80.150 Section... NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.150 Block Island, RI. The 72 COLREGS shall apply on the harbors of Block Island. ...

  4. 7 CFR 3015.150 - Scope and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Scope and applicability. 3015.150 Section 3015.150 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Application for Federal Assistance § 3015...

  5. 37 CFR 150.5 - Duration of proclamation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Duration of proclamation. 150.5 Section 150.5 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE PROTECTION OF FOREIGN MASK WORKS REQUESTS FOR PRESIDENTIAL PROCLAMATIONS PURSUANT TO...

  6. 37 CFR 150.2 - Initiation of evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Initiation of evaluation. 150.2 Section 150.2 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE PROTECTION OF FOREIGN MASK WORKS REQUESTS FOR PRESIDENTIAL PROCLAMATIONS PURSUANT TO...

  7. 50 CFR 600.150 - Disposition of records.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Disposition of records. 600.150 Section 600.150 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

  8. 50 CFR 600.150 - Disposition of records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Disposition of records. 600.150 Section 600.150 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

  9. 50 CFR 600.150 - Disposition of records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Disposition of records. 600.150 Section 600.150 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

  10. Prostate health index significantly reduced unnecessary prostate biopsies in patients with PSA 2-10 ng/mL and PSA >10 ng/mL: Results from a Multicenter Study in China.

    PubMed

    Na, Rong; Ye, Dingwei; Qi, Jun; Liu, Fang; Helfand, Brian T; Brendler, Charles B; Conran, Carly A; Packiam, Vignesh; Gong, Jian; Wu, Yishuo; Zheng, Siqun L; Mo, Zengnan; Ding, Qiang; Sun, Yinghao; Xu, Jianfeng

    2017-08-01

    The performance of prostate health index (phi) in predicting prostate biopsy outcomes has been well established for patients with prostate-specific antigen (PSA) values between 2 and 10 ng/mL. However, the performance of phi remains unknown in patients with PSA >10 ng/mL, the vast majority in Chinese biopsy patients. We aimed to assess the ability of phi to predict prostate cancer (PCa) and high-grade disease (Gleason Score ≥7) on biopsy in a Chinese population. This is a prospective, observational, multi-center study of consecutive patients who underwent a transrectal ultrasound guided prostate biopsy at four hospitals in Shanghai, China from August 2013 to December 2014. In the cohort of 1538 patients, the detection rate of PCa was 40.2%. phi had a significantly better predictive performance for PCa than total PSA (tPSA). The areas under the receiver operating characteristic curve (AUC) were 0.90 and 0.79 for phi and tPSA, respectively, P < 0.0001. A considerable proportion of patients in the cohort had PSAs >10 ng/mL (N = 838, 54.5%). The detection rates of PCa were 35.9% and 57.7% in patients with tPSA 10.1-20 and 20.1-50 ng/mL, respectively. The AUCs of phi (0.79 and 0.89, for these two groups, respectively) were also significantly higher than tPSA (0.57 and 0.63, respectively), both P < 0.0001. If a phi ≤35 was used as the cutoff, 599/1538 (39%) biopsies could have been avoided at a cost of missing small numbers of PCa patients: 49 (7.93%) PCa patients, including 18 (3.69%) high-grade tumors. Results from this study suggest that phi can be used to predict PCa and high-grade disease in Chinese men with high PSA levels (>10 ng/mL). © 2017 Wiley Periodicals, Inc.

  11. Wave Energy Prize - 1/50th Testing - Float Inc

    DOE Data Explorer

    Wesley Scharmen

    2016-01-15

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for Float Inc. During the testing of its 1/50th-scale device, Float Inc. Berger ABAM was deemed ineligible due to the fact that they brought a device with them to test and did not ship the device by the deadline stipulated in the Wave Energy Prize Rules. Because of this, analysis, results, and judging were not completed for this team/device. This submission included files such as: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents

  12. Photonic integrated transmitter and receiver for NG-PON2

    NASA Astrophysics Data System (ADS)

    Tavares, Ana; Lopes, Ana; Rodrigues, Cláudio; Mãocheia, Paulo; Mendes, Tiago; Brandão, Simão.; Rodrigues, Francisco; Ferreira, Ricardo; Teixeira, António

    2014-08-01

    In this paper the authors present a monolithic Photonic Integrated Circuit which includes a transmitter and a receiver for NG-PON2. With this layout it is possible to build an OLT and, by redesigning some filters, also an ONU. This technology allows reducing the losses in the transmitter and in the receiver, increasing power budget, and also reducing the OEO conversions, which has been a major problem that operators want to surpass.

  13. NG2 Proteoglycan Ablation Reduces Foam Cell Formation and Atherogenesis via Decreased Low-Density Lipoprotein Retention by Synthetic Smooth Muscle Cells.

    PubMed

    She, Zhi-Gang; Chang, Yunchao; Pang, Hong-Bo; Han, Wenlong; Chen, Hou-Zao; Smith, Jeffrey W; Stallcup, William B

    2016-01-01

    Obesity and hyperlipidemia are critical risk factors for atherosclerosis. Because ablation of NG2 proteoglycan in mice leads to hyperlipidemia and obesity, we investigated the impact of NG2 ablation on atherosclerosis in apoE null mice. Immunostaining indicates that NG2 expression in plaque, primarily by synthetic smooth muscle cells, increases during atherogenesis. NG2 ablation unexpectedly results in decreased (30%) plaque development, despite aggravated obesity and hyperlipidemia. Mechanistic studies reveal that NG2-positive plaque synthetic smooth muscle cells in culture can sequester low-density lipoprotein to enhance foam-cell formation, processes in which NG2 itself plays direct roles. In agreement with these observations, low-density lipoprotein retention and lipid accumulation in the NG2/ApoE knockout aorta is 30% less than that seen in the control aorta. These results indicate that synthetic smooth muscle cell-dependent low-density lipoprotein retention and foam cell formation outweigh obesity and hyperlipidemia in promoting mouse atherogenesis. Our study sheds new light on the role of synthetic smooth muscle cells during atherogenesis. Blocking plaque NG2 or altering synthetic smooth muscle cells function may be promising therapeutic strategies for atherosclerosis. © 2015 American Heart Association, Inc.

  14. 24 CFR 964.150 - Funding tenant participation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Funding tenant participation. 964.150 Section 964.150 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND...

  15. 24 CFR 964.150 - Funding tenant participation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Funding tenant participation. 964.150 Section 964.150 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND...

  16. 24 CFR 964.150 - Funding tenant participation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Funding tenant participation. 964.150 Section 964.150 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND...

  17. 24 CFR 964.150 - Funding tenant participation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... serviceability, efficiency, economy and stability in the operation of the local development. The agreement must... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Funding tenant participation. 964.150 Section 964.150 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN...

  18. 47 CFR 73.150 - Directional antenna systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Directional antenna systems. 73.150 Section 73... BROADCAST SERVICES AM Broadcast Stations § 73.150 Directional antenna systems. (a) For each station employing a directional antenna, all determinations of service provided and interference caused shall be...

  19. 47 CFR 73.150 - Directional antenna systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Directional antenna systems. 73.150 Section 73... BROADCAST SERVICES AM Broadcast Stations § 73.150 Directional antenna systems. (a) For each station employing a directional antenna, all determinations of service provided and interference caused shall be...

  20. 47 CFR 73.150 - Directional antenna systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Directional antenna systems. 73.150 Section 73... BROADCAST SERVICES AM Broadcast Stations § 73.150 Directional antenna systems. (a) For each station employing a directional antenna, all determinations of service provided and interference caused shall be...

  1. 47 CFR 73.150 - Directional antenna systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Directional antenna systems. 73.150 Section 73... BROADCAST SERVICES AM Broadcast Stations § 73.150 Directional antenna systems. (a) For each station employing a directional antenna, all determinations of service provided and interference caused shall be...

  2. 47 CFR 73.150 - Directional antenna systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Directional antenna systems. 73.150 Section 73... BROADCAST SERVICES AM Broadcast Stations § 73.150 Directional antenna systems. (a) For each station employing a directional antenna, all determinations of service provided and interference caused shall be...

  3. Nogo Receptor Homolog NgR2 Expressed in Sensory DRG Neurons Controls Epidermal Innervation by Interaction with Versican

    PubMed Central

    Bäumer, Bastian E.; Kurz, Antje; Borrie, Sarah C.; Sickinger, Stephan; Dours-Zimmermann, María T.; Zimmermann, Dieter R.

    2014-01-01

    Primary sensory afferents of the dorsal root ganglion (DRG) that innervate the skin detect a wide range of stimuli, such as touch, temperature, pain, and itch. Different functional classes of nociceptors project their axons to distinct target zones within the developing skin, but the molecular mechanisms that regulate target innervation are less clear. Here we report that the Nogo66 receptor homolog NgR2 is essential for proper cutaneous innervation. NgR2−/− mice display increased density of nonpeptidergic nociceptors in the footpad and exhibit enhanced sensitivity to mechanical force and innocuous cold temperatures. These sensory deficits are not associated with any abnormality in morphology or density of DRG neurons. However, deletion of NgR2 renders nociceptive nonpeptidergic sensory neurons insensitive to the outgrowth repulsive activity of skin-derived Versican. Biochemical evidence shows that NgR2 specifically interacts with the G3 domain of Versican. The data suggest that Versican/NgR2 signaling at the dermo-epidermal junction acts in vivo as a local suppressor of axonal plasticity to control proper density of epidermal sensory fiber innervation. Our findings not only reveal the existence of a novel and unsuspected mechanism regulating epidermal target innervation, but also provide the first evidence for a physiological role of NgR2 in the peripheral nervous system. PMID:24478347

  4. Nogo receptor homolog NgR2 expressed in sensory DRG neurons controls epidermal innervation by interaction with Versican.

    PubMed

    Bäumer, Bastian E; Kurz, Antje; Borrie, Sarah C; Sickinger, Stephan; Dours-Zimmermann, María T; Zimmermann, Dieter R; Bandtlow, Christine E

    2014-01-29

    Primary sensory afferents of the dorsal root ganglion (DRG) that innervate the skin detect a wide range of stimuli, such as touch, temperature, pain, and itch. Different functional classes of nociceptors project their axons to distinct target zones within the developing skin, but the molecular mechanisms that regulate target innervation are less clear. Here we report that the Nogo66 receptor homolog NgR2 is essential for proper cutaneous innervation. NgR2(-/-) mice display increased density of nonpeptidergic nociceptors in the footpad and exhibit enhanced sensitivity to mechanical force and innocuous cold temperatures. These sensory deficits are not associated with any abnormality in morphology or density of DRG neurons. However, deletion of NgR2 renders nociceptive nonpeptidergic sensory neurons insensitive to the outgrowth repulsive activity of skin-derived Versican. Biochemical evidence shows that NgR2 specifically interacts with the G3 domain of Versican. The data suggest that Versican/NgR2 signaling at the dermo-epidermal junction acts in vivo as a local suppressor of axonal plasticity to control proper density of epidermal sensory fiber innervation. Our findings not only reveal the existence of a novel and unsuspected mechanism regulating epidermal target innervation, but also provide the first evidence for a physiological role of NgR2 in the peripheral nervous system.

  5. 9 CFR 590.150 - Official plant numbers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Official plant numbers. 590.150... of Service § 590.150 Official plant numbers. An official plant number shall be assigned to each plant granted inspection service. Such plant number shall be used to identify all containers of inspected...

  6. 9 CFR 590.150 - Official plant numbers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Official plant numbers. 590.150... of Service § 590.150 Official plant numbers. An official plant number shall be assigned to each plant granted inspection service. Such plant number shall be used to identify all containers of inspected...

  7. 9 CFR 590.150 - Official plant numbers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Official plant numbers. 590.150... of Service § 590.150 Official plant numbers. An official plant number shall be assigned to each plant granted inspection service. Such plant number shall be used to identify all containers of inspected...

  8. 9 CFR 590.150 - Official plant numbers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Official plant numbers. 590.150... of Service § 590.150 Official plant numbers. An official plant number shall be assigned to each plant granted inspection service. Such plant number shall be used to identify all containers of inspected...

  9. 7 CFR 1924.150 - OMB Control Number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false OMB Control Number. 1924.150 Section 1924.150... Number. The reporting requirements contained in this subpart have been approved by the Office of Management and Budget (OMB) and have been assigned OMB control number 0575-0164. Public reporting burden for...

  10. 7 CFR 1924.150 - OMB Control Number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true OMB Control Number. 1924.150 Section 1924.150... Number. The reporting requirements contained in this subpart have been approved by the Office of Management and Budget (OMB) and have been assigned OMB control number 0575-0164. Public reporting burden for...

  11. 7 CFR 1924.150 - OMB Control Number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false OMB Control Number. 1924.150 Section 1924.150... Number. The reporting requirements contained in this subpart have been approved by the Office of Management and Budget (OMB) and have been assigned OMB control number 0575-0164. Public reporting burden for...

  12. 45 CFR 150.457 - Review by Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Review by Administrator. 150.457 Section 150.457 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS... Administrator. (a) The Administrator of CMS (which for purposes of this subsection may include his or her...

  13. 7 CFR 457.150 - Dry bean crop insurance provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Dry bean crop insurance provisions. 457.150 Section 457.150 Agriculture Regulations of the Department of Agriculture (Continued) FEDERAL CROP INSURANCE CORPORATION, DEPARTMENT OF AGRICULTURE COMMON CROP INSURANCE REGULATIONS § 457.150 Dry bean crop insurance...

  14. High-Throughput Testing of Urogenital and Extragenital Specimens for Detection of Chlamydia Trachomatis and Neisseria Gonorrhoeae with Cobas® CT/NG

    PubMed Central

    Marlowe, Elizabeth M.; Hardy, David; Krevolin, Mark; Gohl, Peter; Bertram, Alexander; Arcenas, Rodney; Seiverth, Britta; Schneider, Tanja; Liesenfeld, Oliver

    2017-01-01

    We compared the analytical and clinical performance of cobas® CT/NG for use on the Cobas® 6800/8800 Systems with the Cobas® 4800 CT/NG Test from urogenital and extragenital specimens in over 12,000 specimens from both male and female subjects in Germany and the United States. The analytical sensitivity was ≤40 EB/ml for Chlamydia trachomatis (CT) and ≤1 CFU/ml for Neisseria gonorrhoeae (NG). Using clinical specimens, the overall percent agreement with the Cobas® 4800 CT/NG Test was >98.5%. Across urogenital specimens, there were 93 discrepant specimens; 76 (93.8%) of 81 CT discrepant specimens were 6800+/4800– and 10 (83.3%) of 12 NG discrepant specimens were 6800+/4800–. Sequencing verified CT results for 45 (61.6%) of 73 samples positive by 6800 and 1 (20%) of 5 positive by 4800. Similarly, 7 (70.0%) of 10 NG samples positive by 6800 and 1 of 2 positive by 4800 were confirmed by sequencing. Among discrepant extragenital specimens (all 6800+/4800–), 7 (50%) of 14 oropharyngeal and 23 (76.7%) of 30 anorectal CT discordant samples were confirmed as CT positive by sequencing; all 8 anorectal and 20 (90.9%) of 22 oropharyngeal NG discordant results were also confirmed as NG positive. In conclusion, Cobas® CT/NG for use on the Cobas® 6800/8800 Systems provides high-throughput automated solutions for sexually transmitted infection (STI) screening programs. PMID:29034107

  15. High-Throughput Testing of Urogenital and Extragenital Specimens for Detection of Chlamydia Trachomatis and Neisseria Gonorrhoeae with Cobas® CT/NG.

    PubMed

    Marlowe, Elizabeth M; Hardy, David; Krevolin, Mark; Gohl, Peter; Bertram, Alexander; Arcenas, Rodney; Seiverth, Britta; Schneider, Tanja; Liesenfeld, Oliver

    2017-09-01

    We compared the analytical and clinical performance of cobas ® CT/NG for use on the Cobas ® 6800/8800 Systems with the Cobas ® 4800 CT/NG Test from urogenital and extragenital specimens in over 12,000 specimens from both male and female subjects in Germany and the United States. The analytical sensitivity was ≤40 EB/ml for Chlamydia trachomatis (CT) and ≤1 CFU/ml for Neisseria gonorrhoeae (NG). Using clinical specimens, the overall percent agreement with the Cobas ® 4800 CT/NG Test was >98.5%. Across urogenital specimens, there were 93 discrepant specimens; 76 (93.8%) of 81 CT discrepant specimens were 6800+/4800- and 10 (83.3%) of 12 NG discrepant specimens were 6800+/4800-. Sequencing verified CT results for 45 (61.6%) of 73 samples positive by 6800 and 1 (20%) of 5 positive by 4800. Similarly, 7 (70.0%) of 10 NG samples positive by 6800 and 1 of 2 positive by 4800 were confirmed by sequencing. Among discrepant extragenital specimens (all 6800+/4800-), 7 (50%) of 14 oropharyngeal and 23 (76.7%) of 30 anorectal CT discordant samples were confirmed as CT positive by sequencing; all 8 anorectal and 20 (90.9%) of 22 oropharyngeal NG discordant results were also confirmed as NG positive. In conclusion, Cobas ® CT/NG for use on the Cobas ® 6800/8800 Systems provides high-throughput automated solutions for sexually transmitted infection (STI) screening programs.

  16. 20 CFR 402.150 - Release of records.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Release of records. 402.150 Section 402.150 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC... reading rooms. (b) Poor copy. If we cannot make a legible copy of a record to be released, we do not...

  17. 20 CFR 402.150 - Release of records.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Release of records. 402.150 Section 402.150 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC... reading rooms. (b) Poor copy. If we cannot make a legible copy of a record to be released, we do not...

  18. 20 CFR 402.150 - Release of records.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Release of records. 402.150 Section 402.150 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC... reading rooms. (b) Poor copy. If we cannot make a legible copy of a record to be released, we do not...

  19. 20 CFR 402.150 - Release of records.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Release of records. 402.150 Section 402.150 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC... reading rooms. (b) Poor copy. If we cannot make a legible copy of a record to be released, we do not...

  20. 20 CFR 402.150 - Release of records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Release of records. 402.150 Section 402.150 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC... reading rooms. (b) Poor copy. If we cannot make a legible copy of a record to be released, we do not...

  1. 33 CFR 138.150 - Service of process.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Service of process. 138.150... Pollution (Vessels) § 138.150 Service of process. (a) When executing the forms required by this subpart... as its agent for service of process for purposes of this subpart and for receipt of notices of...

  2. 10 CFR 150.15 - Persons not exempt.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Persons not exempt. 150.15 Section 150.15 Energy NUCLEAR.... (2) The export from or import into the United States of byproduct, source, or special nuclear..., source, or special nuclear waste materials, as defined in regulations or orders of the Commission. For...

  3. 33 CFR 150.300 - What does this subpart do?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false What does this subpart do? 150.300 Section 150.300 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Vessel Navigation § 150.300 What does this subpart do...

  4. 33 CFR 150.300 - What does this subpart do?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false What does this subpart do? 150.300 Section 150.300 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Vessel Navigation § 150.300 What does this subpart do...

  5. 45 CFR 150.431 - Acknowledgment of request for hearing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Acknowledgment of request for hearing. 150.431 Section 150.431 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.431...

  6. 45 CFR 150.411 - Dismissal of request for hearing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Dismissal of request for hearing. 150.411 Section 150.411 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.411...

  7. 45 CFR 150.411 - Dismissal of request for hearing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Dismissal of request for hearing. 150.411 Section 150.411 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.411...

  8. 45 CFR 150.427 - Form and service of submissions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Form and service of submissions. 150.427 Section 150.427 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.427 Form...

  9. 45 CFR 150.427 - Form and service of submissions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Form and service of submissions. 150.427 Section 150.427 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.427 Form...

  10. 45 CFR 150.431 - Acknowledgment of request for hearing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Acknowledgment of request for hearing. 150.431 Section 150.431 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.431...

  11. Wave Energy Prize - 1/50th Testing - Team Flapper/Harvest

    DOE Data Explorer

    Wesley Scharmen

    2015-12-18

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the Team Flapper/Harvest, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  12. Mechanism of 150-cavity formation in influenza neuraminidase

    PubMed Central

    Amaro, Rommie E.; Swift, Robert V.; Votapka, Lane; Li, Wilfred W.; Walker, Ross C.; Bush, Robin M.

    2011-01-01

    The recently discovered 150-cavity in the active site of group-1 influenza A neuraminidase (NA) proteins provides a target for rational structure-based drug development to counter the increasing frequency of antiviral resistance in influenza. Surprisingly, the 2009 H1N1 pandemic virus (09N1) neuramidase was crystalized without the 150-cavity characteristic of group-1 NAs. Here we demonstrate, through a total sum of 1.6 μs of biophysical simulations, that 09N1 NA exists in solution preferentially with an open 150-cavity. Comparison with simulations using avian N1, human N2 and 09N1 with a I149V mutation and an extensive bioinformatics analysis suggests that the conservation of a key salt bridge is crucial in the stabilization of the 150-cavity across both subtypes. This result provides an atomic-level structural understanding of the recent finding that antiviral compounds designed to take advantage of contacts in the 150-cavity can inactivate both 2009 H1N1 pandemic and avian H5N1 viruses. PMID:21750542

  13. Wave Energy Prize - 1/50th Testing - M3 Wave

    DOE Data Explorer

    Wesley Scharmen

    2016-01-08

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the M3 Wave team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  14. Wave Energy Prize - 1/50th Testing - RTI Wave Power

    DOE Data Explorer

    Wesley Scharmen

    2015-12-18

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the RTI Wave Power team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  15. Wave Energy Prize - 1/50th Testing - Atlas Ocean Systems

    DOE Data Explorer

    Wesley Scharmen

    2015-12-04

    This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the Atlas Ocean Systems team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

  16. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

  17. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

  18. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

  19. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

  20. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

  1. 33 CFR 150.555 - How must cranes be maintained?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false How must cranes be maintained? 150.555 Section 150.555 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Operations § 150.555 How must cranes be maintained? Cranes must be operated, maintained, and tested in...

  2. 21 CFR 1271.150 - Current good tissue practice requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....150 Section 1271.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.150... implemented for reproductive HCT/Ps described in § 1271.10 and regulated solely under section 361 of the...

  3. 21 CFR 1271.150 - Current good tissue practice requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ....150 Section 1271.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.150... implemented for reproductive HCT/Ps described in § 1271.10 and regulated solely under section 361 of the...

  4. 21 CFR 1271.150 - Current good tissue practice requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ....150 Section 1271.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.150... implemented for reproductive HCT/Ps described in § 1271.10 and regulated solely under section 361 of the...

  5. 21 CFR 1271.150 - Current good tissue practice requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ....150 Section 1271.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.150... implemented for reproductive HCT/Ps described in § 1271.10 and regulated solely under section 361 of the...

  6. 33 CFR 150.555 - How must cranes be maintained?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false How must cranes be maintained? 150.555 Section 150.555 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Operations § 150.555 How must cranes be maintained? Cranes must be operated, maintained, and tested in...

  7. 13 CFR 120.150 - What are SBA's lending criteria?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are SBA's lending criteria? 120.150 Section 120.150 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Credit Criteria for Sba Loans § 120.150 What are SBA's lending...

  8. 45 CFR 150.405 - Filing of request for hearing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Filing of request for hearing. 150.405 Section 150.405 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.405 Filing of...

  9. 45 CFR 150.405 - Filing of request for hearing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Filing of request for hearing. 150.405 Section 150.405 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.405 Filing of...

  10. 41 CFR 105-8.150-2 - Methods.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Methods. 105-8.150-2... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.150-2 Methods. (a... construction of new facilities, use of accessible rolling stock, or any other methods that result in making its...

  11. 41 CFR 105-8.150-2 - Methods.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Methods. 105-8.150-2... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.150-2 Methods. (a... construction of new facilities, use of accessible rolling stock, or any other methods that result in making its...

  12. 41 CFR 105-8.150-2 - Methods.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Methods. 105-8.150-2... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.150-2 Methods. (a... construction of new facilities, use of accessible rolling stock, or any other methods that result in making its...

  13. 41 CFR 105-8.150-2 - Methods.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Methods. 105-8.150-2... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.150-2 Methods. (a... construction of new facilities, use of accessible rolling stock, or any other methods that result in making its...

  14. 41 CFR 105-8.150-2 - Methods.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Methods. 105-8.150-2... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.150-2 Methods. (a... construction of new facilities, use of accessible rolling stock, or any other methods that result in making its...

  15. 32 CFR 150.6 - Signing of papers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Signing of papers. 150.6 Section 150.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY... belief of the persons signing the paper and that the paper is filed in good faith and not for purposes of...

  16. 32 CFR 150.6 - Signing of papers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Signing of papers. 150.6 Section 150.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY... belief of the persons signing the paper and that the paper is filed in good faith and not for purposes of...

  17. 32 CFR 150.6 - Signing of papers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Signing of papers. 150.6 Section 150.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY... belief of the persons signing the paper and that the paper is filed in good faith and not for purposes of...

  18. 32 CFR 150.6 - Signing of papers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Signing of papers. 150.6 Section 150.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY... belief of the persons signing the paper and that the paper is filed in good faith and not for purposes of...

  19. 32 CFR 150.6 - Signing of papers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Signing of papers. 150.6 Section 150.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO MILITARY... belief of the persons signing the paper and that the paper is filed in good faith and not for purposes of...

  20. 33 CFR 110.150 - Block Island Sound, N.Y.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Block Island Sound, N.Y. 110.150 Section 110.150 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.150 Block Island Sound, N.Y. (a) The anchorage ground. A 3/4...

  1. 33 CFR 110.150 - Block Island Sound, N.Y.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Block Island Sound, N.Y. 110.150 Section 110.150 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.150 Block Island Sound, N.Y. (a) The anchorage ground. A 3/4...

  2. 33 CFR 110.150 - Block Island Sound, N.Y.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Block Island Sound, N.Y. 110.150 Section 110.150 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.150 Block Island Sound, N.Y. (a) The anchorage ground. A 3/4...

  3. Comparison of GMT presto assay and Roche cobas® 4800 CT/NG assay for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in dry swabs.

    PubMed

    de Waaij, Dewi J; Dubbink, Jan Henk; Peters, Remco P H; Ouburg, Sander; Morré, Servaas A

    2015-11-01

    Urogenital Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are the most prevalent bacterial STIs worldwide. Molecular tests are the standard for the detection of CT and NG, as these are difficult to culture. The recently introduced CE-IVD marked GMT Presto assay promises to be a valuable addition in CT and NG diagnostics. The advantage of the Presto assay is that it works on many PCR systems and the DNA can be isolated by any system.We compared the Presto assay to the widely used Roche cobas® 4800 CT/NG test for the detection of CT and NG in 612 vaginal and rectal dry collected swabs. Discrepant samples were tested by the TIB MOLBIOL Lightmix Kit 480 HT CT/NG assay. The alloyed gold standard was defined as two concurring Presto and cobas® 4800 results, or, with discrepant Presto and cobas® results, two concurring results of either test together with the Lightmix Kit 480 HT CT/NG assay. For the Presto assay,we observed 77 CT positive (13%) and 22 NG positive (3,6%) vaginal samples, and 41 CT positive (6,7%) and 11 NG positive (1,8%) rectal samples. For the cobas® 4800 assay,we observed 77 CT positive (13%) and 21NG positive (3,4%) vaginal samples, and 39 CT positive (6,4%) and 11 NG positive (1,8%) rectal samples. Ten CT samples were discrepant between Presto and cobas® 4800 CT/NG assays, while two NG samples were discrepant. CT sensitivity in both assays was 100% compared to the alloyed gold standard. The sensitivity was 100% for both vaginal and rectal dry swabs, underlining the suitability of these sample types for detection of CT and NG. The Presto assay is therefore valuable for molecular detection of CT and NG in dry vaginal and rectal swabs.

  4. 9 CFR 590.150 - Official plant numbers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... products prepared in the plant which are capable of use as human food. A plant shall not have more than one... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Official plant numbers. 590.150... of Service § 590.150 Official plant numbers. An official plant number shall be assigned to each plant...

  5. 32 CFR 150.7 - Computation of time.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Computation of time. 150.7 Section 150.7 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO..., Sunday, or legal holiday, or, when the act to be done is the filing of a paper in court, a day on which...

  6. 32 CFR 150.7 - Computation of time.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Computation of time. 150.7 Section 150.7 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO..., Sunday, or legal holiday, or, when the act to be done is the filing of a paper in court, a day on which...

  7. 32 CFR 150.7 - Computation of time.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Computation of time. 150.7 Section 150.7 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO..., Sunday, or legal holiday, or, when the act to be done is the filing of a paper in court, a day on which...

  8. 32 CFR 150.7 - Computation of time.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Computation of time. 150.7 Section 150.7 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO..., Sunday, or legal holiday, or, when the act to be done is the filing of a paper in court, a day on which...

  9. 32 CFR 150.7 - Computation of time.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Computation of time. 150.7 Section 150.7 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE REGULATIONS PERTAINING TO..., Sunday, or legal holiday, or, when the act to be done is the filing of a paper in court, a day on which...

  10. 44 CFR 150.6 - Design and procurement of awards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Design and procurement of awards. 150.6 Section 150.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY FIRE PREVENTION AND CONTROL PUBLIC SAFETY AWARDS TO PUBLIC SAFETY OFFICERS § 150.6 Design and procurement of awards. (a...

  11. 44 CFR 150.6 - Design and procurement of awards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Design and procurement of awards. 150.6 Section 150.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY FIRE PREVENTION AND CONTROL PUBLIC SAFETY AWARDS TO PUBLIC SAFETY OFFICERS § 150.6 Design and procurement of awards. (a...

  12. 44 CFR 150.6 - Design and procurement of awards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Design and procurement of awards. 150.6 Section 150.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY FIRE PREVENTION AND CONTROL PUBLIC SAFETY AWARDS TO PUBLIC SAFETY OFFICERS § 150.6 Design and procurement of awards. (a...

  13. 46 CFR Appendix IV to Part 150 - Data Sheet

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Data Sheet IV Appendix IV to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, App. IV Appendix IV to Part 150—Data Sheet EC02FE91.080 EC02FE91.081 ...

  14. 46 CFR Appendix IV to Part 150 - Data Sheet

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Data Sheet IV Appendix IV to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, App. IV Appendix IV to Part 150—Data Sheet EC02FE91.080 EC02FE91.081 ...

  15. 46 CFR Appendix IV to Part 150 - Data Sheet

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Data Sheet IV Appendix IV to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, App. IV Appendix IV to Part 150—Data Sheet EC02FE91.080 EC02FE91.081 ...

  16. 46 CFR Appendix IV to Part 150 - Data Sheet

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Data Sheet IV Appendix IV to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, App. IV Appendix IV to Part 150—Data Sheet EC02FE91.080 EC02FE91.081 ...

  17. 46 CFR Appendix IV to Part 150 - Data Sheet

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Data Sheet IV Appendix IV to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, App. IV Appendix IV to Part 150—Data Sheet EC02FE91.080 EC02FE91.081 ...

  18. 42 CFR 456.150 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals § 456.150 Scope. This subpart prescribes requirements for control of utilization of inpatient services in mental hospitals, including...

  19. Reducing adverse self-medication behaviors in older adults with the Next Generation Personal Education Program (PEP-NG): Design and methodology

    PubMed Central

    Neafsey, Patricia J; Anderson, Elizabeth; Coleman, Craig; Lin, Carolyn A; M’lan, Cyr E; Walsh, Stephen

    2009-01-01

    A randomized controlled efficacy trial targeting older adults with hypertension is providing a tailored education intervention with a Next Generation Personal Education Program (PEP-NG) in primary care practices in New England. Ten participating advanced practice registered nurses (APRNs) completed online knowledge and self-efficacy measures pre-onsite training and twice more after completing a continuing education program. Patient participants self-refer in response to study recruitment brochures and posters. Twenty-four participants from each APRN practice (total N = 240) are randomly assigned by the PEP-NG software to either control (data collection and four routine APRN visits) or tailored intervention (PEP-NG interface and four focused APRN visits) conditions. Patients access the PEP-NG interface via wireless tablet and use a stylus to answer demographic, knowledge, and self-efficacy questions as well as prescription and over-the-counter self-medication practice questions. The PEP-NG analyzes patient-reported information and delivers tailored educational content. Patients’ outcome measures are self-reported antihypertensive medication adherence, blood pressure, knowledge and self-efficacy concerning potential adverse self-medication practices, adverse self-medication behavior “risk” score and satisfaction with the PEP-NG and APRN provider relationship. APRN outcome measures are knowledge and self-efficacy concerning adverse self-medication practices, self-efficacy for communicating with older adults and satisfaction with the PEP-NG. Time–motion and cost–benefit analyses will be conducted. PMID:20016796

  20. 40 CFR 161.150 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements § 161.150 General. (a) Applicability. This subpart describes the product chemistry data that are required to support the registration...

  1. 40 CFR 161.150 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements § 161.150 General. (a) Applicability. This subpart describes the product chemistry data that are required to support the registration...

  2. One step hydrothermal synthesis of 3D CoS2@MoS2-NG for high performance supercapacitors

    NASA Astrophysics Data System (ADS)

    Meng, Qi; Chen, Yizhi; Zhu, Wenkun; Zhang, Ling; Yang, Xiaoyong; Duan, Tao

    2018-07-01

    A three-dimensional (3D) MoS2 coated CoS2-nitrogen doped graphene (NG) (CoS2@MoS2-NG) hybrid has been synthesized by a one step hydrothermal method as supercapacitor (SC) electrode material for the first time. Such a composite consists of NG embedded with stacked CoS2@MoS2 sheets. With a 3D skeleton, it prevents the agglomeration of CoS2@MoS2 nanoparticles, resulting in sound conductivity, rich porous structures and a large surface area. The results indicate that CoS2@MoS2-NG has higher specific capacitance (198 F g‑1 at 1 A g‑1), better rate performance (with about 56.57% from 1 to 16 A g‑1) and an improved cycle stability (with about 96.97% after 1000 cycles). It is an ideal candidate for SC electrode materials.

  3. One step hydrothermal synthesis of 3D CoS2@MoS2-NG for high performance supercapacitors.

    PubMed

    Meng, Qi; Chen, Yizhi; Zhu, Wenkun; Zhang, Ling; Yang, Xiaoyong; Duan, Tao

    2018-07-20

    A three-dimensional (3D) MoS 2 coated CoS 2 -nitrogen doped graphene (NG) (CoS 2 @MoS 2 -NG) hybrid has been synthesized by a one step hydrothermal method as supercapacitor (SC) electrode material for the first time. Such a composite consists of NG embedded with stacked CoS 2 @MoS 2 sheets. With a 3D skeleton, it prevents the agglomeration of CoS 2 @MoS 2 nanoparticles, resulting in sound conductivity, rich porous structures and a large surface area. The results indicate that CoS 2 @MoS 2 -NG has higher specific capacitance (198 F g -1 at 1 A g -1 ), better rate performance (with about 56.57% from 1 to 16 A g -1 ) and an improved cycle stability (with about 96.97% after 1000 cycles). It is an ideal candidate for SC electrode materials.

  4. 26 CFR 1.50A-6 - Estates and trusts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Estates and trusts. 1.50A-6 Section 1.50A-6... Computing Credit for Expenses of Work Incentive Programs § 1.50A-6 Estates and trusts. (a) In general—(1) Termination of employment by an estate or trust. If an estate or trust terminates (in a termination subject to...

  5. Human Protein Arginine Methyltransferase 7 (PRMT7) Is a Type III Enzyme Forming ω-NG-Monomethylated Arginine Residues*

    PubMed Central

    Zurita-Lopez, Cecilia I.; Sandberg, Troy; Kelly, Ryan; Clarke, Steven G.

    2012-01-01

    Full-length human protein arginine methyltransferase 7 (PRMT7) expressed as a fusion protein in Escherichia coli was initially found to generate only ω-NG-monomethylated arginine residues in small peptides, suggesting that it is a type III enzyme. A later study, however, characterized fusion proteins of PRMT7 expressed in bacterial and mammalian cells as a type II/type I enzyme, capable of producing symmetrically dimethylated arginine (type II activity) as well as small amounts of asymmetric dimethylarginine (type I activity). We have sought to clarify the enzymatic activity of human PRMT7. We analyzed the in vitro methylation products of a glutathione S-transferase (GST)-PRMT7 fusion protein with robust activity using a variety of arginine-containing synthetic peptides and protein substrates, including a GST fusion with the N-terminal domain of fibrillarin (GST-GAR), myelin basic protein, and recombinant human histones H2A, H2B, H3, and H4. Regardless of the methylation reaction conditions (incubation time, reaction volume, and substrate concentration), we found that PRMT7 only produces ω-NG-monomethylarginine with these substrates. In control experiments, we showed that mammalian GST-PRMT1 and Myc-PRMT5 were, unlike PRMT7, able to dimethylate both peptide P-SmD3 and SmB/D3 to give the expected asymmetric and symmetric products, respectively. These experiments show that PRMT7 is indeed a type III human methyltransferase capable of forming only ω-NG-monomethylarginine, not asymmetric ω-NG,NG-dimethylarginine or symmetric ω-NG,NG′-dimethylarginine, under the conditions tested. PMID:22241471

  6. 14 CFR 150.7 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AIRPORT NOISE COMPATIBILITY PLANNING General Provisions § 150.7 Definitions. As used in this part, unless... for the geographic area in which the airport in question is located. Restriction affecting flight...

  7. 14 CFR 150.7 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AIRPORT NOISE COMPATIBILITY PLANNING General Provisions § 150.7 Definitions. As used in this part, unless... for the geographic area in which the airport in question is located. Restriction affecting flight...

  8. 14 CFR 150.7 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AIRPORT NOISE COMPATIBILITY PLANNING General Provisions § 150.7 Definitions. As used in this part, unless... for the geographic area in which the airport in question is located. Restriction affecting flight...

  9. 14 CFR 150.7 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AIRPORT NOISE COMPATIBILITY PLANNING General Provisions § 150.7 Definitions. As used in this part, unless... for the geographic area in which the airport in question is located. Restriction affecting flight...

  10. 14 CFR 150.7 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AIRPORT NOISE COMPATIBILITY PLANNING General Provisions § 150.7 Definitions. As used in this part, unless... for the geographic area in which the airport in question is located. Restriction affecting flight...

  11. 40 CFR 264.150 - State assumption of responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false State assumption of responsibility. 264.150 Section 264.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL...

  12. 50 CFR 300.150 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... Nationals Fishing in Russian Fisheries § 300.150 Purpose. This subpart regulates U.S. nationals fishing in the Russian fisheries and implements the Agreement between the Government of the United States of...

  13. 50 CFR 300.150 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... Nationals Fishing in Russian Fisheries § 300.150 Purpose. This subpart regulates U.S. nationals fishing in the Russian fisheries and implements the Agreement between the Government of the United States of...

  14. 50 CFR 300.150 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... Nationals Fishing in Russian Fisheries § 300.150 Purpose. This subpart regulates U.S. nationals fishing in the Russian fisheries and implements the Agreement between the Government of the United States of...

  15. 50 CFR 300.150 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... Nationals Fishing in Russian Fisheries § 300.150 Purpose. This subpart regulates U.S. nationals fishing in the Russian fisheries and implements the Agreement between the Government of the United States of...

  16. 50 CFR 300.150 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... Nationals Fishing in Russian Fisheries § 300.150 Purpose. This subpart regulates U.S. nationals fishing in the Russian fisheries and implements the Agreement between the Government of the United States of...

  17. Voltage-gated sodium channel expression and action potential generation in differentiated NG108-15 cells.

    PubMed

    Liu, Jinxu; Tu, Huiyin; Zhang, Dongze; Zheng, Hong; Li, Yu-Long

    2012-10-25

    The generation of action potential is required for stimulus-evoked neurotransmitter release in most neurons. Although various voltage-gated ion channels are involved in action potential production, the initiation of the action potential is mainly mediated by voltage-gated Na+ channels. In the present study, differentiation-induced changes of mRNA and protein expression of Na+ channels, Na+ currents, and cell membrane excitability were investigated in NG108-15 cells. Whole-cell patch-clamp results showed that differentiation (9 days) didn't change cell membrane excitability, compared to undifferentiated state. But differentiation (21 days) induced the action potential generation in 45.5% of NG108-15 cells (25/55 cells). In 9-day-differentiated cells, Na+ currents were mildly increased, which was also found in 21-day differentiated cells without action potential. In 21-day differentiated cells with action potential, Na+ currents were significantly enhanced. Western blot data showed that the expression of Na+ channels was increased with differentiated-time dependent manner. Single-cell real-time PCR data demonstrated that the expression of Na+ channel mRNA was increased by 21 days of differentiation in NG108-15 cells. More importantly, the mRNA level of Na+ channels in cells with action potential was higher than that in cells without action potential. Differentiation induces expression of voltage-gated Na+ channels and action potential generation in NG108-15 cells. A high level of the Na+ channel density is required for differentiation-triggered action potential generation.

  18. Imaging Cold Gas to 1 kpc scales in high-redshift galaxies with the ngVLA

    NASA Astrophysics Data System (ADS)

    Casey, Caitlin; Narayanan, Desika; Dave, Romeel; Hung, Chao-Ling; Champagne, Jaclyn; Carilli, Chris Luke; Decarli, Roberto; Murphy, Eric J.; Popping, Gergo; Riechers, Dominik; Somerville, Rachel S.; Walter, Fabian

    2017-01-01

    The next generation Very Large Array (ngVLA) will revolutionize our understanding of the distant Universe via the detection of cold molecular gas in the first galaxies. Its impact on studies of galaxy characterization via detailed gas dynamics will provide crucial insight on dominant physical drivers for star-formation in high redshift galaxies, including the exchange of gas from scales of the circumgalactic medium down to resolved clouds on mass scales of ~10^5 M_sun. In this study, we employ a series of high-resolution, cosmological, hydrodynamic zoom simulations from the MUFASA simulation suite and a CASA simulator to generate mock ngVLA observations. Based on a direct comparison between the inferred results from our mock observations and the cosmological simulations, we investigate the capabilities of ngVLA to constrain the mode of star formation, dynamical mass, and molecular gas kinematics in individual high-redshift galaxies using cold gas tracers like CO(1-0) and CO(2-1). Using the Despotic radiative transfer code that encompasses simultaneous thermal and statistical equilibrium in calculating the molecular and atomic level populations, we generate parallel mock observations of high-J transitions of CO and C+ from ALMA for comparison. The factor of 100 times improvement in mapping speed for the ngVLA beyond the Jansky VLA and the proposed ALMA Band 1 will make these detailed, high-resolution imaging and kinematic studies routine at z=2 and beyond.

  19. 46 CFR 180.150 - Survival craft embarkation arrangements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft embarkation arrangements. 180.150 Section... (UNDER 100 GROSS TONS) LIFESAVING EQUIPMENT AND ARRANGEMENTS Survival Craft Arrangements and Equipment § 180.150 Survival craft embarkation arrangements. (a) A launching appliance approved under approval...

  20. 13 CFR 107.150 - Management-ownership diversity requirement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... with any of your Associates. A single “acceptable” Institutional Investor may be substituted for two or... if exempt from Federal income taxation; and (vi) Other Institutional Investors satisfactory to SBA... requirement. 107.150 Section 107.150 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL...

  1. 13 CFR 107.150 - Management-ownership diversity requirement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... with any of your Associates. A single “acceptable” Institutional Investor may be substituted for two or... if exempt from Federal income taxation; and (vi) Other Institutional Investors satisfactory to SBA... requirement. 107.150 Section 107.150 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL...

  2. 13 CFR 107.150 - Management-ownership diversity requirement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... with any of your Associates. A single “acceptable” Institutional Investor may be substituted for two or... if exempt from Federal income taxation; and (vi) Other Institutional Investors satisfactory to SBA... requirement. 107.150 Section 107.150 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL...

  3. 44 CFR 150.4 - Nomination and selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Nomination and selection criteria. 150.4 Section 150.4 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY FIRE PREVENTION AND CONTROL PUBLIC SAFETY AWARDS TO PUBLIC SAFETY OFFICERS...

  4. 40 CFR 51.150 - Classification of regions for episode plans.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... plans. 51.150 Section 51.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Prevention of Air Pollution Emergency Episodes § 51.150 Classification of regions for episode plans. (a) This section...

  5. Predictive value of different prostate-specific antigen-based markers in men with baseline total prostate-specific antigen <2.0 ng/mL.

    PubMed

    Fujizuka, Yuji; Ito, Kazuto; Oki, Ryo; Suzuki, Rie; Sekine, Yoshitaka; Koike, Hidekazu; Matsui, Hiroshi; Shibata, Yasuhiro; Suzuki, Kazuhiro

    2017-08-01

    To investigate the predictive value of various molecular forms of prostate-specific antigen in men with baseline prostate-specific antigen <2.0 ng/mL. The case cohort comprised 150 men with a baseline prostate-specific antigen level <2.0 ng/mL, and who developed prostate cancer within 10 years. The control cohort was 300 baseline prostate-specific antigen- and age-adjusted men who did not develop prostate cancer. Serum prostate-specific antigen, free prostate-specific antigen, and [-2] proenzyme prostate-specific antigen were measured at baseline and last screening visit. The predictive impact of baseline prostate-specific antigen- and [-2] proenzyme prostate-specific antigen-related indices on developing prostate cancer was investigated. The predictive impact of those indices at last screening visit and velocities from baseline to final screening on tumor aggressiveness were also investigated. The baseline free to total prostate-specific antigen ratio was a significant predictor of prostate cancer development. The odds ratio was 6.08 in the lowest quintile baseline free to total prostate-specific antigen ratio subgroup. No serum indices at diagnosis were associated with tumor aggressiveness. The Prostate Health Index velocity and [-2] proenzyme prostate-specific antigen/free prostate-specific antigen velocity significantly increased in patients with higher risk D'Amico risk groups and higher Gleason scores. Free to total prostate-specific antigen ratio in men with low baseline prostate-specific antigen levels seems to predict the risk of developing prostate cancer, and it could be useful for a more effective individualized screening system. Longitudinal changes in [-2] proenzyme prostate-specific antigen-related indices seem to correlate with tumor aggressiveness, and they could be used as prognostic tool before treatment and during active surveillance. © 2017 The Japanese Urological Association.

  6. Beta-gamma spectroscopy of the neutron-rich 150Ba

    NASA Astrophysics Data System (ADS)

    Yokoyama, R.; Ideguchi, E.; Simpson, G. S.; Tanaka, Mn; Nishimura, S.; Doornenbal, P.; Lorusso, G.; Söderström, P.-A.; Sumikama, T.; Wu, J.; Xu, Z. Y.; Aoi, N.; Baba, H.; Bello Garrote, F. L.; Benzoni, G.; Browne, F.; Daido, R.; Fang, Y.; Fukuda, N.; Gottardo, A.; Gey, G.; Go, S.; Inabe, N.; Isobe, T.; Kameda, D.; Kobayashi, K.; Kobayashi, M.; Kojouharov, I.; Komatsubara, T.; Kubo, T.; Kurz, N.; Kuti, I.; Li, Z.; Matsushita, M.; Michimasa, S.; Moon, C. B.; Nishibata, H.; Nishizuka, I.; Odahara, A.; Patel, Z.; Rice, S.; Sahin, E.; Sakurai, H.; Schaffner, H.; Sinclair, L.; Suzuki, H.; Takeda, H.; Taprogge, J.; Vajta, Zs; Watanabe, H.; Yagi, A.; Inakura, T.

    2018-04-01

    Excited states in the neutron-rich nucleus ^{150}Ba have been observed via β-γ spectroscopy at the Radioactive Isotope Beam Factory, RIKEN Nishina Center. The ^{150}Ba ions were produced by the in-flight fission of a ^{238}U beam with an energy of 345 MeV/nucleon. The E(2+) energy of ^{150}Ba was identified at 100 keV, which is the lowest known in the neutron-rich Ba isotopes. A γ-ray peak was also observed at 597 keV. A mean-field calculation with a fully 3D real space was performed and a static octupole deformation was obtained for the Ba isotopes. K^{π}=0- and 1- excited states with significant octupole collectivity were newly predicted at around or lower than 1 MeV on the ground state of ^{150}Ba by a random-phase approximation calculation. The 597 keV γ ray can be interpreted as a negative-parity state, showing that ^{150}Ba may possess octupole collectivity.

  7. 150-nm generation lithography equipment

    NASA Astrophysics Data System (ADS)

    Deguchi, Nobuyoshi; Uzawa, Shigeyuki

    1999-07-01

    Lithography by step-and-scan exposure is expected to be the mainstream for semiconductor manufacturing below 180 nm resolution patterns. We have developed a scanner for 150 nm features on either 200 mm or 300 mm wafers. For this system, the synchronous stage system has been redesigned which makes it possible to improve imaging performance and overlay accuracy. A new 300 mm wafer stage enhances productivity while weighting almost the same as the stage for 200 mm wafers. The mainbody mechanical frame incorporates reactive force receiver system to counter the inertial energy and vibrational issues associated with high speed wafer and reticle stage scanning. This report outlines the total system design, new technologies and performance data of the Cannon FPA-5000ES2 step-and-scan exposure tool developed for the 150 nm generation lithography.

  8. 44 CFR 16.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...: Existing facilities. 16.150 Section 16.150 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT... accessibility: Existing facilities. (a) General. The agency shall operate each program or activity so that the... facilities accessible to and usable by individuals with handicaps; (2) In the case of historic preservation...

  9. 49 CFR 28.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Program accessibility: Existing facilities. 28.150....150 Program accessibility: Existing facilities. (a) General. The Department shall operate each program... Department to make each of its existing facilities accessible to and usable by individuals with handicaps; (2...

  10. 22 CFR 1600.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Program accessibility: Existing facilities. 1600.150 Section 1600.150 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP...

  11. 22 CFR 1600.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Program accessibility: Existing facilities. 1600.150 Section 1600.150 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP...

  12. 22 CFR 1600.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Program accessibility: Existing facilities. 1600.150 Section 1600.150 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP...

  13. 22 CFR 1600.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Program accessibility: Existing facilities. 1600.150 Section 1600.150 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP...

  14. 22 CFR 144.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....150 Section 144.150 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT OF... and usable by handicapped persons. This paragraph does not— (1) Necessarily require the agency to make...

  15. 22 CFR 144.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ....150 Section 144.150 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT OF... and usable by handicapped persons. This paragraph does not— (1) Necessarily require the agency to make...

  16. 22 CFR 1600.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Program accessibility: Existing facilities. 1600.150 Section 1600.150 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP...

  17. 33 CFR 150.616 - What are the requirements for lockout?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... lockout? 150.616 Section 150.616 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Lockout/tagout § 150.616 What are the requirements for lockout? The deepwater port operator must ensure that, if...

  18. 42 CFR 494.150 - Condition: Responsibilities of the medical director.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... 494.150 Section 494.150 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH... DISEASE FACILITIES Administration § 494.150 Condition: Responsibilities of the medical director. The... admissions, patient care, infection control, and safety are adhered to by all individuals who treat patients...

  19. 42 CFR 494.150 - Condition: Responsibilities of the medical director.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... 494.150 Section 494.150 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH... DISEASE FACILITIES Administration § 494.150 Condition: Responsibilities of the medical director. The... admissions, patient care, infection control, and safety are adhered to by all individuals who treat patients...

  20. 42 CFR 494.150 - Condition: Responsibilities of the medical director.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... 494.150 Section 494.150 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH... DISEASE FACILITIES Administration § 494.150 Condition: Responsibilities of the medical director. The... admissions, patient care, infection control, and safety are adhered to by all individuals who treat patients...

  1. AKAP150 mediates TRPV1 sensitivity to phosphatidylinositol-4, 5-bisphosphate

    PubMed Central

    Jeske, Nathaniel A.; Por, Elaine D.; Belugin, Sergei; Chaudhury, Sraboni; Berg, Kelly A.; Akopian, Armen N.; Henry, Michael A.; Gomez, Ruben

    2011-01-01

    A-kinase anchoring protein 150 (AKAP150) is a scaffolding protein that controls protein kinase A- and C-mediated phosphorylation of the transient receptor potential family V type 1 (TRPV1), dictating receptor response to nociceptive stimuli. The phospholipid phosphatidylinositol-4,5-bisphosphate (PIP2) anchors AKAP150 to the plasma membrane in naïve conditions, and also affects TRPV1 activity. In the present study, we sought to determine whether the effects of PIP2 on TRPV1 are mediated through AKAP150. In trigeminal neurons and CHO cells, the manipulation of cellular PIP2 led to significant changes in the association of AKAP150 and TRPV1. Following PIP2 degradation, increased TRPV1:AKAP150 co-immunoprecipitation was observed, resulting in increased receptor response to capsaicin treatment. Phospholipase C activation in neurons isolated from AKAP150−/− animals indicated that PIP2 -mediated inhibition of TRPV1 in the whole cell environment requires expression of the scaffolding protein. Furthermore, the addition of PIP2 to neurons isolated from AKAP150 wild-type mice reduced PKA-sensitization of TRPV1 compared to isolated neurons from AKAP150−/− mice. These findings suggest that PIP2 degradation increases AKAP150 association with TRPV1 in the whole cell environment, leading to sensitization of the receptor to nociceptive stimuli. PMID:21653872

  2. Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury.

    PubMed

    Ju, Peijun; Zhang, Si; Yeap, Yeeshan; Feng, Zhiwei

    2012-11-01

    Besides neural stem cells, some glial cells, such as GFAP+ cells, radial glia, and oligodendrocyte progenitor cells can produce neuronal cells. Attractively, NG2+ glial progenitors exhibit lineage plasticity, and they rapidly proliferate and differentiate in response to central nervous system (CNS) injuries. These attributes of NG2+ glial progenitors make them a promising source of neurons. However, the potential of neuronal regeneration from NG2+ glial progenitors in CNS pathologies remains to be investigated. In this study, we showed that antagonizing epidermal growth factor receptor (EGFR) function with EGFR inhibitor caused a significant number of proliferative NG2+ glial progenitors to acquire neuronal phenotypes in contusive spinal cord injury (SCI), which presumably led to an accumulation of newly generated neurons and contributed to the improved neural behavioral performance of animals. In addition, the neuronal differentiation of glial progenitors induced by EGFR inhibitor was further confirmed with two different cell lines either in vitro or through ex vivo transplantation experiment. The inhibition of EGFR signaling pathway under the gliogenic conditions could induce these cells to acquire neuronal phenotypes. Furthermore, we find that the Ras-ERK axis played a key role in neuronal differentiation of NG2+ glial progenitors upon EGFR inhibition. Taken together, our studies suggest that the EGFR inhibitor could promote neurogenesis post SCI, mainly from the NG2+ glial progenitors. These findings support the possibility of evoking endogenous neuronal replacement from NG2+ glial progenitors and suggest that EGFR inhibition may be beneficial to CNS trauma. Copyright © 2012 Wiley Periodicals, Inc.

  3. 22 CFR 1005.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Program accessibility: Existing facilities. 1005.150 Section 1005.150 Foreign Relations INTER-AMERICAN FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON... undertaken, such changes shall be made by August 22, 1989, but in any event as expeditiously as possible. (d...

  4. 10 CFR 72.150 - Instructions, procedures, and drawings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Instructions, procedures, and drawings. 72.150 Section 72... WASTE Quality Assurance § 72.150 Instructions, procedures, and drawings. The licensee, applicant for a... documented instructions, procedures, or drawings of a type appropriate to the circumstances and shall require...

  5. 21 CFR 173.150 - Milk-clotting enzymes, microbial.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Milk-clotting enzymes, microbial. 173.150 Section... HUMAN CONSUMPTION Enzyme Preparations and Microorganisms § 173.150 Milk-clotting enzymes, microbial. Milk-clotting enzyme produced by pure-culture fermentation process may be safely used in the production...

  6. 21 CFR 173.150 - Milk-clotting enzymes, microbial.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Milk-clotting enzymes, microbial. 173.150 Section... HUMAN CONSUMPTION Enzyme Preparations and Microorganisms § 173.150 Milk-clotting enzymes, microbial. Milk-clotting enzyme produced by pure-culture fermentation process may be safely used in the production...

  7. 21 CFR 173.150 - Milk-clotting enzymes, microbial.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Milk-clotting enzymes, microbial. 173.150 Section... (CONTINUED) SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Enzyme Preparations and Microorganisms § 173.150 Milk-clotting enzymes, microbial. Milk-clotting enzyme produced by pure-culture...

  8. 21 CFR 173.150 - Milk-clotting enzymes, microbial.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Milk-clotting enzymes, microbial. 173.150 Section... HUMAN CONSUMPTION Enzyme Preparations and Microorganisms § 173.150 Milk-clotting enzymes, microbial. Milk-clotting enzyme produced by pure-culture fermentation process may be safely used in the production...

  9. 33 CFR 150.830 - Reporting a pollution incident.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Reporting a pollution incident. 150.830 Section 150.830 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... pollution incident. Oil pollution incidents involving a deepwater port are reported according to §§ 135.305...

  10. 33 CFR 150.830 - Reporting a pollution incident.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Reporting a pollution incident. 150.830 Section 150.830 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... pollution incident. Oil pollution incidents involving a deepwater port are reported according to §§ 135.305...

  11. 33 CFR 150.830 - Reporting a pollution incident.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Reporting a pollution incident. 150.830 Section 150.830 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... pollution incident. Oil pollution incidents involving a deepwater port are reported according to §§ 135.305...

  12. 33 CFR 150.830 - Reporting a pollution incident.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Reporting a pollution incident. 150.830 Section 150.830 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... pollution incident. Oil pollution incidents involving a deepwater port are reported according to §§ 135.305...

  13. 33 CFR 150.830 - Reporting a pollution incident.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Reporting a pollution incident. 150.830 Section 150.830 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... pollution incident. Oil pollution incidents involving a deepwater port are reported according to §§ 135.305...

  14. Molecular mechanism of central nervous system repair by the Drosophila NG2 homologue kon-tiki.

    PubMed

    Losada-Perez, Maria; Harrison, Neale; Hidalgo, Alicia

    2016-08-29

    Neuron glia antigen 2 (NG2)-positive glia are repair cells that proliferate upon central nervous system (CNS) damage, promoting functional recovery. However, repair is limited because of the failure of the newly produced glial cells to differentiate. It is a key goal to discover how to regulate NG2 to enable glial proliferation and differentiation conducive to repair. Drosophila has an NG2 homologue called kon-tiki (kon), of unknown CNS function. We show that kon promotes repair and identify the underlying mechanism. Crush injury up-regulates kon expression downstream of Notch. Kon in turn induces glial proliferation and initiates glial differentiation by activating glial genes and prospero (pros). Two negative feedback loops with Notch and Pros allow Kon to drive the homeostatic regulation required for repair. By modulating Kon levels in glia, we could prevent or promote CNS repair. Thus, the functional links between Kon, Notch, and Pros are essential for, and can drive, repair. Analogous mechanisms could promote CNS repair in mammals. © 2016 Losada-Perez et al.

  15. Molecular mechanism of central nervous system repair by the Drosophila NG2 homologue kon-tiki

    PubMed Central

    Harrison, Neale

    2016-01-01

    Neuron glia antigen 2 (NG2)–positive glia are repair cells that proliferate upon central nervous system (CNS) damage, promoting functional recovery. However, repair is limited because of the failure of the newly produced glial cells to differentiate. It is a key goal to discover how to regulate NG2 to enable glial proliferation and differentiation conducive to repair. Drosophila has an NG2 homologue called kon-tiki (kon), of unknown CNS function. We show that kon promotes repair and identify the underlying mechanism. Crush injury up-regulates kon expression downstream of Notch. Kon in turn induces glial proliferation and initiates glial differentiation by activating glial genes and prospero (pros). Two negative feedback loops with Notch and Pros allow Kon to drive the homeostatic regulation required for repair. By modulating Kon levels in glia, we could prevent or promote CNS repair. Thus, the functional links between Kon, Notch, and Pros are essential for, and can drive, repair. Analogous mechanisms could promote CNS repair in mammals. PMID:27551055

  16. Attributing Methane and Carbon Dioxide Emissions from Anthropogenic and Natural Sources Using AVIRIS-NG

    NASA Astrophysics Data System (ADS)

    Thorpe, A. K.; Frankenberg, C.; Thompson, D. R.; Duren, R. M.; Aubrey, A. D.; Bue, B. D.; Green, R. O.; Gerilowski, K.; Krings, T.; Borchardt, J.; Kort, E. A.; Sweeney, C.; Conley, S. A.; Roberts, D. A.; Dennison, P. E.; Ayasse, A.

    2016-12-01

    Imaging spectrometers like the next generation Airborne Visible/Infrared Imaging Spectrometer (AVIRIS-NG) can map large regions with the high spatial resolution necessary to resolve methane (CH4) and carbon dioxide (CO2) emissions. This capability is aided by real time detection and geolocation of gas plumes, permitting unambiguous identification of individual emission source locations and communication to ground teams for rapid follow up. We present results from AVIRIS-NG flight campaigns in the Four Corners region (Colorado and New Mexico) and the San Joaquin Valley (California). Over three hundred plumes were observed, reflecting emissions from anthropogenic and natural sources. Examples of plumes will be shown for a number of sources, including CH4 from well completions, gas processing plants, tanks, pipeline leaks, natural seeps, and CO2 from power plants. Despite these promising results, an imaging spectrometer built exclusively for quantitative mapping of gas plumes would have improved sensitivity compared to AVIRIS-NG. For example, an instrument providing a 1 nm spectral sampling (2,000-2,400 micron) would permit mapping CH4, CO2, H2O, CO, and N2O from more diffuse sources using both airborne and orbital platforms. The ability to identify emission sources offers the potential to constrain regional greenhouse gas budgets and improve partitioning between anthropogenic and natural emission sources. Because the CH4 lifetime is only about 9 years and CH4 has a Global Warming Potential 86 times that of CO2 for a 20 year time interval, mitigating these emissions is a particularly cost-effective approach to reduce overall atmospheric radiative forcing. Fig. 1. True color image subset with superimposed gas plumes showing concentrations in ppmm. Left: AVIRIS-NG observed CH4 plumes from natural gas processing plant extending over 500 m downwind of multiple emissions sources. Right: Multiple CO2 plumes observed from coal-fired power plant.

  17. 14 CFR 135.150 - Public address and crewmember interphone systems.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... to alert flight crewmembers; (iii) For the alerting system required by paragraph (b)(7)(ii) of this... systems. 135.150 Section 135.150 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Aircraft and Equipment § 135.150 Public address and crewmember interphone systems. No person may operate an...

  18. 14 CFR 135.150 - Public address and crewmember interphone systems.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... to alert flight crewmembers; (iii) For the alerting system required by paragraph (b)(7)(ii) of this... systems. 135.150 Section 135.150 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Aircraft and Equipment § 135.150 Public address and crewmember interphone systems. No person may operate an...

  19. 14 CFR 135.150 - Public address and crewmember interphone systems.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... to alert flight crewmembers; (iii) For the alerting system required by paragraph (b)(7)(ii) of this... systems. 135.150 Section 135.150 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Aircraft and Equipment § 135.150 Public address and crewmember interphone systems. No person may operate an...

  20. 14 CFR 135.150 - Public address and crewmember interphone systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... to alert flight crewmembers; (iii) For the alerting system required by paragraph (b)(7)(ii) of this... systems. 135.150 Section 135.150 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Aircraft and Equipment § 135.150 Public address and crewmember interphone systems. No person may operate an...