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Sample records for ning lu laureano

  1. Block LU factorization

    NASA Technical Reports Server (NTRS)

    Demmel, James W.; Higham, Nicholas J.; Schreiber, Robert S.

    1992-01-01

    Many of the currently popular 'block algorithms' are scalar algorithms in which the operations have been grouped and reordered into matrix operations. One genuine block algorithm in practical use is block LU factorization, and this has recently been shown by Demmel and Higham to be unstable in general. It is shown here that block LU factorization is stable if A is block diagonally dominant by columns. Moreover, for a general matrix the level of instability in block LU factorization can be founded in terms of the condition number kappa(A) and the growth factor for Gaussian elimination without pivoting. A consequence is that block LU factorization is stable for a matrix A that is symmetric positive definite or point diagonally dominant by rows or columns as long as A is well-conditioned.

  2. Educators Eye Ning Transition to a Pay Model

    ERIC Educational Resources Information Center

    Davis, Michelle R.

    2010-01-01

    The author reports on a move by the online social-networking site Ning to start charging for its services which has raised worries that new fees could stifle educators' technological collaboration and creativity and touch off similar moves by other companies that provide comparable services heavily used by educators. Ning, which provides a…

  3. Atomic properties of Lu+

    NASA Astrophysics Data System (ADS)

    Paez, Eduardo; Arnold, K. J.; Hajiyev, Elnur; Porsev, S. G.; Dzuba, V. A.; Safronova, U. I.; Safronova, M. S.; Barrett, M. D.

    2016-04-01

    Singly ionized lutetium has recently been suggested as a potential clock candidate. Here we report a joint experimental and theoretical investigation of Lu+. Measurements relevant to practical clock operation are made and compared to atomic structure calculations. Calculations of scalar and tensor polarizabilities for clock states over a range of wavelengths are also given. These results will be useful for future work with this clock candidate.

  4. Beauty and physics: 13 important contributions of Chen Ning Yang

    NASA Astrophysics Data System (ADS)

    Shi, Yu

    2014-06-01

    In 2012, Chen Ning Yang received a 90th birthday gift in the form of a black cube inscribed with his 13 most important contributions, which cover four major areas of physics: statistical mechanics, condensed matter physics, particle physics and field theory. We briefly describe these 13 contributions and make general comments about Yang's distinctive style as a trailblazing leader in research.

  5. Social Networking in Physical Education: Undergraduate Students' Views on Ning

    ERIC Educational Resources Information Center

    Sezen Balcikanli, Gulfem

    2012-01-01

    It was the aim of this study to investigate physical education undergraduate students' views on the use of social networking, one of the most typical representations of Web 2.0 technologies. In order to do so, the researcher, who was the instructor of the class, entitled "Fair Play Education in Sport", introduced Ning and its educational aspects…

  6. Consequences of meta-stable (177m)Lu admixture in (177)Lu for patient dosimetry.

    PubMed

    Konijnenberg, Mark W

    2015-01-01

    Lutetium-177 ((177)Lu) is a rare earth metal in the lanthanides series which decays by beta emission with a half life of 6.647 days to three excited states and the ground state of (177)Hf. When (177)Lu is produced by neutron capture in (176)Lu, inevitably an admixture is formed of the long-lived isomer (177)mLu. As its half-life of 160.4 days is so much longer than that of (177)Lu, concerns are raised on its possible enhancement in radiation dose to the patient treated with (177)Lu-DOTA-octreotate. This report evaluates this possible enhancement of the absorbed dose, based on the published pharmacokinetic profile of (177)Lu-DOTA-octreotate and assuming an admixture of 1 kBq (177)mLu /MBq (177)Lu (0.1%).

  7. A diagonally inverted LU implicit multigrid scheme

    NASA Technical Reports Server (NTRS)

    Yokota, Jeffrey W.; Caughey, David A.; Chima, Rodrick V.

    1988-01-01

    A new Diagonally Inverted LU Implicit scheme is developed within the framework of the multigrid method for the 3-D unsteady Euler equations. The matrix systems that are to be inverted in the LU scheme are treated by local diagonalizing transformations that decouple them into systems of scalar equations. Unlike the Diagonalized ADI method, the time accuracy of the LU scheme is not reduced since the diagonalization procedure does not destroy time conservation. Even more importantly, this diagonalization significantly reduces the computational effort required to solve the LU approximation and therefore transforms it into a more efficient method of numerically solving the 3-D Euler equations.

  8. SuperLU users' guide

    SciTech Connect

    Demmel, James W.; Gilbert, John R.; Li, Xiaoye S.

    1999-11-01

    This document describes a collection of three related ANSI C subroutine libraries for solving sparse linear systems of equations AX = B: Here A is a square, nonsingular, n x n sparse matrix, and X and B are dense n x nrhs matrices, where nrhs is the number of right-hand sides and solution vectors. Matrix A need not be symmetric or definite; indeed, SuperLU is particularly appropriate for matrices with very unsymmetric structure. All three libraries use variations of Gaussian elimination optimized to take advantage both of sparsity and the computer architecture, in particular memory hierarchies (caches) and parallelism.

  9. jShyLU Scalable Hybrid Preconditioner and Solver

    2012-09-11

    ShyLU is numerical software to solve sparse linear systems of equations. ShyLU uses a hybrid direct-iterative Schur complement method, and may be used either as a preconditioner or as a solver. ShyLU is parallel and optimized for a single compute Solver node. ShyLU will be a package in the Trilinos software framework.

  10. THE LU ISOTOPIC COMPOSITION OF ACHONDRITES: CLOSING THE CASE FOR ACCELERATED DECAY OF {sup 176}LU

    SciTech Connect

    Wimpenny, Josh; Yin, Qing-zhu; Amelin, Yuri

    2015-10-10

    Studies of Lu–Hf isotope systematics in meteorites have produced apparent “ages” that are older than Pb–Pb ages and older than the estimated age of our solar system. One proposed explanation for this discrepancy is that irradiation by cosmic rays caused excitation of {sup 176}Lu to its short-lived isomer that then underwent rapid decay to {sup 176}Hf. This explanation can account for apparent excesses in {sup 176}Hf that correlate with Lu/Hf ratio. Mass balance requires that samples with measurable excess in {sup 176}Hf should also have measurable deficiencies in {sup 176}Lu on the order of 1‰–3‰. To unambiguously test the accelerated decay hypothesis, we have measured the {sup 176}Lu/{sup 175}Lu ratio in terrestrial materials and achondrites to search for evidence of depletion in {sup 176}Lu. To a precision of 0.1‰ terrestrial standards, cumulate and basaltic eucrites and angrites all have the same {sup 176}Lu/{sup 175}Lu ratio. Barring a subsequent mass-dependent fractionation event, these results suggest that the apparent excesses in {sup 176}Hf are not caused by accelerated decay of {sup 176}Lu, and so another hypothesis is required to explain apparently old Lu–Hf ages.

  11. Magnetic order in Dy/Lu superlattices

    NASA Astrophysics Data System (ADS)

    Beach, R. S.; Borchers, J. A.; Erwin, R. W.; Flynn, C. P.; Matheny, A.; Rhyne, J. J.; Salamon, M. B.

    1992-02-01

    Several superlattices containing alternate layers of the rare earth elements dysprosium and lutetium were grown by molecular beam epitaxy. Neutron diffraction shows that these samples develop a helical phase in the (≈40 Å) Dy layers at TN = 178 K which propagates coherently across the nonmagnetic Lu (20-55 Å thick). The Dy layers order ferromagnetically at temperatures which vary from 140 to 160 K (the ferromagnetic phase in the bulk material appears at 85 K). Below TC the ferromagnetic Dy layers may be either aligned or anti-aligned. The transition is accompanied by a distortion of the superlattice basal plane comparable to that which occurs in bulk Dy. We also observe an approximately 80 K increase in TC in thin Lu/Dy(< 150 Å)/Lu films. We discuss how the observed high TC may be related to the elastic coupling of the Dy to Lu.

  12. MueLu Multigrid Preconditioning Package

    2012-09-11

    MueLu is intended for the research and development of multigrid algorithms used in the solution of sparse linear systems arising from systems of partial differential equations. The software provides multigrid source code, test programs, and short example programs to demonstrate the various interfaces for creating, accessing, and applying the solvers. MueLu currently provides an implementation of smoothed aggregation algebraic multigrid method and interfaces to many commonly used smoothers. However, the software is intended to bemore » extensible, and new methods can be incorporated easily. MueLu also allows for advanced usage, such as combining multiple methods and segregated solves. The library supports point and block access to matrix data. All algorithms and methods in MueLu have been or will be published in the open scientific literature.« less

  13. Lu-177 preparation for radiotherapy application.

    PubMed

    Park, Ul Jae; Lee, Jun-Sig; Choi, Kang Hyuk; Nam, Sung Soo; Yu, Kook Hyun

    2016-09-01

    A separation study using a (176)Yb target for the preparation of nca (177)Lu, which is a beta-emitting nuclide used not only in radioimmunotherapy applications but also in the treatment of various lesions, has been performed. A material having a better selectivity and separation efficiency for Lu than Yb was developed, and the separation conditions of (177)Lu were derived using this from a neutron irradiated (176)Yb target. The separation material was an organo-ceramic hybrid material containing a phosphate group. Adsorption behavior was determined through batch experiments, and (177)Lu separation from the Yb target was evaluated through column experiments. The Yb target, with a 99.72% in (176)Yb, was irradiated in the irradiation hole of HANARO, which has a thermal neutron flux of 1.6E+14ncm(-2)s(-1). The batch experiments revealed that the organo-ceramic hybrid material (Sol-POS) had a separation factor of 1.6 at 0.5M HCl. Separation was performed through extraction chromatography using a 5mg enriched Yb target, and the separation yield of the NCA (177)Lu was about 78%. If the amount of Yb target is increased to produce curies level (177)Lu, additional purification will be needed. PMID:27295512

  14. Effect of Lu-to-Y ratio and Mo coactivation on scintillation properties of LuYAG:Pr and LuAG:Pr,Mo crystals

    NASA Astrophysics Data System (ADS)

    Drozdowski, W.; Brylew, K.; Witkowski, M. E.; Drewniak, A.; Masewicz, Z.; Wojtowicz, A. J.; Kisielewski, J.; Świrkowicz, M.

    2016-09-01

    In this paper the basic scintillation and thermoluminescence properties of LuYAG:Pr and LuAG:Pr,Mo crystals are reported. It is shown that, primarily, both materials display significantly higher scintillation yields than their prototype LuAG:Pr. The results of radioluminescence, low and high temperature thermoluminescence, and scintillation time profile measurements are analyzed quantitatively to allow us a better understanding of the scintillation process in LuYAG:Pr and LuAG:Pr,Mo, as well as to let us propose or verify possible explanations of the observed yield enhancement.

  15. Method for preparing high specific activity 177Lu

    SciTech Connect

    Mirzadeh, Saed; Du, Miting; Beets, Arnold L.; Knapp, Jr., Furn F.

    2004-04-06

    A method of separating lutetium from a solution containing Lu and Yb, particularly reactor-produced .sup.177 Lu and .sup.177 Yb, includes the steps of: providing a chromatographic separation apparatus containing LN resin; loading the apparatus with a solution containing Lu and Yb; and eluting the apparatus to chromatographically separate the Lu and the Yb in order to produce high-specific-activity .sup.177 Yb.

  16. Parallel execution of LU factorization: An analysis

    SciTech Connect

    Boreddy, J.; Paulraj, A.

    1990-02-01

    The authors consider LU factorization of dense matrices, and develop analytical models for execution on MIMD local memory systems. Both broadcast and nearest neighbor communication models are studied by quantifying computation, communication, and idle times. The performance modelling is validated through experimental results on a transputer array. The authors implemented three variants of LU factorization on a unidirectional ring: nearest neighbor communications with non-overlapped as well as overlapped communications, and broadcasting with pipelined data transfer. It has been found that broadcasting falls in between non-overlapped and overlapped nearest neighbor communications.

  17. Ionic liquid-based hydrothermal synthesis of Lu2O3 and Lu2O3:Eu3+ microcrysals

    NASA Astrophysics Data System (ADS)

    Li, Yinyan; Xu, Shiqing

    2016-09-01

    Uniform and well-defined Lu2O3 and Lu2O3:Eu3+ microarchitectures have been successfully synthesized via a green and facile ionic liquid-based hydrothermal method followed by a subsequent calcination process. Novel 3D micro-rodbundles and 1D microrods of Lu2O3 and Lu2O3:Eu3+ were controllably obtained through this method. X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy and photoluminescence spectra were used to characterize the micromaterials. The proposed formation mechanisms have been investigated on the basis of a series of SEM studies of the products obtained at different hydrothermal durations. The results indicated that hydrothermal temperature and the ionic liquid-tetrabutylammonium hydroxide were two key factors for the formation as well as the morphology control of the Lu2O3 and Lu2O3:Eu3+ microarchitectures.

  18. Estimated human absorbed dose of ¹⁷⁷Lu-BPAMD based on mice data: Comparison with ¹⁷⁷Lu-EDTMP.

    PubMed

    Yousefnia, Hassan; Zolghadri, Samaneh; Shanehsazzadeh, Saeed

    2015-10-01

    In this work, the absorbed dose of human organs for (177)Lu-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with (177)Lu-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both (177)Lu-BPAMD and (177)Lu-EDTMP is observed on the bone surface with 8.007 and 4.802 mSv/MBq. Generally, (177)Lu-BPAMD has considerable characteristics compared with (177)Lu-EDTMP and can be considered as a promising agent for the bone pain palliation therapy. PMID:26163291

  19. [Analysis on the ancient clinical application of Taiyuan (LU 9)].

    PubMed

    Mao, Gai; Jia, Hongling; Zhang, Yongchen

    2015-10-01

    The ancient literature on Taiyuan (LU 9) was collected to summarize the application laws of this acupoint. One thousand TCM ancient works collected in Chinese Medical Dictionary (fourth edition) were retrieved. The literature on the indications of Taiyuan (LU 9), the indications of Taiyuan (LU 9) combined prescriptions, the laws of acupoints combination and the techniques of acupuncture and moxibustion was collected systematically and the database was set up. It is found that there are 333 provisions in compliance with the inclusive standard of Taiyuan (LU 9), 306 provisions for the treatment of disorders and 66 relevant ancient works. There are 119 provisions relevant with the indication of single Taiyuan (LU 9) , 187 provisions for the applications of the combined prescriptions and 143 acupoints for the combined acupoints. Taiyuan (LU 9) and the combined prescriptions are applied to every department in clinic, especially for the disorders of TCM internal medicine department. The combined acupoints are distributed among the fourteen meridians and extra points and had been used totally for 1142 times. Of these points, there are 9 acupoints from the lung meridian of hand-taiyin and 25 acupoints from the bladder meridian of foot-taiyang, with the highest use frequency, 195 times and 141 times respectively, accounting for 17.08% and 12.35% of the total frequency. The common pairs of combination are Taiyuan (LU 9) and Yuji (LU 10), Taiyuan (LU 9) and Lieque (LU 7) and Taiyuan (LU 9) and Taibai (SP 3). The common dose of moxibustion at the acupoint is 3 cones. The depth of insertion is 0.2 cun and the acupuncture time is two breathes.

  20. [Analysis of algal blooms in Da-Ning River of Three Gorges Reservoir].

    PubMed

    Zheng, Bing-Hui; Cao, Cheng-Jin; Zhang, Jia-Lei; Huang, Min-Sheng; Chen, Zhen-Lou

    2009-11-01

    According to the survey conducted from Apr. to Jun. 2007 and from Apr. to May. 2008, the changes of water quality, forms and distributions of nutrient salts and characters of algal blooms in Da-ning River of Three Gorges Reservoir (TGR) were studied. The results indicated that the concentrations of nitrogen and phosphorus nutrient were abundant during sensitive period of algal blooms in Da-ning River. Total nitrogen (TN) and total phosphorus (TP) values are 0.84-3.21 mg/L and 0.011-0.531 mg/L respectively, and the nutrients concentrations become high gradually from upstream to downstream. Total dissolved nitrogen (TDN) is the major form of TN accounting for 84%, and total dissolved phosphorus (TDP) is dominant (TDP/TP = 60%). Algal blooms bring phosphorus nutrient bio-concentration. The rates of TN and TP are all in excess of 16, which show eutrophication is limited by phosphorus. Potassium permanganate index and dissolved oxygen (DO) are at low levels and change stably. But chlorophyll a (Chl-a) becomes frequently, the value is 1.41-219.04 mg x m(-3). Significant positive correlations are all observed by correlation analysis between Chl-a and the main parameters (r(Chla-TP) = 0.453, r(Chla-potassium permanganate index) = 0.641, r(Chla-DO) = 0.584, r(Chla-pH) = 0.409, p < 0.01), but significant negative correlations are observed between Chl-a and Secchi depth (SD) (r(Chla-SD) = - 0.392, p < 0.01). The pH is fluctuated by multiparameter esp. in algal blooms. Widespread algae are observed by microscope during sensitive period of algal blooms in Da-ning River accounting for 8 phylum 82 genus 124 species, which Bacillariophyta and Chlorophyta are dominant, and then Cyanophyta and Pyrrophyta. Three whole watershed algal blooms break out in Da-ning River during the period, and the highest values of algal density are 14-1 427 times as many as the normal values. The dominant species of algal blooms are mostly involved with O. borgei, C. microporum, Chlorococcum humicola, P

  1. Lu-Hf constraints on the evolution of lunar basalts

    SciTech Connect

    Fujimaki, H.; Tatsumoto, M.

    1984-02-15

    Very low Ti basalts andd green glass samples from the moon show high Lu/Hf ratios and low Hf concentrations. Low-Ti lunar basalts show high and variable Lu/Hf ratios and higher Hf concentrations, whereas high-Ti lunar basalts show low Lu/Hf ratios and high Hf concentrations. KREEP basalts have constant Lu/Hf ratios and high but variable Hf concentrations. Using the Lu-Hf behavior as a constraint, we propose a model for the mare basalts evolution. This constraint requires extensive crystallization of the primary lunar magma ocean prior to formation of the lunar mare basalt sources and the KREEP basalts. Mare basalts are produced by the melting of the cumulate rocks, and KREEP basalts represent the residual liquid of the magma ocean.

  2. Neutron Capture Reactions on lu Isotopes at Dance

    NASA Astrophysics Data System (ADS)

    Roig, O.; Meot, V.; Daugas, J.-M.; Morel, P.; Jandel, M.; Vieira, D. J.; Bond, E. M.; Bredeweg, T. A.; Couture, A. J.; Haight, R. C.; Keksis, A. L.; Rundberg, R. S.; Ullmann, J. L.; Wouters, J. M.

    2013-03-01

    The DANCE1 (Detector for Advanced Neutron Capture Experiments) array at LANSCE spallation neutron source in Los Alamos has been used to obtain the neutron radiative capture cross sections for 175Lu and 176Lu with neutron energies from thermal up to 100 keV. Both isotopes are of current interest for the nucleosynthesis s-process.2,3 Three targets were used to perform these measurements. One was natural Lu foil of 31 mg/cm2 and the other two were isotope-enriched targets of 175Lu and 176Lu. Firstly, the cross sections were obtained by normalizing yield to a well-known cross section at the thermal neutron energy. Now, we want to obtain absolute cross sections of radiative capture through a precise neutron flux determination, an accurate target mass measurement and an efficiency determination of the DANCE array.

  3. Neutron capture reactions on Lu isotopes at DANCE

    NASA Astrophysics Data System (ADS)

    Roig, O.; Jandel, M.; Vieira, D. J.; Bond, E. M.; Bredeweg, T. A.; Couture, A. J.; Daugas, J.-M.; Haight, R. C.; Keksis, A. L.; Méot, V.; Morel, P.; O'Donnell, J. M.; Rundberg, R. S.; Taylor, W. A.; Ullmann, J. L.; Wouters, J. M.

    2010-03-01

    The DANCE (Detector for Advanced Neutron Capture Experiments) array located at the Los Alamos national laboratory has been used to obtain the neutron capture cross sections for the 175Lu and 176Lu isotopes with neutron energies from thermal up to 100 keV. Both isotopes are of current interest for the nucleosynthesis s-process in astrophysics and for applications as in reactor physics or in nuclear medicine. Three targets were used to perform these measurements. One was natLu foil and the other two were isotope-enriched targets of 175Lu and 176Lu. The cross sections are obtained for now through a precise neutron flux determination and a normalization at the thermal neutron cross section value. A comparison with the recent experimental data and the evaluated data of ENDF/B-VII.0 will be presented. In addition, resonances parameters and spin assignments for some resonances will be featured.

  4. Growth and characterization of LuAs films and nanostructures

    NASA Astrophysics Data System (ADS)

    Krivoy, E. M.; Nair, H. P.; Crook, A. M.; Rahimi, S.; Maddox, S. J.; Salas, R.; Ferrer, D. A.; Dasika, V. D.; Akinwande, D.; Bank, S. R.

    2012-10-01

    We report the growth and characterization of nearly lattice-matched LuAs/GaAs heterostructures. Electrical conductivity, optical transmission, and reflectivity measurements of epitaxial LuAs films indicate that LuAs is semimetallic, with a room-temperature resistivity of 90 μΩ cm. Cross-sectional transmission electron microscopy confirms that LuAs nucleates as self-assembled nanoparticles, which can be overgrown with high-quality GaAs. The growth and material properties are very similar to those of the more established ErAs/GaAs system; however, we observe important differences in the magnitude and wavelength of the peak optical transparency, making LuAs superior for certain device applications, particularly for thick epitaxially embedded Ohmic contacts that are transparent in the near-IR telecommunications window around 1.3 μm.

  5. Growth and characterization of LuAs films and nanostructures

    SciTech Connect

    Krivoy, E. M.; Nair, H. P.; Crook, A. M.; Rahimi, S.; Maddox, S. J.; Salas, R.; Ferrer, D. A.; Dasika, V. D.; Akinwande, D.; Bank, S. R.

    2012-10-01

    We report the growth and characterization of nearly lattice-matched LuAs/GaAs heterostructures. Electrical conductivity, optical transmission, and reflectivity measurements of epitaxial LuAs films indicate that LuAs is semimetallic, with a room-temperature resistivity of 90 {mu}{Omega} cm. Cross-sectional transmission electron microscopy confirms that LuAs nucleates as self-assembled nanoparticles, which can be overgrown with high-quality GaAs. The growth and material properties are very similar to those of the more established ErAs/GaAs system; however, we observe important differences in the magnitude and wavelength of the peak optical transparency, making LuAs superior for certain device applications, particularly for thick epitaxially embedded Ohmic contacts that are transparent in the near-IR telecommunications window around 1.3 {mu}m.

  6. Dense LU Factorization on Multicore Supercomputer Nodes

    SciTech Connect

    Lifflander, Jonathan; Miller, Phil; Venkataraman, Ramprasad; Arya, Anshu; Jones, Terry R; Kale, Laxmikant V

    2012-01-01

    Dense LU factorization is a prominent benchmark used to rank the performance of supercomputers. Many implementations, including the reference code HPL, use block-cyclic distributions of matrix blocks onto a two-dimensional process grid. The process grid dimensions drive a trade-off between communication and computation and are architecture- and implementation-sensitive. We show how the critical panel factorization steps can be made less communication-bound by overlapping asynchronous collectives for pivot identification and exchange with the computation of rank-k updates. By shifting this trade-off, a modified block-cyclic distribution can beneficially exploit more available parallelism on the critical path, and reduce panel factorization's memory hierarchy contention on now-ubiquitous multi-core architectures. The missed parallelism in traditional block-cyclic distributions arises because active panel factorization, triangular solves, and subsequent broadcasts are spread over single process columns or rows (respectively) of the process grid. Increasing one dimension of the process grid decreases the number of distinct processes in the other dimension. To increase parallelism in both dimensions, periodic 'rotation' is applied to the process grid to recover the row-parallelism lost by a tall process grid. During active panel factorization, rank-1 updates stream through memory with minimal reuse. In a column-major process grid, the performance of this access pattern degrades as too many streaming processors contend for access to memory. A block-cyclic mapping in the more popular row-major order does not encounter this problem, but consequently sacrifices node and network locality in the critical pivoting steps. We introduce 'striding' to vary between the two extremes of row- and column-major process grids. As a test-bed for further mapping experiments, we describe a dense LU implementation that allows a block distribution to be defined as a general function of block

  7. High spin states in 162Lu

    NASA Astrophysics Data System (ADS)

    Gupta, S. L.; Pancholi, S. C.; Juneja, P.; Mehta, D.; Kumar, Ashok; Bhowmik, R. K.; Muralithar, S.; Rodrigues, G.; Singh, R. P.

    1997-09-01

    An experimental investigation of the odd-odd 162Lu nucleus, following the 148Sm(19F,5n) reaction at beam energy Elab=112 MeV, has been performed through in-beam gamma-ray spectroscopy. It revealed three signature-split bands. The yrast band based on πh11/2⊗νi13/2 configuration exhibits anomalous signature splitting (the unfavored signature Routhian lying lower than the favored one) whose magnitude Δe'~25 keV, is considerably reduced in contrast to sizable normal signature splitting Δe'~125 and 60 keV observed in the yrast πh11/2 bands of the neighboring odd-A 161,163Lu nuclei, respectively. The signature inversion in this band occurs at spin ~20ħ (frequency=0.37 MeV). The second signature-split band, observed above the band crossing associated with the alignment of a pair of i13/2 quasineutrons, is a band based on the four-quasiparticle [πh11/2[523]7/2-⊗νh9/2[521]3/2-⊗(νi13/2)2], i.e., EABAp(Bp), configuration. The third signature-split band is also likely to be a four-quasiparticle band with configuration similar to the second band but involving F quasineutron, i.e., FABAp(Bp). The experimental results are discussed in comparison with the existing data in the neighboring nuclei and in the framework of the cranking shell model.

  8. Geochemical test for branching decay of 176Lu

    NASA Astrophysics Data System (ADS)

    Amelin, Y.; Davis, W. J.

    2005-01-01

    Two different groups of values for the 176Lu decay constant have been determined by recent high-precision experiments. The λ 176Lu values of 1.86-1.87 × 10 -11 a -1 were determined by age comparisons using terrestrial minerals of Proterozoic and late Archean age, whereas values of ˜1.94 × 10 -11 a -1 were determined in age comparison studies of meteorites. A possible branched decay of 176Lu could be the cause of this discrepancy. The β + decay of 176Lu to 176Yb was detected in the early studies of radioactivity of 176Lu, with reported values of λβ +/(λβ + + λβ -) in the total 176Lu ranging from less than 0.03 to 0.67. If the β + decay fraction is close to the upper limit of the reported values, it can explain the 4%-6% difference between the apparent λ 176Lu values. To get a reliable estimate for the β + decay of 176Lu, we have measured Yb isotopic composition in 2.7 Ga zircons with Lu/Yb N (chondrite-normalized) ratios of 1.40 and 1.45, in 1.0 Ga xenotime with Lu/Yb N = 1.23, using Yb from the 28.4 Ma Fish Canyon Tuff (FCT) zircon and titanite as the modern reference value. Multiple analyses yielded the following weighted mean values (± 2σ) for the 176Yb/ 174Yb ratio: 0.4022134 ± 0.0000017 for the FCT zircon and titanite, 0.4022134 ± 0.0000019 for the 1.0 Ga xenotime, and 0.4022124 ± 0.0000033 for the 2.7 Ga zircons. These data yield λβ +/(λβ + + λβ -) = -0.005 ± 0.015 (2σ) and establish an upper limit of 0.9% of total decays for the β + decay branch. Branching decay can therefore be eliminated as the cause of the discrepancy in 176Lu decay constant estimates. We discuss other possible causes of the λ 176Lu terrestrial vs. meteorite discrepancy.

  9. Quasi four-level Tm:LuAG laser

    NASA Technical Reports Server (NTRS)

    Jani, Mahendra G. (Inventor); Barnes, Norman P. (Inventor); Hutcheson, Ralph L. (Inventor); Rodriguez, Waldo J. (Inventor)

    1997-01-01

    A quasi four-level solid-state laser is provided. A laser crystal is disposed in a laser cavity. The laser crystal has a LuAG-based host material doped to a final concentration between about 2% and about 7% thulium (Tm) ions. For the more heavily doped final concentrations, the LuAG-based host material is a LuAG seed crystal doped with a small concentration of Tm ions. Laser diode arrays are disposed transversely to the laser crystal for energizing the Tm ions.

  10. Spectroscopic and lasing properties of Ho:Tm:LuAG

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.; Filer, Elizabeth D.; Naranjo, Felipe L.; Rodriguez, Waldo J.; Kokta, Milan R.

    1993-01-01

    Ho:Tm:LuAG has been grown, examined spectroscopically, and lased at 2.1 microns. Ho:Tm:LuAG was selected for this experimental investigation when quantum-mechanical modeling predicted that it would be a good laser material for Ho laser operation on one of the 5I7 to 5I8 transitions. Lasing was achieved at 2.100 microns, one of the three wavelengths predicted to be most probable for laser action.

  11. Adhesive activity of Lu glycoproteins is regulated by interaction with spectrin

    SciTech Connect

    An, Xiuli; Gauthier, Emilie; Zhang, Xihui; Guo, Xinhua; Anstee, David; Mohandas, Narla; Anne Chasis, Joel

    2008-03-18

    The Lutheran (Lu) and Lu(v13) blood group glycoproteins function as receptors for extracellular matrix laminins. Lu and Lu(v13) are linked to the erythrocyte cytoskeleton through a direct interaction with spectrin. However, neither the molecular basis of the interaction nor its functional consequences have previously been delineated. In the present study, we defined the binding motifs of Lu and Lu(v13) on spectrin and identified a functional role for this interaction. We found that the cytoplasmic domains of both Lu and Lu(v13) bound to repeat 4 of the spectrin chain. The interaction of full-length spectrin dimer to Lu and Lu(v13) was inhibited by repeat 4 of {alpha}-spectrin. Further, resealing of this repeat peptide into erythrocytes led to weakened Lu-cytoskeleton interaction as demonstrated by increased detergent extractability of Lu. Importantly, disruption of the Lu-spectrin linkage was accompanied by enhanced cell adhesion to laminin. We conclude that the interaction of the Lu cytoplasmic tail with the cytoskeleton regulates its adhesive receptor function.

  12. Toward complete spectroscopy of 167Lu

    NASA Astrophysics Data System (ADS)

    Roux, D. G.; Ma, W. C.; Hagemann, G. B.; Amro, H.; Elema, D. R.; Fallon, P.; Görgen, A.; Herskind, B.; Hübel, H.; Li, Y.; Macchiavelli, A. O.; Marsh, J. C.; Sletten, G.; Ward, D.; Wilson, J. N.

    2015-12-01

    Excited states in 167Lu were populated in the 123Sb (48Ca ,4 n ) reaction at 203 MeV and decay γ rays measured using the Gammasphere spectrometer array. Two triaxial strongly deformed bands were identified previously and interpreted as zero- and one-phonon wobbling excitations. As a result of more extensive band search, the level scheme has been considerably extended to include ten new rotational bands and some 630 γ -ray transitions. A number of interband linking transitions were revealed, so that all but two bands could be connected with each other. Configurations are proposed for all new bands based on measured observables, with the help of cranked shell model calculations. A γ -ray sequence, previously suggested as a triaxial strongly deformed band based on quasiparticle excitations coexisting with the wobbling excitation in the triaxial potential well, has now been determined to be a signature partner of a coupled band, associated with a normal deformed five-quasiparticle configuration. The possibility of two new bands being associated with triaxial deformation is discussed.

  13. An Implicit LU/AF FDTD Method

    NASA Technical Reports Server (NTRS)

    Beggs, John H.; Briley, W. Roger

    2001-01-01

    There has been some recent work to develop two and three-dimensional alternating direction implicit (ADI) FDTD schemes. These ADI schemes are based upon the original ADI concept developed by Peaceman and Rachford and Douglas and Gunn, which is a popular solution method in Computational Fluid Dynamics (CFD). These ADI schemes work well and they require solution of a tridiagonal system of equations. A new approach proposed in this paper applies a LU/AF approximate factorization technique from CFD to Maxwell s equations in flux conservative form for one space dimension. The result is a scheme that will retain its unconditional stability in three space dimensions, but does not require the solution of tridiagonal systems. The theory for this new algorithm is outlined in a one-dimensional context for clarity. An extension to two and threedimensional cases is discussed. Results of Fourier analysis are discussed for both stability and dispersion/damping properties of the algorithm. Results are presented for a one-dimensional model problem, and the explicit FDTD algorithm is chosen as a convenient reference for comparison.

  14. [Healing current through a goiter. The life, work and after effects of the magic healer Bruno Gröning].

    PubMed

    Mildenberger, Florian

    2008-01-01

    During the years between 1949 and 1959 the wonder healer Bruno Gröning (1906-1959) gripped the public and medical interest in Germany. He explained to be a descent of Jesus Christ, sending "healing waves" to end diseases and made a lot of money. Finally he was found guilty in letting a persuaded fan dying and was convicted. But before the end of the process he died of carcinoma, which had been operated in a regular clinic. Despite this obvious problem that Gröning demanded from his admirers refusing medical help but preferred it for his own health today his successors are still promoting his legacy.

  15. LU-HF Age and Isotope Systematics of ALH84001

    NASA Technical Reports Server (NTRS)

    Righter, M.; Lapen, T. J.; Brandon, A. D.; Beard, B. L.; Shafer, J. T.; Peslier, A. H.

    2009-01-01

    Allan Hills (ALH) 84001 is an orthopyroxenite that is unique among the Martian meteorites in having the oldest inferred crystallization age (approx..4.5 to 4.0 Gyr) [e.g., 1-6 and references therein 7]. Its ancient origin makes this stone a critical constraint on early history of Mars, in particular the evolution of different planetary crust and mantle reservoirs. However, because there is significant variability in reported crystallization ages, determination of initial isotope compositions is imprecise making assessment of planetary reservoirs difficult. Here we report a new Lu-Hf mineral isochron age, initial Hf-176/Hf-177 isotope composition, and inferred Martian mantle source compositions for ALH84001 that place constraints on longlived source reservoirs for the enriched shergottite suite of Martian meteorites including Shergotty, Zagami, NWA4468, NWA856, RBT04262, LAR06319, and Los Angeles. Sm-Nd isotope analyses are under way for the same mineral aliquots analyzed for Lu-Hf. The Lu-Hf system was utilized because Lu and Hf are both lithophile and refractory and are not easily redistributed during short-lived thermal pulses associated with shock metamorphism. Moreover, chromite has relatively modest Hf concentrations with very low Lu/Hf ratios [9] yielding tight constraints on initial Hf-176/Hf-177 isotope compositions

  16. Fabrication and characterization of spark plasma sintered Ce:LuAG ceramic for scintillation application

    NASA Astrophysics Data System (ADS)

    Kumar, S. Arun; Senthilselvan, J.

    2016-05-01

    Rare earth Cerium doped Lutetium Aluminum Garnet (Ce:LuAG) ceramics are widely used as phosphor material in medical imaging and high-energy physics. Due to its technological importance, an attempt has been made to fabricate Ce:LuAG ceramics by using spark plasma sintering (SPS) technique. XRD patterns of SPS sintered Ce:LuAG ceramics reveals a mixed LuAG and CeO2 (antisite defect) phases. The microstructures of SPS sintered Ce:LuAG ceramics shows limited densification, inappropriate compaction of particles and existence of residual pores, voids between the grain boundaries affects the transparency of Ce:LuAG ceramics. Relative density and hardness of post sintered Ce:LuAG ceramic is also determined. The effect of Ce3+ doping concentration and sintering temperature on optical luminescence behavior of Ce:LuAG ceramic is presented.

  17. Reanalysis of the Lukeino molar (KNM-LU 335).

    PubMed

    Ungar, P S; Walker, A; Coffing, K

    1994-06-01

    This paper details a reanalysis of KNM-LU 335, a hominoid mandibular first molar dated to about 6 Ma from the Lukeino Formation, Kenya. Researchers have argued that this molar closely resembles those of modern chimpanzees and may approximate the ancestral morphotype of humans and chimpanzees. The investigation presented here describes a morphometric study of the Lukeino molar and M1s of Homo sapiens, Pan troglodytes, and early australopithecines. Results indicate that KNM-LU 335 differs from both human and chimpanzee M1s in relative distances (measured in three dimensions) between crown fissure termini. Further, the Lukeino molar shares with early australopithecines a pronounced flaring of the buccal surface of the crown not seen for either modern sample. Results of this study do not exclude KNM-LU 335 as a potential ancestral morphotype for Pan and Homo but provide no evidence that this morphotype resembled modern chimpanzees. PMID:8085609

  18. Radiative neutron capture cross sections on 176Lu at DANCE

    NASA Astrophysics Data System (ADS)

    Roig, O.; Jandel, M.; Méot, V.; Bond, E. M.; Bredeweg, T. A.; Couture, A. J.; Haight, R. C.; Keksis, A. L.; Rundberg, R. S.; Ullmann, J. L.; Vieira, D. J.

    2016-03-01

    The cross section of the neutron capture reaction 176Lu(n ,γ ) has been measured for a wide incident neutron energy range with the Detector for Advanced Neutron Capture Experiments at the Los Alamos Neutron Science Center. The thermal neutron capture cross section was determined to be (1912 ±132 ) b for one of the Lu natural isotopes, 176Lu. The resonance part was measured and compared to the Mughabghab's atlas using the R -matrix code, sammy. At higher neutron energies the measured cross sections are compared to ENDF/B-VII.1, JEFF-3.2, and BRC evaluated nuclear data. The Maxwellian averaged cross sections in a stellar plasma for thermal energies between 5 keV and 100 keV were extracted using these data.

  19. Reanalysis of the Lukeino molar (KNM-LU 335).

    PubMed

    Ungar, P S; Walker, A; Coffing, K

    1994-06-01

    This paper details a reanalysis of KNM-LU 335, a hominoid mandibular first molar dated to about 6 Ma from the Lukeino Formation, Kenya. Researchers have argued that this molar closely resembles those of modern chimpanzees and may approximate the ancestral morphotype of humans and chimpanzees. The investigation presented here describes a morphometric study of the Lukeino molar and M1s of Homo sapiens, Pan troglodytes, and early australopithecines. Results indicate that KNM-LU 335 differs from both human and chimpanzee M1s in relative distances (measured in three dimensions) between crown fissure termini. Further, the Lukeino molar shares with early australopithecines a pronounced flaring of the buccal surface of the crown not seen for either modern sample. Results of this study do not exclude KNM-LU 335 as a potential ancestral morphotype for Pan and Homo but provide no evidence that this morphotype resembled modern chimpanzees.

  20. Lu-Hf constraints on the evolution of lunar basalts

    NASA Technical Reports Server (NTRS)

    Fujimaki, H.; Tatsumoto, M.

    1984-01-01

    It is shown that a cumulate-remelting model best explains the recently acquired data on the Lu-Hf systematics of lunar mare basalts. The model is constructed using Lu and Hf concentration data and is strengthened by Hf isotopic evidence of Unruh et al. (1984). It is shown that the similarity in MgO/FeO ratios and Cr2O3 content in high-Ti and low-Ti basalts are not important constraints on lunar basalt petrogenesis. The model demonstrates that even the very low Ti or green glass samples are remelting products of a cumulate formed after at least 80-90 percent of the lunar magma ocean had solidified. In the model, all the mare basalts and green glasses were derived from 100-150 km depth in the lunar mantle. The Lu-Hf systematics of KREEP basalts clearly indicate that they would be the final residual liquid of the lunar magma ocean.

  1. An overview of SuperLU: Algorithms, implementation, and userinterface

    SciTech Connect

    Li, Xiaoye S.

    2003-09-30

    We give an overview of the algorithms, design philosophy,and implementation techniques in the software SuperLU, for solving sparseunsymmetric linear systems. In particular, we highlight the differencesbetween the sequential SuperLU (including its multithreaded extension)and parallel SuperLU_DIST. These include the numerical pivoting strategy,the ordering strategy for preserving sparsity, the ordering in which theupdating tasks are performed, the numerical kernel, and theparallelization strategy. Because of the scalability concern, theparallel code is drastically different from the sequential one. Wedescribe the user interfaces ofthe libraries, and illustrate how to usethe libraries most efficiently depending on some matrix characteristics.Finally, we give some examples of how the solver has been used inlarge-scale scientific applications, and the performance.

  2. Bu-Shen-Ning-Xin decoction suppresses osteoclastogenesis via increasing dehydroepiandrosterone to prevent postmenopausal osteoporosis.

    PubMed

    Gui, Yuyan; Qiu, Xuemin; Xu, Yingping; Li, Dajin; Wang, Ling

    2015-06-01

    Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in vitro because of the critical roles of bone resorption in the development and progression of osteoporosis. In mice, serum levels of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and 17-β-estradiol (E2) were evaluated with an enzyme immunoassay kit after ovariectomy. Levels of DHEA and DHEAS increased significantly following administration of BSNXD while the level of E2 did not. In addition, tartrate-resistance acid phosphatase staining showed that DHEA profoundly inhibited RANKL-induced osteoclastogenesis in vitro in a dose-dependent manner via estrogen receptor α (ERα) but not via estrogen receptor β or androgen receptors. Cytotoxicity was not detected in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. These data suggest that BSNXD prevents PMO by increasing DHEA via the ERαpathway to suppress osteoclastogenesis.

  3. ^176Lu/^175Lu thermometry for Oklo natural reactors: a new look at old data

    NASA Astrophysics Data System (ADS)

    Gould, Chris; Sharapov, Eduard

    2012-03-01

    Lutetium thermometry has been used to analyze Oklo natural nuclear reactor zones but leads to widely varying and puzzling predictions for the temperatures TO, which in turn impacts Oklo bounds on the time variation of the fine structure constant α. We revisit results for reactor zone RZ10 in light of new astrophysical measurements of the isomer branching ratio B^g in ^175Lu neutron capture at 5 and 25 keV. We recalculate predictions for TO as a function of B^g using realistic models of the Oklo neutron flux. We find TO= 100 ±30 C using a new value of B^g, in contrast to 350 < TO< 500 C using the evaluated value at thermal energy. Lutetium thermometry can be applicable to analyses of Oklo reactor data, but a better measurement of B^g with thermal neutrons is needed to confirm the reliability of temperature predictions.

  4. 176Lu/175Lu thermometry for the Oklo natural reactors: A new examination of old data

    NASA Astrophysics Data System (ADS)

    Gould, C. R.; Sharapov, E. I.

    2012-02-01

    Background: Lutetium thermometry has been used to analyze Oklo natural nuclear reactor zones but leads to widely varying and puzzling predictions for the temperatures TO which in turn impacts bounds on time variation of the fine structure constant α.Purpose: We revisit results for reactor zone RZ10 in light of new measurements of the isomer branching ratio Bg in 175Lu neutron capture at 5 and 25 keV.Method: We recalculate predictions for TO as a function of Bg using realistic models of the Oklo neutron flux.Results: We find TO=100±30 ∘C using a new value of Bg, in contrast to 350

  5. Intermediate States in the Photoexcitation of 176mLu

    NASA Astrophysics Data System (ADS)

    Carroll, J. J.; Henry, T.; Balint, T.; Pitz, H.-H.; Stedile, F.; Kneissl, U.

    2011-10-01

    The photoexcitation of 176mLu has been studied experimentally using the high-intensity DYNAMITRON accelerator at the University of Stuttgart. Enriched samples of 176Lu (72.5%) were irradiated with bremsstrahlung having endpoint energies between 700 - 2,200 keV. Several intermediate states were identified by which the 3.64 hour isomer was populated, and their energy-integrated cross sections were measured. The results and implications for stellar nucleosynthesis of this odd-odd nuclide will be discussed. Supported in part by DTRA grant HDTRA1-08-1-0014.

  6. STS-106 Mission Specialist Lu suits up before launch

    NASA Technical Reports Server (NTRS)

    2000-01-01

    STS-106 Mission Specialist Edward T. Lu smiles as he gets suited up in the Operations and Checkout Building before launch. This is Lu'''s second space flight. Space Shuttle Atlantis is set to lift off 8:45 a.m. EDT on the fourth flight to the International Space Station. During the 11-day mission, the seven-member crew will perform support tasks on orbit, transfer supplies and prepare the living quarters in the newly arrived Zvezda Service Module. The first long-duration crew, dubbed '''Expedition One,''' is due to arrive at the Station in late fall.

  7. [Experience of LU Zhi-zheng to apply tenuifolia].

    PubMed

    Wang, Qiu-feng; Liu, Zong-lian; Lu, Jie

    2015-10-01

    Professor LU Zhi-zheng, one of the first traditional Chinese medicine masters, is good at using tenuifoliain clinical practice, which often brings unexpected surprises. Lu said, tenuifolia is a mild herbal medicine with the nature of upward dispersion and outward penetration but not dryness. Tenuifolia has the following functions: making people conscious, relieving sore throat, diverging incubated diseases, regulating functional activities of qi, sending up Yang, dispelling wind evil and eliminating dampness, and activating collaterals to relieve pain. When well used, it will not only enhance the effect of monarch drug, but also restrict the impetuosity nature in a prescription, achieving better efficacy. PMID:26975116

  8. Room-Temperature Multiferroic Hexagonal LuFeO3

    SciTech Connect

    Cheng, Xuemei; Balke, Nina; Chi, Miaofang; Gai, Zheng; Keavney, David; Lee, Ho Nyung; Shen, Jian; Snijders, Paul C; Wang, Wenbin; Ward, Thomas Z; Xu, Xiaoshan; Yi, Jieyu; Zhu, Leyi; Christen, Hans M; Zhao, Jun

    2013-01-01

    We observed the coexistence of ferroelectricity and weak ferromagnetism at room temperature in the hexagonal phase of LuFeO3 stabilized by epitaxial thin film growth. While the ferroelectricity in hexagonal LuFeO3 can be understood as arising from its polar structure, the observation of weak ferromagnetism at room temperature is remarkable considering the frustrated triangular spin structure. An explanation of the room temperature weak ferromagnetism is proposed in terms of a subtle lattice distortion revealed by the structural characterization. The combination of ferroelectricity and weak ferromagnetism in epitaxial films at room temperature offers great potential for the application of this novel multiferroic material in next generation devices.

  9. Performance analysis of parallel supernodal sparse LU factorization

    SciTech Connect

    Grigori, Laura; Li, Xiaoye S.

    2004-02-05

    We investigate performance characteristics for the LU factorization of large matrices with various sparsity patterns. We consider supernodal right-looking parallel factorization on a bi-dimensional grid of processors, making use of static pivoting. We develop a performance model and we validate it using the implementation in SuperLU-DIST, the real matrices and the IBM Power3 machine at NERSC. We use this model to obtain performance bounds on parallel computers, to perform scalability analysis and to identify performance bottlenecks. We also discuss the role of load balance and data distribution in this approach.

  10. Home Education of a Bright Student: A Case Study on Lu Wei

    ERIC Educational Resources Information Center

    Yuexiang, Chen; Hongfang, Zhou

    2006-01-01

    In this article, the authors explore the life history and home education of Lu Wei, a top student in the 2004 Guangdong Province College entrance examination. The authors argue that the following issues of Lu's home education played an important role in Lu's success: emphasis and nurture of intellectual development in the early years of life,…

  11. Quantitative trait loci for yield and related traits in the wheat population Ning7840 x Clark.

    PubMed

    Marza, F; Bai, G-H; Carver, B F; Zhou, W-C

    2006-02-01

    Grain yield and associated agronomic traits are important factors in wheat (Triticum aestivum L.) improvement. Knowledge regarding the number, genomic location, and effect of quantitative trait loci (QTL) would facilitate marker-assisted selection and the development of cultivars with desirable characteristics. Our objectives were to identify QTLs directly and indirectly affecting grain yield expression. A population of 132 F12 recombinant inbred lines (RILs) was derived by single-seed descent from a cross between the Chinese facultative wheat Ning7840 and the US soft red winter wheat Clark. Phenotypic data were collected for 15 yield and other agronomic traits in the RILs and parental lines from three locations in Oklahoma from 2001 to 2003. Twenty-nine linkage groups, consisting of 363 AFLP and 47 SSR markers, were identified. Using composite interval mapping (CIM) analysis, 10, 16, 30, and 14 QTLs were detected for yield, yield components, plant adaptation (shattering and lodging resistance, heading date, and plant height), and spike morphology traits, respectively. The QTL effects ranged from 7 to 23%. Marker alleles from Clark were associated with a positive effect for the majority of QTLs for yield and yield components, but gene dispersion was the rule rather than the exception for this RIL population. Often, QTLs were detected in proximal positions for different traits. Consistent, co-localized QTLs were identified in linkage groups 1AL, 1B, 4B, 5A, 6A, and 7A, and less consistent but unique QTLs were identified on 2BL, 2BS, 2DL, and 6B. Results of this study provide a benchmark for future efforts on QTL identification for yield traits. PMID:16369760

  12. Conductively Cooled Ho:Tm:LuLiF Laser Amplifier

    NASA Technical Reports Server (NTRS)

    Bai, Yingxin; Yu, Jirong; Trieu, Bo; Petros, M.; Petzar, Paul; Lee, Hyung; Singh, U.

    2008-01-01

    A conductively-cooled Ho:Tm:LuLiF laser head can amplify 80mJ/340ns probe pulses into 400mJ when the pump pulse energy is close to amplified spontaneous emission (ASE) threshold, 5.6J. For a small signal, the double-pass amplification exceeds 25.

  13. ASASSN-15lu is a Type Ia Supernova

    NASA Astrophysics Data System (ADS)

    Leonard, D. C.; Sheehan, P.; McCarthy, D.; Follette, K.; Moustakas, J.; Cantillo, D.; Cazares-Kelly, A.; Cazares-Kelly, S.; Cendes, Y.; Damm, N.; Donati, A.; Douglas, E.; Ferrell, L.; Fosbiner-Elkins, H.; Fox, C.; Greenberg, M.; Hart, K.; Hensley, H.; Holt, A.; Hooper, E.; Juran, C.; Keane, J.; Key, K.; Korus, L.; Lee, T.; Leidig, K.; Merchak, E.; Nessmann, K.; Pendyala, S.; Pirkl, S.; Reeder, J.; Roos, A.; Rounseville, S.; Ruddy, E.; Schlingman, A.; Schlingman, W.; Schlingman, W.; Schwartzman, E.; Shanmugam, V.; Silver, E.; Stein, A.; Stock, N.; Svoboda, B.; Thomas, B.; Thomas, N.; Thompson-Taylor, K.; Walton, H.

    2015-06-01

    We report spectroscopic classification of ASASSN-15lu (ATel #7698) in SDSS J132112.88+401556.7 (z=0.035037, via NED) through inspection of an optical spectrum (range 370-680 nm, resolution 0.8 nm), obtained with the 2.3-m Bok telescope (+ Boller & Chivens spectrograph) at Kitt Peak on 2015 June 24.2 UT.

  14. Optimization of irradiation conditions for {sup 177}Lu production at the LVR-15 research reactor

    SciTech Connect

    Lahodova, Z.; Viererbl, L.; Klupak, V.; Srank, J.

    2012-07-01

    The use of lutetium in medicine has been increasing over the last few years. The {sup 177}Lu radionuclide is commercially available for research and test purposes as a diagnostic and radiotherapy agent in the treatment of several malignant tumours. The yield of {sup 177}Lu from the {sup 176}Lu(n,{gamma}){sup 177}Lu nuclear reaction depends significantly on the thermal neutron fluence rate. The capture cross-sections of both reaction {sup 176}Lu(n,{gamma}){sup 177}Lu and reaction {sup 177}Lu(n,{gamma}){sup 178}Lu are very high. Therefore a burn-up of target and product nuclides should be taken into account when calculating {sup 177}Lu activity. The maximum irradiation time, when the activity of the {sup 177}Lu radionuclide begins to decline, was found for different fluence rates. Two vertical irradiation channels at the LVR-15 nuclear research reactor were compared in order to choose the channel with better irradiation conditions, such as a higher thermal neutron fluence rate in the irradiation volume. In this experiment, lutetium was irradiated in a titanium capsule. The influence of the Ti capsule on the neutron spectrum was monitored using activation detectors. The choice of detectors was based on requirements for irradiation time and accurate determination of thermal neutrons. The following activation detectors were selected for measurement of the neutron spectrum: Ti, Fe, Ni, Co, Ag and W. (authors)

  15. Lu-Hf and PbSL geochronology of apatites from Proterozoic terranes: A first look at Lu-Hf isotopic closure in metamorphic apatite

    NASA Astrophysics Data System (ADS)

    Barfod, Gry Hoffmann; Krogstad, Eirik Jens; Frei, Robert; Albarède, Francis

    2005-04-01

    The mineral apatite is characterized by elevated and highly variable Lu/Hf ratios that, in some cases, allow for single-crystal dating by the Lu-Hf isotopic system. Apatites from the Adirondack Lowlands and Otter Lake area in the Grenville Province, and from the Black Hills, South Dakota, yield Lu-Hf ages that are consistently older than their respective Pb step leaching ages. Isotopic closure for the Lu-Hf system, therefore, occurs before U-Pb system closure in this mineral. In the Adirondack Lowlands, where H 2O activity was low, Lu-Hf systematics of cm-sized apatite crystals remained undisturbed during upper amphibolite facies metamorphism (˜700 to 675 °C) at 1170-1130 Ma. The relatively old Lu-Hf ages of 1270 and 1230 Ma observed for these apatites correlate with decreasing crystal size. In contrast, apatite from the fluid-rich Otter Lake area and Black Hills yields unrealistically low apparent Lu-Hf closure temperatures, implying that in these apatites, fluids facilitated late exchange. The Lu-Hf ages for the metamorphic apatites were thus controlled either by the prevailing temperature and grain size, or by fluid activity.

  16. First photometric study of W UMa binary star LU Lac

    NASA Astrophysics Data System (ADS)

    Liao, W.-P.; Qian, S.-B.; Zhao, E.-G.; Jiang, L.-Q.

    2014-08-01

    LU Lac is a neglected W UMa binary star in photometric investigations. In this paper, we present BVRI CCD photometric light curves obtained on one night in 2012. The first photometric solutions of this system are computed by using the Wilson-Devinney code. It is shown that LU Lac is a marginal contact W-type system with a degree of contact factor of f=8.9%, a mass ratio of q=2.085 and a high inclination of i=82°.20. From the first analyses of orbital period changes, we found the period variation of the system includes an oscillation (A3=0.0125 days and T3=51.92 years). The cyclic change may be attributed to the light-travel time effect through the presence of a third body.

  17. Lattice dynamics of LuPO{sub 4}

    SciTech Connect

    Nipko, J.C. |; Loong, C.-K.; Loewenhaupt, M.; Reichardt, W.; Braden, M.; Boatner, L.A.

    1996-06-01

    Lutetium orthophosphate is an important nonmagnetic host material for rare-earth-activated luminescence applications. We have measured the LuPO{sub 4} phonon density of states and dispersion curves along the [{xi}00],[{xi}{xi}0], and [00{xi}] symmetry directions by neutron spectroscopy using polycrystalline and single-crystal samples. A quantitative analysis of the neutron results was carried out using a lattice-dynamical shell model.

  18. Flashlamp-pumped Ho:Tm:Cr:LuAG laser

    NASA Technical Reports Server (NTRS)

    Jani, Mahendra G. (Inventor); Barnes, Norman P. (Inventor); Murray, Keith E. (Inventor); Kokta, Milan R. (Inventor)

    1997-01-01

    A room temperature solid-state laser is provided. A laser crystal is disposed in a laser cavity. The laser crystal has a LuAG host material doped with a concentration of about 0.35% Ho ions, about 5.57% Tm ions and at least about 1.01% Cr ions. A broadband energizing source such as a flashlamp is disposed transversely to the laser crystal to energize the Ho ions, Tm ions and Cr ions.

  19. Shape evolution with angular momentum in Lu isotopes

    NASA Astrophysics Data System (ADS)

    Kardan, Azam; Sayyah, Sepideh

    2016-06-01

    The nuclear potential energies of Lu isotopes with neutron number N = 90 ‑ 98 up to high spins are computed within the framework of the unpaired cranked Nilsson-Strutinsky method. The potential and the macroscopic Lublin-Strasbourg drop (LSD) energy-surface diagrams are analyzed in terms of quadrupole deformation and triaxiality parameter. The shape evolution of these isotopes with respect to angular momentum, as well as the neutron number is studied.

  20. Shape evolution with angular momentum in Lu isotopes

    NASA Astrophysics Data System (ADS)

    Kardan, Azam; Sayyah, Sepideh

    2016-06-01

    The nuclear potential energies of Lu isotopes with neutron number N = 90 - 98 up to high spins are computed within the framework of the unpaired cranked Nilsson-Strutinsky method. The potential and the macroscopic Lublin-Strasbourg drop (LSD) energy-surface diagrams are analyzed in terms of quadrupole deformation and triaxiality parameter. The shape evolution of these isotopes with respect to angular momentum, as well as the neutron number is studied.

  1. Automatic Blocking Of QR and LU Factorizations for Locality

    SciTech Connect

    Yi, Q; Kennedy, K; You, H; Seymour, K; Dongarra, J

    2004-03-26

    QR and LU factorizations for dense matrices are important linear algebra computations that are widely used in scientific applications. To efficiently perform these computations on modern computers, the factorization algorithms need to be blocked when operating on large matrices to effectively exploit the deep cache hierarchy prevalent in today's computer memory systems. Because both QR (based on Householder transformations) and LU factorization algorithms contain complex loop structures, few compilers can fully automate the blocking of these algorithms. Though linear algebra libraries such as LAPACK provides manually blocked implementations of these algorithms, by automatically generating blocked versions of the computations, more benefit can be gained such as automatic adaptation of different blocking strategies. This paper demonstrates how to apply an aggressive loop transformation technique, dependence hoisting, to produce efficient blockings for both QR and LU with partial pivoting. We present different blocking strategies that can be generated by our optimizer and compare the performance of auto-blocked versions with manually tuned versions in LAPACK, both using reference BLAS, ATLAS BLAS and native BLAS specially tuned for the underlying machine architectures.

  2. 177Lu-labeled Gold Nanoparticles for Radiation Therapy of Locally Advanced Breast Cancer

    NASA Astrophysics Data System (ADS)

    Yook, Simmyung

    Locally advanced breast cancer (LABC) occurs in about 10-15% of patients diagnosed with breast cancer (BC) and 30% of these patients have triple negative breast cancer (TNBC) that are often epidermal growth factor receptor (EGFR)-positive. The goal of the proposed research was design and evaluate preclinically a novel radiation nanomedicine for LABC composed of EGFR-targeted gold nanoparticles (AuNP) by covalently conjugating panitumumab and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) complexing 177Lu incorporated into a metal-chelating polymer (MCP) (177 Lu-T-AuNP) which could be used as a neoadjuvant treatment to improve the outcome of patients with LABC. 177Lu-T-AuNP were efficiently internalized by EGFR-positive BC cells and were significantly more effective than 177Lu-labeled and non-targeted (NT)-AuNP for killing these cells. For radiation treatment of EGFR-positive tumours, both 177Lu-T-AuNP and 177Lu-NT-AuNP were intratumourally (i.t.) injected into athymic mice with MDA-MB-468 BC xenografts for comparison. Biodistribution studies showed that 177Lu-T-AuNPs exhibited 2-fold higher tumour retention than 177Lu-NT-AuNPs following i.t. injection at 48 h p.i. Both forms of radiolabeled AuNP were highly effective for inhibiting tumour growth without normal organ toxicity due to local tumour retention of both form of AuNP. To minimize the displacement of 177Lu-labeled MCP from AuNP, polyethylene glycol (PEG) ligands presenting a disulfide [ 177Lu-DOTA-PEG-ortho-pyridyl disulfide (OPSS)], a lipoic acid (LA) [177Lu-DOTA-PEG-lipoic acid (LA)] or multi-LA [PEG- pGlu(177Lu-DOTA)8-LA4] for multivalent binding were synthesized and the stability of MCP-AuNP complexes determined. In vitro challenge study with thiol-containing molecules or human plasma, PEG-pGlu(DOTA)8-LA4-AuNP were most stable. In whole body elimination study, elimination of radioactivity due to displacement of 177Lu-MCP from AuNP in mice injected with 177Lu-DOTA-PEG-OPSS-AuNP was more

  3. Cryptococcose neuroméningée et tuberculose osseuse chez un immunocompétent: un cas

    PubMed Central

    Gbané-Koné, Mariam; Ouali, Boubacar; Mègne, Estelle; Diomandé, Mohamed; Coulibaly, Abidou Kawalé; Eti, Edmond; Kouakou, N'zué Marcel

    2015-01-01

    Les auteurs rapportent un cas de cryptococcose neuroméningée (CNM) chez un patient de 39 ans, non infecté par le VIH suivi pour une tuberculose de hanche. Le tableau clinique était celui d'une méningite subaiguë. Le diagnostic a été possible grâce à la mise en évidence de cryptocoques dans le LCR. L’évolution a été satisfaisante sous fluconazole. PMID:26090057

  4. LuIII parvovirus selectively and efficiently targets, replicates in, and kills human glioma cells.

    PubMed

    Paglino, Justin C; Ozduman, Koray; van den Pol, Anthony N

    2012-07-01

    Because productive infection by parvoviruses requires cell division and is enhanced by oncogenic transformation, some parvoviruses may have potential utility in killing cancer cells. To identify the parvovirus(es) with the optimal oncolytic effect against human glioblastomas, we screened 12 parvoviruses at a high multiplicity of infection (MOI). MVMi, MVMc, MVM-G17, tumor virus X (TVX), canine parvovirus (CPV), porcine parvovirus (PPV), rat parvovirus 1A (RPV1A), and H-3 were relatively ineffective. The four viruses with the greatest oncolytic activity, LuIII, H-1, MVMp, and MVM-G52, were tested for the ability, at a low MOI, to progressively infect the culture over time, causing cell death at a rate higher than that of cell proliferation. LuIII alone was effective in all five human glioblastomas tested. H-1 progressively infected only two of five; MVMp and MVM-G52 were ineffective in all five. To investigate the underlying mechanism of LuIII's phenotype, we used recombinant parvoviruses with the LuIII capsid replacing the MVMp capsid or with molecular alteration of the P4 promoter. The LuIII capsid enhanced efficient replication and oncolysis in MO59J gliomas cells; other gliomas tested required the entire LuIII genome to exhibit enhanced infection. LuIII selectively infected glioma cells over normal glial cells in vitro. In mouse models, human glioblastoma xenografts were selectively infected by LuIII when administered intratumorally; LuIII reduced tumor growth by 75%. LuIII also had the capacity to selectively infect subcutaneous or intracranial gliomas after intravenous inoculation. Intravenous or intracranial LuIII caused no adverse effects. Intracranial LuIII caused no infection of mature mouse neurons or glia in vivo but showed a modest infection of developing neurons.

  5. Gamma radiation exposure of accompanying persons due to Lu-177 patients

    NASA Astrophysics Data System (ADS)

    Kovan, Bilal; Demir, Bayram; Tuncman, Duygu; Capali, Veli; Turkmen, Cuneyt

    2015-07-01

    Neuroendocrine tumours (NET) are cancers usually observed and arisen in the stomach, intestine, pancreas and breathing system. Recently, radionuclide therapy applications with Lu-177 peptide compound are rapidly growing; especially effective clinical results are obtained in the treatment of well-differentiated and metastatic NET. In this treatment, Lu-177-DOTA, a beta emitter radioisotope in the radiopharmaceutical form, is given to the patient by intravenous way. Lu-177 has also gamma rays apart from beta rays. Gamma rays have 175 keV average energy and these gamma rays should be under the control in terms of radiation protection. In this study, we measured the exposure dose from the Lu-177 patient.

  6. Challenging the assumptions of Lu-Hf dating in spinel-peridotites

    NASA Astrophysics Data System (ADS)

    Byerly, B. L.; Lassiter, J. C.

    2013-12-01

    Lu-Hf 'pseudoisochrons' using peridotite-derived clinopyroxene separates are commonly used to constrain timing of melt depletion and lithosphere formation. However, cpx-based pseudoisochrons are only valid if 1) almost all Hf and Lu is hosted in the cpx, or 2) the system is below the mineral closure temperature. We tested these assumptions by examining Lu and Hf partitioning and Hf-isotope variations in cpx, opx, and bulk peridotite in xenoliths from the eastern Colorado Plateau and Rio Grande Rift. The samples primarily derive from Proterozoic SCLM, span a range of fertility (spinel Cr# range from 0.1-0.5), and have equilibration temperatures ranging from 950-1050°C, similar to temperatures reported for other xenoliths utilized in Lu-Hf isotope studies. Cpx have Hf and Lu concentrations ranging from 40-1000 ppb and 80-290 ppb, respectively. Opx have much lower Hf and Lu concentrations (5-60 ppb and 21-51 ppb). Concentrations of Lu, Hf, and other trace elements are well correlated between cpx and opx, indicating mineral equilibrium. DLucpx/opx and DHfcpx/opx range from 3.5-6.1 and 7.0-20, and are negatively correlated with cpx MgO content and other indices of peridotite fertility (e.g., spinel Cr#). Our results agree with (and extend the compositional range of) partition coefficients estimated following the formulation of [1]. The fraction of Lu and Hf hosted in opx increases in highly refractory samples. Although Lu/Hf in cpx is close to WR Lu/Hf in fertile samples, in refractory samples it is much lower. Hf isotopes in cpx are well correlated with cpx Lu/Hf (r2 = 0.998) and yield a pseudoisochron age of ~1.6 Ga (initial ɛHf of +30). Opx have systematically higher Lu/Hf than cpx, but in most samples have identical Hf isotopes. Some opx and WR have lower 176Hf/177Hf, similar to the host magma, likely reflecting melt contamination. The identical Hf isotopes in cpx and opx indicate that xenoliths evolved above the Lu-Hf closure temperature. Therefore, cpx (and opx

  7. Understanding the Interplay of Polar, Magnetic, and Electronic Order in Ferroic (LuFeO3)m /LuFe2O4 Superlattices

    NASA Astrophysics Data System (ADS)

    Rebola, Alejandro; Das, Hena; Fennie, Craig

    Multiferroics are not only important from a technological point of view but also because of the rich and complex physics that results from the interplay between spin, charge and structural distortions. Hexagonal LuFeO3 has recently been understood theoretical and experimentally, and shown to be an improper structural ferroelectric directly analogous to the hexagonal manganites. LuFe2O4 is structurally homologous to LuFeO3 -both are characterized by a FeO5 bipyramidal crystal field- but unlike the latter it exhibits a much larger magnetic moment and it is still a matter of debate whether it is ferroelectric. The double Fe-layer in LuFe2O4 is thought to be charge ordered and highly frustrated, resulting in possible polar, non-polar or anti-polar charge arrangements. Here we first investigate the relation between different charge and magnetic orders and structural distortions in bulk LuFe2O4 by DFT and Monte Carlo calculations. Then we concentrate on a system that combines both mechanisms -a structural improper ferroelectric and a charge frustrated polar structure- such as the (LuFeO3)m /LuFe2O4superlattices.

  8. Human erythrocyte antigens. Regulation of expression of a novel erythrocyte surface antigen by the inhibitor Lutheran In(Lu) gene.

    PubMed Central

    Telen, M J; Eisenbarth, G S; Haynes, B F

    1983-01-01

    Our study describes a novel human erythrocyte protein antigen, the expression of which is regulated by the rare Lutheran inhibitor In(Lu) gene. We have produced a monoclonal antibody (A3D8) that bound strongly to erythrocytes from subjects with Lutheran phenotypes Lu(a+b+), Lu(a+b-), and Lu(a-b+) but bound negligibly to erythrocytes from subjects with the dominant form of Lu(a-b-) phenotype, reflecting inheritance of the In(Lu) gene. Importantly, erythrocytes from an individual with the recessive form of Lu(a-b-) phenotype (i.e., absence of the In(Lu) gene and absence of genes encoding for Lutheran antigens) showed reactivity with A3D8 antibody comparable to that seen with Lu(a+) or Lu(b+) erythrocytes. A3D8 antigen activity was also found on all leukocytes and in serum and plasma; this activity also appeared to be regulated by the In(Lu) gene in serum, plasma, and on a subset of leukocytes. Thus, we have identified a human erythrocyte protein whose expression is modified by the In(Lu) gene. This knowledge that such an antigen exists on erythrocytes and in normal plasma should allow further studies into the molecular genetics of the In(Lu) gene and into the functional and structural significance of the A3D8 antigen. PMID:6863545

  9. Lu-177-Labeled Zirconia Particles for Radiation Synovectomy.

    PubMed

    Polyak, Andras; Nagy, Lívia Naszályi; Drotár, Eszter; Dabasi, Gabriella; Jóba, Róbert P; Pöstényi, Zita; Mikolajczak, Renata; Bóta, Attila; Balogh, Lajos

    2015-12-01

    The present article describes the preparation of β-emitter lutetium-177-labeled zirconia colloid and its preliminary physicochemical and biological evaluation of suitability for local radionuclide therapy. The new (177)Lu-labeled therapeutic radiopharmaceutical candidate was based on the synthesis mode of a previously described zirconia nanoparticle system. The size and shape of the developed radiopharmaceutical compound were observed through a scanning electron microscope and dynamic light scattering methods. The radiocolloid had a 1.7 μm mean diameter and showed high in vitro radiochemical and colloid size stability at room temperature and during the blood sera stability test. After the in vitro characterizations, the product was investigated in the course of the treatment of a spontaneously diseased dog veterinary patient's hock joint completed with single-photon emission computed tomography (SPECT) imaging follow-up measurements and a dual-isotope SPECT imaging tests with conventional (99m)Tc-methanediphosphonic acid bone scintigraphy. In the treated dog, no clinical side-effects or signs of histopathological changes of the joints were recorded during the treatment. SPECT follow-up studies clearly and conspicuously showed the localization of the (177)Lu-labeled colloid in the hock joint as well as detectable but negligible leakages of the radiocolloid in the nearest lymph node. On the basis of biological follow-up tests, the orthopedic team assumed that the (177)Lu-labeled zirconia colloid-based local radionuclide therapy resulted in a significant and long-term improvement in clinical signs of the patient without any remarkable side-effects.

  10. Lu-177-Labeled Zirconia Particles for Radiation Synovectomy.

    PubMed

    Polyak, Andras; Nagy, Lívia Naszályi; Drotár, Eszter; Dabasi, Gabriella; Jóba, Róbert P; Pöstényi, Zita; Mikolajczak, Renata; Bóta, Attila; Balogh, Lajos

    2015-12-01

    The present article describes the preparation of β-emitter lutetium-177-labeled zirconia colloid and its preliminary physicochemical and biological evaluation of suitability for local radionuclide therapy. The new (177)Lu-labeled therapeutic radiopharmaceutical candidate was based on the synthesis mode of a previously described zirconia nanoparticle system. The size and shape of the developed radiopharmaceutical compound were observed through a scanning electron microscope and dynamic light scattering methods. The radiocolloid had a 1.7 μm mean diameter and showed high in vitro radiochemical and colloid size stability at room temperature and during the blood sera stability test. After the in vitro characterizations, the product was investigated in the course of the treatment of a spontaneously diseased dog veterinary patient's hock joint completed with single-photon emission computed tomography (SPECT) imaging follow-up measurements and a dual-isotope SPECT imaging tests with conventional (99m)Tc-methanediphosphonic acid bone scintigraphy. In the treated dog, no clinical side-effects or signs of histopathological changes of the joints were recorded during the treatment. SPECT follow-up studies clearly and conspicuously showed the localization of the (177)Lu-labeled colloid in the hock joint as well as detectable but negligible leakages of the radiocolloid in the nearest lymph node. On the basis of biological follow-up tests, the orthopedic team assumed that the (177)Lu-labeled zirconia colloid-based local radionuclide therapy resulted in a significant and long-term improvement in clinical signs of the patient without any remarkable side-effects. PMID:26683134

  11. A Supernodal Approach to Incomplete LU Factorization with Partial Pivoting

    SciTech Connect

    Li, Xiaoye Sherry; Shao, Meiyue

    2009-06-25

    We present a new supernode-based incomplete LU factorization method to construct a preconditioner for solving sparse linear systems with iterative methods. The new algorithm is primarily based on the ILUTP approach by Saad, and we incorporate a number of techniques to improve the robustness and performance of the traditional ILUTP method. These include the new dropping strategies that accommodate the use of supernodal structures in the factored matrix. We present numerical experiments to demonstrate that our new method is competitive with the other ILU approaches and is well suited for today's high performance architectures.

  12. Chemistry and bifunctional chelating agents for binding (177)Lu.

    PubMed

    Parus, Józef L; Pawlak, Dariusz; Mikolajczak, Renata; Duatti, Adriano

    2015-01-01

    A short overview of fundamental chemistry of lutetium and of structural characteristics of lutetium coordination complexes, as relevant for understanding the properties of lutetium-177 radiopharmaceuticals, is presented. This includes basic concepts on lutetium electronic structure, lanthanide contraction, coordination geometries, behavior in aqueous solution and thermodynamic stability. An illustration of the structure and binding properties of the most important chelating agents for the Lu(3+) ion in aqueous solution is also reported with specific focus on coordination complexes formed with linear and macrocyclic polydentate amino-carboxylate donor ligands.

  13. A multigrid LU-SSOR scheme for approximate Newton iteration applied to the Euler equations

    NASA Technical Reports Server (NTRS)

    Yoon, Seokkwan; Jameson, Antony

    1986-01-01

    A new efficient relaxation scheme in conjunction with a multigrid method is developed for the Euler equations. The LU SSOR scheme is based on a central difference scheme and does not need flux splitting for Newton iteration. Application to transonic flow shows that the new method surpasses the performance of the LU implicit scheme.

  14. A block iterative LU solver for weakly coupled linear systems. [in fluid dynamics equations

    NASA Technical Reports Server (NTRS)

    Cooke, C. H.

    1977-01-01

    A hybrid technique, called the block iterative LU solver, is proposed for solving the linear equations resulting from a finite element numerical analysis of certain fluid dynamics problems where the equations are weakly coupled between distinct sets of variables. Either the block Jacobi iterative method or the block Gauss-Seidel iterative solver is combined with LU decomposition.

  15. Negative thermal expansion and anomalies of heat capacity of LuB50 at low temperatures

    DOE PAGES

    Novikov, V. V.; Zhemoedov, N. A.; Matovnikov, A. V.; Mitroshenkov, N. V.; Kuznetsov, S. V.; Bud'ko, S. L.

    2015-07-20

    Heat capacity and thermal expansion of LuB50 boride were experimentally studied in the 2–300 K temperature range. The data reveal an anomalous contribution to the heat capacity at low temperatures. The value of this contribution is proportional to the first degree of temperature. It was identified that this anomaly in heat capacity is caused by the effect of disorder in the LuB50 crystalline structure and it can be described in the soft atomic potential model (SAP). The parameters of the approximation were determined. The temperature dependence of LuB50 heat capacity in the whole temperature range was approximated by the summore » of SAP contribution, Debye and two Einstein components. The parameters of SAP contribution for LuB50 were compared to the corresponding values for LuB66, which was studied earlier. Negative thermal expansion at low temperatures was experimentally observed for LuB50. The analysis of the experimental temperature dependence for the Gruneisen parameter of LuB50 suggested that the low-frequency oscillations, described in SAP mode, are responsible for the negative thermal expansion. As a result, the glasslike character of the behavior of LuB50 thermal characteristics at low temperatures was confirmed.« less

  16. 176Lu-176Hf geochronology of garnet I: experimental determination of the diffusion kinetics of Lu3+ and Hf4+ in garnet, closure temperatures and geochronological implications

    NASA Astrophysics Data System (ADS)

    Bloch, Elias; Ganguly, Jibamitra; Hervig, Richard; Cheng, Weiji

    2015-02-01

    The 176Lu-176Hf and 147Sm-143Nd decay systems are routinely used to determine garnet (Grt)-whole-rock (WR) ages; however, the 176Lu-176Hf age of garnet is typically older than the 147Sm-143Nd age determined from the same aliquots. Here we present experimental data for Lu3+ and Hf4+ diffusion in garnet as functions of temperature, pressure and oxygen fugacity and show that the diffusivity of Hf4+ in almandine/spessartine garnet is significantly slower than that of Lu3+. The diffusive closure temperature ( T C) of Hf4+ is significantly higher than that of Nd3+, and although this property is partly responsible for the observed 176Lu-176Hf and 147Sm-143Nd Grt-WR age discrepancies, the difference between the T C-s of Lu3+ and Hf4+ could lead to apparent Grt-WR 176Lu-176Hf ages that are skewed from the age of Hf4+ closure in garnet. In addition, the slow diffusivity of Hf4+ indicates that the bulk of metamorphic garnets retain a substantial fraction of prograde radiogenic 176Hf throughout peak metamorphic conditions, a phenomenon that further complicates the interpretation of 176Lu-176Hf garnet ages and invalidates the use of analytical T C expressions. We argue that the diffusion of trivalent rare earth elements in garnet becomes much faster when their concentration level falls below a few hundred ppm, as in the experiments of Tirone et al. (Geochim Cosmochim Acta 69: 2385-2398, 2005), and further argue that this low-concentration mechanism is appropriate for modeling the susceptibility of 147Sm-143Nd garnet ages to diffusive resetting.

  17. Thermal neutron capture cross section for the K isomer {sup 177}Lu{sup m}

    SciTech Connect

    Belier, G.; Roig, O.; Daugas, J.-M.; Giarmana, O.; Meot, V.; Letourneau, A.; Marie, F.; Foucher, Y.; Aupiais, J.; Abt, D.; Jutier, Ch.; Le Petit, G.; Bettoni, C.; Gaudry, A.; Veyssiere, Ch.; Barat, E.; Dautremer, T.; Trama, J.-Ch.

    2006-01-15

    The thermal neutron radiative capture cross section for the K isomeric state in {sup 177}Lu has been measured for the first time. Several {sup 177}Lu{sup m} targets have been prepared and irradiated in various neutron fluxes at the Lauee Langevin Institute in Grenoble and at the CEA reactors OSIRIS and ORPHEE in Saclay. The method consists of measuring the {sup 178}Lu activity by {gamma}-ray spectroscopy. The values obtained in four different neutron spectra have been used to calculate the resonance integral of the radiative capture cross section for {sup 177}Lu{sup m}. In addition, an indirect method leads to the determination of the {sup 177}Lu{sup g} neutron radiative capture cross section.

  18. Green and red luminescence in co-precipitation synthesized Pr:LuAG nanophosphor

    NASA Astrophysics Data System (ADS)

    Kumar, S. Arun; Kumar, K. Ashok; Gunaseelan, M.; Asokan, K.; Senthilselvan, J.

    2016-05-01

    Pr:LuAG nanophosphor is an effective candidate in magnetic resonance imaging coupled positron emission tomography (MRI-PET) for medical imaging and scintillator applications. LuAG:Pr (0.05, 0.15 mol%) nanoscale ceramic powders were synthesized by co-precipitation method using urea as precipitant. Effect of antisite defect on structure and luminescence behavior was investigated. Pr:LuAG nanoceramic powders are found crystallized in cubic structure by high temperature calcination at 1400 °C and it shows antisite defect. HR-SEM analysis revealed spherically shaped Pr:LuAG nanoceramic particulate powders with ˜100 nm size. By the excitation at 450 nm, Pr:LuAG nanophosphor exhibit green to red luminescence in the wavelength range of 520 to 680 nm, which is originated from multiplet transition of Pr3+ ions.

  19. Stellar neutron capture cross sections of the Lu isotopes

    SciTech Connect

    Wisshak, K.; Voss, F.; Kaeppeler, F.; Kazakov, L.

    2006-01-15

    The neutron capture cross sections of {sup 175}Lu and {sup 176}Lu have been measured in the energy range 3-225 keV at the Karlsruhe 3.7 MV Van de Graaff accelerator. Neutrons were produced via the {sup 7}Li(p,n){sup 7}Be reaction by bombarding metallic Li targets with a pulsed proton beam, and capture events were registered with the Karlsruhe 4{pi} barium fluoride detector. The cross sections were determined relative to the gold standard using isotopically enriched as well as natural lutetium oxide samples. Overall uncertainties of {approx}1% could be achieved in the final cross section ratios to the gold standard, about a factor of 5 smaller than in previous works. Maxwellian averaged neutron capture cross sections were calculated for thermal energies between kT = 8 and 100 keV. These values are systematically larger by {approx}7% than those reported in recent evaluations. These results are of crucial importance for the assessment of the s-process branchings at A 175/176.

  20. Crystallization-Dependent Luminescence Properties of Ce:LuPO4.

    PubMed

    Sun, Congting; Li, Xingxing; Wang, Hao; Xue, Dongfeng

    2016-03-21

    The luminescence properties of Ce:LuPO4 depend on both the Ce(3+) center and the host lattice. In this article, we studied the dependence of the luminescence properties of Ce:LuPO4 on both the doping concentration of Ce(3+) and the size and morphology of the LuPO4 matrix at micro- and nanosize regimes. The crystalline behavior of Ce:LuPO4, including its size and shape, was investigated via precursor transformation crystallization. On the basis of this crystallization approach, Ce:LuPO4 hollow nanospheres, nanorods, and regular tetrahedrons were obtained. For micro- and nanostructured Ce:LuPO4, the surface-induced chemical bonding architecture can be effectively varied by controlling the size of the crystalline material and its geometry. Our experimental observations demonstrate that one-dimensional Ce:LuPO4 nanorods doped with 0.1 mol % Ce(3+) possess the best performance among the as-prepared samples. The significant anisotropy of Ce:LuPO4 nanorods can result in a larger specific surface area and enhanced luminescence properties. Moreover, the improved luminescence property of Ce:LuPO4 nanostructures can also be optimized by increasing the preferential anisotropic chemical bonding architecture to regulate the 5d level of Ce(3+). Our work also shows that the photoluminescence emission intensity of Ce:LuPO4 nanorods is increased as the surface area normal to their axial direction increases. From the standpoint of crystallization, the luminescence properties of Ce(3+) in nano- and microsize matrixes can be well-optimized by controlling the crystalline behavior of the host lattice under proper synthesis conditions. PMID:26863291

  1. Crystallization-Dependent Luminescence Properties of Ce:LuPO4.

    PubMed

    Sun, Congting; Li, Xingxing; Wang, Hao; Xue, Dongfeng

    2016-03-21

    The luminescence properties of Ce:LuPO4 depend on both the Ce(3+) center and the host lattice. In this article, we studied the dependence of the luminescence properties of Ce:LuPO4 on both the doping concentration of Ce(3+) and the size and morphology of the LuPO4 matrix at micro- and nanosize regimes. The crystalline behavior of Ce:LuPO4, including its size and shape, was investigated via precursor transformation crystallization. On the basis of this crystallization approach, Ce:LuPO4 hollow nanospheres, nanorods, and regular tetrahedrons were obtained. For micro- and nanostructured Ce:LuPO4, the surface-induced chemical bonding architecture can be effectively varied by controlling the size of the crystalline material and its geometry. Our experimental observations demonstrate that one-dimensional Ce:LuPO4 nanorods doped with 0.1 mol % Ce(3+) possess the best performance among the as-prepared samples. The significant anisotropy of Ce:LuPO4 nanorods can result in a larger specific surface area and enhanced luminescence properties. Moreover, the improved luminescence property of Ce:LuPO4 nanostructures can also be optimized by increasing the preferential anisotropic chemical bonding architecture to regulate the 5d level of Ce(3+). Our work also shows that the photoluminescence emission intensity of Ce:LuPO4 nanorods is increased as the surface area normal to their axial direction increases. From the standpoint of crystallization, the luminescence properties of Ce(3+) in nano- and microsize matrixes can be well-optimized by controlling the crystalline behavior of the host lattice under proper synthesis conditions.

  2. Quasi-spherical LuBO{sub 3} nanoparticles: Synthesis, formation, and luminescence properties

    SciTech Connect

    Gao, Yu; Yang, Feng; Han, Wenchi; Fang, Qinghong; Xu, Zhenhe

    2014-03-01

    Graphical abstract: Quasi-spherical LuBO3 nanoparticles have been prepared via a facile hydrothermal route. The possible growth mechanism and the luminescent properties of the as-prepared microcrystals have been discussed. - Highlights: • LuBO{sub 3} nanoparticles were prepared by a facile hydrothermal route. • The Eu{sup 3+} and Tb{sup 3+}-doped LuBO{sub 3} products show strong red and green emissions. • This method may be more widely applicable in the design of other rare-earth compounds. - Abstract: Quasi-spherical LuBO{sub 3} nanoparticles have been successfully synthesized by a designed hydrothermal conversion method. The Lu(OH)CO{sub 3} nanoparticles were first prepared by a simple homogeneous precipitation method. Subsequently, LuBO{sub 3} nanoparticles were synthesized at the expense of the Lu(OH)CO{sub 3} nanoparticles during a hydrothermal conversion process. The conversion process from the Lu(OH)CO{sub 3} precursor to LuBO{sub 3} nanoparticles was investigated by time-dependent experiments. Moreover, the as-obtained Eu{sup 3+} and Tb{sup 3+}-doped LuBO{sub 3} products show strong characteristic red and green emissions under ultraviolet excitation and low-voltage electron beam excitation, respectively. This work sheds some light on the knowledge of conversion of different kind of lutetium compounds, and the luminescent properties have potential applications in fluorescent lamps and field emission displays. More importantly, this simple method is expected to allow the large-scale production of other complex rare-earth compounds with controllable morphologies and sizes, and exploration of the morphology and photoluminescence properties.

  3. Lu-Hf and Sm-Nd evolution in lunar mare basalts

    NASA Technical Reports Server (NTRS)

    Unruh, D. M.; Tatsumoto, M.; Stille, P.; Patchett, P. J.

    1984-01-01

    Existing cumulate remelting models for mare basalt genesis are evaluated in light of Lu-Hf, Rb-Sr, Sm-Nd data and overall REE characteristics in order to determine the simplest model that can account for these data. A data base for comparing Lu-Hf evolution in the lunar mantle as inferred from Lu-Hf analyses of oceanic basalts is presented along with a preliminary comparison of Lu-Hf and Sm-Nd evolution betwee mare basalts and terrestrial oceanic basalts. It is found that Lu/Hf characteristics of mare basalts cannot be explained in terms of modal melting of cumulate sources formed from a magma ocean with chondritic Lu/Hf. The data are consistent with a model in which the cumulate sources formed from a light REE + HF-enriched magma ocean. Nonmodal melting of ilmenite in the sources is also required. The Lu-Hf data suggest that even the high-Ti basalt sources contained no more than about 3 percent ilmenite.

  4. Influence of Eu(3+) doping content on antioxidant properties of Lu2O3 sol-gel derived nanoparticles.

    PubMed

    Olvera Salazar, Arturo; García Hernández, Margarita; López Camacho, Perla Yolanda; López Marure, Arturo; Reyes de la Torre, Adriana Isabel; Morales Ramírez, Ángel de Jesús; Hernández Santiago, Felipe; Aguilera Vázquez, Luciano

    2016-12-01

    This paper presents the synthesis of pure and europium-doped lutetium oxide (Lu2O3) powders prepared by sol-gel method. The influence of europium ion concentration into Lu2O3 nanocrystallites was investigated for first time in an in vitro system using a modified ABTS radical cation decolorization assay to determine the antioxidant activity. The crystalline structure of Lu2O3 and Eu:Lu2O3 powders was elucidated by XRD obtaining cubic phase in all system without secondary products in accordance with FT-IR results. By TEM and Scherrer equation, it was determined that Lu2O3 and Eu:Lu2O3 powders presented nearly spherical particle morphology with crystallites sizes in the range of 8 to 13nm. The antioxidant assays results revealed that europium ion enhance Lu2O3 powders antioxidant properties, showing that 12.5mol% of europium is sufficient to reach its maximum capacity.

  5. Spectral ordering techniques for incomplete LU preconditoners for CG methods

    NASA Technical Reports Server (NTRS)

    Clift, Simon S.; Simon, Horst D.; Tang, Wei-Pai

    1995-01-01

    The effectiveness of an incomplete LU (ILU) factorization as a preconditioner for the conjugate gradient method can be highly dependent on the ordering of the matrix rows during its creation. Detailed justification for two heuristics commonly used in matrix ordering for anisotropic problems is given. The bandwidth reduction and weak connection following heuristics are implemented through an ordering method based on eigenvector computations. This spectral ordering is shown to be a good representation of the heuristics. Analysis and test cases in two and three dimensional diffusion problems demonstrate when ordering is important, and when an ILU decomposition will be ordering insensitive. The applicability of the heuristics is thus evaluated and placed on a more rigorous footing.

  6. Quadrupole moments of wobbling excitations in 163Lu

    SciTech Connect

    Gorgen, A.; Clark, R.M.; Cromaz, M.; Fallon, P.; Hagemann, G.B.; Hubel, H.; Lee, I.Y.; Macchiavelli, A.O.; Sletten, G.; Ward, D.; Bengtsson, R.

    2004-01-01

    Lifetimes of states in the triaxial strongly deformed bands of {sup 163}Lu have been measured in a Gammasphere experiment using the Doppler-shift attenuation method. The bands are interpreted as wobbling-phonon excitations from the characteristic electromagnetic properties of the transitions connecting the bands. Quadrupole moments were extracted for the 0-phonon yrast band and, for the first time, for the 1-phonon wobbling band. The very similar results found for both bands suggest a similar intrinsic structure confirming the wobbling interpretation. While the in-band quadrupole moments for the bands show a decreasing trend towards higher spin, the strength of the inter-band transitions remains constant. Both features can be understood by a small increase in triaxiality towards higher spin. Such a change in triaxiality is also found in cranking calculations, to which the experimental results are compared.

  7. Turbulence profiles of the future E-ELT with LuSci (Lunar Scintillometer)

    NASA Astrophysics Data System (ADS)

    Char, F.; Lombardi, G.; Sarazin, M.; González, C.; Navarrete, J.

    The Lunar Scintillometer (LuSci) is an instrument used to analyze the Surface Layer in all the candidate sites for the E-ELT. Currently is used in the monitoring of the chosen site, Cerro Armazones. LuSci has proved to be a portable and reliable tool, in the aim to estimate the distribution of the turbulence in the Ground Layer, when used in combination with several other turbulence profilers, such as MASS, DIMM and SLODAR. In this way, LuSci has provided valuable data in order to characterize the Ground Layer and the relevant portion of turbulence for the future largest optical/infrared observatory in the world.

  8. Lu-hf total-rock isochron for the eucrite meteorites

    USGS Publications Warehouse

    Patchett, P.J.; Tatsumoto, M.

    1980-01-01

    The isotope 176Lu (2.6% of natural lutetium) decays by ??- to 176Hf, with a long half life. We present here the first Lu-Hf isochron. The eucrite meteorites, a suite of planetary igneous rocks of known age, 4,550 Myr, define a 10-point total-rock isochron with a slope of 0.0934 ?? 40, leading to a value of 3.53 ?? 0.14 ??1010yr for the ??--decay half life of 176Lu. The isochron intercept of 0.27973 ?? 12 gives the initial 176Hf/177Hf for the inner Solar System at the time of accretion. ?? 1980 Nature Publishing Group.

  9. Research on the change of chemical composition in productive process of Re Du Ning injection by HPLC/Q-TOF MS.

    PubMed

    Zhang, Shan; Li, Yan-Jing; Zhang, Chun-Xiao; Huang, Wen-Zhe; Ding, Gang; Wang, Zhen-Zhong; Bi, Yu-An; Xiao, Wei

    2016-02-01

    A high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) was developed for the analysis of chemical composition change in the production process of Re Du Ning injection, a Chinese medicine preparation with a combination of Lonicera japonica Thunb., Gardenia jasminoides Ellis and Artemisia annua L. A total of 90 compounds from raw materials-intermediates-Re Du Ning injection were detected; among them, 55 compounds were identified or tentatively characterized, and the characteristic ions of different types of compounds were described. Based on these studies, the different types of compounds in the various process routes were analyzed. A total of 28 compounds, including seven iridoid glycosides and six monoterpenes from G. jasminoides Ellis, five iridoid glycosides, nine phenolic acids and one unknown compound from L. japonica Thunb., were transferred to Re Du Ning injection, and two unknown compounds were generated in the production process of Re Du Ning injection. The results indicated that the Chinese Medicine Pharmaceutical process control is very important. This method could provide some reference for other Chinese medicine preparations.

  10. Research on the change of chemical composition in productive process of Re Du Ning injection by HPLC/Q-TOF MS.

    PubMed

    Zhang, Shan; Li, Yan-Jing; Zhang, Chun-Xiao; Huang, Wen-Zhe; Ding, Gang; Wang, Zhen-Zhong; Bi, Yu-An; Xiao, Wei

    2016-02-01

    A high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) was developed for the analysis of chemical composition change in the production process of Re Du Ning injection, a Chinese medicine preparation with a combination of Lonicera japonica Thunb., Gardenia jasminoides Ellis and Artemisia annua L. A total of 90 compounds from raw materials-intermediates-Re Du Ning injection were detected; among them, 55 compounds were identified or tentatively characterized, and the characteristic ions of different types of compounds were described. Based on these studies, the different types of compounds in the various process routes were analyzed. A total of 28 compounds, including seven iridoid glycosides and six monoterpenes from G. jasminoides Ellis, five iridoid glycosides, nine phenolic acids and one unknown compound from L. japonica Thunb., were transferred to Re Du Ning injection, and two unknown compounds were generated in the production process of Re Du Ning injection. The results indicated that the Chinese Medicine Pharmaceutical process control is very important. This method could provide some reference for other Chinese medicine preparations. PMID:26058547

  11. Diauxic growth and microstructure of grain interfaces in thermal bonding Yb:LuAG/LuAG ceramic

    NASA Astrophysics Data System (ADS)

    Zhou, Chunlin; Jiang, Benxue; Fan, Jintai; Mao, Xiaojian; Zhang, Long; Fang, Yongzheng

    2015-07-01

    Transparent composite Lutetium aluminum garnet (LuAG) ceramics were successfully synthesized by thermal diffusion bonding method. Three isothermal holding temperature of 1450°C, 1600°C, 1780°C for 10h under vacuum were used to study the changes of bonding interface morphology, Optical microscope, SEM and laser interferometer (GPI-XP,zygo) study show that diauxic growth of grain interface appears when the thermal bonding holding temperature increased. The sintering mechanism of diauxic growth of grain interface during the thermal diffusion bonding was also discussed using diffusion theory. The diauxic growth of grain interface provides us the possibility to get high quality composite laser ceramics as we designed.

  12. One-pot β-cyclodextrin-assisted extraction of active ingredients from Xue-Zhi-Ning basing its encapsulated ability.

    PubMed

    Zhang, Hui-Jie; Liu, Ya-Nan; Wang, Meng; Wang, Yue-Fei; Deng, Yan-Ru; Cui, Ming-Lei; Ren, Xiao-Liang; Qi, Ai-Di

    2015-11-01

    Xue-Zhi-Ning (XZN) is a traditional Chinese medicine formula, containing active ingredients with poor solubility in water, which has been demonstrated to be helpful for patients with hyperlipidemia. One-pot β-cyclodextrin (β-CD)-assisted extraction of active ingredients from XZN has been carried out to develop an efficient and eco-friendly extraction process. Five active compounds--rubrofusarin gentiobioside, 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside, emodin, nuciferine and quercetin--were identified by UPLC/DAD/MS and used as indexes to evaluate the process optimized by an orthogonal test. The results showed that addition of β-CD significantly enhanced the extraction ratios of all five components. The enhancement of extraction ratios was positively correlated with the apparent formation constants between β-CD and the compounds. The study also showed that the stabilities and dissolution rates of the active ingredients were improved in the presence of β-CD. This one-pot β-cyclodextrin-assisted extraction has the potential to be applied in pharmaceutical preparations directly. PMID:26256368

  13. Fabrication and characterization of Eu3+-doped Lu2O3 scintillation ceramics

    NASA Astrophysics Data System (ADS)

    Kopylov, Yu. L.; Kravchenko, V. B.; Dulina, N. A.; Lopin, А. V.; Parkhomenko, S. V.; Tolmachev, A. V.; Yavetskiy, R. P.; Zelenskaya, O. V.

    2013-02-01

    Density, morphology, optical transmittance and luminescence of undoped and europium-doped Lu2O3 ceramics have been studied. It has been revealed that europium ions in concentration of 5 at.% act as a solid-state sintering aids in Lu2O3 ceramics promoting its densification. Lu2O3:Eu3+ optical ceramics with relative density of 98 ± 2%, with an average grain size of 50 μm and in-line transmittance of 41% in the visible wavelength range has been produced by vacuum sintering at Т = 1850 °С. The scintillation characteristics of Lu2O3:Eu3+ ceramics under excitation with α-particles (238Рu source, E = 5.46 МeV) have been determined for the first time (S = 500 ± 50 photons/МeV, R = 26.5%).

  14. Intrinsic magnetic properties of hexagonal LuFeO{sub 3} and the effects of nonstoichiometry

    SciTech Connect

    Moyer, Jarrett A. E-mail: schlom@cornell.edu; Schiffer, Peter; Misra, Rajiv; Mundy, Julia A.; Brooks, Charles M.; Heron, John T.; Muller, David A.; Schlom, Darrell G. E-mail: schlom@cornell.edu

    2014-01-01

    We used oxide molecular-beam epitaxy in a composition-spread geometry to deposit hexagonal LuFeO{sub 3} (h-LuFeO{sub 3}) thin films with a monotonic variation in the Lu/Fe cation ratio, creating a mosaic of samples that ranged from iron rich to lutetium rich. We characterized the effects of composition variation with x-ray diffraction, atomic force microscopy, scanning transmission electron microscopy, and superconducting quantum interference device magnetometry. After identifying growth conditions leading to stoichiometric film growth, an additional sample was grown with a rotating sample stage. From this stoichiometric sample, we determined stoichiometric h-LuFeO{sub 3} to have a T{sub N} = 147 K and M{sub s} = 0.018 μ{sub B}/Fe.

  15. High-spin states in doubly odd {sup 162,164}Lu

    SciTech Connect

    Cardona, M.A.; Hojman, D.; Debray, M.E.; Kreiner, A.J.; Somacal, H.; Cardona, M.A.; Hojman, D.; Debray, M.E.; Kreiner, A.J.; Somacal, H.; Davidson, J.; Davidson, M.; Davidson, J.; Hojman, D.; Kreiner, A.J.; Davidson, M.; Napoli, D.R.; Burch, R.; De Acuna, D.; Rico, J.; Bazzacco, D.; Lenzi, S.M.; Rossi Alvarez, C.; Blasi, N.; Lo Bianco, G.

    1997-08-01

    High-spin states in {sup 162}Lu and {sup 164}Lu have been studied by means of in-beam {gamma}-ray spectroscopy techniques using the multidetector array GASP. The excited states have been populated through the {sup 139}La({sup 28}Si,5n){sup 162}Lu and {sup 139}La[{sup 29(30)}Si,4(5)n]{sup 164}Lu reactions. Level schemes were constructed for both nuclei. Configurations for the rotational bands have been discussed. Alignments, band crossing frequencies, and B(M1)/B(E2) ratios have been analyzed in the framework of the cranking model. The systematic evolution of the signature inversion in the {pi}h{sub 11/2}{circle_times}{nu}i{sub 13/2} structure is reviewed. {copyright} {ital 1997} {ital The American Physical Society}

  16. Recent Terrestrial Disturbance of the 176Lu-176Hf Systematics in Meteorites

    NASA Astrophysics Data System (ADS)

    Bast, R.; Scherer, E. E.; Sprung, P.; Mezger, K.; Bischoff, A.

    2016-08-01

    The Lu-Hf isotope systematics of many achondrites exhibit excessive scatter above a solar system isochron that cannot be explained by early solar system processes but by recent terrestrial weathering or contamination.

  17. Practical aspects of peptide receptor radionuclide therapy with [177Lu][DOTA0, Tyr3]octreotate.

    PubMed

    Bakker, W H; Breeman, W A P; Kwekkeboom, D J; De Jong, L C; Krenning, E P

    2006-12-01

    Lutetium-177 is increasingly used in patients for receptor-targeted radionuclide therapy with peptides such as [DOTA0,Tyr3]octreotate. In our therapy facility, we are performing yearly 400 treatments with each 7.4 GBq [177Lu][DOTA0,Tyr3]octreotate. Finger dosimetry data during radiolabeling reveal higher doses on the right hands of right-handed workers with the highest equivalent dose for the middle finger (53+/-12 microSv/GBq). Extrapolating dosimetry data, assuming 400 doses of 7.4 GBq per year performed by 4 workers, result in a mean equivalent dose of 23+/-11 mSv and 14+/-6 mSv for finger top and ring dose, respectively. Preparation of 400 doses will result in an effective dose of 0.5-1.5 mSv per year for these 4 workers. The extra radiation dose for workers during the radiolabeling of these doses thus remains below 10% of the legal annual limits, which is in accordance with the ALARA optimization principle. Based on measurements of the maximal radiation level at 1 m distance (7.5+/-3.6 microSv/h), patients treated with 7.4 GBq [177Lu][DOTA0,Tyr3]octreotate can already leave the therapy facility the next day. As radioactive waste streams are based on the half-lives of the used radionuclides, 177Lu-waste (t1/2=6.7 d) was initially collected along with the 131I-waste (t1/2=8 d). According to both manufacturers' specifications, 177Lu contains less than 0.4 kBq 177mLu/MBq 177Lu (at the end of neutron irradiation), when produced by the [176Lu n, gamma 177Lu] reaction via thermal neutron bombardment of enriched lutetium oxide. Unfortunately, because of the huge amounts of 177Lu used, contaminating 177mLu turned out to prevent the quick discharge of this waste, for some containers even after some years of storage. Therefore, a technique for calibrating 177mLu was developed, simultaneously confirming the manufacturer's specifications on the presence of 177mLu in 177Lu. Subsequently a reliable technique was developed to measure 177mLu in waste containers using a beta

  18. Magnetic phase transitions in Pr(1-x)Lu(x)Mn(2)Ge(2) compounds.

    PubMed

    Wang, J L; Campbell, S J; Studer, A J; Avdeev, M; Zeng, R; Dou, S X

    2009-03-25

    The effects of replacing Pr by Lu on the magnetic behaviour and structures of Pr(1-x)Lu(x)Mn(2)Ge(2) (x = 0.2,x = 0.4) have been investigated using x-ray diffraction, Mössbauer spectroscopy, magnetization and neutron diffraction measurements. The substitution of Lu for Pr leads to a decrease in the lattice constants a, c and the unit cell volume V at room temperature with this contraction of the unit cell resulting in modifications of the Pr(1-x)Lu(x)Mn(2)Ge(2) magnetic structures. Four and five magnetic phase transitions-linked primarily with temperature driven changes in the intralayer Mn-Mn separation distances-have been detected within the temperature range 4.5-550 K for Pr(0.8)Lu(0.2)Mn(2)Ge(2) and Pr(0.6)Lu(0.4)Mn(2)Ge(2), respectively, with re-entrant ferromagnetism being detected around T(C)(Pr)∼31 K for Pr(0.6)Lu(0.4)Mn(2)Ge(2). It was found that T(C)(inter) and T(C)(Pr) increase with increasing applied field while T(N)(inter) decreases for Pr(0.6)Lu(0.4)Mn(2)Ge(2), indicating that the canted antiferromagnetic AFmc region contracts with increasing field. The Debye temperatures for Pr(1-x)Lu(x)Mn(2)Ge(2) with x = 0.2 and 0.4 were evaluated as θ(D) = 320 ± 40 K and θ(D) = 400 ± 20 K respectively from the temperature dependence of the average isomer shift. The magnetic structures of both compounds have been determined by means of neutron diffraction measurements over the temperature range 3-300 K with formation of the Fmi magnetic state below T(c/c) = 192 K for Pr(0.8)Lu(0.2)Mn(2)Ge(2) and the occurrence of re-entrant ferromagnetism below T(C)(Pr) = 31 K for Pr(0.6)Lu(0.4)Mn(2)Ge(2) being confirmed. PMID:21817459

  19. Langston University - High Energy Physics (LU-HEP)

    SciTech Connect

    Snow, Dr., Joel

    2012-08-13

    This final report is presented by Langston University (LU) for the project entitled "Langston University High Energy Physics" (LUHEP) under the direction of principal investigator (PI) and project director Professor Joel Snow. The project encompassed high energy physics research performed at hadron colliders. The PI is a collaborator on the DZero experiment at Fermi National Accelerator Laboratory in Batavia, IL, USA and the ATLAS experiment at CERN in Geneva, Switzerland and was during the entire project period from April 1, 1999 until May 14, 2012. Both experiments seek to understand the fundamental constituents of the physical universe and the forces that govern their interactions. In 1999 as member of the Online Systems group for Run 2 the PI developed a cross-platform Python-based, Graphical User Interface (GUI) application for monitoring and control of EPICS based devices for control room use. This served as a model for other developers to enhance and build on for further monitoring and control tasks written in Python. Subsequently the PI created and developed a cross-platform C++ GUI utilizing a networked client-server paradigm and based on ROOT, the object oriented analysis framework from CERN. The GUI served as a user interface to the Examine tasks running in the D\\O\\ control room which monitored the status and integrity of data taking for Run 2. The PI developed the histogram server/control interface to the GUI client for the EXAMINE processes. The histogram server was built from the ROOT framework and was integrated into the D\\O\\ framework used for online monitoring programs and offline analysis. The PI developed the first implementation of displaying histograms dynamically generated by ROOT in a Web Browser. The PI's work resulted in several talks and papers at international conferences and workshops. The PI established computing software infrastructure at LU and U. Oklahoma (OU) to do analysis of DZero production data and produce simulation data

  20. Isomeric ratio measurements for the radiative neutron capture 176Lu(n,γ) at DANCE

    NASA Astrophysics Data System (ADS)

    Denis-Petit, D.; Roig, O.; Méot, V.; Jandel, M.; Vieira, D. J.; Bond, E. M.; Bredeweg, T. A.; Couture, A. J.; Haight, R. C.; Keksis, A. L.; Rundberg, R. S.; Ullmann, J. L.

    2016-03-01

    The isomeric ratio for the neutron capture reaction 176Lu(n,γ) on the Jπ= 5/2-, 761.7 keV, T1/2=32.8 ns level of 177mLu, has been determined in the neutron energy range 8.5 eV-100 keV for the first time using the DANCE array at the Los Alamos National Laboratory.

  1. Multimodal Somatostatin Receptor Theranostics Using [64Cu]Cu-/[177Lu]Lu-DOTA-(Tyr3)octreotate and AN-238 in a Mouse Pheochromocytoma Model

    PubMed Central

    Ullrich, Martin; Bergmann, Ralf; Peitzsch, Mirko; Zenker, Erik F.; Cartellieri, Marc; Bachmann, Michael; Ehrhart-Bornstein, Monika; Block, Norman L.; Schally, Andrew V.; Eisenhofer, Graeme; Bornstein, Stefan R.; Pietzsch, Jens; Ziegler, Christian G.

    2016-01-01

    Pheochromocytomas and extra-adrenal paragangliomas (PHEO/PGLs) are rare catecholamine-producing chromaffin cell tumors. For metastatic disease, no effective therapy is available. Overexpression of somatostatin type 2 receptors (SSTR2) in PHEO/PGLs promotes interest in applying therapies using somatostatin analogs linked to radionuclides and/or cytotoxic compounds, such as [177Lu]Lu-DOTA-(Tyr3)octreotate (DOTATATE) and AN-238. Systematic evaluation of such therapies for the treatment of PHEO/PGLs requires sophisticated animal models. In this study, the mouse pheochromocytoma (MPC)-mCherry allograft model showed high tumor densities of murine SSTR2 (mSSTR2) and high tumor uptake of [64Cu]Cu-DOTATATE. Using tumor sections, we assessed mSSTR2-specific binding of DOTATATE, AN-238, and somatostatin-14. Therapeutic studies showed substantial reduction of tumor growth and tumor-related renal monoamine excretion in tumor-bearing mice after treatment with [177Lu]Lu-DOTATATE compared to AN-238 and doxorubicin. Analyses did not show agonist-dependent receptor downregulation after single mSSTR2-targeting therapies. This study demonstrates that the MPC-mCherry model is a uniquely powerful tool for the preclinical evaluation of SSTR2-targeting theranostic applications in vivo. Our findings highlight the therapeutic potential of somatostatin analogs, especially of [177Lu]Lu-DOTATATE, for the treatment of metastatic PHEO/PGLs. Repeated treatment cycles, fractionated combinations of SSTR2-targeting radionuclide and cytotoxic therapies, and other adjuvant compounds addressing additional mechanisms may further enhance therapeutic outcome. PMID:27022413

  2. Multimodal Somatostatin Receptor Theranostics Using [(64)Cu]Cu-/[(177)Lu]Lu-DOTA-(Tyr(3))octreotate and AN-238 in a Mouse Pheochromocytoma Model.

    PubMed

    Ullrich, Martin; Bergmann, Ralf; Peitzsch, Mirko; Zenker, Erik F; Cartellieri, Marc; Bachmann, Michael; Ehrhart-Bornstein, Monika; Block, Norman L; Schally, Andrew V; Eisenhofer, Graeme; Bornstein, Stefan R; Pietzsch, Jens; Ziegler, Christian G

    2016-01-01

    Pheochromocytomas and extra-adrenal paragangliomas (PHEO/PGLs) are rare catecholamine-producing chromaffin cell tumors. For metastatic disease, no effective therapy is available. Overexpression of somatostatin type 2 receptors (SSTR2) in PHEO/PGLs promotes interest in applying therapies using somatostatin analogs linked to radionuclides and/or cytotoxic compounds, such as [(177)Lu]Lu-DOTA-(Tyr(3))octreotate (DOTATATE) and AN-238. Systematic evaluation of such therapies for the treatment of PHEO/PGLs requires sophisticated animal models. In this study, the mouse pheochromocytoma (MPC)-mCherry allograft model showed high tumor densities of murine SSTR2 (mSSTR2) and high tumor uptake of [(64)Cu]Cu-DOTATATE. Using tumor sections, we assessed mSSTR2-specific binding of DOTATATE, AN-238, and somatostatin-14. Therapeutic studies showed substantial reduction of tumor growth and tumor-related renal monoamine excretion in tumor-bearing mice after treatment with [(177)Lu]Lu-DOTATATE compared to AN-238 and doxorubicin. Analyses did not show agonist-dependent receptor downregulation after single mSSTR2-targeting therapies. This study demonstrates that the MPC-mCherry model is a uniquely powerful tool for the preclinical evaluation of SSTR2-targeting theranostic applications in vivo. Our findings highlight the therapeutic potential of somatostatin analogs, especially of [(177)Lu]Lu-DOTATATE, for the treatment of metastatic PHEO/PGLs. Repeated treatment cycles, fractionated combinations of SSTR2-targeting radionuclide and cytotoxic therapies, and other adjuvant compounds addressing additional mechanisms may further enhance therapeutic outcome. PMID:27022413

  3. Tumoral fibrosis effect on the radiation absorbed dose of (177)Lu-Tyr(3)-octreotate and (177)Lu-Tyr(3)-octreotate conjugated to gold nanoparticles.

    PubMed

    Azorín-Vega, E P; Zambrano-Ramírez, O D; Rojas-Calderón, E L; Ocampo-García, B E; Ferro-Flores, G

    2015-06-01

    The aim of this work was to evaluate the tumoral fibrosis effect on the radiation absorbed dose of the radiopharmaceuticals (177)Lu-Tyr(3)-octreotate (monomeric) and (177)Lu-Tyr(3)-octreotate-gold nanoparticles (multimeric) using an experimental HeLa cells tumoral model and the Monte Carlo PENELOPE code. Experimental and computer micro-environment models with or without fibrosis were constructed. Results showed that fibrosis increases up to 33% the tumor radiation absorbed dose, although the major effect on the dose was produced by the type of radiopharmaceutical (112Gy-multimeric vs. 43Gy-monomeric).

  4. Tumoral fibrosis effect on the radiation absorbed dose of (177)Lu-Tyr(3)-octreotate and (177)Lu-Tyr(3)-octreotate conjugated to gold nanoparticles.

    PubMed

    Azorín-Vega, E P; Zambrano-Ramírez, O D; Rojas-Calderón, E L; Ocampo-García, B E; Ferro-Flores, G

    2015-06-01

    The aim of this work was to evaluate the tumoral fibrosis effect on the radiation absorbed dose of the radiopharmaceuticals (177)Lu-Tyr(3)-octreotate (monomeric) and (177)Lu-Tyr(3)-octreotate-gold nanoparticles (multimeric) using an experimental HeLa cells tumoral model and the Monte Carlo PENELOPE code. Experimental and computer micro-environment models with or without fibrosis were constructed. Results showed that fibrosis increases up to 33% the tumor radiation absorbed dose, although the major effect on the dose was produced by the type of radiopharmaceutical (112Gy-multimeric vs. 43Gy-monomeric). PMID:25305748

  5. Resistive switching behavior in Lu2O3 thin film for advanced flexible memory applications

    PubMed Central

    2014-01-01

    In this article, the resistive switching (RS) behaviors in Lu2O3 thin film for advanced flexible nonvolatile memory applications are investigated. Amorphous Lu2O3 thin films with a thickness of 20 nm were deposited at room temperature by radio-frequency magnetron sputtering on flexible polyethylene terephthalate substrate. The structural and morphological changes of the Lu2O3 thin film were characterized by x-ray diffraction, atomic force microscopy, and x-ray photoelectron spectroscopy analyses. The Ru/Lu2O3/ITO flexible memory device shows promising RS behavior with low-voltage operation and small distribution of switching parameters. The dominant switching current conduction mechanism in the Lu2O3 thin film was determined as bulk-controlled space-charge-limited-current with activation energy of traps of 0.33 eV. The oxygen vacancies assisted filament conduction model was described for RS behavior in Lu2O3 thin film. The memory reliability characteristics of switching endurance, data retention, good flexibility, and mechanical endurance show promising applications in future advanced memory. PMID:24387704

  6. Correlation between magnon and magnetic symmetries of hexagonal RMnO3 (R = Er, Ho, Lu)

    NASA Astrophysics Data System (ADS)

    Nguyen, Thi Minh Hien; Nguyen, Thi Huyen; Chen, Xiang-Bai; Park, Yeonju; Jung, Young Mee; Lee, D.; Noh, T. W.; Cheong, Sang-Wook; Yang, In-Sang

    2016-11-01

    The correlation between the magnon scattering and the magnetic symmetries of hexagonal RMnO3 (R = Er, Ho) thin films and LuMnO3 single crystal was studied through the 2D Correlation Spectroscopy (2D COS) and Perturbation-Correlation Moving Window 2D (PCMW2D) Correlation Spectroscopy which were performed on the temperature-dependent Raman spectra of RMnO3 (R = Er, Ho, Lu). From the Raman spectra, we observed much stronger intensity and more asymmetrical magnon peak in LuMnO3 single crystal than in ErMnO3 and HoMnO3 thin films. While the ratio between magnon and phonon's linewidth of LuMnO3 and HoMnO3 display an anomalous behavior, that ratio of ErMnO3 is almost stable. The result from PCMW2D also supports these results. In addition, our 2D COS analysis showed that there are more overlap peaks in broad four-spin flipping magnon peak in LuMnO3 than that in ErMnO3 and HoMnO3. The differences of hexagonal RMnO3 (R = Er, Ho, Lu) in magnon scattering are very similar to the actual differences of the magnetic symmetries of these compounds. Therefore, we suggest that the magnon scattering of hexagonal RMnO3 is strongly correlated with the magnetic symmetries of these materials.

  7. Overview of Development and Formulation of ¹⁷⁷Lu-DOTA-TATE for PRRT.

    PubMed

    Breeman, Wouter A P; Chan, Ho Sze; de Zanger, Rory M S; Konijnenberg, Mark K; de Blois, Erik

    2016-01-01

    Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin analogs has become an established procedure for the treatment of patients suffering from inoperable neuroendocrine cancers over-expressing somatostatin receptors. Success of PRRT depends on the availability of the radiolabeled peptide with adequately high specific activity, so that required therapeutic efficacy can be achieved without saturating the limited number of receptors available on the target lesions. Specific activity of the radionuclide and the radiolabeled somatostatin analog are therefore an important parameters. Although these analogs have been investigated and improved, and successfully applied for PRRT for more than 15 years, there are still many possibilities for further improvements that fully exploit PRRT with 177Lu-DOTA-TATE. The here summarized data presented herein on increased knowledge of the components of 177Lu-DOTA-TATE (especially the purity of 177Lu and specific activity of 177Lu) and the reaction kinetics during labeling 177Lu-DOTA-TATE clearly show that the peptide dose and dose in GBq can be varied. Here we present an overview of the development, formulation and optimisation of 177Lu-DOTA-TATE, mainly addressing radiochemical parameters.

  8. Complex cytokine modulation of a continuous line of mink lung epithelial cells (Mv1Lu).

    PubMed

    Kelley, J; Baldor, L; Absher, M

    1992-01-01

    The continuous mink lung epithelial cell line Mv1Lu has proven to be a sensitive reporter line in the bioassay for purified TGF-beta, exhibiting a sigmoid-shaped concentration-response relationship with an EC50 of 12 pM (0.3 ng/mL). Maximal inhibition of Mv1Lu cells generates a 75-95% decrement in the number of adherent cells. However, this bioassay is not specific for TGF-beta as originally claimed. Mv1Lu cells are sensitive to other cytokines and substances found in complex biological fluids. In this study the effects of other biological response modifiers in this assay were tested and several were found to have important growth modulatory capacities that confound the quantitation of TGF-beta. EGF, TGF-alpha, fibronectin, and IGF-I all induce Mv1Lu cell proliferation. In contrast, neither PDGF (-AA, -AB, -BB) nor endotoxin (< or = 10 micrograms/mL) affect Mv1Lu cell number. TGF-beta and TNF-alpha at high concentrations (> or = 10 ng/mL) are the only cytokines examined that inhibit Mv1Lu proliferation. TGF-beta decreases final cell number both by preventing mitosis and by inhibition of adherence of cells to the uncoated dish. Several strategies are suggested to assure the specificity of this otherwise convenient bioassay for TGF-beta.

  9. Acceleration on stretched meshes with line-implicit LU-SGS in parallel implementation

    NASA Astrophysics Data System (ADS)

    Otero, Evelyn; Eliasson, Peter

    2015-02-01

    The implicit lower-upper symmetric Gauss-Seidel (LU-SGS) solver is combined with the line-implicit technique to improve convergence on the very anisotropic grids necessary for resolving the boundary layers. The computational fluid dynamics code used is Edge, a Navier-Stokes flow solver for unstructured grids based on a dual grid and edge-based formulation. Multigrid acceleration is applied with the intention to accelerate the convergence to steady state. LU-SGS works in parallel and gives better linear scaling with respect to the number of processors, than the explicit scheme. The ordering techniques investigated have shown that node numbering does influence the convergence and that the orderings from Delaunay and advancing front generation were among the best tested. 2D Reynolds-averaged Navier-Stokes computations have clearly shown the strong efficiency of our novel approach line-implicit LU-SGS which is four times faster than implicit LU-SGS and line-implicit Runge-Kutta. Implicit LU-SGS for Euler and line-implicit LU-SGS for Reynolds-averaged Navier-Stokes are at least twice faster than explicit and line-implicit Runge-Kutta, respectively, for 2D and 3D cases. For 3D Reynolds-averaged Navier-Stokes, multigrid did not accelerate the convergence and therefore may not be needed.

  10. Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer.

    PubMed

    Valta, Maija P; Zhao, Hongjuan; Saar, Matthias; Tuomela, Johanna; Nolley, Rosalie; Linxweiler, Johannes; Sandholm, Jouko; Lehtimäki, Jaakko; Härkönen, Pirkko; Coleman, Ilsa; Nelson, Peter S; Corey, Eva; Peehl, Donna M

    2016-04-01

    LuCaP serially transplantable patient-derived xenografts (PDXs) are valuable preclinical models of locally advanced or metastatic prostate cancer. Using spheroid culture methodology, we recently established cell lines from several LuCaP PDXs. Here, we characterized in depth the features of xenografts derived from LuCaP 136 spheroid cultures and found faithful retention of the phenotype of the original PDX. In vitro culture enabled luciferase transfection into LuCaP 136 spheroids, facilitating in vivo imaging. We showed that LuCaP 136 spheroids formed intratibial, orthotopic, and subcutaneous tumors when re-introduced into mice. Intratibial tumors responded to castration and were highly osteosclerotic. LuCaP 136 is a realistic in vitro-in vivo preclinical model of a subtype of bone metastatic prostate cancer.

  11. Effects of Lu and Ni Substitution on Thermoelectric Properties of Ca3Co4O9+ δ

    NASA Astrophysics Data System (ADS)

    Yang, Wenchao; Qian, Haoji; Gan, Jinyu; Wei, Wei; Wang, Zhihe; Tang, Guodong

    2016-08-01

    Effects of (Lu, Ni) co-doping on the thermoelectric properties of Ca3Co4O9+ δ (CCO) have been systematically investigated from 20 K to 350 K. The electrical resistivity and thermopower of (Lu, Ni) co-doped samples increase, while their thermal conductivity is significantly depressed as compared to that of pristine CCO. The figure of merit ( ZT) of co-doped samples is higher than those of Lu-doped samples and pristine CCO. A maximum ZT of 0.0185 is achieved at 350 K for Ca2.9Lu0.1Co3.9Ni0.1O9+ δ . We demonstrate that the simultaneous increase of spin entropy and phonon scattering induced by (Lu, Ni) co-doping boosts ZT of CCO. This study indicates that (Lu, Ni) co-doping may promise an effective way to improve thermoelectric properties of the CCO system.

  12. Physical optimization of production by deuteron irradiation of high specific activity (177g)Lu suitable for radioimmunotherapy.

    PubMed

    Manenti, Simone; Bonardi, Mauro L; Gini, Luigi; Groppi, Flavia

    2014-01-01

    Deuteron-induced nuclear reactions for generation of no-carrier-added (NCA) Lu isotopes were investigated using the stacked-foil activation technique on natural Yb targets at energies up to Ed=18.18MeV. The decay curve of ¹⁷⁷Yb, the growth curve of the cumulative (direct and indirect) and the direct production of (177g)Lu were determined. The analysis of these curves conducts to the evidence that the predominant route for the production of (177g)Lu is the indirect reaction ¹⁷⁶Yb(d,p)¹⁷⁷Yb, which decays to (177g)Lu. In the spectra acquired one year from the EOB the γ lines of (177m)Lu are not evident. A comparison between the calculated activity of (177g)Lu produced with a cyclotron and with a nuclear reactor is given.

  13. LU-HF Age of Martian Meteorite Larkman Nunatek 06319

    NASA Technical Reports Server (NTRS)

    Shafer, J. T.; Brandon, A. D.; Lapen, T. J.; Righter, M.; Beard, B.; Peslier, A. H.

    2009-01-01

    Lu-Hf isotopic data were collected on mineral separates and bulk rock powders of LAR 06319, yielding an age of 197+/- 29 Ma. Sm-Nd isotopic data and in-situ LA-ICP-MS data from a thin section of LAR 06319 are currently being collected and will be presented at the 2009 LPSC. These new data for LAR 06319 extend the existing data set for the enriched shergottite group. Martian meteorites represent the only opportunity for ground truth investigation of the geochemistry of Mars [1]. At present, approximately 80 meteorites have been classified as Martian based on young ages and distinctive isotopic signatures [2]. LAR 06319 is a newly discovered (as part of the 2006 ANSMET field season) martian meteorite that represents an important opportunity to further our understanding of the geochemical and petrological constraints on the origin of Martian magmas. Martian meteorites are traditionally categorized into the shergottite, nakhlite, and chassignite groups. The shergottites are further classified into three distinct isotopic groups designated depleted, intermediate, and enriched [3,4] based on the isotope systematics and compositions of their source(s).

  14. Non-magnetic and magnetic impurity effects on superconductivity in the ternary iron-silicide Lu2FeSi

    NASA Astrophysics Data System (ADS)

    Watanabe, Tadataka; Okuyama, Hiroaki; Takase, Kouichi; Takano, Yoshiki

    2010-12-01

    We studied effect of non-magnetic and magnetic impurities on superconductivity in LuFeSi by investigating superconducting properties of (LuFeSi (R=Sc,Y, and Dy). The rapid depression of Tc by non-magnetic impurities reveals strong pair breaking by disorder, providing compelling evidence for the sign reversal of the superconducting order parameter in LuFeSi.

  15. Potential therapeutic radiotracers: preparation, biodistribution and metabolic characteristics of 177Lu-labeled cyclic RGDfK dimer.

    PubMed

    Shi, Jiyun; Liu, Zhaofei; Jia, Bing; Yu, Zilin; Zhao, Huiyun; Wang, Fan

    2010-06-01

    In this study, we reported the preparation and evaluation of (177)Lu-DOTA-RGD2, (177)Lu-DOTA-Bz-RGD2 and (177)Lu-DTPA-Bz-RGD2 (RGD2 = E[c(RGDfK)](2)) as a potential therapeutic radiotracers for the treatment of integrin alpha(v)beta(3)-positive tumors. The BALB/c nude mice bearing the U87MG human glioma xenografts were used to evaluate the biodistribution characteristics and excretion kinetics of (177)Lu-DOTA-RGD2, (177)Lu-DOTA-Bz-RGD2 and (177)Lu-DTPA-Bz-RGD2. It was found that there were no major differences in their lipophilicity and biodistribution characteristics, particularly at latter time points. A major advantage of using DTPA-Bz as the bifunctional chelator (BFC) was its high radiolabeling efficiency (fast and high yield radiolabeling) at room temperature. Using DOTA and DOTA-Bz as BFCs, the radiolabeling kinetics was slow, and heating at 100 degrees C and higher DOTA-conjugate concentration were needed for successful (177)Lu-labeling. Therefore, DTPA-Bz is an optimal BFC for routine preparation of (177)Lu-labeled cyclic RGDfK peptides, and (177)Lu-DTPA-Bz-RGD2 is worthy of further investigation for targeted radiotherapy of integrin alpha(v)beta(3)-positive tumors.

  16. Blocking of lung endothelial cell adhesion molecule-1 (Lu-ECAM-1) inhibits murine melanoma lung metastasis.

    PubMed

    Zhu, D; Cheng, C F; Pauli, B U

    1992-06-01

    The 90-kD lung endothelial cell adhesion molecule-1 (Lu-ECAM-1) selectively promotes Ca(2+)-dependent adhesion of lung-metastatic B16 melanoma cells. Corresponding with their metastatic performance, high lung-metastatic B16-F10 melanoma cells bind in significantly higher numbers to Lu-ECAM-1 than their intermediate and low lung-metastatic counterparts B16-L8-F10 and B16-F0, respectively. Maximum attachment is observed at a density of approximately 2.4 x 10(2) Lu-ECAM-1 sites/microns2 of plastic surface. B16 melanoma cell binding to Lu-ECAM-1 is blocked by mAb 6D3 and is competitively inhibited by soluble Lu-ECAM-1. C57B1/6 mice passively immunized with anti-Lu-ECAM-1 mAb 6D3 or actively immunized with purified Lu-ECAM-1 exhibit an anti-Lu-ECAM-1 antibody titer-dependent reduction in the number of B16 experimental metastases. Lu-ECAM-1 promotes neither binding nor metastasis of other lung-metastatic tumor cells (e.g., KLN205). Our data indicate that an "antiadhesion" therapy directed at interfering with the adherence of blood-borne tumor cells to organ-specific vascular endothelium is efficient in the control of metastasis formation in selective organ sites.

  17. Blocking of lung endothelial cell adhesion molecule-1 (Lu-ECAM-1) inhibits murine melanoma lung metastasis.

    PubMed Central

    Zhu, D; Cheng, C F; Pauli, B U

    1992-01-01

    The 90-kD lung endothelial cell adhesion molecule-1 (Lu-ECAM-1) selectively promotes Ca(2+)-dependent adhesion of lung-metastatic B16 melanoma cells. Corresponding with their metastatic performance, high lung-metastatic B16-F10 melanoma cells bind in significantly higher numbers to Lu-ECAM-1 than their intermediate and low lung-metastatic counterparts B16-L8-F10 and B16-F0, respectively. Maximum attachment is observed at a density of approximately 2.4 x 10(2) Lu-ECAM-1 sites/microns2 of plastic surface. B16 melanoma cell binding to Lu-ECAM-1 is blocked by mAb 6D3 and is competitively inhibited by soluble Lu-ECAM-1. C57B1/6 mice passively immunized with anti-Lu-ECAM-1 mAb 6D3 or actively immunized with purified Lu-ECAM-1 exhibit an anti-Lu-ECAM-1 antibody titer-dependent reduction in the number of B16 experimental metastases. Lu-ECAM-1 promotes neither binding nor metastasis of other lung-metastatic tumor cells (e.g., KLN205). Our data indicate that an "antiadhesion" therapy directed at interfering with the adherence of blood-borne tumor cells to organ-specific vascular endothelium is efficient in the control of metastasis formation in selective organ sites. Images PMID:1601982

  18. Polymorphism, phase transitions, and thermal expansion of K3Lu(PO4)2

    SciTech Connect

    Farmer, James Matthew; Boatner, Lynn A; Chakoumakos, Bryan C; Rawn, Claudia J.; Mandrus, D.; Bryan, Jeff C.

    2014-01-01

    Alkali rare-earth double phosphates have been studied for use as long-wavelength scintillators for -ray detection using Si photodiodes. Single-crystal and powder x-ray diffraction (XRD) and powder neutron diffraction have been used to study the structure as a function of temperature. K3Lu(PO4)2 crystallizes with a hexagonal unit cell at room temperature, space group P 3. The Lu ion is six-coordinated to the oxygen atoms of the phosphate groups. Two lower-temperature phases were characterized using single-crystal XRD and powder neutron diffraction. The first transition occurs at 230 K with a transformation to a monoclinic P21/m space group symmetry, and the Lu retains six coordination. The second phase transition occurs at 130 K, with a large change in the cell volume, keeping the same P21/m space group symmetry; however, one of the phosphate groups rotates to increase the coordination of the Lu ion to seven. This is an unusual example of an isosymmetric phase transition with a coordination change, driven by temperature. High-temperature powder neutron diffraction and high-temperature powder XRD have been used to study the thermal expansion of K3Lu(PO4)2 and indicate a large thermal expansion anisotropy. The crystallographic axes with largest changes account for the structural collapse, which rotates the phosphate group to increase the Lu coordination. The lowest temperature form of K3Lu(PO4)2 is the same as the room temperature form for all the lighter RE compounds of the same type, which is not surprising, given the lighter (larger) RE ions would prefer a higher coordination number.

  19. Isotope effect in charge transport of LuB{sub 12}

    SciTech Connect

    Sluchanko, N. E. Azarevich, A. N.; Bogach, A. V.; Glushkov, V. V.; Demishev, S. V.; Kuznetsov, A. V.; Lyubshov, K. S.; Filippov, V. B.; Shitsevalova, N. Yu.

    2010-08-15

    The galvanomagnetic properties of single-crystal samples with various isotopic boron compositions have been investigated for the first time for the normal state of superconductor LuB{sub 12} (Tc {approx} 0.44 K). Precision measurements of the resistivity, Hall coefficient, and magnetic susceptibility have been performed over a wide temperature range of 2-300 K in magnetic fields up to 80 kOe. A change of the charge transport regime in this nonmagnetic compound with metallic conduction is shown to occur near T* {approx} 50-70 K. As a result, a sharp peak with significantly different amplitudes for Lu{sup 10}B{sub 12} and Lu{sup 11}B{sub 12} is recorded in the temperature dependences of the Hall coefficient R{sub H}(T) near T*. A significant (about 10%) difference (in absolute value) of the Hall coefficients R{sub H} for the Lu{sup 10}B{sub 12} and Lu{sup 11}B{sub 12} compounds at helium and intermediate temperatures has been found and the patterns of behavior of the dependence R{sub H}(H) for T < T* in an external magnetic field H {<=} 80 kOe for Lu{sup 10}B{sub 12} and Lu{sup 11}B{sub 12} are shown to differ significantly. Analysis of the Curie-Weiss contribution to the magnetic susceptibility {chi}(T) leads to the conclusion about the formation of magnetic moments {mu}{sub eff} {approx} (0.13-0.19){mu}{sub B} in each unit cell of the fcc structure of LuB{sub 12} compounds with various isotopic compositions. The possibility of the realization of an electronic topological 2.5-order transition near T* and the influence of correlation effects in the 5d-band on the formation of a spin polarization near the rare-earth ions in LuB{sub 12} is discussed.

  20. Photoactivation of 176mLu via Bremsstrahlung at the Stuttgart DYNAMITRON

    NASA Astrophysics Data System (ADS)

    Goddard, Brian; Henry, Tom; Balint, Trevor; Pitz, Heinz-Hermann; Stedile, Frank; Kneissl, Ulrich; Gaison, Jeremy; Winick, Tristan; Carroll, James

    2014-09-01

    Though unstable, the ground state of 176Lu has a very long half-life of approximately 37 billion years and primarily β- decays (>99.9%) to 176Hf. However, 176Lu possesses an isomer (Jπ = 7-) 123 keV above the ground state (Jπ = 1-) that also β- decays to 176Hf but with a much shorter half-life of about 3.6 hours. The study of this isomer could lead to new findings regarding astrophysical nucleosynthesis. A disparity between the predicted abundance of 176Lu due to nucleosynthesis and the actual measured abundance implies that transitions from the isomer to the ground state via intermediate states must have taken place during the s-process. Since the rates at which these transitions occur are temperature dependent, 176Lu could be used as an s-process ``thermometer.'' A photoactivation experiment was performed on 176Lu at the Stuttgart DYNAMITRON using bremsstrahlung with varying endpoints between 0.7 and 2.2 MeV to determine the intermediate state energies and integral cross sections for the transitions that lead to the isomer. We present the results of the analysis of the data as well as preliminary values for the intermediate state energies and their cross sections.

  1. Production of {sup 177}Lu, a potential radionuclide for diagnostic and therapeutic applications

    SciTech Connect

    Khandaker, Mayeen Uddin; Kassim, Hasan Abu; Haba, Hiromitsu

    2015-04-24

    {sup 177g}Lu (T{sub 1/2}=6.647d; E{sub β{sup −max}}=498.3KeV, I{sub β{sup −total}}=100%; E{sub γ} = 112.9498 keV, I{sub γ} = 6.17%; E{sub γ} = 208.3662 keV, I {sub γ} = 10.36%) is widely used in many clinical procedures due to its excellent decay characteristics. Production cross-sections of the {sup nat}Yb(d,x){sup 177g}Lu reactions have been measured from a 24-MeV deuteron energy down to the threshold by using a stacked-foil activation technique combined with high resolution γ-ray spectrometry. An overall good agreement is found with some of the earlier measurements, whereas a partial agreement is obtained with the theoretical data extracted from the TENDL-2013 library. Physical thick target yield for the {sup 177g}Lu radionuclide was deduced using the measured cross-sections. The deduced yield curves indicate that a low energy (<11 MeV) cyclotron and a highly enriched {sup 176}Yb target could be used to obtain {sup 177g}Lu with negligible impurity from {sup 177m}Lu.

  2. A routine high-precision method for Lu-Hf isotope geochemistry and chronology

    USGS Publications Warehouse

    Patchett, P.J.; Tatsumoto, M.

    1981-01-01

    A method for chemical separation of Lu and Hf from rock, meteorite and mineral samples is described, together with a much improved mass spectrometric running technique for Hf. This allows (i) geo- and cosmochronology using the176Lu???176Hf+??- decay scheme, and (ii) geochemical studies of planetary processes in the earth and moon. Chemical yields for the three-stage ion-exchange column procedure average 90% for Hf. Chemical blanks are <0.2 ng for Lu and Hf. From 1 ??g of Hf, a total ion current of 0.5??10-11 Ampere can be maintained for 3-5 h, yielding 0.01-0.03% precision on the ratio176Hf/177Hf. Normalisation to179Hf/177Hf=0.7325 is used. Extensive results for the Johnson Matthey Hf standard JMC 475 are presented, and this sample is urged as an international mass spectrometric standard; suitable aliquots, prepared from a single batch of JMC 475, are available from Denver. Lu-Hf analyses of the standard rocks BCR-1 and JB-1 are given. The potential of the Lu-Hf method in isotope geochemistry is assessed. ?? 1980 Springer-Verlag.

  3. Spectral and structural features of Lu1 - x RE x BO3 compounds

    NASA Astrophysics Data System (ADS)

    Shmurak, S. Z.; Kedrov, V. V.; Kiselev, A. P.; Fursova, T. N.; Shmyt'ko, I. M.

    2015-08-01

    The luminescence spectra, luminescence excitation spectra, IR absorption spectra, and crystal structure of orthoborates Lu1 - x RE x BO3 ( RE = Eu, Gd, Tb, Y, Dy) have been investigated. It has been found that the solid solution consisting of a LuBO3 orthoborate, which has two stable structural modifications (calcite and vaterite), and an REBO3 orthoborate, which has one structural modification (vaterite), crystallizes only in the vaterite structure when the concentration of a rare-earth ion substituting for lutetium exceeds 15-20 at %. The investigation of the photoluminescence spectra has demonstrated that, for rare-earth ions Lu3+, Eu3+, Y3+, and Gd3+ in the vaterite modification of Lu1 - x RE x BO3 orthoborates, there are at least two positions that are not equivalent in the symmetry of the local environment. It has been established that the maximum intensity of the luminescence of the vaterite modification of Lu1 - x Tb x BO3 compounds synthesized at 970°C, which is observed at a terbium concentration of 15 at %, is several times higher than the maximum intensity of the luminescence of the calcite modification.

  4. Spectral characteristics of different structural modifications of Lu1 - x Eu x BO3

    NASA Astrophysics Data System (ADS)

    Shmurak, S. Z.; Kedrov, V. V.; Kiselev, A. P.; Smyt'ko, I. M.

    2015-01-01

    The spectral and structural characteristics of polycrystals of Eu3+-doped lutetium borates Lu1 - x Eu x BO3) annealed at different temperatures have been investigated over a wide range of europium concentrations. The conditions for the preparation of Lu1 - x Eu x BO3 in the calcite and vaterite phases have been determined. It has been found that there is a radical difference between the excitation spectra of the main emission bands of the calcite and vaterite phases of the Lu1 - x Eu x BO3 borates. The influence of the europium concentration on the structure of Lu1 - x Eu x BO3 has been analyzed. It has been established that, at europium concentrations of higher than 15 at %, only the vaterite structure is formed independently of the annealing temperature. Thus, by varying the Eu3+ concentration and the annealing temperature of Lu1 - x Eu x BO3, it is possible to directionally synthesize a specific structural modification and, consequently, to control the spectral characteristics of this compound.

  5. Pressure induced phase transition and thermo-physical properties in LuX (X = N, P)

    NASA Astrophysics Data System (ADS)

    Sahoo, B. D.; Mukherjee, D.; Joshi, K. D.; Kaushik, T. C.; Gupta, Satish C.

    2016-04-01

    Detailed total energy calculations have been performed in lutetium pnictides (LuX, where X = N, P) to understand their high pressure structural stability. In LuN, the ambient rocksalt type structure (B1 phase) transforms to a tetragonal structure (B10 phase) at ˜240 GPa; whereas in LuP the orthorhombic structure (B33, space group Cmcm) emerges as a high pressure structure above 48 GPa. Both the transitions are found to be of first-order type with volume discontinuities of ˜6% and 8.2%, respectively. The high pressure phases B10 and B33 are found to be stable up to 400 GPa, respectively. Further, the structural stability predicted from static lattice calculations has been supported by lattice dynamical stability analysis. The present calculations rule out the B1 to B2 (CsCl type) structural phase transitions predicted to occur at 241 GPa in LuN and at 98 GPa in LuP by previous all-electron calculations (Gupta and Bhat 2013 J. Mol. Model 19 5343-54). The temperature dependence of several thermo-physical properties such as volume, bulk modulus, specific heat and thermal expansion coefficient of the rocksalt structure of these compounds calculated in the present study, using quasi-harmonic approximation, awaits confirmation by experimental studies.

  6. Synthesis and radiation tolerance of Lu2-xCexTi2O7 pyrochlores

    NASA Astrophysics Data System (ADS)

    Xia, Y.; Liu, C. G.; Yang, D. Y.; Wen, J.; Liu, H.; Mu, P. C.; Li, Y. H.

    2016-11-01

    As a nonradioactive surrogate for Pu, Ce is selected to study the solubility and radiation tolerance in pyrochlore matrixes. In this paper, we synthesized a series of Lu2-xCexTi2O7 (x = 0-0.7) samples. X-ray diffraction, X-ray photoelectron spectroscopy and Raman spectroscopy were used to study the structure of Lu2-xCexTi2O7 (x = 0-0.7) with different Ce3+ content x. The results show that the maximum solubility of Ce3+ in Lu2Ti2O7 is 32 mol%. In order to study the radiation tolerance of these compounds, 400 keV Ne2+ was used to perform the irradiation experiments. The grazing incident X-ray diffraction patterns revealed that the radiation tolerance of the Lu2-xCexTi2O7 decreases with increasing Ce-content. This correlation between radiation tolerance and Ce-content was interpreted in terms of the antisite defect formation energies of Lu2-xCexTi2O7 (x = 0, 0.5, 1) based on the density functional theory.

  7. Crystal structure, physical properties and bond valence analysis of NaLuP2O7

    NASA Astrophysics Data System (ADS)

    Béjaoui, Anis; Horchani-Naifer, Karima; Hajji, Mounir; Férid, Mokhtar

    2014-05-01

    Single crystals of a diphosphate NaLuP2O7 have been synthesized by the flux method and characterized by single-crystal X-Ray diffraction. NaLuP2O7 crystallizes in the monoclinic system with P21/n space group with cell parameters: a = 8.9985(8) Å, b = 5.3473(5) Å, c = 12.756(1) Å, β = 103.174° (1), V = 597.67 (9) Å3, Z = 4. Its structure consists of a three-dimensional framework of P2O7 units that are corner-shared by LuO6 octahedra, forming tunnels running parallel to [010] which are occupied by Na atoms. NaLuP2O7 powder was characterized by XRD, SEM, FTIR and Raman spectroscopy. The activation energy of (1.49 eV) obtained by electrical measurements suggests the charge carriers to be the sodium cations. The activation energies obtained from impedance and loss spectra were analyzed in order to explain the mechanism of conduction. The correlation between ionic conductivity of NaLuP2O7 and its crystallographic structure was investigated and the most probable transport pathway model was determined.

  8. Raman and structural characterization of LuAlO{sub 3}

    SciTech Connect

    Casu, Alberto; Ricci, Pier Carlo

    2011-11-15

    The structural and vibrational properties of lutetium orthoaluminate perovskite (LuAlO{sub 3}) were investigated by means of Raman spectroscopy and EXAFS measurements. The analysis of Raman spectra taken in four different polarized configurations along the principal axes at 20 K and room temperature conditions permits to assign the principal vibrational modes in LuAP single crystals and to confirm the belonging to the D{sub 2h}{sup 16} space group. EXAFS measurements were performed at room temperature in order to obtain local structural informations on the first and next nearest neighbors around lutetium absorptions sites. Unit cell parameters and bond lengths were determined by the analysis of the EXAFS spectroscopy at the L{sub 3} absorption edge of lutetium. The informations thus gathered on this compound can offer a useful addition in the framework of a full structural characterization of LuAlO{sub 3}. - Graphical abstract: Raman active mode in LuAP crystal. Highlights: > Structural characterization of LuAlO{sub 3} is obtained by Raman and EXAFS spectroscopies. > Vibrational modes, temperature-dependent variations studied by Raman spectroscopy. > Cell parameters and local characterization obtained by EXAFS spectroscopy.

  9. Lu2O3:Eu scintillator screen for x-ray imaging

    NASA Astrophysics Data System (ADS)

    Miller, Stuart R.; Nagarkar, Vivek V.; Tipnis, Sameer V.; Shestakova, Irina; Brecher, Charles; Lempicki, Alexander; Lingertat, Helmut

    2004-01-01

    We report on a new x-ray converter screen based on the powdered Lu2O3:Eu scintillator. Lu2O3:Eu offers high density (9.4 g/cm3), high average atomic number (63), and a peak emission of 610 nm. The high density of the material and a high packing fraction of the coating provide higher x-ray absorption efficiency, even with thin screens. As a result Lu2O3:Eu screens are expected to provide superior spatial resolution and x-ray stopping power compared to commercial powdered screens. This newly developed screen has excellent imaging performance and offers several practical advantages such as ease of fabrication, low cost, and durability. This paper will discuss preliminary results of the imaging performance of this novel screen.

  10. The success and complementarity of Sm-Nd and Lu-Hf garnet geochronology

    NASA Astrophysics Data System (ADS)

    Baxter, E. F.; Scherer, E. E.

    2013-12-01

    Garnet's potential as a direct chronometer of tectonometamorphic processes and conditions was first realized over 30 years ago. Since then, the Sm-Nd and Lu-Hf systems have emerged as the most effective, with both permitting age precision < ×1 Myr. Both have proven successful not merely in dating garnet growth itself, but rather in constraining the ages, durations, and rates of particular earth processes or conditions that can be directly linked to garnet growth via chemical, thermodynamic, or petrographic, means. Appreciating important differences between Sm-Nd and Lu-Hf in terms of contaminant phases, partitioning, daughter element diffusivity, and isotopic analysis makes these two systems powerfully complementary when used and interpreted in concert. Well established, robust analytical methods mitigate the effects of ubiquitous mineral inclusions (monazite is most significant for Sm-Nd; zircon is most significant for Lu-Hf), improving the precision and accuracy of garnet dates from both systems. Parent-daughter ratios tend to be higher for Lu-Hf leading to the potential for better age precision in general. The Lu-176 decay rate is faster than Sm-147, meaning that Lu-Hf provides better age precision potential for young (Cenozoic) samples. However, Sm-Nd provides better precision potential for older (Precambrian) samples primarily because of the higher precisions on the parent-daughter ratios (i.e., 147Sm/144Nd) that can be achieved by ID-TIMS analysis. For dating microsampled zones or growth rings in single garnet crystals, Sm-Nd has proven most successful owing to more uniform distribution of Sm, and established methods to measure <10 ng quantities of Nd at high precision via TIMS. However, new MC-ICP-MS sample introduction technologies are closing this gap for small samples. For analyses of bulk garnet that grew over a protracted interval, Lu-Hf dates are expected to be older than Sm-Nd dates owing to differences in Lu and Sm zonation (i.e. Lu tends to be

  11. The stability and surface termination of hexagonal LuFeO3.

    PubMed

    Cao, Shi; Paudel, Tula R; Sinha, Kishan; Jiang, Xuanyuan; Wang, Wenbin; Tsymbal, Evgeny Y; Xu, Xiaoshan; Dowben, Peter A

    2015-05-01

    The surface termination and the nominal valence states for hexagonal LuFeO3 thin films grown on Al2O3(0 0 0 1) substrates were characterized by angle resolved x-ray photoemission spectroscopy. The Lu 4f, Fe 2p and O 1s core level spectra indicate that both the surface termination and the nominal valence depend on surface preparation, but the stable surface terminates in a Fe-O layer. This is consistent with the results of density functional calculations which predict that the Fe-O termination of LuFeO3(0 0 0 1) surface is energetically favorable and stable over a broad range of temperatures and oxygen partial pressures when it is reconstructed to eliminate surface polarity. PMID:25791898

  12. Effect of lu-duo-wei on scavenging superoxide and hydroxyl radicals in vitro.

    PubMed

    Fang, Y Z; Sun, C P; Tian, X H; Cong, J H

    1998-01-01

    Irradiation of a riboflavin-containing system by ultraviolet light was used to produce superoxide radical (.O2-). Hydroxyl radical (.OH) was generated by the system of Fe(II)-H2O2. Using electron spin resonance and spin trapping techniques, the effect of Lu-Duo-Wei, a capsule consisting extracts of green tea, Fructus Lycii and Semen Ziziphi Spinosae, on scavenging .O2- and .OH was observed. The results showed that the efficiency of scavenging .O2- and .OH by Lu-Duo-Wei was much higher than that by tea polyphenol alone. It is suggested that the synergistic action of tea polyphenol and other components are responsible for the scavenging effect of Lu-Duo-Wei on .O2- and .OH. PMID:9799967

  13. Scintillation properties of a La, Lu-admix gadolinium pyrosilicate crystal

    NASA Astrophysics Data System (ADS)

    Kurosawa, Shunsuke; Shishido, Toetsu; Suzuki, Akira; Sugawara, Takamasa; Nomura, Akiko; Yubuta, Kunio; Shoji, Yasuhiro; Yokota, Yuui; Pejchal, Jan; Ohashi, Yuji; Kamada, Kei; Yoshikawa, Akira

    2015-06-01

    In order to obtain new scintillator with higher effective atomic number, a pyrosilicate crystal with a composition (Ce0.01, Gd0.54, La0.25, Lu0.20)2Si2O7 (Ce:LaLu-GPS) was grown by the floating zone method. Emission wavelengths of this material were at 370 and 390 nm. Gamma-ray-excited pulse height and scintillation decay measurement showed that Ce:LaLu-GPS had a light output of 34,000±2000 photons/MeV, an FWHM energy resolution of 6.9±0.2%, and the decay time components of 59±1 ns (13%) and 570±20 ns (87%).

  14. Lu-Hf total-rock isochron for the eucrite meteorites

    NASA Technical Reports Server (NTRS)

    Patchett, P. J.; Tatsumoto, M.

    1980-01-01

    The isotope Lu-176 (2.6% of natural lutetium) decays by beta(-) to Hf-176, with a long half life. The first Lu-Hf isochron is presented. The eucrite meteorites, a suite of planetary igneous rocks of known age, 4,550 Myr, define a 10-point total-rock isochron with a slope of 0.0934 + or - 40, leading to a value of 3.53 + or - 0.14 x 10 to the 10th yr for the beta(-) decay half life of Lu-176. The isochron intercept of 0.27973 + or - 12 gives the initial Hf-176/Hf-177 for the inner solar system at the time of accretion.

  15. Standardization and measurement of gamma-ray probability per decay of 177Lu.

    PubMed

    Dias, Mauro S; Silva, Fabrício F V; Koskinas, Marina F

    2010-01-01

    The procedure followed by the Nuclear Metrology Laboratory (LMN), at the Nuclear and Energy Research Institute (IPEN), for the primary standardization of (177)Lu is described. This radionuclide is widely used in radiopharmacy due to its convenient half-life and emitted beta ray energies. The (177)Lu solution was supplied during an international comparison sponsored by BIPM in 2009 and the primary standardization has been accomplished by the 4pibeta-gamma coincidence method using a proportional counter in 4pi geometry coupled with two NaI(Tl) scintillation counters. The beta efficiency was varied by placing Collodion and aluminum absorbers over and under the radioactive source. The (177)Lu calibrated sources were also measured in a previously calibrated HPGe spectrometer, in order to obtain the emission probability per decay for the selected gamma-ray transitions. The experimental extrapolation curves were also compared with Monte Carlo simulations by means of code ESQUEMA developed at the LMN.

  16. Strain dynamics during La2O3/Lu2O3 superlattice and alloy formation

    NASA Astrophysics Data System (ADS)

    Proessdorf, André; Niehle, Michael; Grosse, Frank; Rodenbach, Peter; Hanke, Michael; Trampert, Achim

    2016-06-01

    The dynamics of strain relaxation and intermixing during molecular beam epitaxy of La2O3 and Lu2O3 superlattices and alloys consisting of both binaries on Si(111) have been studied by real-time in situ grazing incidence x-ray diffraction and high resolution transmission electron microscopy. The presence of both hexagonal and cubic polymorphs of La2O3 influences the epitaxial formation within the superlattice. The process of strain relaxation is closely related to the presence of a (La,Lu)2O3 alloy adopting a cubic symmetry. It is formed by interdiffusion of La and Lu atoms reducing internal lattice mismatch within the superlattice. An interface thickness dominated by interdiffusion regions of about 3 monolayers is determined by high-angle annular dark field scanning transmission electron microscopy.

  17. Preparation and Photoluminescence Properties of Ti-Doped Lu2O3 Powder

    NASA Astrophysics Data System (ADS)

    Zeng, G.; Dong, Q.; Bao, W.

    2016-07-01

    A series of Lu2O3:Ti powders was prepared via a co-precipitation route. With the help of X-ray diffraction analysis (XRD), the phase transition temperature of 773 K is confirmed for the powders. It is difficult to reduce the Ti4+ ions in the powders to Ti3+ ions in H2 atmosphere even if the calcination temperature reaches 773 K, which is verified by measurements of X-ray photoelectron spectroscopy and electron paramagnetic resonance spectroscopy. The Lu2O3:Ti powders calcined in H2 demonstrate an ability to emit white light under UV light excitation. The spectral analysis of photoluminescence and photoluminescence excitation reveals that the luminescence emission originates from the clusters (Ti4+-F- V Lu ' ' ' , etc.). The results show t hat Ti4+ ion and F center are noteworthy luminescent centers in developing luminescent materials.

  18. Theranostic Radiopharmaceuticals Based on Gold Nanoparticles Labeled with (177)Lu and Conjugated to Peptides.

    PubMed

    Ferro-Flores, Guillermina; Ocampo-García, Blanca E; Santos-Cuevas, Clara L; de María Ramírez, Flor; Azorín-Vega, Erika P; Meléndez-Alafort, Laura

    2015-01-01

    Gold nanoparticles (AuNPs) have been proposed for a variety of medical applications such as localized heat sources for cancer treatment and drug delivery systems. The conjugation of peptides to AuNPs produces stable multimeric systems with target-specific molecular recognition. Lutetium- 177 ((177)Lu) has been successfully used in peptide radionuclide therapy. Recently, (177)Lu-AuNPs conjugated to different peptides have been proposed as a new class of theranostic radiopharmaceuticals. These radioconjugates may function simultaneously as molecular imaging agents, radiotherapy systems and thermal-ablation systems. This article covers advancements in the design, synthesis, physicochemical characterization, molecular recognition assessment and preclinical therapeutic efficacy of gold nanoparticles radiolabeled with (177)Lu and conjugated to RGD (-Arg-Gly-Asp-), Lys(3)-Bombesin and Tat(49-57) peptides.

  19. Theranostic Radiopharmaceuticals Based on Gold Nanoparticles Labeled with (177)Lu and Conjugated to Peptides.

    PubMed

    Ferro-Flores, Guillermina; Ocampo-García, Blanca E; Santos-Cuevas, Clara L; de María Ramírez, Flor; Azorín-Vega, Erika P; Meléndez-Alafort, Laura

    2015-01-01

    Gold nanoparticles (AuNPs) have been proposed for a variety of medical applications such as localized heat sources for cancer treatment and drug delivery systems. The conjugation of peptides to AuNPs produces stable multimeric systems with target-specific molecular recognition. Lutetium- 177 ((177)Lu) has been successfully used in peptide radionuclide therapy. Recently, (177)Lu-AuNPs conjugated to different peptides have been proposed as a new class of theranostic radiopharmaceuticals. These radioconjugates may function simultaneously as molecular imaging agents, radiotherapy systems and thermal-ablation systems. This article covers advancements in the design, synthesis, physicochemical characterization, molecular recognition assessment and preclinical therapeutic efficacy of gold nanoparticles radiolabeled with (177)Lu and conjugated to RGD (-Arg-Gly-Asp-), Lys(3)-Bombesin and Tat(49-57) peptides. PMID:25771363

  20. Disorder-Sensitive Superconductivity and Bonding Network in the Iron-Silicide Superconductor Lu2Fe3Si5

    NASA Astrophysics Data System (ADS)

    Watanabe, Tadataka; Okuyama, Hiroaki; Takase, Kouichi; Takano, Yoshiki; Yoshida, Fumiko; Moriyoshi, Chikako; Kuroiwa, Yoshihiro

    2010-03-01

    Iron silicide superconductor Lu2Fe3Si5 exhibits relatively high Tc = 6.0 K among Fe-based substances. Recent specific heat, penetration depth, and thermal conductivity measurements have provided evidences for the multigap superconductivity. We have studied non-magnetic and magnetic impurity effects on superconductivity in Lu2Fe3Si5 by investigating Tc variations in non-magnetic (Lu1-xScx)2Fe3Si5, (Lu1-xYx)2Fe3Si5 and magnetic (Lu1-xDyx)2Fe3Si5. Small amount of non-magnetic impurities (Sc and Y) on the Lu-site rapidly depresses Tc in accordance with the increase in the residual resistivity. Such a disorder-sensitive superconductivity strongly suggests the sign reversal of the superconducting order parameter. Lu2Fe3Si5 has a complicated crystal structure compared to other multigap superconductors such as MgB2 and iron pnictides. Thus it is important to map out the accurate bonding network in the crystal structure for the better understanding of the electronic structure. We have observed the charge density distribution of Lu2Fe3Si5 by analyzing the synchrotron radiation powder diffraction data using the maximum entropy method/Rietveld method.

  1. Negative thermal expansion and anomalies of heat capacity of LuB50 at low temperatures

    SciTech Connect

    Novikov, V. V.; Zhemoedov, N. A.; Matovnikov, A. V.; Mitroshenkov, N. V.; Kuznetsov, S. V.; Bud'ko, S. L.

    2015-07-20

    Heat capacity and thermal expansion of LuB50 boride were experimentally studied in the 2–300 K temperature range. The data reveal an anomalous contribution to the heat capacity at low temperatures. The value of this contribution is proportional to the first degree of temperature. It was identified that this anomaly in heat capacity is caused by the effect of disorder in the LuB50 crystalline structure and it can be described in the soft atomic potential model (SAP). The parameters of the approximation were determined. The temperature dependence of LuB50 heat capacity in the whole temperature range was approximated by the sum of SAP contribution, Debye and two Einstein components. The parameters of SAP contribution for LuB50 were compared to the corresponding values for LuB66, which was studied earlier. Negative thermal expansion at low temperatures was experimentally observed for LuB50. The analysis of the experimental temperature dependence for the Gruneisen parameter of LuB50 suggested that the low-frequency oscillations, described in SAP mode, are responsible for the negative thermal expansion. As a result, the glasslike character of the behavior of LuB50 thermal characteristics at low temperatures was confirmed.

  2. Marked Response to 177Lu Prostate-Specific Membrane Antigen Treatment in Patient With Metastatic Prostate Cancer.

    PubMed

    Soydal, Cigdem; Ozkan, Elgin; Akyurek, Serap; Kucuk, Nuriye Ozlem

    2016-02-01

    We present pretreatment Ga prostate-specific membrane antigen (PSMA) PET/CT and posttreatment Lu-PSMA whole-body scintigraphy images of a 60-year-old patient with metastatic prostate cancer who is dramatically responding to Lu-PSMA treatment. PMID:26505861

  3. Marked Response to 177Lu Prostate-Specific Membrane Antigen Treatment in Patient With Metastatic Prostate Cancer.

    PubMed

    Soydal, Cigdem; Ozkan, Elgin; Akyurek, Serap; Kucuk, Nuriye Ozlem

    2016-02-01

    We present pretreatment Ga prostate-specific membrane antigen (PSMA) PET/CT and posttreatment Lu-PSMA whole-body scintigraphy images of a 60-year-old patient with metastatic prostate cancer who is dramatically responding to Lu-PSMA treatment.

  4. Characterization of Pr:LuAG scintillating crystals for X-ray spectroscopy

    NASA Astrophysics Data System (ADS)

    Bertoni, R.; Bonesini, M.; Cervi, T.; Clemenza, M.; De Bari, A.; Falcone, A.; Mazza, R.; Menegolli, A.; Nastasi, M.; Rossella, M.

    2016-07-01

    The main features of the Pr doped Lu3Al5O12 (Pr:LuAG) scintillating crystals for X-ray spectroscopy applications have been studied using different radioactive sources and photo-detectors. Pr:LuAG is cheaper, compared to a Germanium detector, but with remarkable properties which make it useful for many applications, from fundamental physics measurements to the PET imaging for medical purposes: high density, elevate light yield, fast response, high energy resolution, no hygroscopicity. A sample of Pr:LuAG crystals with 14 mm×14 mm surface area and 13 mm thickness and a NaI crystal of the same surface and 26 mm thickness used as a reference have been characterized with several radioactive sources, emitting photons in the range 100-1000keV. Different light detectors were adopted for the Pr:LuAG studies, sensitive to its UV emission (peak at 310 nm): a 3 in. PMT (Hamamatsu R11065) and new arrays of Hamamatsu SiPM S13361, with siliconic resin as a window. Preliminary results are presented on the performance of the Pr:LuAG crystals, to be mounted in a 2 × 2 array to be tested in the 2015 run of the FAMU experiment at RIKEN-RAL muon facility. The goal is the detection of the X-rays (around 130 keV) emitted during the de-excitation processes of the muonic hydrogen after the excitation with an IR laser with wavelength set at the resonance of the hyperfine splitting, to measure the muonic atom proton radius with unprecedented precision.

  5. High precision Lu and Hf isotope analyses of both spiked and unspiked samples: A new approach

    NASA Astrophysics Data System (ADS)

    Lapen, Thomas J.; Mahlen, Nancy J.; Johnson, Clark M.; Beard, Brian L.

    2004-01-01

    The functional form of instrumentally produced mass fractionation associated with MC-ICP-MS analysis is not accurately known and therefore cannot be fully corrected by traditional approaches of internal normalization using power, linear, or exponential mass-bias laws. We present a method for robust correction of instrumentally produced mass-fractionation of both spiked and unspiked samples that can be applied to mass analysis of Hf as well as Nd, Sr, Os, etc. Correction of 176Hf/177Hf for unspiked samples follows a traditional approach of internal normalization using an exponential law, followed by normalization to a standard of known composition, such as JMC-475. For spiked samples, standards are used to characterize a linear instrumental mass-bias coefficient; the mass-bias coefficient is defined by the slope of a tie-line between measured and true values of a standard. This approximation results in identical precision and accuracy of measurements for spiked and unspiked samples (±0.005% 2σ, external reproducibility). The effects of the spike on the 176Hf/177Hf ratio and calculation of the molar spike-sample ratio is determined by a closed-form solution modified from the double-spike approach used for Fe isotope analysis by TIMS [Johnson and Beard, 1999]. The measured 176Lu/175Lu ratios are corrected by doping the sample with Er and using the 167Er/166Er ratio to externally normalize the 176Lu/175Lu ratio using an exponential law. Finally, spike-sample equilibration is confirmed for our sample dissolution protocol through analysis of varying physical mixtures of 1 Ga garnet and hornblende, where all the data lie on a mixing-line, within error, on a 176Lu/177Hf-176Hf/177Hf diagram. Precision of 176Lu/177Hf ratios is determined to be ±0.2% (2σ) for standards and for physical mixtures of garnet and hornblende.

  6. First laser operation and spectroscopic characterization of mixed garnet Yb:LuYAG ceramics

    NASA Astrophysics Data System (ADS)

    Toci, Guido; Pirri, Angela; Li, Jiang; Xie, Tengfei; Pan, Yubai; Nikl, Martin; Babin, Vladimir; Beitlerová, Alena; Vannini, Matteo

    2016-03-01

    We present the optical and spectroscopic characterization and the first example of laser operation of Yb doped LuYAG ceramics, with two different compositions, namely (Lu0.25Y0.75)3Al5O12 and (Lu0.50Y0.50)3Al5O12, both with 15% Yb doping. Ceramic samples were prepared by reactive sintering from high purity α-Al2O3, Lu2O3, Y2O3, Yb2O3 powders using Tetraethoxysilane (TEOS) and MgO as sintering aids. After ball milling, the slurry was dried, uniaxially pressed into 20 mm diameter pellets at 20 MPa, and then cold isostatically pressed at 200 MPa. Sintering was conducted at 1850°C for 30 h under vacuum, followed by annealing in air (1500 °C, 10 h) to remove the oxygen vacancies. Laser tests were carried out in a laser cavity end pumped by a fiber coupled diode laser emitting at 936 nm. A slope efficiency as high as 65.2% with a maximum output power of 8.7 W (in quasi-CW pumping conditions) was obtained from the sample with composition (Lu0.25Y0.75)3Al5O12, whereas the sample with composition (Lu0.50Y0.50)3Al5O12 had a maximum slope efficiency of 49.5% (due to the higher scattering losses), and 6.7 W of maximum output power. Furthermore we characterized the tuning range of the two samples.

  7. Polymorphism and phase transitions of K_3Lu(PO_4)_2

    NASA Astrophysics Data System (ADS)

    Farmer, J. Matt; Boatner, Lynn A.; Chakoumakos, Bryan C.; Mandrus, David; Jin, Rongying

    2001-03-01

    Alkali lanthanide double phosphates have been studied for uses as long-wavelength scintillators for γ-ray detection using Si photodiodes. This family of compounds exhibits layered crystal structures, in the sequence lanthanide, phosphate alkali, alkali, alkali - phosphate. Current research has focused on K_3Lu(PO_4)_2. At room temperature, this compound is hexagonal, P 3 space group symmetry. The Lu ion is six-coordinated to the oxygen atoms of the phosphate groups. Our group has recently characterized two lower-temperature phases of K_3Lu(PO_4)2 using single-crystal XRD and powder neutron diffraction. The first transition occurs at 230 K, with a transformation to monoclinic P 2_1/m space group symmetry, and the Lu still retains six coordination. Another transition occurs at 130 K, with a small change in the cell volume, keeping the same P 2_1/m space group symmetry; however, one of the phosphate groups rotates to increase the coordination of the Lu ion to seven. This new structure is isostructural with the room-temperature form of K_3Yb(PO_4)_2. A heat capacity versus temperature study of K_3Lu(PO_4)2 confirms the transformations and indicates a large thermal hysteresis as the crystals are thermally cycled between 15 and 295 K. Research sponsored by the U.S. Department of Energy under contract DE-AC05-00OR22725 with the Oak Ridge National Laboratory, managed by UT-Battelle, LLC.

  8. (177) Lu-5-Fluorouracil a potential theranostic radiopharmaceutical: radiosynthesis, quality control, biodistribution, and scintigraphy.

    PubMed

    Rasheed, Rashid; Tariq, Saleha; Naqvi, Syed Ali Raza; Gillani, Syed Jawad Hussain; Rizvi, Faheem Askari; Sajid, Muhammad; Rasheed, Shahid

    2016-08-01

    The aim of this study is to develop (177) Lu-5-Flourouracil as a potential cancer therapeutic radiopharmaceutical. 5-Flourouracil (5-FU) is widely accepted as an anticancer drug of broad spectrum fame. The labeling of 5-FU was carried out at different set of experimental conditions using high specific activity of (177) LuCl3 . The optimum conditions for maximum radiochemical yield was set: 5-FU (5 mg), (177) LuCl3 (185 MBq), diethylenetriaminepentaacetic acid (10 µg), reaction volume (2 mL), pH (5.5), temperature (80°C), and reaction time (20 min). The radiochemical labeling was assessed with Whatman No. 2 paper, instant thin layer chromatographic, and radio-HPLC, which revealed >94% labeling results with sufficient stability up to 6 h. Serum stability study also showed (177) Lu-5-FU promising stability. Biodistribution study in normal rats and rabbits showed liver, stomach, kidney, and heart as area of increased tracer accumulation just after injection, which decreased to 1.4%, 0.4%, 0.2%, and 0.39% ID/g, respectively, after 72 h. Glomerular filtration rate and cytotoxicity study results of (177) Lu-5-FU showed it had no adverse effect on renal function and nontoxic to blood cells. The promising characteristics of (177) Lu-5-FU, that is, clever elimination from kidney and nontoxic nature toward blood cells make it the radiopharmaceutical for further testing in patients for therapeutic purposes. PMID:27444959

  9. Enhanced Curie temperatures and magnetoelastic domains in Dy/Lu superlattices and films

    NASA Astrophysics Data System (ADS)

    Beach, R. S.; Borchers, J. A.; Matheny, A.; Erwin, R. W.; Salamon, M. B.; Everitt, B.; Pettit, K.; Rhyne, J. J.; Flynn, C. P.

    1993-05-01

    We have grown high quality superlattices of Dy with nonmagnetic Lu and find that the 2.4% epitaxial compression nearly doubles the ferromagnetic Tc of Dy with little change in the Néel temperature. A helimagnetic phase exists over a narrow temperature range. Below Tc in superlattices, 300 Å orthorhombic domains form despite epitaxial constraints, each with a magnetostrictive distortion comparable to that of bulk Dy. For the thinnest intervening Lu layers, individual ferromagnetic Dy blocks have parallel alignment; the remaining samples show antiparallel alignment, coherent over many bilayer periods.

  10. Structural and dielectric properties of the lutetium (Lu) and yttrium (Y) doped nickel ferrite

    SciTech Connect

    Ugendar, Kodam Markandeyulu, G.

    2014-04-24

    The structural and dielectric characteristics of NiFe{sub 1.925}R{sub 0.075}O{sub 4} (R=Lu,Y) were investigated. The material crystallize in the cubic inverse spinel phase with a very small amount of RFeO{sub 3} (R=Lu,Y) as the additional phase. Frequency variation of the dielectric constant shows the dispersion that can be modeled with a modified Debye's function, which considers the possibility of more than one ion, contributing to the relaxation. Impedance spectroscopic analysis indicates the different relaxation mechanisms, bulk grain and grain-boundary contributions to the electrical conductivity and capacitance of these materials.

  11. Three-dimensional magnetic correlations in multiferroic LuFe2O4

    SciTech Connect

    Christianson, Andrew D; Lumsden, Mark D; Angst, Manuel; Yamani, Z.; Tian, Wei; Jin, Rongying; Payzant, E Andrew; Nagler, Stephen E; Sales, Brian C; Mandrus, David

    2008-01-01

    We present single crystal neutron diffraction measurements on multiferroic LuFe{sub 2}O{sub 4}. Magnetic reflections are observed below transitions at 240 and 175 K indicating that the magnetic interactions in LuFe{sub 2}O{sub 4} are three-dimensional in character. The magnetic structure is refined as a ferrimagnetic spin configuration below the 240 K transition. Below 175 K a significant broadening of the magnetic peaks is observed along with the buildup of a diffuse component to the magnetic scattering.

  12. Proton Decay Studies of the Light Lu, Tm and Ho Isotopes

    SciTech Connect

    Akovali, Y.; Batchelder, J.C.; Bingham, C.R.; Davinson, T.; Ginter, T.N.; Gross, C.J.; Grzywacz, R.; Hamilton, J.H.; Janas, Z.; Karny, M.; Kim, S.H.; MacDonald, B.D.; Mas, J.F.; McConnell, J.W.; Piechaczek, A.; Ressler, J.J.; Rykaczewski, K.; Slinger, R.C.; Szerypo, J.; Toth, K.S.; Weintraub, W.; Woods, P.J.; Yu, C.-H.; Zganjar, E.F.

    1998-10-15

    A double-sided Si-strip detector system has been installed and commissioned at the focal plane of the Recoil Mass Spectrometer at the Holifield Radioactive Ion Beam Facility. The system can be used for heavy charged particle emission studies with half-lives as low as a few {micro}sec. In this paper the authors present identification and study of the decay properties of the five new proton emitters: {sup 140}Ho, {sup 141m}Ho, {sup 145}Tm, {sup 150m}Lu and {sup 151m}Lu.

  13. 1.21 W passively mode-locked Tm:LuAG laser.

    PubMed

    Feng, T; Yang, K; Zhao, J; Zhao, S; Qiao, W; Li, T; Dekorsy, T; He, J; Zheng, L; Wang, Q; Xu, X; Su, L; Xu, J

    2015-05-01

    A watt-level output passively mode-locked Tm:LuAG bulk laser with an InGaAs semiconductor saturable absorber mirror (SESAM) is demonstrated for the first time. A maximum average output power of 1.21 W at 2022.9 nm has been achieved with a pulse duration of 38 ps and a repetition rate of 129.2 MHz. The results indicate the potential of Tm:LuAG crystals as candidate for realizing high power ultrafast lasers at 2 μm. PMID:25969273

  14. Proton decay studies of the light Lu, Tm and Ho isotopes

    SciTech Connect

    Batchelder, J. C.; Bingham, C. R.; Gross, C. J.; Grzywacz, R.; Rykaczewski, K.; Toth, K. S.; Zganjar, E. F.; Akovali, Y.; Davinson, T.; Ginter, T. N.

    1999-09-02

    A double-sided Si-strip detector system has been installed and commissioned at the focal plane of the Recoil Mass Spectrometer at the Holifield Radioactive Ion Beam Facility. The system can be used for heavy charged particle emission studies with half-lives as low as a few {mu}sec. In this paper we present identification and study of the decay properties of the five new proton emitters: {sup 140}Ho, {sup 141m}Ho, {sup 145}Tm, {sup 150m}Lu and {sup 151m}Lu. (c) 1999 American Institute of Physics.

  15. The regulation of prostitution in Beyoğlu (1875-1915).

    PubMed

    özbek, Müge

    2010-01-01

    This study examines the development and nature of the regulation of prostitution in Beyoğlu during the late Ottoman Empire with special emphasis on the way the regulationist regime reinforced existing patterns of class and gender domination. The regulation of prostitution became a matter of urgency in the last decades of the nineteenth century in Istanbul, particularly in Beyoğlu, the cosmopolitan centre of the city. Through this process, the protests of the local residents of the area objecting to the proliferation of prostitution in their neighbourhoods played a crucial role in prompting the governmental authorities to tighten the regulations.

  16. Surface and electronic structure of epitaxial PtLuSb (001) thin films

    SciTech Connect

    Patel, Sahil J.; Kawasaki, Jason K.; Logan, John; Schultz, Brian D.; Adell, J.; Thiagarajan, B.; Mikkelsen, A.; Palmstrøm, Chris J.

    2014-05-19

    The surface and electronic structure of single crystal thin films of PtLuSb (001) grown by molecular beam epitaxy were studied. Scanning tunneling spectroscopy (STS), photoemission spectroscopy, and temperature dependent Hall measurements of PtLuSb thin films are consistent with a zero-gap semiconductor or semi-metal. STS and photoemission measurements show a decrease in density of states approaching the Fermi level for both valence and conduction bands as well as a slight shift of the Fermi level position into the valence band. Temperature dependent Hall measurements also corroborate the Fermi level position by measurement of p-type carriers.

  17. Accurate Determination of Radionuclidic Purity and Half-Life of Reactor Produced LU-177G for Metabolic Radioimmunotherapy

    NASA Astrophysics Data System (ADS)

    Groppi, F.; Canella, L.; Bonardi, M. L.; Zona, C.; Morzenti, S.; Menapace, E.; Alfassi, Z. B.; Chinol, M.; Papi, S.; Tosi, G.

    2006-04-01

    The accurate determination of radionuclidic purity and half-life of the beta emitter 177gLu used for metabolic radioimmunotherapy is presented. High-resolution gamma spectrometry, as well as deconvolution of beta decay curve measured by spectrometry with liquid scintillation counting, have been adopted for quality control of different samples available on the market. A simple method was developed to distinguish between the different methods available for production of 177gLu: i.e. either direct (n,γ) reactions of enriched 176Lu or indirect (n,γ) activation of enriched 176Yb followed by β- decay. In the first case, the long-lived metastable level 177mLu is present in the radioactive preparation and a low specific activity radionuclide is obtained, in the latter a very high purity and high specific activity 177gLu is produced.

  18. ¹⁷⁷Lu-Labeled Agents for Neuroendocrine Tumor Therapy and Bone Pain Palliation in Uruguay.

    PubMed

    Balter, Henia; Victoria, Trindade; Mariella, Terán; Javier, Gaudiano; Rodolfo, Ferrando; Andrea, Paolino; Graciela, Rodriguez; Juan, Hermida; Eugenia, De Marco; Patricia, Oliver

    2016-01-01

    Lutetium-177 is an emerging radionuclide due its convenient chemical and nuclear properties. In this paper we describe the development and evaluation in Uruguay of the targeted 177Lu labelled radiopharmaceuticals EDTMP (for bone pain palliation) and DOTA-TATE (neuroendocrine tumors). We optimized the preparation of these 177Lu radiopharmaceuticals including radiolabelling, quality control methods, in vitro and in vivo stability and their therapeutic application in patients. Radiation dosimetry aspects of 177Lu are also included. Nine male patients with prostate cancer and four female patients with breast carcinoma with multiple bone metastatic lesions were treated with 177Lu-EDTMP. Four patients with gastroentheropancreatic neuroendocrine tumors (GEP-NET) and one patient with bronchial NET were treated with 1- 3 cycles with a cumulative dose of 4.44-22.2 GBq of 177Lu-DOTA-TATE. Scintigraphic images of the patients treated with 177Lu-EDTMP evidenced high and rapid uptake in bone metastasis, remaining after 7 days post administration. Images allow skeletal visualization with high definition and demonstrate increased uptake in bone metastases. For 177Lu-DOTA-TATE, partial remissions were obtained in 4 patients and the remaining patient did not show significant progression 3 months after the second cycle. No serious adverse effects were registered, even in two patients with confirmed renal disease and high risk for renal disease Dosimetry assessments confirm the predictive value of the personalized therapy with radiolabelled peptides. We found it is possible to accumulate high therapeutic doses in tumours in sequential administrations of 177Lu-DOTA-TATE, increasing the probability of biological response without significant impairment of the renal function in patients with risk factors. These results demonstrate the attractive therapeutic properties of these two 177Lu labelled agents and the feasibility of this metabolic therapy in regions far away from 177Lu producing

  19. ¹⁷⁷Lu-Labeled Agents for Neuroendocrine Tumor Therapy and Bone Pain Palliation in Uruguay.

    PubMed

    Balter, Henia; Victoria, Trindade; Mariella, Terán; Javier, Gaudiano; Rodolfo, Ferrando; Andrea, Paolino; Graciela, Rodriguez; Juan, Hermida; Eugenia, De Marco; Patricia, Oliver

    2016-01-01

    Lutetium-177 is an emerging radionuclide due its convenient chemical and nuclear properties. In this paper we describe the development and evaluation in Uruguay of the targeted 177Lu labelled radiopharmaceuticals EDTMP (for bone pain palliation) and DOTA-TATE (neuroendocrine tumors). We optimized the preparation of these 177Lu radiopharmaceuticals including radiolabelling, quality control methods, in vitro and in vivo stability and their therapeutic application in patients. Radiation dosimetry aspects of 177Lu are also included. Nine male patients with prostate cancer and four female patients with breast carcinoma with multiple bone metastatic lesions were treated with 177Lu-EDTMP. Four patients with gastroentheropancreatic neuroendocrine tumors (GEP-NET) and one patient with bronchial NET were treated with 1- 3 cycles with a cumulative dose of 4.44-22.2 GBq of 177Lu-DOTA-TATE. Scintigraphic images of the patients treated with 177Lu-EDTMP evidenced high and rapid uptake in bone metastasis, remaining after 7 days post administration. Images allow skeletal visualization with high definition and demonstrate increased uptake in bone metastases. For 177Lu-DOTA-TATE, partial remissions were obtained in 4 patients and the remaining patient did not show significant progression 3 months after the second cycle. No serious adverse effects were registered, even in two patients with confirmed renal disease and high risk for renal disease Dosimetry assessments confirm the predictive value of the personalized therapy with radiolabelled peptides. We found it is possible to accumulate high therapeutic doses in tumours in sequential administrations of 177Lu-DOTA-TATE, increasing the probability of biological response without significant impairment of the renal function in patients with risk factors. These results demonstrate the attractive therapeutic properties of these two 177Lu labelled agents and the feasibility of this metabolic therapy in regions far away from 177Lu producing

  20. Meteorite zircon constraints on the bulk Lu-Hf isotope composition and early differentiation of the Earth.

    PubMed

    Iizuka, Tsuyoshi; Yamaguchi, Takao; Hibiya, Yuki; Amelin, Yuri

    2015-04-28

    Knowledge of planetary differentiation is crucial for understanding the chemical and thermal evolution of terrestrial planets. The (176)Lu-(176)Hf radioactive decay system has been widely used to constrain the timescales and mechanisms of silicate differentiation on Earth, but the data interpretation requires accurate estimation of Hf isotope evolution of the bulk Earth. Because both Lu and Hf are refractory lithophile elements, the isotope evolution can be potentially extrapolated from the present-day (176)Hf/(177)Hf and (176)Lu/(177)Hf in undifferentiated chondrite meteorites. However, these ratios in chondrites are highly variable due to the metamorphic redistribution of Lu and Hf, making it difficult to ascertain the correct reference values for the bulk Earth. In addition, it has been proposed that chondrites contain excess (176)Hf due to the accelerated decay of (176)Lu resulting from photoexcitation to a short-lived isomer. If so, the paradigm of a chondritic Earth would be invalid for the Lu-Hf system. Herein we report the first, to our knowledge, high-precision Lu-Hf isotope analysis of meteorite crystalline zircon, a mineral that is resistant to metamorphism and has low Lu/Hf. We use the meteorite zircon data to define the Solar System initial (176)Hf/(177)Hf (0.279781 ± 0.000018) and further to identify pristine chondrites that contain no excess (176)Hf and accurately represent the Lu-Hf system of the bulk Earth ((176)Hf/(177)Hf = 0.282793 ± 0.000011; (176)Lu/(177)Hf = 0.0338 ± 0.0001). Our results provide firm evidence that the most primitive Hf in terrestrial zircon reflects the development of a chemically enriched silicate reservoir on Earth as far back as 4.5 billion years ago.

  1. Meteorite zircon constraints on the bulk Lu-Hf isotope composition and early differentiation of the Earth.

    PubMed

    Iizuka, Tsuyoshi; Yamaguchi, Takao; Hibiya, Yuki; Amelin, Yuri

    2015-04-28

    Knowledge of planetary differentiation is crucial for understanding the chemical and thermal evolution of terrestrial planets. The (176)Lu-(176)Hf radioactive decay system has been widely used to constrain the timescales and mechanisms of silicate differentiation on Earth, but the data interpretation requires accurate estimation of Hf isotope evolution of the bulk Earth. Because both Lu and Hf are refractory lithophile elements, the isotope evolution can be potentially extrapolated from the present-day (176)Hf/(177)Hf and (176)Lu/(177)Hf in undifferentiated chondrite meteorites. However, these ratios in chondrites are highly variable due to the metamorphic redistribution of Lu and Hf, making it difficult to ascertain the correct reference values for the bulk Earth. In addition, it has been proposed that chondrites contain excess (176)Hf due to the accelerated decay of (176)Lu resulting from photoexcitation to a short-lived isomer. If so, the paradigm of a chondritic Earth would be invalid for the Lu-Hf system. Herein we report the first, to our knowledge, high-precision Lu-Hf isotope analysis of meteorite crystalline zircon, a mineral that is resistant to metamorphism and has low Lu/Hf. We use the meteorite zircon data to define the Solar System initial (176)Hf/(177)Hf (0.279781 ± 0.000018) and further to identify pristine chondrites that contain no excess (176)Hf and accurately represent the Lu-Hf system of the bulk Earth ((176)Hf/(177)Hf = 0.282793 ± 0.000011; (176)Lu/(177)Hf = 0.0338 ± 0.0001). Our results provide firm evidence that the most primitive Hf in terrestrial zircon reflects the development of a chemically enriched silicate reservoir on Earth as far back as 4.5 billion years ago. PMID:25870298

  2. Lu-Hf isotope systematics of fossil biogenic apatite and their effects on geochronology

    NASA Astrophysics Data System (ADS)

    Herwartz, Daniel; Münker, Carsten; Tütken, Thomas; Hoffmann, J. Elis; Wittke, Andreas; Barbier, Bruno

    2013-01-01

    Reliable methods for direct dating of biogenic apatite from pre-Pleistocene fossils are currently not available, and recent attempts using the Lu-Hf decay system yielded highly inaccurate ages for both bones and teeth. The geological processes accounting for this poor accuracy of Lu-Hf chronometry are not yet understood. Here we explore Lu-Hf systematics in fossil bones and teeth in detail, by applying five different sample digestion techniques that are tested on bones and composites of bone and sediment. Our current dataset implies that dissolution methods only slightly affect the resulting Lu-Hf ages, while clear differences between the individual digestion techniques became apparent for element concentrations. By analysing the insoluble leftovers from incomplete sample dissolution, four main reservoirs of Hf in fossil bones were identified: (1) a radiogenic end-member associated with apatite; (2) an unradiogenic end-member represented by the authigenic minerals or the embedding sediment; (3) a highly unradiogenic end-member that can be attributed to detrital zircon; and (4) a moderately soluble phase (probably a Zr(Hf)-phosphate) that yielded very low Lu/Hf but a highly radiogenic Hf isotope composition at the same time. This Zr(Hf)-phase must have been precipitated within the fossil bone sample at a late stage of burial history, thereby incorporating radiogenic 176Hf released from apatite surfaces over geological timescales. A second focus of our study is the effect of different sediment matrices and of crystal size on the preservation of pristine Lu-Hf isotope compositions in bioapatite. Because near-depositional Lu-Hf ages of phosphate fossils have previously been reported for the London Clay (England) and a calcareous marl from Tendaguru (Tanzania), we herein investigate specimens fossilised in carbonate matrices (calcareous marl from Oker, Germany; carbonate concretions from the Santana Formation, Brazil; carbonate from the Eifel, Germany) and argillaceous

  3. Photon scattering experiments on the quasistable, odd-odd mass nucleus Lu176

    NASA Astrophysics Data System (ADS)

    Walter, S.; Stedile, F.; Carroll, J. J.; Fransen, C.; Friessner, G.; Hollmann, N.; von Garrel, H.; Jolie, J.; Karg, O.; Käppeler, F.; Kneissl, U.; Kohstall, C.; von Neumann-Cosel, P.; Linnemann, A.; Mücher, D.; Pietralla, N.; Pitz, H. H.; Rusev, G.; Scheck, M.; Scholl, C.; Schwengner, R.; Werner, V.; Wisshak, K.

    2007-03-01

    The quasistable odd-odd-mass nucleus Lu176 is of special interest in nuclear structure physics and, above all, in nuclear astrophysics. Systematic photon scattering experiments have been performed at the bremsstrahlung facility of the 4.3-MV Stuttgart Dynamitron accelerator with bremsstrahlung end-point energies of 2.3 and 3.1 MeV to determine the low-energy dipole strength distribution in the s-only isotope Lu176. The main goal was to pin down possible intermediate states (IS) for the photoactivation of the short-lived 123-keV isomer, which is the key process determining the effective lifetime of Lu176 in a stellar photon bath and hence for the use of this isotope as a stellar chronometer. Using an enriched sample, 29 transitions ascribed to Lu176 were detected below 2.9-MeV excitation energy. The corresponding excitation strengths were determined. For the previously proposed lowest IS at 839 keV, an upper limit for the excitation strength corresponding to a lifetime of τ⩾ 1.5 ps can be given. Astrophysical consequences, also in view of new Stuttgart photoactivation experiments, are discussed. The fragmentation of the dipole strength is compared to those in neighboring even-even and odd-even nuclei.

  4. A Navier-Stokes solver using the LU-SSOR TVD algorithm

    NASA Technical Reports Server (NTRS)

    Yoon, Seokkwan

    1987-01-01

    A new Navier-Stokes solver is developed by combining the efficiency of the LU-SSOR scheme and the accuracy of the flux-limited dissipation scheme. Application to laminar and turbulent flows and hypersonic flows proves the reliability of the new algorithm.

  5. Near-infrared Downconversion in LuPO4: Tm3+, Yb3+ Phosphors.

    PubMed

    Li, Li; Wang, Yongjie; Shen, Jun; Chang, Wenxuan; Jin, Tianting; Wei, Xiantao; Tian, Ya

    2016-04-01

    Tm3+ and Yb3+ codoped LuPO4 phosphors were synthesized by the reverse-strike co-precipitation method. The obtained LuPO4:Tm3+,Yb3+ phosphors were characterized by X-ray diffraction (XRD), diffuse reflectance spectra, photoluminescence (PL) spectra, and decay lifetime to understand the observed near-infrared downconversion (DC) phenomena. The XRD results show that all the prepared phosphors can be readily indexed to the pure tetragonal phase of LuPO4 and exhibit good crystallinity. The experimental results showed that the strong visible emission around 649 nm from Tm3+(1G4 --> 3F4) and near-infrared (NIR) emission around 1003 nm from Yb3+(2F5/2 --> 2F7/2) of LuPO4:Tm3+,Yb3+ phosphors were observed under 468 nm excitation, respectively. The Yb3+ concentration dependence of luminescent properties and lifetimes of both the visible and NIR emissions have also been investigated. The quenching concentration of Yb3+ ions approaches 30 mol%. The DC mechanism is also discussed in detail. PMID:27451658

  6. Efficient Operation of Conductively Cooled Ho:Tm:LuLiF Laser Oscillator/Amplifier

    NASA Technical Reports Server (NTRS)

    Yu, Jirong; Bai, Yingxin; Trieu, Bo; Petros, M.; Petzar, Paul; Lee, Hyung; Singh, U.

    2008-01-01

    A conductively-cooled Ho:Tm:LuLiF laser oscillator generates 1.6J normal mode pulses at 10Hz with optical to optical efficiency of 20%. When the laser head module is used as the amplifier, the double-pass small-signal amplification excesses 25.

  7. Measurement of 173Lu(n,γ) Cross Sections at DANCE

    NASA Astrophysics Data System (ADS)

    Roig, O.; Theroine, C.; Ebran, A.; Méot, V.; Bond, E. M.; Bredeweg, T. A.; Couture, A.; Haight, R. C.; Jandel, M.; Nortier, F. M.; O'Donnell, J. M.; Rundberg, R. S.; Taylor, W. A.; Ullmann, J. L.; Vieira, D. J.

    2014-05-01

    A highly gamma-radioactive target, 3.7 GBq, of 173Lu isotope was placed inside the DANCE array (Detector for Advanced Neutron Capture Experiments) at Los Alamos to study the radiative neutron capture on an unstable isotope. The 173Lu element was produced by naturalHf(p,xn) reactions following by beta-decays at the Isotope Production Facility (IPF). Measurements of radiative neutron capture cross section on 173Lu were achieved at the Los Alamos Neutron Science Center (LANSCE) spallation neutron source facility over the neutron energy range from thermal up to 1 keV. A special configuration was necessary to perform the experiment using the DANCE [1] array due to the high gamma activity of the target. We will report on the target production, the experiment and the results obtained for the radiative neutron capture on 173Lu. The radiative capture cross section was obtained for the first time on this unstable nucleus. Some resonances have been characterized. A comparison with a recent data evaluation is presented.

  8. Tm:YLF Pumped Ho:YAG and Ho:LuAG Lasers

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.; Reichle, Donald J.; Walsh, Brian M.; Axenson, Theresa J.

    2004-01-01

    Room temperature Ho:YAG and Ho:LuAG lasers pumped by a Tm:YLF laser demonstrated a 3.4 mJ threshold and 0.41 slope efficiency, incident optical to laser output energy. Results for numerous rod lengths, Ho concentrations, and output mirror reflectivities are presented.

  9. ZnO epitaxy on (111) Si using epitaxial Lu2O3 buffer layers

    NASA Astrophysics Data System (ADS)

    Guo, W.; Allenic, A.; Chen, Y. B.; Pan, X. Q.; Tian, W.; Adamo, C.; Schlom, D. G.

    2008-02-01

    We report the growth and characterization of single-crystalline, crack-free, epitaxial (0001) ZnO films on (111) Si substrates using intervening epitaxial Lu2O3 buffer layers. The epitaxial orientation relationships are (0001)ZnO∥(111)Lu2O3∥(111)Si and [12¯10]ZnO∥[1¯10]Lu2O3∥[11¯0]Si. X-ray diffraction and transmission electron microscopy reveal that the ZnO films have high structural quality and an atomically sharp ZnO /Lu2O3 interface. Temperature-dependent photoluminescence measurements show optical properties comparable to ZnO single crystals. The films have a resistivity of 0.31Ωcm, an electron concentration of 2.5×1017cm-3, and a mobility of 80cm2/Vṡs at room temperature. The epitaxial growth of ZnO on Si represents a significant step toward the integration of ZnO-based multifunctional devices with Si electronics.

  10. Weak Antilocalization Effect and Noncentrosymmetric Superconductivity in a Topologically Nontrivial Semimetal LuPdBi

    PubMed Central

    Xu, Guizhou; Wang, Wenhong; Zhang, Xiaoming; Du, Yin; Liu, Enke; Wang, Shouguo; Wu, Guangheng; Liu, Zhongyuan; Zhang, Xi Xiang

    2014-01-01

    A large number of half-Heusler compounds have been recently proposed as three-dimensional (3D) topological insulators (TIs) with tunable physical properties. However, no transport measurements associated with the topological surface states have been observed in these half-Heusler candidates due to the dominating contribution from bulk electrical conductance. Here we show that, by reducing the mobility of bulk carriers, a two-dimensional (2D) weak antilocalization (WAL) effect, one of the hallmarks of topological surface states, was experimentally revealed from the tilted magnetic field dependence of magnetoconductance in a topologically nontrivial semimetal LuPdBi. Besides the observation of a 2D WAL effect, a superconducting transition was revealed at Tc ~ 1.7 K in the same bulk LuPdBi. Quantitative analysis within the framework of a generalized BCS theory leads to the conclusion that the noncentrosymmetric superconductivity of LuPdBi is fully gapped with a possibly unconventional pairing character. The co-existence of superconductivity and the transport signature of topological surface states in the same bulk alloy suggests that LuPdBi represents a very promising candidate as a topological superconductor. PMID:25043549

  11. A new photocatalyst of LuFeO3 for the dye degradation

    NASA Astrophysics Data System (ADS)

    Zhou, M.; Yang, H.; Xian, T.; Zhang, C. R.

    2015-08-01

    A polyacrylamide gel route was introduced to synthesize LuFeO3 particles, where the effects of calcination temperature, calcination time and chelating agent on the products were investigated. By varying the experimental conditions, several LuFeO3 samples with sphere-, ellipsoid- and worm-like morphologies and average particle sizes of 200-270 nm were prepared. The photocatalytic activity of LuFeO3 samples was evaluated by degrading rhodamine B (RhB) under simulated-sunlight irradiation, revealing that they exhibit a pronounced photocatalytic activity. The effects of p-benzoquinone (BQ), ethanol and oxalic acid (OA) on the photocatalytic efficiency were investigated. It is observed that BQ has almost no effect on the photocatalytic degradation of RhB, ethanol exhibits a substantial suppression of RhB degradation, while OA significantly enhances the photocatalytic efficiency. Hydroxyl (•OH) radicals were examined by fluorimetry using terephthalic acid as a probe molecule, and are found to be produced over the simulated-sunlight irradiated LuFeO3 particles. The addition of ethanol leads to a quenching of •OH radicals, whereas the yield of •OH radicals is highly increased on addition of OA. Based on the experimental results, •OH radicals are suggested to be the dominant active species responsible for the dye degradation, while superoxide (•O2-) radicals play a negligible role in the photocatalysis.

  12. Interpretation of the high spin states in Lu161: A paired and unpaired study

    NASA Astrophysics Data System (ADS)

    Ma, Hai-Liang; Carlsson, B. Gillis; Ragnarsson, Ingemar; Ryde, Hans

    2014-07-01

    A paired cranked Nilsson-Strutinsky-Bogoliubov (CNSB) model is presented, which employs the same method to calculate the liquid-drop energy and moment of inertia as the unpaired cranked Nilsson-Strutinsky (CNS) model. In the CNSB model, the energy minimization is carried out in the mesh of pairing gaps Δ and Fermi levels λ as well as deformation parameters. The high spin states in Lu161 are then investigated with the CNSB and CNS models. The terminating structure shows a striking similarity with these two models. Combining the CNSB and CNS models, a complete understanding of high spin structures, including the normal deformed (ND) and triaxial strongly deformed (TSD) bands and observed side bands in Lu161, is achieved. It appears that the only important paired crossings are the first i13/2 neutron crossing and the first h11/2 proton crossing. For the description of the unpaired high spin crossings, it is important to be able to distinguish between the pseudospin partners in the proton N =4 shell, (d5/2,g7/2) and (d3/2,s1/2). The yrast bands are predicted to terminate, which explains the structure of a TSD-like band X2. A band crossing at I ≈36.5 for the TSD band in Lu161, unique within the chain of even-N Lu isotopes, is well described by the CNSB model.

  13. A New World: Redefining the Legacy of Min-Zhan Lu

    ERIC Educational Resources Information Center

    Ray, Brian

    2008-01-01

    This article discusses exchanges between a number of scholars during the 1990s centering on Min-Zhan Lu's controversial essay "Conflict and Struggle: The Enemies or Preconditions of Basic Writing?" In some ways, "Conflict and Struggle" blazed a trail for later work in "hybrid" or "mixed" forms of academic writing while at the same time igniting…

  14. Camptothecin Enhances Cell Death Induced by (177)Lu-EDTMP in Osteosarcoma Cells.

    PubMed

    Kumar, Chandan; Vats, Kusum; Lohar, Sharad P; Korde, Aruna; Samuel, Grace

    2014-10-01

    Lutetium-177 is an assured therapeutic radionuclide with favorable half-life and suitable β(-) energy. Radiolabeled (177)Lu-EDTMP (Ethylenediamine tetramethylene phosphonic acid) is by and large used for bone pain palliation in cancer patients. In vitro cell studies are carried out in osteosarcoma cells MG-63 to evaluate the combined effect of anticancer drug camptothecin (CPT) and (177)Lu-EDTMP. Two concentrations of (177)Lu-EDTMP (3.7 and 37 MBq) were incubated with MG63 cell line for 48 hours with and without pretreatment of CPT (10 nM) for 1 hour. After completion of incubation, the cells were harvested and cellular toxicity was estimated by LDH, MTT, and trypan blue dye. Apoptotic DNA fragmentation was estimated by ELISA kit. The expression of proteins such as bcl2, PARP, and MAPK (mitogen-activated protein kinase) that were related to apoptotic signaling pathways was assessed by western blotting. The results indicated that cellular toxicity and apoptosis were relatively higher in MG63 cells that were treated with CPT prior to treating with (177)Lu-EDTMP in comparison with the corresponding individual controls.

  15. Near-infrared Downconversion in LuPO4: Tm3+, Yb3+ Phosphors.

    PubMed

    Li, Li; Wang, Yongjie; Shen, Jun; Chang, Wenxuan; Jin, Tianting; Wei, Xiantao; Tian, Ya

    2016-04-01

    Tm3+ and Yb3+ codoped LuPO4 phosphors were synthesized by the reverse-strike co-precipitation method. The obtained LuPO4:Tm3+,Yb3+ phosphors were characterized by X-ray diffraction (XRD), diffuse reflectance spectra, photoluminescence (PL) spectra, and decay lifetime to understand the observed near-infrared downconversion (DC) phenomena. The XRD results show that all the prepared phosphors can be readily indexed to the pure tetragonal phase of LuPO4 and exhibit good crystallinity. The experimental results showed that the strong visible emission around 649 nm from Tm3+(1G4 --> 3F4) and near-infrared (NIR) emission around 1003 nm from Yb3+(2F5/2 --> 2F7/2) of LuPO4:Tm3+,Yb3+ phosphors were observed under 468 nm excitation, respectively. The Yb3+ concentration dependence of luminescent properties and lifetimes of both the visible and NIR emissions have also been investigated. The quenching concentration of Yb3+ ions approaches 30 mol%. The DC mechanism is also discussed in detail.

  16. Disorder-sensitive superconductivity in the doped iron silicide superconductor (Lu1-xRx)2Fe3Si5 ( R=Sc , Y, and Dy)

    NASA Astrophysics Data System (ADS)

    Watanabe, Tadataka; Sasame, Hiroki; Okuyama, Hiroaki; Takase, Kouichi; Takano, Yoshiki

    2009-09-01

    We studied the effect of nonmagnetic and magnetic impurities on superconductivity in Lu2Fe3Si5 by small-amount substitution of the Lu site and investigated structural, magnetic, and electrical properties of nonmagnetic (Lu1-xScx)2Fe3Si5 , (Lu1-xYx)2Fe3Si5 , and magnetic (Lu1-xDyx)2Fe3Si5 . The rapid depression of Tc by nonmagnetic impurities in accordance with the increase in the residual resistivity reveals the strong pair breaking dominated by disorder.

  17. Luminescent LuVO4:Ln3+ (Ln = Eu, Sm, Dy, Er) hollow porous spheres for encapsulation of biomolecules

    NASA Astrophysics Data System (ADS)

    Li, Dan; Liu, Chunlei; Jiang, Lianzhou

    2015-10-01

    In this study, LuVO4:Ln3+ (Ln = Eu, Sm, Dy, Er) hollow porous spheres, synthesized via self-sacrificing templated route, are developed for enzyme immobilization and protein adsorption. The four LuVO4 hollow spheres with diameter of 180 nm, 280 nm, 370 nm and 480 nm were obtained. The size of LuVO4 hollow sphere is dependent on Lu(OH)CO3 template. Upon excitation by UV light, hollow LuVO4:Ln3+ (Ln = Eu, Sm, Dy, Er) spheres exhibit red (Eu3+), orange (Sm3+), yellow-green (Dy3+), and green (Er3+) emissions. The good biocompatibility of sample is validated by MTT assay. Due to structure feature and size of obtained sample, the rapid encapsulation of biomolecules within samples has been achieved. Furthermore, the hollow spheres show different biomolecules adsorption capacities at different buffer solution pH values. The release behaviors of two kinds of biomolecules (lysozyme and bovine serum albumin) are also investigated. LuVO4 hollow spheres are suitable carriers for biomolecules. The emission intensity of Eu3+ in the LuVO4:Eu3+ varies with the released amount of LYZ. This enables the monitoring of release process by the change in the luminescence intensity.

  18. Influence of Eu(3+) doping content on antioxidant properties of Lu2O3 sol-gel derived nanoparticles.

    PubMed

    Olvera Salazar, Arturo; García Hernández, Margarita; López Camacho, Perla Yolanda; López Marure, Arturo; Reyes de la Torre, Adriana Isabel; Morales Ramírez, Ángel de Jesús; Hernández Santiago, Felipe; Aguilera Vázquez, Luciano

    2016-12-01

    This paper presents the synthesis of pure and europium-doped lutetium oxide (Lu2O3) powders prepared by sol-gel method. The influence of europium ion concentration into Lu2O3 nanocrystallites was investigated for first time in an in vitro system using a modified ABTS radical cation decolorization assay to determine the antioxidant activity. The crystalline structure of Lu2O3 and Eu:Lu2O3 powders was elucidated by XRD obtaining cubic phase in all system without secondary products in accordance with FT-IR results. By TEM and Scherrer equation, it was determined that Lu2O3 and Eu:Lu2O3 powders presented nearly spherical particle morphology with crystallites sizes in the range of 8 to 13nm. The antioxidant assays results revealed that europium ion enhance Lu2O3 powders antioxidant properties, showing that 12.5mol% of europium is sufficient to reach its maximum capacity. PMID:27612779

  19. Photodynamic therapy trials with lutetium texaphyrin (Lu-Tex) in patients with locally recurrent breast cancer

    NASA Astrophysics Data System (ADS)

    Renschler, Markus F.; Yuen, Alan R.; Panella, Timothy J.; Wieman, Thomas J.; Dougherty, Shona; Esserman, Laura; Panjehpour, Masoud; Taber, Scott W.; Fingar, Victor H.; Lowe, Elizabeth; Engel, Julie S.; Lum, Bert; Woodburn, Kathryn W.; Cheong, Wai-Fung; Miller, Richard A.

    1998-05-01

    Photodynamic therapy (PDT) of locally recurrent breast cancer has been limited to treatment of small lesions because of non- selective necrosis of adjacent normal tissues in the treatment field. Lutetium Texaphyrin (PCI-0123, Lu-Tex) is a photosensitizer with improved tumor localization that is activated by 732 nm light, which can penetrate through larger tumors. We have evaluated Lu-Tex in a Phase I trial and in an ongoing Phase II trial in women with locally recurrent breast cancer with large tumors who have failed radiation therapy. Patients received Lu-Tex intravenously by rapid infusion 3 hours before illumination of cutaneous or subcutaneous lesions. In Phase I, Lu-Tex doses were escalated from 0.6 to 7.2 mg/kg in 7 cohorts. Sixteen patients with locally recurrent breast cancer lesions were treated. Dose limiting toxicities above 5.5 mg/kg were pain in the treatment field during therapy, and dysesthesias in light exposed areas. No necrosis of normal tissues in the treated field was noticed. Responses were observed in 60% of evaluable patients [n equals 15, 27% complete remission (CR), 33% partial remission (PR)], with 63% of lesions responding (n equals 73: 45% CR, 18% PR). In Phase II, 25 patients have been studied to date, receiving two treatments ranging from 1.0 to 3.0 mg/kg at a 21 day interval. Treatment fields up to 480 cm2 in size were treated successfully and activity has been observed. Patients have experienced pain at the treatment site but no tissue necrosis. These studies demonstrate the feasibility of Lu-Tex PDT to large chest wall areas in women who have failed radiation therapy for the treatment of locally recurrent breast cancer. Treatment conditions are currently being optimized in the ongoing Phase II trials.

  20. Structural, microstructural and vibrational analyses of the monoclinic tungstate BiLuWO{sub 6}

    SciTech Connect

    Ait Ahsaine, H.; Taoufyq, A.; Patout, L.; Ezahri, M.; Benlhachemi, A.; Bakiz, B.; Villain, S.; Guinneton, F.; Gavarri, J.-R.

    2014-10-15

    The bismuth lutetium tungstate phase BiLuWO{sub 6} has been prepared using a solid state route with stoichiometric mixtures of oxide precursors. The obtained polycrystalline phase has been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Raman spectroscopy. In the first step, the crystal structure has been refined using Rietveld method: the crystal cell was resolved using monoclinic system (parameters a, b, c, β) with space group A2/m. SEM images showed the presence of large crystallites with a constant local nominal composition (BiLuW). TEM analyses showed that the actual local structure could be better represented by a superlattice (a, 2b, c, β) associated with space groups P2 or P2/m. The Raman spectroscopy showed the presence of vibrational bands similar to those observed in the compounds BiREWO{sub 6} with RE=Y, Gd, Nd. However, these vibrational bands were characterized by large full width at half maximum, probably resulting from the long range Bi/Lu disorder and local WO{sub 6} octahedron distortions in the structure. - Graphical abstract: The average structure of BiLuWO{sub 6} determined from X-ray diffraction data can be represented by A2/m space group. Experimental Electron Diffraction patterns along the [0vw] zone axes of the monoclinic structure and associated simulated patterns show the existence of a monoclinic superstructure with space group P2 or P2/m. - Highlights: • A new monoclinic BiLuWO{sub 6} phase has been elaborated from solid-state reaction. • The space group of the monoclinic disordered average structure should be A2/m. • Transmission electron microscopy leads to a superlattice with P2/m space group. • Raman spectroscopy suggests existence of local disorder.

  1. Comparison of structural and electrical properties of Lu{sub 2}O{sub 3} and Lu{sub 2}TiO{sub 5} gate dielectrics for α-InGaZnO thin-film transistors

    SciTech Connect

    Pan, Tung-Ming Chen, Ching-Hung; Her, Jim-Long; Koyama, Keiichi

    2014-11-21

    We compared the structural properties and electrical characteristics of high-κ Lu{sub 2}O{sub 3} and Lu{sub 2}TiO{sub 5} gate dielectrics for amorphous indium-gallium-zinc oxide (α-InGaZnO) thin-film transistor (TFT) applications. The Lu{sub 2}O{sub 3} film has a strong Lu{sub 2}O{sub 3} (400) peak in the X-ray diffraction pattern, while the Lu{sub 2}TiO{sub 5} sample shows a relatively weak Lu{sub 2}TiO{sub 5} (102) peak. Atomic force microscopy reveals that the Lu{sub 2}O{sub 3} dielectric exhibits a rougher surface (about three times) than Lu{sub 2}TiO{sub 5} one. In X-ray photoelectron spectroscopy analysis, we found that the intensity of the O 1s peak corresponding to Lu(OH){sub x} for Lu{sub 2}O{sub 3} film was higher than that of Lu{sub 2}TiO{sub 5} film. Furthermore, compared with the Lu{sub 2}O{sub 3} dielectric, the α-InGaZnO TFT using the Lu{sub 2}TiO{sub 5} gate dielectric exhibited a lower threshold voltage (from 0.43 to 0.25 V), a higher I{sub on}/I{sub off} current ratio (from 3.5 × 10{sup 6} to 1.3 × 10{sup 8}), a smaller subthreshold swing (from 276 to 130 mV/decade), and a larger field-effect mobility (from 14.5 to 24.4 cm{sup 2}/V s). These results are probably due to the incorporation of TiO{sub x} into the Lu{sub 2}O{sub 3} film to form a Lu{sub 2}TiO{sub 5} structure featuring a smooth surface, a low moisture absorption, a high dielectric constant, and a low interface state density at the oxide/channel interface. Furthermore, the stability of Lu{sub 2}O{sub 3} and Lu{sub 2}TiO{sub 5} α-InGaZnO TFTs was investigated under positive gate-bias stress (PGBS) and negative gate-bias stress (NGBS). The threshold voltage of the TFT performed under NGBS is more degradation than that under PGBS. This behavior may be attributed to the electron charge trapping at the dielectric–channel interface under PGBS, whereas the oxygen vacancies occurred in the InGaZnO under NGBS.

  2. Tuning of structure and enhancement of upconversion luminescence in NaLuF4:Yb(3+),Ho(3+) crystals.

    PubMed

    Lin, Hao; Xu, Dekang; Li, Anming; Teng, Dongdong; Yang, Shenghong; Zhang, Yueli

    2015-07-15

    A series of NaLuF4:Yb(3+),Ho(3+) nano/micro-crystals with different crystal structures were synthesized via a hydrothermal method using citric acid as a chelating agent. The influences of NaF content, Li(+) doping, reaction temperature and reaction time on the crystal structure and shape of the as-synthesized NaLuF4 crystals were systematically investigated. To the best of our knowledge, it is the first time to report Li(+) doped α-NaLuF4:Yb(3+),Ho(3+) nanocrystals and the phase transformation by introducing Li(+) in NaLuF4 crystals. As for Li(+) doped α-NaLuF4, UC luminescence intensities of green emission (538 nm) and red emission (644 nm) in α-NaLuF4:Yb(3+),Ho(3+) nanocrystals with 20 mol% Li(+) doping are enhanced by 20 and 3.5 times compared to their Li(+)-free counterpart. As for Li(+) doped α/β-mixed NaLuF4, with the increase of Li(+) content, the phase transforms from the α/β-mixed phase to hexagonal then to cubic. UC emissions of 538 nm and 644 nm in NaLuF4:Yb(3+),Ho(3+) crystals doped with 5 mol% Li(+) are enhanced by 26.5 and 23 times, respectively. Besides, it is found that with the higher temperature and prolonged time, the morphology of NaLuF4 changes from nanoparticles to microtubes, resulting in the dramatic increase of UC emission intensity. The effects of Li(+) doping, reaction temperature and reaction time on the enhancement of UC emission intensity are discussed in detail. This study provides an effective and facile approach to obtain nano/micro-crystals with controllable structures and excellent optical properties.

  3. Tuning of structure and enhancement of upconversion luminescence in NaLuF4:Yb(3+),Ho(3+) crystals.

    PubMed

    Lin, Hao; Xu, Dekang; Li, Anming; Teng, Dongdong; Yang, Shenghong; Zhang, Yueli

    2015-07-15

    A series of NaLuF4:Yb(3+),Ho(3+) nano/micro-crystals with different crystal structures were synthesized via a hydrothermal method using citric acid as a chelating agent. The influences of NaF content, Li(+) doping, reaction temperature and reaction time on the crystal structure and shape of the as-synthesized NaLuF4 crystals were systematically investigated. To the best of our knowledge, it is the first time to report Li(+) doped α-NaLuF4:Yb(3+),Ho(3+) nanocrystals and the phase transformation by introducing Li(+) in NaLuF4 crystals. As for Li(+) doped α-NaLuF4, UC luminescence intensities of green emission (538 nm) and red emission (644 nm) in α-NaLuF4:Yb(3+),Ho(3+) nanocrystals with 20 mol% Li(+) doping are enhanced by 20 and 3.5 times compared to their Li(+)-free counterpart. As for Li(+) doped α/β-mixed NaLuF4, with the increase of Li(+) content, the phase transforms from the α/β-mixed phase to hexagonal then to cubic. UC emissions of 538 nm and 644 nm in NaLuF4:Yb(3+),Ho(3+) crystals doped with 5 mol% Li(+) are enhanced by 26.5 and 23 times, respectively. Besides, it is found that with the higher temperature and prolonged time, the morphology of NaLuF4 changes from nanoparticles to microtubes, resulting in the dramatic increase of UC emission intensity. The effects of Li(+) doping, reaction temperature and reaction time on the enhancement of UC emission intensity are discussed in detail. This study provides an effective and facile approach to obtain nano/micro-crystals with controllable structures and excellent optical properties. PMID:26144530

  4. Reducing renal uptake of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues

    SciTech Connect

    Miao, Yubin; Fisher, Darrell R.; Quinn, Thomas P.

    2006-06-15

    The purpose of this study was to improve the tumor-to-kidney uptake ratios of 90Y- and 177Lu-[1,2,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-Re-Cys,D-Phe,Arg]alpha-melanocyte stimulating hormone (DOTA-RE(Arg)CCMSH), through coupling a negatively charged glutamic acid (Glu) to the peptide sequence. A new peptide of DOTA-Re(Glu,Arg)CCMSH was designed, synthesized and labeled with 90Y and 177Lu. Pharmacokinetics of 90Y- and 177Lu-DOTA-RE(Glu,Arg)CCNSH were determined in B16/F1 murine melanoma-bearing C57 mice. Both exhibited significantly less renal uptake than 90Y- and 177Lu-DOTA-Re(Arg)CCMSH at 30 min and at 2, 3, and 24 h after dose administration. The renal uptake values of 90Y- and 177Lu-DOTA-Re(Glu,Arg)CCMSH were 28.16% and 28.81% of those of 90Y- and 177Lu-DOTA-RE(Arg)CCMSH, respectively, at 4 hr post-injection. We also showed higher tumor-to-kidney uptake ratios 2.28 and 1.69 times that of 90Y- and 177Lu-DOTA-Re(Arg)CCMSH, respectively, at 4 h post-injection. The90Y- and 177Lu-DOTA-Re(Glu,Arg)CCMSH activity accumulation was low in normal organs except for kidneys. Coupling a negatively charged amino acid (Glu) to the CCMSH peptide sequence dramatically reduced the renal uptake values and increased the tumor-to-kidney uptake ratios of 90Y- and 177Lu-DOTA-Re(Glu,Arg)CCMSH, facilitating their potential applications as radiopharmaceuticals for targeted radionuclide therapy of melanoma.

  5. Positive Influence of 177Lu PSMA-617 Therapy on Bone Marrow Depression Caused by Metastatic Prostate Cancer.

    PubMed

    Schlenkhoff, Carl Diedrich; Gaertner, Florian; Essler, Markus; Schmidt, Matthias; Ahmadzadehfar, Hojjat

    2016-06-01

    A 75-year-old man with castrate-resistant prostate cancer and increasing prostate-specific antigen (PSA) level developed severe bone marrow depression during Ra radionuclide therapy. Because of this, he was treated with Lu-PSMA in compassionate use for this not-yet-approved therapy. At the beginning of Lu-PSMA therapy, repeated blood transfusions (BT) were necessary. Six months after the last BT, after 3 cycles of Lu-PSMA, his blood count stabilized. He required no further BTs and his PSA level remained lowered. PMID:26909716

  6. Composition and local bonding in RE-Si-M-O-N (M = Mg, Al ; RE = La, Lu) glasses

    SciTech Connect

    Fouquet, V; Paumier, F; Guittet, M; Gautier-Soyer, M; Satet, R. L.; Hoffmann, M. J.; Becher, Paul F; Painter, Gayle S

    2008-05-01

    Two series of oxynitride glasses, RE-Si-Mg-O-N (M = Mg, Al ; RE = La, Lu), have been studied by X-Ray photoelectron spectroscopy (XPS). The oxygen 1s photoelectron lineshape reveals a striking di erence depending on the rare earth, both in the Mg series and in the Al series. Actually, the oxygen 1s photoelectron lines of the La doped glasses are broader than the ones of the Lu doped glasses. This result is an experimental evidence that Lu has a larger a nity for oxygen versus nitrogen than La, as theoretically predicted by the ab initio calculations by Painter et al.

  7. The Lu-Hf isotopic composition of CHUR and BSE: Tighter constraints from unequilibrated chondrites

    NASA Astrophysics Data System (ADS)

    Bouvier, A.; Vervoort, J. D.; Patchett, J.

    2007-12-01

    The Lu-Hf isotopic system has been used increasingly in geochemistry as a chronometer and tracer of mantle and crust processes since the development of MC-ICPMS techniques [1]. Although a consensus has emerged on the value of the 176Lu decay constant, in contrast, the Lu and Hf isotopic compositions of the Chondrite Uniform Reservoir (CHUR) and Bulk Silicate Earth (BSE) have not been as well constrained. Lu-Hf isotopic compositions vary dramatically between the chondrite classes and petrologic types of the specimens that have been analyzed [1-3], which hampers a choice of Lu-Hf CHUR parameters. Chondrites are classified in three main petrologic groups: carbonaceous (CC), ordinary (OC) and enstatite chondrites (EC). They represent distinct chemical and isotopic compositions, which can be associated with reservoirs in the protoplanetary disk where the respective parent bodies have formed. They also have been subjected to various degrees of aqueous alteration (types 1 and 2) or thermal metamorphism (types 3-6) that has potentially affected their initial chemical and mineralogical characteristics. Despite the fact that numerous OCs (~50) have been analyzed for their Lu-Hf isotopic composition, nearly all of these have been equilibrated types 4-6; only 5 finds of types 3.6-3.8 unequilibrated OC have been analyzed. We have analyzed 20 new chondrites for Lu-Hf and Sm-Nd isotope systematics including (i) 13 H, L, and LL OC of types 3.0- 3.8, where their low degree of metamorphism limits the growth of phosphate (main carrier of REE) compared to the equilibrated OC; and (ii) 7 CC of types 1-3 (CI, CV, CO and CK groups). We obtained mean values (2σSE) of 176Lu/177Hf = 0.0337 ± 3, 176Hf/177Hf = 0.282802 ± 23, 147Sm/144Nd = 0.1961 ± 6, and 143Nd/144Nd = 0.512629 ± 16 from the types 1-3 OC and CC from this study and [2]. Our Lu-Hf values are higher than the previous estimates of [3] and are our best estimates for CHUR. The CC alone give higher mean values of 176Lu/177Hf

  8. 1.88 Micrometers InGaAsP Pumped, Room Temperature Ho: LuAG Laser

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.; Amzajerdian, Farzin; Reichle, Donald J.; Busch, George; Leisher, Paul

    2009-01-01

    A room temperature, directly diode pumped Ho:LuAG laser oscillated for the first time. Direct pumping of the Ho upper laser manifold maximizes efficiency, minimizes heating, and eliminates Ho:Tm energy sharing. Design and performance are presented.

  9. [177Lu-PSMA-617 therapy, dosimetry and follow-up in patients with metastatic castration-resistant prostate cancer].

    PubMed

    Fendler, Wolfgang P; Kratochwil, Clemens; Ahmadzadehfar, Hojjat; Rahbar, Kambiz; Baum, Richard P; Schmidt, Matthias; Pfestroff, Andreas; Lützen, Ulf; Prasad, Vikas; Heinzel, Alexander; Heuschkel, Martin; Ruf, Juri; Bartenstein, Peter; Krause, Bernd J

    2016-06-28

    Radioligand therapy (RLT) using 177Lu labelled inhibitors of the prostate-specific membrane antigen (177Lu-PSMA) is performed in patients with metastatic castration-resistant prostate cancer (mCRPC) after exhaustion of other options. German University Clinics offer RLT since 2013 on a compassionate use basis. The present consensus document includes recommendations for RLT with 177Lu-PSMA-617. These consensus statements were developed by an expert panel formed by the German Society of Nuclear Medicine (DGN) in December 2015. Statements include recommendations for indication, baseline tests, therapy protocol, concomitant therapy, dosimetry, and follow-up. Consensus recommendations aim to inform the attending medical staff, standardize 177Lu-PSMA-617 RLT, and improve quality of individual patient care. PMID:27350005

  10. Stability and Biodistribution of Thiol-Functionalized and (177)Lu-Labeled Metal Chelating Polymers Bound to Gold Nanoparticles.

    PubMed

    Yook, Simmyung; Lu, Yijie; Jeong, Jenny Jooyoung; Cai, Zhongli; Tong, Lemuel; Alwarda, Ramina; Pignol, Jean-Philippe; Winnik, Mitchell A; Reilly, Raymond M

    2016-04-11

    We are studying a novel radiation nanomedicine approach to treatment of breast cancer using 30 nm gold nanoparticles (AuNP) modified with polyethylene glycol (PEG) metal-chelating polymers (MCP) that incorporate 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelators for complexing the β-particle emitter, (177)Lu. Our objective was to compare the stability of AuNP conjugated to MCP via a single thiol [DOTA-PEG-ortho-pyridyl disulfide (OPSS)], a dithiol [DOTA-PEG-lipoic acid (LA)] or multithiol end-group [PEG-pGlu(DOTA)8-LA4] and determine the elimination and biodistribution of these (177)Lu-labeled MCP-AuNP in mice. Stability to aggregation in the presence of thiol-containing dithiothreitol (DTT), L-cysteine or glutathione was assessed and dissociation of (177)Lu-MCP from AuNP in human plasma measured. Elimination of radioactivity from the body of athymic mice and excretion into the urine and feces was measured up to 168 h post-intravenous (i.v.) injection of (177)Lu-MCP-AuNP and normal tissue uptake was determined. ICP-AES was used to quantify Au in the liver and spleen and these were compared to (177)Lu. Our results showed that PEG-pGlu(DOTA)8-LA4-AuNP were more stable to aggregation in vitro than DOTA-PEG-LA-AuNP and both forms of AuNP were more stable to thiol challenge than DOTA-PEG-OPSS-AuNP. PEG-pGlu((177)Lu-DOTA)8-LA4 was the most stable in plasma. Whole body elimination of (177)Lu was most rapid for mice injected with (177)Lu-DOTA-PEG-OPSS-AuNP. Urinary excretion accounted for >90% of eliminated (177)Lu. All (177)Lu-MCP-AuNP accumulated in the liver and spleen. Liver uptake was lowest for PEG-pGlu((177)Lu-DOTA)8-LA4-AuNP but these AuNP exhibited the greatest spleen uptake. There were differences in Au and (177)Lu in the liver for PEG-pGlu((177)Lu-DOTA)8-LA4-AuNP. These differences were not correlated with in vitro stability of the (177)Lu-MCP-AuNP. We conclude that conjugation of AuNP with PEG-pGlu((177)Lu-DOTA)8-LA4 via a multithiol

  11. L'hémangiopéricytome méningé: une tumeur intracrânienne rare - à propos d'un cas

    PubMed Central

    Errachdi, Amal; Asabbane, Amal; Epala, Brice Nkoua; Hemmich, Mariem; Kabbali, Naoual; Diakité, Adama; Kebdani, Tayeb; Benjaafar, Noureddine

    2014-01-01

    L'hémangiopéricytomeméningé intracrânien est une tumeur rare qui représente moins de 1% des tumeurs cérébrales. Son aspect radiologique peut être trompeur et faire porter à tort le diagnostic de méningiome. Le diagnostic de confirmation est histologique. Le traitement repose sur la chirurgie et la radiothérapie. L’évolution après traitement est caractérisée par la fréquence des récidives et des métastases à distance, imposant un suivi prolongé. Nous rapportons l'observation d'un patient présentant un hémangiopéricytome intracrânien dont l’évolution était marquée par l'absence de récidive à 4 ans de suivi. PMID:25170367

  12. Screening and identification of multi-components in Re Du Ning injections using LC/TOF-MS coupled with UV-irradiation.

    PubMed

    Li, Lingzhi; Wang, Zhenzhong; Peng, Ying; Fu, Xiaohuan; Wang, Yongxiang; Xiao, Wei; Song, Shaojiang

    2015-01-01

    A high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry-UV-irradiation (HPLC-QTOF-MS-UV) method was established for rapid separation and structural identification of the constituents in Re Du Ning Injections (RDNI). A total of 20 potentially bioactive compounds including 10 caffeoylquinic acids and 10 iridoid glycosides were identified or tentatively characterized in RDNI by comparing their retention times and MS spectra with those of authentic standards or literature data. In particular, UV-irradiation was employed in the identification of the cis/trans isomers of caffeoylquinic acids. Furthermore, each compound was assigned to the individual raw materials (Artemisia annua L., Lonicera japonica Thunb. or Gardenia jasminoides Ellis) present in RDNI. This is the first time that an HPLC-QTOF-MS-UV analytical method has been used for the identification of caffeoylquinic acids in RDNI. PMID:25265866

  13. Internal radiotherapy and dosimetric study for 111In/ 177Lu-pegylated liposomes conjugates in tumor-bearing mice

    NASA Astrophysics Data System (ADS)

    Wang, Hsin-Ell; Yu, Hung-Man; Lu, Yi-Ching; Heish, Ning-Ning; Tseng, Yun-Long; Huang, Kuang-Liang; Chuang, Kuo-Tang; Chen, Chin-Hsiung; Hwang, Jeng-Jong; Lin, Wuu-Jyh; Wang, Shyh-Jen; Ting, Gann; Whang-Peng, Jacqueline; Deng, Win-Ping

    2006-12-01

    In vivo characterization and dosimetric analysis has been performed to evaluate the potential of pegylated liposomes as carriers of radionuclides in tumor internal radiotherapy. MethodsThe DTPA/PEG-liposomes were synthesized with a medium size of 110 nm, conjugated with 111In/ 177Lu-(oxine) 3 to afford 111In/ 177Lu-liposome. The stability of 111In/ 177Lu-liposome in serum was investigated. The biodistribution, scintigraphic imaging and pharmacokinetics of 111In/ 177Lu-liposomes after intravenous(i.v.) injection into C-26 tumor-bearing BALB/cByJ mice were studied. Radiation dose was estimated by MIRD-III program. ResultsThe incorporation efficiency of 111In/ 177Lu into liposomes was 95%. After incubation at 37 °C for 72 h in serum, more than 83% of radioactivity was still retained in the intact 111In/ 177Lu-liposomes. The biodistribution of 111In-liposomes showed that the radioactivity in the blood decreased from 23.14±8.16%ID/g at 1 h to 0.02±0.00%ID/g at 72 h post-injection (p.i.), while reaching its maximum accumulation in tumors at 48 h p.i., with half-life in blood of 10.2 h. The results were supported by that of 177Lu-liposomes. Scintigraphic imaging with 111In-liposomes showed unambiguous tumor images at 48 h p.i. Dose estimation showed that the absorbed dose in tumor from 177Lu-liposomes was 5.74×10 -5 Gy/MBq. ConclusionsThis study provides an in vivo characterization and dosimetric evaluation for the use of liposome systems as carriers in targeted radionuclide therapy. The results suggest that adequate tumor targeting as well as dose delivered to tumors could be achieved by the use of radionuclide targeted liposomes.

  14. Peculiarities of thermoelectric half-Heusler phase formation in Gd-Ni-Sb and Lu-Ni-Sb ternary systems

    NASA Astrophysics Data System (ADS)

    Romaka, V. V.; Romaka, L.; Horyn, A.; Rogl, P.; Stadnyk, Yu; Melnychenko, N.; Orlovskyy, M.; Krayovskyy, V.

    2016-07-01

    The phase equilibria in the Gd-Ni-Sb and Lu-Ni-Sb ternary systems were studied at 873 K by X-ray and metallographic analyses in the whole concentration range. The interaction of the elements in the Gd-Ni-Sb system results the formation of five ternary compounds at investigated temperature: Gd5Ni2Sb (Mo5SiB2-type), Gd5NiSb2 (Yb5Sb3-type), GdNiSb (MgAgAs-type), Gd3Ni6Sb5 (Y3Ni6Sb5-type), and GdNi0.72Sb2 (HfCuSi2-type). At investigated temperature the Lu-Ni-Sb system is characterized by formation of the LuNiSb (MgAgAs-type), Lu5Ni2Sb (Mo5SiB2-type), and Lu5Ni0.56Sb2.44 (Yb5Sb3-type) compounds. The disordering in the crystal structure of half-Heusler GdNiSb and LuNiSb was revealed by EPMA and studied by means of Rietveld refinement and DFT modeling. The performed electronic structure calculations are in good agreement with electrical transport property studies.

  15. Jahn-Teller versus quantum effects in the spin-orbital material LuVO3

    DOE PAGES

    Skoulatos, M.; Toth, S.; Roessli, B.; Enderle, M.; Habicht, K.; Sheptyakov, D.; Cervellino, A.; Freeman, P. G.; Reehuis, M.; Stunault, A.; et al

    2015-04-13

    In this article, we report on combined neutron and resonant x-ray scattering results, identifying the nature of the spin-orbital ground state and magnetic excitations in LuVO3 as driven by the orbital parameter. In particular, we distinguish between models based on orbital-Peierls dimerization, taken as a signature of quantum effects in orbitals, and Jahn-Teller distortions, in favor of the latter. In order to solve this long-standing puzzle, polarized neutron beams were employed as a prerequisite in order to solve details of the magnetic structure, which allowed quantitative intensity analysis of extended magnetic-excitation data sets. The results of this detailed study enabledmore » us to draw definite conclusions about the classical versus quantum behavior of orbitals in this system and to discard the previous claims about quantum effects dominating the orbital physics of LuVO3 and similar systems.« less

  16. Preparation and characterization of optical spectroscopy of Lu 2O 3:Eu nanocrystals

    NASA Astrophysics Data System (ADS)

    Xu, Mei; Zhang, Weiping; Dong, Ning; Jiang, Yin; Tao, Ye; Yin, Min

    2005-02-01

    Nanoscale Lu 2O 3:Eu powders were prepared by solution combustion synthesis. X-ray diffraction (XRD), high-resolution electronic microscope (HREM), Fourier transform infrared spectroscopy (FT-IR), excitation and emission spectra, as well as fluorescent decay curves were measured to characterize the structure and luminescent properties of the samples. The results show that the compound of composition Lu 2O 3 crystallizes in pure cubic structure. By changing the ratio of glycine to nitrate in the combustion process, the particle size varies from 40 nm to less than 5 nm. The emission and excitation spectra strongly depend on the particle size of the samples. Novel emission band, red-shift of charge transfer band (CTB) and shortening of lifetime were observed in nanoscale samples.

  17. Radioactivity measurements of 177Lu, 111In and 123I by different absolute methods.

    PubMed

    Rezende, E A; Correia, A R; Iwahara, A; da Silva, C J; Tauhata, L; Poledna, R; da Silva, R L; de Oliveira, E M; de Oliveira, A E

    2012-09-01

    The activities of (177)Lu, (111)In and (123)I solutions have been absolutely determined using three different measurement methods. (177)Lu solution was standardized using the 4πβ(PC)-γ(NaI) coincidence and 4πβ(LS)-γ(NaI) live-timed anticoincidence methods. For the (111)In and (123)I solutions, besides these two mentioned methods, the coincidence sum-peak method was also applied. The measured activities results using these different methods are consistent within the evaluated experimental uncertainties demonstrating the equivalence of these methods. As an additional contribution to nuclear data, the half-lives have been determined using a well type IG12 ionization chamber.

  18. First-principles study of electronic and elastic properties of LuAl3

    NASA Astrophysics Data System (ADS)

    Shukla, Pushplata; Shrivastava, Deepika; Sanyal, Sankar P.

    2016-05-01

    A systematic theoretical study of electronic structure of rare earth intermetallic LuAl3 has been carried out using full potential linearized augmented plane wave (FP-LAPW) method based on density functional theory (DFT) within the generalized gradient approximation(GGA) for exchange and correlation potential. The ground state properties such as lattice constant (ao), bulk modulus (B) and pressure derivative of bulk modulus (Bˈ) were evaluated. LuAl3 has the cubic AuCu3 type crystal structure. The electronic properties of this compound have been analyzed quantatively from band structure and DOS. It is clear from band structure that this compound is metallic in nature. The calculated elastic constants infer that this compound is mechanically stable.

  19. Transculturation of Madness: The Double Origin of Lu Xun's "Diary of a Madman".

    PubMed

    Ma, Xiaolu

    2015-01-01

    Over the years scholars have examined the allegorical features of the depiction of madness in Lu Xun's "Diary of a Madman," yet to date little research has taken into consideration the intercultural angle embedded in the narrative's intersection of three cultures, namely Russian, Japanese and Chinese. This paper traces the European-Japanese-Sino route of modern neologisms of madness to explore the introduction of such neologisms into the modern Chinese language and how it corresponds with changing patterns of knowledge and power. I use my study of transculturation on the macro scale to frame a reexamination of the lexicon in "Diary of a Madman." I focus especially on kuangren and pohaikuang, the two key words employed by Lu Xun, to see how they contribute to the ambiguity in his attitude towards the power struggle between the East and the West, the old and the new. PMID:26949210

  20. Magnetic Hyperfine Fields in Lu_2 V_2 O_7 : A Model Approach

    NASA Astrophysics Data System (ADS)

    Agzamova, Polina; Nikiforov, Anatoliy; Nazipov, Dmitriy

    2016-02-01

    We report a theoretical approach to the investigation of the magnetic hyperfine interaction on the ^{51} V nucleus in Lu_2 V_2 O_7 with the view of understanding the orbital ordering pattern in this compound. First, we have evaluated the vanadium 3d^1 -level splitting (Δ ) under the crystal field with the D _{3d} -symmetry using the point charges approximation. Second, we have calculated the exchange interaction constant (J) using the ab initio approach. It is shown that the crystal field energy is much stronger than the exchange interaction one and hence the orbital liquid state cannot occur in Lu_2 V_2 O_7 . Finally we have analyzed the magnetic hyperfine field affecting the vanadium nucleus leaning upon these results.

  1. SuperLU{_}DIST: A scalable distributed-memory sparse direct solver for unsymmetric linear systems

    SciTech Connect

    Li, Xiaoye S.; Demmel, James W.

    2002-03-27

    In this paper, we present the main algorithmic features in the software package SuperLU{_}DIST, a distributed-memory sparse direct solver for large sets of linear equations. We give in detail our parallelization strategies, with focus on scalability issues, and demonstrate the parallel performance and scalability on current machines. The solver is based on sparse Gaussian elimination, with an innovative static pivoting strategy proposed earlier by the authors. The main advantage of static pivoting over classical partial pivoting is that it permits a priori determination of data structures and communication pattern for sparse Gaussian elimination, which makes it more scalable on distributed memory machines. Based on this a priori knowledge, we designed highly parallel and scalable algorithms for both LU decomposition and triangular solve and we show that they are suitable for large-scale distributed memory machines.

  2. Kinetic control of structural and magnetic states in LuBaCo4O7.

    SciTech Connect

    Avci, S.; Chmaissem, O.; Zheng, H.; Huq, A.; Khalyavin, D.; Stephens, P.; Suchomel, M.; Manuel, P.; Mitchell, J.

    2012-01-01

    The RBaCo{sub 4}O{sub 7} (R = Ca, Y, Tb, Ho, Tm, Yb, Lu) compounds provide a novel topology for studying the competition between triangular geometry and magnetic order. Here, we report the structural and magnetic behavior of the Lu member of this series via neutron and synchrotron x-ray diffraction, magnetization, and resistivity measurements. We determined sequential phase transitions and a strong competition between a stable and a metastable low-temperature state that critically depends on controlled cooling rates and the associated heat removal kinetics. No evidence for long-range ordered magnetism was detected by neutron diffraction at any temperature. However, very slow spin dynamics are evidenced by time-dependent neutron diffraction measurements and can be explained by several competing magnetic phases with incommensurate short-range correlations coexisting in this material.

  3. Direct evidence for inelastic neutron 'acceleration' by {sup 177}Lu{sup m}

    SciTech Connect

    Roig, O.; Meot, V.; Rosse, B.; Belier, G.; Daugas, J.-M.; Morel, P.; Letourneau, A.; Menelle, A.

    2011-06-15

    The inelastic neutron acceleration cross section on the long-lived metastable state of {sup 177}Lu has been measured using a direct method. High-energy neutrons have been detected using a specially designed setup placed on a cold neutron beam extracted from the ORPHEE reactor in Saclay. The 146{+-}19 b inelastic neutron acceleration cross section in the ORPHEE cold neutron flux confirms the high cross section for this process on the {sup 177}Lu{sup m} isomer. The deviation from the 258{+-}58 b previously published obtained for a Maxwellian neutron flux at a 323 K temperature could be explained by the presence of a low energy resonance. Resonance parameters are deduced and discussed.

  4. Spectroscopy and laser performance of Nd:Lu_2O_3 crystal

    NASA Astrophysics Data System (ADS)

    Hao, Liangzhen; Wu, Kui; Cong, Hengjiang; Yu, Haohai; Zhang, Huaijin; Wang, Zhengping; Wang, Jiyang

    2011-08-01

    The spectra of Nd3+:Lu2O3 crystal have been examined at room temperature. Judd-Ofelt theory was applied to calculate the spectral parameters of the crystal. With a laser diode as pump source, a continuous-wave laser output power of 2.81 W is achieved, which is the highest value ever reported in this crystals to our knowledge, and its wavelength is also found to be dual-wavelength. Because of the emission cross-section at 1076 nm and 1080 nm are almost identical, laser oscillation for such two wavelengths can be obtained simultaneously. All the properties show that Nd:Lu2O3 is an excellent crystal for laser applications.

  5. Radioactivity measurements of 177Lu, 111In and 123I by different absolute methods.

    PubMed

    Rezende, E A; Correia, A R; Iwahara, A; da Silva, C J; Tauhata, L; Poledna, R; da Silva, R L; de Oliveira, E M; de Oliveira, A E

    2012-09-01

    The activities of (177)Lu, (111)In and (123)I solutions have been absolutely determined using three different measurement methods. (177)Lu solution was standardized using the 4πβ(PC)-γ(NaI) coincidence and 4πβ(LS)-γ(NaI) live-timed anticoincidence methods. For the (111)In and (123)I solutions, besides these two mentioned methods, the coincidence sum-peak method was also applied. The measured activities results using these different methods are consistent within the evaluated experimental uncertainties demonstrating the equivalence of these methods. As an additional contribution to nuclear data, the half-lives have been determined using a well type IG12 ionization chamber. PMID:22401938

  6. Dynamic monitoring of vegetation coverage change in Lu County based on TM/OLI-NDVI

    NASA Astrophysics Data System (ADS)

    Zeng, Sen; Liu, Hanhu; Chen, Tao

    2014-11-01

    TM data of 1998, 2002 and OLI data of 2013 were chosen in Lu County. Fractional Vegetation Cover of study area was obtained based on the basic processing of data measurement ascertaining atmospheric correction, the retrieval of surface albedo and the calculation of Normalized Difference Vegetation Index (NDVI) in this research. Spatial differences and influencing factors of Fractional Vegetation Cover in Lu County over past twenty five years were obtained through statistical and analysis. Studies have shown that vegetation cover changed for the better in the 35.62 percent areas of Lu County from 1988 to 2002 and 15.54 percent areas changed for the worse. The main factor that vegetation cover changed for the better is the change of imaging time. Significant increase could be found in vegetation cover because rice was not harvested on August 5 in 2002, but the opposite of September 5 in 1988. Meanwhile, scattered residential building construction in the southeast, agricultural land and mall-scale urban construction in the southwest could be main factors that had made vegetation cover changed for the worse. From 2002 to 2013, vegetation cover changed for the better in the 12.29 percent areas where located in the southeast of Lu County mainly because regional vegetation change. Meanwhile, vegetation cover changed for the worse in the 39.28 percent areas mainly because a large number of urban construction and mining development area in the middle and west and a large number of new scattered residential and agricultural land in the west and east.

  7. Neutron capture measurement on 173Lu at LANSCE with DANCE detector

    NASA Astrophysics Data System (ADS)

    Theroine, C.; Ebran, A.; Méot, V.; Roig, O.; Bond, E. M.; Bredeweg, T. A.; Couture, A.; Haight, R. C.; Jandel, M.; Nortier, F. M.; O'Donnell, J. M.; Rundberg, R. S.; Taylor, W. A.; Ullmann, J. L.; Viera, D. J.; Wilhelmy, J. B.; Wouters, J. M.

    2013-06-01

    The (n,γ) cross section on the unstable 173Lu(t1/2 = 1.37y) has been measured from thermal energy up to 200 eV at Los Alamos Neutron Science Center (LANSCE) with The Detector for Advanced Neutron Capture Experiements (DANCE). The main aim of this study is to validate and optimize reaction models for unstable nucleus. A preliminary capture yield will be presented in this paper.

  8. Competing Ferri- and Antiferromagnetic Phases in Geometrically Frustrated LuFe2O4

    SciTech Connect

    De Groot, J.; Marty, Karol J; Lumsden, Mark D; Christianson, Andrew D; Nagler, Stephen E; Adiga, Shilpa; Borghols, Wouter; Schmalzl, Karin; Yamani, Z.; Bland, S. R.; de Souza, R.; Staub, U.; Schweika, Werner; Su, Y.; Angst, Manuel

    2012-01-01

    We present a detailed study of magnetism in LuFe2O4, combining magnetization measurements with neutron and soft x-ray diffraction. The magnetic phase diagram in the vicinity of TN involves a metamagnetic transition separating an antiferro- and a ferrimagnetic phase. For both phases the spin structure is refined by neutron diffraction. Observed diffuse magnetic scattering far above TN is explained in terms of near degeneracy of the magnetic phases.

  9. Heat capacity and thermal expansion of icosahedral lutetium boride LuB66

    SciTech Connect

    Novikov, V V; Avdashchenko, D V; Matovnikov, A V; Mitroshenkov, N V; Bud’ko, S L

    2014-01-07

    The experimental values of heat capacity and thermal expansion for lutetium boride LuB66 in the temperature range of 2-300 K were analysed in the Debye-Einstein approximation. It was found that the vibration of the boron sub-lattice can be considered within the Debye model with high characteristic temperatures; low-frequency vibration of weakly connected metal atoms is described by the Einstein model.

  10. Neutron capture measurement on {sup 173}Lu at LANSCE with DANCE detector

    SciTech Connect

    Theroine, C.; Ebran, A.; Meot, V.; Roig, O.; Bond, E. M.; Bredeweg, T. A.; Couture, A.; Haight, R. C.; Jandel, M.; Nortier, F. M.; O'Donnell, J. M.; Rundberg, R. S.; Taylor, W. A.; Ullmann, J. L.; Viera, D. J.; Wilhelmy, J. B.; Wouters, J. M.

    2013-06-10

    The (n,{gamma}) cross section on the unstable {sup 173}Lu(t{sub 1/2} = 1.37y) has been measured from thermal energy up to 200 eV at Los Alamos Neutron Science Center (LANSCE) with The Detector for Advanced Neutron Capture Experiements (DANCE). The main aim of this study is to validate and optimize reaction models for unstable nucleus. A preliminary capture yield will be presented in this paper.

  11. Implementation of BT, SP, LU, and FT of NAS Parallel Benchmarks in Java

    NASA Technical Reports Server (NTRS)

    Schultz, Matthew; Frumkin, Michael; Jin, Hao-Qiang; Yan, Jerry

    2000-01-01

    A number of Java features make it an attractive but a debatable choice for High Performance Computing. We have implemented benchmarks working on single structured grid BT,SP,LU and FT in Java. The performance and scalability of the Java code shows that a significant improvement in Java compiler technology and in Java thread implementation are necessary for Java to compete with Fortran in HPC applications.

  12. Morphology evolution and pure red upconversion mechanism of β-NaLuF4 crystals

    NASA Astrophysics Data System (ADS)

    Lin, Hao; Xu, Dekang; Li, Anming; Teng, Dongdong; Yang, Shenghong; Zhang, Yueli

    2016-06-01

    A series of β-NaLuF4 crystals were synthesized via a hydrothermal method. Hexagonal phase microdisks, microprisms, and microtubes were achieved by simply changing the amount of citric acid in the initial reaction solution. Pure red upconversion (UC) luminescence can be observed in β-NaLuF4:Yb3+, Tm3+, Er3+ and Li+ doped β-NaLuF4:20% Yb3+, 1% Tm3+, 20% Er3+. Based on the rate equations, we report the theoretical model about the pure red UC mechanism in Yb3+/Tm3+/Er3+ doped system. It is proposed that the pure red UC luminescence is mainly ascribed to the energy transfer UC from Tm3+:3F4 → 3H6 to Er3+:4I11/2 → 4F9/2 and the cross-relaxation (CR) effect [Er3+:4S3/2 + 4I15/2 → 4I9/2 + 4I13/2] rather than the long-accepted mechanism [CR process among Er3+:4F7/2 + 4I11/2 → 4F9/2 + 4F9/2]. In addition, compared to the Li+-free counterpart, the pure red UC luminescence in β-NaLuF4:20% Yb3+, 1% Tm3+, 20% Er3+ with 15 mol% Li+ doping is enhanced by 13.7 times. This study provides a general and effective approach to obtain intense pure red UC luminescence, which can be applied to other synthetic strategies.

  13. Morphology evolution and pure red upconversion mechanism of β-NaLuF4 crystals.

    PubMed

    Lin, Hao; Xu, Dekang; Li, Anming; Teng, Dongdong; Yang, Shenghong; Zhang, Yueli

    2016-01-01

    A series of β-NaLuF4 crystals were synthesized via a hydrothermal method. Hexagonal phase microdisks, microprisms, and microtubes were achieved by simply changing the amount of citric acid in the initial reaction solution. Pure red upconversion (UC) luminescence can be observed in β-NaLuF4:Yb(3+), Tm(3+), Er(3+) and Li(+) doped β-NaLuF4:20% Yb(3+), 1% Tm(3+), 20% Er(3+). Based on the rate equations, we report the theoretical model about the pure red UC mechanism in Yb(3+)/Tm(3+)/Er(3+) doped system. It is proposed that the pure red UC luminescence is mainly ascribed to the energy transfer UC from Tm(3+):(3)F4 → (3)H6 to Er(3+):(4)I11/2 → (4)F9/2 and the cross-relaxation (CR) effect [Er(3+):(4)S3/2 + (4)I15/2 → (4)I9/2 + (4)I13/2] rather than the long-accepted mechanism [CR process among Er(3+):(4)F7/2 + (4)I11/2 → (4)F9/2 + (4)F9/2]. In addition, compared to the Li(+)-free counterpart, the pure red UC luminescence in β-NaLuF4:20% Yb(3+), 1% Tm(3+), 20% Er(3+) with 15 mol% Li(+) doping is enhanced by 13.7 times. This study provides a general and effective approach to obtain intense pure red UC luminescence, which can be applied to other synthetic strategies. PMID:27306720

  14. Yb doping concentration and temperature influence on Yb:LuAG thermal lensing

    NASA Astrophysics Data System (ADS)

    Veselský, Karel; Šulc, Jan; Jelínková, Helena; Nejezchleb, Karel; Škoda, Václav

    2016-03-01

    The aim of this study was to investigate whether refractive power of thermal lens for Yb:LuAG crystal at cryogenic temperatures depends on Yb doping concentration which has not been examined yet. The three measured Yb:LuAG laser rods samples (length of 3 mm, diameter 3 mm, AR @ 0.94 μm and 1.03 μm, doping concentration 5.4, 8.4 and 16.6 at. % Yb/Lu) were mounted in the temperature controlled copper holder of the liquid nitrogen cryostat. Samples were longitudinally pumped with fiber coupled CW laser diode at 0.930 μm with the focal point 0.4 mm in diameter. The 38 mm long semi-hemispherical laser resonator consisted of a flat pump mirror (HR @ 1.03 μm and HT 0.94 μm) and curved output coupler (r=500 mm) of reflectivity 94 % @ 1.06 μm. The refractive power of thermal lens was estimated indirectly by measuring of change in the position of focused laser beam focal point. The measurement was performed for constant absorbed power of 10 W in temperature range from 80 up to 240 K. It was observed that cryogenic cooling caused reduction of thermal lens power, which increased linearly with increasing temperature. For temperatures from 80 to 160 K refractive power was identical for all concentration. For higher temperature the refractive power of thermal lens increased with increasing Yb3+ concentration. Presented study shows that application of cryogenic temperature leads to reduction of thermal effect even for high dopant concentration in Yb:LuAG crystal. This is essential for reaching of high output power while maintaining high beam quality.

  15. Morphology evolution and pure red upconversion mechanism of β-NaLuF4 crystals

    PubMed Central

    Lin, Hao; Xu, Dekang; Li, Anming; Teng, Dongdong; Yang, Shenghong; Zhang, Yueli

    2016-01-01

    A series of β-NaLuF4 crystals were synthesized via a hydrothermal method. Hexagonal phase microdisks, microprisms, and microtubes were achieved by simply changing the amount of citric acid in the initial reaction solution. Pure red upconversion (UC) luminescence can be observed in β-NaLuF4:Yb3+, Tm3+, Er3+ and Li+ doped β-NaLuF4:20% Yb3+, 1% Tm3+, 20% Er3+. Based on the rate equations, we report the theoretical model about the pure red UC mechanism in Yb3+/Tm3+/Er3+ doped system. It is proposed that the pure red UC luminescence is mainly ascribed to the energy transfer UC from Tm3+:3F4 → 3H6 to Er3+:4I11/2 → 4F9/2 and the cross-relaxation (CR) effect [Er3+:4S3/2 + 4I15/2 → 4I9/2 + 4I13/2] rather than the long-accepted mechanism [CR process among Er3+:4F7/2 + 4I11/2 → 4F9/2 + 4F9/2]. In addition, compared to the Li+-free counterpart, the pure red UC luminescence in β-NaLuF4:20% Yb3+, 1% Tm3+, 20% Er3+ with 15 mol% Li+ doping is enhanced by 13.7 times. This study provides a general and effective approach to obtain intense pure red UC luminescence, which can be applied to other synthetic strategies. PMID:27306720

  16. Test beam results of a high granularity LuAG fibre calorimeter prototype

    NASA Astrophysics Data System (ADS)

    Benaglia, A.; Lucchini, M.; Pauwels, K.; Tully, C.; Medvedeva, T.; Heering, A.; Dujardin, C.; Kononets, V.; Lebbou, K.; Aubry, N.; Faraj, S.; Ferro, G.; Lecoq, P.; Auffray, E.

    2016-05-01

    The progresses in the micropulling-down technique allow heavy scintillating crystals to be grown directly into a fibre geometry of variable shape, length and diameter. Examples of materials that can be grown with this technique are Lutetium Aluminum Garnets (LuAG, Lu3Al5O12) and Yttrium Aluminum Garnets (YAG, Y3Al5O12). Thanks to the flexibility of this approach, combined with the high density and good radiation hardness of the materials, such a technology represents a powerful tool for the development of future calorimeters. As an important proof of concept of the application of crystal fibres in future experiments, a small calorimeter prototype was built and tested on beam. A grooved brass absorber (dimensions 26cm×7cm×16cm) was instrumented with 64 LuAG fibres, 56 of which were doped with Cerium, while the remaining 8 were undoped. Each fibre was readout individually using 8 eightfold Silicon Photomultiplier arrays, thus providing a highly granular description of the shower development inside the module as well as good tracking capabilities. The module was tested at the Fermilab Test Beam Facility using electrons and pions in the 2-16 GeV energy range. The module performance as well as fibre characterization results from this beam test are presented.

  17. Luminescence and scintillation properties of Lu3Al5O12 nanoceramics sintered by SPS method

    NASA Astrophysics Data System (ADS)

    Pejchal, Jan; Babin, Vladimir; Beitlerova, Alena; Kucerkova, Romana; Panek, Dalibor; Barta, Jan; Cuba, Vaclav; Yamaji, Akihiro; Kurosawa, Shunsuke; Mihokova, Eva; Ito, Akihiko; Goto, Takashi; Nikl, Martin; Yoshikawa, Akira

    2016-03-01

    Ce-doped lutetium aluminum garnet Lu3Al5O12 (LuAG) nanoceramics were fabricated at 1600 °C and 1700 °C by spark-plasma sintering (SPS) method from nano-powders prepared by radiation synthesis. Both undoped and Ce-doped LuAG ceramic samples were also prepared from the nano-powders at 1700 °C with significantly increased pre-heating rate. The backscattered electron images revealed large amount of pores in all the Ce-doped samples causing their significant opacity. On the other hand, very large grains and no pores were revealed in the undoped sample, which was the only transparent one. The radioluminescence measurements revealed superior overall scintillation efficiency of the samples sintered at the temperature 1700 °C, and their defect emission in the UV region was ascribed to oxygen-vacancy-related defects such as F+ centers. The photoluminescence decay of the defect emission was characterized by an extremely fast decay time of a few nanoseconds. Influence of sintering procedure and subsequent annealing on the luminescence and scintillation properties is discussed.

  18. (177)Lu-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics.

    PubMed

    Jing, Lijia; Shi, Jiyun; Fan, Di; Li, Yaqian; Liu, Renfa; Dai, Zhifei; Wang, Fan; Tian, Jie

    2015-10-01

    This Article reported the fabrication of a robust theranostic cerasome encapsulating indocyanine green (ICG) by incorporating 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)2000]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DSPE-PEG2000-DOTA), followed by chelating radioisotope of (177)Lu. Its applications in optical and nuclear imaging of tumor uptake and biodistribution, as well as photothermal killing of cancer cells, were investigated. It was found that the obtained cerasome could act efficiently as fluorescence contrast agent as well as nuclear imaging tracer. Encapsulating ICG into cerasome could protect ICG from degradation, aggregation, and fast elimination from body, resulting in remarkable improvement in near-infrared fluorescence imaging, photothermal stability, and in vivo pharmacokinetic profile. Both fluorescence and nuclear imaging showed that such agent could selectively accumulate in tumor site after intravenous injection of the cerasome agent into Lewis lung carcinoma tumor bearing mice, resulting in efficient photothermal ablation of tumor through a one-time NIR laser irradiation at the best time window. The ability to track the uptake of cerasomes on a whole body basis could provide researchers with an excellent tool for developing cerasome-based drug delivery agents, especially the strategy of labeling cerasomes with theranostic radionuclide (177)Lu, enabling the ability of the (177)Lu-labeled cerasomes for radionuclide cancer therapy and even the combined therapy.

  19. Lu-Hf total-rock age for the Amîtsoq gneisses, West Greenland

    USGS Publications Warehouse

    Pettingill, H.S.; Patchett, P.J.

    1981-01-01

    Lu-Hf total-rock data for the Amîtsoq gneisses of West Greenland yield an age of 3.55±0.22Gy(2σ), based on the decay constant λ176Lu=1.96×10−11y−1, and an initial176Hf/177Hf ratio of 0.280482±33. The result is in good agreement with Rb-Sr total-rock and U-Pb zircon ages. In spite of severe metamorphism of the area at 2.9 Gy, zircons from two of the samples have remained on the total-rock line, and define points close to the initial Hf ratio. The initial176Hf/177Hf lies close to a chondritic Hf isotopic evolution curve from 4.55 Gy to present. This is consistent with the igneous precursors to the Amîtsoq gneisses having been derived from the mantle at or shortly before 3.6 Gy. Anomalous relationships between Hf concentration and the176Lu/177Hf ratio may suggest that trace element abundances in the Amîtsoq gneisses are partly controlled by processes related to metamorphism.

  20. An In-Depth Analysis of the Chung-Lu Model

    SciTech Connect

    Winlaw, M.; DeSterck, H.; Sanders, G.

    2015-10-28

    In the classic Erd}os R enyi random graph model [5] each edge is chosen with uniform probability and the degree distribution is binomial, limiting the number of graphs that can be modeled using the Erd}os R enyi framework [10]. The Chung-Lu model [1, 2, 3] is an extension of the Erd}os R enyi model that allows for more general degree distributions. The probability of each edge is no longer uniform and is a function of a user-supplied degree sequence, which by design is the expected degree sequence of the model. This property makes it an easy model to work with theoretically and since the Chung-Lu model is a special case of a random graph model with a given degree sequence, many of its properties are well known and have been studied extensively [2, 3, 13, 8, 9]. It is also an attractive null model for many real-world networks, particularly those with power-law degree distributions and it is sometimes used as a benchmark for comparison with other graph generators despite some of its limitations [12, 11]. We know for example, that the average clustering coe cient is too low relative to most real world networks. As well, measures of a nity are also too low relative to most real-world networks of interest. However, despite these limitations or perhaps because of them, the Chung-Lu model provides a basis for comparing new graph models.

  1. Lu-Hf total-rock age for the Amitsoq gneisses, West Greenland

    NASA Technical Reports Server (NTRS)

    Pettingill, H. S.; Patchett, P. J.

    1981-01-01

    Lu-Hf total-rock data for the Amitsoq gneisses of West Greenland yield an age of 3.55 + or - 0.22 billion years, based on the decay constant for Lu-176 of 1.96 x 10 to the -11th/year, and an initial Hf-176/Hf-177 ratio of 0.280482 + or - 33. The result is in good agreement with Rb-Sr total-rock and U-Pb zircon ages. In spite of severe metamorphism of the area at 2.9 billion years, zircons from two of the samples have remained on the total-rock line, and define points close to the initial Hf ratio. The initial Hf-176/Hf-177 lies close to a chondritic Hf isotopic evolution curve from 4.55 billion years to present. This is consistent with the igneous precursors to the Amitsoq gneisses having been derived from the mantle at or shortly before 3.6 billion years. Anomalous relationships between Hf concentration and the Lu-176/Hf-177 ratio may suggest that trace element abundances in the Amitsoq gneisses are partly controlled by processes related to metamorphism.

  2. On the photoelectron velocity-map imaging of lutetium monoxide anion LuO{sup −}

    SciTech Connect

    Liu, Zhiling; Xie, Hua; Qin, Zhengbo; Cong, Ran; Wu, Xia; Tang, Zichao Fan, Hongjun; Li, Quanjiang

    2014-01-21

    We report a combined photoelectron velocity-map imaging spectroscopy and density functional theory investigation on lutetium monoxide anion. Transition between the X {sup 1}Σ{sup +} anion electronic ground state and the neutral X {sup 2}Σ{sup +} electronic ground state is observed. Vibrationally resolved spectra were obtained at four different photon energies, providing a wealth of spectroscopic information for the electronic ground states of the anionic lutetium monoxide and corresponding neutral species. Franck-Condon simulations of the ground-state transition are performed to assign vibrational structure in the spectra and to assist in identifying the observed spectral bands. The electronic ground state of LuO{sup −} is found to have a vibrational frequency of 743 ± 10 cm{sup −1} and an equilibrium bond length of 1.841 Å. The electron affinity of LuO is measured to be 1.624 ± 0.002 eV. The fundamental frequency of ground-state LuO is estimated to be 839 ± 10 cm{sup −1}.

  3. Test beam results of a high granularity LuAG fibre calorimeter prototype

    NASA Astrophysics Data System (ADS)

    Benaglia, A.; Lucchini, M.; Pauwels, K.; Tully, C.; Medvedeva, T.; Heering, A.; Dujardin, C.; Kononets, V.; Lebbou, K.; Aubry, N.; Faraj, S.; Ferro, G.; Lecoq, P.; Auffray, E.

    2016-05-01

    The progresses in the micropulling-down technique allow heavy scintillating crystals to be grown directly into a fibre geometry of variable shape, length and diameter. Examples of materials that can be grown with this technique are Lutetium Aluminum Garnets (LuAG, Lu3Al5O12) and Yttrium Aluminum Garnets (YAG, Y3Al5O12). Thanks to the flexibility of this approach, combined with the high density and good radiation hardness of the materials, such a technology represents a powerful tool for the development of future calorimeters. As an important proof of concept of the application of crystal fibres in future experiments, a small calorimeter prototype was built and tested on beam. A grooved brass absorber (dimensions 26cm×7cm×16cm) was instrumented with 64 LuAG fibres, 56 of which were doped with Cerium, while the remaining 8 were undoped. Each fibre was readout individually using 8 eightfold Silicon Photomultiplier arrays, thus providing a highly granular description of the shower development inside the module as well as good tracking capabilities. The module was tested at the Fermilab Test Beam Facility using electrons and pions in the 2–16 GeV energy range. The module performance as well as fibre characterization results from this beam test are presented.

  4. Normal and superdeformed high-spin structures in {sup 161}Lu

    SciTech Connect

    Bringel, P.; Huebel, H.; Al-Khatib, A.; Buerger, A.; Nenoff, N.; Neusser-Neffgen, A.; Schoenwasser, G.; Singh, A.K.; Hagemann, G.B.; Herskind, B.; Jensen, D.R.; Sletten, G.; Bednarczyk, P.; Curien, D.; Joss, D.T.; Simpson, J.; Gangopadhyay, G.; Kroell, Th.; Lo Bianco, G.; Petrache, C.M.

    2006-05-15

    High-spin states in {sup 161}Lu were populated in the {sup 139}La({sup 28}Si, 6n) reaction and {gamma}-ray coincidences were measured with the EUROBALL spectrometer. On the basis of these data, the previously known level scheme is extended with new band structures and is partly revised. Configuration assignments are made to all bands based on comparison of experimental properties with cranked shell model calculations. A strongly populated band with parity and signature ({pi},{alpha})=(+,-1/2) is found to be yrast above spin I{approx_equal}33. This band shows characteristics resembling those of two triaxial superdeformed bands in this nucleus based on the occupation of the shape-driving i{sub 13/2} proton orbital. This structure, unique to {sup 161}Lu within the chain of even-N Lu isotopes, is discussed in terms of a quasiparticle configuration in a local triaxial minimum with a larger triaxiality and a smaller quadrupole deformation than calculated for the i{sub 13/2} proton excitation.

  5. Atomic and electronic structures of lutetium oxide Lu{sub 2}O{sub 3}

    SciTech Connect

    Kaichev, V. V.; Asanova, T. I.; Erenburg, S. B.; Perevalov, T. V.; Shvets, V. A.; Gritsenko, V. A.

    2013-02-15

    The chemical composition, electronic structure, structure, and physical properties a lutetium oxide Lu{sub 2}O{sub 3} film are studied by X-ray photoelectron spectroscopy, ellipsometry, and X-ray absorption spectroscopy. The short-range order in Lu{sub 2}O{sub 3} is found to correspond to its cubic modification. The binding energies of the 1s and 2p levels of oxygen and the 4d{sub 5/2} and 4f{sub 7/2} levels of lutetium are 529.2, 5.0 and 7.4, 195.9 eV, respectively. The energy gap determined from the electron energy loss spectrum of the film is 5.9 eV. The electron energy loss spectra have two peaks at 17.4 and 22.0 eV, which can be attributed to the excitation of bulk plasma oscillations. The dispersion of the refractive index is measured by spectral ellipsometry. The refractive index is shown to increase from 1.82 at 1.5 eV to 2.18 at 5.0 eV, and the high-frequency permittivity of Lu{sub 2}O{sub 3} is 3.31.

  6. On the photoelectron velocity-map imaging of lutetium monoxide anion LuO(-).

    PubMed

    Liu, Zhiling; Xie, Hua; Li, Quanjiang; Qin, Zhengbo; Cong, Ran; Wu, Xia; Tang, Zichao; Fan, Hongjun

    2014-01-21

    We report a combined photoelectron velocity-map imaging spectroscopy and density functional theory investigation on lutetium monoxide anion. Transition between the X (1)Σ(+) anion electronic ground state and the neutral X (2)Σ(+) electronic ground state is observed. Vibrationally resolved spectra were obtained at four different photon energies, providing a wealth of spectroscopic information for the electronic ground states of the anionic lutetium monoxide and corresponding neutral species. Franck-Condon simulations of the ground-state transition are performed to assign vibrational structure in the spectra and to assist in identifying the observed spectral bands. The electronic ground state of LuO(-) is found to have a vibrational frequency of 743 ± 10 cm(-1) and an equilibrium bond length of 1.841 Å. The electron affinity of LuO is measured to be 1.624 ± 0.002 eV. The fundamental frequency of ground-state LuO is estimated to be 839 ± 10 cm(-1).

  7. (177)Lu-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics.

    PubMed

    Jing, Lijia; Shi, Jiyun; Fan, Di; Li, Yaqian; Liu, Renfa; Dai, Zhifei; Wang, Fan; Tian, Jie

    2015-10-01

    This Article reported the fabrication of a robust theranostic cerasome encapsulating indocyanine green (ICG) by incorporating 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)2000]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DSPE-PEG2000-DOTA), followed by chelating radioisotope of (177)Lu. Its applications in optical and nuclear imaging of tumor uptake and biodistribution, as well as photothermal killing of cancer cells, were investigated. It was found that the obtained cerasome could act efficiently as fluorescence contrast agent as well as nuclear imaging tracer. Encapsulating ICG into cerasome could protect ICG from degradation, aggregation, and fast elimination from body, resulting in remarkable improvement in near-infrared fluorescence imaging, photothermal stability, and in vivo pharmacokinetic profile. Both fluorescence and nuclear imaging showed that such agent could selectively accumulate in tumor site after intravenous injection of the cerasome agent into Lewis lung carcinoma tumor bearing mice, resulting in efficient photothermal ablation of tumor through a one-time NIR laser irradiation at the best time window. The ability to track the uptake of cerasomes on a whole body basis could provide researchers with an excellent tool for developing cerasome-based drug delivery agents, especially the strategy of labeling cerasomes with theranostic radionuclide (177)Lu, enabling the ability of the (177)Lu-labeled cerasomes for radionuclide cancer therapy and even the combined therapy. PMID:26398723

  8. The 4f-5d luminescence transitions in cerium-doped LuF3

    NASA Astrophysics Data System (ADS)

    Guerbous, L.; Krachni, O.

    Emission and excitation spectra of the Ce3+ ion in LuF3 single crystal were measured at 77 K. The broad bands observed in these spectra were attributed to the parity-allowed electric-dipole 4f ← 5d transitions within Ce3+ ion. No zero-phonon lines were observed, which is indicative of a strong electron-phonon coupling in this host. It is shown that Ce3+ 5d excited configuration splits into five crystal-field components in LuF3. The influence of the crystalline environment on the position of the lowest Ce3+ 5d level is investigated. The energy of the lowest level of the 4fN-15d excited configuration was predicted for all the trivalent rare earth ions embedded in LuF3. Positions of crystal field spitting levels of 4fN-15d configuration relative to the host electronic bands were discussed.

  9. 177Lu-labeled HPMA Copolymers Utilizing Cathepsin B and S Cleavable Linkers: Synthesis, Characterization and Preliminary In Vivo Investigation in a Pancreatic Cancer Model

    PubMed Central

    Ogbomo, Sunny M.; Shi, Wen; Wagh, Nilesh K; Zhou, Zhengyuan; Brusnahan, Susan K.; Garrison, Jered C.

    2013-01-01

    Introduction A major barrier to the advancement of therapeutic nanomedicines has been the non-target toxicity caused by the accumulation of the drug delivery systems in organs associated with the reticuloendothelial system, particularly the liver and spleen. Herein, we report the development of peptide based metabolically active linkers (MALs) that are enzymatically cleaved by cysteine cathepsin B and S, two proteases highly expressed in the liver and spleen. The overall goal of this approach is to utilize the MALs to lower the non-target retention and toxicity of radiolabeled drug delivery systems, thus resulting in higher diagnostic and radiotherapeutic efficacy. Methods In this study three MALs (MAL0, MAL1 and MAL2) were investigated. MAL1 and MAL2 are composed of known substrates of cathepsin B and S, respectively, while MAL0 is a non-cleavable control. Both MAL1 and MAL2 were shown to undergo enzymatic cleavage with the appropriate cathepsin protease. Subsequent to conjugation to the HPMA copolymer and radiolabeling with 177Lu, the peptide-polymer conjugates were renamed 177Lu- metabolically active copolymers (177Lu-MACs) with the corresponding designation 177Lu-MAC0, 177Lu-MAC1 and 177Lu-MAC2. Results In vivo evaluation of the 177Lu-MACs was performed in a HPAC human pancreatic cancer xenograft mouse model. 177Lu-MAC1 and 177Lu-MAC2 demonstrated 3.1 and 2.1 fold lower liver retention, respectively, compared to control (177Lu-MAC0) at 72 h post-injection. With regard to spleen retention, 177Lu-MAC1 and 177Lu-MAC2 each exhibited a nearly fourfold lower retention, relative to control, at the 72 h time point. However, the tumor accumulation of the 177Lu-MAC0 was two to three times greater than 177Lu-MAC1 and 177Lu-MAC2 at the same time point. The MAL approach demonstrated the capability of substantially reducing the non-target retention of the 177Lu-labeled HPMA copolymers. Conclusions While further studies are needed to optimize the pharmacokinetics of the 177Lu

  10. Excitation function for deuteron induced nuclear reactions on natural ytterbium for production of high specific activity 177g Lu in no-carrier-added form for metabolic radiotherapy.

    PubMed

    Manenti, Simone; Groppi, Flavia; Gandini, Andrea; Gini, Luigi; Abbas, Kamel; Holzwarth, Uwe; Simonelli, Federica; Bonardi, Mauro

    2011-01-01

    Deuteron-induced nuclear reactions for generation of no-carrier-added Lu radionuclides were investigated using the stacked-foil activation technique on natural Yb targets at energies up to E(d)=18.18 MeV. Excitation functions of the reactions (nat)Yb(d,xn)(169,170,171,172,173,174g,174m,176m,177g)Lu and (nat)Yb(d,pxn)(169,175,177)Yb have been measured, among them three ((169)Lu, (174m)Lu and (176m)Lu) are reported for the first time. The upper limit of the contamination from the long-lived metastable level (177m)Lu was evaluated too. Thick-target yields for all investigated radionuclides are calculated.

  11. Gamma camera calibration and validation for quantitative SPECT imaging with (177)Lu.

    PubMed

    D'Arienzo, M; Cazzato, M; Cozzella, M L; Cox, M; D'Andrea, M; Fazio, A; Fenwick, A; Iaccarino, G; Johansson, L; Strigari, L; Ungania, S; De Felice, P

    2016-06-01

    Over the last years (177)Lu has received considerable attention from the clinical nuclear medicine community thanks to its wide range of applications in molecular radiotherapy, especially in peptide-receptor radionuclide therapy (PRRT). In addition to short-range beta particles, (177)Lu emits low energy gamma radiation of 113keV and 208keV that allows gamma camera quantitative imaging. Despite quantitative cancer imaging in molecular radiotherapy having been proven to be a key instrument for the assessment of therapeutic response, at present no general clinically accepted quantitative imaging protocol exists and absolute quantification studies are usually based on individual initiatives. The aim of this work was to develop and evaluate an approach to gamma camera calibration for absolute quantification in tomographic imaging with (177)Lu. We assessed the gamma camera calibration factors for a Philips IRIX and Philips AXIS gamma camera system using various reference geometries, both in air and in water. Images were corrected for the major effects that contribute to image degradation, i.e. attenuation, scatter and dead- time. We validated our method in non-reference geometry using an anthropomorphic torso phantom provided with the liver cavity uniformly filled with (177)LuCl3. Our results showed that calibration factors depend on the particular reference condition. In general, acquisitions performed with the IRIX gamma camera provided good results at 208keV, with agreement within 5% for all geometries. The use of a Jaszczak 16mL hollow sphere in water provided calibration factors capable of recovering the activity in anthropomorphic geometry within 1% for the 208keV peak, for both gamma cameras. The point source provided the poorest results, most likely because scatter and attenuation correction are not incorporated in the calibration factor. However, for both gamma cameras all geometries provided calibration factors capable of recovering the activity in

  12. Importance of the Lu-Hf isotopic system in studies of planetary chronology and chemical evolution

    USGS Publications Warehouse

    Patchett, P.J.

    1983-01-01

    The 176Lu-176Hf isotope method and its applications in earth sciences are discussed. Greater fractionation of Lu/Hf than Sm/Nd in planetary magmatic processes makes 176Hf 177Hf a powerful geochemical tracer. In general, proportional variations of 176Hf 177Hf exceed those of 143Nd l44Nd by factors of 1.5-3 in terrestrial and lunar materials. Lu-Hf studies therefore have a major contribution to make in understanding of terrestrial and other planetary evolution through time, and this is the principal importance of Lu-Hf. New data on basalts from oceanic islands show unequivocally that whereas considerable divergences occur in 176Hf 177Hf- 87Sr 86Sr and 143Nd l44Nd- 87Sr 86Sr diagrams, 176Hf 177Hf and 143Nd 144Nd display a single, linear isotopic variation in the suboceanic mantle. These discordant 87Sr 86Sr relationships may allow, with the acquisition of further Hf-Nd-Sr isotopic data, a distinction between processes such as mantle metasomatism, influence of seawater-altered material in the magma source, or recycling of sediments into the mantle. In order to evaluate the Hf-Nd isotopic correlation in terms of mantle fractionation history, there is a need for measurements of Hf distribution coefficients between silicate minerals and liquids, and specifically for a knowledge of Hf behavior in relation to rareearth elements. For studying ancient terrestrial Hf isotopic variations, the best quality Hf isotope data are obtained from granitoid rocks or zircons. New data show that very U-Pb discordant zircons may have upwardly-biased 176Hf 177Hf, but that at least concordant to slightly discordant zircons appear to be reliable carriers of initial 176Hf 177Hf. Until the controls on addition of radiogenic Hf to zircon are understood, combined zircon-whole rock studies are recommended. Lu-Hf has been demonstrated as a viable tool for dating of ancient terrestrial and extraterrestrial samples, but because it offers little advantage over existing methods, is unlikely to find

  13. Metastatic Bone Pain Palliation using 177Lu-Ethylenediaminetetramethylene Phosphonic Acid

    PubMed Central

    Alavi, Mehrosadat; Omidvari, Shapour; Mehdizadeh, Alireza; Jalilian, Amir R.; Bahrami-Samani, Ali

    2015-01-01

    177Lu-ethylenediaminetetramethylene phosphonic acid (EDTMP) is presently suggested as an excellent bone seeking radionuclide for developing metastatic bone pain (MBP) palliation agent owing to its suitable nuclear decay characteristics. To find the exact dosage and its efficiency, this clinical study was performed on the human being, using 177Lu-EDTMP for MBP palliation. 177Lu-EDTMP was prepared by Iran, atomic energy organization. Thirty consecutive patients with determined tumors, incontrollable MBP, and positive bone scan at 4 weeks before the beginning of the study participated in this study in the nuclear medicine ward. 177Lu-EDTMP in the form of sterile slow IV injection was administered with a dose of 29.6 MBq/kg. Short form of brief pain inventory questionnaire was used to evaluate the efficiency of the intervention. Questionnaires were filled out by an expert nuclear physician every 2 weeks while the cell blood count was also checked every 2 weeks up to 12 weeks for evaluation of bone marrow suppression and hematological toxicity. Furthermore, whole body scan was done at days 1, 3, and 7. Twenty-five patients showed a significant pain relief since 2 weeks after the injection, and continued until the end of the follow up period (12 weeks). There were no significant early complications such as bone marrow suppression, hematological toxicity, and no systemic adverse effects. No complication was observed in renal function. Twenty one patients showed flare phenomenon that was started after the 12.2 ± 1.78 h lasting for 38.4 ± 23.08. Sixteen patients (53%) were completely treated; nine patients (30%) showed a partial response, and five patients (17%) had no response to treatment. Total response to treatment was achieved in 25 patients (83%). At the end of the evaluation, no bone marrow suppression or hematologic toxicity was observed. 177Lu-EDTMP has shown suitable physical and biological properties with good results in long term bone pain relief for patients

  14. Gamma camera calibration and validation for quantitative SPECT imaging with (177)Lu.

    PubMed

    D'Arienzo, M; Cazzato, M; Cozzella, M L; Cox, M; D'Andrea, M; Fazio, A; Fenwick, A; Iaccarino, G; Johansson, L; Strigari, L; Ungania, S; De Felice, P

    2016-06-01

    Over the last years (177)Lu has received considerable attention from the clinical nuclear medicine community thanks to its wide range of applications in molecular radiotherapy, especially in peptide-receptor radionuclide therapy (PRRT). In addition to short-range beta particles, (177)Lu emits low energy gamma radiation of 113keV and 208keV that allows gamma camera quantitative imaging. Despite quantitative cancer imaging in molecular radiotherapy having been proven to be a key instrument for the assessment of therapeutic response, at present no general clinically accepted quantitative imaging protocol exists and absolute quantification studies are usually based on individual initiatives. The aim of this work was to develop and evaluate an approach to gamma camera calibration for absolute quantification in tomographic imaging with (177)Lu. We assessed the gamma camera calibration factors for a Philips IRIX and Philips AXIS gamma camera system using various reference geometries, both in air and in water. Images were corrected for the major effects that contribute to image degradation, i.e. attenuation, scatter and dead- time. We validated our method in non-reference geometry using an anthropomorphic torso phantom provided with the liver cavity uniformly filled with (177)LuCl3. Our results showed that calibration factors depend on the particular reference condition. In general, acquisitions performed with the IRIX gamma camera provided good results at 208keV, with agreement within 5% for all geometries. The use of a Jaszczak 16mL hollow sphere in water provided calibration factors capable of recovering the activity in anthropomorphic geometry within 1% for the 208keV peak, for both gamma cameras. The point source provided the poorest results, most likely because scatter and attenuation correction are not incorporated in the calibration factor. However, for both gamma cameras all geometries provided calibration factors capable of recovering the activity in

  15. Applying Lu-Hf garnet geochronology and inverse phase equilibria modeling to migmatites

    NASA Astrophysics Data System (ADS)

    Yakymchuk, C.; Brown, M.; Vervoort, J. D.

    2013-12-01

    Garnet-bearing assemblages are common in HT metamorphic rocks and are widely used to determine P-T conditions. Garnet is also a host for accessory minerals that may be used to determine the timing of garnet growth or breakdown. However, using accessory minerals to date garnet in HT metamorphic rocks may produce ambiguous or erroneous age results if these minerals were grown or modified subsequently due to fluid or melt infiltration along microfractures. Direct dating of garnet using the Sm-Nd and/or Lu-Hf isotope systems potentially avoids these problems. However, at temperatures above the solidus, the Sm-Nd isotope composition of garnet may become homogenized during post-peak cooling and evidence of prograde growth may be removed. The Lu-Hf isotope system in garnet is more robust and less susceptible to diffusion-controlled re-equilibration. Therefore, Lu-Hf dating of garnet has the potential to constrain the period of prograde garnet growth in HT metamorphic rocks. In the Fosdick migmatite-granite complex of West Antarctica, two episodes of HT garnet growth have been proposed based on U-Pb monazite ages from garnet-bearing migmatitic paragneisses and orthogneisses and U-Pb zircon ages from spatially associated peraluminous granites. Cores of monazite inclusions in garnet yield Carboniferous ages whereas the rims yield Cretaceous ages, and the garnet itself records Cretaceous Sm-Nd ages. The Sm-Nd ages were interpreted to represent diffusional resetting during the Cretaceous of garnet that grew in the Carboniferous. In this study, Lu-Hf garnet geochronology is used to test the hypothesis that garnet in the migmatitic paragneisses and orthogneisses is Carboniferous in age. We also assess the utility of the Lu-Hf system for dating garnet growth in rocks that have experienced superimposed HT metamorphic events. In addition, inverse phase equilibria modeling of open system melting is used to constrain the P-T conditions of garnet growth in migmatitic paragneisses and

  16. Synthesis of Oligosaccharides Derived from Lactulose (OsLu) Using Soluble and Immobilized Aspergillus oryzae β-Galactosidase.

    PubMed

    Cardelle-Cobas, Alejandra; Olano, Agustin; Irazoqui, Gabriela; Giacomini, Cecilia; Batista-Viera, Francisco; Corzo, Nieves; Corzo-Martínez, Marta

    2016-01-01

    β-Galactosidase from Aspergillus oryzae offers a high yield for the synthesis of oligosaccharides derived from lactulose (OsLu) by transgalactosylation. Oligosaccharides with degree of polymerization (DP) ≥ 3 have shown to possess higher in vitro bifidogenic effect than di- and tetrasaccharides. Thus, in this work, an optimization of reaction conditions affecting the specific selectivity of A. oryzae β-galactosidase for synthesis of OsLu has been carried out to enhance OsLu with DP ≥ 3 production. Assays with β-galactosidase immobilized onto a glutaraldehyde-agarose support were also carried out with the aim of making the process cost-effective and industrially viable. Optimal conditions with both soluble and immobilized enzyme for the synthesis of OsLu with DP ≥ 3 were 50 °C, pH 6.5, 450 g/L of lactulose, and 8 U/mL of enzyme, reaching yields of ca. 50% (w/v) of total OsLu and ca. 20% (w/v) of OsLu with DP 3, being 6'-galactosyl-lactulose the major one, after a short reaction time. Selective formation of disaccharides, however, was favored at 60 °C, pH 4.5, 450 g/L of lactulose and 8 U/mL of enzyme. Immobilization increased the enzymatic stability to temperature changes and allowed to reuse the enzyme. We can conclude that the use, under determined optimal conditions, of the A. oryzae β-galactosidase immobilized on a support of glutaraldehyde-agarose constitutes an efficient and cost-effective alternative to the use of soluble β-galactosidases for the synthesis of prebiotic OsLu mixtures.

  17. Synthesis of Oligosaccharides Derived from Lactulose (OsLu) Using Soluble and Immobilized Aspergillus oryzae β-Galactosidase

    PubMed Central

    Cardelle-Cobas, Alejandra; Olano, Agustin; Irazoqui, Gabriela; Giacomini, Cecilia; Batista-Viera, Francisco; Corzo, Nieves; Corzo-Martínez, Marta

    2016-01-01

    β-Galactosidase from Aspergillus oryzae offers a high yield for the synthesis of oligosaccharides derived from lactulose (OsLu) by transgalactosylation. Oligosaccharides with degree of polymerization (DP) ≥ 3 have shown to possess higher in vitro bifidogenic effect than di- and tetrasaccharides. Thus, in this work, an optimization of reaction conditions affecting the specific selectivity of A. oryzae β-galactosidase for synthesis of OsLu has been carried out to enhance OsLu with DP ≥ 3 production. Assays with β-galactosidase immobilized onto a glutaraldehyde–agarose support were also carried out with the aim of making the process cost-effective and industrially viable. Optimal conditions with both soluble and immobilized enzyme for the synthesis of OsLu with DP ≥ 3 were 50 °C, pH 6.5, 450 g/L of lactulose, and 8 U/mL of enzyme, reaching yields of ca. 50% (w/v) of total OsLu and ca. 20% (w/v) of OsLu with DP 3, being 6′-galactosyl-lactulose the major one, after a short reaction time. Selective formation of disaccharides, however, was favored at 60 °C, pH 4.5, 450 g/L of lactulose and 8 U/mL of enzyme. Immobilization increased the enzymatic stability to temperature changes and allowed to reuse the enzyme. We can conclude that the use, under determined optimal conditions, of the A. oryzae β-galactosidase immobilized on a support of glutaraldehyde–agarose constitutes an efficient and cost-effective alternative to the use of soluble β-galactosidases for the synthesis of prebiotic OsLu mixtures. PMID:27014684

  18. Pharmacokinetics and biodistribution of intravenous Lu-177 CC49 murine monoclonal antibody (MAb) in patients with metastatic adenocarcinoma

    SciTech Connect

    Carrasquillo, J.; Mulligan, T.; Chung, Y.

    1994-05-01

    The pharmacokinetics of Lu-177 labeled CG49, a murine monoclonal antibody that is undergoing testing for radioimmunotherapy, was evaluated. CC49 is a second generation murine MAb that recognizes TAG-72, a pan-carcinoma tumor associated antigen. Labeling of CC49 MAb with Lu-177, a beta emitter was performed by first labeling a derivative of 1,4,5,10-tetraazacyclododecane-tetraacetic acid (PA-DOTA) with Lu-177 and then attaching the Lu-177 labeled PA-DOTA to CC49. CC49 was labeled with Lu-177 at a maximum specific activity of 185 MBq/mg. HPLC showed 96-100% protein bound Lu-177 and <4% aggregate formation. A Phase I dose escalation study was performed. Nine patients with TAG-72 positive, advanced metastatic adenocarcinoma (5- breast, 3- colorectal and 1- lung) were treated with escalating iv doses of Lu-177-(PA-DOTA) CC49: 370 MBq/m2, 555 MBq/m2 and 925 MBq/m2 (range 560-1575 MBq). Pharmacokinetics showed that the plasma cleared with a T1/2 of {approximately}67 hrs which is in the range seen with I-131 CC49. The whole body retention of Lu-177 was prolonged with a biological T1/2 of 223 hr. Urinary excretion ranged from 7 to 26% in the first 96 hrs. Serial images showed early blood pool distribution with prominent uptake in the liver, spleen and marrow. Some intestinal excretion was noted. Tumor imaging was seen in all patients although riot all tumors were visualized. Bone marrow biopsies were obtained in all patients and suggested that the accumulation seen on scan was predominantly in the marrow rather than the bone. MIRDOSE estimates from the first 6 patients suggested doses to the marrow in the range of {approximately}4 cG/37 MBq. This study indicated that while the serum pharmacokinetics of Lu-177-(PA-DOTA)-CC49 are similar to those seen with I-131 CC49, the whole body retention and bone marrow accumulation are different and therefore require further investigation to minimize the bone marrow accumulation.

  19. Comparative efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

    DOE PAGES

    Frost, Sofia H. L.; Frayo, Shani L.; Miller, Brian W.; Orozco, Johnnie J.; Booth, Garrett C.; Hylarides, Mark D.; Lin, Yukang; Green, Damian J.; Gopal, Ajay K.; Pagel, John M.; et al

    2015-03-18

    Purpose Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targetingmore » either 90Y or 177Lu to human B-cell lymphoma xenografts in mice. Methods Parallel experiments evaluating the biodistribution, imaging, dosimetry, therapeutic efficacy, and toxicity were performed in female athymic nude mice bearing either Ramos (Burkitt lymphoma) or Granta (mantle cell lymphoma) xenografts, utilizing an anti-CD20 antibodystreptavidin conjugate (1F5-SA) and an 90Y- or 177Lu-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-biotin second step reagent. Results The two radionuclides displayed comparable biodistributions in tumors and normal organs; however, the absorbed radiation dose delivered to tumor was more than twice as high for 90Y (1.3 Gy/MBq) as for 177Lu (0.6 Gy/MBq). More importantly, therapy with 90Y-DOTAbiotin was dramatically more effective than with 177Lu-DOTA-biotin, with 100% of Ramos xenograft-bearing mice cured with 37 MBq 90Y, whereas 0% were cured using identical amounts of 177Lu-DOTA-biotin. Similar results were observed in mice bearing Granta xenografts, with 80% of the mice cured with 90Y-PRIT and 0% cured with 177Lu-PRIT. Toxicities were comparable with both isotopes. Conclusion 90Y was therapeutically superior to 177Lu for streptavidin-biotin PRIT

  20. Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

    PubMed Central

    Frost, Sofia H. L.; Frayo, Shani L.; Miller, Brian W.; Orozco, Johnnie J.; Booth, Garrett C.; Hylarides, Mark D.; Lin, Yukang; Green, Damian J.; Gopal, Ajay K.; Pagel, John M.; Bäck, Tom A.; Fisher, Darrell R.; Press, Oliver W.

    2015-01-01

    Purpose Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice. Methods Parallel experiments evaluating the biodistribution, imaging, dosimetry, therapeutic efficacy, and toxicity were performed in female athymic nude mice bearing either Ramos (Burkitt lymphoma) or Granta (mantle cell lymphoma) xenografts, utilizing an anti-CD20 antibody-streptavidin conjugate (1F5-SA) and an 90Y- or 177Lu-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-biotin second step reagent. Results The two radionuclides displayed comparable biodistributions in tumors and normal organs; however, the absorbed radiation dose delivered to tumor was more than twice as high for 90Y (1.3 Gy/MBq) as for 177Lu (0.6 Gy/MBq). More importantly, therapy with 90Y-DOTA-biotin was dramatically more effective than with 177Lu-DOTA-biotin, with 100% of Ramos xenograft-bearing mice cured with 37 MBq 90Y, whereas 0% were cured using identical amounts of 177Lu-DOTA-biotin. Similar results were observed in mice bearing Granta xenografts, with 80% of the mice cured with 90Y-PRIT and 0% cured with 177Lu-PRIT. Toxicities were comparable with both isotopes. Conclusion 90Y was therapeutically superior to 177Lu for streptavidin-biotin PRIT approaches in

  1. The locus for apolipoprotein E (apoE) is close to the Lutheran (Lu) blood group locus on chromosome 19.

    PubMed

    Gedde-Dahl, T; Olaisen, B; Teisberg, P; Wilhelmy, M C; Mevåg, B; Helland, R

    1984-01-01

    Linkage has been described between the loci for apolipoprotein E (apoE) and the complement C3 (C3) on chromosome 19. C3 is known to belong to a linkage group with gene order C3-Se-Lu. The present study revealed linkage between Se and apoE with peak lod score +3.3 at recombination fraction 0.08 in males and +1.36 at 0.22 in females, and linkage between apoE and Lu with lod score +4.52 at zero recombination in sexes combined. The C3-apoE linkage gives lod score +4.00 at theta = 0.18 in males, but +0.04 at theta = 0.45 in females. Triple heterozygote families confirm that apoE is on the Se side and on the Lu side of C3. Allelic association between apoE and Lu has not been ruled out. Combining our data with published data on C3-Se and Se-Lu, this segment of chromosome 19 has an average age sex ratio of female/male recombination of 2.3.

  2. Development of (177)Lu-DOTA-Dendrimer and Determination of Its Effect on Metal and Ion Levels in Tumor Tissue.

    PubMed

    Kovacs, Luciana; Tassano, Marcos; Cabrera, Mirel; Zamboni, Cibele B; Fernández, Marcelo; Anjos, Roberto M; Cabral, Pablo

    2015-12-01

    Dendrimers are synthetic nanomolecules with well-defined chemical structures. Different strategies have been used for radiolabeling dendrimers with different radioisotopes. In this study, the aim was to conjugate dendrimers with (177)Lu, to observe the in vivo behavior of the labeled compound and to measure the elementary changes in tumor tissue that could be caused by ionizing radiation. PAMAM G4 dendrimers conjugated with DOTA were labeled with (177)Lu. The radiolabeled compound was characterized and its stability was evaluated by reverse phase high performance liquid chromatography. Radiolabeling yield was >98% and stable for 24 hours. Biodistribution studies of (177)Lu-DOTA-dendrimers in C57BL/6 melanoma-bearing mice showed blood clearance with hepatic and renal depuration and tumor uptake. The concentrations of Br, Ca, Cl, Fe, K, Mg, Na, Rb, S, and Zn were determined in tumor tissues of C57BL/6 mice treated with (177)Lu-DOTA-dendrimers and in untreated mice. The results showed decreased concentrations of Br (62%), Ca (24%), Cl (51%), K (12%) and Na (60%) and increased concentrations of Fe (8%), Mg (28%), Rb (100%), S (6%) and Zn (4%) in tumor tissues of mice treated with (177)Lu-DOTA-dendrimers. These data may be useful to evaluate changes in tumor tissues as indicators of damage that could be caused by ionizing radiation.

  3. H4octapa-Trastuzumab: Versatile Acyclic Chelate System for 111In and 177Lu Imaging and Therapy

    PubMed Central

    Price, Eric W.; Zeglis, Brian M.; Cawthray, Jacqueline F.; Ramogida, Caterina F.; Ramos, Nicholas

    2013-01-01

    A bifunctional derivative of the versatile acyclic chelator H4octapa, p-SCNBn- H4octapa, has been synthesized for the first time. The chelator was conjugated to the HER2/neu-targeting antibody trastuzumab and labeled in high radiochemical purity and specific activity with the radioisotopes 111In and 177Lu. The in vivo behavior of the resulting radioimmunoconjugates was investigated in mice bearing ovarian cancer xenografts and compared to analogous radioimmunoconjugates employing the ubiquitous chelator DOTA. The H4octapa-trastuzumab conjugates displayed faster radiolabeling kinetics with more reproducible yields under milder conditions (15 min, RT, ~94–95%) than those based on DOTA-trastuzumab (60 min, 37 °C ~50–88%). Further, antibody integrity was better preserved in the 111In- and 177Lu-octapatrastuzumab constructs, with immunoreactive fractions of 0.99 for each compared to 0.93–0.95 for 111In- and 177Lu-DOTA-trastuzumab. These results translated to improved in vivo biodistribution profiles and SPECT imaging results for 111In- and 177Lu-octapa-trastuzumab compared to 111In- and 177Lu-DOTA-trastuzumab, with increased tumor uptake and higher tumor-to-tissue activity ratios. PMID:23901833

  4. High-pressure polymorph of LuFe2O4 with room-temperature antiferromagnetic order

    NASA Astrophysics Data System (ADS)

    Damay, F.; Poienar, M.; Hervieu, M.; Guesdon, A.; Bourgeois, J.; Hansen, T.; Elkaïm, E.; Haines, J.; Hermet, P.; Konczewicz, L.; Hammouda, T.; Rouquette, J.; Martin, C.

    2015-06-01

    Branded for its potential electronic ferroelectricity, charge-ordered LuF e2O4 has a layered Fe triangular framework, whose topology is a source of degeneracy, both at the charge and spin levels. Here we present an in-depth characterization of LuF e2O4-h p , the high-pressure (h p ) polymorph of LuF e2O4 , using electron, x-ray, and neutron diffraction, combined with transport and magnetization measurements. We show that LuF e2O4-h p is characterized by a misfit-related monoclinic structure, accommodating a buckled triangular [Lu] ∞ layer and two shifted adjacent rectangular [Fe] ∞ planes belonging to a distorted rock salt-type layer. The release of the geometric frustration of the Fe magnetic lattice in the h p form leads to collinear antiferromagnetic ordering at TN=380 K . Possible coexistence of charge and magnetic orders in this material opens research pathways for the design of tunable multifunctional devices using high-pressure techniques.

  5. 176Lu/176Hf: A Sensitive Test of s-Process Temperature and Neutron Density in AGB Stars

    NASA Astrophysics Data System (ADS)

    Heil, M.; Winckler, N.; Dababneh, S.; Käppeler, F.; Wisshak, K.; Bisterzo, S.; Gallino, R.; Davis, A. M.; Rauscher, T.

    2008-01-01

    The s-process branching at A = 176 has been analyzed on the basis of significantly improved experimental cross sections. This work reports on activation measurements of the partial (n,γ ) cross section of 176Lu feeding the isomeric state in 176Lu. In total, six irradiations were performed at the Karlsruhe 3.7 MV pulsed Van de Graaff accelerator, and the induced activities were measured with HPGe clover detectors. In combination with previous data, partial cross sections of 3185 +/- 156 and 1153 +/- 30 mbarn were deduced at kT = 5.1 and 25 keV, respectively. With these results and a recent time-of-flight measurement of the total stellar (n,γ ) cross section, the isomeric ratio was found to be constant in the relevant thermal energy range of the main s-process component. Based on these new data, a comprehensive analysis of the branching at 176Lu was carried out for testing the temperature and neutron density conditions during He shell flashes in thermally pulsing low-mass asymptotic giant branch stars. It was found that the long-standing problem of the mother/daughter ratio of the two s-only isotopes 176Lu and 176Hf could be solved, if the temperature-dependent β-decay half-life of 176Lu was considered with sufficient resolution over the temperature profile of the convective He shell flashes.

  6. On the structural origin of the single-ion magnetic anisotropy in LuFeO3.

    PubMed

    Cao, Shi; Zhang, Xiaozhe; Paudel, Tula R; Sinha, Kishan; Wang, Xiao; Jiang, Xuanyuan; Wang, Wenbin; Brutsche, Stuart; Wang, Jian; Ryan, Philip J; Kim, Jong-Woo; Cheng, Xuemei; Tsymbal, Evgeny Y; Dowben, Peter A; Xu, Xiaoshan

    2016-04-20

    The electronic structure for the conduction bands of both hexagonal and orthorhombic LuFeO3 thin films have been measured using x-ray absorption spectroscopy at oxygen K (O K) edge. Dramatic differences in both the spectral features and the linear dichroism are observed. These differences in the spectra can be explained using the differences in crystal field splitting of the metal (Fe and Lu) electronic states and the differences in O 2p-Fe 3d and O 2p-Lu 5d hybridizations. While the oxidation states have not changed, the spectra are sensitive to the changes in the local environments of the Fe(3+) and Lu(3+) sites in the hexagonal and orthorhombic structures. Using the crystal-field splitting and the hybridizations that are extracted from the measured electronic structures and the structural distortion information, we derived the occupancies of the spin minority states in Fe(3+), which are non-zero and uneven. The single ion anisotropy on Fe(3+) sites is found to originate from these uneven occupancies of the spin minority states via spin-orbit coupling in LuFeO3. PMID:26982512

  7. Development of (177)Lu-DOTA-Dendrimer and Determination of Its Effect on Metal and Ion Levels in Tumor Tissue.

    PubMed

    Kovacs, Luciana; Tassano, Marcos; Cabrera, Mirel; Zamboni, Cibele B; Fernández, Marcelo; Anjos, Roberto M; Cabral, Pablo

    2015-12-01

    Dendrimers are synthetic nanomolecules with well-defined chemical structures. Different strategies have been used for radiolabeling dendrimers with different radioisotopes. In this study, the aim was to conjugate dendrimers with (177)Lu, to observe the in vivo behavior of the labeled compound and to measure the elementary changes in tumor tissue that could be caused by ionizing radiation. PAMAM G4 dendrimers conjugated with DOTA were labeled with (177)Lu. The radiolabeled compound was characterized and its stability was evaluated by reverse phase high performance liquid chromatography. Radiolabeling yield was >98% and stable for 24 hours. Biodistribution studies of (177)Lu-DOTA-dendrimers in C57BL/6 melanoma-bearing mice showed blood clearance with hepatic and renal depuration and tumor uptake. The concentrations of Br, Ca, Cl, Fe, K, Mg, Na, Rb, S, and Zn were determined in tumor tissues of C57BL/6 mice treated with (177)Lu-DOTA-dendrimers and in untreated mice. The results showed decreased concentrations of Br (62%), Ca (24%), Cl (51%), K (12%) and Na (60%) and increased concentrations of Fe (8%), Mg (28%), Rb (100%), S (6%) and Zn (4%) in tumor tissues of mice treated with (177)Lu-DOTA-dendrimers. These data may be useful to evaluate changes in tumor tissues as indicators of damage that could be caused by ionizing radiation. PMID:26625257

  8. Multiscale Modeling of Drug-induced Effects of ReDuNing Injection on Human Disease: From Drug Molecules to Clinical Symptoms of Disease

    NASA Astrophysics Data System (ADS)

    Luo, Fang; Gu, Jiangyong; Zhang, Xinzhuang; Chen, Lirong; Cao, Liang; Li, Na; Wang, Zhenzhong; Xiao, Wei; Xu, Xiaojie

    2015-05-01

    ReDuNing injection (RDN) is a patented traditional Chinese medicine, and the components of it were proven to have antiviral and important anti-inflammatory activities. Several reports showed that RDN had potential effects in the treatment of influenza and pneumonia. Though there were several experimental reports about RDN, the experimental results were not enough and complete due to that it was difficult to predict and verify the effect of RDN for a large number of human diseases. Here we employed multiscale model by integrating molecular docking, network pharmacology and the clinical symptoms information of diseases and explored the interaction mechanism of RDN on human diseases. Meanwhile, we analyzed the relation among the drug molecules, target proteins, biological pathways, human diseases and the clinical symptoms about it. Then we predicted potential active ingredients of RDN, the potential target proteins, the key pathways and related diseases. These attempts may offer several new insights to understand the pharmacological properties of RDN and provide benefit for its new clinical applications and research.

  9. Impact of parameter fluctuations on the performance of ethanol precipitation in production of Re Du Ning Injections, based on HPLC fingerprints and principal component analysis.

    PubMed

    Sun, Li-Qiong; Wang, Shu-Yao; Li, Yan-Jing; Wang, Yong-Xiang; Wang, Zhen-Zhong; Huang, Wen-Zhe; Wang, Yue-Sheng; Bi, Yu-An; Ding, Gang; Xiao, Wei

    2016-01-01

    The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections, including concentrate density, concentrate temperature, ethanol content, flow rate and stir rate in the addition of ethanol, precipitation time, and precipitation temperature. Under the experimental and simulated production conditions, a series of precipitated resultants were prepared by changing these variables one by one, and then examined by HPLC fingerprint analyses. Different from the traditional evaluation model based on single or a few constituents, the fingerprint data of every parameter fluctuation test was processed with Principal Component Analysis (PCA) to comprehensively assess the performance of ethanol precipitation. Our results showed that concentrate density, ethanol content, and precipitation time were the most important parameters that influence the recovery of active compounds in precipitation resultants. The present study would provide some reference for pharmaceutical scientists engaged in research on pharmaceutical process optimization and help pharmaceutical enterprises adapt a scientific and reasonable cost-effective approach to ensure the batch-to-batch quality consistency of the final products.

  10. Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus

    PubMed Central

    Wang, Ling; Qiu, Xue-Min; Gui, Yu-Yan; Xu, Ying-Ping; Gober, Hans-Jürgen; Li, Da-Jin

    2015-01-01

    Introduction Bu-Shen-Ning-Xin Decoction (BSNXD), a traditional Chinese medicinal composition, has been used as a remedy for postmenopausal osteoporosis, but its effects on bone metabolism and the uterus have not been reported. Purpose We aimed to determine the respective effects of BSNXD on the bones and the uterus of ovariectomized (OVX) mice to evaluate the efficacy and safety of this herbal formula. Materials and methods Postmenopausal osteoporosis animal models that were generated by ovariectomy were treated with BSNXD. Dual-energy X-ray absorptiometry was performed to analyze the bone mineral density, and histomorphometric analysis was performed to measure the parameters related to bone metabolism. Calcein labeling was performed to detect bone formation. The uteruses from the mice were weighed, and the histomorphometry was analyzed. Drug-derived serum was prepared to assess the 17-β-estradiol concentration via enzyme immunoassay. Results BSNXD administration ameliorated the osteoporotic phenotype of OVX mice, as evidenced by an increase in the bone mineral density and bone volume; these effects could not be abolished by the administration of the aromatase inhibitor letrozole. Moreover, BSNXD had no effect on the serum estrogen concentration or uterus. Conclusion These results suggest that BSNXD has ameliorating effects on bone loss due to estrogen deprivation without affecting the peripheral blood estrogen concentration or the uterus in OVX mice. PMID:26357466

  11. (90) Y/(177) Lu-labelled Cetuximab immunoconjugates: radiochemistry optimization to clinical dose formulation.

    PubMed

    Chakravarty, Rubel; Chakraborty, Sudipta; Sarma, Haladhar Dev; Nair, K V Vimalnath; Rajeswari, Ardhi; Dash, Ashutosh

    2016-07-01

    Radiolabelled monoclonal antibodies (mAbs) are increasingly being utilized in cancer theranostics, which is a significant move toward tailored treatment for individual patients. Cetuximab is a recombinant, human-mouse chimeric IgG1 mAb that binds to the epidermal growth factor receptor with high affinity. We have optimized a protocol for formulation of clinically relevant doses (~2.22 GBq) of (90) Y-labelled Cetuximab and (177) Lu-labelled Cetuximab by conjugation of the mAb with a suitable bifunctional chelator, N-[(R)-2-amino-3-(paraisothiocyanato-phenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N″,N″-pentaacetic acid (CHX-A″-DTPA). The radioimmunoconjugates demonstrated reasonably high specific activity (1.26 ± 0.27 GBq/mg for (90) Y-CHX-A″-DTPA-Cetuximab and 1.14 ± 0.15 GBq/mg for (177) Lu-CHX-A″-DTPA-Cetuximab), high radiochemical purity (>95%) and appreciable in vitro stability under physiological conditions. Preliminary biodistribution studies with both (90) Y-CHX-A″-DTPA-Cetuximab and (177) Lu-CHX-A″-DTPA-Cetuximab in Swiss mice bearing fibrosarcoma tumours demonstrated significant tumour uptake at 24-h post-injection (p.i.) (~16%ID/g) with good tumour-to-background contrast. The results of the biodistribution studies were further corroborated by ex vivo Cerenkov luminescence imaging after administration of (90) Y-CHX-A″-DTPA-Cetuximab in tumour-bearing mice. The tumour uptake at 24 h p.i. was significantly reduced with excess unlabelled Cetuximab, suggesting that the uptake was receptor mediated. The results of this study hold promise, and this strategy should be further explored for clinical translation. PMID:27264196

  12. The Lung Reporting and Data System (LU-RADS): a proposal for computed tomography screening.

    PubMed

    Manos, Daria; Seely, Jean M; Taylor, Jana; Borgaonkar, Joy; Roberts, Heidi C; Mayo, John R

    2014-05-01

    Despite the positive outcome of the recent randomized trial of computed tomography (CT) screening for lung cancer, substantial implementation challenges remain, including the clear reporting of relative risk and suggested workup of screen-detected nodules. Based on current literature, we propose a 6-level Lung-Reporting and Data System (LU-RADS) that classifies screening CTs by the nodule with the highest malignancy risk. As the LU-RADS level increases, the risk of malignancy increases. The LU-RADS level is linked directly to suggested follow-up pathways. Compared with current narrative reporting, this structure should improve communication with patients and clinicians, and provide a data collection framework to facilitate screening program evaluation and radiologist training. In overview, category 1 includes CTs with no nodules and returns the subject to routine screening. Category 2 scans harbor minimal risk, including <5 mm, perifissural, or long-term stable nodules that require no further workup before the next routine screening CT. Category 3 scans contain indeterminate nodules and require CT follow up with the interval dependent on nodule size (small [5-9 mm] or large [≥ 10 mm] and possibly transient). Category 4 scans are suspicious and are subdivided into 4A, low risk of malignancy; 4B, likely low-grade adenocarcinoma; and 4C, likely malignant. The 4B and 4C nodules have a high likelihood of neoplasm simply based on screening CT features, even if positron emission tomography, needle biopsy, and/or bronchoscopy are negative. Category 5 nodules demonstrate frankly malignant behavior on screening CT, and category 6 scans contain tissue-proven malignancies.

  13. A study of response of a LuYAP:Ce array with innovative assembling for PET

    NASA Astrophysics Data System (ADS)

    Pani, Roberto; Cinti, Maria Nerina; Scafè, Raffaele; Bennati, Paolo; Lo Meo, Sergio; Preziosi, Enrico; Pellegrini, Rosanna; De Vincentis, Giuseppe; Sacco, Donatella; Fabbri, Andrea

    2015-09-01

    We propose the characterization of a first array of 10×10 Lutetium Yttrium Orthoaluminate Perovskite (LuYAP:Ce) crystals, 2 mm×2 mm×10 mm pixel size, with an innovative assembling designed to enhance light output, uniformity and detection efficiency. The innovation consists of the use of 0.015 mm thick dielectric coating as inter-pixel light-insulators, manufactured by Crytur (Czech Republic) intended to improve crystal insulation and then light collection. Respect to the traditional treatment with 0.2 mm of white epoxy, a thinner pixel gap enhances packing fraction up to 98% with a consequent improvement of detection efficiency. Spectroscopic characterization of the array was performed by a Hamamatsu R6231 photomultiplier tube. A pixel-by-pixel scanning with a collimated 99mTc radioisotope (140 keV photon energy) highlighted a deviation in pulse height close to 3.5% respect to the overall mean value. Meanwhile, in term of energy resolution a difference between the response of single pixel and the array of about 10% was measured. Results were also supported and validated by Monte Carlo simulations performed with GEANT4. Although the dielectric coating pixel insulator cannot overcome the inherent limitations of LuYAP crystal due to its self-absorption of light (still present), this study demonstrated that the new coating treatment allows better light collection (nearly close to the expected one) with in addition a very good uniformity between different pixels. These results confirm the high potentiality of this coating for any other crystal array suited for imaging application and new expectations for the use of LuYAP for PET systems.

  14. Time over threshold based multi-channel LuAG-APD PET detector

    NASA Astrophysics Data System (ADS)

    Shimazoe, Kenji; Orita, Tadashi; Nakamura, Yasuaki; Takahashi, Hiroyuki

    2013-12-01

    To achieve efficient signal processing, several time-based positron emission tomography (PET) systems using a large number of granulated gamma-ray detectors have recently been proposed. In this work described here, a 144-channel Pr:LuAG avalanche photodiode (APD) PET detector that uses time over threshold (ToT) and pulse train methods was designed and fabricated. The detector is composed of 12×12 Pr:LuAG crystals, each of which produces a 2 mm×2 mm×10 mm pixel individually coupled to a 12×12 APD array, which in turn is connected pixel-by-pixel with one channel of a time over threshold based application-specific integrated circuit (ToT-ASIC) that was designed and fabricated using a 0.25 μm 3.3 V Taiwan Semiconductor Company complementary metal oxide semiconductor (TSMC CMOS) process. The ToT outputs are connected through a field-programmable gate array (FPGA) to a data acquisition (DAQ) system. Three front-end ASIC boards-each incorporating a ToT-ASIC chip, threshold control digital-to-analog converters (DACs), and connectors, and dissipating power at about 230 mW per board-are used to read from the 144-channel LuAG-APD detector. All three boards are connected through an FPGA board that is programmed to calibrate the individual thresholds of the ToT circuits to allow digital multiplexing to form an integrated PET module with a measured timing resolution of 4.2 ns. Images transmitted by this PET system can be successfully acquired through collimation masks. As a further implementation of this technology, an animal PET system consisting of eight gamma pixel modules forming a ring is planned.

  15. Thermal-expansion measurements for Lu5Ir4Si10, Lu5Rh4Si10, Sc5Ir4Si10, and Tm5Ir4Si10: Charge-density-wave effects

    NASA Astrophysics Data System (ADS)

    Swenson, C. A.; Shelton, R. N.; Klavins, P.; Yang, H. D.

    1991-04-01

    Linear-thermal-expansion measurements have determined the small relative length changes (ΔL/L~=-10-4) at the charge-density-wave (CDW) transitions in Lu5Ir4Si10, Lu5Rh4Si10, and Tm5Ir4Si10. Tm5Ir4Si10 shows a second sluggish transition near 18+/-8 K which is comparable in magnitude. Thermal-expansivity measurements show that, for each material, significant changes occur in lattice properties on cooling through the CDW transition. Expansivity data above the low-temperature ordering transitions for these three (Lu5Ir4Si10, Lu5Rh4Si10 superconducting; Tm5Ir4Si10, magnetic) and also for Sc5Ir4Si10 (no CDW, but superconducting) in combination with previous CP results show unusual electronic behavior (large electronic contributions to α for all except Lu5Ir4Si10), a positive lattice expansivity only for Lu5Ir4Si10, and a very large lattice expansivity for Tm5Ir4Si10. The lattice Grüneisen parameters for the superconducting compounds show significant temperature dependence. A comparison of the pressure dependences of the superconducting transition temperatures (dTc/dP) as calculated from the discontinuities in α and CP and as determined in high-pressure experiments suggests a complex Tc(P) behavior. The magnetic contributions to the expansivity of Tm5Ir4Si10 are consistent with different signs for dTc/dP for the 1.9-K ordering transition studied in these experiments and for the 0.86-K transition which has been observed in CP measurements.

  16. Multitasking the INS3D-LU code on the Cray Y-MP

    NASA Technical Reports Server (NTRS)

    Fatoohi, Rod; Yoon, Seokkwan

    1991-01-01

    This paper presents the results of multitasking the INS3D-LU code on eight processors. The code is a full Navier-Stokes solver for incompressible fluid in three dimensional generalized coordinates using a lower-upper symmetric-Gauss-Seidel implicit scheme. This code has been fully vectorized on oblique planes of sweep and parallelized using autotasking with some directives and minor modifications. The timing results for five grid sizes are presented and analyzed. The code has achieved a processing rate of over one Gflops.

  17. Diode-pumped intra-cavity doubled Nd:LuVO 4 laser at 458 nm

    NASA Astrophysics Data System (ADS)

    He, Kunna; Gao, Chunqing; Wei, Zhiyi; Li, Dehua; Zhang, Zhiguo; Zhang, HuaiJin; Wang, Jiyang

    2008-07-01

    We have demonstrated a diode-pumped intra-cavity frequency doubling Nd:LuVO 4 laser operating at 916 nm with a Z-folded cavity. A 10-mm long LBO crystal, cut for critical type I phase matching at 912 nm, is used for the experiment. A maximum output power of 330 mW at 458 nm has been achieved at pump power of 22 W. The optical-to-optical conversion efficiency and slope efficiency is 1.5% and 2.3%, respectively. The power instability at the maximum output power in 30 min is better than 3%.

  18. Magnetoelectric coupling in hexagonal LuFeO3 thin films

    NASA Astrophysics Data System (ADS)

    Liu, Hao

    The magnetic and polar properties of single-crystalline hexagonal LuFeO3 films have been studied. Both theoretical and experimental approaches indicated the coexisting of multiple ferroic orders. The spontaneous electric polarization is associated with a structural change, which also influences the magnetic properties, predicting a strong magnetoelectric coupling in these films. To investigate the magnetoelectric coupling, the micro capacitance structures were fabricated by photolithography combined with Ar ion beam etching method. The capacitance vs voltage curves show significant magnetic field effect, indicating strong magnetoelectric coupling in this system.

  19. High power, high repetition rate, few picosecond Nd:LuVO₄ oscillator with cavity dumping.

    PubMed

    Gao, Peng; Guo, Jie; Li, Jinfeng; Lin, Hua; Yu, Haohai; Zhang, Huaijin; Liang, Xiaoyan

    2015-12-28

    We investigate the potential use of Nd:LuVO4 in high average power, high repetition rate ultrafast lasers. Maximum mode-locked average power of 28 W is obtained at the repetition rate of 58 MHz. The shortest pulse duration is achieved at 4 ps without dispersion compensation. With a cavity dumping technique, the pulse energy is scaling up to 40.7 μJ at 300 kHz and 14.3 μJ at 1.5 MHz. PMID:26831955

  20. Topological band order, structural, electronic and optical properties of XPdBi (X = Lu, Sc) compounds

    NASA Astrophysics Data System (ADS)

    Narimani, M.; Nourbakhsh, Z.

    2016-05-01

    In this paper, the structural, electronic and optical properties of LuPdBi and ScPdBi compounds are investigated using the density functional theory by WIEN2K package within the generalized gradient approximation, local density approximation, Engel-Vosco generalized gradient approximations and modified Becke-Johnson potential approaches. The topological phases and band orders of these compounds are studied. The effect of pressure on band inversion strength, electron density of states and the linear coefficient of the electronic specific heat of these compounds is investigated. Furthermore, the effect of pressure on real and imaginary parts of dielectric function, absorption and reflectivity coefficients of these compounds is studied.

  1. Performance evaluation and enhancement of SuperLU{_}DIST 2.0

    SciTech Connect

    Li, Xiaoye S.; Wang, Yu

    2003-08-28

    We present the runtime comparison of the two versions of Super LU{_}DIST, using up to 128 processors of the IBM SP at NERSC. One version provides the global input interface, and another provides the distributed input interface. The comparison includes the total runtime of the solver with both 32-bit and 64-bit addressing modes, the time breakdown for different phases of the solver. We also present an in-depth comparison off our sparse matrix-vector multiplication methods in the context of iterative refinement. Finally, we describe our Fortran 90 interface that enhances the usability of the software.

  2. Cloverleaf domain patterns in multiferroic RMnO3 (R = Ho, Er, and Lu)

    NASA Astrophysics Data System (ADS)

    Horibe, Y.; Chae, S. C.; Lee, N.; Cheong, S.-W.

    2011-03-01

    Hexagonal RMn O3 (R=rare earths) exhibits a unique improper ferroelectricity induced by structural trimerization. Intriguing domain pattern associated with ferroelectricity and trimerization, so-called ``cloverleaf'' domain pattern, has been reported in YMn O3 In this talk, we will report the domain structures in a series of RMn O3 with different rare earth elements, obtained from the results of our transmission electron microscopy. Characteristic cloverleaf domain patterns are clearly observed in RMn O3 (R = Ho, Er, and Lu). The results imply that the cloverleaf domain pattern is a common domain feature in the hexagonal manganites.

  3. Hydrothermal synthesis and luminescent properties of LuBO{sub 3}:Tb{sup 3+} microflowers

    SciTech Connect

    Yang Jun; Zhang Cuimiao; Wang Lili; Hou Zhiyao; Huang Shanshan; Lian Hongzhou; Lin Jun

    2008-10-15

    Hexagonal vaterite-type LuBO{sub 3}:Tb{sup 3+} microflower-like phosphors have been successfully prepared by an efficient surfactant- and template-free hydrothermal process directly without further sintering treatment. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) spectrometry, transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED), photoluminescence (PL) and cathodoluminescence (CL) spectra as well as kinetic decays were used to characterize the samples. The as-obtained phosphor samples present flowerlike agglomerates composed of nanoflakes with thickness of 40 nm and high crystallinity in spite of the moderate reaction temperature of 200 deg. C. The reaction mechanism has been considered as a dissolution/precipitation mechanism; the self-assembly evolution process has been proposed on homocentric layer-by-layer growth style. Under ultraviolet excitation into the 4f{sup 8}{yields}4f{sup 7}5d transition of Tb{sup 3+} at 248 nm (or 288 nm) and low-voltage electron beam excitation, LuBO{sub 3}:Tb{sup 3+} samples show the characteristic green emission of Tb{sup 3+} corresponding to {sup 5}D{sub 4}{yields}{sup 7}F{sub 6,5,4,3} transitions with the {sup 5}D{sub 4}{yields}{sup 7}F{sub 5} transition (542 nm) being the most prominent group, which have potential applications in fluorescent lamps and field emission displays. - Graphical abstract: Hexagonal vaterite-type LuBO{sub 3}:Tb{sup 3+} microflower-like phosphors have been successfully prepared by a simple and mild hydrothermal process directly. The reaction mechanism has been considered as the dissolution/precipitation mechanism; the self-assembly evolution process has been proposed on homocentric layer-by-layer growth style. The luminescent properties of the as-obtained LuBO{sub 3}:Tb{sup 3+} samples have

  4. Charge Order in LuFe2O4: Antiferroelectric Ground State and Coupling to Magnetism

    SciTech Connect

    Angst, Manuel; Hermann, Raphael P.; Christianson, Andrew D; Lumsden, Mark D; Lee, C; Whangbo, M.-H.; Kim, J.-W.; Ryan, P J; Nagler, Stephen E; Tian, Wei; Jin, Rongying; Sales, Brian C; Mandrus, David

    2008-11-01

    X-ray scattering by multiferroic LuFe2O4 is reported. Below 320 K, superstructure reflections indicate an incommensurate charge order with propagation close to 1 3 1 3 3 2 . The corresponding charge configuration, also found by electronic structure calculations as most stable, contains polar Fe=O double layers with antiferroelectric stacking. Diffuse scattering at 360 K, with 1 3 1 3 0 propagation, indicates ferroelectric short-range correlations between neighboring double layers. The temperature dependence of the incommensuration indicates that charge order and magnetism are coupled.

  5. Direct band gaps in multiferroic h-LuFeO{sub 3}

    SciTech Connect

    Holinsworth, B. S.; Mazumdar, D.; Musfeldt, J. L.; Brooks, C. M.; Mundy, J. A.; Das, H.; Fennie, C. J.; Cherian, J. G.; McGill, S. A.; Schlom, D. G.

    2015-02-23

    We measured the optical properties of epitaxial thin films of the metastable hexagonal polymorph of LuFeO{sub 3} by absorption spectroscopy, magnetic circular dichroism, and photoconductivity. Comparison with complementary electronic structure calculations reveals a 1.1 eV direct gap involving hybridized Fe 3d{sub z{sup 2}}+O 2p{sub z}→Fe d excitations at the Γ and A points, with a higher energy direct gap at 2.0 eV. Both charge gaps nicely overlap the solar spectrum.

  6. Lu{sub 2}O{sub 3}:Eu{sup 3+} glass ceramic films: Synthesis, structural and spectroscopic studies

    SciTech Connect

    Carrera Jota, M.L.; García Murillo, A.; Morales Ramírez, A. de J.; Rosa Cruz, E. de la; Kassiba, Abdelhadi

    2014-03-01

    Graphical abstract: - Highlights: • Lu{sub 2}O{sub 3}:Eu{sup 3+}@SiO{sub 2} films were synthesized by sol–gel and by dip-coating technique. • Effects of incorporating PVP on structural properties were studied. • Effects of incorporating silica (SiO{sub 2}) luminescence characteristics were analyzed. • X-ray diffraction results showed that Lu{sub 2}O{sub 3}:Eu{sup 3+}@SiO{sub 2} crystallizes at 700 °C. • The 611 nm emission for the Lu:Si = 8:1 system presented an improvement. - Abstract: For the first time, transparent and crack free europium-doped lutetia silica sol–gel films were synthesized using the dip-coating technique on silica quartz substrates. In this study, we examined the effects of incorporating polyvinylpyrrolidone (PVP) and silica (SiO{sub 2}) into different precursor solutions for different Lu–Si molar ratios: 4:1, 6:1, 8:1 and 10:1. Different systems, such as Lu{sub 2}O{sub 3}:Eu{sup 3+}@SiO{sub 2} (using the above Lu:Si molar ratios), were synthesized by sol–gel and by dip-coating technique, employing acetylacetonate lutetium and tetraethylorthosilicate as Lu and Si precursors, in order to produce Lu{sub 2}O{sub 3}:Eu{sup 3+} (5 mol%)@SiO{sub 2} glass–ceramic films. The film microstructure was studied by microRaman spectroscopy (MRS) and X-ray diffraction (XRD) for different Lu:Si molar ratios on films annealed at 700 °C. X-ray diffraction results showed that the lutetium oxide cubic phase crystallizes in the silica matrix at 700 °C, and the crystallite size of Lu{sub 2}O{sub 3}:Eu{sup 3+}@SiO{sub 2} films varies from 5 nm to 17 nm according to the respective Lu:Si molar ratios. Opto-geometrical parameters determined by m-lines spectroscopy using a 632.5 nm He–Ne laser showed that the Eu{sup 3+} doped films heat-treated at 700 °C presented a thickness and density of 1.7 μm (8.8 g cm{sup −3}), 970 nm (9.2 g cm{sup −3}), 1 μm (9.3 g cm{sup −3}) and 1.3 μm (9.25 g cm{sup −3}) for the Lu:Si = 4:1, 6:1, 8:1 and 10

  7. Evaluation of (177)Lu-CHX-A''-DTPA-Bevacizumab as a radioimmunotherapy agent targeting VEGF expressing cancers.

    PubMed

    Kameswaran, Mythili; Pandey, Usha; Gamre, Naresh; Vimalnath, K V; Sarma, Haladhar Dev; Dash, Ashutosh

    2016-08-01

    This study aimed at the preparation and evaluation of (177)Lu-CHX-A''-DTPA-Bevacizumab for targeting VEGF over-expressing cancers. Bevacizumab conjugated to p-NCS-Bn-CHX-A''-DTPA was radiolabeled with (177)Lu. The radioimmunoconjugate characterized by SE-HPLC exhibited radiochemical purity of 98.0±0.6%. In vitro stability was retained upto 4 days at 37°C. In vitro cell binding studies showed good uptake by VEGF expressing U937 tumor cells. Biodistribution studies in melanoma model showed significant uptake and retention of (177)Lu-CHX-A''-DTPA-Bevacizumab in tumor with reduction in uptake in presence of cold Bevacizumab confirming its specificity to VEGF. PMID:27258216

  8. Lu1-xI3:Cex--A Scintillator for gamma ray spectroscopy and time-of-flight PET

    DOEpatents

    Shah, Kanai S.

    2009-03-17

    The present invention concerns very fast scintillator materials comprising lutetium iodide doped with Cerium Lu.sub.1-xI.sub.3:Ce.sub.x; LuI.sub.3:Ce). The LuI.sub.3 scintillator material has surprisingly good characteristics including high light output, high gamma ray stopping efficiency, fast response, low cost, good proportionality, and minimal afterglow that the material is useful for gamma ray spectroscopy, medical imaging, nuclear and high energy physics research, diffraction, non-destructive testing, nuclear treaty verification and safeguards, and geological exploration. The timing resolution of the scintillators of the present invention provide compositions capable of resolving the position of an annihilation event within a portion of a human body cross-section.

  9. Evaluation of (177)Lu-CHX-A''-DTPA-Bevacizumab as a radioimmunotherapy agent targeting VEGF expressing cancers.

    PubMed

    Kameswaran, Mythili; Pandey, Usha; Gamre, Naresh; Vimalnath, K V; Sarma, Haladhar Dev; Dash, Ashutosh

    2016-08-01

    This study aimed at the preparation and evaluation of (177)Lu-CHX-A''-DTPA-Bevacizumab for targeting VEGF over-expressing cancers. Bevacizumab conjugated to p-NCS-Bn-CHX-A''-DTPA was radiolabeled with (177)Lu. The radioimmunoconjugate characterized by SE-HPLC exhibited radiochemical purity of 98.0±0.6%. In vitro stability was retained upto 4 days at 37°C. In vitro cell binding studies showed good uptake by VEGF expressing U937 tumor cells. Biodistribution studies in melanoma model showed significant uptake and retention of (177)Lu-CHX-A''-DTPA-Bevacizumab in tumor with reduction in uptake in presence of cold Bevacizumab confirming its specificity to VEGF.

  10. Reconstruction of the polar interface between hexagonal LuFeO3 and intergrown Fe3O4 nanolayers

    PubMed Central

    Akbashev, A. R.; Roddatis, V. V.; Vasiliev, A. L.; Lopatin, S.; Amelichev, V. A.; Kaul, A. R.

    2012-01-01

    We report the observation of an unusual phase assembly behavior during the growth of hexagonal LuFeO3 thin films which resulted in the formation of epitaxial Fe3O4 nanolayers. The magnetite layers were up to 5 nm thick and grew under the conditions at which Fe2O3 is thermodynamically stable. These Fe3O4 nanolayers act as buffer layers promoting a highly epitaxial growth of the hexagonal LuFeO3 thin film up to 150 nm thick. Using scanning transmission electron microscopy, we show that the interface between (001) LuFeO3 and (111) Fe3O4 can be reconstructed in two ways depending on the sequence in which these compounds grow on each other. We suggest the polarity of the interface is the reason behind the observed interface reconstruction and epitaxial stabilization of magnetite. PMID:22993697

  11. Lu-Hf and Sm-Nd Isotopic Studies of Shergottites and Nakhlites: Implications for Martian Mantle Sources

    NASA Technical Reports Server (NTRS)

    Debaille, V.; Yin, Q.-Z.; Brandon, A. D.; Jacobsen, B.; Treiman, A. H.

    2007-01-01

    We present a new Lu-Hf and Sm-Nd isotope systematics study of four enriched shergottites (Zagami, Shergotty, NWA856 and Los Angeles), and three nakhlites (Nakhla, MIL03346 and Yamato 000593) in order to further understand processes occurring during the early differentiation of Mars and the crystallization of its magma ocean. Two fractions of the terrestrial petrological analogue of nakhlites, the Archaean Theo's flow (Ontario, Canada) were also measured. The coupling of Nd and Hf isotopes provide direct insights on the mineralogy of the melt sources. In contrast to Sm/Nd, Lu/Hf ratios can be very large in minerals such as garnet. Selective partial melting of garnet bearing mantle sources can therefore lead to characteristic Lu/Hf signatures that can be recognized with Hf-176/Hf-177Hf ratios.

  12. Athermal distributed Brillouin sensors utilizing all-glass optical fibers fabricated from rare earth garnets: LuAG

    NASA Astrophysics Data System (ADS)

    Dragic, P. D.; Pamato, M. G.; Iordache, V.; Bass, J. D.; Kucera, C. J.; Jones, M.; Hawkins, T. W.; Ballato, J.

    2016-01-01

    An all-glass optical fiber derived from single-crystal LuAG is investigated for its potential use in athermal Brillouin distributed strain sensors. Such sensor systems are comprised of fiber whose Brillouin frequency shift is independent of temperature, but not independent of strain. Bulk Brillouin spectroscopy measurements on the precursor LuAG crystal are performed to gain insight into the crystal-to-glass transition. Results suggest that both the mass density and acoustic velocity are reduced relative to the crystal phase, in common with the other rare earth aluminosilicates. Advantages of the LuAG derived fiber over other rare earth garnet-derived fibers for the sensing application are a stronger strain response and larger Brilloun gain with narrower Brillouin spectral width.

  13. New microarchitectures of (Er,Yb):Lu2O3 nanocrystals embedded in PMMA: synthesis, structural characterization, and luminescent properties

    NASA Astrophysics Data System (ADS)

    Galceran, Montserrat; Pujol, Maria Cinta; Carvajal, Joan Josep; Mateos, Xavier; Formentín, Pilar; Pallarès, Josep; Marsal, Lluis Francesc; Park, Kyung Ho; Rotermund, Fabian; Kim, Kihong; Aguiló, Magdalena; Díaz, Francesc

    2013-09-01

    We report the formation of two-dimensional disordered arrays of poly(methyl)methacrylate (PMMA) microcolumns with embedded single size distribution of Lu0.990Er0.520Yb0.490 nanocrystals, (Er,Yb):Lu2O3, using a disordered porous silicon template. The cubic (Er,Yb):Lu2O3 nanocrystals, which crystallize into the cubic system with [Equation not available: see fulltext.] space group, were synthesized using the modified Pechini method. Electronic microscopic techniques were used to study the distribution of the nanocrystals in the PMMA columns. Cathodoluminescence was used to observe the visible luminescence of the particles. Red emission attributed to 4 F9/2 → 4I15/2 erbium transition is predominant in these new composites.

  14. Serafeddin Sabuncuoğlu, the author of the earliest pediatric surgical atlas: Cerrahiye-i Ilhaniye.

    PubMed

    Büyükünal, S N; Sari, N

    1991-10-01

    The author of one of the earliest surgical books was Serafeddin Sabuncuoğlu, who was born in one of the ancient cities of Central Anatolia. In 1465, he wrote a surgical book in Turkish. The aim of this study was to investigate the details of this book and compare it with the old classics. It was observed that the book of Sabuncuoğlu did not contain only pictures or miniatures of pediatric surgical procedures, but there were many important and major new contributions to the surgical literature originally described by Sabuncuoğlu himself. He based his contributions and techniques on formerly designed and described procedures, moreover, developing and nourishing pediatric surgical culture of that era. Thus a combination of Greek, Roman, Arabic, and Turkish pediatric surgery combined extraordinarily and influenced the development of European pediatric surgery. PMID:1779321

  15. Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

    SciTech Connect

    Frost, Sophia; Frayo, Shani; Miller, Brian W.; Orozco, Johnnie J.; Booth, Garrett C.; Hylarides, Mark; Lin, Yukang; Green, Damian J.; Gopal, Ajay K.; Pagel, John M.; Back, Tom; Fisher, Darrell R.; Press, Oliver W.

    2015-03-01

    Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice.

  16. Development and biological studies of ¹⁷⁷Lu-DOTA-rituximab for the treatment of Non-Hodgkin's lymphoma.

    PubMed

    Massicano, Adriana V F; Pujatti, Priscilla B; Alcarde, Lais F; Suzuki, Miriam F; Spencer, Patrick J; Araújo, Elaine B

    2016-01-01

    The optimization of DOTA-NHS-ester conjugation to Rituximab using different Ab:DOTA molar ratios (1:10, 1:20, 1:50 and 1:100) was studied. High radiochemical yield, in vitro stability and immunoreactive fraction were obtained for the Rituximab conjugated at 1:50 molar ratio, resulting in the incorporation of an average number of 4.9 ± 1.1 DOTA per Rituximab molecule. Labeling with 177Lu was performed in high specific activity with great in vitro stability. Biodistribution in healthy and xenographed mice showed tumor uptake and high in vivo stability as evidenced by low uptake in bone. The properties of 177Lu-DOTA-Rituximab prepared from DOTA-NHS-ester suggest the potential for the application of the 177Lu-labeled antibody in preliminary clinical studies.

  17. The adsorption-controlled growth of LuFe{sub 2}O{sub 4} by molecular-beam epitaxy

    SciTech Connect

    Brooks, Charles M.; Misra, Rajiv; Schiffer, Peter; Mundy, Julia A.; Zhang Lei, A.; Liu Zikui; Holinsworth, Brian S.; O'Neal, Kenneth R.; Musfeldt, Janice L.; Heeg, Tassilo; Zander, Willi; Schubert, J.; Muller, David A.; Schlom, Darrell G.

    2012-09-24

    We report the growth of single-phase (0001)-oriented epitaxial films of the purported electronically driven multiferroic, LuFe{sub 2}O{sub 4}, on (111) MgAl{sub 2}O{sub 4}, (111) MgO, and (0001) 6H-SiC substrates. Film stoichiometry was regulated using an adsorption-controlled growth process by depositing LuFe{sub 2}O{sub 4} in an iron-rich environment at pressures and temperatures where excess iron desorbs from the film surface during growth. Scanning transmission electron microscopy reveals reaction-free film-substrate interfaces. The magnetization increases rapidly below 240 K, consistent with the paramagnetic-to-ferrimagnetic phase transition of bulk LuFe{sub 2}O{sub 4}. In addition to the {approx}0.35 eV indirect band gap, optical spectroscopy reveals a 3.4 eV direct band gap at the gamma point.

  18. Synthesis and comparative biological evaluation of bifunctional ligands for radiotherapy applications of (90)Y and (177)Lu.

    PubMed

    Chong, Hyun-Soon; Sun, Xiang; Chen, Yunwei; Sin, Inseok; Kang, Chi Soo; Lewis, Michael R; Liu, Dijie; Ruthengael, Varyanna C; Zhong, Yongliang; Wu, Ningjie; Song, Hyun A

    2015-03-01

    Zevalin® is an antibody-drug conjugate radiolabeled with a cytotoxic radioisotope ((90)Y) that was approved for radioimmunotherapy (RIT) of B-cell non-Hodgkin's lymphoma. A bifunctional ligand that displays favorable complexation kinetics and in vivo stability is required for effective RIT. New bifunctional ligands 3p-C-DE4TA and 3p-C-NE3TA for potential use in RIT were efficiently prepared by the synthetic route based on regiospecific ring opening of aziridinium ions with prealkylated triaza- or tetraaza-backboned macrocycles. The new bifunctional ligands 3p-C-DE4TA and 3p-C-NE3TA along with the known bimodal ligands 3p-C-NETA and 3p-C-DEPA were comparatively evaluated for potential use in targeted radiotherapy using β-emitting radionuclides (90)Y and (177)Lu. The bifunctional ligands were evaluated for radiolabeling kinetics with (90)Y and (177)Lu, and the corresponding (90)Y or (177)Lu-radiolabeled complexes were studied for in vitro stability in human serum and in vivo biodistribution in mice. The results of the comparative complexation kinetic and stability studies indicate that size of macrocyclic cavity, ligand denticity, and bimodality of donor groups have a substantial impact on complexation of the bifunctional ligands with the radiolanthanides. The new promising bifunctional chelates in the DE4TA and NE3TA series were rapid in binding (90)Y and (177)Lu, and the corresponding (90)Y- and (177)Lu-radiolabeled complexes remained inert in human serum or in mice. The in vitro and in vivo data show that 3p-C-DE4TA and 3p-C-NE3TA are promising bifunctional ligands for targeted radiotherapy applications of (90)Y and (177)Lu.

  19. REE and Lu-Hf systematics of zircons from rapakivi granites and associated rocks of supercontinent Nuna (Columbia)

    NASA Astrophysics Data System (ADS)

    Ronkin, Yu. L.; Gerdes, A.; Maslov, A. V.

    2015-03-01

    The last of the rifting events at 1.37-1.45 Ga that is considered to have led to the final breakup of Nuna was recorded in most of its building blocks (Laurentia, Baltica, and Siberian craton). At the type locality for the Riphean on the western slope of the South Urals, this event was recognized as the Mashak igneous event (˜1380 Ma) and can be classified as a LIP based on the volumes of magma generated (total igneous volumes >0.05 × 106 km3). The emplacement of large volumes of A-type granitic plutons in Laurentia and northwestern Baltica (in the present coordinates) was almost synchronous with this event. In the South Urals, within the Bashkirian meganticlinorium, the processes of granite generation and emplacement during this time took place on a much smaller scale. Anorogenic granites of this region are represented by rapakivi granites of the Berdyaush massif. The first REE and Lu-Hf isotope data for zircons from rapakivi granites and associated rocks of the Berdyaush massif reveal almost identical Lu-Hf isotope ages (˜1383 Ma) of rapakivi granites, quartz syenitic diorites, and nepheline syenites. It was shown that these rocks, which were emplaced into the heterogeneous Proterozoic crust between the Early and Middle Riphean, have the Hf isotopic compositions and Lu-Hf model ages reflecting the contribution from crustal sources with ages of 2013-2219 Ma, whereas the associated gabbros indicate derivation from a source with the Lu-Hf ages of 1658 ± 1685 Ma and moderately depleted ɛHf(1383) of (4.1 ± 0.7-4.9 ± 0.6). The REE characteristics (ΣREE, Eu/Eu*, Ce/Ce*, Pr/Pr*, La/Lu) and Lu-Hf isotope systematics of zircons can be used to constrain the history and genetic evolution of supercontinents, e.g., supercontinent Nuna (Columbia) in particular.

  20. First principle study of AlX (X=3d, 4d, 5d elements and Lu) dimer.

    PubMed

    Ouyang, Yifang; Wang, Jianchuan; Hou, Yuhua; Zhong, Xiaping; Du, Yong; Feng, Yuanping

    2008-02-21

    The ground state equilibrium bond length, harmonic vibrational frequency, and dissociation energy of AlX (X=3d,4d,5d elements and Lu) dimers are investigated by density functional method B3LYP. The present results are in good agreement with the available experimental and other theoretical values except the dissociation energy of AlCr. The present calculations show that the late transition metal can combine strongly with aluminum compared with the former transition metal. The present calculation also indicates that it is more reasonable to replace La with Lu in the Periodic Table and that the bonding strengths of zinc, cadmium, and mercury with aluminum are very weak.

  1. The pseudogap and anisotropic thermal expansion in RMn(4)Al(8) (R = La,Y,Lu and Sc).

    PubMed

    Muro, Y; Nakamura, H; Kohara, T

    2006-04-26

    The temperature dependence of the magnetic susceptibility shows a broad maximum at ∼550 and 630 K for LuMn(4)Al(8) and ScMn(4)Al(8), respectively, which can be interpreted as due to the presence of a pseudogap in the effective bands as in LaMn(4)Al(8) and YMn(4)Al(8). The anisotropic thermal expansion observed for RMn(4)Al(8) (R = La, Y, Lu and Sc) and the sensitive volume dependence of the gap width throughout the RMn(4)Al(8) system suggest dominant magnetic coupling in Mn spin chains along the c axis.

  2. Lifetime measurements of normal deformed states in {sub 71}{sup 165}Lu

    SciTech Connect

    Andgren, K.; Podolyak, Zs.; Gelletly, W.; Walker, P. M.; Wheldon, C.; Dewald, A.; Fitzler, A.; Moeller, O.; Pissulla, T.; Xu, F.R.; Algora, A.; Axiotis, M.; Angelis, G. de; Farnea, E.; Gadea, A.; Marginean, N.; Martinez, T.; Rusu, C.; Bazzacco, D.; Lunardi, S.

    2005-01-01

    Picosecond lifetimes of medium spin states in {sup 165}Lu were measured for the first time. The reaction used to populate the nucleus of interest was {sup 139}La({sup 30}Si,4n){sup 165}Lu at a beam energy of 135 MeV. The beam was provided by the XTU-tandem accelerator of Laboratori Nazionali di Legnaro, Italy. By using the differential decay curve method, lifetimes of 19 states in four different rotational bands were obtained. Therefrom the B(E2) values and the transitional quadrupole moments were deduced. The obtained Q{sub t} for the different bands are compared with total Routhian surface (TRS) calculations and particle-rotor-model calculations. The TRS calculations predict different axial symmetric shapes for the bands built on the 9/2{sup -}[514], 9/2{sup +}[404], and 1/2{sup -}[541] configurations, with a {gamma} softness for the 9/2{sup -}[514] configuration. This band has also been studied using the particle-rotor model, the results of which, however, are consistent with a triaxial shape with a {gamma} value of -15 degrees.

  3. Importance of the Lu-Hf isotopic system in studies of planetary chronology and chemical evolution

    NASA Technical Reports Server (NTRS)

    Patchett, P. J.

    1983-01-01

    The Lu-176-Hf-176 isotope method and its applications in earth sciences are discussed with regard to planetary-evolution studies. From new data on basalts from oceanic islands, Hf-176/Hf-177 and Nd-143/Nd-144 are found to display a single linear isotopic variation in the suboceanic mantle, whereas considerable divergences occur in Hf-176/Hf-177-Sr-87/Sr-86 and Nd-143/Nd-144-Sr87/Sr-86 diagrams. With the acquisition of further Hf-Sr-Nd isotopic data, these discordant Sr-87/Sr-86 relationships may allow a distinction between processes such as mantle metasomatism, influence of sea-water altered material in the magma source, or recycling of sediments into the mantle. The best quality Hf isotope data are obtained from granitoid or zircons, and are most suitable for studying ancient terrestrial Hf isotopic variations. Lu-Hf is shown to be a viable method for dating ancient terrestrial and extraterrestrial samples, but is unlikely to find wide application in pure chronological studies because it offers little advantage over existing methods.

  4. Novel High Efficiency Microcolumnar LuI3:Ce for Hard X-ray Imaging

    NASA Astrophysics Data System (ADS)

    Marton, Z.; Nagarkar, Vivek V.; Miller, Stuart R.; Brecher, Charles; Bhandari, Harish B.; Kenesei, Peter; Ross, Stephen K.; Almer, Jonathan D.; Singh, Bipin

    2014-03-01

    We have developed a structured scintillator using a vacuum deposition technique that is suitable for manufacturing large area scintillators in a microcolumnar form. While providing high absorption efficiency, it also allows great temporal and spatial resolution X-ray imaging. Microcolumnar films of extremely fast and bright cerium-doped lutetium iodide (LuI3:Ce) scintillator were synthesized. It has high density (~5.6 g/cm3), high effective atomic number (59.7), bright green emission (540 nm range, well matched to commercial optics and CCD sensors), light yield exceeding 115,000 ph/MeV, and rapid, afterglow-free decay (~28 ns). This new scintillator could resolve the 153 ns bunch structure of the Advanced Photon Source (APS) at Argonne National Laboratory (ANL). Due to the fast, afterglow-free decay, and high efficiency of LuI3:Ce, during the experiments performed at the 1-ID hard X-ray beamline at the APS, single 65 keV X-ray photons could be resolved with high signal-to-noise ratio and with temporal resolution better than 20ns. In the future, it will enable a wide range of hard X-ray (20 keV to 100 keV) imaging and/or high frame-rate applications such as dynamic studies of the structural and electrochemical properties of batteries using microtomographic X-ray imaging, internal corrosion in fuel cells, and time-resolved muscle diffraction experiments.

  5. A Flexible CUDA LU-based Solver for Small, Batched Linear Systems

    SciTech Connect

    Tumeo, Antonino; Gawande, Nitin A.; Villa, Oreste

    2014-06-09

    This chapter presents the implementation of a batched CUDA solver based on LU factorization for small linear systems. This solver may be used in applications such as reactive flow transport models, which apply the Newton-Raphson technique to linearize and iteratively solve the sets of non linear equations that represent the reactions for ten of thousands to millions of physical locations. The implementation exploits somewhat counterintuitive GPGPU programming techniques: it assigns the solution of a matrix (representing a system) to a single CUDA thread, does not exploit shared memory and employs dynamic memory allocation on the GPUs. These techniques enable our implementation to simultaneously solve sets of systems with over 100 equations and to employ LU decomposition with complete pivoting, providing the higher numerical accuracy required by certain applications. Other currently available solutions for batched linear solvers are limited by size and only support partial pivoting, although they may result faster in certain conditions. We discuss the code of our implementation and present a comparison with the other implementations, discussing the various tradeoffs in terms of performance and flexibility. This work will enable developers that need batched linear solvers to choose whichever implementation is more appropriate to the features and the requirements of their applications, and even to implement dynamic switching approaches that can choose the best implementation depending on the input data.

  6. Thermo-optic properties of Yb:Lu2O3 single crystals

    NASA Astrophysics Data System (ADS)

    Loiko, P. A.; Yumashev, K. V.; Schödel, R.; Peltz, M.; Liebald, C.; Mateos, X.; Deppe, B.; Kränkel, C.

    2015-09-01

    A detailed study of thermo-optic properties of 1.5 at.% Yb:Lu2O3 single crystal is performed. Thermo-optic dispersion formulas are derived for d n/d T coefficient and thermal coefficient of the optical path. At the wavelength of 1.03 μm, d n/d T = 5.8 × 10-6 K-1. High-precision temperature-dependent measurements of the thermal expansion coefficient α are performed. At the room temperature (RT), α = 5.880 ± 0.014 × 10-6 K-1. Temperature dependence of the bandgap is analyzed, yielding RT value of E g = 5.15 eV and d E g/d T = -3.7 × 10-4 eV/K. Sensitivity factor of the thermal lens is calculated for a diode-pumped Yb:Lu2O3 crystal versus the pump spot radius and crystal temperature.

  7. Transparent Lu 2 O 3 :Eu ceramics by sinter and HIP optimization

    NASA Astrophysics Data System (ADS)

    Seeley, Z. M.; Kuntz, J. D.; Cherepy, N. J.; Payne, S. A.

    2011-09-01

    Evolution of porosity and microstructure was observed during densification of lutetium oxide ceramics doped with europium (Lu 2O 3:Eu) fabricated via vacuum sintering and hot isostatic pressing (HIP'ing). Nano-scale starting powder was uniaxially pressed and sintered under high vacuum at temperatures between 1575 and 1850 °C to obtain densities ranging between 94% and 99%, respectively. Sintered compacts were then subjected to 200 MPa argon gas at 1850 °C to reach full density. Vacuum sintering above 1650 °C led to rapid grain growth prior to densification, rendering the pores immobile. Sintering between 1600 and 1650 °C resulted in closed porosity yet a fine grain size to allow the pores to remain mobile during the subsequent HIP'ing step, resulting in a fully-dense highly transparent ceramic without the need for subsequent air anneal. Light yield performance was measured and Lu 2O 3:Eu showed ˜4 times higher light yield than commercially used scintillating glass indicating that this material has the potential to improve the performance of high energy radiography devices.

  8. Magnetization dynamics and frustration in the multiferroic double perovskite Lu2MnCoO6

    DOE PAGES

    Zapf, Vivien S.; Ueland, B. G.; Laver, Mark; Lonsky, Martin; Pohlit, Merlin; Muller, Jens; Lancaster, Tom; Moller, Johannes S.; Blundell, Stephen J.; Singleton, John; et al

    2016-04-29

    Here, we investigate the magnetic ordering and the magnetization dynamics (from kHz to THz time scales) of the double perovskite Lu2MnCoO6 using elastic neutron diffraction, muon spin relaxation, and micro-Hall magnetization measurements. This compound is known to be a type II multiferroic with the interesting feature that a ferromagneticlike magnetization hysteresis loop couples to an equally hysteretic electric polarization in the bulk of the material despite a zero-field magnetic ordering of the type ↑↑↓↓ along Co-Mn spin chains. Here we explore the unusual dynamics of this compound and find extremely strong fluctuations, consistent with the axial next-nearest-neighbor Ising (ANNNI) modelmore » for frustrated spin chains. We identify three temperature scales in Lu2MnCoO6 corresponding to the onset of highly fluctuating long-range order below TN = 50±3 K identified from neutron scattering, the onset of magnetic and electric hysteresis, with change in kHz magnetic and electric dynamics below a 30 K temperature scale, and partial freezing of ~MHz spin fluctuations in the muon spin relaxation data below 12 ± 3 K. Our results provide a framework for understanding the multiferroic behavior of this compound and its hysteresis and dynamics.« less

  9. Uncertainty propagation for SPECT/CT-based renal dosimetry in 177Lu peptide receptor radionuclide therapy

    NASA Astrophysics Data System (ADS)

    Gustafsson, Johan; Brolin, Gustav; Cox, Maurice; Ljungberg, Michael; Johansson, Lena; Sjögreen Gleisner, Katarina

    2015-11-01

    A computer model of a patient-specific clinical 177Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability of renal absorbed dose and biologically effective dose (BED) estimates. As patient models, three anthropomorphic computer phantoms coupled to a pharmacokinetic model of 177Lu-DOTATATE are used. Aspects included in the dosimetry-process model are the gamma-camera calibration via measurement of the system sensitivity, selection of imaging time points, generation of mass-density maps from CT, SPECT imaging, volume-of-interest delineation, calculation of absorbed-dose rate via a combination of local energy deposition for electrons and Monte Carlo simulations of photons, curve fitting and integration to absorbed dose and BED. By introducing variabilities in these steps the combined uncertainty in the output quantity is determined. The importance of different sources of uncertainty is assessed by observing the decrease in standard deviation when removing a particular source. The obtained absorbed dose and BED standard deviations are approximately 6% and slightly higher if considering the root mean square error. The most important sources of variability are the compensation for partial volume effects via a recovery coefficient and the gamma-camera calibration via the system sensitivity.

  10. Zircon Lu-Hf systematics: Evidence for the episodic development of Archaean greenstone belts

    NASA Technical Reports Server (NTRS)

    Smith, P. E.; Tatsumoto, M.; Farquhar, R. M.

    1986-01-01

    A combined U-Th-Pb and Lu-Hf isotopic study of zircons was undertaken in order to determine the provenance and age of an Archean granite-greenstone terrain and to test the detailed application of the Lu-Hf system in various Archean zircons. The eastern Wawa subprovince of the Superior province consists of the low grade Michipicoten and Gamitagama greenstone belts and the granitic terrain. The Hf isotopic data indicate that the typical lithological features of a greenstone belt cycle could be accommodated in a crustal growth model that involved decreasing depth of melting in three isotopically distinct reservoirs: mantle, lower crust and upper crust. The model age of the sources given by the intersection of the lower crustal curve with the bulk earth evolution curve is about 2900 My, in good agreement with the zircon U-Pb basement age. This linear array also has a similar intersection age to that of Proterozoic carbonatite complexes. The general convergence of the other reservoir vectors around this age suggests that mantle depletion, crustal extraction and intracrustal differentiation were all part of the same episodic event. It is also apparent that recycling of older basement was important in the formation of many of the later greenstone belt rocks.

  11. Anisotropy of the Vortex Magnetic Field Distribution in LuNi2B2

    NASA Astrophysics Data System (ADS)

    Eskildsen, M. R.; Debeer-Schmitt, L.; Rovira, K.; Jenkins, N.; Dewhurst, C. D.; Bud'Ko, S. L.; Canfield, P. C.

    2008-03-01

    It is well known that the vortex lattice (VL) symmetry and orientation in type-II superconductors is very sensitive to any anisotropy within the screening current plane. A classic example is the sequence of transitions from hexagonal to rhombic to square symmetry, which was first observed in the borocarbide superconductors and explained by a Fermi surface anisotropy coupled with the non-local electrodynamics responsible for vortex-vortex interactions. Recently, however, this is mounting experimental evidence for a strong gap anisotropy and possible point nodes in the basal plane of these materials. Here we report on small-angle neutron scattering studies of the VL in a carefully annealed, high quality LuNi2B2C single crystal, which permitted us to measure the VL form factor for a large number of reflections. These measurements allow a reconstruction of the real space profile of the magnetic field around the vortices, reflecting the basal plane anisotropy of the screening currents in LuNi2B2C. The results will be compared to predictions for both Fermi surface and gap anisotropies, and will serve as a valuable reference for more complicated compounds as e.g. Sr2RuO4, heavy fermions and high-Tc's.

  12. Syn-collisional transform faulting of the Tan-Lu fault zone, East China

    NASA Astrophysics Data System (ADS)

    Zhu, Guang; Liu, Guo Sheng; Niu, Man Lan; Xie, Cheng Long; Wang, Yong Sheng; Xiang, Biwei

    2009-02-01

    Origin of the continental-scale Tan-Lu fault zone (TLFZ), East China, remains controversial. About 550 km sinistral offset of the Dabie orogenic belt (DOB) and Sulu orogenic belt (SOB) is shown along the NE-NNE-striking TLFZ. Syn-collisional, sinistral ductile shear belts in the TLFZ have been identified. Thirteen phengite bulk separates from the mylonites were dated by the 40Ar/39Ar method. They gave cooling ages of the 198-181 Ma for the shear belts along the eastern margin of the DOB and 221-210 Ma from the western margin of the SOB. Distribution of the foreland basin deposits suggests that sinistral offset of the DOB and SOB by the TLFZ took place prior to deposition of the Upper Triassic strata. The marginal structures around the DOB and SOB support syn-collisional faulting, and indicate anticlockwise rotation of the DOB during the displacement. The folding and thrust faulting related to crustal subduction, coeval with the Tan-Lu faulting, is older than the foreland basin deposition related to the orogenic exhumation. Several lines of evidence demonstrate that the TLFZ was developed as a syn-collisional transform fault during latest Middle to earliest Late Triassic time when the DOB and SOB experienced crustal subduction of the South China Block (SCB). Eastward increase of the crustal subduction rates is believed to be responsible for the sinistral transform faulting.

  13. Stellar Neutron Capture Cross Sections of the Lu and Hf Isotopes

    SciTech Connect

    Wisshak, K.; Voss, F.; Kaeppeler, F.; Kazakov, L.; Krticka, M.

    2005-05-24

    The neutron capture cross sections of 175,176Lu and 176,177,178,179,180Hf have been measured in the energy range from 3 to 225 keV at the Karlsruhe 3.7 MV Van de Graaff accelerator relative to the gold standard. Neutrons were produced by the 7Li(p,n)7Be reaction and capture events were detected by the Karlsruhe 4{pi}BaF2 detector. The cross section ratios could be determined with uncertainties between 0.9 and 1.8% about a factor of five more accurate than previous data. A strong population of isomeric states was found in neutron capture of the Hf isotopes, which are only partially explained by CASINO/GEANT simulations based on the known level schemes.Maxwellian averaged neutron capture cross sections were calculated for thermal energies between kT = 8 keV and 100 keV. Severe differences up to40% were found to the data of a recent evaluation based on existing experimental results. The new data allow for a much more reliable analysis of the important branching in the s-process synthesis path at 176Lu which can be interpreted as an s-process thermometer.

  14. Realistic multi-cellular dosimetry for 177Lu-labelled antibodies: model and application

    NASA Astrophysics Data System (ADS)

    Marcatili, S.; Pichard, A.; Courteau, A.; Ladjohounlou, R.; Navarro-Teulon, I.; Repetto-Llamazares, A.; Heyerdahl, H.; Dahle, J.; Pouget, J. P.; Bardiès, M.

    2016-10-01

    Current preclinical dosimetric models often fail to take account of the complex nature of absorbed dose distribution typical of in vitro clonogenic experiments in targeted radionuclide therapy. For this reason, clonogenic survival is often expressed as a function of added activity rather than the absorbed dose delivered to cells/cell nuclei. We designed a multi-cellular dosimetry model that takes into account the realistic distributions of cells in the Petri dish, for the establishment of survival curves as a function of the absorbed dose. General-purpose software tools were used for the generation of realistic, randomised 3D cell culture geometries based on experimentally determined parameters (cell size, cell density, cluster density, average cluster size, cell cumulated activity). A mixture of Monte Carlo and analytical approaches was implemented in order to achieve as accurate as possible results while reducing calculation time. The model was here applied to clonogenic survival experiments carried out to compare the efficacy of Betalutin®, a novel 177Lu-labelled antibody radionuclide conjugate for the treatment of non-Hodgkin lymphoma, to that of 177Lu-labelled CD20-specific (rituximab) and non-specific antibodies (Erbitux) on lymphocyte B cells. The 3D cellular model developed allowed a better understanding of the radiative and non-radiative processes associated with cellular death. Our approach is generic and can also be applied to other radiopharmaceuticals and cell distributions.

  15. Cross sections for fast-neutron interaction with Lu, Tb, and Ta isotopes

    SciTech Connect

    Dzysiuk, N.; Kadenko, I.; Yermolenko, R.; Koning, A. J.

    2010-01-15

    The cross sections for (n,x) reactions with Lu, Tb, and Ta isotopes were measured at (d,t) neutron energies around 14 MeV with the activation technique using metal foils of natural composition. Additionally, tantalum samples were irradiated with (d,d) neutrons and filtered neutron beams. To ensure an acceptable precision of the results all major sources of uncertainties were taken into account. Calculations of efficiency and correction factors were performed with the Monte Carlo technique. The cross section results obtained for the {sup 175}Lu(n,{alpha}){sup 172}Tm reaction at (d,t) neutron energies are reported for the first time. {sup 181}Ta(n,{gamma}){sup 182}Ta{sup m2} reaction cross sections were also measured for the first time at 1.9, 58.7, and 144.3 keV and at 2.85 MeV. The earlier evaluated cross section upper estimate for the nuclear reaction {sup 159}Tb(n,n{sup '}{alpha}){sup 155}Eu is reported in this article to be one order lower. Some other cross sections were obtained with higher precision. Theoretical calculations of excitation functions were performed with the TALYS-1.0 code and compared with the experimental cross section values.

  16. [Comparison of academic viewpoints between Yun Tie-qiao and Lu Yuan-lei].

    PubMed

    Yang, Zhi-qing; Bi, Li-juan; Yang, Xing-lin

    2010-07-01

    Both Yun Tie-qiao and Lu Yuan-lei are medical professionals coming from the literary field with versatile and in-depth knowledge and extensive experience in medical education and clinical practice, all closely related to modern TCM development. Yun, the elder, insisted on reforming TCM and was early to advocate the academic idea of amalgamating western and traditional Chinese medicine; while Lu, the younger, insisted on the idea of "scientizing TCM" and was the representative of amalgamating western and traditional Chinese medicine in the later stage. They shared many common viewpoints, including venerating Zhang Zhongjing, stressing exogenous cold pathogens, advocating reformation and amalgamation of western medicine and TCM and objecting to the abolishment of TCM. However, there were discrepancies between them, including the relationship between the Inner Canon and the Essay on Exogenous Cold Diseases, warm disease theory, pulse theory, titles of TCM diseases and Japanese Kampo medicine. A comparison of them and noting their valuable contributions will be beneficial for the promotion of the development of TCM. PMID:21122338

  17. Patterns of HIV prevalence among injecting drug users in the cross-border area of Lang Son Province, Vietnam, and Ning Ming County, Guangxi Province, China

    PubMed Central

    Des Jarlais, Don C; Johnston, Patrick; Friedmann, Patricia; Kling, Ryan; Liu, Wei; Ngu, Doan; Chen, Yi; Hoang, Tran V; Donghua, Meng; Van, Ly K; Tung, Nguyen D; Binh, Kieu T; Hammett, Theodore M

    2005-01-01

    Background To assess patterns of injecting drug use and HIV prevalence among injecting drug users (IDUs) in an international border area along a major heroin trans-shipment route. Methods Cross-sectional surveys of IDUs in 5 sites in Lang Son Province, Vietnam (n = 348) and 3 sites in Ning Ming County, Guangxi Province, China (n = 308). Respondents were recruited through peer referral ("snowball") methods in both countries, and also from officially recorded lists of IDUs in Vietnam. A risk behavior questionnaire was administered and HIV counseling and testing conducted. Results Participants in both countries were largely male, in their 20s, and unmarried. A majority of subjects in both countries were members of ethnic minority groups. There were strong geographic gradients for length of drug injecting and for HIV seroprevalence. Both mean years injecting and HIV seroprevalence declined from the Vietnamese site farthest from the border to the Chinese site farthest from the border. 10.6% of participants in China and 24.5% of participants in Vietnam reported crossing the international border in the 6 months prior to interview. Crossing the border by IDUs was associated with (1) distance from the border, (2) being a member of an ethnic minority group, and (3) being HIV seropositive among Chinese participants. Conclusion Reducing the international spread of HIV among IDUs will require programs at the global, regional, national, and "local cross border" levels. At the local cross border level, the programs should be coordinated on both sides of the border and on a sufficient scale that IDUs will be able to readily obtain clean injection equipment on the other side of the border as well as in their country of residence. PMID:16120225

  18. Lu-Hf Isotope Systematics of the Nuvvuagittuq Supracrustal Belt (Québec, Canada)

    NASA Astrophysics Data System (ADS)

    Guitreau, M.; Blichert-Toft, J.; Mojzsis, S. J.; Roth, A. S.; Bourdon, B.

    2012-12-01

    The Nuvvuagittuq supracrustal belt (NSB) in northern Québec (Canada) is a mafic terrane enclosed in the westernmost part of the Minto Block of the Superior Province. This locality became famous after the discovery by [1] of 142Nd deficits in the constituent amphibolites. The age of the NSB is a matter of debate because zircon U-Pb and whole-rock 147Sm-143Nd isotope systematics give Eoarchean ages of ~3.8 Ga, while the short-lived 146Sm-142Nd chronometer indicates a Hadean age of ~4.3 Ga. We present new Lu-Hf isotope data for mafic and felsic rocks from the NSB in an attempt to resolve this age issue and, hence, understand the origin of the negative 142Nd anomalies. The Lu-Hf data define a "scatterchron" yielding an Eoarchean age of 3864±70 Ma, which is consistent with 147Sm-143Nd and U-Pb zircon ages but in disagreement with the Hadean age inferred from 146Sm-142Nd systematics. We interpret the Lu-Hf age as the mean emplacement age of the different autochthonous units of the NSB. The observed alignment of the data along a Lu-Hf "scatterchron" precludes a Hadean age for the NSB because their isotopic characteristics appear to be controlled by long-term radiogenic ingrowth. A Hadean derivation should have caused age differences of hundreds of millions of years to manifest as strong deviations from the observed scatterchron. Furthermore, combined Lu-Hf and Sm-Nd data on the same NSB (Ca-poor cummingtonite- and hornblende-bearing) amphibolite samples define a mixing hyperbola at ca. 3800 Ma with end-member compositions representative of compositional groupings identified for these lithologies [2]. Low 142Nd/144Nd values relative to Bulk Silicate Earth are endemic to the "low-TiO2" amphibolite population, and can be attributed to a Hadean multi-stage history of its mantle source as indicated by rare-earth element patterns. The 142Nd deficits could have developed in response to a later re-fertilization episode within a mantle source depleted by primordial crust

  19. Core-shell-shell heterostructures of α-NaLuF4:Yb/Er@NaLuF4:Yb@MF2 (M = Ca, Sr, Ba) with remarkably enhanced upconversion luminescence.

    PubMed

    Su, Yue; Liu, Xiuling; Lei, Pengpeng; Xu, Xia; Dong, Lile; Guo, Xianmin; Yan, Xingxu; Wang, Peng; Song, Shuyan; Feng, Jing; Zhang, Hongjie

    2016-07-01

    Core-shell-shell heterostructures of α-NaLuF4:Yb/Er@NaLuF4:Yb@MF2 (M = Ca, Sr, Ba) have been successfully fabricated via the thermal decomposition method. Upconversion nanoparticles (UCNPs) were characterized by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), upconversion luminescence (UCL) spectroscopy, etc. Under 980 nm excitation, the emission intensities of the UCNPs are remarkably enhanced after coating the MF2 (M = Ca, Sr, and Ba) shell. Among these samples, CaF2 coated UCNPs show the strongest overall emission, while BaF2 coated UCNPs exhibit the longest lifetime. These results demonstrate that alkaline earth metal fluorides are ideal materials to improve the UCL properties. Meanwhile, although the lattice mismatch between the ternary NaREF4 core and the binary MF2 (M = Sr and Ba) shell is relatively large, the successfully synthesized NaLuF4:Yb/Er@NaLuF4:Yb@MF2 indicates a new outlook on the fabrication of heterostructural core-shell UCNPs. PMID:27327414

  20. Radiation Nanomedicine for EGFR-Positive Breast Cancer: Panitumumab-Modified Gold Nanoparticles Complexed to the β-Particle-Emitter, (177)Lu.

    PubMed

    Yook, Simmyung; Cai, Zhongli; Lu, Yijie; Winnik, Mitchell A; Pignol, Jean-Philippe; Reilly, Raymond M

    2015-11-01

    Our objective was to construct a novel radiation nanomedicine for treatment of breast cancer (BC) expressing epidermal growth factor receptors (EGFR), particularly triple-negative tumors (TNBC). Gold nanoparticles (AuNP; 30 nm) were modified with polyethylene glycol (PEG) chains (4 kDa) derivatized with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelators for complexing the β-emitter, (177)Lu and with PEG chains (5 kDa) linked to panitumumab for targeting BC cells expressing EGFR. The AuNP were further coated with PEG chains (2 kDa) to stabilize the particles to aggregation. The binding and internalization of EGFR-targeted AuNP ((177)Lu-T-AuNP) into BC cells was studied and compared to nontargeted (177)Lu-NT-AuNP. The cytotoxicity of (177)Lu-T-AuNP and (177)Lu-NT-AuNP was measured in clonogenic assays using BC cells with widely different EGFR densities: MDA-MB-468 (10(6) receptors/cell), MDA-MB-231 (10(5) receptors/cell), and MCF-7 cells (10(4) receptors/cell). Radiation absorbed doses to the cell nucleus of MDA-MB-468 cells were estimated based on subcellular distribution. Darkfield and fluorescence microscopy as well as radioligand binding assays revealed that (177)Lu-T-AuNP were specifically bound by BC cells dependent on their EGFR density whereas the binding and internalization of (177)Lu-NT-AuNP was significantly lower. The affinity of binding of (177)Lu-T-AuNP to MDA-MB-468 cells was reduced by 2-fold compared to (123)I-labeled panitumumab (KD = 1.3 ± 0.2 nM vs 0.7 ± 0.4 nM, respectively). The cytotoxicity of (177)Lu-T-AuNP was dependent on the amount of radioactivity incubated with BC cells, their EGFR density and the radiosensitivity of the cells. The clonogenic survival (CS) of MDA-MB-468 cells overexpressing EGFR was reduced to <0.001% at the highest amount of (177)Lu-T-AuNP tested (4.5 MBq; 6 × 10(11) AuNP per 2.5 × 10(4)-1.2 × 10(5) cells). (177)Lu-T-AuNP were less effective for killing MDA-MB-231 cells or MCF-7 cells with

  1. Radiation Nanomedicine for EGFR-Positive Breast Cancer: Panitumumab-Modified Gold Nanoparticles Complexed to the β-Particle-Emitter, (177)Lu.

    PubMed

    Yook, Simmyung; Cai, Zhongli; Lu, Yijie; Winnik, Mitchell A; Pignol, Jean-Philippe; Reilly, Raymond M

    2015-11-01

    Our objective was to construct a novel radiation nanomedicine for treatment of breast cancer (BC) expressing epidermal growth factor receptors (EGFR), particularly triple-negative tumors (TNBC). Gold nanoparticles (AuNP; 30 nm) were modified with polyethylene glycol (PEG) chains (4 kDa) derivatized with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelators for complexing the β-emitter, (177)Lu and with PEG chains (5 kDa) linked to panitumumab for targeting BC cells expressing EGFR. The AuNP were further coated with PEG chains (2 kDa) to stabilize the particles to aggregation. The binding and internalization of EGFR-targeted AuNP ((177)Lu-T-AuNP) into BC cells was studied and compared to nontargeted (177)Lu-NT-AuNP. The cytotoxicity of (177)Lu-T-AuNP and (177)Lu-NT-AuNP was measured in clonogenic assays using BC cells with widely different EGFR densities: MDA-MB-468 (10(6) receptors/cell), MDA-MB-231 (10(5) receptors/cell), and MCF-7 cells (10(4) receptors/cell). Radiation absorbed doses to the cell nucleus of MDA-MB-468 cells were estimated based on subcellular distribution. Darkfield and fluorescence microscopy as well as radioligand binding assays revealed that (177)Lu-T-AuNP were specifically bound by BC cells dependent on their EGFR density whereas the binding and internalization of (177)Lu-NT-AuNP was significantly lower. The affinity of binding of (177)Lu-T-AuNP to MDA-MB-468 cells was reduced by 2-fold compared to (123)I-labeled panitumumab (KD = 1.3 ± 0.2 nM vs 0.7 ± 0.4 nM, respectively). The cytotoxicity of (177)Lu-T-AuNP was dependent on the amount of radioactivity incubated with BC cells, their EGFR density and the radiosensitivity of the cells. The clonogenic survival (CS) of MDA-MB-468 cells overexpressing EGFR was reduced to <0.001% at the highest amount of (177)Lu-T-AuNP tested (4.5 MBq; 6 × 10(11) AuNP per 2.5 × 10(4)-1.2 × 10(5) cells). (177)Lu-T-AuNP were less effective for killing MDA-MB-231 cells or MCF-7 cells with

  2. Tumour control probability derived from dose distribution in homogeneous and heterogeneous models: assuming similar pharmacokinetics, 125Sn-177Lu is superior to 90Y-177Lu in peptide receptor radiotherapy

    NASA Astrophysics Data System (ADS)

    Walrand, Stephan; Hanin, François-Xavier; Pauwels, Stanislas; Jamar, François

    2012-07-01

    Clinical trials on 177Lu-90Y therapy used empirical activity ratios. Radionuclides (RN) with larger beta maximal range could favourably replace 90Y. Our aim is to provide RN dose-deposition kernels and to compare the tumour control probability (TCP) of RN combinations. Dose kernels were derived by integration of the mono-energetic beta-ray dose distributions (computed using Monte Carlo) weighted by their respective beta spectrum. Nine homogeneous spherical tumours (1-25 mm in diameter) and four spherical tumours including a lattice of cold, but alive, spheres (1, 3, 5, 7 mm in diameter) were modelled. The TCP for 93Y, 90Y and 125Sn in combination with 177Lu in variable proportions (that kept constant the renal cortex biological effective dose) were derived by 3D dose kernel convolution. For a mean tumour-absorbed dose of 180 Gy, 2 mm homogeneous tumours and tumours including 3 mm diameter cold alive spheres were both well controlled (TCP > 0.9) using a 75-25% combination of 177Lu and 90Y activity. However, 125Sn-177Lu achieved a significantly better result by controlling 1 mm-homogeneous tumour simultaneously with tumours including 5 mm diameter cold alive spheres. Clinical trials using RN combinations should use RN proportions tuned to the patient dosimetry. 125Sn production and its coupling to somatostatin analogue appear feasible. Assuming similar pharmacokinetics 125Sn is the best RN for combination with 177Lu in peptide receptor radiotherapy justifying pharmacokinetics studies in rodent of 125Sn-labelled somatostatin analogues.

  3. Comparison of ⁹⁰Y and ¹⁷⁷Lu measurement capability in UK and European hospitals.

    PubMed

    Fenwick, Andrew; Baker, Michaela; Ferreira, Kelley; Keightley, John

    2014-05-01

    Comparison exercises involving (90)Y and (177)Lu were performed during 2009 and 2012, respectively, to assess the measurement capability of hospitals in the UK and Europe. The results from the measurement of a typical liquid solution of (90)Y show that only 40% of participants could measure the solution to within 5% of the certificated value and that a significant -6% bias was present due to the use of non-standard geometries for the calibration of equipment. The results from the measurement of a standard liquid solution of (177)Lu show that 81% of participants could measure to within 5% of the certificated value and in fact 65% of these results were within 2% of the certificated value, showing administered activities can be far more accurately measured for (177)Lu than for (90)Y and that (177)Lu has a far smaller geometry dependence. These studies were performed to identify specific measurement issues in the user community and to identify areas where future research should be focused. In addition to this the work allows the participants to adjust measurement practice and identify key measurement issues.

  4. Features of the band structure and conduction mechanisms of n-HfNiSn semiconductor heavily Lu-doped

    SciTech Connect

    Romaka, V. A.; Rogl, P.; Romaka, V. V.; Kaczorowski, D.; Stadnyk, Yu. V.; Korzh, R. O.; Krayovskyy, V. Ya.; Kovbasyuk, T. M.

    2015-03-15

    The crystal and electronic structures, energy, kinetic, and magnetic characteristics of n-HfNiSn semiconductor heavily doped with a Lu acceptor impurity in the ranges T = 80–400 K and N{sub A}{sup Lu} ≈ 1.9 × 10{sup 20}−1.9 × 10{sup 21} cm{sup −3} (x = 0.01–0.10) at H ≤ 10 kG is studied. The nature of the structural-defect generation mechanism leading to changes in the band gap and the degree of semiconductor compensation is determined. Its essence is the simultaneous reduction and elimination of donor-type structural defects due to the displacement of ∼1% of Ni atoms from the Hf (4a) site, the generation of acceptor-type structural defects by substituting Ni atoms with Lu atoms at the 4c site, and the generation of donor-type defects such as vacancies at the Sn (4b) site. The results of calculations of the electronic structure of Hf{sub 1−x}Lu{sub x}NiSn are in agreement with experimental data. The results are discussed within the model of a heavily doped and compensated Shklovskii-Efros semiconductor.

  5. White light emission from Dy3+-doped LiLuF4 single crystal grown by Bridgman method

    NASA Astrophysics Data System (ADS)

    Dong, Yan-ming; Xia, Hai-ping; Fu, Li; Li, Shan-shan; Gu, Xue-mei; Zhang, Jian-li; Wang, Dong-jie; Zhang, Yue-pin; Jiang, Hao-chuan; Chen, Bao-jiu

    2014-07-01

    Lithium lutetium fluoride (LiLuF4) single crystals doped with different Dy3+ ion concentrations were grown by Bridgman method. The Judd-Ofelt (J-O) strength parameters ( Ω 2, Ω 4, Ω 6) of Dy3+ in LiLuF4 crystal are calculated according to the measured absorption spectra and the J-O theory, by which the asymmetry of the Dy3+:LiLuF4 single crystal and the possibility of attaining stimulated emission from 4F9/2 level are analyzed. The capability of the Dy3+:LiLuF4 crystal in generating white light by simultaneous blue and yellow emissions under excitation with ultraviolet light is produced. The effects of excitation wavelength and doping concentration on chromaticity coordinates and photoluminescence intensity are also investigated. Favorable CIE coordinates, x=0.319 3 and y=0.349 3, can be obtained for Dy3+ ion in 2.701% molar doping concentration under excitation of 350 nm.

  6. IMPROVED PLANAR KIDNEY ACTIVITY CONCENTRATION ESTIMATE BY THE POSTERIOR VIEW METHOD IN 177LU-DOTATATE TREATMENTS

    PubMed Central

    Magnander, Tobias; Svensson, Johanna; Båth, Magnus; Gjertsson, Peter; Bernhardt, Peter

    2016-01-01

    The aims of this study were to determine how different background regions of interest (ROIs) around the kidney represent true background activity in over- and underlying tissues in 177Lu-DOTA-octreatate (177Lu-DOTATATE) treatments and to determine the influence of the background positions on the kidney activity concentration estimates by the conjugate view (ConjV) and posterior view (PostV) methods. The analysis was performed in single-photon emission computed tomography (SPECT) images of 20 patients, acquired 24 h post injection of a 177Lu-DOTATATE treatment, by a computer algorithm that created planar images from the SPECT data. The ratio between the activity concentration in the background and the true background varied from 0.36 to 2.08 [coefficient of variation (CV) = 25–181 %] and from 0.44 to 1.52 (CV = 16–70 %) for the right and left kidneys, respectively. The activity concentration estimate in the kidneys was most accurate with the PostV method using a background ROI surrounding the whole kidney, and this combination might be an alternative planar method for improved kidney dosimetry in the 177Lu-DOTATATE treatments. PMID:27012883

  7. Correlation between structure and optical properties in (Y,Lu)3Al5O12:Ce3+ solid solutions

    NASA Astrophysics Data System (ADS)

    Zhang, Mei; Li, Bowen; Yang, Yingshu; Chen, Shuijin; He, Xin; Zhao, Fenghua; Zeng, Qingguang

    2016-10-01

    A series of (Y,Lu)3Al5O12:Ce3+ (YLuAG:Ce) solid solutions were synthesized via the solid-state reaction route. The phosphors are all of the cubic garnet crystal structures confirmed by x-ray diffraction (XRD). The internal quantum efficiency and emission intensity of the phosphors can be enhanced by increasing the Lu3+ content in the host lattice, along with a blue shift of the emission peak. In addition, the blue shift of the emission peak correlates very well with the lattice contraction. Intense light-emitting diodes (LEDs) are successfully fabricated based on the YLuAG:Ce phosphors and 450 nm blue Ga(In)N chips. The luminous efficiency of YLuAG:Ce phosphors converted LEDs increases with elevating Lu3+ concentration. The results indicate that Ce3+ doped YLuAG solid solutions, especially LuAG:Ce phosphor is a promising green phosphor for solid-state lighting.

  8. Ecological studies of the bio-inoculant Trichoderma hamatum LU592 in the root system of Pinus radiata.

    PubMed

    Hohmann, Pierre; Jones, Elisabeth Eirian; Hill, Robert A; Stewart, Alison

    2012-06-01

    The plant health- and growth-promoting biological inoculant (bio-inoculant) Trichoderma hamatum LU592 was transformed with the constitutively expressed green fluorescent protein (gfp) and hygromycin B resistance (hph) genes to specifically monitor the isolate in the root system of Pinus radiata within a strong indigenous Trichoderma population. A modified dilution plating technique was developed to allow the determination of the mycelia proportion of total propagule levels. LU592 was shown to colonize the rhizosphere most effectively when 10(5)  spores per pot were applied compared with inoculum concentrations of 10(3) and 10(7)  spores per pot. LU592 extended its zone of activity beyond the rhizosphere to at least 1 cm away from the root surface. A positive relationship was shown between P. radiata root maturation and the spatial and temporal proliferation of LU592 in the root system. A steep increase in mycelia levels and proportion of penetrated root segments was observed after 12 weeks. This study reinforces the value of genetic markers for use in ecological studies of filamentous fungi. However, despite isolate-specific recovery of the introduced isolate, it was shown that total propagule counts do not always correlate with the amount of viable mycelium present in the root system. Therefore, it is proposed that the differentiation of mycelia from spores and root penetration is used as more accurate measures of fungal activity.

  9. Observation of direct magneto-dielectric behaviour in Lu3Fe5O12-δ above room-temperature.

    PubMed

    Manimuthu, P; Vidya, R; Ravindran, P; Fjellvåg, H; Venkateswaran, C

    2015-07-21

    The coupling of dielectric and magnetic order is highly nontrivial and seldom observed in rare-earth iron garnets. Careful investigations on polycrystalline Lu3Fe5O12-δ, prepared by the solid state route, establish a direct correlation between the magnetic and dielectric order parameters. A dielectric anomaly at the magnetic ordering temperature supports this correlation. The dielectric permittivity at various magnetic fields is measured using an indigenously developed connector setup. Lu3Fe5O12-δ exhibits a magneto-dielectric coupling of ∼6% at room temperature, which is significant in the case of a single-phase magneto-dielectric material at low fields. Rietveld refinement of the X-ray diffraction pattern, bond valence sum method, Mössbauer spectroscopy, and X-ray photoelectron spectroscopy indicate two different oxidation states of Fe. Complete structural optimizations performed using the density functional theory establish a ferrimagnetic ground state and provide structural parameters in agreement with experimental values. Electronic structure analysis shows that Lu3Fe5O12 exhibits insulating behavior both in ferromagnetic and ferrimagnetic configurations. The capability of Lu3Fe5O12-δ to exhibit room temperature magneto-dielectric response is a key factor in designing and fabricating various electronic devices and sensors.

  10. Acupuncture points in the book of Şerefeddin Sabuncuoğlu, a 15th century Turkish physician.

    PubMed

    Acar, H Volkan

    2015-02-01

    Şerefeddin Sabuncuoğlu (1385-1468?), the author of Cerrahiyetü'l-Haniyye (Imperial Surgery), was a distinguished Ottoman Turkish surgeon. The first illustrated Turkish surgical textbook, Cerrahiyetü'l-Haniyye consisted of three chapters (ie, cauterisation treatments, surgical procedures and fractures and dislocations). Although the main source of the book was Al-Tasrif (Textbook of Surgery) by Albucasis (Abu al-Qasim al-Zahrawi; 936-1013 AD), Sabuncuoğlu added much new information, his clinical experiences and suggestions. The original illustrations and human figures made Cerrahiyetü'l-Haniyye the first illustrated medical textbook in Turkish and Islamic medicine literature. Cerrahiyetü'l-Haniyye was also a valuable source for acupuncturists. Some new sections and additions revealed that Sabuncuoğlu had knowledge of Chinese medicine. In four sections of Cerrahiyetü'l-Haniyye (ie, toothache, haemorrhoids, eczema and dermatophytosis) Sabuncuoğlu described acupuncture techniques and point locations. It is likely that the Chinese medicine content of Cerrahiyetü'l-Haniyye was derived from Central Asian roots of Anatolian Turkish people.

  11. Relativistic many-body calculation of energies, lifetimes, polarizabilities, blackbody radiative shift, and hyperfine constants in Lu2 +

    NASA Astrophysics Data System (ADS)

    Safronova, U. I.; Safronova, M. S.; Johnson, W. R.

    2016-09-01

    Energy levels of 30 low-lying states of Lu2 + and allowed electric-dipole matrix elements between these states are evaluated using a relativistic all-order method in which all single, double, and partial triple excitations of Dirac-Fock wave functions are included to all orders of perturbation theory. Matrix elements are critically evaluated for their accuracy and recommended values of the matrix elements are given together with uncertainty estimates. Line strengths, transition rates, and lifetimes of the metastable 5 d3 /2 and 5 d5 /2 states are calculated. Recommended values are given for static polarizabilities of the 6 s , 5 d , and 6 p states and tensor polarizabilities of the 5 d and 6 p3 /2 states. Uncertainties of the polarizability values are estimated in all cases. The blackbody radiation shift of the 6 s1 /2-5 d5 /2 transition frequency of the Lu2 + ion is calculated with the aid of the recommended scalar polarizabilities of the 6 s1 /2 and 5 d5 /2 states. Finally, A and B hyperfine constants are determined for states of 2+175Lu with n ≤9 . This work provides recommended values of transition matrix elements, polarizabilities, and hyperfine constants of Lu2 +, critically evaluated for accuracy, for benchmark tests of high-precision theoretical methodology and planning of future experiments.

  12. [Control effect and bacteriostasis of mulberry endophytic bacterium Burkholderia cepacia Lu10-1 on silkworm septicemia].

    PubMed

    Dong, Fa-Bao; Mu, Zhi-Mei; Yu, Qi; Zhao, Kai; Liu, Zhao-Yang; Wang, Yan-Wen; Gao, Hui-Ju

    2012-11-01

    A laboratory test was conducted to study the control effect and bacteriostasis of antagonistic bacterium Burkholderia cepacia Lu10-1 isolated from mulberry on silkworm septicemia, aimed to develop a new microbial pesticide to control silkworm diseases. The supernatant of Lu10-1 zymotic fluid achieved 41.2% control efficiency and 24.0% prophylactic effect on silkworm septicemia. The antibacterial crude extract of Lu10-1 had stronger antagonistic activity against Bacillus bombyseptieus. The diameter of inhibition zone reached 18.20 mm, and the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of the antibacterial crude extract were 1.56 and 3.13 mg x mL(-1), respectively. After treated with the antibacterial crude extract, B. bombyseptieus never appeared logarithmic growth phase, its cell membrane permeability changed, intracellular protein leaked out, intracellular macromolecular protein degraded, and at last, the thalli cracked, inner substances out-flowed, cavity formed, and cell ablated. It was considered that the antagonistic substances of Lu10-1 strain could be used for controlling silkworm septicemia, with preferable development foreground. PMID:23431798

  13. Synthesis of NaYF4 and NaLuF4 Based Upconversion Nanocrystals and Comparison of Their Properties.

    PubMed

    Ouyang, Juan; Yin, Dongguang; Song, Kailin; Wang, Chengcheng; Liu, Bing; Wu, Minghong

    2015-04-01

    In this study, four kinds of upconversion nanocrystals (UCNs) have been successfully synthesized by a facile solvothermal method. The morphology, crystalline phase, composition, grain size, upconversion luminescence and cell image of the UCNs were investigated. The properties of the NaLuF4-based UCNs were compared with the counterparts of NaYF4-based UCNs. It is found that the NaLuF4-based UCNs are apt to form hexagonal phase structures, while NaYF4-based UCNs of NaYF4:Yb, Er and NaYF4:Gd, Yb, Er are cubic and hexagonal phases respectively. The upconversion emission intensities of the NaLuF4-based UCNs are higher than that of NaYF4-based UCNs, and Gd3+ presented UCNs are higher than that of Gd3+ absented UCNs. The bioimaging application of NaLuF4:Gd, Yb, Er shows that bright upconversion luminescence can be observed when UCNs-labeled HeLa cells are excited with 980 nm light. PMID:26353495

  14. Effects of disorder and isotopic substitution in the specific heat and Raman scattering in LuB{sub 12}

    SciTech Connect

    Sluchanko, N. E. Azarevich, A. N.; Bogach, A. V.; Vlasov, I. I.; Glushkov, V. V.; Demishev, S. V.; Maksimov, A. A.; Tartakovskii, I. I.; Filatov, E. V.; Flachbart, K.; Gabani, S.; Filippov, V. B.; Shitsevalova, N. Yu.; Moshchalkov, V. V.

    2011-09-15

    Precision measurements of the specific heat and spectral intensity I({omega}) of Raman scattering for Lu{sup N}B{sub 12} single crystal samples with various boron isotopes (N = 10, 11, nat) have been performed at low and intermediate temperatures. A boson peak in the low-frequency part of the I({omega}) spectrum has been observed for the first time for lutetium dodecaboride at liquid nitrogen temperatures. It has been shown that low-temperature anomalies in the specific heat, along with the features of Raman spectra, can be interpreted in terms of the transition to a cageglass state at T* = 50-70 K, which appears when Lu{sup 3+} ions are displaced from the centrosymmetric position in cavities of a rigid covalent boron sublattice towards the randomly located boron vacancies. The concentrations of various two-level systems that correspond to two types of vibrational clusters with correlation lengths of 12-15 and 18-22 A, respectively, have been estimated. The vibrational density of states of LuB{sub 12} has been calculated from Raman spectra in the model of soft atomic potentials. An approach has been proposed to explain the dielectrization of the properties of the YbB{sub 12} compound at T < T*, as well as the features of the formation of magnetic structures in RB{sub 12} antiferromagnets (R = Tb, Dy, Ho, Er, Tm) and the suppression of superconductivity in LuB{sub 12}.

  15. Synthesis of NaYF4 and NaLuF4 Based Upconversion Nanocrystals and Comparison of Their Properties.

    PubMed

    Ouyang, Juan; Yin, Dongguang; Song, Kailin; Wang, Chengcheng; Liu, Bing; Wu, Minghong

    2015-04-01

    In this study, four kinds of upconversion nanocrystals (UCNs) have been successfully synthesized by a facile solvothermal method. The morphology, crystalline phase, composition, grain size, upconversion luminescence and cell image of the UCNs were investigated. The properties of the NaLuF4-based UCNs were compared with the counterparts of NaYF4-based UCNs. It is found that the NaLuF4-based UCNs are apt to form hexagonal phase structures, while NaYF4-based UCNs of NaYF4:Yb, Er and NaYF4:Gd, Yb, Er are cubic and hexagonal phases respectively. The upconversion emission intensities of the NaLuF4-based UCNs are higher than that of NaYF4-based UCNs, and Gd3+ presented UCNs are higher than that of Gd3+ absented UCNs. The bioimaging application of NaLuF4:Gd, Yb, Er shows that bright upconversion luminescence can be observed when UCNs-labeled HeLa cells are excited with 980 nm light.

  16. IMPROVED PLANAR KIDNEY ACTIVITY CONCENTRATION ESTIMATE BY THE POSTERIOR VIEW METHOD IN 177LU-DOTATATE TREATMENTS.

    PubMed

    Magnander, Tobias; Svensson, Johanna; Båth, Magnus; Gjertsson, Peter; Bernhardt, Peter

    2016-06-01

    The aims of this study were to determine how different background regions of interest (ROIs) around the kidney represent true background activity in over- and underlying tissues in (177)Lu-DOTA-octreatate ((177)Lu-DOTATATE) treatments and to determine the influence of the background positions on the kidney activity concentration estimates by the conjugate view (ConjV) and posterior view (PostV) methods. The analysis was performed in single-photon emission computed tomography (SPECT) images of 20 patients, acquired 24 h post injection of a (177)Lu-DOTATATE treatment, by a computer algorithm that created planar images from the SPECT data. The ratio between the activity concentration in the background and the true background varied from 0.36 to 2.08 [coefficient of variation (CV) = 25-181 %] and from 0.44 to 1.52 (CV = 16-70 %) for the right and left kidneys, respectively. The activity concentration estimate in the kidneys was most accurate with the PostV method using a background ROI surrounding the whole kidney, and this combination might be an alternative planar method for improved kidney dosimetry in the (177)Lu-DOTATATE treatments. PMID:27012883

  17. IMPROVED PLANAR KIDNEY ACTIVITY CONCENTRATION ESTIMATE BY THE POSTERIOR VIEW METHOD IN 177LU-DOTATATE TREATMENTS.

    PubMed

    Magnander, Tobias; Svensson, Johanna; Båth, Magnus; Gjertsson, Peter; Bernhardt, Peter

    2016-06-01

    The aims of this study were to determine how different background regions of interest (ROIs) around the kidney represent true background activity in over- and underlying tissues in (177)Lu-DOTA-octreatate ((177)Lu-DOTATATE) treatments and to determine the influence of the background positions on the kidney activity concentration estimates by the conjugate view (ConjV) and posterior view (PostV) methods. The analysis was performed in single-photon emission computed tomography (SPECT) images of 20 patients, acquired 24 h post injection of a (177)Lu-DOTATATE treatment, by a computer algorithm that created planar images from the SPECT data. The ratio between the activity concentration in the background and the true background varied from 0.36 to 2.08 [coefficient of variation (CV) = 25-181 %] and from 0.44 to 1.52 (CV = 16-70 %) for the right and left kidneys, respectively. The activity concentration estimate in the kidneys was most accurate with the PostV method using a background ROI surrounding the whole kidney, and this combination might be an alternative planar method for improved kidney dosimetry in the (177)Lu-DOTATATE treatments.

  18. Hémorragie méningée et hématome parenchymateux révélant une thrombose veineuse cérébrale

    PubMed Central

    Joulali, Toufik; Derkaoui, Ali; Besri, Sophia; Malki, Mohammed; Shimi, Abdelkarim; Khatouf, Mohammed

    2015-01-01

    La thrombophlébite cérébrale (TVC) est une cause non négligeable des accidents vasculaires cérébraux avec une grande diversité de leur présentation Clinique source d'errance et de retard thérapeutique. Nous rapportons l'observation d'une patiente présentant une TVC révélée par une hémorragie méningée. Le diagnostic a été suspecté à l'artériographie réalisée dans le cadre du bilan étiologique et thérapeutique de l'hémorragie méningée et confirmé par la suite sur l'angio-scanner. La particularité de cette observation est la difficulté aussi bien diagnostique de la TVC et sa révélation par une hémorragie méningée, que thérapeutique concernant l'utilisation des anticoagulants. PMID:26161216

  19. Lu-Hf dating, petrography, and tectonic implications of the youngest Alpine eclogites (Tauern Window, Austria)

    NASA Astrophysics Data System (ADS)

    Nagel, T. J.; Herwartz, D.; Rexroth, S.; Münker, C.; Froitzheim, N.; Kurz, W.

    2013-06-01

    Isotopic dating of metamorphic minerals places fundamental constraints on the rates and mechanisms of burial and exhumation in collisional orogens. The Eclogite Zone in the Tauern Window has been the focus of many studies on subduction-related high-pressure metamorphism. However, the age and duration of the high-pressure stage remains the subject of ongoing debate. 32 Ma Sr-Rb ages interpreted to date eclogite-facies metamorphism (Glodny et al., 2005) appear too young in traditional tectonic reconstructions of plate collision in the Alps. These ages have either been interpreted to indicate extremely rapid exhumation from more than 60 kilometre depth to mid-crustal levels within 1 Ma years or to date retrogression subsequent to high-pressure metamorphism. We present element distribution maps and lutetium-hafnium (Lu-Hf) garnet ages of three samples from the Eclogite Zone. All samples display almost unaltered eclogite-facies assemblages and garnets preserve growth zoning. Lu-Hf ages are thus considered as formation ages recording metamorphism towards peak-pressure conditions. In the sample with the smallest grain size, garnet shows regular bell-shaped element distributions with respect to manganese and the iron-magnesium ratio. A six-point isochron of this sample yields 32.8 ± 0.5 Ma (MSWD = 1.06), interpreted as the age of Alpine eclogite-facies metamorphism. In one of the other two, coarser-grained samples' garnet chemistry is identical. The third sample, however, shows complex zoning in large garnet crystals. Cores with a very low iron-magnesium ratio are surrounded by a second garnet generation which is very similar to the Alpine generation in the other two samples. The two coarser-grained samples yield scattered ages between 26.9 ± 9.8 Ma and 62.7 ± 1.8 Ma for individual garnet-whole-rock pairs as the analysed garnet fractions display very different 176Hf/177Hf vs. 176Lu/177Hf ratios. This scatter reflects varying degrees of mixing between Alpine and pre

  20. Evaluation of radiation safety in (177)Lu-PSMA therapy and development of outpatient treatment protocol.

    PubMed

    Demir, Mustafa; Abuqbeitah, Mohammad; Uslu-Beşli, Lebriz; Yıldırım, Özlem; Yeyin, Nami; Çavdar, İffet; Vatankulu, Betül; Gündüz, Hüseyin; Kabasakal, Levent

    2016-06-01

    The aim of this study is to investigate the outpatient treatment protocol and radiation safety of a new-emerging lutetium-177 ((177)Lu) prostate specific membrane antigen (PSMA) therapy. This work analyzed the dose rate of 23 patients treated with 7400 MBq (177)Lu-PSMA at different distances (0, 0.25, 0.50, 1.0 and 2.0 m) and variable time marks (0, 1, 2, 4, 18, 24, 48 and 120 h) after the termination of infusion. Blood samples were withdrawn from 17 patients within the same group at 3, 10, 20, 40, 60 and 90 min and 2, 3, 24 h after termination of infusion. Seven different patients were asked to collect urine for 24 h and a gamma well counter was used for counting samples. Family members were invited to wear an optically stimulated luminescence dosimeter whenever they were in the proximity of the patients up to 4-5 d. The total dose of the medical team including the radiopharmacist, physicist, physician, nurse, and nuclear medicine technologist was estimated by an electronic personnel dosimeter. The finger dose was determined using a ring thermoluminescent dosimeter for the radiopharmacist and nurse. The mean dose rate at 1 m after 4 h and 6 h was 23  ±  6 μSv h(-1) and 15  ±  4 μSv h(-1) respectively. The mean total dose to 23 caregivers was 202.3  ±  42.7 μSv (range: 120-265 μSv). The radiation dose of the nurse and radiopharmacist was 6 and 4 μSv per patient, respectively, whereas the dose of the physicist and physician was 2 μSv. The effective half life of blood distribution and early elimination was 0.4  ±  0.1 h and 5  ±  1 h, respectively. Seven patients excreted a mean of 45% (range: 32%-65%) from the initial activity in 6 h. Our findings demonstrate that (177)Lu-PSMA is a safe treatment modality to be applied as an outpatient protocol, since the dose rate decreases below the determined threshold of  <30 μSv h(-1) after approximately 5 h and degrades to 20 μSv h(-1) after 6

  1. Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice

    PubMed Central

    Schüler, Emil; Larsson, Maria; Parris, Toshima Z.; Johansson, Martin E.; Helou, Khalil; Forssell-Aronsson, Eva

    2015-01-01

    The kidneys are one of the main dose-limiting organs in peptide receptor radionuclide therapy and due to large inter-individual variations in renal toxicity, biomarkers are urgently needed in order to optimize therapy and reduce renal tissue damage. The aim of this study was to investigate the transcriptional, functional, and morphological effects on renal tissue after 177Lu-octreotate administration in normal mice, and to identify biomarkers for radiation induced renal toxicity. Methods C57BL/6N mice were i.v. injected with 0, 30, 60, 90, 120, or 150 MBq 177Lu-octreotate (0, 16, 29, 40, 48, and 54 Gy to the kidneys). At 4, 8, and 12 months after administration, radiation-induced effects were evaluated in relation to (a) global transcriptional variations in kidney tissues, (b) morphological changes in the kidneys, (c) changes in white and red blood cell count as well as blood levels of urea, and (d) changes in renal function using 99mTc-DTPA/99mTc-DMSA scintigraphy. Results In general, the highest number of differentially regulated transcripts was observed at 12 months after administration. The Cdkn1a, C3, Dbp, Lcn2, and Per2 genes displayed a distinct dose-dependent regulation, with increased expression level with increasing absorbed dose. Ifng, Tnf, and Il1B were identified as primary up-stream regulators of the recurrently regulated transcripts. Furthermore, previously proposed biomarkers for kidney injury and radiation damage were also observed. The functional investigation revealed reduced excretion of 99mTc-DTPA after 150 MBq, an increased uptake of 99mTc-DMSA at all dose levels compared with the controls, and markedly increased urea level in blood after 150 MBq at 12 months. Conclusion Distinct dose-response relationships were found for several of the regulated transcripts. The Cdkn1a, Dbp, Lcn2, and Per2 genes are proposed as biomarkers for 177Lu-octreotate exposure of kidney. Correlations to functional and morphological effects further confirm

  2. The in vivo disposition and in vitro transmembrane transport of two model radiometabolites of DOTA-conjugated receptor-specific peptides labelled with (177) Lu.

    PubMed

    Volková, Marie; Mandíková, Jana; Bárta, Pavel; Navrátilová, Lucie; Lázníčková, Alice; Trejtnar, František

    2015-01-01

    In vivo metabolism of the radiolabelled receptor-specific peptides has been described; however, information regarding the pharmacokinetic behaviour of the degradation products within the body is very scarce. The present study was designed to obtain new knowledge on the disposition and elimination of low-molecular radiometabolites of receptor-specific peptides in the organism and to reveal the potential involvement of selected membrane transport mechanisms in the cellular uptake of radiometabolites, especially in the kidney. The study compared pharmacokinetics of two radiometabolites: a final metabolite of somatostatin analogues, (177)Lu-DOTA-DPhe, and a tripeptide metabolite of (177)Lu-DOTA-minigastrin 11, (177)Lu-DOTA-DGlu-Ala-Tyr. Their pharmacokinetics was compared with that of respective parent (177)Lu-radiopeptide. Both radiometabolites exhibited relative rapid clearing from most body tissues in rats in vivo along with predominant renal excretion. The long-term renal retention of the smaller radiometabolite (177)Lu-DOTA-DPhe was lower than that of (177)Lu-DOTA-DGlu-Ala-Tyr. An uptake of (177)Lu-DOTA-DPhe by human renal influx transporter organic cation transporter 2 was found in vitro in a cellular model. The study brings the first experimental data on the in vivo pharmacokinetics of radiometabolites of receptor-specific somatostatin and gastrin analogues. The found results may indicate a negative correlation between the degree of decomposition of the parent peptide chain and the renal retention of the metabolite. PMID:26526343

  3. Therapeutic response and side effects of repeated radioligand therapy with 177Lu-PSMA-DKFZ-617 of castrate-resistant metastatic prostate cancer

    PubMed Central

    Ahmadzadehfar, Hojjat; Eppard, Elisabeth; Kürpig, Stefan; Fimmers, Rolf; Yordanova, Anna; Schlenkhoff, Carl Diedrich; Gärtner, Florian; Rogenhofer, Sebastian; Essler, Markus

    2016-01-01

    Prostate-specific membrane antigen (PSMA) is highly expressed on prostate epithelial cells and strongly up-regulated in prostate cancer (PC), making it an optimal target for the treatment of metastasized PC. Radioligand therapy (RLT) with 177Lu-PSMA-DKFZ-617 (Lu-PSMA) is a targeted therapy for metastatic PC. In this study, we retrospectively analyzed the side effects and the response rate of 24 hormone and/or chemorefractory PC patients with a mean age of 75.2 years (range: 64–82) with distant metastases and progressive disease according to the PSA level, who were treated with Lu-PSMA. Median PSA was 522 ng/ml (range: 17–2360). Forty-six cycles of Lu-PSMA were performed. Of the 24 patients, 22 received two cycles. Eight weeks after the first cycle of Lu-PSMA therapy 79.1% experienced a decline in PSA level. Eight weeks after the second cycle of Lu-PSMA therapy 68.2% experienced a decline in PSA relative to the baseline value. Apart from two cases of grade 3 anemia, there was no relevant hemato- or nephrotoxicity (grade 3 or 4). These results confirmed that Lu-PSMA is a safe treatment option for metastatic PC patients and has a low toxicity profile. A positive response to therapy in terms of decline in PSA occurs in about 70% of patients. PMID:26871285

  4. Indirect Production of No Carrier Added (NCA) (177)Lu from Irradiation of Enriched (176)Yb: Options for Ytterbium/Lutetium Separation.

    PubMed

    Dash, Ashutosh; Chakravarty, Rubel; Knapp, Furn F Russ; Pillai, Ambikalmajan M R

    2015-01-01

    This article presents a concise review of the production of no-carrier-added (NCA) (177)Lu by the 'indirect' route by irradiating ytterbium-176 ((176)Yb)-enriched targets. The success of this production method depends on the ability to separate the microscopic amounts of NCA (177)Lu from bulk irradiated ytterbium targets. The presence of Yb(+3) from the target in the final processed (177)Lu will adversely affect the quality of (177)Lu by decreasing the specific activity and competing with Lu(+3) complexation since ytterbium will follow the same coordination chemistry. Ytterbium and lutetium are adjacent members of the lanthanide family with very similar chemical properties which makes the separation of one from the other a challenging task. This review provides a summary of the methods developed for the separation and purification of NCA (177)Lu from neutron irradiated (176)Yb-enriched targets, a critical assessment of recent developments and a discussion of the current status of this (177)Lu production method.

  5. An assessment tumor targeting ability of (177)Lu labeled cyclic CCK analogue peptide by binding with cholecystokinin receptor.

    PubMed

    Cho, Eun-Ha; Lim, Jae Cheong; Lee, So-Young; Jung, Sung-Hee

    2016-07-01

    The cholecystokinin (CCK) receptor is known as a receptor that is overexpressed in many human tumors. The present study was designed to investigate the targeting ability of cyclic CCK analogue in AR42J pancreatic cells. The CCK analogues, DOTA-K(glucose)-Gly-Trp-Nle-Asp-Phe (DOTA-glucose-CCK) and DOTA-Nle-cyclo(Glu-Trp-Nle-Asp-Phe-Lys-NH2) (DOTA-[Nle]-cCCK), were synthesized and radiolabeled with (177)Lu, and competitive binding was evaluated. The binding appearance of synthesized peptide with AR42J cells was evaluated by confocal microscopy. And bio-distribution was performed in AR42J xenografted mice. Synthesized peptides were prepared by a solid phase synthesis method, and their purity was over 98%. DOTA is the chelating agent for (177)Lu-labeling, in which the peptides were radiolabeled with (177)Lu by a high radiolabeling yield. A competitive displacement of (125)I-CCK8 on the AR42J cells revealed that the 50% inhibitory concentration value (IC50) was 12.3 nM of DOTA-glucose-CCK and 1.7 nM of DOTA-[Nle]-cCCK. Radio-labeled peptides were accumulated in AR42J tumor in vivo, and %ID/g of the tumor was 0.4 and 0.9 at 2 h p.i. It was concluded that (177)Lu-DOTA-[Nle]-cCCK has higher binding affinity than (177)Lu-DOTA-glucose-CCK and can be a potential candidate as a targeting modality for a CCK receptor over-expressing tumors. PMID:27430985

  6. Sub-10 nm lanthanide doped BaLuF{sub 5} nanocrystals: Shape controllable synthesis, tunable multicolor emission and enhanced near-infrared upconversion luminescence

    SciTech Connect

    Rao, Ling; Lu, Wei; Wang, Haibo; Yi, Zhigao; Zeng, Songjun; Li, Zheng

    2015-04-15

    Highlights: • Sub-10 nm cubic phase BaLuF{sub 5} nanocrystals were synthesized by a hydrothermal method for the first time. • Tunable multicolor from yellow to yellow-green was achieved by controlling Gd{sup 3+} content in BaLuF{sub 5}:Yb/Er system. • Intense near-infrared upconversion luminescence in BaLuF{sub 5}:Gd/Yb/Tm nanocrystal. • The enhancement near-infrared luminescence can be realized by adjusting the content of Gd{sup 3+} in BaLuF{sub 5}:Gd/Yb/Tm system. - Abstract: In this study, sub-10 nm BaLuF{sub 5} nanocrystals with cubic phase structure were synthesized by a solvothermal method using oleic acid as the stabilizing agent. The as-prepared BaLuF{sub 5} nanocrystals were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), and analyzed by the upconversion (UC) spectra. The TEM results reveal that these samples present high uniformity. Compared with Gd-free samples, the size of BaLuF{sub 5}:Yb/Er doped with 10% Gd{sup 3+} decreased to 5.6 nm. In addition, BaLuF{sub 5}:Yb/Tm/Gd upconversion nanoparticles (UCNPs) presented efficient near-infrared (NIR)-NIR UC luminescence. Therefore, it is expected that these ultra-small BaLuF{sub 5} nanocrystals with well-controlled shape, size, and UC emission have potential applications in biomedical imaging fields.

  7. Constraints on Lu-Hf and Nb-Ta systematics in globally subducted oceanic crust from a survey of orogenic eclogites and amphibolites

    NASA Astrophysics Data System (ADS)

    Zirakparvar, N. Alex

    2016-04-01

    To further understand Lu-Hf and Nb-Ta systematics in globally subducted oceanic crust, this paper evaluates all available Lu-Hf garnet isochron ages and initial ɛHf values in conjunction with present-day bulk-rock Lu-Hf isotope and trace element (K, Nb, Ta, Zr, and Ti in addition to Lu-Hf) data from the world's orogenic eclogites and amphibolites (OEAs). Approximately half of OEAs exhibit Lu-Hf and Nb-Ta systematics mimicking those of unsubducted oceanic crust whereas the rest exhibit variability in one or both systems. For the Lu-Hf system, mixing calculations demonstrate that subduction-related phase transformations, in conjunction with open system behavior, can shift subducted oceanic crust toward higher Lu/Hf, or toward lower Lu/Hf that can also be associated with unradiogenic ɛHf values. However, evaluation of potential mechanisms for fractionating Nb from Ta is more complicated because many of the OEAs have Nb-Ta systematics that are decoupled from Lu-Hf and the behavior of K, Zr, and Ti. Nonetheless, the global data set demonstrates that the association between unradiogenic ɛHf and elevated Nb/Ta observed in some kimberlitic eclogite xenoliths can be inherited from processes that occurred during subduction of their oceanic crustal protoliths. This allows for a geologically based estimate of the Nb concentration in a reservoir composed of deeply subducted oceanic crust. However, mass balance calculations confirm that such a reservoir, when considered as a whole, likely has a Nb concentration similar to unsubducted oceanic crust and is therefore not the solution to the problem of the Earth's "missing" Nb.

  8. Effects of macronutrient additions on nickel uptake and distribution in the dinoflagellate Prorocentrum donghaiense Lu.

    PubMed

    Hong, Hua-Sheng; Wang, Ming-Hua; Huang, Xu-Guang; Wang, Da-Zhi

    2009-06-01

    The influences of macronutrient additions on nickel (Ni) uptake and distribution in the subcellular structures and macromolecular components of the dinoflagellate Prorocentrum donghaiense Lu were examined using a radioisotope tracer method. The results showed that nitrate addition enhanced the uptake of Ni by P. donghaiense, whereas phosphate addition inhibited Ni uptake at high-Ni concentration. Nitrate or phosphate addition significantly affected Ni distribution in the subcellular structures and components. The majority of Ni was found in the soluble substances (>70%) and in the proteins (55.0-79.6%) of the algal cells. Urea reduced the Ni content in the amino acid-carbohydrate but elevated its content in proteins, and shown significantly correlated with the protein content of the algal cells. Thus, nutrient enrichment could influence both metal uptake and its distribution in the subcellular structures and components of the phytoplankton, as well as its subsequent transfer in marine food chains. PMID:19217194

  9. Nanopatterned PMMA-Yb:Er/Tm:Lu2O3 composites with visible upconversion emissions.

    PubMed

    Han, X; Maiz, J; Mijangos, C; Zaldo, C

    2014-05-23

    Nanopillars, nanotubes and nanofibers of transparent polymethyl methacrylate (PMMA) polymer with Yb:Ln:Lu2O3 (Ln = Er or Tm) nanoparticles (NPs) (≈30-35 nm average size) have been prepared by infiltration of anodized aluminum oxide hexagonally nanopatterned templates. The outer diameter of these nanostructures is in the 330-400 nm range, with lengths up to 50 μm and a period distance of 430 nm. These nanostructures show visible upconversion (UC) emissions under excitation with 978 nm light. The steady state temperature of the polymer nanostructures is optically evidenced by the Er(3+) UC emission and optically controlled around the PMMA glass transition temperature by the excitation light, introducing a new method for NP storage in a solid and potential optically induced particle release. Full color emission is shown in tridoped (Yb:Er:Tm) samples. PMID:24784527

  10. Three-dimensional calculation of supersonic reacting flows using an LU scheme

    NASA Technical Reports Server (NTRS)

    Yu, Sheng-Tao; Tsai, Y-L Peter; Shuen, Jian-Shun

    1989-01-01

    A new three-dimensional numerical program incorporated with comprehensive real gas property models was developed to simulate supersonic reacting flows. The code employs an implicit finite volume, Lower-Upper (LU) time-marching method to solve the complete Navier-Stokes and species equations in a fully-coupled and very efficient manner. A chemistry model with nine species and eighteen reaction steps are adopted in the program to represent the chemical reaction of H2 and air. To demonstrate the capability of the program, flow fields of underexpanded hydrogen jets transversely injected into supersonic air stream inside the combustors of scramjets are calculated. Results clearly depict the flow characteristics, including the shock structure, separated flow regions around the injector, and the distribution of the combustion products.

  11. Three-dimensional calculation of supersonic reacting flows using an LU scheme

    NASA Technical Reports Server (NTRS)

    Yu, Sheng-Tao; Tsai, Y.-L. Peter (Editor); Shuen, Jian-Shun

    1989-01-01

    A new three-dimensional numerical program incorporated with comprehensive real gas property models has been developed to simulate supersonic reacting flows. The code employs an implicit finite volume, Lower-Upper (LU) time-marching method to solve the complete Navier-Stokes and species equations in a fully-coupled and very efficient manner. A chemistry model with nine species and eighteen reaction steps are adopted in the program to represent the chemical reaction of H2 and air. To demonstrate the capability of the program, flow fields of underexpanded hydrogen jets transversely injected into supersonic air stream inside the combustors of scramjets are calculated. Results clearly depict the flow characteristics, including the shock structure, separated flow regions around the injector, and the distribution of the combustion products.

  12. Three-dimensional calculations of supersonic reacting flows using an LU scheme

    NASA Technical Reports Server (NTRS)

    Yu, Sheng-Tao; Tsai, Y.-L. Peter; Shuen, Jian-Shun

    1991-01-01

    A 3-D numerical program that incorporates comprehensive real gas property models was developed to simulate supersonic reacting flows. The code employs an implicit, finite volume, Lower-Upper (LU), time-marching method to solve the complete Navier-Stokes and species equations in a fully-coupled and efficient manner. A chemistry model with 9 species and 18 reaction steps is adopted in the program to represent the chemical reactions of H2 and air. To demonstrate the capability of the program, flow fields of underexpanded hydrogen jets transversely injected into the supersonic airstream inside the combustors of scramjets are calculated. Results clearly depict the flow characteristics, including the shock structure, the separated flow regions around the injector, and the distribution of the combustion products.

  13. Charge Order, Dynamics, and Magnetostructural Transition in Multiferroic LuFe2O4

    SciTech Connect

    Xu, S. U.; Angst, Manuel; Brinzari, T. V.; Hermann, Raphael P.; Musfeldt, J. L.; Christianson, Andrew D; Mandrus, David; Mcgill, S.; Kim, J.-W.; Islam, Z.

    2008-01-01

    The cascade of temperature and field-driven transitions in LuFe<2/>O<4/> was investigated byM Nossbauer and optical spectroscopies, magnetization, and x-ray scattering. A correlation of Fe2+ Fe3+ charge transfer excitations with the 320 K phase transition below which uperstructure reflections appear confirms its association with gradual charge carrier freezing. Fe2+ on-site excitations are sensitive to the 175 K magnetic transition, which Bragg splitting and large magneto optical contrast suggest involes a monoclinic distortion that can be driven by both temperature and magnetic field. PACS numbers: 71.30.+h,75.30.Kz,78.20.Ci,76.70.+y

  14. 57Fe Mössbauer study of Lu2Fe3Si5 iron silicide superconductor

    DOE PAGES

    Ma, Xiaoming; Ran, Sheng; Pang, Hua; Li, Fashen; Canfield, Paul C.; Bud'ko, Sergey L.

    2015-08-01

    With the advent of Fe–As based superconductivity it has become important to study how superconductivity manifests itself in details of 57Fe Mössbauer spectroscopy of conventional, Fe-bearing superconductors. The iron-based superconductor Lu2Fe3Si5 has been studied by 57Fe Mössbauer spectroscopy over the temperature range from 4.4 K to room temperature with particular attention to the region close to the superconducting transition temperature (Tc=6.1 K). Consistent with the two crystallographic sites for Fe in this structure, the observed spectra appear to have a pattern consisting of two doublets over the whole temperature range. Furthermore, the value of Debye temperature was estimated from temperaturemore » dependence of the isomer shift and the total spectral area and compared with the specific heat capacity data. Neither abnormal behavior of the hyperfine parameters at or near Tc, nor phonon softening were observed.« less

  15. Optically stimulated luminescence (OSL) of Lu 2SiO 5:Ce powder: A preliminary study

    NASA Astrophysics Data System (ADS)

    Gartia, R. K.; Singh, Th. Tejkumar; Singh, Th. Basanta

    2011-01-01

    Optically stimulated luminescence (OSL) of Lu 2SiO 5:Ce powder (Phosphor Technology Ltd., UK) has been measured by Risø TL/OSL Reader (TL-DA-15). Upon blue photon stimulation ( λex ˜470 nm) the material shows strong OSL signal that can detect β-irradiation right up to the dose of ˜0.2 Gy. A brief discussion on this finding is presented by comparing the thermoluminescence of the system with and without optical stimulation. The two key important parameters namely, trap-depth ( E) and frequency factor ( s) of the main peaks that occur at 85 and 232 °C are determined.

  16. Relativistic correlating basis sets for lanthanide atoms from Ce to Lu.

    PubMed

    Sekiya, Masahiro; Noro, Takeshi; Miyoshi, Eisaku; Osanai, You; Koga, Toshikatsu

    2006-03-01

    Contracted Gaussian-type function (CGTF) sets for the description of the 4f subshell correlation and of the 6s and 5d subshell correlation are developed for lanthanide atoms from Ce to Yb. Also prepared are basis sets for the 5d orbitals, which are vacant in the ground states of most lanthanide atoms but are essential in molecular environments. In addition, correlating CGTF sets for the 4f subshell correlation are supplemented for the Lu atom. A segmented contraction scheme is employed for their compactness and efficiency. Contraction coefficients and exponents are determined by minimizing the deviation from accurate natural orbitals generated from configuration interaction calculations that include relativistic effects through the third-order Douglas-Kroll approximation. All-electron and model core potential calculations with the present correlating sets are performed on the ground state of the diatomic CeO molecule. The calculated spectroscopic constants are in good agreement with experimental values. PMID:16419148

  17. Thermoelectric properties of binary LnN (Ln=La and Lu): First principles study

    NASA Astrophysics Data System (ADS)

    Sreeparvathy P., C.; Gudelli, Vijay Kumar; Kanchana, V.; Vaitheeswaran, G.; Svane, A.; Christensen, N. E.

    2015-06-01

    First principles density functional calculations were carried out to study the electronic structure and thermoelectric properties of LnN (Ln = La and Lu) using the full potential linearized augmented plane wave (FP-LAPW) method. The thermoelectric properties were calculated by solving the Boltzmann transport equation within the constant relaxation time approximation. The obtained lattice parameters are in good agreement with the available experimental and other theoretical results. The calculated band gaps using the Tran-Blaha modified Becke-Johnson potential (TB-mBJ), of both compounds are in good agreement with the available experimental values. Thermoelectric properties like thermopower (S), electrical conductivity scaled by relaxation time (σ/τ) and power-factor (S2σ/τ) are calculated as functions of the carrier concentration and temperature for both compounds. The calculated thermoelectric properties are compared with the available experimental results of the similar material ScN.

  18. Targeted Radionuclide Therapy with A 177Lu-labeled Anti-HER2 Nanobody

    PubMed Central

    D'Huyvetter, Matthias; Vincke, Cécile; Xavier, Catarina; Aerts, An; Impens, Nathalie; Baatout, Sarah; De Raeve, Hendrik; Muyldermans, Serge; Caveliers, Vicky; Devoogdt, Nick; Lahoutte, Tony

    2014-01-01

    RIT has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. Smaller radiolabeled antibody fragments and peptides feature highly specific target accumulation, resulting in low accumulation in healthy tissue, except for the kidneys. Nanobodies are the smallest (MW < 15 kDa) functional antigen-binding fragments that are derived from heavy chain-only camelid antibodies. Here, we show that the extend of kidney retention of nanobodies is predominantly dictated by the number of polar residues in the C-terminal amino acid tag. Three nanobodies were produced with different C-terminal amino-acid tag sequences (Myc-His-tagged, His-tagged, and untagged). Dynamic planar imaging of Wistar rats with 111In-DTPA-nanobodies revealed that untagged nanobodies showed a 70 % drop in kidney accumulation compared to Myc-His-tagged nanobodies at 50 min p.i.. In addition, coinfusion of untagged nanobodies with the plasma expander Gelofusin led to a final reduction of 90 %. Similar findings were obtained with different 177Lu-DTPA-2Rs15d nanobody constructs in HER2pos tumor xenografted mice at 1 h p.i.. Kidney accumulation decreased 88 % when comparing Myc-His-tagged to untagged 2Rs15d nanobody, and 95 % with a coinfusion of Gelofusin, without affecting the tumor targeting capacity. Consequently, we identified a generic method to reduce kidney retention of radiolabeled nanobodies. Dosimetry calculations of Gelofusin-coinfused, untagged 177Lu-DTPA-2Rs15d revealed a dose of 0.90 Gy/MBq that was delivered to both tumor and kidneys and extremely low doses to healthy tissues. In a comparative study, 177Lu-DTPA-Trastuzumab supplied 6 times more radiation to the tumor than untagged 177Lu-DTPA-2Rs15d, but concomitantly also a 155, 34, 80, 26 and 4180 fold higher radioactivity burden to lung, liver, spleen, bone and blood. Most importantly, nanobody-based targeted radionuclide

  19. Diode-side-pumped, passively Q-switched Yb:LuAG laser

    NASA Astrophysics Data System (ADS)

    Kaskow, Mateusz; Galecki, Lukasz; Jabczynski, Jan K.; Skorczakowski, Marek; Zendzian, Waldemar; Sulc, Jan; Nemec, Michal; Jelinkova, Helena

    2015-10-01

    A high-gain, diode-side-pumped Yb:LuAG slab laser was designed and investigated for use at room temperature. Pumping occurred from a fast-axis collimated 2D laser diode stack emitting at a wavelength of 970 nm, with 0.8 J over a duration of 0.8 ms. The pump scheme, which enabled efficient mode matching and high gain, was analysed and experimentally verified for different dopant levels. An energy of 100 mJ with 23% slope efficiency in a near fundamental mode was achieved in the free-running regime. A peak power of 2.5 MW and a pulse energy of 10.1 mJ were demonstrated in passive Q-switching by means of a Cr:YAG saturable absorber with 39% initial transmission. The study defined the indications for optimizing such a system.

  20. Aminocarboxylate complexes and octreotide complexes with no carrier added 177Lu, 166Ho and 149Pm.

    PubMed

    Li, Wen Ping; Smith, C Jeff; Cutler, Cathy S; Hoffman, Timothy J; Ketring, Alan R; Jurisson, Silvia S

    2003-04-01

    Several aminocarboxylate complexes of the "no carrier added" (NCA) radiolanthanides (149)Pm, (166)Ho and (177)Lu were evaluated using our in vitro hydroxyapatite and serum stability model and in vivo in normal CF-1 mice [10]. The aminocarboxylate chelates evaluated with the NCA radiolanthanides for in vitro stability were EDTA, CDTA, DTPA, MA-DTPA and DOTA. In addition, the NCA radiolanthanide complexes with DTPA-octreotide (DTPA-OCT) were synthesized and evaluated, as a model for a peptide conjugated aminocarboxylate complex. The biodistribution studies of the NCA complexes with DTPA, DOTA and DTPA-OCT showed that the in vitro model correctly predicted the in vivo stability of the radiolanthanide complexes, with Ln-DOTA > Ln-DTPA > Ln-DTPA-OCT.

  1. Nanopatterned PMMA-Yb:Er/Tm:Lu2O3 composites with visible upconversion emissions

    NASA Astrophysics Data System (ADS)

    Han, X.; Maiz, J.; Mijangos, C.; Zaldo, C.

    2014-05-01

    Nanopillars, nanotubes and nanofibers of transparent polymethyl methacrylate (PMMA) polymer with Yb:Ln:Lu2O3 (Ln = Er or Tm) nanoparticles (NPs) (≈30-35 nm average size) have been prepared by infiltration of anodized aluminum oxide hexagonally nanopatterned templates. The outer diameter of these nanostructures is in the 330-400 nm range, with lengths up to 50 μm and a period distance of 430 nm. These nanostructures show visible upconversion (UC) emissions under excitation with 978 nm light. The steady state temperature of the polymer nanostructures is optically evidenced by the Er3+ UC emission and optically controlled around the PMMA glass transition temperature by the excitation light, introducing a new method for NP storage in a solid and potential optically induced particle release. Full color emission is shown in tridoped (Yb:Er:Tm) samples.

  2. Effect of amplified spontaneous emission on selectivity of laser photoionisation of the 177Lu radioisotope

    NASA Astrophysics Data System (ADS)

    D'yachkov, A. B.; Gorkunov, A. A.; Labozin, A. V.; Mironov, S. M.; Panchenko, V. Ya; Firsov, V. A.; Tsvetkov, G. O.

    2016-06-01

    A significant deselecting effect of amplified spontaneous emission has been observed in the experiments on selective laser photoionisation of the 177Lu radioisotope according to the scheme 5d6s2 2D3/2 → 5d6s6p 4Fo5/2 (18505 cm-1) → 5d6s7s 4D3/2(37194 cm-1) → autoionisation state (53375 cm-1). The effect is conditioned by involvement of non-target isotopes from the lower metastable level 5d6s2 2D5/2(1994 cm-1) into the ionisation process. Spectral filtering of spontaneous emission has allowed us to significantly increase the selectivity of the photoionisation process of the radioisotope and to attain a selectivity value of 105 when using saturating light intensities.

  3. Targeted radionuclide therapy with A 177Lu-labeled anti-HER2 nanobody.

    PubMed

    D'Huyvetter, Matthias; Vincke, Cécile; Xavier, Catarina; Aerts, An; Impens, Nathalie; Baatout, Sarah; De Raeve, Hendrik; Muyldermans, Serge; Caveliers, Vicky; Devoogdt, Nick; Lahoutte, Tony

    2014-01-01

    RIT has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. Smaller radiolabeled antibody fragments and peptides feature highly specific target accumulation, resulting in low accumulation in healthy tissue, except for the kidneys. Nanobodies are the smallest (MW<15 kDa) functional antigen-binding fragments that are derived from heavy chain-only camelid antibodies. Here, we show that the extend of kidney retention of nanobodies is predominantly dictated by the number of polar residues in the C-terminal amino acid tag. Three nanobodies were produced with different C-terminal amino-acid tag sequences (Myc-His-tagged, His-tagged, and untagged). Dynamic planar imaging of Wistar rats with 111In-DTPA-nanobodies revealed that untagged nanobodies showed a 70% drop in kidney accumulation compared to Myc-His-tagged nanobodies at 50 min p.i.. In addition, coinfusion of untagged nanobodies with the plasma expander Gelofusin led to a final reduction of 90%. Similar findings were obtained with different 177Lu-DTPA-2Rs15d nanobody constructs in HER2pos tumor xenografted mice at 1 h p.i.. Kidney accumulation decreased 88% when comparing Myc-His-tagged to untagged 2Rs15d nanobody, and 95% with a coinfusion of Gelofusin, without affecting the tumor targeting capacity. Consequently, we identified a generic method to reduce kidney retention of radiolabeled nanobodies. Dosimetry calculations of Gelofusin-coinfused, untagged 177Lu-DTPA-2Rs15d revealed a dose of 0.90 Gy/MBq that was delivered to both tumor and kidneys and extremely low doses to healthy tissues. In a comparative study, 177Lu-DTPA-Trastuzumab supplied 6 times more radiation to the tumor than untagged 177Lu-DTPA-2Rs15d, but concomitantly also a 155, 34, 80, 26 and 4180 fold higher radioactivity burden to lung, liver, spleen, bone and blood. Most importantly, nanobody-based targeted radionuclide therapy

  4. THE ELASTIC AND THERMODYNAMIC PROPERTIES OF Lu DOPED ScVO3

    NASA Astrophysics Data System (ADS)

    Parveen, Atahar; Gaur, N. K.

    2012-12-01

    We have investigated the elastic, cohesive and thermal properties of (Lu, Sc) VO3 and Sc1-xLuxVO3(0.6 ≤ x ≤ 0.9) perovskites by means of a modified rigid ion model (MRIM). The variation of specific heat is determined following the temperature driven structural phase transitions. Also, the effect of lattice distortions on the elastic and thermal properties of the present pure and doped vanadates has been studied by an atomistic approach. The calculated bulk modulus (BT), reststrahlen frequency (ν0), cohesive energy (ϕ), Debye temperature (θD) and Gruneisen parameter (γ) reproduce well with the corresponding experimental data. The specific heat results can further be improved by including the magnetic ordering contributions to the specific heat.

  5. Lu-177 labelled peptide treatment for radioiodine refractory differentiated thyroid carcinoma.

    PubMed

    Elboğa, Umut; Özkaya, Mesut; Sayiner, Zeynel A; Çelen, Yusuf Zeki

    2016-01-01

    Differentiated thyroid carcinoma (DTC) has good prognosis but 5% of the patients already have distant metastasis at the diagnosis. Tumour cells can lose their iodine uptake ability and enter a state of dedifferentiation. Treatment for differentiated thyroid carcinoma that is not suitable for the local surgery and unresponsive to radioactive iodine uptake is not always easy for physicians. We present a case of a 64-year-old man who had total thyroidectomy surgery and central lymph node dissection with diagnosis of multinodular goitre disease. Histopathological evaluation was papillary thyroid cancer with tall cell variant. Treatment using 150 mCi radioiodine was administered to the patient three times but could not effect a cure. We performed Ga-68 labelled DOTATE (synthetic somatostatin analogue peptide). This provided a good outcome. As evident from our case, Lu-177 radionuclide labelled synthetic somatostatin analogue peptides have therapeutic effect on radioiodine refractory DTC, as an alternative treatment modality. PMID:26957032

  6. Thermoelectric properties of binary LnN (Ln=La and Lu): First principles study

    SciTech Connect

    Sreeparvathy, P. C.; Gudelli, Vijay Kumar; Kanchana, V.; Vaitheeswaran, G.; Svane, A.; Christensen, N. E.

    2015-06-24

    First principles density functional calculations were carried out to study the electronic structure and thermoelectric properties of LnN (Ln = La and Lu) using the full potential linearized augmented plane wave (FP-LAPW) method. The thermoelectric properties were calculated by solving the Boltzmann transport equation within the constant relaxation time approximation. The obtained lattice parameters are in good agreement with the available experimental and other theoretical results. The calculated band gaps using the Tran-Blaha modified Becke-Johnson potential (TB-mBJ), of both compounds are in good agreement with the available experimental values. Thermoelectric properties like thermopower (S), electrical conductivity scaled by relaxation time (σ/τ) and power-factor (S{sup 2}σ/τ) are calculated as functions of the carrier concentration and temperature for both compounds. The calculated thermoelectric properties are compared with the available experimental results of the similar material ScN.

  7. Electronic structure and linear magnetoresistance of the gapless topological insulator PtLuSb

    SciTech Connect

    Shekhar, Chandra; Fecher, Gerhard H.; Kumar Nayak, Ajaya; Felser, Claudia; Ouardi, Siham; Ikenaga, Eiji

    2012-06-18

    The present work reports on the experimental investigation of electronic structure and transport properties of the proposed topological insulator PtLuSb. The electronic structure was investigated by means of polarization dependent hard x-ray photoelectron spectroscopy. The valence band spectra exhibit a linear behavior close to the Fermi energy, as is typical for massless electrons. The transport properties are similar to that of a gapless semiconductor with low carrier concentration. This compound also exhibits an exceptionally high Hall mobility. At low temperatures, the magnetoresistance changes linearly with the applied magnetic field, whereas it exhibits a quadratic nature at high temperatures. A tentative relation between linear magnetoresistance and high mobility is discussed.

  8. Estimation of specific activity of 177Lu by 'saturation assay' principle using DOTA as ligand.

    PubMed

    Pillai, Ambikalmajan M R; Chakraborty, Sudipta; Das, Tapas

    2015-01-01

    Lutetium-177 is a widely used therapeutic radionuclide in targeted therapy and it is important to know its specific activity at the time of radiopharmaceutical preparation, especially for radiolabeling peptides. However, there are no direct methods for the experimental determination of the specific activity which can be readily applied in a hospital radiopharmacy. A new technique based on the 'saturation assay' principle using DOTA as the binding agent for the estimation of specific activity of (177)Lu is reported. The studies demonstrate the proof of principle of this new assay technique. The method is general and can be modified and applied for the estimation of specific activity of other metallic radionuclides by using DOTA or other suitable chelating agents.

  9. Low threshold monocrystalline Nd:(Gd, Lu)2O3 channel waveguide laser.

    PubMed

    Kahn, Andreas; Heinrich, Sebastian; Kühn, Henning; Petermann, Klaus; Bradley, Jonathan D B; Wörhoff, Kerstin; Pollnau, Markus; Huber, Günter

    2009-03-16

    We report the first waveguide laser based on a rare-earth-doped sesquioxide. A 2 microm thick lattice matched Nd(0.5%):(Gd, Lu)(2)O(3) film with a nearly atomically flat surface has been epitaxially grown on a Y(2)O(3) substrate, using pulsed laser deposition. The film has been structured with reactive ion etching and a rib channel waveguide laser has been realized. Laser radiation at 1075 nm and 1079 nm has been observed under 820-nm pumping. The laser possesses a threshold power of about 0.8 mW and a preliminary slope efficiency of 0.5% versus incident pump power. A maximum output power of 1.8 mW has been obtained for 370 mW incident pump power.

  10. Basal plane magnetoelastic stress in magnetic Dy/Y and Er/Lu superlattices

    NASA Astrophysics Data System (ADS)

    del Moral, A.; Ciria, M.; Arnaudas, J. I.; Ward, R. C. C.; Wells, M. R.

    1997-04-01

    The basal plane (bp) cylindrical symmetry breaking magnetoelastic stress (MS), Mγ, has been measured for the series of superlattices (SL) (Dyn/Y15) and (Erm/Lu10), with n=5, 15, 25, and m=10, 20, 30 atomic bp, from 10 K and in applied magnetic fields up to B=12 T, using a capacitive cantilever technique. Field induced transitions are observed. For both series of SLs an effective strong interfacial MS is determined at 10 K and 12 T, up to about one order of magnitude larger and of the opposite sign than the bulk MS. Mγ (12 T) scales with the power m3 of the reduced magnetization m confirming its crystal electric field origin.

  11. Helical antiferromagnetic ordering in Lu1-xScxMnSi

    SciTech Connect

    Goetsch, Ryan J; Anand, V K; Johnston, David C

    2014-08-01

    Polycrystalline samples of Lu1-xScxMnSi (x=0, 0.25, 0.5) are studied using powder x-ray diffraction, heat capacity Cp, magnetization, magnetic susceptibility χ, and electrical resistivity ρ measurements versus temperature T and magnetic field H. This system crystallizes in the primitive orthorhombic TiNiSi-type structure (space group Pnma) as previously reported. The ρ(T) data indicate metallic behavior. The Cp(T), χ(T), and ρ(T) measurements consistently indicate long-range antiferromagnetic (AF) transitions with AF ordering temperatures TN=246, 215, and 188 K for x=0, 0.25, and 0.5, respectively. A second transition is observed at somewhat lower T for each sample from the χ(T) and ρ(T) measurements, which we speculate are due to spin reorientation transitions; these second transitions are completely suppressed in H=5.5 T. The Cp data below 10 K for each composition indicate an enhanced Sommerfeld electronic heat capacity coefficient for the series in the range γ=24–29 mJ/mol K2. The χ(T) measurements up to 1000 K were fitted by local-moment Curie-Weiss behaviors which indicate a low Mn spin S~1. The χ data below TN are analyzed using the Weiss molecular field theory for a planar noncollinear cycloidal AF structure with a composition-dependent pitch, following the previous neutron diffraction work of Venturini et al. [J. Alloys Compd. 256, 65 (1997)]. Within this model, the fits indicate a turn angle between Mn ordered moments along the cycloid axis of ~100° or ~145°, either of which indicate dominant AF interactions between the Mn spins in the Lu1-xScxMnSi series of compounds.

  12. [Thermoluminescence characteristics of Lu2SiO5 : Ce phosphors].

    PubMed

    Wu, Fei; Liu, Xiao-lin; Gu, Mu; Ni, Chen; Huang, Shi-ming; Liu, Bo

    2012-02-01

    To investigate the origin of the thermoluminescence at high temperature, Lu2SiO5 : Ce0.006 (LSO : Ce) phosphors were prepared by sol-gel chemistry in air and graphite respectively. The patterns of X-ray diffraction, excitation and emission spectra and thermoluminescence curves of these samples were analyzed. In comparison with the phosphors prepared in the air, the luminescence intensity was improved and the thermoluminescence peak at 598 K was restrained for the sample prepared in graphite. It was found that the thermoluminescence peak at 598 K was relevant to Ce4+. In order to achieve more evidences, LSO : Ce0.006, K(x) (x = 0.01-0.08) phosphors were prepared. The structures and spectra of K(+) -codoped samples were also studied. By codoping with K+ ions, the luminescence intensity of LSO : Ce phosphor could be enhanced distinctly, but the crystallinity was not improved. The results of the K(+) -codoped LSO: Ce exhibited that K(+) -codoping could improve the concentration of oxygen vacancy and restrain the peak at 598 K. When K+ ion occupied the position of Lu3+, more oxygen vacancies could be created and Ce4+ turned into Ce3+ simultaneously due to the balance of electric charge, which was consistent with the result of the thermoluminescence. So it can also come to the conclusion that the thermoluminescence peak at 598 K was relevant to Ce4+. The reason for K+ ions enhancing the intensity of LSO : Ce can be attributed to the improvement of concentration ratio for Ce3+/Ce4+.

  13. Metallofullerenes encaging mixed-metal clusters: synthesis and structural studies of Gdx Ho3-x N@C80 and Gdx Lu3-x N@C80.

    PubMed

    Zhang, Zhuxia; Liu, Yang; Han, Peide; Zhuang, Shengyi; Wang, Taishan; Luo, Shuchang; Xu, Bingshe

    2015-02-01

    Metallofullerenes of Gdx Ho3-x N@C80 and Gdx Lu3-x N@C80 encapsulating mixed-metal nitride clusters were synthesized. Spectroscopic characterization of Gdx Ho3-x N@C80 and Gdx Lu3-x N@C80 was employed to reveal their structural and vibrational properties. The structural properties of these species were analyzed by using theoretical calculations. The studies of Gdx Ho3-x N@C80 and Gdx Lu3-x N@C80 laid the foundations for these species to be used as multifunctional molecules.

  14. Resolution of Hyperreninemia, Secondary Hyperaldosteronism, and Hypokalemia With 177Lu-DOTATATE Induction and Maintenance Peptide Receptor Radionuclide Therapy in a Patient With Pancreatic Neuroendocrine Tumor.

    PubMed

    Makis, William; McCann, Karey; Riauka, Terence A; McEwan, Alexander J B

    2015-11-01

    A 54-year-old woman presented with a history of nausea, vomiting, diarrhea, and recurrent episodes of severe hypokalemia requiring hospitalization. Imaging revealed a pancreatic mass with liver metastases, histologically confirmed to be a neuroendocrine tumor. Elevated active renin and aldosterone levels were identified, and the patient was treated with 4 induction cycles of Lu-DOTATATE, which resolved the diarrhea, nausea, and hypokalemia, and normalized the renin and aldosterone levels. After 3 additional maintenance Lu-DOTATATE treatments, the pancreatic tumor had decreased in size, was deemed operable, and was resected. She remains on maintenance Lu-DOTATATE therapy with progression-free survival of 45 months thus far.

  15. A novel apatite, Lu5(SiO4)3N:(Ce,Tb), phosphor material: synthesis, structure and applications for NUV-LEDs.

    PubMed

    Guo, Qingfeng; Wang, Qidi; Jiang, Liwei; Liao, Libing; Liu, Haikun; Mei, Lefu

    2016-06-21

    The lutetium containing nitride apatite Lu5(SiO4)3N was prepared by a solid state reaction at high temperature for the first time. Rietveld refinement indicated that the Lu5(SiO4)3N compound has a hexagonal space group of P63/m with cell parameters a = b = 9.700 Å and c = 7.238 Å. Additionally, the results revealed that there are two distinct lutetium sites in the Lu5(SiO4)3N host lattice, i.e. a Lu(1) site with nine coordination (Wyckoff site 4f) and a Lu(2) site with seven coordination (Wyckoff site 6h). Furthermore, the ratio of the number of Lu atoms in Lu(1) and Lu(2) sites is 3 : 2. The band gap for Lu5(SiO4)3N was determined to be 4.12 eV based on the density functional theory (DFT). In the Ce(3+) doped Lu5(SiO4)3N:0.03Ce(3+) compound, the emission peak centered at 462 nm was observed with the Commission International de I'Eclairage (CIE) coordinates of (0.148, 0.184), indicating blue-emission. Remarkably, in Ce(3+) and Tb(3+) co-doped Lu4.97-y(SiO4)3N:0.03Ce(3+),yTb(3+) compounds, the color-tunability was observed with increasing Tb(3+) co-doping rate on moving from blue at Tb(3+) = 0.00 to green at Tb = 0.09, due to the energy transfer from Ce(3+) to Tb(3+) ions being matched well with the decay curve results. Under the excitation at 359 nm, the absolute quantum efficiency (QE) for Lu5(SiO4)3N:0.03Ce(3+) was determined to be 42.13%. This phosphor material could be a platform for modeling a new phosphor and application in the solid-state lighting field. PMID:27165439

  16. Lu.sub.1-xI.sub.3:Ce.sub.x-a scintillator for gamma-ray spectroscopy and time-of-flight pet

    DOEpatents

    Shah, Kanai S.

    2008-02-12

    The present invention includes very fast scintillator materials including lutetium iodide doped with Cerium (Lu.sub.1-xI.sub.3:Ce.sub.x; LuI.sub.3:Ce). The LuI.sub.3 scintillator material has surprisingly good characteristics including high light output, high gamma-ray stopping efficiency, fast response, low cost, good proportionality, and minimal afterglow that the material is useful for gamma-ray spectroscopy, medical imaging, nuclear and high energy physics research, diffraction, non-destructive testing, nuclear treaty verification and safeguards, and geological exploration.

  17. On the question of connections between high-K and low-K states in {sup 180}Ta and {sup 176}Lu

    SciTech Connect

    Dracoulis, G. D.

    2010-08-12

    Possible connections between the high- and low-K states in the odd-odd isotopes {sup 176}Lu and {sup 180}Ta are discussed in the context of photoactivation resonances, and the implications for excitations in a stellar environment. Recent spectroscopic studies using (d, 2n) reactions provide limits on the {gamma}-ray branches expected if proposed intermediate states are correct in {sup 180}Ta and {sup 176}Lu, while Deep-inelastic measurements have observed a definitive set of connections in {sup 176}Lu.

  18. Relationship between the magnetic moment of Lu and the magnetic behavior of (Y{sub y}Lu{sub 1-y})(Co{sub 1-x}Al{sub x}){sub 2} from x-ray absorption spectroscopy and x-ray magnetic circular dichroism

    SciTech Connect

    Chaboy, J.; Piquer, C.; Laguna-Marco, M. A.; Kawamura, N.; Suzuki, M.; Takagaki, M.

    2007-02-01

    We present an x-ray magnetic circular dichroism (XMCD) study performed at both the Co K edge and the Lu L{sub 2,3} edges on (Y{sub y}Lu{sub 1-y})(Co{sub 1-x}Al{sub x}){sub 2} systems. The XMCD spectra reflect the different magnetic character of these systems, allowing us to monitor the transition from weak to strong ferromagnetism. The XMCD at the Lu L{sub 2,3} edges indicates the existence of an ordered 5d moment at the lutetium sites that is coupled antiparallel to the Co moment. Estimates of the magnetic moment of Lu have been obtained by applying the XMCD sum rules. Our results show that there is a correlation between the Lu 5d-induced magnetic moment and the magnetic character of the (Y{sub y}Lu{sub 1-y})(Co{sub 1-x}Al{sub x}){sub 2} compounds. These results suggest that the developing of the Lu moment plays an important role in reinforcing the magnetic interactions and favoring the ferromagnetic character of the Lu-rich compounds.

  19. Spectroscopic and laser characterization of Yb0.15:(LuxY1-x)3Al5O12 ceramics with different Lu/Y balance.

    PubMed

    Pirri, Angela; Toci, Guido; Li, Jiang; Xie, Tengfei; Pan, Yubai; Babin, Vladimir; Beitlerova, Alena; Nikl, Martin; Vannini, Matteo

    2016-08-01

    We report a broad comparative analysis of the spectroscopic and laser properties of solid solution Lutetium-Yttrium Aluminum Garnet (LuYAG, (LuxY1-x)3Al5O12) ceramics doped with Yb. The investigation was mainly aimed to assess the impact of the Lu/Y ratio on the Yb optical and laser properties. Therefore we analyzed a set of samples with different Y/Lu balance, namely 25/75, 50/50 and 75/25, with 15% Yb doping. We found that the Yb absorption and emission spectra changed from YAG to LuAG when gradually increasing in Lu content. Regarding the laser emission, remarkable results were achieved with all samples. Maximum output power was 8.2 W, 7.3 W and 8.7 W for Y/Lu balance 25/75, 50/50 and 75/25 respectively, at 1030 nm; the slope efficiency and the optical-to-optical efficiencies approached or exceeded 60% and 50% respectively. The tuning range was investigated using an intracavity ZnSe prism. The broadest tuning range (998 nm to 1063 nm) was obtained with Y/Lu balance 75/25, whereas the emission of the other two samples extended from 1000 nm to 1058 nm. To the best of our knowledge, this is the first comparative analysis of Yb:LuYAG ceramics or crystals as laser host across such a broad range of Y/Lu ratios. PMID:27505750

  20. A new, simplified procedure, for separating Lu, Hf, Sm, and Nd, in preparation for coupled geochronology by ICP-MS

    NASA Astrophysics Data System (ADS)

    Arauza, S. J.; Kylander-Clark, A. R.; Hacker, B. R.

    2010-12-01

    The ubiquitous presence of garnet at high pressure and its chemical variability with pressure and temperature make garnet a widely-utilized phase for thermobarometric studies. An opportunity to further constrain P-T-t paths with geochronology also arises due to the presence of radiogenic daughter-isotopes (i.e. Hf and Nd) that allow for the use of Lu-Hf and Sm-Nd decay to directly date metamorphic mineral assemblages, which is an advantage over the use of accessory phases. Because of the different distribution coefficients of Lu and Sm in garnet, a coupled-geochronometer approach offers the opportunity to constrain a minimum time-span for garnet stability (Lapen et al. 2003, Kylander-Clark et al. 2007). Unfortunately, the overwhelming abundance of Ti and Zr in dissolved separates results in inaccurate measurements of Hf isotopic concentration (Scherer et al. 2000), necessitating the development of a sophisticated method of elemental separation. Here we present a simple method for the separation of Lu, Hf, Sm, and Nd from whole-rock samples of garnet-bearing rocks that provides a promising separation of Ti and Zr from Hf and sufficient rare-earth element separation for analysis by MC-ICPMS. Bulk chemical separation (REE from major elements) experiments were run using 0.7 x 20 cm glass columns with Dowex 50WX8 ion-exchange resin (200-400 mesh). These columns were run with variable abundances of HCl/HF in variable concentrations to test the ability of these resins to separate Hf from major elements, Ti, Zr, and the REEs from one another. Element concentrations of each aliquot were measured on the Nu Instruments AttoM single collector ICPMS. Results show that Hf is separated best from Ti and Zr when eluted with Lu in 2.5N HCl; Sm is also eluted in the same acid, and Nd is eluted last in 6N HCl. A simple, single-step chemistry further isolates Lu, Hf, Sm and Nd in smaller columns (Bio-Rad polyprep 0.8 x 4 cm), filled with Eichrom Ln-spec resin (50-100 um), via a

  1. Lu-Hf and Sm-Nd geochronology of garnet gneisses in the central Appalachians, U.S.: Implications for the timing and duration of Grenville Orogeny

    NASA Astrophysics Data System (ADS)

    Vervoort, Jeff; Ramsey, Molly; Mulcahy, Sean; Aleinikoff, John; Southworth, Scott

    2014-05-01

    The Grenville orogeny is one of the most significant geological events in Earth's history with remnants of this event prominent on virtually every continent. Constraining its timing and duration is important not only for understanding the tectonics of the Grenville itself, but also for understanding supercontinent cycles and other questions of Earth's evolution. In order to provide better constraints on the timing of Grenvillian metamorphism, we analyzed garnet-bearing Mesoproterozoic ortho and paragneisses, collected along a 150 km transect in the northern Blue Ridge Province, using combined Lu-Hf and Sm-Nd geochronology. The orthogneisses have U-Pb zircon crystallization ages of ~1140 and 1100 Ma. The paragneisses have maximum depositional ages ~1050 to 1020 Ma, based on the youngest detrital zircon populations. Zircon overgrowths and monazite ages suggest metamorphic events between ~1050 and 960 Ma. The Lu-Hf and Sm-Nd data for these samples both yield robust garnet ages with large spread of parent/daughter ratios, low age uncertainties, and low MSWD values. Lu-Hf ages define a narrow time span (1043±12 Ma to 1016±4 Ma; wtd. mean, 1024±7 Ma, 2σ). The Sm-Nd ages, determined on the same solutions as Lu-Hf, also define a narrow time range but are systematically younger (974±11 Ma to 932±5 Ma; wtd. mean, 957±10 Ma). The average difference between Lu-Hf and Sm-Nd ages is 67 Ma; the oldest Sm-Nd age is 40 Ma younger than the youngest Lu-Hf age. These large systematic differences in the ages are enigmatic. While Sm-Nd ages younger than Lu-Hf are not uncommon, these differences are typically small. There are, however, potential explanations for these differences. (1) Lu partitions strongly into garnet during growth resulting in high Lu/Hf ratios in the core and yielding ages weighted toward the beginning of growth (e.g., Skora, 2006); no similar partitioning exists in Sm/Nd and these ages reflect mean garnet growth. (2) Lu diffuses much faster than Hf at elevated

  2. Variable Emission Changes in Bi3+/Ln3+ (Ln = Eu, Sm, Dy) Co-doped Lutetium Vanadates (LuVO4)

    NASA Astrophysics Data System (ADS)

    Zheng, Yuhui; Hu, Jing; Deng, Surong; Gao, Jinwei; Wang, Qianming

    2016-06-01

    High-purity LuVO4: Ln3+/Bi3+ (Ln = Eu, Sm, Dy) phosphors with tetragonal zircon structures were successfully synthesized. The reactions have been carried out by multiple irradiations with very high efficiency. Transmission electron microscope images showed that the phosphors had rod-like structures with average lengths of about 200 nm. The host absorption edge of LuVO4: Ln3+/Bi3+ (Ln = Eu, Sm) shifted to the longer wavelength side. Furthermore, the red emission of Eu3+ ion and the orange emission of Sm3+ ion are remarkably enhanced by encapsulating Bi3+ in LuVO4 system, whereas in the case of LuVO4: Dy3+/Bi3+, the host absorption and the yellow emission from dysprosium have been suppressed in the presence of Bi3+. These novel findings will facilitate their use in the display field.

  3. Electronic and crystalline structures of zero band-gap LuPdBi thin films grown epitaxially on MgO(100)

    SciTech Connect

    Shan, Rong; Ouardi, Siham; Fecher, Gerhard H.; ViolBarbosa, Carlos E.; Felser, Claudia; Gao, Li; Kellock, Andrew; Roche, Kevin P.; Samant, Mahesh G.; Parkin, Stuart S. P.; Ikenaga, Eiji

    2013-04-29

    Thin films of the proposed topological insulator LuPdBi-a Heusler compound with the C1{sub b} structure-were prepared on Ta-Mo-buffered MgO(100) substrates by co-sputtering from PdBi{sub 2} and Lu targets. Epitaxial growth of LuPdBi films was confirmed by X-ray diffraction and reflection high-energy electron diffraction. The root-mean-square roughness of the films was as low as 1.45 nm, even though the films were deposited at high temperature. The film composition is close to the ideal stoichiometric ratio. The valence band spectra of the LuPdBi films, observed by hard X-ray photoelectron spectroscopy, correspond very well with the ab initio-calculated density of states.

  4. Epitaxial growth and structure of (La{sub 1-x}Lu{sub x}){sub 2}O{sub 3} alloys on Si(111)

    SciTech Connect

    Watahiki, T.; Grosse, F.; Braun, W.; Kaganer, V. M.; Proessdorf, A.; Trampert, A.; Riechert, H.

    2010-07-19

    LaLuO{sub 3} layers are epitaxially grown on Si(111) by molecular beam epitaxy using high temperature effusion sources. Samples are prepared by simultaneous as well as alternating growth of La{sub 2}O{sub 3} and Lu{sub 2}O{sub 3}. Grazing incidence x-ray diffraction indicates that the resulting crystal structure of the alloys is cubic. Simultaneous and alternating growth with a monolayer period lead to the same distribution of La and Lu with no preferential ordering. In all cases the lattice mismatch to Si is less than 0.6%. The experimental results are analyzed by studying the energetics of hexagonal, bixbyite, and perovskite (La{sub 1-x}Lu{sub x}){sub 2}O{sub 3} crystal structures employing density functional theory.

  5. Radiosynovectomy of the elbow joint synovitis in rheumatoid arthritis treated with Lutetium - 177 labeled hydroxylapatite (Lu-177 HA) particulates; first case report and image of Lu -177 HA in the elbow joint

    PubMed Central

    Kamaleshwaran, Koramadai Karuppusamy; Rajamani, Venkataraman; Thirumalaisamy, Subbiah Gounder; Chakraborty, Sudipta; Kalarikal, Radhakrishnan; Mohanan, Vyshakh; Shinto, Ajit Sugunan

    2014-01-01

    Rheumatoid arthritis is a chronic disease that is mainly characterized by asymmetric erosive synovitis, particularly affecting the peripheral joints. Radiation synovectomy or radiosynovectomy, also known as radiosynoviorthesis was first described in 1950's as a adjuvant treatment for rheumatoid arthritis. Radiosynovectomy is based on the irradiation of the joint synovium by the intra-articular administration of various β-emitting radiopharmaceuticals. Lu-177 has presence of gamma photons of imagable energy with low abundance which provides the additional benefit of carrying out simultaneous scintigraphy. We describe the first case report of use of Lu-177 hydroxylapatite particulates in a 35-year-old female patient who was presented with elbow joint synovitis due to rheumatoid arthritis. PMID:25400373

  6. Radiosynovectomy of the elbow joint synovitis in rheumatoid arthritis treated with Lutetium - 177 labeled hydroxylapatite (Lu-177 HA) particulates; first case report and image of Lu -177 HA in the elbow joint.

    PubMed

    Kamaleshwaran, Koramadai Karuppusamy; Rajamani, Venkataraman; Thirumalaisamy, Subbiah Gounder; Chakraborty, Sudipta; Kalarikal, Radhakrishnan; Mohanan, Vyshakh; Shinto, Ajit Sugunan

    2014-10-01

    Rheumatoid arthritis is a chronic disease that is mainly characterized by asymmetric erosive synovitis, particularly affecting the peripheral joints. Radiation synovectomy or radiosynovectomy, also known as radiosynoviorthesis was first described in 1950's as a adjuvant treatment for rheumatoid arthritis. Radiosynovectomy is based on the irradiation of the joint synovium by the intra-articular administration of various β-emitting radiopharmaceuticals. Lu-177 has presence of gamma photons of imagable energy with low abundance which provides the additional benefit of carrying out simultaneous scintigraphy. We describe the first case report of use of Lu-177 hydroxylapatite particulates in a 35-year-old female patient who was presented with elbow joint synovitis due to rheumatoid arthritis.

  7. Controlled processing of (Gd,Ln)2O3:Eu (Ln = Y, Lu) red phosphor particles and compositional effects on photoluminescence

    NASA Astrophysics Data System (ADS)

    Lu, Bin; Li, Ji-Guang; Sakka, Yoshio

    2013-12-01

    Synthesis of (Gd0.95-xLnxEu0.05)2O3 (Ln = Y and Lu, x = 0-0.95) powders via ammonium hydrogen carbonate (AHC) precipitation has been systematically studied. The best synthesis parameters are found to be an AHC/total cation molar ratio of 4.5 and an ageing time of 3 h. The effects of Y3+ and Lu3+ substitution for Gd3+, on the nucleation kinetics of the precursors and structural features and optical properties of the oxides, have been investigated. The results show that (i) different nucleation kinetics exist in the Gd-Y-Eu and Gd-Lu-Eu ternary systems, which lead to various morphologies and particle sizes of the precipitated precursors. The (Gd,Y)2O3:Eu precursors display spherical particle morphologies and the particle sizes increase along with more Y3+ addition. The (Gd,Lu)2O3:Eu precursors, on the other hand, are hollow spheres and the particle sizes increase with increasing Lu3+ incorporation, (ii) the resultant oxide powders are ultrafine, narrow in size distribution, well dispersed and rounded in particle shape, (iii) lattice parameters of the two kinds of oxide solid solutions linearly decrease at a higher Y3+ or Lu3+ content. Their theoretical densities linearly decrease with increasing Y3+ incorporation, but increase along with more Lu3+ addition and (iv) the two kinds of phosphors exhibit typical red emissions at ˜613 nm and their charge-transfer bands blue shift at a higher Y3+ or Lu3+ content. Photoluminescence/photoluminescence excitation intensities and external quantum efficiency are found to decrease with increasing value of x, and the fluorescence lifetime mainly depends on the specific surface areas of the powders.

  8. Fabrication and microstructure of cerium doped lutetium aluminum garnet (Ce:LuAG) transparent ceramics by solid-state reaction method

    SciTech Connect

    Li, Junlang; Xu, Jian; Shi, Ying; Qi, Hongfang; Xie, Jianjun; Lei, Fang

    2014-07-01

    Highlights: • We fabricate Ce doped lutetium aluminum garnet ceramics by solid-state method. • The raw materials include Lu{sub 2}O{sub 3} nanopowders synthesized by co-precipitation method. • The density of the transparent ceramics reach 99.7% of the theoretical value. • The optical transmittance of the bulk ceramic at 550 nm was 57.48%. • Some scattering centers decrease the optical characteristic of the ceramic. - Abstract: Polycrystalline Ce{sup 3+} doped lutetium aluminum garnet (Ce:LuAG) transparent ceramics fabricated by one step solid-state reaction method using synthetic nano-sized Lu{sub 2}O{sub 3}, commercial α-Al{sub 2}O{sub 3} and CeO{sub 2} powders were investigated in this paper. The green compacts shaped by the mixed powders were successfully densified into Ce:LuAG transparent ceramics after vacuum sintering at 1750 °C for 10 h. The in-line optical transmittance of the Ce:LuAG ceramic made by home-made Lu{sub 2}O{sub 3} powders could reach 57.48% at 550 nm, which was higher than that of the ceramic made by commercial Lu{sub 2}O{sub 3} powders (22.96%). The microstructure observation showed that light scattering centers caused by micro-pores, aluminum segregation and refraction index inhomogeneities induced the decrease of optical transparency of the Ce:LuAG ceramics, which should be removed and optimized in the future work.

  9. Microstructure, optical, and scintillation characteristics of Pr{sup 3+} doped Lu{sub 3}Al{sub 5}O{sub 12} optical ceramics

    SciTech Connect

    Shi Yun; Feng Xiqi; Shen Yiqiang; Pan Yubai; Liu Qian; Nikl, Martin; Mares, Jiri A.; Beitlerova, A.; Kucerkova, R.

    2011-01-01

    0.5, 1.0, and 5.0 at. %Pr{sup 3+} doped Lu{sub 3}Al{sub 5}O{sub 12} (Pr:LuAG) optical ceramics are fabricated and compared with Bi{sub 4}Ge{sub 3}O{sub 12} (BGO) and Pr:LuAG single crystals as for their optical, luminescence and scintillation properties. Radio-luminescence intensity of the fast UV emission based on 5d{sub 1}{yields}4f Pr{sup 3+} transition reaches up to 20 times of that of BGO single crystal reference scintillator. Photoelectron yield of the best performing 0.5 at. % Pr:LuAG ceramic sample is about 1002 phels/MeV, about 30% lower than that of BGO reference sample and about 65% lower than that of Pr:LuAG single crystal. The trapping phenomena at grain boundaries and/or structural defects are proposed as the main cause of degradation of the scintillation response of the Pr:LuAG optical ceramics.

  10. Improved Near-Infrared Up-Conversion Emission of Tm3+ Sensitized by Yb3+ and Ho3+ in LuF3 Nanocrystals.

    PubMed

    Xu, Xuhui; Wu, Yumei; Bian, Wenjuan; Yu, Xue; Zhang, Buhao; Li, Qianyue; Qiu, Jianbei; Liu, BiTao

    2016-04-01

    In the present work, mono-disperse and uniform orthorhombic lutetium fluoride (LuF3) nanocrystals with an average size of about 35 nm have been successfully synthesized by a simple ionothermal method without any template. The infrared (IR) to visible up-conversion (UC) photoluminescence of LuF3 doped with Yb3+, Tm3+, and Ho3+ under 980 nm excitation was systemically studied. The intensity of near infrared (NIR) to visible up-conversion emission of Tm3+ was improved efficiently by adding Yb3+ and Ho3+ in LuF3, especially for the broad NIR emission band located at 812 nm. Meanwhile, compared to the Yb3+ and Tm3+ co-doped LuF3, the ratio of red to green emission in the Yb3+, TmS+, and HoS+ co-doped LuF3 changed greatly, and a bright yellowish-green emission was observed under 980 nm laser excitation. It shows that Yb3+, Tm3+ and Ho3+ co-doped LuF3 nanocrystals provided a potential application in vitro and in vivo bio-imaging, color displays and optical storage. PMID:27451685

  11. [Xi yuan lu (Records for Washing Away of Wrong Cases) and justice tests in the Republic of China in the context of western knowledge].

    PubMed

    Long, Wei

    2014-09-01

    Xi yuan lu (Records for Washing Away of Wrong Cases) has become the important criterion and authority of the criminal justice tests in the proceedings of case and judicatory judgment, since it was issued royally and officially in the reign of Kangxi Emperor of the Qing Dynasty. However, the Xi yuan lu and its traditional tests was subjected to strong criticism after the introduction of modern science. Especially since the May 4(th) New Culture Movement, not only the theory in the Xi yuan lu had been met with incredulity and condemned sharply through western chemical tests by the intelligentsia, but also the traditional methods of justice tests based on the book was fully criticized. Though the Xi yuan lu has fallen down from the altar, the traditional methods in the book still were used in practice in China during 1930s--1940s because the scientific system of forensic medicine was not established yet. Xi yuan lu, though fallen yet not defeated, reveals its deep-rooted life. The modern fate of the Xi yuan lu was not only the direct result of different historical conversation in the different periods of modern time, but also a true picture of modern China.

  12. Jahn-Teller versus quantum effects in the spin-orbital material LuVO3

    SciTech Connect

    Skoulatos, M.; Toth, S.; Roessli, B.; Enderle, M.; Habicht, K.; Sheptyakov, D.; Cervellino, A.; Freeman, P. G.; Reehuis, M.; Stunault, A.; McIntyre, G. J.; Tung, L. D.; Marjerrison, C.; Pomjakushina, E.; Brown, P. J.; Khomskii, D. I.; Rüegg, Ch.; Kreyssig, A.; Goldman, A. I.; Goff, J. P.

    2015-04-13

    In this article, we report on combined neutron and resonant x-ray scattering results, identifying the nature of the spin-orbital ground state and magnetic excitations in LuVO3 as driven by the orbital parameter. In particular, we distinguish between models based on orbital-Peierls dimerization, taken as a signature of quantum effects in orbitals, and Jahn-Teller distortions, in favor of the latter. In order to solve this long-standing puzzle, polarized neutron beams were employed as a prerequisite in order to solve details of the magnetic structure, which allowed quantitative intensity analysis of extended magnetic-excitation data sets. The results of this detailed study enabled us to draw definite conclusions about the classical versus quantum behavior of orbitals in this system and to discard the previous claims about quantum effects dominating the orbital physics of LuVO3 and similar systems.

  13. Lu-Hf Analysis of Zircons in the Little Belt Mountains Suggest Paleoproterozoic Subduction in the Great Falls Tectonic Zone

    NASA Astrophysics Data System (ADS)

    Weiss, R. A.; Vogl, J. J.; Mueller, P. A.; Foster, D. A.; Kamenov, G. D.; Wooden, J. L.

    2009-12-01

    In the assembly of Southwestern Laurentia two competing regions have been proposed as the location of a Paleoproterozoic suture between the Archean Wyoming and Hearne provinces; either the Vulcan Structure, located between the Hearne Province and the Medicine Hat Block, or the Great Falls tectonic zone (GFTZ) between the Medicine Hat Block and the Wyoming Province. Due to a general lack of Precambrian exposure in these areas, discerning the true location of the collision has proven challenging, though mounting evidence indicates the GFTZ as the site for this suture. Among this evidence is a Sm-Nd model age of 1.9 Ga for the Little Belt Mountains of the Eastern GFTZ. Samples collected from across multiple units in the Little Belt Mountains have undergone Lu-Hf analysis on individual zircons using laser ablation, MC-ICP-MS. Among these units the Helispot Granite is a recrystallized granite to granodiorite that locally contains strongly foliated, recrystallized porphyroclastic mylonitic textures and has a mean Lu-Hf model age of 1.99 Ga (TDM) with a range of 1.92-2.17 Ga as well as a U-Pb age of 1842 ± 42 Ma. The Cemetery Migmatite is locally banded and derived from igneous components of varied composition with a mean Lu-Hf age of 2.02 Ga (TDM) and a range of 1.85-2.14 Ga as well as a U-Pb age of 1817 ± 16 Ma. The Hoover Ridge Unit is a diverse collection of felsic to mafic intrusives with a mean Lu-Hf age of 2.63 Ga and a range of 2.54-2.88 Ga (TDM) in addition to a U-Pb age of 1846 ± 9 Ma. The Aspen Paragneiss, a migmatitic pelitic paragneiss with local melt layers and injections, has a Lu-Hf age of 2.77 Ga with a range of 2.53-3.19 Ga (TDM). The O’Brien Creek Unit contains fine grained granitic rocks with a mean Lu-Hf model age of 2.21 Ga ranged between 1.59-2.5 Ga (TDM) and a U-Pb age of 1800-1820 Ma. The Sheep Creek Complex contains a collection of granitoids including a sheeted, garnet bearing leucogranite as well as abundant amphibolites. This unit has a

  14. Laser performance of in-band pumped Er : LiYF4 and Er : LiLuF4 crystals

    NASA Astrophysics Data System (ADS)

    Gorbachenya, K. N.; Kurilchik, S. V.; Kisel, V. E.; Yasukevich, A. S.; Kuleshov, N. V.; Nizamutdinov, A. S.; Korableva, S. L.; Semashko, V. V.

    2016-02-01

    Spectroscopic properties of Er : LiLuF4 and Er : LiYF4 crystals in the spectral region near 1.5 μm and the lasing characteristics of these crystals under in-band pumping at a wavelength of 1522 nm are studied. With the Er : LiLuF4 crystal, the maximum slope efficiency with respect to the absorbed pump power was 44% at a wavelength of 1609 nm. Continuous-wave operation of an inband pumped Er : LiYF4 laser is obtained for the first time. The output power at a wavelength of 1606 nm was 58 mW with a slope efficiency of 21%.

  15. Crystallization and preliminary X-ray diffraction analysis of the flax cytokinin oxidase LuCKX1.1

    PubMed Central

    Wan, Li; Williams, Simon J.; Zhang, Xiaoxiao; Ericsson, Daniel J.; Koeck, Markus; Dodds, Peter N.; Ellis, Jeffrey G.; Kobe, Bostjan

    2013-01-01

    The plant hormones cytokinins play a central role in regulating cell division and developmental events. Cytokinin oxidase regulates the levels of these plant hormones by catalyzing their irreversible oxidation, which contributes to the regulation of various morpho-physiological processes controlled by cytokinins. In this study, the crystallization and preliminary X-ray diffraction analysis of the flax cytokinin oxidase LuCKX1.1 are reported. Plate-like crystals of LuCKX1.1 were obtained using PEG 3350 as a precipitant and diffracted X-rays to 1.78 Å resolution. The protein crystals have the symmetry of space group C2 and are most likely to contain two molecules per asymmetric unit. PMID:24100555

  16. Transition from semiconducting to metallic-like conducting and weak antilocalization effect in single crystals of LuPtSb

    SciTech Connect

    Hou, Zhipeng; Wang, Yue; Xu, Guizhou; Zhang, Xiaoming; Liu, Enke; Xi, Xuekui; Wang, Wenhong Wu, Guangheng; Wang, Wenquan; Liu, Zhongyuan

    2015-03-09

    High quality half-Heusler single crystals of LuPtSb have been synthesized by a Pb flux method. The temperature dependent resistivity and Hall effects indicate that the LuPtSb crystal is a p-type gapless semiconductor showing a transition from semiconducting to metallic conducting at 150 K. Moreover, a weakly temperature-dependent positive magnetoresistance (MR) as large as 109% and high carrier mobility up to 2950 cm{sup 2}/V s are experimentally observed at temperatures below 150 K. The low-field MR data show evidence for weak antilocalization (WAL) effect at temperatures even up to 150 K. Analysis of the temperature and angle dependent magnetoconductance manifests that the WAL effect originates from the bulk contribution owing to the strong spin-orbital coupling.

  17. Fast voxel-level dosimetry for (177)Lu labelled peptide treatments.

    PubMed

    Hippeläinen, E; Tenhunen, M; Sohlberg, A

    2015-09-01

    In peptide receptor radionuclide therapy (PRRT), voxel-level radiation absorbed dose calculations can be performed using several different methods. Each method has it strengths and weaknesses; however, Monte Carlo (MC) simulation is presently considered the most accurate method at providing absorbed dose distributions. Unfortunately MC simulation is time-consuming and often impractical to carry out in a clinical practice. In this work, a fast semi-Monte Carlo (sMC) absorbed dose calculation method for (177)Lu PRRT dosimetry is presented. The sMC method is based on a local electron absorption assumption and fast photon MC simulations. The sMC method is compared against full MC simulation code built on PENELOPE (vxlPen) using digital phantoms to assess the accuracy of these assumptions.Due to the local electron absorption assumption of sMC, the potential errors in cross-fire dose from electrons and photons emitted by (177)Lu were first evaluated using an ellipsoidal kidney model by comparing vxlPen and sMC. The photon cross-fire dose from background to kidney and kidney to background with varying kidney-to-background activity concentration ratios were calculated. In addition, kidney to kidney photon and electron cross-dose with different kidney to kidney distances were studied. Second, extended cardiac-torso (XCAT) phantoms were created with liver lesions and with realistic activity distributions and tissue densities. The XCAT phantoms were used to simulate SPECT projections and 3D activity distribution images were reconstructed using an OSEM algorithm. Image-based dose rate distributions were calculated using vxlPen and sMC. Total doses and dose rate volume histograms (DrVH) produced by the two methods were compared.The photon cross-fire dose from the kidney increased the background's absorbed dose by 5% or more up to 5.8 cm distance with 20 : 1 kidney to background activity concentration ratio. On the other hand, the photon cross-fire dose from the background to

  18. Fast voxel-level dosimetry for 177Lu labelled peptide treatments

    NASA Astrophysics Data System (ADS)

    Hippeläinen, E.; Tenhunen, M.; Sohlberg, A.

    2015-09-01

    In peptide receptor radionuclide therapy (PRRT), voxel-level radiation absorbed dose calculations can be performed using several different methods. Each method has it strengths and weaknesses; however, Monte Carlo (MC) simulation is presently considered the most accurate method at providing absorbed dose distributions. Unfortunately MC simulation is time-consuming and often impractical to carry out in a clinical practice. In this work, a fast semi-Monte Carlo (sMC) absorbed dose calculation method for 177Lu PRRT dosimetry is presented. The sMC method is based on a local electron absorption assumption and fast photon MC simulations. The sMC method is compared against full MC simulation code built on PENELOPE (vxlPen) using digital phantoms to assess the accuracy of these assumptions. Due to the local electron absorption assumption of sMC, the potential errors in cross-fire dose from electrons and photons emitted by 177Lu were first evaluated using an ellipsoidal kidney model by comparing vxlPen and sMC. The photon cross-fire dose from background to kidney and kidney to background with varying kidney-to-background activity concentration ratios were calculated. In addition, kidney to kidney photon and electron cross-dose with different kidney to kidney distances were studied. Second, extended cardiac-torso (XCAT) phantoms were created with liver lesions and with realistic activity distributions and tissue densities. The XCAT phantoms were used to simulate SPECT projections and 3D activity distribution images were reconstructed using an OSEM algorithm. Image-based dose rate distributions were calculated using vxlPen and sMC. Total doses and dose rate volume histograms (DrVH) produced by the two methods were compared. The photon cross-fire dose from the kidney increased the background’s absorbed dose by 5% or more up to 5.8 cm distance with 20 : 1 kidney to background activity concentration ratio. On the other hand, the photon cross-fire dose from the background to

  19. Fast voxel-level dosimetry for (177)Lu labelled peptide treatments.

    PubMed

    Hippeläinen, E; Tenhunen, M; Sohlberg, A

    2015-09-01

    In peptide receptor radionuclide therapy (PRRT), voxel-level radiation absorbed dose calculations can be performed using several different methods. Each method has it strengths and weaknesses; however, Monte Carlo (MC) simulation is presently considered the most accurate method at providing absorbed dose distributions. Unfortunately MC simulation is time-consuming and often impractical to carry out in a clinical practice. In this work, a fast semi-Monte Carlo (sMC) absorbed dose calculation method for (177)Lu PRRT dosimetry is presented. The sMC method is based on a local electron absorption assumption and fast photon MC simulations. The sMC method is compared against full MC simulation code built on PENELOPE (vxlPen) using digital phantoms to assess the accuracy of these assumptions.Due to the local electron absorption assumption of sMC, the potential errors in cross-fire dose from electrons and photons emitted by (177)Lu were first evaluated using an ellipsoidal kidney model by comparing vxlPen and sMC. The photon cross-fire dose from background to kidney and kidney to background with varying kidney-to-background activity concentration ratios were calculated. In addition, kidney to kidney photon and electron cross-dose with different kidney to kidney distances were studied. Second, extended cardiac-torso (XCAT) phantoms were created with liver lesions and with realistic activity distributions and tissue densities. The XCAT phantoms were used to simulate SPECT projections and 3D activity distribution images were reconstructed using an OSEM algorithm. Image-based dose rate distributions were calculated using vxlPen and sMC. Total doses and dose rate volume histograms (DrVH) produced by the two methods were compared.The photon cross-fire dose from the kidney increased the background's absorbed dose by 5% or more up to 5.8 cm distance with 20 : 1 kidney to background activity concentration ratio. On the other hand, the photon cross-fire dose from the background to

  20. Distinct microRNA Expression Profiles in Mouse Renal Cortical Tissue after 177Lu-octreotate Administration

    PubMed Central

    Schüler, Emil; Parris, Toshima Z.; Helou, Khalil; Forssell-Aronsson, Eva

    2014-01-01

    Aim The aim of this study was to investigate the variation of the miRNA expression levels in normal renal cortical tissue after 177Lu-octreotate administration, a radiopharmaceutical used for treatment of neuroendocrine cancers. Methods Female BALB/c nude mice were i.v. injected with 1.3, 3.6, 14, 45, or 140 MBq 177Lu-octreotate, while control animals received saline. The animals were killed at 24 h after injection and total RNA, including miRNA, was extracted from the renal cortical tissue and hybridized to the Mouse miRNA Oligo chip 4plex to identify differentially regulated miRNAs between exposed and control samples. Results In total, 57 specific miRNAs were differentially regulated in the exposed renal cortical tissues with 1, 29, 21, 27, and 31 miRNAs identified per dose-level (0.13, 0.34, 1.3, 4.3, and 13 Gy, respectively). No miRNAs were commonly regulated at all dose levels. miR-194, miR-107, miR-3090, and miR-3077 were commonly regulated at 0.34, 1.3, 4.3, and 13 Gy. Strong effects on cellular mechanisms ranging from immune response to p53 signaling and cancer-related pathways were observed at the highest absorbed dose. Thirty-nine of the 57 differentially regulated miRNAs identified in the present study have previously been associated with response to ionizing radiation, indicating common radiation responsive pathways. Conclusion In conclusion, the 177Lu-octreotate associated miRNA signatures were generally dose-specific, thereby illustrating transcriptional regulation of radiation responsive miRNAs. Taken together, these results imply the importance of miRNAs in early immunological responses in the kidneys following 177Lu-octreotate administration. PMID:25386939

  1. Q-switched Ho:Lu2O3 laser at 2.12 μm.

    PubMed

    Lamrini, Samir; Koopmann, Philipp; Scholle, Karsten; Fuhrberg, Peter

    2013-06-01

    We report on a Q-switched Ho:Lu2O3 laser resonantly pumped by a GaSb-based laser diode stack at 1.9 μm. The maximum output energy extracted from the compact plano-plano acousto-optically Q-switched resonator was 8 mJ at a 100 Hz pulse repetition rate, while the peak power was 40 kW. The laser wavelength was 2.124 μm.

  2. Grey scale memory in an optically addressed spatial light modulator with a Lu(Pc)2 doped layer

    NASA Astrophysics Data System (ADS)

    Guéna, M.; Wu, Z. Y.; L'Her, M.; Pondaven, A.; Cadiou, C.

    1998-02-01

    An optically addressed spatial light modulator with electrolyte bisphtalocyanine of lutetium incorporated in the alignment layer is shown to be capable of memorizing a grey scale image. The relationship between the memorized grey scale and the illumination is shown. The temperature, the concentration of Lu(Pc)2 and the spontaneous polarization of liquid crystals are found to have the effect on the memorization rate.

  3. Continuous wave channel waveguide lasers in Nd:LuVO4 fabricated by direct femtosecond laser writing.

    PubMed

    Ren, Yingying; Dong, Ningning; Macdonald, John; Chen, Feng; Zhang, Huaijin; Kar, Ajoy K

    2012-01-30

    Buried channel waveguides in Nd:LuVO<4 were fabricated by femtosecond laser writing with the double-line technique. The photoluminescence properties of the bulk materials were found to be well preserved within the waveguide core region. Continuous-wave laser oscillation at 1066.4 nm was observed from the waveguide under ~809 nm optical excitation, with the absorbed pump power at threshold and laser slope efficiency of 98 mW and 14%, respectively.

  4. Correlation consistent basis sets for lanthanides: The atoms La-Lu

    NASA Astrophysics Data System (ADS)

    Lu, Qing; Peterson, Kirk A.

    2016-08-01

    Using the 3rd-order Douglas-Kroll-Hess (DKH3) Hamiltonian, all-electron correlation consistent basis sets of double-, triple-, and quadruple-zeta quality have been developed for the lanthanide elements La through Lu. Basis sets designed for the recovery of valence correlation (defined here as 4f5s5p5d6s), cc-pVnZ-DK3, and outer-core correlation (valence + 4s4p4d), cc-pwCVnZ-DK3, are reported (n = D, T, and Q). Systematic convergence of both Hartree-Fock and correlation energies towards their respective complete basis set (CBS) limits are observed. Benchmark calculations of the first three ionization potentials (IPs) of La through Lu are reported at the DKH3 coupled cluster singles and doubles with perturbative triples, CCSD(T), level of theory, including effects of correlation down through the 4s electrons. Spin-orbit coupling is treated at the 2-component HF level. After extrapolation to the CBS limit, the average errors with respect to experiment were just 0.52, 1.14, and 4.24 kcal/mol for the 1st, 2nd, and 3rd IPs, respectively, compared to the average experimental uncertainties of 0.03, 1.78, and 2.65 kcal/mol, respectively. The new basis sets are also used in CCSD(T) benchmark calculations of the equilibrium geometries, atomization energies, and heats of formation for Gd2, GdF, and GdF3. Except for the equilibrium geometry and harmonic frequency of GdF, which are accurately known from experiment, all other calculated quantities represent significant improvements compared to the existing experimental quantities. With estimated uncertainties of about ±3 kcal/mol, the 0 K atomization energies (298 K heats of formation) are calculated to be (all in kcal/mol): 33.2 (160.1) for Gd2, 151.7 (-36.6) for GdF, and 447.1 (-295.2) for GdF3.

  5. X-ray absorption spectroscopy study on h-LuFeO3 and h-YbFeO3

    NASA Astrophysics Data System (ADS)

    Xu, Xiaoshan; Cao, Shi; Paudel, Tula; Sinha, Kishan; Jiang, Xuanyuan; Wang, Wenbin; Wang, Jian; Tsymbal, Evgeny; Dowben, Peter

    2015-03-01

    We have studied the unoccupied electronic band structure of the hexagonal ferrites h-LuFeO3 and h-YbFeO3 using the absorption spectroscopy obtained with linearly polarized soft X-ray synchrotron radiation. The shapes of the spectra have been analyzed in terms of the splitting of atomic energy levels in various crystal fields corresponding to the local symmetry of the different atomic sites. Significant hybridization between O-2p and various iron and rare earth orbitals (such as Fe-3d, Lu/Yb-5d and Yb-4f) have been observed. The spectral weight contributions to the electronic states near the bottom of the conduction band are found to consist of Fe-3d, Lu/Yb-5d, and Yb-4f as relatively narrow bands, as well as a wide O-2p band covering much of the measured energy range. The results are consistent with the density functional theory calculation including onsite-Coulomb repulsion corrections in terms of Hubbard U. The project was supported by SRC-NRI Center under Task ID 2398.001, by NSF through Nebraska MRSEC DMR-0820521, DMR 0747704, and by Nebraska EPSCoR.

  6. γ-ray irradiation in the early Solar System and the conundrum of the 176Lu decay constant

    NASA Astrophysics Data System (ADS)

    Albarède, Francis; Scherer, Erik E.; Blichert-Toft, Janne; Rosing, Minik; Simionovici, Alexandre; Bizzarro, Martin

    2006-03-01

    When recent geological calibrations of the 176Lu decay constant are used, the 176Lu- 176Hf ages of chondrites are consistently 4% too old (˜4.75 Ga). Here, we suggest that this discrepancy reflects the photoexcitation of the long-lived 176Lu ground state to the short-lived isomeric state ( T1/2 = 3.7 h) by γ-rays irradiating early condensates. Irradiation may have been of solar origin and taking place at the inner edge of the nebular disk. Alternatively, the source of γ-rays could have been one or more supernova(e) exploding in the vicinity of the solar nebula. Such photoexcitation has been experimentally observed, but requires γ-ray photons that have energies in excess of 838 keV. At this stage, we cannot assess whether the Hf isotope composition of the Bulk Silicate Earth differs from that of chondrites, eucrites, and the 4.56 Ga old Martian meteorite ALH84001, and therefore, whether the precursor material for these different planetary bodies received comparable fluences of γ-rays.

  7. Distribution coefficients of 60 elements on TODGA resin: application to Ca, Lu, Hf, U and Th isotope geochemistry.

    PubMed

    Pourmand, Ali; Dauphas, Nicolas

    2010-05-15

    Batch equilibration experiments are conducted to measure the distribution coefficients (K(d)) of a large number of elements in nitric, nitric plus hydrofluoric, and hydrochloric acids on Eichrom TODGA extraction chromatography resin. The K(d)s are used to devise a multi-element extraction scheme for high-precision elemental and isotopic analyses of Ca, Hf, Lu, Th and U in geological materials, using high-purity lithium metaborate (LiBO(2)) flux fusion that allows rapid digestion of even the most refractory materials. The fusion melt, dissolved in nitric acid, is directly loaded to a TODGA cartridge on a vacuum chamber for elemental separation. An Ln-Spec cartridge is used in tandem with TODGA for Lu purification. The entire procedure, from flux digestion to preparation for isotopic analysis, can be completed in a day. The accuracy of the proposed technique is tested by measuring the concentrations of Ca (standard bracketing), Hf, Lu, Th and U (isotope dilution), and the isotopic composition of Hf in geostandards (USNM3529, BCR-2, BHVO-1, AGV-1 and AGV-2). All measurements are in excellent agreement with recommended literature values, demonstrating the effectiveness of the proposed analytical procedure and the versatility of TODGA resin. PMID:20298848

  8. Growth and Characterization of Lu2O3:Eu3+ Thin Films on Single-Crystal Yttria-Doped Zirconia

    NASA Astrophysics Data System (ADS)

    Roy, Sudesna; Topping, Stephen; Sarin, Vinod

    2013-04-01

    Lu2O3 doped with Eu3+ has been established as an excellent scintillator material for numerous applications such as lasers, optical lenses, and radiography. The material is typically manufactured via hot pressing. This process, apart from being prohibitively expensive, can also introduce major structural defects because it requires grinding/polishing to achieve high transparency and spatial resolution. To overcome these process limitations that have restricted the commercial viability of Lu2O3:Eu3+ scintillators, a technique to deposit thin films (1-10 μm) of Lu2O3:Eu3+ has been developed. This investigation characterized the growth of such thin films by radio frequency (RF) magnetron sputtering on single-crystal cubic yttria doped zirconia (YSZ) substrates. At a deposition rate of 3.3 Å/s, the effects of substrate heating and orientation on coating structure property and the resultant effect on performance were evaluated. Additionally, the effect of deposition parameters and growth conditions on the radioluminescence of the coatings, excited by x-rays, was systematically examined.

  9. Expansion of the hexagonal phase-forming region of Lu1-xScxFeO3 by containerless processing.

    PubMed

    Masuno, Atsunobu; Ishimoto, Atsushi; Moriyoshi, Chikako; Kawaji, Hitoshi; Kuroiwa, Yoshihiro; Inoue, Hiroyuki

    2015-10-01

    Hexagonal Lu1-xScxFeO3 (0 ≤ x ≤ 0.8) was directly solidified from an undercooled melt by containerless processing with an aerodynamic levitation furnace. The hexagonal phase-forming region was considerably extended compared to that of the conventional solid-state reaction (x ∼ 0.5). Synchrotron X-ray diffraction measurements revealed that the crystal structure of the hexagonal phase was isomorphous to hexagonal ferroelectric RMnO3 (R = a rare earth ion) with a polar space group of P63cm. As x increased, the a-axis lattice constant decreased linearly, strengthening the antiferromagnetic interaction between the Fe(3+) ions on the a-b plane. Accordingly, the weak ferromagnetic transition temperature increased from 150 K for x = 0 to 175 K for x = 0.7. These transition temperatures were much higher than those of hexagonal Lu1-xScxMnO3. The results indicate that hexagonal Lu1-xScxFeO3 is a suitable alternative magnetic dielectric for use at higher temperatures. PMID:26376708

  10. Superconductivity in Y3Ru4Ge13 and Lu3Os4Ge13: A comparative study

    NASA Astrophysics Data System (ADS)

    Prakash, Om; Thamizhavel, A.; Ramakrishnan, S.

    2014-12-01

    A variety of unconventional superconductors have low carrier density as a common factor. However, the underlying mechanism of superconductivity in such low carrier density systems is not well understood. Besides, small carrier density is an unfavourable component for conventional superconductivity as described by the Bardeen-Cooper-Schrieffer (BCS) theory. Therefore, studying low carrier density systems can lead to a better understanding in such systems. In this paper, we report superconductivity property studies in low carrier density systems, Y3Ru4Ge13 and Lu3Os4Ge13, using various experimental techniques. Single crystals of Y3Ru4Ge13 and Lu3Os4Ge13 have been grown using the Czochralski crystal pulling method in a tetra-arc furnace. The x-ray diffraction experiment reveals that both compounds crystallize in cubic structure (space group Pm3n, no. 223). The transport, magnetization and heat capacity measurements show that Y3Ru4Ge13 single crystal undergoes a superconducting transition at 2.85 K, whereas, Lu3Os4Ge13 becomes superconductor at 3.1 K.

  11. Biokinetics and dosimetry with 177Lu-DOTA-TATE in athymic mice with induced pancreatic malignant tumours

    NASA Astrophysics Data System (ADS)

    Rodríguez-Cortés, J.; de Murphy, C. Arteaga; Ferro-Flores, Ge; Pedraza-López, M.; Murphy-Stack, E.

    Malignant pancreatic tumours induced in athymic mice are a good model for peptide receptor targeted radiotherapy. The objective of this research was to determine biokinetic parameters in mice, in order to estimate the induced pancreatic tumour absorbed doses and to evaluate an `in house' 177Lu-DOTA-TATE radiopharmaceutical as part of preclinical studies for targeted therapy in humans. AR42J murine pancreas cancer cells expressing somatostatin receptors, were implanted in athymic mice (nD22) to obtain biokinetic and dosimetric data of 177Lu-DOTA-TATE. The mean tumour uptake 2 h post injection was 14.76±1.9% I.A./g; kidney and pancreas uptake, at the same time, were 7.27±1.1% I.A./g (1.71±0.90%/organ) and 4.20±0.98% I.A./g (0.42±0.03%/organ), respectively. The mean absorbed dose to tumour, kidney and pancreas was 0.58±0.02 Gy/MBq; 0.23±0.01 Gy/MBq and 0.14±0.01 Gy/MBq, respectively. These studies justify further dosimetric estimations to ensure that 177Lu-DOTA-TATE will act as expected in humans.

  12. [177Lu-DOTA]0-D-Phe1-Tyr3-Octreotide (177Lu-DOTATOC) For Peptide Receptor Radiotherapy in Patients with Advanced Neuroendocrine Tumours: A Phase-II Study

    PubMed Central

    Baum, Richard P.; Kluge, Andreas W.; Kulkarni, Harshad; Schorr-Neufing, Ulrike; Niepsch, Karin; Bitterlich, Norman; van Echteld, Cees J.A.

    2016-01-01

    Purpose: To characterise efficacy and safety of 177Lu-DOTATOC as agent for peptide receptor radiotherapy (PRRT) of advanced neuroendocrine tumours (NET). Patients and methods: Fifty-six subjects with metastasized and progressive NET (50% gastroenteral, 26.8% pancreatic, 23.2% other primary sites) treated consecutively with 177Lu-DOTATOC were analysed retrospectively. Subjects were administered 177Lu-DOTATOC (mean 2.1 cycles; range 1-4) as 7.0GBq (median) doses at three-monthly intervals. Efficacy was analysed using CT and/or MRI according to RECIST 1.1 criteria and results were stratified for the number of administered cycles and the primary tumour origin. Results: In the total NET population (A), median progression-free (PFS) and overall survival (OS) were 17.4 and 34.2 months, respectively, assessed in a follow-up time (mean ± SD) of 16.1 ± 12.4 months. In patients receiving more than one cycle, mean follow-up time was 22.4 ± 11.0 months for all NETs (B) and PFS was 32.0 months for all NETs (B), 34.5 months for GEP-NET (C), and 11.9 months for other NETs (D). Objective response rates (Complete/Partial Responses) were 33.9%, 40.6%, 54.2%, and 0% for A, B, C, and D groups, respectively, while disease control rates in the same were 66.1%, 93.8%, 100%, and 75%. Complete responses (16.1%, 18.8% and 25.0% for groups A, B and C) were high, 78% of which were maintained throughout the follow up. There were no serious adverse events. One case of self-limiting grade 3 myelotoxicity was reported. Although 20% of patients had mild renal insufficiency at baseline, there was no evidence of exacerbated or de novo renal toxicity after treatment. Conclusion: 177Lu-DOTATOC is a novel agent for PRRT with major potential to induce objective tumour responses and sustained disease control in progressive neuroendocrine tumours, even when administered in moderate activities. The observed safety profile suggests a particularly favourable therapeutic index, including in patients with

  13. Photoluminescence and structural characteristics of Lu{sub 2}O{sub 3}:Eu{sup 3+} nanocrystallites in silica matrix

    SciTech Connect

    Sokolnicki, Jerzy

    2007-08-15

    Two silica ceramics were obtained by mixing nanocrystalline Lu{sub 2}O{sub 3}:Eu{sup 3+} with silica sol using the sol-gel technique. The synthesis procedure for both samples differed in the pH of the sol and time of the sol condensation before substrates were mixed together, which implied their different optical properties. The first one has the same spectroscopic properties as Lu{sub 2}O{sub 3}:Eu{sup 3+} nanocrystallites with an exception of small lowering of the charge transfer (CT) band intensity. This feature is preserved up to about 950 deg. C. Above this temperature, nanocrystallites of Lu{sub 2}O{sub 3}:Eu{sup 3+} react with the silica matrix synthesis pyrosilicate (Lu{sub 2}Si{sub 2}O{sub 7}). The Eu{sup 3+} ions occupy only one crystallographic site in the crystal lattice for low concentration of the activator (1%) and two sites for higher concentration (10%). The second sample exhibits different Eu{sup 3+} emission than Lu{sub 2}O{sub 3}:Eu{sup 3+} nanocrystallites and, additionally, a broad band of the matrix originating at the green region of the spectrum. Sintering the sample at higher temperatures leads to disappearance of this broad emission and continuous changes of the Eu{sup 3+} emission because of the progressive conversion of the Lu{sub 2}O{sub 3}:Eu{sup 3+} to pyrosilicate. At 1300 deg. C for both samples, the reaction of synthesis lutetium pyrosilicate is completed. Structural characteristic of the samples is presented and correlate with the decay profile of the Eu{sup 3+} emission. - Graphical abstract: The combination of the solution combustion synthesis and the sol-gel technique allows to obtain a silica ceramic containing nanocrystalline Lu{sub 2}O{sub 3}:Eu{sup 3+}. The sample treated in temperatures up to 950 deg. C exhibits almost the same optical properties as compared to nanocrystalline Lu{sub 2}O{sub 3}:Eu{sup 3+}. The material displays effective red emission under X-ray excitation and no afterglow, and is very promising phosphor

  14. Electric polarization observed in single crystals of multiferroic Lu2MnCoO6

    NASA Astrophysics Data System (ADS)

    Chikara, S.; Singleton, J.; Bowlan, J.; Yarotski, D. A.; Lee, N.; Choi, H. Y.; Choi, Y. J.; Zapf, V. S.

    2016-05-01

    We report electric polarization and magnetization measurements in single crystals of double perovskite Lu2Mn Co O6 using pulsed magnetic fields and optical second harmonic generation in dc magnetic fields. We observe well-resolved magnetic field-induced changes in the electric polarization in single crystals and thereby resolve the question about whether multiferroic behavior is intrinsic to these materials or is an extrinsic feature of polycrystals. We find electric polarization along the crystalline b axis, that is suppressed by applying a magnetic fields along the c axis, and advance a model for the origin of magnetoelectric coupling. We furthermore map the phase diagram using both capacitance and electric polarization to identify regions of ordering and regions of magnetoelectric hysteresis. This compound is a rare example of coupled hysteretic behavior in the magnetic and electric properties. The ferromagneticlike magnetic hysteresis loop that couples to hysteretic electric polarization can be attributed not to ordinary ferromagnetic domains, but to the rich physics of magnetic frustration of Ising-like spins in the axial next-nearest-neighbor interaction model.

  15. Grain size dependent magneto-dielectric studies on Lu3Fe5O12

    NASA Astrophysics Data System (ADS)

    Ashok Kumar, K.; Manimuthu, P.; Ezhilarasi, V. S.; Venkateswaran, C.

    2014-09-01

    Polycrystalline Lu3Fe5O12 ceramics (LFO) with garnet structure were prepared by solid-state reaction method and a part of the sample was ball milled for 15 h (LFO15h) using a high energy ball mill to study the grain size effect. The cubic garnet phase was confirmed for both LFO and LFO15h samples by X-ray diffraction analysis. The magnetic behavior was studied using a Vibrating Sample Magnetometer and it shows a clear hysteresis loop with ferrimagnetic ordering at room temperature for both LFO and LFO15h samples. X-ray photoelectron spectra reveal the presence of single valence state of Fe ions (Fe3+) in the unmilled sample and mixed valence state of Fe ions (i.e., Fe2+ and Fe3+) in the 15 h ball milled sample. Magneto-dielectric (MD) studies that have been carried out using an indigenous magneto-impedance setup show large MD coupling at room temperature for the LFO15 h in comparison to the LFO sample, making it a candidate explorable for applications in magneto dielectric devices.

  16. Two dimension magnetotelluric modeling using finite element method, incomplete lu preconditioner and biconjugate gradient stabilized technique

    NASA Astrophysics Data System (ADS)

    Zukir, Muhammad; Srigutomo, Wahyu

    2016-08-01

    Magnetotelluric (MT) method is a passive geophysical exploration technique utilizing natural electromagnetic source to obtain variation of the electric field and magnetic field on the surface of the earth. The frequency range used in this modeling is 10-4 Hz to 102 Hz. The two-dimensional (2D) magnetotelluric modeling is aimed to determine the value of electromagnetic field in the earth, the apparent resistivity, and the impedance phase. The relation between the geometrical and physical parameters used are governed by the Maxwell's equations. These equations are used in the case of Transverse Electric polarization (TE) and Transverse Magnetic polarization (TM). To calculate the solutions of electric and magnetic fields in the entire domain, the modeling domain is discretized into smaller elements using the finite element method, whereas the assembled matrix of equation system is solved using the Biconjugate Gradient Stabilized (BiCGStab) technique combined with the Incomplete Lower - Upper (ILU) preconditioner. This scheme can minimize the iteration process (computational cost) and is more effective than the Biconjugate Gradient (BiCG) technique with LU preconditions and Conjugate Gradient Square (CGS).

  17. Comparison of Cathodoluminescent and Photoluminescent Emission Spectra of LuPO4 with Different Dopants

    SciTech Connect

    Goedeke, Shawn; Hollerman, William Andrew; Allison, Stephen W; Gray, P A; Lewis, Linda A; Smithwick III, Robert W; Boatner, Lynn A; Glasgow, David C; Wise, H.

    2008-01-01

    The current interest in returning human exploration to the Moon and Mars makes cost-effective and low-mass health monitoring sensors essential for spacecraft development. In space, there are many surface measurements that are required to monitor the condition of the spacecraft including: surface temperature, radiation dose, and impact. Through the use of tailored phosphors, these conditions can be monitored. Practical space-based phosphor sensors will depend heavily upon research investigating the resistance of phosphors to ionizing radiation and their ability to anneal or 'self-heal' from damage caused by ionizing radiation. For the present research, a group of lutetium orthophosphate (LuPO{sub 4}) crystals with dopants including europium, erbium, and neodymium were characterized. Cathodoluminescence (CL) testing was performed using the low energy electron system located at the NASA Marshall Space Flight Center in Huntsville, Alabama. The data were collected using an Ocean Optics HR4000 spectrometer and a fiber optic feed-through. Previous research has shown that increases in both beam energy and current density improved the CL fluorescence yield. While the total electron dose was small, the intention was to maximize the number of irradiated materials. Additionally, these samples were evaluated using a PTI Quantum Master Spectrophotometer to determine the photoluminescence emission spectra.

  18. Agro-pastoral expansion and land use/land cover (LU/LC) change dynamics in Central-western Brazil

    NASA Astrophysics Data System (ADS)

    Sanga-Ngoie, K.; Yoshikawa, S.; Kanae, S.

    2011-12-01

    In Brazil, large-scale land cover changes following extensive deforestations are expected to generate big impacts onto the climate and the environment over this area, with eventually many negative feedbacks on the global scale. Mato Grosso State, located in the central western Brazil, is known to be the Brazilian state with the highest deforestation rate. Land use/land cover (LU/LC) changes have been reported to occur over large areas in this state due to the introduction of large-scale mechanized agriculture, extensive cattle ranching and uncontrolled slash-and-burn cultivation since the 1980s. In this study, we specifically aim at doing more detailed analysis for the causes of deforestation and savannization in this area, with special attention to agriculture and cattle ranching industry at the municipal district level in this state. Using GIS techniques and remotely-sensed NOAA/AVHRR data, we created 5-year Digital Vegetation Model Maps characterizing LU/LC features for every five years during the 1981-2001 periods using the PCA first components of the NOAA/AVHRR multi-spectral data. Our results make it clear that: (1) LU/LC changes among the phases are of the following 3 major types: degradation, recovery or transition; (2) The changes in LU/LC features are concomitant with the advance of cattle ranching and corn production activities toward the northern parts of the state, and with the expansion of soybean production in the central and western Mato Grosso; (3) Most of the agro-pastoral business are found in the southern Mato Grosso where about 46% of the state's deforestation during the 1981-2001 period occurred; (4) Rates of vegetation change are larger over non-inhabited areas (56%), especially in the north, than over the populated zones in the south (42%). Moreover, this work sheds some new light on the patterns of the changes in LU/LC features (deforestation and savannization) for each municipal district of Mato Grosso. In general, the following activities

  19. Studying the luminescence efficiency of Lu2O3:Eu nanophosphor material for digital X-ray imaging applications

    NASA Astrophysics Data System (ADS)

    Kalyvas, N.; Liaparinos, P.; Michail, C.; David, S.; Fountos, G.; Wójtowicz, M.; Zych, E.; Kandarakis, I.

    2012-01-01

    Scintillator materials are widely used in X-ray medical imaging detector applications, coupled with available photoreceptors like radiographic film or photoreceptors suitable for digital imaging like a-Si, charge-coupled devises (CCD), complementary metal-oxide-semiconductors (CMOS) and GaAs). In addition, scintillators can be utilized in non-medical imaging detectors such as industrial detectors for non-destructive testing (NDT) and detectors used for security purposes (i.e. airport luggage control). Image quality and dose burden in the above applications is associated with the amount of optical photons escaping the scintillator as well as the amount of optical photons captured by the photoreceptor. The former is characterized by the scintillator efficiency and the latter by the spectral matching between the emission spectrum of the scintillator and the spectral response of the photoreceptor. Recently, a scintillator material, europium-activated lutetium oxide (Lu2O3:Eu), has shown improved scintillating properties. Lu2O3:Eu samples of compact nanocrystalline non-agglomerated powder were developed in our laboratory using homogeneous precipitation from a water-toluene solution in the presence of polyvinyl alcohol as a surfactant. In order to test their light-emission properties, experimental measurements under the excitation of X-ray spectra with X-ray tube voltages between 50 kVp and 140 kVp were performed. This range of applied voltages is appropriate for X-ray radiology, NDT and security applications. Lu2O3:Eu was evaluated with respect to output yield and spectral compatibility of digital imaging photoreceptors (CCD-based, CMOS-based, amorphous silicon a:Si flat panels, ES20 and GaAs). High light yield and spectral compatibility increase the performance of the medical detector and reduce the dose burden to the personnel involved. In addition a theoretical model was used to determine the values for the Lu2O3:Eu optical photon light propagation parameters. The

  20. uPAR targeted radionuclide therapy with (177)Lu-DOTA-AE105 inhibits dissemination of metastatic prostate cancer.

    PubMed

    Persson, Morten; Juhl, Karina; Rasmussen, Palle; Brandt-Larsen, Malene; Madsen, Jacob; Ploug, Michael; Kjaer, Andreas

    2014-08-01

    The urokinase-type plasminogen activator receptor (uPAR) is implicated in cancer invasion and metastatic development in prostate cancer and provides therefore an attractive molecular target for both imaging and therapy. In this study, we provide the first in vivo data on an antimetastatic effect of uPAR radionuclide targeted therapy in such lesions and show the potential of uPAR positron emission tomography (PET) imaging for identifying small foci of metastatic cells in a mouse model of disseminating human prostate cancer. Two radiolabeled ligands were generated in high purity and specific activity: a uPAR-targeting probe ((177)Lu-DOTA-AE105) and a nonbinding control ((177)Lu-DOTA-AE105mut). Both uPAR flow cytometry and ELISA confirmed high expression levels of the target uPAR in PC-3M-LUC2.luc cells, and cell binding studies using (177)Lu-DOTA-AE105 resulted in a specific binding with an IC50 value of 100 nM in a competitive binding experiment. In vivo, uPAR targeted radionuclide therapy significantly reduced the number of metastatic lesions in the disseminated metastatic prostate cancer model, when compared to vehicle and nontargeted (177)Lu groups (p < 0.05) using bioluminescence imaging. Moreover, we found a significantly longer metastatic-free survival, with 65% of all mice without any disseminated metastatic lesions present at 65 days after first treatment dose (p = 0.047). In contrast, only 30% of all mice in the combined control groups treated with (177)Lu-DOTA-AE105mut or vehicle were without metastatic lesions. No treatment-induced toxicity was observed during the study as evaluated by observing animal weight and H&E staining of kidney tissue (dose-limiting organ). Finally, uPAR PET imaging using (64)Cu-DOTA-AE105 detected all small, disseminated metastatic foci when compared with bioluminescence imaging in a cohort of animals during the treatment study. In conclusion, uPAR targeted radiotherapy resulted in a significant reduction in the number of

  1. Lu-Hf Garnet Geochronology Reveals the Tectonic History of Precambrian Rocks in the Southern Rocky Mountains

    NASA Astrophysics Data System (ADS)

    Aronoff, R.; Andronicos, C.; Vervoort, J. D.; Hunter, R. A.

    2014-12-01

    Lu-Hf garnet dating of Proterozoic rocks of the southwestern United States provides constraints on the timing and geographic extent of metamorphism associated with the Yavapai, Mazatzal, and newly recognized Picuris orogenies. Prior work focusing on U-Pb dating of plutons and Ar geochronology has left the timing of prograde metamorphism ambiguous, particularly in northern New Mexico and southern Colorado. Because the Lu-Hf system dates the onset of garnet growth, it can constrain the timing of the prograde P-T path. Garnet schist samples from central and northern New Mexico exhibit garnet growth restricted to the time period between ~1460 and 1400 Ma. In the Picuris and Manzano mountains, the oldest Lu-Hf garnet ages predate the U-Pb ages of ~1.4 Ga plutons located near the dated samples. This implies that garnet growth, and therefore the onset of amphibolite facies metamorphism, cannot be driven by contact metamorphism, as has been previously inferred. Garnet-bearing samples from the Needle and Wet Mountains in southern Colorado display a range of garnet ages between ~1750 and 1470 Ma. A garnet gneiss from the Needle Mountains in southwestern Colorado yields an age of 1748 Ma, which is consistent with the Yavapai orogeny. This Lu-Hf garnet age has not been reset by contact metamorphism associated with the emplacement of the ~1.4 Ga Eolus batholith. Anatectic garnet in an orthogneiss from the northern Wet Mountains yields an age of 1601 Ma and is interpreted to date partial melting at the close of the Mazatzal orogeny. A 1476 Ma garnet age from the aureole of the 1440 Ma Oak Creek pluton is interpreted to date upper amphibolite facies metamorphism. The age distribution of these samples shows that rocks in Colorado underwent a complex, poly-metamorphic history, while rocks in New Mexico underwent a single progressive metamorphic event. This contrast implies that the boundary between rocks deformed and metamorphosed during the ~1800-1600 Ma Yavapai and Mazatzal

  2. Mantle evolution on Mars: Constraints from Lu-Hf and Sm-Nd isotope systematics of SNC meteorites

    NASA Astrophysics Data System (ADS)

    Scherer, E. E.; Kurahashi, E.; Mezger, K.

    2012-12-01

    The long-lived 176Lu-176Hf and 147Sm-143Nd isotope systems are commonly employed to track the evolution of complementary mantle and crust reservoirs. The four elements involved are refractory and lithophile, and thus their relative abundances are not expected to have been changed by accretion or core formation. Subsequent silicate differentiation processes, however, e.g., the formation of crust by extraction of melts from the mantle, will fractionate Lu/Hf and Sm/Nd. This typically leaves a depleted mantle with higher Lu/Hf and Sm/Nd values than those of the undifferentiated, presumably chondritic parental reservoir. On the other hand, these same values in crustal rocks tend to be lower than those of their source. (Apparent exceptions are the Martian shergottites, which tend to have lower Lu/Hf as expected, but Sm/Nd higher than their presumed sources. Such decoupling of the two isotope systems may be explained by two-stage melting [e.g., 1, 5].) The ensuing chemical variability among secondary and later generation silicate reservoirs causes their isotopic compositions (e.g., 176Hf/177Hf and 143Nd/144Nd) to diverge from that of the bulk silicate planet over hundreds of millions of years. The resulting isotopic diversity preserved (SNC) meteorites is being used to constrain the differentiation history, melting mineralogy, and dynamics of the Martian mantle [e.g., 1-8]. However, interpretations based on the initial isotope compositions of Hf and Nd strongly depend on the accuracy of crystallization ages. The ages of shergottites in particular are debated (e.g., [3,4,7]). To resolve this issue and gain a better understanding of Martian mantle evolution, we are investigating the Lu-Hf and Sm-Nd systematics of bulk SNC meteorites and constructing internal (mineral) isochrons. Eleven bulk Martian meteorites (5 shergottites, 4 nakhlites, and 2 chassignites) were digested without prior leaching in high-pressure autoclaves for 5 days. Initial ɛ176Hf and ɛ143Nd values

  3. Spatial and temporal distribution of Mesozoic adakitic rocks along the Tan-Lu fault, Eastern China: Constraints on the initiation of lithospheric thinning

    NASA Astrophysics Data System (ADS)

    Gu, Hai-Ou; Xiao, Yilin; Santosh, M.; Li, Wang-Ye; Yang, Xiaoyong; Pack, Andreas; Hou, Zhenhui

    2013-09-01

    The Mesozoic tectonics in East China is characterized by significant lithospheric thinning of the North China Craton, large-scale strike-slip movement along the Tan-Lu fault, and regional magmatism with associated metallogeny. Here we address the possible connections between these three events through a systematic investigation of the geochemistry, zircon geochronology and whole rock oxygen isotopes of the Mesozoic magmatic rocks distributed along the Tan-Lu fault in the Shandong province. The characteristic spatial and temporal distributions of high-Mg adakitic rocks along the Tan-Lu fault with emplacement ages of 134-128 Ma suggest a strong structural control for the emplacement of these intrusions, with magma generation possibly associated with the subduction of the Pacific plate in the early Cretaceous. The low-Mg adakitic rocks (127-120 Ma) in the Su-Lu orogenic belt were formed later than the high-Mg adakitic rocks, whereas in the Dabie orogenic belt, most of the low-Mg adakitic rocks (143-129 Ma) were generated earlier than the high-Mg adakitic rocks. Based on available data, we suggest that the large scale strike-slip tectonics of the Tan-Lu fault in the Mesozoic initiated cratonic destruction at the south-eastern margin of the North China Craton, significantly affecting the lower continental crust within areas near the fault. This process resulted in crustal fragments sinking into the asthenosphere and reacting with peridotites, which increased the Mg# of the adakitic melts, generating the high-Mg adakitic rocks. The gravitationally unstable lower continental crust below the Tan-Lu fault in the Su-Lu orogenic belt triggered larger volume delamination of the lower continental crust or foundering of the root.

  4. Comparative efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

    SciTech Connect

    Frost, Sofia H. L.; Frayo, Shani L.; Miller, Brian W.; Orozco, Johnnie J.; Booth, Garrett C.; Hylarides, Mark D.; Lin, Yukang; Green, Damian J.; Gopal, Ajay K.; Pagel, John M.; Bäck, Tom A.; Fisher, Darrell R.; Press, Oliver W.; Afrin, Farhat

    2015-03-18

    Purpose Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice. Methods Parallel experiments evaluating the biodistribution, imaging, dosimetry, therapeutic efficacy, and toxicity were performed in female athymic nude mice bearing either Ramos (Burkitt lymphoma) or Granta (mantle cell lymphoma) xenografts, utilizing an anti-CD20 antibodystreptavidin conjugate (1F5-SA) and an 90Y- or 177Lu-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-biotin second step reagent. Results The two radionuclides displayed comparable biodistributions in tumors and normal organs; however, the absorbed radiation dose delivered to tumor was more than twice as high for 90Y (1.3 Gy/MBq) as for 177Lu (0.6 Gy/MBq). More importantly, therapy with 90Y-DOTAbiotin was dramatically more effective than with 177Lu-DOTA-biotin, with 100% of Ramos xenograft-bearing mice cured with 37 MBq 90Y, whereas 0% were cured using identical amounts of 177Lu-DOTA-biotin. Similar results were observed in mice bearing Granta xenografts, with 80% of the mice cured with 90Y-PRIT and 0

  5. Evaluation of the antioxidant and melanogenesis inhibitory properties of pracparatum mungo (lu-do huang).

    PubMed

    Kao, Yu-Yu; Chuang, Tien-Fu; Chao, Shiou-Huei; Yang, Jo-Hsuan; Lin, Yu-Chuan; Huang, Hui-Yu

    2013-07-01

    Pracparatum mungo (Lu-Do Huang) is a traditional Chinese functional medicine made from the natural fermentation of mung bean (Lǜ Dòu) mixed with other Chinese medicines. It has been recognized as having liver protecting and detoxifying effects. As mung beans have been verified to possess anti-inflammatory, antioxidant, antipyretic, and whitening actions, the present research utilized the in vitro, ex vivo, and in vivo experimental models to investigate the antioxidant and melanin inhibiting effects of P. mungo on the skin. The in vitro experiment revealed that P. mungo methanol extract (PMME) and P. mungo ethanol extract (PMEE) possess the capacity to clear α,α-diphenyl-2-picrylhydrazyl (DPPH) radicals and inhibit tyrosinase activity. The ex vivo experiment indicated that PMEE can promote the growth of MDCK cells and increase the enzymatic activities of superoxide dismutase (SOD) and catalase in MDCK cells. On the other hand, PMME and PMEE can suppress the proliferation of A375 cells, and PMEE can reduce the enzymatic activities of SOD and catalase in A375 cells. The in vivo results showed that P. mungo can enhance the enzymatic performance of SOD, Catalase, and glutathione peroxidase (GPx) in the liver. The results also showed that P. mungo has antioxidant characteristics and can inhibit tyrosinase activity, thereby promoting the growth of skin tissues and suppressing the proliferation of A375 cells, and thus enhancing the effects that the antioxidant enzymatic performance has on the liver. These results can be applied in the development of tyrosinase inhibitors or antioxidants used for the inhibition of melanin biosynthesis or for auto-oxidation in further industrial applications, particularly those relating to functional food or cosmetic compositions.

  6. Evaluation of the Antioxidant and Melanogenesis Inhibitory Properties of Pracparatum Mungo (Lu-Do Huang)

    PubMed Central

    Kao, Yu-Yu; Chuang, Tien-Fu; Chao, Shiou-Huei; Yang, Jo-Hsuan; Lin, Yu-Chuan; Huang, Hui-Yu

    2013-01-01

    Pracparatum mungo (Lu-Do Huang) is a traditional Chinese functional medicine made from the natural fermentation of mung bean (Lǜ Dòu) mixed with other Chinese medicines. It has been recognized as having liver protecting and detoxifying effects. As mung beans have been verified to possess anti-inflammatory, antioxidant, antipyretic, and whitening actions, the present research utilized the in vitro, ex vivo, and in vivo experimental models to investigate the antioxidant and melanin inhibiting effects of P. mungo on the skin. The in vitro experiment revealed that P. mungo methanol extract (PMME) and P. mungo ethanol extract (PMEE) possess the capacity to clear α,α-diphenyl-2-picrylhydrazyl (DPPH) radicals and inhibit tyrosinase activity. The ex vivo experiment indicated that PMEE can promote the growth of MDCK cells and increase the enzymatic activities of superoxide dismutase (SOD) and catalase in MDCK cells. On the other hand, PMME and PMEE can suppress the proliferation of A375 cells, and PMEE can reduce the enzymatic activities of SOD and catalase in A375 cells. The in vivo results showed that P. mungo can enhance the enzymatic performance of SOD, Catalase, and glutathione peroxidase (GPx) in the liver. The results also showed that P. mungo has antioxidant characteristics and can inhibit tyrosinase activity, thereby promoting the growth of skin tissues and suppressing the proliferation of A375 cells, and thus enhancing the effects that the antioxidant enzymatic performance has on the liver. These results can be applied in the development of tyrosinase inhibitors or antioxidants used for the inhibition of melanin biosynthesis or for auto-oxidation in further industrial applications, particularly those relating to functional food or cosmetic compositions. PMID:24716173

  7. Charge ordering, ferroelectric, and magnetic domains in LuFe{sub 2}O{sub 4} observed by scanning probe microscopy

    SciTech Connect

    Yang, I. K.; Jeong, Y. H.; Kim, Jeehoon; Lee, S. H.; Cheong, S.-W.

    2015-04-13

    LuFe{sub 2}O{sub 4} is a multiferroic system which exhibits charge order, ferroelectricity, and ferrimagnetism simultaneously below ∼230 K. The ferroelectric/charge order domains of LuFe{sub 2}O{sub 4} are imaged with both piezoresponse force microscopy (PFM) and electrostatic force microscopy (EFM), while the magnetic domains are characterized by magnetic force microscopy (MFM). Comparison of PFM and EFM results suggests that the proposed ferroelectricity in LuFe{sub 2}O{sub 4} is not of usual displacive type but of electronic origin. Simultaneous characterization of ferroelectric/charge order and magnetic domains by EFM and MFM, respectively, on the same surface of LuFe{sub 2}O{sub 4} reveals that both domains have irregular patterns of similar shape, but the length scales are quite different. The domain size is approximately 100 nm for the ferroelectric domains, while the magnetic domain size is much larger and gets as large as 1 μm. We also demonstrate that the origin of the formation of irregular domains in LuFe{sub 2}O{sub 4} is not extrinsic but intrinsic.

  8. Anomalies in the Young modulus at structural phase transitions in rare-earth cobaltites RBaCo{sub 4}O{sub 7} (R = Y, Tm-Lu)

    SciTech Connect

    Kazei, Z. A. Snegirev, V. V.; Andreenko, A. S.; Kozeeva, L. P.

    2011-08-15

    The elastic properties of rare-earth cobaltites RBaCo{sub 4}O{sub 7} (R = Y, Tm-Lu) have been experimentally studied in the temperature range of 80-300 K. The strong softening of the Young modulus {Delta}E(T)/E{sub 0} Almost-Equal-To -(0.1-0.2) of cobaltites with Lu and Yb ions has been revealed, which is due to the instability of the crystal structure upon cooling and is accompanied by an inverse jump at the second-order structural phase transition. The softening of the Young modulus and the jump at the phase transition decrease by an order of magnitude and the transition temperature T{sub s} and hysteresis {Delta}T{sub s} increase from a compound with Lu to that with Tm. A large softening of the Young modulus at the structural transition in Lu- and Yb cobaltites indicates that the corresponding elastic constant goes to zero, whereas this constant in Tm cobaltite is not a 'soft' mode of the phase transition. It has been found that the structural phase transition in Lu- and Yb cobaltites is accompanied by a large absorption maximum at the phase transition point and an additional maximum in the low-temperature phase and absorption anomalies in Tm cobaltite is an order of magnitude smaller.

  9. Growth of lanthanide-doped LiGdF4 nanoparticles induced by LiLuF4 core as tri-modal imaging bioprobes.

    PubMed

    Zhai, Xuesong; Lei, Pengpeng; Zhang, Peng; Wang, Zhuo; Song, Shuyan; Xu, Xia; Liu, Xiuling; Feng, Jing; Zhang, Hongjie

    2015-10-01

    Multimodal imaging can compensate for the deficiencies and incorporate the advantages of individual imaging modalities. In this paper, we demonstrated the synthesis of core-shell nanocomposites LiLuF4@LiGdF4:Yb,Er/Tm constituted of tetragonal LiLuF4 nanoparticles as core and Yb,Er/Tm-codoped LiGdF4 as shell. LiLuF4@LiGdF4:Yb,Er/Tm nanoparticles display brighter upconversion luminescence (UCL) than NaGdF4:Yb,Er/Tm nanoparticles with the same size under continuous-wave excitation at 980 nm. The active shell layer of LiGdF4:Yb,Er/Tm not only provide the UCL center, but also serve as magnetic resonance (MR) imaging contrast agent. To further improve the UCL intensity, the inert LiGdF4 shell was coated on the LiLuF4@LiGdF4:Yb,Er/Tm nanoparticles. Furthermore, LiLuF4@LiGdF4:Yb,Tm@LiGdF4 nanoparticles have been successfully applied to UCL/X-ray computed tomography (CT)/MR tri-modal imaging on the modal of tumor-bearing mice. PMID:26148475

  10. The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells.

    PubMed

    Kraus, Marianne; Bader, Juergen; Geurink, Paul P; Weyburne, Emily S; Mirabella, Anne C; Silzle, Tobias; Shabaneh, Tamer B; van der Linden, Wouter A; de Bruin, Gerjan; Haile, Sarah R; van Rooden, Eva; Appenzeller, Christina; Li, Nan; Kisselev, Alexei F; Overkleeft, Herman; Driessen, Christoph

    2015-10-01

    Proteasome inhibitor resistance is a challenge for myeloma therapy. Bortezomib targets the β5 and β1 activity, but not the β2 activity of the proteasome. Bortezomib-resistant myeloma cells down-regulate the activation status of the unfolded protein response, and up-regulate β2 proteasome activity. To improve proteasome inhibition in bortezomib-resistant myeloma and to achieve more efficient UPR activation, we have developed LU-102, a selective inhibitor of the β2 proteasome activity. LU-102 inhibited the β2 activity in intact myeloma cells at low micromolar concentrations without relevant co-inhibition of β1 and β5 proteasome subunits. In proteasome inhibitor-resistant myeloma cells, significantly more potent proteasome inhibition was achieved by bortezomib or carfilzomib in combination with LU-102, compared to bortezomib/carfilzomib alone, resulting in highly synergistic cytotoxic activity of the drug combination via endoplasmatic reticulum stress-induced apoptosis. Combining bortezomib/carfilzomib with LU-102 significantly prolonged proteasome inhibition and increased activation of the unfolded protein response and IRE1-a activity. IRE1-α has recently been shown to control myeloma cell differentiation and bortezomib sensitivity (Leung-Hagesteijn, Cancer Cell 24:3, 289-304). Thus, β2-selective proteasome inhibition by LU-102 in combination with bortezomib or carfilzomib results in synergistic proteasome inhibition, activation of the unfolded protein response, and cytotoxicity, and overcomes bortezomib/carfilzomib resistance in myeloma cells in vitro.

  11. Lattice stabilities, mechanical and thermodynamic properties of Al3Tm and Al3Lu intermetallics under high pressure from first-principles calculations

    NASA Astrophysics Data System (ADS)

    Xu-Dong, Zhang; Wei, Jiang

    2016-02-01

    The effects of high pressure on lattice stability, mechanical and thermodynamic properties of L12 structure Al3Tm and Al3Lu are studied by first-principles calculations within the VASP code. The phonon dispersion curves and density of phonon states are calculated by using the PHONONPY code. Our results agree well with the available experimental and theoretical values. The vibrational properties indicate that Al3Tm and Al3Lu keep their dynamical stabilities in L12 structure up to 100 GPa. The elastic properties and Debye temperatures for Al3Tm and Al3Lu increase with the increase of pressure. The mechanical anisotropic properties are discussed by using anisotropic indices AG, AU, AZ, and the three-dimensional (3D) curved surface of Young’s modulus. The calculated results show that Al3Tm and Al3Lu are both isotropic at 0 GPa and anisotropic under high pressure. In the present work, the sound velocities in different directions for Al3Tm and Al3Lu are also predicted under high pressure. We also calculate the thermodynamic properties and provide the relationships between thermal parameters and temperature/pressure. These results can provide theoretical support for further experimental work and industrial applications. Project supported by the Scientific Technology Plan of the Educational Department of Liaoning Province and Liaoning Innovative Research Team in University, China (Grant No. LT2014004) and the Program for the Young Teacher Cultivation Fund of Shenyang University of Technology, China (Grant No. 005612).

  12. Electronic structure of Pc2Lu and (PcAlF)n oriented thin films using angle resolved photoelectron spectroscopy

    NASA Astrophysics Data System (ADS)

    Fahy, M. R.; Fujimoto, H.; Dann, A. J.; Hoshi, H.; Inokuchi, H.; Maruyama, Y.; Willis, M. R.

    1990-04-01

    Ultraviolet photoelectron spectra have been measured for the radical phthalocyanine dimer, Pc2Lu, and the fluorine bridge stacked phthalocyanine polymer (PcAlF)n. Previous workers have shown that both materials can, under appropriate conditions, be prepared in a well characterised, highly oriented thin film form. Thus, samples for this work were prepared by in situ sublimation at very slow evaporation rates onto crystalline substrates to try to maximise the degree of sample orientation. The angle dependence of the spectra were measured and the sample structure subsequently examined using high resolution TEM. The TEM results show that the (PcAlF)n films have a much higher level of orientation than the Pc2Lu films and this is reflected by the angle dependences of the UPS measurements. The spectra for (PcAlF)n are very similar to measurements on most other simple phthalocyanine compounds and have a small angular dependence. The spectra for Pc2Lu show almost no angular dependence. Again the spectra are broadly similar to that of other Pc's with two significant differences, the lowest energy peak is split and the whole spectra is shifted to lower energy. This result will be discussed in terms of simple molecular orbital ideas. The effect of air on the spectra of both materials was examined and the spectra of (PcAlF)n was found to be particularly sensitive. Attempts to determine the position of the lutetium orbitals by varying the light frequency around the lutetium resonance energies was attempted but no significant variation in the spectra was observed.

  13. Prevalence and conditions associated with chronic pelvic pain in women from São Luís, Brazil

    PubMed Central

    Coelho, L.S.C.; Brito, L.M.O.; Chein, M.B.C.; Mascarenhas, T.S.; Costa, J.P.L.; Nogueira, A.A.; Poli-Neto, O.B.

    2014-01-01

    The objective of the present study was to estimate the prevalence of chronic pelvic pain in the community of São Luís, capital of the State of Maranhão, Northeastern Brazil, and to identify independent conditions associated with it. A cross-sectional study was conducted, including a sample of 1470 women older than 14 years predominantly served by the public health system. The interviews were held in the subject's home by trained interviewers not affiliated with the public health services of the municipality. The homes were visited at random according to the city map and the prevalence of the condition was estimated. To identify the associated conditions, the significant variables (P=0.10) were selected and entered in a multivariate analysis model. Data are reported as odds ratio and 95% confidence interval, with the level of significance set at 0.05. The prevalence of chronic pelvic pain was 19.0%. The independent conditions associated with this diagnosis were: dyspareunia (OR=3.94), premenopausal status (OR=2.95), depressive symptoms (OR=2.33), dysmenorrhea (OR=1.77), smoking (OR=1.72), irregular menstrual flow (OR=1.62), and irritative bladder symptoms (OR=1.90). The prevalence of chronic pelvic pain in Sao Luís is high and is associated with the conditions cited above. Guidelines based on prevention and/or early identification of risk factors may reduce the prevalence of chronic pelvic pain in São Luís, Brazil. PMID:25075577

  14. Spatial analysis of deaths from pulmonary tuberculosis in the city of São Luís, Brazil*

    PubMed Central

    Santos-Neto, Marcelino; Yamamura, Mellina; Garcia, Maria Concebida da Cunha; Popolin, Marcela Paschoal; Silveira, Tatiane Ramos dos Santos; Arcêncio, Ricardo Alexandre

    2014-01-01

    OBJECTIVE: To characterize deaths from pulmonary tuberculosis, according to sociodemographic and operational variables, in the city of São Luís, Brazil, and to describe their spatial distribution. METHODS: This was an exploratory ecological study based on secondary data from death certificates, obtained from the Brazilian Mortality Database, related to deaths from pulmonary tuberculosis. We included all deaths attributed to pulmonary tuberculosis that occurred in the urban area of São Luís between 2008 and 2012. We performed univariate and bivariate analyses of the sociodemographic and operational variables of the deaths investigated, as well as evaluating the spatial distribution of the events by kernel density estimation. RESULTS: During the study period, there were 193 deaths from pulmonary tuberculosis in São Luís. The median age of the affected individuals was 52 years. Of the 193 individuals who died, 142 (73.60%) were male, 133 (68.91%) were Mulatto, 102 (53.13%) were single, and 64 (33.16%) had completed middle school. There was a significant positive association between not having received medical care prior to death and an autopsy having been performed (p = 0.001). A thematic map by density of points showed that the spatial distribution of those deaths was heterogeneous and that the density was as high as 8.12 deaths/km2. CONCLUSIONS: The sociodemographic and operational characteristics of the deaths from pulmonary tuberculosis evaluated in this study, as well as the identification of priority areas for control and surveillance of the disease, could promote public health policies aimed at reducing health inequities, allowing the optimization of resources, as well as informing decisions regarding the selection of strategies and specific interventions targeting the most vulnerable populations. PMID:25410843

  15. Conflicting Lu-Hf and Sm-Nd ages in the garnet gneisses of the Central Appalachians, Eastern U.S.: Implications for the timing and duration of Grenville Orogeny and a case for using coupled Lu-Hf and Sm-Nd geochronology

    NASA Astrophysics Data System (ADS)

    Vervoort, J. D.; Ramsey, M.; Aleinikoff, J. N.; Southworth, S.

    2013-12-01

    The Grenville orogeny is one of the most significant geological events in Earth's history with remnants of this event prominent on virtually every continent. Constraining its timing and duration is important not only for understanding the tectonics of the Grenville itself, but also for understanding supercontinent cycles and other questions of Earth's evolution. In order to provide better constraints on the timing of Grenvillian metamorphism, we analyzed garnet-bearing Mesoproterozoic ortho- and paragneisses, collected along a 150 km transect in the northern Blue Ridge Province, using combined Lu-Hf and Sm-Nd geochronology. The orthogneisses have U-Pb zircon crystallization ages of ~1140 and 1100 Ma. The paragneisses have maximum depositional ages ~1050-1020 Ma, based on the youngest detrital zircon populations. Zircon overgrowths and monazite suggest metamorphic events between ~1050 and 960 Ma. The Lu-Hf and Sm-Nd data for these samples both yield robust garnet ages with large spread of parent/daughter ratios, low age uncertainties, and low MSWD values. Lu-Hf ages define a narrow time span (1043×12 Ma to 1016×4 Ma; wtd. mean, 1024×7 Ma, 2σ). The Sm-Nd ages, determined on the same solutions as Lu-Hf, also define a narrow time range but are systematically younger (974×11 Ma to 932×5 Ma; wtd. mean, 957×10 Ma). The average difference between Lu-Hf and Sm-Nd ages is 67 Ma; the oldest Sm-Nd age is 40 Ma younger than the youngest Lu-Hf age. These large systematic differences in the ages are enigmatic. While Sm-Nd ages younger than Lu-Hf are not uncommon, these differences are typically small; nothing of this magnitude has been previously reported. There are, however, potential explanations for these differences. (1) Lu partitions strongly into garnet during growth yielding ages weighted toward the beginning of growth (e.g., Skora, 2006); no similar partitioning exists in Sm-Nd and these ages reflect mean garnet growth. (2) Lu diffuses much faster than Hf at

  16. Transport and superconducting properties of RNi2B2C (R=Y,nLu) single crystals

    NASA Astrophysics Data System (ADS)

    Rathnayaka, K. D. D.; Bhatnagar, A. K.; Parasiris, A.; Naugle, D. G.; Canfield, P. C.; Cho, B. K.

    1997-04-01

    The in-plane resistivity, in-plane absolute thermopower, and upper critical field measurements are reported for single-crystal samples of YNi2B2C and LuNi2B2C superconductors. The in-plane resistivity shows metallic behavior and varies approximately linearly with temperature near room temperature (RT) but shows nearly quadratic behavior in temperature at low temperatures. The YNi2B2C and LuNi2B2C single-crystal samples exhibit large transverse magnetoresistance (~6-8 % at 45 kOe) in the ab plane. The absolute thermopower S(T) is negative from RT to the superconducting transition temperature Tc. Its magnitude at RT is a few times of the value for a typical good metal. S(T) is approximately linear in temperature between ~150 K and RT. Extrapolation to T=0 gives large intercepts (few μV/K) for both samples suggesting the presence of a much larger 'knee' than would be expected from electron-phonon interaction renormalization effects. The upper critical fields for H parallel and perpendicular to the c axis and the superconducting parameters derived from it do not show any anisotropy for the YNi2B2C single-crystal samples in agreement with magnetization and torque magnetometry measurements, but a small anisotropy is observed for the LuNi2B2C single crystals. The analysis shows that these are moderately strong-coupling type-II superconductors (similar to the A-15 compounds) with a value of the electron-phonon coupling parameter λ(0) approximately equal to 1.2 for YNi2B2C and 1.0 for LuNi2B2C, the Ginzburg-Landau coherence length ξ(0) approximately equal to 70 Å, and Hc2(0)~60-70 kOe. The temperature dependence of the upper critical field shows a positive curvature near Tc in disagreement with the Werthamer, Helfand, Hohenberg, and Maki (WHHM) theory but in agreement with a recent solution of the Gor'kov equation using a basis formed by Landau levels (Bahcall); however, the data show a severe disagreement between the observed low-temperature behavior of Hc2(T) and that

  17. An Yb3+-doped Lu2SiO5 mode-locked laser using a reflective graphene oxide absorber

    NASA Astrophysics Data System (ADS)

    Feng, Chao; Liu, Jie; Wang, Yonggang; Zheng, Lihe; Su, Liangbi; Xu, Jun

    2013-06-01

    Reflective graphene oxide played the part of the saturable absorber to achieve a continuous wave mode-locking (CWML) laser based on Yb3+:Lu2SiO5 (Yb:LSO) crystal for the first time. The laser operated at a repetition frequency of 87 MHz at a maximum average output power of 0.95 W with a single pulse energy of 10.9 nJ. A 9.8 ps ultra-short pulse was yielded at 1058 nm with a full width at half maximum (FWHM) of 2.09 nm, corresponding to a peak power of 1.11 kW.

  18. Evidence for chondritic Lu/Hf in the early crust - mantle system from Antarctic and Western Australian Eoarchean zircon

    NASA Astrophysics Data System (ADS)

    Hiess, J.; Bennett, V. C.; Black, L.; Eggins, S. M.

    2009-12-01

    The timing and extent of early continental crust formation and mantle differentiation remain contentious issues in Earth Sciences. Here we report new, SHRIMP U-Pb zircon geochronology (n = 142 spot analyses on 69 grains), combined with LA-MC-ICPMS 176Hf determinations (n = 110 spot analyses on 59 grains), in three well-characterized orthogneiss samples of the Napier Complex (Mt Sones and Gage Ridge), East Antarctica and the Narryer Complex, West Australia. Prior to analysis all crystals were extensively documented by cathodoluminesence, reflected and transmitted light imaging to guide beam placement and to identify zones of magmatic oscillatory growth from metamorphic recrystallisation textures. Each sample records complex 207Pb/206Pb age structures that can extend from Hadean through to the Neoarchean, while displaying concordant, reverse-discordant and normal-discordant behaviour. U-Pb systematics within individual grains can be correlated with distinct variations in their measured Lu and Hf isotopic compositions. These features lead to the presence of multiple Lu/Hf arrays within each rock sample evolving towards progressively un-radiogenic values through time. Highly concordant populations of Eoarchean zircon from each rock represent the intrusive age of their igneous protolith at approximately 3.88, 3.85 and 3.73 Ga. Across all three samples these zircon populations typically record initial ɛHf values that lie within error of the Earth’s chondritic uniform reservoir (calculated using λ176Lu of 1.867×10-11 yr-1 and CHUR parameters of Bouvier et al., 2008, EPSL 273: 48-57). These near-chondritic results are consistent with recent LA-MC-ICPMS 176Hf work on primitive Eoarchean TTG zircon from other cratons (e.g. the Itsaq Complex of Greenland, Hiess et al., 2009, GCA 73: 4489-4516) and together argue against voluminous continental crustal growth or significant mantle Lu/Hf differentiation during the Hadean or Eoarchean on a global scale. Two grains of

  19. Flaviata longa, a new species in Flaviata Lu & Qin and new synonymies in Empoasca (Matsumurasca) Anufriev (Hemiptera: Cicadellidae: Empoascini).

    PubMed

    Xu, Ye; Lu, Si-Han; Qin, Dao-Zheng

    2015-10-02

    A new species of genus Flaviata Lu & Qin, Flaviata longa sp. nov. is described from Yunnan (southwest China). An identification key for males of all known species in this genus is provided. Photographs and illustrations of adults and male genitalia of the new species are also given. New synonymies for two species in the leafhopper subgenus Empoasca (Matsumurasca) Anufriev of Empoascini are proposed: E. (M.) southerni Zhang, 2014 = E. (M.) clypealata Qin & Zhang, 2011; E. (M.) qini Zhang, 2014 = E. (M.) quadrialata Qin & Zhang, 2011.

  20. Efficient Ho:LuLiF4 laser diode-pumped at 1.15 μm.

    PubMed

    Wang, Sheng-Li; Huang, Chong-Yuan; Zhao, Cheng-Chun; Li, Hong-Qiang; Tang, Yu-Long; Yang, Nan; Zhang, Shuai-Yi; Hang, Yin; Xu, Jian-Qiu

    2013-07-15

    We report the first laser operation based on Ho(3+)-doped LuLiF(4) single crystal, which is directly pumped with 1.15-μm laser diode (LD). Based on the numerical model, it is found that the "two-for-one" effect induced by the cross-relaxation plays an important role for the laser efficiency. The maximum continuous wave (CW) output power of 1.4 W is produced with a beam propagation factor of M(2) ~2 at the lasing wavelength of 2.066 μm. The slope efficiency of 29% with respect to absorbed power is obtained.

  1. MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative 177Lu SPECT Applied for Dosimetry of Radiopharmaceutical Therapy.

    PubMed

    Ljungberg, Michael; Celler, Anna; Konijnenberg, Mark W; Eckerman, Keith F; Dewaraja, Yuni K; Sjögreen-Gleisner, Katarina; Bolch, Wesley E; Brill, A Bertrand; Fahey, Frederic; Fisher, Darrell R; Hobbs, Robert; Howell, Roger W; Meredith, Ruby F; Sgouros, George; Zanzonico, Pat; Bacher, Klaus; Chiesa, Carlo; Flux, Glenn; Lassmann, Michael; Strigari, Lidia; Walrand, Stephan

    2016-01-01

    The accuracy of absorbed dose calculations in personalized internal radionuclide therapy is directly related to the accuracy of the activity (or activity concentration) estimates obtained at each of the imaging time points. MIRD Pamphlet no. 23 presented a general overview of methods that are required for quantitative SPECT imaging. The present document is next in a series of isotope-specific guidelines and recommendations that follow the general information that was provided in MIRD 23. This paper focuses on (177)Lu (lutetium) and its application in radiopharmaceutical therapy. PMID:26471692

  2. MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative 177Lu SPECT Applied for Dosimetry of Radiopharmaceutical Therapy.

    PubMed

    Ljungberg, Michael; Celler, Anna; Konijnenberg, Mark W; Eckerman, Keith F; Dewaraja, Yuni K; Sjögreen-Gleisner, Katarina; Bolch, Wesley E; Brill, A Bertrand; Fahey, Frederic; Fisher, Darrell R; Hobbs, Robert; Howell, Roger W; Meredith, Ruby F; Sgouros, George; Zanzonico, Pat; Bacher, Klaus; Chiesa, Carlo; Flux, Glenn; Lassmann, Michael; Strigari, Lidia; Walrand, Stephan

    2016-01-01

    The accuracy of absorbed dose calculations in personalized internal radionuclide therapy is directly related to the accuracy of the activity (or activity concentration) estimates obtained at each of the imaging time points. MIRD Pamphlet no. 23 presented a general overview of methods that are required for quantitative SPECT imaging. The present document is next in a series of isotope-specific guidelines and recommendations that follow the general information that was provided in MIRD 23. This paper focuses on (177)Lu (lutetium) and its application in radiopharmaceutical therapy.

  3. Simultaneous tri-wavelength laser operation at 916, 1086, and 1089 nm of diode-pumped Nd:LuVO4 crystal

    NASA Astrophysics Data System (ADS)

    Shen, Bingjun; Jin, Lihong; Zhang, Jiajia; Tian, Jian

    2016-09-01

    We report a diode-pumped continuous-wave tri-wavelength Nd:LuVO4 laser operating at 916, 1086, and 1089 nm. A theoretical analysis has been introduced to determine the threshold conditions for simultaneous tri-wavelength laser operation. Using a T-shaped cavity, we realized efficient tri-wavelength operation at 4F3/2  →  4I9/2 and 4F3/2  →  4I11/2 transitions for Nd:LuVO4 crystal, simultaneously. The maximum output power was 2.8 W, which included 916, 1086, and 1089 nm, and the optical conversion efficiency was 15.1%. To our knowledge, this is the first work that realizes simultaneous tri-wavelength Nd:LuVO4 laser operation.

  4. Properties of the 5{sup -} state at 839 keV in {sup 176}Lu and the s-process branching at A=176

    SciTech Connect

    Mohr, P.; Bisterzo, S.; Gallino, R.; Kaeppeler, F.; Kneissl, U.; Winckler, N.

    2009-04-15

    The s-process branching at mass number A=176 depends on the coupling between the high-K ground state and a low-lying low-K isomer in {sup 176}Lu. This coupling is based on electromagnetic transitions via intermediate states at higher energies. The properties of the lowest experimentally confirmed intermediate state at 839 keV are reviewed, and the transition rate between low-K and high-K states under stellar conditions is calculated on the basis of new experimental data for the 839-keV state. Properties of further candidates for intermediate states are briefly analyzed. It is found that the coupling between the high-K ground state and the low-K isomer in {sup 176}Lu is at least one order of magnitude stronger than previously assumed, leading to crucial consequences for the interpretation of the {sup 176}Lu/{sup 176}Hf pair as an s-process thermometer.

  5. A diagonally inverted LU implicit multigrid scheme for the 3-D Navier-Stokes equations and a two equation model of turbulence

    NASA Technical Reports Server (NTRS)

    Yokota, Jeffrey W.

    1988-01-01

    An LU implicit multigrid algorithm is developed to calculate 3-D compressible viscous flows. This scheme solves the full 3-D Reynolds-Averaged Navier-Stokes equation with a two-equation kappa-epsilon model of turbulence. The flow equations are integrated by an efficient, diagonally inverted, LU implicit multigrid scheme while the kappa-epsilon equations are solved, uncoupled from the flow equations, by a block LU implicit algorithm. The flow equations are solved within the framework of the multigrid method using a four-grid level W-cycle, while the kappa-epsilon equations are iterated only on the finest grid. This treatment of the Reynolds-Averaged Navier-Stokes equations proves to be an efficient method for calculating 3-D compressible viscous flows.

  6. Lu.sub.1-xI.sub.3:Ce.sub.x--a scintillator for gamma ray spectroscopy and time-of-flight PET

    DOEpatents

    Shah, Kanai S.

    2007-02-06

    The present invention concerns very fast scintillator materials comprising lutetium iodide doped with Cerium (Lu.sub.1-xI.sub.3:Ce.sub.x; LuI.sub.3:Ce). The LuI.sub.3 scintillator material has surprisingly good characteristics including high light output, high gamma ray stopping efficiency, fast response, low cost, good proportionality, and minimal afterglow that the material is useful for gamma ray spectroscopy, medical imaging, nuclear and high energy physics research, diffraction, non-destructive testing, nuclear treaty verification and safeguards, and geological exploration. The timing resolution of the scintillators of the present invention provide compositions capable of resolving the position of an annihilation event within a portion of a human body cross-section.

  7. Modification of nuclear transitions in stellar plasma by electronic processes: K isomers in {sup 176}Lu and {sup 180}Ta under s-process conditions

    SciTech Connect

    Gosselin, G.; Morel, P.; Mohr, P.

    2010-05-15

    The influence of the stellar plasma on the production and destruction of K isomers is studied for the examples {sup 176}Lu and {sup 180}Ta. Individual electromagnetic transitions are enhanced predominantly by nuclear excitation by electron capture, whereas the other mechanisms of electron scattering and nuclear excitation by electron transition give only minor contributions. It is found that individual transitions can be enhanced significantly for low transition energies below 100 keV. Transitions with higher energies above 200 keV are practically not affected. Although one low-energy transition in {sup 180}Ta is enhanced by up to a factor of 10, the stellar transition rates from low-K to high-K states via so-called intermediate states in {sup 176}Lu and {sup 180}Ta do not change significantly under s-process conditions. The s-process nucleosynthesis of {sup 176}Lu and {sup 180}Ta remains essentially unchanged.

  8. Current conduction and resistive switching characteristics of Sm2O3 and Lu2O3 thin films for low-power flexible memory applications

    NASA Astrophysics Data System (ADS)

    Mondal, Somnath; Chueh, Ching-Hao; Pan, Tung-Ming

    2014-01-01

    In this article, the current conduction and resistive switching (RS) behavior in flexible Sm2O3 and Lu2O3 resistive random access memories (ReRAM) are investigated. Amorphous Sm2O3 and Lu2O3 thin films were deposited at room temperature by radio-frequency magnetron sputtering on flexible polyethylene terephthalate substrate. The structural morphologies of the Sm2O3 and Lu2O3 thin films strongly depend on the lattice energy of the oxides. The dominant current conduction mechanism in the oxide layer changes from electrode control Schottky emission in Sm2O3 to bulk controlled space-charge-limited-current in Lu2O3. The barrier height extracted from Schottky emission model is 0.96 eV in Sm2O3 thin film, while the activation energy of traps calculated from the Arrhenius plots is about 0.23 eV in Lu2O3 thin film. Additionally, the Ni/Sm2O3/ITO flexible memory device shows promising RS behavior with very low power of operation (˜30 μW) and small distribution of switching parameters. The memory reliability characteristics of switching endurance, data retention, good flexibility, and mechanical endurance show promising for future memory applications. The filament conduction model is adopted to describe the RS behavior in the Sm2O3 and Lu2O3 ReRAM devices. The improved RS performance in Sm2O3 thin film is attributed to the different physical properties of the thin films.

  9. Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from 177Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts

    PubMed Central

    Yong, Kwon Joong; Milenic, Diane E.; Baidoo, Kwamena E.; Brechbiel, Martin W.

    2016-01-01

    Radiolabeled antibodies (mAbs) provide efficient tools for cancer therapy. The combination of low energy β−-emissions (500 keVmax; 130 keVave) along with a γ-emission for imaging makes 177Lu (T1/2 = 6.7 day) a suitable radionuclide for radioimmunotherapy (RIT) of tumor burdens possibly too large to treat with α-particle radiation. RIT with 177Lu-trastuzumab has proven to be effective for treatment of disseminated HER2 positive peritoneal disease in a pre-clinical model. To elucidate mechanisms originating from this RIT therapy at the molecular level, tumor bearing mice (LS-174T intraperitoneal xenografts) were treated with 177Lu-trastuzumab comparatively to animals treated with a non-specific control, 177Lu-HuIgG, and then to prior published results obtained using 212Pb-trastuzumab, an α-particle RIT agent. 177Lu-trastuzumab induced cell death via DNA double strand breaks (DSB), caspase-3 apoptosis, and interfered with DNA-PK expression, which is associated with the repair of DNA non-homologous end joining damage. This contrasts to prior results, wherein 212Pb-trastuzumab was found to down-regulate RAD51, which is involved with homologous recombination DNA damage repair. 177Lu-trastuzumab therapy was associated with significant chromosomal disruption and up-regulation of genes in the apoptotic process. These results suggest an inhibition of the repair mechanism specific to the type of radiation damage being inflicted by either high or low linear energy transfer radiation. Understanding the mechanisms of action of β−- and α-particle RIT comparatively through an in vivo tumor environment offers real information suitable to enhance combination therapy regimens involving α- and β−-particle RIT for the management of intraperitoneal disease. PMID:27196891

  10. Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from (177)Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts.

    PubMed

    Yong, Kwon Joong; Milenic, Diane E; Baidoo, Kwamena E; Brechbiel, Martin W

    2016-01-01

    Radiolabeled antibodies (mAbs) provide efficient tools for cancer therapy. The combination of low energy β(-)-emissions (500 keVmax; 130 keVave) along with a γ-emission for imaging makes (177)Lu (T1/2 = 6.7 day) a suitable radionuclide for radioimmunotherapy (RIT) of tumor burdens possibly too large to treat with α-particle radiation. RIT with (177)Lu-trastuzumab has proven to be effective for treatment of disseminated HER2 positive peritoneal disease in a pre-clinical model. To elucidate mechanisms originating from this RIT therapy at the molecular level, tumor bearing mice (LS-174T intraperitoneal xenografts) were treated with (177)Lu-trastuzumab comparatively to animals treated with a non-specific control, (177)Lu-HuIgG, and then to prior published results obtained using (212)Pb-trastuzumab, an α-particle RIT agent. (177)Lu-trastuzumab induced cell death via DNA double strand breaks (DSB), caspase-3 apoptosis, and interfered with DNA-PK expression, which is associated with the repair of DNA non-homologous end joining damage. This contrasts to prior results, wherein (212)Pb-trastuzumab was found to down-regulate RAD51, which is involved with homologous recombination DNA damage repair. (177)Lu-trastuzumab therapy was associated with significant chromosomal disruption and up-regulation of genes in the apoptotic process. These results suggest an inhibition of the repair mechanism specific to the type of radiation damage being inflicted by either high or low linear energy transfer radiation. Understanding the mechanisms of action of β(-)- and α-particle RIT comparatively through an in vivo tumor environment offers real information suitable to enhance combination therapy regimens involving α- and β(-)-particle RIT for the management of intraperitoneal disease. PMID:27196891

  11. In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia.

    PubMed

    Redrobe, John P; Jørgensen, Morten; Christoffersen, Claus T; Montezinho, Liliana P; Bastlund, Jesper F; Carnerup, Martin; Bundgaard, Christoffer; Lerdrup, Linda; Plath, Niels

    2014-08-01

    Here, we present the pharmacological characterisation of Lu AF64280, a novel, selective, brain penetrant phosphodiesterase (PDE) 2A inhibitor, in in vitro/in vivo assays indicative of PDE2A inhibition, and in vivo models/assays relevant to cognitive processing or antipsychotic-like activity. The in vitro selectivity of Lu AF64280 was determined against a panel of PDE enzymes and 3',5'-cyclic guanosine monophosphate (cGMP) levels in the hippocampus were determined using in vivo microdialysis. Lu AF64280 potently inhibited hPDE2A (Ki = 20 nM), 50-fold above moderate inhibition of both hPDE9A (Ki = 1,000 nM) and hPDE10A (Ki = 1,800 nM), and displayed a >250-fold selectivity over all other full-length human recombinant PDE family members (Ki above 5,000 nM). Lu AF64280 (20 mg/kg) significantly increased cGMP levels in the hippocampus (p < 0.01 versus vehicle-treated mice), attenuated sub-chronic phencyclidine-induced deficits in novel object exploration in rats (10 mg/kg, p < 0.001 versus vehicle-treated), blocked early postnatal phencyclidine-induced deficits in the intradimensional/extradimensional shift task in rats (1 and 10 mg/kg, p < 0.001 versus vehicle-treated) and attenuated spontaneous P20-N40 auditory gating deficits in DBA/2 mice (20 mg/kg, p < 0.05 versus vehicle-treated). In contrast, Lu AF64280 failed to attenuate phencyclidine-induced hyperactivity in mice, and was devoid of antipsychotic-like activity in the conditioned avoidance response paradigm in rats, at any dose tested. Lu AF64280 represents a novel tool compound for selective PDE2A inhibition that substantiates a critical role of this enzyme in cognitive processes under normal and pathological conditions.

  12. Characterisation of Lu AF33241: A novel, brain-penetrant, dual inhibitor of phosphodiesterase (PDE) 2A and PDE10A.

    PubMed

    Redrobe, John P; Rasmussen, Lars K; Christoffersen, Claus T; Bundgaard, Christoffer; Jørgensen, Morten

    2015-08-15

    Here, we present a preliminary pharmacological characterisation of Lu AF33241, a novel, brain penetrant phosphodiesterase inhibitor of (PDE) 2A and 10A tool compound, in in vitro/in vivo assays indicative of PDE2A and/or PDE10A inhibition, and in vivo models/assays relevant to cognitive processing and antipsychotic-like activity. An assay was also included to investigate potential effects on motor activity. The in vitro selectivity of Lu AF33241 was determined against a panel of PDE enzymes. Lu AF33241 potently inhibited both full-length recombinant hPDE2A (Ki=4.2nM) and hPDE10A (Ki=42nM). The compound moderately inhibited both hPDE1C (Ki=1200nM), hPDE7B (Ki=890nM), and hPDE11A (Ki=1800nM). Lu AF33241 displayed a Ki above 5000nM against all other tested members of the PDE family. Albeit within a narrow dose range, Lu AF33241 attenuated sub-chronic phencyclidine-induced deficits in novel object recognition (3 and 10mg/kg), displayed antipsychotic-like activity in the conditioned avoidance response paradigm (10mg/kg), and did not induce catalepsy within a dose-range of 2-6mg/kg. Further catalepsy studies are needed to investigate a predictive safety window. Lu AF33241 represents a novel PDE2A/PDE10A inhibitor tool compound that may serve to further the understanding of the roles played by these enzymes in various CNS disorders.

  13. Molten salt synthesis, characterization, and luminescence properties of GdNbO{sub 4}/LuTaO{sub 4}:Eu{sup 3+} phosphors

    SciTech Connect

    Lin, Jintai; Zhou, Zhan; Wang, Qianming

    2013-08-01

    Graphical abstract: Well crystallized GdNbO4:Eu3{sup +} and LuTaO{sub 4}:Eu3{sup +} in the presence of fluxes were formed under reduced temperature in contrast to conventional method and their photophysical properties were studied. - Highlights: • Molten salt method was used to assemble two phosphors. • Both GdNbO{sub 4}:Eu{sup 3+} and LuTaO{sub 4}:Eu{sup 3+} could be red emissive. • The two powders were well dispersed as nano-particles. - Abstract: GdNbO{sub 4}:Eu{sup 3+} and LuTaO{sub 4}:Eu{sup 3+} have been successfully prepared with different fluxes (NaCl, KCl, NaCl and KCl) by the molten salt method. X-ray diffraction (XRD) patterns illustrated that well crystallized GdNbO{sub 4}:Eu{sup 3+} and LuTaO{sub 4}:Eu{sup 3+} in the presence of fluxes were formed under reduced temperature (900 °C) in contrast to conventional method (GdNbO{sub 4}:Eu{sup 3+}: around 1200 °C; LuTaO{sub 4}:Eu{sup 3+}: around 1500 °C). Scanning electron microscope (SEM) images revealed that well dispersed particles were achieved (granular or rod-like structures). Meanwhile, the photo-luminescent studies demonstrated that both niobate and tantalate are efficient hosts to sensitize europium red emissions. The results indicated that GdNbO{sub 4}:Eu{sup 3+} using NaCl as the flux gave much enhanced red emission whereas LuTaO{sub 4}:Eu{sup 3+} synthesized with the assistance of mixed salts (NaCl–KCl) achieved the best luminescence.

  14. What a Difference a Carbon Makes: H4octapa vs H4C3octapa, Ligands for In-111 and Lu-177 Radiochemistry

    PubMed Central

    2015-01-01

    The acyclic ligands H4C3octapa and p-SCN-Bn-H4C3octapa were synthesized for the first time, using nosyl protection chemistry. These new ligands were compared to the previously studied ligands H4octapa and p-SCN-Bn-H4octapa to determine the extent to which the addition of a single carbon atom to the backbone of the ligand would affect metal coordination, complex stability, and, ultimately, utility for in vivo radiopharmaceutical applications. Although only a single carbon atom was added to H4C3octapa and the metal donor atoms and denticity were not changed, the solution chemistry and radiochemistry properties were drastically altered, highlighting the importance of careful ligand design and radiometal–ligand matching. It was found that [In(C3octapa)]− and [Lu(C3octapa)]− were substantially different from the analogous H4octapa complexes, exhibiting fluxional isomerization and a higher number of isomers, as observed by 1H NMR, VT-NMR, and 2D COSY/HSQC-NMR experiments. Past evaluation of the DFT structures of [In(octapa)]− and [Lu(octapa)]− revealed very symmetric complexes; in contrast, the [In(C3octapa)]− and [Lu(C3octapa)]− complexes were much less symmetric, suggesting lower symmetry and less rigidity than that of the analogous H4octapa complexes. Potentiometric titrations revealed the formation constants (log KML, pM) were ∼2 units lower for the In3+ and Lu3+ complexes of H4C3octapa when compared to that of the more favorable H4octapa ligand (∼2 orders of magnitude less thermodynamically stable). The bifunctional ligands p-SCN-Bn-H4C3octapa and p-SCN-Bn-H4octapa were conjugated to the antibody trastuzumab and radiolabeled with 111In and 177Lu. Over a 5 day stability challenge experiment in blood serum, 111In-octapa– and 111In-C3octapa–trastuzumab immunoconjugates were determined to be ∼91 and ∼24% stable, respectively, and 177Lu-octapa– and 177Lu-C3octapa–trastuzumab, ∼89% and ∼4% stable, respectively. This work suggests that 5

  15. Pressure-Induced Zircon-Type to Scheelite-Type Phase Transition in Orthophosphates YbPO4 and LuPO4

    SciTech Connect

    Zhang, F.; Maik, L; Ewing, R; Lian, J; Wang, Z; Hu, J; Boatner, L

    2008-01-01

    The tetragonal orthophosphates, YbPO4 and LuPO4, were studied by in situ X-ray diffraction (XRD) at pressures up to 52 and 43 GPa, respectively. A reversible phase transition from the zircon structure-type to the scheelite structure-type was found at not, vert, similar22 GPa for YbPO4 and 19 GPa for LuPO4. Coinciding with the transition from the zircon structure-type to the scheelite structure-type, there is a not, vert, similar 10% reduction in volume and a significant increase in the bulk modulus for both compounds.

  16. Characterization of ErAs:GaAs and LuAs:GaAs Superlattice Structures for Continuous-Wave Terahertz Wave Generation through Plasmonic Photomixing

    NASA Astrophysics Data System (ADS)

    Yang, Shang-Hua; Salas, Rodolfo; Krivoy, Erica M.; Nair, Hari P.; Bank, Seth R.; Jarrahi, Mona

    2016-07-01

    We investigate the impact of ErAs:GaAs and LuAs:GaAs superlattice structures with different LuAs/ErAs nanoparticle depositions and superlattice geometries on terahertz radiation properties of plasmonic photomixers operating at a 780-nm optical wavelength. Our analysis indicates the crucial impact of carrier drift velocity and carrier lifetime on the performance of plasmonic photomixers. While higher carrier drift velocities enable higher optical-to-terahertz conversion efficiencies by offering higher quantum efficiencies, shorter carrier lifetimes allow achieving higher optical-to-terahertz conversion efficiencies by mitigating the negative impact of destructive terahertz radiation from slow photocarriers and preventing the carrier screening effect.

  17. Properties of triaxial, strongly deformed bands in {sup 167}Ta and {sup 167}Lu and the top-on-top model

    SciTech Connect

    Sugawara-Tanabe, Kazuko; Tanabe, Kosai

    2010-11-15

    Based on the particle-rotor model with one particle coupled to a triaxially deformed rotor, the experimental excitation energy relative to a reference E*-aI(I+1) and the ratio between interband and intraband electromagnetic transitions are well reproduced for {sup 167}Ta with {gamma}=19 deg. The same parameter set for the angular-momentum-dependent rigid-body moments of inertia attains good agreement with experimental data for the positive-parity triaxial, strongly deformed (TSD) band levels in {sup 167}Lu. An attempt is made to investigate the negative-parity TSD band in {sup 167}Lu.

  18. Lu-Hf garnet geochronology of the Salmon River Suture Zone, West-Central Idaho

    NASA Astrophysics Data System (ADS)

    Wilford, D. E.; Vervoort, J. D.; Lewis, R.; Tikoff, B.

    2011-12-01

    The Salmon River Suture Zone (SRSZ) in west-central Idaho records the accretion of island arc terranes to North America. It is modified by the Western Idaho Shear Zone (WISZ), a high strain zone within the SRSZ, which defines the present-day boundary between old continental North America and the accreted oceanic assemblages. Timing of the onset of deformation on the WISZ is not well established, primarily due to a poorly constrained metamorphic history. Existing garnet geochronologic studies of units within the SRSZ, using the Sm-Nd isotope system, have provided a framework towards a progressive accretion of arc-derived rocks to North America [1,2]. In this study, we report on the application of the Lu-Hf isotope system to provide ages of garnet growth within the suture zone. This system has the advantage of being insensitive to light rare earth element (LREE)-rich inclusions in garnet, which can complicate Sm-Nd geochronology. Samples were taken from several locations from both along and perpendicular to the suture zone. We report results on two of these samples, within and east of the WISZ. First, a garnet bearing leucocratic layer in a gneissic meta-sedimentary screen near Cascade, Idaho, yields a garnet age of 98 ± 2.0 Ma (2SD). The screen occurs completely within the orthogneisses of the WISZ, and displays similar fabrics and kinematics. Second, a biotite quartzo-feldspathic garnet gneiss from Elk City, Idaho, yields an age 100 ± 2.9 Ma (2SD). This location is ~35 km east of the WISZ, on a sub-parallel deformation zone that was active at the same time. Both samples were single-stage garnet fractions consisting of inclusion-free to inclusion-bearing fragments and whole rock pairs. These ages provide two important implications for the Mesozoic evolution of the western edge of North America. First, transpressional deformation in the WISZ occurred simultaneously with deformation on parallel structures in central Idaho, indicating that a wide zone of deformation

  19. Effects of Lu-Do-Huang Extract (LDHE) on Apoptosis Induction in Human Hep3B Cells.

    PubMed

    Huang, Hui-Yu; Chen, Li-Han; Liu, Chen-Wei; Chien, Ting-Yi; Yu, Yu-Ping; Kao, Yu-Yu; Yang, Jo-Hsuan; Tsai, Ying-Chieh

    2015-06-30

    Lu-Do-Huang (Pracparatum mungo) is a fermented mung bean [corrected] (Vigna radiata) and has long been used as a traditional and functional food in Traditional Chinese Medicine, especially for treating a variety of liver disorders. The present study aimed to evaluate the apoptotic effects of Lu-Do-Huang ethanol extract (LDHE) on Hep3B cells, a human hepatoma cell line. A variety of cellular assays, flow cytometry and immunoblotting were used. Our results showed that LDHE significantly inhibited Hep3B cells growth. Additionally, the cell cycle assay showed that LDHE prevented Hep3B cell entry into S phase and led to an arrest of Hep3B cells in the G₀/G₁ phase. LDHE induced Hep3B cells to undergo apoptosis as determined through Hep3B cell morphology changes, increase of apoptotic bodies, apoptotic cells, DNA fragmentations and caspase activity. We further examined the protein expression of TRADD, FADD, and Bax to verify the possible apoptotic pathways. The results indicated that LDHE-induced apoptosis in Hep3B cells might be mediated [corrected] by an extrinsic signaling pathway leading to an induction of apoptosis in Hep3B cells. In conclusion, LDHE induced apoptosis and cell cycle arrest in Hep3B cells. Our data provide the evidences regarding the anti-hepatoma potential of LDHE in Hep3B cells.

  20. Robust Charge and Magnetic Orders under Electric Field and Current in the Multiferroic LuFe2O4

    SciTech Connect

    Wen, J.; Xu, G.; Gu, G..D.; Shapiro, S.M.

    2010-04-01

    We performed elastic neutron-scattering measurements on the charge and magnetically ordered multiferroic material LuFe{sub 2}O{sub 4}. An external electric field along the [001] direction with strength up to 20 kV/cm applied at low temperature (-100 K) does not affect either the charge or magnetic structure. At higher temperatures (-360 K), before the transition to three-dimensional charge-ordered state, the resistivity of the sample is low, and an electric current was applied instead. A reduction in the charge and magnetic peak intensities occurs when the sample is cooled under a constant electric current. However, after calibrating the real sample temperature using its own resistance-temperature curve, we show that the actual sample temperature is higher than the thermometer readings, and the 'intensity reduction' is entirely due to internal sample heating by the applied current. Our results suggest that the charge and magnetic orders in LuFe{sub 2}O{sub 4} are unaffected by the application of external electric field and current, and previously observed electric-field and current effects can be naturally explained by internal sample heating.

  1. Ce(3+) /Tb(3+) non-/single-/co-doped K-Lu-F materials: synthesis, optical properties, and energy transfer.

    PubMed

    Cao, Chunyan; Xie, An; Noh, Hyeon Mi; Jeong, Jung Hyun

    2016-08-01

    Using a hydrothermal method, Ce(3+) /Tb(3+) non-/single-/co-doped K-Lu-F materials have been synthesized. The X-ray diffraction (XRD) results suggest that the Ce(3+) and/or Tb(3+) doping had great effects on the crystalline phases of the final samples. The field emission scanning electron microscopy (FE-SEM) images indicated that the samples were in hexagonal disk or polyhedron morphologies in addition to some nanoparticles, which also indicated that the doping also had great effects on the sizes and the morphologies of the samples. The energy-dispersive spectroscopy (EDS) patterns illustrated the constituents of different samples. The enhanced emissions of Tb(3+) were observed in the Ce(3+) /Tb(3+) co-doped K-Lu-F materials. The energy transfer (ET) efficiency ηT were calculated based on the fluorescence yield. The ET mechanism from Ce(3+) to Tb(3+) was confirmed to be the dipole-quadrupole interaction inferred from the theoretical analysis and the experimental data. Copyright © 2015 John Wiley & Sons, Ltd.

  2. Manufacturing issues and optical properties of rare-earth (Y, Lu, Sc, Nd) aluminate garnets composite transparent ceramics

    NASA Astrophysics Data System (ADS)

    Bonnet, Loïck; Boulesteix, Rémy; Maître, Alexandre; Sallé, Christian; Couderc, Vincent; Brenier, Alain

    2015-12-01

    In this work, a comparative study of reactive sintering and optical properties of three laser composite transparent ceramics doped with neodymium: Nd:YAG/Nd:YS1AG, Nd:YAG/Nd:LuAG and Nd:YS1AG/Nd:LuAG has been achieved. Samples were manufactured thanks to pressureless co-sintering under vacuum of bilayer powder compacts. The reaction sequence from primary oxides to final garnet phases has been investigated. Similar dilatometric behavior was observed during reactive-sintering for each composition. Differential shrinkage can be thus accommodated to some extent. Second, this work has shown that the intermediate zone at composites interface is composed of single-phased garnet solid-solution with continuous evolution from one side to the other. The thickness of the interdiffusion zone was found to be limited to about 100 μm in all cases and appeared to be well described by classical diffusion laws of Fick and Whipple-Le Claire. The analyses of spectroscopic properties of transparent ceramics composites have finally shown that composite ceramics should be suitable to produce dual wavelength emission for terahertz generation.

  3. Thermal Line Shift and Broadening of Ho(3+) in Y3AI5O12 and Lu3AIO12

    NASA Technical Reports Server (NTRS)

    Snoke, Elizabeth R.; Armagan, Guzin; Grew, Gary W.; Barnes, Norman P.; Walsh, Brian M.

    1995-01-01

    The interaction between the active ion and the host lattice manifests itself in two distinct ways: the static interaction with the crystal field that causes the splitting of the free ion energy levels and the active interaction through the surrounding phonon system that produces temperature dependent characteristics in the optical spectrum of the ion (e.g. line broadening and line shift). The strength of the splitting depends heavily on the electronic configuration of the atom. The model give by McCumber and Sturge describes the thermal effects on line width and position above 77 K with Raman scattering of Debye model phonons. These processes predict a Lorentzian line shape. However, below 77 K the principal contributions are from crystal inhomogeneities that result in a Gaussian line shape. We have investigated the experimental Stark levels as well as the thermal effects on the line width and the position of trivalent holmium ions in both yttrium aluminum garnet, Y3Al5O12 (YAG) and lutetium aluminum garnet, Lu3Al5O12 (LuAG) crystals. We have compared the Stark levels of the (5)I(6) state, and the thermal line shift and broadening of an isolated transition (Z2 to X13) between the (5)I(8) and (5)I(6) stark levels in these crystals. This transition occurs in the near infrared region at approximately 1117 nm.

  4. PET/CT alignment calibration with a non-radioactive phantom and the intrinsic 176Lu radiation of PET detector

    NASA Astrophysics Data System (ADS)

    Wei, Qingyang; Ma, Tianyu; Wang, Shi; Liu, Yaqiang; Gu, Yu; Dai, Tiantian

    2016-11-01

    Positron emission tomography/computed tomography (PET/CT) is an important tool for clinical studies and pre-clinical researches which provides both functional and anatomical images. To achieve high quality co-registered PET/CT images, alignment calibration of PET and CT scanner is a critical procedure. The existing methods reported use positron source phantoms imaged both by PET and CT scanner and then derive the transformation matrix from the reconstructed images of the two modalities. In this paper, a novel PET/CT alignment calibration method with a non-radioactive phantom and the intrinsic 176Lu radiation of the PET detector was developed. Firstly, a multi-tungsten-alloy-sphere phantom without positron source was designed and imaged by CT and the PET scanner using intrinsic 176Lu radiation included in LYSO. Secondly, the centroids of the spheres were derived and matched by an automatic program. Lastly, the rotation matrix and the translation vector were calculated by least-square fitting of the centroid data. The proposed method was employed in an animal PET/CT system (InliView-3000) developed in our lab. Experimental results showed that the proposed method achieves high accuracy and is feasible to replace the conventional positron source based methods.

  5. Efficient laser operation of Nd3+:Lu2O3 at various wavelengths between 917 nm and 1463 nm

    NASA Astrophysics Data System (ADS)

    von Brunn, P.; Heuer, A. M.; Fornasiero, L.; Huber, G.; Kränkel, C.

    2016-08-01

    Even though the first Nd3+-doped sesquioxide lasers have been realized more than 50 years ago, up to now no reports on efficient laser operation of Nd3+:doped sesquioxides can be found. In this work, we review the favorable spectroscopic properties of the sesquioxide Nd3+:Lu2O3 in terms of ground state absorption, stimulated emission, and excited state absorption cross sections as well as the upper level lifetime. Making use of these properties, we achieved efficient laser performance on eight different laser transitions in the wavelength range between 917 nm and 1463 nm under Ti:sapphire laser pumping using state-of-the-art HEM-grown Nd3+:Lu2O3 crystals with good optical quality. At the strongest transition around 1076 nm we determined a slope efficiency of 69%, which represents the highest efficiency ever obtained for a Nd3+-doped sesquioxide. Furthermore, we could generate watt level output powers and high slope efficiencies for seven other transitions. Lasers at 917 nm, 1053 nm, 1108 nm and 1463 nm were realized for the first time and the latter represents one of the longest laser wavelengths obtained on the 4F3/2  →  4I13/2 transition in Nd3+-doped materials.

  6. Influence of rare earth elements (Y, Gd and Lu) on the luminescent properties of green phosphor ZnMoO4:Tb3+.

    PubMed

    Xu, Y; Yang, W; Li, X; Li, W; Ju, X

    2014-11-01

    (Zn,Lnx )MoO4 :Tb(3+) (Ln = Y(3+), Gd(3+) and Lu(3+) ) were prepared using the co-precipitation method. Phase impurity, morphology and composition were investigated by power X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The experimental results show that crystal structure is not destroyed after doping an appropriate amount of Y(3+), Gd(3+) and Lu(3+). EDS analysis reveals that Y, Gd and Lu have been successfully doped into ZnMoO4 . In addition, the morphology of the phosphors is notably improved, exhibiting homogeneous dispersion morphology and irregular shapes of particle size ~ 0.5-1 µm. The luminescent intensity of (Zn,Lnx )MoO4:Tb(3+) (Ln = Y(3+), Gd(3+) and Lu(3+)) phosphor is obviously higher than that of ZnMoO4 :Tb(3+) phosphor. The energy transfer process between trivalent rare earth ions indicates that the inert earth ions can act as an energy bridge from MoO4(2-) to Tb(3+).

  7. Hf-Zr anomalies in clinopyroxene from mantle xenoliths from France and Poland: implications for Lu-Hf dating of spinel peridotite lithospheric mantle

    NASA Astrophysics Data System (ADS)

    Downes, Hilary; de Vries, Caja; Wittig, Nadine

    2014-09-01

    Clinopyroxenes in some fresh anhydrous spinel peridotite mantle xenoliths from the northern Massif Central (France) and Lower Silesia (Poland), analysed for a range of incompatible trace elements by laser ablation inductively coupled plasma mass spectrometry, show unusually strong negative anomalies in Hf and Zr relative to adjacent elements Sm and Nd, on primitive mantle-normalised diagrams. Similar Zr-Hf anomalies have only rarely been reported from clinopyroxene in spinel peridotite mantle xenoliths worldwide, and most are not as strong as the examples reported here. Low Hf contents give rise to a wide range of Lu/Hf ratios, which over geological time would result in highly radiogenic ɛHf values, decoupling them from ɛNd ratios. The high 176Lu/177Hf could in theory produce an isochronous relationship with 176Hf/177Hf over time; an errorchron is shown by clinopyroxene from mantle xenoliths from the northern Massif Central. However, in a review of the literature, we show that most mantle spinel peridotites do not show such high Lu/Hf ratios in their constituent clinopyroxenes, because they lack the distinctive Zr-Hf anomaly, and this limits the usefulness of the application of the Lu-Hf system of dating to garnet-free mantle rocks. Nevertheless, some mantle xenoliths from Poland or the Czech Republic may be amenable to Hf-isotope dating in the future.

  8. Hf-Zr anomalies in clinopyroxene from mantle xenoliths from France and Poland: implications for Lu-Hf dating of spinel peridotite lithospheric mantle

    NASA Astrophysics Data System (ADS)

    Downes, Hilary; de Vries, Caja; Wittig, Nadine

    2015-01-01

    Clinopyroxenes in some fresh anhydrous spinel peridotite mantle xenoliths from the northern Massif Central (France) and Lower Silesia (Poland), analysed for a range of incompatible trace elements by laser ablation inductively coupled plasma mass spectrometry, show unusually strong negative anomalies in Hf and Zr relative to adjacent elements Sm and Nd, on primitive mantle-normalised diagrams. Similar Zr-Hf anomalies have only rarely been reported from clinopyroxene in spinel peridotite mantle xenoliths worldwide, and most are not as strong as the examples reported here. Low Hf contents give rise to a wide range of Lu/Hf ratios, which over geological time would result in highly radiogenic ɛHf values, decoupling them from ɛNd ratios. The high 176Lu/177Hf could in theory produce an isochronous relationship with 176Hf/177Hf over time; an errorchron is shown by clinopyroxene from mantle xenoliths from the northern Massif Central. However, in a review of the literature, we show that most mantle spinel peridotites do not show such high Lu/Hf ratios in their constituent clinopyroxenes, because they lack the distinctive Zr-Hf anomaly, and this limits the usefulness of the application of the Lu-Hf system of dating to garnet-free mantle rocks. Nevertheless, some mantle xenoliths from Poland or the Czech Republic may be amenable to Hf-isotope dating in the future.

  9. Structure and magnetic properties of Y{sub 1-x}Lu{sub x}FeO{sub 3} (0 {<=} x {<=} 1) ceramics

    SciTech Connect

    Yuan Xueping; Tang Yankun; Sun Yue; Xu Mingxiang

    2012-03-01

    Polycrystalline Lu-doped YFeO{sub 3} samples with perovskite structure were synthesized by solid-state reaction. Powder X-ray diffraction, scanning electron microscopy, and energy dispersive X-ray analysis manifest the high quality of the samples. Room temperature {sup 57}Fe Moessbauer spectra indicate that only the Fe{sup 3+} exists in the samples, which excludes the formation of multiple valence of Fe. The large effective magnetic moments of Fe{sup 3+} obtained from the temperature dependence of magnetization data can be explained in terms of the formation of ferromagnetic clusters. Field-dependent magnetization reveals that all the samples show weak ferromagnetic property due to the small canting of the Fe{sup 3+} moments. The field-induced spin-reorientation was detected on YFeO{sub 3} and was gradually suppressed by Lu{sup 3+} doping. Polarization hysteresis loops of Y{sub 1-x}Lu{sub x}FeO{sub 3} (0 {<=} x {<=} 1) were observed at room temperature. Our results suggest that the multiferroic properties may exist in the Y{sub 1-x}Lu{sub x}FeO{sub 3} (0 {<=} x {<=} 1) ceramics.

  10. Organ doses from hepatic radioembolization with 90Y, 153Sm, 166Ho and 177Lu: A Monte Carlo simulation study using Geant4

    NASA Astrophysics Data System (ADS)

    Hashikin, N. A. A.; Yeong, C. H.; Guatelli, S.; Abdullah, B. J. J.; Ng, K. H.; Malaroda, A.; Rosenfeld, A. B.; Perkins, A. C.

    2016-03-01

    90Y-radioembolization is a palliative treatment for liver cancer. 90Y decays via beta emission, making imaging difficult due to absence of gamma radiation. Since post-procedure imaging is crucial, several theranostic radionuclides have been explored as alternatives. However, exposures to gamma radiation throughout the treatment caused concern for the organs near the liver. Geant4 Monte Carlo simulation using MIRD Pamphlet 5 reference phantom was carried out. A spherical tumour with 4.3cm radius was modelled within the liver. 1.82GBq of 90Y sources were isotropically distributed within the tumour, with no extrahepatic shunting. The simulation was repeated with 153Sm, 166Ho and 177Lu. The estimated tumour doses for all radionuclides were 262.9Gy. Tumour dose equivalent to 1.82GBq 90Y can be achieved with 8.32, 5.83, and 4.44GBq for 153Sm, 166Ho and 177Lu, respectively. Normal liver doses by the other radionuclides were lower than 90Y, hence beneficial for normal tissue sparing. The organ doses from 153Sm and 177Lu were relatively higher due to higher gamma energy, but were still well below 1Gy. 166Ho, 177Lu and 153Sm offer useful gamma emission for post-procedure imaging. They show potential as 90Y substitutes, delivering comparable tumour doses, lower normal liver doses and other organs doses far below the tolerance limit.

  11. Proton and Gamma Radiation Effects in Undoped, Single-doped and co-doped YLiF4 and LuLiF4

    NASA Technical Reports Server (NTRS)

    Lee, Hyung; Bai, Yingxin; Yu, Kirong; Singh, U.

    2009-01-01

    Proton and gamma radiation effects in various YLiF4 and LuLiF4 crystals have been investigated. The radiation induced color centers compared with six different kinds of crystal samples in ranges up to 200 krads and 200 MeV. The radiation induced absorption coefficients are strongly dependent on polarization and concentration of rare-earth ions.

  12. Structural analysis and crystal-field calculations of Nd3+ in GdxLu1-xTaO4 (x = 0.85) polycrystalline

    NASA Astrophysics Data System (ADS)

    Gao, Jin-Yun; Zhang, Qing-Li; Yang, Hua-Jun; Zhou, Peng-Yu; Sun, Dun-Lu; Yin, Shao-Tang; He, Ye

    2012-10-01

    The crystal structural parameters of Nd3+-doped rare earth orthotantalate GdxLu1-xTaO4 (x = 0.85) are determined by applying the Rietveld refinement to its X-ray diffraction, and its emission and excitation spectra at 77 K are analysed. The relativistic model of ab initio self-consistent DV-Xα method, which is applied to the cluster NdO8 in GdxLu1-xTaO4, and the effective Hamiltonian model are used to investigate its spin—orbit and crystal-field parameters. The free-ions and crystal-field parameters are fitted to the experimental energy levels at 77 K with a root-mean-square deviation of 14.92 cm-1. According to the crystal-field calculations, 96 levels of Nd3+ are assigned. Finally, the fitting results of free-ions and crystal-field parameters are compared with those already reported for Nd3+:YAlO3. The results indicate that the free-ion parameters are similar to those of the Nd3+ in GdxLu1-xTaO4 and YAlO3 hosts, and the crystal-field interaction of Nd3+ in GdxLu1-xTaO4 is stronger than that in YAlO3.

  13. Estimation of absorbed dose to the kidneys in patients after treatment with 177Lu-octreotate: comparison between methods based on planar scintigraphy

    PubMed Central

    2012-01-01

    Background Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used to treat neuroendocrine tumors with high somatostatin-receptor expression. 177Lu-octreotate is mainly excreted via the kidneys, but to some extent, accumulates in the kidney cortex due to, e.g., tubular reabsorption. Renal toxicity is one of the main limiting factors in 177Lu-octreotate treatment. Further knowledge of the biodistribution and dosimetry of 177Lu-octreotate in individual patients is needed. The aim of this study was to estimate the absorbed dose to the kidneys and compare the results obtained with planar imaging and different dosimetric methods: (1) conjugate-view (CV) method using patient-specific kidney sizes, (2) PA method, based on posterior images only, (3) CV method with reduced number of time points (CVreduced data), and (4) CV method using standard kidney sizes (CVstandard size). Methods Totally, 33 patients each received 3.4 to 8.2 GBq of 177Lu-octreotate up to five times, with infusion of lysine and arginine to block the renal uptake. Whole-body planar gamma camera images were acquired on days 0, 1, 2, and 7. The 177Lu concentration in the kidneys was determined by the CV method, and the absorbed dose was estimated with patient-specific organ sizes. Comparison to the CV method was made using posterior images only, together with the influence of the number of time points and with standard organ sizes. Results Large interindividual variations were found in the time-activity curve pattern and in the absorbed dose to the kidneys using the CV method: 0.33 to 2.4 Gy/GBq (mean =  0.80 Gy/GBq, SD = 0.30). In the individual patient, the mean deviation of all subsequent kidney doses compared to that of the first administration was 1% (SD = 19%) and 5% (SD = 23%) for the right and left kidneys, respectively. Excluding data for day 7 resulted in large variations in the absorbed dose. Conclusion Large interindividual variations in kidney dose were found, demonstrating the

  14. Oxygen miscibility gap and spin glass formation in the pyrochlore Lu{sub 2}Mo{sub 2}O{sub 7}

    SciTech Connect

    Clark, L.; Ritter, C.; Harrison, A.; Attfield, J.P.

    2013-07-15

    Rare earth (R) molybdate pyrochlores, R{sub 2}Mo{sub 2}O{sub 7}, are of interest as frustrated magnets. Polycrystalline samples of Lu{sub 2}Mo{sub 2}O{sub 7−x} prepared at 1600 °C display a coexistence of cubic pyrochlore phases. Rietveld fits to powder neutron diffraction data and chemical analyses show that the miscibility gap is between a stoichiometric x=0 and an oxygen-deficient x≈0.4 phase. Lu{sub 2}Mo{sub 2}O{sub 7} behaves as a spin glass material, with a divergence of field cooled and zero field cooled DC magnetic susceptibilities at a spin freezing temperature T{sub f}=16 K, that varies with frequency in AC measurements following a Vogel–Fulcher law. Lu{sub 2}Mo{sub 2}O{sub 6.6} is more highly frustrated spin glass and has T{sub f}=20 K. - Graphical abstract: The cubic Lu{sub 2}Mo{sub 2}O{sub 7−x} system exhibits a miscibility gap between coexisting pyrochlore phases at 1600 °C. Neutron powder diffraction refinement and chemical analysis shows that the gap separates stoichiometric x=0 and oxygen-deficient x≈0.4 phases. Lu{sub 2}Mo{sub 2}O{sub 7−x} has a frustrated spin glass ground state that is sensitive to the oxygen content. - Highlights: • The cubic Lu{sub 2}Mo{sub 2}O{sub 7−x} system has a miscibility gap between coexisting pyrochlore phases at 1600 °C. • Neutron powder diffraction shows that the gap separates x=0 and oxygen-deficient x≈0.4 phases. • Lu{sub 2}Mo{sub 2}O{sub 7−x} has a frustrated spin glass ground state that is sensitive to the oxygen content.

  15. Canonical polyadic decomposition of third-order semi-nonnegative semi-symmetric tensors using LU and QR matrix factorizations

    NASA Astrophysics Data System (ADS)

    Wang, Lu; Albera, Laurent; Kachenoura, Amar; Shu, Huazhong; Senhadji, Lotfi

    2014-12-01

    Semi-symmetric three-way arrays are essential tools in blind source separation (BSS) particularly in independent component analysis (ICA). These arrays can be built by resorting to higher order statistics of the data. The canonical polyadic (CP) decomposition of such semi-symmetric three-way arrays allows us to identify the so-called mixing matrix, which contains the information about the intensities of some latent source signals present in the observation channels. In addition, in many applications, such as the magnetic resonance spectroscopy (MRS), the columns of the mixing matrix are viewed as relative concentrations of the spectra of the chemical components. Therefore, the two loading matrices of the three-way array, which are equal to the mixing matrix, are nonnegative. Most existing CP algorithms handle the symmetry and the nonnegativity separately. Up to now, very few of them consider both the semi-nonnegativity and the semi-symmetry structure of the three-way array. Nevertheless, like all the methods based on line search, trust region strategies, and alternating optimization, they appear to be dependent on initialization, requiring in practice a multi-initialization procedure. In order to overcome this drawback, we propose two new methods, called [InlineEquation not available: see fulltext.] and [InlineEquation not available: see fulltext.], to solve the problem of CP decomposition of semi-nonnegative semi-symmetric three-way arrays. Firstly, we rewrite the constrained optimization problem as an unconstrained one. In fact, the nonnegativity constraint of the two symmetric modes is ensured by means of a square change of variable. Secondly, a Jacobi-like optimization procedure is adopted because of its good convergence property. More precisely, the two new methods use LU and QR matrix factorizations, respectively, which consist in formulating high-dimensional optimization problems into several sequential polynomial and rational subproblems. By using both LU

  16. [Preparation and Performances of the M'-Type LuTaO4:Eu³⁺ Transparent Scintillator Films].

    PubMed

    QIU, Zhi-che; GU, Mu; LIU, Xiao-lin; Liu, Bo; Huang, Shi-ming; Ni, Chen

    2016-02-01

    X-ray imaging has a very important role in life sciences and material microstructure analysis and other applications. One of the core components of X-ray imaging equipment is the X-rays-visible light conversion screen. Flashing transparent film is an effective way to achieve high spatial resolution X-ray imaging. M'-type LuTaO₄: Eu³+ is an excellent scintillation material. It has high light yield, high density, good radiation hardness and good chemical stability. Therefore, to research and develop the transparent conversion screen with M'-type LuTaO⁴: Eu+ is very important for the application of X-ray detector in high spatial resolution X-ray imaging. In this paper, the M'-type LuTaO₄:Eu³+ transparent scintillator films were successfully prepared from the inorganic salt and 2-methoxyethanol solution containing polyvinylpyrrolidone (PVP) via sol-gel technique, and transmittance, photoluminescence, X-ray excitation emission spectral and spatial resolution, and a series of film properties were characterized. A film thickness of about 2.1 µm was achieved after 8 coatings. The thick film was homogeneous and crack free, and the transmittance was approximately 70% in its emission region. The spatial resolution of the thick film was 1.5 µm, which measured by the standard spatial resolution panels. An X-ray imageof fruit fly was obtained by using this thick film. Additionally, thesol-gel derived M'-type LuTaO₄:Eu³+ thick film revealed excellent photoluminescence and X-ray excited luminescence per- formances. All results indicated that the M'-type LuTaO⁴:Eu³+ thick films have satisfied the essential requirements for applications in high-spatial-resolution X-ray imaging. PMID:27209726

  17. Dosimetry of [177Lu]-DO3A-VS-Cys40-Exendin-4 – impact on the feasibility of insulinoma internal radiotherapy

    PubMed Central

    Velikyan, Irina; Bulenga, Thomas N; Selvaraju, Ramkumar; Lubberink, Mark; Espes, Daniel; Rosenström, Ulrika; Eriksson, Olof

    2015-01-01

    [68Ga]-DO3A-VS-Cys40-Exendin-4 has been shown to be a promising imaging candidate for targeting glucagon like peptide-1 receptor (GLP-1R). In the light of radiotheranostics and personalized medicine the 177Lu-labelled analogue is of paramount interest. In this study we have investigated the organ distribution of [177Lu]-DO3A-VS-Cys40-Exendin-4 in rat and calculated human dosimetry parameters in order to estimate the maximal acceptable administered radioactivity, and thus potential applicability of [177Lu]-DO3A-VS-Cys40-Exendin-4 for internal radiotherapy of insulinomas. Nine male and nine female Lewis rats were injected with [177Lu]-DO3A-VS-Cys40-Exendin-4 for ex vivo organ distribution study at nine time points. The estimation of human organ/total body absorbed and total effective doses was performed using Organ Level Internal Dose Assessment Code software (OLINDA/EXM 1.1). Six more rats (male: n = 3; female: n = 3) were scanned by single photon emission tomography and computed tomography (SPECT-CT). The renal function and potential cell dysfunction were monitored by creatinine ISTAT and glucose levels. The fine uptake structure of kidney and pancreas was investigated by ex vivo autoradiography. Blood clearance and washout from most of the organs was fast. The kidney was the dose-limiting organ with absorbed dose of 5.88 and 6.04 mGy/MBq, respectively for female and male. Pancreatic beta cells demonstrated radioactivity accumulation. Renal function and beta cell function remained unaffected by radiation. The absorbed dose of [177Lu]-DO3A-VS-Cys40-Exendin-4 to kidneys may limit the clinical application of the agent. However, hypothetically, kidney protection and peptidase inhibition may allow reduction of kidney absorbed dose and amplification of tumour absorbed doses. PMID:25973333

  18. Anti-CD45 Radioimmunotherapy with 90Y but Not 177Lu Is Effective Treatment in a Syngeneic Murine Leukemia Model

    PubMed Central

    Orozco, Johnnie J.; Balkin, Ethan R.; Gooley, Ted A.; Kenoyer, Aimee; Hamlin, Donald K.; Wilbur, D. Scott; Fisher, Darrell R.; Hylarides, Mark D.; Shadman, Mazyar; Green, Damian J.; Gopal, Ajay K.; Press, Oliver W.; Pagel, John M.

    2014-01-01

    Radioimmunotherapy (RIT) for treatment of hematologic malignancies has primarily employed monoclonal antibodies (Ab) labeled with 131I or 90Y which have limitations, and alternative radionuclides are needed to facilitate wider adoption of RIT. We therefore compared the relative therapeutic efficacy and toxicity of anti-CD45 RIT employing 90Y and 177Lu in a syngeneic, disseminated murine myeloid leukemia (B6SJLF1/J) model. Biodistribution studies showed that both 90Y- and 177Lu-anti-murine CD45 Ab conjugates (DOTA-30F11) targeted hematologic tissues, as at 24 hours 48.8±21.2 and 156±14.6% injected dose per gram of tissue (% ID/g) of 90Y-DOTA-30F11 and 54.2±9.5 and 199±11.7% ID/g of 177Lu-DOTA-30F11 accumulated in bone marrow (BM) and spleen, respectively. However, 90Y-DOTA-30F11 RIT demonstrated a dose-dependent survival benefit: 60% of mice treated with 300 µCi 90Y-DOTA-30F11 lived over 180 days after therapy, and mice treated with 100 µCi 90Y-DOTA-30F11 had a median survival 66 days. 90Y-anti-CD45 RIT was associated with transient, mild myelotoxicity without hepatic or renal toxicity. Conversely, 177Lu- anti-CD45 RIT yielded no long-term survivors. Thus, 90Y was more effective than 177Lu for anti-CD45 RIT of AML in this murine leukemia model. PMID:25460570

  19. Effects of scandium substitution on the crystal structure and luminescence properties of LuBO{sub 3}: Ce{sup 3+}

    SciTech Connect

    Wu, Yuntao; Ren, Guohao; Ding, Dongzhou; Pan, Shangke; Yang, Fan

    2012-10-15

    The calcite phase of LuBO{sub 3} and ScBO{sub 3} polycrystalline powders were synthesized by solid state reaction method, and the Lu{sub 1-x}Sc{sub x}BO{sub 3}:Ce (x=0.2, 0.5, 0.7) single crystals were grown by the Czochralski method. A large composition deviation between the initial polycrystalline powders and final single crystal was confirmed by electron probe micro-analysis. Raman spectroscopy revealed that moderate lattice disorder was induced by scandium substitution. However, based on the single crystal X-ray study, we finally concluded that the crystal structure of lutetium scandium orthoborate still crystallized in the rhombohedral system belonging to R3{sup -}c. Furthermore, the relationship between the energies of the five 5d levels of Ce{sup 3+} and the crystalline environment was revealed. The total redshift, total crystal field splitting, and centroid shift of Lu{sub 1-x}Sc{sub x}BO{sub 3}:Ce{sup 3+} were calculated based on their VUV excitation spectra. The variations trend of these observed spectroscopic parameters was in accordance with the predicted ones. - Graphical abstract: The crystal structure of Lu{sub 1-x}Sc{sub x}BO{sub 3}:Ce is rhombohedral system with R3{sup -}c space group. The relationship between the energies of the five Ce{sup 3+} 5d levels and the crystalline environment is established. Highlights: Black-Right-Pointing-Pointer Moderate lattice disorder is induced by scandium doping. Black-Right-Pointing-Pointer The crystal structure of Lu{sub 1-x}Sc{sub x}BO{sub 3}:Ce is rhombohedral system with R3{sup -}c space group. Black-Right-Pointing-Pointer Relationship between energies of Ce{sup 3+} 5d levels and crystalline environment is established. Black-Right-Pointing-Pointer The spectroscopic parameters are experimentally and theoretically calculated.

  20. Study of structural, electronic and elastic properties of RPd{sub 3} (R = Lu and Sc) compounds

    SciTech Connect

    Thakur, Veena Pagare, Gitanjali Chouhan, S. S.; Sanyal, S. P.

    2014-04-24

    The structural, electronic and elastic properties of nonmagnetic RPd{sub 3} (R = Lu and Sc) compounds, which crystallize in AuCu{sub 3}-type structure, are studied using first principles density functional theory based on full potential linearized augmented plane wave (FP-LAPW) method. The calculations are carried out within the PBE-GGA and WC-GGA for the exchange correlation potential. Our calculated ground state properties such as lattice constant (a0), bulk modulus (B) and its pressure derivative (B’) are in good agreement with the experimental results. We first time predict the elastic constants for these compounds using different approximations of GGA. These RPd{sup 3} compounds are found to be ductile in nature in accordance with Pugh’s criteria. The computed electronic band structures and density of states show metallic character of these compounds.

  1. Formation of Po isotopes in the reactions {sup 27}Al + {sup 175}Lu and {sup 31}P + {sup 169}Tm

    SciTech Connect

    Andreev, A.N.; Bogdanov, D.D.; Eremin, A.V.

    1995-05-01

    The excitation functions and the cross sections for the formation of {sup 192-198}Po isotopes in the reactions {sup 27}Al + {sup 175}Lu and {sup 31}P + {sup 169}Tm are measured. A comparison of the results obtained for these reactions with the data on the cross sections for the formation of Po isotopes in the reaction {sup 100}Mo + {sup 92-100}Mo leads to the conclusion that the characteristics of the evaporation channel do not depend on the mass of the bombarding ion up to the complete symmetry in the input channel. It is shown that the experimental data can be adequately described using the statistical approach to the deexcitation of a compound nucleus only under the assumption that the liquid-drop fission barrier is reduced significantly for neutron-deficient Po isotopes. 21 refs., 5 figs., 2 tabs.

  2. 1.31 and 1.32 μm dual-wavelength Nd:LuLiF4 laser

    NASA Astrophysics Data System (ADS)

    Li, Shixia; Li, Tao; Zhao, Shengzhi; Li, Guiqiu; Hang, Yin; Zhang, Peixiong

    2016-07-01

    We demonstrate the operation of Nd:LuLiF4 laser with efficient 1.31 and 1.32 μm dual-wavelength. Maximum continuous-wave output power of 1.63 W is obtained at an incident pump power of 9.97 W and 8% transmission of output coupler (OC), giving a slope efficiency of 17.9%. When monolayer graphene is employed as saturable absorber, stable passively Q-switched 1.31 and 1.32 μm dual-wavelength laser operation still remains. The maximum average output power of 1.33 W, the largest pulse energy of 17.3 μJ and the highest peak power of 111.6 W are achieved with the 8% OC. Meanwhile, the shortest pulse duration of 133 ns and the highest repetition rate of 91 kHz are rendered by the 3.8% OC cavity.

  3. Spontaneous decays of magneto-elastic excitations in non-collinear antiferromagnet (Y,Lu)MnO3

    PubMed Central

    Oh, Joosung; Le, Manh Duc; Nahm, Ho-Hyun; Sim, Hasung; Jeong, Jaehong; Perring, T. G.; Woo, Hyungje; Nakajima, Kenji; Ohira-Kawamura, Seiko; Yamani, Zahra; Yoshida, Y.; Eisaki, H.; Cheong, S. -W.; Chernyshev, A. L.; Park, Je-Geun

    2016-01-01

    Magnons and phonons are fundamental quasiparticles in a solid and can be coupled together to form a hybrid quasi-particle. However, detailed experimental studies on the underlying Hamiltonian of this particle are rare for actual materials. Moreover, the anharmonicity of such magnetoelastic excitations remains largely unexplored, although it is essential for a proper understanding of their diverse thermodynamic behaviour and intrinsic zero-temperature decay. Here we show that in non-collinear antiferromagnets, a strong magnon–phonon coupling can significantly enhance the anharmonicity, resulting in the creation of magnetoelastic excitations and their spontaneous decay. By measuring the spin waves over the full Brillouin zone and carrying out anharmonic spin wave calculations using a Hamiltonian with an explicit magnon–phonon coupling, we have identified a hybrid magnetoelastic mode in (Y,Lu)MnO3 and quantified its decay rate and the exchange-striction coupling term required to produce it. PMID:27759004

  4. Observation of a topologically non-trivial surface state in half-Heusler PtLuSb (001) thin films

    NASA Astrophysics Data System (ADS)

    Logan, J. A.; Patel, S. J.; Harrington, S. D.; Polley, C. M.; Schultz, B. D.; Balasubramanian, T.; Janotti, A.; Mikkelsen, A.; Palmstrøm, C. J.

    2016-06-01

    The discovery of topological insulators, materials with bulk band gaps and protected cross-gap surface states in compounds such as Bi2Se3, has generated much interest in identifying topological surface states (TSSs) in other classes of materials. In particular, recent theoretical calculations suggest that TSSs may be found in half-Heusler ternary compounds. If experimentally realizable, this would provide a materials platform for entirely new heterostructure spintronic devices that make use of the structurally identical but electronically varied nature of Heusler compounds. Here we show the presence of a TSS in epitaxially grown thin films of the half-Heusler compound PtLuSb. Spin- and angle-resolved photoemission spectroscopy, complemented by theoretical calculations, reveals a surface state with linear dispersion and a helical tangential spin texture consistent with previous predictions. This experimental verification of topological behaviour is a significant step forward in establishing half-Heusler compounds as a viable material system for future spintronic devices.

  5. Observation of a topologically non-trivial surface state in half-Heusler PtLuSb (001) thin films.

    PubMed

    Logan, J A; Patel, S J; Harrington, S D; Polley, C M; Schultz, B D; Balasubramanian, T; Janotti, A; Mikkelsen, A; Palmstrøm, C J

    2016-01-01

    The discovery of topological insulators, materials with bulk band gaps and protected cross-gap surface states in compounds such as Bi2Se3, has generated much interest in identifying topological surface states (TSSs) in other classes of materials. In particular, recent theoretical calculations suggest that TSSs may be found in half-Heusler ternary compounds. If experimentally realizable, this would provide a materials platform for entirely new heterostructure spintronic devices that make use of the structurally identical but electronically varied nature of Heusler compounds. Here we show the presence of a TSS in epitaxially grown thin films of the half-Heusler compound PtLuSb. Spin- and angle-resolved photoemission spectroscopy, complemented by theoretical calculations, reveals a surface state with linear dispersion and a helical tangential spin texture consistent with previous predictions. This experimental verification of topological behaviour is a significant step forward in establishing half-Heusler compounds as a viable material system for future spintronic devices.

  6. Comment on "Propionaldehyde infrared cross-sections and band strengths" by B. Köroğlu et al. [1

    NASA Astrophysics Data System (ADS)

    Richter, Wagner Eduardo; Bruns, Roy Edward

    2016-08-01

    The propionaldehyde infrared regional integrated area reported by Köroğlu et al. were re-examined. Even though the spectrum seems to be recorded correctly, the comparison between their values with the data obtained by the integration of the propionaldehyde spectrum available in the PNNL database suggests that a scaling factor of 2.3025 (the ratio between ln and log bases) is the reason for their results being lower than those expected based on other literature values and quantum chemical estimates. Revised values were then reported for the four spectral regions evaluated by these authors, resulting in a much better agreement between both theoretical and experimental results for not only for this molecule but also for others like acetone and acetaldehyde.

  7. Study of 57 Fe Mössbauer effect in RFe2Zn20 ( R = Lu, Yb, Gd)

    DOE PAGES

    Bud’ko, Sergey L.; Kong, Tai; Ma, Xiaoming; Canfield, Paul C.

    2015-08-04

    In this document we report measurements of 57Fe Mössbauer spectra for RFe2Zn20 (R = Lu, Yb, Gd) from ~ 4.5 K to room temperature. The obtained isomer shift values are very similar for all three compounds, their temperature dependence was analyzed within the Debye model and resulted in an estimate of the Debye temperatures of 450-500 K. The values of quadrupole splitting at room temperature change with the cubic lattice constant a in a linear fashion. For GdFe2Zn20, ferromagnetic order is seen as an appearance of a sextet in the spectra. The 57Fe site hyperfine field for T → 0more » was evaluated to be ~ 2.4 T.« less

  8. Time-resolved x-ray diffraction study of photoinduced strains in h -LuFeO3 thin film

    NASA Astrophysics Data System (ADS)

    Sinha, Kishan; Jiang, Xuanyuan; Wang, Xiao; Dichiara, Anthony; Cheng, Xuemei; Li, Yuelin; Xu, Xiaoshan

    2015-03-01

    We have studied the structural response of epitaxially stabilized h-LuFeO3 (0001) thin film to above-band-gap optical excitation (pump) using time-resolved x-ray diffraction (probe) at picosecond time scale. The shift in (004) Bragg peak induced by a 390 nm excitation (30 ps duration) has been studied as a function of pump fluence and pump-probe time delay. The out-of-plane photoinduced lattice strain (Δc / c) exhibits a non-linear relation with fluence. The relaxation time is on the order of 1 ns. These observations suggest a relaxation mechanism that may be mediated by combined effects of charge recombination and phonon relaxation. This work at is supported by Nebraska EPESCoR (UNL), by NSF CAREER award (No. 1053854) (Bryn Mawr College), and by US-DOE, Office of Science, BES (No. DE-AC02-06CH11357) (ANL).

  9. Yb:Lu2SiO5 crystal : characterization of the laser emission along the three dielectric axes

    NASA Astrophysics Data System (ADS)

    Toci, Guido; Pirri, Angela; Beitlerova, Alena; Shoji, Yasuhiro; Yoshikawa, Akira; Hybler, Jiri; Nikl, Martin; Vannini, Matteo

    2015-05-01

    Yb:doped Lu2SiO5 (Lutetium orthosilicate, LSO) is an optically biaxial crystal with laser emission in the range 1000- 1100 nm. It features different absorption and emission spectra for polarization along its three dielectric axes. In this work we have characterized the laser emission properties of Yb:LSO along all the three dielectric axis, evidencing differences that can be exploited in the design of ultrafast laser sources. The material was tested in a longitudinally pumped laser cavity. The laser emission efficiency was found similar along all the three dielectric axes, with slope efficiencies around 90% in most cases. Regarding the tuning range, for the most favourable polarization direction we obtained a continuously tunable emission between 993 and 1088 nm (i. e. 95 nm) peaked at 1040 nm. The tuning curves along the three dielectric axes spanned similar ranges but with relevant differences in the shape.

  10. Observation of unusual topological surface states in half-Heusler compounds LnPtBi (Ln=Lu, Y)

    PubMed Central

    Liu, Z. K.; Yang, L. X.; Wu, S.-C.; Shekhar, C.; Jiang, J.; Yang, H. F.; Zhang, Y.; Mo, S.-K.; Hussain, Z.; Yan, B.; Felser, C.; Chen, Y. L.

    2016-01-01

    Topological quantum materials represent a new class of matter with both exotic physical phenomena and novel application potentials. Many Heusler compounds, which exhibit rich emergent properties such as unusual magnetism, superconductivity and heavy fermion behaviour, have been predicted to host non-trivial topological electronic structures. The coexistence of topological order and other unusual properties makes Heusler materials ideal platform to search for new topological quantum phases (such as quantum anomalous Hall insulator and topological superconductor). By carrying out angle-resolved photoemission spectroscopy and ab initio calculations on rare-earth half-Heusler compounds LnPtBi (Ln=Lu, Y), we directly observe the unusual topological surface states on these materials, establishing them as first members with non-trivial topological electronic structure in this class of materials. Moreover, as LnPtBi compounds are non-centrosymmetric superconductors, our discovery further highlights them as promising candidates of topological superconductors. PMID:27671444

  11. CW and passively Q-switched laser performance of Nd:Lu2SiO5 crystal

    NASA Astrophysics Data System (ADS)

    Xu, Xiaodong; Di, Juqing; Zhang, Jian; Tang, Dingyuan; Xu, Jun

    2016-01-01

    We demonstrated an efficient and controllable dual-wavelength continuous-wave (CW) laser of Nd:Lu2SiO5 (Nd:LSO) crystal. The maximum output power was 3.02 W at wavelength of 1075 nm and 1079 nm, and with increasing of absorbed pump power, the ratio of 1079 nm laser rose. The slope efficiency of 65.6% and optical-to-optical conversion efficiency of 63.3% were obtained. The passively Q-switched laser properties of Nd:LSO were investigated for the first time. The shortest pulse, maximum pulse energy and peak power were 11.58 ns, 29.05 μJ and 2.34 kW, respectively.

  12. Connections between high-K and low-K states in the s-process nucleus {sup 176}Lu

    SciTech Connect

    Dracoulis, G. D.; Lane, G. J.; Byrne, A. P.; Kondev, F. G.; Carpenter, M. P.; Janssens, R. V. F.; Lauritsen, T.; Lister, C. J.; Seweryniak, D.; Chowdhury, P.

    2010-01-15

    Gamma-ray branches that connect high-K states to low-K states in the s-process nucleus {sup 176}Lu were observed, thus providing a link between the 58 Gyr, 7{sup -} ground state and the 5.3 h, 1{sup -} isomeric state. High sensitivity and unambiguous placement were achieved through the study of the decay of the 58 {mu}s K{sup {pi}}=14{sup +} isomer using {gamma}-{gamma}-coincidence measurements. The large number of decay paths from the isomer provides a means of populating a broad selection of states from above, resulting, paradoxically, in higher sensitivity than in cases where low-spin input reactions are used. The out-of band decay widths important for excitation processes in stars are quantified.

  13. Optical spectroscopic study of multiferroic BiFeO3 and LuFe2O4

    NASA Astrophysics Data System (ADS)

    Xu, Xiaoshan

    2010-03-01

    Iron-based multiferroics such as BiFeO3 and LuFe2O4 exhibit the highest magnetic and ferroelectric ordering temperatures among known multiferroics. LuFe2O4 is a frustrated system with several phase transitions that result in electronically driven multiferroicity. To understand how this peculiar multiferroic mechanism correlates with magnetism, we studied electronic excitations by optical spectroscopy and other complementary techniques. We show that the charge order, which determines the dielectric properties, is due to the ``order by fluctuation'' mechanism, evidenced by the onset of charge fluctuation well below the charge ordering transition. We also find a low temperature monoclinic distortion driven by both temperature and magnetic field, indicating strong coupling between structure, magnetism and charge order. BiFeO3 is the only known single phase multiferroics with room temperature magnetism and ferroelectricity. To investigate the spin-charge coupling, we measured the optical properties of BiFeO3. We find that the absorption onset occurs due to on-site Fe^3+ excitations at 1.41 and 1.90 eV. Temperature and magnetic-field-induced spectral changes reveal complex interactions between on-site crystal-field and magnetic excitations in the form of magnon sidebands. The sensitivity of the magnon sidebands allows us to map out the magnetic-field temperature phase diagram which demonstrates optical evidence for spin spiral quenching above 20 T and suggests a spin domain reorientation near 10 T. Work done in collaboration with T.V. Brinzari, R.C. Rai, M. Angst, R.P. Hermann, A.D. Christianson, J.-W. Kim, Z. Islam, B.C. Sales, D. Mandrus, S. Lee, Y.H. Chu, L. W. Martin, A. Kumar, R. Ramesh, S.W. Cheong, S. McGill, and J.L. Musfeldt.

  14. Geodynamic investigation of the processes that control Lu-Hf isotopic differences between different mantle domains and the crust

    NASA Astrophysics Data System (ADS)

    Jones, Rosie; van Keken, Peter; Hauri, Erik; Vervoort, Jeff; Ballentine, Chris J.

    2016-04-01

    The chemical and isotopic composition of both the Earth's mantle and the continental crust are greatly influenced by subduction zone processes, such as the formation of continental crust through arc volcanism and the recycling of surface material into the deep mantle. Here we use a combined geodynamical-geochemical approach to investigate the long term role of subduction on the Lu-Hf isotopic evolution of the mantle and the continental crust. We apply the geodynamic model developed by Brandenburg et al., 2008. This model satisfies the geophysical constraints of oceanic heat flow and average plate velocities, as well as geochemical observations such as 40Ar in the atmosphere, and reproduces the geochemical distributions observed in multiple isotope systems which define the HIMU, MORB and EM1 mantle endmembers. We extend this application to investigate the detail of terrestrial Lu-Hf isotope distribution and evolution, and specifically to investigate the role of sediment recycling in the generation of EM2 mantle compositions. The model has been updated to produce higher resolution results and to include a self-consistent reorganisation of the plates with regions of up-/down-wellings. The model assumes that subduction is initiated at 4.5 Ga and that a transition from 'dry' to 'wet' subduction occurred at 2.5 Ga. The modelling suggests that the epsilon Hf evolution of the upper mantle can be generated through the extraction and recycling of the oceanic crust, and that the formation of continental crust plays a lesser role. Our future intention is to utilise the model presented here to investigate the differences observed in the noble gas compositions (e.g., 40Ar/36Ar, 3He/4He) of MORB and OIB. Brandenburg, J.P., Hauri, E.H., van Keken, P.E., Ballentine, C.J., 2008. Earth and Planetary Science Letters 276, 1-13.

  15. Adaptive robust motion trajectory tracking control of pneumatic cylinders with LuGre model-based friction compensation

    NASA Astrophysics Data System (ADS)

    Meng, Deyuan; Tao, Guoliang; Liu, Hao; Zhu, Xiaocong

    2014-07-01

    Friction compensation is particularly important for motion trajectory tracking control of pneumatic cylinders at low speed movement. However, most of the existing model-based friction compensation schemes use simple classical models, which are not enough to address applications with high-accuracy position requirements. Furthermore, the friction force in the cylinder is time-varying, and there exist rather severe unmodelled dynamics and unknown disturbances in the pneumatic system. To deal with these problems effectively, an adaptive robust controller with LuGre model-based dynamic friction compensation is constructed. The proposed controller employs on-line recursive least squares estimation (RLSE) to reduce the extent of parametric uncertainties, and utilizes the sliding mode control method to attenuate the effects of parameter estimation errors, unmodelled dynamics and disturbances. In addition, in order to realize LuGre model-based friction compensation, the modified dual-observer structure for estimating immeasurable friction internal state is developed. Therefore, a prescribed motion tracking transient performance and final tracking accuracy can be guaranteed. Since the system model uncertainties are unmatched, the recursive backstepping design technology is applied. In order to solve the conflicts between the sliding mode control design and the adaptive control design, the projection mapping is used to condition the RLSE algorithm so that the parameter estimates are kept within a known bounded convex set. Finally, the proposed controller is tested for tracking sinusoidal trajectories and smooth square trajectory under different loads and sudden disturbance. The testing results demonstrate that the achievable performance of the proposed controller is excellent and is much better than most other studies in literature. Especially when a 0.5 Hz sinusoidal trajectory is tracked, the maximum tracking error is 0.96 mm and the average tracking error is 0.45 mm. This

  16. Preparation and imaging performance of nanoparticulated LuPO4:Eu semitransparent films under x-ray radiation

    NASA Astrophysics Data System (ADS)

    Seferis, I. E.; Zeler, J.; Michail, C.; Valais, I.; Fountos, G.; Kalyvas, N.; Bakas, A.; Kandarakis, I.; Panayiotakis, G. S.; Zych, E.

    2015-12-01

    The aim of the present work was to demonstrate the fabrication technique for semitransparent layers of nanoparticulated (~50 nm) LuPO4:15%Eu phosphors. Furthermore, to present their basic luminescent properties and provide results regarding their performance in a planar imaging system incorporating a CMOS photodetector. Parameters such as the Detective Quantum Efficiency (DQE), the Normalized Noise Power Spectrum (NNPS) and the Modulation Transfer Function (MTF), were investigated. The NNPS was found to present significantly higher values near the zero frequency for the 67 μm, 100 μm films, pointing on their higher non uniformities compared to the 220 and 460 μm films For the two thickest films (460 μm and 220 μm) the MTF curves practically do not differ, while MTFs for the thinner layers of 100 μm and 67 μm are higher as the layer's thickness decreases. The higher DQE values observed for the 220 μm and 460 μm films up to medium frequencies, while at high frequencies the DQE values are comparable. Although the MTF values of these films are much lower than the thinner screens, the capability of the higher x-ray absorption, in conjunction with the low noise properties, lead to higher DQE values. The LuPO4:Eu semitransparent films seems to be a very promising scintillator for stationary x-ray imaging. The acquired data allow to predict that high-temperature sintering of our films under pressure may help to improve their imaging quality, since such a processing should increase the luminescence efficiency without significant growth of the grains, and thus without sacrificing their translucent character.

  17. Colonization of Morus alba L. by the plant-growth-promoting and antagonistic bacterium Burkholderia cepacia strain Lu10-1

    PubMed Central

    2010-01-01

    Background Anthracnose, caused by Colletotrichum dematium, is a serious threat to the production and quality of mulberry leaves in susceptible varieties. Control of the disease has been a major problem in mulberry cultivation. Some strains of Burkholderia cepacia were reported to be useful antagonists of plant pests and could increase the yields of several crop plants. Although B. cepacia Lu10-1 is an endophytic bacterium obtained from mulberry leaves, it has not been deployed to control C. dematium infection in mulberry nor its colonization patterns in mulberry have been studied using GFP reporter or other reporters. The present study sought to evaluate the antifungal and plant-growth-promoting properties of strain Lu10-1, to clarify its specific localization within a mulberry plant, and to better understand its potential as a biocontrol and growth-promoting agent. Results Lu10-1 inhibited conidial germination and mycelial growth of C. dematium in vitro; when applied on leaves or to the soil, Lu10-1 also inhibited the development of anthracnose in a greenhouse, but the effectiveness varied with the length of the interval between the strain treatment and inoculation with the pathogen. Strain Lu10-1 could survive in both sterile and non-sterile soils for more than 60 days. The strain produced auxins, contributed to P solubilization and nitrogenase activity, and significantly promoted the growth of mulberry seedlings. The bacteria infected mulberry seedlings through cracks formed at junctions of lateral roots with the main root and in the zone of differentiation and elongation, and the cells were able to multiply and spread, mainly to the intercellular spaces of different tissues. The growth in all the tissues was around 1-5 × 105 CFU per gram of fresh plant tissue. Conclusions Burkholderia cepacia strain Lu10-1 is an endophyte that can multiply and spread in mulberry seedlings rapidly and efficiently. The strain is antagonistic to C. dematium and acts as an

  18. 177Lu-DO3A-HSA-Z EGFR:1907: characterization as a potential radiopharmaceutical for radionuclide therapy of EGFR-expressing head and neck carcinomas.

    PubMed

    Hoppmann, Susan; Qi, Shibo; Miao, Zheng; Liu, Hongguang; Jiang, Han; Cutler, Cathy S; Bao, Ande; Cheng, Zhen

    2012-06-01

    Epidermal growth factor receptor 1 (EGFR) is an attractive target for radionuclide therapy of head and neck carcinomas. Affibody molecules against EGFR (Z(EGFR)) show excellent tumor localizations in imaging studies. However, one major drawback is that radiometal-labeled Affibody molecules display extremely high uptakes in the radiosensitive kidneys which may impact their use as radiotherapeutic agents. The purpose of this study is to further explore whether radiometal-labeled human serum albumin (HSA)-Z(EFGR) bioconjugates display desirable profiles for the use in radionuclide therapy of EGFR-positive head and neck carcinomas. The Z(EFGR) analog, Ac-Cys-Z(EGFR:1907), was site-specifically conjugated with HSA. The resulting bioconjugate 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A)-HSA-Z(EGFR:1907) was then radiolabeled with either (64)Cu or (177)Lu and subjected to in vitro cell uptake and internalization studies using the human oral squamous carcinoma cell line SAS. Positron emission tomography (PET), single photon emission computed tomography (SPECT), and biodistribution studies were conducted using SAS-tumor-bearing mice. Cell studies revealed a high (8.43 ± 0.55 % at 4 h) and specific (0.95 ± 0.09 % at 4 h) uptake of (177)Lu-DO3A-HSA-Z(EGFR:1907) as determined by blocking with nonradioactive Z(EGFR:1907). The internalization of (177)Lu-DO3A-HSA-Z(EGFR:1907) was verified in vitro and found to be significantly higher than that of (177)Lu-labeled Z(EFGR) at 2-24 h of incubation. PET and SPECT studies showed good tumor imaging contrasts. The biodistribution of (177)Lu-DO3A-HSA-Z(EGFR:1907) in SAS-tumor-bearing mice displayed high tumor uptake (5.1 ± 0.44 % ID/g) and liver uptake (31.5 ± 7.66 % ID/g) and moderate kidney uptake (8.5 ± 1.08 % ID/g) at 72 h after injection. (177)Lu-DO3A-HSA-Z(EGFR:1907) shows promising in vivo profiles and may be a potential radiopharmaceutical for radionuclide therapy of EGFR-expressing head and neck carcinomas

  19. Rapid and Energy-Saving Microwave-Assisted Solid-State Synthesis of Pr(3+)-, Eu(3+)-, or Tb(3+)-Doped Lu2O3 Persistent Luminescence Materials.

    PubMed

    Pedroso, Cássio C S; Carvalho, José M; Rodrigues, Lucas C V; Hölsä, Jorma; Brito, Hermi F

    2016-08-01

    Persistent luminescence materials Lu2O3:R(3+),M (Pr,Hf(IV); Eu; or Tb,Ca(2+)) were successfully and rapidly (22 min) prepared by microwave-assisted solid-state synthesis (MASS) using a carbon microwave susceptor and H3BO3 as flux. Reaction times are reduced by up to 93% over previous synthetic methods, without special gases application and using a domestic microwave oven. All materials prepared with H3BO3 flux exhibit LuBO3 impurities that were quantified by Rietveld refinement from synchrotron radiation X-ray powder diffraction patterns. The flux does not considerably affect the crystalline structure of the C-Lu2O3, however. Scanning electron micrographs suggest low surface area when H3BO3 flux is used in the materials' synthesis, decreasing the amount of surface hydroxyl groups in Lu2O3 and improving the luminescence intensity of the phosphors. The carbon used as the susceptor generates CO gas, leading to complete reduction of Tb(IV) to Tb(3+) and partial conversion of Pr(IV) to Pr(3+) present in the Tb4O7 and Pr6O11 precursors, as indicated by X-ray absorption near-edge structure data. Persistent luminescence spectra of the materials show the red/near-IR, reddish orange, and green emission colors assigned to the 4f(n) → 4f(n) transitions characteristics of Pr(3+), Eu(3+), and Tb(3+) ions, respectively. Differences between the UV-excited and persistent luminescence spectra can be explained by the preferential persistent luminescence emission of R(3+) ion in the S6 site rather than R(3+) in the C2 site. In addition, inclusion of Hf(IV) and Ca(2+) codopants in the Lu2O3 host increases the emission intensity and duration of persistent luminescence due to generation of traps caused by charge compensation in the lattice. Photonic materials prepared by MASS with H3BO3 flux show higher persistent luminescence performance than those prepared by the ceramic method or MASS without flux. Color tuning of persistent luminescence in Lu2O3:R(3+),M provides potential

  20. Rapid and Energy-Saving Microwave-Assisted Solid-State Synthesis of Pr(3+)-, Eu(3+)-, or Tb(3+)-Doped Lu2O3 Persistent Luminescence Materials.

    PubMed

    Pedroso, Cássio C S; Carvalho, José M; Rodrigues, Lucas C V; Hölsä, Jorma; Brito, Hermi F

    2016-08-01

    Persistent luminescence materials Lu2O3:R(3+),M (Pr,Hf(IV); Eu; or Tb,Ca(2+)) were successfully and rapidly (22 min) prepared by microwave-assisted solid-state synthesis (MASS) using a carbon microwave susceptor and H3BO3 as flux. Reaction times are reduced by up to 93% over previous synthetic methods, without special gases application and using a domestic microwave oven. All materials prepared with H3BO3 flux exhibit LuBO3 impurities that were quantified by Rietveld refinement from synchrotron radiation X-ray powder diffraction patterns. The flux does not considerably affect the crystalline structure of the C-Lu2O3, however. Scanning electron micrographs suggest low surface area when H3BO3 flux is used in the materials' synthesis, decreasing the amount of surface hydroxyl groups in Lu2O3 and improving the luminescence intensity of the phosphors. The carbon used as the susceptor generates CO gas, leading to complete reduction of Tb(IV) to Tb(3+) and partial conversion of Pr(IV) to Pr(3+) present in the Tb4O7 and Pr6O11 precursors, as indicated by X-ray absorption near-edge structure data. Persistent luminescence spectra of the materials show the red/near-IR, reddish orange, and green emission colors assigned to the 4f(n) → 4f(n) transitions characteristics of Pr(3+), Eu(3+), and Tb(3+) ions, respectively. Differences between the UV-excited and persistent luminescence spectra can be explained by the preferential persistent luminescence emission of R(3+) ion in the S6 site rather than R(3+) in the C2 site. In addition, inclusion of Hf(IV) and Ca(2+) codopants in the Lu2O3 host increases the emission intensity and duration of persistent luminescence due to generation of traps caused by charge compensation in the lattice. Photonic materials prepared by MASS with H3BO3 flux show higher persistent luminescence performance than those prepared by the ceramic method or MASS without flux. Color tuning of persistent luminescence in Lu2O3:R(3+),M provides potential

  1. Synthesis and evaluation of Lys¹(α,γ-Folate)Lys³(¹⁷⁷Lu-DOTA)-Bombesin(1-14) as a potential theranostic radiopharmaceutical for breast cancer.

    PubMed

    Aranda-Lara, Liliana; Ferro-Flores, Guillermina; Azorín-Vega, Erika; Ramírez, Flor de María; Jiménez-Mancilla, Nallely; Ocampo-García, Blanca; Santos-Cuevas, Clara; Isaac-Olivé, Keila

    2016-01-01

    The aim of this work was to synthesize Lys(1)(α,γ-Folate)-Lys(3)((177)Lu-DOTA)-Bombesin (1-14) ((177)Lu-Folate-BN), as well as to assess its potential for molecular imaging and targeted radiotherapy of breast tumors expressing folate receptors (FR) and gastrin-releasing peptide receptors (GRPR). Radiation absorbed doses of (177)Lu-Folate-BN (74 MBq, i.v.) estimated in athymic mice with T47D-induced breast tumors (positive to FR and GRPR), showed tumor doses of 23.9±2.1 Gy. T47D-tumors were clearly visible (Micro-SPECT/CT images). (177)Lu-Folate-BN demonstrated properties suitable as a theranostic radiopharmaceutical. PMID:26545016

  2. Synthesis and evaluation of Lys¹(α,γ-Folate)Lys³(¹⁷⁷Lu-DOTA)-Bombesin(1-14) as a potential theranostic radiopharmaceutical for breast cancer.

    PubMed

    Aranda-Lara, Liliana; Ferro-Flores, Guillermina; Azorín-Vega, Erika; Ramírez, Flor de María; Jiménez-Mancilla, Nallely; Ocampo-García, Blanca; Santos-Cuevas, Clara; Isaac-Olivé, Keila

    2016-01-01

    The aim of this work was to synthesize Lys(1)(α,γ-Folate)-Lys(3)((177)Lu-DOTA)-Bombesin (1-14) ((177)Lu-Folate-BN), as well as to assess its potential for molecular imaging and targeted radiotherapy of breast tumors expressing folate receptors (FR) and gastrin-releasing peptide receptors (GRPR). Radiation absorbed doses of (177)Lu-Folate-BN (74 MBq, i.v.) estimated in athymic mice with T47D-induced breast tumors (positive to FR and GRPR), showed tumor doses of 23.9±2.1 Gy. T47D-tumors were clearly visible (Micro-SPECT/CT images). (177)Lu-Folate-BN demonstrated properties suitable as a theranostic radiopharmaceutical.

  3. Role of protein farnesylation events in the ABA-mediated regulation of the Pinoresinol-Lariciresinol Reductase 1 (LuPLR1) gene expression and lignan biosynthesis in flax (Linum usitatissimum L.).

    PubMed

    Corbin, Cyrielle; Decourtil, Cédric; Marosevic, Djurdjica; Bailly, Marlène; Lopez, Tatiana; Renouard, Sullivan; Doussot, Joël; Dutilleul, Christelle; Auguin, Daniel; Giglioli-Guivarc'h, Nathalie; Lainé, Eric; Lamblin, Frédéric; Hano, Christophe

    2013-11-01

    A Linum usitatissimum LuERA1 gene encoding a putative ortholog of the ERA1 (Enhanced Response to ABA 1) gene of Arabidopsis thaliana (encoding the beta subunit of a farnesyltransferase) was analyzed in silico and for its expression in flax. The gene and the protein sequences are highly similar to other sequences already characterized in plants and all the features of a farnesyltransferase were detected. Molecular modeling of LuERA1 protein confirmed its farnesyltransferase nature. LuERA1 is expressed in the vegetative organs and also in the outer seedcoat of the flaxseed, where it could modulate the previously observed regulation operated by ABA on lignan synthesis. This effect could be mediated by the regulation of the transcription of a key gene for lignan synthesis in flax, the LuPLR1 gene, encoding a pinoresinol lariciresinol reductase. The positive effect of manumycin A, a specific inhibitor of farnesyltransferase, on lignan biosynthesis in flax cell suspension systems supports the hypothesis of the involvement of such an enzyme in the negative regulation of ABA action. In Arabidopsis, ERA1 is able to negatively regulate the ABA effects and the mutant era1 has an enhanced sensitivity to ABA. When expressed in an Arabidopsis cell suspension (heterologous system) LuERA1 is able to reverse the effect of the era1 mutation. RNAi experiments in flax targeting the farnesyltransferase β-subunit encoded by the LuERA1 gene led to an increase LuPLR1 expression level associated with an increased content of lignan in transgenic calli. Altogether these results strongly suggest a role of the product of this LuERA1 gene in the ABA-mediated upregulation of lignan biosynthesis in flax cells through the activation of LuPLR1 promoter. This ABA signaling pathway involving ERA1 probably acts through the ABRE box found in the promoter sequence of LuPLR1, a key gene for lignan synthesis in flax, as demonstrated by LuPLR1 gene promoter-reporter experiments in flax cells using wild

  4. Combination of counterpropagation artificial neural networks and antioxidant activities for comprehensive evaluation of associated-extraction efficiency of various cyclodextrins in the traditional Chinese formula Xue-Zhi-Ning.

    PubMed

    Sun, Lili; Yang, Jianwen; Wang, Meng; Zhang, Huijie; Liu, Yanan; Ren, Xiaoliang; Qi, Aidi

    2015-11-10

    Xue-Zhi-Ning (XZN) is a widely used traditional Chinese medicine formula to treat hyperlipidemia. Recently, cyclodextrins (CDs) have been extensively used to minimize problems relative to medicine bioavailability, such as low solubility and poor stability. The objective of this study was to determine the associated-extraction efficiency of various CDs in XZN. Three various type CDs were evaluated, including native CDs (α-CD, β-CD), hydrophilic CD derivatives (HP-β-CD and Me-β-CD), and ionic CD derivatives (SBE-β-CD and CM-β-CD). An ultra high-performance liquid chromatography (UHPLC) fingerprint was applied to determine the components in CD extracts and original aqueous extract (OAE). A counterpropagation artificial neural network (CP-ANN) was used to analyze the components in different extracts and compare the selective extraction of various CDs. Extraction efficiencies of the various CDs in terms of extracted components follow the ranking, ionic CD derivatives>hydrophilic CD derivatives>native CDs>OAE. Besides, different types of CDs have their own selective extraction and ionic CD derivatives present the strongest associated-extraction efficiency. Antioxidant potentials of various extracts were evaluated by determining the inhibition of spontaneous, H2O2-induced, CCl4-induced and Fe(2+)/ascorbic acid-induced lipid peroxidation (LPO) and analyzing the scavenging capacity for DPPH and hydroxyl radicals. The order of extraction efficiencies of the various CDs relative to antioxidant activities is as follows: SBE-β-CD>CM-β-CD>HP-β-CD>Me-β-CD>β-CD>α-CD. It can be demonstrated that all of the CDs studied increase the extraction efficiency and that ionic CD derivatives (SBE-β-CD and CM-β-CD) present the highest extraction capability in terms of amount extracted and antioxidant activities of extracts. PMID:26322951

  5. Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α

    PubMed Central

    Wang, Ling; Qiu, Xue-Min; Gui, Yu-Yan; Xu, Ying-Ping; Gober, Hans-Jürgen; Li, Da-Jin

    2015-01-01

    Introduction Bu-Shen-Ning-Xin decoction (BSNXD) is a traditional Chinese medicinal composition that has been used as a remedy for postmenopausal osteoporosis, but the mechanisms affecting bone metabolism are not fully understood. Purpose We investigated the molecular mechanism and signaling pathway underlying the effect of BSNXD on osteoclastogenesis. Materials and methods A postmenopausal osteoporosis animal model generated by ovariectomy was administered BSNXD and drug-derived serum was prepared. An enzyme immunoassay was conducted to measure the 17-β-estradiol (E2) concentration in the drug-derived serum. Bone marrow-derived monocyte/macrophage precursor cells were treated with drug-derived serum, and tartrate-resistance acid phosphatase staining was conducted to observe osteoclastogenesis. A bone resorption assay was performed to analyze the effect on osteoclastic resorptive function. Real-time PCR, flow cytometry, Western blotting, transfection, and luciferase assays were conducted to explore the related mechanism. Results E2 was not elevated in BSNXD-derived serum. BSNXD-derived serum suppressed receptor activation of nuclear factor κB ligand (RANKL)-activated osteoclastogenesis in a dose-dependent manner; this effect could be reversed by estrogen receptor α antagonist methyl-piperidino-pyrazole. The serum suppressed RANKL-induced NF-κB transcription and inhibited the accumulation of nuclear factor of activated T-cells, cytoplasmic 1 in osteoclast precursor cells; the inhibitory effect was abolished by methyl-piperidino-pyrazole but not the estrogen receptor β antagonist or androgen receptor antagonist. Conclusion These results collectively suggest that administration of BSNXD presents inhibitory effects on osteoclast differentiation by abrogating the RANKL-induced nuclear factor of activated T-cells, cytoplasmic 1 and NF-κB signaling pathways downstream of estrogen receptor α, thereby contributing to the inhibitory effect on bone resorption. PMID

  6. Combination of counterpropagation artificial neural networks and antioxidant activities for comprehensive evaluation of associated-extraction efficiency of various cyclodextrins in the traditional Chinese formula Xue-Zhi-Ning.

    PubMed

    Sun, Lili; Yang, Jianwen; Wang, Meng; Zhang, Huijie; Liu, Yanan; Ren, Xiaoliang; Qi, Aidi

    2015-11-10

    Xue-Zhi-Ning (XZN) is a widely used traditional Chinese medicine formula to treat hyperlipidemia. Recently, cyclodextrins (CDs) have been extensively used to minimize problems relative to medicine bioavailability, such as low solubility and poor stability. The objective of this study was to determine the associated-extraction efficiency of various CDs in XZN. Three various type CDs were evaluated, including native CDs (α-CD, β-CD), hydrophilic CD derivatives (HP-β-CD and Me-β-CD), and ionic CD derivatives (SBE-β-CD and CM-β-CD). An ultra high-performance liquid chromatography (UHPLC) fingerprint was applied to determine the components in CD extracts and original aqueous extract (OAE). A counterpropagation artificial neural network (CP-ANN) was used to analyze the components in different extracts and compare the selective extraction of various CDs. Extraction efficiencies of the various CDs in terms of extracted components follow the ranking, ionic CD derivatives>hydrophilic CD derivatives>native CDs>OAE. Besides, different types of CDs have their own selective extraction and ionic CD derivatives present the strongest associated-extraction efficiency. Antioxidant potentials of various extracts were evaluated by determining the inhibition of spontaneous, H2O2-induced, CCl4-induced and Fe(2+)/ascorbic acid-induced lipid peroxidation (LPO) and analyzing the scavenging capacity for DPPH and hydroxyl radicals. The order of extraction efficiencies of the various CDs relative to antioxidant activities is as follows: SBE-β-CD>CM-β-CD>HP-β-CD>Me-β-CD>β-CD>α-CD. It can be demonstrated that all of the CDs studied increase the extraction efficiency and that ionic CD derivatives (SBE-β-CD and CM-β-CD) present the highest extraction capability in terms of amount extracted and antioxidant activities of extracts.

  7. Electronic structure, optical and thermal/concentration quenching properties of Lu{sub 2−2x}Eu{sub 2x}WO{sub 6} (0 ≤ x ≤0.2)

    SciTech Connect

    Chen, Xiang-Yang; Zhang, Zhi-Jun; Feng, Ang; Xu, Meng; Zhao, Jing-Tai; Xu, Fang-Fang

    2015-10-15

    Highlights: • The band gap of Lu{sub 2}WO{sub 6} is calculated to be 3.13 eV using the CASTEP mode. • Valent state and occupation site of Eu are clarified by X-ray absorption fine structure (XAFS) spectra. • The thermal/concentration quenching mechanisms of Eu in Lu{sub 2}WO{sub 6} have been investigated in detail. - Abstract: Density functional theory calculations on monoclinic Lu{sub 2}WO{sub 6} is carried out using the Cambridge Sequential Total Energy Package code. The result indicates that Lu{sub 2}WO{sub 6} is a broad band gap semiconductor with an indirect band gap of 3.13 eV. Eu ions are trivalency and the average coordination number is 7.6(5), indicating that the site of Lu is occupied by Eu. The activation energy ΔE is calculated as 0.314 eV. In addiation, the thermal quenching mechnism of Eu-activated Lu{sub 2}WO{sub 6} and the different concentration quenching mechanisms for {sup 5}D{sub 0} and {sup 5}D{sub 1} emissions of Eu ions have been proposed.

  8. All-solid-state continuous-wave frequency doubling Nd:LuVO4/LBO laser with 2.17 W output power at 543 nm

    NASA Astrophysics Data System (ADS)

    Li, B.; Zhao, L.; Zhang, Y. B.; Zheng, Q.; Zhao, Y.; Yao, Y.

    2013-03-01

    Efficient and compact green-yellow laser output at 543 nm is generated by intracavity frequency doubling of a CW diode-pumped Nd:LuVO4 laser at 1086 nm under the condition of suppressing the higher gain transition near 1064 nm. With 16 W of diode pump power and the frequency-doubling crystal LBO, as high as 2.17 W of CW output power at 543 nm is achieved, corresponding to an optical-to-optical conversion efficiency of 13.6% and the output power stability over 8 hours is better than 2.86%. To the best of our knowledge, this is the highest watt-level laser at 543 nm generated by intracavity frequency doubling of a diode pumped Nd:LuVO4 laser at 1086 nm.

  9. On the effective implementation of a boundary element code on graphics processing units unsing an out-of-core LU algorithm

    SciTech Connect

    D'Azevedo, Ed F; Nintcheu Fata, Sylvain

    2012-01-01

    A collocation boundary element code for solving the three-dimensional Laplace equation, publicly available from \\url{http://www.intetec.org}, has been adapted to run on an Nvidia Tesla general purpose graphics processing unit (GPU). Global matrix assembly and LU factorization of the resulting dense matrix were performed on the GPU. Out-of-core techniques were used to solve problems larger than available GPU memory. The code achieved over eight times speedup in matrix assembly and about 56~Gflops/sec in the LU factorization using only 512~Mbytes of GPU memory. Details of the GPU implementation and comparisons with the standard sequential algorithm are included to illustrate the performance of the GPU code.

  10. Performance of the Yb:Lu2O3 laser crystal in diode-pumped femtosecond oscillators and high-power regenerative amplifiers

    NASA Astrophysics Data System (ADS)

    Caracciolo, E.; Pirzio, F.; Kemnitzer, M.; Guandalini, A.; Kienle, F.; Agnesi, A.; Aus der Au, J.

    2016-03-01

    We investigated the performance of the laser gain medium Yb:Lu2O3 in a low-power oscillator and a high-power regenerative amplifier. Almost Fourier transform limited 78-fs pulses were demonstrated in the low-power, SESAM mode-locked oscillator pumped with a single-mode fiber-coupled laser diode. Exploiting the excellent thermomechanical properties of Yb:Lu2O3, we were able to achieve up to 22.2 W of average output power at a repetition rate of 500 kHz and 670-fs long pulses with the regenerative bulk amplifier. Experiments on further power up-scaling and pulse duration shortening are in progress. Up to 65 W were already proved in preliminary tests in cw regime.

  11. Crystal structure and properties of high-pressure-synthesized BiRhO{sub 3}, LuRhO{sub 3}, and NdRhO{sub 3}

    SciTech Connect

    Yi, Wei; Liang, Qifeng; Matsushita, Yoshitaka; Tanaka, Masahiko; Hu, Xiao; Belik, Alexei A.

    2013-04-15

    GdFeO{sub 3}-type orthorhombic perovskite compounds BiRhO{sub 3}, LuRhO{sub 3}, and NdRhO{sub 3} were prepared using a high-pressure and high-temperature technique at 6 GPa and 1300–1600 K. Their crystal structures were investigated using synchrotron X-ray powder diffraction data: a=5.8098(3) Å, b=7.7720(4) Å, and c=5.3510(3) Å for BiRhO{sub 3}; a=5.75519(1) Å, b=7.77218(2) Å, and c=5.37572(1) Å for NdRhO{sub 3}, and a=5.66981(1) Å, b=7.51205(2) Å, and c=5.18520(1) Å for LuRhO{sub 3}. BiRhO{sub 3} crystallizes in the centrosymmetric space group Pnma (No. 62) similar to LuRhO{sub 3} and NdRhO{sub 3} despite the presence of the lone electron pair of Bi{sup 3+} and the non-magnetic ground state of Rh{sup 3+}. BiRhO{sub 3} and LuRhO{sub 3} are non-magnetic, and NdRhO{sub 3} shows paramagnetic behavior from Nd{sup 3+} ions. The specific heat of BiRhO{sub 3}, LuRhO{sub 3}, and NdRhO{sub 3} in different applied magnetic fields was also investigated. An energy gap of BiRhO{sub 3} was estimated to be about 1.3 eV from diffuse reflectance spectra and 0.95 eV from first-principle calculations with U=3.5 eV. - Graphical abstract: A fragment of the crystal structure of BiRhO{sub 3} in the Pnma (along b axis) model, 2×2×2 unit cell. The RhO{sub 6} octahedra are shown in gray. The Bi atoms are shown by big black circles. Highlights: ► BiRhO{sub 3}, LuRhO{sub 3}, and NdRhO{sub 3} were prepared using a high-pressure technique. ► Structure of three compounds was determined: centrosymmetric space group Pnma. ► BiRhO{sub 3} and LuRhO{sub 3} are non-magnetic, and NdRhO{sub 3} shows paramagnetic behavior. ► Specific heat of BiRhO{sub 3}, LuRhO{sub 3}, and NdRhO{sub 3} was investigated. ► BiRhO{sub 3} has an energy gap of about 1.3 eV.

  12. Growth mode and self-organization of LuPc2 on Si(001)-2×1 vicinal surfaces: An optical investigation

    NASA Astrophysics Data System (ADS)

    Boudet, S.; Bidermane, I.; Lacaze, E.; Gallas, B.; Bouvet, M.; Brunet, J.; Pauly, A.; Borensztein, Y.; Witkowski, N.

    2012-09-01

    We report an investigation of the initial growth and of the self-organization of lutetium biphthalocyanine LuPc2 on Si(001)-2×1 vicinal surfaces. Using surface-sensitive optical spectroscopies, namely, surface-difference-reflectance spectroscopy (SDRS) and reflectance-anisotropy spectroscopy (RAS), together with local-probe microscopies, we are able to propose a scenario for the growth mode up to about 20 nm. We demonstrate that the growth mode initially proceeds through the formation of a wetting layer, followed by the formation of clusters whose sizes increase while keeping a constant shape in which the molecules are inclined. Moreover, the LuPc2 molecules are self-organized along the step edges, and we are able to estimate that about 30% to 100% of the molecules are aligned when considering that the molecules are tilted by 45∘ to 63∘ with respect to the surface normal.

  13. Ab initio determination of spin Hamiltonians with anisotropic exchange interactions: The case of the pyrochlore ferromagnet Lu2V2O7

    NASA Astrophysics Data System (ADS)

    Riedl, Kira; Guterding, Daniel; Jeschke, Harald O.; Gingras, Michel J. P.; Valentí, Roser

    2016-07-01

    We present a general framework for deriving effective spin Hamiltonians of correlated magnetic systems based on a combination of relativistic ab initio density functional theory calculations, exact diagonalization of a generalized Hubbard Hamiltonian on finite clusters, and spin projections onto the low-energy subspace. A key motivation is to determine anisotropic bilinear exchange couplings in materials of interest. As an example, we apply this method to the pyrochlore Lu2V2O7 where the vanadium ions form a lattice of corner-sharing spin-1/2 tetrahedra. In this compound, anisotropic Dzyaloshinskii-Moriya interactions (DMIs) play an essential role in inducing a magnon Hall effect. We obtain quantitative estimates of the nearest-neighbor Heisenberg exchange, the DMI, and the symmetric part of the anisotropic exchange tensor. Finally, we compare our results with experimental ones on the Lu2V2O7 compound.

  14. Heteroepitaxy of single-crystal LaLuO{sub 3} on GaAs(111)A by atomic layer deposition

    SciTech Connect

    Liu Yiqun; Heo, Jaeyeong; Gordon, Roy G.; Xu Min; Ye, Peide D.

    2010-10-18

    We demonstrate that LaLuO{sub 3} films can be grown epitaxially on sulfur-passivated GaAs(111)A substrates by atomic layer deposition (ALD). Transmission electron microscopy and x-ray diffraction analyses reveal that the oxide film exhibits a cubic structure with a lattice mismatch of -3.8% relative to GaAs. The epitaxial layer has a high degree of crystalline perfection and is relaxed. Electrical characterizations performed on this structure show interfaces with a low interface state density of {approx}7x10{sup 11} cm{sup -2} eV{sup -1}. The measured dielectric constant is around 30, which is close to its bulk crystalline value. In contrast, ALD LaLuO{sub 3} is polycrystalline on GaAs(100) and amorphous on Si(111).

  15. Crystal structure, magnetic and dielectric behavior of h-LuMnxO3±δ ceramics (0.95≤x≤1.04)

    NASA Astrophysics Data System (ADS)

    Baghizadeh, A.; Vieira, J. M.; Amaral, J. S.; Graça, M. P.; Soares, M. R.; Mota, D. A.; Amaral, V. S.

    2015-12-01

    Lattice constants, magnetic properties and dielectric behavior of h-LuMnxO3±δ solid solution (0.95≤x≤1.04) of bulk ceramic samples prepared by the solid state reaction method were studied to determine the role of stoichiometry changes on the crystalline structure and magneto-electric coupling. It is found that increasing of Mn content results in reduction of cell volume of h-LuMnxO3±δ ceramics mostly due to shrinkage of a-axis length. The antiferromagnetic interactions of Mn3+ ions weaken with cell volume contraction. A weak ferromagnetic contribution appeared in all samples and extends up to the Neel temperature, TN. Irreversibility in temperature dependent magnetic measurements already reported for stoichiometric compositions of hexagonal RMnO3 oxides appears for all h-LuMnxO3±δ samples right below Neel ordering transition. An increase of magnetic coercive field and magnetization on cooling below TN in samples is observed in field dependent magnetization and rises as x increases. In addition to the antiferromagnetic ordering transition at TN, two anomalies of the temperature dependent magnetic susceptibility and dielectric constant are identified below TN, centered at 69 K and 31 K respectively, being probably due to inhomogeneity of the crystalline structure inside ceramic grains. Changes of the dielectric constant at TN can be attributed to magneto-electric coupling in the off-stoichiometric hexagonal LuMnxO3±δ lattice. The behavior of the dielectric relaxation follows a thermally activated mechanism with activation energy values characteristic of polaron hoping.

  16. Temperature dependence of the radiation tolerance of nanocrystalline pyrochlores A2Ti2O7 (A = Gd, Ho and Lu)

    DOE PAGES

    Wen, J.; Sun, C.; Dholabhai, P. P.; Xia, Y.; Tang, M.; Chen, D.; Yang, D. Y.; Li, Y. H.; Uberuaga, B. P.; Wang, Y. Q.

    2016-03-21

    A potentially enhanced radiation resistance of nanocrystalline materials, as a consequence of the high density of interfaces and surfaces, has attracted much attention both to understand the fundamental role of these defect sinks and to develop them for high-radiation environments. Here, irradiation response of nanocrystalline A2Ti2O7 (A = Gd, Ho and Lu) pyrochlore powders with grain sizes of 20–30 nm was investigated by 1-MeV Kr2+ ion bombardment. In situ transmission electron microscopy (TEM) revealed that the critical amorphization fluence for each nanocrystalline compound at room temperature was greater than that for their coarse-grained counterparts, indicating an enhanced amorphization resistance. Themore » effect of temperature on the irradiation response of one of these compounds, nanocrystalline Lu2Ti2O7, was further examined by performing ion irradiation at an elevated temperature range of 480–600 K. The critical amorphization temperature (Tc) was found to be noticeably higher in nanocrystalline Lu2Ti2O7 (610 K) than its coarse-grained counterpart (480 K), revealing that nanocrystalline Lu2Ti2O7 is less resistant to amorphization compared to its coarse-grained phase under high temperatures. We interpret these results with the aid of atomistic simulations. Molecular statics calculations find that cation antisite defects are less energetically costly to form near surfaces than in the bulk, suggesting that the nanocrystalline form of these materials is generally less susceptible to amorphization than coarse-grained counterparts at low temperatures where defect kinetics are negligible. In contrast, at high temperatures, the annealing efficiency of antisite defects by cation interstitials is significantly reduced due to the sink properties of the surfaces in the nanocrystalline pyrochlore, which contributes to the observed higher amorphization temperature in the nano-grained phase than in coarse-grained counterpart. Altogether, these results provide new

  17. Nine members of a family of nine-membered cyclic coordination clusters; Fe6Ln3 wheels (Ln = Gd to Lu and Y).

    PubMed

    Kühne, Irina A; Mereacre, Valeriu; Anson, Christopher E; Powell, Annie K

    2016-01-18

    We report a family of isostructural nonanuclear Fe(III)-Ln(III) cyclic coordination clusters [Fe(III)(6)Ln(III)(3)(μ-OMe)9(vanox)6(benz)6]. (Ln = Tb (1), Dy (2), Ho (3), Er (4), Tm (5), Yb (6), Lu (7), Y (8) and Gd (9)), containing an odd number of metal ions. The planar cyclic coordination cluster cores are built up from three [Fe2Ln] subunits.

  18. Implementing Room-Temperature Multiferroism by Exploiting Hexagonal-Orthorhombic Morphotropic Phase Coexistence in LuFeO3 Thin Films.

    PubMed

    Song, Seungwoo; Han, Hyeon; Jang, Hyun Myung; Kim, Young Tae; Lee, Nam-Suk; Park, Chan Gyung; Kim, Jeong Rae; Noh, Tae Won; Scott, James F

    2016-09-01

    Room-temperature multiferroism in LuFeO3 (LFO) films is demonstrated by exploiting the orthorhombic-hexagonal (o-h) morphotrophic phase coexistence. The LFO film further reveals a magnetoelectric coupling effect that is not shown in single-phase (h- or o-) LFO. The observed multiferroism is attributed to the combination of sufficient polarization from h-LFO and net magnetization from o-LFO.

  19. Metastasizing, Luciferase Transduced MAT-Lu Rat Prostate Cancer Models: Follow up of Bolus and Metronomic Therapy with Doxorubicin as Model Drug

    PubMed Central

    Jantscheff, Peter; Esser, Norbert; Geipel, Andreas; Woias, Peter; Ziroli, Vittorio; Goldschmidtboing, Frank; Massing, Ulrich

    2011-01-01

    The most fatal outcomes of prostate carcinoma (PCa) result from hormone-refractory variants of the tumor, especially from metastatic spread rather than from primary tumor burden. The goal of the study was to establish and apply rat MAT-Lu prostate cancer tumor models for improved non-invasive live follow up of tumor growth and metastasis by in vivo bioluminescence. We established luciferase transduced MAT-Lu rat PCa cells and studied tumor growth and metastatic processes in an ectopic as well as orthotopic setting. An intravenous bolus treatment with doxorubicin was used to demonstrate the basic applicability of in vivo imaging to follow up therapeutic intervention in these models. In vitro analysis of tissue homogenates confirmed major metastatic spread of subcutaneous tumors into the lung. Our sensitive method, however, for the first time detects metastasis also in lymph node (11/24), spleen (3/24), kidney (4/24), liver (5/24), and bone tissue (femur or spinal cord - 5/20 and 12/20, respectively). Preliminary data of orthotopic implantation (three animals) showed metastatic invasion to investigated organs in all animals but with varying preference (e.g., to lymph nodes). Intravenous bolus treatment of MAT-Lu PCa with doxorubicin reduced subcutaneous tumor growth by about 50% and the number of animals affected by metastatic lesions in lymph nodes (0/4), lung (3/6) or lumbar spine (0/2), as determined by in vivo imaging and in vitro analysis. Additionally, the possible applicability of the luciferase transduced MAT-Lu model(s) to study basic principles of metronomic therapies via jugular vein catheter, using newly established active microport pumping systems, is presented. PMID:24212827

  20. Radioimmunotherapy of Metastatic Prostate Cancer with ¹⁷⁷Lu-DOTAhuJ591 Anti Prostate Specific Membrane Antigen Specific Monoclonal Antibody.

    PubMed

    Vallabhajosula, Shankar; Nikolopoulou, Anastasia; Jhanwar, Yuliya S; Kaur, Gurveen; Tagawa, Scott T; Nanus, David M; Bander, Neil H; Goldsmith, Stanley J

    2016-01-01

    Prostate specific membrane antigen (PSMA) is the single most well-validated prostate cancer (PCa)-specific cell membrane antigen known. It is present in high levels in 95% of PCa, and is an ideal target to develop radiopharmaceuticals for imaging studies and radionuclide therapy. Humanized J591 monoclonal antibody (mAb) binds specifically with nanomolar affinity to the extracellular domain of PSMA. After binding, the PSMA-antibody complex is rapidly internalized, increasing the potential utility of PSMA as a target for the delivery of mAb-conjugated radionuclides or cytotoxins. J591 mAb was labeled with 177Lu at a high specific activity (10-30 mCi/mg) using DOTA as the bifunctional chelate. The preclinical data in PSMA positive xenografts, strongly suggested that 177;Lu-J591 mAb is an ideal radiopharmaceutical for RIT of metastatic PCa. Since October 2000, five clinical studies (phase I and II) were performed in subjects with metastatic castration-resistant prostate cancer (CRPC) using 177Lu-J591. The methodology and the results of these clinical studies are briefly reviewed in this article. The maximum tolerated dose (MTD) as a single dose was 70 mCi2. Based on dose fractionation (DF), MTD was 90 mCi/m2(2 doses of 45 mCi/m2, 2 wks apart). Phase II study in patients with progressive metastatic CRPC, at a dose of 65- 70 mCi/m2 resulted in significant PSA declines in 60% of the patients. While myelosuppression was the dose limiting toxicity, DF alone or in combination with docetaxel also resulted in significant PSA declines with much less toxicity. 177Lu imaging studies demonstrated accurate targeting of known metastatic sites in >90% of patients and those with stronger PSMA expression by semi-quantitative imaging had more PSA declines. These clinical studies clearly documented the potential therapeutic value of radioimmunotherapy (RIT) in metastatic PCa.