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Sample records for ning lu laureano

  1. Crossing Cultural Borders through Ning

    ERIC Educational Resources Information Center

    Eamer, Allyson; Hughes, Janette; Morrison, Laura Jane

    2014-01-01

    The aim of this mixed methods research study was to examine the construction of adolescents' bi-cultural identities through an exploration of their social practices on the social networking site, Ning. More specifically, we ask: (1) how are new Canadian and first-generation adolescents' bi-cultural identities shaped and performed as they use…

  2. Ning and Writing to Learn

    ERIC Educational Resources Information Center

    Ettzevoglou, Nathalie; McBride, Jessica

    2009-01-01

    Writing effectively is academically and professionally crucial for students, and helping them attain that skill is a major goal for writing instruction. The social networking site Ning offers a variety of Web 2.0 tools that can help students learn to write as well as write to learn. In this article, the authors describe their personal experiment…

  3. Educators Eye Ning Transition to a Pay Model

    ERIC Educational Resources Information Center

    Davis, Michelle R.

    2010-01-01

    The author reports on a move by the online social-networking site Ning to start charging for its services which has raised worries that new fees could stifle educators' technological collaboration and creativity and touch off similar moves by other companies that provide comparable services heavily used by educators. Ning, which provides a…

  4. Educators Eye Ning Transition to a Pay Model

    ERIC Educational Resources Information Center

    Davis, Michelle R.

    2010-01-01

    The author reports on a move by the online social-networking site Ning to start charging for its services which has raised worries that new fees could stifle educators' technological collaboration and creativity and touch off similar moves by other companies that provide comparable services heavily used by educators. Ning, which provides a…

  5. The MueLu Tutorial

    SciTech Connect

    Hu, Jonathan Joseph; Wiesner, Tobias A.; Prokopenko, Andrey; Gee, Michael

    2014-10-01

    The MueLu tutorial is written as a hands-on tutorial for MueLu, the next generation multigrid framework in Trilinos. It covers the whole spectrum from absolute beginners’ topics to expert level. Since the focus of this tutorial is on practical and technical aspects of multigrid methods in general and MueLu in particular, the reader is expected to have a basic understanding of multigrid methods and its general underlying concepts. Please refer to multigrid textbooks (e.g. [1]) for the theoretical background.

  6. Beauty and physics: 13 important contributions of Chen Ning Yang

    NASA Astrophysics Data System (ADS)

    Shi, Yu

    2014-06-01

    In 2012, Chen Ning Yang received a 90th birthday gift in the form of a black cube inscribed with his 13 most important contributions, which cover four major areas of physics: statistical mechanics, condensed matter physics, particle physics and field theory. We briefly describe these 13 contributions and make general comments about Yang's distinctive style as a trailblazing leader in research.

  7. Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism.

    PubMed

    El Nemer, W; Rahuel, C; Colin, Y; Gane, P; Cartron, J P; Le Van Kim, C

    1997-06-15

    The Lutheran (Lu) blood group antigens and the B-cell adhesion molecule (B-CAM) epithelial cancer antigen are carried by recently cloned integral glycoproteins that belong to the Ig superfamily. We have previously shown that the Lu and B-CAM antigens are encoded by the same gene, LU, and that alternative splicing of the primary transcript most likely accounts for the presence of both antigens on two isoforms that differ by the length of their cytoplasmic tails. In the present report, we isolated the human LU gene by cloning a 20-kb HindIII fragment from Lu(a - b+) genomic DNA. The LU gene is organized into 15 exons distributed over 12.5 kb. Alternative splicing of intron 13 generates the 2.5- and 4.0-kb transcript spliceoforms encoding the long tail and the short tail Lu polypeptides, respectively. Sequencing of the major mRNA species (2.5 kb) amplified from human bone marrow, kidney, placenta, and skeletal muscle did not suggest the presence of tissue-specific Lu glycoprotein isoforms. The same transcription initiation point, located 22 bp upstream from the initiation codon, was characterized in several tissues. In agreement with the wide tissue distribution of the Lu messengers, the GC-rich proximal 5' flanking region of the LU gene does not contain TATA or CAAT boxes, but includes several potential binding sites for the ubiquitous Sp1 transcription factor. In addition, the distal 5' region, encompassing nucleotides -673 to -764, contains clustered binding sequences for the GATA, CACCC, and Ets transcription factors. Analysis of the coding sequences amplified from genomic DNA of Lu(a + b-) or Lu(a - b+) donors showed a single nucleotide change in exon 3 (A229G) that correlates with an Aci I restriction site polymorphism and results in a His77Arg amino-acid substitution. Polymerase chain reaction/restriction fragment length polymorphism analysis indicated that the A229G mutation is associated with the Lu(a)/Lu(b) blood group polymorphism. When expressed in Chinese

  8. Consequences of meta-stable (177m)Lu admixture in (177)Lu for patient dosimetry.

    PubMed

    Konijnenberg, Mark W

    2015-01-01

    Lutetium-177 ((177)Lu) is a rare earth metal in the lanthanides series which decays by beta emission with a half life of 6.647 days to three excited states and the ground state of (177)Hf. When (177)Lu is produced by neutron capture in (176)Lu, inevitably an admixture is formed of the long-lived isomer (177)mLu. As its half-life of 160.4 days is so much longer than that of (177)Lu, concerns are raised on its possible enhancement in radiation dose to the patient treated with (177)Lu-DOTA-octreotate. This report evaluates this possible enhancement of the absorbed dose, based on the published pharmacokinetic profile of (177)Lu-DOTA-octreotate and assuming an admixture of 1 kBq (177)mLu /MBq (177)Lu (0.1%).

  9. TU(R)NING WEAKNESS TO STRENGTH MECHANOMUTABLE BIOINSPIRED MATERIALS

    DTIC Science & Technology

    2017-04-03

    AFRL-AFOSR-VA-TR-2017-0067 TU(R)NING WEAKNESS TO STRENGTH - MECHANOMUTABLE BIOINSPIRED MATERIALS Markus Buehler MASSACHUSETTS INSTITUTE OF... MATERIALS 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA9550-11-1-0199 5c.  PROGRAM ELEMENT NUMBER 61102F 6.  AUTHOR(S) Markus Buehler 5d.  PROJECT NUMBER...proving both the nanoscale mechanisms and mechanical behavior predictions. 15.  SUBJECT TERMS hybrid materials , low density materials 16.  SECURITY

  10. A diagonally inverted LU implicit multigrid scheme

    NASA Technical Reports Server (NTRS)

    Yokota, Jeffrey W.; Caughey, David A.; Chima, Rodrick V.

    1988-01-01

    A new Diagonally Inverted LU Implicit scheme is developed within the framework of the multigrid method for the 3-D unsteady Euler equations. The matrix systems that are to be inverted in the LU scheme are treated by local diagonalizing transformations that decouple them into systems of scalar equations. Unlike the Diagonalized ADI method, the time accuracy of the LU scheme is not reduced since the diagonalization procedure does not destroy time conservation. Even more importantly, this diagonalization significantly reduces the computational effort required to solve the LU approximation and therefore transforms it into a more efficient method of numerically solving the 3-D Euler equations.

  11. The electronic structure of Lu

    NASA Astrophysics Data System (ADS)

    Tibbetts, T. A.; Harmon, B. N.

    1982-12-01

    The electronic structure of hcp Lu has been calculated using a linearized augmented plane wave (LAPW) method and the Hedin-Lundqvist local density approximation for exchange and correlation. Although complete self-consistency was hindered by the proximity of the 4f levels to the Fermi energy, the valence bands were converged and the calculation yielded a Fermi surface remarkably similar to that calculated by Keeton and Loucks. Comparison is made with recent de Haas-van Alphen and neutron magnetic form factor experiments.

  12. SuperLU users' guide

    SciTech Connect

    Demmel, James W.; Gilbert, John R.; Li, Xiaoye S.

    1999-11-01

    This document describes a collection of three related ANSI C subroutine libraries for solving sparse linear systems of equations AX = B: Here A is a square, nonsingular, n x n sparse matrix, and X and B are dense n x nrhs matrices, where nrhs is the number of right-hand sides and solution vectors. Matrix A need not be symmetric or definite; indeed, SuperLU is particularly appropriate for matrices with very unsymmetric structure. All three libraries use variations of Gaussian elimination optimized to take advantage both of sparsity and the computer architecture, in particular memory hierarchies (caches) and parallelism.

  13. Expedition 7 Crew Interview: Ed Lu

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Ed Lu of Expedition Seven is seen during a pre-launch interview. He explains why he became interested in space flight. He states that this is a different type of mission and gives his reaction to the Columbia Space Shuttle tragedy. The handover of Expedition six is explained by Ed Lu. The challenges of this mission are also described by Lu. These challenges include working with a crew member reduction from three to two, and the conservation of clothing and consumables. Ed Lu talks about what it is like to work with commander Yuri Malenchenko in space. Finally, Ed Lu states that he will continue scientific experiments in space on calcium loss in bones.

  14. Expedition 7 Crew Interview: Ed Lu

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Ed Lu of Expedition Seven is seen during a pre-launch interview. He explains why he became interested in space flight. He states that this is a different type of mission and gives his reaction to the Columbia Space Shuttle tragedy. The handover of Expedition six is explained by Ed Lu. The challenges of this mission are also described by Lu. These challenges include working with a crew member reduction from three to two, and the conservation of clothing and consumables. Ed Lu talks about what it is like to work with commander Yuri Malenchenko in space. Finally, Ed Lu states that he will continue scientific experiments in space on calcium loss in bones.

  15. Lu2@C2n (2n = 82, 84, 86): Crystallographic Evidence of Direct Lu-Lu Bonding between Two Divalent Lutetium Ions Inside Fullerene Cages.

    PubMed

    Shen, Wangqiang; Bao, Lipiao; Wu, Yongbo; Pan, Changwang; Zhao, Shasha; Fang, Hongyun; Xie, Yunpeng; Jin, Peng; Peng, Ping; Li, Fang-Fang; Lu, Xing

    2017-07-26

    Although most of the M2C2n-type metallofullerenes (EMFs) tend to form carbide cluster EMFs, we report herein that Lu-containing EMFs Lu2C2n (2n = 82, 84, 86) are actually dimetallofullerenes (di-EMFs), namely, Lu2@Cs(6)-C82, Lu2@C3v(8)-C82, Lu2@D2d(23)-C84, and Lu2@C2v(9)-C86. Unambiguous X-ray results demonstrate the formation of a Lu-Lu single bond between two lutetium ions which transfers four electrons in total to the fullerene cages, thus resulting in a formal divalent state for each Lu ion. Population analysis indicates that each Lu atom formally donates a 5d electron and a 6s electron to the cage with the remaining 6s electron shared with the other Lu atom to form a Lu-Lu single bond so that only four electrons are transferred to the fullerene cages with the formal divalent valence for each lutetium ion. Accordingly, we confirmed both experimentally and theoretically that the dominating formation of di-EMFs is thermodynamically very favorable for Lu2C2n isomers.

  16. THE LU ISOTOPIC COMPOSITION OF ACHONDRITES: CLOSING THE CASE FOR ACCELERATED DECAY OF {sup 176}LU

    SciTech Connect

    Wimpenny, Josh; Yin, Qing-zhu; Amelin, Yuri

    2015-10-10

    Studies of Lu–Hf isotope systematics in meteorites have produced apparent “ages” that are older than Pb–Pb ages and older than the estimated age of our solar system. One proposed explanation for this discrepancy is that irradiation by cosmic rays caused excitation of {sup 176}Lu to its short-lived isomer that then underwent rapid decay to {sup 176}Hf. This explanation can account for apparent excesses in {sup 176}Hf that correlate with Lu/Hf ratio. Mass balance requires that samples with measurable excess in {sup 176}Hf should also have measurable deficiencies in {sup 176}Lu on the order of 1‰–3‰. To unambiguously test the accelerated decay hypothesis, we have measured the {sup 176}Lu/{sup 175}Lu ratio in terrestrial materials and achondrites to search for evidence of depletion in {sup 176}Lu. To a precision of 0.1‰ terrestrial standards, cumulate and basaltic eucrites and angrites all have the same {sup 176}Lu/{sup 175}Lu ratio. Barring a subsequent mass-dependent fractionation event, these results suggest that the apparent excesses in {sup 176}Hf are not caused by accelerated decay of {sup 176}Lu, and so another hypothesis is required to explain apparently old Lu–Hf ages.

  17. Expedition Seven Science Officer Lu with laptop

    NASA Image and Video Library

    2003-07-16

    ISS007-E-10478 (16 July 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, uses a computer in the Destiny laboratory on the International Space Station (ISS).

  18. STS-106 Crew Interviews: Edward T. Lu

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Live footage of a preflight interview with Mission Specialist Edward T. Lu is seen. The interview addresses many different questions including why Lu became interested in the space program, the events that led to his interest, the transition from an engineer to research scientist, and finally to getting selected into the astronaut program. Other interesting information that this one-on-one interview discusses are the main goals of the STS-106 mission, its scheduled docking with the new International Space Station (ISS), making the Zvezda Service Module ready for entrance, and crew training both in the United States and Russia. Lu mentions his responsibilities during the much-anticipated docking as well as his scheduled space-walk with Yuri Ivanovich Malenchenko. Lu also discusses the use of the Robotic Arm during his space-walk, installation of a magnetometer on the Zvezda Module, and work that will have to take place inside the Service Module.

  19. Lu plays with a droplet of liquid

    NASA Image and Video Library

    2003-10-25

    ISS007-E-17985 (2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, watches a water bubble float between him and the camera, showing his image refracted, on the International Space Station (ISS).

  20. Quantitative SPECT/CT reconstruction for 177Lu and 177Lu/90Y targeted radionuclide therapies

    NASA Astrophysics Data System (ADS)

    Shcherbinin, S.; Piwowarska-Bilska, H.; Celler, A.; Birkenfeld, B.

    2012-09-01

    We investigated the quantitative accuracy of SPECT/CT imaging studies as would be performed before and after targeted radionuclide therapy (TRT) using phantom experiments with (i) 99mTc, (ii) 177Lu and (iii) 90Y/177Lu. While the experiment with 99mTc imitated a diagnostic scan, the experiments with 177Lu and 90Y/177Lu modeled post-therapy acquisitions. At the next stage, we reconstructed images from pre- and post-therapy patient studies. The data were first reconstructed using two methods with limited corrections for the physics effects. Then, to generate quantitatively accurate absolute activity distributions, we applied a hybrid (model-based and window-based) reconstruction strategy where some of the physics effects were accurately modeled while corrections for other effects were empirical and based on information obtained from the projection data. The accuracies of absolute activity recovered by the hybrid method from the six phantom experiments were very similar to each other and acceptable for potential use in TRT. When measured in identical regions of interest, the 99mTc activity was reconstructed with errors ranging between -3.3% and 2.9%, while the 177Lu activity was reconstructed from experiments with 177Lu and 90Y/177Lu with errors ranging between -1.6% and 1.6%. The reconstruction algorithms with limited corrections led to larger and case-specific errors as might have been expected. From a clinical prospective, our results showed that physics-based reconstructions improved resolution of images corresponding to both diagnostic scans with 99mTc and post-therapy scans with 177Lu. Our analysis of patient study demonstrated that lack of corrections led to overestimation of activities in organs and tumor by 29-39% for the diagnostic scan with 99mTc and by 105-218% for post-therapy scan with 177Lu.

  1. Method for preparing high specific activity 177Lu

    DOEpatents

    Mirzadeh, Saed; Du, Miting; Beets, Arnold L.; Knapp, Jr., Furn F.

    2004-04-06

    A method of separating lutetium from a solution containing Lu and Yb, particularly reactor-produced .sup.177 Lu and .sup.177 Yb, includes the steps of: providing a chromatographic separation apparatus containing LN resin; loading the apparatus with a solution containing Lu and Yb; and eluting the apparatus to chromatographically separate the Lu and the Yb in order to produce high-specific-activity .sup.177 Yb.

  2. Analysis of175Lu NMR data on dilute alloys of Lu in Tb and Dy

    NASA Astrophysics Data System (ADS)

    Eagles, D. M.; Lalousis, P.

    1980-04-01

    Results of Sano, Shimizu and Itoh on NMR frequencies of175Lu in ferromagnetic Lu0.02Tb0.98 and Lu0.02Dy0.98 alloys are fitted by use of a model with five adjustable parameters. Two of these are related to the magnitude and asymmetry of the electric-field-gradient (EFG) tensor at a Lu nucleus, and three others specify the magnitude of the magnetic hyperfine field and its orientation with respect to the principal axes of the EFG tensor. For Lu Dy it is found that (i) the hyperfine field is tilted with respect to these axes, and (ii) the asymmetry of the EFG tensor differs in magnitude from published calculated values based on a point-change model. For Lu Tb at least one of these two statements is shown to be true. Tilting of the hyperfine field is consistent with inferences from neutron scattering data that the 4f moment is tipped away from the b axis in Tb metal.

  3. A Stability Analysis of Incomplete LU Factorizations.

    DTIC Science & Technology

    1985-02-01

    AD-R52 058 A STABILITY ANALYSIS OF INCOMPLETE LU FRCTORIZRTIONS 1/1 (U) YALE UNIY NEN HRVEN CT DEPT OF COMPUTER SCIENCE H C ELMAN FEB 85 YALEU/DCS/RR... computations involving the triangular factors. Our analysis is similar to stability analysis for methods for ordinary differential equations [10]. It shows...of Goteborg, 1978. Also available as Technical Report 77.04R. 32 [13] Peter Henrici , Elements of Numerical Analysis , John Wiley& Sons, New York, 1964

  4. The Wobbling Mode in ^167Lu

    NASA Astrophysics Data System (ADS)

    Hanan, Amro; Ma, W. C.; Winger, J. A.; Li, Y.; Thompson, J.; Hagemann, G.; Herskind, B.; Sletten, G.; Wilson, J. N.; Jensen, D. R.; Fallon, P.; Ward, D.; Diamond, R. M.; Görgen, A.; Machiavelli, A.; Hübel, H.; Domscheit, J.; Wiedenhöwer, I.

    2002-10-01

    Here we report on the experimental evidence for the wobbling mode in ^167Lu. High spin states in ^167Lu were populated through the ^123Sb(^48Ca,4n) reaction at 203 MeV from the 88 inch Cyclotron at LBNL. Five TSD bands were found in ^167Lu. The two strongest populated, TSD1 and TSD3, bands have been firmly linked to normal deformed (ND) structures. Several transitions connecting TSD2 to TSD1 were identified. From angular distribution and angular correlation analysis, spins and parities for TSD1, TSD2, and TSD3 have been determined. In addition, the mixing and branching ratios for the linking transiti on where experimentally determined to extract the B(E2)_out/B(E2)_in were obtained. These values are much larger than those expected from the signature partner. Furthermore, no three-quasiparticle excitation of the correct spin and parity is expected with similar excitation energies for TSD2 from cranking calculations. This work is supported by US DOE grants DE-FG02-95ER40939 (MSU) and DE-FG02-91ER-40609 (Yale) , the Danish Science Foundation and the German BMBF (contract No. 06 BN 907).

  5. A new polymorph of Lu(PO(3))(3).

    PubMed

    Bejaoui, Anis; Horchani-Naifer, Karima; Férid, Mokhtar

    2008-07-19

    A new polymorph of lutetium polyphosphate, Lu(PO(3))(3), was found to be isotypic with the trigonal form of Yb(PO(3))(3). Two of the three Lu atoms occupy special positions (Wyckoff positions 3a and 3b, site symmetry ). The atomic arrangement consists of infinite helical polyphosphate chains running along the c axis, with a repeat period of 12 PO(4) tetra-hedra, joined with LuO(6) octa-hedra.

  6. Chen-Ning Yang and my Student Days at Stony Brook

    NASA Astrophysics Data System (ADS)

    Chao, Alex

    2008-12-01

    The time was 35 years ago. Chen-Ning Yang, my Ph.D. advisor at Stony Brook, thoughtfully led me through a career decision path that I followed, and have enjoyed since then. This is my reminiscence of that time so critical to my career.

  7. Ionic liquid-based hydrothermal synthesis of Lu2O3 and Lu2O3:Eu3+ microcrysals

    NASA Astrophysics Data System (ADS)

    Li, Yinyan; Xu, Shiqing

    2016-09-01

    Uniform and well-defined Lu2O3 and Lu2O3:Eu3+ microarchitectures have been successfully synthesized via a green and facile ionic liquid-based hydrothermal method followed by a subsequent calcination process. Novel 3D micro-rodbundles and 1D microrods of Lu2O3 and Lu2O3:Eu3+ were controllably obtained through this method. X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy and photoluminescence spectra were used to characterize the micromaterials. The proposed formation mechanisms have been investigated on the basis of a series of SEM studies of the products obtained at different hydrothermal durations. The results indicated that hydrothermal temperature and the ionic liquid-tetrabutylammonium hydroxide were two key factors for the formation as well as the morphology control of the Lu2O3 and Lu2O3:Eu3+ microarchitectures.

  8. [Analysis on the ancient clinical application of Taiyuan (LU 9)].

    PubMed

    Mao, Gai; Jia, Hongling; Zhang, Yongchen

    2015-10-01

    The ancient literature on Taiyuan (LU 9) was collected to summarize the application laws of this acupoint. One thousand TCM ancient works collected in Chinese Medical Dictionary (fourth edition) were retrieved. The literature on the indications of Taiyuan (LU 9), the indications of Taiyuan (LU 9) combined prescriptions, the laws of acupoints combination and the techniques of acupuncture and moxibustion was collected systematically and the database was set up. It is found that there are 333 provisions in compliance with the inclusive standard of Taiyuan (LU 9), 306 provisions for the treatment of disorders and 66 relevant ancient works. There are 119 provisions relevant with the indication of single Taiyuan (LU 9) , 187 provisions for the applications of the combined prescriptions and 143 acupoints for the combined acupoints. Taiyuan (LU 9) and the combined prescriptions are applied to every department in clinic, especially for the disorders of TCM internal medicine department. The combined acupoints are distributed among the fourteen meridians and extra points and had been used totally for 1142 times. Of these points, there are 9 acupoints from the lung meridian of hand-taiyin and 25 acupoints from the bladder meridian of foot-taiyang, with the highest use frequency, 195 times and 141 times respectively, accounting for 17.08% and 12.35% of the total frequency. The common pairs of combination are Taiyuan (LU 9) and Yuji (LU 10), Taiyuan (LU 9) and Lieque (LU 7) and Taiyuan (LU 9) and Taibai (SP 3). The common dose of moxibustion at the acupoint is 3 cones. The depth of insertion is 0.2 cun and the acupuncture time is two breathes.

  9. Measurement of reaction kinetics of [(177)Lu]Lu-DOTA-TATE using a microfluidic system.

    PubMed

    Liu, Z; Schaap, K S; Ballemans, L; de Zanger, R; de Blois, E; Rohde, M; Oehlke, E

    2017-09-12

    Microfluidic synthesis techniques can offer improvement over batch syntheses which are currently used for radiopharmaceutical production. These improvements are, for example, better mixing of reactants, more efficient energy transfer, less radiolysis, faster reaction optimization, and overall improved reaction control. However, scale-up challenges hinder the routine clinical use, so the main advantage is currently the ability to optimize reactions rapidly and with low reactant consumption. Translating those results to clinical systems could be done based on calculations, if kinetic constants and diffusion coefficients were known. This study describes a microfluidic system with which it was possible to determine the kinetic association rate constants for the formation of [(177)Lu]Lu-DOTA-TATE under conditions currently used for clinical production. The kinetic rate constants showed a temperature dependence that followed the Arrhenius equation, allowing the determination of Arrhenius parameters for a Lu-DOTA conjugate (A = 1.24 ± 0.05 × 10(19) M(-1) s(-1), EA = 109.5 ± 0.1 × 10(3) J mol(-1)) for the first time. The required reaction time for the formation of [(177)Lu]Lu-DOTA-TATE (99% yield) at 80 °C was 44 s in a microfluidic channel (100 μm). Simulations done with COMSOL Multiphysics® indicated that processing clinical amounts (3 mL reaction solution) in less than 12 min is possible in a micro- or milli-fluidic system, if the diameter of the reaction channel is increased to over 500 μm. These results show that a continuous, microfluidic system can become a viable alternative to the conventional, batch-wise radiolabelling technique.

  10. Phase separation in LuFeO{sub 3} films

    SciTech Connect

    Cao, Shi E-mail: caoshi86@gmail.com; Sinha, Kishan; Dowben, Peter A.; Xu, Xiaoshan E-mail: caoshi86@gmail.com; Zhang, Xiaozhe; Wang, Wenbin; Wang, Jian

    2016-05-16

    The structural transition at about 1000 °C, from the hexagonal to the orthorhombic phase of LuFeO{sub 3}, has been investigated in thin films of LuFeO{sub 3}. Separation of the two structural phases of LuFeO{sub 3} occurs on a length scale of micrometer, as visualized in real space using X-ray photoemission electron microscopy. The results are consistent with X-ray diffraction and atomic force microscopy obtained from LuFeO{sub 3} thin films undergoing the irreversible structural transition from the hexagonal to the orthorhombic phase of LuFeO{sub 3}, at elevated temperatures. The sharp phase boundaries between the structural phases are observed to align with the crystal planes of the hexagonal LuFeO{sub 3} phase. The coexistence of different structural domains indicates that the irreversible structural transition, from the hexagonal to the orthorhombic phase in LuFeO{sub 3}, is a first order transition, for epitaxial hexagonal LuFeO{sub 3} films grown on Al{sub 2}O{sub 3}.

  11. Neutron Capture Reactions on lu Isotopes at Dance

    NASA Astrophysics Data System (ADS)

    Roig, O.; Meot, V.; Daugas, J.-M.; Morel, P.; Jandel, M.; Vieira, D. J.; Bond, E. M.; Bredeweg, T. A.; Couture, A. J.; Haight, R. C.; Keksis, A. L.; Rundberg, R. S.; Ullmann, J. L.; Wouters, J. M.

    2013-03-01

    The DANCE1 (Detector for Advanced Neutron Capture Experiments) array at LANSCE spallation neutron source in Los Alamos has been used to obtain the neutron radiative capture cross sections for 175Lu and 176Lu with neutron energies from thermal up to 100 keV. Both isotopes are of current interest for the nucleosynthesis s-process.2,3 Three targets were used to perform these measurements. One was natural Lu foil of 31 mg/cm2 and the other two were isotope-enriched targets of 175Lu and 176Lu. Firstly, the cross sections were obtained by normalizing yield to a well-known cross section at the thermal neutron energy. Now, we want to obtain absolute cross sections of radiative capture through a precise neutron flux determination, an accurate target mass measurement and an efficiency determination of the DANCE array.

  12. Growth and characterization of LuAs films and nanostructures

    SciTech Connect

    Krivoy, E. M.; Nair, H. P.; Crook, A. M.; Rahimi, S.; Maddox, S. J.; Salas, R.; Ferrer, D. A.; Dasika, V. D.; Akinwande, D.; Bank, S. R.

    2012-10-01

    We report the growth and characterization of nearly lattice-matched LuAs/GaAs heterostructures. Electrical conductivity, optical transmission, and reflectivity measurements of epitaxial LuAs films indicate that LuAs is semimetallic, with a room-temperature resistivity of 90 {mu}{Omega} cm. Cross-sectional transmission electron microscopy confirms that LuAs nucleates as self-assembled nanoparticles, which can be overgrown with high-quality GaAs. The growth and material properties are very similar to those of the more established ErAs/GaAs system; however, we observe important differences in the magnitude and wavelength of the peak optical transparency, making LuAs superior for certain device applications, particularly for thick epitaxially embedded Ohmic contacts that are transparent in the near-IR telecommunications window around 1.3 {mu}m.

  13. /sup 176/Lu: Cosmic clock or stellar thermometer

    SciTech Connect

    Beer, H.; Kaeppeler, F.; Wisshak, K.; Ward, R.A.

    1981-08-01

    We quantitatively examine the various experimental and theoretical aspects of the stellar synthesis of the long-lived ground state of /sup 176/LU (3.6 x 10/sup 10/ yr). We discuss the various regimes of stellar temperature and free-neutron density in which either (i) the internal electromagnetic couplings between /sup 176/Lu/sup o/ and /sup 176/Lu/sup m/ (3.68 hr) are sufficiently low that they may be treated as separate nuclei, or (ii) the internal couplings are rapidly able to establish thermal equilibrium between /sup 176/Lu/sup o/ and /sup 176/Lu/sup m/. Case (i) above allows /sup 176/Lu/sup o/ to be used as a cosmic clock of galactic s-process nucleosynthesis. As experimental input to the cosmic clock, we have measured the 30 keV neutron capture cross sections: sigma(/sup 170/Yb) = 766 +- 30 mb and sigma(/sup 175/Lu) = 1266 +- 43 mb. This latter value also yields the branching ratio, B, to /sup 176/Lu/sup o/ from neutron capture on /sup 175/Lu as B(24 keV) = 0.362 +- 0.038. Using abundance and cross-section systematics, we derive an upper limit on the mean s-process age of solar material of 11 x 10/sup 9/ yr before the solidification of the meteorites. By requiring the solar abundance of /sup 170/Yb to be consistent with these same sigmaN systematics, we can also bracket the allowable range for the average s-process neutron density as 10/sup 7/ cm/sup -3/< or approx. =< or approx. =4 x 10/sup 7/ cm)/sup 3/. However, for sufficiently high stellar temperatures, case (ii) above implies that the total effective half-life of /sup 176/Lu against beta decay becomes a very strong function of the stellar temperature: t/sub 1/2/(/sup 176/Lu) = 18.5 exp (14.7/T/sub 8/) hr for T/sub 8/>1, and thus the /sup 176/Lu ..-->.. /sup 176/Hf decay would constitute a sensitive stellar s-process thermometer. We show that the fact that /sup 176/Lu does exist in the solar system can place firm constraints on the temperature and neutron density of current models for the site of the

  14. [Analysis of algal blooms in Da-Ning River of Three Gorges Reservoir].

    PubMed

    Zheng, Bing-Hui; Cao, Cheng-Jin; Zhang, Jia-Lei; Huang, Min-Sheng; Chen, Zhen-Lou

    2009-11-01

    According to the survey conducted from Apr. to Jun. 2007 and from Apr. to May. 2008, the changes of water quality, forms and distributions of nutrient salts and characters of algal blooms in Da-ning River of Three Gorges Reservoir (TGR) were studied. The results indicated that the concentrations of nitrogen and phosphorus nutrient were abundant during sensitive period of algal blooms in Da-ning River. Total nitrogen (TN) and total phosphorus (TP) values are 0.84-3.21 mg/L and 0.011-0.531 mg/L respectively, and the nutrients concentrations become high gradually from upstream to downstream. Total dissolved nitrogen (TDN) is the major form of TN accounting for 84%, and total dissolved phosphorus (TDP) is dominant (TDP/TP = 60%). Algal blooms bring phosphorus nutrient bio-concentration. The rates of TN and TP are all in excess of 16, which show eutrophication is limited by phosphorus. Potassium permanganate index and dissolved oxygen (DO) are at low levels and change stably. But chlorophyll a (Chl-a) becomes frequently, the value is 1.41-219.04 mg x m(-3). Significant positive correlations are all observed by correlation analysis between Chl-a and the main parameters (r(Chla-TP) = 0.453, r(Chla-potassium permanganate index) = 0.641, r(Chla-DO) = 0.584, r(Chla-pH) = 0.409, p < 0.01), but significant negative correlations are observed between Chl-a and Secchi depth (SD) (r(Chla-SD) = - 0.392, p < 0.01). The pH is fluctuated by multiparameter esp. in algal blooms. Widespread algae are observed by microscope during sensitive period of algal blooms in Da-ning River accounting for 8 phylum 82 genus 124 species, which Bacillariophyta and Chlorophyta are dominant, and then Cyanophyta and Pyrrophyta. Three whole watershed algal blooms break out in Da-ning River during the period, and the highest values of algal density are 14-1 427 times as many as the normal values. The dominant species of algal blooms are mostly involved with O. borgei, C. microporum, Chlorococcum humicola, P

  15. LUPOD: Collocation in POD via LU decomposition

    NASA Astrophysics Data System (ADS)

    Rapún, M.-L.; Terragni, F.; Vega, J. M.

    2017-04-01

    A collocation method is developed for the (truncated) POD of a set of snapshots. In other words, POD computations are performed using only a set of collocation points, whose number is comparable to the number of retained modes, in a similar fashion as in collocation spectral methods. Intending to rely on simple ideas which, moreover, are consistent with the essence of POD, collocation points are computed via the LU decomposition with pivoting of the snapshot matrix. The new method is illustrated in simple applications in which POD is used as a data-processing method. The performance of the method is tested in the computationally efficient construction of reduced order models based on POD plus Galerkin projection for the complex Ginzburg-Landau equation in one and two space dimensions.

  16. Ternary compounds and isothermal section in Lu-Fe-Ga ternary system at 773 K

    NASA Astrophysics Data System (ADS)

    Liu, Fusheng; Ao, Weiqin; Pan, Laicai; Wang, Qibao; Yan, Jialing; Li, Junqin

    2013-06-01

    The isothermal section of the Lu-Fe-Ga ternary system at 773 K was investigated and constructed based on X-ray powder diffraction analysis. Thirteen binary compounds, Lu2Fe17, Lu6Fe23, LuFe2, LuGa3, LuGa2, Lu3Ga5, LuGa, Lu3Ga2, Lu5Ga3, Fe3Ga, Fe6Ga5, Fe3Ga4, FeGa3, nine ternary solid solutions, T1-LuFe2-1.43Ga0-0.57, T2-LuFe1.34-0.92Ga0.68-1.08, T3-LuFe0.52-0.26Ga1.48-1.74, T5-LuFe2.04-1.72Ga0.96-1.28, T6-Lu6Fe23-21.4Ga0-1.6, T7-Lu2Fe17-14.5Ga0-3.5, T8-Lu2Fe12.9-8.1Ga4.1-8.9, T9-LuFe6.8-5.5Ga5.2-6.5, T10-LuFe5.2-4.5Ga6.8-7.5, and two ternary compounds, T4-LuFe2.35Ga0.65 and T11-Lu2FeGa8 have been confirmed. The structures of the five new ternary compounds or solid solution T2, T3, T4, T5 and T8 are determined by Rietveld refinement method.

  17. Dense LU Factorization on Multicore Supercomputer Nodes

    SciTech Connect

    Lifflander, Jonathan; Miller, Phil; Venkataraman, Ramprasad; Arya, Anshu; Jones, Terry R; Kale, Laxmikant V

    2012-01-01

    Dense LU factorization is a prominent benchmark used to rank the performance of supercomputers. Many implementations, including the reference code HPL, use block-cyclic distributions of matrix blocks onto a two-dimensional process grid. The process grid dimensions drive a trade-off between communication and computation and are architecture- and implementation-sensitive. We show how the critical panel factorization steps can be made less communication-bound by overlapping asynchronous collectives for pivot identification and exchange with the computation of rank-k updates. By shifting this trade-off, a modified block-cyclic distribution can beneficially exploit more available parallelism on the critical path, and reduce panel factorization's memory hierarchy contention on now-ubiquitous multi-core architectures. The missed parallelism in traditional block-cyclic distributions arises because active panel factorization, triangular solves, and subsequent broadcasts are spread over single process columns or rows (respectively) of the process grid. Increasing one dimension of the process grid decreases the number of distinct processes in the other dimension. To increase parallelism in both dimensions, periodic 'rotation' is applied to the process grid to recover the row-parallelism lost by a tall process grid. During active panel factorization, rank-1 updates stream through memory with minimal reuse. In a column-major process grid, the performance of this access pattern degrades as too many streaming processors contend for access to memory. A block-cyclic mapping in the more popular row-major order does not encounter this problem, but consequently sacrifices node and network locality in the critical pivoting steps. We introduce 'striding' to vary between the two extremes of row- and column-major process grids. As a test-bed for further mapping experiments, we describe a dense LU implementation that allows a block distribution to be defined as a general function of block

  18. Quasi four-level Tm:LuAG laser

    NASA Technical Reports Server (NTRS)

    Jani, Mahendra G. (Inventor); Barnes, Norman P. (Inventor); Hutcheson, Ralph L. (Inventor); Rodriguez, Waldo J. (Inventor)

    1997-01-01

    A quasi four-level solid-state laser is provided. A laser crystal is disposed in a laser cavity. The laser crystal has a LuAG-based host material doped to a final concentration between about 2% and about 7% thulium (Tm) ions. For the more heavily doped final concentrations, the LuAG-based host material is a LuAG seed crystal doped with a small concentration of Tm ions. Laser diode arrays are disposed transversely to the laser crystal for energizing the Tm ions.

  19. A new polymorph of Lu(PO3)3

    PubMed Central

    Bejaoui, Anis; Horchani-Naifer, Karima; Férid, Mokhtar

    2008-01-01

    A new polymorph of lutetium polyphosphate, Lu(PO3)3, was found to be isotypic with the trigonal form of Yb(PO3)3. Two of the three Lu atoms occupy special positions (Wyckoff positions 3a and 3b, site symmetry ). The atomic arrangement consists of infinite helical polyphosphate chains running along the c axis, with a repeat period of 12 PO4 tetra­hedra, joined with LuO6 octa­hedra. PMID:21202991

  20. Lu plays music with a keyboard in the Destiny module

    NASA Image and Video Library

    2003-10-26

    ISS007-E-18033 (26 October 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, plays a musical keyboard during off-shift time in the Destiny laboratory on the International Space Station (ISS).

  1. Expedition Seven Lu eating in Zvezda Service module

    NASA Image and Video Library

    2003-09-01

    ISS007-E-14284 (1 September 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, is pictured near food items floating freely in the Zvezda Service Module on the International Space Station (ISS).

  2. Expedition Seven Science Officer Lu slices tomatoes in Zvezda module

    NASA Image and Video Library

    2003-06-21

    ISS007-E-07829 (21 June 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, prepares to eat a meal in the Zvezda Service Module on the International Space Station (ISS).

  3. Complete genome sequence of the giant Pseudomonas phage Lu11.

    PubMed

    Adriaenssens, E M; Mattheus, W; Cornelissen, A; Shaburova, O; Krylov, V N; Kropinski, A M; Lavigne, R

    2012-06-01

    The complete genome sequence of the giant Pseudomonas phage Lu11 was determined, comparing 454 and Sanger sequencing. The double-stranded DNA (dsDNA) genome is 280,538 bp long and encodes 391 open reading frames (ORFs) and no tRNAs. The closest relative is Ralstonia phage ϕRSL1, encoding 40 similar proteins. As such, Lu11 can be considered phylogenetically unique within the Myoviridae and indicates the diversity of the giant phages within this family.

  4. Spectroscopic and lasing properties of Ho:Tm:LuAG

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.; Filer, Elizabeth D.; Naranjo, Felipe L.; Rodriguez, Waldo J.; Kokta, Milan R.

    1993-01-01

    Ho:Tm:LuAG has been grown, examined spectroscopically, and lased at 2.1 microns. Ho:Tm:LuAG was selected for this experimental investigation when quantum-mechanical modeling predicted that it would be a good laser material for Ho laser operation on one of the 5I7 to 5I8 transitions. Lasing was achieved at 2.100 microns, one of the three wavelengths predicted to be most probable for laser action.

  5. Tidal triggering of earthquakes in the Ning'er area of Yunnan Province, China

    NASA Astrophysics Data System (ADS)

    Xie, Chaodi; Lei, Xinglin; Zhao, Xiaoyan; Ma, Qingbo; Yang, Simeng; Wang, Yingnan

    2017-05-01

    To investigate the potential effect of tidal modulation on the seismicity in the Ning'er area, a seismically and geothermally active zone in Yunnan Province, China, we studied the correlation between Earth tides and the occurrence of M ≥ 6.0 earthquakes dating back to 1970, as well as their aftershock sequences, using theoretically calculated tidal stresses and a statistical test. The results show a significant correlation between Earth tides and the occurrence of earthquakes. Six of seven main events occurred when the Earth tide increased the Coulomb failure stress on the source fault. Four main events occurred in a narrow range of phase angle corresponding to the maximum loading rate of tidal stress. Furthermore, the histories of the aftershock sequence as a function of the tidal phases demonstrate clear tidal modulation with a high significance. Thus, we conclude that Earth tides have a clear role in triggering (or modulating) the rupture of the fault systems in the Ning'er area.

  6. An Implicit LU/AF FDTD Method

    NASA Technical Reports Server (NTRS)

    Beggs, John H.; Briley, W. Roger

    2001-01-01

    There has been some recent work to develop two and three-dimensional alternating direction implicit (ADI) FDTD schemes. These ADI schemes are based upon the original ADI concept developed by Peaceman and Rachford and Douglas and Gunn, which is a popular solution method in Computational Fluid Dynamics (CFD). These ADI schemes work well and they require solution of a tridiagonal system of equations. A new approach proposed in this paper applies a LU/AF approximate factorization technique from CFD to Maxwell s equations in flux conservative form for one space dimension. The result is a scheme that will retain its unconditional stability in three space dimensions, but does not require the solution of tridiagonal systems. The theory for this new algorithm is outlined in a one-dimensional context for clarity. An extension to two and threedimensional cases is discussed. Results of Fourier analysis are discussed for both stability and dispersion/damping properties of the algorithm. Results are presented for a one-dimensional model problem, and the explicit FDTD algorithm is chosen as a convenient reference for comparison.

  7. The covalent bonding interaction in the ferroelectric LuMnO3

    NASA Astrophysics Data System (ADS)

    Ahn, Suk-Jin; Kim, Jinyoung; Shin, Namsoo; Koo, Yang-Mo

    2011-10-01

    The electron density distributions of paraelectric and ferroelectric LuMnO3 are analyzed using high temperature synchrotron x-ray powder diffraction data with the Rietveld method, the maximum entropy method (MEM), and MEM-based pattern fitting. Bonding electrons due to orbital hybridization are clearly seen in the Lu1-O3 and Lu2-O4 bonds along the c-axis polarization direction. The Lu1-O3 bond was determined to be covalent due to hybridization below the ferroelectric transition temperature, and was identified as the driving force for ferroelectricity in LuMnO3. However, the Lu2-O4 bond shows covalent character in both paraelectric and ferroelectric states. Also, we suggest that the Lu2-O4 covalent bonding is responsible for large spontaneous polarization in LuMnO3, associated with the small radius of the Lu3+ ion.

  8. Adhesive activity of Lu glycoproteins is regulated by interaction with spectrin

    SciTech Connect

    An, Xiuli; Gauthier, Emilie; Zhang, Xihui; Guo, Xinhua; Anstee, David; Mohandas, Narla; Anne Chasis, Joel

    2008-03-18

    The Lutheran (Lu) and Lu(v13) blood group glycoproteins function as receptors for extracellular matrix laminins. Lu and Lu(v13) are linked to the erythrocyte cytoskeleton through a direct interaction with spectrin. However, neither the molecular basis of the interaction nor its functional consequences have previously been delineated. In the present study, we defined the binding motifs of Lu and Lu(v13) on spectrin and identified a functional role for this interaction. We found that the cytoplasmic domains of both Lu and Lu(v13) bound to repeat 4 of the spectrin chain. The interaction of full-length spectrin dimer to Lu and Lu(v13) was inhibited by repeat 4 of {alpha}-spectrin. Further, resealing of this repeat peptide into erythrocytes led to weakened Lu-cytoskeleton interaction as demonstrated by increased detergent extractability of Lu. Importantly, disruption of the Lu-spectrin linkage was accompanied by enhanced cell adhesion to laminin. We conclude that the interaction of the Lu cytoplasmic tail with the cytoskeleton regulates its adhesive receptor function.

  9. Absorbed dose assessment of 177Lu-zoledronate and 177Lu-EDTMP for human based on biodistribution data in rats

    PubMed Central

    Yousefnia, Hassan; Zolghadri, Samaneh; Jalilian, Amir Reza

    2015-01-01

    Over the past few decades, several bone-seeking radiopharmaceuticals including various bisphosphonate ligands and β-emitting radionuclides have been developed for bone pain palliation. Recently, 177Lu was successfully labeled with zoledronic acid (177Lu-ZLD) as a new generation potential bisphosphonate and demonstrated significant accumulation in bone tissue. In this work, the absorbed dose to each organ of human for 177Lu-ZLD and 177Lu-ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP;as the only clinically bone pain palliation agent) was investigated based on biodistribution data in rats by medical internal radiation dosimetry (MIRD) method. 177Lu-ZLD and 177Lu-EDTMP were prepared in high radiochemical purity (>99%, instant thin layer chromatography (ITLC)) at the optimized condition. The biodistribution of the complexes demonstrated fast blood clearance and major accumulation in the bone tissue. The highest absorbed dose for both 177Lu-ZLD and 177Lu-EDTMP is observed in trabecular bone surface with 12.173 and 10.019 mSv/MBq, respectively. The results showed that 177Lu-ZLD has better characteristics compared to 177Lu-EDTMP and can be a good candidate for bone pain palliation. PMID:26170557

  10. UPSILoN: AUtomated Classification of Periodic Variable Stars using MachIne LearNing

    NASA Astrophysics Data System (ADS)

    Kim, Dae-Won; Bailer-Jones, Coryn A. L.

    2015-12-01

    UPSILoN (AUtomated Classification of Periodic Variable Stars using MachIne LearNing) classifies periodic variable stars such as Delta Scuti stars, RR Lyraes, Cepheids, Type II Cepheids, eclipsing binaries, and long-period variables (i.e. superclasses), and their subclasses (e.g. RR Lyrae ab, c, d, and e types) using well-sampled light curves from any astronomical time-series surveys in optical bands regardless of their survey-specific characteristics such as color, magnitude, and sampling rate. UPSILoN consists of two parts, one which extracts variability features from a light curve, and another which classifies a light curve, and returns extracted features, a predicted class, and a class probability. In principle, UPSILoN can classify any light curves having arbitrary number of data points, but using light curves with more than ~80 data points provides the best classification quality.

  11. Traditional applications and novel approaches in Lu-Hf geochronology

    NASA Astrophysics Data System (ADS)

    Herwartz, D.; Nagel, T. J.; Sandmann, S.; Vitale Brovarone, A.; Rexroth, S.; Rojas-Agramonte, Y.; Froitzheim, N.; Kröner, A.; Skublov, S. G.; Münker, C.

    2012-04-01

    Lutetium-Hf geochronology is currently becoming a routine method for dating metamorphism of garnet bearing rocks, such as eclogites. Prograde garnet growth ages are mostly preserved because blocking temperatures exceed 630 °C [1] and prograde Lu zoning patterns have even been observed in samples that were exposed to temperatures above 800 °C [2]. Here we discuss Lu-Hf ages from various eclogite localities, such as the Northern Tianshan, Kyrgyzstan (~ 470 Ma), the Kola Peninsula, Russia (~ 1900 Ma) [3], Cuba (~70 Ma and ~124 Ma), Alpine Corsica (~ 34 Ma) and the Tauern Window (~32.7 Ma). Age precisions are in the order of 0.1 to 1 % and all ages can be safely attributed to the timing of garnet growth. Some samples, however, contain two garnet populations which complicates Lu-Hf geochronology. In the Adula Nappe (Central Alps) relict garnet has survived a second orogenic cycle, including subduction to mantle depth. By carefully separating the two garnet populations present within the same eclogite sample we obtained a minimum Variscan age of 333 Ma and a maximum Alpine age of 38 Ma [4]. A similar relationship is now evident in samples from the Tauern Window (Eastern Alps), where only one population of garnet generation is visible macroscopically. However, few relics of Variscan garnet inside Alpine garnet are observed in electron microprobe element maps and are also evident from isotopic heterogeneity in 176Lu/177Hf vs. 176Hf/177Hf space. Garnet relics stemming from previous metamorphic events are frequently observed in HP units around the world and the Lu-Hf system is a promising tool to resolve the respective growth ages. Apart from garnet, lawsonite Lu-Hf geochronology was recently identified as a new tool to investigate subduction processes [5]. Here we present a lawsonite Lu-Hf isochron 37,6 ± 1.4 Ma (MSWD = 0.30; n =5) from a lawsonite blueschist from Alpine Corsica. The lawsonite slightly predates the timing of garnet growth (~34 Ma) in three eclogite

  12. LU-HF Age and Isotope Systematics of ALH84001

    NASA Technical Reports Server (NTRS)

    Righter, M.; Lapen, T. J.; Brandon, A. D.; Beard, B. L.; Shafer, J. T.; Peslier, A. H.

    2009-01-01

    Allan Hills (ALH) 84001 is an orthopyroxenite that is unique among the Martian meteorites in having the oldest inferred crystallization age (approx..4.5 to 4.0 Gyr) [e.g., 1-6 and references therein 7]. Its ancient origin makes this stone a critical constraint on early history of Mars, in particular the evolution of different planetary crust and mantle reservoirs. However, because there is significant variability in reported crystallization ages, determination of initial isotope compositions is imprecise making assessment of planetary reservoirs difficult. Here we report a new Lu-Hf mineral isochron age, initial Hf-176/Hf-177 isotope composition, and inferred Martian mantle source compositions for ALH84001 that place constraints on longlived source reservoirs for the enriched shergottite suite of Martian meteorites including Shergotty, Zagami, NWA4468, NWA856, RBT04262, LAR06319, and Los Angeles. Sm-Nd isotope analyses are under way for the same mineral aliquots analyzed for Lu-Hf. The Lu-Hf system was utilized because Lu and Hf are both lithophile and refractory and are not easily redistributed during short-lived thermal pulses associated with shock metamorphism. Moreover, chromite has relatively modest Hf concentrations with very low Lu/Hf ratios [9] yielding tight constraints on initial Hf-176/Hf-177 isotope compositions

  13. Radiative neutron capture cross sections on 176Lu at DANCE

    NASA Astrophysics Data System (ADS)

    Roig, O.; Jandel, M.; Méot, V.; Bond, E. M.; Bredeweg, T. A.; Couture, A. J.; Haight, R. C.; Keksis, A. L.; Rundberg, R. S.; Ullmann, J. L.; Vieira, D. J.

    2016-03-01

    The cross section of the neutron capture reaction 176Lu(n ,γ ) has been measured for a wide incident neutron energy range with the Detector for Advanced Neutron Capture Experiments at the Los Alamos Neutron Science Center. The thermal neutron capture cross section was determined to be (1912 ±132 ) b for one of the Lu natural isotopes, 176Lu. The resonance part was measured and compared to the Mughabghab's atlas using the R -matrix code, sammy. At higher neutron energies the measured cross sections are compared to ENDF/B-VII.1, JEFF-3.2, and BRC evaluated nuclear data. The Maxwellian averaged cross sections in a stellar plasma for thermal energies between 5 keV and 100 keV were extracted using these data.

  14. An overview of SuperLU: Algorithms, implementation, and userinterface

    SciTech Connect

    Li, Xiaoye S.

    2003-09-30

    We give an overview of the algorithms, design philosophy,and implementation techniques in the software SuperLU, for solving sparseunsymmetric linear systems. In particular, we highlight the differencesbetween the sequential SuperLU (including its multithreaded extension)and parallel SuperLU_DIST. These include the numerical pivoting strategy,the ordering strategy for preserving sparsity, the ordering in which theupdating tasks are performed, the numerical kernel, and theparallelization strategy. Because of the scalability concern, theparallel code is drastically different from the sequential one. Wedescribe the user interfaces ofthe libraries, and illustrate how to usethe libraries most efficiently depending on some matrix characteristics.Finally, we give some examples of how the solver has been used inlarge-scale scientific applications, and the performance.

  15. Multiparticle configurations of excited states in 155Lu

    NASA Astrophysics Data System (ADS)

    Carroll, R. J.; Hadinia, B.; Qi, C.; Joss, D. T.; Page, R. D.; Uusitalo, J.; Andgren, K.; Cederwall, B.; Darby, I. G.; Eeckhaudt, S.; Grahn, T.; Gray-Jones, C.; Greenlees, P. T.; Jones, P. M.; Julin, R.; Juutinen, S.; Leino, M.; Leppänen, A.-P.; Nyman, M.; Pakarinen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J.; Scholey, C.; Seweryniak, D.; Simpson, J.

    2016-12-01

    Excited states in the neutron-deficient N =84 nuclide 155Lu have been populated by using the 102Pd(58Ni,α p ) reaction. The 155Lu nuclei were separated by using the gas-filled recoil ion transport unit (RITU) separator and implanted into the Si detectors of the gamma recoil electron alpha tagging (GREAT) spectrometer. Prompt γ -ray emissions measured at the target position using the JUROGAM Ge detector array were assigned to 155Lu through correlations with α decays measured in GREAT. Structures feeding the (11 /2-) and (25 /2-)α -decaying states have been revised and extended. Shell-model calculations have been performed and are found to reproduce the excitation energies of several of the low-lying states observed to within an average of 71 keV. In particular, the seniority inversion of the 25 /2- and 27 /2- states is reproduced.

  16. In vivo red cell destruction by anti-Lu6

    SciTech Connect

    Issitt, P.D.; Valinsky, J.E.; Marsh, W.L.; DiNapoli, J.; Gutgsell, N.S. )

    1990-03-01

    An example is presented of an IgG1, anti-Lu6, that reacted by indirect antiglobulin test and was capable of destroying antigen-positive red cells in vivo. Two methods for the measurement of red cell survival, {sup 51}Cr labeling and flow cytometry, gave the same result: 20 percent of the test dose of Lu:6 red cells was destroyed in the first hour after injection and 80 percent in the first 24 hours. The clinical relevance of the antibody was correctly predicted by an in vitro monocyte monolayer assay. The finding that this example of anti-Lu6 was clinically significant should not be taken to mean that all antibodies directed against high-incidence Lutheran and Lutheran system-related antigens will behave similarly. When such antibodies are encountered, in vivo and/or in vitro studies to assess their clinical significance are necessary before rare blood is used for transfusion.

  17. Lu-Hf constraints on the evolution of lunar basalts

    NASA Technical Reports Server (NTRS)

    Fujimaki, H.; Tatsumoto, M.

    1984-01-01

    It is shown that a cumulate-remelting model best explains the recently acquired data on the Lu-Hf systematics of lunar mare basalts. The model is constructed using Lu and Hf concentration data and is strengthened by Hf isotopic evidence of Unruh et al. (1984). It is shown that the similarity in MgO/FeO ratios and Cr2O3 content in high-Ti and low-Ti basalts are not important constraints on lunar basalt petrogenesis. The model demonstrates that even the very low Ti or green glass samples are remelting products of a cumulate formed after at least 80-90 percent of the lunar magma ocean had solidified. In the model, all the mare basalts and green glasses were derived from 100-150 km depth in the lunar mantle. The Lu-Hf systematics of KREEP basalts clearly indicate that they would be the final residual liquid of the lunar magma ocean.

  18. Scintillation properties of LuI 3:Ce

    NASA Astrophysics Data System (ADS)

    Glodo, J.; Shah, K. S.; Klugerman, M.; Wong, P.; Higgins, B.; Dorenbos, P.

    2005-01-01

    Lutetium iodide (LuI3) is a new addition to the family of Ce-doped lanthanide trihalide scintillating materials. Crystals of this material show hexagonal structure with density of 5.6 g/cm3 and have been grown by the Bridgman method. Under X-ray excitation this material exhibits broad, cerium based emission that peaks at 475 and 520 nm. The fastest and major component of scintillation time profile of LuI3:Ce emission decays with a 31 ns time constant. The light yield of LuI3:Ce for thin samples (∼0.2 mm) was estimated to be ∼50,000 photons/MeV.

  19. ^176Lu/^175Lu thermometry for Oklo natural reactors: a new look at old data

    NASA Astrophysics Data System (ADS)

    Gould, Chris; Sharapov, Eduard

    2012-03-01

    Lutetium thermometry has been used to analyze Oklo natural nuclear reactor zones but leads to widely varying and puzzling predictions for the temperatures TO, which in turn impacts Oklo bounds on the time variation of the fine structure constant α. We revisit results for reactor zone RZ10 in light of new astrophysical measurements of the isomer branching ratio B^g in ^175Lu neutron capture at 5 and 25 keV. We recalculate predictions for TO as a function of B^g using realistic models of the Oklo neutron flux. We find TO= 100 ±30 C using a new value of B^g, in contrast to 350 < TO< 500 C using the evaluated value at thermal energy. Lutetium thermometry can be applicable to analyses of Oklo reactor data, but a better measurement of B^g with thermal neutrons is needed to confirm the reliability of temperature predictions.

  20. Fabrication and characterization of spark plasma sintered Ce:LuAG ceramic for scintillation application

    SciTech Connect

    Kumar, S. Arun; Senthilselvan, J.

    2016-05-23

    Rare earth Cerium doped Lutetium Aluminum Garnet (Ce:LuAG) ceramics are widely used as phosphor material in medical imaging and high-energy physics. Due to its technological importance, an attempt has been made to fabricate Ce:LuAG ceramics by using spark plasma sintering (SPS) technique. XRD patterns of SPS sintered Ce:LuAG ceramics reveals a mixed LuAG and CeO{sub 2} (antisite defect) phases. The microstructures of SPS sintered Ce:LuAG ceramics shows limited densification, inappropriate compaction of particles and existence of residual pores, voids between the grain boundaries affects the transparency of Ce:LuAG ceramics. Relative density and hardness of post sintered Ce:LuAG ceramic is also determined. The effect of Ce{sup 3+} doping concentration and sintering temperature on optical luminescence behavior of Ce:LuAG ceramic is presented.

  1. Complexities of Lu-Hf geochronology in convergent orogens

    NASA Astrophysics Data System (ADS)

    Mulcahy, S. R.; Vervoort, J. D.

    2015-12-01

    Subduction, terrane accretion, and arc magmatism leave a complex and sometimes incomplete record of metamorphism and deformation. The range of metamorphic temperatures and assemblages produced throughout the tectonic evolution of a single orogen often requires multiple isotopic systems to date distinct events. Lu-Hf geochronology, notably, has proven successful for dating metamorphism from a variety of bulk compositions spanning temperatures <350-850 C. We review the success of applying Lu-Hf geochronology in combination with other isotopic systems to date metamorphism from range of metamorphic conditions within convergent margins. We then discuss some complexities of Lu-Hf geochronology when dating samples with complicated metamorphic histories. Garnet and lawsonite isochrons often exhibit excess scatter (high MSWD's) that can be attributed to a number of factors: secondary mineral inclusions, prolonged garnet growth durations, disequilibrium at low temperatures, and polyphase metamorphic histories. Samples with high-Hf inclusions in isotopic equilibrium host phases can lead to decreased precision, but still produce meaningful ages. At high temperatures Lu-Hf ages may date peak metamorphism, cooling from peak temperatures, or result in spurious ages because of preferential retention of 176Hf over 176Lu in garnet. Despite these complexities, and perhaps because of them, new aspects of the metamorphic history may be revealed that are not readily recorded by other isotopic systems. Minerals other than garnet and lawsonite, particularly apatite, and perhaps epidote, offer exciting new possibilities for Lu-Hf geochronology. Careful fieldwork, detailed petrology and geochemistry, and collaborative efforts using multiple isotopic systems offer the best approach to solving tectonic problems in convergent orogens.

  2. Growth and characterization of LuVO4 single crystals

    NASA Astrophysics Data System (ADS)

    Dimitrov, D. Z.; Rafailov, P. M.; Chen, Y. F.; Lee, C. S.; Todorov, R.; Juang, J. Y.

    2017-09-01

    Large LuVO4 single crystals have been successfully obtained by high-temperature solution method. The structure details of these crystals are determined by X-ray crystallographic analysis and Raman spectroscopy. It is observed that the crystal consists of LuVO4 phase with trace amount of imperfections possibly due to oxygen vacancies. The optical quality of the crystal is assessed by Spectroscopic Ellipsometry (SE). The crystal shows higher than +0.2 birefringence in a large interval of wavelengths.

  3. Performance analysis of parallel supernodal sparse LU factorization

    SciTech Connect

    Grigori, Laura; Li, Xiaoye S.

    2004-02-05

    We investigate performance characteristics for the LU factorization of large matrices with various sparsity patterns. We consider supernodal right-looking parallel factorization on a bi-dimensional grid of processors, making use of static pivoting. We develop a performance model and we validate it using the implementation in SuperLU-DIST, the real matrices and the IBM Power3 machine at NERSC. We use this model to obtain performance bounds on parallel computers, to perform scalability analysis and to identify performance bottlenecks. We also discuss the role of load balance and data distribution in this approach.

  4. STS-106 Mission Specialist Lu suits up before launch

    NASA Technical Reports Server (NTRS)

    2000-01-01

    STS-106 Mission Specialist Edward T. Lu smiles as he gets suited up in the Operations and Checkout Building before launch. This is Lu'''s second space flight. Space Shuttle Atlantis is set to lift off 8:45 a.m. EDT on the fourth flight to the International Space Station. During the 11-day mission, the seven-member crew will perform support tasks on orbit, transfer supplies and prepare the living quarters in the newly arrived Zvezda Service Module. The first long-duration crew, dubbed '''Expedition One,''' is due to arrive at the Station in late fall.

  5. Home Education of a Bright Student: A Case Study on Lu Wei

    ERIC Educational Resources Information Center

    Yuexiang, Chen; Hongfang, Zhou

    2006-01-01

    In this article, the authors explore the life history and home education of Lu Wei, a top student in the 2004 Guangdong Province College entrance examination. The authors argue that the following issues of Lu's home education played an important role in Lu's success: emphasis and nurture of intellectual development in the early years of life,…

  6. Bu-Shen-Ning-Xin decoction suppresses osteoclastogenesis via increasing dehydroepiandrosterone to prevent postmenopausal osteoporosis.

    PubMed

    Gui, Yuyan; Qiu, Xuemin; Xu, Yingping; Li, Dajin; Wang, Ling

    2015-06-01

    Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in vitro because of the critical roles of bone resorption in the development and progression of osteoporosis. In mice, serum levels of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and 17-β-estradiol (E2) were evaluated with an enzyme immunoassay kit after ovariectomy. Levels of DHEA and DHEAS increased significantly following administration of BSNXD while the level of E2 did not. In addition, tartrate-resistance acid phosphatase staining showed that DHEA profoundly inhibited RANKL-induced osteoclastogenesis in vitro in a dose-dependent manner via estrogen receptor α (ERα) but not via estrogen receptor β or androgen receptors. Cytotoxicity was not detected in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. These data suggest that BSNXD prevents PMO by increasing DHEA via the ERαpathway to suppress osteoclastogenesis.

  7. Light yield and light loss coefficient of LuAG:Ce and LuAG:Pr under excitation with α- and γ-rays

    NASA Astrophysics Data System (ADS)

    Sreebunpeng, Krittiya; Chewpraditkul, Weerapong; Nikl, Martin

    2017-06-01

    Light yield and light loss coefficient of Lu3Al5O12:Ce (LuAG:Ce) and Lu3Al5O12:Pr (LuAG:Pr) single crystals grown by the Czochralski method were investigated under excitation with α- and γ-rays. Photoelectron yield and energy resolution were measured using the XP5200B photomultiplier. The dependence of photoelectron yield on sample height was measured under excitation with α- and γ-rays and the light loss coefficient was evaluated. It was found that the light loss coefficient of LuAG:Ce is smaller than that of LuAG:Pr. The ratio of photoelectron yield under excitation with α- and γ-rays (α/γ ratio) was also determined and discussed.

  8. Parallel LU-factorization algorithms for dense matrices

    SciTech Connect

    Oppe, T.C.; Kincaid, D.R.

    1987-05-01

    Several serial and parallel algorithms for computing the LU-factorization of a dense matrix are investigated. Numerical experiments and programming considerations to reduce bank conflicts on the Cray X-MP4 parallel computer are presented. Speedup factors are given for the parallel algorithms. 15 refs., 6 tabs.

  9. sup 176 Lu: An unreliable s-process chronometer

    SciTech Connect

    Lesko, K.T.; Norman, E.B.; Larimer, R.M.; Sur, B.

    1990-11-01

    A level scheme of {sup 176}Lu up to {approximately}1400 keV excitation energy is deduced from a gamma-gamma coincidence experiment and previously published particle transfer data. 170 gamma-ray transitions are placed between 85 levels, confirming many of the previously established levels and some of the decay scheme. A level at 835.5 keV (J{sup {pi}} = 5{sup {minus}}, t{sub 1/2} < 10 ns) decays with substantial strength to both the ground state (7{sup {minus}}, 4.08 {times} 10{sup 10} yr) and the 122.9 keV isomer (1{sup {minus}}, 3.7 hr). The presence of this level guarantees the thermal equilibration of {sup 176}Lu{sup g,m} for temperatures greater than 3 {times} 10{sup 8} K and therefore during s-process nucleosynthesis. The resulting extreme temperature sensitivity of its effective half-life rules out the use of {sup 176}Lu as an s-process chronometer. The use of {sup 176}Lu to determine s-process temperatures is discussed. 30 refs., 11 figs., 3 tabs.

  10. Resonantly pumped room temperature Ho:LuVO₄ laser.

    PubMed

    Yao, B Q; Cui, Z; Duan, X M; Du, Y Q; Han, L; Shen, Y J

    2014-11-01

    Spectroscopic characterization of a Ho:LuVO4 crystal grown by the Czochralski method has been performed, including the absorption and emission spectra. We demonstrate a 2 μm room temperature Ho:LuVO4 laser, resonantly pumped by a 1.94 μm Tm:YAP laser. By use of an output coupler with T=10% transmission, the Ho:LuVO4 laser generated continuous-wave output power of 2.5 W at 2074.18 nm, with a beam quality factor of Mx2=My2=1.3, for a total incident pump power of 19.4 W. The slope efficiency with respect to the pump power was 17.6%, and the optical-to-optical efficiency was 12.9%. Moreover, we obtained a Ho:LuVO4 laser that operated at 2073.77 and 2055.27 nm, by using different output couplers with transmissions of T=15 and 30%.

  11. Conductively Cooled Ho:Tm:LuLiF Laser Amplifier

    NASA Technical Reports Server (NTRS)

    Bai, Yingxin; Yu, Jirong; Trieu, Bo; Petros, M.; Petzar, Paul; Lee, Hyung; Singh, U.

    2008-01-01

    A conductively-cooled Ho:Tm:LuLiF laser head can amplify 80mJ/340ns probe pulses into 400mJ when the pump pulse energy is close to amplified spontaneous emission (ASE) threshold, 5.6J. For a small signal, the double-pass amplification exceeds 25.

  12. Lu and Duque play with a droplet of liquid

    NASA Image and Video Library

    2003-10-25

    ISS007-E-18001 (25 October 2003) --- Astronaut Edward T. Lu (with camera), Expedition 7 NASA ISS science officer and flight engineer, and European Space Agency (ESA) astronaut Pedro Duque of Spain observe a bubble of liquid floating freely in the Zvezda Service Module on the International Space Station (ISS).

  13. Lu and Duque in Destiny laboratory with musical keyboard

    NASA Image and Video Library

    2003-10-26

    ISS007-E-18044 (26 October 2003) --- Astronaut Edward T. Lu (at musical keyboard), Expedition 7 NASA ISS science officer and flight engineer, and European Space Agency (ESA) astronaut Pedro Duque of Spain share a light moment during off-shift time in the Destiny laboratory on the International Space Station (ISS).

  14. Effect of reducing Lu3+ content on the fabrication and scintillation properties of non-stoichiometric Lu3-xAl5O12:Ce ceramics

    NASA Astrophysics Data System (ADS)

    Liu, Shuping; Mares, Jiri A.; Babin, Vladimir; Hu, Chen; Kou, Huamin; D'Ambrosio, Carmelo; Pan, Yubai; Nikl, Martin

    2017-01-01

    Lu3-xAl5O12:Ce optical ceramics (Lu3-xAG:Ce, x = 1, 2, 3 and 4 at.%, respectively) with Lu3+ compositions ranging from 1 to 4 at.% below stoichiometry content were fabricated by solid state reaction method and further optimized by an air-annealing process. The effect of Lu3+ deficiency on the optical, luminescence and scintillation properties of such a non-stoichiometric Lu3-xAl5O12:Ce ceramics was investigated. Significant influence in the material densification was found leading to strong changes in the transparency, radioluminescence (RL) and scintillation response of these ceramics. Within the range of 1-4 at.% Lu3+ deficiency, LuAl antisite defects were suppressed effectively and the Lu3-xAG:Ce ceramics displayed an extremely high RL intensity which reaches ∼4 times higher than that of the latest commercial LuAG:Ce single crystals while its transparency deteriorated. The microstructure, presence of foreign phases and charge traps acting in scintillation mechanism were also characterized by means of SEM, back scattered electron imaging and thermoluminescence techniques, respectively.

  15. Biodistribution and Dosimetry of 177Lu-tetulomab, a New Radioimmunoconjugate for Treatment of Non-Hodgkin Lymphoma

    PubMed Central

    Repetto-Llamazares, Ada H V; Larsen, Roy H; Mollatt, Camilla; Lassmann, Michael; Dahle, Jostein

    2013-01-01

    The biodistribution of the anti-CD37 radioimmunoconjugate 177Lu-tetraxetan-tetulomab (177Lu-DOTA-HH1) was evaluated. Biodistribution of 177Lu-tetraxetan-tetulomab was compared with 177Lu-tetraxetan-rituximab and free 177Lu in nude mice implanted with Daudi lymphoma xenografts. The data showed that 177Lu-tetulomab had a relevant stability and tumor targeting properties in the human lymphoma model. The half-life of 177Lu allowed significant tumor to normal tissue ratios to be obtained indicating that 177Lu-tetraxetan-tetulomab could be suitable for clinical testing. The biological and effective half-life in blood was higher for 177Lu-tetraxetan-tetulomab than for 177Lu-tetraxetan-rituximab. The biodistribution of 177Lu-tetraxetan-tetulomab did not change significantly when the protein dose was varied from 0.01 to 1 mg/kg. Dosimetry calculations showed that the absorbed radiation doses to normal tissues and tumor in mice were not significantly different for 177Lu-tetraxetan-tetuloma b and 177Lu-tetraxetan-rituximab. The absorbed radiation doses were extrapolated to human absorbed radiation doses. These extrapolated absorbed radiation doses to normal tissues for 177Lu-tetraxetan-tetulomab at an injection of 40 MBq/kg were significantly lower than the absorbed radiation doses for 15 MBq/kg Zevalin, suggesting that higher tumor radiation dose can be reached with 177Lu-tetraxetan-tetulomab in the clinic. PMID:23256748

  16. Lu-Hf and PbSL geochronology of apatites from Proterozoic terranes: A first look at Lu-Hf isotopic closure in metamorphic apatite

    NASA Astrophysics Data System (ADS)

    Barfod, Gry Hoffmann; Krogstad, Eirik Jens; Frei, Robert; Albarède, Francis

    2005-04-01

    The mineral apatite is characterized by elevated and highly variable Lu/Hf ratios that, in some cases, allow for single-crystal dating by the Lu-Hf isotopic system. Apatites from the Adirondack Lowlands and Otter Lake area in the Grenville Province, and from the Black Hills, South Dakota, yield Lu-Hf ages that are consistently older than their respective Pb step leaching ages. Isotopic closure for the Lu-Hf system, therefore, occurs before U-Pb system closure in this mineral. In the Adirondack Lowlands, where H 2O activity was low, Lu-Hf systematics of cm-sized apatite crystals remained undisturbed during upper amphibolite facies metamorphism (˜700 to 675 °C) at 1170-1130 Ma. The relatively old Lu-Hf ages of 1270 and 1230 Ma observed for these apatites correlate with decreasing crystal size. In contrast, apatite from the fluid-rich Otter Lake area and Black Hills yields unrealistically low apparent Lu-Hf closure temperatures, implying that in these apatites, fluids facilitated late exchange. The Lu-Hf ages for the metamorphic apatites were thus controlled either by the prevailing temperature and grain size, or by fluid activity.

  17. Comparison of LuAP and LuYAP crystal properties from statistically significant batches produced with two different growth methods

    NASA Astrophysics Data System (ADS)

    Trummer, J.; Auffray, E.; Lecoq, P.; Petrosyan, A.; Sempere-Roldan, P.

    2005-10-01

    Measurements of the light yield, decay time and transmission were carried out on LuAP:Ce and mixed LuYAP:Ce crystals, which are new scintillation materials considered for Positron Emission Tomography (PET) and are used in the ClearPET™ [Auffray et al., Nucl. Sci. Methods A 527 (2004) 171 [15

  18. Optimization of irradiation conditions for {sup 177}Lu production at the LVR-15 research reactor

    SciTech Connect

    Lahodova, Z.; Viererbl, L.; Klupak, V.; Srank, J.

    2012-07-01

    The use of lutetium in medicine has been increasing over the last few years. The {sup 177}Lu radionuclide is commercially available for research and test purposes as a diagnostic and radiotherapy agent in the treatment of several malignant tumours. The yield of {sup 177}Lu from the {sup 176}Lu(n,{gamma}){sup 177}Lu nuclear reaction depends significantly on the thermal neutron fluence rate. The capture cross-sections of both reaction {sup 176}Lu(n,{gamma}){sup 177}Lu and reaction {sup 177}Lu(n,{gamma}){sup 178}Lu are very high. Therefore a burn-up of target and product nuclides should be taken into account when calculating {sup 177}Lu activity. The maximum irradiation time, when the activity of the {sup 177}Lu radionuclide begins to decline, was found for different fluence rates. Two vertical irradiation channels at the LVR-15 nuclear research reactor were compared in order to choose the channel with better irradiation conditions, such as a higher thermal neutron fluence rate in the irradiation volume. In this experiment, lutetium was irradiated in a titanium capsule. The influence of the Ti capsule on the neutron spectrum was monitored using activation detectors. The choice of detectors was based on requirements for irradiation time and accurate determination of thermal neutrons. The following activation detectors were selected for measurement of the neutron spectrum: Ti, Fe, Ni, Co, Ag and W. (authors)

  19. The clinical pharmacokinetics of Lu AA21004 and its major metabolite in healthy young volunteers.

    PubMed

    Areberg, Johan; Søgaard, Birgitte; Højer, Astrid-Maria

    2012-09-01

    Lu AA21004 is a novel multimodal antidepressant that is currently in phase 3 development. The objective of this report was to detail the clinical pharmacokinetics of Lu AA21004 and its major but inactive metabolite Lu AA34443 (3-methyl-4-(2-piperazine-1-yl-phenylsulfanyl)-benzoic acid) in healthy men and women aged between 18 and 53 years. Data from two single-dose and one multiple-dose study were combined; the total number of volunteers was 97 (64 men, 33 women). Blood and urine samples were collected after p.o. and i.v. administrations to determine the content of Lu AA21004 and Lu AA34443 performed with a validated method. Standard pharmacokinetic parameters were estimated with non-compartmental analysis. The absolute bioavailability was 75%. After oral administration, Lu AA21004 showed an extended absorption phase, a medium clearance and a large volume of distribution resulting in late t(max) values and a mean elimination half-life of 57 hr. The exposure of Lu AA21004 showed a linear relationship with dose in the dose ranges studied (up to 75-mg single dosing and 60-mg multiple dosing). After weight correction, no differences in exposure for Lu AA21004 and Lu AA34443 were observed between men and women. The renal clearance of Lu AA21004 was negligible. The major metabolite Lu AA34443 had a half-life similar to that of Lu AA21004 but a lower accumulation ratio at steady-state, indicating formation-rate-limited elimination. In conclusion, Lu AA21004 showed an extended absorption phase, a medium clearance and a large volume of distribution. © 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society.

  20. Rotational bands and isomeric states in 175Lu

    SciTech Connect

    Garrett, P E; Archer, D E; Becker, J A; Bernstein, L A; Hauschild, K; Henry, E A; McNabb, D P; Stoyer, M A; Younes, W; Johns, G D; Nelson, R O; Wilburn, W S

    2003-10-15

    Rotational bands in {sup 175}Lu have been extended through investigation with the (n,n{prime}{gamma}) reaction. Spallation neutrons bombarded Lu samples, and the resulting {gamma} rays were detected in a large-scale Compton-suppressed Ge detector array. Prompt- and delayed-{gamma}{gamma} coincidences have been used to extend most of the existing known bands, and to tentatively assign a new band, based on the 7/2{sup -}[523] configuration, from its band head to spin 13/2. The 3-quasiparticle K{sup {pi}} = 19/2{sup +} isomer is confirmed and its half life determined to be 984 {+-} 13(stat.) {+-} 30(sys.) {micro}s, in agreement with previous results.

  1. Biased dielectric response in LuFe2O4

    NASA Astrophysics Data System (ADS)

    Kudasov, Yu. B.; Markelova, M.; Maslov, D. A.; Platonov, V. V.; Surdin, O. M.; Kaul, A.

    2016-12-01

    A complex permittivity at a low level of excitation signal was measured in ceramic LuFe2O4. A Debye-type relaxation response with a strong temperature dependence of a characteristic frequency was observed in accordance with earlier works. A small DC bias of about 10 V/cm led to unusual changes in the dielectric response. At frequencies, which were lower than the characteristic one, the conductivity drastically increased with slight decrease of the real part of the permittivity under the bias. In the opposite case of low frequencies, there are no traces of the DC bias effect. We show that an inhomogeneous charge distribution over surface layer (domain structure) is essential for describing the biased dielectric response in LuFe2O4.

  2. Investigation of nanostructured Lu2O3:Tb

    NASA Astrophysics Data System (ADS)

    Zych, E.; Deren, Przemyslaw J.; Strek, Wieslaw; Meijerink, Andries; Domagala, K.; Mielcarek, W.

    2001-04-01

    Nano structured Lu2O3, both plane and doped with Tb, was prepared utilizing a combustion technique. The best crystallity of the products can be obtained initiating the reaction within 560-700 $DEGC range of temperature. Tb easily enters the nano scaled host lattice both as Tb3+ and Tb4+. The former gives rise to a typical green emission of the ion, while the later introduces a broad-band visible absorption, due to charge transfer transitions. The green emission of Tb3+ from a raw material may be radically increased by after- preparation heat-treatment. Undoped material gives rise to a blue emission, which disappears when Tb content with respect to Lu reaches 0.0001% or higher level.

  3. (177)Lu-PSMA Radioligand Therapy for Prostate Cancer.

    PubMed

    Fendler, Wolfgang P; Rahbar, Kambiz; Herrmann, Ken; Kratochwil, Clemens; Eiber, Matthias

    2017-08-01

    (177)Lu-prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) using inhibitors of PSMA is a novel therapeutic option in patients with metastatic castration-resistant prostate cancer. The current literature suggests that this therapy is well tolerated and effective. On the basis of clinical need and current evidence, the therapy is being implemented in a growing number of centers worldwide. Here, we review important aspects of (177)Lu-PSMA RLT, including patient stratification, the therapy protocol, concomitant medication, and follow-up, to inform medical staff involved in the RLT and care of patients with metastatic castration-resistant prostate cancer. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

  4. Flashlamp-pumped Ho:Tm:Cr:LuAG laser

    NASA Technical Reports Server (NTRS)

    Jani, Mahendra G. (Inventor); Barnes, Norman P. (Inventor); Murray, Keith E. (Inventor); Kokta, Milan R. (Inventor)

    1997-01-01

    A room temperature solid-state laser is provided. A laser crystal is disposed in a laser cavity. The laser crystal has a LuAG host material doped with a concentration of about 0.35% Ho ions, about 5.57% Tm ions and at least about 1.01% Cr ions. A broadband energizing source such as a flashlamp is disposed transversely to the laser crystal to energize the Ho ions, Tm ions and Cr ions.

  5. Shape evolution with angular momentum in Lu isotopes

    NASA Astrophysics Data System (ADS)

    Kardan, Azam; Sayyah, Sepideh

    2016-06-01

    The nuclear potential energies of Lu isotopes with neutron number N = 90 - 98 up to high spins are computed within the framework of the unpaired cranked Nilsson-Strutinsky method. The potential and the macroscopic Lublin-Strasbourg drop (LSD) energy-surface diagrams are analyzed in terms of quadrupole deformation and triaxiality parameter. The shape evolution of these isotopes with respect to angular momentum, as well as the neutron number is studied.

  6. MS Lu conducts electrical work in Zvezda during STS-106

    NASA Image and Video Library

    2000-09-13

    S106-E-5213 (13 September 2000) --- Astronaut Edward T. Lu follows printed guidelines as he assumes the role of an electrician onboard the Zvezda service module on the International Space Station (ISS). Electrical work was the hallmark of the day as four of the mission specialists aboard ISS (temporarily docked with the Space Shuttle Atlantis) replaced batteries inside the Zarya and Zvezda modules while supply transfer continued around them.

  7. Lattice dynamics of LuPO{sub 4}

    SciTech Connect

    Nipko, J.C. |; Loong, C.-K.; Loewenhaupt, M.; Reichardt, W.; Braden, M.; Boatner, L.A.

    1996-06-01

    Lutetium orthophosphate is an important nonmagnetic host material for rare-earth-activated luminescence applications. We have measured the LuPO{sub 4} phonon density of states and dispersion curves along the [{xi}00],[{xi}{xi}0], and [00{xi}] symmetry directions by neutron spectroscopy using polycrystalline and single-crystal samples. A quantitative analysis of the neutron results was carried out using a lattice-dynamical shell model.

  8. MS Lu works in the transfer tunnel during STS-106

    NASA Image and Video Library

    2000-09-17

    S106-E-5281 (17 September 2000) --- Astronaut Edward T. Lu, mission specialist, can literally see the light at the end of the tunnel, as he and six STS-106 crewmates wind down toward the end of their interface with the International Space Station (ISS). The crew soon will be sealing itself off from the station and returning to the crew cabin of Atlantis and Spacehab for the remainder of the 12-day mission.

  9. Encapsulation of a radiolabeled cluster inside a fullerene cage, (177)Lu(x)Lu((3-x))N@C(80): an interleukin-13-conjugated radiolabeled metallofullerene platform.

    PubMed

    Shultz, Michael D; Duchamp, James C; Wilson, John D; Shu, Chun-Ying; Ge, Jiechao; Zhang, Jianyuan; Gibson, Harry W; Fillmore, Helen L; Hirsch, Jerry I; Dorn, Harry C; Fatouros, Panos P

    2010-04-14

    In this communication, we describe the successful encapsulation of (177)Lu into the endohedral metallofullerene (177)Lu(x)Lu(3-x)N@C(80) (x = 1-3) starting with (177)LuCl(3) in a modified quartz Kraschmer-Huffman electric generator. We demonstrate that the (177)Lu (beta-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.

  10. Automatic Blocking Of QR and LU Factorizations for Locality

    SciTech Connect

    Yi, Q; Kennedy, K; You, H; Seymour, K; Dongarra, J

    2004-03-26

    QR and LU factorizations for dense matrices are important linear algebra computations that are widely used in scientific applications. To efficiently perform these computations on modern computers, the factorization algorithms need to be blocked when operating on large matrices to effectively exploit the deep cache hierarchy prevalent in today's computer memory systems. Because both QR (based on Householder transformations) and LU factorization algorithms contain complex loop structures, few compilers can fully automate the blocking of these algorithms. Though linear algebra libraries such as LAPACK provides manually blocked implementations of these algorithms, by automatically generating blocked versions of the computations, more benefit can be gained such as automatic adaptation of different blocking strategies. This paper demonstrates how to apply an aggressive loop transformation technique, dependence hoisting, to produce efficient blockings for both QR and LU with partial pivoting. We present different blocking strategies that can be generated by our optimizer and compare the performance of auto-blocked versions with manually tuned versions in LAPACK, both using reference BLAS, ATLAS BLAS and native BLAS specially tuned for the underlying machine architectures.

  11. An Antibody to the Lutheran Glycoprotein (Lu) Recognizing the LU4 Blood Type Variant Inhibits Cell Adhesion to Laminin α5

    PubMed Central

    Kikkawa, Yamato; Miwa, Takahiro; Tohara, Yukiko; Hamakubo, Takayuki; Nomizu, Motoyoshi

    2011-01-01

    Background The Lutheran blood group glycoprotein (Lu), an Ig superfamily (IgSF) transmembrane receptor, is also known as basal cell adhesion molecule (B-CAM). Lu/B-CAM is a specific receptor for laminin α5, a major component of basement membranes in various tissues. Previous reports have shown that Lu/B-CAM binding to laminin α5 contributes to sickle cell vaso-occlusion. However, as there are no useful tools such as function-blocking antibodies or drugs, it is unclear how epithelial and sickled red blood cells adhere to laminin α5 via Lu/B-CAM. Methodology/Principal Findings In this study, we discovered a function-blocking antibody that inhibits Lu binding to laminin α5 using a unique binding assay on tissue sections. To characterize the function-blocking antibody, we identified the site on Lu/B-CAM recognized by this antibody. The extracellular domain of Lu/B-CAM contains five IgSF domains, D1-D2-D3-D4-D5. The antibody epitope was localized to D2, but not to the D3 domain containing the major part of the laminin α5 binding site. Furthermore, mutagenesis studies showed that Arg175, the LU4 blood group antigenic site, was crucial for forming the epitope and the antibody bound sufficiently close to sterically hinder the interaction with α5. Cell adhesion assay using the antibody also showed that Lu/B-CAM serves as a secondary receptor for the adhesion of carcinoma cells to laminin α5. Conclusion/Significance This function-blocking antibody against Lu/B-CAM should be useful for not only investigating cell adhesion to laminin α5 but also for developing drugs to inhibit sickle cell vaso-occlusion. PMID:21858073

  12. 177Lu-labeled Gold Nanoparticles for Radiation Therapy of Locally Advanced Breast Cancer

    NASA Astrophysics Data System (ADS)

    Yook, Simmyung

    Locally advanced breast cancer (LABC) occurs in about 10-15% of patients diagnosed with breast cancer (BC) and 30% of these patients have triple negative breast cancer (TNBC) that are often epidermal growth factor receptor (EGFR)-positive. The goal of the proposed research was design and evaluate preclinically a novel radiation nanomedicine for LABC composed of EGFR-targeted gold nanoparticles (AuNP) by covalently conjugating panitumumab and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) complexing 177Lu incorporated into a metal-chelating polymer (MCP) (177 Lu-T-AuNP) which could be used as a neoadjuvant treatment to improve the outcome of patients with LABC. 177Lu-T-AuNP were efficiently internalized by EGFR-positive BC cells and were significantly more effective than 177Lu-labeled and non-targeted (NT)-AuNP for killing these cells. For radiation treatment of EGFR-positive tumours, both 177Lu-T-AuNP and 177Lu-NT-AuNP were intratumourally (i.t.) injected into athymic mice with MDA-MB-468 BC xenografts for comparison. Biodistribution studies showed that 177Lu-T-AuNPs exhibited 2-fold higher tumour retention than 177Lu-NT-AuNPs following i.t. injection at 48 h p.i. Both forms of radiolabeled AuNP were highly effective for inhibiting tumour growth without normal organ toxicity due to local tumour retention of both form of AuNP. To minimize the displacement of 177Lu-labeled MCP from AuNP, polyethylene glycol (PEG) ligands presenting a disulfide [ 177Lu-DOTA-PEG-ortho-pyridyl disulfide (OPSS)], a lipoic acid (LA) [177Lu-DOTA-PEG-lipoic acid (LA)] or multi-LA [PEG- pGlu(177Lu-DOTA)8-LA4] for multivalent binding were synthesized and the stability of MCP-AuNP complexes determined. In vitro challenge study with thiol-containing molecules or human plasma, PEG-pGlu(DOTA)8-LA4-AuNP were most stable. In whole body elimination study, elimination of radioactivity due to displacement of 177Lu-MCP from AuNP in mice injected with 177Lu-DOTA-PEG-OPSS-AuNP was more

  13. [On the lecture on the history of anatomy which Lu Xun heard in Sendai].

    PubMed

    Sakai, Tatsuo

    2008-12-01

    In "Fujino Sensei," Lu Xun wrote that in his first lecture on anatomy, osteology Professor Fujino talked about the history of anatomy in Japan; although Lu Xun's extant lecture notes do not show any mention of Fujino's comments on the history of anatomy. However, since the lecture notes of senior students mention the history of anatomy, we do not find any reason to assume that Lu Xun did not hear about the history of anatomy in the lecture. Furthermore, the timetable of lectures indicates that the first lecture of anatomy was attributed to Professor Fujino. It is concluded that the description of the first anatomical lecture in "Fujino Sensei" was written based on Lu Xun's actual experience. The lecture on the history of anatomy which Lu Xun heard was made by Professor Fujino; probably based on a lecture by Professor Shikinami which was recorded in the notes of Saito Ryusho, a student who was three years senior to Lu Xun.

  14. LuIII parvovirus selectively and efficiently targets, replicates in, and kills human glioma cells.

    PubMed

    Paglino, Justin C; Ozduman, Koray; van den Pol, Anthony N

    2012-07-01

    Because productive infection by parvoviruses requires cell division and is enhanced by oncogenic transformation, some parvoviruses may have potential utility in killing cancer cells. To identify the parvovirus(es) with the optimal oncolytic effect against human glioblastomas, we screened 12 parvoviruses at a high multiplicity of infection (MOI). MVMi, MVMc, MVM-G17, tumor virus X (TVX), canine parvovirus (CPV), porcine parvovirus (PPV), rat parvovirus 1A (RPV1A), and H-3 were relatively ineffective. The four viruses with the greatest oncolytic activity, LuIII, H-1, MVMp, and MVM-G52, were tested for the ability, at a low MOI, to progressively infect the culture over time, causing cell death at a rate higher than that of cell proliferation. LuIII alone was effective in all five human glioblastomas tested. H-1 progressively infected only two of five; MVMp and MVM-G52 were ineffective in all five. To investigate the underlying mechanism of LuIII's phenotype, we used recombinant parvoviruses with the LuIII capsid replacing the MVMp capsid or with molecular alteration of the P4 promoter. The LuIII capsid enhanced efficient replication and oncolysis in MO59J gliomas cells; other gliomas tested required the entire LuIII genome to exhibit enhanced infection. LuIII selectively infected glioma cells over normal glial cells in vitro. In mouse models, human glioblastoma xenografts were selectively infected by LuIII when administered intratumorally; LuIII reduced tumor growth by 75%. LuIII also had the capacity to selectively infect subcutaneous or intracranial gliomas after intravenous inoculation. Intravenous or intracranial LuIII caused no adverse effects. Intracranial LuIII caused no infection of mature mouse neurons or glia in vivo but showed a modest infection of developing neurons.

  15. LuIII Parvovirus Selectively and Efficiently Targets, Replicates in, and Kills Human Glioma Cells

    PubMed Central

    Paglino, Justin C.; Ozduman, Koray

    2012-01-01

    Because productive infection by parvoviruses requires cell division and is enhanced by oncogenic transformation, some parvoviruses may have potential utility in killing cancer cells. To identify the parvovirus(es) with the optimal oncolytic effect against human glioblastomas, we screened 12 parvoviruses at a high multiplicity of infection (MOI). MVMi, MVMc, MVM-G17, tumor virus X (TVX), canine parvovirus (CPV), porcine parvovirus (PPV), rat parvovirus 1A (RPV1A), and H-3 were relatively ineffective. The four viruses with the greatest oncolytic activity, LuIII, H-1, MVMp, and MVM-G52, were tested for the ability, at a low MOI, to progressively infect the culture over time, causing cell death at a rate higher than that of cell proliferation. LuIII alone was effective in all five human glioblastomas tested. H-1 progressively infected only two of five; MVMp and MVM-G52 were ineffective in all five. To investigate the underlying mechanism of LuIII's phenotype, we used recombinant parvoviruses with the LuIII capsid replacing the MVMp capsid or with molecular alteration of the P4 promoter. The LuIII capsid enhanced efficient replication and oncolysis in MO59J gliomas cells; other gliomas tested required the entire LuIII genome to exhibit enhanced infection. LuIII selectively infected glioma cells over normal glial cells in vitro. In mouse models, human glioblastoma xenografts were selectively infected by LuIII when administered intratumorally; LuIII reduced tumor growth by 75%. LuIII also had the capacity to selectively infect subcutaneous or intracranial gliomas after intravenous inoculation. Intravenous or intracranial LuIII caused no adverse effects. Intracranial LuIII caused no infection of mature mouse neurons or glia in vivo but showed a modest infection of developing neurons. PMID:22553327

  16. Gamma radiation exposure of accompanying persons due to Lu-177 patients

    NASA Astrophysics Data System (ADS)

    Kovan, Bilal; Demir, Bayram; Tuncman, Duygu; Capali, Veli; Turkmen, Cuneyt

    2015-07-01

    Neuroendocrine tumours (NET) are cancers usually observed and arisen in the stomach, intestine, pancreas and breathing system. Recently, radionuclide therapy applications with Lu-177 peptide compound are rapidly growing; especially effective clinical results are obtained in the treatment of well-differentiated and metastatic NET. In this treatment, Lu-177-DOTA, a beta emitter radioisotope in the radiopharmaceutical form, is given to the patient by intravenous way. Lu-177 has also gamma rays apart from beta rays. Gamma rays have 175 keV average energy and these gamma rays should be under the control in terms of radiation protection. In this study, we measured the exposure dose from the Lu-177 patient.

  17. The role of phosphates for the Lu-Hf chronology of meteorites

    NASA Astrophysics Data System (ADS)

    Debaille, Vinciane; Van Orman, James; Yin, Qing-Zhu; Amelin, Yuri

    2017-09-01

    The 176Lu-176Hf isotopic system is widely used for dating and tracing cosmochemical and geological processes, but still suffers from two uncertainties. First, Lu-Hf isochrons for some early Solar System materials have excess slope of unknown origin that should not be expected for meteorites with ages precisely determined with other isotopic chronometers. This observation translates to an apparent Lu decay constant higher than the one calculated by comparing ages obtained with various dating methods on terrestrial samples. Second, unlike the well constrained Sm/Nd value (to within 2%) for the chondritic uniform reservoir (CHUR), the Lu/Hf ratios in chondrites vary up to 18% when considering all chondrites, adding uncertainty to the Lu/Hf CHUR value. In order to better understand the Lu-Hf systematics of chondrites, we analyzed mineral fractions from the Richardton H5 chondrite to construct an internal Lu-Hf isochron, and set up a numerical model to investigate the effect of preferential diffusion of Lu compared to Hf from phosphate, the phase with the highest Lu-Hf ratio in chondrites, to other minerals. The isochron yields an age of 4647 ± 210 million years (Myr) using the accepted 176Lu decay constant of 1.867 ± 0.008 ×10-11yr-1. Combining this study with the phosphate fractions measured in a previous study yields a slope of 0.08855 ± 0.00072, translating to a 176Lu decay constant of 1.862 ± 0.016 ×10-11yr-1 using the Pb-Pb age previously obtained, in agreement with the accepted value. The large variation of the Lu/Hf phosphates combined with observations in the present study identify phosphates as the key in perturbing Lu-Hf dating and generating the isochron slope discrepancy. This is critical as apatite has substantially higher diffusion rates of rare earth elements than most silicate minerals that comprise stony meteorites. Results of numerical modeling depending of temperature peak, size of the grains and duration of the metamorphic event, show that

  18. Syntheses and structures of mononuclear lutetium imido complexes with very short Lu-N bonds.

    PubMed

    Panda, Tarun K; Randoll, Sören; Hrib, Cristian G; Jones, Peter G; Bannenberg, Thomas; Tamm, Matthias

    2007-12-21

    The reaction of 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-imine (ImDippNH) with trimethylsilylmethyllithium and anhydrous lutetium trichloride affords the imido complex [LuCl2(ImNDipp)(THF)3], which, on further reaction with dipotassium cyclooctatetraenide, K2(C8H8), leads to the half-sandwich cyclooctatetraenyl complex [(eta8-C8H8)Lu(ImNDipp)(THF)2]; both complexes contain very short Lu-N bond lengths, which are shorter than any previously reported Lu-N distances.

  19. Scintillation and luminescence properties of Sm3+-activated Lu2O3-CaO-SiO2-B2O3 (LuCSB) scintillating glasses

    NASA Astrophysics Data System (ADS)

    Kirdsiri, K.; Kaewkhao, J.; Park, J. M.; Ha, D. H.

    2016-09-01

    Lutetium (Lu) is a high atomic number material and readily interacts with X-rays, which makes it a good scintillation material. In this work, Lu-glass scintillators from the series xSm2O3: 25Lu2 O3: 10SiO2: 10CaO: (55- x)B2O3 (LuCSB) were synthesized at 1500 ° C by using a simple melt quenching technique. The influence of the Sm3+ ion on their physical, optical, photo-, X-rayand proton-induced properties has been characterized. The amorphous nature of the samples was confirmed by using X-ray diffraction. The density and the molar volume were found to be increased at higher concentrations of Sm3+. The X-ray- and the proton-induced emission spectra of the Sm3+:LuCSB glasses showed an intense reddish-orange emission around 604 nm (4G5/2 → 6H7/2), which matched the photoluminescence (PL) emission spectrum well. Among the prepared glasses, the 1.0-mol% Sm3+ ion-activated LuCSB glass exhibited the highest value of the characteristic emission parameters. The X-ray-induced luminescence of the LuCSB glass was also compared with that of a commercial bismuth germinate Bi4Ge3O12 (BGO) crystal.

  20. Cocktail Therapy of 177Lu-PSMA-617 and 177Lu-EDTMP in Patients With mCRPC: A Proof-of-Principle Application.

    PubMed

    Bal, Chandrasekhar; Yadav, Madhav Prasad; Ballal, Sanjana

    2016-08-01

    Prostate cancer is the second most common primary tumor affecting men worldwide. Among them, 10-20% develop castration resistant prostate cancer (CRPC). Ga-PSMA-PET/CT is an important theranostic agent for the evaluation of CRPC to assess the feasibility of treatment with Lu-PSMA-617 which is a novel therapeutic agent. Interestingly, in certain cases, we have observed non-PSMA-avid lesions despite raised sPSA levels. In this regard, we present a case of cocktail therapy applied using Lu-PSMA-617 and Lu-EDTMP therapy in a 38-year-old male CRPC patient with both soft tissue and extensive skeletal metastases.

  1. Human erythrocyte antigens. Regulation of expression of a novel erythrocyte surface antigen by the inhibitor Lutheran In(Lu) gene.

    PubMed Central

    Telen, M J; Eisenbarth, G S; Haynes, B F

    1983-01-01

    Our study describes a novel human erythrocyte protein antigen, the expression of which is regulated by the rare Lutheran inhibitor In(Lu) gene. We have produced a monoclonal antibody (A3D8) that bound strongly to erythrocytes from subjects with Lutheran phenotypes Lu(a+b+), Lu(a+b-), and Lu(a-b+) but bound negligibly to erythrocytes from subjects with the dominant form of Lu(a-b-) phenotype, reflecting inheritance of the In(Lu) gene. Importantly, erythrocytes from an individual with the recessive form of Lu(a-b-) phenotype (i.e., absence of the In(Lu) gene and absence of genes encoding for Lutheran antigens) showed reactivity with A3D8 antibody comparable to that seen with Lu(a+) or Lu(b+) erythrocytes. A3D8 antigen activity was also found on all leukocytes and in serum and plasma; this activity also appeared to be regulated by the In(Lu) gene in serum, plasma, and on a subset of leukocytes. Thus, we have identified a human erythrocyte protein whose expression is modified by the In(Lu) gene. This knowledge that such an antigen exists on erythrocytes and in normal plasma should allow further studies into the molecular genetics of the In(Lu) gene and into the functional and structural significance of the A3D8 antigen. PMID:6863545

  2. Lu-177-Labeled Zirconia Particles for Radiation Synovectomy.

    PubMed

    Polyak, Andras; Nagy, Lívia Naszályi; Drotár, Eszter; Dabasi, Gabriella; Jóba, Róbert P; Pöstényi, Zita; Mikolajczak, Renata; Bóta, Attila; Balogh, Lajos

    2015-12-01

    The present article describes the preparation of β-emitter lutetium-177-labeled zirconia colloid and its preliminary physicochemical and biological evaluation of suitability for local radionuclide therapy. The new (177)Lu-labeled therapeutic radiopharmaceutical candidate was based on the synthesis mode of a previously described zirconia nanoparticle system. The size and shape of the developed radiopharmaceutical compound were observed through a scanning electron microscope and dynamic light scattering methods. The radiocolloid had a 1.7 μm mean diameter and showed high in vitro radiochemical and colloid size stability at room temperature and during the blood sera stability test. After the in vitro characterizations, the product was investigated in the course of the treatment of a spontaneously diseased dog veterinary patient's hock joint completed with single-photon emission computed tomography (SPECT) imaging follow-up measurements and a dual-isotope SPECT imaging tests with conventional (99m)Tc-methanediphosphonic acid bone scintigraphy. In the treated dog, no clinical side-effects or signs of histopathological changes of the joints were recorded during the treatment. SPECT follow-up studies clearly and conspicuously showed the localization of the (177)Lu-labeled colloid in the hock joint as well as detectable but negligible leakages of the radiocolloid in the nearest lymph node. On the basis of biological follow-up tests, the orthopedic team assumed that the (177)Lu-labeled zirconia colloid-based local radionuclide therapy resulted in a significant and long-term improvement in clinical signs of the patient without any remarkable side-effects.

  3. Lu-177 DOTATATE dosimetry for neuroendocrine tumor: single center experience

    NASA Astrophysics Data System (ADS)

    Said, MA; Masud, MA; Zaini, MZ; Salleh, RA; Lee, BN; Zainon, R.

    2017-05-01

    Lu-177 labelled with DOTATE is widely acceptable to treat Neuroendocrine Tumor (NET) disease and it better improvement of quality of patients’ life since few years ago. However, the radionuclide toxicity becomes the main limitation of the (NET) treatment. Therefore, we performed a pilot study aimed to estimate radiation absorbed doses to dose-limiting organs to develop a systemic therapy with Lu-177 in NET patients. In this study, five set of planar whole body images was acquired every 0.5 hour, 4 hours, 24 hours, 48 hours and 72 hours after Lu-177 administrations. The planar image acquisition was done using Philip Brightview X with Medium Energy General Purpose Collimator (MEGP) collimator. All patients’ images in Conjugate View (CV) format were transferred into PMOD 3.7 Software for Region of Interest (ROI) analysis. The ROI were drawn at selected organs such as kidneys, liver, spleen and bladder. This study found that the mean absorbed dose for kidneys 0.62 ± 0.26 Gy/GBq, liver 0.63 ± 0.28 Gy/GBq, spleen 0.83 ± 0.73 Gy/GBq and bladder 0.14 ± 0.07 Gy/GBq. The radionuclide kinetic for the whole body 99.7 ± 0.1 percent at 0.5 hours, 79.5 ± 10.7 percent at 4 hours, 56.6 ± 10.3 percent at 24 hours, 43.2 ± 7.9 percent at 48 hours and 37.1 ± 9.0 percent at 72 hours. This study verifies that this planar quantitative method able to determine organ at risk and the result line with other published data.

  4. Cryptococcose neuroméningée et tuberculose osseuse chez un immunocompétent: un cas

    PubMed Central

    Gbané-Koné, Mariam; Ouali, Boubacar; Mègne, Estelle; Diomandé, Mohamed; Coulibaly, Abidou Kawalé; Eti, Edmond; Kouakou, N'zué Marcel

    2015-01-01

    Les auteurs rapportent un cas de cryptococcose neuroméningée (CNM) chez un patient de 39 ans, non infecté par le VIH suivi pour une tuberculose de hanche. Le tableau clinique était celui d'une méningite subaiguë. Le diagnostic a été possible grâce à la mise en évidence de cryptocoques dans le LCR. L’évolution a été satisfaisante sous fluconazole. PMID:26090057

  5. Expedition Seven Lu with EMU in Quest airlock

    NASA Image and Video Library

    2003-09-05

    ISS007-E-14473 (5 September 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, performs routine maintenance on an Extravehicular Mobility Unit (EMU) space suit in the Quest airlock on the International Space Station (ISS). The work represents a mid-term checkout and included emptying and refilling the suit’s water tank and loops, cycling relief valves, checking sensors and collecting data, a leak check and running the suit’s fan for two hours to lubricate it.

  6. Expedition Seven Lu with EMU in Quest airlock

    NASA Image and Video Library

    2003-09-05

    ISS007-E-14472 (5 September 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, performs routine maintenance on an Extravehicular Mobility Unit (EMU) space suit in the Quest airlock on the International Space Station (ISS). The work represents a mid-term checkout and included emptying and refilling the suit’s water tank and loops, cycling relief valves, checking sensors and collecting data, a leak check and running the suit’s fan for two hours to lubricate it.

  7. Expedition Seven Lu with EMU in Quest airlock

    NASA Image and Video Library

    2003-09-05

    ISS007-E-14469 (5 September 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, performs routine maintenance on an Extravehicular Mobility Unit (EMU) space suit in the Quest airlock on the International Space Station (ISS). The work represents a mid-term checkout and included emptying and refilling the suit’s water tank and loops, cycling relief valves, checking sensors and collecting data, a leak check and running the suit’s fan for two hours to lubricate it.

  8. Expedition Seven Lu with EMU in Quest airlock

    NASA Image and Video Library

    2003-09-05

    ISS007-E-14470 (5 September 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, performs routine maintenance on an Extravehicular Mobility Unit (EMU) space suit in the Quest airlock on the International Space Station (ISS). The work represents a mid-term checkout and included emptying and refilling the suit’s water tank and loops, cycling relief valves, checking sensors and collecting data, a leak check and running the suit’s fan for two hours to lubricate it.

  9. A Supernodal Approach to Incomplete LU Factorization with Partial Pivoting

    SciTech Connect

    Li, Xiaoye Sherry; Shao, Meiyue

    2009-06-25

    We present a new supernode-based incomplete LU factorization method to construct a preconditioner for solving sparse linear systems with iterative methods. The new algorithm is primarily based on the ILUTP approach by Saad, and we incorporate a number of techniques to improve the robustness and performance of the traditional ILUTP method. These include the new dropping strategies that accommodate the use of supernodal structures in the factored matrix. We present numerical experiments to demonstrate that our new method is competitive with the other ILU approaches and is well suited for today's high performance architectures.

  10. Edward Lu floats in SM assisted by Kenneth Bowersox

    NASA Image and Video Library

    2003-04-28

    ISS006-E-50604 (28 April 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, floats into the Zvezda Service Module on the International Space Station (ISS), assisted by astronaut Kenneth D. Bowersox, Expedition 6 mission commander. Also pictured are cosmonauts Nikolai M. Budarin (left foreground), Expedition 6 flight engineer, and Yuri I. Malenchenko, Expedition 7 mission commander. Astronaut Donald R. Pettit (out of view), Expedition 6 NASA ISS science officer, photographed this image. Budarin and Malenchenko represent Rosaviakosmos.

  11. Conversion coefficient measurements of 176Lu using ICEBall

    NASA Astrophysics Data System (ADS)

    Battaglia, Anthony A.

    We have studied the multipolarites of several transitions in the nucleus 176Lu. The synthesis of 176Lu in stellar environments is through the slow (s-) neutron capture process. The s-process is responsible for the creation of 50% of the heavy elements and 15-20 nuclei in the s-process are s-process branching points. Branching points determine if the synthesis path will beta-decay or neutron capture. The branching point 176 Lu is only produced via the s-process only and has both a long-lived ground state (K = 7--) of 37.6 Gy and a short-lived isomeric state (K = 0--) at 3.6 h. There is no direct decay to both the isomer and ground state due to selection rules. However, an intermediate state was found at 839 keV in the K = 4-- band and another intermediate state in the K = 4+ band at 709 keV which communicate to both the isomer and ground state. The communication to both the isomer and ground state through the intermediate states affects the final abundances of 176Lu in stellar environments which is sensitive to temperature. The experiment was performed at the University of Notre Dame Nuclear Science Laboratory (NSL) using a 176Yb(p,n) reaction at 7.75 MeV. Gamma-gamma and gamma-electron coincidences were measured for conversion coefficients using the Internal Conversion Electron Ball (ICEBall) array and two HPGe detectors (109% relative efficiency of a 3"x 3" NaI detector at 1332 keV). ICEBall was upgraded at the NSL for an improved efficiency from 6%-15% over 4. A total of 40 conversion cofficcients were measured and 35 multipolarities wer assigned. 17 new conversion coefficients were measured and the corresponding multipolarities were assigned. Levels and spin assignments in both the K = 4+ band and K = 4-- band were verified in the intermediate states that are important for establishing a thermal equilibrium in the s-process.

  12. Chemistry and bifunctional chelating agents for binding (177)Lu.

    PubMed

    Parus, Józef L; Pawlak, Dariusz; Mikolajczak, Renata; Duatti, Adriano

    2015-01-01

    A short overview of fundamental chemistry of lutetium and of structural characteristics of lutetium coordination complexes, as relevant for understanding the properties of lutetium-177 radiopharmaceuticals, is presented. This includes basic concepts on lutetium electronic structure, lanthanide contraction, coordination geometries, behavior in aqueous solution and thermodynamic stability. An illustration of the structure and binding properties of the most important chelating agents for the Lu(3+) ion in aqueous solution is also reported with specific focus on coordination complexes formed with linear and macrocyclic polydentate amino-carboxylate donor ligands.

  13. Growth and luminescent properties of Lu 2SiO 5 and Lu 2SiO 5:Ce single crystalline films

    NASA Astrophysics Data System (ADS)

    Zorenko, Yu.; Nikl, M.; Gorbenko, V.; Savchyn, V.; Voznyak, T.; Kucerkova, R.; Sidletskiy, O.; Grynyov, B.; Fedorov, A.

    2011-04-01

    Single crystalline films (SCF) of Lu 2SiO 5 (LSO) and Lu 2SiO 5:Ce (LSO:Ce) silicates with thickness of 2.5-15 μm were crystallized by liquid phase epitaxy method onto undoped LSO substrates from melt-solution based on PbO-B 2O 3 flux. The scintillation and luminescence properties of LSO:Ce SCF were compared with the properties of LSO:Ce single crystal. The peculiarities of luminescence properties of LSO:Ce SCF in comparison with crystal analog can be due to different distribution of Ce 3+ over the Lu1 and Lu2 positions of LSO host and are further influenced by Pb 2+ flux-originated contamination.

  14. Negative thermal expansion and anomalies of heat capacity of LuB50 at low temperatures.

    PubMed

    Novikov, V V; Zhemoedov, N A; Matovnikov, A V; Mitroshenkov, N V; Kuznetsov, S V; Bud'ko, S L

    2015-09-28

    Heat capacity and thermal expansion of LuB50 boride were experimentally studied in the 2-300 K temperature range. The data reveal an anomalous contribution to the heat capacity at low temperatures. The value of this contribution is proportional to the first degree of temperature. It was identified that this anomaly in heat capacity is caused by the effect of disorder in the LuB50 crystalline structure and it can be described in the soft atomic potential model (SAP). The parameters of the approximation were determined. The temperature dependence of LuB50 heat capacity in the whole temperature range was approximated by the sum of SAP contribution, Debye and two Einstein components. The parameters of SAP contribution for LuB50 were compared to the corresponding values for LuB66, which was studied earlier. Negative thermal expansion at low temperatures was experimentally observed for LuB50. The analysis of the experimental temperature dependence for the Gruneisen parameter of LuB50 suggested that the low-frequency oscillations, described in SAP mode, are responsible for the negative thermal expansion. Thus, the glasslike character of the behavior of LuB50 thermal characteristics at low temperatures was confirmed.

  15. Negative thermal expansion and anomalies of heat capacity of LuB50 at low temperatures

    DOE PAGES

    Novikov, V. V.; Zhemoedov, N. A.; Matovnikov, A. V.; ...

    2015-07-20

    Heat capacity and thermal expansion of LuB50 boride were experimentally studied in the 2–300 K temperature range. The data reveal an anomalous contribution to the heat capacity at low temperatures. The value of this contribution is proportional to the first degree of temperature. It was identified that this anomaly in heat capacity is caused by the effect of disorder in the LuB50 crystalline structure and it can be described in the soft atomic potential model (SAP). The parameters of the approximation were determined. The temperature dependence of LuB50 heat capacity in the whole temperature range was approximated by the summore » of SAP contribution, Debye and two Einstein components. The parameters of SAP contribution for LuB50 were compared to the corresponding values for LuB66, which was studied earlier. Negative thermal expansion at low temperatures was experimentally observed for LuB50. The analysis of the experimental temperature dependence for the Gruneisen parameter of LuB50 suggested that the low-frequency oscillations, described in SAP mode, are responsible for the negative thermal expansion. As a result, the glasslike character of the behavior of LuB50 thermal characteristics at low temperatures was confirmed.« less

  16. Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study

    PubMed Central

    Gao, Yanbin; Gong, Yanbin; Zhou, Hui; Xie, Peifeng; Guan, Song; Yi, Wenming

    2017-01-01

    Tang-luo-ning (TLN) is a traditional Chinese herbal recipe for treating diabetic peripheral neuropathy (DPN). In this study, we investigated mitochondrial protein profiles in a diabetic rat model and explored the potential protective effect of TLN. Diabetic rats were established by injection of streptozocin (STZ) and divided into model, alpha lipoic acid (ALA), and TLN groups. Mitochondrial proteins were isolated from dorsal root ganglia and proteomic analysis was used to quantify the differentially expressed proteins. Tang-luo-ning mitigated STZ-induced diabetic symptoms and blood glucose level, including response time to cold or hot stimulation and nerve conductive velocity. As compared to the normal, there were 388 differentially expressed proteins in the TLN group, 445 in ALA group, and 451 in model group. As compared to the model group, there were 275 differential proteins in TLN group and 251 in ALA group. As compared to model group, mitochondrial complex III was significantly decreased, while glutathione peroxidase and peroxidase were increased in TLN group. When compared with ALA group, the mitochondrial complex III was increased, and mitochondrial complex IV was decreased in TLN group. Together, TLN should have a strong antioxidative activity, which appears to be modulated through regulation of respiratory complexes and antioxidases. PMID:28133612

  17. Stellar neutron capture cross sections of the Lu isotopes

    SciTech Connect

    Wisshak, K.; Voss, F.; Kaeppeler, F.; Kazakov, L.

    2006-01-15

    The neutron capture cross sections of {sup 175}Lu and {sup 176}Lu have been measured in the energy range 3-225 keV at the Karlsruhe 3.7 MV Van de Graaff accelerator. Neutrons were produced via the {sup 7}Li(p,n){sup 7}Be reaction by bombarding metallic Li targets with a pulsed proton beam, and capture events were registered with the Karlsruhe 4{pi} barium fluoride detector. The cross sections were determined relative to the gold standard using isotopically enriched as well as natural lutetium oxide samples. Overall uncertainties of {approx}1% could be achieved in the final cross section ratios to the gold standard, about a factor of 5 smaller than in previous works. Maxwellian averaged neutron capture cross sections were calculated for thermal energies between kT = 8 and 100 keV. These values are systematically larger by {approx}7% than those reported in recent evaluations. These results are of crucial importance for the assessment of the s-process branchings at A 175/176.

  18. Femtosecond Spectroscopy of LuMnO3

    NASA Astrophysics Data System (ADS)

    Lou, Shitao; Zimmermann, Frank M.; Bartynski, Robert A.; Hur, Namjun; Cheong, Sang-Wook

    2006-03-01

    Hexagonal LuMnO3 manganite is a ferroelectric and strongly frustrated antiferromagnetic crystal. Strong coupling between lattice, electronic, and magnetic degrees of freedom makes it a promising electronic material. We have used femtosecond pump-probe spectroscopy to study the interaction of electron excitations with lattice vibrations in real time. Optical excitation of a Mn d(x^2-y^2),(xy)->d(3z^2-r^2)transition served as the primary excitation step. With both pump and probe beam polarization perpendicular to the c axis, the probe reflectivity shows a sharp drop due to saturation of the transition, recovering on a timescale of 1 ps. We also observed displacive excitation of a coherent optical phonon vibration at 3.6 THz, which is assigned to an A1 symmetry mode involving Lu ion motion along the c axis. This mode was excited in longitudinal (LO) and transverse mode (TO) geometries. While the LO-TO frequency splitting is small (<0.1 THz), a remarkable phase reversal of the reflectivity curve was observed. This is attributed to a large linear electro-optic effect (Pockels effect), induced by the THz electric field associated with the LO mode.

  19. Thermal neutron capture cross section for the K isomer {sup 177}Lu{sup m}

    SciTech Connect

    Belier, G.; Roig, O.; Daugas, J.-M.; Giarmana, O.; Meot, V.; Letourneau, A.; Marie, F.; Foucher, Y.; Aupiais, J.; Abt, D.; Jutier, Ch.; Le Petit, G.; Bettoni, C.; Gaudry, A.; Veyssiere, Ch.; Barat, E.; Dautremer, T.; Trama, J.-Ch.

    2006-01-15

    The thermal neutron radiative capture cross section for the K isomeric state in {sup 177}Lu has been measured for the first time. Several {sup 177}Lu{sup m} targets have been prepared and irradiated in various neutron fluxes at the Lauee Langevin Institute in Grenoble and at the CEA reactors OSIRIS and ORPHEE in Saclay. The method consists of measuring the {sup 178}Lu activity by {gamma}-ray spectroscopy. The values obtained in four different neutron spectra have been used to calculate the resonance integral of the radiative capture cross section for {sup 177}Lu{sup m}. In addition, an indirect method leads to the determination of the {sup 177}Lu{sup g} neutron radiative capture cross section.

  20. Magnetic properties of Ho1- x Lu x B12 solid solutions

    NASA Astrophysics Data System (ADS)

    Gabáni, S.; Gaz̆o, E.; Pristás̆, G.; Takác̆ová, I.; Flachbart, K.; Shitsevalova, N.; Siemensmeyer, K.; Sluchanko, N.

    2013-05-01

    Magnetic properties of the geometrically frustrated antiferromagnet HoB12 (with T N = 7.4 K) modified by substitution of magnetic Ho atoms through non-magnetic Lu ones are presented and discussed. In this case, in Ho1- x Lu x B12 solid solutions, both chemical pressure resulting from different Lu3+ and Ho3+ radii and magnetic dilution take place with increasing Lu content ( x) that change properties of the system. The received results show strong indication for the existence of a quantum critical point near x = 0.9, which separates the region of magnetic order (starting with HoB12 for x = 0) and the nonmagnetic region (ending with superconducting LuB12 for x = 1).

  1. Green and red luminescence in co-precipitation synthesized Pr:LuAG nanophosphor

    SciTech Connect

    Kumar, S. Arun; Kumar, K. Ashok; Gunaseelan, M.; Senthilselvan, J.; Asokan, K.

    2016-05-06

    Pr:LuAG nanophosphor is an effective candidate in magnetic resonance imaging coupled positron emission tomography (MRI-PET) for medical imaging and scintillator applications. LuAG:Pr (0.05, 0.15 mol%) nanoscale ceramic powders were synthesized by co-precipitation method using urea as precipitant. Effect of antisite defect on structure and luminescence behavior was investigated. Pr:LuAG nanoceramic powders are found crystallized in cubic structure by high temperature calcination at 1400 °C and it shows antisite defect. HR-SEM analysis revealed spherically shaped Pr:LuAG nanoceramic particulate powders with ∼100 nm size. By the excitation at 450 nm, Pr:LuAG nanophosphor exhibit green to red luminescence in the wavelength range of 520 to 680 nm, which is originated from multiplet transition of Pr{sup 3+} ions.

  2. Implications of garnet resorption for the Lu-Hf garnet geochronometer: Makhevinekh Lake Pluton aureole, Labrador

    NASA Astrophysics Data System (ADS)

    Kelly, E. D.; Carlson, W. D.; Connelly, J.

    2009-12-01

    In the contact aureole of the Makhevinekh Lake Pluton (MLP), Labrador, garnet resorption caused redistribution of Lu and loss of Hf, creating spuriously young Lu-Hf ages. Resetting of the Lu-Hf system by contact metamorphic heating is not primarily responsible for progressively younger ages toward the MLP; instead, ages depend upon the degree of garnet resorption and the original core-to-rim Lu zoning. Garnet grew during granulite-facies regional metamorphism at 1850 Ma. At 1322 Ma, garnet rims were replaced by coronas of opx + crd during contact metamorphism. Garnet-rutile and garnet-ilmenite Lu-Hf geochronology using bulk garnet separates yields ages younging from 1878 ±22 Ma at 4025 m from the contact to 1397 ±8 Ma at 450 m from the contact. Toward the contact, garnet Lu/Hf ratios increase and garnet crystals are progressively more resorbed. Concentrations of Lu measured by LA-ICP-MS along radial traverses on central sections through relict garnets decrease gently away from the cores but rise steeply within 50-200 microns of the edge of the relict garnet. Enrichments of Lu in rims of relict garnets demonstrate strong partitioning of Lu into garnet during resorption and limited intracrystalline diffusion of Lu during contact metamorphism. Hf distributions could not be measured, but considering the strong incompatibility of Hf with garnet, it is likely that all Hf in resorbed portions of the garnets was lost from the crystals. We hypothesize that Lu-Hf ages in the aureole are controlled predominantly by retention of Lu and loss of Hf during garnet resorption. We tested this hypothesis with a simple numerical model in which we treat a population of garnets of uniform size with identical original Lu growth zoning. The model simulates: (1) Lu-Hf decay for a specified period before resorption; (2) retention of Lu and loss of Hf from the rim during instantaneous resorption; and (3) Lu-Hf decay during a specified period after resorption. We varied the volume fraction

  3. Lu3+/Yb3+ and Lu3+/Er3+ co-doped antimony selenide nanomaterials: synthesis, characterization, and electrical, thermoelectrical, and optical properties

    PubMed Central

    2013-01-01

    Lu3+/Yb3+ and Lu3+/Er3+ co-doped Sb2Se3 nanomaterials were synthesized by co-reduction method in hydrothermal condition. Powder X-ray diffraction patterns indicate that the LnxLn′xSb2−2xSe3 Ln: Lu3+/Yb3+ and Lu3+/Er3+ crystals (x = 0.00 − 0.04) are isostructural with Sb2Se3. The cell parameters were increased for compounds upon increasing the dopant content (x). Scanning electron microscopy and transmission electron microscopy images show that co-doping of Lu3+/Yb3+ ions in the lattice of Sb2Se3 produces nanorods, while that in Lu3+/Er3+ produces nanoparticles, respectively. The electrical conductivity of co-doped Sb2Se3 is higher than that of the pure Sb2Se3 and increases with temperature. By increasing the concentration of Ln3+ions, the absorption spectrum of Sb2Se3 shows red shifts and some intensity changes. In addition to the characteristic red emission peaks of Sb2Se3, emission spectra of co-doped materials show other emission bands originating from f-f transitions of the Yb3+ ions. PMID:23537193

  4. The infrared radiation spectrum of acupoint taiyuan (LU 9) in asthma patients.

    PubMed

    Zhou, Yu; Shen, Xue-yong; Wang, Li-zhen; Wei, Jian-zi; Cheng, Ke

    2012-06-01

    To analyze the distinctive pathological characteristics in the spectrums of spontaneous infrared radiation at the Taiyuan (LU 9) acupoint in patients with asthma. A highly sensitive infrared spectrum detecting device was used to detect the spectrums of spontaneous infrared radiation at Taiyuan (LU 9) in 37 asthma patients and 34 healthy volunteers. Asthma patients had significantly lower infrared intensity than that of the healthy volunteers (P>0.01). Asthma patients had significantly lower overall infrared radiation intensity at the left Taiyuan (LU 9) than that of healthy volunteers (P > 0.05), but there was no significant difference between healthy volunteers and asthma patients at the right Taiyuan (LU 9) (P > 0.05). The infrared radiation intensity of 17 wavelength spots at the left Taiyuan (LU 9) and 4 wavelength spots at the right Taiyuan (LU 9) in asthma patients were significantly lower than those of healthy volunteers (P > 0.05). At 2 microm, the infrared radiation intensity of asthma patients was significantly stronger than that of healthy volunteers (P > 0.05). At 19 wavelength spots in the healthy volunteers and at 4 wave-length spots in the asthma patients, the left Taiyuan (LU 9) showed a significantly stronger intensity than that of the right Taiyuan (LU 9) (P > 0.05S). By Pearson's chi2 test, healthy volunteers had more wavelength spots that were significantly different between the left and right Taiyuan (LU 9) than the asthma patients (P > 0.01). Changes in the infrared spectrum at the Taiyuan (LU 9) acupoint in asthma patients may reflect distinct pathological changes. Certain acupuncture points may be related to specific organs.

  5. Crystallization-Dependent Luminescence Properties of Ce:LuPO4.

    PubMed

    Sun, Congting; Li, Xingxing; Wang, Hao; Xue, Dongfeng

    2016-03-21

    The luminescence properties of Ce:LuPO4 depend on both the Ce(3+) center and the host lattice. In this article, we studied the dependence of the luminescence properties of Ce:LuPO4 on both the doping concentration of Ce(3+) and the size and morphology of the LuPO4 matrix at micro- and nanosize regimes. The crystalline behavior of Ce:LuPO4, including its size and shape, was investigated via precursor transformation crystallization. On the basis of this crystallization approach, Ce:LuPO4 hollow nanospheres, nanorods, and regular tetrahedrons were obtained. For micro- and nanostructured Ce:LuPO4, the surface-induced chemical bonding architecture can be effectively varied by controlling the size of the crystalline material and its geometry. Our experimental observations demonstrate that one-dimensional Ce:LuPO4 nanorods doped with 0.1 mol % Ce(3+) possess the best performance among the as-prepared samples. The significant anisotropy of Ce:LuPO4 nanorods can result in a larger specific surface area and enhanced luminescence properties. Moreover, the improved luminescence property of Ce:LuPO4 nanostructures can also be optimized by increasing the preferential anisotropic chemical bonding architecture to regulate the 5d level of Ce(3+). Our work also shows that the photoluminescence emission intensity of Ce:LuPO4 nanorods is increased as the surface area normal to their axial direction increases. From the standpoint of crystallization, the luminescence properties of Ce(3+) in nano- and microsize matrixes can be well-optimized by controlling the crystalline behavior of the host lattice under proper synthesis conditions.

  6. Quasi-spherical LuBO{sub 3} nanoparticles: Synthesis, formation, and luminescence properties

    SciTech Connect

    Gao, Yu; Yang, Feng; Han, Wenchi; Fang, Qinghong; Xu, Zhenhe

    2014-03-01

    Graphical abstract: Quasi-spherical LuBO3 nanoparticles have been prepared via a facile hydrothermal route. The possible growth mechanism and the luminescent properties of the as-prepared microcrystals have been discussed. - Highlights: • LuBO{sub 3} nanoparticles were prepared by a facile hydrothermal route. • The Eu{sup 3+} and Tb{sup 3+}-doped LuBO{sub 3} products show strong red and green emissions. • This method may be more widely applicable in the design of other rare-earth compounds. - Abstract: Quasi-spherical LuBO{sub 3} nanoparticles have been successfully synthesized by a designed hydrothermal conversion method. The Lu(OH)CO{sub 3} nanoparticles were first prepared by a simple homogeneous precipitation method. Subsequently, LuBO{sub 3} nanoparticles were synthesized at the expense of the Lu(OH)CO{sub 3} nanoparticles during a hydrothermal conversion process. The conversion process from the Lu(OH)CO{sub 3} precursor to LuBO{sub 3} nanoparticles was investigated by time-dependent experiments. Moreover, the as-obtained Eu{sup 3+} and Tb{sup 3+}-doped LuBO{sub 3} products show strong characteristic red and green emissions under ultraviolet excitation and low-voltage electron beam excitation, respectively. This work sheds some light on the knowledge of conversion of different kind of lutetium compounds, and the luminescent properties have potential applications in fluorescent lamps and field emission displays. More importantly, this simple method is expected to allow the large-scale production of other complex rare-earth compounds with controllable morphologies and sizes, and exploration of the morphology and photoluminescence properties.

  7. Pharmacodynamics and potential synergistic effects of Mai-Luo-Ning injection on cardiovascular protection, based on molecular docking.

    PubMed

    Wu, Liang; Shen, Han-Yuan; Wu, Yu-Zheng; Yu, Xiao-Yi; Wang, Hong; Cheng, Xue-Fang; Wang, Guang-Ji; Hao, Hai-Ping

    2015-11-01

    As a computer-assisted approach, molecular docking has been universally applied in drug research and development and plays an important role in the investigation and evaluation of herbal medicines. Herein, the method was used to estimate the pharmacodynamics of Mai-Luo-Ning injection, a traditional Chinese compound herbal prescription. Through investigating the interactions between several important proteins in cardiovascular system and characteristic components of the formula, its effect on cardiovascular protection was evaluated. Results showed the differences in the interactions between each component and the selected target proteins and revealed the possible mechanisms for synergistic effects of various characteristic components on cardiovascular protection. The study provided scientific evidence supporting the mechanistic study of the interactions among multi-components and targets, offering a general approach to investigating the pharmacodynamics of complicated materials in compound herbal prescriptions.

  8. Co-precipitation synthesis of lutetium aluminum garnet (LuAG) powders: The influence of ethanol

    NASA Astrophysics Data System (ADS)

    Pan, Liangjie; Jiang, Benxue; Fan, Jintai; Zhang, Pande; Mao, Xiaojian; Zhang, Long

    2017-09-01

    Aluminum Garnet (LuAG) precursors were co-precipitated by using ethanol-water as the precipitant solvent. The effect of different volume ratios of ethanol to water (R) on the preparation of pure-phase LuAG powders has been mainly studied. The evolution of phase, composition and micro-structure of the as-synthesized LuAG powders were characterized by TG/DTA, FTIR, XRD, BET, and SEM. The BET-equivalent diameter of LuAG nano particles increased with R. The ethanol-water solvent does not change the main composition of the LuAG precursors, but has great influence on the morphology of the final LuAG nano particles. Uniformly dispersed LuAG powders calcined at 1200 °C for 3 h with a particle size of approximately 120 nm were obtained by using ethanol-water solvent with proper R = 1. The mechanism of ethanol in the preparation process was discussed.

  9. Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety.

    PubMed

    Adell, Albert

    2010-12-01

    Lu-AA21004, an oral, multimodal serotonergic agent, is currently under development by H Lundbeck and Takeda Pharmaceutical, for the potential treatment of depression and anxiety. Lu-AA21004 belongs to a novel chemical class of antidepressant agents, the bisarylsulfanyl amines, and possesses a novel pharmacological profile, with activity at serotonergic receptors 5-HT3, 5-HT7 and 5-HT1A, and also at the 5-HT transporter. Acute administration of Lu-AA21004 in rats inhibited the firing activity of serotonergic neurons of the dorsal raphe nucleus through 5-HT3 receptor blockade, with rapid recovery of firing activity upon cessation of treatment compared with an antidepressant of the SSRI class. Results from phase II clinical trials have reported improvement in depression and anxiety symptoms after 6 weeks of treatment. Lu-AA21004 was generally well tolerated, with adverse events related to sexual dysfunction occurring in a lower number of patients receiving Lu-AA21004 compared with venlafaxine. Phase III clinical trials with Lu-AA21004 in patients with major depressive disorder are underway and phase III trials in patients with generalized anxiety disorder have been completed. If initial outcomes from these clinical trials prove positive, Lu-AA21004 may pave the way for new multimodal therapies for the treatment of depression and anxiety.

  10. Lu-Hf and Sm-Nd evolution in lunar mare basalts

    NASA Technical Reports Server (NTRS)

    Unruh, D. M.; Tatsumoto, M.; Stille, P.; Patchett, P. J.

    1984-01-01

    Existing cumulate remelting models for mare basalt genesis are evaluated in light of Lu-Hf, Rb-Sr, Sm-Nd data and overall REE characteristics in order to determine the simplest model that can account for these data. A data base for comparing Lu-Hf evolution in the lunar mantle as inferred from Lu-Hf analyses of oceanic basalts is presented along with a preliminary comparison of Lu-Hf and Sm-Nd evolution betwee mare basalts and terrestrial oceanic basalts. It is found that Lu/Hf characteristics of mare basalts cannot be explained in terms of modal melting of cumulate sources formed from a magma ocean with chondritic Lu/Hf. The data are consistent with a model in which the cumulate sources formed from a light REE + HF-enriched magma ocean. Nonmodal melting of ilmenite in the sources is also required. The Lu-Hf data suggest that even the high-Ti basalt sources contained no more than about 3 percent ilmenite.

  11. Innovative LuYAP:Ce array for PET imaging

    NASA Astrophysics Data System (ADS)

    Cinti, M. N.; Scafe, R.; Bennati, P.; Lo Meo, S.; Frantellizzi, V.; Pellegrini, R.; De Vincentis, G.; Sacco, D.; Fabbri, A.; Pani, R.

    2017-03-01

    We present an imaging characterization of a 10 × 10 LuYAP array (2 × 2 × 10 mm3 pixels) with an innovative dielectric coating insulation (0.015 mm thick), in view of its possible use in a gamma camera for imaging positron emission tomography (PET) or in similar applications, e.g. as γ -prompt detector in hadron therapy. The particular assembly of this array was realized in order to obtain a packing fraction of 98%, improving detection efficiency and light collection. For imaging purpose, the array has been coupled with a selected Hamamatsu H10966-100 Multi Anode Photomultiplier read out by a customized 64 independent channels electronics. This tube presents a superbialkali photocathode with 38% of quantum efficiency, permitting to enhance energy resolution and consequently image quality. A pixel identification of about 0.5 mm at 662 keV was obtained, highlighting the potentiality of this detector in PET applications.

  12. Spectral ordering techniques for incomplete LU preconditoners for CG methods

    NASA Technical Reports Server (NTRS)

    Clift, Simon S.; Simon, Horst D.; Tang, Wei-Pai

    1995-01-01

    The effectiveness of an incomplete LU (ILU) factorization as a preconditioner for the conjugate gradient method can be highly dependent on the ordering of the matrix rows during its creation. Detailed justification for two heuristics commonly used in matrix ordering for anisotropic problems is given. The bandwidth reduction and weak connection following heuristics are implemented through an ordering method based on eigenvector computations. This spectral ordering is shown to be a good representation of the heuristics. Analysis and test cases in two and three dimensional diffusion problems demonstrate when ordering is important, and when an ILU decomposition will be ordering insensitive. The applicability of the heuristics is thus evaluated and placed on a more rigorous footing.

  13. Quadrupole moments of wobbling excitations in 163Lu

    SciTech Connect

    Gorgen, A.; Clark, R.M.; Cromaz, M.; Fallon, P.; Hagemann, G.B.; Hubel, H.; Lee, I.Y.; Macchiavelli, A.O.; Sletten, G.; Ward, D.; Bengtsson, R.

    2004-01-01

    Lifetimes of states in the triaxial strongly deformed bands of {sup 163}Lu have been measured in a Gammasphere experiment using the Doppler-shift attenuation method. The bands are interpreted as wobbling-phonon excitations from the characteristic electromagnetic properties of the transitions connecting the bands. Quadrupole moments were extracted for the 0-phonon yrast band and, for the first time, for the 1-phonon wobbling band. The very similar results found for both bands suggest a similar intrinsic structure confirming the wobbling interpretation. While the in-band quadrupole moments for the bands show a decreasing trend towards higher spin, the strength of the inter-band transitions remains constant. Both features can be understood by a small increase in triaxiality towards higher spin. Such a change in triaxiality is also found in cranking calculations, to which the experimental results are compared.

  14. Ho:Tm:Er:LuAG and Two Wavelength Oscillation

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.; Murray, Keith E.; Walsh, Brian M.; Hutcheson, Ralph L.

    1997-01-01

    Ho:Tm:Er:LuAG demonstrated simultaneous laser oscillation associated with two different transitions and different atoms. Two wavelength oscillation, or TWO, can be achieved in a single laser and single resonator. Moreover, the wavelength can be electronically controlled by varying the pump pulse length, Either the short wavelength, the Ho (5)1(sub 7) to (5)1(sub 8) transition at 2.1 microns, or the long wavelength, the Er (4)1(sub 11/2) to (4)1(sub 13/2) transition at 2.7 microns, or both wavelengths simultaneously can be produced without resorting to mechanical intervention. Consequently, a single laser system can easily switch between producing either of these useful wavelengths. Laser operation of both transitions has been characterized and is presented.

  15. Multiferroic behavior in Lu2MnCoO6

    NASA Astrophysics Data System (ADS)

    Zapf, Vivien; Mun, E.-D.; Ueland, B. G.; Thompson, J. D.; Singleton, J.; Gardner, J.; Yáñez-Vilar, S.; Sánchez-Anduacute; jar; , M.; Señaris-Rodriguez, M. A.; Mira, J.; Biskup, N.; Batista, C. D.

    2012-02-01

    Lu2MnCoO6 is a new member of the multiferroics with coupling between net magnetization and net electric polarization. Similar to Ca3MnCoO6, an up-up-down-down order of the magnetic spins is found that breaks spatial-inversion symmetry and creates an electric polarization. Unlike Ca3MnCoO6, the Co and Mn ions are both in a S = 3/2 state, the ordering temperature is 42 K, and the magnetic field needed to suppress electric polarization is 2 T. We present an experimental study of the multiferroic properties and spin structure including neutron diffraction, electric polarization, magnetization, dielectric constant, and specific heat measurements.

  16. Influence of Eu(3+) doping content on antioxidant properties of Lu2O3 sol-gel derived nanoparticles.

    PubMed

    Olvera Salazar, Arturo; García Hernández, Margarita; López Camacho, Perla Yolanda; López Marure, Arturo; Reyes de la Torre, Adriana Isabel; Morales Ramírez, Ángel de Jesús; Hernández Santiago, Felipe; Aguilera Vázquez, Luciano

    2016-12-01

    This paper presents the synthesis of pure and europium-doped lutetium oxide (Lu2O3) powders prepared by sol-gel method. The influence of europium ion concentration into Lu2O3 nanocrystallites was investigated for first time in an in vitro system using a modified ABTS radical cation decolorization assay to determine the antioxidant activity. The crystalline structure of Lu2O3 and Eu:Lu2O3 powders was elucidated by XRD obtaining cubic phase in all system without secondary products in accordance with FT-IR results. By TEM and Scherrer equation, it was determined that Lu2O3 and Eu:Lu2O3 powders presented nearly spherical particle morphology with crystallites sizes in the range of 8 to 13nm. The antioxidant assays results revealed that europium ion enhance Lu2O3 powders antioxidant properties, showing that 12.5mol% of europium is sufficient to reach its maximum capacity.

  17. Checking Timed Büchi Automata Emptiness Using LU-Abstractions

    NASA Astrophysics Data System (ADS)

    Li, Guangyuan

    This paper shows that the zone-based LU-extrapolation of Behrmann et al, that preserves reachability of timed automata, also preserves emptiness of timed Büchi automata. This improves the previous results by Tripakis et al who showed that the k-extrapolation preserves timed Büchi automata emptiness. The LU-extrapolation is coarser than k-extrapolation, allowing better state space reductions. A tool with LU-extrapolation for emptiness checking of timed Büchi automata has been implemented, and some experiments are reported.

  18. Lu-hf total-rock isochron for the eucrite meteorites

    USGS Publications Warehouse

    Patchett, P.J.; Tatsumoto, M.

    1980-01-01

    The isotope 176Lu (2.6% of natural lutetium) decays by ??- to 176Hf, with a long half life. We present here the first Lu-Hf isochron. The eucrite meteorites, a suite of planetary igneous rocks of known age, 4,550 Myr, define a 10-point total-rock isochron with a slope of 0.0934 ?? 40, leading to a value of 3.53 ?? 0.14 ??1010yr for the ??--decay half life of 176Lu. The isochron intercept of 0.27973 ?? 12 gives the initial 176Hf/177Hf for the inner Solar System at the time of accretion. ?? 1980 Nature Publishing Group.

  19. Langston University - High Energy Physics (LU-HEP)

    SciTech Connect

    Snow, Dr., Joel

    2012-08-13

    This final report is presented by Langston University (LU) for the project entitled "Langston University High Energy Physics" (LUHEP) under the direction of principal investigator (PI) and project director Professor Joel Snow. The project encompassed high energy physics research performed at hadron colliders. The PI is a collaborator on the DZero experiment at Fermi National Accelerator Laboratory in Batavia, IL, USA and the ATLAS experiment at CERN in Geneva, Switzerland and was during the entire project period from April 1, 1999 until May 14, 2012. Both experiments seek to understand the fundamental constituents of the physical universe and the forces that govern their interactions. In 1999 as member of the Online Systems group for Run 2 the PI developed a cross-platform Python-based, Graphical User Interface (GUI) application for monitoring and control of EPICS based devices for control room use. This served as a model for other developers to enhance and build on for further monitoring and control tasks written in Python. Subsequently the PI created and developed a cross-platform C++ GUI utilizing a networked client-server paradigm and based on ROOT, the object oriented analysis framework from CERN. The GUI served as a user interface to the Examine tasks running in the D\\O\\ control room which monitored the status and integrity of data taking for Run 2. The PI developed the histogram server/control interface to the GUI client for the EXAMINE processes. The histogram server was built from the ROOT framework and was integrated into the D\\O\\ framework used for online monitoring programs and offline analysis. The PI developed the first implementation of displaying histograms dynamically generated by ROOT in a Web Browser. The PI's work resulted in several talks and papers at international conferences and workshops. The PI established computing software infrastructure at LU and U. Oklahoma (OU) to do analysis of DZero production data and produce simulation data

  20. Luminescence properties of Lu3Al5O12:Tb3+ nano-garnet

    NASA Astrophysics Data System (ADS)

    Praveena, R.; Shim, Jae Jeong; Cai, Peiqing; Seo, Hyo Jin; Chung, Wan-Young; Kwon, Tae Ha; Jayasankar, C. K.; Haritha, P.; Venkatramu, V.

    2014-06-01

    Trivalent terbium-doped lutetium-aluminate nano-garnet (Lu3Al5O12:Tb3+) powder was prepared by using the Pechini sol-gel process. The structure and crystallinity of the Lu3Al5O12:Tb3+ nano-garnet were characterized by using X-ray diffraction, transmission electron microscopy and Fourier transform infrared spectroscopy. The green emission of Tb3+ ions is observed at 545 nm corresponding to the 5D4 → 7F5 transition under the 271-nm excitation. The temperature dependent luminescence properties of the Lu3Al5O12:Tb3+ nano-garnet are investigated. The results show that the present garnet exhibits better thermal stability than the other green emitting phosphors, hence, the Lu3Al5O12:Tb3+ phosphor is a promising candidate for light-emitting devices.

  1. Fabrication and characterization of Eu3+-doped Lu2O3 scintillation ceramics

    NASA Astrophysics Data System (ADS)

    Kopylov, Yu. L.; Kravchenko, V. B.; Dulina, N. A.; Lopin, А. V.; Parkhomenko, S. V.; Tolmachev, A. V.; Yavetskiy, R. P.; Zelenskaya, O. V.

    2013-02-01

    Density, morphology, optical transmittance and luminescence of undoped and europium-doped Lu2O3 ceramics have been studied. It has been revealed that europium ions in concentration of 5 at.% act as a solid-state sintering aids in Lu2O3 ceramics promoting its densification. Lu2O3:Eu3+ optical ceramics with relative density of 98 ± 2%, with an average grain size of 50 μm and in-line transmittance of 41% in the visible wavelength range has been produced by vacuum sintering at Т = 1850 °С. The scintillation characteristics of Lu2O3:Eu3+ ceramics under excitation with α-particles (238Рu source, E = 5.46 МeV) have been determined for the first time (S = 500 ± 50 photons/МeV, R = 26.5%).

  2. Lu & Malenchenko work on storage batteries in Zvezda taken during STS-106

    NASA Image and Video Library

    2000-09-13

    STS106-388-011 (8-20 September 2000) --- Cosmonaut Yuri I. Malenchenko (top), and astronaut Edward T. Lu, both mission specialists, work inside panels in the Zvezda Service Module on the International Space Station (ISS). Malenchenko represents Rosaviakosmos.

  3. Intrinsic magnetic properties of hexagonal LuFeO{sub 3} and the effects of nonstoichiometry

    SciTech Connect

    Moyer, Jarrett A. E-mail: schlom@cornell.edu; Schiffer, Peter; Misra, Rajiv; Mundy, Julia A.; Brooks, Charles M.; Heron, John T.; Muller, David A.; Schlom, Darrell G. E-mail: schlom@cornell.edu

    2014-01-01

    We used oxide molecular-beam epitaxy in a composition-spread geometry to deposit hexagonal LuFeO{sub 3} (h-LuFeO{sub 3}) thin films with a monotonic variation in the Lu/Fe cation ratio, creating a mosaic of samples that ranged from iron rich to lutetium rich. We characterized the effects of composition variation with x-ray diffraction, atomic force microscopy, scanning transmission electron microscopy, and superconducting quantum interference device magnetometry. After identifying growth conditions leading to stoichiometric film growth, an additional sample was grown with a rotating sample stage. From this stoichiometric sample, we determined stoichiometric h-LuFeO{sub 3} to have a T{sub N} = 147 K and M{sub s} = 0.018 μ{sub B}/Fe.

  4. [Anatomical education in the late Meiji era --Lu Xun, doctor Fujino and their comtemporaries].

    PubMed

    Sakai, Tatsuo

    2007-03-01

    Lu Xun studied medicine at Sendai Medical School for 1 and a half years and then changed his course to Literature. In his novel "Doctor Fujino", Lu Xun told his memory on the anatomical notes in which Professor Fujino made numerous corrections. I analyzed the anatomical notes by Lu Xun and his classmates, and revealed the situation of lectures at that time. The teachers drew many anatomical illustrations on the black board with colored chalks. The lecture notes of students may be either clean copies rewritten after lectures or crude notes written during the lectures. When making clean copies, they copied anatomical illustrations in the anatomical textbooks at hand. The anatomical textbooks by Gegenbaur, Rauber and Ishikawa were utilized. Lu Xun made clean copies in the first two months after matriculation, and made crude notes after then. Corrections by Professor Fujino were found in the crude notes for his lectures.

  5. Influence of magnetic on ferroelectric ordering in LuMnO3

    NASA Astrophysics Data System (ADS)

    van Aken, Bas B.; Palstra, Thomas T.

    2004-04-01

    We have studied the influence of antiferromagnetic ordering on the local dielectric moments of the MnO5 and LuO7 polyhedra by measuring neutron powder-diffraction patterns of LuMnO3 at temperatures near TN. We show that the coupling is weak, because the magnetic exchange coupling is predominantly in the ab plane of the MnO5 trigonal bipyramids, and the electric dipole moments, originating in the LuO7 polyhedra, are oriented along the hexagonal c axis. Anomalies in the dielectric properties near TN are thus caused by the geometric constraints between the MnO5 and the LuO7 polyhedra.

  6. High-light-output scintillator for photodiode readout: LuI3:Ce3+

    NASA Astrophysics Data System (ADS)

    Birowosuto, M. D.; Dorenbos, P.; van Eijk, C. W. E.; Krämer, K. W.; Güdel, H. U.

    2006-06-01

    In this paper, we investigated the scintillation properties of LuI3:Ce3+. Radioluminescence, light output, energy resolution, and γ-scintillation decay are reported. We find an extremely high light output of 98 000+/-10 000 photons/MeV. LuI3:Ce3+ also gives a very high electron-hole (e-h) pair response when it is coupled with an avalanche photodiode (APD) (92 000+/-9000 e-h pairs/MeV). With an APD, a best energy resolution (full width at half maximum over the peak position) of 3.3%+/-0.3% for 662 keV γ quanta is observed. A combination of an extremely high light output and a good energy resolution makes LuI3:Ce3+ an ideal scintillator for radiation sensor applications. Some drawbacks due to the hygroscopicity and the difficult growth of LuI3:Ce3+ crystals are also discussed.

  7. Multimodal Somatostatin Receptor Theranostics Using [64Cu]Cu-/[177Lu]Lu-DOTA-(Tyr3)octreotate and AN-238 in a Mouse Pheochromocytoma Model

    PubMed Central

    Ullrich, Martin; Bergmann, Ralf; Peitzsch, Mirko; Zenker, Erik F.; Cartellieri, Marc; Bachmann, Michael; Ehrhart-Bornstein, Monika; Block, Norman L.; Schally, Andrew V.; Eisenhofer, Graeme; Bornstein, Stefan R.; Pietzsch, Jens; Ziegler, Christian G.

    2016-01-01

    Pheochromocytomas and extra-adrenal paragangliomas (PHEO/PGLs) are rare catecholamine-producing chromaffin cell tumors. For metastatic disease, no effective therapy is available. Overexpression of somatostatin type 2 receptors (SSTR2) in PHEO/PGLs promotes interest in applying therapies using somatostatin analogs linked to radionuclides and/or cytotoxic compounds, such as [177Lu]Lu-DOTA-(Tyr3)octreotate (DOTATATE) and AN-238. Systematic evaluation of such therapies for the treatment of PHEO/PGLs requires sophisticated animal models. In this study, the mouse pheochromocytoma (MPC)-mCherry allograft model showed high tumor densities of murine SSTR2 (mSSTR2) and high tumor uptake of [64Cu]Cu-DOTATATE. Using tumor sections, we assessed mSSTR2-specific binding of DOTATATE, AN-238, and somatostatin-14. Therapeutic studies showed substantial reduction of tumor growth and tumor-related renal monoamine excretion in tumor-bearing mice after treatment with [177Lu]Lu-DOTATATE compared to AN-238 and doxorubicin. Analyses did not show agonist-dependent receptor downregulation after single mSSTR2-targeting therapies. This study demonstrates that the MPC-mCherry model is a uniquely powerful tool for the preclinical evaluation of SSTR2-targeting theranostic applications in vivo. Our findings highlight the therapeutic potential of somatostatin analogs, especially of [177Lu]Lu-DOTATATE, for the treatment of metastatic PHEO/PGLs. Repeated treatment cycles, fractionated combinations of SSTR2-targeting radionuclide and cytotoxic therapies, and other adjuvant compounds addressing additional mechanisms may further enhance therapeutic outcome. PMID:27022413

  8. Multimodal Somatostatin Receptor Theranostics Using [(64)Cu]Cu-/[(177)Lu]Lu-DOTA-(Tyr(3))octreotate and AN-238 in a Mouse Pheochromocytoma Model.

    PubMed

    Ullrich, Martin; Bergmann, Ralf; Peitzsch, Mirko; Zenker, Erik F; Cartellieri, Marc; Bachmann, Michael; Ehrhart-Bornstein, Monika; Block, Norman L; Schally, Andrew V; Eisenhofer, Graeme; Bornstein, Stefan R; Pietzsch, Jens; Ziegler, Christian G

    2016-01-01

    Pheochromocytomas and extra-adrenal paragangliomas (PHEO/PGLs) are rare catecholamine-producing chromaffin cell tumors. For metastatic disease, no effective therapy is available. Overexpression of somatostatin type 2 receptors (SSTR2) in PHEO/PGLs promotes interest in applying therapies using somatostatin analogs linked to radionuclides and/or cytotoxic compounds, such as [(177)Lu]Lu-DOTA-(Tyr(3))octreotate (DOTATATE) and AN-238. Systematic evaluation of such therapies for the treatment of PHEO/PGLs requires sophisticated animal models. In this study, the mouse pheochromocytoma (MPC)-mCherry allograft model showed high tumor densities of murine SSTR2 (mSSTR2) and high tumor uptake of [(64)Cu]Cu-DOTATATE. Using tumor sections, we assessed mSSTR2-specific binding of DOTATATE, AN-238, and somatostatin-14. Therapeutic studies showed substantial reduction of tumor growth and tumor-related renal monoamine excretion in tumor-bearing mice after treatment with [(177)Lu]Lu-DOTATATE compared to AN-238 and doxorubicin. Analyses did not show agonist-dependent receptor downregulation after single mSSTR2-targeting therapies. This study demonstrates that the MPC-mCherry model is a uniquely powerful tool for the preclinical evaluation of SSTR2-targeting theranostic applications in vivo. Our findings highlight the therapeutic potential of somatostatin analogs, especially of [(177)Lu]Lu-DOTATATE, for the treatment of metastatic PHEO/PGLs. Repeated treatment cycles, fractionated combinations of SSTR2-targeting radionuclide and cytotoxic therapies, and other adjuvant compounds addressing additional mechanisms may further enhance therapeutic outcome.

  9. Isomeric ratio measurements for the radiative neutron capture 176Lu(n,γ) at DANCE

    NASA Astrophysics Data System (ADS)

    Denis-Petit, D.; Roig, O.; Méot, V.; Jandel, M.; Vieira, D. J.; Bond, E. M.; Bredeweg, T. A.; Couture, A. J.; Haight, R. C.; Keksis, A. L.; Rundberg, R. S.; Ullmann, J. L.

    2016-03-01

    The isomeric ratio for the neutron capture reaction 176Lu(n,γ) on the Jπ= 5/2-, 761.7 keV, T1/2=32.8 ns level of 177mLu, has been determined in the neutron energy range 8.5 eV-100 keV for the first time using the DANCE array at the Los Alamos National Laboratory.

  10. In Vivo Measurement and Characterization of a Novel Formulation of [177Lu]-DOTA-Octreotate

    PubMed Central

    Bailey, Dale L; Hennessy, Thomas M; Willowson, Kathy P; Henry, E Courtney; Chan, David LH; Aslani, Alireza; Roach, Paul J

    2016-01-01

    Objective(s): Lutetium-177 can be made with high specific activity and with no other isotopes of lutetium present, referred to as “No Carrier Added” (NCA) 177Lu. We have radiolabelled DOTA-conjugated peptide DOTA-(Tyr3)-octreotate with NCA 177Lu (“NCA-LuTATE”) and used it in nearly 40 therapeutic administrations for subjects with neuroendocrine tumours or meningiomas. In this paper, we report on our initial studies on aspects of the biodistribution and dosimetry of NCA-LuTATE from gamma camera 2D whole body (WB) and quantitative 3D SPECT (qSPECT) 177Lu imaging. Methods: Thirteen patients received 39 NCA-LuTATE injections. Extensive WB planar and qSPECT imaging was acquired at approximately 0.5, 4, 24 and 96 h to permit estimates of clearance and radiation dose estimation using MIRD-based methodology (OLINDA-EXM). Results: The average amount of NCA-Lutate administered per cycle was 7839±520 MBq. Bi-exponential modelling of whole body clearance showed half lives for the fast & slow components of t½=2.1±0.6 h and t½=58.1±6.6 h respectively. The average effective dose to kidneys was 3.1±1.0 Gy per cycle. In eight patients completing all treatment cycles the average total dose to kidneys was 11.7±3.6 Gy. Conclusions: We have shown that NCA-LuTATE has an acceptable radiation safety profile and is a suitable alternative to Carrier-Added 177Lu formulations. The fast component of the radiopharmaceutical clearance was closely correlated with baseline renal glomerular filtration rate, and this had an impact on radiation dose to the kidneys. In addition, it has less radioactive waste issues and requires less peptide per treatment. PMID:27904871

  11. Tumoral fibrosis effect on the radiation absorbed dose of (177)Lu-Tyr(3)-octreotate and (177)Lu-Tyr(3)-octreotate conjugated to gold nanoparticles.

    PubMed

    Azorín-Vega, E P; Zambrano-Ramírez, O D; Rojas-Calderón, E L; Ocampo-García, B E; Ferro-Flores, G

    2015-06-01

    The aim of this work was to evaluate the tumoral fibrosis effect on the radiation absorbed dose of the radiopharmaceuticals (177)Lu-Tyr(3)-octreotate (monomeric) and (177)Lu-Tyr(3)-octreotate-gold nanoparticles (multimeric) using an experimental HeLa cells tumoral model and the Monte Carlo PENELOPE code. Experimental and computer micro-environment models with or without fibrosis were constructed. Results showed that fibrosis increases up to 33% the tumor radiation absorbed dose, although the major effect on the dose was produced by the type of radiopharmaceutical (112Gy-multimeric vs. 43Gy-monomeric).

  12. BIPM comparison BIPM.RI(II)-K1.Lu-177 of activity measurements of the radionuclide 177Lu for the NPL (UK) and the IRMM (EU), with linked results for the comparison CCRI(II)-K2.Lu-177

    NASA Astrophysics Data System (ADS)

    Michotte, C.; Ratel, G.; Courte, S.; Johansson, L.; Keightley, J.; Arinc, A.; Bakhshandeiar, E.; Pommé, S.; Altzitzoglou, T.; Paepen, J.; Van Ammel, R.

    2014-01-01

    Two new participations in the comparison BIPM.RI(II)-K1.Lu-177 have been added to the previous results and this has produced a revised value for the key comparison reference value (KCRV), calculated using the power-moderated weighted mean. A link has been made to the comparison CCRI(II)-K2.Lu-177 held in 2009 through the NPL and IRMM who participated in both comparisons. Two NMIs used the K2 comparison to update their degree of equivalence. The degrees of equivalence between each equivalent activity measured in the International Reference System (SIR) and the KCRV have been calculated and the results are given in the form of a table for the remaining two NMIs in the comparison BIPM.RI(II)-K1.Lu-177 and the nine other participants in the comparison CCRI(II)-K2.Lu-177. A graphical presentation is also given. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  13. Energy enhancement of mixed Nd:LuYSGG crystal in passively Q-switched lasers.

    PubMed

    Wang, Baolin; Tian, Li; Yu, Haohai; Zhang, Huaijin; Wang, Jiyang

    2015-07-01

    The continuous-wave (cw) and passively Q-switched laser performances of mixed Nd:Lu(2)YSc(1.5)Ga(3.5)O(12) (Nd:LuYSGG) crystal at 1.06 μm were reported for the first time. The cw output power reached 4.39 W at the absorbed pump power of 10.34 W with slope efficiency of 48.0%. With a Cr(4+):YAG crystal as both the saturable absorber and output coupler, a passively Q-switched laser was realized with the maximum average output power of 1.43 W and slope efficiency of 21.0%. The shortest pulse width, largest pulse energy, and highest peak power were 4.1 ns, 157.1 μJ, and 38.3 kW, respectively. Compared with Nd:Lu(3)Sc(1.5)Ga(3.5)O(12) (Nd:LuSGG) crystal, the pulse energy and peak power are enhanced over more than two times for Nd:LuYSGG. The results show that Nd:LuYSGG crystal is a promising laser material with large energy storage capacities and suitable for the application of pulsed lasers with shorter pulses and larger energies.

  14. Complex cytokine modulation of a continuous line of mink lung epithelial cells (Mv1Lu).

    PubMed

    Kelley, J; Baldor, L; Absher, M

    1992-01-01

    The continuous mink lung epithelial cell line Mv1Lu has proven to be a sensitive reporter line in the bioassay for purified TGF-beta, exhibiting a sigmoid-shaped concentration-response relationship with an EC50 of 12 pM (0.3 ng/mL). Maximal inhibition of Mv1Lu cells generates a 75-95% decrement in the number of adherent cells. However, this bioassay is not specific for TGF-beta as originally claimed. Mv1Lu cells are sensitive to other cytokines and substances found in complex biological fluids. In this study the effects of other biological response modifiers in this assay were tested and several were found to have important growth modulatory capacities that confound the quantitation of TGF-beta. EGF, TGF-alpha, fibronectin, and IGF-I all induce Mv1Lu cell proliferation. In contrast, neither PDGF (-AA, -AB, -BB) nor endotoxin (< or = 10 micrograms/mL) affect Mv1Lu cell number. TGF-beta and TNF-alpha at high concentrations (> or = 10 ng/mL) are the only cytokines examined that inhibit Mv1Lu proliferation. TGF-beta decreases final cell number both by preventing mitosis and by inhibition of adherence of cells to the uncoated dish. Several strategies are suggested to assure the specificity of this otherwise convenient bioassay for TGF-beta.

  15. Acceleration on stretched meshes with line-implicit LU-SGS in parallel implementation

    NASA Astrophysics Data System (ADS)

    Otero, Evelyn; Eliasson, Peter

    2015-02-01

    The implicit lower-upper symmetric Gauss-Seidel (LU-SGS) solver is combined with the line-implicit technique to improve convergence on the very anisotropic grids necessary for resolving the boundary layers. The computational fluid dynamics code used is Edge, a Navier-Stokes flow solver for unstructured grids based on a dual grid and edge-based formulation. Multigrid acceleration is applied with the intention to accelerate the convergence to steady state. LU-SGS works in parallel and gives better linear scaling with respect to the number of processors, than the explicit scheme. The ordering techniques investigated have shown that node numbering does influence the convergence and that the orderings from Delaunay and advancing front generation were among the best tested. 2D Reynolds-averaged Navier-Stokes computations have clearly shown the strong efficiency of our novel approach line-implicit LU-SGS which is four times faster than implicit LU-SGS and line-implicit Runge-Kutta. Implicit LU-SGS for Euler and line-implicit LU-SGS for Reynolds-averaged Navier-Stokes are at least twice faster than explicit and line-implicit Runge-Kutta, respectively, for 2D and 3D cases. For 3D Reynolds-averaged Navier-Stokes, multigrid did not accelerate the convergence and therefore may not be needed.

  16. Resistive switching behavior in Lu2O3 thin film for advanced flexible memory applications

    PubMed Central

    2014-01-01

    In this article, the resistive switching (RS) behaviors in Lu2O3 thin film for advanced flexible nonvolatile memory applications are investigated. Amorphous Lu2O3 thin films with a thickness of 20 nm were deposited at room temperature by radio-frequency magnetron sputtering on flexible polyethylene terephthalate substrate. The structural and morphological changes of the Lu2O3 thin film were characterized by x-ray diffraction, atomic force microscopy, and x-ray photoelectron spectroscopy analyses. The Ru/Lu2O3/ITO flexible memory device shows promising RS behavior with low-voltage operation and small distribution of switching parameters. The dominant switching current conduction mechanism in the Lu2O3 thin film was determined as bulk-controlled space-charge-limited-current with activation energy of traps of 0.33 eV. The oxygen vacancies assisted filament conduction model was described for RS behavior in Lu2O3 thin film. The memory reliability characteristics of switching endurance, data retention, good flexibility, and mechanical endurance show promising applications in future advanced memory. PMID:24387704

  17. Comparative vectorial efficiency of Lutzomyia evansi and Lu. longipalpis for transmitting Leishmania chagasi.

    PubMed

    Montoya-Lerma, J; Cadena, H; Oviedo, M; Ready, P D; Barazarte, R; Travi, B L; Lane, R P

    2003-01-01

    The infection rates and development of Leishmania chagasi in two sandfly species, Lutzomyia evansi and Lutzomyia longipalpis, were evaluated under natural and experimental conditions. Natural infection rates of Lu. evansi in San Andrés de Sotavento (Colombia) and Montañas de Peraza (Venezuela) (0.05 and 0.2%, respectively) were similar to those previously recorded for this species in Colombia and Venezuela and for Lu. longipalpis in many foci of American Visceral Leishmaniasis (AVL). Both sand fly species were able to support the development of two Colombian strains of L. chagasi experimentally acquired from dogs, hamsters or membrane feeders. However, the experimental infection rates and the sequence of parasite development in the guts of these sand flies revealed that parasite colonisation, differentiation, migration and attachment were more frequent and uniform in Lu. longipalpis than in Lu. evansi. This is consistent with a more recent association between L. chagasi and Lu. evansi, and these results might help to explain the irregularity of AVL outbreaks in foci where Lu. evansi has been reported as the sole vector.

  18. Lutetium texaphyrin (Lu-Tex): a potential new agent for ocular fundus angiography and photodynamic therapy.

    PubMed

    Blumenkranz, M S; Woodburn, K W; Qing, F; Verdooner, S; Kessel, D; Miller, R

    2000-03-01

    To investigate the suitability of lutetium texaphyrin (lu-tex) as a fluorescence imaging agent in the delineation of retinal vascular and choroidal vascular diseases. The utilization of an efficient fluorescent molecule that is also a photosensitizer represents a unique opportunity to couple diagnosis and therapy. Fundus fluorescence angiography comparing lu-tex (motexafin lutetium, Optrin, Pharmacyclics Inc, Sunnyvale, California) with the conventional angiographic dyes, sodium fluorescein, and indocynanine green (ICG), was performed on the eyes of normal and laser-injured New Zealand white rabbits. Plasma pharmacokinetic data and plasma protein binding were assessed in addition to light microscopy of the retina in both imaged and laser-injured eyes. Normal retinal and choroidal vasculature was well delineated by lu-tex angiography. Experimentally induced choroidal and retinal vascular lesions were enhanced by lu-tex and demonstrated different staining patterns than fluorescein or ICG, particularly at the margins of the lesions. Lu-tex cleared rapidly from the plasma, with 39.7% bound to the high-density lipoprotein (HDL) fraction while 15.8% was bound to the low-density lipoprotein (LDL) fraction. No evidence of retinal toxicity after dye administration was observed by either ophthalmoscopy and fundus photography or by light microscopy. Lu-tex angiography is a potentially valuable method for retinal vascular and choroidal vascular evaluation, and it has advantages over fluorescein and ICG angiography. The same agent could conceivably be used for both the identification of abnormal vasculature and subsequent photodynamic treatment.

  19. Correlation between magnon and magnetic symmetries of hexagonal RMnO3 (R = Er, Ho, Lu)

    NASA Astrophysics Data System (ADS)

    Nguyen, Thi Minh Hien; Nguyen, Thi Huyen; Chen, Xiang-Bai; Park, Yeonju; Jung, Young Mee; Lee, D.; Noh, T. W.; Cheong, Sang-Wook; Yang, In-Sang

    2016-11-01

    The correlation between the magnon scattering and the magnetic symmetries of hexagonal RMnO3 (R = Er, Ho) thin films and LuMnO3 single crystal was studied through the 2D Correlation Spectroscopy (2D COS) and Perturbation-Correlation Moving Window 2D (PCMW2D) Correlation Spectroscopy which were performed on the temperature-dependent Raman spectra of RMnO3 (R = Er, Ho, Lu). From the Raman spectra, we observed much stronger intensity and more asymmetrical magnon peak in LuMnO3 single crystal than in ErMnO3 and HoMnO3 thin films. While the ratio between magnon and phonon's linewidth of LuMnO3 and HoMnO3 display an anomalous behavior, that ratio of ErMnO3 is almost stable. The result from PCMW2D also supports these results. In addition, our 2D COS analysis showed that there are more overlap peaks in broad four-spin flipping magnon peak in LuMnO3 than that in ErMnO3 and HoMnO3. The differences of hexagonal RMnO3 (R = Er, Ho, Lu) in magnon scattering are very similar to the actual differences of the magnetic symmetries of these compounds. Therefore, we suggest that the magnon scattering of hexagonal RMnO3 is strongly correlated with the magnetic symmetries of these materials.

  20. Comparison of structural and electrical properties of Lu2O3 and Lu2TiO5 gate dielectrics for α-InGaZnO thin-film transistors

    NASA Astrophysics Data System (ADS)

    Pan, Tung-Ming; Chen, Ching-Hung; Her, Jim-Long; Koyama, Keiichi

    2014-11-01

    We compared the structural properties and electrical characteristics of high-κ Lu2O3 and Lu2TiO5 gate dielectrics for amorphous indium-gallium-zinc oxide (α-InGaZnO) thin-film transistor (TFT) applications. The Lu2O3 film has a strong Lu2O3 (400) peak in the X-ray diffraction pattern, while the Lu2TiO5 sample shows a relatively weak Lu2TiO5 (102) peak. Atomic force microscopy reveals that the Lu2O3 dielectric exhibits a rougher surface (about three times) than Lu2TiO5 one. In X-ray photoelectron spectroscopy analysis, we found that the intensity of the O 1s peak corresponding to Lu(OH)x for Lu2O3 film was higher than that of Lu2TiO5 film. Furthermore, compared with the Lu2O3 dielectric, the α-InGaZnO TFT using the Lu2TiO5 gate dielectric exhibited a lower threshold voltage (from 0.43 to 0.25 V), a higher Ion/Ioff current ratio (from 3.5 × 106 to 1.3 × 108), a smaller subthreshold swing (from 276 to 130 mV/decade), and a larger field-effect mobility (from 14.5 to 24.4 cm2/V s). These results are probably due to the incorporation of TiOx into the Lu2O3 film to form a Lu2TiO5 structure featuring a smooth surface, a low moisture absorption, a high dielectric constant, and a low interface state density at the oxide/channel interface. Furthermore, the stability of Lu2O3 and Lu2TiO5 α-InGaZnO TFTs was investigated under positive gate-bias stress (PGBS) and negative gate-bias stress (NGBS). The threshold voltage of the TFT performed under NGBS is more degradation than that under PGBS. This behavior may be attributed to the electron charge trapping at the dielectric-channel interface under PGBS, whereas the oxygen vacancies occurred in the InGaZnO under NGBS.

  1. Effects of Bu-Shen-Ning-Xin Decoction on immune cells of the spleen and bone marrow in ovariectomized mice.

    PubMed

    Qiu, Xuemin; Gui, Yuyan; Zhang, Na; Xu, Yingping; Li, Dajin; Wang, Ling

    2016-11-15

    Osteoimmunology is a new discipline that focuses on the interaction between the bones and the immune system. Immune cells play an important role in bone metabolism. The aim of this study was to illustrate the effect of Bu-Shen-Ning-Xin Decoction (BSNXD) on lymphocytes in the spleen and bone marrow to explore the potential role on the bone. C57BL/6 mice were divided into four groups: sham, ovariectomized (OVX), OVX+BSNXD, and OVX+ estrogen. The sham and OVX groups were treated with saline, the OVX+BSNXD group was treated with BSNXD, and the OVX+ estrogen group was treated with estrogen. After mice were sacrificed, the spleens and bones were collected, and the lymphocytes in the spleen and bone marrow were analyzed. We found that BSNXD lessened the extent of the increase of CD4(+) and bone marrow. In contrast, these numbers were both increased in the OVX group. BSNXD had no influence on the percentage of γδ T cells. However, it increased the proportion of NK cells in the spleen and bone marrow. BSNXD lessened the extent of the increase of monocytes by ovariectomy. In vitro experiment, we found Tregs can decrease osteoclastogenesis when co-cultured with osteoclast precursor cells. This study suggests that BSNXD changes the immune environment and immune cells have a role in bone metabolism in OVX mice.

  2. Effects of ning shen ling granule and dehydroepiandrosterone on cognitive function in mice undergoing chronic mild stress.

    PubMed

    Zhang, Xiao; Dong, Yi-long; Yang, Nan; Liu, Yan-yong; Gao, Rui-feng; Zuo, Ping-ping

    2007-03-01

    To investigate the changes of spontaneous and cognitive behavior, and cholinergic M receptors in the brain of mice subjected to chronic mild stress (CMS), and to determine the effect of Ning Shen Ling Granule (NSL) and dehydroepiandrosterone (DHEA) on them. CMS model mice were established by applying stress every day for 3 consecutive weeks with 7 kinds of unforeseeable stress sources, and they were medicated for 1 week beginning at the 3rd week of modeling. The changes in behavior were determined by Morris Water Maze and spontaneous movement test, and M-receptor binding activity in cerebral cortex, hippocampus and hypothalamus were measured by radioactive ligand assay with 3H-QNB. (1) The spontaneous movement in CMS model mice was significantly reduced, with the latency for searching platform in Morris Water Maze obviously prolonged (P<0.01), and these abnormal changes in behavior were improved in those treated with NSL and DHEA. (2) The binding ability of M-receptor in cerebral cortex and hippocampus of CMS mice was significantly decreased as compared with those in the control group (P<0.05), but could be restored to the normal level after intervention with NSL or DHEA. The decline of spontaneous movement and spatial learning and memory ability could be induced in animals by chronic mild stress, and that may be related to the low activity of central cholinergic M-receptors. Both NSL and DHEA could effectively alleviate the above-mentioned changes.

  3. Research on the change of chemical composition in productive process of Re Du Ning injection by HPLC/Q-TOF MS.

    PubMed

    Zhang, Shan; Li, Yan-Jing; Zhang, Chun-Xiao; Huang, Wen-Zhe; Ding, Gang; Wang, Zhen-Zhong; Bi, Yu-An; Xiao, Wei

    2016-02-01

    A high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) was developed for the analysis of chemical composition change in the production process of Re Du Ning injection, a Chinese medicine preparation with a combination of Lonicera japonica Thunb., Gardenia jasminoides Ellis and Artemisia annua L. A total of 90 compounds from raw materials-intermediates-Re Du Ning injection were detected; among them, 55 compounds were identified or tentatively characterized, and the characteristic ions of different types of compounds were described. Based on these studies, the different types of compounds in the various process routes were analyzed. A total of 28 compounds, including seven iridoid glycosides and six monoterpenes from G. jasminoides Ellis, five iridoid glycosides, nine phenolic acids and one unknown compound from L. japonica Thunb., were transferred to Re Du Ning injection, and two unknown compounds were generated in the production process of Re Du Ning injection. The results indicated that the Chinese Medicine Pharmaceutical process control is very important. This method could provide some reference for other Chinese medicine preparations.

  4. LU-HF Age of Martian Meteorite Larkman Nunatek 06319

    NASA Technical Reports Server (NTRS)

    Shafer, J. T.; Brandon, A. D.; Lapen, T. J.; Righter, M.; Beard, B.; Peslier, A. H.

    2009-01-01

    Lu-Hf isotopic data were collected on mineral separates and bulk rock powders of LAR 06319, yielding an age of 197+/- 29 Ma. Sm-Nd isotopic data and in-situ LA-ICP-MS data from a thin section of LAR 06319 are currently being collected and will be presented at the 2009 LPSC. These new data for LAR 06319 extend the existing data set for the enriched shergottite group. Martian meteorites represent the only opportunity for ground truth investigation of the geochemistry of Mars [1]. At present, approximately 80 meteorites have been classified as Martian based on young ages and distinctive isotopic signatures [2]. LAR 06319 is a newly discovered (as part of the 2006 ANSMET field season) martian meteorite that represents an important opportunity to further our understanding of the geochemical and petrological constraints on the origin of Martian magmas. Martian meteorites are traditionally categorized into the shergottite, nakhlite, and chassignite groups. The shergottites are further classified into three distinct isotopic groups designated depleted, intermediate, and enriched [3,4] based on the isotope systematics and compositions of their source(s).

  5. Physical optimization of production by deuteron irradiation of high specific activity (177g)Lu suitable for radioimmunotherapy.

    PubMed

    Manenti, Simone; Bonardi, Mauro L; Gini, Luigi; Groppi, Flavia

    2014-01-01

    Deuteron-induced nuclear reactions for generation of no-carrier-added (NCA) Lu isotopes were investigated using the stacked-foil activation technique on natural Yb targets at energies up to Ed=18.18MeV. The decay curve of ¹⁷⁷Yb, the growth curve of the cumulative (direct and indirect) and the direct production of (177g)Lu were determined. The analysis of these curves conducts to the evidence that the predominant route for the production of (177g)Lu is the indirect reaction ¹⁷⁶Yb(d,p)¹⁷⁷Yb, which decays to (177g)Lu. In the spectra acquired one year from the EOB the γ lines of (177m)Lu are not evident. A comparison between the calculated activity of (177g)Lu produced with a cyclotron and with a nuclear reactor is given. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Microstructure, optical, and scintillation characteristics of Pr3+ doped Lu3Al5O12 optical ceramics

    NASA Astrophysics Data System (ADS)

    Shi, Yun; Nikl, Martin; Feng, Xiqi; Mares, Jiri A.; Shen, Yiqiang; Beitlerova, A.; Kucerkova, R.; Pan, Yubai; Liu, Qian

    2011-01-01

    0.5, 1.0, and 5.0 at. % Pr3+ doped Lu3Al5O12 (Pr:LuAG) optical ceramics are fabricated and compared with Bi4Ge3O12 (BGO) and Pr:LuAG single crystals as for their optical, luminescence and scintillation properties. Radio-luminescence intensity of the fast UV emission based on 5d1→4f Pr3+ transition reaches up to 20 times of that of BGO single crystal reference scintillator. Photoelectron yield of the best performing 0.5 at. % Pr:LuAG ceramic sample is about 1002 phels/MeV, about 30% lower than that of BGO reference sample and about 65% lower than that of Pr:LuAG single crystal. The trapping phenomena at grain boundaries and/or structural defects are proposed as the main cause of degradation of the scintillation response of the Pr:LuAG optical ceramics.

  7. Non-magnetic and magnetic impurity effects on superconductivity in the ternary iron-silicide Lu2FeSi

    NASA Astrophysics Data System (ADS)

    Watanabe, Tadataka; Okuyama, Hiroaki; Takase, Kouichi; Takano, Yoshiki

    2010-12-01

    We studied effect of non-magnetic and magnetic impurities on superconductivity in LuFeSi by investigating superconducting properties of (LuFeSi (R=Sc,Y, and Dy). The rapid depression of Tc by non-magnetic impurities reveals strong pair breaking by disorder, providing compelling evidence for the sign reversal of the superconducting order parameter in LuFeSi.

  8. Time-resolved spectroscopy of intrinsic luminescence of Y 3Ga 5O 12 and (LaLu) 3Lu 2Ga 3O 12 single crystals

    NASA Astrophysics Data System (ADS)

    Zorenko, Yu.; Zorenko, T.; Vistovskyy, V.; Grinberg, M.; Łukasiewicz, T.

    2009-10-01

    The nature of intrinsic luminescence of Y 3Ga 5O 12 (YGG) and (LaLu) 3Lu 2Ga 3O 12 (LLGG) single crystals grown from a melt was determined. In the case of a YGG single crystal containing Y Ga antisite defects with a concentration of 0.25-0.275 at.% the intrinsic luminescence was considered as a superposition of luminescence of self-trapped excitons (STE), luminescence of excitons localized near antisite defects (LE(AD) centers) and luminescence caused by a recombination of an electron with a hole captured at Y Ga antisite defects. Due to a large (2-3%) concentration of Lu La antisite defects in LLGG single crystals the intrinsic luminescence was a superposition mainly of the LE(AD) center emission and the recombination luminescence of Lu La antisite defects. The energy structure of the mentioned centers in YGG and LGGG hosts was determined from the excitation spectra of their luminescence under excitation by synchrotron radiation in the range of the fundamental absorption edge of these garnets.

  9. Growth and luminescent properties of Lu2SiO5 and Lu2SiO5:Ce single crystalline films

    NASA Astrophysics Data System (ADS)

    Zorenko, Yu; Nikl, M.; Gorbenko, V.; Mares, J. A.; Savchyn, V.; Voznyak, T.; Solsky, I.; Grynyov, B.; Sidletskiy, O.; Kurtsev, D.; Beitlerova, A.; Kucerkova, R.

    2010-11-01

    Single crystalline films (SCF) of Lu2SiO5 (LSO) and Lu2SiO5:Ce (LSO:Ce) silicates with thickness of 2.5-21 μm were crystallised by liquid phase epitaxy method onto undoped LSO substrates from melt-solution based on PbO-B2O3 flux. The luminescence and scintillation properties of LSO and LSO:Ce SCFs were compared with the properties of a reference LSO:Ce and LYSO:Ce crystals. The light yield (LY) of LSO and LSO:Ce SCF reaches up 30 % and 145 %, respectively, of that of a reference LSO:Ce crystal under excitation by α-particles of 241Am source (5.5 MeV). We found that the luminescence spectrum of LSO:Ce SCF is red-shifted with respect to the spectrum of a reference LSO:Ce crystal. Differences in luminescence properties of LSO:Ce SCF and single crystal are explained by the different distribution of Ce3+ over the Lu1 and Lu2 positions of LSO host and are also due to Pb2+ contamination in the former.

  10. A potencial theranostic agent for EGF-R expression tumors: (177)Lu-DOTA-nimotuzumab.

    PubMed

    Calzada, Victoria; Zhang, Xiuli; Fernandez, Marcelo; Diaz-Miqueli, Arlhee; Iznaga-Escobar, Normando; Deutscher, Susan L; Balter, Henia; Quinn, Thomas P; Cabral, Pablo

    2012-10-01

    In this work Nimotuzumab (monoclonal antibody, recognizes the EGF-R) was radiolabeled with (177)Lu as a potential cancer therapy radiopharmaceutical. In-vitro cell binding studies and in-vivo biodistribution and imaging studies were performed to determine the radiochemical stability, targeting specificity and pharmacokinetics of the (177)Lu-labeled antibody. Nimotuzumab was derivatized with DOTA-NHS at room temperature for 2 hours. DOTA-Nimotuzumab was radiolabeled with (177)LuCl3 (15 MBq/mg) at 37°C for 1 h. The radiochemical purity was assessed by ITLC, silica gel and by RP-HPLC. Binding specificity studies were performed with EGF-R positive A431 human epithelial carcinoma and EGF-R negative MDA-MB-435 breast carcinoma cells. Biodistribution studies were performed in healthy female CD-1 mice at 1 h, 4 h, 24 h, and A431 xenografted nude mice at 10 min, 1 h, 4 h, 24 h, 48 h, and 96 h. SPECT-CT imaging studies were performed in A431 xenografted mice at 24 h post injection. DOTA-Nimotuzumab was efficiently labeled with (177) LuCl(3) at 37°C. The in vitro stability of labeled product was optimal over 24 h in buffered saline and mouse serum. Specific recognition of EGF-R by (177)Lu-DOTA-Nimotuzumab was observed in A431 cell binding studies. Biodistribution studies demonstrated increasing tumor uptake of (177)Lu-DOTA-Nimotuzumab over time, with tumor to muscle ratios of 6.26, 10.68, and 18.82 at 4 h, 24 h, and 96 h post injection. Imaging of A431 xenografted mice showed high uptake in the tumor. (177)Lu-DOTA-Nimotuzumab has the potential to be a promising therapy agent, which may be useful in the treatment of patients with EGF-R positive cancer.

  11. Polymorphism, phase transitions, and thermal expansion of K3Lu(PO4)2

    SciTech Connect

    Farmer, James Matthew; Boatner, Lynn A; Chakoumakos, Bryan C; Rawn, Claudia J.; Mandrus, D.; Bryan, Jeff C.

    2014-01-01

    Alkali rare-earth double phosphates have been studied for use as long-wavelength scintillators for -ray detection using Si photodiodes. Single-crystal and powder x-ray diffraction (XRD) and powder neutron diffraction have been used to study the structure as a function of temperature. K3Lu(PO4)2 crystallizes with a hexagonal unit cell at room temperature, space group P 3. The Lu ion is six-coordinated to the oxygen atoms of the phosphate groups. Two lower-temperature phases were characterized using single-crystal XRD and powder neutron diffraction. The first transition occurs at 230 K with a transformation to a monoclinic P21/m space group symmetry, and the Lu retains six coordination. The second phase transition occurs at 130 K, with a large change in the cell volume, keeping the same P21/m space group symmetry; however, one of the phosphate groups rotates to increase the coordination of the Lu ion to seven. This is an unusual example of an isosymmetric phase transition with a coordination change, driven by temperature. High-temperature powder neutron diffraction and high-temperature powder XRD have been used to study the thermal expansion of K3Lu(PO4)2 and indicate a large thermal expansion anisotropy. The crystallographic axes with largest changes account for the structural collapse, which rotates the phosphate group to increase the Lu coordination. The lowest temperature form of K3Lu(PO4)2 is the same as the room temperature form for all the lighter RE compounds of the same type, which is not surprising, given the lighter (larger) RE ions would prefer a higher coordination number.

  12. Specific radioactivity of neutron induced radioisotopes: assessment methods and application for medically useful 177Lu production as a case.

    PubMed

    Le, Van So

    2011-01-19

    The conventional reaction yield evaluation for radioisotope production is not sufficient to set up the optimal conditions for producing radionuclide products of the desired radiochemical quality. Alternatively, the specific radioactivity (SA) assessment, dealing with the relationship between the affecting factors and the inherent properties of the target and impurities, offers a way to optimally perform the irradiation for production of the best quality radioisotopes for various applications, especially for targeting radiopharmaceutical preparation. Neutron-capture characteristics, target impurity, side nuclear reactions, target burn-up and post-irradiation processing/cooling time are the main parameters affecting the SA of the radioisotope product. These parameters have been incorporated into the format of mathematical equations for the reaction yield and SA assessment. As a method demonstration, the SA assessment of 177Lu produced based on two different reactions, 176Lu (n,γ)177Lu and 176Yb (n,γ) 177Yb (β- decay) 177Lu, were performed. The irradiation time required for achieving a maximum yield and maximum SA value was evaluated for production based on the 176Lu (n,γ)177Lu reaction. The effect of several factors (such as elemental Lu and isotopic impurities) on the 177Lu SA degradation was evaluated for production based on the 176Yb (n,γ) 177Yb (β- decay) 177Lu reaction. The method of SA assessment of a mixture of several radioactive sources was developed for the radioisotope produced in a reactor from different targets.

  13. Effective lattice stabilization of gadolinium aluminate garnet (GdAG) via Lu3+ doping and development of highly efficient (Gd,Lu)AG:Eu3+ red phosphors

    PubMed Central

    Li, Jinkai; Li, Ji-Guang; Zhang, Zhongjie; Wu, Xiaoli; Liu, Shaohong; Li, Xiaodong; Sun, Xudong; Sakka, Yoshio

    2012-01-01

    The metastable garnet lattice of Gd3Al5O12 is stabilized by doping with smaller Lu3+, which then allows an effective incorporation of larger Eu3+ activators. The [(Gd1−xLux)1−yEuy]3Al5O12 (x = 0.1–0.5, y = 0.01–0.09) garnet solid solutions, calcined from their precursors synthesized via carbonate coprecipitation, exhibit strong luminescence at 591 nm (the 5D0 → 7F1 magnetic dipole transition of Eu3+) upon UV excitation into the charge transfer band (CTB) at ∼239 nm, with CIE chromaticity coordinates of x = 0.620 and y = 0.380 (orange-red). The quenching concentration of Eu3+ was estimated at ∼5 at.% (y = 0.05), and the quenching was attributed to exchange interactions. Partial replacement of Gd3+ with Lu3+ up to 50 at.% (x = 0.5) while keeping Eu3+ at the optimal content of 5 at.% does not significantly alter the peak positions of the CTB and 5D0 → 7F1 emission bands but slightly weakens both bands owing to the higher electronegativity of Lu3+. The effects of processing temperature (1000–1500 °C) and Lu/Eu contents on the intensity, quantum efficiency, lifetime and asymmetry factor of luminescence were thoroughly investigated. The [(Gd0.7Lu0.3)0.95Eu0.05]3Al5O12 phosphor processed at 1500 °C exhibits a high internal quantum efficiency of ∼83.2% under 239 nm excitation, which, in combination with the high theoretical density, favors its use as a new type of photoluminescent and scintillation material. PMID:27877495

  14. Growth and luminescent properties of Lu 2SiO 5:Ce and (Lu 1- xGd x) 2SiO 5:Ce single crystalline films

    NASA Astrophysics Data System (ADS)

    Zorenko, Yu.; Gorbenko, V.; Savchyn, V.; Voznyak, T.; Grinyov, B.; Sidletskiy, O.; Kurtsev, D.; Fedorov, A.; Baumer, V.; Nikl, M.; Mares, J. A.; Beitlerova, A.; Prusa, P.; Kucera, M.

    2011-12-01

    Single crystalline films (SCF) of Lu 2SiO 5:Ce (LSO:Ce), (Lu 1- xGd x) 2SiO 5:Ce (LGSO:Ce) and LGSO:Ce,Tb orthosilicates with thickness of 2.5-21 μm were crystallized by liquid phase epitaxy method onto undoped LSO substrates from melt-solution based on PbO-B 2O 3 flux. The concentration of Gd was varied in the range of x=0.2-0.7 formula units (f.u.). In the case of LGSO:Ce SCF growth we do not use any additional doping for reducing the misfit between the SCF and substrate lattices. The luminescence and scintillation properties of LSO:Ce, LGSO:Ce and LGSO:Ce,Tb SCFs were mutually compared and confronted with the performance of reference LSO:Ce and LYSO:Ce crystals. With increasing Gd content the luminescence spectrum of LGSO:Ce SCF is gradually red-shifted with respect to that of LSO:Ce SCF. The LY of (Lu 1- xGd x)SO:Ce SCF becomes lower in comparison with that for LSO:Ce SC at increasing Gd content in the range of x=0.2-0.7 f.u. The peculiarities of luminescence properties of LSO:Ce and LGSO:Ce SCFs in comparison with crystal analogs are explained by the different distribution of Ce 3+ over Lu1 and Lu2 positions of LSO host and by the influence of Pb 2+ contamination coming from the flux used for the film growth.

  15. IRon Overload screeNing tool (IRON): development of a tool to guide screening in primary care.

    PubMed

    Mainous, Arch G; Diaz, Vanessa A; Everett, Charles J; Knoll, Michele E; Hulihan, Mary M; Grant, Althea M; McLaren, Christine E; McLaren, Gordon D

    2011-09-01

    Iron overload is associated with significant morbidity and mortality yet is easily treated. The objective of this study was to create a tool that could be easily adapted to clinical practice that indicates the likelihood of a patient having undetected iron overload. We used the National Health and Nutrition Examination Survey (NHANES) 1999-2002 for US adults aged 20 years and older to build a model (unweighted n=8,779). We chose potential variables for inclusion that could be gathered by self-report or measured without laboratory data and were suggested by past literature on hemochromatosis and iron overload. We computed logistic regressions to create the scores by initially evaluating the variables' relationship with elevated ferritin and elevated transferrin saturation and then using odds ratios to correspond to scores. The resulting score on the IRon Overload ScreeNing Tool (IRON) was then validated with data on 13,844 adults in the NHANES III, 1988-94. Predictors in the final tool were age, gender, previous diagnoses of liver condition, osteoporosis or thyroid disease. The IRON score yielded an area under the curve (AUC) in the NHANES 1999-02 of 0.720 and an AUC of 0.685 in the NHANES III validation sample. The IRON score is a tool to assist in identification of patients with iron overload that has several qualities that make it attractive for use in clinical practice with an undifferentiated patient population including brevity, easily collected information and predictive ability comparable to other tools that help in directing screening. Copyright © 2011 Wiley-Liss, Inc.

  16. Sm-Nd and Lu-Hf isotope composition of chondritic components

    NASA Astrophysics Data System (ADS)

    Bouvier, A.; Vervoort, J. D.; Patchett, P. J.; Gopel, C.

    2009-12-01

    The 146Sm-142Nd, 147Sm-143Nd and 176Lu-176Hf radiogenic isotopic systems are widely used as chronometers and tracers of planetary evolution. These involve refractory lithophile elements and thus it is assumed that the average Sm-Nd and Lu-Hf composition of bulk terrestrial planets should be the same as that of chondrites (CHUR). We previously revised the CHUR compositions with 0.1960 ±0.0004 for 147Sm/144Nd and with 0.0336 ±0.0001 for 176Lu/177Hf using unequilibrated ordinary (OC) and carbonaceous (CC) chondrites [1], and proposed these should apply to the bulk silicate Earth (BSE). Recent studies suggest that BSE may have a super-chondritic Sm/Nd (~5%) and Lu/Hf (~10%) composition and could explain the Nd and Hf isotopic systematics of Earth and planetary materials [2, 3]. Here, we present additional Sm-Nd and Lu-Hf compositions of chondrites and chondritic components to evaluate potential isotopic heterogeneities present in the protoplanetary disk. Isotopic analyses were carried out by Neptune MC-ICPMS at ASU. Analytical details are in [1, 4]. We extend our study to homogenized whole-rock (WR) powders of 4 equilibrated OC to investigate the scale of Lu-Hf isotopic heterogeneities as consequences of thermal metamorphism on the OC parent bodies (PB) [1]. Their 147Sm/144Nd and 176Lu/177Hf vary from 0.1954 to 0.1969, and 0.0298 to 0.0341 respectively indicating that open metasomatism associated with crystallization of phosphate [1] occurred at least at the cm scale on the OCPB. We also present the first Lu-Hf and coupled Sm-Nd isotopic data of 6 single or pooled chondrules, and 2 calcium aluminum-rich inclusions (CAIs) from 5 type 3 OC & CC. The 147Sm/144Nd and 176Lu/177Hf ranges are 0.1956-0.1969, and 0.0331-0.0341 respectively for chondrules, and 0.1947-0.2147, and 0.0392-0.0501 respectively for CAIs. The chondrules are within the range of our earlier Sm/Nd and Lu/Hf CHUR-BSE estimates but the CAIs have significantly higher values, especially for Lu/Hf. Thus

  17. Phase 3 Trial of (177)Lu-Dotatate for Midgut Neuroendocrine Tumors.

    PubMed

    Strosberg, Jonathan; El-Haddad, Ghassan; Wolin, Edward; Hendifar, Andrew; Yao, James; Chasen, Beth; Mittra, Erik; Kunz, Pamela L; Kulke, Matthew H; Jacene, Heather; Bushnell, David; O'Dorisio, Thomas M; Baum, Richard P; Kulkarni, Harshad R; Caplin, Martyn; Lebtahi, Rachida; Hobday, Timothy; Delpassand, Ebrahim; Van Cutsem, Eric; Benson, Al; Srirajaskanthan, Rajaventhan; Pavel, Marianne; Mora, Jaime; Berlin, Jordan; Grande, Enrique; Reed, Nicholas; Seregni, Ettore; Öberg, Kjell; Lopera Sierra, Maribel; Santoro, Paola; Thevenet, Thomas; Erion, Jack L; Ruszniewski, Philippe; Kwekkeboom, Dik; Krenning, Eric

    2017-01-12

    Background Patients with advanced midgut neuroendocrine tumors who have had disease progression during first-line somatostatin analogue therapy have limited therapeutic options. This randomized, controlled trial evaluated the efficacy and safety of lutetium-177 ((177)Lu)-Dotatate in patients with advanced, progressive, somatostatin-receptor-positive midgut neuroendocrine tumors. Methods We randomly assigned 229 patients who had well-differentiated, metastatic midgut neuroendocrine tumors to receive either (177)Lu-Dotatate (116 patients) at a dose of 7.4 GBq every 8 weeks (four intravenous infusions, plus best supportive care including octreotide long-acting repeatable [LAR] administered intramuscularly at a dose of 30 mg) ((177)Lu-Dotatate group) or octreotide LAR alone (113 patients) administered intramuscularly at a dose of 60 mg every 4 weeks (control group). The primary end point was progression-free survival. Secondary end points included the objective response rate, overall survival, safety, and the side-effect profile. The final analysis of overall survival will be conducted in the future as specified in the protocol; a prespecified interim analysis of overall survival was conducted and is reported here. Results At the data-cutoff date for the primary analysis, the estimated rate of progression-free survival at month 20 was 65.2% (95% confidence interval [CI], 50.0 to 76.8) in the (177)Lu-Dotatate group and 10.8% (95% CI, 3.5 to 23.0) in the control group. The response rate was 18% in the (177)Lu-Dotatate group versus 3% in the control group (P<0.001). In the planned interim analysis of overall survival, 14 deaths occurred in the (177)Lu-Dotatate group and 26 in the control group (P=0.004). Grade 3 or 4 neutropenia, thrombocytopenia, and lymphopenia occurred in 1%, 2%, and 9%, respectively, of patients in the (177)Lu-Dotatate group as compared with no patients in the control group, with no evidence of renal toxic effects during the observed time frame

  18. Isotope effect in charge transport of LuB{sub 12}

    SciTech Connect

    Sluchanko, N. E. Azarevich, A. N.; Bogach, A. V.; Glushkov, V. V.; Demishev, S. V.; Kuznetsov, A. V.; Lyubshov, K. S.; Filippov, V. B.; Shitsevalova, N. Yu.

    2010-08-15

    The galvanomagnetic properties of single-crystal samples with various isotopic boron compositions have been investigated for the first time for the normal state of superconductor LuB{sub 12} (Tc {approx} 0.44 K). Precision measurements of the resistivity, Hall coefficient, and magnetic susceptibility have been performed over a wide temperature range of 2-300 K in magnetic fields up to 80 kOe. A change of the charge transport regime in this nonmagnetic compound with metallic conduction is shown to occur near T* {approx} 50-70 K. As a result, a sharp peak with significantly different amplitudes for Lu{sup 10}B{sub 12} and Lu{sup 11}B{sub 12} is recorded in the temperature dependences of the Hall coefficient R{sub H}(T) near T*. A significant (about 10%) difference (in absolute value) of the Hall coefficients R{sub H} for the Lu{sup 10}B{sub 12} and Lu{sup 11}B{sub 12} compounds at helium and intermediate temperatures has been found and the patterns of behavior of the dependence R{sub H}(H) for T < T* in an external magnetic field H {<=} 80 kOe for Lu{sup 10}B{sub 12} and Lu{sup 11}B{sub 12} are shown to differ significantly. Analysis of the Curie-Weiss contribution to the magnetic susceptibility {chi}(T) leads to the conclusion about the formation of magnetic moments {mu}{sub eff} {approx} (0.13-0.19){mu}{sub B} in each unit cell of the fcc structure of LuB{sub 12} compounds with various isotopic compositions. The possibility of the realization of an electronic topological 2.5-order transition near T* and the influence of correlation effects in the 5d-band on the formation of a spin polarization near the rare-earth ions in LuB{sub 12} is discussed.

  19. Synthesis and radiation tolerance of Lu2-xCexTi2O7 pyrochlores

    NASA Astrophysics Data System (ADS)

    Xia, Y.; Liu, C. G.; Yang, D. Y.; Wen, J.; Liu, H.; Mu, P. C.; Li, Y. H.

    2016-11-01

    As a nonradioactive surrogate for Pu, Ce is selected to study the solubility and radiation tolerance in pyrochlore matrixes. In this paper, we synthesized a series of Lu2-xCexTi2O7 (x = 0-0.7) samples. X-ray diffraction, X-ray photoelectron spectroscopy and Raman spectroscopy were used to study the structure of Lu2-xCexTi2O7 (x = 0-0.7) with different Ce3+ content x. The results show that the maximum solubility of Ce3+ in Lu2Ti2O7 is 32 mol%. In order to study the radiation tolerance of these compounds, 400 keV Ne2+ was used to perform the irradiation experiments. The grazing incident X-ray diffraction patterns revealed that the radiation tolerance of the Lu2-xCexTi2O7 decreases with increasing Ce-content. This correlation between radiation tolerance and Ce-content was interpreted in terms of the antisite defect formation energies of Lu2-xCexTi2O7 (x = 0, 0.5, 1) based on the density functional theory.

  20. Investigation of luminescence from LuAG: Mn4+ for physiological temperature sensing

    NASA Astrophysics Data System (ADS)

    Li, Fei; Cai, Jiajia; Chi, FengFeng; Chen, Yonghu; Duan, Changkui; Yin, Min

    2017-04-01

    Optical thermometry based on luminescent materials has garnered much attention due to its many advantages. But higher sensitivity is still expected in physiological temperature range which is of special significance in medicine and biology. For this purpose, quadrivalent manganese doped lutetium aluminum garnet, Lu3Al5O12: Mn4+, or simply LuAG: Mn4+, has been successfully synthesized by sol-gel method and its temperature dependent luminescence has been investigated in the present work. Compared to the common red emission phosphors Y3Al5O12: Mn4+ (YAG:Mn4+) with same structure, LuAG:Mn4+ has a stronger crystal field strength and a higher thermal-quenching activation energy (ΔE) of 5732 cm-1. Rapid thermal quenching of the Mn4+ luminescence occurred above room temperature around 90 °C for our LuAG:Mn4+ sample. Temperature dependent decay curves of Mn4+ emission from LuAG:Mn4+ revealed that an extraordinary high sensitivity can be achieved from luminescence lifetime measurements covering physiological temperature range with a sensitivity of 3.75% K-1 at 38 °C.

  1. Pressure induced phase transition and thermo-physical properties in LuX (X = N, P)

    NASA Astrophysics Data System (ADS)

    Sahoo, B. D.; Mukherjee, D.; Joshi, K. D.; Kaushik, T. C.; Gupta, Satish C.

    2016-04-01

    Detailed total energy calculations have been performed in lutetium pnictides (LuX, where X = N, P) to understand their high pressure structural stability. In LuN, the ambient rocksalt type structure (B1 phase) transforms to a tetragonal structure (B10 phase) at ˜240 GPa; whereas in LuP the orthorhombic structure (B33, space group Cmcm) emerges as a high pressure structure above 48 GPa. Both the transitions are found to be of first-order type with volume discontinuities of ˜6% and 8.2%, respectively. The high pressure phases B10 and B33 are found to be stable up to 400 GPa, respectively. Further, the structural stability predicted from static lattice calculations has been supported by lattice dynamical stability analysis. The present calculations rule out the B1 to B2 (CsCl type) structural phase transitions predicted to occur at 241 GPa in LuN and at 98 GPa in LuP by previous all-electron calculations (Gupta and Bhat 2013 J. Mol. Model 19 5343-54). The temperature dependence of several thermo-physical properties such as volume, bulk modulus, specific heat and thermal expansion coefficient of the rocksalt structure of these compounds calculated in the present study, using quasi-harmonic approximation, awaits confirmation by experimental studies.

  2. Spectral and structural features of Lu1 - x RE x BO3 compounds

    NASA Astrophysics Data System (ADS)

    Shmurak, S. Z.; Kedrov, V. V.; Kiselev, A. P.; Fursova, T. N.; Shmyt'ko, I. M.

    2015-08-01

    The luminescence spectra, luminescence excitation spectra, IR absorption spectra, and crystal structure of orthoborates Lu1 - x RE x BO3 ( RE = Eu, Gd, Tb, Y, Dy) have been investigated. It has been found that the solid solution consisting of a LuBO3 orthoborate, which has two stable structural modifications (calcite and vaterite), and an REBO3 orthoborate, which has one structural modification (vaterite), crystallizes only in the vaterite structure when the concentration of a rare-earth ion substituting for lutetium exceeds 15-20 at %. The investigation of the photoluminescence spectra has demonstrated that, for rare-earth ions Lu3+, Eu3+, Y3+, and Gd3+ in the vaterite modification of Lu1 - x RE x BO3 orthoborates, there are at least two positions that are not equivalent in the symmetry of the local environment. It has been established that the maximum intensity of the luminescence of the vaterite modification of Lu1 - x Tb x BO3 compounds synthesized at 970°C, which is observed at a terbium concentration of 15 at %, is several times higher than the maximum intensity of the luminescence of the calcite modification.

  3. A routine high-precision method for Lu-Hf isotope geochemistry and chronology

    USGS Publications Warehouse

    Patchett, P.J.; Tatsumoto, M.

    1981-01-01

    A method for chemical separation of Lu and Hf from rock, meteorite and mineral samples is described, together with a much improved mass spectrometric running technique for Hf. This allows (i) geo- and cosmochronology using the176Lu???176Hf+??- decay scheme, and (ii) geochemical studies of planetary processes in the earth and moon. Chemical yields for the three-stage ion-exchange column procedure average 90% for Hf. Chemical blanks are <0.2 ng for Lu and Hf. From 1 ??g of Hf, a total ion current of 0.5??10-11 Ampere can be maintained for 3-5 h, yielding 0.01-0.03% precision on the ratio176Hf/177Hf. Normalisation to179Hf/177Hf=0.7325 is used. Extensive results for the Johnson Matthey Hf standard JMC 475 are presented, and this sample is urged as an international mass spectrometric standard; suitable aliquots, prepared from a single batch of JMC 475, are available from Denver. Lu-Hf analyses of the standard rocks BCR-1 and JB-1 are given. The potential of the Lu-Hf method in isotope geochemistry is assessed. ?? 1980 Springer-Verlag.

  4. Production of 177Lu, a potential radionuclide for diagnostic and therapeutic applications

    NASA Astrophysics Data System (ADS)

    Khandaker, Mayeen Uddin; Haba, Hiromitsu; Kassim, Hasan Abu

    2015-04-01

    177gLu (T1/2=6.647d; Eβ-max=498.3 KeV, Iβ-total=100 % ; Eγ = 112.9498 keV, Iγ = 6.17%; Eγ = 208.3662 keV, I γ = 10.36%) is widely used in many clinical procedures due to its excellent decay characteristics. Production cross-sections of the natYb(d,x)177gLu reactions have been measured from a 24-MeV deuteron energy down to the threshold by using a stacked-foil activation technique combined with high resolution γ-ray spectrometry. An overall good agreement is found with some of the earlier measurements, whereas a partial agreement is obtained with the theoretical data extracted from the TENDL-2013 library. Physical thick target yield for the 177gLu radionuclide was deduced using the measured cross-sections. The deduced yield curves indicate that a low energy (<11 MeV) cyclotron and a highly enriched 176Yb target could be used to obtain 177gLu with negligible impurity from 177mLu.

  5. Surgery on varicose veins in the early Ottoman period performed by Serefeddin Sabuncuoğlu.

    PubMed

    Darçin, Osman Tansel; Andaç, Mehmet Halit

    2003-07-01

    Serefeddin Sabuncuoğlu, a pioneer of surgery, is known to be the author of first illustrated surgery textbook, Cerrahiyyetu'l Haniyye (Imperial Surgery), which was written in Turkish in 1465 AD at the age of 80 years. The purpose of this article is to describe his contributions to varicose vein surgery. In addition to vascular surgery, Serefeddin Sabuncuoğlu was interested in a wide range of surgical specialities including thoracic surgery, general surgery, pediatric surgery, ophthalmology, orthopedic surgery, urologic surgery, and obstetrics and gynecology. His book was the first illustrated textbook of surgery in the Turkish medical literature, containing color illustrations of surgical procedures, incisions, and instruments. The book has been known of for only the past 60 years. There are 137 different medical observations and recommendations in Cerrahiyyetu'l Haniyye, along with translated passages from the works of Ebu Kasim-ul Zahravi (Albucasis), Al-Tasrif (Textbook of Surgery), including Sabuncuoğlu's additional original contributions. In chapter 90 of the book, Sabuncuoğlu describes lower extremity varices and their surgical treatment and provides a few color illustrations. Although not recognized and rewarded in his time, Serefeddin Sabuncuoğlu was a great surgeon in Turkish-Islamic medical history. This review demonstrates that his textbook, Cerrahiyyetu'l Haniyye, was the first illustrated textbook including various surgical procedures, incisions, and instruments of varicose vein surgery.

  6. Raman and structural characterization of LuAlO{sub 3}

    SciTech Connect

    Casu, Alberto; Ricci, Pier Carlo

    2011-11-15

    The structural and vibrational properties of lutetium orthoaluminate perovskite (LuAlO{sub 3}) were investigated by means of Raman spectroscopy and EXAFS measurements. The analysis of Raman spectra taken in four different polarized configurations along the principal axes at 20 K and room temperature conditions permits to assign the principal vibrational modes in LuAP single crystals and to confirm the belonging to the D{sub 2h}{sup 16} space group. EXAFS measurements were performed at room temperature in order to obtain local structural informations on the first and next nearest neighbors around lutetium absorptions sites. Unit cell parameters and bond lengths were determined by the analysis of the EXAFS spectroscopy at the L{sub 3} absorption edge of lutetium. The informations thus gathered on this compound can offer a useful addition in the framework of a full structural characterization of LuAlO{sub 3}. - Graphical abstract: Raman active mode in LuAP crystal. Highlights: > Structural characterization of LuAlO{sub 3} is obtained by Raman and EXAFS spectroscopies. > Vibrational modes, temperature-dependent variations studied by Raman spectroscopy. > Cell parameters and local characterization obtained by EXAFS spectroscopy.

  7. Production of {sup 177}Lu, a potential radionuclide for diagnostic and therapeutic applications

    SciTech Connect

    Khandaker, Mayeen Uddin; Kassim, Hasan Abu; Haba, Hiromitsu

    2015-04-24

    {sup 177g}Lu (T{sub 1/2}=6.647d; E{sub β{sup −max}}=498.3KeV, I{sub β{sup −total}}=100%; E{sub γ} = 112.9498 keV, I{sub γ} = 6.17%; E{sub γ} = 208.3662 keV, I {sub γ} = 10.36%) is widely used in many clinical procedures due to its excellent decay characteristics. Production cross-sections of the {sup nat}Yb(d,x){sup 177g}Lu reactions have been measured from a 24-MeV deuteron energy down to the threshold by using a stacked-foil activation technique combined with high resolution γ-ray spectrometry. An overall good agreement is found with some of the earlier measurements, whereas a partial agreement is obtained with the theoretical data extracted from the TENDL-2013 library. Physical thick target yield for the {sup 177g}Lu radionuclide was deduced using the measured cross-sections. The deduced yield curves indicate that a low energy (<11 MeV) cyclotron and a highly enriched {sup 176}Yb target could be used to obtain {sup 177g}Lu with negligible impurity from {sup 177m}Lu.

  8. Synthesis of Er-doped Lu2O3 nanoparticles and transparent ceramics

    NASA Astrophysics Data System (ADS)

    Serivalsatit, K.; Wasanapiarnpong, T.; Kucera, C.; Ballato, J.

    2013-05-01

    Transparent rare earth-doped Lu2O3 ceramics have received much attention for use in solid-state scintillator and laser applications. The fabrication of these ceramics, however, requires ultrafine and uniform powders as precursors. Presented here is the synthesis of Er-doped Lu2O3 nanopowders by a solution precipitation method using Er-doped lutetium sulfate solution and hexamethylenetetramine as a precipitant and the fabrication of Er-doped Lu2O3 transparent ceramics from these nanopowders. The precipitated precursors were calcined at 1100 °C for 4 h in order to convert the precursors into Lu2O3 nanoparticles with an average particle size of 60 nm. Thermal decomposition and phase evolution of the precursors were studied by simultaneous thermal analysis (STA), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Er-doped Lu2O3 transparent ceramics were fabricated from these nanopowders using vacuum sintering followed by hot isostatic pressing at 1700 °C for 8 h. The transparent ceramics exhibit an optical transmittance of 78% at a wavelength of 1.55 μm.

  9. Evidence for inelastic neutron acceleration by the {sup 177}Lu isomer

    SciTech Connect

    Roig, O.; Belier, G.; Meot, V.; Daugas, J.-M.

    2006-11-15

    The neutron burnup cross section {sigma}{sub burnup}{sup m} on the long-lived metastable state of {sup 177}Lu has been measured from a specially designed isomeric target. The Maxwellian averaged cross section obtained for this reaction on {sup 177}Lu{sup m}(J{sup {pi}}=23/2{sup -}) is {sigma}{sub burnup}{sup m}=626{+-}45 b at the reactor temperature T=323 K. The difference between the burnup cross section and the previously measured capture cross section {sigma}{sub n,{gamma}} clearly shows a possible existence of {sup 177}Lu{sup m} deexcitation via (n,n{sup '}) inelastic neutron acceleration channels. The results are interpreted in terms of a statistical approach using parameters from a deformed optical potential calculation.

  10. Crystal growth and scintillation properties of Lu substituted CeBr3 single crystals

    NASA Astrophysics Data System (ADS)

    Ito, Tomoki; Yokota, Yuui; Kurosawa, Shunsuke; Král, Robert; Kamada, Kei; Pejchal, Jan; Ohashi, Yuji; Yoshikawa, Akira

    2016-10-01

    We grew Lu-substituted CeBr3 [(Ce1-xLux)Br3] crystals by a modified micro-pulling-down method to increase the effective atomic number and to investigate effects of the Lu substitution on the crystal growth, phase generation, chemical composition, and optical and scintillation properties. The (Ce1-xLux)Br3 crystals with x=0 and 0.01 had high transparency while the milky parts were generated in the crystals with x=0.05 and 0.20. By the analysis of chemical composition, the estimated Zeff increased to 47.9. On the other hand, the light yields were systematically decreased and decay times were increased with increasing Lu concentration.

  11. Composite phosphor films based on spherical Lu2O3:Eu3+ nanoparticles

    NASA Astrophysics Data System (ADS)

    Babaevskaya, N. V.; Kryzhanovskaya, A. S.; Matveevskaya, N. A.; Mateichenko, P. V.; Yavetskii, R. P.; Tolmachev, A. V.; Tret'yak, S. E.

    2011-02-01

    A nanopowder of Lu2O3:Eu3+ ( C Eu = 5 at.%) was obtained by coprecipitation with urea (NH2)2CO from aqueous solutions. Using this nanopowder, compact Lu2O3:Eu3+ films with thicknesses within 20-200 μm and a relative density up to 65% of the theoretical limit were deposited using the spin-coating and painting techniques. The films were characterized by scanning electron microscopy, X-ray diffraction, and X-ray luminescence (XRL) measurements. It is established that the XRL intensity depends on the phosphor/organic binder ratio and thickness of the film. The most intense XRL and most homogeneous structure are observed for 20-μm-thick Lu2O3:Eu3+ films.

  12. Thermal expansion, heat capacity and magnetostriction of RAl3 (R = Tm, Yb, Lu) single crystals

    SciTech Connect

    Bud'ko, S.; Frenerick, J.; Mun, E.; Canfield, P.; Schmiedeshoff, G.

    2007-12-13

    We present thermal expansion and longitudinal magnetostriction data for cubic RAl{sub 3} (R = Tm, Yb, Lu) single crystals. The thermal expansion coefficient for YbAl{sub 3} is consistent with an intermediate valence of the Yb ion, whereas the data for TmAl{sub 3} show crystal electric field contributions and have strong magnetic field dependences. de Haas-van Alphen like oscillations were observed in the magnetostriction data for YbAl{sub 3} and LuAl{sub 3}, several new extreme orbits were measured and their effective masses were estimated. Specific heat data taken at 0 and 140 kOe for both LuAl{sub 3} and TmAl{sub 3} for T {le} 200 K allow for the determination of a crystal electric field splitting scheme for TmAl{sub 3}.

  13. Theranostic Radiopharmaceuticals Based on Gold Nanoparticles Labeled with (177)Lu and Conjugated to Peptides.

    PubMed

    Ferro-Flores, Guillermina; Ocampo-García, Blanca E; Santos-Cuevas, Clara L; de María Ramírez, Flor; Azorín-Vega, Erika P; Meléndez-Alafort, Laura

    2015-01-01

    Gold nanoparticles (AuNPs) have been proposed for a variety of medical applications such as localized heat sources for cancer treatment and drug delivery systems. The conjugation of peptides to AuNPs produces stable multimeric systems with target-specific molecular recognition. Lutetium- 177 ((177)Lu) has been successfully used in peptide radionuclide therapy. Recently, (177)Lu-AuNPs conjugated to different peptides have been proposed as a new class of theranostic radiopharmaceuticals. These radioconjugates may function simultaneously as molecular imaging agents, radiotherapy systems and thermal-ablation systems. This article covers advancements in the design, synthesis, physicochemical characterization, molecular recognition assessment and preclinical therapeutic efficacy of gold nanoparticles radiolabeled with (177)Lu and conjugated to RGD (-Arg-Gly-Asp-), Lys(3)-Bombesin and Tat(49-57) peptides.

  14. Lu-Hf total-rock isochron for the eucrite meteorites

    NASA Technical Reports Server (NTRS)

    Patchett, P. J.; Tatsumoto, M.

    1980-01-01

    The isotope Lu-176 (2.6% of natural lutetium) decays by beta(-) to Hf-176, with a long half life. The first Lu-Hf isochron is presented. The eucrite meteorites, a suite of planetary igneous rocks of known age, 4,550 Myr, define a 10-point total-rock isochron with a slope of 0.0934 + or - 40, leading to a value of 3.53 + or - 0.14 x 10 to the 10th yr for the beta(-) decay half life of Lu-176. The isochron intercept of 0.27973 + or - 12 gives the initial Hf-176/Hf-177 for the inner solar system at the time of accretion.

  15. Transport properties of the topological semi-metal LuPtBi under pressure

    NASA Astrophysics Data System (ADS)

    Fallah Tafti, Fazel; Fujii, Takenori; Juneau-Fecteau, Alxandre; Rene de Cotret, Samuel; Doiron-Leyraud, Nicolas; Asamitsu, Atsushi; Taillefer, Louis; University of Sherbrooke Team; University of Tokyo Team

    2013-03-01

    We present high-pressure magneto-transport data on single crystals of LuPtBi, a member of the ternary half-Heusler family. Recent band structure calculations show that LuPtBi is a topological semi-metal at ambient pressure due to strong spin-orbit coupling. By decreasing the lattice parameter, equivalent to increasing pressure, the system should become a trivial insulator We have grown single crystals of LuPtBi and studied both the field dependence and the pressure dependence of their resistivity. The field dependence shows typical semi-metal behaviour, namely a weak temperature dependence and a large magneto-resistance. The pressure dependence shows a significant increase of resistivity and a decrease of magneto-resistance with increasing pressure. We compare our experimental results to the available theoretical work on the transport properties of topological semi-metals.

  16. Magnetic and magnetotransport properties of the orthorhombic perovskites (Lu,Ca)MnO3

    NASA Astrophysics Data System (ADS)

    Imamura, N.; Karppinen, M.; Motohashi, T.; Yamauchi, H.

    2008-01-01

    Here we extend the research of the (R,Ca)MnO3 perovskites to the smallest- R end member (Lu,Ca)MnO3 . Magnetic and magnetotransport properties of the (Lu1-xCax)MnO3 system are systematically investigated in regard to carrier doping. It is found that hole doping into the antiferromagnetic x=0.0 phase, LuMnO3 , causes a spin-glass-like magnetic competition in the wide doping range of 0.1≤x≤0.6 , whereas electron doping into the antiferromagnetic x=1.0 phase, CaMnO3 , induces a large magnetoresistance effect for 0.8≤x≤0.95 .

  17. Large magneto (thermo) dielectric effect in multiferroic orthorhombic LuMnO3

    NASA Astrophysics Data System (ADS)

    Wang, L. J.; Chai, Y. S.; Feng, S. M.; Zhu, J. L.; Manivannan, N.; Jin, C. Q.; Gong, Z. Z.; Wang, X. H.; Li, L. T.

    2012-06-01

    We have investigated the relation between ferroelectric and magnetic orders of orthorhombic (o-) LuMnO3 ceramics. The increase of dielectric constant ɛ exceeds 82% near incommensurate to commensurate E-type antiferromagnetic (AFM) spin ordering transition temperature TL, reflecting a large magneto (thermo) dielectric response. Meanwhile, distinct anomalies and thermal hysteresis behavior are observed near this temperature in both temperature dependence of ɛ and specific heat Cp, indicating a strong coupling between FE and magnetic orders in o-LuMnO3. Comparing to o-HoMnO3, TmMnO3, and YbMnO3 with similar E-type AFM ground state, o-LuMnO3 has the largest magneto (thermo) dielectric effect

  18. High speed corner and gap-seal computations using an LU-SGS scheme

    NASA Technical Reports Server (NTRS)

    Coirier, William J.

    1989-01-01

    The hybrid Lower-Upper Symmetric Gauss-Seidel (LU-SGS) algorithm was added to a widely used series of 2D/3D Euler/Navier-Stokes solvers and was demonstrated for a particular class of high-speed flows. A limited study was conducted to compare the hybrid LU-SGS for approximate Newton iteration and diagonalized Beam-Warming (DBW) schemes on a work and convergence history basis. The hybrid LU-SGS algorithm is more efficient and easier to implement than the DBW scheme originally present in the code for the cases considered. The code was validated for the hypersonic flow through two mutually perpendicular flat plates and then used to investigate the flow field in and around a simplified scramjet module gap seal configuration. Due to the similarities, the gap seal flow was compared to hypersonic corner flow at the same freestream conditions and Reynolds number.

  19. The optical properties of rare-earth multi-ferroelectric thin-film LuFeO3 and LuFe1-xMnxO3fabricated with Sol-gel method

    NASA Astrophysics Data System (ADS)

    Xu, Tingjing; Zhu, Lipin; Yang, Pingxiong; Chu, Junhao

    2009-08-01

    RMO3 (R=rare earth, M=Fe, Mn, Ni) is a kind of multi-ferroelectric material1 while Lu is a element which has been widely used in electroluminescence area. Material constituted with Fe and Lu is thought to have special properties on electromagnetic coupling due to the reactivity of Lu and the magnetism of Fe. For example, LuFe2O4 is a new type of electric ferroelectric material which has become more and more concerned after Ikeda reported it in the Nature magazine in 2005.2 We successfully fabricated another LuFeO3 thin film with sol-gel method on Si substrates with different constituents, and analyzed the structural, optical properties of the samples. We investigated the optical properties with UV-Vis, PL, etc. After Mn was doped, the properties were compared with the previous ones.

  20. Characterization of Pr:LuAG scintillating crystals for X-ray spectroscopy

    NASA Astrophysics Data System (ADS)

    Bertoni, R.; Bonesini, M.; Cervi, T.; Clemenza, M.; De Bari, A.; Falcone, A.; Mazza, R.; Menegolli, A.; Nastasi, M.; Rossella, M.

    2016-07-01

    The main features of the Pr doped Lu3Al5O12 (Pr:LuAG) scintillating crystals for X-ray spectroscopy applications have been studied using different radioactive sources and photo-detectors. Pr:LuAG is cheaper, compared to a Germanium detector, but with remarkable properties which make it useful for many applications, from fundamental physics measurements to the PET imaging for medical purposes: high density, elevate light yield, fast response, high energy resolution, no hygroscopicity. A sample of Pr:LuAG crystals with 14 mm×14 mm surface area and 13 mm thickness and a NaI crystal of the same surface and 26 mm thickness used as a reference have been characterized with several radioactive sources, emitting photons in the range 100-1000keV. Different light detectors were adopted for the Pr:LuAG studies, sensitive to its UV emission (peak at 310 nm): a 3 in. PMT (Hamamatsu R11065) and new arrays of Hamamatsu SiPM S13361, with siliconic resin as a window. Preliminary results are presented on the performance of the Pr:LuAG crystals, to be mounted in a 2 × 2 array to be tested in the 2015 run of the FAMU experiment at RIKEN-RAL muon facility. The goal is the detection of the X-rays (around 130 keV) emitted during the de-excitation processes of the muonic hydrogen after the excitation with an IR laser with wavelength set at the resonance of the hyperfine splitting, to measure the muonic atom proton radius with unprecedented precision.

  1. Magnetic and magnetoelastic phenomena in rare earth Dy/Lu superlattices and thin films

    SciTech Connect

    Beach, R.S.

    1993-01-01

    A new regime in the study of rare-earth magnetism began with the discovery that three dimensional long-range order can occur in epitaxial rare-earth/yttrium superlattice structures. In the Dy/Y system, helimagnetic order propagates along the c-axis growth direction through non-magnetic Y layers as thick as 100 [angstrom]. This phase persists even at 4.2 Kelvins, the lowest temperature measured, despite the fact that Dy is spontaneously ferromagnetic at T[sub c] = 85 K in bulk form. This thesis focuses on a new epitaxial system, dysprosium/lutetium, and demonstrates that, in this case, the ferromagnetic transition temperature of Dy is enhanced above the bulk value by nearly 100%. In addition, microscopic domains of magnetoelastic distortion appear at T[sub c], reducing the local symmetry of the structure from hexagonal to orthorhombic. Similar phenomena are found to occur in Lu/Dy/Lu trilayer films, which suggests that epitaxially induced stresses and strains are responsible for this novel effect. Further, the authors find in the Dy/Lu superlattices that the helical phase is coherent over regions encompassing several superlattice bilayers. The low temperature magnetic structures consist of either aligned or anti-aligned ferromagnetic Dy blocks. The anti-aligned phase, found in samples with Lu layers thicker than 22 [angstrom], Lu is more coherent than the helix. The aligned structure occurs only for samples with the thinnest Lu layers, and exhibits a shorter coherence length. The authors discuss the construction of the samples by molecular beam epitaxy, and the experimental methods by which their magnetic properties were determined. The authors address possible mechanisms underlying the observed physical phenomena, both the interlayer magnetic coupling and the enhancement of T[sub c].

  2. High precision Lu and Hf isotope analyses of both spiked and unspiked samples: A new approach

    NASA Astrophysics Data System (ADS)

    Lapen, Thomas J.; Mahlen, Nancy J.; Johnson, Clark M.; Beard, Brian L.

    2004-01-01

    The functional form of instrumentally produced mass fractionation associated with MC-ICP-MS analysis is not accurately known and therefore cannot be fully corrected by traditional approaches of internal normalization using power, linear, or exponential mass-bias laws. We present a method for robust correction of instrumentally produced mass-fractionation of both spiked and unspiked samples that can be applied to mass analysis of Hf as well as Nd, Sr, Os, etc. Correction of 176Hf/177Hf for unspiked samples follows a traditional approach of internal normalization using an exponential law, followed by normalization to a standard of known composition, such as JMC-475. For spiked samples, standards are used to characterize a linear instrumental mass-bias coefficient; the mass-bias coefficient is defined by the slope of a tie-line between measured and true values of a standard. This approximation results in identical precision and accuracy of measurements for spiked and unspiked samples (±0.005% 2σ, external reproducibility). The effects of the spike on the 176Hf/177Hf ratio and calculation of the molar spike-sample ratio is determined by a closed-form solution modified from the double-spike approach used for Fe isotope analysis by TIMS [Johnson and Beard, 1999]. The measured 176Lu/175Lu ratios are corrected by doping the sample with Er and using the 167Er/166Er ratio to externally normalize the 176Lu/175Lu ratio using an exponential law. Finally, spike-sample equilibration is confirmed for our sample dissolution protocol through analysis of varying physical mixtures of 1 Ga garnet and hornblende, where all the data lie on a mixing-line, within error, on a 176Lu/177Hf-176Hf/177Hf diagram. Precision of 176Lu/177Hf ratios is determined to be ±0.2% (2σ) for standards and for physical mixtures of garnet and hornblende.

  3. Evaluation of two intraoperative gamma detectors for assessment of (177)Lu activity concentration in vivo.

    PubMed

    Sandblom, Viktor; Ståhl, Ingun; Olofsson Bagge, Roger; Forssell-Aronsson, Eva

    2017-12-01

    Patients with somatostatin receptor-expressing neuroendocrine tumours can be treated with intravenously administered (177)Lu-octreotate. Few patients are cured with the present protocol due to the current dose limitation of normal organs at risk, such as the kidneys. By locally administering (177)Lu-octreotate to the liver for the purpose of treating liver metastases, a substantially reduced absorbed dose to organs at risk could be achieved. The development of such a technique requires the capability of measuring the (177)Lu activity concentration in tissues in vivo. The aim of this study was to evaluate different performance parameters of two commercially available intraoperative gamma detectors in order to investigate whether intraoperative gamma detector measurements could be used to determine (177)Lu activity concentration in vivo. Measurements were made using different sources containing (177)Lu. Response linearity, sensitivity, spatial resolution and its depth dependence, organ thickness dependence of the measured count rate and tumour detectability were assessed for two intraoperative gamma detectors. The two detectors (a scintillation and a semiconductor detector) showed differences in technical performance. For example, the sensitivity was higher for the scintillation detector, while the spatial resolution was better for the semiconductor detector. Regarding organ thickness dependence and tumour detectability, similar results were obtained for both detectors, and even relatively small simulated tumours of low tumour-to-background activity concentration ratios could be detected. Acceptable results were obtained for both detectors, although the semiconductor detector proved more advantageous for our purpose. The measurements demonstrated factors that must be corrected for, such as organ thickness or dead-time effects. Altogether, intraoperative gamma detector measurements could be used to determine (177)Lu activity concentration in vivo.

  4. [177Lu]Bz-DTPA-EGF: Preclinical characterization of a potential radionuclide targeting agent against glioma.

    PubMed

    Sundberg, Asa Liljegren; Gedda, Lars; Orlova, Anna; Bruskin, Alexander; Blomquist, Erik; Carlsson, Jörgen; Tolmachev, Vladimir

    2004-04-01

    Patients with glioblastoma multiforme have a poor prognosis due to recurrences originating from spread cells. The use of radionuclide targeting might increase the chance of inactivating single tumor cells with minimal damage to surrounding healthy tissue. As a target, overexpressed epidermal growth factor receptors (EGFR) may be used. A natural ligand to EGFR, the epidermal growth factor (EGF) is an attractive targeting agent due to its low molecular weight (6 kDa) and high affinity for EGFR. 177Lu (T(1/2) = 6.7 days) is a radionuclide well suited for treatment of small tumor cell clusters, since it emits relatively low-energy beta particles. The goal of this study was to prepare and preclinically evaluate both in vitro and in vivo the [177Lu]Bz-DTPA-EGF conjugate. The conjugate was characterized in vitro for its cell-binding properties, and in vivo for its pharmacokinetics and ability to target EGFR. [177Lu]Bz-DTPA-EGF bound to cultured U343 glioblastoma cells with an affinity of 1.9 nM. Interaction with EGFR led to rapid internalization, and more than 70% of the cell-associated radioactivity was internalized after 30 minutes of incubation. The retention of radioactivity was good, with more than 65% of the 177Lu still cell-associated after 2 days. Biodistribution studies of i.v. injected [177Lu]Bz-DTPA-EGF in NMRI mice demonstrated a rapid blood clearance. Most of the radioactivity was found in the liver and kidneys. The liver uptake was receptor-mediated, since it could be significantly reduced by preinjection of unlabeled EGF. In conclusion, [177Lu]Bz-DTPA-EGF seems to be a promising candidate for locoregional treatment of glioblastoma due to its high binding affinity, low molecular weight, and ability to target EGFR in vivo.

  5. Negative thermal expansion and anomalies of heat capacity of LuB50 at low temperatures

    SciTech Connect

    Novikov, V. V.; Zhemoedov, N. A.; Matovnikov, A. V.; Mitroshenkov, N. V.; Kuznetsov, S. V.; Bud'ko, S. L.

    2015-07-20

    Heat capacity and thermal expansion of LuB50 boride were experimentally studied in the 2–300 K temperature range. The data reveal an anomalous contribution to the heat capacity at low temperatures. The value of this contribution is proportional to the first degree of temperature. It was identified that this anomaly in heat capacity is caused by the effect of disorder in the LuB50 crystalline structure and it can be described in the soft atomic potential model (SAP). The parameters of the approximation were determined. The temperature dependence of LuB50 heat capacity in the whole temperature range was approximated by the sum of SAP contribution, Debye and two Einstein components. The parameters of SAP contribution for LuB50 were compared to the corresponding values for LuB66, which was studied earlier. Negative thermal expansion at low temperatures was experimentally observed for LuB50. The analysis of the experimental temperature dependence for the Gruneisen parameter of LuB50 suggested that the low-frequency oscillations, described in SAP mode, are responsible for the negative thermal expansion. As a result, the glasslike character of the behavior of LuB50 thermal characteristics at low temperatures was confirmed.

  6. Disorder-Sensitive Superconductivity and Bonding Network in the Iron-Silicide Superconductor Lu2Fe3Si5

    NASA Astrophysics Data System (ADS)

    Watanabe, Tadataka; Okuyama, Hiroaki; Takase, Kouichi; Takano, Yoshiki; Yoshida, Fumiko; Moriyoshi, Chikako; Kuroiwa, Yoshihiro

    2010-03-01

    Iron silicide superconductor Lu2Fe3Si5 exhibits relatively high Tc = 6.0 K among Fe-based substances. Recent specific heat, penetration depth, and thermal conductivity measurements have provided evidences for the multigap superconductivity. We have studied non-magnetic and magnetic impurity effects on superconductivity in Lu2Fe3Si5 by investigating Tc variations in non-magnetic (Lu1-xScx)2Fe3Si5, (Lu1-xYx)2Fe3Si5 and magnetic (Lu1-xDyx)2Fe3Si5. Small amount of non-magnetic impurities (Sc and Y) on the Lu-site rapidly depresses Tc in accordance with the increase in the residual resistivity. Such a disorder-sensitive superconductivity strongly suggests the sign reversal of the superconducting order parameter. Lu2Fe3Si5 has a complicated crystal structure compared to other multigap superconductors such as MgB2 and iron pnictides. Thus it is important to map out the accurate bonding network in the crystal structure for the better understanding of the electronic structure. We have observed the charge density distribution of Lu2Fe3Si5 by analyzing the synchrotron radiation powder diffraction data using the maximum entropy method/Rietveld method.

  7. A randomized clinical study of Lu AA21004 in the prevention of relapse in patients with major depressive disorder.

    PubMed

    Boulenger, Jean-Philippe; Loft, Henrik; Florea, Ioana

    2012-11-01

    The efficacy and tolerability of Lu AA21004 in the prevention of relapse of major depressive disorder (MDD) in patients in remission after acute treatment was evaluated. Patients (n=639) aged 18-75 years with a primary diagnosis of MDD with a current major depressive episode (MDE) ≥4 weeks' duration, at least one prior MDE and a MADRS total score ≥26 received 12-week, open-label Lu AA21004 at 5 or 10mg/day. Patients in remission (MADRS ≤10) at both weeks 10 and 12 were assigned to double-blind treatment with either placebo or Lu AA21004 (fixed dose from Week 8).Patients (n=396) were treated, after random assignment to placebo (n=192) or Lu AA21004 (n=204). The primary analysis of time to relapse (full-analysis set, Cox proportional hazard model) showed a statistically significant difference in favour of Lu AA21004 versus placebo with a hazard ratio of 2.01 (95% confidence interval: 1.26-3.21; p=0.0035). The proportion of patients who relapsed was 13% in the Lu AA21004 group (n=27) and 26% in the placebo group (n=50). The withdrawal rates due to adverse events were 8% (open-label), and 3% (placebo) and 8% (Lu AA21004) (double-blind). Thus, Lu AA21004 was effective in preventing relapse of MDD and was well tolerated as maintenance treatment.

  8. Luminescent and scintillation properties of Lu3Al5O12:Sc single crystal and single crystalline films

    NASA Astrophysics Data System (ADS)

    Zorenko, Y.; Gorbenko, V.; Voznyak, T.; Savchyn, V.; Nizhankovskiy, S.; Dan'ko, A.; Puzikov, V.; Laguta, V.; Mares, J. A.; Nikl, M.; Nejezchleb, K.; Batentschuk, M.; Winnacker, A.

    2012-10-01

    The work is dedicated to growth by the liquid phase epitaxy method and study of the luminescence and scintillation properties of Sc3+ doped single crystalline films (SCF) of Lu3Al5O12 (LuAG) garnet. The scintillation properties of SCF are compared with single crystal (SC) analogues grown by the Horizontal Direct Crystallization and Czochralski methods. We consider the dependence of intensity of the Sc3+ emission in LuAG host on the activator concentration and influence of flux contamination on the light yield (LY) of the Sc3+ luminescence in LuAG:Sc SCF with respect to their SC counterparts and the reference YAP:Ce scintillator. From the NMR investigations of LuAG:Sc SCF we confirm the substitution by Sc3+ ions both the octahedral and dodecahedral positions of LuAG host and formation of the ScAl and ScLu related emission centers, respectively. We also show that the luminescence spectrum in the UV range and decay kinetics of LuAG:Sc SCF can be effectively tuned by changing the scandium content.

  9. Screening anaphylactic components of MaiLuoNing injection by using rat basophilic leukemia-2H3 cell membrane chromatography coupled with HPLC-ESI-TOF-MS.

    PubMed

    Han, Shengli; Lv, Yanni; Xue, Wenjing; Cao, Jiao; Cui, Ronghua; Zhang, Tao

    2016-02-01

    MaiLuoNing injection is a traditional Chinese medicine that used clinically since the 1950s in China. However, anaphylactic reactions, through the potentiation of mast cell degranulation, have been reported. In the present study, a rat basophilic leukemia-2H3 cell membrane chromatography coupled with high-performance liquid chromatography and electrospray ionization-ion trap-time of flight-mass spectrometry method was established for screening, analyzing, and identifying the potential anaphylactic components of MaiLuoNing injection. Harpagoside, a potential degranulator of rat basophilic leukemia-2H3 cells, was retained in rat basophilic leukemia-2H3 cell membrane chromatography. We aimed to evaluate the retained components to determine which of those were capable of inducing degranulation of basophilic leukemia cells. A β-hexosaminidase assay revealed that harpagoside can induce rat basophilic leukemia-2H3 cell degranulation in a dose-dependent manner. BLBA/c mice also exhibit passive cutaneous anaphylaxis in response to harpagoside. These results indicate that rat basophilic leukemia-2H3 cell membrane chromatography coupled with high-performance liquid chromatography and electrospray ionization ion trap time-of-flight mass spectrometry is effective in screening for the anaphylactic components of MaiLuoNing injection.

  10. The regulation of prostitution in Beyoğlu (1875-1915).

    PubMed

    özbek, Müge

    2010-01-01

    This study examines the development and nature of the regulation of prostitution in Beyoğlu during the late Ottoman Empire with special emphasis on the way the regulationist regime reinforced existing patterns of class and gender domination. The regulation of prostitution became a matter of urgency in the last decades of the nineteenth century in Istanbul, particularly in Beyoğlu, the cosmopolitan centre of the city. Through this process, the protests of the local residents of the area objecting to the proliferation of prostitution in their neighbourhoods played a crucial role in prompting the governmental authorities to tighten the regulations.

  11. Three-dimensional magnetic correlations in multiferroic LuFe2O4

    SciTech Connect

    Christianson, Andrew D; Lumsden, Mark D; Angst, Manuel; Yamani, Z.; Tian, Wei; Jin, Rongying; Payzant, E Andrew; Nagler, Stephen E; Sales, Brian C; Mandrus, David

    2008-01-01

    We present single crystal neutron diffraction measurements on multiferroic LuFe{sub 2}O{sub 4}. Magnetic reflections are observed below transitions at 240 and 175 K indicating that the magnetic interactions in LuFe{sub 2}O{sub 4} are three-dimensional in character. The magnetic structure is refined as a ferrimagnetic spin configuration below the 240 K transition. Below 175 K a significant broadening of the magnetic peaks is observed along with the buildup of a diffuse component to the magnetic scattering.

  12. Optimization of LSO/LuYAP phoswich detector for small animal PET

    NASA Astrophysics Data System (ADS)

    Jung, Jin Ho; Choi, Yong; Chung, Yong Hyun; Devroede, Olivier; Krieguer, Magalie; Bruyndonckx, Peter; Tavernier, Stefaan

    2007-02-01

    LSO/LuYAP phoswich detectors for small animal PET were developed to measure the depth of interaction (DOI), and to improve the spatial resolution at the edge of the field of view (FOV). The aim of this study was to optimize the optical coupling conditions between the crystal and photomultiplier tube (PMT) to maximize the light-collection efficiency, and to develop a method for rejecting scatter events by applying an equal energy window in each crystal layer. The light yields of the phoswich detector were estimated by changing the refractive index of the optical coupling material using a DETECT simulation. The accuracy of the DOI measurement on the phoswich detector, using an optical coupling material with the optimal light yield, were evaluated experimentally and compared with the air condition. The energy window for the photopeak events cannot be applied properly because the light outputs of LSO and LuYAP are different. The LSO/LuYAP photopeaks need to be superposed in order to effectively discriminate the scattered events by applying an equal energy window. The photopeaks of the LSO and LuYAP can be superposed by inserting a reflecting material between the crystals. The optimal coverage ratio of the inserting material was derived from a DETECT simulation, and its performance was investigated. In the simulation result, optimal refractive index of the optical coupling material was 1.7. The average DOI measurement errors of the LSO/LuYAP were 0.6%/3.4% and 4.9%/41.4% in the phoswich detector with and without an optical coupling material, respectively. The photopeaks of the LSO and LuYAP were superposed by covering 75% of the contact surface between the crystals with white Teflon. The DOI measurement errors of the LSO/LuYAP were 0.2%/2.4%. In this study, the optimal condition of the optical coupling material inserted between the crystal and PMT was derived to improve the accuracy of DOI measurement, and a photopeak superposition method of the LSO and LuYAP was

  13. A new scheduling algorithm for parallel sparse LU factorization with static pivoting

    SciTech Connect

    Grigori, Laura; Li, Xiaoye S.

    2002-08-20

    In this paper we present a static scheduling algorithm for parallel sparse LU factorization with static pivoting. The algorithm is divided into mapping and scheduling phases, using the symmetric pruned graphs of L' and U to represent dependencies. The scheduling algorithm is designed for driving the parallel execution of the factorization on a distributed-memory architecture. Experimental results and comparisons with SuperLU{_}DIST are reported after applying this algorithm on real world application matrices on an IBM SP RS/6000 distributed memory machine.

  14. MS Malenchenko and MS Lu conduct electrical work in Zvezda during STS-106

    NASA Image and Video Library

    2000-09-13

    S106-E-5202 (13 September 2000) --- Cosmonaut Yuri I. Malenchenko, mission specialist representing the Russian Aviation and Space Agency, teams up with astronaut Edward T. Lu for some electrical work aboard the Zvezda service module on the International Space Station (ISS). Electrical work was the hallmark of the day as four of the mission specialists aboard ISS (temporarily docked with the Space Shuttle Atlantis) replaced batteries inside the Zarya and Zvezda modules while supply transfer continued around them. Astronaut Edward T. Lu, is out of frame at right.

  15. Communication Improvement for the LU NAS Parallel Benchmark: A Model for Efficient Parallel Relaxation Schemes

    NASA Technical Reports Server (NTRS)

    Yarrow, Maurice; VanderWijngaart, Rob; Kutler, Paul (Technical Monitor)

    1997-01-01

    The first release of the MPI version of the LU NAS Parallel Benchmark (NPB2.0) performed poorly compared to its companion NPB2.0 codes. The later LU release (NPB2.1 & 2.2) runs up to two and a half times faster, thanks to a revised point access scheme and related communications scheme. The new scheme sends substantially fewer messages. is cache "friendly", and has a better load balance. We detail the, observations and modifications that resulted in this efficiency improvement, and show that the poor behavior of the original code resulted from deriving a message passing scheme from an algorithm originally devised for a vector architecture.

  16. High efficient actively Q-switched Ho:LuAG laser.

    PubMed

    Duan, Xiaoming; Yao, Baoquan; Li, Gang; Ju, Youlun; Wang, Yuezhu; Zhao, Guangjun

    2009-11-23

    We present the room temperature Q-switched performances of a Ho:LuAG laser operated at 2.1 microm. At the repetition rate of 10 kHz, the maximum average output power of 9.9 W with a slope efficiency of 69.9% relative to absorbed pump power was obtained in Ho:LuAG laser. Also, the minimum pulse width of 33.0 ns was obtained, corresponding to the peak power was 30.0 kW.

  17. Scintillation properties of Pr-activated LuAlO 3

    NASA Astrophysics Data System (ADS)

    Drozdowski, Winicjusz; Wojtowicz, Andrzej J.; Wiśniewski, Dariusz; Łukasiewicz, Tadeusz; Kisielewski, Jarosław

    2006-01-01

    Praseodymium activated LuAlO 3 (LuAP) crystals have been grown using the Czochralski method at ITME, Warsaw. In this communication the measurements of radioluminescence (RL), low temperature thermoluminescence (TL), room temperature afterglow (AG), scintillation light yields (LY), and scintillation time profiles (STP), performed on polished 2 × 2 × 10 mm pixels with three Pr concentrations (0.003, 0.04, and 0.08 at.%), are reported. Two sets of samples are compared: (i) "as grown", and (ii) annealed in H 2 atmosphere.

  18. Esthesioneuroblastoma (olfactory neuroblastoma) treated with 111In-octreotide and 177Lu-DOTATATE PRRT.

    PubMed

    Makis, William; McCann, Karey; McEwan, Alexander J B

    2015-04-01

    A 51-year-old man with a recurrent metastatic esthesioneuroblastoma (olfactory neuroblastoma) was referred for peptide receptor radionuclide therapy (PRRT). He received 4 treatments of 111In-octreotide over 8 months and 3 treatments of 177Lu-DOTATATE over 4 months, which helped alleviate his symptoms and improved his quality of life; however, the tumor ultimately progressed and he passed away shortly thereafter. PRRT with 111In-octreotide or 177Lu-DOTATATE could play a role in the management of esthesioneuroblastoma.

  19. Passively mode-locked Nd:LuVO(4) laser with a GaAs wafer.

    PubMed

    Yu, Haohai; Zhang, Huaijin; Wang, Zhengping; Wang, Jiyang; Yu, Yonggui; Jiang, Minhua; Tang, Dingyuan; Xie, Guoqiang; Luo, Hang

    2008-02-01

    We report on the passive mode locking of a diode-pumped Nd:LuVO(4) laser with a GaAs wafer as output coupler. Using the interference modulation effect of the GaAs wafer, high-power continuous-wave mode locking with a pulse width of about 7.1 ps and an average output power of 3.11 W was achieved. Our result shows that Nd:LuVO(4) could be an excellent gain medium for diode-pumped high-power mode-locked lasers.

  20. Flux growth of MBO3 (M=Fe, Ga, In, Sc, Lu) single crystals

    NASA Astrophysics Data System (ADS)

    Ovchinnikov, S. G.; Rudenko, V. V.

    2016-12-01

    The temperatures for saturation of the MBO3 (M=Fe, Ga, In, Sc, Lu) compounds in the M2O3-B2O3- (70 PbO-30 PbF2, wt%) solvents are determined. The growth rates of FeBO3 and GaBO3 crystal faces as functions of the flux supercooling are obtained. It is demonstrated that the bulk FeBO3 and GaBO3 crystals can be grown in a narrow flux supercooling range using a controlled seeding technique. The MBO3 (M=In, Sc, Lu) crystals in the form of (111) plates are synthesized by spontaneous crystallization.

  1. Proton decay studies of the light Lu, Tm and Ho isotopes

    SciTech Connect

    Batchelder, J. C.; Bingham, C. R.; Gross, C. J.; Grzywacz, R.; Rykaczewski, K.; Toth, K. S.; Zganjar, E. F.; Akovali, Y.; Davinson, T.; Ginter, T. N.

    1999-09-02

    A double-sided Si-strip detector system has been installed and commissioned at the focal plane of the Recoil Mass Spectrometer at the Holifield Radioactive Ion Beam Facility. The system can be used for heavy charged particle emission studies with half-lives as low as a few {mu}sec. In this paper we present identification and study of the decay properties of the five new proton emitters: {sup 140}Ho, {sup 141m}Ho, {sup 145}Tm, {sup 150m}Lu and {sup 151m}Lu. (c) 1999 American Institute of Physics.

  2. Isomeric ratio measurements for the radiative neutron capture 176Lu(n,γ) at DANCE

    NASA Astrophysics Data System (ADS)

    Denis-Petit, D.; Roig, O.; Méot, V.; Morillon, B.; Romain, P.; Jandel, M.; Kawano, T.; Vieira, D. J.; Bond, E. M.; Bredeweg, T. A.; Couture, A. J.; Haight, R. C.; Keksis, A. L.; Rundberg, R. S.; Ullmann, J. L.

    2017-09-01

    The isomeric ratios for the neutron capture reaction 176Lu(n,γ) to the Jπ = 5/2-, 761.7 keV, T1/2 = 32.8 ns and the Jπ = 15/2+, 1356.9 keV, T1/2 = 11.1 ns levels of 177Lu, have been measured for the first time with the Detector for Advanced Neutron Capture Experiments (DANCE) at the Los Alamos National Laboratory. These measured isomeric ratios are compared with TALYS calculations.

  3. Structural and dielectric properties of the lutetium (Lu) and yttrium (Y) doped nickel ferrite

    SciTech Connect

    Ugendar, Kodam Markandeyulu, G.

    2014-04-24

    The structural and dielectric characteristics of NiFe{sub 1.925}R{sub 0.075}O{sub 4} (R=Lu,Y) were investigated. The material crystallize in the cubic inverse spinel phase with a very small amount of RFeO{sub 3} (R=Lu,Y) as the additional phase. Frequency variation of the dielectric constant shows the dispersion that can be modeled with a modified Debye's function, which considers the possibility of more than one ion, contributing to the relaxation. Impedance spectroscopic analysis indicates the different relaxation mechanisms, bulk grain and grain-boundary contributions to the electrical conductivity and capacitance of these materials.

  4. Surface and electronic structure of epitaxial PtLuSb (001) thin films

    SciTech Connect

    Patel, Sahil J.; Kawasaki, Jason K.; Logan, John; Schultz, Brian D.; Adell, J.; Thiagarajan, B.; Mikkelsen, A.; Palmstrøm, Chris J.

    2014-05-19

    The surface and electronic structure of single crystal thin films of PtLuSb (001) grown by molecular beam epitaxy were studied. Scanning tunneling spectroscopy (STS), photoemission spectroscopy, and temperature dependent Hall measurements of PtLuSb thin films are consistent with a zero-gap semiconductor or semi-metal. STS and photoemission measurements show a decrease in density of states approaching the Fermi level for both valence and conduction bands as well as a slight shift of the Fermi level position into the valence band. Temperature dependent Hall measurements also corroborate the Fermi level position by measurement of p-type carriers.

  5. Magnetic excitations in multiferroic LuMnO3 studied by inelastic neutron scattering

    NASA Astrophysics Data System (ADS)

    Lewtas, H. J.; Boothroyd, A. T.; Rotter, M.; Prabhakaran, D.; Müller, H.; Le, M. D.; Roessli, B.; Gavilano, J.; Bourges, P.

    2010-11-01

    We present data on the magnetic and magnetoelastic coupling in the hexagonal multiferroic manganite LuMnO3 from inelastic neutron scattering, magnetization, and thermal-expansion measurements. We measured the magnon dispersion along the main symmetry directions and used this data to determine the principal exchange parameters from a spin-wave model. An analysis of the magnetic anisotropy in terms of the crystal field acting on the Mn is presented. We compare the results for LuMnO3 with data on other hexagonal RMnO3 compounds.

  6. A Randomized Phase 2 Trial of 177Lu Radiolabeled Anti-PSMA Biochemically Monoclonal Antibody J591 in Patients with High-Risk Castrate, Biochemically Relapsed Prostate Cancer

    DTIC Science & Technology

    2010-09-01

    hypothesis is that the addition of 177Lu- J591 to ketoconazole will improve time to radiographically apparent metastases in men with biochemically...endpoint will be to compare the percentage of men with metastases at 18 months receiving ketoconazole plus 177Lu-J591 vs ketoconazole plus trace...phase II trial of 177lu radiolabeled monoclonal antibody J591 (177Lu-J591) and ketoconazole in patients (pts) with high-risk castrate biochemically

  7. Comparison of the luminescent properties of LuAG:Pr nanopowders, crystals and films using synchrotron radiation

    NASA Astrophysics Data System (ADS)

    Gorbenko, V.; Zych, E.; Voznyak, T.; Nizankovskiy, S.; Zorenko, T.; Zorenko, Yu.

    2017-04-01

    Comparison of the luminescent properties of nanopowder, single crystal and single crystalline film of Pr3+ doped Pr-doped Lu3Al5O12 garnet (LuAG:Pr) prepared by the different technological methods is performed in this work using the time-resolved emission spectroscopy under excitation by synchrotron radiation with an energy of 3.7-25 eV at 300 K and 10 K. The notable differences in the properties of the Pr3+ luminescence are observed in LuAG:Pr crystals and films caused by involving the LuAl antisite defects and oxygen vacancies in crystals and Pb2+ flux related dopant in films in the excitation processes of the Pr3+ luminescence. At the same time, we have also found that the influence of host defects on the Pr3+ luminescence is significantly smaller in the LuAG:Pr nanopowders.

  8. Half-life measurement of the medical radioisotope 177Lu produced from the 176Yb(n,γ) reaction

    NASA Astrophysics Data System (ADS)

    Ferreira, K. M.; Collins, S. M.; Fenwick, A. J.

    2017-09-01

    177Lu is a medium energy beta-emitter commonly used in Nuclear Medicine for radiotherapeutic applications. In this work, the half-life of 177Lu has been measured using a re-entrant ionisation chamber over a period of 82 days (approximately 12 half-lives). Unlike the majority of previous studies, the material used in this work was produced via the 176Yb(n,γ)177Yb reaction followed by the β-decay to 177Lu, producing insignificant quantities of 177mLu. This has resulted in the most precise half-life measurement of 177Lu to date. A half-life of 6.6430 (11) days has been determined. This value is in statistical agreement with the currently recommended half-life of 6.6463 (15) days (z-score = 1.8).

  9. ¹⁷⁷Lu-Labeled Agents for Neuroendocrine Tumor Therapy and Bone Pain Palliation in Uruguay.

    PubMed

    Balter, Henia; Victoria, Trindade; Mariella, Terán; Javier, Gaudiano; Rodolfo, Ferrando; Andrea, Paolino; Graciela, Rodriguez; Juan, Hermida; Eugenia, De Marco; Patricia, Oliver

    2016-01-01

    Lutetium-177 is an emerging radionuclide due its convenient chemical and nuclear properties. In this paper we describe the development and evaluation in Uruguay of the targeted 177Lu labelled radiopharmaceuticals EDTMP (for bone pain palliation) and DOTA-TATE (neuroendocrine tumors). We optimized the preparation of these 177Lu radiopharmaceuticals including radiolabelling, quality control methods, in vitro and in vivo stability and their therapeutic application in patients. Radiation dosimetry aspects of 177Lu are also included. Nine male patients with prostate cancer and four female patients with breast carcinoma with multiple bone metastatic lesions were treated with 177Lu-EDTMP. Four patients with gastroentheropancreatic neuroendocrine tumors (GEP-NET) and one patient with bronchial NET were treated with 1- 3 cycles with a cumulative dose of 4.44-22.2 GBq of 177Lu-DOTA-TATE. Scintigraphic images of the patients treated with 177Lu-EDTMP evidenced high and rapid uptake in bone metastasis, remaining after 7 days post administration. Images allow skeletal visualization with high definition and demonstrate increased uptake in bone metastases. For 177Lu-DOTA-TATE, partial remissions were obtained in 4 patients and the remaining patient did not show significant progression 3 months after the second cycle. No serious adverse effects were registered, even in two patients with confirmed renal disease and high risk for renal disease Dosimetry assessments confirm the predictive value of the personalized therapy with radiolabelled peptides. We found it is possible to accumulate high therapeutic doses in tumours in sequential administrations of 177Lu-DOTA-TATE, increasing the probability of biological response without significant impairment of the renal function in patients with risk factors. These results demonstrate the attractive therapeutic properties of these two 177Lu labelled agents and the feasibility of this metabolic therapy in regions far away from 177Lu producing

  10. Meteorite zircon constraints on the bulk Lu-Hf isotope composition and early differentiation of the Earth.

    PubMed

    Iizuka, Tsuyoshi; Yamaguchi, Takao; Hibiya, Yuki; Amelin, Yuri

    2015-04-28

    Knowledge of planetary differentiation is crucial for understanding the chemical and thermal evolution of terrestrial planets. The (176)Lu-(176)Hf radioactive decay system has been widely used to constrain the timescales and mechanisms of silicate differentiation on Earth, but the data interpretation requires accurate estimation of Hf isotope evolution of the bulk Earth. Because both Lu and Hf are refractory lithophile elements, the isotope evolution can be potentially extrapolated from the present-day (176)Hf/(177)Hf and (176)Lu/(177)Hf in undifferentiated chondrite meteorites. However, these ratios in chondrites are highly variable due to the metamorphic redistribution of Lu and Hf, making it difficult to ascertain the correct reference values for the bulk Earth. In addition, it has been proposed that chondrites contain excess (176)Hf due to the accelerated decay of (176)Lu resulting from photoexcitation to a short-lived isomer. If so, the paradigm of a chondritic Earth would be invalid for the Lu-Hf system. Herein we report the first, to our knowledge, high-precision Lu-Hf isotope analysis of meteorite crystalline zircon, a mineral that is resistant to metamorphism and has low Lu/Hf. We use the meteorite zircon data to define the Solar System initial (176)Hf/(177)Hf (0.279781 ± 0.000018) and further to identify pristine chondrites that contain no excess (176)Hf and accurately represent the Lu-Hf system of the bulk Earth ((176)Hf/(177)Hf = 0.282793 ± 0.000011; (176)Lu/(177)Hf = 0.0338 ± 0.0001). Our results provide firm evidence that the most primitive Hf in terrestrial zircon reflects the development of a chemically enriched silicate reservoir on Earth as far back as 4.5 billion years ago.

  11. Lu-Hf isotope systematics of fossil biogenic apatite and their effects on geochronology

    NASA Astrophysics Data System (ADS)

    Herwartz, Daniel; Münker, Carsten; Tütken, Thomas; Hoffmann, J. Elis; Wittke, Andreas; Barbier, Bruno

    2013-01-01

    Reliable methods for direct dating of biogenic apatite from pre-Pleistocene fossils are currently not available, and recent attempts using the Lu-Hf decay system yielded highly inaccurate ages for both bones and teeth. The geological processes accounting for this poor accuracy of Lu-Hf chronometry are not yet understood. Here we explore Lu-Hf systematics in fossil bones and teeth in detail, by applying five different sample digestion techniques that are tested on bones and composites of bone and sediment. Our current dataset implies that dissolution methods only slightly affect the resulting Lu-Hf ages, while clear differences between the individual digestion techniques became apparent for element concentrations. By analysing the insoluble leftovers from incomplete sample dissolution, four main reservoirs of Hf in fossil bones were identified: (1) a radiogenic end-member associated with apatite; (2) an unradiogenic end-member represented by the authigenic minerals or the embedding sediment; (3) a highly unradiogenic end-member that can be attributed to detrital zircon; and (4) a moderately soluble phase (probably a Zr(Hf)-phosphate) that yielded very low Lu/Hf but a highly radiogenic Hf isotope composition at the same time. This Zr(Hf)-phase must have been precipitated within the fossil bone sample at a late stage of burial history, thereby incorporating radiogenic 176Hf released from apatite surfaces over geological timescales. A second focus of our study is the effect of different sediment matrices and of crystal size on the preservation of pristine Lu-Hf isotope compositions in bioapatite. Because near-depositional Lu-Hf ages of phosphate fossils have previously been reported for the London Clay (England) and a calcareous marl from Tendaguru (Tanzania), we herein investigate specimens fossilised in carbonate matrices (calcareous marl from Oker, Germany; carbonate concretions from the Santana Formation, Brazil; carbonate from the Eifel, Germany) and argillaceous

  12. Weak Antilocalization Effect and Noncentrosymmetric Superconductivity in a Topologically Nontrivial Semimetal LuPdBi

    PubMed Central

    Xu, Guizhou; Wang, Wenhong; Zhang, Xiaoming; Du, Yin; Liu, Enke; Wang, Shouguo; Wu, Guangheng; Liu, Zhongyuan; Zhang, Xi Xiang

    2014-01-01

    A large number of half-Heusler compounds have been recently proposed as three-dimensional (3D) topological insulators (TIs) with tunable physical properties. However, no transport measurements associated with the topological surface states have been observed in these half-Heusler candidates due to the dominating contribution from bulk electrical conductance. Here we show that, by reducing the mobility of bulk carriers, a two-dimensional (2D) weak antilocalization (WAL) effect, one of the hallmarks of topological surface states, was experimentally revealed from the tilted magnetic field dependence of magnetoconductance in a topologically nontrivial semimetal LuPdBi. Besides the observation of a 2D WAL effect, a superconducting transition was revealed at Tc ~ 1.7 K in the same bulk LuPdBi. Quantitative analysis within the framework of a generalized BCS theory leads to the conclusion that the noncentrosymmetric superconductivity of LuPdBi is fully gapped with a possibly unconventional pairing character. The co-existence of superconductivity and the transport signature of topological surface states in the same bulk alloy suggests that LuPdBi represents a very promising candidate as a topological superconductor. PMID:25043549

  13. Weak antilocalization effect and noncentrosymmetric superconductivity in a topologically nontrivial semimetal LuPdBi.

    PubMed

    Xu, Guizhou; Wang, Wenhong; Zhang, Xiaoming; Du, Yin; Liu, Enke; Wang, Shouguo; Wu, Guangheng; Liu, Zhongyuan; Zhang, Xi Xiang

    2014-07-21

    A large number of half-Heusler compounds have been recently proposed as three-dimensional (3D) topological insulators (TIs) with tunable physical properties. However, no transport measurements associated with the topological surface states have been observed in these half-Heusler candidates due to the dominating contribution from bulk electrical conductance. Here we show that, by reducing the mobility of bulk carriers, a two-dimensional (2D) weak antilocalization (WAL) effect, one of the hallmarks of topological surface states, was experimentally revealed from the tilted magnetic field dependence of magnetoconductance in a topologically nontrivial semimetal LuPdBi. Besides the observation of a 2D WAL effect, a superconducting transition was revealed at Tc ~ 1.7 K in the same bulk LuPdBi. Quantitative analysis within the framework of a generalized BCS theory leads to the conclusion that the noncentrosymmetric superconductivity of LuPdBi is fully gapped with a possibly unconventional pairing character. The co-existence of superconductivity and the transport signature of topological surface states in the same bulk alloy suggests that LuPdBi represents a very promising candidate as a topological superconductor.

  14. A new photocatalyst of LuFeO3 for the dye degradation

    NASA Astrophysics Data System (ADS)

    Zhou, M.; Yang, H.; Xian, T.; Zhang, C. R.

    2015-08-01

    A polyacrylamide gel route was introduced to synthesize LuFeO3 particles, where the effects of calcination temperature, calcination time and chelating agent on the products were investigated. By varying the experimental conditions, several LuFeO3 samples with sphere-, ellipsoid- and worm-like morphologies and average particle sizes of 200-270 nm were prepared. The photocatalytic activity of LuFeO3 samples was evaluated by degrading rhodamine B (RhB) under simulated-sunlight irradiation, revealing that they exhibit a pronounced photocatalytic activity. The effects of p-benzoquinone (BQ), ethanol and oxalic acid (OA) on the photocatalytic efficiency were investigated. It is observed that BQ has almost no effect on the photocatalytic degradation of RhB, ethanol exhibits a substantial suppression of RhB degradation, while OA significantly enhances the photocatalytic efficiency. Hydroxyl (•OH) radicals were examined by fluorimetry using terephthalic acid as a probe molecule, and are found to be produced over the simulated-sunlight irradiated LuFeO3 particles. The addition of ethanol leads to a quenching of •OH radicals, whereas the yield of •OH radicals is highly increased on addition of OA. Based on the experimental results, •OH radicals are suggested to be the dominant active species responsible for the dye degradation, while superoxide (•O2-) radicals play a negligible role in the photocatalysis.

  15. The melting behavior of lutetium aluminum perovskite LuAlO3

    NASA Astrophysics Data System (ADS)

    Klimm, Detlef

    2010-02-01

    DTA measurements with mixtures of aluminum oxide and lutetium oxide around the 1:1 perovskite composition were performed up to 1970C. A peak with onset 1901C was due to the melting of the eutectic Lu4Al2O9 (monoclinic phase) and LuAlO3 (perovskite). Neither peritectic melting of the perovskite nor its decomposition in the solid phase could be resolved experimentally. The maximum of the eutectic peak size is near x=0.44, on the Lu-rich side of the perovskite, which is consistent with the conclusion that LuAlO3 melts peritectically at ca. 1907C as proposed by Wu, Pelton, J. Alloys Compd. 179 (1992) 259. Thermodynamic equilibrium calculation reveals that under strongly reducing conditions (oxygen partial pressure <10-13 bar) aluminum(III) oxide can be reduced to suboxides or even Al metal. It is shown that under such conditions a new phase field with liquid Al can appear.

  16. Lu, Altman and Morukov work on TVIS in Zvezda during STS-106

    NASA Image and Video Library

    2000-09-16

    STS106-373-004 (8-20 September 2000) --- Three members of the STS-106 crew move the treadmill device. They are (counterclockwise from bottom) astronaut Edward T. Lu and cosmonaut Boris V. Morukov, both mission specialists, along with astronaut Scott D. Altman, pilot.

  17. Bright Lu2O3:Eu thin-film scintillators for high-resolution radioluminescence microscopy

    PubMed Central

    Sengupta, Debanti; Miller, Stuart; Marton, Zsolt; Chin, Frederick; Nagarkar, Vivek

    2015-01-01

    We investigate the performance of a new thin-film Lu2O3:Eu scintillator for single-cell radionuclide imaging. Imaging the metabolic properties of heterogeneous cell populations in real time is an important challenge with clinical implications. We have developed an innovative technique called radioluminescence microscopy, to quantitatively and sensitively measure radionuclide uptake in single cells. The most important component of this technique is the scintillator, which converts the energy released during radioactive decay into luminescent signals. The sensitivity and spatial resolution of the imaging system depend critically on the characteristics of the scintillator, i.e. the material used and its geometrical configuration. Scintillators fabricated using conventional methods are relatively thick, and therefore do not provide optimal spatial resolution. We compare a thin-film Lu2O3:Eu scintillator to a conventional 500 μm thick CdWO4 scintillator for radioluminescence imaging. Despite its thinness, the unique scintillation properties of the Lu2O3:Eu scintillator allow us to capture single positron decays with over fourfold higher sensitivity, a significant achievement. The thin-film Lu2O3:Eu scintillators also yield radioluminescence images where individual cells appear smaller and better resolved on average than with the CdWO4 scintillators. Coupled with the thin-film scintillator technology, radioluminescence microscopy can yield valuable and clinically relevant data on the metabolism of single cells. PMID:26183115

  18. Bright Lu2 O3 :Eu Thin-Film Scintillators for High-Resolution Radioluminescence Microscopy.

    PubMed

    Sengupta, Debanti; Miller, Stuart; Marton, Zsolt; Chin, Frederick; Nagarkar, Vivek; Pratx, Guillem

    2015-07-16

    The performance of a new thin-film Lu2 O3 :Eu scintillator for single-cell radionuclide imaging is investigated. Imaging the metabolic properties of heterogeneous cell populations in real time is an important challenge with clinical implications. An innovative technique called radioluminescence microscopy has been developed to quantitatively and sensitively measure radionuclide uptake in single cells. The most important component of this technique is the scintillator, which converts the energy released during radioactive decay into luminescent signals. The sensitivity and spatial resolution of the imaging system depend critically on the characteristics of the scintillator, that is, the material used and its geometrical configuration. Scintillators fabricated using conventional methods are relatively thick and therefore do not provide optimal spatial resolution. A thin-film Lu2 O3 :Eu scintillator is compared to a conventional 500 μm thick CdWO4 scintillator for radioluminescence imaging. Despite its thinness, the unique scintillation properties of the Lu2 O3 :Eu scintillator allow us to capture single-positron decays with fourfold higher sensitivity, which is a significant achievement. The thin-film Lu2 O3 :Eu scintillators also yield radioluminescence images where individual cells appear smaller and better resolved on average than with the CdWO4 scintillators. Coupled with the thin-film scintillator technology, radioluminescence microscopy can yield valuable and clinically relevant data on the metabolism of single cells. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. A deeper insight into (Lu,Y)AG:Pr scintillator crystals

    NASA Astrophysics Data System (ADS)

    Drozdowski, W.; Wojtowicz, A. J.; Brylew, K.; Łachmański, W.; Talik, E.; Szubka, M.; Kusz, J.; Guzik, A.; Balin, K.; Kisielewski, J.; Świrkowicz, M.; Pajączkowska, A.

    2017-02-01

    Interior of Czochralski-grown (Lu,Y)AG:Pr crystals has been examined by means of several techniques, such as X-Ray Photoelectron Spectroscopy, X-Ray Diffraction, Time-of-Flight Secondary Ion Mass Spectrometry, and magnetic susceptibility measurements. Additionally, their luminescence has been monitored at various combinations of a double-beam (X-ray/IR) excitation.

  20. LU Factorization with Partial Pivoting for a Multi-CPU, Multi-GPU Shared Memory System

    SciTech Connect

    Kurzak, Jakub; Luszczek, Pitior; Faverge, Mathieu; Dongarra, Jack

    2012-03-01

    LU factorization with partial pivoting is a canonical numerical procedure and the main component of the High Performance LINPACK benchmark. This article presents an implementation of the algorithm for a hybrid, shared memory, system with standard CPU cores and GPU accelerators. Performance in excess of one TeraFLOPS is achieved using four AMD Magny Cours CPUs and four NVIDIA Fermi GPUs.

  1. Efficient Operation of Conductively Cooled Ho:Tm:LuLiF Laser Oscillator/Amplifier

    NASA Technical Reports Server (NTRS)

    Yu, Jirong; Bai, Yingxin; Trieu, Bo; Petros, M.; Petzar, Paul; Lee, Hyung; Singh, U.

    2008-01-01

    A conductively-cooled Ho:Tm:LuLiF laser oscillator generates 1.6J normal mode pulses at 10Hz with optical to optical efficiency of 20%. When the laser head module is used as the amplifier, the double-pass small-signal amplification excesses 25.

  2. An Exploration of Structures in the Transitional Odd-Odd Nucleus Lu-160

    DTIC Science & Technology

    2015-05-18

    employed to capture information about the high- energy photons. Experimental evidence showed abnormal signature splitting behavior in Lu-160. We...13 8 Shell model energy levels . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 9...22 14 Quasiparticle energy levels . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 15 Coriolis effect in time-reversed orbits

  3. Three-phonon stimulated Raman scattering in an orthorhombic LuAlO3 crystal

    NASA Astrophysics Data System (ADS)

    Kaminskii, A. A.

    2016-12-01

    High-order stimulated Raman scattering (SRS) has been revealed in a LuAlO3 crystal upon stationary picosecond laser excitation. All recorded Stokes and anti-Stokes χ(3)-nonlinear laser components are attributed to three SRS-promoting A g vibrational modes of its octahedral anionic units (AlO3)-3.

  4. Transport properties of Ho1- x Lu x B12 solid solutions

    NASA Astrophysics Data System (ADS)

    Gabáni, S.; Bat'ko, I.; Bat'ková, M.; Flachbart, K.; Gaz̆o, E.; Pristás̆, G.; Takác̆ová, I.; Bogach, A. V.; Sluchanko, N. E.; Shitsevalova, N. Yu.

    2013-05-01

    Our studies of Ho1- x Lu x B12 solid solutions have shown that the temperature of antiferromagnetic (AF) order in geometrically frustrated system of HoB12 ( T N = 7.4 K) is linearly suppressed to zero temperature, i.e. T N → 0, as lutetium concentration increases to x→ x c ≈ 0.9. In this contribution, we present original results of electrical resistivity measurements on Ho1- x Lu x B12 single crystalline samples with x = 0, 0.2, 0.5, 0.7, 0.9, 1 in the temperature range 0.06-300 K and in magnetic fields ( B) up to 8 T. Complex B vs T N phase diagrams were received from precise temperature ρ( T) and field ρ( B) dependences of resistivity with several AF phases for x ≤ 0.5 pointing to a possibility of quantum critical point at x c ≈ 0.9. The scattering of conduction electrons in the AF phase and in the paramagnetic phase as well as Hall effect results are analyzed and discussed for various concentrations x, when magnetic dilution increases with the increasing content of nonmagnetic Lu ions in the Ho1- x Lu x B12 system.

  5. Tm:YLF Pumped Ho:YAG and Ho:LuAG Lasers

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.; Reichle, Donald J.; Walsh, Brian M.; Axenson, Theresa J.

    2004-01-01

    Room temperature Ho:YAG and Ho:LuAG lasers pumped by a Tm:YLF laser demonstrated a 3.4 mJ threshold and 0.41 slope efficiency, incident optical to laser output energy. Results for numerous rod lengths, Ho concentrations, and output mirror reflectivities are presented.

  6. Orthopaedic techniques of Sabuncuoğlu in the 15th century Ottoman period.

    PubMed

    Sarban, Sezgin; Aksoy, Sahin; Uzel, Ilter; Işikan, Uğur E; Atik, Sahap

    2005-10-01

    Serefeddin Sabuncuoğlu (1385-1468) was the author of the surgical textbook Cerrahiyyetü'l-Haniyye (Imperial Surgery). It was the first illustrated surgical textbook in the Turkish-Islamic medical literature. Cerrahiyyetü'l-Haniyye is significant because it includes Sabuncuoğlu's color illustrations of surgical procedures, incisions, fracture dislocation reduction techniques, and instruments. There are only three handwritten copies. Two originally were written by Sabuncuoğlu and are exhibited in Paris and Istanbul. The book was rediscovered in 1936, but some parts are suspected to be missing. The book currently consists of three chapters divided into 193 sections. The third chapter includes orthopaedics and traumatology, reduction techniques of lower and upper extremities, fractures and dislocations, and relevant Greek, Arabic, and Persian textbooks are cited. Sabuncuoğlu also wrote about surgical treatment of congenital hand anomalies. He was the first to advise placing a wooden splint under the palmar side after hand surgery. We reviewed the sections of Cerrahiyyetü'l-Haniyye related to orthopaedics and traumatology. Compared with previous writings by Hippocrates, Ibn-i Sina, and Al-Zahrawi, there are no major differences in the treatment of fracture dislocations.

  7. Camptothecin Enhances Cell Death Induced by (177)Lu-EDTMP in Osteosarcoma Cells.

    PubMed

    Kumar, Chandan; Vats, Kusum; Lohar, Sharad P; Korde, Aruna; Samuel, Grace

    2014-10-01

    Lutetium-177 is an assured therapeutic radionuclide with favorable half-life and suitable β(-) energy. Radiolabeled (177)Lu-EDTMP (Ethylenediamine tetramethylene phosphonic acid) is by and large used for bone pain palliation in cancer patients. In vitro cell studies are carried out in osteosarcoma cells MG-63 to evaluate the combined effect of anticancer drug camptothecin (CPT) and (177)Lu-EDTMP. Two concentrations of (177)Lu-EDTMP (3.7 and 37 MBq) were incubated with MG63 cell line for 48 hours with and without pretreatment of CPT (10 nM) for 1 hour. After completion of incubation, the cells were harvested and cellular toxicity was estimated by LDH, MTT, and trypan blue dye. Apoptotic DNA fragmentation was estimated by ELISA kit. The expression of proteins such as bcl2, PARP, and MAPK (mitogen-activated protein kinase) that were related to apoptotic signaling pathways was assessed by western blotting. The results indicated that cellular toxicity and apoptosis were relatively higher in MG63 cells that were treated with CPT prior to treating with (177)Lu-EDTMP in comparison with the corresponding individual controls.

  8. Expedition Seven CDR Malenchenko and Science Officer Lu in Zvezda module

    NASA Image and Video Library

    2003-06-22

    ISS007-E-07897 (22 June 2003) --- Astronaut Edward T. Lu (at musical keyboard), Expedition 7 NASA ISS science officer and flight engineer, and cosmonaut Yuri I. Malenchenko, mission commander, share a light moment during off-shift time in the Destiny laboratory on the International Space Station (ISS). Malenchenko represents Rosaviakosmos.

  9. CW and tunable performances of Yb3+:LuAG transparent ceramics with different doping concentrations

    NASA Astrophysics Data System (ADS)

    Ma, Chaoyang; Zhu, Jiangfeng; Liu, Kai; Wen, Zicheng; Ma, Ran; Long, Jiaqi; Yuan, Xuanyi; Cao, Yongge

    2017-07-01

    We report the CW laser operation and wavelength tunability of 10 at%, 15 at% and 20 at% Yb3+-doping LuAG ceramics pumped at 970 nm. The absorption saturation effects were taken into account herein. For 10 at% Yb3+-doping sample, the maximum slop efficiency and output power was 60.7% and 1.8 W, respectively. Furthermore, the slop efficiencies of 52.3% (15 at%) and 46.5% (20 at%) were reported. What's more, the maximum optical-to-optical efficiency for our samples was determined to be 40.1%, 36.8%, and 33.1% at the incident pump power of 4 W, respectively. The round-trip cavity loss of the laser system based on our Yb3+:LuAG ceramics were evaluated. The tuning curve of a 20 at% Yb3+:LuAG ceramic extended from 1018 nm up to 1062 nm, and that of 10 at% and 15 at% samples became much more broader, making Yb3+:LuAG ceramics possible candidates for ultrashort pulse generation.

  10. Forward to cryogenic temperature: laser cooling of Yb: LuLiF crystal

    NASA Astrophysics Data System (ADS)

    Zhong, Biao; Luo, Hao; Lei, Yongqing; Shi, Yanling; Yin, Jianping

    2017-06-01

    The high quality Yb-doped fluoride crystals have broad prospects for optical refrigeration. We have laser cooled the Yb:LuLiF crystal to a temperature below the limit of current thermoelectric coolers ( 180 K). The 5% Yb:LuLiF crystal sample has a geometry of 2 mm×2 mm×5 mm and was supported by two fibers of 200 μm in diameter. They were placed in a 2×10-4 Pa vacuum chamber with an environment temperature of 294.5 K. The 1019 nm CW laser of power 38.7 W was adopted to irradiate the sample. The temperature of the sample was measured utilizing the DLT methods. After 20 minutes of laser irradiation, the 5% Yb:LuLiF crystal sample was cooled down to 182.4 K. By further optimizing experimental conditions and increasing the doped Yb concentration, the Yb:LuLiF crystal might be optically cooled below the cryogenic temperature of 123K in the near future.

  11. A New World: Redefining the Legacy of Min-Zhan Lu

    ERIC Educational Resources Information Center

    Ray, Brian

    2008-01-01

    This article discusses exchanges between a number of scholars during the 1990s centering on Min-Zhan Lu's controversial essay "Conflict and Struggle: The Enemies or Preconditions of Basic Writing?" In some ways, "Conflict and Struggle" blazed a trail for later work in "hybrid" or "mixed" forms of academic writing while at the same time igniting…

  12. Enhanced local lattice distortions with the antiferromagnetic transition in the multiferroic LuMnO3

    NASA Astrophysics Data System (ADS)

    Louca, Despina; Proffen, Thomas; Lee, Seung-Hun; Cheong, Sang-Wook

    2009-03-01

    The ferroelectric hexagonal manganite, LuMnO3, has been investigated via neutron scattering and the pair density function analysis to determine the nature of the local atomic distortions with the antiferromagnetic transition, TN, of the Mn ions. While in previously reported neutron diffraction data, it was shown that all atomic coordinates changed based on symmetry considerations with TN, we hereby show that it is the ferroelectric motion of the Lu ions coupled with O distortions that exhibits a strong temperature dependence below TN as reflected in the Lu-O bonds. This suggests an enhancement of the net electric polarization below TN. At the same time, the motion of the apical O1 and O2 ions distorts the MnO5 bipyramids, leading to more buckling of the ab-layers. However, the Mn ions do not appear to distort significantly away from their equilibrium position. The oxygen distortions induced with the spin reorientations below TN may be the cause for the Lu ion displacements through electrostatic interactions and this in turn produces coupling to the electric dipole moments.

  13. Disorder-sensitive superconductivity in the doped iron silicide superconductor (Lu1-xRx)2Fe3Si5 ( R=Sc , Y, and Dy)

    NASA Astrophysics Data System (ADS)

    Watanabe, Tadataka; Sasame, Hiroki; Okuyama, Hiroaki; Takase, Kouichi; Takano, Yoshiki

    2009-09-01

    We studied the effect of nonmagnetic and magnetic impurities on superconductivity in Lu2Fe3Si5 by small-amount substitution of the Lu site and investigated structural, magnetic, and electrical properties of nonmagnetic (Lu1-xScx)2Fe3Si5 , (Lu1-xYx)2Fe3Si5 , and magnetic (Lu1-xDyx)2Fe3Si5 . The rapid depression of Tc by nonmagnetic impurities in accordance with the increase in the residual resistivity reveals the strong pair breaking dominated by disorder.

  14. Structural, microstructural and vibrational analyses of the monoclinic tungstate BiLuWO{sub 6}

    SciTech Connect

    Ait Ahsaine, H.; Taoufyq, A.; Patout, L.; Ezahri, M.; Benlhachemi, A.; Bakiz, B.; Villain, S.; Guinneton, F.; Gavarri, J.-R.

    2014-10-15

    The bismuth lutetium tungstate phase BiLuWO{sub 6} has been prepared using a solid state route with stoichiometric mixtures of oxide precursors. The obtained polycrystalline phase has been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Raman spectroscopy. In the first step, the crystal structure has been refined using Rietveld method: the crystal cell was resolved using monoclinic system (parameters a, b, c, β) with space group A2/m. SEM images showed the presence of large crystallites with a constant local nominal composition (BiLuW). TEM analyses showed that the actual local structure could be better represented by a superlattice (a, 2b, c, β) associated with space groups P2 or P2/m. The Raman spectroscopy showed the presence of vibrational bands similar to those observed in the compounds BiREWO{sub 6} with RE=Y, Gd, Nd. However, these vibrational bands were characterized by large full width at half maximum, probably resulting from the long range Bi/Lu disorder and local WO{sub 6} octahedron distortions in the structure. - Graphical abstract: The average structure of BiLuWO{sub 6} determined from X-ray diffraction data can be represented by A2/m space group. Experimental Electron Diffraction patterns along the [0vw] zone axes of the monoclinic structure and associated simulated patterns show the existence of a monoclinic superstructure with space group P2 or P2/m. - Highlights: • A new monoclinic BiLuWO{sub 6} phase has been elaborated from solid-state reaction. • The space group of the monoclinic disordered average structure should be A2/m. • Transmission electron microscopy leads to a superlattice with P2/m space group. • Raman spectroscopy suggests existence of local disorder.

  15. Thermal, vibrational and optical properties of PrLuO3 interlanthanides from hydrothermally-derived precursors.

    PubMed

    Soares, Júlia C; Siqueira, Kisla P F; de Sousa Filho, Paulo C; Moreira, Roberto L; Dias, Anderson

    2017-01-17

    PrLuO3 interlanthanides were prepared at temperatures ranging from 800 °C to 1600 °C using hydrothermally-derived precursors. The chemical reactions observed include the conversion and segregation of Pr(OH)3 and LuO(OH), respectively, into PrO2 and Lu2O3 cubic oxides below 1200 °C, followed by the production of a mixture of hexagonal P63/mmc and orthorhombic Pnma PrLuO3 phases at 1400 °C. Phase-pure orthorhombic PrLuO3 was obtained at 1600 °C, which was corroborated by Raman and micro far-infrared spectroscopic analyses. Photoluminescence, colorimetric and lifetime measurements were carried out in PrLuO3 samples. Dominant emission verified in samples calcined at 1400 °C corresponds to the hypersensitive (3)P0 → (3)F2 transition with a color purity of 97% (decay times of 12 μs and 3 μs), while emissions for the phase-pure samples correspond to the (3)P0 → (3)H6 and (3)P0 → (3)H5 transitions with a color purity of 94% (a single luminescence lifetime of 12 μs). The optical properties of PrLuO3 interlanthanides thereby suggest that they can be used as luminescent materials in both structural arrangements.

  16. AKAP-dependent modulation of BCAM/Lu adhesion on normal and sickle cell disease RBCs revealed by force nanoscopy.

    PubMed

    Maciaszek, Jamie L; Andemariam, Biree; Abiraman, Krithika; Lykotrafitis, George

    2014-03-18

    Human normal and sickle red blood cells (RBCs) adhere with high affinity to the alpha5 chain of laminin (LAMA5) via the basal cell adhesion molecule/Lutheran (BCAM/Lu) receptor, which is implicated in vasoocclusive episodes in sickle cell disease and activated through the cyclic adenosine monophosphate (cAMP) signaling pathway. However, the effect of the cAMP pathway on the expression of active BCAM/Lu receptors at the single-molecule level is unknown. We established an in vitro technique, based on atomic force microscopy, which enables detection of single BCAM/Lu proteins on the RBC surface and measures the unbinding force between BCAM/Lu and LAMA5. We showed that the expression of active BCAM/Lu receptors is higher in homozygous sickle RBCs (SS-RBCs) than normal RBCs and that it is critically dependent on the cAMP signaling pathway on both normal and SS-RBCs. Of importance, we illustrated that A-kinase anchoring proteins are crucial for BCAM/Lu receptor activation. Furthermore, we found that SS-RBCs from hydroxyurea-treated patients show a lower expression of active BCAM/Lu receptors, a lower unbinding force to LAMA5, and insignificant stimulation by epinephrine as compared to SS-RBCs from untreated patients. To our knowledge, these findings may lead to novel antiadhesive targets for vasoocclusive episodes in sickle cell disease.

  17. Luminescent LuVO4:Ln3+ (Ln = Eu, Sm, Dy, Er) hollow porous spheres for encapsulation of biomolecules

    NASA Astrophysics Data System (ADS)

    Li, Dan; Liu, Chunlei; Jiang, Lianzhou

    2015-10-01

    In this study, LuVO4:Ln3+ (Ln = Eu, Sm, Dy, Er) hollow porous spheres, synthesized via self-sacrificing templated route, are developed for enzyme immobilization and protein adsorption. The four LuVO4 hollow spheres with diameter of 180 nm, 280 nm, 370 nm and 480 nm were obtained. The size of LuVO4 hollow sphere is dependent on Lu(OH)CO3 template. Upon excitation by UV light, hollow LuVO4:Ln3+ (Ln = Eu, Sm, Dy, Er) spheres exhibit red (Eu3+), orange (Sm3+), yellow-green (Dy3+), and green (Er3+) emissions. The good biocompatibility of sample is validated by MTT assay. Due to structure feature and size of obtained sample, the rapid encapsulation of biomolecules within samples has been achieved. Furthermore, the hollow spheres show different biomolecules adsorption capacities at different buffer solution pH values. The release behaviors of two kinds of biomolecules (lysozyme and bovine serum albumin) are also investigated. LuVO4 hollow spheres are suitable carriers for biomolecules. The emission intensity of Eu3+ in the LuVO4:Eu3+ varies with the released amount of LYZ. This enables the monitoring of release process by the change in the luminescence intensity.

  18. Comparison of structural and electrical properties of Lu{sub 2}O{sub 3} and Lu{sub 2}TiO{sub 5} gate dielectrics for α-InGaZnO thin-film transistors

    SciTech Connect

    Pan, Tung-Ming Chen, Ching-Hung; Her, Jim-Long; Koyama, Keiichi

    2014-11-21

    We compared the structural properties and electrical characteristics of high-κ Lu{sub 2}O{sub 3} and Lu{sub 2}TiO{sub 5} gate dielectrics for amorphous indium-gallium-zinc oxide (α-InGaZnO) thin-film transistor (TFT) applications. The Lu{sub 2}O{sub 3} film has a strong Lu{sub 2}O{sub 3} (400) peak in the X-ray diffraction pattern, while the Lu{sub 2}TiO{sub 5} sample shows a relatively weak Lu{sub 2}TiO{sub 5} (102) peak. Atomic force microscopy reveals that the Lu{sub 2}O{sub 3} dielectric exhibits a rougher surface (about three times) than Lu{sub 2}TiO{sub 5} one. In X-ray photoelectron spectroscopy analysis, we found that the intensity of the O 1s peak corresponding to Lu(OH){sub x} for Lu{sub 2}O{sub 3} film was higher than that of Lu{sub 2}TiO{sub 5} film. Furthermore, compared with the Lu{sub 2}O{sub 3} dielectric, the α-InGaZnO TFT using the Lu{sub 2}TiO{sub 5} gate dielectric exhibited a lower threshold voltage (from 0.43 to 0.25 V), a higher I{sub on}/I{sub off} current ratio (from 3.5 × 10{sup 6} to 1.3 × 10{sup 8}), a smaller subthreshold swing (from 276 to 130 mV/decade), and a larger field-effect mobility (from 14.5 to 24.4 cm{sup 2}/V s). These results are probably due to the incorporation of TiO{sub x} into the Lu{sub 2}O{sub 3} film to form a Lu{sub 2}TiO{sub 5} structure featuring a smooth surface, a low moisture absorption, a high dielectric constant, and a low interface state density at the oxide/channel interface. Furthermore, the stability of Lu{sub 2}O{sub 3} and Lu{sub 2}TiO{sub 5} α-InGaZnO TFTs was investigated under positive gate-bias stress (PGBS) and negative gate-bias stress (NGBS). The threshold voltage of the TFT performed under NGBS is more degradation than that under PGBS. This behavior may be attributed to the electron charge trapping at the dielectric–channel interface under PGBS, whereas the oxygen vacancies occurred in the InGaZnO under NGBS.

  19. Tuning of structure and enhancement of upconversion luminescence in NaLuF4:Yb(3+),Ho(3+) crystals.

    PubMed

    Lin, Hao; Xu, Dekang; Li, Anming; Teng, Dongdong; Yang, Shenghong; Zhang, Yueli

    2015-07-15

    A series of NaLuF4:Yb(3+),Ho(3+) nano/micro-crystals with different crystal structures were synthesized via a hydrothermal method using citric acid as a chelating agent. The influences of NaF content, Li(+) doping, reaction temperature and reaction time on the crystal structure and shape of the as-synthesized NaLuF4 crystals were systematically investigated. To the best of our knowledge, it is the first time to report Li(+) doped α-NaLuF4:Yb(3+),Ho(3+) nanocrystals and the phase transformation by introducing Li(+) in NaLuF4 crystals. As for Li(+) doped α-NaLuF4, UC luminescence intensities of green emission (538 nm) and red emission (644 nm) in α-NaLuF4:Yb(3+),Ho(3+) nanocrystals with 20 mol% Li(+) doping are enhanced by 20 and 3.5 times compared to their Li(+)-free counterpart. As for Li(+) doped α/β-mixed NaLuF4, with the increase of Li(+) content, the phase transforms from the α/β-mixed phase to hexagonal then to cubic. UC emissions of 538 nm and 644 nm in NaLuF4:Yb(3+),Ho(3+) crystals doped with 5 mol% Li(+) are enhanced by 26.5 and 23 times, respectively. Besides, it is found that with the higher temperature and prolonged time, the morphology of NaLuF4 changes from nanoparticles to microtubes, resulting in the dramatic increase of UC emission intensity. The effects of Li(+) doping, reaction temperature and reaction time on the enhancement of UC emission intensity are discussed in detail. This study provides an effective and facile approach to obtain nano/micro-crystals with controllable structures and excellent optical properties.

  20. Reducing renal uptake of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues

    SciTech Connect

    Miao, Yubin; Fisher, Darrell R.; Quinn, Thomas P.

    2006-06-15

    The purpose of this study was to improve the tumor-to-kidney uptake ratios of 90Y- and 177Lu-[1,2,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-Re-Cys,D-Phe,Arg]alpha-melanocyte stimulating hormone (DOTA-RE(Arg)CCMSH), through coupling a negatively charged glutamic acid (Glu) to the peptide sequence. A new peptide of DOTA-Re(Glu,Arg)CCMSH was designed, synthesized and labeled with 90Y and 177Lu. Pharmacokinetics of 90Y- and 177Lu-DOTA-RE(Glu,Arg)CCNSH were determined in B16/F1 murine melanoma-bearing C57 mice. Both exhibited significantly less renal uptake than 90Y- and 177Lu-DOTA-Re(Arg)CCMSH at 30 min and at 2, 3, and 24 h after dose administration. The renal uptake values of 90Y- and 177Lu-DOTA-Re(Glu,Arg)CCMSH were 28.16% and 28.81% of those of 90Y- and 177Lu-DOTA-RE(Arg)CCMSH, respectively, at 4 hr post-injection. We also showed higher tumor-to-kidney uptake ratios 2.28 and 1.69 times that of 90Y- and 177Lu-DOTA-Re(Arg)CCMSH, respectively, at 4 h post-injection. The90Y- and 177Lu-DOTA-Re(Glu,Arg)CCMSH activity accumulation was low in normal organs except for kidneys. Coupling a negatively charged amino acid (Glu) to the CCMSH peptide sequence dramatically reduced the renal uptake values and increased the tumor-to-kidney uptake ratios of 90Y- and 177Lu-DOTA-Re(Glu,Arg)CCMSH, facilitating their potential applications as radiopharmaceuticals for targeted radionuclide therapy of melanoma.

  1. Positive Influence of 177Lu PSMA-617 Therapy on Bone Marrow Depression Caused by Metastatic Prostate Cancer.

    PubMed

    Schlenkhoff, Carl Diedrich; Gaertner, Florian; Essler, Markus; Schmidt, Matthias; Ahmadzadehfar, Hojjat

    2016-06-01

    A 75-year-old man with castrate-resistant prostate cancer and increasing prostate-specific antigen (PSA) level developed severe bone marrow depression during Ra radionuclide therapy. Because of this, he was treated with Lu-PSMA in compassionate use for this not-yet-approved therapy. At the beginning of Lu-PSMA therapy, repeated blood transfusions (BT) were necessary. Six months after the last BT, after 3 cycles of Lu-PSMA, his blood count stabilized. He required no further BTs and his PSA level remained lowered.

  2. Magnetic transition anisotropies in orthorhombic LuMnO3 and HoMnO3 multiferroic thin films

    NASA Astrophysics Data System (ADS)

    Tsai, T. Y.; Lin, T. H.; Slowry, S.; Luo, C. W.; Wu, K. H.; Lin, J.-Y.; Uen, T. M.; Juang, J. Y.

    2010-01-01

    We have successfully prepared the b-axis-oriented orthorhombic LuMnO3 (LuMO) and HoMnO3 (HMO) thin films by pulsed laser deposition on (110)-LaAlO3 substrates. The nearly perfect alignment between the film growth orientation and the substrate allows us to study the magnetic transitions along the respective crystal orientation, which has displayed marked anisotropic behaviours. In particular, with the largest ionic size difference between Lu and Ho for the family of RMnO3 displaying the E-type AFM, the effects of lattice distortion on the magnetic transition are compared.

  3. The Lu-Hf isotopic composition of CHUR and BSE: Tighter constraints from unequilibrated chondrites

    NASA Astrophysics Data System (ADS)

    Bouvier, A.; Vervoort, J. D.; Patchett, J.

    2007-12-01

    The Lu-Hf isotopic system has been used increasingly in geochemistry as a chronometer and tracer of mantle and crust processes since the development of MC-ICPMS techniques [1]. Although a consensus has emerged on the value of the 176Lu decay constant, in contrast, the Lu and Hf isotopic compositions of the Chondrite Uniform Reservoir (CHUR) and Bulk Silicate Earth (BSE) have not been as well constrained. Lu-Hf isotopic compositions vary dramatically between the chondrite classes and petrologic types of the specimens that have been analyzed [1-3], which hampers a choice of Lu-Hf CHUR parameters. Chondrites are classified in three main petrologic groups: carbonaceous (CC), ordinary (OC) and enstatite chondrites (EC). They represent distinct chemical and isotopic compositions, which can be associated with reservoirs in the protoplanetary disk where the respective parent bodies have formed. They also have been subjected to various degrees of aqueous alteration (types 1 and 2) or thermal metamorphism (types 3-6) that has potentially affected their initial chemical and mineralogical characteristics. Despite the fact that numerous OCs (~50) have been analyzed for their Lu-Hf isotopic composition, nearly all of these have been equilibrated types 4-6; only 5 finds of types 3.6-3.8 unequilibrated OC have been analyzed. We have analyzed 20 new chondrites for Lu-Hf and Sm-Nd isotope systematics including (i) 13 H, L, and LL OC of types 3.0- 3.8, where their low degree of metamorphism limits the growth of phosphate (main carrier of REE) compared to the equilibrated OC; and (ii) 7 CC of types 1-3 (CI, CV, CO and CK groups). We obtained mean values (2σSE) of 176Lu/177Hf = 0.0337 ± 3, 176Hf/177Hf = 0.282802 ± 23, 147Sm/144Nd = 0.1961 ± 6, and 143Nd/144Nd = 0.512629 ± 16 from the types 1-3 OC and CC from this study and [2]. Our Lu-Hf values are higher than the previous estimates of [3] and are our best estimates for CHUR. The CC alone give higher mean values of 176Lu/177Hf

  4. Lu-Hf isotope systematics of the Hadean-Eoarchean Acasta Gneiss Complex (Northwest Territories, Canada)

    NASA Astrophysics Data System (ADS)

    Guitreau, Martin; Blichert-Toft, Janne; Mojzsis, Stephen J.; Roth, Antoine S. G.; Bourdon, Bernard; Cates, Nicole L.; Bleeker, Wouter

    2014-06-01

    The Acasta Gneiss Complex (AGC) is a remnant Hadean-Eoarchean terrane composed of strongly deformed polyphase mafic to felsic gneisses which preserve a multi-stage history of magmatic emplacement, inheritance, and subsequent tectono-thermal modifications. The complexities encountered in such an old terrane fragment have been documented in previous geochronological studies of the AGC (e.g. zircon U-Pb, 147Sm-143Nd), and are evident also in its Lu-Hf isotope systematics. Here, we report new Lu-Hf isotope whole-rock measurements which show that some AGC gneisses were severely disturbed by migmatization and associated mineral segregation, while others preserve their Lu-Hf isotope systematics relatively intact with mostly near- to sub-chondritic initial 176Hf/177Hf ratios. Results reveal identifiable Eoarchean and later (Paleoarchean) magmatic events at around 3960 Ma and again at 3600 Ma, with a major metamorphism of the complex at 3750 Ma. The oldest and least disturbed gneisses have a Lu-Hf regression age of 3946 ± 87 Ma, in good agreement with U-Pb zircon geochronology. A role of yet older crust (4000-4200 Ma) in the formation of the AGC is also evident, but seems not to have influenced to first order the Lu-Hf isotope systematics of the 3960 Ma group. The ca. 3960 Ma group is proposed to be representative of its mantle source based on the absence of correlation between εHf(t) and Ce/Pb. It is further suggested that these two parameters show that the ca. 3600 Ma gneisses were sourced in part from a mafic lithology belonging to the 3960 Ma group, and that multiple sources (mantle and crust) were involved in AGC formation. The identification of preserved Lu-Hf isotope systematics in AGC gneisses means that complementary geochemical and isotopic studies bearing on the petrogenesis of pre-3900 Ma rocks are possible. Despite its history of strong deformation and alteration, carefully selected domains within the AGC carry surviving information about the evolution of the

  5. 1.88 Micrometers InGaAsP Pumped, Room Temperature Ho: LuAG Laser

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.; Amzajerdian, Farzin; Reichle, Donald J.; Busch, George; Leisher, Paul

    2009-01-01

    A room temperature, directly diode pumped Ho:LuAG laser oscillated for the first time. Direct pumping of the Ho upper laser manifold maximizes efficiency, minimizes heating, and eliminates Ho:Tm energy sharing. Design and performance are presented.

  6. [177Lu-PSMA-617 therapy, dosimetry and follow-up in patients with metastatic castration-resistant prostate cancer].

    PubMed

    Fendler, Wolfgang P; Kratochwil, Clemens; Ahmadzadehfar, Hojjat; Rahbar, Kambiz; Baum, Richard P; Schmidt, Matthias; Pfestroff, Andreas; Lützen, Ulf; Prasad, Vikas; Heinzel, Alexander; Heuschkel, Martin; Ruf, Juri; Bartenstein, Peter; Krause, Bernd J

    2016-06-28

    Radioligand therapy (RLT) using 177Lu labelled inhibitors of the prostate-specific membrane antigen (177Lu-PSMA) is performed in patients with metastatic castration-resistant prostate cancer (mCRPC) after exhaustion of other options. German University Clinics offer RLT since 2013 on a compassionate use basis. The present consensus document includes recommendations for RLT with 177Lu-PSMA-617. These consensus statements were developed by an expert panel formed by the German Society of Nuclear Medicine (DGN) in December 2015. Statements include recommendations for indication, baseline tests, therapy protocol, concomitant therapy, dosimetry, and follow-up. Consensus recommendations aim to inform the attending medical staff, standardize 177Lu-PSMA-617 RLT, and improve quality of individual patient care.

  7. Peculiarities in the Raman spectra of ZrB{sub 12} and LuB{sub 12} single crystals

    SciTech Connect

    Werheit, H. . E-mail: helmut.werheit@koeln.de; Paderno, Yu.; Filippov, V.; Paderno, V.; Pietraszko, A.; Armbruester, M.; Schwarz, U.

    2006-09-15

    We have measured Raman spectra of high-quality Zr{sup nat}B{sub 12}, Lu{sup nat}B{sub 12} and Lu{sup 11}B{sub 12} single crystals with high resolution, and the observed strong peaks are attributed to specific vibration modes. Besides, there are a number of additional Raman peaks in spectral ranges, where only Raman-inactive vibrations of the atomic arrangement are expected. Accordingly, it is assumed, that the investigated crystals contain intrinsic structural imperfections or distortions in sufficient concentration and efficiency to initiate the observed breaking of phonon selection rules. We suppose boron vacancies, boron isotope effects and displacements of the metal atoms to be reasons for such imperfections. - Graphical abstract: Raman spectra of Lu{sup nat}B{sub 12}, Lu{sup 11}B{sub 12} and Zr{sup nat}B{sub 12}.

  8. 1.88 Micrometers InGaAsP Pumped, Room Temperature Ho: LuAG Laser

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.; Amzajerdian, Farzin; Reichle, Donald J.; Busch, George; Leisher, Paul

    2009-01-01

    A room temperature, directly diode pumped Ho:LuAG laser oscillated for the first time. Direct pumping of the Ho upper laser manifold maximizes efficiency, minimizes heating, and eliminates Ho:Tm energy sharing. Design and performance are presented.

  9. Calculations of steady and transient channel flows with a time-accurate L-U factorization scheme

    NASA Technical Reports Server (NTRS)

    Kim, S.-W.

    1991-01-01

    Calculations of steady and unsteady, transonic, turbulent channel flows with a time accurate, lower-upper (L-U) factorization scheme are presented. The L-U factorization scheme is formally second-order accurate in time and space, and it is an extension of the steady state flow solver (RPLUS) used extensively to solve compressible flows. A time discretization method and the implementation of a consistent boundary condition specific to the L-U factorization scheme are also presented. The turbulence is described by the Baldwin-Lomax algebraic turbulence model. The present L-U scheme yields stable numerical results with the use of much smaller artificial dissipations than those used in the previous steady flow solver for steady and unsteady channel flows. The capability to solve time dependent flows is shown by solving very weakly excited and strongly excited, forced oscillatory, channel flows.

  10. Fabrication, optical and scintillation properties of (Lu0.75,Y0.25)AG:Pr ceramic scintillators

    NASA Astrophysics Data System (ADS)

    Hu, Chen; Feng, Xiqi; Li, Jiang; Ge, Lin; Zhang, Yan; Kou, Huamin; Xu, Jiayue; Pan, Yubai

    2017-07-01

    Y3+ admixing Lu3Al5O12:Pr ceramics are fabricated successfully by the solid state reaction method and further optimized by an air-annealing process. Optical absorption, photoluminescence spectra and scintillation properties such as radioluminescence, and light output are measured and compared with those of the Y3+ free LuAG:Pr ceramics. Positive effect of Y3+ codopant consists mainly in the significant increase of scintillation light output, as well as the decrease of relative intensity of slow component. With 0.15% Pr3+ codoping, the obtained LuYAG:Pr ceramic displays a light output of 28500 ph/MeV at 3 μs shaping time, higher than that of the LuAG:Pr ceramic scintillators ever report. The effect of Y3+ admixture is further explained by vacuum ultraviolet and electron spin resonance experiment.

  11. The Importance of Complete Sample Dissolution and Spike-Sample Equilibration on Lu-Hf Isotope Studies

    NASA Astrophysics Data System (ADS)

    Mahlen, N. J.; Beard, B. L.; Johnson, C. M.; Lapen, T. J.

    2005-12-01

    Lu-Hf geochronology has gained attention due to its potential for precisely determining the age of garnet growth in a wide variety of rocks. A unique aspect of Lu-Hf analysis, however, is the disparate chemical behavior of Hf and Lu. For example, Hf is soluble in HF and Lu is soluble in HCl, which can create problems for spike-sample equilibration during dissolution as discussed by Unruh et al. 1984 JGR 89:B459 and later by Beard et al. 1998 GCA 62:525. Although partial dissolution may appear as an attractive means to preferentially dissolve garnet relative to refractory inclusions such as rutile and zircon, our investigations have shown that incomplete spike-sample equilibration may occur in such approaches. This leads to erroneous Lu and Hf contents that can adversely affect Lu-Hf isochron ages and calculated initial Hf isotope compositions. Dissolution of whole-rock powders using hot plates (low-pressure) or short-term microwave dissolution may produce inaccurate Lu-Hf isotope and concentration results, whereas high-temperature and -pressure dissolution in traditional Teflon steel-jacketed (Parr) bombs produces precise and accurate results. The greatest disparity in Lu-Hf isotope and concentration systematics of whole-rock powders among dissolution methods occurs for zircon- and garnet-bearing samples. In contrast, Sm-Nd isotope results are not affected by these different dissolution methods. Lu-Hf isochrons involving garnet may be affected by the dissolution method in a manner similar to that observed for whole-rock powders. Incomplete dissolution of garnet generally increases the measured Lu/Hf ratios, potentially increasing the precision of the isochron. In a number of lithologies, however, including garnet-bearing eclogites and amphibolites, significant errors may be introduced in the Lu-Hf age using hot plates (low-pressure) or short-term microwave dissolution, as compared to those obtained using high-temperature and -pressure dissolution bombs. These

  12. Internal radiotherapy and dosimetric study for 111In/ 177Lu-pegylated liposomes conjugates in tumor-bearing mice

    NASA Astrophysics Data System (ADS)

    Wang, Hsin-Ell; Yu, Hung-Man; Lu, Yi-Ching; Heish, Ning-Ning; Tseng, Yun-Long; Huang, Kuang-Liang; Chuang, Kuo-Tang; Chen, Chin-Hsiung; Hwang, Jeng-Jong; Lin, Wuu-Jyh; Wang, Shyh-Jen; Ting, Gann; Whang-Peng, Jacqueline; Deng, Win-Ping

    2006-12-01

    In vivo characterization and dosimetric analysis has been performed to evaluate the potential of pegylated liposomes as carriers of radionuclides in tumor internal radiotherapy. MethodsThe DTPA/PEG-liposomes were synthesized with a medium size of 110 nm, conjugated with 111In/ 177Lu-(oxine) 3 to afford 111In/ 177Lu-liposome. The stability of 111In/ 177Lu-liposome in serum was investigated. The biodistribution, scintigraphic imaging and pharmacokinetics of 111In/ 177Lu-liposomes after intravenous(i.v.) injection into C-26 tumor-bearing BALB/cByJ mice were studied. Radiation dose was estimated by MIRD-III program. ResultsThe incorporation efficiency of 111In/ 177Lu into liposomes was 95%. After incubation at 37 °C for 72 h in serum, more than 83% of radioactivity was still retained in the intact 111In/ 177Lu-liposomes. The biodistribution of 111In-liposomes showed that the radioactivity in the blood decreased from 23.14±8.16%ID/g at 1 h to 0.02±0.00%ID/g at 72 h post-injection (p.i.), while reaching its maximum accumulation in tumors at 48 h p.i., with half-life in blood of 10.2 h. The results were supported by that of 177Lu-liposomes. Scintigraphic imaging with 111In-liposomes showed unambiguous tumor images at 48 h p.i. Dose estimation showed that the absorbed dose in tumor from 177Lu-liposomes was 5.74×10 -5 Gy/MBq. ConclusionsThis study provides an in vivo characterization and dosimetric evaluation for the use of liposome systems as carriers in targeted radionuclide therapy. The results suggest that adequate tumor targeting as well as dose delivered to tumors could be achieved by the use of radionuclide targeted liposomes.

  13. Lu AA21004, a multimodal psychotropic agent, in the prevention of relapse in adult patients with generalized anxiety disorder.

    PubMed

    Baldwin, David S; Loft, Henrik; Florea, Ioana

    2012-07-01

    The purpose of this study was to investigate the long-term maintenance of the efficacy of Lu AA21004 5 or 10 mg/day in the prevention of relapse in patients with generalized anxiety disorder (GAD). Patients (n = 687) with a primary diagnosis of GAD (DSM-IV criteria) and a baseline Hamilton Anxiety (HAM-A) total score of at least 20 underwent a 20-week, open-label Lu AA21004 treatment. In all, 459 patients responded and were randomized to 24-56 weeks of a double-blind treatment with Lu AA21004 (n = 229) or placebo (n = 230). The predefined primary efficacy endpoint was time to relapse (HAM-A total score ≥ 15) using a Cox model; the key secondary efficacy endpoint under multiplicity control was time to relapse for patients responding to treatment for at least 12 weeks. The primary analysis showed a statistically significant effect of Lu AA21004 relative to the placebo on the time to relapse of GAD, with a hazard ratio of 2.71 (P < 0.001). There was a statistically significant effect of Lu AA21004 in the stable responders (hazard ratio = 3.06, P < 0.001). Lu AA21004 was well tolerated, with withdrawal rates due to adverse events of 9% (open-label) and 3% (placebo) and 4% (Lu AA21004) in the double-blind period. In this study, Lu AA21004 5 or 10 mg/day was efficacious in preventing relapse and was well tolerated in the maintenance treatment of GAD.

  14. Somatostatin-based radiopeptide therapy with [177Lu-DOTA]-TOC versus [90Y-DOTA]-TOC in neuroendocrine tumours.

    PubMed

    Romer, A; Seiler, D; Marincek, N; Brunner, P; Koller, M T; Ng, Q K T; Maecke, H R; Müller-Brand, J; Rochlitz, C; Briel, M; Schindler, C; Walter, M A

    2014-02-01

    Somatostatin-based radiopeptide treatment is generally performed using the β-emitting radionuclides (90)Y or (177)Lu. The present study aimed at comparing benefits and harms of both therapeutic approaches. In a comparative cohort study, patients with advanced neuroendocrine tumours underwent repeated cycles of [(90)Y-DOTA]-TOC or [(177)Lu-DOTA]-TOC until progression of disease or permanent adverse events. Multivariable Cox regression and competing risks regression were employed to examine predictors of survival and adverse events for both treatment groups. Overall, 910 patients underwent 1,804 cycles of [(90)Y-DOTA]-TOC and 141 patients underwent 259 cycles of [(177)Lu-DOTA]-TOC. The median survival after [(177)Lu-DOTA]-TOC and after [(90)Y-DOTA]-TOC was comparable (45.5 months versus 35.9 months, hazard ratio 0.91, 95% confidence interval 0.63-1.30, p = 0.49). Subgroup analyses revealed a significantly longer survival for [(177)Lu-DOTA]-TOC over [(90)Y-DOTA]-TOC in patients with low tumour uptake, solitary lesions and extra-hepatic lesions. The rate of severe transient haematotoxicities was lower after [(177)Lu-DOTA]-TOC treatment (1.4 vs 10.1%, p = 0.001), while the rate of severe permanent renal toxicities was similar in both treatment groups (9.2 vs 7.8%, p = 0.32). The present results revealed no difference in median overall survival after [(177)Lu-DOTA]-TOC and [(90)Y-DOTA]-TOC. Furthermore, [(177)Lu-DOTA]-TOC was less haematotoxic than [(90)Y-DOTA]-TOC.

  15. SuperLU{_}DIST: A scalable distributed-memory sparse direct solver for unsymmetric linear systems

    SciTech Connect

    Li, Xiaoye S.; Demmel, James W.

    2002-03-27

    In this paper, we present the main algorithmic features in the software package SuperLU{_}DIST, a distributed-memory sparse direct solver for large sets of linear equations. We give in detail our parallelization strategies, with focus on scalability issues, and demonstrate the parallel performance and scalability on current machines. The solver is based on sparse Gaussian elimination, with an innovative static pivoting strategy proposed earlier by the authors. The main advantage of static pivoting over classical partial pivoting is that it permits a priori determination of data structures and communication pattern for sparse Gaussian elimination, which makes it more scalable on distributed memory machines. Based on this a priori knowledge, we designed highly parallel and scalable algorithms for both LU decomposition and triangular solve and we show that they are suitable for large-scale distributed memory machines.

  16. Ferromagnetism strengthening in the Lu 2Fe 17- xMn x system

    NASA Astrophysics Data System (ADS)

    Kuchin, A. G.; Iwasieczko, W.; Drulis, H.; Khrabrov, V. I.

    2008-06-01

    The compounds Lu 2Fe 17- xMn x, in which x=0-2, with the Th 2Ni 17-type crystal structure were synthesized. Their structural and magnetic properties are presented. The Lu 2Fe 17- xMn x compounds with x=0-0.5 are ferromagnets at low temperatures and antiferromagnets at high temperatures. Their temperature of "ferromagnet-antiferromagnet" phase transition surprisingly increases very fast from 135 to 253 K with a growing content of Mn, whereas Néel temperature stays practically unchanged (˜278 K) and is close to Curie temperature TC=287 K for the compound with x=0.7. The compounds from the range x=0.7-2 are ferromagnets only with a near constant TC(x) value.

  17. Laser cooling of Yb³⁺-doped LuLiF₄ crystal.

    PubMed

    Zhong, Biao; Yin, Jigang; Jia, Youhua; Chen, Lin; Hang, Yin; Yin, Jianping

    2014-05-01

    In order to meet the demands for applications of optical refrigerators in the fields of spaceflight, aviation, space science, and detection, a 2 wt. % Yb3+-doped LuLiF4 crystal, as a new laser cooling material, was prepared and demonstrated by using a 178 mW diode laser centered at 1015 nm and a resonant extra-cavity scheme with an enhancement factor of 12.8. Cooling efficiency of 1.27% and a temperature drop of 14.3 K/W are obtained with 79% of the incident laser power being absorbed. Based on our results, a sample with background absorption of α=4.2×10(-4)  cm(-1) can be potentially cooled down to ∼145 K. Our investigation shows that Yb3+-doped LuLiF4 crystal is potentially a promising candidate for solid-state refrigeration.

  18. High-energy, ceramic-disk Yb:LuAG laser amplifier.

    PubMed

    Siebold, M; Loeser, M; Roeser, F; Seltmann, M; Harzendorf, G; Tsybin, I; Linke, S; Banerjee, S; Mason, P D; Phillips, P J; Ertel, K; Collier, J C; Schramm, U

    2012-09-24

    We report the first short-pulse amplification results to several hundred millijoule energies in ceramic Yb:LuAG. We have demonstrated ns-pulse output from a diode-pumped Yb:LuAG amplifier at a maximum energy of 580 mJ and a peak optical-to-optical efficiency of 28% at 550 mJ. In cavity dumped operation of a nanosecond oscillator we obtained 1 mJ at up to 100 Hz repetition rate. A gain bandwidth of 5.4 nm was achieved at room temperature by measuring the small-signal single-pass gain. Furthermore, we compared our results with Yb:YAG within the same amplifier system.

  19. High-power diode-end-pumped Tm:LiLuF4 slab lasers.

    PubMed

    Cheng, Xiaojin; Zhang, Shuaiyi; Xu, Jianqui; Peng, Haiyan; Hang, Yin

    2009-08-17

    Diode-end-pumped continuous-wave and acousto-optics Q-switched Tm:LiLuF(4) slab lasers were demonstrated. The a-cut Tm:LiLuF(4) slab with doping concentrations of 2 at.% was pumped by fast-axis collimated laser diodes at room temperature. The maximum continuous-wave output power of 10.4 W was obtained while the absorbed pump power was 31.6 W and the cavity length was 30 mm. For Q-switched operation, we got the maximum pulse energy of 8 mJ with pulse width of 315.2 ns at 1 KHz pulse repetition frequency. (c) 2009 Optical Society of America

  20. High pressure Raman scattering study on the phase stability of LuVO{sub 4}

    SciTech Connect

    Rao, Rekha; Garg, Alka B.; Sakuntala, T.; Achary, S.N.; Tyagi, A.K.

    2009-07-15

    High pressure Raman spectroscopic investigations have been carried out on rare earth orthovanadate LuVO{sub 4} upto 26 GPa. Changes in the Raman spectrum around 8 GPa across the reported zircon to scheelite transition are investigated in detail and compared with those observed in other vanadates. Co-existence of the zircon and scheelite phases is observed over a pressure range of about 8-13 GPa. The zircon to scheelite transition is irreversible upon pressure release. Subtle changes are observed in the Raman spectrum above 16 GPa which could be related to scheelite reversible fergusonite transition. Pressure dependencies of the Raman active modes in the zircon and the scheelite phases are reported. - Graphical abstract: Study of scheelite-fergusonite transition in RVO{sub 4} by Raman spectroscopy is rare. Here we report Raman spectroscopic investigations of LuVO{sub 4} at high pressure to obtain insight into nature of post-scheelite phases.

  1. Spectroscopy and laser performance of Nd:Lu_2O_3 crystal

    NASA Astrophysics Data System (ADS)

    Hao, Liangzhen; Wu, Kui; Cong, Hengjiang; Yu, Haohai; Zhang, Huaijin; Wang, Zhengping; Wang, Jiyang

    2011-08-01

    The spectra of Nd3+:Lu2O3 crystal have been examined at room temperature. Judd-Ofelt theory was applied to calculate the spectral parameters of the crystal. With a laser diode as pump source, a continuous-wave laser output power of 2.81 W is achieved, which is the highest value ever reported in this crystals to our knowledge, and its wavelength is also found to be dual-wavelength. Because of the emission cross-section at 1076 nm and 1080 nm are almost identical, laser oscillation for such two wavelengths can be obtained simultaneously. All the properties show that Nd:Lu2O3 is an excellent crystal for laser applications.

  2. An implict LU scheme for the Euler equations applied to arbitrary cascades. [new method of factoring

    NASA Technical Reports Server (NTRS)

    Buratynski, E. K.; Caughey, D. A.

    1984-01-01

    An implicit scheme for solving the Euler equations is derived and demonstrated. The alternating-direction implicit (ADI) technique is modified, using two implicit-operator factors corresponding to lower-block-diagonal (L) or upper-block-diagonal (U) algebraic systems which can be easily inverted. The resulting LU scheme is implemented in finite-volume mode and applied to 2D subsonic and transonic cascade flows with differing degrees of geometric complexity. The results are presented graphically and found to be in good agreement with those of other numerical and analytical approaches. The LU method is also 2.0-3.4 times faster than ADI, suggesting its value in calculating 3D problems.

  3. Hexagonal frustrated RMnO3 manganites (R = Y, Lu) under high pressure

    NASA Astrophysics Data System (ADS)

    Kozlenko, D. P.; Kichanov, S. E.; Lee, S.; Park, J.-G.; Glazkov, V. P.; Savenko, B. N.

    2007-05-01

    The crystalline and magnetic structures of YMnO3 and LuMnO3 hexagonal manganites under pressures of 0 6 GPa and in the temperature range 10 295 K have been investigated by neutron diffraction. Application of pressure leads to a significant decrease in the ordered magnetic moment of Mn ions (at T = 10 K) from 3.27 (0 GPa) to 1.52 μB (5 GPa) for YMnO3 and from 2.48 (0 GPa) to 1.98 μB (6 GPa) for LuMnO3. Under high pressures, spin reorientation of Mn magnetic moments and a change in the symmetry of the antiferromagnetic structure are observed in YMnO3. The relationship between the triangular lattice distortion parameter and the symmetry of the triangular antiferromagnetic state of RMnO3 hexagonal manganites is discussed.

  4. Charge gap and charge-phonon coupling in LuFe2O4

    NASA Astrophysics Data System (ADS)

    Glamazda, A.; Choi, K.-Y.; Lemmens, P.; Wulferding, D.; Park, S.; Cheong, S.-W.

    2013-04-01

    Lattice vibrations as well as electronic excitations are used to investigate LuFe2O4, which is intensively discussed in the context of electronic multiferroics. All phonon modes and an electronic continuum show drastic changes through a series of magnetic, structural, and charge ordering temperatures. In particular, the 634 cm-1 Ag mode, corresponding to the relative out-of-plane motion of a combined LuO and Fe2O3 layer, is very susceptible to the charge ordering, indicative of antipolar ordering of the Fe2O3 layer. With decreasing temperature below TCO=320 K, the electronic continuum is gradually suppressed while opening a charge gap of 790 cm-1. Its temperature dependence suggests that charge ordering is not totally frozen-in even at 5 K, signaling the importance of local charge fluctuations due to concerted charge and spin frustration.

  5. Jahn-Teller versus quantum effects in the spin-orbital material LuVO3

    DOE PAGES

    Skoulatos, M.; Toth, S.; Roessli, B.; ...

    2015-04-13

    In this article, we report on combined neutron and resonant x-ray scattering results, identifying the nature of the spin-orbital ground state and magnetic excitations in LuVO3 as driven by the orbital parameter. In particular, we distinguish between models based on orbital-Peierls dimerization, taken as a signature of quantum effects in orbitals, and Jahn-Teller distortions, in favor of the latter. In order to solve this long-standing puzzle, polarized neutron beams were employed as a prerequisite in order to solve details of the magnetic structure, which allowed quantitative intensity analysis of extended magnetic-excitation data sets. The results of this detailed study enabledmore » us to draw definite conclusions about the classical versus quantum behavior of orbitals in this system and to discard the previous claims about quantum effects dominating the orbital physics of LuVO3 and similar systems.« less

  6. Growth and characterization of Ce-doped YAG and LuAG fibers

    NASA Astrophysics Data System (ADS)

    Djebli, A.; Boudjada, F.; Pauwels, K.; Kononets, V.; Patton, G.; Benaglia, A.; Lucchini, M.; Moretti, F.; Sidletskiy, O.; Dujardin, C.; Lecoq, P.; Auffray, E.; Lebbou, K.

    2017-03-01

    Undoped and Ce-doped Lu3Al5O12 (LuAG) and Y3Al5O12 (YAG) single crystal fibers were grown by the micro-pulling down technique (μ-PD) with a purpose to fit the design of new dual-readout calorimeter planned to operate in future experiences of high energy physics. Fibers up to 20 cm in length and 1 mm in diameter were grown along [111] direction. Based on the measurements of the attenuation length along the fibers, the growth conditions to improve the fibers quality were selected. Our results showed that the grown fibers have the capability to be used for future detectors.

  7. Transculturation of Madness: The Double Origin of Lu Xun's "Diary of a Madman".

    PubMed

    Ma, Xiaolu

    2015-01-01

    Over the years scholars have examined the allegorical features of the depiction of madness in Lu Xun's "Diary of a Madman," yet to date little research has taken into consideration the intercultural angle embedded in the narrative's intersection of three cultures, namely Russian, Japanese and Chinese. This paper traces the European-Japanese-Sino route of modern neologisms of madness to explore the introduction of such neologisms into the modern Chinese language and how it corresponds with changing patterns of knowledge and power. I use my study of transculturation on the macro scale to frame a reexamination of the lexicon in "Diary of a Madman." I focus especially on kuangren and pohaikuang, the two key words employed by Lu Xun, to see how they contribute to the ambiguity in his attitude towards the power struggle between the East and the West, the old and the new.

  8. Magnetic Hyperfine Fields in Lu_2V_2O_7: A Model Approach

    NASA Astrophysics Data System (ADS)

    Agzamova, Polina; Nikiforov, Anatoliy; Nazipov, Dmitriy

    2016-12-01

    We report a theoretical approach to the investigation of the magnetic hyperfine interaction on the ^{51}V nucleus in Lu_2V_2O_7 with the view of understanding the orbital ordering pattern in this compound. First, we have evaluated the vanadium 3d^1-level splitting (Δ ) under the crystal field with the D _{3d}-symmetry using the point charges approximation. Second, we have calculated the exchange interaction constant ( J) using the ab initio approach. It is shown that the crystal field energy is much stronger than the exchange interaction one and hence the orbital liquid state cannot occur in Lu_2V_2O_7. Finally we have analyzed the magnetic hyperfine field affecting the vanadium nucleus leaning upon these results.

  9. First-principles study of electronic and elastic properties of LuAl{sub 3}

    SciTech Connect

    Shukla, Pushplata Shrivastava, Deepika; Sanyal, Sankar P.

    2016-05-06

    A systematic theoretical study of electronic structure of rare earth intermetallic LuAl{sub 3} has been carried out using full potential linearized augmented plane wave (FP-LAPW) method based on density functional theory (DFT) within the generalized gradient approximation(GGA) for exchange and correlation potential. The ground state properties such as lattice constant (a{sub o}), bulk modulus (B) and pressure derivative of bulk modulus (B′) were evaluated. LuAl{sub 3} has the cubic AuCu{sub 3} type crystal structure. The electronic properties of this compound have been analyzed quantatively from band structure and DOS. It is clear from band structure that this compound is metallic in nature. The calculated elastic constants infer that this compound is mechanically stable.

  10. Direct evidence for inelastic neutron 'acceleration' by {sup 177}Lu{sup m}

    SciTech Connect

    Roig, O.; Meot, V.; Rosse, B.; Belier, G.; Daugas, J.-M.; Morel, P.; Letourneau, A.; Menelle, A.

    2011-06-15

    The inelastic neutron acceleration cross section on the long-lived metastable state of {sup 177}Lu has been measured using a direct method. High-energy neutrons have been detected using a specially designed setup placed on a cold neutron beam extracted from the ORPHEE reactor in Saclay. The 146{+-}19 b inelastic neutron acceleration cross section in the ORPHEE cold neutron flux confirms the high cross section for this process on the {sup 177}Lu{sup m} isomer. The deviation from the 258{+-}58 b previously published obtained for a Maxwellian neutron flux at a 323 K temperature could be explained by the presence of a low energy resonance. Resonance parameters are deduced and discussed.

  11. Electronic Raman scattering and the renormalization of the electron spectrum in LuB{sub 12}

    SciTech Connect

    Ponosov, Yu. S. Streltsov, S. V.; Levchenko, A. V.; Filippov, V. B.

    2016-09-15

    The electronic Raman scattering in LuB{sub 12} single crystals of various isotope compositions is studied in the temperature range 10–650 K. The shape and the energy position of spectral maxima depend on the direction and magnitude of a probe wavevector, the temperature, and the excitation symmetry and remain unchanged when the isotope composition changes. Experimental spectra are compared with the spectra simulated on the basis of a calculated electronic structure. The experimental results are successfully described when the electron spectrum renormalization effects caused by electron–phonon coupling are taken into account. This confirms that the origin of the observed spectra in LuB{sub 12} is due to Raman scattering by electrons. A comparison of the calculated and experimental data makes it possible to determine the coupling constant (λ{sub ep} = 0.32) that gives the correct superconducting transition temperature.

  12. Kinetic control of structural and magnetic states in LuBaCo4O7.

    SciTech Connect

    Avci, S.; Chmaissem, O.; Zheng, H.; Huq, A.; Khalyavin, D.; Stephens, P.; Suchomel, M.; Manuel, P.; Mitchell, J.

    2012-01-01

    The RBaCo{sub 4}O{sub 7} (R = Ca, Y, Tb, Ho, Tm, Yb, Lu) compounds provide a novel topology for studying the competition between triangular geometry and magnetic order. Here, we report the structural and magnetic behavior of the Lu member of this series via neutron and synchrotron x-ray diffraction, magnetization, and resistivity measurements. We determined sequential phase transitions and a strong competition between a stable and a metastable low-temperature state that critically depends on controlled cooling rates and the associated heat removal kinetics. No evidence for long-range ordered magnetism was detected by neutron diffraction at any temperature. However, very slow spin dynamics are evidenced by time-dependent neutron diffraction measurements and can be explained by several competing magnetic phases with incommensurate short-range correlations coexisting in this material.

  13. Optical spectroscopy of Nd3+ in LiLuF4 single crystals

    NASA Astrophysics Data System (ADS)

    Zhao, Chengchun; Zhang, Lianhan; Hang, Yin; He, Xiaoming; Yin, Jigang; Hu, Pengchao; Chen, Guangzhu; He, Mingzhu; Huang, Huang; Zhu, Yongyuan

    2010-12-01

    The polarized absorption spectra, polarized fluorescence spectra and fluorescence decay curve of Nd3+ : LiLuF4 crystals are measured at room temperature. The peak absorption cross-sections are 6.944×10-20 cm2 and 1.664 × 10-20 cm2 at around 795 nm with full-width at half-maximum of 3.4 nm and 3.2 nm for π-polarization and σ-polarization, respectively. Based on Judd-Ofelt theory, the spectral parameters of Nd3+ in LiLuF4 crystals are investigated. The emission probabilities, branching ratio and radiative lifetime for the transitions from 4F3/2 are calculated. The radiative lifetime, fluorescence lifetime and quantum efficiency are 536 µs, 489 µs and 91%, respectively. Its spectroscopic parameters are also compared with those of some other important Nd3+-doped laser crystals.

  14. Exchange effects on the electronic excitations in the optical spectrum of LuMnO_3

    NASA Astrophysics Data System (ADS)

    Drew, H. D.; Simpson, J. R.; Sushkov, A. B.; Romero, D. B.; Quijada, M.; Ahn, J. S.; Ishibashi, H.; Hur, N.; Cheong, S. W.; Millis, A. J.

    2003-03-01

    Hexagonal LuMnO3 is a multiferroic material with ferroelectric phase transition at 900 K and it becomes an antiferromagnet with a high degree of frustration at 90 K. We have measured the optical conductivity of single crystal LuMnO3 from 1 meV to 5.5 eV in E||c and E⊥ c polarizations at temperatures between 4 and 300 K. A symmetry allowed (E⊥ c) on-site d-d transition near 1.7 eV is observed to blue shift ( ˜0.15 eV) with an inflection point at TN in the antiferromagnetic state due to Mn-Mn exchange energy effects. Photoluminescence measurements reveal a Jahn-Teller splitting in the optical excited state. This work has been supported by the NSF-MRSEC at the University of Maryland, DMR 0080008.

  15. Spin wave and spin flip in hexagonal LuMnO3 single crystal

    NASA Astrophysics Data System (ADS)

    Chen, Xiang-Bai; Guo, Peng-Cheng; Huyen, Nguyen Thi; Kim, Seung; Yang, In-Sang; Wang, Xueyun; Cheong, Sang-Wook

    2017-03-01

    Manipulation and control of spin wave and spin flip are crucial for future developments of magnonic and spintronic devices. We present that the spin wave in hexagonal LuMnO3 single crystal can be selectively excited with laser polarization perpendicular to the c-axis of hexagonal LuMnO3 and photon energy ˜1.8 eV. The selective excitation of spin wave also suggests that the spin flip can be selectively controlled in hexagonal manganites. In addition, a microscopic model of the spin wave generation correlated with the four-spin-flip in hexagonal manganites is suggested to account for the line-shape of the observed spin wave.

  16. Peculiarities of thermoelectric half-Heusler phase formation in Gd-Ni-Sb and Lu-Ni-Sb ternary systems

    NASA Astrophysics Data System (ADS)

    Romaka, V. V.; Romaka, L.; Horyn, A.; Rogl, P.; Stadnyk, Yu; Melnychenko, N.; Orlovskyy, M.; Krayovskyy, V.

    2016-07-01

    The phase equilibria in the Gd-Ni-Sb and Lu-Ni-Sb ternary systems were studied at 873 K by X-ray and metallographic analyses in the whole concentration range. The interaction of the elements in the Gd-Ni-Sb system results the formation of five ternary compounds at investigated temperature: Gd5Ni2Sb (Mo5SiB2-type), Gd5NiSb2 (Yb5Sb3-type), GdNiSb (MgAgAs-type), Gd3Ni6Sb5 (Y3Ni6Sb5-type), and GdNi0.72Sb2 (HfCuSi2-type). At investigated temperature the Lu-Ni-Sb system is characterized by formation of the LuNiSb (MgAgAs-type), Lu5Ni2Sb (Mo5SiB2-type), and Lu5Ni0.56Sb2.44 (Yb5Sb3-type) compounds. The disordering in the crystal structure of half-Heusler GdNiSb and LuNiSb was revealed by EPMA and studied by means of Rietveld refinement and DFT modeling. The performed electronic structure calculations are in good agreement with electrical transport property studies.

  17. Effect of Li+ ions co-doping on luminescence, scintillation properties and defects characteristics of LuAG:Ce ceramics

    NASA Astrophysics Data System (ADS)

    Liu, Shuping; Feng, Xiqi; Mares, Jiri A.; Babin, Vladimir; Hu, Chen; Kou, Huamin; D'Ambrosio, Carmelo; Li, Jiang; Pan, Yubai; Nikl, Martin

    2017-02-01

    Monovalent Li+ codoped Lu3Al5O12:Ce (LuAG:Ce) optical ceramics were fabricated by solid state reaction method and further optimized by an air-annealing process. Optical absorption, radioluminescence spectra and scintillation properties such as light yield, scintillation decay times and afterglow were measured and compared with those of the Li+ free LuAG:Ce ceramic and the commercial LuAG:Ce single crystal samples. Positive effect of Li+ codopant consists mainly in the significant increase of scintillation light yield, acceleration of scintillation decay as well as the decrease of afterglow intensity. With 0.3% Li codoping, the obtained LuAG:Ce,Li ceramic displays a light yield of ∼29200 ph/MeV at 10 μs shaping time, higher than that of the LuAG:Ce single crystal and optical ceramic scintillators ever reported. The partial conversion of the stable Ce3+ to Ce4+ centers and the shallow and deep traps effect suppression by the Li+ codoping are discussed.

  18. Spin-lattice coupling and frustrated magnetism in Fe-doped hexagonal LuMnO3

    NASA Astrophysics Data System (ADS)

    Nair, Harikrishnan S.; Fu, Zhendong; Kumar, C. M. N.; Pomjakushin, V. Y.; Xiao, Yinguo; Chatterji, Tapan; Strydom, André M.

    2015-05-01

    Strong spin-lattice coupling and prominent frustration effects observed in the 50% Fe-doped frustrated hexagonal (h)\\text{LuMnO}3 are reported. A Néel transition at T{N}≈112 \\text{K} and a possible spin re-orientation transition at T{SR}≈55 \\text{K} are observed in the magnetization data. From neutron powder diffraction data, the nuclear structure at and below 300 K was refined in polar P63cm space group. While the magnetic structure of LuMnO3 belongs to the Γ4 (P6'_3c'm) representation, that of LuFe0.5Mn0.5O3 belongs to Γ1 (P6_3cm) which is supported by the strong intensity for the (100) reflection and also judging by the presence of spin-lattice coupling. The refined atomic positions for Lu and Mn/Fe indicate significant atomic displacements at T{N} and T{SR} which confirms strong spin-lattice coupling. Our results complement the discovery of room temperature multiferroicity in thin films of h\\text{LuFeO}3 and would give impetus to study LuFe1-x Mn x O3 systems as potential multiferroics where electric polarization is linked to giant atomic displacements.

  19. Electric quadrupole moments and strong interaction effects in pionic atoms of /sup 165/Ho, /sup 175/Lu, /sup 176/Lu, /sup 179/Hf and /sup 181/Ta

    SciTech Connect

    Olaniyi, B.H.

    1980-01-01

    The effective quadrupole moments Q/sub eff/ of the nuclei of /sup 165/Ho, /sup 175/Lu, /sup 176/Lu, /sup 179/Hf and /sup 181/Ta were accurately measured by detecting the pionic atom 5g-4f x-rays of the elements. The spectroscopic quadrupole moments, Q/sub spec/, were obtained by correcting Q/sub eff/ for nuclear finite size effect, distortion of the pion wave function by the pion-nucleus strong interaction, and contribution to the energy level splittings by the strong interaction. The intrinsic quadrupole moments, Q/sub 0/, were obtained by projecting Q/sub spec/ into the frame of reference fixed on the nucleus. The shift, epsilon/sub 0/, and broadening, GAMMA/sub 0/, of the 4f energy level for all the elements were also measured. Theoretical values of epsilon/sub 0/ and GAMMA/sub 0/ were calculated and compared to the experimental values. The measured values of Q/sub 0/ were compared with existing results in muonic and pionic atoms. The measured values of epsilon/sub 0/ and GAMMA/sub 0/ were also compared with existing values.

  20. Quantitative (177)Lu SPECT imaging using advanced correction algorithms in non-reference geometry.

    PubMed

    D'Arienzo, M; Cozzella, M L; Fazio, A; De Felice, P; Iaccarino, G; D'Andrea, M; Ungania, S; Cazzato, M; Schmidt, K; Kimiaei, S; Strigari, L

    2016-12-01

    Peptide receptor therapy with (177)Lu-labelled somatostatin analogues is a promising tool in the management of patients with inoperable or metastasized neuroendocrine tumours. The aim of this work was to perform accurate activity quantification of (177)Lu in complex anthropomorphic geometry using advanced correction algorithms. Acquisitions were performed on the higher (177)Lu photopeak (208keV) using a Philips IRIX gamma camera provided with medium-energy collimators. System calibration was performed using a 16mL Jaszczak sphere surrounded by non-radioactive water. Attenuation correction was performed using μ-maps derived from CT data, while scatter and septal penetration corrections were performed using the transmission-dependent convolution-subtraction method. SPECT acquisitions were finally corrected for dead time and partial volume effects. Image analysis was performed using the commercial QSPECT software. The quantitative SPECT approach was validated on an anthropomorphic phantom provided with a home-made insert simulating a hepatic lesion. Quantitative accuracy was studied using three tumour-to-background activity concentration ratios (6:1, 9:1, 14:1). For all acquisitions, the recovered total activity was within 12% of the calibrated activity both in the background region and in the tumour. Using a 6:1 tumour-to-background ratio the recovered total activity was within 2% in the tumour and within 5% in the background. Partial volume effects, if not properly accounted for, can lead to significant activity underestimations in clinical conditions. In conclusion, accurate activity quantification of (177)Lu can be obtained if activity measurements are performed with equipment traceable to primary standards, advanced correction algorithms are used and acquisitions are performed at the 208keV photopeak using medium-energy collimators. Copyright © 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  1. Competing Ferri- and Antiferromagnetic Phases in Geometrically Frustrated LuFe2O4

    SciTech Connect

    De Groot, J.; Marty, Karol J; Lumsden, Mark D; Christianson, Andrew D; Nagler, Stephen E; Adiga, Shilpa; Borghols, Wouter; Schmalzl, Karin; Yamani, Z.; Bland, S. R.; de Souza, R.; Staub, U.; Schweika, Werner; Su, Y.; Angst, Manuel

    2012-01-01

    We present a detailed study of magnetism in LuFe2O4, combining magnetization measurements with neutron and soft x-ray diffraction. The magnetic phase diagram in the vicinity of TN involves a metamagnetic transition separating an antiferro- and a ferrimagnetic phase. For both phases the spin structure is refined by neutron diffraction. Observed diffuse magnetic scattering far above TN is explained in terms of near degeneracy of the magnetic phases.

  2. Morphology evolution and pure red upconversion mechanism of β-NaLuF4 crystals.

    PubMed

    Lin, Hao; Xu, Dekang; Li, Anming; Teng, Dongdong; Yang, Shenghong; Zhang, Yueli

    2016-06-16

    A series of β-NaLuF4 crystals were synthesized via a hydrothermal method. Hexagonal phase microdisks, microprisms, and microtubes were achieved by simply changing the amount of citric acid in the initial reaction solution. Pure red upconversion (UC) luminescence can be observed in β-NaLuF4:Yb(3+), Tm(3+), Er(3+) and Li(+) doped β-NaLuF4:20% Yb(3+), 1% Tm(3+), 20% Er(3+). Based on the rate equations, we report the theoretical model about the pure red UC mechanism in Yb(3+)/Tm(3+)/Er(3+) doped system. It is proposed that the pure red UC luminescence is mainly ascribed to the energy transfer UC from Tm(3+):(3)F4 → (3)H6 to Er(3+):(4)I11/2 → (4)F9/2 and the cross-relaxation (CR) effect [Er(3+):(4)S3/2 + (4)I15/2 → (4)I9/2 + (4)I13/2] rather than the long-accepted mechanism [CR process among Er(3+):(4)F7/2 + (4)I11/2 → (4)F9/2 + (4)F9/2]. In addition, compared to the Li(+)-free counterpart, the pure red UC luminescence in β-NaLuF4:20% Yb(3+), 1% Tm(3+), 20% Er(3+) with 15 mol% Li(+) doping is enhanced by 13.7 times. This study provides a general and effective approach to obtain intense pure red UC luminescence, which can be applied to other synthetic strategies.

  3. Neutron capture measurement on {sup 173}Lu at LANSCE with DANCE detector

    SciTech Connect

    Theroine, C.; Ebran, A.; Meot, V.; Roig, O.; Bond, E. M.; Bredeweg, T. A.; Couture, A.; Haight, R. C.; Jandel, M.; Nortier, F. M.; O'Donnell, J. M.; Rundberg, R. S.; Taylor, W. A.; Ullmann, J. L.; Viera, D. J.; Wilhelmy, J. B.; Wouters, J. M.

    2013-06-10

    The (n,{gamma}) cross section on the unstable {sup 173}Lu(t{sub 1/2} = 1.37y) has been measured from thermal energy up to 200 eV at Los Alamos Neutron Science Center (LANSCE) with The Detector for Advanced Neutron Capture Experiements (DANCE). The main aim of this study is to validate and optimize reaction models for unstable nucleus. A preliminary capture yield will be presented in this paper.

  4. Magnetic Properties of RB66 (R = Gd, Tb, Ho, Er, and Lu)

    SciTech Connect

    Kim, Hyunsoo; Budko, Serguei; ATanatar, Makariy; Avdashchenko, D.V.; Matovnikov, A.V.; Mitroshenkov, N.V.; Novikov, V.V.; Prozorov, Ruslan

    2012-05-17

    We report magnetic susceptibility measurements of RB66 (R = Gd, Tb, Ho, Er, and Lu) boron-rich rare earth containing borides down to 50 mK. The data suggest a spin glass low temperature state for RB66 (R = Gd, Tb, Ho, and Er) with the freezing temperatures below 1 K. The magnetic properties appear to be influenced by the anisotropy of the magnetic moments, probably via the crystalline electric field effects.

  5. The Lu-Hf isotope system in the Acasta gneiss complex (NWT, Canada)

    NASA Astrophysics Data System (ADS)

    Guitreau, Martin; Blichert-Toft, Janne; Mojzsis, Stephen J.; Roth, Antoine S. G.; Bourdon, Bernard; Bleeker, Wouter

    2013-04-01

    The Acasta gneiss complex (AGC) is an outcrop of poly-phase Hadean/Eoarchean rocks that records a multi-stage history. We explore the complexities encountered in such an old crustal remnant at the mineral- to outcrop scale and discuss the preservation and disturbance of the Lu-Hf isotope system in these rocks. Twenty-one new Lu-Hf isotope whole rock measurements are used in combination with previous data to show that some samples have been disturbed by metamorphic garnet growth and/or migmatization/mineral segregation while others clearly preserve their Lu-Hf isotope systematics. Two main Archean magmatic events to be identified at around 3600 and 3960 Ma and an almost purely metamorphic event at about 3750 Ma. Least-contaminated gneisses indicate a Lu-Hf isochron age range of 3929 ± 84 to 3945 ± 91 Ma for the oldest rocks that range from mafic to felsic. This age discrepancy relative to 3960 Ma is likely due to crust assimilation. This process is significant in both magmatic groups in the AGC as also observed by previous authors. However, our study demonstrates that crustal contamination is widespread but not ubiquitous and, according to assimilation calculations, the least contaminated samples identified here indicate a near-CHUR Hf isotope composition for the mantle source of 3960 Ma group. Comparison between Hf isotopes in >3.9 Ga detrital zircons from North-American Archean meta-sedimentary basins and those in Acasta gneisses indicate a possible connection that would in turn imply that the AGC was volumetrically significant. Analogy with western Australian Hadean zircon bearing meta-sedimentary belts would point out to local effects in early crustal record in favor of progressive (but not continuous) crustal growth as independent crustal segments in the Hadean-Eoarchean.

  6. Yb doping concentration and temperature influence on Yb:LuAG thermal lensing

    NASA Astrophysics Data System (ADS)

    Veselský, Karel; Šulc, Jan; Jelínková, Helena; Nejezchleb, Karel; Škoda, Václav

    2016-03-01

    The aim of this study was to investigate whether refractive power of thermal lens for Yb:LuAG crystal at cryogenic temperatures depends on Yb doping concentration which has not been examined yet. The three measured Yb:LuAG laser rods samples (length of 3 mm, diameter 3 mm, AR @ 0.94 μm and 1.03 μm, doping concentration 5.4, 8.4 and 16.6 at. % Yb/Lu) were mounted in the temperature controlled copper holder of the liquid nitrogen cryostat. Samples were longitudinally pumped with fiber coupled CW laser diode at 0.930 μm with the focal point 0.4 mm in diameter. The 38 mm long semi-hemispherical laser resonator consisted of a flat pump mirror (HR @ 1.03 μm and HT 0.94 μm) and curved output coupler (r=500 mm) of reflectivity 94 % @ 1.06 μm. The refractive power of thermal lens was estimated indirectly by measuring of change in the position of focused laser beam focal point. The measurement was performed for constant absorbed power of 10 W in temperature range from 80 up to 240 K. It was observed that cryogenic cooling caused reduction of thermal lens power, which increased linearly with increasing temperature. For temperatures from 80 to 160 K refractive power was identical for all concentration. For higher temperature the refractive power of thermal lens increased with increasing Yb3+ concentration. Presented study shows that application of cryogenic temperature leads to reduction of thermal effect even for high dopant concentration in Yb:LuAG crystal. This is essential for reaching of high output power while maintaining high beam quality.

  7. First principle calculation of structure and lattice dynamics of Lu2Si2O7

    NASA Astrophysics Data System (ADS)

    Nazipov, D. V.; Nikiforov, A. E.

    2016-12-01

    Ab initio calculations of crystal structure and Raman spectra has been performed for single crystal of lutetium pyrosilicate Lu2Si2O7. The types of fundamental vibrations, their frequencies and intensities in the Raman spectrum has been obtained for two polarizations. Calculations were made in the framework of density functional theory (DFT) with hybrid functionals. The isotopic substitution was calculated for all inequivalent ions in cell. The results in a good agreement with experimental data.

  8. Morphology evolution and pure red upconversion mechanism of β-NaLuF4 crystals

    PubMed Central

    Lin, Hao; Xu, Dekang; Li, Anming; Teng, Dongdong; Yang, Shenghong; Zhang, Yueli

    2016-01-01

    A series of β-NaLuF4 crystals were synthesized via a hydrothermal method. Hexagonal phase microdisks, microprisms, and microtubes were achieved by simply changing the amount of citric acid in the initial reaction solution. Pure red upconversion (UC) luminescence can be observed in β-NaLuF4:Yb3+, Tm3+, Er3+ and Li+ doped β-NaLuF4:20% Yb3+, 1% Tm3+, 20% Er3+. Based on the rate equations, we report the theoretical model about the pure red UC mechanism in Yb3+/Tm3+/Er3+ doped system. It is proposed that the pure red UC luminescence is mainly ascribed to the energy transfer UC from Tm3+:3F4 → 3H6 to Er3+:4I11/2 → 4F9/2 and the cross-relaxation (CR) effect [Er3+:4S3/2 + 4I15/2 → 4I9/2 + 4I13/2] rather than the long-accepted mechanism [CR process among Er3+:4F7/2 + 4I11/2 → 4F9/2 + 4F9/2]. In addition, compared to the Li+-free counterpart, the pure red UC luminescence in β-NaLuF4:20% Yb3+, 1% Tm3+, 20% Er3+ with 15 mol% Li+ doping is enhanced by 13.7 times. This study provides a general and effective approach to obtain intense pure red UC luminescence, which can be applied to other synthetic strategies. PMID:27306720

  9. Ultra-fast LuI{sub 3}:Ce scintillators for hard x-ray imaging

    SciTech Connect

    Marton, Zsolt Miller, Stuart R.; Ovechkina, Elena; Singh, Bipin; Nagarkar, Vivek V.; Kenesei, Peter; Moore, Matthew D.; Woods, Russell; Almer, Jonathan D.; Miceli, Antonino

    2016-07-27

    We have developed ultra-fast cerium-coped lutetium-iodide (LuI{sub 3}:Ce) films thermally evaporated as polycrystalline, structured scintillator using hot wall epitaxy (HWE) method. The films have shown a 13 ns decay compared to the 28 ns reported for crystals. The fast speed coupled with its high density (∼5.6 g/cm{sup 3}), high effective atomic number (59.7), and the fact that it can be vapor deposited in a columnar form makes LuI{sub 3}:Ce an attractive candidate for high frame rate, high-resolution, hard X-ray imaging. In crystal form, LuI{sub 3}:Ce has demonstrated bright (>100,000 photons/MeV) green (540 nm) emission, which is well matched to commercial CCD/CMOS sensors and is critical for maintaining high signal to noise ratio in light starved applications. Here, we report on the scintillation properties of films and those for corresponding crystalline material. The vapor grown films were integrated into a high-speed CMOS imager to demonstrate high-speed radiography capability. The films were also tested at Advanced Photon Source, Argonne National Laboratory beamline 1-ID under hard X-ray irradiation. The data show a factor of four higher efficiency than the reference LuAG:Ce scintillators, high image quality, and linearity of scintillation response over a wide energy range. The films were employed to perform hard X-ray microtomography, the results of which will also be discussed.

  10. Morphology evolution and pure red upconversion mechanism of β-NaLuF4 crystals

    NASA Astrophysics Data System (ADS)

    Lin, Hao; Xu, Dekang; Li, Anming; Teng, Dongdong; Yang, Shenghong; Zhang, Yueli

    2016-06-01

    A series of β-NaLuF4 crystals were synthesized via a hydrothermal method. Hexagonal phase microdisks, microprisms, and microtubes were achieved by simply changing the amount of citric acid in the initial reaction solution. Pure red upconversion (UC) luminescence can be observed in β-NaLuF4:Yb3+, Tm3+, Er3+ and Li+ doped β-NaLuF4:20% Yb3+, 1% Tm3+, 20% Er3+. Based on the rate equations, we report the theoretical model about the pure red UC mechanism in Yb3+/Tm3+/Er3+ doped system. It is proposed that the pure red UC luminescence is mainly ascribed to the energy transfer UC from Tm3+:3F4 → 3H6 to Er3+:4I11/2 → 4F9/2 and the cross-relaxation (CR) effect [Er3+:4S3/2 + 4I15/2 → 4I9/2 + 4I13/2] rather than the long-accepted mechanism [CR process among Er3+:4F7/2 + 4I11/2 → 4F9/2 + 4F9/2]. In addition, compared to the Li+-free counterpart, the pure red UC luminescence in β-NaLuF4:20% Yb3+, 1% Tm3+, 20% Er3+ with 15 mol% Li+ doping is enhanced by 13.7 times. This study provides a general and effective approach to obtain intense pure red UC luminescence, which can be applied to other synthetic strategies.

  11. Implementation of BT, SP, LU, and FT of NAS Parallel Benchmarks in Java

    NASA Technical Reports Server (NTRS)

    Schultz, Matthew; Frumkin, Michael; Jin, Hao-Qiang; Yan, Jerry

    2000-01-01

    A number of Java features make it an attractive but a debatable choice for High Performance Computing. We have implemented benchmarks working on single structured grid BT,SP,LU and FT in Java. The performance and scalability of the Java code shows that a significant improvement in Java compiler technology and in Java thread implementation are necessary for Java to compete with Fortran in HPC applications.

  12. Heat capacity and thermal expansion of icosahedral lutetium boride LuB66

    SciTech Connect

    Novikov, V V; Avdashchenko, D V; Matovnikov, A V; Mitroshenkov, N V; Bud’ko, S L

    2014-01-07

    The experimental values of heat capacity and thermal expansion for lutetium boride LuB66 in the temperature range of 2-300 K were analysed in the Debye-Einstein approximation. It was found that the vibration of the boron sub-lattice can be considered within the Debye model with high characteristic temperatures; low-frequency vibration of weakly connected metal atoms is described by the Einstein model.

  13. Test beam results of a high granularity LuAG fibre calorimeter prototype

    NASA Astrophysics Data System (ADS)

    Benaglia, A.; Lucchini, M.; Pauwels, K.; Tully, C.; Medvedeva, T.; Heering, A.; Dujardin, C.; Kononets, V.; Lebbou, K.; Aubry, N.; Faraj, S.; Ferro, G.; Lecoq, P.; Auffray, E.

    2016-05-01

    The progresses in the micropulling-down technique allow heavy scintillating crystals to be grown directly into a fibre geometry of variable shape, length and diameter. Examples of materials that can be grown with this technique are Lutetium Aluminum Garnets (LuAG, Lu3Al5O12) and Yttrium Aluminum Garnets (YAG, Y3Al5O12). Thanks to the flexibility of this approach, combined with the high density and good radiation hardness of the materials, such a technology represents a powerful tool for the development of future calorimeters. As an important proof of concept of the application of crystal fibres in future experiments, a small calorimeter prototype was built and tested on beam. A grooved brass absorber (dimensions 26cm×7cm×16cm) was instrumented with 64 LuAG fibres, 56 of which were doped with Cerium, while the remaining 8 were undoped. Each fibre was readout individually using 8 eightfold Silicon Photomultiplier arrays, thus providing a highly granular description of the shower development inside the module as well as good tracking capabilities. The module was tested at the Fermilab Test Beam Facility using electrons and pions in the 2-16 GeV energy range. The module performance as well as fibre characterization results from this beam test are presented.

  14. Standardization and measurement of gamma-ray probability per decay of 177Lu.

    PubMed

    Dias, Mauro S; Silva, Fabrício F V; Koskinas, Marina F

    2010-01-01

    The procedure followed by the Nuclear Metrology Laboratory (LMN), at the Nuclear and Energy Research Institute (IPEN), for the primary standardization of (177)Lu is described. This radionuclide is widely used in radiopharmacy due to its convenient half-life and emitted beta ray energies. The (177)Lu solution was supplied during an international comparison sponsored by BIPM in 2009 and the primary standardization has been accomplished by the 4pibeta-gamma coincidence method using a proportional counter in 4pi geometry coupled with two NaI(Tl) scintillation counters. The beta efficiency was varied by placing Collodion and aluminum absorbers over and under the radioactive source. The (177)Lu calibrated sources were also measured in a previously calibrated HPGe spectrometer, in order to obtain the emission probability per decay for the selected gamma-ray transitions. The experimental extrapolation curves were also compared with Monte Carlo simulations by means of code ESQUEMA developed at the LMN. Copyright 2009 Elsevier Ltd. All rights reserved.

  15. A comparison of SuperLU solvers on the intel MIC architecture

    NASA Astrophysics Data System (ADS)

    Tuncel, Mehmet; Duran, Ahmet; Celebi, M. Serdar; Akaydin, Bora; Topkaya, Figen O.

    2016-10-01

    In many science and engineering applications, problems may result in solving a sparse linear system AX=B. For example, SuperLU_MCDT, a linear solver, was used for the large penta-diagonal matrices for 2D problems and hepta-diagonal matrices for 3D problems, coming from the incompressible blood flow simulation (see [1]). It is important to test the status and potential improvements of state-of-the-art solvers on new technologies. In this work, sequential, multithreaded and distributed versions of SuperLU solvers (see [2]) are examined on the Intel Xeon Phi coprocessors using offload programming model at the EURORA cluster of CINECA in Italy. We consider a portfolio of test matrices containing patterned matrices from UFMM ([3]) and randomly located matrices. This architecture can benefit from high parallelism and large vectors. We find that the sequential SuperLU benefited up to 45 % performance improvement from the offload programming depending on the sparse matrix type and the size of transferred and processed data.

  16. Enhancement of the magnetocaloric effect in the LuFeMn system

    NASA Astrophysics Data System (ADS)

    Kuchin, A. G.; Iwasieczko, W.

    2010-09-01

    Non-monotonic variation of the magnetocaloric effect (MCE) with a maximal value for the composition x=0.7 has been observed in the Lu 2Fe 17- xMn x system by means of isothermal magnetic measurements. The Lu 2Fe 17- xMn x compounds with x=0-0.5 are ferromagnets at low temperatures and antiferromagnets at high temperatures, with a near-constant Néel temperature TN˜278 K. The temperature of the "ferromagnet-antiferromagnet" phase transition, ΘT, increases rapidly with increasing content of Mn, and the compounds from the range x=0.7-2 are ferromagnets only, with the practically unchanged Curie temperature, TC(0.7)=287 K. Thus, first- and second-order magnetic transitions merge for the composition Lu 2Fe 16.3Mn 0.7, where the associated entropy change |ΔSM| is 3.6 J/kg K at 300 K in a field of 5 T. This is a way of enhancing the MCE in such multicomponent systems.

  17. Normal and superdeformed high-spin structures in {sup 161}Lu

    SciTech Connect

    Bringel, P.; Huebel, H.; Al-Khatib, A.; Buerger, A.; Nenoff, N.; Neusser-Neffgen, A.; Schoenwasser, G.; Singh, A.K.; Hagemann, G.B.; Herskind, B.; Jensen, D.R.; Sletten, G.; Bednarczyk, P.; Curien, D.; Joss, D.T.; Simpson, J.; Gangopadhyay, G.; Kroell, Th.; Lo Bianco, G.; Petrache, C.M.

    2006-05-15

    High-spin states in {sup 161}Lu were populated in the {sup 139}La({sup 28}Si, 6n) reaction and {gamma}-ray coincidences were measured with the EUROBALL spectrometer. On the basis of these data, the previously known level scheme is extended with new band structures and is partly revised. Configuration assignments are made to all bands based on comparison of experimental properties with cranked shell model calculations. A strongly populated band with parity and signature ({pi},{alpha})=(+,-1/2) is found to be yrast above spin I{approx_equal}33. This band shows characteristics resembling those of two triaxial superdeformed bands in this nucleus based on the occupation of the shape-driving i{sub 13/2} proton orbital. This structure, unique to {sup 161}Lu within the chain of even-N Lu isotopes, is discussed in terms of a quasiparticle configuration in a local triaxial minimum with a larger triaxiality and a smaller quadrupole deformation than calculated for the i{sub 13/2} proton excitation.

  18. An In-Depth Analysis of the Chung-Lu Model

    SciTech Connect

    Winlaw, M.; DeSterck, H.; Sanders, G.

    2015-10-28

    In the classic Erd}os R enyi random graph model [5] each edge is chosen with uniform probability and the degree distribution is binomial, limiting the number of graphs that can be modeled using the Erd}os R enyi framework [10]. The Chung-Lu model [1, 2, 3] is an extension of the Erd}os R enyi model that allows for more general degree distributions. The probability of each edge is no longer uniform and is a function of a user-supplied degree sequence, which by design is the expected degree sequence of the model. This property makes it an easy model to work with theoretically and since the Chung-Lu model is a special case of a random graph model with a given degree sequence, many of its properties are well known and have been studied extensively [2, 3, 13, 8, 9]. It is also an attractive null model for many real-world networks, particularly those with power-law degree distributions and it is sometimes used as a benchmark for comparison with other graph generators despite some of its limitations [12, 11]. We know for example, that the average clustering coe cient is too low relative to most real world networks. As well, measures of a nity are also too low relative to most real-world networks of interest. However, despite these limitations or perhaps because of them, the Chung-Lu model provides a basis for comparing new graph models.

  19. (177)Lu-DOTATATE treatment in neuroendocrine tumours. A preliminary study.

    PubMed

    Hervás, I; Bello, P; Falgas, M; Del Olmo, M I; Torres, I; Olivas, C; Vera, V; Oliván, P; Yepes, A M

    Therapy with radiolabelled somatostatin analogue peptides is a promising new therapy to treat neuroendocrine tumours. The aim of this preliminary study is to present our experience with (177)Lu-DOTATATE therapy, and evaluate tolerability and short-term efficacy in patients with tumours expressing somatostatin receptors. A total of 7 patients with metastatic neuroendocrine tumours were treated, each with 4 doses of (177)Lu-DOTATATE. The treatment response was evaluated in the form of biochemical response (tumour markers), imaging methods (somatostatin receptor scintigraphy, computed tomography, and magnetic resonance), and functional and quality of life responses using the Karnofsky performance status scale. Treatment toxicity was also evaluated. The results obtained were as follows: Biochemical response: 60% of patients showed tumour marker levels returning to normal, while they decreased significantly in the remaining 40%. Imaging response: 85.7% had a partial response, while 14.3% showed stable disease. All (100%) patients showed a significant improvement in quality of life, with increased Karnofsky scale scores. No patient had acute or chronic toxicity, and subacute transient haematological toxicity was observed in 42.8% of patients. Despite being a preliminary study, it was found that treatment with (177)Lu-DOTATATE is a safe treatment with few side effects, and an objective response was achieved in most patients. Copyright © 2016 Elsevier España, S.L.U. y SEMNIM. All rights reserved.

  20. Radiolabeling of monoclonal anti-CD105 with (177)Lu for potential use in radioimmunotherapy.

    PubMed

    Lee, So-Young; Hong, Young-Don; Felipe, Penelope M; Pyun, Mi-Sun; Choi, Sun-Ju

    2009-01-01

    In this study, we carried out a radioimmunoconjugation using (177)Lu with anti-CD105 (endoglin) monoclonal antibody for an angiogenesis targeting. CD105 has been shown to be a more useful marker to identify proliferating endothelium involved in tumor angiogenesis than panendothelial markers. We optimized the labeling of the anti-CD105 monoclonal antibody with (177)Lu by using cysteine derivative isothiocyanatobenzyl-DTPA (DTPA-NCS) as BFCA. Under the optimal conditions, labeling yield was greater than 99%. Immunoactivity of the radioimmunoconjugate was investigated using combinations of radioanalytical and bioanalytical techniques (ITLC-SG, Cyclone phosphorimager, SDS-PAGE and ELISA). For the biological evaluations we carried out a cell binding assay and a biodistribution study using mice bearing Calu6 lung cancer cell xenografts. The tumor-to-blood ratio was 11.16:1 24h post-injection. In conclusion, the anti-CD105 monoclonal antibody for an angiogenesis targeting was effectively radioconjugated with (177)Lu. And the biodistribution study showed a high specificity for accumulating in tumor tissues. This radioimmunoconjugate is applicable to detect angiogenesis sites in various diseases and to treat tumors.

  1. Identification of a proton-emitting isomer in {sup 151}Lu

    SciTech Connect

    Bingham, C.R.; Grzywacz, R.; Kim, S.H.; Weintraub, W.; Bingham, C.R.; Rykaczewski, K.; Toth, K.S.; Yu, C.; Gross, C.J.; Mas, J.; McConnell, J.W.; Batchelder, J.C.; Ginter, T.N.; Gross, C.J.; MacDonald, B.D.; Karny, M.; Mas, J.; Szerypo, J.; Semmes, P.B.; Zganjar, E.F.

    1999-06-01

    An isomer of {sup 151}Lu was identified by its direct proton radioactivity. It was produced by bombardment of {sup 96}Ru with 266-MeV {sup 58}Ni from the Holifield Radioactive-Ion Beam Facility, mass separated with a recoil separator and implanted in a double-sided silicon strip detector, which provided signals to correlate each proton decay with a particular implant. The proton energy and half-life of {sup 151}Lu{sup m} were measured to be 1310(10) keV and 16(1) {mu}s, respectively. The half-life of the previously known h{sub 11/2} ground state was observed to be 80(2) ms in agreement with the previously adopted value of 88(10) ms. Comparison of the half-life of {sup 151}Lu{sup m} with WKB barrier-penetration calculations leads to the conclusion that the isomer is a d{sub 3/2} proton state. A two-potential approach predicts a half-life of 5.5{sub {minus}1.1}{sup +1.4} {mu}s which yields an experimental spectroscopic factor of 0.34{sub {minus}0.08}{sup +0.12}. {copyright} {ital 1999} {ital The American Physical Society}

  2. Illustrations of neurosurgical techniques in early period of Ottoman Empire by Serefeddin Sabuncuoğlu.

    PubMed

    Turgut, M

    2007-10-01

    Serefeddin Sabuncuoğlu (A.D. 1385-1468) was the author of the first illustrated surgery atlas Cerrahiyyetü'l Haniyye (Imperial Surgery), which was written in Turkish in 1465. The purpose of this report is to present his unique contribution to modern neurological surgery. Cerrahiyyetü'l Haniyye consists of 412 pages in three chapters, in which there are a total of 191 sections dealing with a variety of surgical specialties, including neurosurgery. In each section of the book, a sentence written in rhyme and meter gives the diagnosis, classification and surgical technique in detail. Serefeddin Sabuncuoğlu describes medical and surgical management of neurological diseases such as spinal trauma, epilepsy, migraine, facial palsy, hemiplegia, low back pain, cranial fracture, hydrocephalus and abscesses of the head in his textbook. Serefeddin Sabuncuoğlu was a great surgeon in Turkish medical history and the sections on neurological diseases in Cerrahiyyetü'l Haniyye are of great importance in neurosurgery. Today, he is justified as a pioneer of surgery, an investigator and a medical illustrator in the early period of Ottoman Empire. His atlas is a modification of original contributions from earlier treatises.

  3. On the photoelectron velocity-map imaging of lutetium monoxide anion LuO(-).

    PubMed

    Liu, Zhiling; Xie, Hua; Li, Quanjiang; Qin, Zhengbo; Cong, Ran; Wu, Xia; Tang, Zichao; Fan, Hongjun

    2014-01-21

    We report a combined photoelectron velocity-map imaging spectroscopy and density functional theory investigation on lutetium monoxide anion. Transition between the X (1)Σ(+) anion electronic ground state and the neutral X (2)Σ(+) electronic ground state is observed. Vibrationally resolved spectra were obtained at four different photon energies, providing a wealth of spectroscopic information for the electronic ground states of the anionic lutetium monoxide and corresponding neutral species. Franck-Condon simulations of the ground-state transition are performed to assign vibrational structure in the spectra and to assist in identifying the observed spectral bands. The electronic ground state of LuO(-) is found to have a vibrational frequency of 743 ± 10 cm(-1) and an equilibrium bond length of 1.841 Å. The electron affinity of LuO is measured to be 1.624 ± 0.002 eV. The fundamental frequency of ground-state LuO is estimated to be 839 ± 10 cm(-1).

  4. On the photoelectron velocity-map imaging of lutetium monoxide anion LuO{sup −}

    SciTech Connect

    Liu, Zhiling; Xie, Hua; Qin, Zhengbo; Cong, Ran; Wu, Xia; Tang, Zichao Fan, Hongjun; Li, Quanjiang

    2014-01-21

    We report a combined photoelectron velocity-map imaging spectroscopy and density functional theory investigation on lutetium monoxide anion. Transition between the X {sup 1}Σ{sup +} anion electronic ground state and the neutral X {sup 2}Σ{sup +} electronic ground state is observed. Vibrationally resolved spectra were obtained at four different photon energies, providing a wealth of spectroscopic information for the electronic ground states of the anionic lutetium monoxide and corresponding neutral species. Franck-Condon simulations of the ground-state transition are performed to assign vibrational structure in the spectra and to assist in identifying the observed spectral bands. The electronic ground state of LuO{sup −} is found to have a vibrational frequency of 743 ± 10 cm{sup −1} and an equilibrium bond length of 1.841 Å. The electron affinity of LuO is measured to be 1.624 ± 0.002 eV. The fundamental frequency of ground-state LuO is estimated to be 839 ± 10 cm{sup −1}.

  5. Atomic and electronic structures of lutetium oxide Lu{sub 2}O{sub 3}

    SciTech Connect

    Kaichev, V. V.; Asanova, T. I.; Erenburg, S. B.; Perevalov, T. V.; Shvets, V. A.; Gritsenko, V. A.

    2013-02-15

    The chemical composition, electronic structure, structure, and physical properties a lutetium oxide Lu{sub 2}O{sub 3} film are studied by X-ray photoelectron spectroscopy, ellipsometry, and X-ray absorption spectroscopy. The short-range order in Lu{sub 2}O{sub 3} is found to correspond to its cubic modification. The binding energies of the 1s and 2p levels of oxygen and the 4d{sub 5/2} and 4f{sub 7/2} levels of lutetium are 529.2, 5.0 and 7.4, 195.9 eV, respectively. The energy gap determined from the electron energy loss spectrum of the film is 5.9 eV. The electron energy loss spectra have two peaks at 17.4 and 22.0 eV, which can be attributed to the excitation of bulk plasma oscillations. The dispersion of the refractive index is measured by spectral ellipsometry. The refractive index is shown to increase from 1.82 at 1.5 eV to 2.18 at 5.0 eV, and the high-frequency permittivity of Lu{sub 2}O{sub 3} is 3.31.

  6. Lu-Hf total-rock age for the Amitsoq gneisses, West Greenland

    NASA Technical Reports Server (NTRS)

    Pettingill, H. S.; Patchett, P. J.

    1981-01-01

    Lu-Hf total-rock data for the Amitsoq gneisses of West Greenland yield an age of 3.55 + or - 0.22 billion years, based on the decay constant for Lu-176 of 1.96 x 10 to the -11th/year, and an initial Hf-176/Hf-177 ratio of 0.280482 + or - 33. The result is in good agreement with Rb-Sr total-rock and U-Pb zircon ages. In spite of severe metamorphism of the area at 2.9 billion years, zircons from two of the samples have remained on the total-rock line, and define points close to the initial Hf ratio. The initial Hf-176/Hf-177 lies close to a chondritic Hf isotopic evolution curve from 4.55 billion years to present. This is consistent with the igneous precursors to the Amitsoq gneisses having been derived from the mantle at or shortly before 3.6 billion years. Anomalous relationships between Hf concentration and the Lu-176/Hf-177 ratio may suggest that trace element abundances in the Amitsoq gneisses are partly controlled by processes related to metamorphism.

  7. E -type noncollinear magnetic ordering in multiferroic o -LuMnO3

    NASA Astrophysics Data System (ADS)

    Mukherjee, Saumya; Dönni, Andreas; Nakajima, Taro; Mitsuda, Setsuo; Tachibana, Makoto; Kitazawa, Hideaki; Pomjakushin, Vladimir; Keller, Lukas; Niedermayer, Christof; Scaramucci, Andrea; Kenzelmann, Michel

    2017-03-01

    Multiferroic orthorhombic o -LuMnO3 exhibits large ferroelectric polarization induced by an E -type magnetic order. Recently, the E -type magnetic phase in LuMnO3 was proposed to feature magnetic moments tilted away from the collinear ordering. We employed neutron diffraction to determine the symmetry of the magnetic order in o -LuMnO3 . We observed that below TN=39 K, the Mn3 + spins order into an incommensurate amplitude-modulated phase that obeys the Pbnm crystal symmetry and is paraelectric. The incommensurate phase locks into a commensurate phase at TC=35.5 K described by a fully antiferromagnetic and noncollinear E -type order. This noncollinear E -type ordering breaks the spatial inversion symmetry and induces a spontaneous polarization at TC. At T =2 K, an appreciably large electric polarization was observed similar to that of other orthorhombic manganites featuring E -type magnetic order. We also present a Pbnm symmetry-allowed Dzyaloshinskii-Moriya interaction that explains the noncollinear E -type order in the commensurate phase. These results are in qualitative agreement with the type of distortions from collinear E -type antiferromagnetic order found using Monte Carlo simulation for rare-earth manganites [M. Mochizuki et al., Phys. Rev. B 84, 144409 (2011), 10.1103/PhysRevB.84.144409].

  8. Critical magnetic scattering in geometric frastrated multiferroic LuMnO3

    NASA Astrophysics Data System (ADS)

    Yano, Shinichiro; Li, Bing; Louca, Despina; Qiu, Yiming; Copley, John

    2013-03-01

    The coexistence of competing order parameters in the class of materials referred to as the multiferroics is of great interest. The hexagonal manganites AMnO3 (A = Y, Lu, Ho and Yb) with the P63cm space group exhibit a ferroelectric transition, at very high temperatures, typically ~ 1000 K, while the antiferromagnetic transition, TN, occurs at ~ 100K. Earlier studies on YMnO3 and LuMnO3 using neutron scattering on single crystals showed that diffuse scattering is present around the forbidden nuclear (100) Bragg peak which corresponds to Q=1.20 Å-1.Its intensity rises very sharply and drops just around TN. We performed inelastic neutron scattering measurement on a powder sample of LuMnO3 form 4 to 250 K using the DCS at NIST. Strong inelastic intensity, not due to magnon excitations, is observed at Q=1.32 and 2.50 Å-1. With cooling, the intensity gradually rises and reaches a peak around 100 K. Below, it drops drastically once the system orders. This kind of scattering is due to critical scattering arising from magnetic fluctuations above TN. The S(Q, ω) is asymmetric suggesting that the Mn spin correlations are mosmost likely 2-dimensional in nature.

  9. Enhanced Multiferroicity in LuFeO3 Through Sc Doping

    NASA Astrophysics Data System (ADS)

    Disseler, Steven; Oh, Yoon Seok; Hu, Rongwei; Luo, Xuan; Lynn, Jeff; Cheong, Sang-Wook; Ratcliff, William

    2015-03-01

    Hexagonal manganites of the type RMnO3 are well known examples of single-phase multiferroic materials, but suffer from low magnetic ordering temperatures and weak magnetoelectric coupling making them unsuitable for implementation in devices. Recently, the isostructural ferrites RFeO3 have been proposed as promising materials to exhibit greatly enhanced magnetic properties, including a much stronger coupling mechanism between ferromagnetic moment and ferroelectic polarization. Here we present a magnetometry and neutron scattering investigation of LuFeO3 forced into the ferroelectric structure through Sc-doping. We find the magnetic ordering temperature dramatically increases relative to pure hexagonal LuFeO3 and LuMnO3, as well as an unusual spin-reorientation at low temperatures. We will discuss possible mechanisms for this reorientation and how it provides insight into the enhanced magnetic properties Limit of the RFeO3 series. Supported in part by DOE Grant No. DE-FG02-07ER46382.

  10. Angle-dependent magnetoresistance and quantum oscillations in high-mobility semimetal LuPtBi.

    PubMed

    Xu, Guizhou; Hou, Zhipeng; Wang, Yue; Zhang, Xiaoming; Zhang, Hongwei; Liu, Enke; Xi, X; Xu, Feng; Wu, Guangheng; Zhang, Xixiang; Wang, Wenhong

    2017-03-14

    The recent discovery of ultrahigh mobility and large positive magnetoresistance in topologically non-trivial Half-Heusler semimetal LuPtBi provides a unique playground for studying exotic physics and significant perspective for device applications. As an fcc-structured electron-hole-compensated semimetal, LuPtBi theoretically exhibits six symmetrically arranged anisotropic electron Fermi pockets and two nearly-spherical hole pockets, offering the opportunity to explore the physics of Fermi surface with a simple angle-related magnetotransport properties. In this work, through the angle-dependent transverse magnetoresistance measurements, in combination with high-field SdH quantum oscillations, we achieved to map out a Fermi surface with six anisotropic pockets in the high-temperature and low-field regime, and furthermore, identify a possible magnetic field driven Fermi surface change at lower temperatures. Reasons account for the Fermi surface change in LuPtBi are discussed in terms of the field-induced electron evacuation due to Landau quantization.

  11. Structural characterization of Lu1.8Y0.2SiO5 crystals

    NASA Astrophysics Data System (ADS)

    Chiriu, Daniele; Faedda, Nicola; Lehmann, Alessandra Geddo; Ricci, Pier Carlo; Anedda, Alberto; Desgreniers, Serge; Fortin, Emery

    2007-08-01

    The structural and vibrational properties of Lu1.8Y0.2SiO5 (LYSO) single crystals were investigated by means of Raman spectroscopy and x-ray diffraction measurements. Unit cell parameters and bond lengths were determined by Rietveld refinement of the collected x-ray diffraction powder spectra. By comparison with the vibrational spectra of the parent compounds Lu2SiO5 and Y2SiO5 and by using polarized Raman measurements, we propose the assignment of the principal vibrational modes of LYSO crystals. The strict connection of Raman spectra of the LYSO solid solution and of the pure lutetium and yttrium crystals, as well as the analysis of the polarized measurements, confirms that LYSO structure adopts the C2/c space group symmetry. The structural analogies of LYSO with the pure compound Lu2SiO5 are further shown by means of high pressure Raman spectroscopy, and the possibility of considering the LYSO crystal analogous to the LSO structure with a tensile stress between 0.25 and 0.80GPa is discussed.

  12. 177Lu-labeled HPMA Copolymers Utilizing Cathepsin B and S Cleavable Linkers: Synthesis, Characterization and Preliminary In Vivo Investigation in a Pancreatic Cancer Model

    PubMed Central

    Ogbomo, Sunny M.; Shi, Wen; Wagh, Nilesh K; Zhou, Zhengyuan; Brusnahan, Susan K.; Garrison, Jered C.

    2013-01-01

    Introduction A major barrier to the advancement of therapeutic nanomedicines has been the non-target toxicity caused by the accumulation of the drug delivery systems in organs associated with the reticuloendothelial system, particularly the liver and spleen. Herein, we report the development of peptide based metabolically active linkers (MALs) that are enzymatically cleaved by cysteine cathepsin B and S, two proteases highly expressed in the liver and spleen. The overall goal of this approach is to utilize the MALs to lower the non-target retention and toxicity of radiolabeled drug delivery systems, thus resulting in higher diagnostic and radiotherapeutic efficacy. Methods In this study three MALs (MAL0, MAL1 and MAL2) were investigated. MAL1 and MAL2 are composed of known substrates of cathepsin B and S, respectively, while MAL0 is a non-cleavable control. Both MAL1 and MAL2 were shown to undergo enzymatic cleavage with the appropriate cathepsin protease. Subsequent to conjugation to the HPMA copolymer and radiolabeling with 177Lu, the peptide-polymer conjugates were renamed 177Lu- metabolically active copolymers (177Lu-MACs) with the corresponding designation 177Lu-MAC0, 177Lu-MAC1 and 177Lu-MAC2. Results In vivo evaluation of the 177Lu-MACs was performed in a HPAC human pancreatic cancer xenograft mouse model. 177Lu-MAC1 and 177Lu-MAC2 demonstrated 3.1 and 2.1 fold lower liver retention, respectively, compared to control (177Lu-MAC0) at 72 h post-injection. With regard to spleen retention, 177Lu-MAC1 and 177Lu-MAC2 each exhibited a nearly fourfold lower retention, relative to control, at the 72 h time point. However, the tumor accumulation of the 177Lu-MAC0 was two to three times greater than 177Lu-MAC1 and 177Lu-MAC2 at the same time point. The MAL approach demonstrated the capability of substantially reducing the non-target retention of the 177Lu-labeled HPMA copolymers. Conclusions While further studies are needed to optimize the pharmacokinetics of the 177Lu

  13. Peculiarities of thermoelectric half-Heusler phase formation in Gd-Ni-Sb and Lu-Ni-Sb ternary systems

    SciTech Connect

    Romaka, V.V.; Romaka, L.; Horyn, A.; Rogl, P.; Stadnyk, Yu; Melnychenko, N.; Orlovskyy, M.; Krayovskyy, V.

    2016-07-15

    The phase equilibria in the Gd–Ni–Sb and Lu-Ni-Sb ternary systems were studied at 873 K by X-ray and metallographic analyses in the whole concentration range. The interaction of the elements in the Gd–Ni–Sb system results the formation of five ternary compounds at investigated temperature: Gd{sub 5}Ni{sub 2}Sb (Mo{sub 5}SiB{sub 2}-type), Gd{sub 5}NiSb{sub 2} (Yb{sub 5}Sb{sub 3}-type), GdNiSb (MgAgAs-type), Gd{sub 3}Ni{sub 6}Sb{sub 5} (Y{sub 3}Ni{sub 6}Sb{sub 5}-type), and GdNi{sub 0.72}Sb{sub 2} (HfCuSi{sub 2}-type). At investigated temperature the Lu-Ni-Sb system is characterized by formation of the LuNiSb (MgAgAs-type), Lu{sub 5}Ni{sub 2}Sb (Mo{sub 5}SiB{sub 2}-type), and Lu{sub 5}Ni{sub 0.56}Sb{sub 2.44} (Yb{sub 5}Sb{sub 3}-type) compounds. The disordering in the crystal structure of half-Heusler GdNiSb and LuNiSb was revealed by EPMA and studied by means of Rietveld refinement and DFT modeling. The performed electronic structure calculations are in good agreement with electrical transport property studies. - Graphical abstract: Crystal structure model and electron localization function of Lu{sub 5}Ni{sub 2}Sb. Display Omitted - Highlights: • Gd-Ni-Sb and Lu-Ni-Sb phase diagrams were constructed at 873 K. • GdNiSb and LuNiSb are characterized by disordered crystal structure. • Crystal structure optimization with DFT calculations confirmed crystal structure disorder in GdNiSb and LuNiSb.

  14. Ages of Sevier thrusting from dating of metamorphic garnet using the Lu-Hf method

    NASA Astrophysics Data System (ADS)

    Cruz-Uribe, A. M.; Hoisch, T. D.; Wells, M. L.; Vervoort, J. D.

    2008-12-01

    Combined thermodynamic modeling of garnet growth zoning and Lu-Hf dating of garnet yield well-constrained pressure-temperature-time (PTt) paths. Here we present PTt paths from amphibolite-facies pelitic garnet from the Raft River-Albion-Grouse Creek metamorphic core complex that constrain the timing of thrusting in the hinterland of the Sevier thrust belt. Three general times of thrust burial are indicated: 150, 138, and 85 Ma. Lu-Hf garnet dating of burial-related garnet growth in the Raft River Mountains yielded a Late Jurassic age of 149.9 ± 1.2 Ma (2σ, MSWD = 1.1) based on three garnet fractions and a whole rock. A PT path from the schist of Mahogany Peaks in the Albion Range, Idaho, records an isothermal pressure increase indicating growth during thrusting. Lu-Hf dating of garnet from the same rock yielded an Early Cretaceous age of 138.7 ± 0.7 Ma (2σ, MSWD = 1.6) based on seven garnet fractions. An additional PT path from a nearby outcrop also records an isothermal pressure increase and a similar Lu-Hf garnet age of 132.1 ± 5.1 Ma (2σ, MSWD = 9.5) based on three garnet fractions and a whole rock. PT paths of multiple garnet grains from the schist of Stevens Spring in the Grouse Creek Mountains, Utah, exhibit isothermal pressure increases and yielded a Lu-Hf garnet age of 85.5 ± 1.9 Ma (2σ, MSWD = 3.9) based on five garnet fractions and a whole rock. The Late Jurassic burial event recorded in the Raft River Mountains is older than the ages of inception of thrusting of the western thrusts of the Sevier fold-thrust belt including the Canyon Range and Paris - Willard thrusts, but consistent with an eastward progression in initial shortening in the orogenic wedge and development of an inferred thrust load responsible for the retroarc Morrison Formation basin. Early Cretaceous hinterland burial recorded in the Albion Range is permissively coeval with activity on the Willard and Canyon Range thrusts. Finally, renewed hinterland thrust burial during the Late

  15. Gamma camera calibration and validation for quantitative SPECT imaging with (177)Lu.

    PubMed

    D'Arienzo, M; Cazzato, M; Cozzella, M L; Cox, M; D'Andrea, M; Fazio, A; Fenwick, A; Iaccarino, G; Johansson, L; Strigari, L; Ungania, S; De Felice, P

    2016-06-01

    Over the last years (177)Lu has received considerable attention from the clinical nuclear medicine community thanks to its wide range of applications in molecular radiotherapy, especially in peptide-receptor radionuclide therapy (PRRT). In addition to short-range beta particles, (177)Lu emits low energy gamma radiation of 113keV and 208keV that allows gamma camera quantitative imaging. Despite quantitative cancer imaging in molecular radiotherapy having been proven to be a key instrument for the assessment of therapeutic response, at present no general clinically accepted quantitative imaging protocol exists and absolute quantification studies are usually based on individual initiatives. The aim of this work was to develop and evaluate an approach to gamma camera calibration for absolute quantification in tomographic imaging with (177)Lu. We assessed the gamma camera calibration factors for a Philips IRIX and Philips AXIS gamma camera system using various reference geometries, both in air and in water. Images were corrected for the major effects that contribute to image degradation, i.e. attenuation, scatter and dead- time. We validated our method in non-reference geometry using an anthropomorphic torso phantom provided with the liver cavity uniformly filled with (177)LuCl3. Our results showed that calibration factors depend on the particular reference condition. In general, acquisitions performed with the IRIX gamma camera provided good results at 208keV, with agreement within 5% for all geometries. The use of a Jaszczak 16mL hollow sphere in water provided calibration factors capable of recovering the activity in anthropomorphic geometry within 1% for the 208keV peak, for both gamma cameras. The point source provided the poorest results, most likely because scatter and attenuation correction are not incorporated in the calibration factor. However, for both gamma cameras all geometries provided calibration factors capable of recovering the activity in

  16. Importance of the Lu-Hf isotopic system in studies of planetary chronology and chemical evolution

    USGS Publications Warehouse

    Patchett, P.J.

    1983-01-01

    The 176Lu-176Hf isotope method and its applications in earth sciences are discussed. Greater fractionation of Lu/Hf than Sm/Nd in planetary magmatic processes makes 176Hf 177Hf a powerful geochemical tracer. In general, proportional variations of 176Hf 177Hf exceed those of 143Nd l44Nd by factors of 1.5-3 in terrestrial and lunar materials. Lu-Hf studies therefore have a major contribution to make in understanding of terrestrial and other planetary evolution through time, and this is the principal importance of Lu-Hf. New data on basalts from oceanic islands show unequivocally that whereas considerable divergences occur in 176Hf 177Hf- 87Sr 86Sr and 143Nd l44Nd- 87Sr 86Sr diagrams, 176Hf 177Hf and 143Nd 144Nd display a single, linear isotopic variation in the suboceanic mantle. These discordant 87Sr 86Sr relationships may allow, with the acquisition of further Hf-Nd-Sr isotopic data, a distinction between processes such as mantle metasomatism, influence of seawater-altered material in the magma source, or recycling of sediments into the mantle. In order to evaluate the Hf-Nd isotopic correlation in terms of mantle fractionation history, there is a need for measurements of Hf distribution coefficients between silicate minerals and liquids, and specifically for a knowledge of Hf behavior in relation to rareearth elements. For studying ancient terrestrial Hf isotopic variations, the best quality Hf isotope data are obtained from granitoid rocks or zircons. New data show that very U-Pb discordant zircons may have upwardly-biased 176Hf 177Hf, but that at least concordant to slightly discordant zircons appear to be reliable carriers of initial 176Hf 177Hf. Until the controls on addition of radiogenic Hf to zircon are understood, combined zircon-whole rock studies are recommended. Lu-Hf has been demonstrated as a viable tool for dating of ancient terrestrial and extraterrestrial samples, but because it offers little advantage over existing methods, is unlikely to find

  17. Excitation function for deuteron induced nuclear reactions on natural ytterbium for production of high specific activity 177g Lu in no-carrier-added form for metabolic radiotherapy.

    PubMed

    Manenti, Simone; Groppi, Flavia; Gandini, Andrea; Gini, Luigi; Abbas, Kamel; Holzwarth, Uwe; Simonelli, Federica; Bonardi, Mauro

    2011-01-01

    Deuteron-induced nuclear reactions for generation of no-carrier-added Lu radionuclides were investigated using the stacked-foil activation technique on natural Yb targets at energies up to E(d)=18.18 MeV. Excitation functions of the reactions (nat)Yb(d,xn)(169,170,171,172,173,174g,174m,176m,177g)Lu and (nat)Yb(d,pxn)(169,175,177)Yb have been measured, among them three ((169)Lu, (174m)Lu and (176m)Lu) are reported for the first time. The upper limit of the contamination from the long-lived metastable level (177m)Lu was evaluated too. Thick-target yields for all investigated radionuclides are calculated.

  18. L'hémangiopéricytome méningé: une tumeur intracrânienne rare - à propos d'un cas

    PubMed Central

    Errachdi, Amal; Asabbane, Amal; Epala, Brice Nkoua; Hemmich, Mariem; Kabbali, Naoual; Diakité, Adama; Kebdani, Tayeb; Benjaafar, Noureddine

    2014-01-01

    L'hémangiopéricytomeméningé intracrânien est une tumeur rare qui représente moins de 1% des tumeurs cérébrales. Son aspect radiologique peut être trompeur et faire porter à tort le diagnostic de méningiome. Le diagnostic de confirmation est histologique. Le traitement repose sur la chirurgie et la radiothérapie. L’évolution après traitement est caractérisée par la fréquence des récidives et des métastases à distance, imposant un suivi prolongé. Nous rapportons l'observation d'un patient présentant un hémangiopéricytome intracrânien dont l’évolution était marquée par l'absence de récidive à 4 ans de suivi. PMID:25170367

  19. Promise and Pitfalls of Lu/Hf-Sm/Nd Garnet Geochronology

    NASA Astrophysics Data System (ADS)

    King, R. L.; Vervoort, J. D.; Kohn, M. J.; Zirakparvar, N. A.; Hart, G. L.; Corrie, S. L.; Cheng, H.

    2007-12-01

    Our ability to routinely measure Lu-Hf and Sm-Nd isotopes in garnet allows broad new applications in geochronology, petrology, and tectonics. However, applications of these data can be limited by challenges in interpreting the petrologic record and preparing garnets for analysis. Here, we examine petrologic and chemical pitfalls encountered in garnet geochronology. Petrologic factors influencing trace element compositions in garnet include reactions that modify REE availability and partitioning (1,2), kinetically limited transfer of REEs to garnet (3), and bulk compositional heterogeneities (4). Interpreting the effects of these processes on Sm/Nd and Lu/Hf ages requires characterizing REE zonation prior to isotope analysis and age interpretation. Because garnet fractions are traditionally picked from crushed samples without regard to intracrystalline origins or chemistries, isochrons will represent mixtures derived to varying degrees from all periods of garnet growth. While measured zoning might generally indicate what garnet portion dominates the Lu/Hf or Sm/Nd budget, traditional mineral separation will rarely realize the chronologic potential afforded by high precision Hf and Nd isotope measurements. The potential use of alternative techniques, such as microsampling, necessitates selective digestion and/or leaching to eliminate inclusions within garnet. For Sm/Nd geochronology, H2SO4 leaching removes LREE-rich phosphates (e.g. apatite), but not silicates (e.g. epidote), precluding Sm-Nd dating of some rocks. For Lu/Hf geochronology, ubiquitous zircon microinclusions (c. 1 μm) can significantly disrupt age determinations. Microinclusions cannot be detected optically or separated physically, requiring selective chemical digestion. If complete digestion methods, such as bomb digestion, are used for garnet fractions, then "common Hf" from zircon will be contained in final solutions. These mixed analyses are of dubious utility and will fall into one of two

  20. The Lu-Hf and Sm-Nd isotopic composition of CHUR: Constraints from unequilibrated chondrites and implications for the bulk composition of terrestrial planets

    NASA Astrophysics Data System (ADS)

    Bouvier, Audrey; Vervoort, Jeffrey D.; Patchett, P. Jonathan

    2008-08-01

    The Lutetium-Hafnium radiogenic isotopic system is widely used as a chronometer and tracer of planetary evolution. In order for this isotopic system to fulfill its potential in planetary studies, the Lu-Hf system parameters need to be more tightly constrained, in particular the Lu-Hf isotopic composition of the chondritic uniform reservoir (CHUR) and, by extension, the bulk silicate Earth (BSE). We present new Lu-Hf and Sm-Nd isotopic compositions of unequilibrated carbonaceous, ordinary, and enstatite chondrites of petrologic types 1, 2, and 3 which define a narrow range of Lu/Hf ratios (3%) identical with that of Sm/Nd. This contrasts with previously published data from mostly equilibrated ordinary chondrites of petrologic types 4, 5, and 6 which have a much larger range in Lu/Hf (28%). This heterogeneity has hampered an unambiguous choice for the Lu-Hf isotopic composition of CHUR. Our new determinations of Lu-Hf CHUR parameters are 176Lu/177Hf = 0.0336 ± 1 and 176Hf/177Hf = 0.282785 ± 11 (2σm), which are higher than previous estimates and, together with average Sm-Nd chondrite compositions of unequilibrated chondrites of 147Sm/144Nd = 0.1960 ± 4 and 143Nd/144Nd = 0.512630 ± 11 (2σm), now provide firm constraints on the chondritic parameters for both Lu-Hf and Sm-Nd isotopic systems. A comparison of Lu-Hf and Sm-Nd data show that terrestrial planets, as well as early differentiated planetesimals, converge toward a common initial Hf and Nd isotope composition corresponding to the average of chondrites. Finally, a compilation of Lu-Hf isotopic data of unequilibrated and equilibrated chondrites demonstrates that the 176Lu decay decay-constant value cannot be resolved by age comparison on metamorphosed or shocked planetary materials which have a complex history.

  1. Synthesis of Oligosaccharides Derived from Lactulose (OsLu) Using Soluble and Immobilized Aspergillus oryzae β-Galactosidase

    PubMed Central

    Cardelle-Cobas, Alejandra; Olano, Agustin; Irazoqui, Gabriela; Giacomini, Cecilia; Batista-Viera, Francisco; Corzo, Nieves; Corzo-Martínez, Marta

    2016-01-01

    β-Galactosidase from Aspergillus oryzae offers a high yield for the synthesis of oligosaccharides derived from lactulose (OsLu) by transgalactosylation. Oligosaccharides with degree of polymerization (DP) ≥ 3 have shown to possess higher in vitro bifidogenic effect than di- and tetrasaccharides. Thus, in this work, an optimization of reaction conditions affecting the specific selectivity of A. oryzae β-galactosidase for synthesis of OsLu has been carried out to enhance OsLu with DP ≥ 3 production. Assays with β-galactosidase immobilized onto a glutaraldehyde–agarose support were also carried out with the aim of making the process cost-effective and industrially viable. Optimal conditions with both soluble and immobilized enzyme for the synthesis of OsLu with DP ≥ 3 were 50 °C, pH 6.5, 450 g/L of lactulose, and 8 U/mL of enzyme, reaching yields of ca. 50% (w/v) of total OsLu and ca. 20% (w/v) of OsLu with DP 3, being 6′-galactosyl-lactulose the major one, after a short reaction time. Selective formation of disaccharides, however, was favored at 60 °C, pH 4.5, 450 g/L of lactulose and 8 U/mL of enzyme. Immobilization increased the enzymatic stability to temperature changes and allowed to reuse the enzyme. We can conclude that the use, under determined optimal conditions, of the A. oryzae β-galactosidase immobilized on a support of glutaraldehyde–agarose constitutes an efficient and cost-effective alternative to the use of soluble β-galactosidases for the synthesis of prebiotic OsLu mixtures. PMID:27014684

  2. Synthesis of Oligosaccharides Derived from Lactulose (OsLu) Using Soluble and Immobilized Aspergillus oryzae β-Galactosidase.

    PubMed

    Cardelle-Cobas, Alejandra; Olano, Agustin; Irazoqui, Gabriela; Giacomini, Cecilia; Batista-Viera, Francisco; Corzo, Nieves; Corzo-Martínez, Marta

    2016-01-01

    β-Galactosidase from Aspergillus oryzae offers a high yield for the synthesis of oligosaccharides derived from lactulose (OsLu) by transgalactosylation. Oligosaccharides with degree of polymerization (DP) ≥ 3 have shown to possess higher in vitro bifidogenic effect than di- and tetrasaccharides. Thus, in this work, an optimization of reaction conditions affecting the specific selectivity of A. oryzae β-galactosidase for synthesis of OsLu has been carried out to enhance OsLu with DP ≥ 3 production. Assays with β-galactosidase immobilized onto a glutaraldehyde-agarose support were also carried out with the aim of making the process cost-effective and industrially viable. Optimal conditions with both soluble and immobilized enzyme for the synthesis of OsLu with DP ≥ 3 were 50 °C, pH 6.5, 450 g/L of lactulose, and 8 U/mL of enzyme, reaching yields of ca. 50% (w/v) of total OsLu and ca. 20% (w/v) of OsLu with DP 3, being 6'-galactosyl-lactulose the major one, after a short reaction time. Selective formation of disaccharides, however, was favored at 60 °C, pH 4.5, 450 g/L of lactulose and 8 U/mL of enzyme. Immobilization increased the enzymatic stability to temperature changes and allowed to reuse the enzyme. We can conclude that the use, under determined optimal conditions, of the A. oryzae β-galactosidase immobilized on a support of glutaraldehyde-agarose constitutes an efficient and cost-effective alternative to the use of soluble β-galactosidases for the synthesis of prebiotic OsLu mixtures.

  3. 177Lu-DOTA-HH1, a Novel Anti-CD37 Radio-Immunoconjugate: A Study of Toxicity in Nude Mice

    PubMed Central

    Repetto-Llamazares, Ada H. V.; Larsen, Roy H.; Giusti, Anna Maria; Riccardi, Elena; Bruland, Øyvind S.; Selbo, Pål Kristian; Dahle, Jostein

    2014-01-01

    Background CD37 is an internalizing B-cell antigen expressed on Non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia cells (CLL). The anti-CD37 monoclonal antibody HH1 was conjugated to the bifunctional chelator p-SCN-Bn-DOTA and labelled with the beta-particle emitting radionuclide 177Lu creating the radio-immunoconjugate (RIC) 177Lu-DOTA-HH1 (177Lu-HH1, trade name Betalutin). The present toxicity study was performed prior to initiation of clinical studieswith 177Lu-HH1. Methodology/Principal Findings Nude mice with or without tumor xenografts were treated with 50 to 1000 MBq/kg 177Lu- HH1 and followed for clinical signs of toxicity up to ten months. Acute, life threatening bone marrow toxicity was observed in animals receiving 800 and 1000 MBq/kg 177Lu-HH1. Significant changes in serum concentrations of liver enzymes were evident for treatment with 1000 MBq/kg 177Lu-HH1. Lymphoid depletion, liver necrosis and atrophy, and interstitial cell hyperplasia of the ovaries were also observed for mice in this dose group. Conclusions/Significance 177Lu-DOTA-HH1 was well tolerated at dosages about 10 times above those considered relevant for radioimmunotherapy in patients with B-cell derived malignancies.The toxicity profile was as expected for RICs. Our experimental results have paved the way for clinical evaluation of 177Lu-HH1 in NHL patients. PMID:25068508

  4. Biodistribution, Pharmacokinetics, and Dosimetry of (177)Lu-, (90)Y-, and (111)In-Labeled Somatostatin Receptor Antagonist OPS201 in Comparison to the Agonist (177)Lu-DOTATATE: The Mass Effect.

    PubMed

    Nicolas, Guillaume P; Mansi, Rosalba; McDougall, Lisa; Kaufmann, Jens; Bouterfa, Hakim; Wild, Damian; Fani, Melpomeni

    2017-09-01

    Radiolabeled somatostatin receptor (SSTR) antagonists have shown in vivo higher uptake in SSTR-expressing tumors than agonists. In this preclinical study, the SSTR2 antagonist OPS201 (DOTA-JR11; DOTA-[Cpa-c(DCys-Aph(Hor)-DAph(Cbm)-Lys-Thr-Cys)-DTyr-NH2]) labeled with (177)Lu, (90)Y, and (111)In was compared with the SSTR2 agonist (177)Lu-DOTATATE. Methods: Biodistribution, pharmacokinetics, SPECT/CT, and dosimetry studies were performed to assess the bioequivalence of all radiotracers. Use of escalated peptide mass and nephroprotective agents were systematically investigated. Results: The tumor residence time was 15.6 h (13.4-17.7) for (177)Lu-OPS201 (10 pmol) and 6.4 h (5.4-7.3) for (177)Lu-DOTATATE, resulting in a 2.5-times-higher tumor dose for the antagonist than for the agonist (0.854 vs. 0.333 mGy/MBq for a 4-cm tumor). The overall tumor-to-kidney dose ratio was approximately 24% and 32% higher for (177)Lu-OPS201 than for (90)Y-OPS201 and (177)Lu-DOTATATE, respectively. (111)In-OPS201 had a biodistribution significantly different from (90)Y-OPS201 and is therefore not a surrogate for (90)Y-OPS201 dosimetry studies. Importantly, and in contrast to (177)Lu-DOTATATE, injection of 10, 200, and 2,000 pmol of (177)Lu-OPS201 did not cause any relevant tumor saturation, with tumor uptake 4 h after injection: 23.9, 24.9, and 18.8 percentage of injected activity per gram of tissue (%IA/g), respectively, for the antagonist (P > 0.05), as compared with 17.8, 12.0, and 9.9 %IA/g for the agonist (P < 0.05). Increasing the peptide mass of (177)Lu-OPS201 from 10 to 200 pmol drastically decreased the effective dose from 0.0908 to 0.0184 mSv/MBq and decreased the uptake in the liver, bone marrow, and all SSTR2-expressing organs; thus, the therapeutic index improved considerably. Lysine and succinylated gelatine, alone or in combination, significantly reduced the renal dose of (177)Lu-OPS201 compared with the control group, by 45%, 25%, and 40%, respectively (P < 0.05). The

  5. Synthesis and Evaluation of a New Bifunctional NETA Chelate for Molecular Targeted Radiotherapy Using 90Y or 177Lu

    PubMed Central

    Kang, Chi Soo; Chen, Yunwei; Lee, Hyunbeom; Liu, Dijie; Sun, Xiang; Kweon, Junghun; Lewis, Michael R.; Chong, Hyun-Soon

    2015-01-01

    Introduction Therapeutic potential of β-emitting cytotoxic radionuclides 90Y and 177Lu have been demonstrated in numerous preclinical and clinical trials. A bifunctional chelate that can effectively complex with the radioisotopes is a critical component for molecular targeted radiotherapy 90Y and 177Lu. A new bifunctional chelate 5p-C-NETA with a relatively long alkyl spacer between the chelating backbone and the functional unit for conjugation to a tumor targeting moiety was synthesized. 5p-C-NETA was conjugated to a model targeting moiety, a cyclic Arg-Gly-Asp-D-Tyr-Lys (RGDyK) peptide binding integrin αvβ3 protein overexpressed on various cancers. 5p-C-NETA was conjugated to c(RGDyK) peptide and evaluated for potential use in molecular targeted radiotherapy of 90Y and 177Lu. Methods 5p-C-NETA conjugated with c(RGDyK) was evaluated in vitro for radiolabeling, serum stability, binding affinity, and the result of the in vitro studies of 5p-C-NETA-c(RGDyK) was compared to that of 3p-CNETA-c(RGDyK). 177Lu-5p-C-NETA-c(RGDyK) was further evaluated for in vivo biodistribution using gliobastoma bearing mice. Result The new chelate rapidly and tightly bound to a cytotoxic radioisotope for cancer therapy, 90Y or 177Lu with excellent radiolabeling efficiency and maximum specific activity under mild condition (>99%, RT, <1 min). 90Y- and 177Lu-radiolabeled complexes of the new chelator remained stable in human serum without any loss of the radiolanthanide for 14 days. Introduction of the tumor targeting RGD moiety to the new chelator made little impact on complexation kinetics and stability with 90Y or 177Lu. 177Lu-radiolabeled 5p-C-NETA-c(RGDyK) conjugate was shown to target tumors in mice and produced a favorable in vivo stability profile. Conclusion The results of in vitro and in vivo evaluation suggest that 5p-C-NETA is an effective bifunctional chelate of 90Y and 177Lu that can be applied for generation of versatile molecular targeted radiopharmaceuticals. PMID

  6. Effect of 176Lu intrinsic radioactivity on dual head PET system imaging and data acquisition, simulation, and experimental measurements.

    PubMed

    Efthimiou, Nikos; Loudos, George; Karakatsanis, Nicolas A; Panayiotakis, George S

    2013-11-01

    In this work, the authors aim for the estimation of the effect of (176)Lu intrinsic radioactivity on the performance of a dual head PET system dedicated to small animal imaging. A prototype camera has been used as a reference system in order to validate two GATE simulation models, which were used for the investigation. The first model includes the (176)Lu intrinsic radioactivity, while the second does not. The two models have been designed in order to provide similar sensitivities, in terms of count rate performance and scatter fraction, in the linear range of activities. In addition, the model with the (176)Lu intrinsic radioactivity, has been validated in terms of background count rate. Different acquisition schemes have been examined in order to determine the optimum conditions to minimize the (176)Lu effects, while maintaining a high trues count rate. In addition, the effect on the image quality, in terms of spatial resolution, signal-to-noise ratio, and minimum detectable activity, was investigated. Both models are in good agreement with the measured data. While, the presence of the (176)Lu altered the dead time of the model, it also affected the singles, trues, and randoms count rates. The noise equivalent count rate curves of the two models indicate that for low activities, the lack of (176)Lu radioactivity leads to better noise properties due to the underestimation of the randoms. Signal-to-noise ratio measurement on coincidence images confirm the aforementioned claim, since the model without the (176)Lu provides better less noisy images. Furthermore, the spatial resolution and the minimum detectable activity are overestimated. It has been proven that the lack of the (176)Lu intrinsic radioactivity has an impact on the design of the simulation model's dead time. Even if there is an alignment with experimental results still the noise properties, for a wide range of activities, are overestimated. In addition, for low activities, better image quality, is

  7. Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

    PubMed Central

    Frost, Sofia H. L.; Frayo, Shani L.; Miller, Brian W.; Orozco, Johnnie J.; Booth, Garrett C.; Hylarides, Mark D.; Lin, Yukang; Green, Damian J.; Gopal, Ajay K.; Pagel, John M.; Bäck, Tom A.; Fisher, Darrell R.; Press, Oliver W.

    2015-01-01

    Purpose Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice. Methods Parallel experiments evaluating the biodistribution, imaging, dosimetry, therapeutic efficacy, and toxicity were performed in female athymic nude mice bearing either Ramos (Burkitt lymphoma) or Granta (mantle cell lymphoma) xenografts, utilizing an anti-CD20 antibody-streptavidin conjugate (1F5-SA) and an 90Y- or 177Lu-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-biotin second step reagent. Results The two radionuclides displayed comparable biodistributions in tumors and normal organs; however, the absorbed radiation dose delivered to tumor was more than twice as high for 90Y (1.3 Gy/MBq) as for 177Lu (0.6 Gy/MBq). More importantly, therapy with 90Y-DOTA-biotin was dramatically more effective than with 177Lu-DOTA-biotin, with 100% of Ramos xenograft-bearing mice cured with 37 MBq 90Y, whereas 0% were cured using identical amounts of 177Lu-DOTA-biotin. Similar results were observed in mice bearing Granta xenografts, with 80% of the mice cured with 90Y-PRIT and 0% cured with 177Lu-PRIT. Toxicities were comparable with both isotopes. Conclusion 90Y was therapeutically superior to 177Lu for streptavidin-biotin PRIT approaches in

  8. Comparative efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

    DOE PAGES

    Frost, Sofia H. L.; Frayo, Shani L.; Miller, Brian W.; ...

    2015-03-18

    Purpose Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targetingmore » either 90Y or 177Lu to human B-cell lymphoma xenografts in mice. Methods Parallel experiments evaluating the biodistribution, imaging, dosimetry, therapeutic efficacy, and toxicity were performed in female athymic nude mice bearing either Ramos (Burkitt lymphoma) or Granta (mantle cell lymphoma) xenografts, utilizing an anti-CD20 antibodystreptavidin conjugate (1F5-SA) and an 90Y- or 177Lu-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-biotin second step reagent. Results The two radionuclides displayed comparable biodistributions in tumors and normal organs; however, the absorbed radiation dose delivered to tumor was more than twice as high for 90Y (1.3 Gy/MBq) as for 177Lu (0.6 Gy/MBq). More importantly, therapy with 90Y-DOTAbiotin was dramatically more effective than with 177Lu-DOTA-biotin, with 100% of Ramos xenograft-bearing mice cured with 37 MBq 90Y, whereas 0% were cured using identical amounts of 177Lu-DOTA-biotin. Similar results were observed in mice bearing Granta xenografts, with 80% of the mice cured with 90Y-PRIT and 0% cured with 177Lu-PRIT. Toxicities were comparable with both isotopes. Conclusion 90Y was therapeutically superior to 177Lu for streptavidin-biotin PRIT

  9. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder.

    PubMed

    Mørk, A; Pehrson, A; Brennum, L T; Nielsen, S Møller; Zhong, H; Lassen, A B; Miller, S; Westrich, L; Boyle, N J; Sánchez, C; Fischer, C W; Liebenberg, N; Wegener, G; Bundgaard, C; Hogg, S; Bang-Andersen, B; Stensbøl, T Bryan

    2012-03-01

    1-[2-(2,4-Dimethylphenyl-sulfanyl)-phenyl]-piperazine (Lu AA21004) is a human (h) serotonin (5-HT)(3A) receptor antagonist (K(i) = 3.7 nM), h5-HT(7) receptor antagonist (K(i) = 19 nM), h5-HT(1B) receptor partial agonist (K(i) = 33 nM), h5-HT(1A) receptor agonist (K(i) = 15 nM), and a human 5-HT transporter (SERT) inhibitor (K(i) = 1.6 nM) (J Med Chem 54:3206-3221, 2011). Here, we confirm that Lu AA21004 is a partial h5-HT(1B) receptor agonist [EC(50) = 460 nM, intrinsic activity = 22%] using a whole-cell cAMP-based assay and demonstrate that Lu AA21004 is a rat (r) 5-HT(7) receptor antagonist (K(i) = 200 nM and IC(50) = 2080 nM). In vivo, Lu AA21004 occupies the r5-HT(1B) receptor and rSERT (ED(50) = 3.2 and 0.4 mg/kg, respectively) after subcutaneous administration and is a 5-HT(3) receptor antagonist in the Bezold-Jarisch reflex assay (ED(50) = 0.11 mg/kg s.c.). In rat microdialysis experiments, Lu AA21004 (2.5-10.0 mg/kg s.c.) increased extracellular 5-HT, dopamine, and noradrenaline in the medial prefrontal cortex and ventral hippocampus. Lu AA21004 (5 mg/kg per day for 3 days; minipump subcutaneously), corresponding to 41% rSERT occupancy, significantly increased extracellular 5-HT in the ventral hippocampus. Furthermore, the 5-HT(3) receptor antagonist, ondansetron, potentiated the increase in extracellular levels of 5-HT induced by citalopram. Lu AA21004 has antidepressant- and anxiolytic-like effects in the rat forced swim (Flinders Sensitive Line) and social interaction and conditioned fear tests (minimal effective doses: 7.8, 2.0, and 3.9 mg/kg). In conclusion, Lu AA21004 mediates its pharmacological effects via two pharmacological modalities: SERT inhibition and 5-HT receptor modulation. In vivo, this results in enhanced release of several neurotransmitters and antidepressant- and anxiolytic-like profiles at doses for which targets in addition to the SERT are occupied. The multimodal activity profile of Lu AA21004 is distinct from that of current

  10. Synthesis and evaluation of a new bifunctional NETA chelate for molecular targeted radiotherapy using(90)Y or(177)Lu.

    PubMed

    Kang, Chi Soo; Chen, Yunwei; Lee, Hyunbeom; Liu, Dijie; Sun, Xiang; Kweon, Junghun; Lewis, Michael R; Chong, Hyun-Soon

    2015-03-01

    Therapeutic potential of β-emitting cytotoxic radionuclides (90)Y and (177)Lu has been demonstrated in numerous preclinical and clinical trials. A bifunctional chelate that can effectively complex with the radioisotopes is a critical component for molecular targeted radiotherapy (90)Y and (177)Lu. A new bifunctional chelate 5p-C-NETA with a relatively long alkyl spacer between the chelating backbone and the functional unit for conjugation to a tumor targeting moiety was synthesized. 5p-C-NETA was conjugated to a model targeting moiety, a cyclic Arg-Gly-Asp-D-Tyr-Lys (RGDyK) peptide binding integrin αvβ3 protein overexpressed on various cancers. 5p-C-NETA was conjugated to c(RGDyK) peptide and evaluated for potential use in molecular targeted radiotherapy of (90)Y and (177)Lu. 5p-C-NETA conjugated with c(RGDyK) was evaluated in vitro for radiolabeling, serum stability, binding affinity, and the result of the in vitro studies of 5p-C-NETA-c(RGDyK) was compared to that of 3p-C-NETA-c(RGDyK). (177)Lu-5p-C-NETA-c(RGDyK) was further evaluated for in vivo biodistribution using gliobastoma bearing mice. The new chelate rapidly and tightly bound to a cytotoxic radioisotope for cancer therapy, (90)Y or (177)Lu with excellent radiolabeling efficiency and maximum specific activity under mild condition (>99%, RT, <1 min). (90)Y- and (177)Lu-radiolabeled complexes of the new chelator remained stable in human serum without any loss of the radiolanthanide for 14 days. Introduction of the tumor targeting RGD moiety to the new chelator made little impact on complexation kinetics and stability with (90)Y or (177)Lu. (177)Lu-radiolabeled 5p-C-NETA-c(RGDyK) conjugate was shown to target tumors in mice and produced a favorable in vivo stability profile. The results of in vitro and in vivo evaluation suggest that 5p-C-NETA is an effective bifunctional chelate of (90)Y and (177)Lu that can be applied for generation of versatile molecular targeted radiopharmaceuticals. Copyright © 2014

  11. Comparative efficacy of 177Lu and 90Y for anti-CD20 pretargeted radioimmunotherapy in murine lymphoma xenograft models.

    PubMed

    Frost, Sofia H L; Frayo, Shani L; Miller, Brian W; Orozco, Johnnie J; Booth, Garrett C; Hylarides, Mark D; Lin, Yukang; Green, Damian J; Gopal, Ajay K; Pagel, John M; Bäck, Tom A; Fisher, Darrell R; Press, Oliver W

    2015-01-01

    Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice. Parallel experiments evaluating the biodistribution, imaging, dosimetry, therapeutic efficacy, and toxicity were performed in female athymic nude mice bearing either Ramos (Burkitt lymphoma) or Granta (mantle cell lymphoma) xenografts, utilizing an anti-CD20 antibody-streptavidin conjugate (1F5-SA) and an 90Y- or 177Lu-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-biotin second step reagent. The two radionuclides displayed comparable biodistributions in tumors and normal organs; however, the absorbed radiation dose delivered to tumor was more than twice as high for 90Y (1.3 Gy/MBq) as for 177Lu (0.6 Gy/MBq). More importantly, therapy with 90Y-DOTA-biotin was dramatically more effective than with 177Lu-DOTA-biotin, with 100% of Ramos xenograft-bearing mice cured with 37 MBq 90Y, whereas 0% were cured using identical amounts of 177Lu-DOTA-biotin. Similar results were observed in mice bearing Granta xenografts, with 80% of the mice cured with 90Y-PRIT and 0% cured with 177Lu-PRIT. Toxicities were comparable with both isotopes. 90Y was therapeutically superior to 177Lu for streptavidin-biotin PRIT approaches in these human lymphoma xenograft

  12. On the structural origin of the single-ion magnetic anisotropy in LuFeO 3

    SciTech Connect

    Cao, Shi; Zhang, Xiaozhe; Paudel, Tula R.; Sinha, Kishan; Wang, Xiao; Jiang, Xuanyuan; Wang, Wenbin; Brutsche, Stuart; Wang, Jian; Ryan, Philip J.; Kim, Jong-Woo; Cheng, Xuemei; Tsymbal, Evgeny Y.; Dowben, Peter A.; Xu, Xiaoshan

    2016-03-16

    The electronic structure for the conduction bands of both hexagonal and orthorhombic LuFeO3 thin films have been measured using x-ray absorption spectroscopy at oxygen K (O K) edge. Dramatic differences in both the spectral features and the linear dichroism are observed. These differences in the spectra can be explained using the differences in crystal field splitting of the metal (Fe and Lu) electronic states and the differences in O 2p-Fe 3d and O 2p-Lu 5d hybridizations. While the oxidation states have not changed, the spectra are sensitive to the changes in the local environments of the Fe3+ and Lu3+ sites in the hexagonal and orthorhombic structures. Using the crystal-field splitting and the hybridizations that are extracted from the measured electronic structures and the structural distortion information, we derived the occupancies of the spin minority states in Fe3+, which are non-zero and uneven. The single ion anisotropy on Fe3+ sites is found to originate from these uneven occupancies of the spin minority states via spin–orbit coupling in LuFeO3.

  13. Crystal growth and optical properties of Gd admixed Ce-doepd Lu2Si2O7 single crystals

    NASA Astrophysics Data System (ADS)

    Horiai, Takahiko; Kurosawa, Shunsuke; Murakami, Rikito; Yamaji, Akihiro; Shoji, Yasuhiro; Ohashi, Yuji; Pejchal, Jan; Kamada, Kei; Yokota, Yuui; Yoshikawa, Akira

    2017-06-01

    Ce-doped Lu2Si2O7 scintillator contains radioactive isotope 176Lu which causes an unwanted intrinsic background signal. The development of scintillators with reduced Lu concentration were required in some applications. In this study, we developed the Gd admixed lutetium pyrosilicate, where the average ion radius at the rare earth site was similar to the Tm3+ ion radius, for which the RE2Si2O7 (RE=Tm, Yb, Lu) crystal structure is stable from room temperature to melting point. We have grown (Cex Lu1-x-y Gdy)2Si2O7 (x=0.01, y=0.00, 0.05, 0.10) single crystals. Their crystal systems were monoclinic with a space group C2/m. The absorption spectra revealed the energy transitions in Ce and Gd ions might be occurred. The light output was degraded and decay time was accelerated comparing the Gd 5% admixed sample with the Gd 10% one.

  14. Structure and phase composition of nanocrystalline Ce{sub 1-x}Lu{sub x}O{sub 2-y}

    SciTech Connect

    Malecka, Malgorzata A.; Kepinski, Leszek Maczka, Miroslaw

    2008-09-15

    The microstructure and phase stability of nanocrystalline mixed oxide Lu{sub x}Ce{sub 1-x}O{sub 2-y} (x=0-1) are described. Nano-sized (3-4 nm) oxide particles were prepared by the reverse microemulsion method. Morphological and structural changes upon heat treatment in an oxidizing atmosphere were studied by transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman and Yb{sup 3+} emission spectroscopy, the latter ion being present as an impurity in the Lu{sub 2}O{sub 3} starting material. Up to 950 deg. C, the samples were single phase, with structure changing smoothly with Lu content from fluorite type (F) to bixbyite type (C). For the samples heated at 1100 deg. C phase separation into coexisting F- and C-type structures was observed for 0.35Lu strongly hinders the crystallite growth of ceria during heat treatment at 800 and 950 deg. C. - Graphical abstract: Phase separation in nanocrystalline Ce{sub 1-x}Lu{sub x}O{sub 2-y} mixed oxide heated in air at 1100 deg. C.

  15. Uniform hollow Lu2O3:Ln (Ln = Eu3+, Tb3+) spheres: facile synthesis and luminescent properties.

    PubMed

    Yang, Piaoping; Gai, Shili; Liu, Yanchao; Wang, Wenxin; Li, Chunxia; Lin, Jun

    2011-03-21

    Uniform hollow Lu(2)O(3):Ln (Ln = Eu(3+), Tb(3+)) phosphors have been successfully prepared via a urea-assisted homogeneous precipitation method using carbon spheres as templates, followed by a subsequent calcination process. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transformed infrared (FT-IR), thermogravimetric and differential thermal analysis (TG-DTA), photoluminescence (PL) spectra, cathodoluminescence (CL) spectra, kinetic decays, quantum yields (QY), and UV-visible diffuse reflectance spectra were employed to characterize the samples. The results show that hollow Lu(2)O(3):Ln spheres can be indexed to cubic Gd(2)O(3) phase with high purity. The as-prepared hollow Lu(2)O(3):Ln phosphors are confirmed to be uniform in shape and size with diameter of about 300 nm and shell thickness of approximate 20 nm. The possible formation mechanism of evolution from the carbon spheres to the amorphous precursor and to the final hollow Lu(2)O(3):Ln microspheres has been proposed. Upon ultraviolet (UV) and low-voltage electron beams excitation, the hollow Lu(2)O(3):Ln (Ln = Eu(3+), Tb(3+)) spheres exhibit bright red (Eu(3+), (5)D(0)-(7)F(2)) and green (Tb(3+), (5)D(4)-(7)F(5)) luminescence, which may find potential applications in the fields of color display and biomedicine.

  16. Fabrication, microstructure and luminescence properties of Cr3+ doped Lu3A15O12 red scintillator ceramics

    NASA Astrophysics Data System (ADS)

    Shi, Yun; Zhao, Yu; Liu, Qiang; Cao, Maoqing; Ma, Peng; Chen, Haohong; Liu, Qian; Li, Jiang

    2017-04-01

    Cr3+ doped Lu3A15O12 transparent ceramics were developed as a new red scintillator ceramics. These ceramics were fabricated by a solid state reaction method under vacuum sintering at temperature range of 1550 °C-1890 °C for 10 h. The doping effect of different Cr3+ concentration (0, 0.1, 0.3 and 0.5 at. %) and air annealing effect were investigated as well. The transparent ceramics (70% @1 mm in visible light range) with dense microstructure were obtained when sintered at 1890 °C for 10 h, the average grain size of 0.3 at.% Cr:LuAG was calculated to be 7 μm. Photo-luminescence spectra revealed that there are two typical excitation bands at around 450 nm and 600 nm which were ascribed to the d-d transitions of Cr3+. 0.3 at. % Cr:LuAG exhibited the optimum photoluminescence intensity and fast decay. Radio-luminescence under X-ray excitation indicated a characteristic Cr3+ emission peaking at 687 nm and 706 nm respectively. The Lu3+Al antisite defects related emission at around 300 nm was observed to decrease with the doping of Cr3+. The steady luminescence efficiency (XEL spectrum integral) is around 20 times of the commercial BGO crystals, more important, the broad and continuous red emission between 600 nm and 800 nm demonstrated Cr:LuAG ceramics a prospective application as new red scintillators.

  17. Charge ordering, ferroelectric, and magnetic domains in LuFe2O4 observed by scanning probe microscopy

    NASA Astrophysics Data System (ADS)

    Yang, I. K.; Kim, Jeehoon; Lee, S. H.; Cheong, S.-W.; Jeong, Y. H.

    2015-04-01

    LuFe2O4 is a multiferroic system which exhibits charge order, ferroelectricity, and ferrimagnetism simultaneously below ˜230 K. The ferroelectric/charge order domains of LuFe2O4 are imaged with both piezoresponse force microscopy (PFM) and electrostatic force microscopy (EFM), while the magnetic domains are characterized by magnetic force microscopy (MFM). Comparison of PFM and EFM results suggests that the proposed ferroelectricity in LuFe2O4 is not of usual displacive type but of electronic origin. Simultaneous characterization of ferroelectric/charge order and magnetic domains by EFM and MFM, respectively, on the same surface of LuFe2O4 reveals that both domains have irregular patterns of similar shape, but the length scales are quite different. The domain size is approximately 100 nm for the ferroelectric domains, while the magnetic domain size is much larger and gets as large as 1 μm. We also demonstrate that the origin of the formation of irregular domains in LuFe2O4 is not extrinsic but intrinsic.

  18. H4octapa-Trastuzumab: Versatile Acyclic Chelate System for 111In and 177Lu Imaging and Therapy

    PubMed Central

    Price, Eric W.; Zeglis, Brian M.; Cawthray, Jacqueline F.; Ramogida, Caterina F.; Ramos, Nicholas

    2013-01-01

    A bifunctional derivative of the versatile acyclic chelator H4octapa, p-SCNBn- H4octapa, has been synthesized for the first time. The chelator was conjugated to the HER2/neu-targeting antibody trastuzumab and labeled in high radiochemical purity and specific activity with the radioisotopes 111In and 177Lu. The in vivo behavior of the resulting radioimmunoconjugates was investigated in mice bearing ovarian cancer xenografts and compared to analogous radioimmunoconjugates employing the ubiquitous chelator DOTA. The H4octapa-trastuzumab conjugates displayed faster radiolabeling kinetics with more reproducible yields under milder conditions (15 min, RT, ~94–95%) than those based on DOTA-trastuzumab (60 min, 37 °C ~50–88%). Further, antibody integrity was better preserved in the 111In- and 177Lu-octapatrastuzumab constructs, with immunoreactive fractions of 0.99 for each compared to 0.93–0.95 for 111In- and 177Lu-DOTA-trastuzumab. These results translated to improved in vivo biodistribution profiles and SPECT imaging results for 111In- and 177Lu-octapa-trastuzumab compared to 111In- and 177Lu-DOTA-trastuzumab, with increased tumor uptake and higher tumor-to-tissue activity ratios. PMID:23901833

  19. [(177)Lu-PSMA therapy : Current evidence for use in the treatment of patients with metastatic prostate cancer].

    PubMed

    Boegemann, M; Schrader, A J; Rahbar, K

    2017-10-06

    Despite significant progress in the treatment of metastatic castration-resistant prostate cancer (mCRPC) in recent years (including agents targeting androgen receptor signaling, chemotherapy, and (223)Ra), most of these patients still succumb to prostate cancer. Recently, (177)lutetium prostate-specific membrane antigen radioligand therapy ((177)Lu-PSMA-RLT) has been increasingly used within compassionate use provisions in these patients in Germany and showed promising efficacy. Establishment of the current position of (177)Lu-PSMA-RLT in mCRPC in 2017. Presentation of the therapy landscape in mCRPC and the current challenges within treatment and survey of the available data on (177)Lu-PSMA-RLT after PubMed-based research. In several larger retrospective studies, (177)Lu-PSMA-RLT seems to be an encouraging new option with the potential to extend overall survival while displaying a favorable toxicity profile. Prospective trials are urgently needed to confirm these encouraging results found in retrospective analyses with (177)Lu-PSMA-RLT in the treatment of mCRPC.

  20. Hydroxide flux synthesis and crystal structure of the ordered palladate, LuNaPd{sub 6}O{sub 8}

    SciTech Connect

    Mugavero III, Samuel J.; Smith, Mark D.; Loye, Hans-Conrad zur . E-mail: ZurLoye@mail.chem.sc.edu

    2006-11-15

    We report the single crystal structure of LuNaPd{sub 6}O{sub 8} grown from a sodium hydroxide flux. The utilization of a hydroxide flux has led to the preparation of the first ordered substitution of a lanthanide metal and an alkali metal on the A-site in a platinum group oxide and the first palladate to contain both a lanthanide metal and an alkali metal. The 1:1 ordered substitution of Lu{sup 3+} and Na{sup +} in place of the commonly observed divalent cation leads to slabs of LuO{sub 8} and NaO{sub 8} cubes bridged together by PdO{sub 4} square planes. The compound crystallizes in the cubic space group Pm-3 (no. 200) with a=5.72500(10) A and is structurally related to other cubic palladium oxides. - Graphical abstract: Unit cell of the ordered palladate, LuNaPd{sub 6}O{sub 8} viewed along the z-direction. The Pd{sup 2+} cations (grey) reside in a square planar coordination environment and bridge together the LuO{sub 8} (blue) and NaO{sub 8} (yellow) cubes.

  1. Resolution, the key to unlocking granite petrogenesis using zircon U-Pb - Lu-Hf studies

    NASA Astrophysics Data System (ADS)

    Tapster, Simon; Horstwood, Matthew; Roberts, Nick M. W.; Deady, Eimear; Shail, Robin

    2017-04-01

    Coarse-scale understanding of crustal evolution and source contributions to igneous systems has been drastically enhanced by coupled zircon U-Pb and Lu-Hf data sets. These are now common place and potentially offer advantages over whole-rock analyses by resolving heterogeneous source components in the complex crystal cargos of single hand-samples. However, the application of coupled zircon U-Pb and Lu-Hf studies to address detailed petrogenetic questions faces a crisis of resolution - On the one hand, micro-beam analytical techniques have high spatial resolution, capable of interrogating crystals with complex growth histories. Yet, the >1-2% temporal resolution of these techniques places a fundamental limitation on their utility for developing petrogenetic models. This limitation in data interpretation arises from timescales of crystal recycling or changes in source evolution that are often shorter than the U-Pb analytical precision. Conversely, high-precision CA-ID-TIMS U-Pb analysis of single whole zircons and solution MC-ICP-MS Lu-Hf isotopes of column washes (Hf masses equating to ca. 10-50 ng) have much greater temporal resolution (<0.1%), yet lack the spatial resolution to deal with complex crystal growth. Analyses homogenize any heterogeneity within the zircon and convolute the petrogenetic model. A balance must be struck between spatial and temporal resolution to address petrogenetic issues. Here, we demonstrate that micro-sampling of complex xenocryst-rich zircon crystals (e.g. <40 µm zircon tips) from the granitic post-Variscan Cornubian Batholith (SW England), in tandem with low-common Pb blank CA-ID-TIMS U-Pb chemistry, permits the analysis of zircon volumes that approach those of LA-ICPMS analyses, whilst simultaneously retaining the majority of the temporal resolution associated with the CA-ID-TIMS U-Pb technique. The low volume of zircon within these analyses may only provide <5 ng Hf, and therefore gaining useful precision from Lu-Hf isotopes is

  2. Improving quantitative dosimetry in (177)Lu-DOTATATE SPECT by energy window-based scatter corrections.

    PubMed

    de Nijs, Robin; Lagerburg, Vera; Klausen, Thomas L; Holm, Søren

    2014-05-01

    Patient-specific dosimetry of lutetium-177 ((177)Lu)-DOTATATE treatment in neuroendocrine tumours is important, because uptake differs across patients. Single photon emission computer tomography (SPECT)-based dosimetry requires a conversion factor between the obtained counts and the activity, which depends on the collimator type, the utilized energy windows and the applied scatter correction techniques. In this study, energy window subtraction-based scatter correction methods are compared experimentally and quantitatively. (177)Lu SPECT images of a phantom with known activity concentration ratio between the uniform background and filled hollow spheres were acquired for three different collimators: low-energy high resolution (LEHR), low-energy general purpose (LEGP) and medium-energy general purpose (MEGP). Counts were collected in several energy windows, and scatter correction was performed by applying different methods such as effective scatter source estimation (ESSE), triple-energy and dual-energy window, double-photopeak window and downscatter correction. The intensity ratio between the spheres and the background was measured and corrected for the partial volume effect and used to compare the performance of the methods. Low-energy collimators combined with 208 keV energy windows give rise to artefacts. For the 113 keV energy window, large differences were observed in the ratios for the spheres. For MEGP collimators with the ESSE correction technique, the measured ratio was close to the real ratio, and the differences between spheres were small. For quantitative (177)Lu imaging MEGP collimators are advised. Both energy peaks can be utilized when the ESSE correction technique is applied. The difference between the calculated and the real ratio is less than 10% for both energy windows.

  3. Equiatomic intermetallic compounds REPtMg (RE = Y, Eu, Tb-Tm, Lu) - Structure and magnetism

    NASA Astrophysics Data System (ADS)

    Stein, Sebastian; Heletta, Lukas; Block, Theresa; Gerke, Birgit; Pöttgen, Rainer

    2017-05-01

    Eight new equiatomic REPtMg intermetallics with RE = Y, Eu, Tb-Tm, Lu were synthesized from the elements in sealed niobium ampoules (induction melting followed by different annealing sequences). All samples were characterized through X-ray powder patterns and the structures of YPtMg, EuPtMg, DyPtMg, HoPtMg and TmPtMg were refined from single crystal X-ray diffractometer data. The REPtMg phases crystallize with two different structure types. The representatives with RE = Y, Tb-Ho crystallize with the hexagonal ZrNiAl type, space group P 6 bar 2 m , while those with RE = Eu, Yb and Lu adopt the orthorhombic TiNiSi type, space group Pnma. ErPtMg and TmPtMg are dimorphic with a ZrNiAl type high and a TiNiSi type low-temperature modification. Temperature-dependent magnetic susceptibility measurements indicate Pauli paramagnetism for YPtMg and LuPtMg while EuPtMg, TbPtMg, DyPtMg and HoPtMg are Curie-Weiss paramagnets. Antiferromagnetic (TN = 12.6 K for EuPtMg) respectively ferromagnetic ordering (TC = 56.3 K for TbPtMg, 28.8 K for DyPtMg and 19.9 K for HoPtMg) occurs in the low-temperature regime. 151Eu Mössbauer spectra confirm divalent europium (δ = -8.03 mm s-1 at 78 K) in EuPtMg and show strong magnetic hyperfine field splitting below the Néel temperature.

  4. Repeated Lu-177-PSMA-617 radioligand therapy using treatment activities up to 9.3 GBq.

    PubMed

    Rathke, Hendrik; Giesel, Frederik L; Flechsig, Paul; Kopka, Klaus; Mier, Walter; Hohenfellner, Markus; Haberkorn, Uwe; Kratochwil, Clemens

    2017-08-10

    Current treatment protocols for (177)Lu-PSMA-617 therapies were cautiously derived from dosimetry data, but their practical appropriateness have not yet been proven clinically. We retrospectively report our clinical observations using four different treatment activities. Methods: Forty patients with advanced prostate cancer and positive uptake in PSMA-imaging were treated in fractions of 4 GBq / 80 nmol, 6 GBq / 120 nmol, 7.4 GBq / 150 nmol or 9.3 GBq / 150 nmol (177)Lu-activity / precursor-amount (n = 10, respectively) every 2 months. Safety lab was checked every 2 weeks, PSA-response every 4 weeks; other effects were assessed per anamnesis. Results: Initial PSA response presented no correlation to treatment activity. However, 2/10, 4/10, 4/10 and 7/10 patients with doses of 4, 6, 7.4 and 9.3 GBq were in partial remission 8 weeks after completing all 3 cycles; This would be in line with, but due to low patient numbers not proving, a positive dose-response-relationship. Acute hematological toxicity was also irrespective of treatment activity and no more than one grade-3/4 toxicity was observed in each group. Nevertheless, in contrast to the other groups the mean platelet count in the 9.3 GBq group chronically decreased over time. Conclusion: If patients with diffuse red marrow infiltration and extensive chemotherapeutical pretreatments are excluded, treatment activities up to three injections of 9.3 GBq (177)Lu-PSMA-617 every two months are well tolerable. Further dose escalation should be conducted with care as the MTD seems to be close. Copyright © 2017 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

  5. A study of response of a LuYAP:Ce array with innovative assembling for PET

    NASA Astrophysics Data System (ADS)

    Pani, Roberto; Cinti, Maria Nerina; Scafè, Raffaele; Bennati, Paolo; Lo Meo, Sergio; Preziosi, Enrico; Pellegrini, Rosanna; De Vincentis, Giuseppe; Sacco, Donatella; Fabbri, Andrea

    2015-09-01

    We propose the characterization of a first array of 10×10 Lutetium Yttrium Orthoaluminate Perovskite (LuYAP:Ce) crystals, 2 mm×2 mm×10 mm pixel size, with an innovative assembling designed to enhance light output, uniformity and detection efficiency. The innovation consists of the use of 0.015 mm thick dielectric coating as inter-pixel light-insulators, manufactured by Crytur (Czech Republic) intended to improve crystal insulation and then light collection. Respect to the traditional treatment with 0.2 mm of white epoxy, a thinner pixel gap enhances packing fraction up to 98% with a consequent improvement of detection efficiency. Spectroscopic characterization of the array was performed by a Hamamatsu R6231 photomultiplier tube. A pixel-by-pixel scanning with a collimated 99mTc radioisotope (140 keV photon energy) highlighted a deviation in pulse height close to 3.5% respect to the overall mean value. Meanwhile, in term of energy resolution a difference between the response of single pixel and the array of about 10% was measured. Results were also supported and validated by Monte Carlo simulations performed with GEANT4. Although the dielectric coating pixel insulator cannot overcome the inherent limitations of LuYAP crystal due to its self-absorption of light (still present), this study demonstrated that the new coating treatment allows better light collection (nearly close to the expected one) with in addition a very good uniformity between different pixels. These results confirm the high potentiality of this coating for any other crystal array suited for imaging application and new expectations for the use of LuYAP for PET systems.

  6. LuAlO{sub 3}: A high density, high speed scintillator for gamma detection

    SciTech Connect

    Moses, W.W.; Derenzo, S.E.; Fyodorov, A.; Korzhik, M.; Gektin, A.; Minkov, B.; Aslanov, V.

    1994-11-01

    We present measurements of the scintillation properties cerium doped lutetium aluminum perovskite, LuAlO{sub 3}:C, new dense ({rho}=8.34 g/cm{sup 3}) inorganic scintillator. This material has a 511 keV interaction length and photoelectric fraction 1.1 cm and 32% respectively, which are well suited to gamma ray detection. In powdered form with 0.5% cerium concentration, the scintillation light output is estimated to be 9,600 photons/MeV of deposited energy, the emission spectrum is a single peak centered at 390 nm, and the fluorescence lifetime is described by the sum of 3 exponential terms, with 60% of the light being emitted with a 11 ns decay time, 26% with a 28 ns decay time, and 13% with a 835 ns decay time. Single crystals contaminated with =10% lutetium aluminum garnet (Lu{sub 3}Al{sub 5}O{sub l2}) have significantly altered scintillation properties. The light output is 26,000 photons/MeV (3.2 times that of BGO), but the decay time increases significantly (1% of the light is emitted with a 10 ns decay time, 15% with a 245 ns decay time, and 85% with a 2010 ns decay time) and the emission spectrum is dominated by a peak centered at 315 nm with a secondary peak centered at 500 rum. The short decay lifetime, high density, and reasonable light output of LuAlO{sub 3}:C (the perovskite phase) suggest that it is useful for applications where high counting rates, good stopping power, good energy resolution, and fast timing are important. However, it is necessary to grow single crystals that are uncontaminated by the garnet phase to realize these properties.

  7. Improving quantitative dosimetry in 177Lu-DOTATATE SPECT by energy window-based scatter corrections

    PubMed Central

    Lagerburg, Vera; Klausen, Thomas L.; Holm, Søren

    2014-01-01

    Purpose Patient-specific dosimetry of lutetium-177 (177Lu)-DOTATATE treatment in neuroendocrine tumours is important, because uptake differs across patients. Single photon emission computer tomography (SPECT)-based dosimetry requires a conversion factor between the obtained counts and the activity, which depends on the collimator type, the utilized energy windows and the applied scatter correction techniques. In this study, energy window subtraction-based scatter correction methods are compared experimentally and quantitatively. Materials and methods 177Lu SPECT images of a phantom with known activity concentration ratio between the uniform background and filled hollow spheres were acquired for three different collimators: low-energy high resolution (LEHR), low-energy general purpose (LEGP) and medium-energy general purpose (MEGP). Counts were collected in several energy windows, and scatter correction was performed by applying different methods such as effective scatter source estimation (ESSE), triple-energy and dual-energy window, double-photopeak window and downscatter correction. The intensity ratio between the spheres and the background was measured and corrected for the partial volume effect and used to compare the performance of the methods. Results Low-energy collimators combined with 208 keV energy windows give rise to artefacts. For the 113 keV energy window, large differences were observed in the ratios for the spheres. For MEGP collimators with the ESSE correction technique, the measured ratio was close to the real ratio, and the differences between spheres were small. Conclusion For quantitative 177Lu imaging MEGP collimators are advised. Both energy peaks can be utilized when the ESSE correction technique is applied. The difference between the calculated and the real ratio is less than 10% for both energy windows. PMID:24525900

  8. High power, high repetition rate, few picosecond Nd:LuVO₄ oscillator with cavity dumping.

    PubMed

    Gao, Peng; Guo, Jie; Li, Jinfeng; Lin, Hua; Yu, Haohai; Zhang, Huaijin; Liang, Xiaoyan

    2015-12-28

    We investigate the potential use of Nd:LuVO4 in high average power, high repetition rate ultrafast lasers. Maximum mode-locked average power of 28 W is obtained at the repetition rate of 58 MHz. The shortest pulse duration is achieved at 4 ps without dispersion compensation. With a cavity dumping technique, the pulse energy is scaling up to 40.7 μJ at 300 kHz and 14.3 μJ at 1.5 MHz.

  9. Fiber-laser pumped actively Q-switched Er:LuYAG laser at 1648 nm

    NASA Astrophysics Data System (ADS)

    Yang, X. F.; Wang, Y.; Zhao, T.; Zhu, H. Y.; Shen, D. Y.

    2016-02-01

    We demonstrated an acousto-optic Q-switched 1648 nm Er:LuYAG laser resonantly pumped by a cladding-pumped Er,Yb fiber laser at 1532 nm. Stable Q-switching operation was obtained with the pulse repetition rate (PRR) varying from 200 Hz to 10 kHz. At PRR of 200 Hz, the laser yielded Q-switched pulses with 3.3 mJ pulse energy and 65 ns pulse duration, corresponding to a peak power of 50.7 kW for 10.4 W of incident pump power.

  10. German Multicenter Study Investigating 177Lu-PSMA-617 Radioligand Therapy in Advanced Prostate Cancer Patients.

    PubMed

    Rahbar, Kambiz; Ahmadzadehfar, Hojjat; Kratochwil, Clemens; Haberkorn, Uwe; Schäfers, Michael; Essler, Markus; Baum, Richard P; Kulkarni, Harshad R; Schmidt, Matthias; Drzezga, Alexander; Bartenstein, Peter; Pfestroff, Andreas; Luster, Markus; Lützen, Ulf; Marx, Marlies; Prasad, Vikas; Brenner, Winfried; Heinzel, Alexander; Mottaghy, Felix M; Ruf, Juri; Meyer, Philipp Tobias; Heuschkel, Martin; Eveslage, Maria; Bögemann, Martin; Fendler, Wolfgang Peter; Krause, Bernd Joachim

    2017-01-01

    (177)Lu-labeled PSMA-617 is a promising new therapeutic agent for radioligand therapy (RLT) of patients with metastatic castration-resistant prostate cancer (mCRPC). Initiated by the German Society of Nuclear Medicine, a retrospective multicenter data analysis was started in 2015 to evaluate efficacy and safety of (177)Lu-PSMA-617 in a large cohort of patients. One hundred forty-five patients (median age, 73 y; range, 43-88 y) with mCRPC were treated with (177)Lu-PSMA-617 in 12 therapy centers between February 2014 and July 2015 with 1-4 therapy cycles and an activity range of 2-8 GBq per cycle. Toxicity was categorized by the common toxicity criteria for adverse events (version 4.0) on the basis of serial blood tests and the attending physician's report. The primary endpoint for efficacy was biochemical response as defined by a prostate-specific antigen decline ≥ 50% from baseline to at least 2 wk after the start of RLT. A total of 248 therapy cycles were performed in 145 patients. Data for biochemical response in 99 patients as well as data for physician-reported and laboratory-based toxicity in 145 and 121 patients, respectively, were available. The median follow-up was 16 wk (range, 2-30 wk). Nineteen patients died during the observation period. Grade 3-4 hematotoxicity occurred in 18 patients: 10%, 4%, and 3% of the patients experienced anemia, thrombocytopenia, and leukopenia, respectively. Xerostomia occurred in 8%. The overall biochemical response rate was 45% after all therapy cycles, whereas 40% of patients already responded after a single cycle. Elevated alkaline phosphatase and the presence of visceral metastases were negative predictors and the total number of therapy cycles positive predictors of biochemical response. The present retrospective multicenter study of (177)Lu-PSMA-617 RLT demonstrates favorable safety and high efficacy exceeding those of other third-line systemic therapies in mCRPC patients. Future phase II/III studies are warranted to

  11. Multitasking the INS3D-LU code on the Cray Y-MP

    NASA Technical Reports Server (NTRS)

    Fatoohi, Rod; Yoon, Seokkwan

    1991-01-01

    This paper presents the results of multitasking the INS3D-LU code on eight processors. The code is a full Navier-Stokes solver for incompressible fluid in three dimensional generalized coordinates using a lower-upper symmetric-Gauss-Seidel implicit scheme. This code has been fully vectorized on oblique planes of sweep and parallelized using autotasking with some directives and minor modifications. The timing results for five grid sizes are presented and analyzed. The code has achieved a processing rate of over one Gflops.

  12. Luminescence properties of Lu2O3: Tb film prepared by Pechini sol-gel method

    NASA Astrophysics Data System (ADS)

    Shen, Siqing; Wang, Jian; Xu, Zhibin; Xie, Jianjun; Shi, Ying

    2011-02-01

    Uniform and crack free Tb3+ doped lutetium oxide (Lu2O3:Tb) films were prepared by Pechini sol-gel method combined with the spin-coating technique. The influence of the different substrate (monocrystalline silicon (111) and silica glass) and atmosphere (N2 and Air) on the luminescence properties of films was investigated. According to the emission spectra, we found that the luminous intensity was higher on silica glass substrate. Moreover, it was found that the luminous intensity calcined in N2 was higher almost twice as that calcined in air.

  13. Luminescence properties of Lu2O3: Tb film prepared by Pechini sol-gel method

    NASA Astrophysics Data System (ADS)

    Shen, Siqing; Wang, Jian; Xu, Zhibin; Xie, Jianjun; Shi, Ying

    2010-10-01

    Uniform and crack free Tb3+ doped lutetium oxide (Lu2O3:Tb) films were prepared by Pechini sol-gel method combined with the spin-coating technique. The influence of the different substrate (monocrystalline silicon (111) and silica glass) and atmosphere (N2 and Air) on the luminescence properties of films was investigated. According to the emission spectra, we found that the luminous intensity was higher on silica glass substrate. Moreover, it was found that the luminous intensity calcined in N2 was higher almost twice as that calcined in air.

  14. Topological band order, structural, electronic and optical properties of XPdBi (X = Lu, Sc) compounds

    NASA Astrophysics Data System (ADS)

    Narimani, M.; Nourbakhsh, Z.

    2016-05-01

    In this paper, the structural, electronic and optical properties of LuPdBi and ScPdBi compounds are investigated using the density functional theory by WIEN2K package within the generalized gradient approximation, local density approximation, Engel-Vosco generalized gradient approximations and modified Becke-Johnson potential approaches. The topological phases and band orders of these compounds are studied. The effect of pressure on band inversion strength, electron density of states and the linear coefficient of the electronic specific heat of these compounds is investigated. Furthermore, the effect of pressure on real and imaginary parts of dielectric function, absorption and reflectivity coefficients of these compounds is studied.

  15. Anomalous vortex state of superconducting LuNi2B2C

    NASA Astrophysics Data System (ADS)

    Price, A. N.; Miller, R. I.; Kiefl, R. F.; Chakhalian, J. A.; Dunsiger, S. R.; Morris, G. D.; Sonier, J. E.; Canfield, P. C.

    2002-06-01

    Muon spin rotation has been used to investigate the magnetic-field distribution in the vortex state of superconducting LuNi2B2C (Tc~16 K). Data for the magnetic field range 0.06Hc2<~H<~0.23Hc2 are fitted to a nonlocal London model. The temperature dependence of the vortex core radius shows a clear Kramer-Pesch effect due to depopulation of bound states within the cores. Also, the penetration depth and core radius vary substantially with applied magnetic field, suggesting the presence of anomalous field-induced quasiparticles and vortex-vortex interactions.

  16. Afterglow, low-temperature radioluminescence and thermoluminescence of Lu 2O 3:Eu ceramic scintillators

    NASA Astrophysics Data System (ADS)

    Kappers, L. A.; Bartram, R. H.; Hamilton, D. S.; Brecher, C.; Lempicki, A.

    2005-01-01

    Comparison of thermoluminescence (TL) and scintillation light outputs with continuous gamma-ray excitation reveals that the concentration of deep hole traps in ceramic Lu2O3:Eu, tentatively attributed to anion Frenkel defects, is enhanced by reversible radiation damage. Shallow electron and hole traps are tentatively attributed to surface states at grain boundaries. Electrons in shallow traps serve as non-radiative recombination centers. A model for anomalously persistent afterglow following pulsed X-ray excitation is based on a continuous distribution of hole traps inferred from TL following extended gamma-ray irradiation at -135 °C.

  17. Thermoelectric properties of ternary half-heuslar LuPdBi

    NASA Astrophysics Data System (ADS)

    Mukhopadhyay, A.; Mahana, S.; Chowki, S.; Topwal, D.; Mohapatra, N.

    2017-05-01

    We report the experimental study of low temperature thermoelectric properties of ternary half-Heuslar LuPdBi, synthesized by conventional arc melting. Resistivity measurements reveal the semi metallic nature of the conduction behavior, where holes are the major charge carriers as confirmed from positive value Seebeck coefficient in the entire temperature range 18-350 K. Thermal conductivity behavior indicates the dominance of phonon contribution and bipolaronic effects at low temperature regime with negligible electronic contribution. A considerably high power factor (˜ 100 μW/mK2) is obtained at room temperature.

  18. Structure and dynamics of the Lu2Si2O7 lattice: Ab initio calculation

    NASA Astrophysics Data System (ADS)

    Nazipov, D. V.; Nikiforov, A. E.

    2017-01-01

    The ab initio calculations have been carried out for the crystal structure and Raman spectrum of a single crystal of lutetium pyrosilicate Lu2Si2O7. The types of fundamental vibrations and their frequencies and intensities in the Raman spectrum for two polarizations of the crystal have been determined. The calculations have been performed within the framework of the density functional theory (DFT) using the hybrid functionals. The ions involved in the vibrations have been identified using the method of isotopic substitution. The results of the calculations are in good agreement with the experiment.

  19. Ho:Tm:Lu(3)Al(5)O(12) As An Infrared-Laser Material

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.; Morrison, Clyde A.; Filer, Elizabeth D.

    1995-01-01

    Material selected on basis of quantum-mechanical modeling of lasing properties. Ho:Tm:Lu(3)Al(5)O(12) features relatively low thermal occupation of lower laser level because this level higher than corresponding levels of most other available laser materials. In addition, it has reasonably large effective cross section for stimulated emission because of contribution of several transitions around central strong transition. Yet another desirable property is its calculated rate of upconversion is lower than those of other laser materials. Inasmuch as upconversion detracts from efficiency of laser, this lower rate of upconversion is highly desirable.

  20. Diode pumped passively Q-switched Nd:LuAG laser at 1442.6 nm

    NASA Astrophysics Data System (ADS)

    Guan, Chen; Liu, Zhaojun; Cong, Zhenhua; Liu, Yang; Xu, Xiaodong; Xu, Jun; Huang, Qingjie; Rao, Han; Chen, Xia; Zhang, Yanmin; Wu, Qianwen; Bai, Fen; Zhang, Sasa

    2017-02-01

    A diode-end-pumped passively Q-switched Nd:LuAG laser at 1442.6 nm was demonstrated with a V3+:YAG crystal as the saturable absorber. Under continuous-wave (CW) operation, the maximum output power of 1.83 W was obtained with an absorbed pumping power of 11.1 W. The corresponding optical-to-optical conversion efficiency was 16.5%. Under Q-switched operation, the maximum average output power of 424 mW was obtained at the same pumping power. The pulse duration and pulse repetition rate were 72 ns and 17.4 kHz, respectively.

  1. Direct band gaps in multiferroic h-LuFeO{sub 3}

    SciTech Connect

    Holinsworth, B. S.; Mazumdar, D.; Musfeldt, J. L.; Brooks, C. M.; Mundy, J. A.; Das, H.; Fennie, C. J.; Cherian, J. G.; McGill, S. A.; Schlom, D. G.

    2015-02-23

    We measured the optical properties of epitaxial thin films of the metastable hexagonal polymorph of LuFeO{sub 3} by absorption spectroscopy, magnetic circular dichroism, and photoconductivity. Comparison with complementary electronic structure calculations reveals a 1.1 eV direct gap involving hybridized Fe 3d{sub z{sup 2}}+O 2p{sub z}→Fe d excitations at the Γ and A points, with a higher energy direct gap at 2.0 eV. Both charge gaps nicely overlap the solar spectrum.

  2. Observation of the 1S0 to 3D1 clock transition in 175Lu+

    NASA Astrophysics Data System (ADS)

    Arnold, K. J.; Kaewuam, R.; Roy, A.; Paez, E.; Wang, S.; Barrett, M. D.

    2016-11-01

    We report direct laser spectroscopy of the 1S0 to 3D1 highly-forbidden M1 clock transition in 175Lu+ . Clock operation is demonstrated on three pairs of Zeeman transitions, one pair from each hyperfine manifold of the 3D1 term. We measure the hyperfine intervals of the 3D1 to 10 ppb uncertainty and infer the optical frequency averaged over the three hyperfine transitions to be 353.639 915 952 2 (6 ) THz. The lifetime of the 3D1 state is inferred to be 174-32+23 hours from the M1 coupling strength.

  3. Performance evaluation and enhancement of SuperLU{_}DIST 2.0

    SciTech Connect

    Li, Xiaoye S.; Wang, Yu

    2003-08-28

    We present the runtime comparison of the two versions of Super LU{_}DIST, using up to 128 processors of the IBM SP at NERSC. One version provides the global input interface, and another provides the distributed input interface. The comparison includes the total runtime of the solver with both 32-bit and 64-bit addressing modes, the time breakdown for different phases of the solver. We also present an in-depth comparison off our sparse matrix-vector multiplication methods in the context of iterative refinement. Finally, we describe our Fortran 90 interface that enhances the usability of the software.

  4. Multiferroic Properties of o-LuMnO3 Controlled by b-Axis Strain

    NASA Astrophysics Data System (ADS)

    Windsor, Y. W.; Huang, S. W.; Hu, Y.; Rettig, L.; Alberca, A.; Shimamoto, K.; Scagnoli, V.; Lippert, T.; Schneider, C. W.; Staub, U.

    2014-10-01

    Strain is a leading candidate for controlling magnetoelectric coupling in multiferroics. Here, we use x-ray diffraction to study the coupling between magnetic order and structural distortion in epitaxial films of the orthorhombic (o-) perovskite LuMnO3. An antiferromagnetic spin canting in the E-type magnetic structure is shown to be related to the ferroelectrically induced structural distortion and to a change in the magnetic propagation vector. By comparing films of different orientations and thicknesses, these quantities are found to be controlled by b-axis strain. It is shown that compressive strain destabilizes the commensurate E-type structure and reduces its accompanying ferroelectric distortion.

  5. Strain-induced ferromagnetism in antiferromagnetic LuMnO3 thin films.

    PubMed

    White, J S; Bator, M; Hu, Y; Luetkens, H; Stahn, J; Capelli, S; Das, S; Döbeli, M; Lippert, Th; Malik, V K; Martynczuk, J; Wokaun, A; Kenzelmann, M; Niedermayer, Ch; Schneider, C W

    2013-07-19

    Single phase and strained LuMnO(3) thin films are discovered to display coexisting ferromagnetic and antiferromagnetic orders. A large moment ferromagnetism (≈1μ(B)), which is absent in bulk samples, is shown to display a magnetic moment distribution that is peaked at the highly strained substrate-film interface. We further show that the strain-induced ferromagnetism and the antiferromagnetic order are coupled via an exchange field, therefore demonstrating strained rare-earth manganite thin films as promising candidate systems for new multifunctional devices.

  6. Intertwining of Frustration with Magneto-Elastic Coupling in the Multiferroic LuMnO3

    NASA Astrophysics Data System (ADS)

    Yano, Shin-ichiro; Louca, Despina; Chi, Songxue; Matsuda, Masaaki; Qiu, Yiming; Copley, John R. D.; Cheong, Sang-Wook

    2014-02-01

    Residual magnetic frustration in the multiferroic LuMnO3 may be key towards understanding magneto-elastic coupling in hexagonal manganites. Critical magnetic scattering present well above the magnetic ordering temperature TN persists below, as observed by inelastic neutron scattering. The magnetic fluctuations are confined in two dimensions implied by the characteristic wavevector dependence of the magnetic structure factor that changes from symmetric to asymmetric across TN. The low dimensionality of the magnetic structure is also evident in the temperature dependence of the commensurate antiferromagnetic intensity which follows a mean field exponent of β ˜ 0.2.

  7. Coherent acoustic phonons in hexagonal manganite LuMnO3

    NASA Astrophysics Data System (ADS)

    Lim, D.; Averitt, R. D.; Demsar, J.; Taylor, A. J.; Hur, N.; Cheong, S. W.

    2003-12-01

    We have observed coherent acoustic phonons in the hexagonal manganite LuMnO3 using two-color femtosecond optical pump-probe spectroscopy. The dependence of the oscillatory component of the photoinduced reflectivity on the probe wavelength and incident angle is consistent with a propagating strain pulse. Moreover, the frequency, dephasing, and phase of the oscillation are found to be temperature dependent. In particular, a large phase shift occurs in the vicinity of the Néel temperature (TN), which we relate to the temperature-dependent on-site Mn d-d transition that is coupled to antiferromagnetic ordering, as recently observed in optical conductivity measurements.

  8. Magnetic domains in the ferromagnetic and ferroelectric mixture of (La, Lu, Sr)MnO3

    NASA Astrophysics Data System (ADS)

    de Lozanne, Alex; Hur, N.

    2005-03-01

    Single crystals of (La5/8Sr3/8MnO3)x(LuMnO3)1-x (LSMO)(LMO) synthesized by the floating-zone method were studied by Magnetic Force Microscopy (MFM). Samples were mechanically cut and polished with the surface normal to the growth direction. Polarized optical microscopy shows that LSMO and LMO are separated in a stripe-like pattern due to the chemical immiscibility.ootnotetextS. Park, et al., PRL 92, 167206 (2004) MFM images show magnetic domains (˜1μm) in the LSMO stripes and no magnetic signal in the LMO phase.

  9. Multiferroic properties of o-LuMnO3 controlled by b-axis strain.

    PubMed

    Windsor, Y W; Huang, S W; Hu, Y; Rettig, L; Alberca, A; Shimamoto, K; Scagnoli, V; Lippert, T; Schneider, C W; Staub, U

    2014-10-17

    Strain is a leading candidate for controlling magnetoelectric coupling in multiferroics. Here, we use x-ray diffraction to study the coupling between magnetic order and structural distortion in epitaxial films of the orthorhombic (o-) perovskite LuMnO(3). An antiferromagnetic spin canting in the E-type magnetic structure is shown to be related to the ferroelectrically induced structural distortion and to a change in the magnetic propagation vector. By comparing films of different orientations and thicknesses, these quantities are found to be controlled by b-axis strain. It is shown that compressive strain destabilizes the commensurate E-type structure and reduces its accompanying ferroelectric distortion.

  10. Strain-Induced Ferromagnetism in Antiferromagnetic LuMnO3 Thin Films

    NASA Astrophysics Data System (ADS)

    White, J. S.; Bator, M.; Hu, Y.; Luetkens, H.; Stahn, J.; Capelli, S.; Das, S.; Döbeli, M.; Lippert, Th.; Malik, V. K.; Martynczuk, J.; Wokaun, A.; Kenzelmann, M.; Niedermayer, Ch.; Schneider, C. W.

    2013-07-01

    Single phase and strained LuMnO3 thin films are discovered to display coexisting ferromagnetic and antiferromagnetic orders. A large moment ferromagnetism (≈1μB), which is absent in bulk samples, is shown to display a magnetic moment distribution that is peaked at the highly strained substrate-film interface. We further show that the strain-induced ferromagnetism and the antiferromagnetic order are coupled via an exchange field, therefore demonstrating strained rare-earth manganite thin films as promising candidate systems for new multifunctional devices.

  11. Lu-Hf and Sm-Nd Isotopic Studies of Shergottites and Nakhlites: Implications for Martian Mantle Sources

    NASA Technical Reports Server (NTRS)

    Debaille, V.; Yin, Q.-Z.; Brandon, A. D.; Jacobsen, B.; Treiman, A. H.

    2007-01-01

    We present a new Lu-Hf and Sm-Nd isotope systematics study of four enriched shergottites (Zagami, Shergotty, NWA856 and Los Angeles), and three nakhlites (Nakhla, MIL03346 and Yamato 000593) in order to further understand processes occurring during the early differentiation of Mars and the crystallization of its magma ocean. Two fractions of the terrestrial petrological analogue of nakhlites, the Archaean Theo's flow (Ontario, Canada) were also measured. The coupling of Nd and Hf isotopes provide direct insights on the mineralogy of the melt sources. In contrast to Sm/Nd, Lu/Hf ratios can be very large in minerals such as garnet. Selective partial melting of garnet bearing mantle sources can therefore lead to characteristic Lu/Hf signatures that can be recognized with Hf-176/Hf-177Hf ratios.

  12. Lu1-xI3:Cex--A Scintillator for gamma ray spectroscopy and time-of-flight PET

    DOEpatents

    Shah, Kanai S [Newton, MA

    2009-03-17

    The present invention concerns very fast scintillator materials comprising lutetium iodide doped with Cerium Lu.sub.1-xI.sub.3:Ce.sub.x; LuI.sub.3:Ce). The LuI.sub.3 scintillator material has surprisingly good characteristics including high light output, high gamma ray stopping efficiency, fast response, low cost, good proportionality, and minimal afterglow that the material is useful for gamma ray spectroscopy, medical imaging, nuclear and high energy physics research, diffraction, non-destructive testing, nuclear treaty verification and safeguards, and geological exploration. The timing resolution of the scintillators of the present invention provide compositions capable of resolving the position of an annihilation event within a portion of a human body cross-section.

  13. Reconstruction of the polar interface between hexagonal LuFeO3 and intergrown Fe3O4 nanolayers

    PubMed Central

    Akbashev, A. R.; Roddatis, V. V.; Vasiliev, A. L.; Lopatin, S.; Amelichev, V. A.; Kaul, A. R.

    2012-01-01

    We report the observation of an unusual phase assembly behavior during the growth of hexagonal LuFeO3 thin films which resulted in the formation of epitaxial Fe3O4 nanolayers. The magnetite layers were up to 5 nm thick and grew under the conditions at which Fe2O3 is thermodynamically stable. These Fe3O4 nanolayers act as buffer layers promoting a highly epitaxial growth of the hexagonal LuFeO3 thin film up to 150 nm thick. Using scanning transmission electron microscopy, we show that the interface between (001) LuFeO3 and (111) Fe3O4 can be reconstructed in two ways depending on the sequence in which these compounds grow on each other. We suggest the polarity of the interface is the reason behind the observed interface reconstruction and epitaxial stabilization of magnetite. PMID:22993697

  14. Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

    SciTech Connect

    Frost, Sophia; Frayo, Shani; Miller, Brian W.; Orozco, Johnnie J.; Booth, Garrett C.; Hylarides, Mark; Lin, Yukang; Green, Damian J.; Gopal, Ajay K.; Pagel, John M.; Back, Tom; Fisher, Darrell R.; Press, Oliver W.

    2015-03-01

    Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice.

  15. Development and biological studies of ¹⁷⁷Lu-DOTA-rituximab for the treatment of Non-Hodgkin's lymphoma.

    PubMed

    Massicano, Adriana V F; Pujatti, Priscilla B; Alcarde, Lais F; Suzuki, Miriam F; Spencer, Patrick J; Araújo, Elaine B

    2016-01-01

    The optimization of DOTA-NHS-ester conjugation to Rituximab using different Ab:DOTA molar ratios (1:10, 1:20, 1:50 and 1:100) was studied. High radiochemical yield, in vitro stability and immunoreactive fraction were obtained for the Rituximab conjugated at 1:50 molar ratio, resulting in the incorporation of an average number of 4.9 ± 1.1 DOTA per Rituximab molecule. Labeling with 177Lu was performed in high specific activity with great in vitro stability. Biodistribution in healthy and xenographed mice showed tumor uptake and high in vivo stability as evidenced by low uptake in bone. The properties of 177Lu-DOTA-Rituximab prepared from DOTA-NHS-ester suggest the potential for the application of the 177Lu-labeled antibody in preliminary clinical studies.

  16. Luminescence of Bi 3+ in the metaphosphates LnP 3O 9 ( Ln = Sc, Lu, Y, Gd, La)

    NASA Astrophysics Data System (ADS)

    Oomen, E. W. J. L.; Blasse, G.

    1988-07-01

    The luminescence of the Bi 3+ ion (6 s2) is studied in the metaphosphates LnP 3O 9 ( Ln = Sc, Lu, Y, Gd, La). For Ln = Sc, Lu, Y, Gd the metaphosphates have a monoclinic structure with four slightly different sites for the trivalent cations. For Ln = Sc, Lu, Y the Stokes shift of the Bi 3+ luminescence increased with increasing radius of the host lattice cation. Concentration quenching of the Bi 3+ luminescence is observed. In the case of GdP 3O 9-Bi 3+ the excitation energy is transferred to the Gd 3+ ions. LaP 3O 9 adopts an orthorhombic structure with only one site available for the trivalent cations. The different coordination of the Bi 3+ ion leads to a large increase of the Stokes shift of the Bi 3+ luminescence.

  17. New microarchitectures of (Er,Yb):Lu2O3 nanocrystals embedded in PMMA: synthesis, structural characterization, and luminescent properties

    PubMed Central

    2013-01-01

    We report the formation of two-dimensional disordered arrays of poly(methyl)methacrylate (PMMA) microcolumns with embedded single size distribution of Lu0.990Er0.520Yb0.490 nanocrystals, (Er,Yb):Lu2O3, using a disordered porous silicon template. The cubic (Er,Yb):Lu2O3 nanocrystals, which crystallize into the cubic system with Ia3¯ space group, were synthesized using the modified Pechini method. Electronic microscopic techniques were used to study the distribution of the nanocrystals in the PMMA columns. Cathodoluminescence was used to observe the visible luminescence of the particles. Red emission attributed to 4 F9/2 → 4I15/2 erbium transition is predominant in these new composites. PMID:24034270

  18. Lu{sub 2}O{sub 3}:Eu{sup 3+} glass ceramic films: Synthesis, structural and spectroscopic studies

    SciTech Connect

    Carrera Jota, M.L.; García Murillo, A.; Morales Ramírez, A. de J.; Rosa Cruz, E. de la; Kassiba, Abdelhadi

    2014-03-01

    Graphical abstract: - Highlights: • Lu{sub 2}O{sub 3}:Eu{sup 3+}@SiO{sub 2} films were synthesized by sol–gel and by dip-coating technique. • Effects of incorporating PVP on structural properties were studied. • Effects of incorporating silica (SiO{sub 2}) luminescence characteristics were analyzed. • X-ray diffraction results showed that Lu{sub 2}O{sub 3}:Eu{sup 3+}@SiO{sub 2} crystallizes at 700 °C. • The 611 nm emission for the Lu:Si = 8:1 system presented an improvement. - Abstract: For the first time, transparent and crack free europium-doped lutetia silica sol–gel films were synthesized using the dip-coating technique on silica quartz substrates. In this study, we examined the effects of incorporating polyvinylpyrrolidone (PVP) and silica (SiO{sub 2}) into different precursor solutions for different Lu–Si molar ratios: 4:1, 6:1, 8:1 and 10:1. Different systems, such as Lu{sub 2}O{sub 3}:Eu{sup 3+}@SiO{sub 2} (using the above Lu:Si molar ratios), were synthesized by sol–gel and by dip-coating technique, employing acetylacetonate lutetium and tetraethylorthosilicate as Lu and Si precursors, in order to produce Lu{sub 2}O{sub 3}:Eu{sup 3+} (5 mol%)@SiO{sub 2} glass–ceramic films. The film microstructure was studied by microRaman spectroscopy (MRS) and X-ray diffraction (XRD) for different Lu:Si molar ratios on films annealed at 700 °C. X-ray diffraction results showed that the lutetium oxide cubic phase crystallizes in the silica matrix at 700 °C, and the crystallite size of Lu{sub 2}O{sub 3}:Eu{sup 3+}@SiO{sub 2} films varies from 5 nm to 17 nm according to the respective Lu:Si molar ratios. Opto-geometrical parameters determined by m-lines spectroscopy using a 632.5 nm He–Ne laser showed that the Eu{sup 3+} doped films heat-treated at 700 °C presented a thickness and density of 1.7 μm (8.8 g cm{sup −3}), 970 nm (9.2 g cm{sup −3}), 1 μm (9.3 g cm{sup −3}) and 1.3 μm (9.25 g cm{sup −3}) for the Lu:Si = 4:1, 6:1, 8:1 and 10

  19. Evaluation of (177)Lu-CHX-A''-DTPA-Bevacizumab as a radioimmunotherapy agent targeting VEGF expressing cancers.

    PubMed

    Kameswaran, Mythili; Pandey, Usha; Gamre, Naresh; Vimalnath, K V; Sarma, Haladhar Dev; Dash, Ashutosh

    2016-08-01

    This study aimed at the preparation and evaluation of (177)Lu-CHX-A''-DTPA-Bevacizumab for targeting VEGF over-expressing cancers. Bevacizumab conjugated to p-NCS-Bn-CHX-A''-DTPA was radiolabeled with (177)Lu. The radioimmunoconjugate characterized by SE-HPLC exhibited radiochemical purity of 98.0±0.6%. In vitro stability was retained upto 4 days at 37°C. In vitro cell binding studies showed good uptake by VEGF expressing U937 tumor cells. Biodistribution studies in melanoma model showed significant uptake and retention of (177)Lu-CHX-A''-DTPA-Bevacizumab in tumor with reduction in uptake in presence of cold Bevacizumab confirming its specificity to VEGF. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Investigation of magnetic structure evolution in the substitutional solid solution ScxLu(1-x)MnO3

    NASA Astrophysics Data System (ADS)

    Bieringer, M.; Greedan, J. E.; Wills, A. S.

    The hexagonal series AMnO3 (A = Lu, Sc) (space group: P63cm) is an excellent model system for the investigation of magnetic frustration as the magnetic sublattice is made up of edge sharing triangles with nearest neighbour antiferromagnetic exchange. At low temperatures the Mn3+ moments form a 120° long range ordered state. In LuMnO3 (TN=91 K) the magnetic moments are in the ab-plane and perpendicular to the hexagonal axis, whereas ScMnO3 (TN=130 K) undergoes an in-plane spin-reorientation transition below T=70 K. Powder neutron diffraction experiments for the substitutional solid solution ScxLu(1-x)MnO3 (0.0<=x<=1.0) show the evolution of the spin-reorientation as a function of x.

  1. Orthogonally polarized dual-wavelength Nd:LuVO4 laser at 1086 nm and 1089 nm.

    PubMed

    Huang, Y P; Cho, C Y; Huang, Y J; Chen, Y F

    2012-02-27

    A comparison between the fluorescence spectra of the Nd-doped vanadate crystals (Nd:YVO4, Nd:GdVO4, Nd:LuVO4) for the 4F3/2 → 4I11/2 transition is studied. We numerically analyze the condition of gain-to-loss balance via an uncoated intracavity etalon to achieve the dual-wavelength operation. We further experimentally demonstrate the orthogonally polarized dual-wavelength laser with a single Nd:LuVO4 crystal. The simultaneous dual-wavelength Nd:LuVO4 laser at 1085.7 nm in σ polarization and 1088.5 nm in π polarization is realized. At an incident pump power of 12 W, the average output power obtained at 1085.7 nm and 1088.5 nm is 0.4 W and 1.7 W, respectively.

  2. Archean Lithosphere Beneath Arctic Canada: Lu-Hf Isotope Systematics for Kimberlite-Hosted Garnet-Peridotites From Somerset Island

    NASA Astrophysics Data System (ADS)

    Schmidberger, S. S.; Simonetti, A.; Francis, D.; Gariepy, C.

    2001-05-01

    Knowledge of the age of lithospheric mantle underlying the continents provides valuable constraints for the timing of formation and stabilization of Archean cratons. This study reports Lu-Hf isotopic data for garnet-peridotites, and their constituent garnets, from the Nikos kimberlite (100 Ma) on Somerset Island in the Canadian Arctic obtained using a Micromass IsoProbe multicollector inductively coupled plasma mass spectrometer (MC-ICP-MS) at GEOTOP-UQAM. The low temperature peridotites (<1100 C; 80-150 km) exhibit a significant range in 176Lu/177Hf ratios (0.03-0.05) and are characterized by radiogenic 176Hf/177Hf(0.1Ga) isotopic compositions (0.28294-0.28419) corresponding to \\epsilonHf(0.1Ga) values of +8 to +52. In contrast, 176Lu/177Hf ratios (0.004-0.04) are lower for the high temperature peridotites (>1100 C; 160-190 km) and their 176Hf/177Hf(0.1Ga) isotopic compositions (0.28265-0.28333; \\epsilonHf(0.1Ga)=-2 to +22) are less radiogenic than those of the shallow xenoliths. A Lu-Hf isochron for six peridotites yields a mid Archean age of 3.4\\pm0.3 Ga and an initial 176Hf/177Hf ratio of 0.28101\\pm24. The remaining peridotites (n=9), in contrast, are characterized by extremely high (+35) initial \\epsilonHf(3.4Ga) values, which correlate negatively with their 176Lu/177Hf ratios, suggesting addition of Hf as a result of metasomatic interaction with the host kimberlite. The garnets from the low temperature (3.4 Ga old) peridotites are characterized by high 176Lu/177Hf ratios and define an errorchron age of 1.4\\pm0.2 Ga, which may reflect re-equilibration of Hf during kimberlite magmatism.

  3. Preparation and Evaluation of (177)Lu-Labeled Gemcitabine: An Effort Toward Developing Radiolabeled Chemotherapeutics for Targeted Therapy Applications.

    PubMed

    Ghosh, Subhajit; Das, Tapas; Sarma, Haladhar D; Dash, Ashutosh

    2017-09-06

    Gemcitabine, a nucleoside analogue, is used as a chemotherapeutic drug for the treatment of a wide variety of cancers. Therefore, radiolabeled gemcitabine may have potential as a radiotherapeutic agent for the treatment of various types of cancers. In the present work, an attempt has been made to radiolabel gemcitabine with (177)Lu and study the preliminary biological behavior of (177)Lu-labeled gemcitabine in tumor-bearing animal model. Gemcitabine was coupled with p-NCS-benzyl-DOTA, a bifunctional chelating agent, to facilitate radiolabeling with (177)Lu. The p-NCS-benzyl-DOTA-gemcitabine conjugate was radiolabeled with (177)Lu, produced in-house and characterized by high-performance liquid chromatography. Tumor targeting potential of the radiolabeled agent was determined by biodistribution studies in Swiss mice bearing fibrosarcoma tumors. (177)Lu-gemcitabine was prepared with a radiochemical purity of 95.7% ± 0.3% under the optimized reaction conditions. The radiolabeled agent showed adequate in vitro stability in normal saline as well as in human blood serum. Preliminary biological studies revealed rapid and significant accumulation of the radiotracer in the tumorous lesions along with fast clearance of activity from blood and other vital organs/tissue. Although tumor uptake gradually reduced with time, tumor to blood and tumor to muscle ratios were improved due to the comparatively faster clearance of activity from the nontarget organs/tissue. The present study demonstrates the preliminary potential of (177)Lu-gemcitabine for targeted radiotherapy. However, further studies are warranted to assess its potential for radiotherapeutic applications.

  4. Synthesis and comparative biological evaluation of bifunctional ligands for radiotherapy applications of (90)Y and (177)Lu.

    PubMed

    Chong, Hyun-Soon; Sun, Xiang; Chen, Yunwei; Sin, Inseok; Kang, Chi Soo; Lewis, Michael R; Liu, Dijie; Ruthengael, Varyanna C; Zhong, Yongliang; Wu, Ningjie; Song, Hyun A

    2015-03-01

    Zevalin® is an antibody-drug conjugate radiolabeled with a cytotoxic radioisotope ((90)Y) that was approved for radioimmunotherapy (RIT) of B-cell non-Hodgkin's lymphoma. A bifunctional ligand that displays favorable complexation kinetics and in vivo stability is required for effective RIT. New bifunctional ligands 3p-C-DE4TA and 3p-C-NE3TA for potential use in RIT were efficiently prepared by the synthetic route based on regiospecific ring opening of aziridinium ions with prealkylated triaza- or tetraaza-backboned macrocycles. The new bifunctional ligands 3p-C-DE4TA and 3p-C-NE3TA along with the known bimodal ligands 3p-C-NETA and 3p-C-DEPA were comparatively evaluated for potential use in targeted radiotherapy using β-emitting radionuclides (90)Y and (177)Lu. The bifunctional ligands were evaluated for radiolabeling kinetics with (90)Y and (177)Lu, and the corresponding (90)Y or (177)Lu-radiolabeled complexes were studied for in vitro stability in human serum and in vivo biodistribution in mice. The results of the comparative complexation kinetic and stability studies indicate that size of macrocyclic cavity, ligand denticity, and bimodality of donor groups have a substantial impact on complexation of the bifunctional ligands with the radiolanthanides. The new promising bifunctional chelates in the DE4TA and NE3TA series were rapid in binding (90)Y and (177)Lu, and the corresponding (90)Y- and (177)Lu-radiolabeled complexes remained inert in human serum or in mice. The in vitro and in vivo data show that 3p-C-DE4TA and 3p-C-NE3TA are promising bifunctional ligands for targeted radiotherapy applications of (90)Y and (177)Lu. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Synthesis and Comparative Biological Evalution of Bifunctional Ligands for Radiotherapy Applications of 90Y and 177Lu

    PubMed Central

    Chong, Hyun-Soon; Sun, Xiang; Chen, Yunwei; Sin, Inseok; Kang, Chi Soo; Lewis, Michael R.; Liu, Dijie; Ruthengael, Varyanna C.; Zhong, Yongliang; Wu, Ningjie; Song, Hyun A

    2015-01-01

    Zevalin® is an antibody-drug conjugate radiolabeled with a cytotoxic radioisotope (90Y) that was approved for radioimmunotherapy (RIT) of B-cell non-Hodgkin’s lymphoma. A bifunctional ligand that displays favorable complexation kinetics and in vivo stability is required for effective RIT. New bifunctional ligands 3p-C-DE4TA and 3p-C-NE3TA for potential use in RIT were efficiently prepared by the synthetic route based on regiospecific ring opening of aziridinium ions with prealkylated triaza- or tetraaza-backboned macrocycles. The new bifunctional ligands 3p-C-DE4TA and 3p-C-NE3TA along with the known bimodal ligands 3p-C-NETA and 3p-C-DEPA were comparatively evaluated for potential use in targeted radiotherapy using β-emitting radionuclides 90Y and 177Lu. The bifunctional ligands were evaluated for radiolabeling kinetics with 90Y and 177Lu, and the corresponding 90Y or 177Lu-radiolabeled complexes were studied for in vitro stability in human serum and in vivo biodistribution in mice. The results of the comparative complexation kinetic and stability studies indicate that size of macrocyclic cavity, ligand denticity, and bimodality of donor groups have a substantial impact on complexation of the bifunctional ligands with the radiolanthanides. The new promising bifunctional chelates in the DE4TA and NE3TA series were rapid in binding 90Y and 177Lu, and the corresponding 90Y- and 177Lu-radiolabeled complexes remained inert in human serum or in mice. The in vitro and in vivo data show that 3p-C-DE4TA and 3p-C-NE3TA are promising bifunctional ligands for targeted radiotherapy applications of 90Y and 177Lu. PMID:25648683

  6. REE and Lu-Hf systematics of zircons from rapakivi granites and associated rocks of supercontinent Nuna (Columbia)

    NASA Astrophysics Data System (ADS)

    Ronkin, Yu. L.; Gerdes, A.; Maslov, A. V.

    2015-03-01

    The last of the rifting events at 1.37-1.45 Ga that is considered to have led to the final breakup of Nuna was recorded in most of its building blocks (Laurentia, Baltica, and Siberian craton). At the type locality for the Riphean on the western slope of the South Urals, this event was recognized as the Mashak igneous event (˜1380 Ma) and can be classified as a LIP based on the volumes of magma generated (total igneous volumes >0.05 × 106 km3). The emplacement of large volumes of A-type granitic plutons in Laurentia and northwestern Baltica (in the present coordinates) was almost synchronous with this event. In the South Urals, within the Bashkirian meganticlinorium, the processes of granite generation and emplacement during this time took place on a much smaller scale. Anorogenic granites of this region are represented by rapakivi granites of the Berdyaush massif. The first REE and Lu-Hf isotope data for zircons from rapakivi granites and associated rocks of the Berdyaush massif reveal almost identical Lu-Hf isotope ages (˜1383 Ma) of rapakivi granites, quartz syenitic diorites, and nepheline syenites. It was shown that these rocks, which were emplaced into the heterogeneous Proterozoic crust between the Early and Middle Riphean, have the Hf isotopic compositions and Lu-Hf model ages reflecting the contribution from crustal sources with ages of 2013-2219 Ma, whereas the associated gabbros indicate derivation from a source with the Lu-Hf ages of 1658 ± 1685 Ma and moderately depleted ɛHf(1383) of (4.1 ± 0.7-4.9 ± 0.6). The REE characteristics (ΣREE, Eu/Eu*, Ce/Ce*, Pr/Pr*, La/Lu) and Lu-Hf isotope systematics of zircons can be used to constrain the history and genetic evolution of supercontinents, e.g., supercontinent Nuna (Columbia) in particular.

  7. A Randomized Phase 2 Trial of 177Lu Radiolabeled Anti-PSMA Monoclonal Antibody J591 in Patients with High-Risk Castrate, Biochemically Relapsed Prostate Cancer

    DTIC Science & Technology

    2014-09-01

    hypothesis is that the addition of 177Lu-J591 to ketoconazole will improve time to radiographically apparent metastases in men with biochemically...primary endpoint will be to compare the percentage of men with metastases at 18 months receiving ketoconazole plus 177Lu-J591 vs ketoconazole plus trace

  8. A Randomized Phase 2 Trial of 177Lu Radiolabeled Anti-PSMA Monoclonal Antibody J591 in Patients With High-Risk Castrate Biochemically Relapsed Prostate Cancer

    DTIC Science & Technology

    2015-09-01

    modalities). The hypothesis is that the addition of 177Lu-J591 to ketoconazole will improve time to radiographically apparent metastases in men with...The primary endpoint will be to compare the percentage of men with metastases at 18 months receiving ketoconazole plus 177Lu-J591 vs ketoconazole plus

  9. A systematic study on the utility of CHX-A''-DTPA-NCS and NOTA-NCS as bifunctional chelators for (177)Lu radiopharmaceuticals.

    PubMed

    Pandey, Usha; Gamre, Naresh; Lohar, Sharad Pandurang; Dash, Ashutosh

    2017-09-01

    This paper describes the evaluation of [(R)-2-Amino-3-(4-isothiocyanatophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-pentaacetic acid (CHX-A''-DTPA-NCS) and 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA-NCS) as bifunctional chelators for (177)Lu. While (177)Lu-CHX-A''-DTPA-NCS could be obtained in high yields at equimolar ratios of lutetium to CHX-A''-DTPA-NCS, >95% yield of (177)Lu-NOTA-NCS could be achieved at 1:2M ratio of lutetium to NOTA-NCS. Trace metals reduced the yields of (177)Lu-NOTA-NCS significantly as compared to (177)Lu-CHX-A''-DTPA-NCS. In vitro stability of (177)Lu-CHX-A''-DTPA-NCS was also superior to (177)Lu-NOTA-NCS. It could be concluded from this study that among the two chelators evaluated, CHX-A''-DTPA-NCS is more appropriate for preparation of (177)Lu radiopharmaceuticals. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Peptide receptor radionuclide therapy with (177)Lu DOTATATE in a case of recurrent carotid body paraganglioma with spinal metastases.

    PubMed

    Gupta, Santosh Kumar; Singla, Suhas; Karunanithi, Sellam; Damle, Nishikant; Bal, Chandrasekhar

    2014-05-01

    Paragangliomas are rare benign neuroendocrine tumors, and 80% of all paragangliomas are either carotid body tumors or glomus jugulare tumors. We present a case of recurrent unresectable carotid body paraganglioma with nodal and T7 vertebral metastases in a 30-year-old man 6 years postsurgery detected with Ga DOTANOC PET/CT and was administered with peptide receptor radionuclide therapy using Lu DOTATATE. After 5 cycles of Lu DOTATATE (total cumulative activity of 750 mCi [27 GBq]), significant response at the primary site on Ga DOTANOC PET/CT and complete disappearance of nodal and T7 vertebral metastases were noted.

  11. First principle study of AlX (X=3d, 4d, 5d elements and Lu) dimer.

    PubMed

    Ouyang, Yifang; Wang, Jianchuan; Hou, Yuhua; Zhong, Xiaping; Du, Yong; Feng, Yuanping

    2008-02-21

    The ground state equilibrium bond length, harmonic vibrational frequency, and dissociation energy of AlX (X=3d,4d,5d elements and Lu) dimers are investigated by density functional method B3LYP. The present results are in good agreement with the available experimental and other theoretical values except the dissociation energy of AlCr. The present calculations show that the late transition metal can combine strongly with aluminum compared with the former transition metal. The present calculation also indicates that it is more reasonable to replace La with Lu in the Periodic Table and that the bonding strengths of zinc, cadmium, and mercury with aluminum are very weak.

  12. Stellar Neutron Capture Cross Sections of the Lu and Hf Isotopes

    SciTech Connect

    Wisshak, K.; Voss, F.; Kaeppeler, F.; Kazakov, L.; Krticka, M.

    2005-05-24

    The neutron capture cross sections of 175,176Lu and 176,177,178,179,180Hf have been measured in the energy range from 3 to 225 keV at the Karlsruhe 3.7 MV Van de Graaff accelerator relative to the gold standard. Neutrons were produced by the 7Li(p,n)7Be reaction and capture events were detected by the Karlsruhe 4{pi}BaF2 detector. The cross section ratios could be determined with uncertainties between 0.9 and 1.8% about a factor of five more accurate than previous data. A strong population of isomeric states was found in neutron capture of the Hf isotopes, which are only partially explained by CASINO/GEANT simulations based on the known level schemes.Maxwellian averaged neutron capture cross sections were calculated for thermal energies between kT = 8 keV and 100 keV. Severe differences up to40% were found to the data of a recent evaluation based on existing experimental results. The new data allow for a much more reliable analysis of the important branching in the s-process synthesis path at 176Lu which can be interpreted as an s-process thermometer.

  13. Transparent Lu 2 O 3 :Eu ceramics by sinter and HIP optimization

    NASA Astrophysics Data System (ADS)

    Seeley, Z. M.; Kuntz, J. D.; Cherepy, N. J.; Payne, S. A.

    2011-09-01

    Evolution of porosity and microstructure was observed during densification of lutetium oxide ceramics doped with europium (Lu 2O 3:Eu) fabricated via vacuum sintering and hot isostatic pressing (HIP'ing). Nano-scale starting powder was uniaxially pressed and sintered under high vacuum at temperatures between 1575 and 1850 °C to obtain densities ranging between 94% and 99%, respectively. Sintered compacts were then subjected to 200 MPa argon gas at 1850 °C to reach full density. Vacuum sintering above 1650 °C led to rapid grain growth prior to densification, rendering the pores immobile. Sintering between 1600 and 1650 °C resulted in closed porosity yet a fine grain size to allow the pores to remain mobile during the subsequent HIP'ing step, resulting in a fully-dense highly transparent ceramic without the need for subsequent air anneal. Light yield performance was measured and Lu 2O 3:Eu showed ˜4 times higher light yield than commercially used scintillating glass indicating that this material has the potential to improve the performance of high energy radiography devices.

  14. Composite grid and finite-volume LU implicit scheme for turbine flow analysis

    NASA Technical Reports Server (NTRS)

    Choo, Yung K.; Yoon, Seokkwan; Civinskas, Kestutis C.

    1987-01-01

    A composite grid was generated in an attempt to improve grid quality for a typical turbine blade with large camber in terms of mesh control, smoothness, and orthogonality. This composite grid consists of the C grid (or O grid) in the immediate vicinity of the blade and the H grid in the upstream region and in the middle of the blade passage between the C grids. It provides a good boundary layer resolution around the leading edge region for viscous calculation, has orthogonality at the blade surface and slope continuity at the C-H (or O-H) interface, and has flexibility in controlling the mesh distribution in the upstream region without using excessive grid points. This composite grid eliminates the undesirable qualities of a single grid when generated for a typical turbine geometry. A finite-volume lower-upper (LU) implicit scheme can be used in solving for the turbine flows on the composite grid. This grid has a special grid node that is connected to more than four neighboring nodes in two dimensions and to more than six nodes in three dimensions. But the finite-volume approach poses no problem at the special point because each interior cell has only four neighboring cells in two dimensions and only six cells in three dimensions. The finite-volume LU implicit scheme was demonstrated to be robust and efficient for both external and internal flows in a broad flow regime.

  15. Composite grid and finite-volume LU implicit scheme for turbine flow analysis

    NASA Technical Reports Server (NTRS)

    Choo, Yung K.; Yoon, Seokkwan; Civinskas, Kestutis C.

    1987-01-01

    A composite grid was generated in an attempt to improve grid quality for a typical turbine blade with large camber in terms of mesh control, smoothness, and orthogonality. This composite grid consists of the C grid (or O grid) in the immediate vicinity of the blade and the H grid in the upstream region and in the middle of the blade passage between the C grids. It provides a good boundary layer resolution around the leading edge region for viscous calculation, has orthogonality at the blade surface and slope continuity at the C-H (or O-H) interface, and has flexibility in controlling the mesh distribution in the upstream region without using excessive grid points. This composite grid eliminates the undesirable qualities of a single grid when generated for a typical turbine geometry. A finite-volume lower-upper (LU) implicit schemes can be used in solving for the turbine flows on the composite grid. This grid has a special grid node that is connected to more than four neighboring nodes in two dimensions and to more than six nodes in three dimensions. But the finite-volume approach poses no problem at the special point because each interior cell has only four neighboring cells in two dimensions and only six cells in three dimensions. The finite-volume LU implicit scheme was demonstrated to be robust and efficient for both external and internal flows in a broad flow regime.

  16. Realistic multi-cellular dosimetry for 177Lu-labelled antibodies: model and application

    NASA Astrophysics Data System (ADS)

    Marcatili, S.; Pichard, A.; Courteau, A.; Ladjohounlou, R.; Navarro-Teulon, I.; Repetto-Llamazares, A.; Heyerdahl, H.; Dahle, J.; Pouget, J. P.; Bardiès, M.

    2016-10-01

    Current preclinical dosimetric models often fail to take account of the complex nature of absorbed dose distribution typical of in vitro clonogenic experiments in targeted radionuclide therapy. For this reason, clonogenic survival is often expressed as a function of added activity rather than the absorbed dose delivered to cells/cell nuclei. We designed a multi-cellular dosimetry model that takes into account the realistic distributions of cells in the Petri dish, for the establishment of survival curves as a function of the absorbed dose. General-purpose software tools were used for the generation of realistic, randomised 3D cell culture geometries based on experimentally determined parameters (cell size, cell density, cluster density, average cluster size, cell cumulated activity). A mixture of Monte Carlo and analytical approaches was implemented in order to achieve as accurate as possible results while reducing calculation time. The model was here applied to clonogenic survival experiments carried out to compare the efficacy of Betalutin®, a novel 177Lu-labelled antibody radionuclide conjugate for the treatment of non-Hodgkin lymphoma, to that of 177Lu-labelled CD20-specific (rituximab) and non-specific antibodies (Erbitux) on lymphocyte B cells. The 3D cellular model developed allowed a better understanding of the radiative and non-radiative processes associated with cellular death. Our approach is generic and can also be applied to other radiopharmaceuticals and cell distributions.

  17. Cross sections for fast-neutron interaction with Lu, Tb, and Ta isotopes

    SciTech Connect

    Dzysiuk, N.; Kadenko, I.; Yermolenko, R.; Koning, A. J.

    2010-01-15

    The cross sections for (n,x) reactions with Lu, Tb, and Ta isotopes were measured at (d,t) neutron energies around 14 MeV with the activation technique using metal foils of natural composition. Additionally, tantalum samples were irradiated with (d,d) neutrons and filtered neutron beams. To ensure an acceptable precision of the results all major sources of uncertainties were taken into account. Calculations of efficiency and correction factors were performed with the Monte Carlo technique. The cross section results obtained for the {sup 175}Lu(n,{alpha}){sup 172}Tm reaction at (d,t) neutron energies are reported for the first time. {sup 181}Ta(n,{gamma}){sup 182}Ta{sup m2} reaction cross sections were also measured for the first time at 1.9, 58.7, and 144.3 keV and at 2.85 MeV. The earlier evaluated cross section upper estimate for the nuclear reaction {sup 159}Tb(n,n{sup '}{alpha}){sup 155}Eu is reported in this article to be one order lower. Some other cross sections were obtained with higher precision. Theoretical calculations of excitation functions were performed with the TALYS-1.0 code and compared with the experimental cross section values.

  18. Characterization of 176Lu background in LSO-based PET scanners

    NASA Astrophysics Data System (ADS)

    Conti, Maurizio; Eriksson, Lars; Rothfuss, Harold; Sjoeholm, Therese; Townsend, David; Rosenqvist, Göran; Carlier, Thomas

    2017-05-01

    LSO and LYSO are today the most common scintillators used in positron emission tomography. Lutetium contains traces of 176Lu, a radioactive isotope that decays β - with a cascade of γ photons in coincidence. Therefore, Lutetium-based scintillators are characterized by a small natural radiation background. In this paper, we investigate and characterize the 176Lu radiation background via experiments performed on LSO-based PET scanners. LSO background was measured at different energy windows and different time coincidence windows, and by using shields to alter the original spectrum. The effect of radiation background in particularly count-starved applications, such as 90Y imaging, is analysed and discussed. Depending on the size of the PET scanner, between 500 and 1000 total random counts per second and between 3 and 5 total true coincidences per second were measured in standard coincidence mode. The LSO background counts in a Siemens mCT in the standard PET energy and time windows are in general negligible in terms of trues, and are comparable to that measured in a BGO scanner of similar size.

  19. Zircon Lu-Hf systematics: Evidence for the episodic development of Archaean greenstone belts

    NASA Technical Reports Server (NTRS)

    Smith, P. E.; Tatsumoto, M.; Farquhar, R. M.

    1986-01-01

    A combined U-Th-Pb and Lu-Hf isotopic study of zircons was undertaken in order to determine the provenance and age of an Archean granite-greenstone terrain and to test the detailed application of the Lu-Hf system in various Archean zircons. The eastern Wawa subprovince of the Superior province consists of the low grade Michipicoten and Gamitagama greenstone belts and the granitic terrain. The Hf isotopic data indicate that the typical lithological features of a greenstone belt cycle could be accommodated in a crustal growth model that involved decreasing depth of melting in three isotopically distinct reservoirs: mantle, lower crust and upper crust. The model age of the sources given by the intersection of the lower crustal curve with the bulk earth evolution curve is about 2900 My, in good agreement with the zircon U-Pb basement age. This linear array also has a similar intersection age to that of Proterozoic carbonatite complexes. The general convergence of the other reservoir vectors around this age suggests that mantle depletion, crustal extraction and intracrustal differentiation were all part of the same episodic event. It is also apparent that recycling of older basement was important in the formation of many of the later greenstone belt rocks.

  20. Uncertainty propagation for SPECT/CT-based renal dosimetry in 177Lu peptide receptor radionuclide therapy

    NASA Astrophysics Data System (ADS)

    Gustafsson, Johan; Brolin, Gustav; Cox, Maurice; Ljungberg, Michael; Johansson, Lena; Sjögreen Gleisner, Katarina

    2015-11-01

    A computer model of a patient-specific clinical 177Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability of renal absorbed dose and biologically effective dose (BED) estimates. As patient models, three anthropomorphic computer phantoms coupled to a pharmacokinetic model of 177Lu-DOTATATE are used. Aspects included in the dosimetry-process model are the gamma-camera calibration via measurement of the system sensitivity, selection of imaging time points, generation of mass-density maps from CT, SPECT imaging, volume-of-interest delineation, calculation of absorbed-dose rate via a combination of local energy deposition for electrons and Monte Carlo simulations of photons, curve fitting and integration to absorbed dose and BED. By introducing variabilities in these steps the combined uncertainty in the output quantity is determined. The importance of different sources of uncertainty is assessed by observing the decrease in standard deviation when removing a particular source. The obtained absorbed dose and BED standard deviations are approximately 6% and slightly higher if considering the root mean square error. The most important sources of variability are the compensation for partial volume effects via a recovery coefficient and the gamma-camera calibration via the system sensitivity.

  1. Magnetization dynamics and frustration in the multiferroic double perovskite Lu2MnCoO6

    DOE PAGES

    Zapf, Vivien S.; Ueland, B. G.; Laver, Mark; ...

    2016-04-29

    Here, we investigate the magnetic ordering and the magnetization dynamics (from kHz to THz time scales) of the double perovskite Lu2MnCoO6 using elastic neutron diffraction, muon spin relaxation, and micro-Hall magnetization measurements. This compound is known to be a type II multiferroic with the interesting feature that a ferromagneticlike magnetization hysteresis loop couples to an equally hysteretic electric polarization in the bulk of the material despite a zero-field magnetic ordering of the type ↑↑↓↓ along Co-Mn spin chains. Here we explore the unusual dynamics of this compound and find extremely strong fluctuations, consistent with the axial next-nearest-neighbor Ising (ANNNI) modelmore » for frustrated spin chains. We identify three temperature scales in Lu2MnCoO6 corresponding to the onset of highly fluctuating long-range order below TN = 50±3 K identified from neutron scattering, the onset of magnetic and electric hysteresis, with change in kHz magnetic and electric dynamics below a 30 K temperature scale, and partial freezing of ~MHz spin fluctuations in the muon spin relaxation data below 12 ± 3 K. Our results provide a framework for understanding the multiferroic behavior of this compound and its hysteresis and dynamics.« less

  2. [Comparison of academic viewpoints between Yun Tie-qiao and Lu Yuan-lei].

    PubMed

    Yang, Zhi-qing; Bi, Li-juan; Yang, Xing-lin

    2010-07-01

    Both Yun Tie-qiao and Lu Yuan-lei are medical professionals coming from the literary field with versatile and in-depth knowledge and extensive experience in medical education and clinical practice, all closely related to modern TCM development. Yun, the elder, insisted on reforming TCM and was early to advocate the academic idea of amalgamating western and traditional Chinese medicine; while Lu, the younger, insisted on the idea of "scientizing TCM" and was the representative of amalgamating western and traditional Chinese medicine in the later stage. They shared many common viewpoints, including venerating Zhang Zhongjing, stressing exogenous cold pathogens, advocating reformation and amalgamation of western medicine and TCM and objecting to the abolishment of TCM. However, there were discrepancies between them, including the relationship between the Inner Canon and the Essay on Exogenous Cold Diseases, warm disease theory, pulse theory, titles of TCM diseases and Japanese Kampo medicine. A comparison of them and noting their valuable contributions will be beneficial for the promotion of the development of TCM.

  3. Composition and hygroscopicity of aerosol particles at Mt. Lu in South China: Implications for acid precipitation

    NASA Astrophysics Data System (ADS)

    Li, Weijun; Chi, Jianwei; Shi, Zongbo; Wang, Xinfeng; Chen, Bin; Wang, Yan; Li, Tao; Chen, Jianmin; Zhang, Daizhou; Wang, Zifa; Shi, Chune; Liu, Liangke; Wang, Wenxing

    2014-09-01

    Physicochemical properties of aerosol particles were studied at Mt. Lu, an elevated site (115°59‧E, 29°35‧N, 1165 m) within the acid precipitation area. Northeast winds transport copious amounts of air pollutants and water vapor from the Yangtze River Delta into this acid precipitation area. NH4+ and SO42- are the dominant ions in PM2.5 and determine aerosol acidity. Individual particle analysis shows abundant S-rich and metals (i.e. Fe-, Zn-, Mn-, and Pb-rich) particles. Unlike aerosol particles in North China and urban areas, there are little soot and mineral particles at Mt. Lu. Lack of mineral particles contributed to the higher acidity in precipitation in the research area. Nano-sized spherical metal particles were observed to be embedded in 37% of S-rich particles. These metal particles were likely originated from heavy industries and fired-power plants. Hygroscopic experiments show that most particles start to deliquesce at 73-76% but organic coating lowers the particle deliquescence relative humidity (DRH) to 63-73%. The DRHs of these aerosol particles are clearly smaller than that of pure ammonium sulfate particles which is 80%. Since RH in ambient air was relatively high, ranging from 65% to 85% during our study period, most particles at our sampling site were in liquid phase. Our results suggest that liquid phase reactions in aerosol particles may contribute to SO2 to sulfuric acid conversion in the acid precipitation area.

  4. Importance of the Lu-Hf isotopic system in studies of planetary chronology and chemical evolution

    NASA Technical Reports Server (NTRS)

    Patchett, P. J.

    1983-01-01

    The Lu-176-Hf-176 isotope method and its applications in earth sciences are discussed with regard to planetary-evolution studies. From new data on basalts from oceanic islands, Hf-176/Hf-177 and Nd-143/Nd-144 are found to display a single linear isotopic variation in the suboceanic mantle, whereas considerable divergences occur in Hf-176/Hf-177-Sr-87/Sr-86 and Nd-143/Nd-144-Sr87/Sr-86 diagrams. With the acquisition of further Hf-Sr-Nd isotopic data, these discordant Sr-87/Sr-86 relationships may allow a distinction between processes such as mantle metasomatism, influence of sea-water altered material in the magma source, or recycling of sediments into the mantle. The best quality Hf isotope data are obtained from granitoid or zircons, and are most suitable for studying ancient terrestrial Hf isotopic variations. Lu-Hf is shown to be a viable method for dating ancient terrestrial and extraterrestrial samples, but is unlikely to find wide application in pure chronological studies because it offers little advantage over existing methods.

  5. Microstructure and deuterium retention after ion irradiation of W-Lu2O3 composites

    NASA Astrophysics Data System (ADS)

    Lin, Jin-Shan; Luo, Lai-Ma; Xu, Qiu; Zan, Xiang; Zhu, Xiao-Yong; Wu, Yu-Cheng

    2017-07-01

    W-3Lu2O3 composites were prepared by mechanical milling and spark plasma sintering. The obtained composites were subjected to He+ irradiation experiments. The irradiated samples were characterized by X-ray diffraction, field-emission scanning electron microscopy, transmission electron microscopy, and measurement of Vickers hardness. Thermal desorption spectroscopy analysis was performed to analyze the samples at different damage levels after Fe2+ and D+ irradiation. Results showed varied degrees of He+ damage under different energies. Fuzz structures were observed on the surface of the material after irradiation. TEM results indicated that the existence of these fuzz structures was related to the formation of He bubbles. Amorphous, polycrystalline, and γ-W phases formed in areas where He bubbles existed. The measured Vickers hardness proved that radiation hardening occurred after irradiation. After Fe2+ irradiation at different damage levels, the total retained deuterium amount of W-3Lu2O3 and pure W differed, and the impact of Fe2+ radiation for deuterium retention on pure tungsten was greater.

  6. Femtosecond laser excitation of coherent optical phonons in ferroelectric LuMnO3

    NASA Astrophysics Data System (ADS)

    Lou, Shi-Tao; Zimmermann, Frank M.; Bartynski, Robert A.; Hur, Namjung; Cheong, Sang-Wook

    2009-06-01

    We have used femtosecond pump-probe spectroscopy to excite and probe coherent optical phonon vibrations in single crystals of hexagonal ferroelectric LuMnO3 . An optical phonon mode of A1 symmetry was coherently excited with 25 fs pump-laser pulses (λ≈800nm) . The phonon mode, involving Lu ion motion along the c axis, was identified as the soft mode driving the ferroelectric transition. The excitation mechanism was determined to be purely displacive in nature due to resonant excitation of a narrow intra-atomic dxy,x2-y2→d3z2-r2 transition in Mn. The lifetime of the Mndxy,x2-y2→d3z2-r2 excitation was measured to be 0.8 ps. A remarkable reversal of the sign of the oscillation amplitude ( π phase shift) of the reflectivity curve was observed upon comparing longitudinal-optical (LO) with transverse-optical (TO) mode geometries. The phase reversal is attributed to the macroscopic electric depolarization field accompanying infrared-active longitudinal phonon modes but absent in TO modes. In addition to the direct effect of the ion motion on the optical properties, which is the same in LO and TO modes, the longitudinal depolarization field of the LO mode gives rise to an additional modulation of the refractive index via the linear electro-optic effect which dominates the optical response.

  7. Electric Field Effect on the Magnetic Order in Multiferroic LuMnO3

    NASA Astrophysics Data System (ADS)

    Duan, Chunruo; Yang, Junjie; Harriger, Leland; Louca, Despina

    LuMnO3 belongs to the family of hexagonal multiferroics in which ferroelectric and magnetic orders coexist and compete. The Mn3+ ions reside on a triangular lattice that is geometrically frustrated but undergoes a Neel transition at TN ~90 K. Neutron experiments under electric field were carried out on a single crystal of LuMnO3 at SPINS to investigate the coupling of the electric field to the magnetic order. The elastic and inelastic scattering around the commensurate (101) magnetic peak and the Mn trimerization induced (100) peak with and without electric field were investigated. When applying an E-field of 13.3 kV/cm along the (001) direction on an unpoled sample, an increase in (101) peak as well as a shift of the inelastic excitation near (100) to higher ΔE have been observed. Once the sample is polarized, these effects exist without the field. On the other hand, an E-field along (110) direction shows almost no effect. The spin arrangement of the magnetic order is within the ab-plane, thus the Dzyaloshinskii-Moriya interaction explains why a polarization perpendicular to the magnetic moment gives a larger effect. The implication will be discussed.

  8. Origin of room-temperature multiferroism in hexagonal LuFeO3

    NASA Astrophysics Data System (ADS)

    Wu, Xifan; Wang, Hongwei; Solovyev, Igor; Shen, Jian; Wang, Wenbin; Wang, Xiao; Cheng, Xuemei; He, Lixin; Xu, Xiaoshan

    2014-03-01

    Combined theoretical and experimental studies are carried out, focusing on the exchange interactions and their couplings with the structural instabilities in hexagonal LuFeO3 (hLFO). We apply an extended Kugel-Khomskii model based on maximally localized Wannier functions generated from band structure calculations. The model clearly shows that the single occupied dz2 orbital in hLFO greatly increases the exchange coupling compared to that of hexagonal LuMnO3 in which dz2 is empty. The interlayer exchange interaction is the key to the spin reorientation (SR) and weak ferromagnetic moment observed below 130K. Our calculations show that SR is strongly coupled to the K1 phonon mode and only weakly dependent on K3 and Γ2- phonons. It indicates that the atomic displacements along positive direction of K1 mode is responsible for the spin reorientation. This scenario is confirmed by our X-ray diffraction and X-ray absorption experiments. In the end, we propose that TSR can be adjusted to be room temperature by structural competition between K1 and Γ2- modes in hLFO or by interface engineering.

  9. Antiferromagnetic Resonance in Multiferroic YMnO3 and LuMnO3

    NASA Astrophysics Data System (ADS)

    Zvyagin, Sergei

    2009-03-01

    Multiferroic rare-earth manganites have attracted much attention because of the coexistence of ferroelectric and magnetic orders. Combining conventional far-infrared Fourier-transform and THz-range free electron laser electron spin resonance (ESR) spectroscopy techniques, magnetic excitations in hexagonal multiferroic YMnO3 and LuMnO3 in the antiferromagnetically (AFM) ordered phase have been studied. The gap in the excitation spectrum (˜42 and ˜48 cm-1 for YMnO3 and LuMnO3, respectively) was observed directly. Similar slope of the frequency-field dependences of AFM resonance modes, ˜ 0.5 cm-1/T, was revealed for both compounds. A fine structure of AFM resonance absorption has been revealed by means of high-resolution ESR techniques, which can be explained taking into account a finite interaction between the neighboring Mn^3+ layers. The work was done in collaboration with M. Ozerov, D. Kamensky, E. Cizm'ar, J. Wosnitza, A.K. Kolezhuk, D. Smirnov, H.D. Zhou, and C.R. Wiebe.

  10. Magnon breakdown in a two dimensional triangular Heisenberg antiferromagnet LuMnO3

    NASA Astrophysics Data System (ADS)

    Oh, Joosung; Le, Manh-Duc; Jeong, Jaehong; Park, Je-Geun; Lee, Jung-Hyun; Song, Wan-Young; Perring, T. G.; Woo, Hyungje; Buyers, W. J. L.; Cheong, S.-W.

    2014-03-01

    Magnons, the quasi-particles of long range ordered magnetic systems, have long been viewed as long lived excitations with spectra that are well described by linear spin wave theory (LSWT). Recent theoretical works, though, suggest that the magnon spectrum of 2D triangular Heisenberg antiferromagnet (THA) is highly renormalized downward with a roton-like minimum at the M point. This, as well as the decay of single magnons into two magnon states, was interpreted as the effects of a cubic interaction between magnons arising from the noncollinear spin structure LuMnO3 is a good 2D THA candidate to test this prediction since it has a noncollinear 120° spin structure with S =2. We have conducted inelastic neutron scattering experiments using a LuMnO3 single crystal. Much of the observed spectrum is well described by LSWT, but, a closer inspection of the M point show deviations: a minimum at the lowest energy mode, a flat dispersion at upper modes and line width broadening at the top of the dispersion due to magnon decay. These features agree qualitatively with the theoretical predictions, revealing the importance of the cubic interaction between magnons in 2D THA

  11. Realistic multi-cellular dosimetry for (177)Lu-labelled antibodies: model and application.

    PubMed

    Marcatili, S; Pichard, A; Courteau, A; Ladjohounlou, R; Navarro-Teulon, I; Repetto-Llamazares, A; Heyerdahl, H; Dahle, J; Pouget, J P; Bardiès, M

    2016-10-07

    Current preclinical dosimetric models often fail to take account of the complex nature of absorbed dose distribution typical of in vitro clonogenic experiments in targeted radionuclide therapy. For this reason, clonogenic survival is often expressed as a function of added activity rather than the absorbed dose delivered to cells/cell nuclei. We designed a multi-cellular dosimetry model that takes into account the realistic distributions of cells in the Petri dish, for the establishment of survival curves as a function of the absorbed dose. General-purpose software tools were used for the generation of realistic, randomised 3D cell culture geometries based on experimentally determined parameters (cell size, cell density, cluster density, average cluster size, cell cumulated activity). A mixture of Monte Carlo and analytical approaches was implemented in order to achieve as accurate as possible results while reducing calculation time. The model was here applied to clonogenic survival experiments carried out to compare the efficacy of Betalutin(®), a novel (177)Lu-labelled antibody radionuclide conjugate for the treatment of non-Hodgkin lymphoma, to that of (177)Lu-labelled CD20-specific (rituximab) and non-specific antibodies (Erbitux) on lymphocyte B cells. The 3D cellular model developed allowed a better understanding of the radiative and non-radiative processes associated with cellular death. Our approach is generic and can also be applied to other radiopharmaceuticals and cell distributions.

  12. Novel High Efficiency Microcolumnar LuI3:Ce for Hard X-ray Imaging

    NASA Astrophysics Data System (ADS)

    Marton, Z.; Nagarkar, Vivek V.; Miller, Stuart R.; Brecher, Charles; Bhandari, Harish B.; Kenesei, Peter; Ross, Stephen K.; Almer, Jonathan D.; Singh, Bipin

    2014-03-01

    We have developed a structured scintillator using a vacuum deposition technique that is suitable for manufacturing large area scintillators in a microcolumnar form. While providing high absorption efficiency, it also allows great temporal and spatial resolution X-ray imaging. Microcolumnar films of extremely fast and bright cerium-doped lutetium iodide (LuI3:Ce) scintillator were synthesized. It has high density (~5.6 g/cm3), high effective atomic number (59.7), bright green emission (540 nm range, well matched to commercial optics and CCD sensors), light yield exceeding 115,000 ph/MeV, and rapid, afterglow-free decay (~28 ns). This new scintillator could resolve the 153 ns bunch structure of the Advanced Photon Source (APS) at Argonne National Laboratory (ANL). Due to the fast, afterglow-free decay, and high efficiency of LuI3:Ce, during the experiments performed at the 1-ID hard X-ray beamline at the APS, single 65 keV X-ray photons could be resolved with high signal-to-noise ratio and with temporal resolution better than 20ns. In the future, it will enable a wide range of hard X-ray (20 keV to 100 keV) imaging and/or high frame-rate applications such as dynamic studies of the structural and electrochemical properties of batteries using microtomographic X-ray imaging, internal corrosion in fuel cells, and time-resolved muscle diffraction experiments.

  13. Theoretical investigation of the lowest-lying electronic structure of LuI molecules

    NASA Astrophysics Data System (ADS)

    Assaf, J.; Taher, F.; Magnier, S.

    2014-01-01

    CASSCF/MRCI calculations using Effective Core Potential (ECP) basis sets for both Lu and I atoms, have been performed for the first 22 electronic states in the representation 2s+1Λ(±) for the LuI molecule. This investigation included the corresponding 43 molecular states in the representation Ω(±) when taking the spin-orbit coupling (SOC) in consideration. Calculated potential energy curves (PECs) have been displayed. Spectroscopic constants Te, ωe, ωeχe, Be and the internuclear distance Re have been calculated for the ground state and for the low-lying electronic states situated below 40,410 cm-1 and for their corresponding components with SOC. The transition dipolar moments between states have been given at the minimum position Re = 2.75 Å of the ground state X1Σ+. The calculated set of singlet and triplet states provides a theoretical prediction for more than 19 yet unobserved electronic states.

  14. Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus

    PubMed Central

    Wang, Ling; Qiu, Xue-Min; Gui, Yu-Yan; Xu, Ying-Ping; Gober, Hans-Jürgen; Li, Da-Jin

    2015-01-01

    Introduction Bu-Shen-Ning-Xin Decoction (BSNXD), a traditional Chinese medicinal composition, has been used as a remedy for postmenopausal osteoporosis, but its effects on bone metabolism and the uterus have not been reported. Purpose We aimed to determine the respective effects of BSNXD on the bones and the uterus of ovariectomized (OVX) mice to evaluate the efficacy and safety of this herbal formula. Materials and methods Postmenopausal osteoporosis animal models that were generated by ovariectomy were treated with BSNXD. Dual-energy X-ray absorptiometry was performed to analyze the bone mineral density, and histomorphometric analysis was performed to measure the parameters related to bone metabolism. Calcein labeling was performed to detect bone formation. The uteruses from the mice were weighed, and the histomorphometry was analyzed. Drug-derived serum was prepared to assess the 17-β-estradiol concentration via enzyme immunoassay. Results BSNXD administration ameliorated the osteoporotic phenotype of OVX mice, as evidenced by an increase in the bone mineral density and bone volume; these effects could not be abolished by the administration of the aromatase inhibitor letrozole. Moreover, BSNXD had no effect on the serum estrogen concentration or uterus. Conclusion These results suggest that BSNXD has ameliorating effects on bone loss due to estrogen deprivation without affecting the peripheral blood estrogen concentration or the uterus in OVX mice. PMID:26357466

  15. Impact of parameter fluctuations on the performance of ethanol precipitation in production of Re Du Ning Injections, based on HPLC fingerprints and principal component analysis.

    PubMed

    Sun, Li-Qiong; Wang, Shu-Yao; Li, Yan-Jing; Wang, Yong-Xiang; Wang, Zhen-Zhong; Huang, Wen-Zhe; Wang, Yue-Sheng; Bi, Yu-An; Ding, Gang; Xiao, Wei

    2016-01-01

    The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections, including concentrate density, concentrate temperature, ethanol content, flow rate and stir rate in the addition of ethanol, precipitation time, and precipitation temperature. Under the experimental and simulated production conditions, a series of precipitated resultants were prepared by changing these variables one by one, and then examined by HPLC fingerprint analyses. Different from the traditional evaluation model based on single or a few constituents, the fingerprint data of every parameter fluctuation test was processed with Principal Component Analysis (PCA) to comprehensively assess the performance of ethanol precipitation. Our results showed that concentrate density, ethanol content, and precipitation time were the most important parameters that influence the recovery of active compounds in precipitation resultants. The present study would provide some reference for pharmaceutical scientists engaged in research on pharmaceutical process optimization and help pharmaceutical enterprises adapt a scientific and reasonable cost-effective approach to ensure the batch-to-batch quality consistency of the final products.

  16. Multiscale Modeling of Drug-induced Effects of ReDuNing Injection on Human Disease: From Drug Molecules to Clinical Symptoms of Disease

    NASA Astrophysics Data System (ADS)

    Luo, Fang; Gu, Jiangyong; Zhang, Xinzhuang; Chen, Lirong; Cao, Liang; Li, Na; Wang, Zhenzhong; Xiao, Wei; Xu, Xiaojie

    2015-05-01

    ReDuNing injection (RDN) is a patented traditional Chinese medicine, and the components of it were proven to have antiviral and important anti-inflammatory activities. Several reports showed that RDN had potential effects in the treatment of influenza and pneumonia. Though there were several experimental reports about RDN, the experimental results were not enough and complete due to that it was difficult to predict and verify the effect of RDN for a large number of human diseases. Here we employed multiscale model by integrating molecular docking, network pharmacology and the clinical symptoms information of diseases and explored the interaction mechanism of RDN on human diseases. Meanwhile, we analyzed the relation among the drug molecules, target proteins, biological pathways, human diseases and the clinical symptoms about it. Then we predicted potential active ingredients of RDN, the potential target proteins, the key pathways and related diseases. These attempts may offer several new insights to understand the pharmacological properties of RDN and provide benefit for its new clinical applications and research.

  17. Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus.

    PubMed

    Wang, Ling; Qiu, Xue-Min; Gui, Yu-Yan; Xu, Ying-Ping; Gober, Hans-Jürgen; Li, Da-Jin

    2015-01-01

    Bu-Shen-Ning-Xin Decoction (BSNXD), a traditional Chinese medicinal composition, has been used as a remedy for postmenopausal osteoporosis, but its effects on bone metabolism and the uterus have not been reported. We aimed to determine the respective effects of BSNXD on the bones and the uterus of ovariectomized (OVX) mice to evaluate the efficacy and safety of this herbal formula. Postmenopausal osteoporosis animal models that were generated by ovariectomy were treated with BSNXD. Dual-energy X-ray absorptiometry was performed to analyze the bone mineral density, and histomorphometric analysis was performed to measure the parameters related to bone metabolism. Calcein labeling was performed to detect bone formation. The uteruses from the mice were weighed, and the histomorphometry was analyzed. Drug-derived serum was prepared to assess the 17-β-estradiol concentration via enzyme immunoassay. BSNXD administration ameliorated the osteoporotic phenotype of OVX mice, as evidenced by an increase in the bone mineral density and bone volume; these effects could not be abolished by the administration of the aromatase inhibitor letrozole. Moreover, BSNXD had no effect on the serum estrogen concentration or uterus. These results suggest that BSNXD has ameliorating effects on bone loss due to estrogen deprivation without affecting the peripheral blood estrogen concentration or the uterus in OVX mice.

  18. Lu-Hf Isotope Systematics of the Nuvvuagittuq Supracrustal Belt (Québec, Canada)

    NASA Astrophysics Data System (ADS)

    Guitreau, M.; Blichert-Toft, J.; Mojzsis, S. J.; Roth, A. S.; Bourdon, B.

    2012-12-01

    The Nuvvuagittuq supracrustal belt (NSB) in northern Québec (Canada) is a mafic terrane enclosed in the westernmost part of the Minto Block of the Superior Province. This locality became famous after the discovery by [1] of 142Nd deficits in the constituent amphibolites. The age of the NSB is a matter of debate because zircon U-Pb and whole-rock 147Sm-143Nd isotope systematics give Eoarchean ages of ~3.8 Ga, while the short-lived 146Sm-142Nd chronometer indicates a Hadean age of ~4.3 Ga. We present new Lu-Hf isotope data for mafic and felsic rocks from the NSB in an attempt to resolve this age issue and, hence, understand the origin of the negative 142Nd anomalies. The Lu-Hf data define a "scatterchron" yielding an Eoarchean age of 3864±70 Ma, which is consistent with 147Sm-143Nd and U-Pb zircon ages but in disagreement with the Hadean age inferred from 146Sm-142Nd systematics. We interpret the Lu-Hf age as the mean emplacement age of the different autochthonous units of the NSB. The observed alignment of the data along a Lu-Hf "scatterchron" precludes a Hadean age for the NSB because their isotopic characteristics appear to be controlled by long-term radiogenic ingrowth. A Hadean derivation should have caused age differences of hundreds of millions of years to manifest as strong deviations from the observed scatterchron. Furthermore, combined Lu-Hf and Sm-Nd data on the same NSB (Ca-poor cummingtonite- and hornblende-bearing) amphibolite samples define a mixing hyperbola at ca. 3800 Ma with end-member compositions representative of compositional groupings identified for these lithologies [2]. Low 142Nd/144Nd values relative to Bulk Silicate Earth are endemic to the "low-TiO2" amphibolite population, and can be attributed to a Hadean multi-stage history of its mantle source as indicated by rare-earth element patterns. The 142Nd deficits could have developed in response to a later re-fertilization episode within a mantle source depleted by primordial crust

  19. Sm/Nd and Lu/Hf ratios of the Earth primitive mantle

    NASA Astrophysics Data System (ADS)

    Kostitsyn, Yu. A.

    2003-04-01

    The most popular isotopic models of the Earth mantle composition suggest following DePaolo and Wasserburg (1976) that Sm-Nd systematic of the primitive mantle (PriMa) is identical to the chondritic uniform reservoir (CHUR) with Sm/Nd=0.325 and today 143Nd/144Nd=0.512638. Corresponding values were found for Lu-Hf system as well: Lu/Hf=0.235 and 176Hf/177Hf=0.28286 (Tatsumoto et.al., 1981). However, there is no such a correspondence between PriMa and CHUR compositions in Rb-Sr or U-Pb isotopic systems. The idea about similarity of the PriMa and chondrites in Sm-Nd system, despite of its attraction, never was strictly proved, and analysis of isotopic data for different mantle rocks reveal a number of problems: 1. The most productive source on the Earth is DM despite an obvious suggestion that it should be more inert than undepleted mantle. CHUR-like PriMa, with zero Epsilon-Nd, does not exhibit itself by some rocks with regular isotopic composition. We all mutely accept this, using for model ages assessments TNd(DM), not TNd(CHUR). 2. Alkali basalts, enriched in incompatible elements, mostly have positive Epsilon-Nd and in terms of CHUR-based model must originate from the depleted mantle. 3. Origin of HIMU basalts is extremely controversial in terms of CHUR-based geochemical models. Their source is enriched in terms of U-Pb system but depleted in Rb-Sr and Sm-Nd systems (Epsilon-Nd=+5.0+/-1.4, Epsilon-Sr=-26+/-6). 4. There are absent any rock groups on the Earth having concurrently both Nd isotopic ratios and Sm/Nd ratios near CHUR composition. 5. Mass-balance for Sm-Nd and Lu-Hf isotopic systems constrains a source volume for continental crust by 1/4 to 1/6 of the whole mantle. However, many elements (Rb, U, Pb...) in this case could not be balanced. Seismic tomography studies suggest as well that the lower mantle is not dead and participates in the geodynamic processes documented at the surface by magmatic rocks. If whole mantle was involved in a continental crust

  20. Therapeutic efficacy of 177Lu-CHX-A″-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy

    PubMed Central

    Kelly, Marcus P; Lee, Sze Ting; Lee, F-T; Smyth, Fiona E; Davis, Ian D.; Brechbiel, Martin W; Scott, Andrew M

    2008-01-01

    Background This study investigated the biodistribution and therapeutic efficacy of Lutetium-177 (177Lu) radiolabeled anti-Lewis Y monoclonal antibody hu3S193 radioimmunotherapy (RIT) in mice bearing prostate cancer xenografts. The ability of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitor AG1478 and docetaxel chemotherapy to enhance the efficacy of RIT was also assessed in vivo. Methods The in vitro cytotoxicity of 177Lu labeled hu3S193 on Ley positive DU145 prostate cancer cells was assessed using proliferation assays, with induction of apoptosis measured by ELISA. The in vivo biodistribution and tumor localization of 177Lu-hu3S193 was assessed in mice bearing established DU145 tumor xenografts. The efficacy and maximum tolerated dose of 177Lu-hu3S193 RIT in vivo was determined by a dose escalation study. EGFR inhibitor AG1478 or docetaxel chemotherapy was administered at sub-therapeutic doses in conjunction with RIT in vivo. Results 177Lu-hu3S193 mediated significant induction of cytotoxicity and apoptosis in vitro. In vivo analysis of 177Lu-hu3S193 biodistribution demonstrated specific targeting of DU145 prostate cancer xenografts, with maximal tumor uptake of 33.2 ± 3.9 %ID/g observed at 120 hr post injection. In RIT studies, 177Lu-hu3S193 caused specific and dose-dependent inhibition of prostate cancer tumor growth. A maximum tolerated dose of 350μCi was determined for 177Lu-hu3S193. Combination of 177Lu-hu3S193 RIT with EGFR inhibitor AG1478 or docetaxel chemotherapy both significantly improved efficacy. Conclusions 177Lu-hu3S193 RIT is effective as a single agent in the treatment of Ley positive prostate cancer models. The enhancement of RIT by AG1478 or docetaxel indicates the promise of combined modality strategies. PMID:18942092

  1. Development of a large-area monolithic 4×4 MPPC array for a future PET scanner employing pixelized Ce:LYSO and Pr:LuAG crystals

    NASA Astrophysics Data System (ADS)

    Kato, T.; Kataoka, J.; Nakamori, T.; Miura, T.; Matsuda, H.; Sato, K.; Ishikawa, Y.; Yamamura, K.; Kawabata, N.; Ikeda, H.; Sato, G.; Kamada, K.

    2011-05-01

    We have developed a new type of large-area monolithic Multi-Pixel Photon Counter (MPPC) array consisting of a 4×4 matrix of 3×3 mm 2 pixels. Each pixel comprises 3600 Geiger mode avalanche photodiodes (APDs) that achieve an average gain of 9.68×10 5 at 71.9 V at 0 °C with variations of only ±7.2% over 4×4 pixels. Excellent uniformity was also obtained for photon detection efficiencies (PDE) of ±6.4%, whilst dark count rates at the single photoelectron (1 p.e.) level amounted to ≃2 Mcps/pixel, measured at 0 °C. As the first step toward using the device in scintillation photon detectors, we fabricated a prototype gamma-ray camera consisting of an MPPC array optically coupled with a scintillator matrix, namely a 4×4 array of 3×3 ×10 mm 3 crystals. Specifically, we tested the performance with Ce-doped (Lu, Y) 2(SiO 4)O (Ce:LYSO), Pr-doped Lu 3Al 5O 12 (Pr:LuAG) and "surface coated" Pr:LuAG (Pr:LuAG (WLS)) matrices whereby the emission peak of Pr:LuAG was shifted from 310 to 420 nm via a wavelength shifter (WLS). Average energy resolutions of 13.83%, 14.70% and 13.96% (FWHM) were obtained for 662 keV gamma-rays, as measured at 0 °C with Ce:LYSO, Pr:LuAG and Pr:LuAG (WLS) scintillator matrices, respectively. We confirmed that the effective PDE for Pr:LuAG (WLS) had improved by more than 30% compared to original, non-coated Pr:LuAG matrix. These results suggest that a large-area monolithic MPPC array developed here could be promising for future medical imaging, particularly in positron emission tomography (PET).

  2. Lu-Hf dating of garnet from MCCs in the Woodlark Rift of southeastern Papua New Guinea

    NASA Astrophysics Data System (ADS)

    Zirakparvar, N. A.; Baldwin, S.; Vervoort, J. D.; Fitzgerald, P. G.

    2009-12-01

    The youngest known HP-UHP terrane is exposed in the lower plates of metamorphic core complexes within the Woodlark Rift of southeastern Papua New Guinea. Lu-Hf garnet analyses were undertaken on lower plate rocks in order to better resolve the metamorphic history of this region and to gain insight into the timing of garnet growth in relation to the history of HP-UHP exhumation in the Woodlark Rift. Six garnet and two whole-rock fractions from a coesite eclogite on Tumagabuna Island yielded a Lu-Hf isochron age of 7.1 ± 0.7 Ma (MSWD = 1.2; initial 176Hf/177Hf of 0.282098 ± 19, ɛHf(7 Ma) = +11.2). Lu profiles, determined by LA-ICP-MS, across several 2-3 mm garnets in the coesite eclogite all yielded flat patterns. We interpret the ~7 Ma garnet age from this sample to represent the time of Lu-Hf isotopic closure associated with UHP metamorphism. This age is also concordant with in-situ U-Pb zircon ion microprobe ages from coesite eclogite (Monteleone et al., 2007). At Misima Island on the southern rifted margin, four garnet separates, an amphibole, a pyroxene, and a whole rock from a lower plate amphibolite yielded a Lu-Hf age of 12.8 ± 3.4 Ma (MSWD = 2.1; initial 176Hf/177Hf = 0.283079 ± 34, ɛ Hf(12.8 Ma)= 10.7). Lu profiling of garnet did not reveal any zoning, and we interpret the ~13 Ma garnet age to reflect garnet growth during amphibolite facies metamorphism, prior to rifting in the Woodlark Basin. An isochron constructed from five garnet fractions and a whole-rock from a mafic boudin in mylonitic gneiss within the shear zone carapace bounding the Goodenough Island MCC yielded a Lu-Hf age of 65 ± 6 Ma (MSWD = 71; initial 176Hf/177Hf = 0.282630 ± 530 ɛHf(65 Ma) = -4). Lu profiling of a large garnet (1-2 cm) revealed that there is 4 to 6 times as much Lu in a 5-6 mm diameter area in the core of the garnet compared to the rim, leading to our interpretation that the ~65 Ma age reflects garnet growth during prograde metamorphism. This garnet Lu-Hf age is

  3. Radiation Nanomedicine for EGFR-Positive Breast Cancer: Panitumumab-Modified Gold Nanoparticles Complexed to the β-Particle-Emitter, (177)Lu.

    PubMed

    Yook, Simmyung; Cai, Zhongli; Lu, Yijie; Winnik, Mitchell A; Pignol, Jean-Philippe; Reilly, Raymond M

    2015-11-02

    Our objective was to construct a novel radiation nanomedicine for treatment of breast cancer (BC) expressing epidermal growth factor receptors (EGFR), particularly triple-negative tumors (TNBC). Gold nanoparticles (AuNP; 30 nm) were modified with polyethylene glycol (PEG) chains (4 kDa) derivatized with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelators for complexing the β-emitter, (177)Lu and with PEG chains (5 kDa) linked to panitumumab for targeting BC cells expressing EGFR. The AuNP were further coated with PEG chains (2 kDa) to stabilize the particles to aggregation. The binding and internalization of EGFR-targeted AuNP ((177)Lu-T-AuNP) into BC cells was studied and compared to nontargeted (177)Lu-NT-AuNP. The cytotoxicity of (177)Lu-T-AuNP and (177)Lu-NT-AuNP was measured in clonogenic assays using BC cells with widely different EGFR densities: MDA-MB-468 (10(6) receptors/cell), MDA-MB-231 (10(5) receptors/cell), and MCF-7 cells (10(4) receptors/cell). Radiation absorbed doses to the cell nucleus of MDA-MB-468 cells were estimated based on subcellular distribution. Darkfield and fluorescence microscopy as well as radioligand binding assays revealed that (177)Lu-T-AuNP were specifically bound by BC cells dependent on their EGFR density whereas the binding and internalization of (177)Lu-NT-AuNP was significantly lower. The affinity of binding of (177)Lu-T-AuNP to MDA-MB-468 cells was reduced by 2-fold compared to (123)I-labeled panitumumab (KD = 1.3 ± 0.2 nM vs 0.7 ± 0.4 nM, respectively). The cytotoxicity of (177)Lu-T-AuNP was dependent on the amount of radioactivity incubated with BC cells, their EGFR density and the radiosensitivity of the cells. The clonogenic survival (CS) of MDA-MB-468 cells overexpressing EGFR was reduced to <0.001% at the highest amount of (177)Lu-T-AuNP tested (4.5 MBq; 6 × 10(11) AuNP per 2.5 × 10(4)-1.2 × 10(5) cells). (177)Lu-T-AuNP were less effective for killing MDA-MB-231 cells or MCF-7 cells with

  4. Acupuncture points in the book of Şerefeddin Sabuncuoğlu, a 15th century Turkish physician.

    PubMed

    Acar, H Volkan

    2015-02-01

    Şerefeddin Sabuncuoğlu (1385-1468?), the author of Cerrahiyetü'l-Haniyye (Imperial Surgery), was a distinguished Ottoman Turkish surgeon. The first illustrated Turkish surgical textbook, Cerrahiyetü'l-Haniyye consisted of three chapters (ie, cauterisation treatments, surgical procedures and fractures and dislocations). Although the main source of the book was Al-Tasrif (Textbook of Surgery) by Albucasis (Abu al-Qasim al-Zahrawi; 936-1013 AD), Sabuncuoğlu added much new information, his clinical experiences and suggestions. The original illustrations and human figures made Cerrahiyetü'l-Haniyye the first illustrated medical textbook in Turkish and Islamic medicine literature. Cerrahiyetü'l-Haniyye was also a valuable source for acupuncturists. Some new sections and additions revealed that Sabuncuoğlu had knowledge of Chinese medicine. In four sections of Cerrahiyetü'l-Haniyye (ie, toothache, haemorrhoids, eczema and dermatophytosis) Sabuncuoğlu described acupuncture techniques and point locations. It is likely that the Chinese medicine content of Cerrahiyetü'l-Haniyye was derived from Central Asian roots of Anatolian Turkish people. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  5. CW and mode-locked operation of Yb(3+)-doped Lu3Al5O12 ceramic laser.

    PubMed

    Nakao, Hiroaki; Shirakawa, Akira; Ueda, Ken-ichi; Yagi, Hideki; Yanagitani, Takagimi

    2012-07-02

    CW laser operation and first mode-locked laser operation of Yb:LuAG ceramic are reported. Efficient CW laser operation was obtained with maximum output power of 2.14 W and a 72% slope efficiency. Femtosecond mode-locked laser operation was achieved with pulse duration of 699 fs and a 200 mW average output power.

  6. Gamma-Ray Irradiation in the Early Solar System and the Conundrum of the 176Lu Decay Constant

    NASA Astrophysics Data System (ADS)

    Albarède, F. A.; Rosing, M.; Simionovici, A.; Blichert-Toft, J.; Bizzarro, M.; Scherer, E. E.

    2005-03-01

    The 176Lu decay constants inferred from well-dated terrestrial rocks and meteorites are inconsistent by 3 %. Excitation of the isomeric state (T1/2 = 3.7 h) in nebular gas and dust by gamma-rays from the nascent Sun accounts for this discrepancy.

  7. Predictors of Response to Radioligand Therapy of Metastatic Castrate-Resistant Prostate Cancer with 177Lu-PSMA-617.

    PubMed

    Ferdinandus, Justin; Eppard, Elisabeth; Gaertner, Florian C; Kürpig, Stefan; Fimmers, Rolf; Yordanova, Anna; Hauser, Stefan; Feldmann, Georg; Essler, Markus; Ahmadzadehfar, Hojjat

    2017-02-01

    Radioligand therapy (RLT) with (177)Lu-PSMA-617 (PSMA is prostate-specific membrane antigen) is a novel targeted therapy for metastatic prostate cancer. In this study, we evaluated the effect of different pretherapeutic parameters on the therapeutic response measured by prostate-specific antigen (PSA) 2 mo after RLT.

  8. Effect of Mg co-doping on cathodoluminescence properties of LuGAGG:Ce single crystalline garnet films

    NASA Astrophysics Data System (ADS)

    Schauer, P.; Lalinský, O.; Kučera, M.; Lučeničová, Z.; Hanuš, M.

    2017-10-01

    Mg2+ co-doped (LuGd)3(GaAl)5O12:Ce (LuGAGG:Ce,Mg) multicomponent single crystalline epitaxial garnet films were prepared and their cathodoluminescence (CL) and thermoluminescence (TSL) properties were studied in this paper. The films were prepared using the liquid phase epitaxy from lead-free BaO-B2O3-BaF2 flux and their scintillation properties were characterized using the 10 keV collimated e-beam. More specifically, temperature dependent CL intensity, CL emission spectra, CL decay characteristics as well as TSL emission characteristics of the mentioned films were measured. At the highest content of Mg (700 ppm), the CL decay time was as low as 28 ns and the CL afterglow was as low as 0.01% at 1 μs after the e-beam excitation cut-off, which are important parameters for electron detectors in e-beam devices. The CL temperature quenching of the studied films began above room temperature. An increase of Mg concentration to or above 280 ppm quenched the characteristic CL emission of LuGAGG:Ce,Mg. The TSL measurements show that the trap population in studied garnet samples is considerably suppressed. The LuGAGG:Ce,Mg multicomponent single crystalline epitaxial films were evaluated as the perspective fast scintillators for the electron detectors in the e-beam devices.

  9. Gamma induced atom displacements in LYSO and LuYAP crystals as used in medical imaging applications

    NASA Astrophysics Data System (ADS)

    Piñera, Ibrahin; Cruz, Carlos M.; Abreu, Yamiel; Leyva, Antonio; Van Espen, Piet; Díaz, Angelina; Cabal, Ana E.; Van Remortel, Nick

    2015-08-01

    The radiation damage, in terms of atom displacements, induced by gamma irradiation in LYSO and LuYAP crystals is presented. 44Sc, 22Na and 48V are used as gamma sources for this study. The energy of gammas from the electron-positron annihilation processes (511 keV) is also included in the study. The atom displacements distributions inside each material are calculated following the Monte Carlo assisted Classical Method introduced by the authors. This procedure also allows to study the atom displacements in-depth distributions inside each crystal. The atom displacements damage in LYSO crystals is found to be higher than in LuYAP crystals, mainly provoked by the displacements of silicon and oxygen atoms. But the difference between atom displacements produced in LYSO and LuYAP decreases when more energetic sources are used. On the other hand, the correlation between the atom displacements and energy deposition in-depth distributions is excellent. The atom displacements to energy deposition ratio is found to increases with more energetic photon sources. LYSO crystals are then more liable to the atom displacements damage than LuYAP crystals.

  10. Relativistic many-body calculation of energies, lifetimes, polarizabilities, blackbody radiative shift, and hyperfine constants in Lu2 +

    NASA Astrophysics Data System (ADS)

    Safronova, U. I.; Safronova, M. S.; Johnson, W. R.

    2016-09-01

    Energy levels of 30 low-lying states of Lu2 + and allowed electric-dipole matrix elements between these states are evaluated using a relativistic all-order method in which all single, double, and partial triple excitations of Dirac-Fock wave functions are included to all orders of perturbation theory. Matrix elements are critically evaluated for their accuracy and recommended values of the matrix elements are given together with uncertainty estimates. Line strengths, transition rates, and lifetimes of the metastable 5 d3 /2 and 5 d5 /2 states are calculated. Recommended values are given for static polarizabilities of the 6 s , 5 d , and 6 p states and tensor polarizabilities of the 5 d and 6 p3 /2 states. Uncertainties of the polarizability values are estimated in all cases. The blackbody radiation shift of the 6 s1 /2-5 d5 /2 transition frequency of the Lu2 + ion is calculated with the aid of the recommended scalar polarizabilities of the 6 s1 /2 and 5 d5 /2 states. Finally, A and B hyperfine constants are determined for states of 2+175Lu with n ≤9 . This work provides recommended values of transition matrix elements, polarizabilities, and hyperfine constants of Lu2 +, critically evaluated for accuracy, for benchmark tests of high-precision theoretical methodology and planning of future experiments.

  11. Comparison of ⁹⁰Y and ¹⁷⁷Lu measurement capability in UK and European hospitals.

    PubMed

    Fenwick, Andrew; Baker, Michaela; Ferreira, Kelley; Keightley, John

    2014-05-01

    Comparison exercises involving (90)Y and (177)Lu were performed during 2009 and 2012, respectively, to assess the measurement capability of hospitals in the UK and Europe. The results from the measurement of a typical liquid solution of (90)Y show that only 40% of participants could measure the solution to within 5% of the certificated value and that a significant -6% bias was present due to the use of non-standard geometries for the calibration of equipment. The results from the measurement of a standard liquid solution of (177)Lu show that 81% of participants could measure to within 5% of the certificated value and in fact 65% of these results were within 2% of the certificated value, showing administered activities can be far more accurately measured for (177)Lu than for (90)Y and that (177)Lu has a far smaller geometry dependence. These studies were performed to identify specific measurement issues in the user community and to identify areas where future research should be focused. In addition to this the work allows the participants to adjust measurement practice and identify key measurement issues.

  12. Theoretical description of the low-lying electronic states of LuBr located below 41,700 cm-1

    NASA Astrophysics Data System (ADS)

    Assaf, Joumana; Taher, Fadia; Magnier, Sylvie

    2017-03-01

    A theoretical investigation of the lowest molecular states of LuBr located below 41,700 cm-1 in the 2S+1Λ(+/-) and Ω(±) representations when including the spin-orbit effects, has been performed through SA-CASSCF and MRCI calculations. Potential energy curves have been determined for 21 2S+1Λ(+/-) and 42 Ω(±) molecular states in the range of 1.70 to 3.50 Å and the spectroscopic constants (Re, Te, ωe and ωeχe) have been deduced. Transition Dipole Moments have been computed for various allowed ΔΛ=0,±1 on the same range of internuclear distances. In the case of the ground state and the two expected lowest singlet excited states (1)1Π and (2)1Σ+, a good agreement with the experimental results is obtained while new results are reported for the not yet observed 18 2S+1Λ(+/-) and 42 Ω(±) states. A comparison with previous studies on the Lutetium mono-halides LuF, LuCl and LuI is presented, leading to trends in transition energies, equilibrium distances and dipole moments.

  13. Basicity properties of eigenfunctions of the periodic problem for differential operator Lu = -u″(-x) + q(x)u(x)

    NASA Astrophysics Data System (ADS)

    Sarsenbi, Abdizhahan

    2017-09-01

    In this paper, questions of the basis property of the system of eigenfunctions of the periodic problem for the operator Lu = -u″(-x) + q(x)u(x) are considered. We have constructed the Green's function of the problem under consideration. A theorem on equiconvergence is proved.

  14. Features of the band structure and conduction mechanisms of n-HfNiSn semiconductor heavily Lu-doped

    SciTech Connect

    Romaka, V. A.; Rogl, P.; Romaka, V. V.; Kaczorowski, D.; Stadnyk, Yu. V.; Korzh, R. O.; Krayovskyy, V. Ya.; Kovbasyuk, T. M.

    2015-03-15

    The crystal and electronic structures, energy, kinetic, and magnetic characteristics of n-HfNiSn semiconductor heavily doped with a Lu acceptor impurity in the ranges T = 80–400 K and N{sub A}{sup Lu} ≈ 1.9 × 10{sup 20}−1.9 × 10{sup 21} cm{sup −3} (x = 0.01–0.10) at H ≤ 10 kG is studied. The nature of the structural-defect generation mechanism leading to changes in the band gap and the degree of semiconductor compensation is determined. Its essence is the simultaneous reduction and elimination of donor-type structural defects due to the displacement of ∼1% of Ni atoms from the Hf (4a) site, the generation of acceptor-type structural defects by substituting Ni atoms with Lu atoms at the 4c site, and the generation of donor-type defects such as vacancies at the Sn (4b) site. The results of calculations of the electronic structure of Hf{sub 1−x}Lu{sub x}NiSn are in agreement with experimental data. The results are discussed within the model of a heavily doped and compensated Shklovskii-Efros semiconductor.

  15. Effects of disorder and isotopic substitution in the specific heat and Raman scattering in LuB{sub 12}

    SciTech Connect

    Sluchanko, N. E. Azarevich, A. N.; Bogach, A. V.; Vlasov, I. I.; Glushkov, V. V.; Demishev, S. V.; Maksimov, A. A.; Tartakovskii, I. I.; Filatov, E. V.; Flachbart, K.; Gabani, S.; Filippov, V. B.; Shitsevalova, N. Yu.; Moshchalkov, V. V.

    2011-09-15

    Precision measurements of the specific heat and spectral intensity I({omega}) of Raman scattering for Lu{sup N}B{sub 12} single crystal samples with various boron isotopes (N = 10, 11, nat) have been performed at low and intermediate temperatures. A boson peak in the low-frequency part of the I({omega}) spectrum has been observed for the first time for lutetium dodecaboride at liquid nitrogen temperatures. It has been shown that low-temperature anomalies in the specific heat, along with the features of Raman spectra, can be interpreted in terms of the transition to a cageglass state at T* = 50-70 K, which appears when Lu{sup 3+} ions are displaced from the centrosymmetric position in cavities of a rigid covalent boron sublattice towards the randomly located boron vacancies. The concentrations of various two-level systems that correspond to two types of vibrational clusters with correlation lengths of 12-15 and 18-22 A, respectively, have been estimated. The vibrational density of states of LuB{sub 12} has been calculated from Raman spectra in the model of soft atomic potentials. An approach has been proposed to explain the dielectrization of the properties of the YbB{sub 12} compound at T < T*, as well as the features of the formation of magnetic structures in RB{sub 12} antiferromagnets (R = Tb, Dy, Ho, Er, Tm) and the suppression of superconductivity in LuB{sub 12}.

  16. Effects of Y and Lu substitutions on the low temperature structural properties of Tb2Fe2Si2C

    NASA Astrophysics Data System (ADS)

    Susilo, R. A.; Triyono, D.

    2017-07-01

    The effects of Y and Lu substitutions on the structural properties of Tb2Fe2Si2C have been investigated by low temperature X-ray diffraction measurements. We find that the magnetoelastic transition observed in the undoped sample is shifted towards low temperature and the strength of the spontaneous magnetostriction is weakened with the increasing Y content. Substitution of Tb with 50 % of Y in Tb1.0Y1.0Fe2Si2C is almost sufficient to fully suppress the spontaneous magnetostriction observed in the undoped sample. Although substituting Tb with 5 % of Lu has the same compression effects to that of Tb with 25 % of Y, we observed no pronounced changes to the anomalies in the lattices parameters of Tb1.9Lu0.1Fe2Si2C (5 % Lu) which suggests that the suppression of the anomalies in Tb1.5Y0.5Fe2Si2C (25 % Y) is most likely due to the weakening of the long range magnetic correlations between Tb3+ ions upon dilution by a relatively high content of non-magnetic Y and is not the results of a chemical stress on the unit cell of the parent Tb2Fe2Si2C.

  17. Lattice dynamics of xenotime: The phonon dispersion relations and density of states of LuPO{sub 4}

    SciTech Connect

    Nipko, J.C.; Loong, C.; Loewenhaupt, M.; Braden, M.; Reichardt, W.; Boatner, L.A.

    1997-11-01

    LuPO{sub 4} is the nonmagnetic end member of a series of rare-earth phosphates with a common zircon-type crystal structure. The phonon-dispersion curves of LuPO{sub 4} along the [x,0,0], [x,x,0], and [0,0,x] symmetry directions were measured by neutron triple-axis spectroscopy using single-crystal samples. The phonon density of states was determined by time-of-flight neutron scattering using polycrystalline samples. Phonons involving mainly motions of rare-earth ions were found to be well separated in energy from those of the P and O vibrations. A large gap in the phonon-frequency-distribution function, which divides the O-P-O bending-type motions from the P-O stretches, was observed. All of the experimental results were satisfactorily accounted for by lattice-dynamic shell-model calculations. LuPO{sub 4} is a host material for the incorporation of rare-earth ions to produce activated luminescence. Information regarding the phonon and thermodynamic properties of LuPO{sub 4} is pertinent to extended investigations of additional rare-earth spin-lattice interactions in other zircon-structure rare-earth orthophosphates. {copyright} {ital 1997} {ital The American Physical Society}

  18. Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice

    PubMed Central

    Schüler, Emil; Larsson, Maria; Parris, Toshima Z.; Johansson, Martin E.; Helou, Khalil; Forssell-Aronsson, Eva

    2015-01-01

    The kidneys are one of the main dose-limiting organs in peptide receptor radionuclide therapy and due to large inter-individual variations in renal toxicity, biomarkers are urgently needed in order to optimize therapy and reduce renal tissue damage. The aim of this study was to investigate the transcriptional, functional, and morphological effects on renal tissue after 177Lu-octreotate administration in normal mice, and to identify biomarkers for radiation induced renal toxicity. Methods C57BL/6N mice were i.v. injected with 0, 30, 60, 90, 120, or 150 MBq 177Lu-octreotate (0, 16, 29, 40, 48, and 54 Gy to the kidneys). At 4, 8, and 12 months after administration, radiation-induced effects were evaluated in relation to (a) global transcriptional variations in kidney tissues, (b) morphological changes in the kidneys, (c) changes in white and red blood cell count as well as blood levels of urea, and (d) changes in renal function using 99mTc-DTPA/99mTc-DMSA scintigraphy. Results In general, the highest number of differentially regulated transcripts was observed at 12 months after administration. The Cdkn1a, C3, Dbp, Lcn2, and Per2 genes displayed a distinct dose-dependent regulation, with increased expression level with increasing absorbed dose. Ifng, Tnf, and Il1B were identified as primary up-stream regulators of the recurrently regulated transcripts. Furthermore, previously proposed biomarkers for kidney injury and radiation damage were also observed. The functional investigation revealed reduced excretion of 99mTc-DTPA after 150 MBq, an increased uptake of 99mTc-DMSA at all dose levels compared with the controls, and markedly increased urea level in blood after 150 MBq at 12 months. Conclusion Distinct dose-response relationships were found for several of the regulated transcripts. The Cdkn1a, Dbp, Lcn2, and Per2 genes are proposed as biomarkers for 177Lu-octreotate exposure of kidney. Correlations to functional and morphological effects further confirm

  19. Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands

    PubMed Central

    Hens, Marc; Vaidyanathan, Ganesan; Zhao, Xiao-Guang; Bigner, Darell D.; Zalutsky, Michael R.

    2010-01-01

    Introduction Monoclonal antibody (mAb) L8A4 binds specifically to the epidermal growth factor receptor variant III (EGFRvIII) that is present on gliomas but not normal tissues, and is internalized rapidly after receptor binding. Because of the short range of its β-emissions, labeling this mAb with177Lu would be an attractive approach for the treatment of residual tumor margins remaining after surgical debulking of brain tumors. Materials and Methods L8A4 mAb was labeled with 177Lu using the acyclic ligands [(R)-2-Amino-3-(4-isothiocyanatophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine- pentaacetic acid (CHX-A″-DTPA) and 2-(4-Isothiocyanatobenzyl)-6-methyldiethylene- triaminepentaacetic acid (1B4M-DTPA), and the macrocyclic ligands S-2-(4- Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-tetraacetic acid (C-DOTA) and α-(5-isothiocyanato-2-methoxyphenyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid (MeO-DOTA). Paired-label tissue distribution experiments were performed in athymic mice bearing subcutaneous EGFRvIII-expressing U87.)EGFR glioma xenografts over a period of 1 to 8 days to directly compare 177Lu-labeled L8A4 to L8A4 labeled with 125I using N-succinimidyl 4-guanidinomethyl-3-[125I]iodobenzoate ([125I]SGMIB). Results Except with C-DOTA, tumor uptake for the 177Lu-labeled mAb was significantly higher than the co-administered radioiodinated preparation; however, this was also the case for spleen, liver, bone and kidneys. Tumor:normal tissue ratios for 177Lu-1B4M-DTPA-L8A4 and to an even greater extent, 177Lu-MeO-DOTA-L8A4, were higher than those for [125I]SGMIB-L8A4 in most other tissues. Conclusions Tumor and normal tissue distribution patterns for this anti-EGFRvIII mAb were dependent on the nature of the bifunctional chelate used for 177Lu labeling. Optimal results were obtained with 1B4M-DTPA and MeO-DOTA, suggesting no clear advantage for acyclic vs. macrocyclic ligands for this application. PMID:20870149

  20. Quality evaluation of Guan-Xin-Ning injection based on fingerprint analysis and simultaneous separation and determination of seven bioactive constituents by capillary electrophoresis.

    PubMed

    Xu, Liying; Chang, Ruimiao; Chen, Meng; Li, Lou; Huang, Yayun; Zhang, Hongfen; Chen, Anjia

    2017-09-07

    The purpose of this study was to develop a comprehensive, rapid and practical capillary electrophoresis (CE) method for quality control (QC) of Guan-Xin-Ning (GXN) injection based on fingerprint analysis and simultaneous separation and determination of seven constituents. In fingerprint analysis, a capillary zone electrophoresis (CZE) method with a running buffer of 30 mM borate solution (pH 9.3) was established. Meanwhile, 10 batches of samples were used to establish the fingerprint electropherogram and 34 common peaks were obtained within 20 min. The RSD of relative migration times (RMT) and relative peak areas (RPA) were less than 5%. In order to further evaluate the quality of GXN injection, a micellar electrokinetic chromatography (MEKC) method was developed for simultaneous separation and determination of bioactive constituents. Seven components reached baseline separation with a running buffer containing 35 mM SDS and 45 mM borate solution (pH 9.3). A good linearity was obtained with correlation coefficients from 0.9906 to 0.9997. The LOD and LOQ ranged from 0.12 to 1.50 μg/mL and from 0.40 to 4.90 μg/mL, respectively. The recoveries ranged between 99.0 and 104.4%. Therefore, it was concluded that the proposed method can be used for full-scale quality analysis of GXN injection. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  1. Preclinical evaluation of (177)lu-nimotuzumab: a potential tool for radioimmunotherapy of epidermal growth factor receptor-overexpressing tumors.

    PubMed

    Vera, Denis Rolando Beckford; Eigner, Sebastian; Beran, Milos; Henke, Katerina Eigner; Laznickova, Alice; Laznicek, Milan; Melichar, Frantisek; Chinol, Marco

    2011-06-01

    The humanized monoclonal antibody Nimotuzumab (h-R3) has demonstrated an exceptional and better clinical profile than other monoclonal antibodies for immunotherapy of epidermal growth factor receptor-overexpressing tumors. This work deals with the preparation and radiolabeling optimization of (177)Lu-Nimotuzumab and their preclinical evaluation. Nimotuzumab was conjugated with S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid (p-SCN-Bn-DOTA), testing different molar ratios. The immunoconjugates were characterized. The radiolabeling with (177)Lu was optimized. Radioimmunoconjugates stability was tested in 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid (DTPA) excess and human serum. In vitro studies were performed in tumor model cell lines. Receptor-specific binding was tested by competitive inhibition. (177)Lu-Nimotuzumab in vivo studies were conducted in healthy and xenograft animals. Nimotuzumab conjugates were obtained with high purity. Radiolabeling yield and specific activities ranged from 63.6% to 94.5% and from 748 to 1142 MBq/mg, respectively. The stability in DTPA excess and human serum was 95.9% and 93.2% after 10 days, respectively. The radioimmunoconjugate showed specific receptor binding in tumor cell lines. Biodistribution in healthy animals showed the typical behavior of the immunoconjugates based on monoclonal antibodies. The study in xenografts mice demonstrated uptake of (177)Lu-Nimotuzumab in the tumor and reticuloendothelial organs. (177)Lu-Nimotuzumab was obtained with high purity and specific activities under optimal conditions without significant loss in immunoreactivity and might be a potential radioimmunoconjugate for radioimmunotherapy of tumors with epidermal growth factor receptor overexpression.

  2. Biodistribution and dosimetry results from a phase 1 trial of (177)Lu-lilotomab satetraxetan antibody-radionuclide conjugate therapy.

    PubMed

    Blakkisrud, Johan; Holtedahl, Jon Erik; Løndalen, Ayca; Dahle, Jostein; Bach-Gansmo, Tore; Holte, Harald; Nygaard, Stine; Kolstad, Arne; Stokke, Caroline

    2017-08-28

    (177)Lu-lilotomab satetraxetan is a novel antibody radionuclide conjugate (ARC) currently in a phase 1/2a first-in-human dosage escalation trial for patients with relapsed CD37+ indolent non-Hodgkin lymphoma. The aim of this study was to investigate biodistribution and absorbed doses to organs at risk. Methods: A total of seven patients treated with (177)Lu-lilotomab satetraxetan were included for dosimetry. Patients were grouped based on two different pre-dosing regimens (with and without pre-dosing with 40 mg lilotomab) and were treated with different levels of activity per body weight (10, 15 and 20 MBq/kg). All patients were pre-treated with rituximab. Serial planar and SPECT/CT-images were used to determine time activity curves and patient specific masses for organs with (177)Lu-lilotomab satetraxetan uptake. Doses were calculated with OLINDA/EXM. Results: Organs with distinct uptake of (177)Lu-lilotomab satetraxetan, in addition to red bone marrow and tumors, were liver, spleen and kidneys. Largest uptake was found in the spleen, where doses ranged from 1.54 to 3.60 mGy/MBq. The liver received 0.70 to 1.15 mGy/MBq. The kidneys received the lowest dose of the source organs investigated; 0.16 to 0.79 mGy/MBq. No statistical significant differences in soft tissue absorbed doses for the two pre-dosing regimens were found. Whole body dose ranged from 0.08 to 0.17 mGy/MBq. Conclusion: The biodistribution study for patients treated with (177)Lu-lilotomab satetraxetan revealed highest physiological uptake in liver and spleen, besides red marrow. For all dosage levels investigated, doses were found modest when compared to commonly assumed tolerance limits. Copyright © 2017 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

  3. An assessment tumor targeting ability of (177)Lu labeled cyclic CCK analogue peptide by binding with cholecystokinin receptor.

    PubMed

    Cho, Eun-Ha; Lim, Jae Cheong; Lee, So-Young; Jung, Sung-Hee

    2016-07-01

    The cholecystokinin (CCK) receptor is known as a receptor that is overexpressed in many human tumors. The present study was designed to investigate the targeting ability of cyclic CCK analogue in AR42J pancreatic cells. The CCK analogues, DOTA-K(glucose)-Gly-Trp-Nle-Asp-Phe (DOTA-glucose-CCK) and DOTA-Nle-cyclo(Glu-Trp-Nle-Asp-Phe-Lys-NH2) (DOTA-[Nle]-cCCK), were synthesized and radiolabeled with (177)Lu, and competitive binding was evaluated. The binding appearance of synthesized peptide with AR42J cells was evaluated by confocal microscopy. And bio-distribution was performed in AR42J xenografted mice. Synthesized peptides were prepared by a solid phase synthesis method, and their purity was over 98%. DOTA is the chelating agent for (177)Lu-labeling, in which the peptides were radiolabeled with (177)Lu by a high radiolabeling yield. A competitive displacement of (125)I-CCK8 on the AR42J cells revealed that the 50% inhibitory concentration value (IC50) was 12.3 nM of DOTA-glucose-CCK and 1.7 nM of DOTA-[Nle]-cCCK. Radio-labeled peptides were accumulated in AR42J tumor in vivo, and %ID/g of the tumor was 0.4 and 0.9 at 2 h p.i. It was concluded that (177)Lu-DOTA-[Nle]-cCCK has higher binding affinity than (177)Lu-DOTA-glucose-CCK and can be a potential candidate as a targeting modality for a CCK receptor over-expressing tumors. Copyright © 2016 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

  4. Therapeutic response and side effects of repeated radioligand therapy with 177Lu-PSMA-DKFZ-617 of castrate-resistant metastatic prostate cancer.

    PubMed

    Ahmadzadehfar, Hojjat; Eppard, Elisabeth; Kürpig, Stefan; Fimmers, Rolf; Yordanova, Anna; Schlenkhoff, Carl Diedrich; Gärtner, Florian; Rogenhofer, Sebastian; Essler, Markus

    2016-03-15

    Prostate-specific membrane antigen (PSMA) is highly expressed on prostate epithelial cells and strongly up-regulated in prostate cancer (PC), making it an optimal target for the treatment of metastasized PC. Radioligand therapy (RLT) with 177Lu-PSMA-DKFZ-617 (Lu-PSMA) is a targeted therapy for metastatic PC. In this study, we retrospectively analyzed the side effects and the response rate of 24 hormone and/or chemorefractory PC patients with a mean age of 75.2 years (range: 64-82) with distant metastases and progressive disease according to the PSA level, who were treated with Lu-PSMA. Median PSA was 522 ng/ml (range: 17-2360). Forty-six cycles of Lu-PSMA were performed. Of the 24 patients, 22 received two cycles. Eight weeks after the first cycle of Lu-PSMA therapy 79.1% experienced a decline in PSA level. Eight weeks after the second cycle of Lu-PSMA therapy 68.2% experienced a decline in PSA relative to the baseline value. Apart from two cases of grade 3 anemia, there was no relevant hemato- or nephrotoxicity (grade 3 or 4). These results confirmed that Lu-PSMA is a safe treatment option for metastatic PC patients and has a low toxicity profile. A positive response to therapy in terms of decline in PSA occurs in about 70% of patients.

  5. Therapeutic response and side effects of repeated radioligand therapy with 177Lu-PSMA-DKFZ-617 of castrate-resistant metastatic prostate cancer

    PubMed Central

    Ahmadzadehfar, Hojjat; Eppard, Elisabeth; Kürpig, Stefan; Fimmers, Rolf; Yordanova, Anna; Schlenkhoff, Carl Diedrich; Gärtner, Florian; Rogenhofer, Sebastian; Essler, Markus

    2016-01-01

    Prostate-specific membrane antigen (PSMA) is highly expressed on prostate epithelial cells and strongly up-regulated in prostate cancer (PC), making it an optimal target for the treatment of metastasized PC. Radioligand therapy (RLT) with 177Lu-PSMA-DKFZ-617 (Lu-PSMA) is a targeted therapy for metastatic PC. In this study, we retrospectively analyzed the side effects and the response rate of 24 hormone and/or chemorefractory PC patients with a mean age of 75.2 years (range: 64–82) with distant metastases and progressive disease according to the PSA level, who were treated with Lu-PSMA. Median PSA was 522 ng/ml (range: 17–2360). Forty-six cycles of Lu-PSMA were performed. Of the 24 patients, 22 received two cycles. Eight weeks after the first cycle of Lu-PSMA therapy 79.1% experienced a decline in PSA level. Eight weeks after the second cycle of Lu-PSMA therapy 68.2% experienced a decline in PSA relative to the baseline value. Apart from two cases of grade 3 anemia, there was no relevant hemato- or nephrotoxicity (grade 3 or 4). These results confirmed that Lu-PSMA is a safe treatment option for metastatic PC patients and has a low toxicity profile. A positive response to therapy in terms of decline in PSA occurs in about 70% of patients. PMID:26871285

  6. Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell alpha4beta1 integrin: role in adhesion of sickle red blood cells to endothelial cells.

    PubMed

    El Nemer, Wassim; Wautier, Marie-Paule; Rahuel, Cécile; Gane, Pierre; Hermand, Patricia; Galactéros, Frédéric; Wautier, Jean-Luc; Cartron, Jean-Pierre; Colin, Yves; Le Van Kim, Caroline

    2007-04-15

    The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. In addition to red blood cells, Lu/BCAM proteins are highly expressed in endothelial cells. Abnormal adhesion of red blood cells to the endothelium could potentially contribute to the vaso-occlusive episodes in sickle cell disease. Considering the presence of integrin consensus-binding sites in Lu/BCAM proteins, we investigated their potential interaction with integrin alpha(4)beta(1), the unique integrin expressed on immature circulating sickle red cells. Using cell adhesion assays under static and flow conditions, we demonstrated that integrin alpha(4)beta(1) expressed on transfected cells bound to chimeric Lu-Fc protein. We showed that epinephrine-stimulated sickle cells, but not control red cells, adhered to Lu-Fc via integrin alpha(4)beta(1) under flow conditions. Antibody-mediated activation of integrin alpha(4)beta(1) induced adhesion of sickle red cells to primary human umbilical vein endothelial cells; this adhesion was inhibited by soluble Lu-Fc and vascular cell adhesion molecule-1 (VCAM-1)-Fc proteins. This novel interaction between integrin alpha(4)beta(1) in sickle red cells and endothelial Lu/BCAM proteins could participate in sickle cell adhesion to endothelium and potentially play a role in vaso-occlusive episodes.

  7. Indirect Production of No Carrier Added (NCA) (177)Lu from Irradiation of Enriched (176)Yb: Options for Ytterbium/Lutetium Separation.

    PubMed

    Dash, Ashutosh; Chakravarty, Rubel; Knapp, Furn F Russ; Pillai, Ambikalmajan M R

    2015-01-01

    This article presents a concise review of the production of no-carrier-added (NCA) (177)Lu by the 'indirect' route by irradiating ytterbium-176 ((176)Yb)-enriched targets. The success of this production method depends on the ability to separate the microscopic amounts of NCA (177)Lu from bulk irradiated ytterbium targets. The presence of Yb(+3) from the target in the final processed (177)Lu will adversely affect the quality of (177)Lu by decreasing the specific activity and competing with Lu(+3) complexation since ytterbium will follow the same coordination chemistry. Ytterbium and lutetium are adjacent members of the lanthanide family with very similar chemical properties which makes the separation of one from the other a challenging task. This review provides a summary of the methods developed for the separation and purification of NCA (177)Lu from neutron irradiated (176)Yb-enriched targets, a critical assessment of recent developments and a discussion of the current status of this (177)Lu production method.

  8. Three-dimensional calculation of supersonic reacting flows using an LU scheme

    NASA Astrophysics Data System (ADS)

    Yu, Sheng-Tao; Tsai, Y.-L. Peter; Shuen, Jian-Shun

    1989-01-01

    A new three-dimensional numerical program incorporated with comprehensive real gas property models has been developed to simulate supersonic reacting flows. The code employs an implicit finite volume, Lower-Upper (LU) time-marching method to solve the complete Navier-Stokes and species equations in a fully-coupled and very efficient manner. A chemistry model with nine species and eighteen reaction steps are adopted in the program to represent the chemical reaction of H2 and air. To demonstrate the capability of the program, flow fields of underexpanded hydrogen jets transversely injected into supersonic air stream inside the combustors of scramjets are calculated. Results clearly depict the flow characteristics, including the shock structure, separated flow regions around the injector, and the distribution of the combustion products.

  9. Effect of amplified spontaneous emission on selectivity of laser photoionisation of the 177Lu radioisotope

    NASA Astrophysics Data System (ADS)

    D'yachkov, A. B.; Gorkunov, A. A.; Labozin, A. V.; Mironov, S. M.; Panchenko, V. Ya; Firsov, V. A.; Tsvetkov, G. O.

    2016-06-01

    A significant deselecting effect of amplified spontaneous emission has been observed in the experiments on selective laser photoionisation of the 177Lu radioisotope according to the scheme 5d6s2 2D3/2 → 5d6s6p 4Fo5/2 (18505 cm-1) → 5d6s7s 4D3/2(37194 cm-1) → autoionisation state (53375 cm-1). The effect is conditioned by involvement of non-target isotopes from the lower metastable level 5d6s2 2D5/2(1994 cm-1) into the ionisation process. Spectral filtering of spontaneous emission has allowed us to significantly increase the selectivity of the photoionisation process of the radioisotope and to attain a selectivity value of 105 when using saturating light intensities.

  10. Anomalous charge transport in RB12 (R = Ho, Er, Tm, Lu)

    NASA Astrophysics Data System (ADS)

    Sluchanko, N.; Bogomolov, L.; Glushkov, V.; Demishev, S.; Ignatov, M.; Khayrullin, Eu.; Samarin, N.; Sluchanko, D.; Levchenko, A.; Shitsevalova, N.; Flachbart, K.

    High precision measurements of Hall RH(T) and Seebeck S(T) coefficients have been carried out for the first time on single crystals of rare earth dodecaborides RB12 (R D Ho, Er, Tm, Lu) at temperatures 1.8-300 K. Low temperature anomalies detected on the temperature dependencies of RH(T) and S(T) are associated with antiferromagnetic phase transitions in HoB12, ErB12 and TmB12 compounds. The observed discrepancy between the change of charge carriers' mobility and de-Gennes factor (g - 1)2 J(J + 1) (J - angular momentum of the 4f shell) in the set of HoB12-TmB12 allows us to conclude about the appreciable influence of spin fluctuations on the charge transport in these compounds with B12 atomic clusters.

  11. 57Fe Mössbauer study of Lu2Fe3Si5 iron silicide superconductor

    DOE PAGES

    Ma, Xiaoming; Ran, Sheng; Pang, Hua; ...

    2015-03-28

    With the advent of Fe–As based superconductivity it has become important to study how superconductivity manifests itself in details of 57Fe Mössbauer spectroscopy of conventional, Fe-bearing superconductors. The iron-based superconductor Lu2Fe3Si5 has been studied by 57Fe Mössbauer spectroscopy over the temperature range from 4.4 K to room temperature with particular attention to the region close to the superconducting transition temperature (Tc=6.1 K). Consistent with the two crystallographic sites for Fe in this structure, the observed spectra appear to have a pattern consisting of two doublets over the whole temperature range. Furthermore, the value of Debye temperature was estimated from temperaturemore » dependence of the isomer shift and the total spectral area and compared with the specific heat capacity data. Neither abnormal behavior of the hyperfine parameters at or near Tc, nor phonon softening were observed.« less

  12. Low threshold monocrystalline Nd:(Gd, Lu)2O3 channel waveguide laser.

    PubMed

    Kahn, Andreas; Heinrich, Sebastian; Kühn, Henning; Petermann, Klaus; Bradley, Jonathan D B; Wörhoff, Kerstin; Pollnau, Markus; Huber, Günter

    2009-03-16

    We report the first waveguide laser based on a rare-earth-doped sesquioxide. A 2 microm thick lattice matched Nd(0.5%):(Gd, Lu)(2)O(3) film with a nearly atomically flat surface has been epitaxially grown on a Y(2)O(3) substrate, using pulsed laser deposition. The film has been structured with reactive ion etching and a rib channel waveguide laser has been realized. Laser radiation at 1075 nm and 1079 nm has been observed under 820-nm pumping. The laser possesses a threshold power of about 0.8 mW and a preliminary slope efficiency of 0.5% versus incident pump power. A maximum output power of 1.8 mW has been obtained for 370 mW incident pump power.

  13. Thermoelectric properties of binary LnN (Ln=La and Lu): First principles study

    SciTech Connect

    Sreeparvathy, P. C.; Gudelli, Vijay Kumar; Kanchana, V.; Vaitheeswaran, G.; Svane, A.; Christensen, N. E.

    2015-06-24

    First principles density functional calculations were carried out to study the electronic structure and thermoelectric properties of LnN (Ln = La and Lu) using the full potential linearized augmented plane wave (FP-LAPW) method. The thermoelectric properties were calculated by solving the Boltzmann transport equation within the constant relaxation time approximation. The obtained lattice parameters are in good agreement with the available experimental and other theoretical results. The calculated band gaps using the Tran-Blaha modified Becke-Johnson potential (TB-mBJ), of both compounds are in good agreement with the available experimental values. Thermoelectric properties like thermopower (S), electrical conductivity scaled by relaxation time (σ/τ) and power-factor (S{sup 2}σ/τ) are calculated as functions of the carrier concentration and temperature for both compounds. The calculated thermoelectric properties are compared with the available experimental results of the similar material ScN.

  14. Properties of Tb-doped vacuum-sintered Lu2O3 storage phosphor

    NASA Astrophysics Data System (ADS)

    Zych, E.; Trojan-Piegza, J.; Hreniak, D.; Strek, W.

    2003-08-01

    Tb3+-doped Lu2O3 sintered ceramics were prepared in vacuum and in air. It was shown that the vacuum-sintered disks are able to store energy when irradiated with 300-nm or shorter photons. A small part of the stored energy could be recovered with 980-nm light. A much more significant amount of the stored energy could be released with red 647-nm photons. However, recovering the total stored energy could be accomplished only upon heating up to about 300 °C. Changes in absorption of the raw materials upon ultraviolet irradiation and subsequent IR (980 and 647 nm) treatments or upon heating at 300 °C are presented and discussed. A model for energy storing and recovering through the various IR irradiations or through heating is presented. At least two distinct ways of hole trapping as Tb4+ or Vk-center as well as creation of F and F+ is suggested.

  15. Efficient passively Q-switched miniature Yb:Lu3Ga5O12 crystal laser

    NASA Astrophysics Data System (ADS)

    Han, Wenjuan; Chen, Xiaowen; Xia, Linhua; Wu, Kui; Zhang, Huaijin; Wang, Shiwu; Liu, Junhai

    2015-08-01

    A passively Q-switched miniature Yb:Lu3Ga5O12 crystal laser is demonstrated under 935-nm diode pumping, producing an average output power of 3.21 W at 1035 nm at a pulse repetition frequency of 26.3 kHz, with optical-to-optical and slope efficiencies being 36.5% and 60%, respectively. With the output coupling being increased and the initial transmission of the saturable absorber being lowered, an output power of 1.61 W at 1026 nm is generated at 8.3 kHz, the resulting pulse energy, duration and peak power were respectively 194 μJ, 2.5 ns and 77.6 kW.

  16. Dual-wavelength passively mode-locked Nd:LuYSiO5 laser with SESAM.

    PubMed

    Cong, Zhenhua; Tang, Dingyuan; De Tan, Wei; Zhang, Jian; Xu, Changwen; Luo, Dewei; Xu, Xiaodong; Li, Dongzhen; Xu, Jun; Zhang, Xingyu; Wang, Qingpu

    2011-02-28

    A diode-end-pumped dual-wavelength mode-locked laser based on Nd:LuYSiO5 crystal is demonstrated. With a SESAM, simultaneous mode locking at the 1075.8 nm and 1078.1 nm is achieved and the dual-wavelength mode locked pulses have a pulse width of 8.9 ps. Due to frequency beating, ultrahigh repetition rate ultrafast pulses with 997 fs pulse width and 0.59 THz repetition rate are further formed. Under 12.7 W absorbed pump power 1.7 W mode-locked output power was obtained, the slope efficiency of the mode locked laser was 24.3%.

  17. Use of (177)Lu-dotatate in the treatment of iodine refractory thyroid carcinomas.

    PubMed

    Oliván-Sasot, P; Falgás-Lacueva, M; García-Sánchez, J; Vera-Pinto, V; Olivas-Arroyo, C; Bello-Arques, P

    In a patient with a differentiated thyroid cancer the standard treatment protocol to be followed is surgery, ablation of thyroid remnants with (131)Iodine ((131)I), and TSH suppression. However, the treatment with (131)I is not effective in some cases, and it no longer becomes a therapeutic option due to cell de-differentiation with loss of (131)I uptake. Systemic treatment can be used as other options, although patients are not always responsive; thus, the disease may progress and therapeutic options may run out. Endocrine tumours may express somatostatin receptors,and this characteristic has been used, not only for diagnosis, but also for their treatment through somatostatin analogue labelling with radioactive isotopes. This was the case of a patient suffering from iodine-refractory follicular thyroid carcinoma, with somatostatin receptors expression, treated with (177)Lu-DOTATATE, showing an excellent clinical and analytical response.

  18. Scintillation characterizations of Tl 2 LiLuCl 6 : Ce 3+ single crystal

    NASA Astrophysics Data System (ADS)

    Rooh, Gul; Kim, H. J.; Jang, Jonghun; Kim, Sunghwan

    2017-07-01

    0.5%, 1%, 3% and 5% Ce-concentration single crystals of Tl2LiLuCl6 were grown from the melt using two zone vertical Bridgman technique. X-ray induced emission spectra showed Ce3+ emission between 370 nm and 540 nm wavelength range. Energy resolution, light yield and decay time of the grown samples were measured under {\\gamma}-ray excitation at room temperature. Energy resolution of 5.6% (FWHM) with 27,000+-2700 light yield is found for 1%Ce doped sample. For the same dopant concentration, three decay time components are also observed. Variation of scintillation properties is observed as a function of dopant concentration in this material.This material will provide excellent detection efficiency for X- and {\\gamma}-rays due to its high effective Z-number and density. It is expected that this scintillor will be a potential detector for the medical imaging techniques.

  19. Electro-optically cavity-dumped 3  ns Tm:LuAG laser.

    PubMed

    Zhang, Ye; Yao, Baoquan; Dai, Tongyu; Shi, Hongwei; Han, Liu; Shen, Yingjie; Ju, Youlun

    2016-04-10

    It is reported in this paper that a cavity-dumped electro-optically Q-switched Tm:LuAG oscillator offers a unique combination of high power, constant short pulse duration, and high repetition rate at a wavelength of 2012.7 nm. The constant short pulse durations of 3 ns were achieved by the cavity-dumped technology at different repetition rates from 60 to 100 kHz. An average power of 1.22 W and a peak power of 4.1 kW were obtained at a repetition rate of 100 kHz and an incident pump power of 42.3 W, corresponding to the slope efficiency of 6% and beam quality factor of M2∼1.4. In addition, the accumulation time of intracavity photons from 500 to 1000 ns was studied for the performance of the output characteristic.

  20. Charge Order, Dynamics, and Magnetostructural Transition in Multiferroic LuFe2O4

    SciTech Connect

    Xu, S. U.; Angst, Manuel; Brinzari, T. V.; Hermann, Raphael P.; Musfeldt, J. L.; Christianson, Andrew D; Mandrus, David; Mcgill, S.; Kim, J.-W.; Islam, Z.

    2008-01-01

    The cascade of temperature and field-driven transitions in LuFe<2/>O<4/> was investigated byM Nossbauer and optical spectroscopies, magnetization, and x-ray scattering. A correlation of Fe2+ Fe3+ charge transfer excitations with the 320 K phase transition below which uperstructure reflections appear confirms its association with gradual charge carrier freezing. Fe2+ on-site excitations are sensitive to the 175 K magnetic transition, which Bragg splitting and large magneto optical contrast suggest involes a monoclinic distortion that can be driven by both temperature and magnetic field. PACS numbers: 71.30.+h,75.30.Kz,78.20.Ci,76.70.+y

  1. Targeted Radionuclide Therapy with A 177Lu-labeled Anti-HER2 Nanobody

    PubMed Central

    D'Huyvetter, Matthias; Vincke, Cécile; Xavier, Catarina; Aerts, An; Impens, Nathalie; Baatout, Sarah; De Raeve, Hendrik; Muyldermans, Serge; Caveliers, Vicky; Devoogdt, Nick; Lahoutte, Tony

    2014-01-01

    RIT has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. Smaller radiolabeled antibody fragments and peptides feature highly specific target accumulation, resulting in low accumulation in healthy tissue, except for the kidneys. Nanobodies are the smallest (MW < 15 kDa) functional antigen-binding fragments that are derived from heavy chain-only camelid antibodies. Here, we show that the extend of kidney retention of nanobodies is predominantly dictated by the number of polar residues in the C-terminal amino acid tag. Three nanobodies were produced with different C-terminal amino-acid tag sequences (Myc-His-tagged, His-tagged, and untagged). Dynamic planar imaging of Wistar rats with 111In-DTPA-nanobodies revealed that untagged nanobodies showed a 70 % drop in kidney accumulation compared to Myc-His-tagged nanobodies at 50 min p.i.. In addition, coinfusion of untagged nanobodies with the plasma expander Gelofusin led to a final reduction of 90 %. Similar findings were obtained with different 177Lu-DTPA-2Rs15d nanobody constructs in HER2pos tumor xenografted mice at 1 h p.i.. Kidney accumulation decreased 88 % when comparing Myc-His-tagged to untagged 2Rs15d nanobody, and 95 % with a coinfusion of Gelofusin, without affecting the tumor targeting capacity. Consequently, we identified a generic method to reduce kidney retention of radiolabeled nanobodies. Dosimetry calculations of Gelofusin-coinfused, untagged 177Lu-DTPA-2Rs15d revealed a dose of 0.90 Gy/MBq that was delivered to both tumor and kidneys and extremely low doses to healthy tissues. In a comparative study, 177Lu-DTPA-Trastuzumab supplied 6 times more radiation to the tumor than untagged 177Lu-DTPA-2Rs15d, but concomitantly also a 155, 34, 80, 26 and 4180 fold higher radioactivity burden to lung, liver, spleen, bone and blood. Most importantly, nanobody-based targeted radionuclide

  2. Electronic structure and linear magnetoresistance of the gapless topological insulator PtLuSb

    SciTech Connect

    Shekhar, Chandra; Fecher, Gerhard H.; Kumar Nayak, Ajaya; Felser, Claudia; Ouardi, Siham; Ikenaga, Eiji

    2012-06-18

    The present work reports on the experimental investigation of electronic structure and transport properties of the proposed topological insulator PtLuSb. The electronic structure was investigated by means of polarization dependent hard x-ray photoelectron spectroscopy. The valence band spectra exhibit a linear behavior close to the Fermi energy, as is typical for massless electrons. The transport properties are similar to that of a gapless semiconductor with low carrier concentration. This compound also exhibits an exceptionally high Hall mobility. At low temperatures, the magnetoresistance changes linearly with the applied magnetic field, whereas it exhibits a quadratic nature at high temperatures. A tentative relation between linear magnetoresistance and high mobility is discussed.

  3. Targeted radionuclide therapy with A 177Lu-labeled anti-HER2 nanobody.

    PubMed

    D'Huyvetter, Matthias; Vincke, Cécile; Xavier, Catarina; Aerts, An; Impens, Nathalie; Baatout, Sarah; De Raeve, Hendrik; Muyldermans, Serge; Caveliers, Vicky; Devoogdt, Nick; Lahoutte, Tony

    2014-01-01

    RIT has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. Smaller radiolabeled antibody fragments and peptides feature highly specific target accumulation, resulting in low accumulation in healthy tissue, except for the kidneys. Nanobodies are the smallest (MW<15 kDa) functional antigen-binding fragments that are derived from heavy chain-only camelid antibodies. Here, we show that the extend of kidney retention of nanobodies is predominantly dictated by the number of polar residues in the C-terminal amino acid tag. Three nanobodies were produced with different C-terminal amino-acid tag sequences (Myc-His-tagged, His-tagged, and untagged). Dynamic planar imaging of Wistar rats with 111In-DTPA-nanobodies revealed that untagged nanobodies showed a 70% drop in kidney accumulation compared to Myc-His-tagged nanobodies at 50 min p.i.. In addition, coinfusion of untagged nanobodies with the plasma expander Gelofusin led to a final reduction of 90%. Similar findings were obtained with different 177Lu-DTPA-2Rs15d nanobody constructs in HER2pos tumor xenografted mice at 1 h p.i.. Kidney accumulation decreased 88% when comparing Myc-His-tagged to untagged 2Rs15d nanobody, and 95% with a coinfusion of Gelofusin, without affecting the tumor targeting capacity. Consequently, we identified a generic method to reduce kidney retention of radiolabeled nanobodies. Dosimetry calculations of Gelofusin-coinfused, untagged 177Lu-DTPA-2Rs15d revealed a dose of 0.90 Gy/MBq that was delivered to both tumor and kidneys and extremely low doses to healthy tissues. In a comparative study, 177Lu-DTPA-Trastuzumab supplied 6 times more radiation to the tumor than untagged 177Lu-DTPA-2Rs15d, but concomitantly also a 155, 34, 80, 26 and 4180 fold higher radioactivity burden to lung, liver, spleen, bone and blood. Most importantly, nanobody-based targeted radionuclide therapy

  4. Aminocarboxylate complexes and octreotide complexes with no carrier added 177Lu, 166Ho and 149Pm.

    PubMed

    Li, Wen Ping; Smith, C Jeff; Cutler, Cathy S; Hoffman, Timothy J; Ketring, Alan R; Jurisson, Silvia S

    2003-04-01

    Several aminocarboxylate complexes of the "no carrier added" (NCA) radiolanthanides (149)Pm, (166)Ho and (177)Lu were evaluated using our in vitro hydroxyapatite and serum stability model and in vivo in normal CF-1 mice [10]. The aminocarboxylate chelates evaluated with the NCA radiolanthanides for in vitro stability were EDTA, CDTA, DTPA, MA-DTPA and DOTA. In addition, the NCA radiolanthanide complexes with DTPA-octreotide (DTPA-OCT) were synthesized and evaluated, as a model for a peptide conjugated aminocarboxylate complex. The biodistribution studies of the NCA complexes with DTPA, DOTA and DTPA-OCT showed that the in vitro model correctly predicted the in vivo stability of the radiolanthanide complexes, with Ln-DOTA > Ln-DTPA > Ln-DTPA-OCT.

  5. Grain size effect on magnetic and electric properties of LuMnO3 nanocrystalline materials

    NASA Astrophysics Data System (ADS)

    Han, Tai-Chun; Chen, Jia-Wern; Liu, Yuan-Hsun; Hu, Yu-Min

    2013-05-01

    Magnetic and electric properties are investigated for the nanosized LuMnO3 samples with different grain sizes (30 nm to 500 nm) synthesized by a modified Pechini method. It shows that magnetic and electric properties are strongly dependent on the grain size. The magnetic characterization indicates that with increasing grain size, the antiferromagnetic (AFM) transition temperature increases from 72 to 89 K. The temperature-dependent dielectric measurements show an anomaly in the dielectric constant at temperatures close to the AFM ordering temperature for all samples. A corresponding shift of the peak-positions of dielectric anomaly and magnetic ordering indicates a strong correlation between the magnetic ordering and the electric polarization. Further analysis suggests that the rising of AFM transition temperature with increasing grain size should be from the structural origin, in which the strength of AFM interaction as well as the electrical polarization is dependent on the in-plane lattice parameters.

  6. Composition and species evolution in a laser-induced LuMnO3 plasma

    NASA Astrophysics Data System (ADS)

    Bator, Matthias; Hu, Yi; Esposito, Martin; Schneider, Christof W.; Lippert, Thomas; Wokaun, Alexander

    2012-09-01

    Pulsed laser deposition is often used to grow multi-elemental thin films from stoichiometric targets. The growth process is influenced by a wide variety of parameters like the target composition, background gases, laser wavelength, laser fluence, or spot size. The changes these parameters induce in the film growth also affect the plasma plume and species formed during laser ablation. For oxide growth O2, and sometimes N2O, is utilized as background gas to achieve the required oxygen composition for the as-grown film. Mass spectrometry combined with time- and space resolved emission spectroscopy is used to investigate the behavior and evolution of plasma species in the plasma plume during the ablation process of LuMnO3 dependent on the background gas.

  7. Femtosecond Spectroscopy of Electron-Lattice Coupling in LuMnO3

    NASA Astrophysics Data System (ADS)

    Lou, Shitao

    2005-03-01

    Hexagonal manganite LuMnO3 is a ferroelectric (Tc 900 K) and strongly frustrated antiferromagnetic (TN 90 K) crystal. Strong coupling between lattice, electronic, and magnetic degrees of freedom make it a promissing electronic material. We have used femtosecond pump-probe spectroscopy to observe the interaction of electron excitation and lattice vibration in real time. Optical excitation at a sharp absorption peak at 800 nm corresponding to a Mn d(x^2-y^2),(xy)->d(3z^2-r^2)transition served as the primary excitation step. Reflectivity changes as a function of delay time reveal electronic relaxation and coherent oscillations of several optical phonon modes. Electron and phonon excitation and relaxation dynamics were studied using different polarization geometries and symmetry analysis. The interaction mechanisms of photons, electrons, and coherent phonons are discussed.

  8. Exchange Interaction Effects on the Optical Properties of LuMnO3

    NASA Astrophysics Data System (ADS)

    Souchkov, A. B.; Simpson, J. R.; Quijada, M.; Ishibashi, H.; Hur, N.; Ahn, J. S.; Cheong, S. W.; Millis, A. J.; Drew, H. D.

    2003-07-01

    We have measured the optical conductivity of single crystal LuMnO3 from 10 to 45 000 cm-1 at temperatures between 4 and 300K. A symmetry allowed on-site Mn d-d transition near 1.7eV is observed to blueshift (˜0.1 eV) in the antiferromagnetic state due to Mn Mn superexchange interactions. Similar anomalies are observed in the temperature dependence of the TO phonon frequencies which arise from spin-phonon interaction. We find that the known anomaly in the temperature dependence of the quasistatic dielectric constant ɛ0 below TN˜90 K is overwhelmingly dominated by the phonon contributions.

  9. Exchange interaction effects on the optical properties of LuMnO3.

    PubMed

    Souchkov, A B; Simpson, J R; Quijada, M; Ishibashi, H; Hur, N; Ahn, J S; Cheong, S W; Millis, A J; Drew, H D

    2003-07-11

    We have measured the optical conductivity of single crystal LuMnO3 from 10 to 45000 cm(-1) at temperatures between 4 and 300 K. A symmetry allowed on-site Mn d-d transition near 1.7 eV is observed to blueshift ( approximately 0.1 eV) in the antiferromagnetic state due to Mn-Mn superexchange interactions. Similar anomalies are observed in the temperature dependence of the TO phonon frequencies which arise from spin-phonon interaction. We find that the known anomaly in the temperature dependence of the quasistatic dielectric constant epsilon(0) below T(N) approximately 90 K is overwhelmingly dominated by the phonon contributions.

  10. Oxygen displacements and magnetoelectric coupling in LuMnO3

    NASA Astrophysics Data System (ADS)

    Tong, P.; Louca, Despina; Lee, Nara; Cheong, S.-W.

    2012-09-01

    The hexagonal multiferroic LuMnO3 transforms to the P63cm symmetry upon entering the ferroelectric phase. Using neutron diffraction and the pair density function analysis, it is shown that short-range local atomic distortions are present, calling for a lower symmetry, such as the P63, for the following reasons. With cooling, the MnO5 bipyramid tilting becomes more enhanced than previously determined. This splits the in-plane Mn-O-Mn angles especially below TN, leading to inequivalent magnetic coupling constants J between the in-plane Mn ions. Additionally, below TN, several weak incommensurate magnetic phases appear in response to the reminiscent frustration from the triangular Mn lattice. The complex magnetic structure may be the driving mechanism for the lower crystal symmetry.

  11. Anomalous Phonon Behavior in Orthorhombic LuMnO3 at Low Temperature

    NASA Astrophysics Data System (ADS)

    Gao, Peng; Chen, Haiyan; Tyson, Trevor A.; Liu, Zhenxian; Bai, Jianming; Wang, Liping; Choi, Youngjai; Cheong, Sang-Wook

    2011-03-01

    We present the pressure dependent phonon spectra of orthorhombic-LuMnO3 which are conducted in the low temperature region (below TN and TL) . A temperature dependent anomalous phonon coincides with the ferroelectric behavior at low pressure condition. At ~ 10 GPa, this anomalous phonon exhibits an unusual softening trend which will be suppressed at higher pressure. This work is supported by DOE Grant DE-FG02-07ER46402 (NJIT), by DE-FG02-07ER46402 (Rutgers), by COMPRES (U2A beam line at NSLS), the Consortium for Materials Properties Research in Earth Sciences under NSF Cooperative Agreement EAR01-35554, U.S. Department of Energy (DOE-BES and NNSA/CDAC) and by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886 (use of NSLS at Brookhaven National Laboratory).

  12. Assessment of cell death mechanisms triggered by (177)Lu-anti-CD20 in lymphoma cells.

    PubMed

    Azorín-Vega, E; Rojas-Calderón, E; Martínez-Ventura, B; Ramos-Bernal, J; Serrano-Espinoza, L; Jiménez-Mancilla, N; Ordaz-Rosado, D; Ferro-Flores, G

    2017-04-12

    The aim of this research was to evaluate the cell cycle redistribution and activation of early and late apoptotic pathways in lymphoma cells after treatment with (177)Lu-anti-CD20. Experimental and computer models were used to calculate the radiation absorbed dose to cancer cell nuclei. The computer model (Monte Carlo, PENELOPE) consisted of twenty spheres representing cells with an inner sphere (cell nucleus) embedded in culture media. Radiation emissions of the radiopharmaceutical located in cell membranes and in culture media were considered for nuclei dose calculations. Flow cytometric analyses demonstrated that doses as low as 4.8Gy are enough to induce cell cycle arrest and activate late apoptotic pathways. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Constraints on Lu-Hf and Nb-Ta systematics in globally subducted oceanic crust from a survey of orogenic eclogites and amphibolites

    NASA Astrophysics Data System (ADS)

    Zirakparvar, N. Alex

    2016-04-01

    To further understand Lu-Hf and Nb-Ta systematics in globally subducted oceanic crust, this paper evaluates all available Lu-Hf garnet isochron ages and initial ɛHf values in conjunction with present-day bulk-rock Lu-Hf isotope and trace element (K, Nb, Ta, Zr, and Ti in addition to Lu-Hf) data from the world's orogenic eclogites and amphibolites (OEAs). Approximately half of OEAs exhibit Lu-Hf and Nb-Ta systematics mimicking those of unsubducted oceanic crust whereas the rest exhibit variability in one or both systems. For the Lu-Hf system, mixing calculations demonstrate that subduction-related phase transformations, in conjunction with open system behavior, can shift subducted oceanic crust toward higher Lu/Hf, or toward lower Lu/Hf that can also be associated with unradiogenic ɛHf values. However, evaluation of potential mechanisms for fractionating Nb from Ta is more complicated because many of the OEAs have Nb-Ta systematics that are decoupled from Lu-Hf and the behavior of K, Zr, and Ti. Nonetheless, the global data set demonstrates that the association between unradiogenic ɛHf and elevated Nb/Ta observed in some kimberlitic eclogite xenoliths can be inherited from processes that occurred during subduction of their oceanic crustal protoliths. This allows for a geologically based estimate of the Nb concentration in a reservoir composed of deeply subducted oceanic crust. However, mass balance calculations confirm that such a reservoir, when considered as a whole, likely has a Nb concentration similar to unsubducted oceanic crust and is therefore not the solution to the problem of the Earth's "missing" Nb.

  14. Sub-10 nm lanthanide doped BaLuF{sub 5} nanocrystals: Shape controllable synthesis, tunable multicolor emission and enhanced near-infrared upconversion luminescence

    SciTech Connect

    Rao, Ling; Lu, Wei; Wang, Haibo; Yi, Zhigao; Zeng, Songjun; Li, Zheng

    2015-04-15

    Highlights: • Sub-10 nm cubic phase BaLuF{sub 5} nanocrystals were synthesized by a hydrothermal method for the first time. • Tunable multicolor from yellow to yellow-green was achieved by controlling Gd{sup 3+} content in BaLuF{sub 5}:Yb/Er system. • Intense near-infrared upconversion luminescence in BaLuF{sub 5}:Gd/Yb/Tm nanocrystal. • The enhancement near-infrared luminescence can be realized by adjusting the content of Gd{sup 3+} in BaLuF{sub 5}:Gd/Yb/Tm system. - Abstract: In this study, sub-10 nm BaLuF{sub 5} nanocrystals with cubic phase structure were synthesized by a solvothermal method using oleic acid as the stabilizing agent. The as-prepared BaLuF{sub 5} nanocrystals were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), and analyzed by the upconversion (UC) spectra. The TEM results reveal that these samples present high uniformity. Compared with Gd-free samples, the size of BaLuF{sub 5}:Yb/Er doped with 10% Gd{sup 3+} decreased to 5.6 nm. In addition, BaLuF{sub 5}:Yb/Tm/Gd upconversion nanoparticles (UCNPs) presented efficient near-infrared (NIR)-NIR UC luminescence. Therefore, it is expected that these ultra-small BaLuF{sub 5} nanocrystals with well-controlled shape, size, and UC emission have potential applications in biomedical imaging fields.

  15. [Thermoluminescence characteristics of Lu2SiO5 : Ce phosphors].

    PubMed

    Wu, Fei; Liu, Xiao-lin; Gu, Mu; Ni, Chen; Huang, Shi-ming; Liu, Bo

    2012-02-01

    To investigate the origin of the thermoluminescence at high temperature, Lu2SiO5 : Ce0.006 (LSO : Ce) phosphors were prepared by sol-gel chemistry in air and graphite respectively. The patterns of X-ray diffraction, excitation and emission spectra and thermoluminescence curves of these samples were analyzed. In comparison with the phosphors prepared in the air, the luminescence intensity was improved and the thermoluminescence peak at 598 K was restrained for the sample prepared in graphite. It was found that the thermoluminescence peak at 598 K was relevant to Ce4+. In order to achieve more evidences, LSO : Ce0.006, K(x) (x = 0.01-0.08) phosphors were prepared. The structures and spectra of K(+) -codoped samples were also studied. By codoping with K+ ions, the luminescence intensity of LSO : Ce phosphor could be enhanced distinctly, but the crystallinity was not improved. The results of the K(+) -codoped LSO: Ce exhibited that K(+) -codoping could improve the concentration of oxygen vacancy and restrain the peak at 598 K. When K+ ion occupied the position of Lu3+, more oxygen vacancies could be created and Ce4+ turned into Ce3+ simultaneously due to the balance of electric charge, which was consistent with the result of the thermoluminescence. So it can also come to the conclusion that the thermoluminescence peak at 598 K was relevant to Ce4+. The reason for K+ ions enhancing the intensity of LSO : Ce can be attributed to the improvement of concentration ratio for Ce3+/Ce4+.

  16. Strengths and limitations of zircon Lu-Hf and O isotopes in modelling crustal growth

    NASA Astrophysics Data System (ADS)

    Payne, Justin L.; McInerney, David J.; Barovich, Karin M.; Kirkland, Christopher L.; Pearson, Norman J.; Hand, Martin

    2016-04-01

    The robust nature of the mineral zircon, combined with our analytical ability to readily acquire in-situ uranium-lead (U-Pb), lutetium-hafnium (Lu-Hf) and oxygen (O) isotopic data, has resulted in a rapid rise in the use of zircon isotopic datasets for studying both the generation of continental crust and its growth through Earth history. In such studies there has been a strong focus on developing methods to determine the timing and/or proportion of juvenile magmatic addition to the continental crust. One widespread approach to determine the timing of crustal growth has been the construction or fitting of 'reworking arrays' to regional Hf isotopic datasets. Simple stochastic models are presented which highlight that in many cases apparent reworking arrays are much more likely to represent a process of on-going dilution and refertilisation of ancient crust, consistent with "Hot Zone" models of granitoid generation and the need to refertilise lower crustal reservoirs to maintain magmatism. A new compilation of magmatic rock zircon Lu-Hf and O isotope data is used to demonstrate that the use of mantle-like O isotope data as a screening tool for "meaningful" Hf model ages is also unlikely to be reliable, with independently constrained data indicating that as few as 14% of Hf model ages provide a meaningful indicator of the timing of crustal growth. The limitations of Hf model ages are discussed with regard to existing approaches for continental growth and we demonstrate that popular inverse modelling approaches suffer from a bias created by both the use of model ages and numerical artefacts. In an effort to address some of the limitations within existing models, we develop stochastic models based on joint calibration of multiple datasets which allow for more unique solutions.

  17. Helical antiferromagnetic ordering in Lu1-xScxMnSi

    SciTech Connect

    Goetsch, Ryan J; Anand, V K; Johnston, David C

    2014-08-01

    Polycrystalline samples of Lu1-xScxMnSi (x=0, 0.25, 0.5) are studied using powder x-ray diffraction, heat capacity Cp, magnetization, magnetic susceptibility χ, and electrical resistivity ρ measurements versus temperature T and magnetic field H. This system crystallizes in the primitive orthorhombic TiNiSi-type structure (space group Pnma) as previously reported. The ρ(T) data indicate metallic behavior. The Cp(T), χ(T), and ρ(T) measurements consistently indicate long-range antiferromagnetic (AF) transitions with AF ordering temperatures TN=246, 215, and 188 K for x=0, 0.25, and 0.5, respectively. A second transition is observed at somewhat lower T for each sample from the χ(T) and ρ(T) measurements, which we speculate are due to spin reorientation transitions; these second transitions are completely suppressed in H=5.5 T. The Cp data below 10 K for each composition indicate an enhanced Sommerfeld electronic heat capacity coefficient for the series in the range γ=24–29 mJ/mol K2. The χ(T) measurements up to 1000 K were fitted by local-moment Curie-Weiss behaviors which indicate a low Mn spin S~1. The χ data below TN are analyzed using the Weiss molecular field theory for a planar noncollinear cycloidal AF structure with a composition-dependent pitch, following the previous neutron diffraction work of Venturini et al. [J. Alloys Compd. 256, 65 (1997)]. Within this model, the fits indicate a turn angle between Mn ordered moments along the cycloid axis of ~100° or ~145°, either of which indicate dominant AF interactions between the Mn spins in the Lu1-xScxMnSi series of compounds.

  18. Evidence for octupole vibration in the triaxial superdeformed well of {sup 164}Lu.

    SciTech Connect

    Bringel, P.; Engelhardt, C.; Hubel, H.; NeuBer-Neffgen, A.; Odegard, S. W.; Hagemann, G. B.; Hansen, C. R.; Herskind, B.; Sletten, G.; Carpenter, M. P.; Janssens, R. V. F.; Khoo, T. L.; Lauritsen, T.; Seweryniak, D.; Ma, W. C.; Roux, D. G.; Chowdhury, P.; Physics; Univ. Bonn; Univ. of Oslo; Niels Bohr Inst.; Mississippi State Univ.; Univ. of Massachusetts

    2007-01-01

    High-spin states in {sup 164}Lu were populated in the {sup 121}Sb({sup 48}Ca,5n) reaction at 215 MeV and {gamma}-ray coincidences were measured with the Gammasphere spectrometer. Through this experiment the eight known triaxial superdeformed bands in {sup 164}Lu could be confirmed. Some of these bands were extended to higher as well as to lower spins. Evidence is reported for the first time for weak {delta}I=1,E1 transitions linking TSD3 and TSD1. This observation may imply coupling to octupole vibrational degrees of freedom. The decay mechanism is different from the one observed in the neighboring even-N isotopes, which exhibit wobbling excitations built on the {pi}i{sub 13/2} structure with E2(M1),{delta}I=1 interband decay. An additional sequence decaying at high spin into TSD1 was observed up to I{sup {pi}}=(50{sup -}). This band has a constant dynamic moment of inertia of {approx}70({Dirac_h}/2{pi}){sup 2}MeV{sup -1} and an alignment that is {approx}2({Dirac_h}/2{pi}) larger than that found for TSD1. A revision of the assumed spin-parity-assignment of TSD2 is based on the observed decay-out to normal-deformed structures. The parity and signature quantum numbers of TSD2 are now firmly assigned as ({pi},{alpha})=(+,0), in disagreement with the former assignment of ({pi},{alpha})=(-,1), which was based on the assumption that TSD2 is the signature partner of TSD1. TSD1 and TSD2 show an alignment gain at ({Dirac_h}/2{pi}){omega}{approx}0.67 and 0.60 MeV, respectively. In TSD1 the involvement of the j{sub 15/2} neutron orbital is suggested to be responsible for the high-frequency crossing.

  19. Evidence for octupole vibration in the triaxial superdeformed well of {sup 164}Lu

    SciTech Connect

    Bringel, P.; Engelhardt, C.; Huebel, H.; Neusser-Neffgen, A.; Odega ring rd, S. W.; Hagemann, G. B.; Hansen, C. R.; Herskind, B.; Sletten, G.; Carpenter, M. P.; Janssens, R. V. F.; Khoo, T. L.; Lauritsen, T.; Seweryniak, D.; Ma, W. C.; Roux, D. G.; Chowdhury, P.

    2007-04-15

    High-spin states in {sup 164}Lu were populated in the {sup 121}Sb({sup 48}Ca,5n) reaction at 215 MeV and {gamma}-ray coincidences were measured with the Gammasphere spectrometer. Through this experiment the eight known triaxial superdeformed bands in {sup 164}Lu could be confirmed. Some of these bands were extended to higher as well as to lower spins. Evidence is reported for the first time for weak {delta}I=1,E1 transitions linking TSD3 and TSD1. This observation may imply coupling to octupole vibrational degrees of freedom. The decay mechanism is different from the one observed in the neighboring even-N isotopes, which exhibit wobbling excitations built on the {pi}i{sub 13/2} structure with E2(M1),{delta}I=1 interband decay. An additional sequence decaying at high spin into TSD1 was observed up to I{sup {pi}}=(50{sup -}). This band has a constant dynamic moment of inertia of {approx}70({Dirac_h}/2{pi}){sup 2}MeV{sup -1} and an alignment that is {approx}2({Dirac_h}/2{pi}) larger than that found for TSD1. A revision of the assumed spin-parity-assignment of TSD2 is based on the observed decay-out to normal-deformed structures. The parity and signature quantum numbers of TSD2 are now firmly assigned as ({pi},{alpha})=(+,0), in disagreement with the former assignment of ({pi},{alpha})=(-,1), which was based on the assumption that TSD2 is the signature partner of TSD1. TSD1 and TSD2 show an alignment gain at ({Dirac_h}/2{pi}){omega}{approx}0.67 and 0.60 MeV, respectively. In TSD1 the involvement of the j{sub 15/2} neutron orbital is suggested to be responsible for the high-frequency crossing.

  20. Lu.sub.1-xI.sub.3:Ce.sub.x-a scintillator for gamma-ray spectroscopy and time-of-flight pet

    DOEpatents

    Shah, Kanai S [Newton, MA

    2008-02-12

    The present invention includes very fast scintillator materials including lutetium iodide doped with Cerium (Lu.sub.1-xI.sub.3:Ce.sub.x; LuI.sub.3:Ce). The LuI.sub.3 scintillator material has surprisingly good characteristics including high light output, high gamma-ray stopping efficiency, fast response, low cost, good proportionality, and minimal afterglow that the material is useful for gamma-ray spectroscopy, medical imaging, nuclear and high energy physics research, diffraction, non-destructive testing, nuclear treaty verification and safeguards, and geological exploration.