Liquid zone seal

DOEpatents

Klebanoff, Leonard E.

2001-01-01

A seal assembly that provides a means for establishing multiple pressure zones within a system. The seal assembly combines a plate extending from the inner wall of a housing or inner enclosure that intersects with and is immersed in the fluid contained in a well formed in a tray contained within the enclosure. The fluid is a low vapor pressure oil, chemically inert and oxidation resistant. The use of a fluid as the sealing component provides a seal that is self-healing and mechanically robust not subject to normal mechanical wear, breakage, and formation of cracks or pinholes and decouples external mechanical vibrations from internal structural members.

[Comparison of Chemical Components of Essential Oil from Ocimum basilicum var. pilosum Extracted by Supercritical CO2 Fluid and Steam Distillation].

PubMed

Wang, Zhao-yu; Zheng, Jia-huan; Shi, Sheng-ying; Luo, Zhi-xiong; Ni, Shun-yu; Lin, Jing-ming

2015-11-01

To compare the chemical components of essential oil prepared by steam distillation extraction (SD) and supercritical CO2 fluid extraction (SFE-CO2) from Ocimum basilicum var. pilosum whole plant. The essential oil of Ocimum basilicum var. pilosum were extracted by SD and SFE-CO2. The chemical components of essential oil were separated and analyzed by gas chromatography-mass spectrometry( GC-MS). Their relative contents were determined by normalization of peak area. 40 and 42 compounds were detected in the essential oil prepared by SD and SFE-CO2 respectively. 25 compounds were common. Thereare significant differences of the chemical components between the Ocimum basilicum var. pilosum essential oil prepared by SD and thatby SFE-CO2. Different methods showed different extraction efficiency with a special compound. It might be a good idea to unite several methods in the modern traditional Chinese medicine industry.

14 CFR 29.1121 - General.

Code of Federal Regulations, 2010 CFR

2010-01-01

... to high temperatures from exhaust system parts, must be fireproof. Each exhaust system component must... ventilated to prevent points of excessively high temperature. (g) Each exhaust shroud must be ventilated or insulated to avoid, during normal operation, a temperature high enough to ignite any flammable fluids or...

Apparatus and method for thermal power generation

DOEpatents

Cohen, Paul; Redding, Arnold H.

1978-01-01

An improved thermal power plant and method of power generation which minimizes thermal stress and chemical impurity buildup in the vaporizing component, particularly beneficial under loss of normal feed fluid and startup conditions. The invention is particularly applicable to a liquid metal fast breeder reactor plant.

Cellular component of lavage fluid from broilers with normal versus aerosol-primed airways

USDA-ARS?s Scientific Manuscript database

Previously we reported that intratracheal administration of lipopolysaccharide (LPS) elicits pulmonary hypertension (PH) in broilers reared under commercial conditions, in broilers reared in environmental chambers and pre-treated with aerosolized red food colorant # 3 and propylene glycol (Red#3+PG)...

Raman spectroscopy of bio fluids: an exploratory study for oral cancer detection

NASA Astrophysics Data System (ADS)

Brindha, Elumalai; Rajasekaran, Ramu; Aruna, Prakasarao; Koteeswaran, Dornadula; Ganesan, Singaravelu

2016-03-01

ion for various disease diagnosis including cancers. Oral cancer is one of the most common cancers in India and it accounts for one third of the global oral cancer burden. Raman spectroscopy of tissues has gained much attention in the diagnostic oncology, as it provides unique spectral signature corresponding to metabolic alterations under different pathological conditions and micro-environment. Based on these, several studies have been reported on the use of Raman spectroscopy in the discrimination of diseased conditions from their normal counterpart at cellular and tissue level but only limited studies were available on bio-fluids. Recently, optical characterization of bio-fluids has also geared up for biomarker identification in the disease diagnosis. In this context, an attempt was made to study the metabolic variations in the blood, urine and saliva of oral cancer patients and normal subjects using Raman spectroscopy. Principal Component based Linear Discriminant Analysis (PC-LDA) followed by Leave-One-Out Cross-Validation (LOOCV) was employed to find the statistical significance of the present technique in discriminating the malignant conditions from normal subjects.

Exact Solutions for Nonlinear Development of a Kelvin-Helmholtz Instability for the Counterflow of Superfluid and Normal Components of Helium II.

PubMed

Lushnikov, Pavel M; Zubarev, Nikolay M

2018-05-18

Relative motion of the normal and superfluid components of helium II results in the quantum Kelvin-Helmholtz instability (KHI) at their common free surface. We found the integrability and exact growing solutions for the nonlinear stage of the development of that instability. Contrary to the usual KHI of the interface between two classical fluids, the dynamics of a helium II free surface allows reduction to the Laplace growth equation, which has an infinite number of exact solutions, including the generic formation of sharp cusps at the free surface in a finite time.

Exact Solutions for Nonlinear Development of a Kelvin-Helmholtz Instability for the Counterflow of Superfluid and Normal Components of Helium II

NASA Astrophysics Data System (ADS)

Lushnikov, Pavel M.; Zubarev, Nikolay M.

2018-05-01

Relative motion of the normal and superfluid components of helium II results in the quantum Kelvin-Helmholtz instability (KHI) at their common free surface. We found the integrability and exact growing solutions for the nonlinear stage of the development of that instability. Contrary to the usual KHI of the interface between two classical fluids, the dynamics of a helium II free surface allows reduction to the Laplace growth equation, which has an infinite number of exact solutions, including the generic formation of sharp cusps at the free surface in a finite time.

Bose-Einstein Condensation of a Stochastic Liquid

NASA Astrophysics Data System (ADS)

Maćkowiak, Jan

The Bogoliubov-Lee-Huang theory of superfluid 4He is modified by introducing an effective temperature scale (which accounts for the deep well of the interatomic potential) and by incorporating into the Hamiltonian a stochastic term Vl, which simulates liquidity of HeI and liquidity of the normal and superfluid component of HeII. Vl depends on two independent random angles αn, αs ∈ [0, π], which characterize the locally ordered motion of the two fluids (the normal fluid and superfluid) comprising HeII. The resulting thermodynamics improves the thermodynamic functions and excitation spectrum Ep(αn, αs) of the superfluid phase, obtained previously, leaving the heat capacity CV (T) of the normal phase, with a minimum at Tmin > 2.17K, unchanged. The theoretical velocity of sound in HeII, equal to the initial slope of Ep(π, π), agrees with experiment.

46 CFR 58.25-85 - Special requirements for tank vessels.

Code of Federal Regulations, 2011 CFR

2011-10-01

...” in paragraph (g) of this section refers to the pressure-containing components in hydraulic or electro... least two identical hydraulic-power actuating systems, which, acting simultaneously in normal operation... hydraulic fluid from one system must be capable of being detected, and the defective system automatically...

46 CFR 58.25-85 - Special requirements for tank vessels.

Code of Federal Regulations, 2014 CFR

2014-10-01

...” in paragraph (g) of this section refers to the pressure-containing components in hydraulic or electro... least two identical hydraulic-power actuating systems, which, acting simultaneously in normal operation... hydraulic fluid from one system must be capable of being detected, and the defective system automatically...

Infusion of solutions of pre-irradiated components in rats.

PubMed

Pappas, Georgina; Arnaud, Francoise; Haque, Ashraful; Kino, Tomoyuki; Facemire, Paul; Carroll, Erica; Auker, Charles; McCarron, Richard; Scultetus, Anke

2016-06-01

The objective of this study was to conduct a 14-day toxicology assessment for intravenous solutions prepared from irradiated resuscitation fluid components and sterile water. Healthy Sprague Dawley rats (7-10/group) were instrumented and randomized to receive one of the following Field IntraVenous Resuscitation (FIVR) or commercial fluids; Normal Saline (NS), Lactated Ringer's, 5% Dextrose in NS. Daily clinical observation, chemistry and hematology on days 1,7,14, and urinalysis on day 14 were evaluated for equivalence using a two sample t-test (p<0.05). A board-certified pathologist evaluated organ histopathology on day 14. Equivalence was established for all observation parameters, lactate, sodium, liver enzymes, creatinine, WBC and differential, and urinalysis values. Lack of equivalence for hemoglobin (p=0.055), pH (p=0.0955), glucose (p=0.0889), Alanine-Aminotransferase (p=0.1938), albumin (p=0.1311), and weight (p=0.0555, p=0.1896), was deemed not clinically relevant due to means within physiologically normal ranges. Common microscopic findings randomly distributed among animals of all groups were endocarditis/myocarditis and pulmonary lesions. These findings are consistent with complications due to long-term catheter use and suggest no clinically relevant differences in end-organ toxicity between animals infused with FIVR versus commercial fluids. Copyright © 2016 Elsevier GmbH. All rights reserved.

Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.

PubMed

Donson, Andrew M; Apps, John; Griesinger, Andrea M; Amani, Vladimir; Witt, Davis A; Anderson, Richard C E; Niazi, Toba N; Grant, Gerald; Souweidane, Mark; Johnston, James M; Jackson, Eric M; Kleinschmidt-DeMasters, Bette K; Handler, Michael H; Tan, Aik-Choon; Gore, Lia; Virasami, Alex; Gonzalez-Meljem, Jose Mario; Jacques, Thomas S; Martinez-Barbera, Juan Pedro; Foreman, Nicholas K; Hankinson, Todd C

2017-09-01

Pediatric adamantinomatous craniopharyngioma (ACP) is a highly solid and cystic tumor, often causing substantial damage to critical neuroendocrine structures such as the hypothalamus, pituitary gland, and optic apparatus. Paracrine signaling mechanisms driving tumor behavior have been hypothesized, with IL-6R overexpression identified as a potential therapeutic target. To identify potential novel therapies, we characterized inflammatory and immunomodulatory factors in ACP cyst fluid and solid tumor components. Cytometric bead analysis revealed a highly pro-inflammatory cytokine pattern in fluid from ACP compared to fluids from another cystic pediatric brain tumor, pilocytic astrocytoma. Cytokines and chemokines with particularly elevated concentrations in ACPs were IL-6, CXCL1 (GRO), CXCL8 (IL-8) and the immunosuppressive cytokine IL-10. These data were concordant with solid tumor compartment transcriptomic data from a larger cohort of ACPs, other pediatric brain tumors and normal brain. The majority of receptors for these cytokines and chemokines were also over-expressed in ACPs. In addition to IL-10, the established immunosuppressive factor IDO-1 was overexpressed by ACPs at the mRNA and protein levels. These data indicate that ACP cyst fluids and solid tumor components are characterized by an inflammatory cytokine and chemokine expression pattern. Further study regarding selective cytokine blockade may inform novel therapeutic interventions. © 2017 American Association of Neuropathologists, Inc. All rights reserved.

Relation between fluid intelligence and frontal lobe functioning in older adults.

PubMed

Isingrini, M; Vazou, F

1997-01-01

This study reports the relations among normal aging, intelligence, and frontal lobe functioning. Intelligence tasks and frontal lobe functioning tasks were administered to 107 adults from two age groups (25 to 46 years and 70 to 99 years). Intelligence measures were assessed with two crystallized tests (WAIS Vocabulary and Information subtests), one fluid intelligence test (Cattell's Matrices), and one mixed, crystallized and fluid test (WAIS Similarities subtest). Frontal functioning was assessed using the Wisconsin Card Sorting Test (WCST) and two tests of verbal fluency. Significant age differences in favor of the young were found on the two intelligence tests with a fluid component and on all measures of frontal lobe functioning. Correlational analyses examining the relationship of intelligence measures to frontal variables indicated that these last measures were significantly correlated with only fluid intelligence tests in the elderly group. The implications for the relations among aging, fluid intelligence, and frontal lobe functioning are discussed.

Impact of viscosity variation and micro rotation on oblique transport of Cu-water fluid.

PubMed

Tabassum, Rabil; Mehmood, R; Nadeem, S

2017-09-01

This study inspects the influence of temperature dependent viscosity on Oblique flow of micropolar nanofluid. Fluid viscosity is considered as an exponential function of temperature. Governing equations are converted into dimensionless forms with aid of suitable transformations. Outcomes of the study are shown in graphical form and discussed in detail. Results revealed that viscosity parameter has pronounced effects on velocity profiles, temperature distribution, micro-rotation, streamlines, shear stress and heat flux. It is found that viscosity parameter enhances the temperature distribution, tangential velocity profile, normal component of micro-rotation and shear stress at the wall while it has decreasing effect on tangential component of micro-rotation and local heat flux. Copyright © 2017 Elsevier Inc. All rights reserved.

Static Feed Water Electrolysis Subsystem Testing and Component Development

NASA Technical Reports Server (NTRS)

Koszenski, E. P.; Schubert, F. H.; Burke, K. A.

1983-01-01

A program was carried out to develop and test advanced electrochemical cells/modules and critical electromechanical components for a static feed (alkaline electrolyte) water electrolysis oxygen generation subsystem. The accomplishments were refurbishment of a previously developed subsystem and successful demonstration for a total of 2980 hours of normal operation; achievement of sustained one-person level oxygen generation performance with state-of-the-art cell voltages averaging 1.61 V at 191 ASF for an operating temperature of 128F (equivalent to 1.51V when normalized to 180F); endurance testing and demonstration of reliable performance of the three-fluid pressure controller for 8650 hours; design and development of a fluid control assembly for this subsystem and demonstration of its performance; development and demonstration at the single cell and module levels of a unitized core composite cell that provides expanded differential pressure tolerance capability; fabrication and evaluation of a feed water electrolyte elimination five-cell module; and successful demonstration of an electrolysis module pressurization technique that can be used in place of nitrogen gas during the standby mode of operation to maintain system pressure and differential pressures.

Phase change water processing for Space Station

NASA Technical Reports Server (NTRS)

Zdankiewicz, E. M.; Price, D. F.

1985-01-01

The use of a vapor compression distillation subsystem (VCDS) for water recovery on the Space Station is analyzed. The self-contained automated system can process waste water at a rate of 32.6 kg/day and requires only 115 W of electric power. The improvements in the mechanical components of VCDS are studied. The operation of VCDS in the normal mode is examined. The VCDS preprototype is evaluated based on water quality, water production rate, and specific energy. The relation between water production rate and fluids pump speed is investigated; it is concluded that a variable speed fluids pump will optimize water production. Components development and testing currently being conducted are described. The properties and operation of the proposed phase change water processing system for the Space Station, based on vapor compression distillation, are examined.

Time-frequency analyses of fluid-solid interaction under sinusoidal translational shear deformation of the viscoelastic rat cerebrum

NASA Astrophysics Data System (ADS)

Leahy, Lauren N.; Haslach, Henry W.

2018-02-01

During normal extracellular fluid (ECF) flow in the brain glymphatic system or during pathological flow induced by trauma resulting from impacts and blast waves, ECF-solid matter interactions result from sinusoidal shear waves in the brain and cranial arterial tissue, both heterogeneous biological tissues with high fluid content. The flow in the glymphatic system is known to be forced by pulsations of the cranial arteries at about 1 Hz. The experimental shear stress response to sinusoidal translational shear deformation at 1 Hz and 25% strain amplitude and either 0% or 33% compression is compared for rat cerebrum and bovine aortic tissue. Time-frequency analyses aim to correlate the shear stress signal frequency components over time with the behavior of brain tissue constituents to identify the physical source of the shear nonlinear viscoelastic response. Discrete fast Fourier transformation analysis and the novel application to the shear stress signal of harmonic wavelet decomposition both show significant 1 Hz and 3 Hz components. The 3 Hz component in brain tissue, whose magnitude is much larger than in aortic tissue, may result from interstitial fluid induced drag forces. The harmonic wavelet decomposition locates 3 Hz harmonics whose magnitudes decrease on subsequent cycles perhaps because of bond breaking that results in easier fluid movement. Both tissues exhibit transient shear stress softening similar to the Mullins effect in rubber. The form of a new mathematical model for the drag force produced by ECF-solid matter interactions captures the third harmonic seen experimentally.

Interstitial hydraulic conductivity and interstitial fluid pressure for avascular or poorly vascularized tumors.

PubMed

Liu, L J; Schlesinger, M

2015-09-07

A correct description of the hydraulic conductivity is essential for determining the actual tumor interstitial fluid pressure (TIFP) distribution. Traditionally, it has been assumed that the hydraulic conductivities both in a tumor and normal tissue are constant, and that a tumor has a much larger interstitial hydraulic conductivity than normal tissue. The abrupt transition of the hydraulic conductivity at the tumor surface leads to non-physical results (the hydraulic conductivity and the slope of the TIFP are not continuous at tumor surface). For the sake of simplicity and the need to represent reality, we focus our analysis on avascular or poorly vascularized tumors, which have a necrosis that is mostly in the center and vascularization that is mostly on the periphery. We suggest that there is an intermediary region between the tumor surface and normal tissue. Through this region, the interstitium (including the structure and composition of solid components and interstitial fluid) transitions from tumor to normal tissue. This process also causes the hydraulic conductivity to do the same. We introduce a continuous variation of the hydraulic conductivity, and show that the interstitial hydraulic conductivity in the intermediary region should be monotonically increasing up to the value of hydraulic conductivity in the normal tissue in order for the model to correspond to the actual TIFP distribution. The value of the hydraulic conductivity at the tumor surface should be the lowest in value. Copyright © 2015 Elsevier Ltd. All rights reserved.

Dry eye symptoms are increased in mice deficient in phospholipid transfer protein (PLTP).

PubMed

Setälä, Niko L; Metso, Jari; Jauhiainen, Matti; Sajantila, Antti; Holopainen, Juha M

2011-05-01

In the tear fluid the outermost part facing the tear-air interface is composed of lipids preventing evaporation of the tears. Phospholipid transfer protein (PLTP) mediates phospholipid transfer processes between serum lipoproteins and is also a normal component of human tears. To study whether PLTP plays any functional role in tear fluid we investigated PLTP-deficient mice, applying functional and morphologic analyses under normal housing and experimentally induced dry eye conditions. Aqueous tear fluid production, corneal epithelial morphology, barrier function, and occludin expression were assessed. In mice with a full deficiency of functional PLTP enhanced corneal epithelial damage, increased corneal permeability to carboxyfluorescein, and decreased corneal epithelial occludin expression were shown. These pathologic signs were worsened by experimentally induced dry eye both in wild-type and PLTP knock-out mice. Deficiency in the production of tear PLTP in mice is accompanied by corneal epithelial damage, a feature that is typical in human dry eye syndrome (DES). To complement animal experiments we collected tear fluid from human dry eye patients as well as healthy control subjects. Increased tear fluid PLTP activity was observed among DES patients. In conclusion, the presence of PLTP in tear fluid appears to be essential for maintaining a healthy and functional ocular surface. Increased PLTP activity in human tear fluid in DES patients suggests an ocular surface protective role for this lipid transfer protein. Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Multiphase Flow Technology Impacts on Thermal Control Systems for Exploration

NASA Technical Reports Server (NTRS)

McQuillen, John; Sankovic, John; Lekan, Jack

2006-01-01

The Two-Phase Flow Facility (TPHIFFy) Project focused on bridging the critical knowledge gap by developing and demonstrating critical multiphase fluid products for advanced life support, thermal management and power conversion systems that are required to enable the Vision for Space Exploration. Safety and reliability of future systems will be enhanced by addressing critical microgravity fluid physics issues associated with flow boiling, condensation, phase separation, and system stability. The project included concept development, normal gravity testing, and reduced gravity aircraft flight campaigns, in preparation for the development of a space flight experiment implementation. Data will be utilized to develop predictive models that could be used for system design and operation. A single fluid, two-phase closed thermodynamic loop test bed was designed, assembled and tested. The major components in this test bed include: a boiler, a condenser, a phase separator and a circulating pump. The test loop was instrumented with flow meters, thermocouples, pressure transducers and both high speed and normal speed video cameras. A low boiling point surrogate fluid, FC-72, was selected based on scaling analyses using preliminary designs for operational systems. Preliminary results are presented which include flow regime transitions and some observations regarding system stability.

Quantitation of sperm bindable IgA and IgG in seminal fluid.

PubMed

Howe, S E; Lynch, D M

1986-05-01

Seminal fluid and serum from 95 infertile males were assayed for sperm bindable immunoglobulins using an indirect ELISA with whole target sperm. The ELISA method was compared to seminal fluid and serum immobilization and agglutination assays (functional assays). In this infertile group, the ELISA assay was positive in 22% of seminal fluids (greater than 1.2 fg IgA/sperm and greater than 0.3 fg IgG/sperm). The seminal fluid antibodies were IgA and had an accompanying elevated IgG component in 78% of patients. There was a 96% correlation between negative seminal fluid functional assays and negative ELISA, and a 95% correlation between positive seminal fluid functional assays and positive ELISA. Positive serum sperm antibody tests were found in 71% of the infertile males with positive seminal fluid sperm antibodies, but 29% of the infertile males with strongly positive IgA seminal fluid sperm antibodies showed normal levels of serum sperm antibodies by either ELISA or functional assays. The ELISA method gives reproducible quantitation of sperm antibodies in seminal fluid and correlates well with accepted functional assays. Comparisons with serum sperm antibody assays suggests that seminal fluid sperm antibody analysis complements the serum analysis of sperm antibodies.

Disproportionate entrance length in superfluid flows and the puzzle of counterflow instabilities

NASA Astrophysics Data System (ADS)

Bertolaccini, J.; Lévêque, E.; Roche, P.-E.

2017-12-01

Systematic simulations of the two-fluid model of superfluid helium (He-II) encompassing the Hall-Vinen-Bekharevich-Khalatnikov (HVBK) mutual coupling have been performed in two-dimensional pipe counterflows between 1.3 and 1.96 K. The numerical scheme relies on the lattice Boltzmann method. A Boussinesq-like hypothesis is introduced to omit temperature variations along the pipe. In return, the thermomechanical forcings of the normal and superfuid components are fueled by a pressure term related to their mass-density variations under an approximation of weak compressibility. This modeling framework reproduces the essential features of a thermally driven counterflow. A generalized definition of the entrance length is introduced to suitably compare entry effects (of different nature) at opposite ends of the pipe. This definition is related to the excess of pressure loss with respect to the developed Poiseuille-flow solution. At the heated end of the pipe, it is found that the entrance length for the normal fluid follows a classical law and increases linearly with the Reynolds number. At the cooled end, the entrance length for the superfluid is enhanced as compared to the normal fluid by up to one order of magnitude. At this end, the normal fluid flows into the cooling bath of He-II and produces large-scale superfluid vortical motions in the bath that partly re-enter the pipe along its sidewalls before being damped by mutual friction. In the superfluid entry region, the resulting frictional coupling in the superfluid boundary layer distorts the velocity profiles toward tail flattening for the normal fluid and tail raising for the superfluid. Eventually, a simple analytical model of entry effects allows us to re-examine the long-debated thresholds of T 1 and T 2 instabilities in superfluid counterflows. Inconsistencies in the T 1 thresholds reported since the 1960s disappear if an aspect-ratio criterion based on our modeling is used to discard data sets with the strongest entry effects. Furthermore, it is observed that entry effects can spuriously reproduce the signature of a T 2 transition with a normal flow remaining laminar.

Lattice Boltzmann model for three-phase viscoelastic fluid flow

NASA Astrophysics Data System (ADS)

Xie, Chiyu; Lei, Wenhai; Wang, Moran

2018-02-01

A lattice Boltzmann (LB) framework is developed for simulation of three-phase viscoelastic fluid flows in complex geometries. This model is based on a Rothman-Keller type model for immiscible multiphase flows which ensures mass conservation of each component in porous media even for a high density ratio. To account for the viscoelastic effects, the Maxwell constitutive relation is correctly introduced into the momentum equation, which leads to a modified lattice Boltzmann evolution equation for Maxwell fluids by removing the normal but excess viscous term. Our simulation tests indicate that this excess viscous term may induce significant errors. After three benchmark cases, the displacement processes of oil by dispersed polymer are studied as a typical example of three-phase viscoelastic fluid flow. The results show that increasing either the polymer intrinsic viscosity or the elastic modulus will enhance the oil recovery.

Effect of electron beam on the properties of electron-acoustic rogue waves

NASA Astrophysics Data System (ADS)

El-Shewy, E. K.; Elwakil, S. A.; El-Hanbaly, A. M.; Kassem, A. I.

2015-04-01

The properties of nonlinear electron-acoustic rogue waves have been investigated in an unmagnetized collisionless four-component plasma system consisting of a cold electron fluid, Maxwellian hot electrons, an electron beam and stationary ions. It is found that the basic set of fluid equations is reduced to a nonlinear Schrodinger equation. The dependence of rogue wave profiles and the associated electric field on the carrier wave number, normalized density of hot electron and electron beam, relative cold electron temperature and relative beam temperature are discussed. The results of the present investigation may be applicable in auroral zone plasma.

Spin Diffusion Coefficient of A1-PHASE of Superfluid 3He at Low Temperatures

NASA Astrophysics Data System (ADS)

Afzali, R.; Pashaee, F.

The spin diffusion coefficient tensor of the A1-phase of superfluid 3He at low temperatures and melting pressure is calculated using the Boltzmann equation approach and Pfitzner procedure. Then considering Bogoliubov-normal interaction, we show that the total spin diffusion is proportional to 1/T2, the spin diffusion coefficient of superfluid component D\\uparrowxzxz is proportional to T-2, and the spin diffusion coefficient of super-fluid component D\\uparrowxxxx (=D\\uarrowxyxy) is independent of temperature. Furthermore, it is seen that superfluid components play an important role in spin diffusion of the A1-phase.

Spray Formation from a Charged Liquid Jet of a Dielectric Fluid

NASA Astrophysics Data System (ADS)

Doak, William; de Bellis, Victor; Chiarot, Paul; Microfluidics; Multiphase Flow Laboratory Team

2017-11-01

Atomization of a dielectric micro-jet is achieved via an electrohydrodynamic charge injection process. The atomizer is comprised of a grounded nozzle housing (ground electrode) and an internal probe (high voltage electrode) that is concentric with the emitting orifice. The internal probe is held at electric potentials ranging from 1-10 kV. A pressurized reservoir drives a dielectric fluid at a desired flow rate through the 100-micrometer diameter orifice. The fluid fills the cavity between the electrodes as it passes through the atomizer, impeding the transport of electrons. This process injects charge into the flowing fluid. Upon exiting the orifice, the emitted jet is highly charged and it deforms via a bending instability that is qualitatively similar to the behavior observed in the electrospinning of fibers. We observed bulging regions, or nodes, of highly charged fluid forming along the bent, rotating jet. These nodes separate into highly charged droplets that emit satellite droplets. The remaining ligaments break up due to capillarity in a process that produces additional satellites. All of the droplets possess a normal (inertial) and radial (electrically-driven) momentum component. The radial component is responsible for the formation of a conical spray envelope. Our research focuses on the jet, its break up, and the droplet dynamics of this system. This research supported by the American Chemical Society.

Brain tissue pulsatility mediates cognitive and electrophysiological changes in normal aging: Evidence from ultrasound tissue pulsatility imaging (TPI).

PubMed

Angel, Lucie; Bouazzaoui, Badiâa; Isingrini, Michel; Fay, Séverine; Taconnat, Laurence; Vanneste, Sandrine; Ledoux, Moïse; Gissot, Valérie; Hommet, Caroline; Andersson, Fréderic; Barantin, Laurent; Cottier, Jean-Philippe; Pasco, Jérémy; Desmidt, Thomas; Patat, Frédéric; Camus, Vincent; Remenieras, Jean-Pierre

2018-06-01

Aging is characterized by a cognitive decline of fluid abilities and is also associated with electrophysiological changes. The vascular hypothesis proposes that brain is sensitive to vascular dysfunction which may accelerate age-related brain modifications and thus explain age-related neurocognitive decline. To test this hypothesis, cognitive performance was measured in 39 healthy participants from 20 to 80 years, using tests assessing inhibition, fluid intelligence, attention and crystallized abilities. Brain functioning associated with attentional abilities was assessed by measuring the P3b ERP component elicited through an auditory oddball paradigm. To assess vascular health, we used an innovative measure of the pulsatility of deep brain tissue, due to variations in cerebral blood flow over the cardiac cycle. Results showed (1) a classical effect of age on fluid neurocognitive measures (inhibition, fluid intelligence, magnitude and latency of the P3b) but not on crystallized measures, (2) that brain pulsatility decreases with advancing age, (3) that brain pulsatility is positively correlated with fluid neurocognitive measures and (4) that brain pulsatility strongly mediated the age-related variance in cognitive performance and the magnitude of the P3b component. The mediating role of the brain pulsatility in age-related effect on neurocognitive measures supports the vascular hypothesis of cognitive aging. Copyright © 2018 Elsevier Inc. All rights reserved.

Exploration of thermal counterflow in He II using particle tracking velocimetry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mastracci, Brian; Guo, Wei

Flow visualization using particle image velocimetry (PIV) and particularly particle tracking velocimetry (PTV) has been applied to thermal counterflow in He II for nearly two decades now, but the results remain difficult to interpret because tracer particle motion can be influenced by both the normal fluid and superfluid components of He II as well as the quantized vortex tangle. For instance, in one early experiment it was observed (using PTV) that tracer particles move at the normal fluid velocity v n, while in another it was observed (using PIV) that particles move at v n/2. Besides the different visualization methods,more » the range of applied heat flux investigated by these experiments differed by an order of magnitude. To resolve this apparent discrepancy and explore the statistics of particle motion in thermal counterflow, we apply the PTV method to a wide range of heat flux at a number of different fluid temperatures. In our analysis, we introduce a scheme for analyzing the velocity of particles presumably moving with the normal fluid separately from those presumably influenced by the quantized vortex tangle. Our results show that for lower heat flux there are two distinct peaks in the streamwise particle velocity probability density function (PDF), with one centered at the normal fluid velocity v n (named G2 for convenience) while the other is centered near v n/2 (G1). For higher heat flux there is a single peak centered near v n/2 (G3). Using our separation scheme, we show quantitatively that there is no size difference between the particles contributing to G1 and G2. We also show that nonclassical features of the transverse particle velocity PDF arise entirely from G1, while the corresponding PDF for G2 exhibits the classical Gaussian form. The G2 transverse velocity fluctuation, backed up by second sound attenuation in decaying counterflow, suggests that large-scale turbulence in the normal fluid is absent from the two-peak region. We offer a brief discussion of the physical mechanisms that may be responsible for our observations, revealing that G1 velocity fluctuations may be linked to fluctuations of quantized vortex line velocity, and suggest a number of numerical simulations that may reveal the underlying physics in detail.« less

Exploration of thermal counterflow in He II using particle tracking velocimetry

DOE PAGES

Mastracci, Brian; Guo, Wei

2018-06-22

Flow visualization using particle image velocimetry (PIV) and particularly particle tracking velocimetry (PTV) has been applied to thermal counterflow in He II for nearly two decades now, but the results remain difficult to interpret because tracer particle motion can be influenced by both the normal fluid and superfluid components of He II as well as the quantized vortex tangle. For instance, in one early experiment it was observed (using PTV) that tracer particles move at the normal fluid velocity v n, while in another it was observed (using PIV) that particles move at v n/2. Besides the different visualization methods,more » the range of applied heat flux investigated by these experiments differed by an order of magnitude. To resolve this apparent discrepancy and explore the statistics of particle motion in thermal counterflow, we apply the PTV method to a wide range of heat flux at a number of different fluid temperatures. In our analysis, we introduce a scheme for analyzing the velocity of particles presumably moving with the normal fluid separately from those presumably influenced by the quantized vortex tangle. Our results show that for lower heat flux there are two distinct peaks in the streamwise particle velocity probability density function (PDF), with one centered at the normal fluid velocity v n (named G2 for convenience) while the other is centered near v n/2 (G1). For higher heat flux there is a single peak centered near v n/2 (G3). Using our separation scheme, we show quantitatively that there is no size difference between the particles contributing to G1 and G2. We also show that nonclassical features of the transverse particle velocity PDF arise entirely from G1, while the corresponding PDF for G2 exhibits the classical Gaussian form. The G2 transverse velocity fluctuation, backed up by second sound attenuation in decaying counterflow, suggests that large-scale turbulence in the normal fluid is absent from the two-peak region. We offer a brief discussion of the physical mechanisms that may be responsible for our observations, revealing that G1 velocity fluctuations may be linked to fluctuations of quantized vortex line velocity, and suggest a number of numerical simulations that may reveal the underlying physics in detail.« less

Supercritical fluid extraction of the non-polar organic compounds in meteorites

NASA Astrophysics Data System (ADS)

Sephton, M. A.; Pillinger, C. T.; Gilmour, I.

2001-01-01

The carbonaceous chondrite meteorites contain a variety of extraterrestrial organic molecules. These organic components provide a valuable insight into the formation and evolution of the solar system. Attempts at obtaining and interpreting this information source are hampered by the small sample sizes available for study and the interferences from terrestrial contamination. Supercritical fluid extraction represents an efficient and contamination-free means of isolating extraterrestrial molecules. Gas chromatography-mass spectrometry analyses of extracts from Orgueil and Cold Bokkeveld reveal a complex mixture of free non-polar organic molecules which include normal alkanes, isoprenoid alkanes, tetrahydronaphthalenes and aromatic hydrocarbons. These organic assemblages imply contributions from both terrestrial and extraterrestrial sources.

Dilational processes accompanying earthquakes in the Long Valley Caldera

USGS Publications Warehouse

Dreger, Douglas S.; Tkalcic, Hrvoje; Johnston, M.

2000-01-01

Regional distance seismic moment tensor determinations and broadband waveforms of moment magnitude 4.6 to 4.9 earthquakes from a November 1997 Long Valley Caldera swarm, during an inflation episode, display evidence of anomalous seismic radiation characterized by non-double couple (NDC) moment tensors with significant volumetric components. Observed coseismic dilation suggests that hydrothermal or magmatic processes are directly triggering some of the seismicity in the region. Similarity in the NDC solutions implies a common source process, and the anomalous events may have been triggered by net fault-normal stress reduction due to high-pressure fluid injection or pressurization of fluid-saturated faults due to magmatic heating.

Nanoscale wicking methods and devices

NASA Technical Reports Server (NTRS)

Zhou, Jijie (Inventor); Bronikowski, Michael (Inventor); Noca, Flavio (Inventor); Sansom, Elijah B. (Inventor)

2011-01-01

A fluid transport method and fluid transport device are disclosed. Nanoscale fibers disposed in a patterned configuration allow transport of a fluid in absence of an external power source. The device may include two or more fluid transport components having different fluid transport efficiencies. The components may be separated by additional fluid transport components, to control fluid flow.

Zn concentration in plasma and gastric fluid in patients with upper gastrointestinal disease

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kadakia, S.C.; Wong, R.H.K.; Maydonovitch, C.

1986-03-05

Very few data are available about Zn in gastrointestinal fluids in humans. To obtain data in one such fluid Zn was measured in plasma and gastric fluid, obtained by direct visual aspiration through an endoscope placed into the gastric fundus, in 36 subjects with normal gastrointestinal mucosa (N) and in 36 patients with the following upper gastrointestinal pathology confirmed by endoscopy: 13 with esophagitis (E), 9 with gastritis (G) and 14 with duodenal ulcer disease (DU). Plasma and gastric fluid Zn were estimated by flame atomic absorption spectrophotometry. Mean plasma Zn was significantly lower than normal in patients with Emore » (N, 87 +/- 2 ..mu..g/dl, M +/- SEM; E, 75 +/- 4, p < 0.01) but plasma values were similar to normal in the other patient groups (G, 89 +/- 4; DU, 87 +/- 2). Mean gastric fluid zinc in G was significantly higher than in normal subjects (G, 664 +/- 159 ..mu..g/L; N, 360 +/- 43, p < 0.02) but not significantly different from normal in patients with DU or E (DU, 402 +/- 76; E, 307 +/- 55). Mean gastric fluid Zn in women with DU was approximately 45% higher than in men with DU, although it was 17% lower in normal women than in normal men. Compared to other normal tissues gastric fluid Zn is about 1/3 that in serum and about 3 times that in saliva. These results indicate that Zn in plasma and gastric fluid is altered in some upper gastrointestinal diseases.« less

Method for removing impurities from an impurity-containing fluid stream

DOEpatents

Ginosar, Daniel M.; Fox, Robert V.

2010-04-06

A method of removing at least one polar component from a fluid stream. The method comprises providing a fluid stream comprising at least one nonpolar component and at least one polar component. The fluid stream is contacted with a supercritical solvent to remove the at least one polar component. The at least one nonpolar component may be a fat or oil and the at least one polar component may be water, dirt, detergents, or mixtures thereof. The supercritical solvent may decrease solubility of the at least one polar component in the fluid stream. The supercritical solvent may function as a solvent or as a gas antisolvent. The supercritical solvent may dissolve the nonpolar components of the fluid stream, such as fats or oils, while the polar components may be substantially insoluble. Alternatively, the supercritical solvent may be used to increase the nonpolarity of the fluid stream.

The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: potential therapeutic consequences.

PubMed

Wiig, Helge; Gyenge, Christina; Iversen, Per Ole; Gullberg, Donald; Tenstad, Olav

2008-05-01

The interstitial space is a dynamic microenvironment that consists of interstitial fluid and structural molecules of the extracellular matrix, such as glycosaminoglycans (hyaluronan and proteoglycans) and collagen. Macromolecules can distribute in the interstitium only in those spaces unoccupied by structural components, a phenomenon called interstitial exclusion. The exclusion phenomenon has direct consequences for plasma volume regulation. Early studies have assigned a major role to collagen as an excluding agent that accounts for the sterical (geometrical) exclusion. More recently, it has been shown that the contribution of negatively charged glycosaminoglycans might also be significant, resulting in an additional electrostatical exclusion effect. This charge effect may be of importance for drug uptake and suggests that either the glycosaminoglycans or the net charge of macromolecular substances to be delivered may be targeted to increase the available volume and uptake of macromolecular therapeutic agents in tumor tissue. Here, we provide an overview of the structural components of the interstitium and discuss the importance the sterical and electrostatical components have on the dynamics of transcapillary fluid exchange.

Distance-from-the-wall scaling of turbulent motions in wall-bounded flows

NASA Astrophysics Data System (ADS)

Baidya, R.; Philip, J.; Hutchins, N.; Monty, J. P.; Marusic, I.

2017-02-01

An assessment of self-similarity in the inertial sublayer is presented by considering the wall-normal velocity, in addition to the streamwise velocity component. The novelty of the current work lies in the inclusion of the second velocity component, made possible by carefully conducted subminiature ×-probe experiments to minimise the errors in measuring the wall-normal velocity. We show that not all turbulent stress quantities approach the self-similar asymptotic state at an equal rate as the Reynolds number is increased, with the Reynolds shear stress approaching faster than the streamwise normal stress. These trends are explained by the contributions from attached eddies. Furthermore, the Reynolds shear stress cospectra, through its scaling with the distance from the wall, are used to assess the wall-normal limits where self-similarity applies within the wall-bounded flow. The results are found to be consistent with the recent prediction from the work of Wei et al. ["Properties of the mean momentum balance in turbulent boundary layer, pipe and channel flows," J. Fluid Mech. 522, 303-327 (2005)], Klewicki ["Reynolds number dependence, scaling, and dynamics of turbulent boundary layers," J. Fluids Eng. 132, 094001 (2010)], and others that the self-similar region starts and ends at z+˜O (√{δ+}) and O (δ+) , respectively. Below the self-similar region, empirical evidence suggests that eddies responsible for turbulent stresses begin to exhibit distance-from-the-wall scaling at a fixed z+ location; however, they are distorted by viscous forces, which remain a leading order contribution in the mean momentum balance in the region z+≲O (√{δ+}) , and thus result in a departure from self-similarity.

Portable Medical Diagnosis Instrument

NASA Technical Reports Server (NTRS)

Coleman, Matthew A. (Inventor); Straume, Tore (Inventor); Loftus, David J. (Inventor); Li, Jing (Inventor); Singh, Anup K. (Inventor); Davis, Cristina E. (Inventor)

2017-01-01

A system that integrates several technologies into a single, portable medical diagnostic apparatus for analyzing a sample body fluid (liquid and/or gas): (1) a mechanism to capture airborne microdroplets and to separate the body fluid into a first fluid component (primarily gas) and a second fluid component (primarily liquid); (2) a volatilizer to convert a portion of the second fluid component into a third fluid component that is primarily a gas; (3) a functionalized nanostructure (NS) array configured to receive, identify, and estimate concentration of at least one constituent in the first and/or third fluid components; (4) a miniaturized differential mobility spectrometer (DMS) module; and (5) a biomarker sensor, to detect volatile and non-volatile molecules in a sample fluid, which may contain one or more components of blood, breath, perspiration, saliva, and urine.

Immune complexes and Ross River virus disease (epidemic polyarthritis).

PubMed

Fraser, J R; Cunningham, A L; Mathews, J D; Riglar, A

1988-01-01

Immune complexes were sought in serum and synovial fluid in Ross River virus disease (epidemic polyarthritis). Multiple samples from 15 patients showing varied degrees of disease activity over a 3 month period were analysed for their content of complement components C3 and C4, and for C1q solid-phase and Raji cell binding activity. Levels of C3 and C1q binding activity were normal. C4 and Raji cell binding activity were normal except for three high levels of Raji cell binding, of which two were accompanied by low levels of C4, with normal C3 and C1q binding. Synovial fluid showed anomalous Raji cell reactivity of uncertain significance. Conglutinin solid-phase binding activity and IgG rheumatoid factor were compared in the serum of 20 patients during active disease and after recovery. The results were identical and within the normal range in both phases. One patient developed IgM rheumatoid factor in a low titre late in his illness. Although these findings do not entirely exclude a role for immune complexes formed at the onset in the circulation or tissues, it is concluded from this and other evidence that circulating complexes are not commonly responsible for the persistence of syndromes in this disease.

Two-Fluid Description of Collisionless Perpendicular Shocks

NASA Astrophysics Data System (ADS)

Gomez, D. O.; Morales, L. F.; Dmitruk, P.; Bertucci, C.

2017-12-01

Collisionless shocks are ubiquitous in space physics and astrophysics, such as the bow shocks formed by the solar wind in front of planets, the termination shock at the heliospheric boundary or the supernova shock fronts expanding in the interstellar plasma. Although the one-fluid magnetohydrodynamic framework provides a reasonable description of the large scale structures of the upstream and downstream plasmas, it falls short of providing an adequate description of the internal structure of the shock. A more comprehensive description of the inner and outer features of collisionless shocks would require the use of kinetic theory. Nonetheless, in the present work we show that a complete two-fluid framework (considering the role of both ions and electrons in the dynamics) can properly capture some of the features observed in real shocks. For the specific case of perpendicular shocks, i.e. cases in which the magnetic field is perpendicular to the shock normal, we integrate the one-dimensional two-fluid MHD equations numerically, to describe the generation of shocks and their spatial structure along the shock normal. Starting from finite amplitude fast-magnetosonic waves, our simulations show the generation of a stationary fast-magnetosonic shock. More importantly, we show that the ramp thickness is of the order of a few electron inertial lengths. The parallel and perpendicular components of the self-consistent electric field are derived, and their role in accelerating particles is discussed.

Fluid pathways from mantle wedge up to forearc seafloor in the coseismic slip area of the 2011 Tohoku earthquake

NASA Astrophysics Data System (ADS)

Park, J. O.; Tsuru, T.; Fujie, G.; Kagoshima, T.; Sano, Y.

2017-12-01

A lot of fluids at subduction zones are exchanged between the solid Earth and ocean, affecting the earthquake and tsunami generation. New multi-channel seismic reflection and sub-bottom profiling data reveal normal and reverse faults as the fluid pathways in the coseismic slip area of the 2011 Tohoku earthquake (M9.0). Based on seismic reflection characteristics and helium isotope anomalies, we recognize variations in fluid pathways (i.e., faults) from the mantle wedge up to forearc seafloor in the Japan Trench margin. Some fluids are migrated from the mantle wedge along plate interface and then normal or reverse faults cutting through the overriding plate. Others from the mantle wedge are migrated directly up to seafloor along normal faults, without passing through the plate interface. Locations of the normal faults are roughly consistent with aftershocks of the 2011 Tohoku earthquake, which show focal mechanism of normal faulting. It is noticeable that landward-dipping normal faults developing down into Unit C (Cretaceous basement) from seafloor are dominant in the middle slope region where basal erosion is inferred to be most active. A high-amplitude, reverse-polarity reflection of the normal faults within Unit C suggests that the fluids are locally trapped along the faults in high pore pressures. The 2011 Tohoku mainshock and subsequent aftershocks could lead the pre-existing normal faults to be reactive and more porous so that the trapped fluids are easily transported up to seafloor through the faults. Elevated fluid pressures can decrease the effective normal stress for the fault plane, allowing easier slip of the landward-dipping normal fault and also enhancing its tsunamigenic potential.

Submarine gas seepage in a mixed contractional and shear deformation regime: Cases from the Hikurangi oblique-subduction margin

NASA Astrophysics Data System (ADS)

Plaza-Faverola, Andreia; Pecher, Ingo; Crutchley, Gareth; Barnes, Philip M.; Bünz, Stefan; Golding, Thomas; Klaeschen, Dirk; Papenberg, Cord; Bialas, Joerg

2014-02-01

Gas seepage from marine sediments has implications for understanding feedbacks between the global carbon reservoir, seabed ecology, and climate change. Although the relationship between hydrates, gas chimneys, and seafloor seepage is well established, the nature of fluid sources and plumbing mechanisms controlling fluid escape into the hydrate zone and up to the seafloor remain one of the least understood components of fluid migration systems. In this study, we present the analysis of new three-dimensional high-resolution seismic data acquired to investigate fluid migration systems sustaining active seafloor seepage at Omakere Ridge, on the Hikurangi subduction margin, New Zealand. The analysis reveals at high resolution, complex overprinting fault structures (i.e., protothrusts, normal faults from flexural extension, and shallow (<1 km) arrays of oblique shear structures) implicated in fluid migration within the gas hydrate stability zone in an area of 2 × 7 km. In addition to fluid migration systems sustaining seafloor seepage on both sides of a central thrust fault, the data show seismic evidence for subseafloor gas-rich fluid accumulation associated with proto-thrusts and extensional faults. In these latter systems fluid pressure dissipation through time has been favored, hindering the development of gas chimneys. We discuss the elements of the distinct fluid migration systems and the influence that a complex partitioning of stress may have on the evolution of fluid flow systems in active subduction margins.

Targeted Zinc Delivery: A Novel Treatment for Prostate Cancer

DTIC Science & Technology

2010-06-01

aconitase, which normally functions to oxidize citrate during the Krebs cycle . Because citrate is a principle component of seminal fluid, prostate...tissue, likely due to the metabolic effects of zinc in the Krebs cycle . That is, because zinc inhibits m- aconitase, loss of zinc allows for greater...secretory cells do not complete the oxidation of citrate in the mitochondria and the zinc-mediated inhibition of m-aconitase is crucial for the

A quantitative index of intracranial cerebrospinal fluid distribution in normal pressure hydrocephalus using an MRI-based processing technique.

PubMed

Tsunoda, A; Mitsuoka, H; Sato, K; Kanayama, S

2000-06-01

Our purpose was to quantify the intracranial cerebrospinal fluid (CSF) volume components using an original MRI-based segmentation technique and to investigate whether a CSF volume index is useful for diagnosis of normal pressure hydrocephalus (NPH). We studied 59 subjects: 16 patients with NPH, 14 young and 13 elderly normal volunteers, and 16 patients with cerebrovascular disease. Images were acquired on a 1.5-T system, using a 3D-fast asymmetrical spin-echo (FASE) method. A region-growing method (RGM) was used to extract the CSF spaces from the FASE images. Ventricular volume (VV) and intracranial CSF volume (ICV) were measured, and a VV/ICV ratio was calculated. Mean VV and VV/ICV ratio were higher in the NPH group than in the other groups, and the differences were statistically significant, whereas the mean ICV value in the NPH group was not significantly increased. Of the 16 patients in the NPH group, 13 had VV/ICV ratios above 30%. In contrast, no subject in the other groups had a VV/ICV ratios higher than 30%. We conclude that these CSF volume parameters, especially the VV/ICV ratio, are useful for the diagnosis of NPH.

Electrostatic, elastic and hydration-dependent interactions in dermis influencing volume exclusion and macromolecular transport.

PubMed

Øien, Alf H; Wiig, Helge

2016-07-07

Interstitial exclusion refers to the limitation of space available for plasma proteins and other macromolecules based on collagen and negatively charged glycosaminoglycans (GAGs) in the interstitial space. It is of particular importance to interstitial fluid and plasma volume regulation. Here we present a novel mechanical and mathematical model of the dynamic interactions of structural elements within the interstitium of the dermis at the microscopic level that may explain volume exclusion of charged and neutral macroparticles. At this level, the interstitium is considered to consist of elements called extracellular matrix (ECM) cells, again containing two main interacting structural components on a fluid background including anions and cations setting up osmotic forces: one smaller GAG component, having an intrinsic expansive electric force, and one bigger collagen component, having an intrinsic elastic force. Because of size differences, the GAG component interacts with a fraction of the collagen component only at normal hydration. This fraction, however, increases with rising hydration as a consequence of the modeled form of the interaction force between the GAGs and collagen. Collagen is locally displaced at variable degrees as hydration changes. Two models of GAGs are considered, having largely different geometries which demands different, but related, forms of GAG-collagen interaction forces. The effects of variable fixed charges on GAGs and of GAG density in tissue are evaluated taking into account observed volume exclusion properties of charged macromolecules as a function of tissue hydration. The presented models may improve our biophysical understanding of acting forces influencing tissue fluid dynamics. Such knowledge is significant when evaluating the transport of electrically charged and neutral macromolecules into and through the interstitium, and therefore to drug uptake and the therapeutic effects of macromolecular agents. Copyright © 2016 Elsevier Ltd. All rights reserved.

Aortic root dynamism, geometry, and function after the remodeling operation: Clinical relevance.

PubMed

Yacoub, Magdi H; Aguib, Heba; Gamrah, Mazen Abou; Shehata, Nairouz; Nagy, Mohamed; Donia, Mohamed; Aguib, Yasmine; Saad, Hesham; Romeih, Soha; Torii, Ryo; Afifi, Ahmed; Lee, Su-Lin

2018-04-13

Valve-conserving operations for aneurysms of the ascending aorta and root offer many advantages, and their use is steadily increasing. Optimizing the results of these operations depends on providing the best conditions for normal function and durability of the new root. Multimodality imaging including 2-dimensional echocardiography, multislice computed tomography, and cardiovascular magnetic resonance combined with image processing and computational fluid dynamics were used to define geometry, dynamism and aortic root function, before and after the remodeling operation. This was compared with 4 age-matched controls. The size and shape of the ascending aorta, aortic root, and its component parts showed considerable changes postoperatively, with preservation of dynamism. The postoperative size of the aortic annulus was reduced without the use of external bands or foreign material. Importantly, the elliptical shape of the annulus was maintained and changed during the cardiac cycle (Δ ellipticity index was 15% and 28% in patients 1 and 2, respectively). The "cyclic" area of the annulus changed in size (Δarea: 11.3% in patient 1 and 13.1% in patient 2). Functional analysis showed preserved reservoir function of the aortic root, and computational fluid dynamics demonstrated normalized pattern of flow in the ascending aorta, sinuses of Valsalva, and distal aorta. The remodeling operation results in near-normal geometry of the aortic root while maintaining dynamism of the aortic root and its components. This could have very important functional implications; the influence of these effects on both early- and long-term outcomes needs to be studied further. Copyright © 2018 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

Effects of poroelastic coefficients on normal vibration modes in vocal-fold tissues.

PubMed

Tao, Chao; Liu, Xiaojun

2011-02-01

The vocal-fold tissue is treated as a transversally isotropic fluid-saturated porous material. Effects of poroelastic coefficients on eigenfrequencies and eigenmodes of the vocal-fold vibration are investigated using the Ritz method. The study demonstrates that the often-used elastic model is only a particular case of the poroelastic model with an infinite fluid-solid mass coupling parameter. The elastic model may be considered appropriate for the vocal-fold tissue when the absolute value of the fluid-solid mass coupling parameter is larger than 10(5) kg/m(3). Otherwise, the poroelastic model may be more accurate. The degree of compressibility of the vocal tissue can also been described by the poroelastic coefficients. Finally, it is revealed that the liquid and solid components in a poroelastic model could have different modal shapes when the coupling between them is weak. The mode decoupling could cause desynchronization and irregular vibration of the folds.

Formaldehyde and some fully n-methylated substances in boar seminal fluids. Short communication.

PubMed

Szilágyi, M; Németh, Z I; Albert, L; Sarlós, P; Tyihák, E

2006-03-01

On the basis of recent observations it is supposed that seminal fluids may contain--mainly in hydroxymethyl groups--formaldehyde (HCHO) and quaternary ammonium compounds as potential HCHO generators, therefore, preliminary investigations were carried out for the identification of these compounds in pig seminal fluids using OPLC, HPLC and MALDI MS techniques. The fresh pig seminal fluid was frozen in liquid nitrogen, powdered and aliquots (0.25 g) were treated with 0.7 ml ethanolic dimedone solution. The suspension was centrifuged and the clear supernatant was used for analysis by OPLC or after dilution with HPLC or MALDI MS technique. After OPLC separation of formaldemethone the fully N-methylated compounds which are stayed on the start point were separated by OPLC using an other eluent system. It has been established that the HCHO is really a normal component of the pig seminal fluid, as well. It can be isolated and identified in dimedone adduct form. The measurable amount of HCHO depended on the concentration applied of dimedone. According to OPLC and MALDI MS investigations L-carnitine is the main quaternary ammonium compound in pig seminal fluid which can generate a protection of the sperm cells against environmental and other influences. Considerable differences have been found among individuals concerning concentrations of quaternary ammonium compounds in the seminal fluid of pigs.

Mutual-friction induced instability of normal-fluid vortex tubes in superfluid helium-4

NASA Astrophysics Data System (ADS)

Kivotides, Demosthenes

2018-06-01

It is shown that, as a result of its interactions with superfluid vorticity, a normal-fluid vortex tube in helium-4 becomes unstable and disintegrates. The superfluid vorticity acquires only a small (few percents of normal-fluid tube strength) polarization, whilst expanding in a front-like manner in the intervortex space of the normal-fluid, forming a dense, unstructured tangle in the process. The accompanied energy spectra scalings offer a structural explanation of analogous scalings in fully developed finite-temperature superfluid turbulence. A macroscopic mutual-friction model incorporating these findings is proposed.

Axial magnetic field and toroidally streaming fast ions in the dense plasma focus are natural consequences of conservation laws in the curved axisymmetric geometry of the current sheath. II. Towards a first principles theory

NASA Astrophysics Data System (ADS)

Auluck, S. K. H.

2017-11-01

This paper continues earlier discussion [S. K. H. Auluck, Phys. Plasmas 21, 102515 (2014)] concerning the formulation of conservation laws of mass, momentum, and energy in a local curvilinear coordinate system in the dense plasma focus. This formulation makes use of the revised Gratton-Vargas snowplow model [S. K. H. Auluck, Phys. Plasmas 20, 112501 (2013)], which provides an analytically defined imaginary surface in three dimensions which resembles the experimentally determined shape of the plasma. Unit vectors along the local tangent to this surface, along the azimuth, and along the local normal define a right-handed orthogonal local curvilinear coordinate system. The simplifying assumption that physical quantities have significant variation only along the normal enables writing laws of conservation of mass, momentum, and energy in the form of effectively one-dimensional hyperbolic conservation law equations using expressions for various differential operators derived for this coordinate system. This formulation demonstrates the highly non-trivial result that the axial magnetic field and toroidally streaming fast ions, experimentally observed by multiple prestigious laboratories, are natural consequences of conservation of mass, momentum, and energy in the curved geometry of the dense plasma focus current sheath. The present paper continues the discussion in the context of a 3-region shock structure similar to the one experimentally observed: an unperturbed region followed by a hydrodynamic shock containing some current followed by a magnetic piston. Rankine-Hugoniot conditions are derived, and expressions are obtained for the specific volumes and pressures using the mass-flux between the hydrodynamic shock and the magnetic piston and current fraction in the hydrodynamic shock as unknown parameters. For the special case of a magnetic piston that remains continuously in contact with the fluid being pushed, the theory gives closed form algebraic results for the fraction of current flowing in the hydrodynamic shock, specific volume, pressure, and fluid velocity of the hydrodynamic shock region, the tangential, normal, and azimuthal components of velocity in the magnetized plasma, the density of the magnetized plasma, the normal and tangential components of the magnetic field, and the tangential, normal, and azimuthal components of the electric field. This explains the occurrence of azimuthally streaming high energy deuterons experimentally observed by Frascati and Stuttgart. The expression derived for the azimuthal component of vector potential can serve as the basis for a proposed experimental test of the theory.

A Safe, Self-Calibrating, Wireless System for Measuring Volume of Any Fuel at Non-Horizontal Orientation

NASA Technical Reports Server (NTRS)

Woodward, Stanley E.; Taylor, Bryant D.

2010-01-01

A system for wirelessly measuring the volume of fluid in tanks at non-horizontal orientation is predicated upon two technologies developed at Langley Research Center. The first is a magnetic field response recorder that powers and interrogates magnetic field response sensors [ Magnetic Field Response Measurement Acquisition System, (LAR-16908), NASA Tech Briefs, Vol. 30, No. 6 (June 2006), page 28]. Magnetic field response sensors are a class of sensors that are powered via oscillating magnetic fields and when electrically active respond with their own magnetic fields whose attributes are dependent upon the magnitude of the physical quantity being measured. The response recorder facilitates the use of the second technology, which is a magnetic field response fluid-level sensor ["Wireless Fluid- Level Sensors for Harsh Environments," (LAR-17155), NASA Tech Briefs, Vol. 33, No. 4 (April 2009), page 30]. The method for powering and interrogating the sensors allows them to be completely encased in materials (Fig. 1) that are chemically resilient to the fluid being measured, thereby facilitating measurement of substances (e.g., acids, petroleum, cryogenic, caustic, and the like) that would normally destroy electronic circuitry. When the sensors are encapsulated, no fluid (or fluid vapor) is exposed to any electrical component of the measurement system. There is no direct electrical line from the vehicle or plant power into a fuel container. The means of interrogating and powering the sensors can be completely physically and electrically isolated from the fuel and vapors by placing the sensor on the other side of an electrically non-conductive bulkhead (Fig. 2). These features prevent the interrogation system and its electrical components from becoming an ignition source.

[Morphology of basement membrane and associated matrix proteins in normal and pathological tissues].

PubMed

Nerlich, A

1995-01-01

Basement membranes (BM) are specialized structures of the extracellular matrix. Their composition is of particular importance for the maintenance of normal morphological and functional properties of a multitude of organs and tissue systems and it is thus required for regular homeostasis of body function. Generally, they possess three main functions, i.e. participation in the maintenance of tissue structure, control of fluid and substrate exchange, and regulation of cell growth and differentiation. BMs are made up by various components which are in part specifically localized within the BM zone, or which represent ubiquitous matrix constituents with specific quantitative and/or qualitative differences in their localization. On the basis of a thorough immunohistochemical analysis of normal and diseased tissues, we provide here a concept of "functional morphology/pathomorphology" of the different BM components analyzed: 1.) The ubiquitous BM-constituent collagen IV primarily stabilizes the BM-zone and thus represents the "backbone" of the BM providing mechanical strength. Its loss leads to cystic tissue transformation as it is evidenced from the analysis of polycystic nephropathies. Thus, in other cystic tissue transformations a similar formal pathogenesis may be present. 2.) The specific localization of collagen VII as the main structural component of anchoring fibrils underlines the mechanical anchoring function of this collagenous protein. Defects in this protein lead to hereditary epidermolysis. The rapid re-occurrence of epidermal collagen VII during normal human wound healing indicates a quick reconstitution of the mechanical tensile strength of healing wounds. 3.) The BM-specific heparan sulfate proteoglycan (HSPG, Perlecan) with its highly negative anionic charge can be assumed to exert filter control. This assumption is corroborated by the localizatory findings of a preferential deposition of HSPG in endothelial and particularly in glomerular BM. Similarly, the lack of HSPG in the BM of lymph capillaries can be regarded as the correlate for a free fluid influx into lymphatic capillaries. The relative reduction in HSPG-staining in the developing glomerular BM also explains the still immature filter function. Furthermore, the low content of HSPG in placental chorionic capillaries can be regarded as morphological correlate for the required free fluid exchange between maternal and fetal blood systems. In diabetic glomerulopathy, the loss of HSPG coincides with a reduced filter function providing further support for the function of the HSPG. In further analyses of diabetic glomerulopathy, we provide evidence for an extensive matrix dysregulation resulting in either the overexpression of certain BM-components (diffuse glomerulosclerosis) or microfibrillar collagen VI (nodular glomerulosclerosis) indicating changes in cell function and possibly also cellular "differentiation". The analysis of congenital nephropathies additionally indicates that also the HSPG side chains with their negative charges may be involved in certain diseases with filter impairment. 4.) Furthermore, HSPG serves as a binding site for growth factors, particularly for the basic fibroblast growth factor (bFGF). It is of particular interest that the localization of HSPG and bFGF is not completely identical indicating some tissue specific differences in the receptor-ligand interaction. The functional importance of the bFGF-HSPG-interaction is exemplified by arteriosclerotic intima lesions where in highly cellular lesions high amounts of bFGF and HSPG coincide and low levels of both appear in poorly cellular lesions. Similarly, the granulation tissue in wound healing contains large amounts of bFGF-positive mesenchymal cells. 5.) The role of individual matrix components can be deduced from the normal human wound healing process, where epithelial cells migrate on a fibronectin matrix without complete BM.

Leveraging Understanding of Flow of Variable Complex Fluid to Design Better Absorbent Hygiene Products

NASA Astrophysics Data System (ADS)

Krautkramer, C.; Rend, R. R.

2014-12-01

Menstrual flow, which is a result of shedding of uterus endometrium, occurs periodically in sync with a women's hormonal cycle. Management of this flow while allowing women to pursue their normal daily lives is the purpose of many commercial products. Some of these products, e.g. feminine hygiene pads and tampons, utilize porous materials in achieving their goal. In this paper we will demonstrate different phenomena that have been observed in flow of menstrual fluid through these porous materials, share some of the advances made in experimental and analytical study of these phenomena, and also present some of the unsolved challenges and difficulties encountered while studying this kind of flow. Menstrual fluid is generally composed of four main components: blood plasma, blood cells, cervical mucus, and tissue debris. This non-homogeneous, multiphase fluid displays very complex rheological behavior, e. g., yield stress, thixotropy, and visco-elasticity, that varies throughout and between menstrual cycles and among women due to various factors. Flow rates are also highly variable during menstruation and across the population and the rheological properties of the fluid change during the flow into and through the product. In addition to these phenomena, changes to the structure of the porous medium within the product can also be seen due to fouling and/or swelling of the material. This paper will, also, share how the fluid components impact the flow and the consequences for computer simulation, the creation of a simulant fluid and testing methods, and for designing products that best meet consumer needs. We hope to bring to light the challenges of managing this complex flow to meet a basic need of women all over the world. An opportunity exists to apply learnings from research in other disciplines to improve the scientific knowledge related to the flow of this complex fluid through the porous medium that is a sanitary product.

Nonzero Ideal Gas Contribution to the Surface Tension of Water.

PubMed

Sega, Marcello; Fábián, Balázs; Jedlovszky, Pál

2017-06-15

Surface tension, the tendency of fluid interfaces to behave elastically and minimize their surface, is routinely calculated as the difference between the lateral and normal components of the pressure or, invoking isotropy in momentum space, of the virial tensor. Here we show that the anisotropy of the kinetic energy tensor close to a liquid-vapor interface can be responsible for a large part of its surface tension (about 15% for water, independent from temperature).

Cooling system for electronic components

DOEpatents

Anderl, William James; Colgan, Evan George; Gerken, James Dorance; Marroquin, Christopher Michael; Tian, Shurong

2015-12-15

Embodiments of the present invention provide for non interruptive fluid cooling of an electronic enclosure. One or more electronic component packages may be removable from a circuit card having a fluid flow system. When installed, the electronic component packages are coincident to and in a thermal relationship with the fluid flow system. If a particular electronic component package becomes non-functional, it may be removed from the electronic enclosure without affecting either the fluid flow system or other neighboring electronic component packages.

Cooling system for electronic components

DOEpatents

Anderl, William James; Colgan, Evan George; Gerken, James Dorance; Marroquin, Christopher Michael; Tian, Shurong

2016-05-17

Embodiments of the present invention provide for non interruptive fluid cooling of an electronic enclosure. One or more electronic component packages may be removable from a circuit card having a fluid flow system. When installed, the electronic component packages are coincident to and in a thermal relationship with the fluid flow system. If a particular electronic component package becomes non-functional, it may be removed from the electronic enclosure without affecting either the fluid flow system or other neighboring electronic component packages.

Analysis of a Panel of 48 Cytokines in BAL Fluids Specifically Identifies IL-8 Levels as the Only Cytokine that Distinguishes Controlled Asthma from Uncontrolled Asthma, and Correlates Inversely with FEV1

PubMed Central

Qi, Huibin; Kurosky, Alexander; Jennings, Kristofer; Sun, Qian; Boldogh, Istvan; Sur, Sanjiv

2015-01-01

We sought to identify cells and cytokines in bronchoalveolar lavage (BAL) fluids that distinguish asthma from healthy control subjects and those that distinguish controlled asthma from uncontrolled asthma. Following informed consent, 36 human subjects were recruited for this study. These included 11 healthy control subjects, 15 subjects with controlled asthma with FEV1≥80% predicted and 10 subjects with uncontrolled asthma with FEV1 <80% predicted. BAL fluid was obtained from all subjects. The numbers of different cell types and the levels of 48 cytokines were measured in these fluids. Compared to healthy control subjects, patients with asthma had significantly more percentages of eosinophils and neutrophils, IL-1RA, IL-1α, IL-1β, IL-2Rα, IL-5, IL-6, IL-7, IL-8, G-CSF, GROα (CXCL1), MIP-1β (CCL4), MIG (CXCL9), RANTES (CCL5) and TRAIL in their BAL fluids. The only inflammatory markers that distinguished controlled asthma from uncontrolled asthma were neutrophil percentage and IL-8 levels, and both were inversely correlated with FEV1. We examined whether grouping asthma subjects on the basis of BAL eosinophil % or neutrophil % could identify specific cytokine profiles. The only differences between neutrophil-normal asthma (neutrophil≤2.4%) and neutrophil-high asthma (neutrophils%>2.4%) were a higher BAL fluid IL-8 levels, and a lower FEV1 in the latter group. By contrast, compared to eosinophil-normal asthma (eosinophils≤0.3%), eosinophil-high asthma (eosinophils>0.3%) had higher levels of IL-5, IL-13, IL-16, and PDGF-bb, but same neutrophil percentage, IL-8, and FEV1. Our results identify neutrophils and IL-8 are the only inflammatory components in BAL fluids that distinguish controlled asthma from uncontrolled asthma, and both correlate inversely with FEV1. PMID:26011707

Tracing subduction zone fluid-rock interactions using trace element and Mg-Sr-Nd isotopes

NASA Astrophysics Data System (ADS)

Wang, Shui-Jiong; Teng, Fang-Zhen; Li, Shu-Guang; Zhang, Li-Fei; Du, Jin-Xue; He, Yong-Sheng; Niu, Yaoling

2017-10-01

Slab-derived fluids play a key role in mass transfer and elemental/isotopic exchanges in subduction zones. The exhumation of deeply subducted crust is achieved via a subduction channel where fluids from various sources are abundant, and thus the chemical/isotopic compositions of these rocks could have been modified by subduction-zone fluid-rock interactions. Here, we investigate the Mg isotopic systematics of eclogites from southwestern Tianshan, in conjunction with major/trace element and Sr-Nd isotopes, to characterize the source and nature of fluids and to decipher how fluid-rock interactions in subduction channel might influence the Mg isotopic systematics of exhumed eclogites. The eclogites have high LILEs (especially Ba) and Pb, high initial 87Sr/86Sr (up to 0.7117; higher than that of coeval seawater), and varying Ni and Co (mostly lower than those of oceanic basalts), suggesting that these eclogites have interacted with metamorphic fluids mainly released from subducted sediments, with minor contributions from altered oceanic crust or altered abyssal peridotites. The positive correlation between 87Sr/86Sr and Pb* (an index of Pb enrichment; Pb* = 2*PbN/[CeN + PrN]), and the decoupling relationships and bidirectional patterns in 87Sr/86Sr-Rb/Sr, Pb*-Rb/Sr and Pb*-Ba/Pb spaces imply the presence of two compositionally different components for the fluids: one enriched in LILEs, and the other enriched in Pb and 87Sr/86Sr. The systematically heavier Mg isotopic compositions (δ26Mg = - 0.37 to + 0.26) relative to oceanic basalts (- 0.25 ± 0.07) and the roughly negative correlation of δ26Mg with MgO for the southwestern Tianshan eclogites, cannot be explained by inheritance of Mg isotopic signatures from ancient seafloor alteration or prograde metamorphism. Instead, the signatures are most likely produced by fluid-rock interactions during the exhumation of eclogites. The high Rb/Sr and Ba/Pb but low Pb* eclogites generally have high bulk-rock δ26Mg values, whereas high Pb* and 87Sr/86Sr eclogites have mantle-like δ26Mg values, suggesting that the two fluid components have diverse influences on the Mg isotopic systematics of these eclogites. The LILE-rich fluid component, possibly derived from mica-group minerals, contains a considerable amount of isotopically heavy Mg that has shifted the δ26Mg of the eclogites towards higher values. By contrast, the 87Sr/86Sr- and Pb-rich fluid component, most likely released from epidote-group minerals in metasediments, has little Mg so as not to modify the Mg isotopic composition of the eclogites. In addition, the influence of talc-derived fluid might be evident in a very few eclogites that have low Rb/Sr and Ba/Pb but slightly heavier Mg isotopic compositions. These findings represent an important step toward a broad understanding of the Mg isotope geochemistry in subduction zones, and contributing to understanding why island arc basalts have averagely heavier Mg isotopic compositions than the normal mantle.

FLUID-STRUCTURE INTERACTION MODELS OF THE MITRAL VALVE: FUNCTION IN NORMAL AND PATHOLOGIC STATES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kunzelman, K. S.; Einstein, Daniel R.; Cochran, R. P.

2007-08-29

Successful mitral valve repair is dependent upon a full understanding of normal and abnormal mitral valve anatomy and function. Computational analysis is one such method that can be applied to simulate mitral valve function in order to analyze the roles of individual components, and evaluate proposed surgical repair. We developed the first three-dimensional, finite element (FE) computer model of the mitral valve including leaflets and chordae tendineae, however, one critical aspect that has been missing until the last few years was the evaluation of fluid flow, as coupled to the function of the mitral valve structure. We present here ourmore » latest results for normal function and specific pathologic changes using a fluid-structure interaction (FSI) model. Normal valve function was first assessed, followed by pathologic material changes in collagen fiber volume fraction, fiber stiffness, fiber splay, and isotropic stiffness. Leaflet and chordal stress and strain, and papillary muscle force was determined. In addition, transmitral flow, time to leaflet closure, and heart valve sound were assessed. Model predictions in the normal state agreed well with a wide range of available in-vivo and in-vitro data. Further, pathologic material changes that preserved the anisotropy of the valve leaflets were found to preserve valve function. By contrast, material changes that altered the anisotropy of the valve were found to profoundly alter valve function. The addition of blood flow and an experimentally driven microstructural description of mitral tissue represent significant advances in computational studies of the mitral valve, which allow further insight to be gained. This work is another building block in the foundation of a computational framework to aid in the refinement and development of a truly noninvasive diagnostic evaluation of the mitral valve. Ultimately, it represents the basis for simulation of surgical repair of pathologic valves in a clinical and educational setting.« less

The physical signs of impending dehydration among elderly people in nursing homes: The association with axillary skin temperature, humidity, intraoral moisture content, and salivary components.

PubMed

Okuyama, Mayumi; Nishida, Masumi

2016-01-01

The aim of the present study was to examine the association between impending dehydration among elderly people in nursing homes and physical signs, including the axillary skin temperature, humidity, intraoral moisture content, and salivary components. The study included 78 elderly individuals who required long-term care in a nursing home (11 men and 67 women; average age, 86.6±7.3 years). The elderly subjects were classified in two groups according to their serum osmolality levels: those with levels between the upper limit reference value (292 mOsm/kg H2O) and the diagnostic reference value of dehydration (300 mOsm/kg H2O) were classified into the boundary zone group and those with levels of <292 mOsm/kg H2O were classified into the normal range group. The following parameters were measured: basic attributes (age, gender and level of care required), body mass index, diet, daily fluid intake per kilogram of body weight, physiological indicators (blood pressure, pulse rate, body temperature, axillary skin temperature, humidity, total body water, body water rate, internal liquid rate, external solution rate, blood components, intraoral water amount, and salivary components), and the indoor environment (room temperature and humidity). We then performed a statistical analysis to compare the boundary zone group with the normal range group. After adjusting for age and the daily fluid intake per kilogram of body weight (<25 ml/≥25 ml), we performed a logistic regression analysis (the boundary zone group was used as an independent variable) for variables that had significance levels of <0.05 (except for blood components). The univariate analysis revealed significant differences in the following parameters: the serum sodium, chloride, and creatinine levels; the blood sugar level; the urea nitrogen/creatinine ratio; the axillary skin temperature; and room humidity. Only the axillary skin temperature showed a significant association in the final model of the logistic regression analysis (odds ratio, 3.664; 95% confidence interval, 1.101-12.197; p = 0.034). As the axillary skin temperature increased by 1°C, there was a 3.67-fold risk of being classified into the boundary zone group instead of the normal range group. Thus, the axillary skin temperature was associated with impending dehydration.

21 CFR 882.5550 - Central nervous system fluid shunt and components.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

21 CFR 882.5550 - Central nervous system fluid shunt and components.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

21 CFR 882.5550 - Central nervous system fluid shunt and components.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

21 CFR 882.5550 - Central nervous system fluid shunt and components.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

21 CFR 882.5550 - Central nervous system fluid shunt and components.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

High gliding fluid power generation system with fluid component separation and multiple condensers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahmoud, Ahmad M; Lee, Jaeseon; Radcliff, Thomas D

2014-10-14

An example power generation system includes a vapor generator, a turbine, a separator and a pump. In the separator, the multiple components of the working fluid are separated from each other and sent to separate condensers. Each of the separate condensers is configured for condensing a single component of the working fluid. Once each of the components condense back into a liquid form they are recombined and exhausted to a pump that in turn drives the working fluid back to the vapor generator.

Integrated reactor and centrifugal separator and uses thereof

DOEpatents

Birdwell, Jr., Joseph F; Jennings, Harold L [Clinton, TN; McFarlane, Joanna [Oak Ridge, TN; Tsouris, Constantino [Oak Ridge, TN

2012-01-17

An apparatus for providing reaction of fluids and separation of products with increased residence time. The apparatus includes a stationary shell, a rotating hollow cylindrical component disposed in the stationary shell, a residence-time increasing device external to the stationary shell, a standpipe for introducing fluid into an interior cavity of the hollow cylindrical component from the residence-time increasing device, a first outlet in fluid flow communication with the interior cavity of the hollow cylindrical component for a less dense phase fluid, and a second outlet in fluid flow communication with the interior cavity of the hollow cylindrical component for a more dense phase fluid.

Three-Dimensional Coupled Dynamics of The Two-Fluid Model in Superfluid 4He: Deformed Velocity Profile of Normal Fluid in Thermal Counterflow

NASA Astrophysics Data System (ADS)

Yui, Satoshi; Tsubota, Makoto; Kobayashi, Hiromichi

2018-04-01

The coupled dynamics of the two-fluid model of superfluid 4He is numerically studied for quantum turbulence of the thermal counterflow in a square channel. We combine the vortex filament model of the superfluid and the Navier-Stokes equations of normal fluid. Simulations of the coupled dynamics show that the velocity profile of the normal fluid is deformed significantly by superfluid turbulence as the vortices become dense. This result is consistent with recently performed visualization experiments. We introduce a dimensionless parameter that characterizes the deformation of the velocity profile.

Drinking water in traditional Persian medicine: Do’s and don’ts

PubMed Central

Nimrouzi, Majid; Daneshfard, Babak

2017-01-01

Water is the main component of our body and its balance is vital for maintaining normal physiology. Accordingly, adequate fluid intake in the daily diet is very important for a healthy life. Nevertheless, there is a controversy about what the suitable amount of water that we need to drink is. In this paper, we aimed to discuss this important issue based on the doctrine of traditional Persian medicine (TPM) and our clinical experience in a practical manner. PMID:28713503

Statefinder analysis of the superfluid Chaplygin gas model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Popov, V.A., E-mail: vladipopov@mail.ru

2011-10-01

The statefinder indices are employed to test the superfluid Chaplygin gas (SCG) model describing the dark sector of the universe. The model involves Bose-Einstein condensate (BEC) as dark energy (DE) and an excited state above it as dark matter (DM). The condensate is assumed to have a negative pressure and is embodied as an exotic fluid with the Chaplygin equation of state. Excitations forms the normal component of superfluid. The statefinder diagrams show the discrimination between the SCG scenario and other models with the Chaplygin gas and indicates a pronounced effect of the DM equation of state and an indirectmore » interaction between their two components on statefinder trajectories and a current statefinder location.« less

Statefinder analysis of the superfluid Chaplygin gas model

NASA Astrophysics Data System (ADS)

Popov, V. A.

2011-10-01

The statefinder indices are employed to test the superfluid Chaplygin gas (SCG) model describing the dark sector of the universe. The model involves Bose-Einstein condensate (BEC) as dark energy (DE) and an excited state above it as dark matter (DM). The condensate is assumed to have a negative pressure and is embodied as an exotic fluid with the Chaplygin equation of state. Excitations forms the normal component of superfluid. The statefinder diagrams show the discrimination between the SCG scenario and other models with the Chaplygin gas and indicates a pronounced effect of the DM equation of state and an indirect interaction between their two components on statefinder trajectories and a current statefinder location.

Partitioning of Large-ion Lithophile Elements Between Aqueous Fluids and Melts: Role of Saline Fluids in Sub-arc Mantle

NASA Astrophysics Data System (ADS)

Kawamoto, T.; Mibe, K.

2014-12-01

Chemical fractionation of slab-derived supercritical fluids can play an important role in elemental transfer from subducting slab to the mantle wedge and arc magmatism [1]. Recent findings of saline fluids from sub-arc mantle peridotite indicate that aqueous fluids in mantle wedge can contain 3.7 wt% NaCl in Ichinomageta, Northeast Japan arc [2] to 5.1 wt% NaCl in Pinatubo, Luzon arc [3]. It is, therefore, important to determine the effect of Cl on the trace element partitioning between aqueous fluids and melts. Synchrotron radiation X-ray fluorescence (XRF) analysis is conducted to know Rb, Sr, and Pb partitioning between aqueous fluids and melts [4]. There is a positive correlation between partition coefficients and pressure, as well as salinity. Two slab-derived components, melt and fluid components, are suggested to explain trace element characteristics of arc-basalts in the Mariana arc [5]. The fluid component is characterized by enrichment of alkali and alkali earth elements. Such features can be explained if the fluid component is a saline fluid, because alkali earth elements and Pb are much less mobile with Cl-free fluids than Cl-rich fluids [4]. We suggest that slab-derived components have compositional features consistent with a saline fluid and a melt, which can be formed through a separation of a slab-derived supercritical fluid [1]. Slab derived supercritical fluids contain Cl, and aqueous fluids inherit much of the Cl and some of the large-ion lithophile elements. [1] Kawamoto et al. 2012, Separation of supercritical slab-fluids to form aqueous fluid and melt components in subduction zone magmatism. PNAS, pnas.org/content/109/46/18695 [2] Kumagai et al. Evolution of carbon dioxide bearing saline fluids in the mantle wedge beneath the Northeast Japan arc, CMP [3] Kawamoto et al. 2013, Mantle wedge infiltrated with saline fluids from dehydration and decarbonation of subducting slab. PNAS, pnas.org/content/110/24/9663 [4] Kawamoto et al. 2014, Large ion lithophile elements delivered by saline fluids to the sub-arc mantle, EPS, earth-planets-space.com/content/66/1/61 [5] Pearce et al. 2005, Geochemical mapping of the Mariana arc-basin system: Implications for the nature and distribution of subduction components. G-cubed, onlinelibrary.wiley.com/doi/10.1029/2004GC000895/full

Strongly coupled fluid-particle flows in vertical channels. I. Reynolds-averaged two-phase turbulence statistics

NASA Astrophysics Data System (ADS)

Capecelatro, Jesse; Desjardins, Olivier; Fox, Rodney O.

2016-03-01

Simulations of strongly coupled (i.e., high-mass-loading) fluid-particle flows in vertical channels are performed with the purpose of understanding the fundamental physics of wall-bounded multiphase turbulence. The exact Reynolds-averaged (RA) equations for high-mass-loading suspensions are presented, and the unclosed terms that are retained in the context of fully developed channel flow are evaluated in an Eulerian-Lagrangian (EL) framework for the first time. A key distinction between the RA formulation presented in the current work and previous derivations of multiphase turbulence models is the partitioning of the particle velocity fluctuations into spatially correlated and uncorrelated components, used to define the components of the particle-phase turbulent kinetic energy (TKE) and granular temperature, respectively. The adaptive spatial filtering technique developed in our previous work for homogeneous flows [J. Capecelatro, O. Desjardins, and R. O. Fox, "Numerical study of collisional particle dynamics in cluster-induced turbulence," J. Fluid Mech. 747, R2 (2014)] is shown to accurately partition the particle velocity fluctuations at all distances from the wall. Strong segregation in the components of granular energy is observed, with the largest values of particle-phase TKE associated with clusters falling near the channel wall, while maximum granular temperature is observed at the center of the channel. The anisotropy of the Reynolds stresses both near the wall and far away is found to be a crucial component for understanding the distribution of the particle-phase volume fraction. In Part II of this paper, results from the EL simulations are used to validate a multiphase Reynolds-stress turbulence model that correctly predicts the wall-normal distribution of the two-phase turbulence statistics.

Strongly coupled fluid-particle flows in vertical channels. I. Reynolds-averaged two-phase turbulence statistics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Capecelatro, Jesse, E-mail: jcaps@illinois.edu; Desjardins, Olivier; Fox, Rodney O.

Simulations of strongly coupled (i.e., high-mass-loading) fluid-particle flows in vertical channels are performed with the purpose of understanding the fundamental physics of wall-bounded multiphase turbulence. The exact Reynolds-averaged (RA) equations for high-mass-loading suspensions are presented, and the unclosed terms that are retained in the context of fully developed channel flow are evaluated in an Eulerian–Lagrangian (EL) framework for the first time. A key distinction between the RA formulation presented in the current work and previous derivations of multiphase turbulence models is the partitioning of the particle velocity fluctuations into spatially correlated and uncorrelated components, used to define the components ofmore » the particle-phase turbulent kinetic energy (TKE) and granular temperature, respectively. The adaptive spatial filtering technique developed in our previous work for homogeneous flows [J. Capecelatro, O. Desjardins, and R. O. Fox, “Numerical study of collisional particle dynamics in cluster-induced turbulence,” J. Fluid Mech. 747, R2 (2014)] is shown to accurately partition the particle velocity fluctuations at all distances from the wall. Strong segregation in the components of granular energy is observed, with the largest values of particle-phase TKE associated with clusters falling near the channel wall, while maximum granular temperature is observed at the center of the channel. The anisotropy of the Reynolds stresses both near the wall and far away is found to be a crucial component for understanding the distribution of the particle-phase volume fraction. In Part II of this paper, results from the EL simulations are used to validate a multiphase Reynolds-stress turbulence model that correctly predicts the wall-normal distribution of the two-phase turbulence statistics.« less

Choice of fluid therapy in patients of craniopharyngioma in the perioperative period: A hospital-based preliminary study

PubMed Central

Mukherjee, K. K.; Dutta, Pinaki; Singh, Apinderpreet; Gupta, Prakamya; Srinivasan, Anand; Bhagat, Hemant; Mathuriya, S. N.; Shah, Viral N.; Bhansali, Anil

2014-01-01

Background: Electrolyte imbalance and acute diabetes insipidus (DI) are the most common complications in patients undergoing craniopharyngioma surgery. Improper management of water and electrolyte imbalance is common cause of morbidity and mortality. Data is sparse and controversial regarding the choice of fluid therapy in this population during perioperative period. Methods: In this retrospective-prospective study involving 73 patients (58 retrospective), the type of fluid therapy was correlated with occurrence of hypernatremia, hyponatremia, DI, morbidity, and mortality. In the retrospective study, 48 patients received normal saline and 10 received mixed fluids as per the prevailing practice. In the prospective group, five patients each received normal saline, half normal saline, and 5% dextrose randomly. Results: The sodium values were significantly higher in first 48 h in the group that received normal saline compared with other groups (P < 0.001). The use of normal saline was associated with higher incidence of hypernatremia, DI, and mortality (P = 0.05), while the group that received 5% dextrose was associated with hyponatremia, hypoglycemia, and seizures. There was no perioperative hypotension with use of any of the fluids. Conclusion: Our results indicate half normal saline was fluid of choice with diminished incidence of water and electrolyte abnormalities without increase in mortality during postoperative period. PMID:25101200

Fluid and electrolyte disturbances in critically ill patients.

PubMed

Lee, Jay Wook

2010-12-01

Disturbances in fluid and electrolytes are among the most common clinical problems encountered in the intensive care unit (ICU). Recent studies have reported that fluid and electrolyte imbalances are associated with increased morbidity and mortality among critically ill patients. To provide optimal care, health care providers should be familiar with the principles and practice of fluid and electrolyte physiology and pathophysiology. Fluid resuscitation should be aimed at restoration of normal hemodynamics and tissue perfusion. Early goal-directed therapy has been shown to be effective in patients with severe sepsis or septic shock. On the other hand, liberal fluid administration is associated with adverse outcomes such as prolonged stay in the ICU, higher cost of care, and increased mortality. Development of hyponatremia in critically ill patients is associated with disturbances in the renal mechanism of urinary dilution. Removal of nonosmotic stimuli for vasopressin secretion, judicious use of hypertonic saline, and close monitoring of plasma and urine electrolytes are essential components of therapy. Hypernatremia is associated with cellular dehydration and central nervous system damage. Water deficit should be corrected with hypotonic fluid, and ongoing water loss should be taken into account. Cardiac manifestations should be identified and treated before initiating stepwise diagnostic evaluation of dyskalemias. Divalent ion deficiencies such as hypocalcemia, hypomagnesemia and hypophosphatemia should be identified and corrected, since they are associated with increased adverse events among critically ill patients.

Second-trimester IL-15 and IL-18 levels in the amniotic fluid of fetuses with normal karyotypes and with chromosome abnormalities.

PubMed

Klimkiewicz-Blok, Dominika; Florjański, Jerzy; Zalewski, Jerzy; Blok, Radosław

2012-01-01

Little is known about the behavior of interleukin 15 (IL-15) and 18 (IL-18) in the amniotic fluid in the second trimester of gestations complicated by chromosomal defects in the fetus. Likewise, it has not yet been established whether a fetus with chromosome abnormalities creates its immunity mechanisms in the same way as a fetus with a normal karyotype. The aim of this work was to assess the concentration of IL-15 and IL-18 in the amniotic fluid in the second trimester of gestation in fetuses with normal karyotypes and with chromosome abnormalities. The material consisted of 51 samples of amniotic fluid obtained from genetic amniocenteses carried out between the 15th and the 19th weeks of gestation. On the basis of cytogenetic screening, two groups were singled out: Group I--45 fetuses with normal karyotypes, and Group II--6 fetuses with abnormal karyotypes. The concentrations of IL-15 and IL-18 in the amniotic fluid were assessed with ready-made assays and analyzed, and the results from both groups were compared. The differences between the IL-15 levels in the amniotic fluid from Groups I and II proved to be statistically insignificant (p = 0.054). However, the average IL-18 levels in the amniotic fluid of the fetuses with normal karyotypes were significantly higher than in the amniotic fluid of the fetuses with chromosome abnormalities (p = 0.032). Some defense mechanisms in the second trimester of gestation in fetuses with chromosome abnormalities may develop in a different way than in fetuses with normal karyotypes.

Thermal Analysis System

NASA Technical Reports Server (NTRS)

DiStefano, III, Frank James (Inventor); Wobick, Craig A. (Inventor); Chapman, Kirt Auldwin (Inventor); McCloud, Peter L. (Inventor)

2014-01-01

A thermal fluid system modeler including a plurality of individual components. A solution vector is configured and ordered as a function of one or more inlet dependencies of the plurality of individual components. A fluid flow simulator simulates thermal energy being communicated with the flowing fluid and between first and second components of the plurality of individual components. The simulation extends from an initial time to a later time step and bounds heat transfer to be substantially between the flowing fluid, walls of tubes formed in each of the individual components of the plurality, and between adjacent tubes. Component parameters of the solution vector are updated with simulation results for each of the plurality of individual components of the simulation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

A system for removing components of a gaseous mixture is provided comprising: a reactor fluid containing vessel having conduits extending therefrom, aqueous fluid within the reactor, the fluid containing a ligand and a metal, and at least one reactive surface within the vessel coupled to a power source. A method for removing a component from a gaseous mixture is provided comprising exposing the gaseous mixture to a fluid containing a ligand and a reactive metal, the exposing chemically binding the component of the gaseous mixture to the ligand. A method of capturing a component of a gaseous mixture is providedmore » comprising: exposing the gaseous mixture to a fluid containing a ligand and a reactive metal, the exposing chemically binding the component of the gaseous mixture to the ligand, altering the oxidation state of the metal, the altering unbinding the component from the ligand, and capturing the component.« less

Energy and angular momentum balance in wall-bounded quantum turbulence at very low temperatures.

PubMed

Hosio, J J; Eltsov, V B; Heikkinen, P J; Hänninen, R; Krusius, M; L'vov, V S

2013-01-01

A superfluid in the absence of a viscous normal component should be the best realization of an ideal inviscid Euler fluid. As expressed by d'Alembert's famous paradox, an ideal fluid does not drag on bodies past which it flows, or in other words it does not exchange momentum with them. In addition, the flow of an ideal fluid does not dissipate kinetic energy. Here we study experimentally whether these properties apply to the flow of superfluid (3)He-B in a rotating cylinder at low temperatures. It is found that ideal behaviour is broken by quantum turbulence, which leads to substantial energy dissipation, as was also observed earlier. Remarkably, the angular momentum exchange between the superfluid and its container approaches nearly ideal behaviour, as the drag almost disappears in the zero-temperature limit. Here the mismatch between energy and angular momentum transfer results in a new physical situation, with severe implications on the flow dynamics.

Interface equation and viscosity contrast in Hele-Shaw flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casademunt, J.; Jasnow, D.; Hernandez-Machado, A.

1992-05-20

In this paper, the authors derive an integro-differential equation for the evolution of the interface separating two immiscible viscous fluids in a Hele-Shaw cell with a channel geometry, for arbitrary viscosity contrast. The authors' equation differs from a previous one obtained by a vortex-sheet formulation of the problem, in that the normal component of the interface velocity is formally decoupled from the gauge-dependent tangential part. The result is thus a closed integral equation for the normal velocity. The authors briefly comment on the advantages of such a formulation and implement an alternative computational algorithm based on it. Preliminary numerical resultsmore » confirm a highly inefficient finger competition in the zero viscosity contrast limit.« less

Fluid involvement in normal faulting

NASA Astrophysics Data System (ADS)

Sibson, Richard H.

2000-04-01

Evidence of fluid interaction with normal faults comes from their varied role as flow barriers or conduits in hydrocarbon basins and as hosting structures for hydrothermal mineralisation, and from fault-rock assemblages in exhumed footwalls of steep active normal faults and metamorphic core complexes. These last suggest involvement of predominantly aqueous fluids over a broad depth range, with implications for fault shear resistance and the mechanics of normal fault reactivation. A general downwards progression in fault rock assemblages (high-level breccia-gouge (often clay-rich) → cataclasites → phyllonites → mylonite → mylonitic gneiss with the onset of greenschist phyllonites occurring near the base of the seismogenic crust) is inferred for normal fault zones developed in quartzo-feldspathic continental crust. Fluid inclusion studies in hydrothermal veining from some footwall assemblages suggest a transition from hydrostatic to suprahydrostatic fluid pressures over the depth range 3-5 km, with some evidence for near-lithostatic to hydrostatic pressure cycling towards the base of the seismogenic zone in the phyllonitic assemblages. Development of fault-fracture meshes through mixed-mode brittle failure in rock-masses with strong competence layering is promoted by low effective stress in the absence of thoroughgoing cohesionless faults that are favourably oriented for reactivation. Meshes may develop around normal faults in the near-surface under hydrostatic fluid pressures to depths determined by rock tensile strength, and at greater depths in overpressured portions of normal fault zones and at stress heterogeneities, especially dilational jogs. Overpressures localised within developing normal fault zones also determine the extent to which they may reutilise existing discontinuities (for example, low-angle thrust faults). Brittle failure mode plots demonstrate that reactivation of existing low-angle faults under vertical σ1 trajectories is only likely if fluid overpressures are localised within the fault zone and the surrounding rock retains significant tensile strength. Migrating pore fluids interact both statically and dynamically with normal faults. Static effects include consideration of the relative permeability of the faults with respect to the country rock, and juxtaposition effects which determine whether a fault is transmissive to flow or acts as an impermeable barrier. Strong directional permeability is expected in the subhorizontal σ2 direction parallel to intersections between minor faults, extension fractures, and stylolites. Three dynamic mechanisms tied to the seismic stress cycle may contribute to fluid redistribution: (i) cycling of mean stress coupled to shear stress, sometimes leading to postfailure expulsion of fluid from vertical fractures; (ii) suction pump action at dilational fault jogs; and, (iii) fault-valve action when a normal fault transects a seal capping either uniformly overpressured crust or overpressures localised to the immediate vicinity of the fault zone at depth. The combination of σ2 directional permeability with fluid redistribution from mean stress cycling may lead to hydraulic communication along strike, contributing to the protracted earthquake sequences that characterise normal fault systems.

Atomic Force Microscope Mediated Chromatography

NASA Technical Reports Server (NTRS)

Anderson, Mark S.

2013-01-01

The atomic force microscope (AFM) is used to inject a sample, provide shear-driven liquid flow over a functionalized substrate, and detect separated components. This is demonstrated using lipophilic dyes and normal phase chromatography. A significant reduction in both size and separation time scales is achieved with a 25-micron-length column scale, and one-second separation times. The approach has general applications to trace chemical and microfluidic analysis. The AFM is now a common tool for ultra-microscopy and nanotechnology. It has also been demonstrated to provide a number of microfluidic functions necessary for miniaturized chromatography. These include injection of sub-femtoliter samples, fluidic switching, and sheardriven pumping. The AFM probe tip can be used to selectively remove surface layers for subsequent microchemical analysis using infrared and tip-enhanced Raman spectroscopy. With its ability to image individual atoms, the AFM is a remarkably sensitive detector that can be used to detect separated components. These diverse functional components of microfluidic manipulation have been combined in this work to demonstrate AFM mediated chromatography. AFM mediated chromatography uses channel-less, shear-driven pumping. This is demonstrated with a thin, aluminum oxide substrate and a non-polar solvent system to separate a mixture of lipophilic dyes. In conventional chromatographic terms, this is analogous to thin-layer chromatography using normal phase alumina substrate with sheardriven pumping provided by the AFM tip-cantilever mechanism. The AFM detection of separated components is accomplished by exploiting the variation in the localized friction of the separated components. The AFM tip-cantilever provides the mechanism for producing shear-induced flows and rapid pumping. Shear-driven chromatography (SDC) is a relatively new concept that overcomes the speed and miniaturization limitations of conventional liquid chromatography. SDC is based on a sliding plate system, consisting of two flat surfaces, one of which has a recessed channel. A fluid flow is produced by axially sliding one plate past another, where the fluid has mechanical shear forces imposed at each point along the channel length. The shear-induced flow rates are very reproducible, and do not have pressure or voltage gradient limitations. SDC opens up a new range of enhanced separation kinetics by permitting the sample confinement with submicron dimensions. Small, highly confined liquid is advantageous for chromatographic separation because the separation rate is known to scale according to the square of the confined sample diameter. In addition, because shear-driven flows are not limited by fluid velocity, shear-driven liquid chromatography may provide up to 100,000 plate efficiency.

Intra-operative on-line discrimination of kidney cancer from normal tissue by IR ATR spectroscopy of extracellular fluid

NASA Astrophysics Data System (ADS)

Urboniene, V.; Velicka, M.; Ceponkus, J.; Pucetaite, M.; Jankevicius, F.; Sablinskas, V.; Steiner, G.

2016-03-01

Determination of cancerous and normal kidney tissues during partial, simple or radical nephrectomy surgery was performed by using differences in the IR absorption spectra of extracellular fluid taken from the corresponding tissue areas. The samples were prepared by stamping of the kidney tissue on ATR diamond crystal. The spectral measurements were performed directly in the OR during surgery for 58 patients. It was found that intensities of characteristic spectral bands of glycogen (880-1200 cm-1) in extracellular fluid are sensitive to the type of the tissue and can be used as spectral markers of tumours. Characteristic spectral band of lactic acid (1730 cm-1) - product of the anaerobic glycolysis, taking place in the cancer cells is not suitable for use as a spectral marker of cancerous tissue, since it overlaps with the band of carbonyl stretch in phospholipids and fatty acids. Results of hierarchical cluster analysis of the spectra show that the spectra of healthy and tumour tissue films can be reliably separated into two groups. On the other hand, possibility to differentiate between tumours of different types and grades remains in question. While the fluid from highly malignant G3 tumour tissue contains highly pronounced glycogen spectral bands and can be well separated from benign and G1 tumours by principal component analysis, the variations between spectra from sample to sample prevent from obtaining conclusive results about the grouping between different tumour types and grades. The proposed method is instant and can be used in situ and even in vivo.

Internal structure, fault rocks, and inferences regarding deformation, fluid flow, and mineralization in the seismogenic Stillwater normal fault, Dixie Valley, Nevada

USGS Publications Warehouse

Caine, Jonathan S.; Bruhn, R.L.; Forster, C.B.

2010-01-01

Outcrop mapping and fault-rock characterization of the Stillwater normal fault zone in Dixie Valley, Nevada are used to document and interpret ancient hydrothermal fluid flow and its possible relationship to seismic deformation. The fault zone is composed of distinct structural and hydrogeological components. Previous work on the fault rocks is extended to the map scale where a distinctive fault core shows a spectrum of different fault-related breccias. These include predominantly clast-supported breccias with angular clasts that are cut by zones containing breccias with rounded clasts that are also clast supported. These are further cut by breccias that are predominantly matrix supported with angular and rounded clasts. The fault-core breccias are surrounded by a heterogeneously fractured damage zone. Breccias are bounded between major, silicified slip surfaces, forming large pod-like structures, systematically oriented with long axes parallel to slip. Matrix-supported breccias have multiply brecciated, angular and rounded clasts revealing episodic deformation and fluid flow. These breccias have a quartz-rich matrix with microcrystalline anhedral, equant, and pervasively conformable mosaic texture. The breccia pods are interpreted to have formed by decompression boiling and rapid precipitation of hydrothermal fluids whose flow was induced by coseismic, hybrid dilatant-shear deformation and hydraulic connection to a geothermal reservoir. The addition of hydrothermal silica cement localized in the core at the map scale causes fault-zone widening, local sealing, and mechanical heterogeneities that impact the evolution of the fault zone throughout the seismic cycle. ?? 2010.

ERPs evidence for the relationship between fluid intelligence and cognitive control.

PubMed

Lu, Di; Zhang, Haoyun; Kang, Chunyan; Guo, Taomei

2016-04-13

The relationship between two components of cognitive control, that is, proactive control and reactive control, and fluid intelligence was investigated by measuring 75 participants' event-related potentials in the AX version of the continuous performance test. The results showed that the mean amplitudes of N2 associated with the two components of cognitive control are highly correlated with fluid intelligence. Specifically, a larger N2 was shown in participants with higher fluid intelligence scores. No significant correlation was found in the peak latencies of the N2 and fluid intelligence. These results enrich our understanding of the relationship between cognitive control and fluid intelligence by using the N2 component as an index and also indicate that cognitive control may be a component of intelligence.

Spectral luminescence analysis of amniotic fluid

NASA Astrophysics Data System (ADS)

Slobozhanina, Ekaterina I.; Kozlova, Nataly M.; Kasko, Leonid P.; Mamontova, Marina V.; Chernitsky, Eugene A.

1997-12-01

It is shown that the amniotic fluid has intensive ultra-violet luminescence caused by proteins. Along with it amniotic fluid radiated in the field of 380 - 650 nm with maxima at 430 - 450 nm and 520 - 560 nm. The first peak of luminescence ((lambda) exc equals 350 nm; (lambda) em equals 430 - 440 nm) is caused (most probably) by the presence in amniotic fluid of some hormones, NADH2 and NADPH2. A more long-wave component ((lambda) exc equals 460 nm; (lambda) em equals 520 - 560 nm) is most likely connected with the presence in amniotic fluid pigments (bilirubin connected with protein and other). It is shown that intensity and maximum of ultra-violet luminescence spectra of amniotic fluid in normality and at pathology are identical. However both emission spectra and excitation spectra of long-wave ((lambda) greater than 450 nm) luminescence of amniotic fluid from pregnant women with such prenatal abnormal developments of a fetus as anencephaly and spina bifida are too long-wave region in comparison with the norm. Results of research testify that spectral luminescent analysis of amniotic fluid can be used for screening of malformations of the neural tube. It is very difficult for a practical obstetrician to reveal pregnant women with a high risk of congenital malformations of the fetus. Apart from ultrasonic examination, cytogenetic examination of amniotic fluid and defumination of concentrations of alpha-fetoprotein and acetylcholin-esterases in the amniotic fluid and blood plasma are the most widely used diagnostic approaches. However, biochemical and cytogenetic diagnostic methods are time-consuming. In the present work spectral luminescence properties of the amniotic fluid are investigated to determine spectral parameters that can be used to reveal pregnant women with a high risk of congenital malformations of their offsprings.

Vortex locking in direct numerical simulations of quantum turbulence.

PubMed

Morris, Karla; Koplik, Joel; Rouson, Damian W I

2008-07-04

Direct numerical simulations are used to examine the locking of quantized superfluid vortices and normal fluid vorticity in evolving turbulent flows. The superfluid is driven by the normal fluid, which undergoes either a decaying Taylor-Green flow or a linearly forced homogeneous isotropic turbulent flow, although the back reaction of the superfluid on the normal fluid flow is omitted. Using correlation functions and wavelet transforms, we present numerical and visual evidence for vortex locking on length scales above the intervortex spacing.

Ultrasonic Fluid Quality Sensor System

DOEpatents

Gomm, Tyler J.; Kraft, Nancy C.; Phelps, Larry D.; Taylor, Steven C.

2003-10-21

A system for determining the composition of a multiple-component fluid and for determining linear flow comprising at least one sing-around circuit that determines the velocity of a signal in the multiple-component fluid and that is correlatable to a database for the multiple-component fluid. A system for determining flow uses two of the inventive circuits, one of which is set at an angle that is not perpendicular to the direction of flow.

Ultrasonic fluid quality sensor system

DOEpatents

Gomm, Tyler J.; Kraft, Nancy C.; Phelps, Larry D.; Taylor, Steven C.

2002-10-08

A system for determining the composition of a multiple-component fluid and for determining linear flow comprising at least one sing-around circuit that determines the velocity of a signal in the multiple-component fluid and that is correlatable to a database for the multiple-component fluid. A system for determining flow uses two of the inventive circuits, one of which is set at an angle that is not perpendicular to the direction of flow.

Low-frequency dispersion and attenuation in anisotropic partially saturated rocks

NASA Astrophysics Data System (ADS)

Cavallini, Fabio; Carcione, José M.; Vidal de Ventós, Daniel; Engell-Sørensen, Lisbeth

2017-06-01

The mesoscopic-loss mechanism is believed to be the most important attenuation mechanism in porous media at seismic frequencies. It is caused by P-wave conversion to slow diffusion (Biot) modes at material inhomogeneity on length scales of the order of centimetres. It is very effective in partially saturated media, particularly in the presence of gas. We explicitly extend the theory of wave propagation at normal incidence to three periodic thin layers and using this result we obtain the five complex and frequency-dependent stiffness components of the corresponding periodic finely layered medium, where the equivalent medium is anisotropic, specifically transversely isotropic. The relaxation behaviour can be described by a single complex and frequency-dependent stiffness component, since the medium consists of plane homogeneous layers. The media can be dissimilar in any property, but a relevant example in hydrocarbon exploration is the case of partial saturation and the same frame skeleton, where the fluid can be brine, oil and gas. The numerical examples illustrate the implementation of the theory to compute the wave velocities (phase and energy) and quality factors. We consider two main cases, namely, the same frame (or skeleton) and different fluids, and the same fluid and different frame properties. Unlike the two-phase case (two fluids), the results show two relaxation peaks. This scenario is more realistic since usually reservoirs rocks contain oil, brine and gas. The theory is quite general since it is not only restricted to partial saturation, but also applies to important properties such as porosity and permeability heterogeneities.

The Prediction of Students' Academic Performance With Fluid Intelligence in Giving Special Consideration to the Contribution of Learning.

PubMed

Ren, Xuezhu; Schweizer, Karl; Wang, Tengfei; Xu, Fen

2015-01-01

The present study provides a new account of how fluid intelligence influences academic performance. In this account a complex learning component of fluid intelligence tests is proposed to play a major role in predicting academic performance. A sample of 2, 277 secondary school students completed two reasoning tests that were assumed to represent fluid intelligence and standardized math and verbal tests assessing academic performance. The fluid intelligence data were decomposed into a learning component that was associated with the position effect of intelligence items and a constant component that was independent of the position effect. Results showed that the learning component contributed significantly more to the prediction of math and verbal performance than the constant component. The link from the learning component to math performance was especially strong. These results indicated that fluid intelligence, which has so far been considered as homogeneous, could be decomposed in such a way that the resulting components showed different properties and contributed differently to the prediction of academic performance. Furthermore, the results were in line with the expectation that learning was a predictor of performance in school.

The Prediction of Students’ Academic Performance With Fluid Intelligence in Giving Special Consideration to the Contribution of Learning

PubMed Central

Ren, Xuezhu; Schweizer, Karl; Wang, Tengfei; Xu, Fen

2015-01-01

The present study provides a new account of how fluid intelligence influences academic performance. In this account a complex learning component of fluid intelligence tests is proposed to play a major role in predicting academic performance. A sample of 2, 277 secondary school students completed two reasoning tests that were assumed to represent fluid intelligence and standardized math and verbal tests assessing academic performance. The fluid intelligence data were decomposed into a learning component that was associated with the position effect of intelligence items and a constant component that was independent of the position effect. Results showed that the learning component contributed significantly more to the prediction of math and verbal performance than the constant component. The link from the learning component to math performance was especially strong. These results indicated that fluid intelligence, which has so far been considered as homogeneous, could be decomposed in such a way that the resulting components showed different properties and contributed differently to the prediction of academic performance. Furthermore, the results were in line with the expectation that learning was a predictor of performance in school. PMID:26435760

Influence of Ophthalmic Solutions on Tear Components.

PubMed

Shigeyasu, Chika; Yamada, Masakazu; Akune, Yoko

2016-11-01

Tear fluids are a mixture of secretions derived from lacrimal glands, accessory lacrimal glands, conjunctiva, and meibomian glands. Compositional changes to tears occur in the normal state and during ocular surface disease, such as dry eye conditions. We have investigated compositional changes to tears after topical application of ophthalmic solutions, with regard to tear-specific proteins (secretory immunoglobulin A, lactoferrin, lipocalin-1, and lysozyme) and ocular surface mucin in normal and dry eye conditions using high-performance liquid chromatography. After application of saline solution (0.9% sodium chloride) in normal subjects, transient but significant decreases in all tear components were observed. The recovery of protein concentrations took up to 30 minutes and lasted longer when the saline solution was applied more frequently. When applying ophthalmic solutions, a balance between washout and dilutional effects should be considered in addition to the therapeutic effect. Investigation of the effect of diquafosol solution (3%) in normal subjects revealed a significant increase in sialic acid concentration, a marker of ocular mucin, at 5 minutes after application, whereas a significant decrease was observed with saline. This result indicates the accelerated secretion of mucin from ocular tissues induced by diquafosol. A clinical study to determine the efficacy of diquafosol in patients with dry eye revealed improvements in tear breakup time, keratoconjunctival staining scores, and Schirmer test score, accompanied by an increase in sialic acid concentration in tears. Investigating normal and dry eye conditions through tear analysis may clarify the pathophysiology of dry eye conditions and support the efficacy of treatments.

A New Approach for Very Large Broadband Geophysical Monitoring of rock Deformations Into Deep Boreholes: The "High-Pulse Poroelasticity Protocol" (HPPP)

NASA Astrophysics Data System (ADS)

Guglielmi, Y.; Cappa, F.; Virieux, J.; Rutqvist, J.; Tsang, C.

2007-12-01

We present a new approach, called the "High-Pulse Poroelasticity Protocol" (HPPP), for a very large broadband geophysical monitoring of rock deformations into deep boreholes (from 200 m to 1 km depth). The HPPP consists in developing an innovative probe that allows the hydromechanical loading of rocks with synchronous fluid pressure - 3D deformations (translational components along and in the orthogonal plan of the borehole axis, and rotational components along the longitudinal axis) - seismic wave measurements over a broadband of frequencies (from static to dynamic [1-1,000 Hz]). In this protocol, the rock is subjected to a controlled source corresponding to a fast (few seconds) hydraulic pressure pulse (pressure wave) localized into a short injection chamber (from 1 to 3 m) which is isolated between two inflatable packers in a borehole. In the chamber, measurements are done with fibre-optic and acoustic sensors that makes possible to use a wide range of frequencies (1-1,000 Hz) and high accuracy (10-7) sampling of fluid pressure and 3D deformations. When the pressure wave is applied, several poroelastic effects are measured: (i) a static poroelastic response that is linked to the fluid diffusion in phase with mechanical deformation of the porous rock; (ii) a low-frequency slow Biot wave (P2 wave) associated with the motion out of phase of solid and fluid phases; (iii) a high-frequency pressure wave that is generated and converted to seismic waves (P1 and S waves) at the borehole wall. This new approach aims at determining the infinitesimal shear and axial components of the strain tensor within the rock crossed by a borehole. The HPPP also allows studying the relationships between elastic waves propagation and rock hydromechanical properties and state at an intermediate scale (mesoscopic scale), between the laboratory and crustal scales, in a volume of one to a few tens of meters around the borehole. This new approach was designed from previous pulse testing done in a fault zone with a first prototype of the HPPP probe capable of simultaneously measuring changes (with a high frequency [120 Hz] and high accuracy) in fluid pressure (± 1 kPa) and displacement normal to the fault (± 10-7 m). This prototype consisted of a fibre-optic fluid pressure and a fibre-optic normal displacement sensor fixed to the borehole walls by two anchors located on both sides of the fault which was isolated with two packers to create a 0.4 m injection chamber. Results indicated that fiber-optic measurements allow good capturing of all the high-frequency changes during the hydraulic pulse. The method appears useful for accurately measuring time discrepancies between pressure and deformation signals as small as a few milliseconds. Moreover, high-frequency measurement of the fault "pressure-deformation" poroelastic response allows highlighting of a loop-shaped evolution that is not observed in conventional laboratory or in situ experiments. Consequently, the HPPP approach will provide new data with axial and shear components of the strain tensor which will give us additional information for determination of the rock seismic and hydromechanical properties at various depths in the crust. Moreover, the HPPP will be adapted to study seismic and mechanical instability of fault zones under controlled hydraulic loading and localized in a point source.

Glutathione levels in plasma, saliva and gingival crevicular fluid after periodontal therapy in obese and normal weight individuals.

PubMed

Öngöz Dede, F; Bozkurt Doğan, Ş; Balli, U; Avci, B; Durmuşlar, M C; Baratzade, T

2016-12-01

The purpose of this study was to investigate the effects of obesity on reduced and oxidized glutathione (GSH and GSSG) levels in the gingival crevicular fluid, plasma and saliva of patients with chronic periodontitis and to evaluate the changes after nonsurgical periodontal therapy. The study included 60 patients: 30 patients with chronic periodontitis (15 obese patients and 15 normal weight patients) and 30 healthy control subjects (15 obese patients and 15 normal weight patients). Gingival crevicular fluid, plasma and saliva samples were collected, and clinical periodontal measurements were recorded at baseline and at the first month after periodontal therapy from patients with chronic periodontitis. GSH and GSSG levels were analyzed with spectrophotometry. The GSH levels in the plasma, saliva and gingival crevicular fluid in obese individuals with chronic periodontitis were lower than in normal weight individuals at baseline (p < 0.01). There was a significant difference in the GSH/GSSG ratio in plasma and gingival crevicular fluid between the obese and normal weight groups at baseline (p < 0.01). The GSH levels in plasma, gingival crevicular fluid and saliva were significantly increased in both chronic periodontitis groups after nonsurgical periodontal therapy (p < 0.01). A significant positive correlation was found between GSH levels in saliva, plasma and gingival crevicular fluid in all groups (p < 0.001). The study revealed that obesity in patients with chronic periodontitis is associated with decreased GSH levels and the GSH/GSSG ratio. Moreover, nonsurgical periodontal therapy may be helpful for improvement in glutathione values in obese and normal weight individuals with chronic periodontitis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Effect of Volume of Fluid Resuscitation on Metabolic Normalization in Children Presenting in Diabetic Ketoacidosis: A Randomized Controlled Trial.

PubMed

Bakes, Katherine; Haukoos, Jason S; Deakyne, Sara J; Hopkins, Emily; Easter, Josh; McFann, Kim; Brent, Alison; Rewers, Arleta

2016-04-01

The optimal rate of fluid administration in pediatric diabetic ketoacidosis (DKA) is unknown. Our aim was to determine whether the volume of fluid administration in children with DKA influences the rate of metabolic normalization. We performed a randomized controlled trial conducted in a tertiary pediatric emergency department from December 2007 until June 2010. The primary outcome was time to metabolic normalization; secondary outcomes were time to bicarbonate normalization, pH normalization, overall length of hospital treatment, and adverse outcomes. Children between 0 and 18 years of age were eligible if they had type 1 diabetes mellitus and DKA. Patients were randomized to receive intravenous (IV) fluid at low volume (10 mL/kg bolus + 1.25 × maintenance rate) or high volume (20 mL/kg bolus + 1.5 × maintenance rate) (n = 25 in each). After adjusting for initial differences in bicarbonate levels, time to metabolic normalization was significantly faster in the higher-volume infusion group compared to the low-volume infusion group (hazard ratio [HR] = 2.0; 95% confidence interval [CI] 1.0-3.9; p = 0.04). Higher-volume IV fluid infusion appeared to hasten, to a greater extent, normalization of pH (HR = 2.5; 95% CI 1.2-5.0; p = 0.01) than normalization of serum bicarbonate (HR = 1.2; 95% CI 0.6-2.3; p = 0.6). The length of hospital treatment HR (0.8; 95% CI 0.4-1.5; p = 0.5) and time to discharge HR (0.8; 95% CI 0.4-1.5; p = 0.5) did not differ between treatment groups. Higher-volume fluid infusion in the treatment of pediatric DKA patients significantly shortened metabolic normalization time, but did not change overall length of hospital treatment. ClinicalTrials.gov ID NCT01701557. Copyright © 2016 Elsevier Inc. All rights reserved.

Calibration method and apparatus for measuring the concentration of components in a fluid

DOEpatents

Durham, M.D.; Sagan, F.J.; Burkhardt, M.R.

1993-12-21

A calibration method and apparatus for use in measuring the concentrations of components of a fluid is provided. The measurements are determined from the intensity of radiation over a selected range of radiation wavelengths using peak-to-trough calculations. The peak-to-trough calculations are simplified by compensating for radiation absorption by the apparatus. The invention also allows absorption characteristics of an interfering fluid component to be accurately determined and negated thereby facilitating analysis of the fluid. 7 figures.

Calibration method and apparatus for measuring the concentration of components in a fluid

DOEpatents

Durham, Michael D.; Sagan, Francis J.; Burkhardt, Mark R.

1993-01-01

A calibration method and apparatus for use in measuring the concentrations of components of a fluid is provided. The measurements are determined from the intensity of radiation over a selected range of radiation wavelengths using peak-to-trough calculations. The peak-to-trough calculations are simplified by compensating for radiation absorption by the apparatus. The invention also allows absorption characteristics of an interfering fluid component to be accurately determined and negated thereby facilitating analysis of the fluid.

Paleozoic fluid history of the Michigan Basin: Evidence from dolomite geochemistry in the Middle Ordovician St. Peter Sandstone

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winter, B.L.; Johnson, C.M.; Simo, J.A.

1995-04-03

The isotope (Sr and O) and elemental (Mg, Ca, Mn, Fe, and Sr) compositions of the various dolomites in the Middle Ordovician St. Peter Sandstone in the Michigan Basin are determined and the variations are modeled in terms of fluid-rock interaction or as mixing relations. These geochemical models, combined with the paragenetic sequence of the dolomites and late anhydrite cement, suggest the existence of at least four distinct diagenetic fluids in the St. Peter Sandstone during the paleozoic. Fluid 1 has a composition consistent with a modified older (pre-Middle Ordovician) seawater origin, which indicates that the flow path for thismore » fluid had a major upward component. This fluid resulted in the first and volumetrically most important burial dolomitization event, producing dolomite in both carbonate and quartz sandstone lithofacies in the St. Peter Sandstone. Fluid 2 has a composition consistent with a modified Middle to early Late Ordovician seawater origin, suggesting a major downward component for fluid flow. Fluid 2 produced dolomite cement in the carbonate lithofacies that postdates Fluid 1 dolomite. The composition of Fluid 3 is best interpreted to reflect a heated, deep basinal brine that had previously interacted with the K-feldspar-rich rocks near the Cambrian-Precambrian unconformity in the Michigan Basin, indicating a major upward component for fluid flow. Fluid 3 produced dolomite cement in quartz sandstone lithofacies that postdates Fluid 1 dolomite. Fluid 4 resulted in precipitation of late anhydrite in fractures. The {sup 87}Sr/{sup 86}Sr ratio of the anhydrite is consistent with Fluid 4 originating as a dilute fluid that interacted extensively with Silurian gypsum in the Michigan Basin; this indicates that the flow path of Fluid 4 had a major downward component.« less

Canine adipose-derived stromal cell viability following exposure to synovial fluid from osteoarthritic joints.

PubMed

Kiefer, Kristina M; O'Brien, Timothy D; Pluhar, Elizabeth G; Conzemius, Michael

2015-01-01

Stem cell therapy used in clinical application of osteoarthritis in veterinary medicine typically involves intra-articular injection of the cells, however the effect of an osteoarthritic environment on the fate of the cells has not been investigated. Assess the viability of adipose derived stromal cells following exposure to osteoarthritic joint fluid. Adipose derived stromal cells (ASCs) were derived from falciform adipose tissue of five adult dogs, and osteoarthritic synovial fluid (SF) was obtained from ten patients undergoing surgical intervention on orthopedic diseases with secondary osteoarthritis. Normal synovial fluid was obtained from seven adult dogs from an unrelated study. ASCs were exposed to the following treatment conditions: culture medium, normal SF, osteoarthritic SF, or serial dilutions of 1:1 to 1:10 of osteoarthritic SF with media. Cells were then harvested and assessed for viability using trypan blue dye exclusion. There was no significant difference in the viability of cells in culture medium or normal SF. Significant differences were found between cells exposed to any concentration of osteoarthritic SF and normal SF and between cells exposed to undiluted osteoarthritic SF and all serial dilutions. Subsequent dilutions reduced cytotoxicity. Osteoarthritic synovial fluid in this ex vivo experiment is cytotoxic to ASCs, when compared with normal synovial fluid. Current practice of direct injection of ASCs into osteoarthritic joints should be re-evaluated to determine if alternative means of administration may be more effective.

Two part condenser for varying the rate of condensing and related method

DOEpatents

Dobos, James G.

2007-12-11

A heat transfer apparatus, such as a condenser, is provided. The apparatus includes a first component with a first heat transfer element that has first component inlet and outlet ports through which a first fluid may pass. A second component is also included and likewise has a second heat transfer element with second component inlet and outlet ports to pass a second fluid. The first component has a body that can receive a third fluid for heat transfer with the first heat transfer element. The first and second components are releasably attachable with one another so that when attached both the first and second heat transfer elements effect heat transfer with the third fluid. Attachment and removal of the first and second components allows for the heat transfer rate of the apparatus to be varied. An associated method is also provided.

Modelling the normal bouncing dynamics of spheres in a viscous fluid

NASA Astrophysics Data System (ADS)

Izard, Edouard; Lacaze, Laurent; Bonometti, Thomas

2017-06-01

Bouncing motions of spheres in a viscous fluid are numerically investigated by an immersed boundary method to resolve the fluid flow around solids which is combined to a discrete element method for the particles motion and contact resolution. Two well-known configurations of bouncing are considered: the normal bouncing of a sphere on a wall in a viscous fluid and a normal particle-particle bouncing in a fluid. Previous experiments have shown the effective restitution coefficient to be a function of a single parameter, namely the Stokes number which compares the inertia of the solid particle with the fluid viscous dissipation. The present simulations show a good agreement with experimental observations for the whole range of investigated parameters. However, a new definition of the coefficient of restitution presented here shows a dependence on the Stokes number as in previous works but, in addition, on the fluid to particle density ratio. It allows to identify the viscous, inertial and dry regimes as found in experiments of immersed granular avalanches of Courrech du Pont et al. Phys. Rev. Lett. 90, 044301 (2003), e.g. in a multi-particle configuration.

Solvability and Regularity for an Elliptic System Prescribing the Curl, Divergence, and Partial Trace of a Vector Field on Sobolev-Class Domains

NASA Astrophysics Data System (ADS)

Cheng, C. H. Arthur; Shkoller, Steve

2017-09-01

We provide a self-contained proof of the solvability and regularity of a Hodge-type elliptic system, wherein the divergence and curl of a vector field u are prescribed in an open, bounded, Sobolev-class domain {Ω \\subseteq R^n}, and either the normal component {{u} \\cdot {N}} or the tangential components of the vector field {{u} × {N}} are prescribed on the boundary {partial Ω}. For {k > n/2}, we prove that u is in the Sobolev space {H^k+1(Ω)} if {Ω} is an {H^k+1}-domain, and the divergence, curl, and either the normal or tangential trace of u has sufficient regularity. The proof is based on a regularity theory for vector elliptic equations set on Sobolev-class domains and with Sobolev-class coefficients, and with a rather general set of Dirichlet and Neumann boundary conditions. The resulting regularity theory for the vector u is fundamental in the analysis of free-boundary and moving interface problems in fluid dynamics.

Numerical schemes for anomalous diffusion of single-phase fluids in porous media

NASA Astrophysics Data System (ADS)

Awotunde, Abeeb A.; Ghanam, Ryad A.; Al-Homidan, Suliman S.; Tatar, Nasser-eddine

2016-10-01

Simulation of fluid flow in porous media is an indispensable part of oil and gas reservoir management. Accurate prediction of reservoir performance and profitability of investment rely on our ability to model the flow behavior of reservoir fluids. Over the years, numerical reservoir simulation models have been based mainly on solutions to the normal diffusion of fluids in the porous reservoir. Recently, however, it has been documented that fluid flow in porous media does not always follow strictly the normal diffusion process. Small deviations from normal diffusion, called anomalous diffusion, have been reported in some experimental studies. Such deviations can be caused by different factors such as the viscous state of the fluid, the fractal nature of the porous media and the pressure pulse in the system. In this work, we present explicit and implicit numerical solutions to the anomalous diffusion of single-phase fluids in heterogeneous reservoirs. An analytical solution is used to validate the numerical solution to the simple homogeneous case. The conventional wellbore flow model is modified to account for anomalous behavior. Example applications are used to show the behavior of wellbore and wellblock pressures during the single-phase anomalous flow of fluids in the reservoirs considered.

Surface thermodynamics, surface stress, equations at surfaces and triple lines for deformable bodies.

PubMed

Olives, Juan

2010-03-03

The thermodynamics and mechanics of the surface of a deformable body are studied here, following and refining the general approach of Gibbs. It is first shown that the 'local' thermodynamic variables of the state of the surface are only the temperature, the chemical potentials and the surface strain tensor (true thermodynamic variables, for a viscoelastic solid or a viscous fluid). A new definition of the surface stress is given and the corresponding surface thermodynamics equations are presented. The mechanical equilibrium equation at the surface is then obtained. It involves the surface stress and is similar to the Cauchy equation for the volume. Its normal component is a generalization of the Laplace equation. At a (body-fluid-fluid) triple contact line, two equations are obtained, which represent: (i) the equilibrium of the forces (surface stresses) for a triple line fixed on the body; (ii) the equilibrium relative to the motion of the line with respect to the body. This last equation leads to a strong modification of Young's classical capillary equation.

Development of an integrated BEM approach for hot fluid structure interaction

NASA Technical Reports Server (NTRS)

Dargush, G. F.; Banerjee, P. K.; Shi, Y.

1990-01-01

A comprehensive boundary element method is presented for transient thermoelastic analysis of hot section Earth-to-Orbit engine components. This time-domain formulation requires discretization of only the surface of the component, and thus provides an attractive alternative to finite element analysis for this class of problems. In addition, steep thermal gradients, which often occur near the surface, can be captured more readily since with a boundary element approach there are no shape functions to constrain the solution in the direction normal to the surface. For example, the circular disc analysis indicates the high level of accuracy that can be obtained. In fact, on the basis of reduced modeling effort and improved accuracy, it appears that the present boundary element method should be the preferred approach for general problems of transient thermoelasticity.

Selective chemical detection by energy modulation of sensors

DOEpatents

Stetter, J.R.; Otagawa, T.

1991-09-10

A portable instrument for use in the field in detecting, identifying, and quantifying a component of a sampled fluid includes a sensor which chemically reacts with the component of interest or a derivative thereof, an electrical heating filament for heating the sample before it is applied to the sensor, and modulator for continuously varying the temperature of the filament (and hence the reaction rate) between two values sufficient to produce the chemical reaction. In response to this thermal modulation, the sensor produces a modulated output signal, the modulation of which is a function of the activation energy of the chemical reaction, which activation energy is specific to the particular component of interest and its concentration. Microprocessor which compares the modulated output signal with standard responses for a plurality of components to identify and quantify the particular component of interest. In particular, the concentration of the component of interest is proportional to the amplitude of the modulated output signal, while the identifying activation output energy of the chemical interaction indicative of that component is proportional to a normalized parameter equal to the peak-to-peak amplitude divided by the height of the upper peaks above a base line signal level. 5 figures.

Selective chemical detection by energy modulation of sensors

DOEpatents

Stetter, Joseph R.; Otagawa, Takaaki

1991-01-01

A portable instrument for use in the field in detecting, identifying, and quantifying a component of a sampled fluid includes a sensor which chemically reacts with the component of interest or a derivative thereof, an electrical heating filament for heating the sample before it is applied to the sensor, and modulator for continuously varying the temperature of the filament (and hence the reaction rate) between two values sufficient to produce the chemical reaction. In response to this thermal modulation, the sensor produces a modulated output signal, the modulation of which is a function of the activation energy of the chemical reaction, which activation energy is specific to the particular component of interest and its concentration. Microprocessor which compares the modulated output signal with standard responses for a plurality of components to identify and quantify the particular component of interest. In particular, the concentration of the component of interest is proportional to the amplitude of the modulated output signal, while the identifying activation output energy of the chemical interaction indicative of that component is proportional to a normalized parameter equal to the peak-to-peak amplitude divided by the height of the upper peaks above a base line signal level.

Centrifugal adsorption system

NASA Technical Reports Server (NTRS)

Gonda, Steve R. (Inventor); Tsao, Yow-Min D. (Inventor); Lee, Wenshan (Inventor)

2006-01-01

A gas-liquid separator uses a helical passageway to impart a spiral motion to a fluid passing therethrough. The centrifugal force generated by the spiraling motion urges the liquid component of the fluid radially outward which forces the gas component radially inward. The gas component is then separated through a gas-permeable, liquid-impervious membrane and discharged through a central passageway. A filter material captures target substances contained in the fluid.

Feasibility of correlating separation of ternary mixtures of neutral analytes via thin layer chromatography with supercritical fluid chromatography in support of green flash separations.

PubMed

Ashraf-Khorassani, M; Yan, Q; Akin, A; Riley, F; Aurigemma, C; Taylor, L T

2015-10-30

Method development for normal phase flash liquid chromatography traditionally employs preliminary screening using thin layer chromatography (TLC) with conventional solvents on bare silica. Extension to green flash chromatography via correlation of TLC migration results, with conventional polar/nonpolar liquid mixtures, and packed column supercritical fluid chromatography (SFC) retention times, via gradient elution on bare silica with a suite of carbon dioxide mobile phase modifiers, is reported. Feasibility of TLC/SFC correlation is individually described for eight ternary mixtures for a total of 24 neutral analytes. The experimental criteria for TLC/SFC correlation was assumed to be as follows: SFC/UV/MS retention (tR) increases among each of the three resolved mixture components; while, TLC migration (Rf) decreases among the same resolved mixture components. Successful correlation of TLC to SFC was observed for most of the polar organic solvents tested, with the best results observed via SFC on bare silica with methanol as the CO2 modifier and TLC on bare silica with a methanol/dichloromethane mixture. Copyright © 2015 Elsevier B.V. All rights reserved.

Predicting the onset of high-frequency self-excited oscillations in a channel with an elastic wall

NASA Astrophysics Data System (ADS)

Ward, Thomas; Whittaker, Robert

2016-11-01

Flow-induced oscillations of fluid-conveying elastic-walled channels arise in many industrial and biological systems including the oscillation of the vocal cords during phonation. We derive a system of equations that describes the wall displacement in response to the steady and oscillatory components of the fluid pressure derived by Whittaker et al. (2010). We show that the steady pressure component results in a base state deformation assumed to be small in magnitude relative to the length of the channel. The oscillation frequency of the elastic wall is determined by an eigenvalue problem paramterised by the shape of the base state deformation, the strength of axial tension relative to azimuthal bending, F , and the size of non-linear stretching effects from the wall's initial deformation, K . We determine the slow growth or decay of the normal modes in each by considering the energy budget of the system. The amplitude of the oscillations grow or decay exponentially with a growth rate Λ, which may be expressed in terms of a critical Reynolds number Rec . We use numerical simulations to identify three distinct regions in parameter regimes space and determine the stability of oscillations in each.

Second-sound studies of coflow and counterflow of superfluid {sup 4}He in channels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Varga, Emil; Skrbek, L.; Babuin, Simone, E-mail: babuin@fzu.cz

2015-06-15

We report a comprehensive study of turbulent superfluid {sup 4}He flow through a channel of square cross section. We study for the first time two distinct flow configurations with the same apparatus: coflow (normal and superfluid components move in the same direction), and counterflow (normal and superfluid components move in opposite directions). We realise also a variation of counterflow with the same relative velocity, but where the superfluid component moves while there is no net flow of the normal component through the channel, i.e., pure superflow. We use the second-sound attenuation technique to measure the density of quantised vortex linesmore » in the temperature range 1.2 K ≲ T ≲ T{sub λ} ≈ 2.18 K and for flow velocities from about 1 mm/s up to almost 1 m/s in fully developed turbulence. We find that both the steady-state and temporal decay of the turbulence significantly differ in the three flow configurations, yielding an interesting insight into two-fluid hydrodynamics. In both pure superflow and counterflow, the same scaling of vortex line density with counterflow velocity is observed, L∝V{sub cf}{sup 2}, with a pronounced temperature dependence; in coflow instead, the vortex line density scales with velocity as L ∝ V{sup 3/2} and is temperature independent; we provide theoretical explanations for these observations. Further, we develop a new promising technique to use different second-sound resonant modes to probe the spatial distribution of quantised vortices in the direction perpendicular to the flow. Preliminary measurements indicate that coflow is less homogeneous than counterflow/superflow, with a denser concentration of vortices between the centre of the channel and its walls.« less

Characterisation of lubricin in synovial fluid from horses with osteoarthritis.

PubMed

Svala, E; Jin, C; Rüetschi, U; Ekman, S; Lindahl, A; Karlsson, N G; Skiöldebrand, E

2017-01-01

The glycoprotein lubricin contributes to the boundary lubrication of the articular cartilage surface. The early events of osteoarthritis involve the superficial layer where lubricin is synthesised. To characterise the glycosylation profile of lubricin in synovial fluid from horses with osteoarthritis and study secretion and degradation of lubricin in an in vitro inflammation cartilage model. In vitro study. Synovial fluid samples collected from horses with joints with normal articular cartilage and structural osteoarthritic lesions; with and without osteochondral fragments, were analysed for the lubricin glycosylation profiles. Articular cartilage explants were stimulated with or without interleukin-1β for 25 days. Media samples collected at 3-day intervals were analysed by quantitative proteomics, western blot and enzyme-linked immunosorbent assay. O-glycosylation profiles in synovial fluid revealed both Core 1 and 2 O-glycans, with Core 1 O-glycans predominating. Synovial fluid from normal joints (49.5 ± 1.9%) contained significantly lower amounts of monosialylated Core 1 O-glycans compared with joints with osteoarthritis (53.8 ± 7.8%, P = 0.03) or joints with osteochondral fragments (57.3 ± 8.8%, P = 0.001). Additionally, synovial fluid from normal joints (26.7 ± 6.7%) showed higher amounts of disialylated Core 1 O-glycan than from joints with osteochondral fragments (21.2 ± 4.9%, P = 0.03). A C-terminal proteolytic cleavage site in lubricin was found in synovial fluid from normal and osteochondral fragment joints and in media from interleukin-1β stimulated and unstimulated articular cartilage explants. This is the first demonstration of a change in the glycosylation profile of lubricin in synovial fluid from diseased equine joints compared with that from normal joints. We demonstrate an identical proteolytic cleavage site of lubricin both in vitro and in vivo. The reduced sialation of lubricin in synovial fluid from diseased joints may affect the boundary lubricating ability of the superficial layer of articular cartilage and could be one of the early events in the progression of osteoarthritis. © 2015 EVJ Ltd.

Continuous Data Assimilation for a 2D Bénard Convection System Through Horizontal Velocity Measurements Alone

NASA Astrophysics Data System (ADS)

Farhat, Aseel; Lunasin, Evelyn; Titi, Edriss S.

2017-06-01

In this paper we propose a continuous data assimilation (downscaling) algorithm for a two-dimensional Bénard convection problem. Specifically we consider the two-dimensional Boussinesq system of a layer of incompressible fluid between two solid horizontal walls, with no-normal flow and stress-free boundary conditions on the walls, and the fluid is heated from the bottom and cooled from the top. In this algorithm, we incorporate the observables as a feedback (nudging) term in the evolution equation of the horizontal velocity. We show that under an appropriate choice of the nudging parameter and the size of the spatial coarse mesh observables, and under the assumption that the observed data are error free, the solution of the proposed algorithm converges at an exponential rate, asymptotically in time, to the unique exact unknown reference solution of the original system, associated with the observed data on the horizontal component of the velocity.

A small-volume PVTX system for broadband spectroscopic calibration of downhole optical sensors

NASA Astrophysics Data System (ADS)

Jones, Christopher Michael; Pelletier, Michael T.; Atkinson, Robert; Shen, Jing; Moore, Jeff; Anders, Jimmy; Perkins, David L.; Myrick, Michael L.

2017-07-01

An instrument is presented that is capable of measuring the optical spectrum (long-wave ultraviolet through short-wave mid-infrared) of fluids under a range of temperature and pressure conditions from ambient pressure up to 138 MPa (20 000 psi) and 422 K (300 °F) using ˜5 ml of fluid. Temperature, pressure, and density are measured in situ in real-time, and composition is varied by adding volatile and nonvolatile components. The stability and accuracy of the conditions are reported for pure ethane, and the effects of temperature and pressure on characteristic regions of the optical spectrum of ethane are illustrated after correction for temperature and pressure effects on the optical cell path length, as well as normalization to the measured density. Molar absorption coefficients and integrated molar absorption coefficients for several vibrational combination bands are presented.

Space and time distribution of foci and source-mechanisms of West-Bohemia/Vogtland earthquake swarms - a tool for insight into their triggering mechanisms and driving forces

NASA Astrophysics Data System (ADS)

Horalek, Josef; Fischer, Tomas; Cermakova, Hana

2013-04-01

West Bohemia/Vogtland (border area between Czech Republic and Germany) belongs to the most active intraplate earthquake-swarm regions in Europe. Above, this area is characteristic by high activity of crustal fluids. Swarm earthquakes with magnitudes ML < 4.0 occur frequently in the area of about 3 000 km2, however, the Nový Kostel focal zone (NK), which shows a few tens of thousands events within the last twenty years, dominates the recent seismicity of the whole region. During last fifteen years there were four earthquake swarms in 1997, 2000, 2008 and 20011 (besides a few tens of microswarms) encompassing a fault plane of about 15 x 6 km. The swarms were located close to each other. Moreover, the 2000 (MLmax = 3.3) and 2008 (MLmax = 3.8) swarms were "twins", i.e. their hypocenters fall precisely on the same portion of the NK fault plane; and the 1997 (MLmax = 2.9) and 2011 (MLmax = 3.6) swarms also occurred on the same fault segment. However, the individual swarms differed considerably in their evolution, mainly in the rate of the seismic-moment release and foci migration. Source mechanisms (in the full moment-tensor description) and their time and space variations also show different patterns. All the 2000- and 2008-swarm events were pure shears, most of them showing the oblique normal faulting. Although source mechanisms of majority of the 2000- and 2008 events signify the faulting parallel to the main NK fault plane, there is a significant amount of events having different source mechanisms. We also found alteration of the source mechanisms with depths. The 1997 and 2011 swarms took place on two differently oriented fault segments thus two different source mechanisms occurred: the oblique-normal on the one segment and the oblique-thrust type on the other one. Moreover, source mechanisms of the oblique thrust events suggest combined sources (possessing significant non-DC components). This indicates complexity of both NK focal zone (where earthquake swarms have periodically occurred) and rupturing in the individual swarms. Similar pattern of the strain energy release we disclosed for seismicity due to fluid injection into deep boreholes at HDR site Soultz-sous-Forêts (France) in 2003. We analyzed the spatial and temporal distribution of micro-earthquakes and their source mechanisms and found that injected fluids triggered large seismicity (pure-shear events) at two existing natural fault segments, which ran independently of the injection strategy. Taking into account all our results, we can conclude that earthquake swarms occur on short subcritically loaded fault segments which are affected by crustal fluids. Pressurized fluids reduced normal component of the tectonic stress and lower friction, thus decrease the shear strength of the medium (in terms of Coulomb friction criterion). On critically loaded and favourably oriented fault segments the swarm activity is driven by the differential local stress, the shear rupturing occurs.

A simulation for teaching the basic and clinical science of fluid therapy.

PubMed

Rawson, Richard E; Dispensa, Marilyn E; Goldstein, Richard E; Nicholson, Kimberley W; Vidal, Noni Korf

2009-09-01

The course "Management of Fluid and Electrolyte Disorders" is an applied physiology course taught using lectures and paper-based cases. The course approaches fluid therapy from both basic science and clinical perspectives. While paper cases provide a basis for application of basic science concepts, they lack key components of genuine clinical cases that, by nature, are diverse, change over time, and respond in unique ways to therapeutic interventions. We developed a dynamic model using STELLA software that simulates normal and abnormal fluid and electrolyte balance in the dog. Students interact, not with the underlying model, but with a user interface that provides sufficient data (skin turgor, chemistry panel, etc.) for the clinical assessment of patients and an opportunity for treatment. Students administer fluids and supplements, and the model responds in "real time," requiring regular reassessment and, potentially, adaptation of the treatment strategy. The level of success is determined by clinical outcome, including improvement, deterioration, or death. We expected that the simulated cases could be used to teach both the clinical and basic science of fluid therapy. The simulation provides exposure to a realistic clinical environment, and students tend to focus on this aspect of the simulation while, for the most part, ignoring an exploration of the underlying physiological basis for patient responses. We discuss how the instructor's expertise can provide sufficient support, feedback, and scaffolding so that students can extract maximum understanding of the basic science in the context of assessing and treating at the clinical level.

A novel method for a fast diagnosis of septic arthritis using mid infrared and deported spectroscopy.

PubMed

Albert, Jean-David; Monbet, Valérie; Jolivet-Gougeon, Anne; Fatih, Nadia; Le Corvec, Maëna; Seck, Malik; Charpentier, Frédéric; Coiffier, Guillaume; Boussard-Pledel, Catherine; Bureau, Bruno; Guggenbuhl, Pascal; Loréal, Olivier

2016-05-01

To assess the ability of mid infrared deported spectroscopy to discriminate synovial fluids samples of septic arthritis patients from other causes of joint effusion. Synovial fluids obtained from patients with clinically suspected arthritis were collected, analysed and classified according to standard diagnostic procedures as septic or non-septic. A spectroscopic analysis on synovial fluid samples was then performed using a coiled optical fiber made with chalcogenide glass. After a factorial analysis of the normalized spectra and the computation of a Fisher test used to select the most relevant components, a logistic regression model was fitted, allowing to attribute a score between 0 - non-septic -, and 1 - septic. In a first phase, we analysed the synovial fluids from 122 different synovial fluids including 6 septic arthritis among arthritis of various origins. Septic synovial fluids were identified with a sensitivity of 95.8% and a specificity of 93.9% and an AUROC of 0.977. The analysis of an independent set of samples (n=42, including two septic arthritis) gave similar values. Our data strongly supports the interest of mid infrared deported spectroscopy, which could be used potentially at point of care, for a rapid and easy diagnosis of septic arthritis. Now, the precision of the diagnosis must be evaluated through a multicentric study on a larger panel of patients. Copyright © 2015 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.

Method to separate lignin-rich solid phase from acidic biomass suspension at an acidic pH

DOEpatents

Yasarla, Kumar Lakshmi Rakesh; Ramarao, Bandaru V; Amidon, Thomas

2017-09-05

A method of separating a lignin-rich solid phase from a solution suspension, by pretreating a lignocellulosic biomass with a pretreatment fluid having remove soluble components, colloidal material and primarily lignin containing particles; separating the pretreated lignocellulosic biomass from the pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles; flocculating the separated pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles using polyethylene oxide (i.e., PEO) or cationic Poly acrylamide (i.e., CPAM) as a flocculating agent; and filtering the flocculated separated pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles to remove agglomerates.

Renal function alterations during skeletal muscle disuse in simulated microgravity

NASA Technical Reports Server (NTRS)

Tucker, Bryan J.

1992-01-01

This project was to examine the alterations in renal functions during skeletal muscle disuse in simulated microgravity. Although this area could cover a wide range of investigative efforts, the limited funding resulted in the selection of two projects. These projects would result in data contributing to an area of research deemed high priority by NASA and would address issues of the alterations in renal response to vasoactive stimuli during conditions of skeletal muscle disuse as well as investigate the contribution of skeletal muscle disuse, conditions normally found in long term human exposure to microgravity, to the balance of fluid and macromolecules within the vasculature versus the interstitium. These two projects selected are as follows: investigate the role of angiotensin 2 on renal function during periods of simulated microgravity and skeletal muscle disuse to determine if the renal response is altered to changes in circulating concentrations of angiotensin 2 compared to appropriate controls; and determine if the shift of fluid balance from vasculature to the interstitium, the two components of extracellular fluid volume, that occur during prolonged exposure to microgravity and skeletal muscle disuse is a result, in part, to alterations in the fluid and macromolecular balance in the peripheral capillary beds, of which the skeletal muscle contains the majority of recruitment capillaries. A recruitment capillary bed would be most sensitive to alterations in Starling forces and fluid and macromolecular permeability.

Cytological analysis of bronchoalveolar lavage fluid acquired by bronchoscopy in healthy ferrets: A pilot study

PubMed Central

Bercier, Marjorie; Langlois, Isabelle; Dunn, Marilyn; Hélie, Pierre; Burns, Patrick; Gara-Boivin, Carolyn

2016-01-01

The objective of this study was to investigate the normal cytological evaluation of bronchoalveolar lavage (BAL) fluid in healthy adult ferrets (N = 12). These ferrets underwent bronchoscopy and BAL using sterile saline [1.5 mL/kg body weight (BW)]. Percentage of fluid recovered, total leukocyte count, differential leukocyte count, and cell count of the epithelial lining fluid (ELF) were determined. The mean percentage of lavage volume recovered from the right lung and left lung were 67.8 ± 14.9% and 69.7 ± 20.0%, respectively. Gender (P = 0.12) and weight (P = 0.17) did not significantly affect the mean percentage of recovered volume. The mean percentage of recovered volume (P = 0.47) and the mean leukocyte count (P = 0.17) from the right and left lung were not significantly different. Macrophages were the main leukocyte component of the lavages, followed by neutrophils, lymphocytes, and eosinophils. The mean proportion of ELF in BAL fluid was 9.3 ± 3.7% v/v. Bronchoscopy is clinically useful for collecting good quality BAL samples for cytological analysis in ferrets. The leucocyte differential was established, which may help veterinarians to make better clinical decisions when treating respiratory disease. Further studies are required with a larger group in order to establish the healthy reference intervals for BAL values in ferrets. PMID:26733735

Cytological analysis of bronchoalveolar lavage fluid acquired by bronchoscopy in healthy ferrets: A pilot study.

PubMed

Bercier, Marjorie; Langlois, Isabelle; Dunn, Marilyn; Hélie, Pierre; Burns, Patrick; Gara-Boivin, Carolyn

2016-01-01

The objective of this study was to investigate the normal cytological evaluation of bronchoalveolar lavage (BAL) fluid in healthy adult ferrets (N = 12). These ferrets underwent bronchoscopy and BAL using sterile saline [1.5 mL/kg body weight (BW)]. Percentage of fluid recovered, total leukocyte count, differential leukocyte count, and cell count of the epithelial lining fluid (ELF) were determined. The mean percentage of lavage volume recovered from the right lung and left lung were 67.8 ± 14.9% and 69.7 ± 20.0%, respectively. Gender (P = 0.12) and weight (P = 0.17) did not significantly affect the mean percentage of recovered volume. The mean percentage of recovered volume (P = 0.47) and the mean leukocyte count (P = 0.17) from the right and left lung were not significantly different. Macrophages were the main leukocyte component of the lavages, followed by neutrophils, lymphocytes, and eosinophils. The mean proportion of ELF in BAL fluid was 9.3 ± 3.7% v/v. Bronchoscopy is clinically useful for collecting good quality BAL samples for cytological analysis in ferrets. The leucocyte differential was established, which may help veterinarians to make better clinical decisions when treating respiratory disease. Further studies are required with a larger group in order to establish the healthy reference intervals for BAL values in ferrets.

On the determination of the dynamic properties of a transformer oil based ferrofluid in the frequency range 0.1-20 GHz

NASA Astrophysics Data System (ADS)

Fannin, P. C.; Vekas, L.; Marin, C. N.; Malaescu, I.

2017-02-01

Complex susceptibility measurements provide a unique and efficient means for the investigation and determination of the dynamic properties of magnetic fluids. In particular, measurement of the frequency, f(Hz), and field, H(kA/m), dependent, complex susceptibility, χ(ω, Η)= χ‧(ω, Η)-iχ″(ω, Η), of magnetic fluids has proven to be a valuable and reliable technique for investigating such properties. The experimental data presented here was obtained from measurements of a transformer oil based ferrofluid, with measurements being performed over the frequency range 0.1-20 GHz and polarising fields 0-168 kA/m. In the case of transformer oil magnetic fluids, the normal measurement emphasis has been on the investigation of their dielectric properties, including the effects which lightning may have on these properties. Little has been reported on the measurement of the corresponding magnetic susceptibility, χ(ω), of such fluids and in this paper we address this fact. Thus we consider it worthwhile, in the case of a transformer with magnetic fluid transformer oil, being affected as a result of a lightening occurrence, to have knowledge of the fluids dynamic properties, at the microwave frequencies. In the process of determining the sample susceptibility profiles, it was found that the peak value of the χ″(ω) component, was approximately constant over the frequency range 2.4-6.3 GHz. From this it was determined that the fluid was effectively operating as a wideband absorber over a bandwidth of 3.9 GHz.

Normal stress effects on Knudsen flow

NASA Astrophysics Data System (ADS)

Eu, Byung Chan

2018-01-01

Normal stress effects are investigated on tube flow of a single-component non-Newtonian fluid under a constant pressure gradient in a constant temperature field. The generalized hydrodynamic equations are employed, which are consistent with the laws of thermodynamics. In the cylindrical tube flow configuration, the solutions of generalized hydrodynamic equations are exactly solvable and the flow velocity is obtained in a simple one-dimensional integral quadrature. Unlike the case of flow in the absence of normal stresses, the flow develops an anomaly in that the flow in the boundary layer becomes stagnant and the thickness of such a stagnant velocity boundary layer depends on the pressure gradient, the aspect ratio of the radius to the length of the tube, and the pressure (or density and temperature) at the entrance of the tube. The volume flow rate formula through the tube is derived for the flow. It generalizes the Knudsen flow rate formula to the case of a non-Newtonian stress tensor in the presence of normal stress differences. It also reduces to the Navier-Stokes theory formula in the low shear rate limit near equilibrium.

Idiopathic normal pressure hydrocephalus, quantitative EEG findings, and the cerebrospinal fluid tap test: a pilot study.

PubMed

Seo, Jong-Geun; Kang, Kyunghun; Jung, Ji-Young; Park, Sung-Pa; Lee, Maan-Gee; Lee, Ho-Won

2014-12-01

In this pilot study, we analyzed relationships between quantitative EEG measurements and clinical parameters in idiopathic normal pressure hydrocephalus patients, along with differences in these quantitative EEG markers between cerebrospinal fluid tap test responders and nonresponders. Twenty-six idiopathic normal pressure hydrocephalus patients (9 cerebrospinal fluid tap test responders and 17 cerebrospinal fluid tap test nonresponders) constituted the final group for analysis. The resting EEG was recorded and relative powers were computed for seven frequency bands. Cerebrospinal fluid tap test nonresponders, when compared with responders, showed a statistically significant increase in alpha2 band power at the right frontal and centrotemporal regions. Higher delta2 band powers in the frontal, central, parietal, and occipital regions and lower alpha1 band powers in the right temporal region significantly correlated with poorer cognitive performance. Higher theta1 band powers in the left parietal and occipital regions significantly correlated with gait dysfunction. And higher delta1 band powers in the right frontal regions significantly correlated with urinary disturbance. Our findings may encourage further research using quantitative EEG in patients with ventriculomegaly as a potential electrophysiological marker for predicting cerebrospinal fluid tap test responders. This study additionally suggests that the delta, theta, and alpha bands are statistically correlated with the severity of symptoms in idiopathic normal pressure hydrocephalus patients.

Development of an Aeroelastic Modeling Capability for Transient Nozzle Side Load Analysis

NASA Technical Reports Server (NTRS)

Wang, Ten-See; Zhao, Xiang; Zhang, Sijun; Chen, Yen-Sen

2013-01-01

Lateral nozzle forces are known to cause severe structural damage to any new rocket engine in development. Currently there is no fully coupled computational tool to analyze this fluid/structure interaction process. The objective of this study was to develop a fully coupled aeroelastic modeling capability to describe the fluid/structure interaction process during the transient nozzle operations. The aeroelastic model composes of three components: the computational fluid dynamics component based on an unstructured-grid, pressure-based computational fluid dynamics formulation, the computational structural dynamics component developed in the framework of modal analysis, and the fluid-structural interface component. The developed aeroelastic model was applied to the transient nozzle startup process of the Space Shuttle Main Engine at sea level. The computed nozzle side loads and the axial nozzle wall pressure profiles from the aeroelastic nozzle are compared with those of the published rigid nozzle results, and the impact of the fluid/structure interaction on nozzle side loads is interrogated and presented.

Numerical simulation of stress distribution in Inconel 718 components realized by metal injection molding during supercritical debinding

NASA Astrophysics Data System (ADS)

Agne, Aboubakry; Barrière, Thierry

2018-05-01

Metal injection molding (MIM) is a process combining advantages of thermoplastic injection molding and powder metallurgy process in order to manufacture components with complex and near net-shape geometries. The debinding of a green component can be performed in two steps, first by using solvent debinding in order to extract the organic part of the binder and then by thermal degradation of the rest of the binder. A shorter and innovative method for extracting an organic binder involves the use of supercritical fluid instead of a regular solvent. The debinding via a supercritical fluid was recently investigated to extract organic binders contained in components obtained by Metal Injection Molding. It consists to put the component in an enclosure subjected to high pressure and temperature. The supercritical fluid has various properties depending on these two conditions, e.g., density and viscosity. The high-pressure combined with the high temperature during the process affect the component structure. Three mechanisms contributing to the deformation of the component can been differentiated: thermal expansion, binder extraction and supercritical fluid effect on the outer surfaces of the component. If one supposes that, the deformation due to binder extraction is negligible, thermal expansion and the fluid effect are probably the main mechanisms that can produce several stress. A finite-element model, which couples fluid-structures interaction and structural mechanics, has been developed and performed on the Comsol Multiphysics® finite-element software platform allowed to estimate the stress distribution during the supercritical debinding of MIM component composed of Inconel 718 powders, polypropylene, polyethylene glycol and stearic acid as binder. The proposed numerical simulations allow the estimation of the stress distribution with respect to the processing parameters for MIM components during the supercritical debinding process using a stationary solver.

Alpha-fetoprotein as a tool to distinguish amniotic fluid from urine, vaginal discharge, and semen.

PubMed

Mor, Amir; Tal, Reshef; Haberman, Shoshana; McCalla, Sandra; Irani, Mohamad; Perlman, Jaqueline; Seifer, David B; Minkoff, Howard

2015-02-01

To estimate whether alpha-fetoprotein (AFP) can be used to distinguish amniotic fluid absorbed in sanitary pads from other similarly absorbed substances (semen, urine, and normal vaginal discharge). A prospective cohort study. Urine and amniotic fluid specimens were collected from 52 pregnant women admitted for labor. Semen specimens were collected from 17 men undergoing infertility evaluation. Alpha-fetoprotein concentrations were measured directly from urine, amniotic fluid, and semen and from pads instilled with samples from these specimens. Alpha-fetoprotein concentrations were also measured from pads absorbed with normal vaginal discharge collected from 27 pregnant women. Alpha-fetoprotein levels in amniotic fluid (245.38 ± 21.03 ng/mL, n = 52) were significantly higher than those measured in maternal urine (0.84 ± 0.17 ng/mL, n = 52, P < .001), or semen (1.52 ± 0.35 ng/mL, n = 17, P < .001). The same trend was seen when AFP was extracted from pads: amniotic fluid levels (19.44 ± 1.98 ng/mL, n=52) were significantly higher than those of urine (undetectable, n=52), semen (undetectable, n = 17), or normal vaginal discharge (0.53 ± 0.16 ng/mL, n = 27, P < .001). Receiver operator characteristic curve analysis demonstrated 96.2% sensitivity and 100% specificity for distinguishing the presence of amniotic fluid from normal vaginal discharge on sanitary pads (cutoff 3.88 ng/mL, area under the curve 0.99). When the diagnosis of rupture of membranes is in doubt, AFP levels can assist in differentiating amniotic fluid from other bodily fluids. A method that utilizes sanitary pads and an assay for AFP quantification may be an accurate and convenient way to confirm the diagnosis of rupture of membranes.

Rheological and Tribological Properties of Complex Biopolymer Solutions

NASA Astrophysics Data System (ADS)

Klossner, Rebecca Reese

2011-12-01

The rheological and tribological properties of an experimental synovial fluid model were investigated in order to determine the solution dynamics of the three most abundant macromolecules present in synovial fluid, the fluid that lubricates freely moving (synovial) joints. These components, hyaluronic acid (HA) and the plasma proteins, albumin and gamma-globulins are combined in a phosphate buffered saline solution (PBS) and subjected to steady shear rheology testing, as well as nanoindenter-based scratch testing, which allows for the study of the lubrication properties of the experimental synovial fluid model. Steady shear experiments, where the shear rate was increased from low to high, and then decreased from high to low, showed hysteresis in only protein containing solutions, whereas samples of HA in PBS behaved as a "typical" polyelectrolyte in solution. Subsequent rheological experiments on the synovial fluid model exhibited an increase in viscosity at low shear stresses, indicating that a structure was present at these low shear stresses, which was not found at higher shear stresses. This result is in agreement with studies conducted on the same model which show unusual rheological behavior at low shear rates. Low shear stresses can cause modifications to the external protein surface, resulting in their unfolding and creating many opportunities for the molecules to reorder themselves. As the proteins reorder themselves, the newly exposed hydrophobic patches will have a tendency to aggregate together, creating a network within the fluid, and, in turn causing the observed increased viscosity at low shear stresses. Additionally, an anti-inflammatory drug, hydroxychloroquine (HCQ) was added to the solutions. This addition diminishes the protein aggregation process substantially. Finally, the HA component of the synovial fluid model was replaced with a neutral polymer in order to examine the role of HA in synovial fluid. As suspected, the HA appears to have little impact on the actual aggregation process. Additionally, the relationship between the rheology and tribology of the SFM was studied through a series of nanoscratch tests using a Hysitron nanoindenter. The nanoindenter has the ability to measure both normal and lateral forces simultaneously, which gives an indication of the lubricity of the solution. The coefficient of friction values for solutions of varying protein concentrations were determined by dividing the lateral force by the normal force. Tribological testing of the synovial fluid model and modified solutions were carried out on spin-cast polyethylene and ultra high molecular weight polyethylene sheets. At lower molecular weight substrates, the film thickness limited the validity of the generated data, and with higher molecular weight surfaces, surface roughness effects were found to dominate the tribological response. Finally, the addition of HCQ does not have a large impact on the tribological data, indicating that the anti-inflammatory drug does not significantly impact the lubrication properties within the synovial fluid model. Finally, additional rheological studies of biopolymer solutions were conducted in which solutions containing chitosan, a natural, bioactive polymer, were characterized to determine their fitness for the electropsinning process. Chitosan fibers are difficult to electrospin, and through these studies, the entanglement concentration, a critical parameter for electrospinning, was determined. The generated rheological data provided a means to predict the morphology of the resulting nanofibers, and aspects of the difficulty in electrospinning chitosan were revealed.

Estimating Stresses, Fault Friction and Fluid Pressure from Topography and Coseismic Slip Models

NASA Astrophysics Data System (ADS)

Styron, R. H.; Hetland, E. A.

2014-12-01

Stress is a first-order control on the deformation state of the earth. However, stress is notoriously hard to measure, and researchers typically only estimate the directions and relative magnitudes of principal stresses, with little quantification of the uncertainties or absolute magnitude. To improve upon this, we have developed methods to constrain the full stress tensor field in a region surrounding a fault, including tectonic, topographic, and lithostatic components, as well as static friction and pore fluid pressure on the fault. Our methods are based on elastic halfspace techniques for estimating topographic stresses from a DEM, and we use a Bayesian approach to estimate accumulated tectonic stress, fluid pressure, and friction from fault geometry and slip rake, assuming Mohr-Coulomb fault mechanics. The nature of the tectonic stress inversion is such that either the stress maximum or minimum is better constrained, depending on the topography and fault deformation style. Our results from the 2008 Wenchuan event yield shear stresses from topography up to 20 MPa (normal-sinistral shear sense) and topographic normal stresses up to 80 MPa on the faults; tectonic stress had to be large enough to overcome topography to produce the observed reverse-dextral slip. Maximum tectonic stress is constrained to be >0.3 * lithostatic stress (depth-increasing), with a most likely value around 0.8, trending 90-110°E. Minimum tectonic stress is about half of maximum. Static fault friction is constrained at 0.1-0.4, and fluid pressure at 0-0.6 * total pressure on the fault. Additionally, the patterns of topographic stress and slip suggest that topographic normal stress may limit fault slip once failure has occurred. Preliminary results from the 2013 Balochistan earthquake are similar, but yield stronger constraints on the upper limits of maximum tectonic stress, as well as tight constraints on the magnitude of minimum tectonic stress and stress orientation. Work in progress on the Wasatch fault suggests that maximum tectonic stress may also be able to be constrained, and that some of the shallow rupture segmentation may be due in part to localized topographic loading. Future directions of this work include regions where high relief influences fault kinematics (such as Tibet).

Personal Computer Transport Analysis Program

NASA Technical Reports Server (NTRS)

DiStefano, Frank, III; Wobick, Craig; Chapman, Kirt; McCloud, Peter

2012-01-01

The Personal Computer Transport Analysis Program (PCTAP) is C++ software used for analysis of thermal fluid systems. The program predicts thermal fluid system and component transients. The output consists of temperatures, flow rates, pressures, delta pressures, tank quantities, and gas quantities in the air, along with air scrubbing component performance. PCTAP s solution process assumes that the tubes in the system are well insulated so that only the heat transfer between fluid and tube wall and between adjacent tubes is modeled. The system described in the model file is broken down into its individual components; i.e., tubes, cold plates, heat exchangers, etc. A solution vector is built from the components and a flow is then simulated with fluid being transferred from one component to the next. The solution vector of components in the model file is built at the initiation of the run. This solution vector is simply a list of components in the order of their inlet dependency on other components. The component parameters are updated in the order in which they appear in the list at every time step. Once the solution vectors have been determined, PCTAP cycles through the components in the solution vector, executing their outlet function for each time-step increment.

Hypocapnic but Not Metabolic Alkalosis Impairs Alveolar Fluid Reabsorption

PubMed Central

Myrianthefs, Pavlos M.; Briva, Arturo; Lecuona, Emilia; Dumasius, Vidas; Rutschman, David H.; Ridge, Karen M.; Baltopoulos, George J.; Sznajder, Jacob Iasha

2005-01-01

Acid-base disturbances, such as metabolic or respiratory alkalosis, are relatively common in critically ill patients. We examined the effects of alkalosis (hypocapnic or metabolic alkalosis) on alveolar fluid reabsorption in the isolated and continuously perfused rat lung model. We found that alveolar fluid reabsorption after 1 hour was impaired by low levels of CO2 partial pressure (PCO2; 10 and 20 mm Hg) independent of pH levels (7.7 or 7.4). In addition, PCO2 higher than 30 mm Hg or metabolic alkalosis did not have an effect on this process. The hypocapnia-mediated decrease of alveolar fluid reabsorption was associated with decreased Na,K-ATPase activity and protein abundance at the basolateral membranes of distal airspaces. The effect of low PCO2 on alveolar fluid reabsorption was reversible because clearance normalized after correcting the PCO2 back to normal levels. These data suggest that hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption. Conceivably, correction of hypocapnic alkalosis in critically ill patients may contribute to the normalization of lung ability to clear edema. PMID:15764729

Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption.

PubMed

Myrianthefs, Pavlos M; Briva, Arturo; Lecuona, Emilia; Dumasius, Vidas; Rutschman, David H; Ridge, Karen M; Baltopoulos, George J; Sznajder, Jacob Iasha

2005-06-01

Acid-base disturbances, such as metabolic or respiratory alkalosis, are relatively common in critically ill patients. We examined the effects of alkalosis (hypocapnic or metabolic alkalosis) on alveolar fluid reabsorption in the isolated and continuously perfused rat lung model. We found that alveolar fluid reabsorption after 1 hour was impaired by low levels of CO2 partial pressure (PCO2; 10 and 20 mm Hg) independent of pH levels (7.7 or 7.4). In addition, PCO2 higher than 30 mm Hg or metabolic alkalosis did not have an effect on this process. The hypocapnia-mediated decrease of alveolar fluid reabsorption was associated with decreased Na,K-ATPase activity and protein abundance at the basolateral membranes of distal airspaces. The effect of low PCO2 on alveolar fluid reabsorption was reversible because clearance normalized after correcting the PCO2 back to normal levels. These data suggest that hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption. Conceivably, correction of hypocapnic alkalosis in critically ill patients may contribute to the normalization of lung ability to clear edema.

Computer program for computing the properties of seventeen fluids. [cryogenic liquids

NASA Technical Reports Server (NTRS)

Brennan, J. A.; Friend, D. G.; Arp, V. D.; Mccarty, R. D.

1992-01-01

The present study describes modifications and additions to the MIPROPS computer program for calculating the thermophysical properties of 17 fluids. These changes include adding new fluids, new properties, and a new interface to the program. The new program allows the user to select the input and output parameters and the units to be displayed for each parameter. Fluids added to the MIPROPS program are carbon dioxide, carbon monoxide, deuterium, helium, normal hydrogen, and xenon. The most recent modifications to the MIPROPS program are the addition of viscosity and thermal conductivity correlations for parahydrogen and the addition of the fluids normal hydrogen and xenon. The recently added interface considerably increases the program's utility.

MMP-2 as an early synovial biomarker for cranial cruciate ligament disease in dogs.

PubMed

Boland, L; Danger, R; Cabon, Q; Rabillard, M; Brouard, S; Bouvy, B; Gauthier, O

2014-01-01

To measure the activity of matrix metalloproteinases (MMP)-2 and -9 in synovial fluid from the stifle joints of dogs with cranial cruciate ligament (CrCL) rupture and to compare that to values from contralateral stifle joints and dogs with clinically normal stifle joints. Additionally, the C-reactive protein (CRP) levels were also measured. Fourteen large breed dogs with unilateral CrCL rupture and 11 large breed normal dogs were included in this prospective clinical study. Synovial fluid was collected from CrCL-ruptured stifle joints, contralateral clinically normal stifle joints of the same dogs, and stifle joints of normal dogs. Serum was also collected. Synovial fluid activities of MMP-2 and MMP-9 and serum CRP level were measured. The MMP-2 activity in synovial fluid was significantly higher in CrCL-ruptured joints compared to contralateral joints and to stifles from normal dogs. There was no significant difference in activity of MMP-2 in contralateral joints of CrCL-ruptured dogs compared to normal dogs. Both serum CRP level and MMP-9 activity did not differ significantly between the studied conditions. It was confirmed that MMP-2 activity is significantly related to CrCL rupture, but there was a failure to demonstrate any significant increase in the contralateral joints compared to the stifle joints of normal dogs. The MMP-2 involvement in progressing CrCL disease still has to be defined.

Slow deformation of intervertebral discs.

PubMed

Broberg, K B

1993-01-01

Intervertebral discs exhibit pronounced time-dependent deformations when subjected to load variations. These deformations are caused by fluid flow to and from the disc and by viscoelastic deformation of annulus fibres. The fluid flow is caused by differences between mechanical and osmotic pressure. A mechanical model of lumbar disc functions allows one to calculate both the extent of fluid flow and its implications for disc height as well as the role played by viscoelastic deformation of annulus fibres. From such calculations changes in body height are estimated. Experimental results already documented in the literature offer bases for the determination of the parameters involved. Body height variations are studied, both those related to normal diurnal rhythmicity and those related to somewhat exceptional circumstances. The normal diurnal fluid flow is found to be about +/- 40% of the disc fluid content late in the evening. Viscoelastic deformation of annulus fibres contributes approximately one quarter of the height change obtained after several hours normal activity, but dominates during the first hour.

High wavenumber Raman spectroscopy in the characterization of urinary metabolites of normal subjects, oral premalignant and malignant patients

NASA Astrophysics Data System (ADS)

Brindha, Elumalai; Rajasekaran, Ramu; Aruna, Prakasarao; Koteeswaran, Dornadula; Ganesan, Singaravelu

2017-01-01

Urine has emerged as one of the diagnostically potential bio fluids, as it has many metabolites. As the concentration and the physiochemical properties of the urinary metabolites may vary under pathological transformation, Raman spectroscopic characterization of urine has been exploited as a significant tool in identifying several diseased conditions, including cancers. In the present study, an attempt was made to study the high wavenumber (HWVN) Raman spectroscopic characterization of urine samples of normal subjects, oral premalignant and malignant patients. It is concluded that the urinary metabolites flavoproteins, tryptophan and phenylalanine are responsible for the observed spectral variations between the normal and abnormal groups. Principal component analysis-based linear discriminant analysis was carried out to verify the diagnostic potentiality of the present technique. The discriminant analysis performed across normal and oral premalignant subjects classifies 95.6% of the original and 94.9% of the cross-validated grouped cases correctly. In the second analysis performed across normal and oral malignant groups, the accuracy of the original and cross-validated grouped cases was 96.4% and 92.1% respectively. Similarly, the third analysis performed across three groups, normal, oral premalignant and malignant groups, classifies 93.3% and 91.2% of the original and cross-validated grouped cases correctly.

The properties and causes of rippling in quasi-perpendicular collisionless shock fronts

NASA Astrophysics Data System (ADS)

Lowe, R. E.; Burgess, D.

2003-03-01

The overall structure of quasi-perpendicular, high Mach number collisionless shocks is controlled to a large extent by ion reflection at the shock ramp. Departure from a strictly one-dimensional structure is indicated by simulation results showing that the surface of such shocks is rippled, with variations in the density and all field components. We present a detailed analysis of these shock ripples, using results from a two-dimensional hybrid (particle ions, electron fluid) simulation. The process that generates the ripples is poorly understood, because the large gradients at the shock ramp make it difficult to identify instabilities. Our analysis reveals new features of the shock ripples, which suggest the presence of a surface wave mode dominating the shock normal magnetic field component of the ripples, as well as whistler waves excited by reflected ions.

[Membrane model of the regulation of proliferation: the theory and interpretation of an experiment].

PubMed

Volkov, E I

1983-04-01

The role of cell surface physical organization in the cell cycle regulation is analyzed within the framework of the earlier proposed theory (Chernavskii et al., 1982). Two models of cell surface are considered: hard-frame fluid-mosaic model (latticemosaic) and the fluid-mosaic one. The former deals with normal cells. The existence of integral carcasse or "frame" which is formed by the essential part of cross-linked membrane components and may have at least two different conformational states is hypothesized. The second model describes membranes of tumour cells. With the latter theory any mitogen (excluding the restoration of nutrient depletion) reduces the mechanical tensile strength of the frame and stimulates the general structural rearrangement of the plasma membrane. There are only two conformational transitions during the cell cycle which serve as signals for the beginning of S and M phases. If the values of tensile strength are great enough and therefore the conformational transitions are impossible, the cells pass into the resting (prereplicative--G01, or premitotical--G02) state. Three types of experiments are interpreted in the proposed theory: a) on differences in the action of growth factors on normal and tumour cell cycle, b) on the necessary condition for mitogenicity of lectins, c) on the stimulation of proliferation by mechanical deformation of cells.

Integrated acoustic phase separator and multiphase fluid composition monitoring apparatus and method

DOEpatents

Sinha, Dipen N.

2016-01-12

An apparatus and method for down hole gas separation from the multiphase fluid flowing in a wellbore or a pipe, for determining the quantities of the individual components of the liquid and the flow rate of the liquid, and for remixing the component parts of the fluid after which the gas volume may be measured, without affecting the flow stream, are described. Acoustic radiation force is employed to separate gas from the liquid, thereby permitting measurements to be separately made for these two components; the liquid (oil/water) composition is determined from ultrasonic resonances; and the gas volume is determined from capacitance measurements. Since the fluid flows around and through the component parts of the apparatus, there is little pressure difference, and no protection is required from high pressure differentials.

Integrated acoustic phase separator and multiphase fluid composition monitoring apparatus and method

DOEpatents

Sinha, Dipen N

2014-02-04

An apparatus and method for down hole gas separation from the multiphase fluid flowing in a wellbore or a pipe, for determining the quantities of the individual components of the liquid and the flow rate of the liquid, and for remixing the component parts of the fluid after which the gas volume may be measured, without affecting the flow stream, are described. Acoustic radiation force is employed to separate gas from the liquid, thereby permitting measurements to be separately made for these two components; the liquid (oil/water) composition is determined from ultrasonic resonances; and the gas volume is determined from capacitance measurements. Since the fluid flows around and through the component parts of the apparatus, there is little pressure difference, and no protection is required from high pressure differentials.

Mechanical membrane for the separation of a paramagnetic constituent from a fluid

DOEpatents

Maurice, David

2017-05-02

The disclosure provides an apparatus and method for the separation of a paramagnetic component from a mixture using a mechanical membrane apparatus. The mechanical membrane comprises a supporting material having a plurality of pores where each pore is surrounded by a plurality of magnetic regions. The magnetic regions augment a magnetic field on one side of the supporting material while mitigating the field to near zero on the opposite side. In operation, a flow of fluid such as air comprising a paramagnetic component such as O.sub.2 is directed toward the mechanical membrane, and the paramagnetic component is typically attracted toward a magnetic field surrounding a pore while dimagnetic components such as N.sub.2 are generally repelled. As some portion of the fluid passes through the plurality of magnetic apertures to the opposite side of the mechanical membrane, the mechanical membrane generates a fluid enriched in the paramagnetic component. Alternately, the magnetic field may act to repel the paramagnetic component while diamagnetic components such as N.sub.2 are generally unaffected and pass to the opposite side of the mechanical membrane.

Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome.

PubMed

Chang, Dong W; Hayashi, Shinichi; Gharib, Sina A; Vaisar, Tomas; King, S Trevor; Tsuchiya, Mitsuhiro; Ruzinski, John T; Park, David R; Matute-Bello, Gustavo; Wurfel, Mark M; Bumgarner, Roger; Heinecke, Jay W; Martin, Thomas R

2008-10-01

Acute lung injury causes complex changes in protein expression in the lungs. Whereas most prior studies focused on single proteins, newer methods allowing the simultaneous study of many proteins could lead to a better understanding of pathogenesis and new targets for treatment. The purpose of this study was to examine the changes in protein expression in the bronchoalveolar lavage fluid (BALF) of patients during the course of the acute respiratory distress syndrome (ARDS). Using two-dimensional difference gel electrophoresis (DIGE), the expression of proteins in the BALF from patients on Days 1 (n = 7), 3 (n = 8), and 7 (n = 5) of ARDS were compared with findings in normal volunteers (n = 9). The patterns of protein expression were analyzed using principal component analysis (PCA). Biological processes that were enriched in the BALF proteins of patients with ARDS were identified using Gene Ontology (GO) analysis. Protein networks that model the protein interactions in the BALF were generated using Ingenuity Pathway Analysis. An average of 991 protein spots were detected using DIGE. Of these, 80 protein spots, representing 37 unique proteins in all of the fluids, were identified using mass spectrometry. PCA confirmed important differences between the proteins in the ARDS and normal samples. GO analysis showed that these differences are due to the enrichment of proteins involved in inflammation, infection, and injury. The protein network analysis showed that the protein interactions in ARDS are complex and redundant, and revealed unexpected central components in the protein networks. Proteomics and protein network analysis reveals the complex nature of lung protein interactions in ARDS. The results provide new insights about protein networks in injured lungs, and identify novel mediators that are likely to be involved in the pathogenesis and progression of acute lung injury.

Continuous TDEM for monitoring shale hydraulic fracturing

NASA Astrophysics Data System (ADS)

Yan, Liang-Jun; Chen, Xiao-Xiong; Tang, Hao; Xie, Xing-Bing; Zhou, Lei; Hu, Wen-Bao; Wang, Zhong-Xin

2018-03-01

Monitoring and delineating the spatial distribution of shale fracturing is fundamentally important to shale gas production. Standard monitoring methods, such as time-lapse seismic, cross-well seismic and micro-seismic methods, are expensive, timeconsuming, and do not show the changes in the formation with time. The resistivities of hydraulic fracturing fluid and reservoir rocks were measured. The results suggest that the injection fluid and consequently the injected reservoir are characterized by very low resistivity and high chargeability. This allows using of the controlled-source electromagnetic method (CSEM) to monitor shale gas hydraulic fracturing. Based on the geoelectrical model which was proposed according to the well-log and seismic data in the test area the change rule of the reacted electrical field was studied to account for the change of shale resistivity, and then the normalized residual resistivity method for time lapse processing was given. The time-domain electromagnetic method (TDEM) was used to continuously monitor the shale gas fracturing at the Fulin shale gas field in southern China. A high-power transmitter and multi-channel transient electromagnetic receiver array were adopted. 9 h time series of Ex component of 224 sites which were laid out on the surface and over three fracturing stages of a horizontal well at 2800 m depth was recorded. After data processing and calculation of the normalized resistivity residuals, the changes in the Ex signal were determined and a dynamic 3D image of the change in resistivity was constructed. This allows modeling the spatial distribution of the fracturing fluid. The model results suggest that TDEM is promising for monitoring hydraulic fracturing of shale.

Sensitivity of Induced Seismic Sequences to Rate-and-State Frictional Processes

NASA Astrophysics Data System (ADS)

Kroll, Kayla A.; Richards-Dinger, Keith B.; Dieterich, James H.

2017-12-01

It is well established that subsurface injection of fluids increases pore fluid pressures that may lead to shear failure along a preexisting fault surface. Concern among oil and gas, geothermal, and carbon storage operators has risen dramatically over the past decade due to the increase in the number and magnitude of induced earthquakes. Efforts to mitigate the risk associated with injection-induced earthquakes include modeling of the interaction between fluids and earthquake faults. Here we investigate this relationship with simulations that couple a geomechanical reservoir model and RSQSim, a physics-based earthquake simulator. RSQSim employs rate- and state-dependent friction (RSF) that enables the investigation of the time-dependent nature of earthquake sequences. We explore the effect of two RSF parameters and normal stress on the spatiotemporal characteristics of injection-induced seismicity. We perform >200 simulations to systematically investigate the effect of these model components on the evolution of induced seismicity sequences and compare the spatiotemporal characteristics of our synthetic catalogs to observations of induced earthquakes. We find that the RSF parameters control the ability of seismicity to migrate away from the injection well, the total number and maximum magnitude of induced events. Additionally, the RSF parameters control the occurrence/absence of premonitory events. Lastly, we find that earthquake stress drops can be modulated by the normal stress and/or the RSF parameters. Insight gained from this study can aid in further development of models that address best practice protocols for injection operations, site-specific models of injection-induced earthquakes, and probabilistic hazard and risk assessments.

Sensitivity of Induced Seismic Sequences to Rate-and-State Frictional Processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kroll, Kayla A.; Richards-Dinger, Keith B.; Dieterich, James H.

It is well established that subsurface injection of fluids increases pore fluid pressures that may lead to shear failure along a preexisting fault surface. Concern among oil and gas, geothermal, and carbon storage operators has risen dramatically over the past decade due to the increase in the number and magnitude of induced earthquakes. Efforts to mitigate the risk associated with injection-induced earthquakes include modeling of the interaction between fluids and earthquake faults. Here we investigate this relationship with simulations that couple a geomechanical reservoir model and RSQSim, a physics-based earthquake simulator. RSQSim employs rate- and state-dependent friction (RSF) that enablesmore » the investigation of the time-dependent nature of earthquake sequences. We explore the effect of two RSF parameters and normal stress on the spatiotemporal characteristics of injection-induced seismicity. We perform >200 simulations to systematically investigate the effect of these model components on the evolution of induced seismicity sequences and compare the spatiotemporal characteristics of our synthetic catalogs to observations of induced earthquakes. We find that the RSF parameters control the ability of seismicity to migrate away from the injection well, the total number and maximum magnitude of induced events. Additionally, the RSF parameters control the occurrence/absence of premonitory events. Finally, we find that earthquake stress drops can be modulated by the normal stress and/or the RSF parameters. Insight gained from this study can aid in further development of models that address best practice protocols for injection operations, site-specific models of injection-induced earthquakes, and probabilistic hazard and risk assessments.« less

Sensitivity of Induced Seismic Sequences to Rate-and-State Frictional Processes

DOE PAGES

Kroll, Kayla A.; Richards-Dinger, Keith B.; Dieterich, James H.

2017-11-09

It is well established that subsurface injection of fluids increases pore fluid pressures that may lead to shear failure along a preexisting fault surface. Concern among oil and gas, geothermal, and carbon storage operators has risen dramatically over the past decade due to the increase in the number and magnitude of induced earthquakes. Efforts to mitigate the risk associated with injection-induced earthquakes include modeling of the interaction between fluids and earthquake faults. Here we investigate this relationship with simulations that couple a geomechanical reservoir model and RSQSim, a physics-based earthquake simulator. RSQSim employs rate- and state-dependent friction (RSF) that enablesmore » the investigation of the time-dependent nature of earthquake sequences. We explore the effect of two RSF parameters and normal stress on the spatiotemporal characteristics of injection-induced seismicity. We perform >200 simulations to systematically investigate the effect of these model components on the evolution of induced seismicity sequences and compare the spatiotemporal characteristics of our synthetic catalogs to observations of induced earthquakes. We find that the RSF parameters control the ability of seismicity to migrate away from the injection well, the total number and maximum magnitude of induced events. Additionally, the RSF parameters control the occurrence/absence of premonitory events. Finally, we find that earthquake stress drops can be modulated by the normal stress and/or the RSF parameters. Insight gained from this study can aid in further development of models that address best practice protocols for injection operations, site-specific models of injection-induced earthquakes, and probabilistic hazard and risk assessments.« less

Emergency department management of gastro-enteritis in Australia and New Zealand.

PubMed

Schutz, Jacquie; Babl, Franz E; Sheriff, Nisa; Borland, Meredith

2008-10-01

Comparison of clinical practice guideline (CPG) recommendations and reported physician management of gastro-enteritis at Paediatric Research in Emergency Departments International Collaborative (PREDICT) network sites as a baseline for further randomised controlled trials. Two part survey comprising: (i) review of CPGs from PREDICT sites for gastro-enteritis; and (ii) survey of senior emergency department physicians regarding the management of gastro-enteritis. All 11 PREDICT sites participated. Nine CPGs were available with three sites using a common CPG. For moderate dehydration, eight CPGs advocated nasogastric (NG) rehydration in preference to intravenous (IV) rehydration. The IV route was reserved for severe dehydration or failed NG rehydration. In the second component of the survey, 78 of 83 (94%) physicians responded. In moderate dehydration, 82% of respondents used NG rehydration. In severe dehydration, 86% used IV fluids; 12% used NG and 3% an initial IV bolus followed by NG fluid. Serum electrolytes were measured universally with IV fluid use and by 22% using NG rehydration. The IV fluid bolus was with normal saline (86%). Fifty-four per cent used anti-emetics 'rarely' or 'sometimes'. The commonest agents were ondansetron (60%) and metoclopramide (29%). CPG recommendations and physician practice for the management of gastro-enteritis were similar across PREDICT sites with a focus on NG for moderate dehydration and IV for severe dehydration. A variety of fluids and administration rates were used. Anti-emetics were used infrequently. The efficacy and safety of newer anti-emetics should be explored in collaborative studies. Collaborative development of new CPGs should be considered to simplify fluid regimens.

Treatment with unsaponifiable extracts of avocado and soybean increases TGF-beta1 and TGF-beta2 levels in canine joint fluid.

PubMed

Altinel, Levent; Saritas, Z Kadir; Kose, Kamil Cagri; Pamuk, Kamuran; Aksoy, Yusuf; Serteser, Mustafa

2007-02-01

Avocado and soya unsaponifiables (ASU) are plant extracts used as a slow-acting antiarthritic agent. ASU stimulate the synthesis of matrix components by chondrocytes, probably by increasing the production of transforming growth factor-beta (TGF-beta). TGF-beta is expressed by chondrocytes and osteoblasts and is present in cartilage matrix. This study investigates the effect of ASU treatment on the levels of two isoforms of TGFbeta, TGF-beta1 and TGF-beta2, in the knee joint fluid using a canine model. Twenty-four outbred dogs were divided into three groups. The control animals were given a normal diet, while the treated animals were given 300 mg ASU every three days or every day. Joint fluid samples were obtained prior to treatment, and at the end of every month (up to three months). TGF-beta1 and TGF-beta2 levels were measured using a quantitative sandwich enzyme immunoassay technique. ASU treatment caused an increase in TGF-beta1 and TGF-beta2 levels in the joint fluid when compared to controls. The different doses did not cause a significant difference in joint fluid TGF levels. TGF-beta1 levels in the treated animals reached maximum values at the end of the second month and then decreased after the third month, while TGF-beta2 levels showed a marginal increase during the first two months, followed by a marked increase at the end of the third month. In conclusion, ASU increased both TGF-beta1 and TGF-beta2 levels in knee joint fluid.

Burn wound sepsis may be promoted by a failure of local antibacterial host defenses.

PubMed Central

Deitch, E A; Bridges, R M; Dobke, M; McDonald, J C

1987-01-01

Little attention has been focused on the local burn wound environment, even though burn wound sepsis is a common cause of death in the burn victim. To characterize the effect of the local burn wound environment on neutrophil function and metabolism, the opsonic activity of blister fluid specimens against Pseudomonas aeruginosa was measured as was the effect of blister fluid on control neutrophil oxygen consumption using preopsonized zymosan and f-met-leu-phe (FMLP) as stimuli. Blister fluid did not support the killing of P. aeruginosa by normal neutrophils as well as normal serum. Additionally, blister fluid inhibited zymosan-stimulated, but not FMLP-stimulated, neutrophil oxygen consumption. The inhibitory effect of blister fluid on zymosan-stimulated oxygen consumption correlated with the extent of complement activation, measured as C3d or C3AI (p less than 0.01). That blister fluid did not inhibit the FMLP-mediated respiratory burst supports the concept that the blister fluid inhibitory effect on the zymosan-mediated respiratory burst was mediated through the complement receptor. These findings that blister fluid can affect the bactericidal and metabolic activity of normal neutrophils support the concept that cellular function can be altered by the microenvironment in which the cells are bathed. This potential impairment of host defenses within the burn wound could predispose the burn victim to burn wound sepsis. PMID:3115207

Bowel perforation detection using metabolic fluorescent chlorophylls

NASA Astrophysics Data System (ADS)

Han, Jung Hyun; Jo, Young Goun; Kim, Jung Chul; Choi, Sujeong; Kang, Hoonsoo; Kim, Yong-Chul; Hwang, In-Wook

2016-03-01

Thus far, there have been tries of detection of disease using fluorescent materials. We introduce the chlorophyll derivatives from food plants, which have longer-wavelength emissions (at >650 nm) than those of fluorescence of tissues and organs, for detection of bowel perforation. To figure out the possibility of fluorescence spectroscopy as a monitoring sensor of bowel perforation, fluorescence from organs of rodent models, intestinal and peritoneal fluids of rodent models and human were analyzed. In IVIS fluorescence image of rodent abdominal organ, visualization of perforated area only was possible when threshold of image is extremely finely controlled. Generally, both perforated area of bowel and normal bowel which filled with large amount of chlorophyll derivatives were visualized with fluorescence. The fluorescence from chlorophyll derivatives penetrated through the normal bowel wall makes difficult to distinguish perforation area from normal bowel with direct visualization of fluorescence. However, intestinal fluids containing chlorophyll derivatives from food contents can leak from perforation sites in situation of bowel perforation. It may show brighter and longer-wavelength regime emissions of chlorophyll derivatives than those of pure peritoneal fluid or bioorgans. Peritoneal fluid mixed with intestinal fluids show much brighter emissions in longer wavelength (at>650 nm) than those of pure peritoneal fluid. In addition, irrigation fluid, which is used for the cleansing of organ and peritoneal cavity, made of mixed intestinal and peritoneal fluid diluted with physiologic saline also can be monitored bowel perforation during surgery.

NIST Libraries of Peptide Fragmentation Mass Spectra Databass

National Institute of Standards and Technology Data Gateway

SRD 4 NIST Libraries of Peptide Fragmentation Mass Spectra Databass (PC database for purchase)   Interactive computer program for predicting thermodynamic and transport properties of pure fluids and fluid mixtures containing up to 20 components. The components are selected from a database of 196 components, mostly hydrocarbons.

Palliative care - fluid, food, and digestion

MedlinePlus

... gov/ency/patientinstructions/000531.htm Palliative care - fluid, food, and digestion To use the sharing features on ... When Your Body Has Problems Handling Fluids and Food It is normal for a person who has ...

Maintenance Fluid Therapy: Isotonic Versus Hypotonic Solutions.

PubMed

Hansen, Bernie; Vigani, Alessio

2017-03-01

The goal of maintenance fluid therapy in small animals is to replace normal ongoing losses of water and salts when oral intake is withheld. Hospitalized dogs and cats may have multiple stimuli for antidiuretic hormone release that disrupt normal osmoregulation and predispose to water retention. Severe illness promotes retention of both sodium and water as edema. Commercially available fluids have electrolyte concentrations that are very different from dietary maintenance requirements, and potential consequences include development of hypoosmolality, edema, or both when excesses of water or sodium are administered. Suggestions for tailoring fluid administration toward specific goals are provided. Copyright © 2016 Elsevier Inc. All rights reserved.

Frictional stability and earthquake triggering during fluid pressure stimulation of an experimental fault

NASA Astrophysics Data System (ADS)

Scuderi, M. M.; Collettini, C.; Marone, C.

2017-11-01

It is widely recognized that the significant increase of M > 3.0 earthquakes in Western Canada and the Central United States is related to underground fluid injection. Following injection, fluid overpressure lubricates the fault and reduces the effective normal stress that holds the fault in place, promoting slip. Although, this basic physical mechanism for earthquake triggering and fault slip is well understood, there are many open questions related to induced seismicity. Models of earthquake nucleation based on rate- and state-friction predict that fluid overpressure should stabilize fault slip rather than trigger earthquakes. To address this controversy, we conducted laboratory creep experiments to monitor fault slip evolution at constant shear stress while the effective normal stress was systematically reduced via increasing fluid pressure. We sheared layers of carbonate-bearing fault gouge in a double direct shear configuration within a true-triaxial pressure vessel. We show that fault slip evolution is controlled by the stress state acting on the fault and that fluid pressurization can trigger dynamic instability even in cases of rate strengthening friction, which should favor aseismic creep. During fluid pressurization, when shear and effective normal stresses reach the failure condition, accelerated creep occurs in association with fault dilation; further pressurization leads to an exponential acceleration with fault compaction and slip localization. Our work indicates that fault weakening induced by fluid pressurization can overcome rate strengthening friction resulting in fast acceleration and earthquake slip. Our work points to modifications of the standard model for earthquake nucleation to account for the effect of fluid overpressure and to accurately predict the seismic risk associated with fluid injection.

Fluid Structural Analysis of Human Cerebral Aneurysm Using Their Own Wall Mechanical Properties

PubMed Central

Valencia, Alvaro; Burdiles, Patricio; Ignat, Miguel; Mura, Jorge; Rivera, Rodrigo; Sordo, Juan

2013-01-01

Computational Structural Dynamics (CSD) simulations, Computational Fluid Dynamics (CFD) simulation, and Fluid Structure Interaction (FSI) simulations were carried out in an anatomically realistic model of a saccular cerebral aneurysm with the objective of quantifying the effects of type of simulation on principal fluid and solid mechanics results. Eight CSD simulations, one CFD simulation, and four FSI simulations were made. The results allowed the study of the influence of the type of material elements in the solid, the aneurism's wall thickness, and the type of simulation on the modeling of a human cerebral aneurysm. The simulations use their own wall mechanical properties of the aneurysm. The more complex simulation was the FSI simulation completely coupled with hyperelastic Mooney-Rivlin material, normal internal pressure, and normal variable thickness. The FSI simulation coupled in one direction using hyperelastic Mooney-Rivlin material, normal internal pressure, and normal variable thickness is the one that presents the most similar results with respect to the more complex FSI simulation, requiring one-fourth of the calculation time. PMID:24151523

Drag reduction at a plane wall

NASA Technical Reports Server (NTRS)

Hill, D. C.

1993-01-01

The objective is to determine by analytical means how drag on a plane wall may be modified favorably using a minimal amount of flow information - preferably only information at the wall. What quantities should be measured? How should that information be assimilated in order to arrive at effective control? As a prototypical problem, incompressible, viscous flow, governed by the Navier-Stokes equations, past a plane wall at which the no-slip condition was modified was considered. The streamwise and spanwise velocity components are required to be zero, but the normal component is to be specified according to some control law. The challenge is to choose the wall-normal velocity component based on flow conditions at the wall so that the mean drag is as small as possible. There can be no net mass flux through the wall, and the total available control energy is constrained. A turbulent flow is highly unsteady and has detailed spatial structure. The mean drag on the wall is the integral over the wall of the local shear forces exerted by the fluid, which is then averaged in time; it is a 'macroscopic' property of the flow. It is not obvious how unsteady boundary control is to be applied in order to modify the mean flow most effectively, especially in view of the non- self-adjoint nature of the governing equations. An approximate analytical solution to the suboptimal scheme is pursued.

Separation of supercritical slab-fluids to form aqueous fluid and melt components in subduction zone magmatism.

PubMed

Kawamoto, Tatsuhiko; Kanzaki, Masami; Mibe, Kenji; Matsukage, Kyoko N; Ono, Shigeaki

2012-11-13

Subduction-zone magmatism is triggered by the addition of H(2)O-rich slab-derived components: aqueous fluid, hydrous partial melts, or supercritical fluids from the subducting slab. Geochemical analyses of island arc basalts suggest two slab-derived signatures of a melt and a fluid. These two liquids unite to a supercritical fluid under pressure and temperature conditions beyond a critical endpoint. We ascertain critical endpoints between aqueous fluids and sediment or high-Mg andesite (HMA) melts located, respectively, at 83-km and 92-km depths by using an in situ observation technique. These depths are within the mantle wedge underlying volcanic fronts, which are formed 90 to 200 km above subducting slabs. These data suggest that sediment-derived supercritical fluids, which are fed to the mantle wedge from the subducting slab, react with mantle peridotite to form HMA supercritical fluids. Such HMA supercritical fluids separate into aqueous fluids and HMA melts at 92 km depth during ascent. The aqueous fluids are fluxed into the asthenospheric mantle to form arc basalts, which are locally associated with HMAs in hot subduction zones. The separated HMA melts retain their composition in limited equilibrium with the surrounding mantle. Alternatively, they equilibrate with the surrounding mantle and change the major element chemistry to basaltic composition. However, trace element signatures of sediment-derived supercritical fluids remain more in the melt-derived magma than in the fluid-induced magma, which inherits only fluid-mobile elements from the sediment-derived supercritical fluids. Separation of slab-derived supercritical fluids into melts and aqueous fluids can elucidate the two slab-derived components observed in subduction zone magma chemistry.

Separation of supercritical slab-fluids to form aqueous fluid and melt components in subduction zone magmatism

PubMed Central

Kawamoto, Tatsuhiko; Kanzaki, Masami; Mibe, Kenji; Ono, Shigeaki

2012-01-01

Subduction-zone magmatism is triggered by the addition of H2O-rich slab-derived components: aqueous fluid, hydrous partial melts, or supercritical fluids from the subducting slab. Geochemical analyses of island arc basalts suggest two slab-derived signatures of a melt and a fluid. These two liquids unite to a supercritical fluid under pressure and temperature conditions beyond a critical endpoint. We ascertain critical endpoints between aqueous fluids and sediment or high-Mg andesite (HMA) melts located, respectively, at 83-km and 92-km depths by using an in situ observation technique. These depths are within the mantle wedge underlying volcanic fronts, which are formed 90 to 200 km above subducting slabs. These data suggest that sediment-derived supercritical fluids, which are fed to the mantle wedge from the subducting slab, react with mantle peridotite to form HMA supercritical fluids. Such HMA supercritical fluids separate into aqueous fluids and HMA melts at 92 km depth during ascent. The aqueous fluids are fluxed into the asthenospheric mantle to form arc basalts, which are locally associated with HMAs in hot subduction zones. The separated HMA melts retain their composition in limited equilibrium with the surrounding mantle. Alternatively, they equilibrate with the surrounding mantle and change the major element chemistry to basaltic composition. However, trace element signatures of sediment-derived supercritical fluids remain more in the melt-derived magma than in the fluid-induced magma, which inherits only fluid-mobile elements from the sediment-derived supercritical fluids. Separation of slab-derived supercritical fluids into melts and aqueous fluids can elucidate the two slab-derived components observed in subduction zone magma chemistry. PMID:23112158

7 CFR 1150.113 - Fluid milk products.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 9 2014-01-01 2013-01-01 true Fluid milk products. 1150.113 Section 1150.113... AGREEMENTS AND ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.113 Fluid milk products. Fluid milk products means those milk products normally...

7 CFR 1150.113 - Fluid milk products.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 9 2012-01-01 2012-01-01 false Fluid milk products. 1150.113 Section 1150.113... Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.113 Fluid milk products. Fluid milk products means those milk products normally...

7 CFR 1150.113 - Fluid milk products.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 9 2013-01-01 2013-01-01 false Fluid milk products. 1150.113 Section 1150.113... AGREEMENTS AND ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.113 Fluid milk products. Fluid milk products means those milk products normally...

7 CFR 1150.113 - Fluid milk products.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 9 2011-01-01 2011-01-01 false Fluid milk products. 1150.113 Section 1150.113... Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.113 Fluid milk products. Fluid milk products means those milk products normally...

7 CFR 1150.113 - Fluid milk products.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Fluid milk products. 1150.113 Section 1150.113... Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.113 Fluid milk products. Fluid milk products means those milk products normally...

Proteomics detection of S100A6 in tumor tissue interstitial fluid and evaluation of its potential as a biomarker of cholangiocarcinoma.

PubMed

Onsurathum, Sudarat; Haonon, Ornuma; Pinlaor, Porntip; Pairojkul, Chawalit; Khuntikeo, Narong; Thanan, Raynoo; Roytrakul, Sittiruk; Pinlaor, Somchai

2018-04-01

Tumor interstitial fluid contains tumor-specific proteins that may be useful biomarkers for cancers. In this study, we identified proteins present in cholangiocarcinoma interstitial fluid. Proteins derived from three samples of tumor interstitial fluid and paired samples of adjacent normal interstitial fluid from cholangiocarcinoma patients were subjected to two-dimensional liquid chromatography with tandem mass spectrometry. Candidate proteins were selected based on a greater than twofold change in expression levels between tumor interstitial fluid and normal interstitial fluid. Upregulation of six proteins in tumor interstitial fluid, including S100 calcium binding protein A6 (S100A6), S100 calcium binding protein A9, aldo-keto reductase family 1 member C4, neuropilin-1, 14-3-3 zeta/delta, and triosephosphate isomerase was assessed by western blot and immunohistochemistry. Their potential as markers was evaluated in human cholangiocarcinoma tissue arrays, and in serum using enzyme-linked immunosorbent assay. Expression of S100A6 was higher in tumor interstitial fluid than in normal interstitial fluid and showed the highest positive rate (98.96%) in cholangiocarcinoma tissues. Serum levels of S100A6 did not differ between cholangitis and cholangiocarcinoma patients, but were significantly higher than in healthy individuals ( p < 0.0001). In cholangiocarcinoma cases, S100A6 level was associated with vascular invasion ( p = 0.007) and could distinguish cholangiocarcinoma patients from healthy individuals as effectively as the carbohydrate antigen 19-9. In addition, potential for drug treatment targeting S100A6 and other candidate proteins was also demonstrated using STITCH analysis. In conclusion, proteomics analysis of tumor interstitial fluid could be a new approach for biomarker discovery, and S100A6 is a potential risk marker for screening of cholangiocarcinoma.

Synovial fluid progenitors expressing CD90+ from normal but not osteoarthritic joints undergo chondrogenic differentiation without micro-mass culture.

PubMed

Krawetz, Roman J; Wu, Yiru Elizabeth; Martin, Liam; Rattner, Jerome B; Matyas, John R; Hart, David A

2012-01-01

Mesenchymal progenitor cells (MPCs) can differentiate into osteoblasts, adipocytes, and chondrocytes, and are in part responsible for maintaining tissue integrity. Recently, a progenitor cell population has been found within the synovial fluid that shares many similarities with bone marrow MPCs. These synovial fluid MPCs (sfMPCs) share the ability to differentiate into bone and fat, with a bias for cartilage differentiation. In this study, sfMPCs were isolated from human and canine synovial fluid collected from normal individuals and those with osteoarthritis (human: clinician-diagnosed, canine: experimental) to compare the differentiation potential of CD90+ vs. CD90- sfMPCs, and to determine if CD90 (Thy-1) is a predictive marker of synovial fluid progenitors with chondrogenic capacity in vitro. sfMPCs were derived from synovial fluid from normal and OA knee joints. These cells were induced to differentiate into chondrocytes and analyzed using quantitative PCR, immunofluorescence, and electron microscopy. The CD90+ subpopulation of sfMPCs had increased chondrogenic potential compared to the CD90- population. Furthermore, sfMPCs derived from healthy joints did not require a micro-mass step for efficient chondrogenesis. Whereas sfMPCs from OA synovial fluid retain the ability to undergo chondrogenic differentiation, they require micro-mass culture conditions. Overall, this study has demonstrated an increased chondrogenic potential within the CD90+ fraction of human and canine sfMPCs and that this population of cells derived from healthy normal joints do not require a micro-mass step for efficient chondrogenesis, while sfMPCs obtained from OA knee joints do not differentiate efficiently into chondrocytes without the micro-mass procedure. These results reveal a fundamental shift in the chondrogenic ability of cells isolated from arthritic joint fluids, and we speculate that the mechanism behind this change of cell behavior is exposure to the altered milieu of the OA joint fluid, which will be examined in further studies.

Sphingolipid Metabolism Correlates with Cerebrospinal Fluid Beta Amyloid Levels in Alzheimer’s Disease

PubMed Central

Fonteh, Alfred N.; Ormseth, Cora; Chiang, Jiarong; Cipolla, Matthew; Arakaki, Xianghong; Harrington, Michael G.

2015-01-01

Sphingolipids are important in many brain functions but their role in Alzheimer’s disease (AD) is not completely defined. A major limit is availability of fresh brain tissue with defined AD pathology. The discovery that cerebrospinal fluid (CSF) contains abundant nanoparticles that include synaptic vesicles and large dense core vesicles offer an accessible sample to study these organelles, while the supernatant fluid allows study of brain interstitial metabolism. Our objective was to characterize sphingolipids in nanoparticles representative of membrane vesicle metabolism, and in supernatant fluid representative of interstitial metabolism from study participants with varying levels of cognitive dysfunction. We recently described the recruitment, diagnosis, and CSF collection from cognitively normal or impaired study participants. Using liquid chromatography tandem mass spectrometry, we report that cognitively normal participants had measureable levels of sphingomyelin, ceramide, and dihydroceramide species, but that their distribution differed between nanoparticles and supernatant fluid, and further differed in those with cognitive impairment. In CSF from AD compared with cognitively normal participants: a) total sphingomyelin levels were lower in nanoparticles and supernatant fluid; b) levels of ceramide species were lower in nanoparticles and higher in supernatant fluid; c) three sphingomyelin species were reduced in the nanoparticle fraction. Moreover, three sphingomyelin species in the nanoparticle fraction were lower in mild cognitive impairment compared with cognitively normal participants. The activity of acid, but not neutral sphingomyelinase was significantly reduced in the CSF from AD participants. The reduction in acid sphingomylinase in CSF from AD participants was independent of depression and psychotropic medications. Acid sphingomyelinase activity positively correlated with amyloid β42 concentration in CSF from cognitively normal but not impaired participants. In dementia, altered sphingolipid metabolism, decreased acid sphingomyelinase activity and its lost association with CSF amyloid β42 concentration, underscores the potential of sphingolipids as disease biomarkers, and acid sphingomyelinase as a target for AD diagnosis and/or treatment. PMID:25938590

Reduction of turbomachinery noise

NASA Technical Reports Server (NTRS)

Waitz, Ian A. (Inventor); Hayden, Belva J. (Inventor); Ingard, K. Uno (Inventor); Brookfield, John M. (Inventor); Sell, Julian (Inventor)

1999-01-01

In the invention, propagating broad band and tonal acoustic components of noise characteristic of interaction of a turbomachine blade wake, produced by a turbomachine blade as the blade rotates, with a turbomachine component downstream of the rotating blade, are reduced. This is accomplished by injection of fluid into the blade wake through a port in the rotor blade. The mass flow rate of the fluid injected into the blade wake is selected to reduce the momentum deficit of the wake to correspondingly increase the time-mean velocity of the wake and decrease the turbulent velocity fluctuations of the wake. With this fluid injection, reduction of both propagating broad band and tonal acoustic components of noise produced by interaction of the blade wake with a turbomachine component downstream of the rotating blade is achieved. In a further noise reduction technique, boundary layer fluid is suctioned into the turbomachine blade through a suction port on the side of the blade that is characterized as the relatively low-pressure blade side. As with the fluid injection technique, the mass flow rate of the fluid suctioned into the blade is here selected to reduce the momentum deficit of the wake to correspondingly increase the time-mean velocity of the wake and decrease the turbulent velocity fluctuations of the wake; reduction of both propagating broad band and tonal acoustic components of noise produced by interaction of the blade wake with a turbomachine component downstream of the rotating blade is achieved with this suction technique. Blowing and suction techniques are also provided in the invention for reducing noise associated with the wake produced by fluid flow around a stationary blade upstream of a rotating turbomachine.

Shear waves in inhomogeneous, compressible fluids in a gravity field.

PubMed

Godin, Oleg A

2014-03-01

While elastic solids support compressional and shear waves, waves in ideal compressible fluids are usually thought of as compressional waves. Here, a class of acoustic-gravity waves is studied in which the dilatation is identically zero, and the pressure and density remain constant in each fluid particle. These shear waves are described by an exact analytic solution of linearized hydrodynamics equations in inhomogeneous, quiescent, inviscid, compressible fluids with piecewise continuous parameters in a uniform gravity field. It is demonstrated that the shear acoustic-gravity waves also can be supported by moving fluids as well as quiescent, viscous fluids with and without thermal conductivity. Excitation of a shear-wave normal mode by a point source and the normal mode distortion in realistic environmental models are considered. The shear acoustic-gravity waves are likely to play a significant role in coupling wave processes in the ocean and atmosphere.

Fluid design studies of integrated modular engine system

NASA Technical Reports Server (NTRS)

Frankenfield, Bruce; Carek, Jerry

1993-01-01

A study was performed to develop a fluid system design and show the feasibility of constructing an integrated modular engine (IME) configuration, using an expander cycle engine. The primary design goal of the IME configuration was to improve the propulsion system reliability. The IME fluid system was designed as a single fault tolerant system, while minimizing the required fluid components. This study addresses the design of the high pressure manifolds, turbopumps and thrust chambers for the IME configuration. A physical layout drawing was made, which located each of the fluid system components, manifolds and thrust chambers. Finally, a comparison was made between the fluid system designs of an IME system and a non-network (clustered) engine system.

Intra-articular corticosteroid preparations: different characteristics and their effect during inflammation induced by monosodium urate crystals in the rat subcutaneous air pouch.

PubMed

Rull, M; Clayburne, G; Sieck, M; Schumacher, H R

2003-09-01

To examine the effects of three commonly used intra-articular depot corticosteroid preparations tested in a rat air pouch model and their effect against monosodium urate (MSU) crystal-induced inflammation. Rheumatologists use intra-articular corticosteroid preparations to relieve pain and inflammation of acute monoarthritis without really knowing their effects on the synovial fluid and membrane or the differences between distinct preparations. This work compares the effect of three commonly used corticosteroid preparations in vivo, showing that they behave differently. A subcutaneous air pouch was formed in male Sprague-Dawley rats. A first group of 6-day-old air pouches were injected with 10 ml of 6 mg/ml normal saline solution, 6 mg/ml betamethasone containing both depot betamethasone acetate and soluble betamethasone phosphate (Celestone) in 9 ml of normal saline solution, 20 mg/ml of prednisolone tebutate (Hydeltra) in 9 ml of normal saline solution or 20 mg/ml of triamcinolone hexacetonide (Aristospan) in 9 ml of normal saline solution. A second group (group 2) of air pouches were injected with 15 mg of synthetic MSU crystals and 24 h later they were reinjected with 1 ml of the same three corticosteroid suspensions. For each condition four rats were killed at 6, 24, 48 h and 7 days. Pouch fluid and tissue were analysed. In the first 6 h after normal saline solution or corticosteroid injection into the air pouch there were mildly increased leucocyte counts in the air pouch fluid. Betamethasone-injected pouches showed no cells in the fluid after 6 h and no crystals after 24 h, triamcinolone-injected pouches still showed rare cells at 7 days. Both triamcinolone and prednisolone crystals persisted in higher numbers and lasted longer in the fluid than did betamethasone (P<0.05). In group 2 MSU crystal phagocytosis in the fluid was decreased in the betamethasone- (P<0.01), prednisolone- (P<0.003) and triamcinolone- (P<0.006) injected pouches when compared with the MSU crystal-injected pouches alone. Pouches injected with MSU crystals alone showed the most intense tissue inflammation at all times. After MSU, betamethasone-injected pouches had a rapid but mild decrease in the number of lining cells and inflammation. In contrast, triamcinolone- and prednisolone-injected pouches showed a very thin tissue with few or no vessels and almost no inflammation at 7 days. The pouches injected with MSU crystals and any of the corticoid preparations had three times more tophus-like structures and persistent crystals identified than the ones injected with MSU crystals alone. Each of the corticosteroid preparations by themselves produced very mild transient inflammation. The betamethasone preparation with a soluble steroid component had a quicker but milder anti-inflammatory effect on MSU crystal-induced inflammation. In contrast to the doses used, prednisolone tebutate and triamcinolone hexacetonide preparations dramatically suppressed urate crystal-induced inflammation at 7 days, but both produced atrophy and necrosis of the membrane, yielding a very thin membrane with almost no vessels. When used for MSU crystal-induced inflammation these corticosteroid preparations suppressed some aspects of inflammation but may actually promote the persistence of MSU crystals and the formation of tophi.

Normal versus anomalous self-diffusion in two-dimensional fluids: memory function approach and generalized asymptotic Einstein relation.

PubMed

Shin, Hyun Kyung; Choi, Bongsik; Talkner, Peter; Lee, Eok Kyun

2014-12-07

Based on the generalized Langevin equation for the momentum of a Brownian particle a generalized asymptotic Einstein relation is derived. It agrees with the well-known Einstein relation in the case of normal diffusion but continues to hold for sub- and super-diffusive spreading of the Brownian particle's mean square displacement. The generalized asymptotic Einstein relation is used to analyze data obtained from molecular dynamics simulations of a two-dimensional soft disk fluid. We mainly concentrated on medium densities for which we found super-diffusive behavior of a tagged fluid particle. At higher densities a range of normal diffusion can be identified. The motion presumably changes to sub-diffusion for even higher densities.

Normal versus anomalous self-diffusion in two-dimensional fluids: Memory function approach and generalized asymptotic Einstein relation

NASA Astrophysics Data System (ADS)

Shin, Hyun Kyung; Choi, Bongsik; Talkner, Peter; Lee, Eok Kyun

2014-12-01

Based on the generalized Langevin equation for the momentum of a Brownian particle a generalized asymptotic Einstein relation is derived. It agrees with the well-known Einstein relation in the case of normal diffusion but continues to hold for sub- and super-diffusive spreading of the Brownian particle's mean square displacement. The generalized asymptotic Einstein relation is used to analyze data obtained from molecular dynamics simulations of a two-dimensional soft disk fluid. We mainly concentrated on medium densities for which we found super-diffusive behavior of a tagged fluid particle. At higher densities a range of normal diffusion can be identified. The motion presumably changes to sub-diffusion for even higher densities.

Influence of fluids on the abrasion of silicon by diamond

NASA Technical Reports Server (NTRS)

Danyluk, S.

1982-01-01

Silicon wafers ((100)-p-type) were abraded at room temperature in acetone, absolute ethanol and water by a pyramid diamond and the resulting groove depth was measured as a function of normal force on the diamond and the absorbed fluids, while all other experimental conditions were held constant. The groove depth rates are in the ratio of 1:2:3 for water, absolute ethanol, and acetone, respectively, for a constant normal force. The groove depth rate is lower when the normal force is decreased. The silicon abraded in the presence of water was chipped as expected for a classical brittle material while the surfaces abraded in the other two fluids showed ductile ploughing as the main mechanism for silicon removal.

On hydrodynamic phase field models for binary fluid mixtures

NASA Astrophysics Data System (ADS)

Yang, Xiaogang; Gong, Yuezheng; Li, Jun; Zhao, Jia; Wang, Qi

2018-05-01

Two classes of thermodynamically consistent hydrodynamic phase field models have been developed for binary fluid mixtures of incompressible viscous fluids of possibly different densities and viscosities. One is quasi-incompressible, while the other is incompressible. For the same binary fluid mixture of two incompressible viscous fluid components, which one is more appropriate? To answer this question, we conduct a comparative study in this paper. First, we visit their derivation, conservation and energy dissipation properties and show that the quasi-incompressible model conserves both mass and linear momentum, while the incompressible one does not. We then show that the quasi-incompressible model is sensitive to the density deviation of the fluid components, while the incompressible model is not in a linear stability analysis. Second, we conduct a numerical investigation on coarsening or coalescent dynamics of protuberances using the two models. We find that they can predict quite different transient dynamics depending on the initial conditions and the density difference although they predict essentially the same quasi-steady results in some cases. This study thus cast a doubt on the applicability of the incompressible model to describe dynamics of binary mixtures of two incompressible viscous fluids especially when the two fluid components have a large density deviation.

A numerical investigation of head waves and leaky modes in fluid- filled boreholes.

USGS Publications Warehouse

Paillet, Frederick L.; Cheng, C.H.

1986-01-01

Although synthetic borehole seismograms can be computed for a wide range of borehole conditions, the physical nature of shear and compressional head waves in fluid-filled boreholes is poorly understood. Presents a series of numerical experiments designed to explain the physical mechanisms controlling head-wave propagation in boreholes. These calculations demonstrate the existence of compressional normal modes equivalent to shear normal modes, or pseudo-Rayleigh waves, with sequential cutoff frequencies spaced between the cutoff frequencies for the shear normal modes.-from Authors

Aeroelastic Modeling of a Nozzle Startup Transient

NASA Technical Reports Server (NTRS)

Wang, Ten-See; Zhao, Xiang; Zhang, Sijun; Chen, Yen-Sen

2014-01-01

Lateral nozzle forces are known to cause severe structural damage to any new rocket engine in development during test. While three-dimensional, transient, turbulent, chemically reacting computational fluid dynamics methodology has been demonstrated to capture major side load physics with rigid nozzles, hot-fire tests often show nozzle structure deformation during major side load events, leading to structural damages if structural strengthening measures were not taken. The modeling picture is incomplete without the capability to address the two-way responses between the structure and fluid. The objective of this study is to develop a tightly coupled aeroelastic modeling algorithm by implementing the necessary structural dynamics component into an anchored computational fluid dynamics methodology. The computational fluid dynamics component is based on an unstructured-grid, pressure-based computational fluid dynamics formulation, while the computational structural dynamics component is developed under the framework of modal analysis. Transient aeroelastic nozzle startup analyses at sea level were performed, and the computed transient nozzle fluid-structure interaction physics presented,

Origin and Timing of Dauphiné Twins Using Fluid Inclusions in Quartz-Cement Fractures in Sandstones from Diagenetic Environments

NASA Astrophysics Data System (ADS)

Fall, A.; Ukar, E.; Laubach, S.

2016-12-01

Dauphiné twins in quartz are widespread in many tectonometamorphic environments. Under diagenetic temperatures (<200°C) and burial depths less than 5 km Dauphiné twins are also common in isolated fracture quartz deposits spanning between fracture walls in low-porosity quartz-cemented sandstones. The twin boundaries coincide with fracture wall-normal fluid inclusion trails. The association of Dauphiné twins and fluid inclusion trails from which temperature and possibly timing can be inferred provides a way to research mechanism and timing of twinning, and potentially the magnitude of paleostrain and stress in some diagenetic settings. Using examples from East Texas and Colorado cores, we show that twins are associated with crack-seal microstructure and fluid inclusions. Fracture wall-parallel and wall-normal inclusion trails contain coexisting aqueous and hydrocarbon gas inclusions, so homogenization temperatures of aqueous inclusions, ranging from 130°C to 159°C in the East Texas Basin, and from 162°C to 176°C in the Piceance Basin, record true trapping temperatures. Inclusions in wall-normal trails are large and irregularly shaped compared to those in wall-parallel trails, but both show similar liquid-to-vapor ratios. Trapping temperatures for wall-normal inclusion trails are usually higher than those in the wall-parallel trails. Wall-normal fluid inclusion assemblage temperatures typically match the highest temperatures of wall-parallel assemblages trapped during sequential widening, but not necessarily the most recent. In context of burial histories for these samples, this temperature pattern implies that wall-normal assemblages form at discrete times during or after crack-seal fracture widening. Stacking transmitted light images with scanning electron microscope cathodoluminescence (SEM-CL) and electron backscattered diffraction (EBSD) images demonstrates that the twin boundaries are localized along wall-normal inclusion trails. Localization in isolated, potentially high-stress quartz deposits in fractures is compatible with a mechanical origin for these Dauphiné twins. Punctuated temperature values and discrepant sizes and shapes of inclusions in wall-normal trails imply that twinning is a by-product of the formation of the wall-normal inclusion trails.

Structural and tribometric characterization of biomimetically inspired synthetic "insect adhesives"

PubMed Central

Speidel, Matthias W; Kleemeier, Malte; Hartwig, Andreas; Rischka, Klaus; Ellermann, Angelika; Daniels, Rolf

2017-01-01

Background: Based on previous chemical analyses of insect tarsal adhesives, we prepared 12 heterogeneous synthetic emulsions mimicking the polar/non-polar principle, analysed their microscopical structure and tested their adhesive, frictional, and rheological properties. Results: The prepared emulsions varied in their consistency from solid rubber-like, over soft elastic, to fluid (watery or oily). With droplet sizes >100 nm, all the emulsions belonged to the common type of macroemulsions. The emulsions of the first generation generally showed broader droplet-size ranges compared with the second generation, especially when less defined components such as petrolatum or waxes were present in the lipophilic fraction of the first generation of emulsions. Some of the prepared emulsions showed a yield point and were Bingham fluids. Tribometric adhesion was tested via probe tack tests. Compared with the "second generation" (containing less viscous components), the "first generation" emulsions were much more adhesive (31–93 mN), a finding attributable to their highly viscous components, i.e., wax, petrolatum, gelatin and poly(vinyl alcohol). In the second generation emulsions, we attained much lower adhesivenesses, ranging between 1–18 mN. The adhesive performance was drastically reduced in the emulsions that contained albumin as the protein component or that lacked protein. Tribometric shear tests were performed at moderate normal loads. Our measured friction forces (4–93 mN in the first and 0.1–5.8 mN in the second generation emulsions) were comparatively low. Differences in shear performance were related to the chemical composition and emulsion structure. Conclusion: By varying their chemical composition, synthetic heterogeneous adhesive emulsions can be adjusted to have diverse consistencies and are able to mimic certain rheological and tribological properties of natural tarsal insect adhesives. PMID:28144564

[Study on the dynamic model with supercritical CO2 fluid extracting the lipophilic components in Panax notoginseng].

PubMed

Duan, Xian-Chun; Wang, Yong-Zhong; Zhang, Jun-Ru; Luo, Huan; Zhang, Heng; Xia, Lun-Zhu

2011-08-01

To establish a dynamics model for extracting the lipophilic components in Panax notoginseng with supercritical carbon dioxide (CO2). Based on the theory of counter-flow mass transfer and the molecular mass transfer between the material and the supercritical CO2 fluid under differential mass-conservation equation, a dynamics model was established and computed to compare forecasting result with the experiment process. A dynamics model has been established for supercritical CO2 to extract the lipophilic components in Panax notoginseng, the computed result of this model was consistent with the experiment process basically. The supercritical fluid extract dynamics model established in this research can expound the mechanism in the extract process of which lipophilic components of Panax notoginseng dissolve the mass transfer and is tallied with the actual extract process. This provides certain instruction for the supercritical CO2 fluid extract' s industrialization enlargement.

Method and system for providing cooling for turbine components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morgan, Victor John; Lacy, Benjamin Paul

2016-08-16

A system for providing cooling for a turbine component that includes an outer surface exposed to combustion gases is provided. A component base includes at least one fluid supply passage coupleable to a source of cooling fluid. At least one feed passage communicates with the at least one fluid supply passage. At least one delivery channel communicates with the at least one feed passage. At least one cover layer covers the at least one feed passage and the at least one delivery channel, defining at least in part the component outer surface. At least one discharge passage extends to themore » outer surface. A diffuser section is defined in at least one of the at least one delivery channel and the at least one discharge passage, such that a fluid channeled through the system is diffused prior to discharge adjacent the outer surface.« less

Photonic crystal waveguide-based biosensor for detection of diseases

NASA Astrophysics Data System (ADS)

Chopra, Harshita; Kaler, Rajinder S.; Painam, Balveer

2016-07-01

A biosensor is a device that is used to detect the analytes or molecules of a sample by means of a binding mechanism. A two-dimensional photonic crystal waveguide-based biosensor is designed with a diamond-shaped ring resonator and two waveguides: a bus waveguide and a drop waveguide. The sensing mechanism is based on change in refractive index of the analytes, leading to a shift in the peak resonant wavelength. This mechanism can be used in the field of biomedical treatment where different body fluids such as blood, tears, saliva, or urine can be used as the analyte in which different components of the fluid can be detected. It can also be used to differentiate between the cell lines of a normal and an unhealthy human being. Average value of quality factor for this device comes out to be 1082.2063. For different analytes used, the device exhibits enhanced sensitivity and, hence, it is useful for the detection of diseases.

Embryonic Cerebrospinal Fluid Increases Neurogenic Activity in the Brain Ventricular-Subventricular Zone of Adult Mice.

PubMed

Alonso, Maria I; Lamus, Francisco; Carnicero, Estela; Moro, Jose A; de la Mano, Anibal; Fernández, Jose M F; Desmond, Mary E; Gato, Angel

2017-01-01

Neurogenesis is a very intensive process during early embryonic brain development, becoming dramatically restricted in the adult brain in terms of extension and intensity. We have previously demonstrated the key role of embryonic cerebrospinal fluid (CSF) in developing brain neurogenic activity. We also showed that cultured adult brain neural stem cells (NSCs) remain competent when responding to the neurogenic influence of embryonic CSF. However, adult CSF loses its neurogenic inductive properties. Here, by means of an organotypic culture of adult mouse brain sections, we show that local administration of embryonic CSF in the subventricular zone (SVZ) niche is able to trigger a neurogenic program in NSCs. This leads to a significant increase in the number of non-differentiated NSCs, and also in the number of new neurons which show normal migration, differentiation and maturation. These new data reveal that embryonic CSF activates adult brain NSCs, supporting the previous idea that it contains key instructive components which could be useful in adult brain neuroregenerative strategies.

Embryonic Cerebrospinal Fluid Increases Neurogenic Activity in the Brain Ventricular-Subventricular Zone of Adult Mice

PubMed Central

Alonso, Maria I.; Lamus, Francisco; Carnicero, Estela; Moro, Jose A.; de la Mano, Anibal; Fernández, Jose M. F.; Desmond, Mary E.; Gato, Angel

2017-01-01

Neurogenesis is a very intensive process during early embryonic brain development, becoming dramatically restricted in the adult brain in terms of extension and intensity. We have previously demonstrated the key role of embryonic cerebrospinal fluid (CSF) in developing brain neurogenic activity. We also showed that cultured adult brain neural stem cells (NSCs) remain competent when responding to the neurogenic influence of embryonic CSF. However, adult CSF loses its neurogenic inductive properties. Here, by means of an organotypic culture of adult mouse brain sections, we show that local administration of embryonic CSF in the subventricular zone (SVZ) niche is able to trigger a neurogenic program in NSCs. This leads to a significant increase in the number of non-differentiated NSCs, and also in the number of new neurons which show normal migration, differentiation and maturation. These new data reveal that embryonic CSF activates adult brain NSCs, supporting the previous idea that it contains key instructive components which could be useful in adult brain neuroregenerative strategies. PMID:29311854

Three dimensional contact/impact methodology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kulak, R.F.

1987-01-01

The simulation of three-dimensional interface mechanics between reactor components and structures during static contact or dynamic impact is necessary to realistically evaluate their structural integrity to off-normal loads. In our studies of postulated core energy release events, we have found that significant structure-structure interactions occur in some reactor vessel head closure designs and that fluid-structure interactions occur within the reactor vessel. Other examples in which three-dimensional interface mechanics play an important role are: (1) impact response of shipping casks containing spent fuel, (2) whipping pipe impact on reinforced concrete panels or pipe-to-pipe impact after a pipe break, (3) aircraft crashmore » on secondary containment structures, (4) missiles generated by turbine failures or tornados, and (5) drops of heavy components due to lifting accidents. The above is a partial list of reactor safety problems that require adequate treatment of interface mechanics and are discussed in this paper.« less

The source and significance of argon isotopes in fluid inclusions from areas of mineralization

NASA Astrophysics Data System (ADS)

Kelley, S.; Turner, G.; Butterfield, A. W.; Shepherd, T. J.

1986-09-01

Argon isotopes in fluid inclusions in quartz veins associated with granite-hosted tungsten mineralization in the southwest and north of England have been investigated in detail by the 40Ar- 39Ar technique. The natural argon is present as a number of discrete components which can be identified through correlations with 39Ar, 38Ar and 37Ar induced by neutron bombardment of potassium, chlorine and calcium. The potassium-correlated component arises principally from in situ decay of potassium in solid phases in the inclusions. In the case of the Hemerdon tungsten deposit of southwest England the phases responsible are small (≈ 25 μm) captive authigenic micas which are shown to have been deposited from a fluid 268 ± 20 Ma ago, shortly after the emplacement of the host granite. The chlorine-correlated component is present in the brines which constitute the fluid phase of the inclusions. The argon in these hydrothermal fluids is made up in part of "parentless" or "excess" 40Ar leached from surrounding crustal rocks, and in part of dissolved ancient atmospheric argon. Absolute concentrations of both atmospheric and excess components in the brine can be estimated from ( 40ArCl ) ratios and independent determinations of the salinity of the inclusions. The absolute concentrations of the atmospheric argon are close to those found in modern meteoric water, while those of the excess component can be interpreted in terms of the degree of interaction betwen the circulating fluids and country rock. A calcium-correlated component, with a much higher ratio of excess to atmospheric argon than that in the brine, was found to be a dominant phase in one sample from the Hemerdon deposit, indicating the presence of a solid phase (probably a CaSO 4 daughter mineral). Inclusions of this composition represent fluids which have had a more prolonged interaction- with crustal rocks. The results obtained from this study provide a systematization and a framework for future multi-component argon studies of fluid inclusions, together with an indication of the wide range of information which can be inferred.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Detwiler, Russell

Fractures provide flow paths that can potentially lead to fast migration of fluids or contaminants. A number of energy-­related applications involve fluid injections that significantly perturb both the pressures and chemical composition of subsurface fluids. These perturbations can cause both mechanical deformation and chemical alteration of host rocks with potential for significant changes in permeability. In fractured rock subjected to coupled chemical and mechanical stresses, it can be difficult to predict the sign of permeability changes, let alone the magnitude. This project integrated experimental and computational studies to improve mechanistic understanding of these coupled processes and develop and test predictivemore » models and monitoring techniques. The project involved three major components: (1) study of two-­phase flow processes involving mass transfer between phases and dissolution of minerals along fracture surfaces (Detwiler et al., 2009; Detwiler, 2010); (2) study of fracture dissolution in fractures subjected to normal stresses using experimental techniques (Ameli, et al., 2013; Elkhoury et al., 2013; Elkhoury et al., 2014) and newly developed computational models (Ameli, et al., 2014); (3) evaluation of electrical resistivity tomography (ERT) as a method to detect and quantify gas leakage through a fractured caprock (Breen et al., 2012; Lochbuhler et al., 2014). The project provided support for one PhD student (Dr. Pasha Ameli; 2009-­2013) and partially supported a post-­doctoral scholar (Dr. Jean Elkhoury; 2010-­2013). In addition, the project provided supplemental funding to support collaboration with Dr. Charles Carrigan at Lawrence Livermore National Laboratory in connection with (3) and supported one MS student (Stephen Breen; 2011-­2013). Major results from each component of the project include the following: (1) Mineral dissolution in fractures occupied by two fluid phases (e.g., oil-­water or water-­CO{sub 2}) causes changes in local capillary forces and redistribution of fluids. These coupled processes enhance channel formation and the potential for development of fast flow paths through fractures. (2) Dissolution in fractures subjected to normal stress can result in behaviors ranging from development of dissolution channels and rapid permeability increases to fracture healing and significant permeability decreases. The timescales associated with advective transport of dissolved ions in the fracture, mineral dissolution rates, and diffusion within the adjacent porous matrix dictate the sign and magnitude of the resulting permeability changes. Furthermore, a high--resolution mechanistic model that couples elastic deformation of contacts and aperture-­dependent dissolution rates predicts the range of observed behaviors reasonably well. (3) ERT has potential as a tool for monitoring gas leakage in deep formations. Using probabilistic inversion methods further enhances the results by providing uncertainty estimates of inverted parameters.« less

Sweating and Body Odor

MedlinePlus

... This fluid is composed mainly of water and salt. Apocrine glands produce a milky fluid that most commonly is secreted when you're under emotional stress. This fluid is odorless until it combines with bacteria found normally on your skin. By Mayo Clinic ...

Method and apparatus for adapting steady flow with cyclic thermodynamics

DOEpatents

Swift, Gregory W.; Reid, Robert S.; Ward, William C.

2000-01-01

Energy transfer apparatus has a resonator for supporting standing acoustic waves at a selected frequency with a steady flow process fluid thermodynamic medium and a solid medium having heat capacity. The fluid medium and the solid medium are disposed within the resonator for thermal contact therebetween and for relative motion therebetween. The relative motion is produced by a first means for producing a steady velocity component and second means for producing an oscillating velocity component at the selected frequency and concomitant wavelength of the standing acoustic wave. The oscillating velocity and associated oscillating pressure component provide energy transfer between the steady flow process fluid and the solid medium as the steady flow process fluid moves through the resonator.

Amniocentesis

MedlinePlus

... trisomy 18 Infections in the amniotic fluid Normal Results A normal result means: No genetic or chromosome ... even if amniocentesis results are normal. What Abnormal Results Mean An abnormal result may mean your baby ...

Phoresis in fluids.

PubMed

Brenner, Howard

2011-12-01

This paper presents a unified theory of phoretic phenomena in single-component fluids. Simple formulas are given for the phoretic velocities of small inert force-free non-Brownian particles migrating through otherwise quiescent single-component gases and liquids and animated by a gradient in the fluid's temperature (thermophoresis), pressure (barophoresis), density (pycnophoresis), or any combination thereof. The ansatz builds upon a recent paper [Phys. Rev. E 84, 046309 (2011)] concerned with slip of the fluid's mass velocity at solid surfaces--that is, with phenomena arising from violations of the classical no-slip fluid-mechanical boundary condition. Experimental and other data are cited in support of the phoretic model developed herein.

Adverse perinatal outcomes in borderline amniotic fluid index.

PubMed

Jamal, Ashraf; Kazemi, Maryam; Marsoosi, Vajiheh; Eslamian, Laleh

2016-11-01

Normal amniotic fluid predicts normal placental function, fetal growth and fetal well-being. To determine adverse pregnancy outcomes in borderline amniotic fluid index (AFI). Pregnant women (37-40 wks) with diagnosis of borderline AFI between December 2012 and August 2014 were identified. Antepartum, intrapartum and neonatal data were collected and compared with those of pregnant women with normal AFI. An AFI less than 8 and more than 5 cm was defined for borderline AFI. Pregnancy outcomes included Cesarean section for non-reassuring fetal heart rate, meconium stained amniotic fluid, 5-min Apgar score <7, low birth weight, umbilical cord blood pH at term and NICU admission. Gestational age at delivery in pregnancies with borderline AFI was significantly lower than normal AFI. Cesarean section rate for non-reassuring fetal heart rate in women of borderline AFI was significantly higher and there was an increased incidence of birth weight less than 10 th percentile for gestation age in borderline AFI group. Incidence of low Apgar score and low umbilical artery pH in pregnancies with borderline AFI was significantly higher than women with normal AFI. There were no significant difference in the rate of NICU admission and meconium staining in both groups. There are significant differences for adverse pregnancy outcomes , such as Cesarean section due to non-reassuring fetal heart rate, birth weight less than 10 th percentile for gestation age, low 5 min Apgar score and low umbilical artery pH between pregnancies with borderline and normal AFI.

PROTEIN METABOLISM AND EXCHANGE AS INFLUENCED BY CONSTRICTION OF THE VENA CAVA

PubMed Central

McKee, Frank W.; Hyatt, Robert E.; Wilt, William G.; Tishkoff, Garson H.; Whipple, George H.

1949-01-01

Further studies of ascitic fluid production and related factors in dogs with constriction of the vena cava above the diaphragm are reported. Whole dog plasma given intravenously to such animals produces a rise in circulating plasma protein to normal levels, but increases the output of ascitic fluid with a loss of protein via the ascites equivalent to 72, 76, and 65 per cent respectively, of the injected protein. Forced ingestion of water in excess of the test animal's normal needs and desires produces no significant changes in the circulating plasma protein level or in ascitic fluid production. Amino acid growth mixtures given intravenously in distilled water cause weight loss, elevation of circulating plasma proteins, a slightly negative nitrogen balance, but no ascitic fluid production. Amino acid growth mixtures given intravenously in normal saline cause depression of the circulating plasma proteins, negative nitrogen balance, and significant ascitic fluid production. Ascitic fluid given intravenously to the test animals causes a marked depression of circulating plasma proteins, a marked increase in ascitic fluid production containing the equivalent of 116 and 98 per cent of the injected protein, and a negative nitrogen balance. Ascitic fluid given orally produces a marked depression of circulating plasma proteins, and a marked increase in ascitic fluid secretion, containing the equivalent of 66, 66, and 54 per cent respectively, of the ingested protein. Sodium chloride is a dominant factor in some of these experiments where abundant ascites production is recorded. Protein levels and intake are important, but take second place to sodium. Ascitic fluids show electrophoretic patterns which are almost identical to the plasma patterns. The A/G ratios are often equal in ascitic fluid and plasma, sometimes even lower in the ascitic fluid. This emphasizes the ease with which globulins pass cell or other membrane barriers in these experiments. PMID:18143588

Fluid technology (selected components, devices, and systems): A compilation

NASA Technical Reports Server (NTRS)

1974-01-01

Developments in fluid technology and hydraulic equipment are presented. The subjects considered are: (1) the use of fluids in the operation of switches, amplifiers, and servo devices, (2) devices and data for laboratory use in the study of fluid dynamics, and (3) the use of fluids as controls and certain methods of controlling fluids.

[Neonatal facial palsy: identification of herpes simplex virus 1 in cerebrospinal fluid. Case report].

PubMed

Lubián López, Simón; Pérez Guerrero, Juan J; Salazar Oliva, Patricia; Benavente Fernández, Isabel

2018-06-01

Neonatal facial palsy is very uncommon and is generally diagnosed at birth. We present the first published case of neonatal facial palsy with identification of herpes simplex virus 1 in cerebrospinal fluid. A 35-day-old male was presented at the Emergency Department with mouth deviation to the left and impossibility of full closure of the right eye. There were no symptoms of infection or relevant medical history. Physical examination was compatible with peripheral facial palsy. Studies performed at admission were normal (blood count, biochemical analysis and coagulation blood tests and cerebrospinal fluid analysis). The patient was admitted on oral prednisolone and intravenous aciclovir. Cranial magnetic resonance was normal. Polymerase chain reaction test for herpes simplex virus 1 in cerebrospinal fluid was reported positive after 48 hours of admission. Patient followed good evolution and received prednisolone for 7 days and acyclovir for 21 days. At discharge, neurological examination was normal. Sociedad Argentina de Pediatría.

The Influence of AN Interacting Vacuum Energy on the Gravitational Collapse of a Star Fluid

NASA Astrophysics Data System (ADS)

Campos, M.

2014-02-01

To explain the accelerated expansion of the universe, models with interacting dark components has been considered in the literature. Generally, the dark energy component is physically interpreted as the vacuum energy. However, at the other side of the same coin, the influence of the vacuum energy in the gravitational collapse is a topic of scientific interest. Based in a simple assumption on the collapsed rate of the matter fluid density that is altered by the inclusion of a vacuum energy component that interacts with the matter fluid, we study the final fate of the collapse process.

Low pressure drop, multi-slit virtual impactor

DOEpatents

Bergman, Werner

2002-01-01

Fluid flow is directed into a multiplicity of slit nozzles positioned so that the fluid flow is directed into a gap between the nozzles and (a) a number of receiving chambers and (b) a number of exhaust chambers. The nozzles and chambers are select so that the fluid flow will be separated into a first particle flow component with larger and a second particle flow component with the smaller particles.

Mean flow generation mechanism by inertial waves and normal modes

NASA Astrophysics Data System (ADS)

Will, Andreas; Ghasemi, Abouzar

2016-04-01

The mean flow generation mechanism by nonlinearity of the inertial normal modes and inertial wave beams in a rotating annular cavity with longitudinally librating walls in stable regime is discussed. Inertial normal modes (standing waves) are excited when libration frequency matches eigenfrequencies of the system. Inertial wave beams are produced by Ekman pumping and suction in a rotating cylinder and form periodic orbits or periodic ray trajectories at selected frequencies. Inertial wave beams emerge as concentrated shear layers in a librating annular cavity, while normal modes appear as global recirculation cells. Both (inertial wave beam and mode) are helical and thus intrinsically non-linear flow structures. No second mode or wave is necessary for non-linearity. We considered the low order normal modes (1,1), (2,1) and (2,2) which are expected to be excited in the planetary objects and investigate the mean flow generation mechanism using two independent solutions: 1) analytical solution (Borcia 2012) and 2) the wave component of the flow (ω0 component) obtained from the direct numerical simulation (DNS). It is well known that a retrograde bulk mean flow is generated by the Ekman boundary layer and E1/4-Stewartson layer close to the outer cylinder side wall due to libration. At and around the normal mode resonant frequencies we found additionally a prograde azimuthal mean flow (Inertial Normal Mode Mean Flow: INMMF) in the bulk of the fluid. The fluid in the bulk is in geostrophic balance in the absence of the inertial normal modes. However, when INMMF is excited, we found that the geostrophic balance does not hold in the region occupied by INMMF. We hypothesize that INMMF is generated by the nonlinearity of the normal modes or by second order effects. Expanding the velocity {V}(u_r,u_θ,u_z) and pressure (p) in a power series in ɛ (libration amplitude), the Navier-Stokes equations are segregated into the linear and nonlinear parts at orders ɛ1 and ɛ^2, respectively. The former is used to find the analytical solution of the normal modes (Borcia 2012). Plugging two independent solutions into the latter we investigate the generation mechanism of INMMF. We found R1^1=overbar{partial_z(u_r1 u_z^1)}, R2^1=overbar{partial_r(u_r1 u_r^1)} as source terms responsible for the generation of INMMF. The helical structure of the inertial waves causes the nonlinear terms R1 and R2 to be nonzero, contributing to the generation of INMMF. We used u_ra and u_za obtained from the analytical solution (Borcia 2012) and computed the source terms R1a and R2a and found a structural correspondence with the corresponding field computed from the DNS solution for the three normal modes investigated. The sum of R11 and R21 exhibits a good structural correspondence with INMMF. Interestingly, INMMF magnitude depends on the inertial wave beams and normal modes. For instance we found that INMMF is generated more efficiently for the libration frequency ω=1.58, although the resonant frequency is predicted by the analytical solution to be at ω=1.576 (normal mode (2,1)). Separating the inertial wave beams from the flow field obtained by DNS, using the analytical normal mode solution, we explored the phase lag between inertial wave beams and normal mode. We inferred that the normal mode amplitude is high only if the phase lag between the inertial wave beam and the normal mode is predominantly positive. In this case a high amplitude INMMF amplitude can be found. This supports the hypothesis that the normal modes are generated by the inertial wave beam in analogy to resonant forcing in classical mechanics. Interestingly, the 'optimum' phase lag found is much smaller than π/2. {Acknowledgement:} This work is a part of the project "Mischung und Grundstromanregung durch propagierende Trgheitswellen: Theorie, Experiment und Simulation" supported by the German Science Foundation (DFG). We would like to thank M. Klein, U. Harlander, I. Borcia and E. Schaller for helpful discussions and invaluable contributions. {References:} Borcia, I. D. & Harlander, U. 2012 Inertial waves in a rotating annulus with inclined inner cylinder: comparing the spectrum of wave attractor frequency bands and the eigenspectrum in the limit of zero inclination. Theor. Comput. Fluid Dyn. 27, 397-413.

Slip behaviour of experimental faults subjected to fluid pressure stimulation: carbonates vs. shales

NASA Astrophysics Data System (ADS)

Collettini, C.; Scuderi, M. M.; Marone, C.

2017-12-01

Fluid overpressure is one of the primary mechanisms for triggering tectonic fault slip and human-induced seismicity. This mechanism has been invoked to explain the dramatic increase in seismicity associated with waste water disposal in intra-plate setting, and it is appealing because fluids lubricate the fault and reduce the effective normal stress that holds the fault in place. Although, this basic physical mechanism is well understood, several fundamental questions remain including the apparent delay between fluid injection and seismicity, the role of fault zone rheology, and the relationship between injection volume and earthquake size. Moreover, models of earthquake nucleation predict that a reduction in normal stress, as expected for fluid overpressure, should stabilize fault slip. Here, we address these questions using laboratory experiments, conducted in the double direct shear configuration in a true-triaxial machine on carbonates and shale fault gouges. In particular, we: 1) evaluate frictional strength and permeability, 2) characterize the rate- and state- friction parameters and 3) study fault slip evolution during fluid pressure stimulations. With increasing fluid pressure, when shear and effective normal stresses reach the failure condition, in calcite gouges, characterized by slightly velocity strengthening behaviour, we observe an acceleration of slip that spontaneously evolves into dynamic failure. For shale gouges, with a strong rate-strengthening behaviour, we document complex fault slip behavior characterized by periodic accelerations and decelerations with slip velocity that remains slow (i.e. v 200 µm/s), never approaching dynamic slip rates. Our data indicate that fault rheology and fault stability is controlled by the coupling between fluid pressure and rate- and state- friction parameters suggesting that their comprehensive characterization is fundamental for assessing the role of fluid pressure in natural and human induced earthquakes.

Temporary divergence paralysis in viral meningitis.

PubMed

Bakker, Stef L M; Gan, Ivan M

2008-06-01

A 43-year-old woman who reported diplopia and headache was found to have comitant esotropia at distance fixation and normal alignment at reading distance (divergence paralysis). Eye movement, including abduction, was normal as was the rest of the neurologic examination. Brain MRI was normal. Lumbar puncture showed an elevated opening pressure and a cerebrospinal fluid formula consistent with viral meningitis. The patient was treated with intravenous fluids and analgesics and with a temporary prism to alleviate diplopia. Within 3 weeks, she had fully recovered. This is the first report of divergence palsy in viral meningitis.

Reversible grasp reflexes in normal pressure hydrocephalus.

PubMed

Thomas, Rhys H; Bennetto, Luke; Silva, Mark T

2009-05-01

We present two cases of normal pressure hydrocephalus in combination with grasp reflexes. In both cases the grasp reflexes disappeared following high volume cerebrospinal fluid removal. In one of the cases the grasp reflexes returned over a period of weeks but again resolved following definitive cerebrospinal fluid shunting surgery, and remained absent until final follow up at 9 months. We hypothesise that resolving grasp reflexes following high volume CSF removal has both diagnostic and prognostic value in normal pressure hydrocephalus, encouraging larger studies on the relevance of primitive reflexes in NPH.

Nuclear reactor insulation and preheat system

DOEpatents

Wampole, Nevin C.

1978-01-01

An insulation and preheat system for preselected components of a fluid cooled nuclear reactor. A gas tight barrier or compartment of thermal insulation surrounds the selected components and includes devices to heat the internal atmosphere of the compartment. An external surface of the compartment or enclosure is cooled, such as by a circulating fluid. The heating devices provide for preheating of the components, as well as maintenance of a temperature sufficient to ensure that the reactor coolant fluid will not solidify during shutdown. The external cooling limits the heat transferred to other plant structures, such as supporting concrete and steel. The barrier is spaced far enough from the surrounded components so as to allow access for remote or manual inspection, maintenance, and repair.

Molding apparatus. [for thermosetting plastic compositions

NASA Technical Reports Server (NTRS)

Heier, W. C. (Inventor)

1974-01-01

Apparatus for compression molding of thermosetting plastics compositions including interfitting hollow male and female components is reported. The components are adapted to be compressed to form a rocket nozzle in a cavity. A thermal jacket is provided exteriorly adjacent to the female component for circulating a thermal transfer fluid to effect curing of a thermosetting plastics material being molded. Each of the male and female components is provided with suitable inlets and outlets for circulating a thermal transfer fluid.

Poromechanics of stick-slip frictional sliding and strength recovery on tectonic faults

DOE PAGES

Scuderi, Marco M.; Carpenter, Brett M.; Johnson, Paul A.; ...

2015-10-22

Pore fluids influence many aspects of tectonic faulting including frictional strength aseismic creep and effective stress during the seismic cycle. But, the role of pore fluid pressure during earthquake nucleation and dynamic rupture remains poorly understood. Here we report on the evolution of pore fluid pressure and porosity during laboratory stick-slip events as an analog for the seismic cycle. We sheared layers of simulated fault gouge consisting of glass beads in a double-direct shear configuration under true triaxial stresses using drained and undrained fluid conditions and effective normal stress of 5–10 MPa. Shear stress was applied via a constant displacementmore » rate, which we varied in velocity step tests from 0.1 to 30 µm/s. Here, we observe net pore pressure increases, or compaction, during dynamic failure and pore pressure decreases, or dilation, during the interseismic period, depending on fluid boundary conditions. In some cases, a brief period of dilation is attendant with the onset of dynamic stick slip. Our data show that time-dependent strengthening and dynamic stress drop increase with effective normal stress and vary with fluid conditions. For undrained conditions, dilation and preseismic slip are directly related to pore fluid depressurization; they increase with effective normal stress and recurrence time. Microstructural observations confirm the role of water-activated contact growth and shear-driven elastoplastic processes at grain junctions. These results indicate that physicochemical processes acting at grain junctions together with fluid pressure changes dictate stick-slip stress drop and interseismic creep rates and thus play a key role in earthquake nucleation and rupture propagation.« less

The aortic reservoir-wave as a paradigm for arterial haemodynamics: insights from three-dimensional fluid-structure interaction simulations in a model of aortic coarctation.

PubMed

Segers, Patrick; Taelman, Liesbeth; Degroote, Joris; Bols, Joris; Vierendeels, Jan

2015-03-01

The reservoir-wave paradigm considers aortic pressure as the superposition of a 'reservoir pressure', directly related to changes in reservoir volume, and an 'excess' component ascribed to wave dynamics. The change in reservoir pressure is assumed to be proportional to the difference between aortic inflow and outflow (i.e. aortic volume changes), an assumption that is virtually impossible to validate in vivo. The aim of this study is therefore to apply the reservoir-wave paradigm to aortic pressure and flow waves obtained from three-dimensional fluid-structure interaction simulations in a model of a normal aorta, aortic coarctation (narrowed descending aorta) and stented coarctation (stiff segment in descending aorta). We found no unequivocal relation between the intraaortic volume and the reservoir pressure for any of the simulated cases. When plotted in a pressure-volume diagram, hysteresis loops are found that are looped in a clockwise way indicating that the reservoir pressure is lower than the pressure associated with the change in volume. The reservoir-wave analysis leads to very high excess pressures, especially for the coarctation models, but to surprisingly little changes of the reservoir component despite the impediment of the buffer capacity of the aorta. With the observation that reservoir pressure is not related to the volume in the aortic reservoir in systole, an intrinsic assumption in the wave-reservoir concept is invalidated and, consequently, also the assumption that the excess pressure is the component of pressure that can be attributed to wave travel and reflection.

The influence of the acetabular labrum seal, intact articular superficial zone and synovial fluid thixotropy on squeeze-film lubrication of a spherical synovial joint.

PubMed

Hlavácek, M

2002-10-01

A model of synovial fluid (SF) filtration by articular cartilage (AC) in a step-loaded spherical synovial joint at rest is presented. The effects of joint pathology (such as a depleted acetabular labrum, a depleted cartilage superficial zone consistent with early osteoarthritis and an inflammatory SF) on the squeezed synovial film are also investigated. Biphasic mixture models for AC (ideal fluid and elastic porous transversely isotropic two-layer matrix) and for SF (ideal and thixotropic fluids) are applied and the following results are obtained. If the acetabular labrum is able to seal the pressurised SF between the articular surfaces (as in the normal hip joint), the fluid in the synovial film and in the cartilage within the labral ring is homogeneously pressurised. The articular surfaces remain separated by a fluid film for minutes. If the labrum is destroyed or absent and the SF can escape across the contact edge, the fluid pressure is non-homogeneous and with a small jump at the articular surface at the very moment of load application. The ensuing synovial film filtration by porous cartilage is lower for the normal cartilage (with the intact superficial zone) than if this zone is already depleted or rubbed off as in the early stage of primary osteoarthritis. Compared with the inflammatory (Newtonian) SF, the normal (thixotropic) fluid applies favourably in the squeezed film near the contact centre only, yielding a thicker SF film there, but not affecting the minimum thickness in the fluid film profile at a fixed time. For all that, in the unsealed case for both the normal and pathological joint, the macromolecular concentration of the hyaluronic acid-protein complex in the synovial film quickly increases due to the filtration in the greater part of the contact. A stable synovial gel film, thick on the order of 10(-7)m, protecting the articular surfaces from the intimate contact, is formed within a couple of seconds. Boundary lubrication by the synovial gel is established if sliding motion follows until a fresh SF is entrained into the contact. This theoretical prediction is open for experimental verifications.

A randomized, double-blinded, controlled trial of the effects of fluid rate and/or presence of dextrose in intravenous fluids on the labor course of nulliparas.

PubMed

Fong, Alex; Serra, Allison E; Caballero, Deysi; Garite, Thomas J; Shrivastava, Vineet K

2017-08-01

Prolonged labor has been demonstrated to increase adverse maternal and neonatal outcome. A practice that may decrease the risk of prolonged labor is the modification of fluid intake during labor. Several studies demonstrated that increased hydration in labor as well as addition of dextrose-containing fluids may be associated with a decrease in length of labor. The purpose of our study was to characterize whether high-dose intravenous fluids, standard-dose fluids with dextrose, or high-dose fluids with dextrose show a difference in the duration of labor in nulliparas. Nulliparous subjects with singletons who presented in active labor were randomized to 1 of 3 groups of intravenous fluids: 250 mL/h of normal saline, 125 mL/h of 5% dextrose in normal saline, or 250 mL/h of 2.5% dextrose in normal saline. The primary outcome was total length of labor from initiation of intravenous fluid in vaginally delivered subjects. Secondary outcomes included cesarean delivery rate and length of second stage of labor, among other maternal and neonatal outcomes. In all, 274 subjects who met inclusion criteria were enrolled. There were no differences in baseline characteristics among the 3 groups. There was no difference in the primary outcome of total length of labor in vaginally delivered subjects among the 3 groups. First stage of labor duration, second stage of labor duration, and cesarean delivery rates were also equivalent. There were no differences identified in other secondary outcomes including clinical chorioamnionitis, postpartum hemorrhage, blood loss, Apgar scores, or neonatal intensive care admission. There is no difference in length of labor or delivery outcomes when comparing high-dose intravenous fluids, addition of dextrose, or use of high-dose intravenous fluids with dextrose in nulliparous women who present in active labor. Copyright © 2017 Elsevier Inc. All rights reserved.

Hyperacid volcano-hydrothermal fluids from Copahue volcano, Argentina: Analogs for "subduction zone fluids"?

NASA Astrophysics Data System (ADS)

Varekamp, J. C.

2007-12-01

Hyperacid concentrated Chlorine-Sulfate brines occur in many young arc volcanoes, with pH values <1, high concentrations of volcanogenic elements (S, Cl, F, As, B) and the main rock forming elements (Ca, Al, Mg, K, Na, P). Sulfur isotope data and Silica thermometry from such fluids sampled over a ten year period from the Copahue volcanic system (Argentina) suggest reservoir temperatures of 175-300 oC, whereas the surface fluids do not exceed local boiling temperatures. These fluids are generated at much lower P-T conditions than fluids associated with a dehydrating subducted sediment complex below arc volcanoes, but their fundamental chemical compositions may have similarities. Incompatible trace element, major element concentrations and Pb isotope compositions of the fluids were used to determine the most likely rock protoliths for these fluids. Mean rock- normalized trace element diagrams then indicate which elements are quantitatively extracted from the rocks and which are left behind or precipitated in secondary phases. Most LILE show flat rock-normalized patterns, indicating close to congruent dissolution, whereas Ta-Nb-Ti show strong depletions in the rock-normalized diagrams. These HFSE are either left behind in the altered rock protolith or were precipitated along the way up. The behavior of U and Th is almost identical, suggesting that in these low pH fluids with abundant ligands Th is just as easily transported as U, which is not the case in more dilute, neutral fluids. Most analyzed fluids have steeper LREE patterns than the rocks and have negative Eu anomalies similar to the rocks. Fluids that interacted with newly intruded magma e.g., during the 2000 eruption, have much less pronounced Eu anomalies, which was most likely caused by the preferential dissolution of plagioclase when newly intruded magma interacted with the acid fluids. The fluids show a strong positive correlation between Y and Cd (similar to MORB basalts, Yi et al., JGR, 2000), suggesting that Cd is mainly a rock-derived element that may not show chalcophilic behavior. The fluids are strongly enriched (relative to rock) in As, Zn and Pb, suggesting that these elements were carried with the volcanic gas phase into the system. In summary, if these fluids are broadly similar to fluids from dehydrating subducted sediments, they tend to transport preferently the LILE, LREE, U as well as Th, while the HFSE are left behind.

Cerebral spinal fluid (CSF) collection

MedlinePlus

... establish the diagnosis of normal pressure hydrocephalus. Normal Results Normal values typically range as follows: Pressure: 70 ... measurements or may test different specimens. What Abnormal Results Mean If the CSF looks cloudy, it could ...

Spectrometer for measuring the concentration of components in a fluid stream and method for using same

DOEpatents

Durham, Michael D.; Stedman, Donald H.; Ebner, Timothy G.; Burkhardt, Mark R.

1991-01-01

A device and method for measuring the concentrations of components of a fluid stream. Preferably, the fluid stream is an in situ gas stream, such as a fossil fuel fired flue gas in a smoke stack. The measurements are determined from the intensity of radiation over a selected range of radiation wavelengths using peak-to-trough calculations. The need for a reference intensity is eliminated.

Separator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ashbrook, C.L.

1970-09-22

A separator consists of a housing having an upper fluid inlet and a lower fluid outlet in the sides of the housing. An inverted conical tube is disposed internally of the housing and is in fluid communication with the fluid inlet. The upper fluid inlet tangentially intersects the inverted conical tube so as to create a rotating vortex upon introduction of the mixture. Axially disposed within the vortex tube at the upper end is a withdrawal tube for removing lighter mixture components that are drawn toward the center of the tube. At the lower end of the vortex tube ismore » an adjustable impact plate for transmitting a concussion wave through the vortexed body, so as to cause cavitation. Heavier mixture components gravitate toward the lower fluid outlet and are withdrawn through it. (7 claims)« less

Oxygen supersaturated fluid using fine micro/nanobubbles

PubMed Central

Matsuki, Noriaki; Ishikawa, Takuji; Ichiba, Shingo; Shiba, Naoki; Ujike, Yoshihito; Yamaguchi, Takami

2014-01-01

Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies. PMID:25285003

Oxygen supersaturated fluid using fine micro/nanobubbles.

PubMed

Matsuki, Noriaki; Ishikawa, Takuji; Ichiba, Shingo; Shiba, Naoki; Ujike, Yoshihito; Yamaguchi, Takami

2014-01-01

Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.

[Water-exchange processes in hyaline cartilage and its basic components in a normal state and in osteoarthritis].

PubMed

Nikolaeva, S S; Chkhol, K Z; Bykov, V A; Roshchina, A A; Iakovleva, L V; Koroleva, O A; Omel'ianenko, N P; Rebrov, L B

2000-01-01

The content of different forms of tissue water was studied in the normal articular cartilage and osteoarthrosis cartilage and its structural components: collagen, potassium hyaluronate, sodium chondroitinsulphate and its complexes. In the components of cartilage matrix a few of fractions of bound water different in the strength of binding are present. At the maximal humidity, all water in collagen binds with the active groups of biopolymers and in the glycosaminoglycans, in addition to bound water, are present, two crystal forms of freezing water (free water) at least. The quantity of free water in the collagen-chondroitin sulphat membrane, is increased with the increase of chondroitin sulphate. In the collagen-hyaluronate complex, fraction of free water is found only at the low concentration of hyaluronate kalium. It was shown that in the hyalin cartilage, in different from the other connective tissue (skin, achilles tendon), the most part of water is free water and its quantity is increased in the osteoarthrosis. It is supposed that the rearrangement of binding and free-water fractions in the osteoarthrosis is the result of deficiency of hyaluronic acid and therefore this may be regarded in the improvement of methods of treatment. This scientific and methodical approach allow to receive information on the forms and binding energy of water in the biological tissues, which is absorbed from fluids and steam phase and determine characters of the pathological changes.

Plasma response measurements of non-axisymmetric magnetic perturbations on DIII-D via soft x-ray imaging

DOE PAGES

Shafer, Morgan W.; Unterberg, Ezekial A.; Wingen, Andreas; ...

2014-12-29

Recent observations on DIII-D have advanced the understanding of plasma response to applied resonant magnetic perturbations (RMPs) in both H-mode and L-mode plasmas. Three distinct 3D features localized in minor radius are imaged via filtered soft x-ray emission: (i) the formation of lobes extending from the unperturbed separatrix in the X-point region at the plasma boundary, (ii) helical kink-like perturbations in the steep-gradient region inside the separatrix, and (iii) amplified islands in the core of a low-rotation L-mode plasma. In this study, these measurements are used to test and to validate plasma response models, which are crucial for providing predictivemore » capability of edge-localized mode control. In particular, vacuum and two-fluid resistive magnetohydrodynamic(MHD) responses are tested in the regions of these measurements. At the plasma boundary in H-mode discharges with n = 3 RMPs applied, measurements compare well to vacuum-field calculations that predict lobe structures. Yet in the steep-gradient region, measurements agree better with calculations from the linear resistive two-fluid MHD code, M3D-C1. Relative to the vacuum fields, the resistive two-fluid MHD calculations show a reduction in the pitch-resonant components of the normal magnetic field (screening), and amplification of non-resonant components associated with ideal kink modes. However, the calculations still over-predict the amplitude of the measuredperturbation by a factor of 4. In a slowly rotating L-mode plasma with n = 1 RMPs, core islands are observed amplified from vacuum predictions. Finally, these results indicate that while the vacuum approach describes measurements in the edge region well, it is important to include effects of extended MHD in the pedestal and deeper in the plasma core.« less

Plasma Sail Concept Fundamentals

NASA Technical Reports Server (NTRS)

Khazanov, G. V.; Delamere, P.; Kabin, K.; Linde, T. J.

2004-01-01

The mini-magnetospheric plasma propulsion (M2P2) device, originally proposed by Winglee et al., predicts that a 15-km standoff distance (or 20-km cross-sectional dimension) of the magnetic bubble will provide for sufficient momentum transfer from the solar wind to accelerate a spacecraft to unprecedented speeds of 50 C80 km/s after an acceleration period of 3 mo. Such velocities will enable travel out of the solar system in period of 7 yr almost an order of magnitude improvement over present chemical-based propulsion systems. However, for the parameters of the simulation of Winglee et al., a fluid model for the interaction of M2P2 with the solar wind is not valid. It is assumed in the magnetohydrodynamic (MHD) fluid model, normally applied to planetary magnetospheres, that the characteristic scale size is much greater than the Larmor radius and ion skin depth of the solar wind. In the case of M2P2, the size of the magnetic bubble is actually less than or comparable to the scale of these characteristic parameters. Therefore, a kinetic approach, which addresses the small-scale physical mechanisms, must be used. A two-component approach to determining a preliminary estimate of the momentum transfer to the plasma sail has been adopted. The first component is a self-consistent MHD simulation of the small-scale expansion phase of the magnetic bubble. The fluid treatment is valid to roughly 5 km from the source and the steady-state MHD solution at the 5 km boundary was then used as initial conditions for the hybrid simulation. The hybrid simulations showed that the forces delivered to the innermost regions of the plasma sail are considerably ( 10 times) smaller than the MHD counterpart, are dominated by the magnetic field pressure gradient, and are directed primarily in the transverse direction.

[Research of the essential oil of Plumeria rubra var. actifolia from Laos by supercritical carbon dioxide extraction].

PubMed

Xiao, Xin-Yu; Cui, Long-Hai; Zhou, Xin-Xin; Wu, Yan; Ge, Fa-Huan

2011-05-01

The orthogonal test and the supercritical carbon dioxide fluid extraction were used for optimizing the extraction of the essential oil from Plumeria rubra var. actifolia for the first time. Compared with the steam distillation, the optimal operation parameter of extraction was as follows: extraction pressure 25 MPa, extraction temperature 45 degrees C; separator I pressure 12 MPa, separator I temperature 55 degrees C; separator II pressure 6 MPa, separator II temperature 30 degrees C. Under this condition the yield of the essential oil was 5.8927%. The components were separated and identified by GC-MS. 53 components of Plumeria rubra var. actifolia measured by SFE method were identified and determined by normalization method. The main components were 1, 6, 10-dodecatrien-3-ol, 3, 7, 11-trimethyl, benzoic acid, 2-hydroxy-, phenylmethyl ester, 1, 2-benzenedicarboxylic acid, bis(2-methylpropyl) ester,etc.. 1, 2-Benzenedicarboxylic acid, bis (2-methylpropyl) este. took up 66.11% of the total amount, and there was much difference of the results from SD method.

Simulation study of the carbon dioxide enhanced oil recovery pilot test in the Griffithsville Field, Lincoln County, West Virginia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brummert, A.C.

1990-09-01

A carbon dioxide pilot test was conducted in the Griffithsville Field, Lincoln County, West Virginia, on a 90-acre tract containing nine 10-acre, normal, five-spot patterns arranged in a 3 {times} 3 matrix. This post-flood simulation study evaluates the initial pressure buildup phase of water injection, the carbon dioxide injection phase, and the chase water injection phase. Core data, geophysical well logs, fluid property data, well test data, and injection/production histories were used in setting up the data input record for the reservoir simulator. The reservoir simulator was IMEX, a four-component, black-oil reservoir simulator. 23 refs., 15 figs., 3 tabs.

Fluid dynamics vascular theory of brain and inner-ear function in traumatic brain injury: a translational hypothesis for diagnosis and treatment.

PubMed

Shulman, Abraham; Strashun, Arnold M

2009-01-01

It is hypothesized that in all traumatic brain injury (TBI) patients with a clinical history of closed or penetrating head injury, the initial head trauma is associated with a vibratory sensation and noise exposure, with resultant alteration in vascular supply to the structures and contents of the fluid compartments of brain and ear (i.e., the fluid dynamics vascular theory of brain-inner-ear function [FDVTBE]). The primary etiology-head trauma-results in an initial fluctuation, interference, or interaction in the normal fluid dynamics between brain and labyrinth of the inner ear, with a resultant clinical diversity of complaints varying in time of onset and severity. Normal function of the brain and ear is a reflection of a normal state of homeostasis between the fluid compartments in the brain of cerebrospinal fluid and perilymph-endolymph in the labyrinth of the ear. The normal homeostasis in the structures and contents between the two fluid compartment systems--intracerebral and intralabyrinthine--is controlled by mechanisms involved in the maintenance of normal pressures, water and electrolyte content, and neurotransmitter activities. The initial pathophysiology (a reflection of an alteration in the vascular supply to the brain-ear) is hypothesized to be an initial acute inflammatory response, persistence of which results in ischemia and an irreversible alteration in the involved neural substrates of brain-ear. Clinically, a chronic multisymptom complex becomes manifest. The multisymptom complex, individual for each TBI patient regardless of the diagnostic TBI category (i.e., mild, moderate, or severe), initially reflects processes of inflammation and ischemia which, in brain, result in brain volume loss identified as neurodegeneration and hydrocephalus ex vacuo or an alteration in cerebrospinal fluid production (i.e., pseudotumor cerebri) and, in ear, secondary endolymphatic hydrops with associated cochleovestibular complaints of hearing loss, tinnitus, vertigo, ear blockage, and hyperacusis. The FDVTBE integrates and translates a neurovascular hypothesis for Alzheimer's disease to TBI. This study presents an FDVTBE hypothesis of TBI to explain the clinical association of head trauma (TBI) and central nervous system neurodegeneration with multisensory complaints, highlighted by and focusing on cochleovestibular complaints. A clinical case report, previously published for demonstration of the cerebrovascular medical significance of a particular type of tinnitus, and evidence-based basic science and clinical medicine are cited to provide objective evidence in support and demonstration of the FDVTBE.

Examination of body fluids.

PubMed

Feldman, B F; Ruehl, W W

1984-04-01

In dogs, the pericardial sac contains about 0.3 ml, and the pleural and peritoneal cavities 0-15 ml of clear, straw-colored fluid of pH 7.4, specific gravity 1.016, protein content less than 3.0 g/dl and cell count less than 3000/microliter. Fat can be cleared from chylous fluid with NaOH and ether. Inflammation is indicated by a cell count greater than 3000/microliter. Amylase levels in peritoneal fluid are elevated in necrotizing pancreatitis. The percentage of polymorphonuclear WBC exceeds 50% in bacterial inflammations. Normal joints contain less than 1 ml highly viscid, clear or straw-colored synovial fluid with less than 1000 nucleated cells/microliter. Synovial fluid becomes flocculent and less viscid in septic and occasionally in immune-mediated arthritis, often with cell counts greater than 75,000/microliter, with 75-90% polymorphonuclear WBC. Cerebrospinal fluid is normally acellular, clear and colorless but may be red, yellow or brown with intracranial hematomas. Viral or aseptic meningitis is characterized by mononuclear cell counts of less than 500/microliter. In acute bacterial meningitis, nucleated cell counts are greater than 1000/microliter, with most being polymorphonuclear WBC. Gram staining of cerebrospinal fluid is not useful.

New mud system produces solids-free, reusable water

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-02-01

The Corpus Christi, Texas, based Cameron Equipment Co., Inc., has developed a closed-loop mud treating system that removes solids from water-based systems and leaves the separated fluid clean and chemical free enough to be re-used directly on the rig. The system has been successfully applied by a Gulf of Mexico operator in areas where zero discharge is required. The alternative mud conditions program offered by the developers is called the Cameron Fluid Recycling System. Designed for closed-loop water-based fluids, the system is a new method of removing solids from normally discharged fluids such as drilling mud, waste and wash water,more » or any other water-based fluid that contains undesirable solids. The patented method efficiently produces end products that are (1) dry solids; and (2) essentially 100% solids-free fluid that can be re-used in the same mud system. All excess drilling mud, and all wash water that would normally go to the reserve pit or a cuttings barge are collected in a tank. Recycled fluid is compatible with the mud system fluid, no harmful chemicals are used, and pH is not altered.« less

Statistical mechanics of homogeneous partly pinned fluid systems.

PubMed

Krakoviack, Vincent

2010-12-01

The homogeneous partly pinned fluid systems are simple models of a fluid confined in a disordered porous matrix obtained by arresting randomly chosen particles in a one-component bulk fluid or one of the two components of a binary mixture. In this paper, their configurational properties are investigated. It is shown that a peculiar complementarity exists between the mobile and immobile phases, which originates from the fact that the solid is prepared in presence of and in equilibrium with the adsorbed fluid. Simple identities follow, which connect different types of configurational averages, either relative to the fluid-matrix system or to the bulk fluid from which it is prepared. Crucial simplifications result for the computation of important structural quantities, both in computer simulations and in theoretical approaches. Finally, possible applications of the model in the field of dynamics in confinement or in strongly asymmetric mixtures are suggested.

14 CFR 23.1099 - Carburetor deicing fluid system detail design.

Code of Federal Regulations, 2012 CFR

2012-01-01

... fluid system must meet the applicable requirements for the design of a fuel system, except as specified... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Carburetor deicing fluid system detail... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES...

14 CFR 23.1099 - Carburetor deicing fluid system detail design.

Code of Federal Regulations, 2010 CFR

2010-01-01

... fluid system must meet the applicable requirements for the design of a fuel system, except as specified... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Carburetor deicing fluid system detail... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES...

14 CFR 23.1099 - Carburetor deicing fluid system detail design.

Code of Federal Regulations, 2013 CFR

2013-01-01

... fluid system must meet the applicable requirements for the design of a fuel system, except as specified... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Carburetor deicing fluid system detail... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES...

14 CFR 23.1099 - Carburetor deicing fluid system detail design.

Code of Federal Regulations, 2011 CFR

2011-01-01

... fluid system must meet the applicable requirements for the design of a fuel system, except as specified... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Carburetor deicing fluid system detail... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES...

14 CFR 23.1099 - Carburetor deicing fluid system detail design.

Code of Federal Regulations, 2014 CFR

2014-01-01

... fluid system must meet the applicable requirements for the design of a fuel system, except as specified... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Carburetor deicing fluid system detail... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES...

Estimation of gestational age from study of amniotic fluid and clinical assessment.

PubMed Central

Deshpande, T. V.; Harding, P. G.; Jaco, N. T.

1977-01-01

Study of 108 samples of amniotic fluid obtained between 28 and 42 weeks' gestation from 101 patients revealed that in normal pregnancies the creatinine concentration, lecithin/sphingomyelin (L/S) ratio and percentage of fat cells correlated better with the gestational age of the newborn--assessed by clinical criteria--than did the bilirubin and sodium concentrations. A creatinine concentration of 1.75 mg/dL or more, an L/S ratio of 4 or more and a fat cell percentage of 10 or more correlated significantly with a gestational age of 37 weeks or more. In abnormal pregnancies (those with obstetric or medical complications, or both) the mean creatinine concentration in the amniotic fluid was significantly less than expected for gestational age in fetal dysmaturity and greater than expected when the mother had diabetes. The mean L/S ratio in the amniotic fluid was elevated when the mother had hypertension or smoked and in cases of fetal dysmaturity or long interval between rupture of the membranes and delivery, whereas it was significantly lower than normal when the mother had diabetes. The mean bilirubin concentration in the amniotic fluid was significantly lower than normal when the mother had hypertension. When the mother had diabetes, maturity of the fetal lung, liver, skin and brain appeared to be delayed, according to the values for the amniotic fluid constituents. PMID:912615

Associations of semen quality with non-essential heavy metals in blood and seminal fluid: data from the Environment and Male Infertility (EMI) study in Lebanon.

PubMed

Sukhn, Carol; Awwad, Johnny; Ghantous, Akram; Zaatari, Ghazi

2018-06-21

Human exposure to environmental pollutants is widespread. It was suggested that exposure to non-essential heavy metals may adversely affect semen development in men. To evaluate associations between non-essential heavy metals in blood and seminal fluid and semen quality parameters in men. Male partners of heterosexual couples were included. The following elements were measured in blood and seminal fluid: lead (Pb), cadmium (Cd), arsenic (As), barium (Ba), mercury (Hg), and uranium (U) using ion-coupled plasma-mass spectrometry. The fertility clinic at the American University of Beirut Medical Center. Semen quality parameters (volume, concentration, total count, progressive motility, viability, and normal morphology). We found that participants with low-quality semen had significantly higher Cd and Ba concentrations in the seminal fluid than participants with normal-quality semen. We also observed significant associations between low sperm viability and higher blood Cd and Ba, as well as higher seminal Pb, Cd, Ba, and U. Furthermore, U concentrations in the seminal fluid were associated with increased odds ratios for below-reference progressive sperm motility and normal morphology. Environmental exposures to Pb, Cd, Ba, and U appear to adversely influence sperm development in men. In non-occupationally exposed men, measurements of heavy metals in the seminal fluid may be more predictive of below-reference sperm quality parameters than in blood.

Development of an Aeroelastic Modeling Capability for Transient Nozzle Side Load Analysis

NASA Technical Reports Server (NTRS)

Wang, Ten-See; Zhao, Xiang; Zhang, Sijun; Chen, Yen-Sen

2013-01-01

Lateral nozzle forces are known to cause severe structural damage to any new rocket engine in development during test. While three-dimensional, transient, turbulent, chemically reacting computational fluid dynamics methodology has been demonstrated to capture major side load physics with rigid nozzles, hot-fire tests often show nozzle structure deformation during major side load events, leading to structural damages if structural strengthening measures were not taken. The modeling picture is incomplete without the capability to address the two-way responses between the structure and fluid. The objective of this study is to develop a coupled aeroelastic modeling capability by implementing the necessary structural dynamics component into an anchored computational fluid dynamics methodology. The computational fluid dynamics component is based on an unstructured-grid, pressure-based computational fluid dynamics formulation, while the computational structural dynamics component is developed in the framework of modal analysis. Transient aeroelastic nozzle startup analyses of the Block I Space Shuttle Main Engine at sea level were performed. The computed results from the aeroelastic nozzle modeling are presented.

Anomalous hydrodynamics and normal fluids in rapidly rotating Bose-Einstein condensates.

PubMed

Bourne, A; Wilkin, N K; Gunn, J M F

2006-06-23

In rapidly rotating condensed Bose systems we show that there is a regime of anomalous hydrodynamics which coincides with the mean field quantum Hall regime. A consequence is the absence of a normal fluid in any conventional sense. However, even the superfluid hydrodynamics is not described by conventional Bernoulli and continuity equations. We show that there are constraints which connect spatial variations of density and phase and that the vortex positions are not the simplest description of the dynamics. We demonstrate, inter alia, a simple relation between vortices and surface waves. We show that the surface waves can emulate a "normal fluid," allowing dissipation by energy and angular momentum absorbtion from vortex motion in the trap. The time scale is sensitive to the initial configuration, which can lead to long-lived vortex patches--perhaps related to those observed at JILA.

A Systems Biology Approach to Synovial Joint Lubrication in Health, Injury, and Disease

PubMed Central

Hui, Alexander Y.; McCarty, William J.; Masuda, Koichi; Firestein, Gary S.; Sah, Robert L.

2013-01-01

The synovial joint contains synovial fluid (SF) within a cavity bounded by articular cartilage and synovium. SF is a viscous fluid that has lubrication, metabolic, and regulatory functions within synovial joints. SF contains lubricant molecules, including proteoglycan-4 and hyaluronan. SF is an ultrafiltrate of plasma with secreted contributions from cell populations lining and within the synovial joint space, including chondrocytes and synoviocytes. Maintenance of normal SF lubricant composition and function are important for joint homeostasis. In osteoarthritis, rheumatoid arthritis, and joint injury, changes in lubricant composition and function accompany alterations in the cytokine and growth factor environment and increased fluid and molecular transport through joint tissues. Thus, understanding the synovial joint lubrication system requires a multi-faceted study of the various parts of the synovial joint and their interactions. Systems biology approaches at multiple scales are being used to describe the molecular, cellular, and tissue components and their interactions that comprise the functioning synovial joint. Analyses of the transcriptome and proteome of SF, cartilage, and synovium suggest that particular molecules and pathways play important roles in joint homeostasis and disease. Such information may be integrated with physicochemical tissue descriptions to construct integrative models of the synovial joint that ultimately may explain maintenance of health, recovery from injury, or development and progression of arthritis. PMID:21826801

Visualization of Computational Fluid Dynamics

NASA Technical Reports Server (NTRS)

Gerald-Yamasaki, Michael; Hultquist, Jeff; Bryson, Steve; Kenwright, David; Lane, David; Walatka, Pamela; Clucas, Jean; Watson, Velvin; Lasinski, T. A. (Technical Monitor)

1995-01-01

Scientific visualization serves the dual purpose of exploration and exposition of the results of numerical simulations of fluid flow. Along with the basic visualization process which transforms source data into images, there are four additional components to a complete visualization system: Source Data Processing, User Interface and Control, Presentation, and Information Management. The requirements imposed by the desired mode of operation (i.e. real-time, interactive, or batch) and the source data have their effect on each of these visualization system components. The special requirements imposed by the wide variety and size of the source data provided by the numerical simulation of fluid flow presents an enormous challenge to the visualization system designer. We describe the visualization system components including specific visualization techniques and how the mode of operation and source data requirements effect the construction of computational fluid dynamics visualization systems.

Spectrometer for measuring the concentration of components in a fluid stream and method for using same

DOEpatents

Durham, M.D.; Stedman, D.H.; Ebner, T.G.; Burkhardt, M.R.

1991-12-03

A device and method are described for measuring the concentrations of components of a fluid stream. Preferably, the fluid stream is an in-situ gas stream, such as a fossil fuel fired flue gas in a smoke stack. The measurements are determined from the intensity of radiation over a selected range of radiation wavelengths using peak-to-trough calculations. The need for a reference intensity is eliminated. 15 figures.

Ultraviolet light-responsive photorheological fluids: as a new class of smart fluids

NASA Astrophysics Data System (ADS)

Cho, Min-Young; Kim, Ji-Sik; Choi, Hyoung Jin; Choi, Seung-Bok; Kim, Gi-Woo

2017-05-01

We present a comprehensive introduction to the photorheological (PR) fluids whose rheological behavior can be changed by ultraviolet (UV) light with a wavelength of 365 nm. When the PR fluid was exposed to UV light, the viscosity of the fluid decreased, while the viscosity recovered to its initial value when UV light was turned off, indicating that the viscosity of these types of fluids can be reversible and tunable by UV light. Contrary to conventional smart fluids, such as electrorheological and magnetorheological fluids, PR fluid does not suffer from a phase splitting problem because it exists in a single-phase solution. Additionally, the PR fluid does not require any contact component, such as electrodes, and electric wires that are essential components for conventional smart fluids. In this work, the PR fluids were synthesized by doping lecithin/sodium deoxycholate reverse micelles with a photo-chromic spiropyran compound. It is demonstrated that the viscosity changes of PR fluids can be induced by UV light, and their rheological properties are examined in detail. In addition, an example of tailoring rheological properties using photoluminescence was introduced for improved response time. One of the potential applications, such as microfluidic flow control using the PR fluids, is also briefly presented.

Ultrasonic Apparatus and Technique to Measure Changes in Intracranial Pressure

NASA Technical Reports Server (NTRS)

Yost, William T. (Inventor); Cantrell, John H. (Inventor)

2002-01-01

Changes in intracranial pressure can be measured dynamically and non-invasively by monitoring one or more cerebrospinal fluid pulsatile components. Pulsatile components such as systolic and diastolic blood pressures are partially transferred to the cerebrospinal fluid by way of blood vessels contained in the surrounding brain tissue and membrane. As intracranial pressure varies these cerebrospinal fluid pulsatile components also vary. Thus, intracranial pressure can be dynamically measured. Furthermore, use of acoustics allows the measurement to be completely non-invasive. In the preferred embodiment, phase comparison of a reflected acoustic signal to a reference signal using a constant frequency pulsed phase-locked-loop ultrasonic device allows the pulsatile components to be monitored. Calibrating the device by inducing a known change in intracranial pressure allows conversion to changes in intracranial pressure.

Control of a three-dimensional turbulent shear layer by means of oblique vortices

NASA Astrophysics Data System (ADS)

Jürgens, Werner; Kaltenbach, Hans-Jakob

2018-04-01

The effect of local forcing on the separated, three-dimensional shear layer downstream of a backward-facing step is investigated by means of large-eddy simulation for a Reynolds number based on the step height of 10,700. The step edge is either oriented normal to the approaching turbulent boundary layer or swept at an angle of 40°. Oblique vortices with different orientation and spacing are generated by wavelike suction and blowing of fluid through an edge parallel slot. The vortices exhibit a complex three-dimensional structure, but they can be characterized by a wavevector in a horizontal section plane. In order to determine the step-normal component of the wavevector, a method is developed based on phase averages. The dependence of the wavevector on the forcing parameters can be described in terms of a dispersion relation, the structure of which indicates that the disturbances are mainly convected through the fluid. The introduced vortices reduce the size of the recirculation region by up to 38%. In both the planar and the swept case, the most efficient of the studied forcings consists of vortices which propagate in a direction that deviates by more than 50° from the step normal. These vortices exhibit a spacing in the order of 2.5 step heights. The upstream shift of the reattachment line can be explained by increased mixing and momentum transport inside the shear layer which is reflected in high levels of the Reynolds shear stress -ρ \\overline{u'v'}. The position of the maximum of the coherent shear stress is found to depend linearly on the wavelength, similar to two-dimensional free shear layers.

Final Scientific/Technical Report – DE-EE0002960 Recovery Act. Detachment faulting and Geothermal Resources - An Innovative Integrated Geological and Geophysical Investigation of Pearl Hot Spring, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stockli, Daniel F.

2015-11-30

The Pearl Host Spring Geothermal Project funded by the DoE Geothermal Program was a joint academic (KU/UT & OU) and industry collaboration (Sierra and Ram Power) to investigate structural controls and the importance of low-angle normal faults on geothermal fluid flow through a multifaceted geological, geophysical, and geochemical investigation in west-central Nevada. The study clearly showed that the geothermal resources in Clayton Valley are controlled by the interplay between low-angle normal faults and active deformation related to the Walker Lane. The study not only identified potentially feasible blind geothermal resource plays in eastern Clayton Valley, but also provide a transportablemore » template for exploration in the area of west-central Nevada and other regional and actively-deforming releasing fault bends. The study showed that deep-seated low-angle normal faults likely act as crustal scale permeability boundaries and could play an important role in geothermal circulation and funneling geothermal fluid into active fault zones. Not unique to this study, active deformation is viewed as an important gradient to rejuvenated fracture permeability aiding the long-term viability of blind geothermal resources. The technical approach for Phase I included the following components, (1) Structural and geological analysis of Pearl Hot Spring Resource, (2) (U-Th)/He thermochronometry and geothermometry, (3) detailed gravity data and modeling (plus some magnetic and resistivity), (4) Reflection and Refraction Seismic (Active Source), (5) Integration with existing and new geological/geophysical data, and (6) 3-D Earth Model, combining all data in an innovative approach combining classic work with new geochemical and geophysical methodology to detect blind geothermal resources in a cost-effective fashion.« less

Influence of Normal and Shear Stress on the Hydraulic Transmissivity of Thin Cracks in a Tight Quartz Sandstone, a Granite, and a Shale

NASA Astrophysics Data System (ADS)

Rutter, Ernest H.; Mecklenburgh, Julian

2018-02-01

Transmissivity of fluids along fractures in rocks is reduced by increasing normal stress acting across them, demonstrated here through gas flow experiments on Bowland shale, and oil flow experiments on Pennant sandstone and Westerly granite. Additionally, the effect of imposing shear stress at constant normal stress was determined, until frictional sliding started. In all cases, increasing shear stress causes an accelerating reduction of transmissivity by 1 to 3 orders of magnitude as slip initiated, as a result of the formation of wear products that block fluid pathways. Only in the case of granite, and to a lesser extent in the sandstone, was there a minor amount of initial increase of transmissivity prior to the onset of slip. These results cast into doubt the commonly applied presumption that cracks with high resolved shear stresses are the most conductive. In the shale, crack transmissivity is commensurate with matrix permeability, such that shales are expected always to be good seals. For the sandstone and granite, unsheared crack transmissivity was respectively 2 and 2.5 orders of magnitude greater than matrix permeability. For these rocks crack transmissivity can dominate fluid flow in the upper crust, potentially enough to permit maintenance of a hydrostatic fluid pressure gradient in a normal (extensional) faulting regime.

Synovial fluid bupivacaine concentrations following single intra-articular injection in normal and osteoarthritic canine stifles.

PubMed

Barry, S L; Martinez, S A; Davies, N M; Remsberg, C M; Sayre, C L; Bachelez, A

2015-02-01

Intra-articular bupivacaine helps alleviate pain in animals receiving joint surgery, but its use has become controversial as ex vivo studies have illuminated the potential for chondrotoxicity. Such studies typically involve cell cultures incubated in solutions containing high bupivacaine concentrations for long durations. The aim of this study was to measure the actual synovial fluid bupivacaine concentrations after intra-articular injection. Eight healthy beagles with normal stifles and 22 large and giant-breed dogs with stifle osteoarthritis (OA) were treated with a single intra-articular injection of bupivacaine (1 mg/kg) into a stifle. Joint fluid samples were taken from the treated stifle immediately after injection and 30 min after injection and analyzed for bupivacaine concentrations. Immediately after injection, the median bupivacaine concentrations in normal and OA stifles were 3.6 and 2.5 mg/mL, respectively. Thirty minutes after injection, bupivacaine concentrations in normal and OA stifles were 0.4 and 0.6 mg/mL, respectively. These results provide insight into the pharmacokinetics of bupivacaine after injection into a joint. Given its immediate dilution and rapid drop in synovial fluid concentration, bupivacaine is unlikely to damage chondrocytes when administered as a single intra-articular injection. © 2014 John Wiley & Sons Ltd.

Viscoelastic flow past mono- and bidisperse random arrays of cylinders: flow resistance, topology and normal stress distribution.

PubMed

De, S; Kuipers, J A M; Peters, E A J F; Padding, J T

2017-12-13

We investigate creeping viscoelastic fluid flow through two-dimensional porous media consisting of random arrangements of monodisperse and bidisperse cylinders, using our finite volume-immersed boundary method introduced in S. De, et al., J. Non-Newtonian Fluid Mech., 2016, 232, 67-76. The viscoelastic fluid is modeled with a FENE-P model. The simulations show an increased flow resistance with increase in flow rate, even though the bulk response of the fluid to shear flow is shear thinning. We show that if the square root of the permeability is chosen as the characteristic length scale in the determination of the dimensionless Deborah number (De), then all flow resistance curves collapse to a single master curve, irrespective of the pore geometry. Our study reveals how viscoelastic stresses and flow topologies (rotation, shear and extension) are distributed through the porous media, and how they evolve with increasing De. We correlate the local viscoelastic first normal stress differences with the local flow topology and show that the largest normal stress differences are located in shear flow dominated regions and not in extensional flow dominated regions at higher viscoelasticity. The study shows that normal stress differences in shear flow regions may play a crucial role in the increase of flow resistance for viscoelastic flow through such porous media.

Advances in cardiovascular fluid mechanics: bench to bedside.

PubMed

Dasi, Lakshmi P; Sucosky, Philippe; de Zelicourt, Diane; Sundareswaran, Kartik; Jimenez, Jorge; Yoganathan, Ajit P

2009-04-01

This paper presents recent advances in cardiovascular fluid mechanics that define the current state of the art. These studies include complex multimodal investigations with advanced measurement and simulation techniques. We first discuss the complex flows within the total cavopulmonary connection in Fontan patients. We emphasize the quantification of energy losses by studying the importance of caval offsets as well as the differences among various Fontan surgical protocols. In our studies of the fluid mechanics of prosthetic heart valves, we reveal for the first time the full three-dimensional complexity of flow fields in the vicinity of bileaflet and trileaflet valves and the microscopic hinge flow dynamics. We also present results of these valves functioning in a patient-specific native aorta geometry. Our in vitro mitral valve studies show the complex mechanism of the native mitral valve apparatus. We demonstrate that the different components of the mitral valve have independent and synergistically complex functions that allow the valve to operate efficiently. We also show how valve mechanics change under pathological and repair conditions associated with enlarged ventricles. Finally, our ex vivo studies on the interactions between the aortic valve and its surrounding hemodynamic environment are aimed at providing insights into normal valve function and valve pathology. We describe the development of organ- and tissue-culture systems and the biological response of the tissue subjected to their respective simulated mechanical environment. The studies noted above have enhanced our understanding of the complex fluid mechanics associated with the cardiovascular system and have led to new translational technologies.

Fluid handling equipment: A compilation

NASA Technical Reports Server (NTRS)

1976-01-01

Devices and techniques used in fluid-handling and vacuum systems are described. Section 1 presents several articles on fluid lines and tubing. Section 2 describes a number of components such as valves, filters, and regulators. The last section contains descriptions of a number of innovative fluid-handling systems.

On the relationship between executive functions of working memory and components derived from fluid intelligence measures.

PubMed

Ren, Xuezhu; Schweizer, Karl; Wang, Tengfei; Chu, Pei; Gong, Qin

2017-10-01

The aim of the current study is to provide new insights into the relationship between executive functions and intelligence measures in considering the item-position effect observed in intelligence items. Raven's Advanced Progressive Matrices (APM) and Horn's LPS reasoning test were used to assess fluid intelligence which served as criterion in investigating the relationship between intelligence and executive functions. A battery of six experimental tasks measured the updating, shifting, and inhibition processes of executive functions. Data were collected from 205 university students. Fluid intelligence showed substantial correlations with the updating and inhibition processes and no correlation with the shifting process without considering the item-position effect. Next, the fixed-link model was applied to APM and LPS data separately to decompose them into an ability component and an item-position component. The results of relating the components to executive functions showed that the updating and shifting processes mainly contributed to the item-position component whereas the inhibition process was mainly associated with the ability component of each fluid intelligence test. These findings suggest that improvements in the efficiency of updating and shifting processes are likely to occur during the course of completing intelligence measures and inhibition is important for intelligence in general. Copyright © 2017 Elsevier B.V. All rights reserved.

Methods for separation/purification utilizing rapidly cycled thermal swing sorption

DOEpatents

Tonkovich, Anna Lee Y.; Monzyk, Bruce F.; Wang, Yong; VanderWiel, David P.; Perry, Steven T.; Fitzgerald, Sean P.; Simmons, Wayne W.; McDaniel, Jeffrey S.; Weller, Jr., Albert E.

2004-11-09

The present invention provides apparatus and methods for separating fluid components. In preferred embodiments, the apparatus and methods utilize microchannel devices with small distances for heat and mass transfer to achieve rapid cycle times and surprisingly large volumes of fluid components separated in short times using relatively compact hardware.

14 CFR 25.1045 - Cooling test procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... not one during which component and the engine fluid temperatures would stabilize (in which case... cooling test must be preceded by a period during which the powerplant component and engine fluid temperatures are stabilized with the engines at ground idle. (c) Cooling tests for each stage of flight must be...

Parallel Three-Dimensional Computation of Fluid Dynamics and Fluid-Structure Interactions of Ram-Air Parachutes

NASA Technical Reports Server (NTRS)

Tezduyar, Tayfun E.

1998-01-01

This is a final report as far as our work at University of Minnesota is concerned. The report describes our research progress and accomplishments in development of high performance computing methods and tools for 3D finite element computation of aerodynamic characteristics and fluid-structure interactions (FSI) arising in airdrop systems, namely ram-air parachutes and round parachutes. This class of simulations involves complex geometries, flexible structural components, deforming fluid domains, and unsteady flow patterns. The key components of our simulation toolkit are a stabilized finite element flow solver, a nonlinear structural dynamics solver, an automatic mesh moving scheme, and an interface between the fluid and structural solvers; all of these have been developed within a parallel message-passing paradigm.

Generation of energy

DOEpatents

Kalina, Alexander I.

1984-01-01

A method of generating energy which comprises utilizing relatively lower temperature available heat to effect partial distillation of at least portion of a multicomponent working fluid stream at an intermediate pressure to generate working fluid fractions of differing compositions. The fractions are used to produce at least one main rich solution which is relatively enriched with respect to the lower boiling component, and to produce at least one lean solution which is relatively improverished with respect to the lower boiling component. The pressure of the main rich solution is increased whereafter it is evaporated to produce a charged gaseous main working fluid. The main working fluid is expanded to a low pressure level to release energy. The spent low pressure level working fluid is condensed in a main absorption stage by dissolving with cooling in the lean solution to regenerate an initial working fluid for reuse.

Diuretics prescribing in chronic kidney disease patients: physician assessment versus bioimpedence spectroscopy.

PubMed

Khan, Yusra Habib; Sarriff, Azmi; Adnan, Azreen Syazril; Khan, Amer Hayat; Mallhi, Tauqeer Hussain

2017-06-01

The relationship between hypertension and fluid overload in pre-dialysis CKD patients need to be elucidated. Current study aimed to find relationship between fluid overload and hypertension along with prescribed diuretic therapy using bioimpedance spectroscopy (BIS). A prospective observational study was conducted by inviting pre-dialysis CKD patients. Fluid overload was assessed by BIS. A total of 312 CKD patients with mean eGFR 24.5 ± 11.2 ml/min/1.73 m 2 were enrolled. Based on OH value ≥7 %, 135 (43.3 %) patients were hypervolemic while euvolemia was observed in 177 (56.7 %) patients. Patients were categorized in different regions of hydration reference plot (HRP) generated by BIS i.e., 5.1 % in region-N (normal BP and fluid status), 20.5 % in region I (hypertensive with severe fluid overload), 29.5 % in region I-II (hypertensive with mild fluid overload), 22 % in region II (hypertensive with normohydration), 10.2 % in region III (underhydration with normal/low BP) and 12.5 % in region IV (normal BP with severe fluid overload). A total of 144 (46 %) patients received diuretics on basis of physician assessment of BP and edema. Maximum diuretics 100 (69.4 %) were prescribed in patients belonging to regions I and I-II of HRP. Interestingly, a similar number of diuretic prescriptions were observed in region II (13 %) and region IV (12 %). Surprisingly, 7 (4.9 %) of patients in region III who were neither hypervolemic nor hypertensive were also prescribed with diuretics. BIS can aid clinicians to categorize CKD patients on basis of their fluid status and provide individualized pharmacotherapy to manage hypertensive CKD patients.

Magnetic field effects on shear and normal stresses in magnetorheological finishing.

PubMed

Lambropoulos, John C; Miao, Chunlin; Jacobs, Stephen D

2010-09-13

We use a recent experimental technique to measure in situ shear and normal stresses during magnetorheological finishing (MRF) of a borosilicate glass over a range of magnetic fields. At low fields shear stresses increase with magnetic field, but become field-independent at higher magnetic fields. Micromechanical models of formation of magnetic particle chains suggest a complex behavior of magnetorheological (MR) fluids that combines fluid- and solid-like responses. We discuss the hypothesis that, at higher fields, slip occurs between magnetic particle chains and the immersed glass part, while the normal stress is governed by the MRF ribbon elasticity.

Hydrocephalus

MedlinePlus

... buildup of too much cerebrospinal fluid in the brain. Normally, this fluid cushions your brain. When you have too much, though, it puts harmful pressure on your brain. Hydrocephalus can be congenital, or present at birth. ...

Method of moments for the dilute granular flow of inelastic spheres

NASA Astrophysics Data System (ADS)

Strumendo, Matteo; Canu, Paolo

2002-10-01

Some peculiar features of granular materials (smooth, identical spheres) in rapid flow are the normal pressure differences and the related anisotropy of the velocity distribution function f(1). Kinetic theories have been proposed that account for the anisotropy, mostly based on a generalization of the Chapman-Enskog expansion [N. Sela and I. Goldhirsch, J. Fluid Mech. 361, 41 (1998)]. In the present paper, we approach the problem differently by means of the method of moments; previously, similar theories have been constructed for the nearly elastic behavior of granular matter but were not able to predict the normal pressures differences. To overcome these restrictions, we use as an approximation of the f(1) a truncated series expansion in Hermite polynomials around the Maxwellian distribution function. We used the approximated f(1) to evaluate the collisional source term and calculated all the resulting integrals; also, the difference in the mean velocity of the two colliding particles has been taken into account. To simulate the granular flows, all the second-order moment balances are considered together with the mass and momentum balances. In balance equations of the Nth-order moments, the (N+1)th-order moments (and their derivatives) appear: we therefore introduced closure equations to express them as functions of lower-order moments by a generalization of the ``elementary kinetic theory,'' instead of the classical procedure of neglecting the (N+1)th-order moments and their derivatives. We applied the model to the translational flow on an inclined chute obtaining the profiles of the solid volumetric fraction, the mean velocity, and all the second-order moments. The theoretical results have been compared with experimental data [E. Azanza, F. Chevoir, and P. Moucheront, J. Fluid Mech. 400, 199 (1999); T. G. Drake, J. Fluid Mech. 225, 121 (1991)] and all the features of the flow are reflected by the model: the decreasing exponential profile of the solid volumetric fraction, the parabolic shape of the mean velocity, the constancy of the granular temperature and of its components. Besides, the model predicts the normal pressures differences, typical of the granular materials.

Microencapsulated PCM slurries for heat transfer and energy storage in spacecraft systems

NASA Astrophysics Data System (ADS)

Colvin, David P.; Mulligan, James C.; Bryant, Yvonne G.; Duncan, John L.; Gravely, Benjamin T.

The technical feasibility for providing significantly enhanced heat transport and storage as well as improved thermal control has been investigated during several Small Business Innovative Research (SBIR) programs for NASA, the United States Air Force (USAF), and the Strategic Defense Initiative Organization (SDIO) using microencapsulated phase change materials (PCMs) in both aqueous and nonaqueous two-component slurries. In the program for SDIO, novel two-component coolant fluids were prepared and successfully tested at both low (300 K) and intermediate temperatures (460 to 700 K). The two-component fluid slurries of microencapsulated PCMs included organic particles in aqueous and nonaqueous liquids, as well as microencapsulated metals that potentially could be carried by liquid metals or used as powdered heat sinks. Simulation and experimental studies showed that such active cooling systems could be designed and operated with enhancements of heat capacity that exceeded 10 times or 1000 percent that for the base fluid along with significant enhancement in the fluid's heat capacity. Furthermore, this enhancement provided essentially isothermal conditions throughout the pumped primary coolant fluid loop. The results suggest that together with much higher fluid thermal capacity, greater uniformity of temperature is achievable with such fluids, and that significant reductions in pumping power, system size, and system mass are also possible.

Suppressing magnetic island growth by resonant magnetic perturbation

NASA Astrophysics Data System (ADS)

Yu, Q.; Günter, S.; Lackner, K.

2018-05-01

The effect of externally applied resonant magnetic perturbations (RMPs) on the growth of magnetic islands is investigated based on two-fluid equations. It is found that if the local bi-normal electron fluid velocity at the resonant surface is sufficiently large, static RMPs of the same helicity and of moderate amplitude can suppress the growth of magnetic islands in high-temperature plasmas. These islands will otherwise grow, driven by an unfavorable plasma current density profile and bootstrap current perturbation. These results indicate that the error field can stabilize island growth, if the error field amplitude is not too large and the local bi-normal electron fluid velocity is not too low. They also indicate that applied rotating RMPs with an appropriate frequency can be utilized to suppress island growth in high-temperature plasmas, even for a low bi-normal electron fluid velocity. A significant change in the local equilibrium plasma current density gradient by small amplitude RMPs is found for realistic plasma parameters, which are important for the island stability and are expected to be more important for fusion reactors with low plasma resistivity.

Advanced spatiotemporal mapping methods give new insights into the coordination of contractile activity in the stomach of the rat.

PubMed

Lentle, R G; Reynolds, G W; Hulls, C M; Chambers, J P

2016-12-01

We used spatiotemporal mapping of strain rate to determine the direction of propagation and amplitudes of the longitudinal and circumferential components of antrocorporal (AC) contractions and fundal contractions in the rat stomach maintained ex vivo and containing a volume of fluid that was within its normal functional capacity. In the region of the greater curvature the longitudinal and circular components of AC contractions propagated synchronously at right angles to the arciform geometric axis of the stomach. However, the configuration of AC contractions was U shaped, neither the circular nor the longitudinal component of contractions being evident in the upper proximal corpus. Similarly, in the distal upper antrum of some preparations, circumferential components propagated more rapidly than longitudinal components. Ongoing "high-frequency, low-amplitude myogenic contractions" were identified in the upper proximal gastric corpus and on the anterior and posterior wall of the fundus. The amplitudes of these contractions were modulated in the occluded stomach by low-frequency pressure waves that occurred spontaneously. Hence the characteristics of phasic contractions vary regionally in the antrum and corpus and a previously undescribed high-frequency contractile component was identified in the proximal corpus and fundus, the latter being modulated in synchrony with cyclic variation in intrafundal pressure in the occluded fundus. Copyright © 2016 the American Physiological Society.

Cystic Fibrosis Heterozygote Resistance to Cholera Toxin in the Cystic Fibrosis Mouse Model

NASA Astrophysics Data System (ADS)

Gabriel, Sherif E.; Brigman, Kristen N.; Koller, Beverly H.; Boucher, Richard C.; Stutts, M. Jackson

1994-10-01

The effect of the number of cystic fibrosis (CF) alleles on cholera toxin (CT)-induced intestinal secretion was examined in the CF mouse model. CF mice that expressed no CF transmembrane conductance regulator (CFTR) protein did not secrete fluid in response to CT. Heterozygotes expressed 50 percent of the normal amount of CFTR protein in the intestinal epithelium and secreted 50 percent of the normal fluid and chloride ion in response to CT. This correlation between CFTR protein and CT-induced chloride ion and fluid secretion suggests that CF heterozygotes might possess a selective advantage of resistance to cholera.

Origin and timing of Dauphiné twins in quartz cement in fractured sandstones from diagenetic environments: Insight from fluid inclusions

NASA Astrophysics Data System (ADS)

Fall, András; Ukar, Estibalitz; Laubach, Stephen E.

2016-09-01

Electron backscattered diffraction techniques (EBSD) show that Dauphiné twins in quartz are widespread in many tectonometamorphic environments. Our study documents that under diagenetic temperatures (< 200 °C) and burial depths < 5 km Dauphiné twins are common in isolated fracture quartz deposits spanning between fracture walls (i.e., quartz bridges) in low-porosity quartz-cemented sandstones. Using examples from East Texas and Colorado cores, we show that twins are associated with crack-seal microstructure and fluid inclusions. Fracture wall-parallel and wall-normal inclusion trails contain coexisting aqueous and hydrocarbon gas inclusions, so homogenization temperatures of aqueous inclusions record true trapping temperatures. Inclusions in alignments normal to fracture walls are large and irregularly shaped compared to those aligned parallel to walls, but both show similar liquid-to-vapor ratios. Stacking transmitted light images with scanning electron microscope cathodoluminescence (SEM-CL) and EBSD images demonstrates that Dauphiné twin boundaries are localized along wall-normal inclusion trails. Trapping temperatures for wall-normal inclusion trails are usually higher than those aligned parallel to the fracture wall. Wall-normal fluid inclusion assemblage temperatures typically match the highest temperatures of wall-parallel assemblages trapped during sequential widening, but not necessarily the most recent. In context of burial histories for these samples, this temperature pattern implies that wall-normal assemblages form at discrete times during or after crack-seal fracture widening. Localization in isolated, potentially high-stress quartz deposits in fractures is compatible with a mechanical origin for these Dauphiné twins. Punctuated temperature values and discrepant sizes and shapes of inclusions in wall-normal trails implies that twinning is a by-product of the formation of the wall-normal inclusion assemblages. The association of Dauphiné twins and fluid inclusion assemblages from which temperature and possibly timing can be inferred provides a way to research timing as well as magnitude of paleostress in some diagenetic settings.

Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis

PubMed Central

2017-01-01

Protein-depleted states generate allosteric inhibition of liver cystathionine β-synthase (CBS), which governs the first enzymatic step of the transsulfuration cascade, resulting in upstream accretion of homocysteine (Hcy) in body fluids. A similar Hcy increase may arise from normal hepatocytes undergoing experimentally-induced impairment of betaine-homocysteine methyltransferase (BHTM) activity or from components of lean body mass (LBM) submitted to any inflammatory disorder. LBM comprises a composite agglomeration of extrarenal tissues characterized by naturally occurring BHTM inactivity. As a result of cellular injury, LBM releases high concentrations of Hcy into the extracellular space, contrasting with the disruption of normal remethylation pathways. Hyperhomocysteinemia acts as a biomarker, reflecting the severity of insult and operating as an alarm signal. Elevated Hcy levels constitute a precursor pool recognized by a CBS coding region that reacts to meet increased methionine requirements in LBM tissues, using its enhanced production in hepatocytes. Preservation of methionine homeostasis benefits from its high metabolic priority and survival value. PMID:28930162

Intracranial and Intraocular Pressure at the Lamina Cribrosa: Gradient Effects.

PubMed

Jóhannesson, Gauti; Eklund, Anders; Lindén, Christina

2018-04-12

A pressure difference between the intraocular and intracranial compartments at the site of the lamina cribrosa has been hypothesized to have a pathophysiological role in several optic nerve head diseases. This paper reviews the current literature on the translamina cribrosa pressure difference (TLCPD), the associated pressure gradient, and its potential pathophysiological role, as well as the methodology to assess TLCPD. For normal-tension glaucoma (NTG), initial studies indicated low intracranial pressure (ICP) while recent findings indicate that a reduced ICP is not mandatory. Data from studies on the elevated TLCPD as a pathophysiological factor of NTG are equivocal. From the identification of potential postural effects on the cerebrospinal fluid (CSF) communication between the intracranial and retrolaminar space, we hypothesize that the missing link could be a dysfunction of an occlusion mechanism of the optic nerve sheath around the optic nerve. In upright posture, this could cause an elevated TLCPD even with normal ICP and we suggest that this should be investigated as a pathophysiological component in NTG patients.

Identification and tracking of hairpin vortex auto-generation in turbulent wall-bounded flow

NASA Astrophysics Data System (ADS)

Huang, Yangzi; Green, Melissa

2016-11-01

Hairpin vortices have been widely accepted as component structures of turbulent boundary layers. Their properties (size, vorticity, energy) and dynamic phenomena (origin, growth, breakdown) have been shown to correlate to the complex, multi-scaled turbulent motions observed in both experiments and simulations. As established in the literature, the passage of a hairpin vortex creates a wall-normal ejection of fluid, which encounters the high-speed freestream resulting in near-wall shear and increased drag. A previously generated simulation of an isolated hairpin vortex is used to study the auto-generation of a secondary vortex structure. Eulerian methods such as the Q criterion and Γ2 function, as well as Lagrangian methods are used to visualize the three-dimensional hairpin vortices and the auto-generation process. The circulation development and wall-normal location of both primary and secondary hairpin heads are studied to determine if there is a correlation between the strength and height of the primary hairpin vortex with the secondary hairpin vortex auto-generation.

Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis.

PubMed

Ingenbleek, Yves

2017-09-20

Protein-depleted states generate allosteric inhibition of liver cystathionine β-synthase (CBS), which governs the first enzymatic step of the transsulfuration cascade, resulting in upstream accretion of homocysteine (Hcy) in body fluids. A similar Hcy increase may arise from normal hepatocytes undergoing experimentally-induced impairment of betaine-homocysteine methyltransferase (BHTM) activity or from components of lean body mass (LBM) submitted to any inflammatory disorder. LBM comprises a composite agglomeration of extrarenal tissues characterized by naturally occurring BHTM inactivity. As a result of cellular injury, LBM releases high concentrations of Hcy into the extracellular space, contrasting with the disruption of normal remethylation pathways. Hyperhomocysteinemia acts as a biomarker, reflecting the severity of insult and operating as an alarm signal. Elevated Hcy levels constitute a precursor pool recognized by a CBS coding region that reacts to meet increased methionine requirements in LBM tissues, using its enhanced production in hepatocytes. Preservation of methionine homeostasis benefits from its high metabolic priority and survival value.

Slip behaviour of carbonate-bearing faults subjected to fluid pressure stimulations

NASA Astrophysics Data System (ADS)

Collettini, Cristiano; Scuderi, Marco; Marone, Chris

2017-04-01

Earthquakes caused by fluid injection within reservoir have become an important topic of political and social discussion as new drilling and improved technologies enable the extraction of oil and gas from previously unproductive formations. During reservoir stimulation, the coupled interactions of frictional and fluid flow properties together with the stress state control both the onset of fault slip and fault slip behaviour. However, currently, there are no studies under controlled, laboratory conditions for which the effect of fluid pressure on fault slip behaviour can be deduced. To cover this gap, we have developed laboratory experiments where we monitor fault slip evolution at constant shear stress but with increasing fluid pressure, i.e. reducing the effective normal stress. Experiments have been conducted in the double direct shear configuration within a pressure vessel on carbonate fault gouge, characterized by a slightly velocity strengthening friction that is indicative of stable aseismic creep. In our experiments fault slip history can be divided in three main stages: 1) for high effective normal stress the fault is locked and undergoes compaction; 2) when the shear and effective normal stress reach the failure condition, accelerated creep is associated to fault dilation; 3) further pressurization leads to an exponential acceleration during fault compaction and slip localization. Our results indicate that fault weakening induced by fluid pressurization overcomes the velocity strengthening behaviour of calcite gouge, resulting in fast acceleration and earthquake slip. As applied to tectonic faults our results suggest that a larger number of crustal faults, including those slightly velocity strengthening, can experience earthquake slip due to fluid pressurization.

A High Performance Computing Approach to the Simulation of Fluid Solid Interaction Problems with Rigid and Flexible Components (Open Access Publisher’s Version)

DTIC Science & Technology

2014-08-01

performance computing, smoothed particle hydrodynamics, rigid body dynamics, flexible body dynamics ARMAN PAZOUKI ∗, RADU SERBAN ∗, DAN NEGRUT ∗ A...HIGH PERFORMANCE COMPUTING APPROACH TO THE SIMULATION OF FLUID-SOLID INTERACTION PROBLEMS WITH RIGID AND FLEXIBLE COMPONENTS This work outlines a unified...are implemented to model rigid and flexible multibody dynamics. The two- way coupling of the fluid and solid phases is supported through use of

A fluidic diode, valves, and a sequential-loading circuit fabricated on layered paper.

PubMed

Chen, Hong; Cogswell, Jeremy; Anagnostopoulos, Constantine; Faghri, Mohammad

2012-08-21

Current microfluidic paper-based devices lack crucial components for fluid manipulation. We created a fluidic diode fabricated entirely on a single layer of paper to control the wicking of fluids. The fluidic diode is a two-terminal component that promotes or stops wicking along a paper channel. We further constructed a trigger and a delay valve based on the fluidic diode. Furthermore, we demonstrated a high-level functional circuit, consisting of a diode and a delay valve, to manipulate two fluids in a sequential manner. Our study provides new, transformative tools to manipulate fluid in microfluidic paper-based devices.

Fluid coupling in a discrete model of cochlear mechanics.

PubMed

Elliott, Stephen J; Lineton, Ben; Ni, Guangjian

2011-09-01

A discrete model of cochlear mechanics is introduced that includes a full, three-dimensional, description of fluid coupling. This formulation allows the fluid coupling and basilar membrane dynamics to be analyzed separately and then coupled together with a simple piece of linear algebra. The fluid coupling is initially analyzed using a wavenumber formulation and is separated into one component due to one-dimensional fluid coupling and one comprising all the other contributions. Using the theory of acoustic waves in a duct, however, these two components of the pressure can also be associated with a far field, due to the plane wave, and a near field, due to the evanescent, higher order, modes. The near field components are then seen as one of a number of sources of additional longitudinal coupling in the cochlea. The effects of non-uniformity and asymmetry in the fluid chamber areas can also be taken into account, to predict both the pressure difference between the chambers and the mean pressure. This allows the calculation, for example, of the effect of a short cochlear implant on the coupled response of the cochlea. © 2011 Acoustical Society of America

Scaled Particle Theory for Multicomponent Hard Sphere Fluids Confined in Random Porous Media.

PubMed

Chen, W; Zhao, S L; Holovko, M; Chen, X S; Dong, W

2016-06-23

The formulation of scaled particle theory (SPT) is presented for a quite general model of fluids confined in a random porous media, i.e., a multicomponent hard sphere (HS) fluid in a multicomponent hard sphere or a multicomponent overlapping hard sphere (OHS) matrix. The analytical expressions for pressure, Helmholtz free energy, and chemical potential are derived. The thermodynamic consistency of the proposed theory is established. Moreover, we show that there is an isomorphism between the SPT for a multicomponent system and that for a one-component system. Results from grand canonical ensemble Monte Carlo simulations are also presented for a binary HS mixture in a one-component HS or a one-component OHS matrix. The accuracy of various variants derived from the basic SPT formulation is appraised against the simulation results. Scaled particle theory, initially formulated for a bulk HS fluid, has not only provided an analytical tool for calculating thermodynamic properties of HS fluid but also helped to gain very useful insight for elaborating other theoretical approaches such as the fundamental measure theory (FMT). We expect that the general SPT for multicomponent systems developed in this work can contribute to the study of confined fluids in a similar way.

Anomalous Hydrodynamics and Normal Fluids in Rapidly Rotating Bose-Einstein Condensates

NASA Astrophysics Data System (ADS)

Bourne, A.; Wilkin, N. K.; Gunn, J. M. F.

2006-06-01

In rapidly rotating condensed Bose systems we show that there is a regime of anomalous hydrodynamics which coincides with the mean field quantum Hall regime. A consequence is the absence of a normal fluid in any conventional sense. However, even the superfluid hydrodynamics is not described by conventional Bernoulli and continuity equations. We show that there are constraints which connect spatial variations of density and phase and that the vortex positions are not the simplest description of the dynamics. We demonstrate, inter alia, a simple relation between vortices and surface waves. We show that the surface waves can emulate a “normal fluid,” allowing dissipation by energy and angular momentum absorbtion from vortex motion in the trap. The time scale is sensitive to the initial configuration, which can lead to long-lived vortex patches—perhaps related to those observed at JILA.

Structural cooling fluid tube for supporting a turbine component and supplying cooling fluid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Charron, Richard; Pierce, Daniel

2015-02-24

A shaft cover support for a gas turbine engine is disclosed. The shaft cover support not only provides enhanced support to a shaft cover of the gas turbine engine, but also includes a cooling fluid chamber for passing fluids from a rotor air cooling supply conduit to an inner ring cooling manifold. As such, the shaft cover support accomplishes in a single component what was only partially accomplished in two components in conventional configurations. The shaft cover support may also provide additional stiffness and reduce interference of the flow from the compressor. In addition, the shaft cover support accommodates amore » transition section extending between compressor and turbine sections of the engine. The shaft cover support has a radially extending region that is offset from the inlet and outlet that enables the shaft cover support to surround the transition, thereby reducing the overall length of this section of the engine.« less

14 CFR 25.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Flammable fluid fire protection. 25.863....863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might escape by..., fireproof containment, or use of extinguishing agents. (5) Ability of airplane components that are critical...

14 CFR 27.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Flammable fluid fire protection. 27.863....863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might escape by..., fireproof containment, or use of extinguishing agents. (5) Ability of rotorcraft components that are...

14 CFR 27.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Flammable fluid fire protection. 27.863....863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might escape by..., fireproof containment, or use of extinguishing agents. (5) Ability of rotorcraft components that are...

14 CFR 25.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Flammable fluid fire protection. 25.863....863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might escape by..., fireproof containment, or use of extinguishing agents. (5) Ability of airplane components that are critical...

14 CFR 25.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Flammable fluid fire protection. 25.863....863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might escape by..., fireproof containment, or use of extinguishing agents. (5) Ability of airplane components that are critical...

14 CFR 27.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Flammable fluid fire protection. 27.863....863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might escape by..., fireproof containment, or use of extinguishing agents. (5) Ability of rotorcraft components that are...

14 CFR 25.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Flammable fluid fire protection. 25.863....863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might escape by..., fireproof containment, or use of extinguishing agents. (5) Ability of airplane components that are critical...

14 CFR 27.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Flammable fluid fire protection. 27.863....863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might escape by..., fireproof containment, or use of extinguishing agents. (5) Ability of rotorcraft components that are...

14 CFR 27.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Flammable fluid fire protection. 27.863....863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might escape by..., fireproof containment, or use of extinguishing agents. (5) Ability of rotorcraft components that are...

Host DNA Synthesis-Suppressing Factor in Culture Fluid of Tissue Cultures Infected with Measles Virus

PubMed Central

Minagawa, Tomonori; Nakaya, Chikako; Iida, Hiroo

1974-01-01

Host DNA synthesis is suppressed by the culture fluid of cell cultures infected with measles virus. This activity in the culture fluid is initiated somewhat later than the growth of infectious virus. Ninety percent of host DNA synthesis in HeLa cells is inhibited by culture fluid of 3-day-old cell cultures of Vero or HeLa cells infected with measles virus. This suppressing activity is not a property of the virion, but is due to nonvirion-associated component which shows none of the activities of measles virus such as hemagglutination, hemolysis, or cell fusion nor does it have the antigenicity of measles virus as tested by complement-fixation or hemagglutination-inhibiting antibody blocking tests. Neutralization of the activity of this component is not attained with the pooled sera of convalescent measles patients. This component has molecular weights of about 45,000, 20,000, and 3,000 and appears to be a heat-stable protein. The production of host DNA suppressing factor (DSF) is blocked by cycloheximide. Neither UV-inactivated nor antiserum-neutralized measles virus produce DSF. Furthermore, such activity of nonvirion-associated component is not detected in the culture fluid of cultures infected with other RNA viruses such as poliovirus, vesicular stomatitis virus, or Sindbis virus. PMID:4207526

Normal pressure hydrocephalus

MedlinePlus

Ferri FF. Normal pressure hydrocephalus. In: Ferri FF, ed. Ferri's Clinical Advisor 2016 . Philadelphia, PA: Elsevier; 2016:chap 648. Rosenberg GA. Brain edema and disorders of cerebrospinal fluid circulation. ...

Patterns of pulmonary maturation in normal and abnormal pregnancy.

PubMed

Goldkrand, J W; Slattery, D S

1979-03-01

Fetal pulmonary maturation may be a variable event depending on various feto-maternal environmental and biochemical influences. The patterns of maturation were studied in 211 amniotic fluid samples from 123 patients (normal 55; diabetes 23; Rh sensitization 19; preeclampsia 26). The phenomenon of globule formation from the amniotic fluid lipid extract and is relation to pulmonary maturity was utilized for this analysis. Validation of this technique is presented. A normal curve was constructed from 22 to 42 weeks; gestation and compared to the abnormal pregnancies. Patients with class A, B, and C diabetes and Rh-sensitized pregnancies had delayed pulmonary maturation. Patients with class D diabetes and preclampsia paralleled the normal course of maturation. A discussion of these results and their possible cause is presented.

Acoustic-gravity waves in atmospheric and oceanic waveguides.

PubMed

Godin, Oleg A

2012-08-01

A theory of guided propagation of sound in layered, moving fluids is extended to include acoustic-gravity waves (AGWs) in waveguides with piecewise continuous parameters. The orthogonality of AGW normal modes is established in moving and motionless media. A perturbation theory is developed to quantify the relative significance of the gravity and fluid compressibility as well as sensitivity of the normal modes to variations in sound speed, flow velocity, and density profiles and in boundary conditions. Phase and group speeds of the normal modes are found to have certain universal properties which are valid for waveguides with arbitrary stratification. The Lamb wave is shown to be the only AGW normal mode that can propagate without dispersion in a layered medium.

PAROTID FLUID TOTAL PROTEIN IN PATIENTS WITH UREMIA AND PROTEINURIA.

DTIC Science & Technology

Stimulated parotid fluid samples (238) were collected from 32 patients to determine if altered renal function was associated with deviations in...tubular necrosis, and 15 had normal renal function. There were no significant differences in parotid fluid protein concentration or minute secretion associated with the state of renal function. (Author)

EFFECTS OF PREDNISOLONE AND TRIAMCINOLONE ON CORTICOSTEROID LEVELS IN PAROTID FLUID, SERUM, AND URINE.

DTIC Science & Technology

A simultaneous determination was made of 17-OHCS in serum, urine, and parotid fluid, by the Porter-Silber reaction, after the oral administration of...prednisolone, triamcinolone, or placebo to 240 normal human subjects. The data clearly demonstrate the homology of serum and parotid fluid 17-OHCS

Primary Total Knee Replacement: Is Suction a Portal of Infection?

PubMed Central

Budnar, Vijaya M; Amirfeyz, Rouin; Ng, Michael; Bannister, Gordon C; Blom, Ashley W

2009-01-01

INTRODUCTION Pulsed lavage during a total knee replacement usually leaves a pool of fluid on the surgical drapes. It is common practice to suck away this fluid using the same suction device used intra-operatively. This could be a cause of direct wound contamination. We hypothesised that bacteria contaminate fluid that collects around the foot in total knee replacement surgery and that suction equipment could be a portal of contamination. We also hypothesised that bacterial count in the fluid is lower if chlorhexidine, rather than saline, is used in the pulsed lavage. PATIENTS AND METHODS Forty patients undergoing primary total knee replacement were divided into two groups. The first group had pulsed lavage with normal saline and the second with 0.05% chlorhexidine. RESULTS At the end of the operation, 20 ml of fluid, pooled on the surgical drapes was aspirated and cultured for bacterial growth. None of the fluid samples showed bacterial growth. CONCLUSIONS Suction device used peri-operatively during knee replacement is unlikely to be a cause of wound contamination. Pulsed lavage with normal saline is as effective as lavage with chlorhexidine. PMID:19335972

An unusual case of recurrent Guillain-Barré syndrome with normal cerebrospinal fluid protein levels: a case report.

PubMed

Gunatilake, Sonali Sihindi Chapa; Gamlath, Rohitha; Wimalaratna, Harith

2016-09-05

Guillain-Barré syndrome is an acquired polyradiculo-neuropathy, often preceded by an antecedent event. It is a monophasic disease but a recurrence rate of 1-6 % is documented in a subset group of patients. Patients with Guillain-Barré syndrome show cerebrospinal fluid albuminocytologic dissociation. Normal cerebrospinal fluid protein levels during both initial and recurrent episodes of Guillain-Barré syndrome is a rare occurrence and has not been described earlier in the literature. Twenty-five-year-old Sri Lankan female with past history of complete recovery following an acute inflammatory demyelinating polyneuropathy (AIDP) variant of Guillain-Barré syndrome 12 years back presented with acute, ascending symmetrical flaccid quadriparasis extending to bulbar muscles, bilateral VII cranial nerves and respiratory compromise needing mechanical ventilation. Nerve conduction study revealed AIDP variant of Guillain-Barré syndrome. Cerebrospinal fluid analysis done after 2 weeks were normal during both episodes without albuminocytologic dissociation. She was treated with intravenous immunoglobulin resulting in a remarkable recovery. Both episodes had a complete clinical recovery in three and four months' time respectively, rather a faster recovery than usually expected. Recurrence of Guillain-Barré syndrome can occur in a subset of patients with Guillain-Barré syndrome even after many years of asymptomatic period. Normal cerebrospinal fluid profile does not exclude Guillain-Barré syndrome and may occur in subsequent recurrences of Guillain-Barré syndrome arising the need for further studies to identify the pathophysiology and the possibility of a different subtype of Guillain-Barré syndrome.

Analysis of minerals containing dissolved traces of the fluid phase components water and carbon dioxide

NASA Technical Reports Server (NTRS)

Freund, Friedemann

1991-01-01

Substantial progress has been made towards a better understanding of the dissolution of common gas/fluid phase components, notably H2O and CO2, in minerals. It has been shown that the dissolution mechanisms are significantly more complex than currently believed. By judiciously combining various solid state analytical techniques, convincing evidence was obtained that traces of dissolved gas/fluid phase components undergo, at least in part, a redox conversion by which they split into reduced H2 and and reduced C on one hand and oxidized oxygen, O(-), on the other. Analysis for 2 and C as well as for any organic molecules which may form during the process of co-segregation are still impeded by the omnipresent danger of extraneous contamination. However, the presence of O(-), an unusual oxidized form of oxygen, has been proven beyond a reasonable doubt. The presence of O(-) testifies to the fact that a redox reaction must have taken place in the solid state involving the dissolved traces of gas/fluid phase components. Detailed information on the techniques used and the results obtained are given.

Amniotic fluid cortisol and alpha-fetoprotein in normal and aneuploid pregnancies.

PubMed

Drugan, A; Subramanian, M G; Johnson, M P; Evans, M I

1988-01-01

Cortisol and alpha-fetoprotein (AFP) levels were measured in amniotic fluid (AF) samples at 15-20 weeks of gestation from 125 normal pregnancies and 29 pregnancies affected by aneuploidy. The normal pregnancy group was further subdivided into 'low' AF-AFP (less than 0.6 MOM, n = 60) and 'normal' AF-AFP (0.6 less than AFP less than 1.4 MOM, n = 65). A significant, inverse, linear correlation was found between cortisol and AF-AFP for both normal AFP and low AFP groups (r = -0.26, and r = -0.4, respectively, p less than 0.05). Gestational age was significantly correlated with both cortisol and AFP levels in the normal pregnancy groups. No difference was found when cortisol levels were compared between the low and normal AFP groups. The correlation between cortisol and AFP in aneuploid pregnancies was not significant (p = 0.37). The strong association between cortisol or AFP and gestational age in normal pregnancy (p less than 0.00001) was lost in trisomic gestation. We conclude that higher cortisol levels do not seem to be the cause of low AFP in normal or aneuploid pregnancies.

Thallium as a tracer of fluid-rock interaction in the shallow Mariana forearc

NASA Astrophysics Data System (ADS)

Nielsen, Sune G.; Klein, Frieder; Kading, Tristan; Blusztajn, Jerzy; Wickham, Katie

2015-11-01

Fluids driven off the subducting Pacific plate infiltrate the shallow Mariana forearc and lead to extensive serpentinization of mantle peridotite. However, the sources, pathways, and chemical modifications of ascending, slab-derived fluids remain poorly constrained and controversial. In this study, we use thallium (Tl) concentrations and isotopic ratios of serpentinized peridotite and rodingitized diabase from the South Chamorro and Conical Seamounts to discriminate between potential fluid sources with distinct Tl isotope compositions. Serpentinite samples from the Mariana forearc all display ε205 Tl > - 0.5 (where ε205 Tl = 10 , 000 × (205Tl /Tl203sample -205Tl /SRM 997 203Tl ) / (205Tl / SRM 997 203Tl )), which is significantly enriched in 205Tl compared to the normal mantle (ε205 Tl = - 2). Given that high temperature hydrothermal processes do not impart significant Tl isotope fractionation, the isotope compositions of the serpentinites must reflect that of the serpentinizing fluid. Pelagic sediments are the only known slab component that consistently displays ε205 Tl > - 0.5 and, therefore, we interpret the heavy Tl isotope signatures as signifying that the serpentinizing fluids were derived from subducting pelagic sediments. A rodingitized diabase from Conical Seamount was found to have an ε205 Tl of 0.8, suggesting that sediment-sourced serpentinization fluids could also affect diabase and other mafic lithologies in the shallow Mariana forearc. Forearc rodingitization of diabase led to a strong depletion in Tl content and a virtually complete loss of K, Na and Rb. The chemical composition of hybrid fluids resulting from serpentinization of harzburgite with concomitant rodingitization of diabase can be highly alkaline, depleted in Si, yet enriched in Ca, Na, K, and Rb, which is consistent with the composition of fluids emanating from mud volcanoes in the Mariana forearc. Our study suggests that fluid-rock interactions between sedimentary, mafic, and ultramafic lithologies are strongly interconnected even in the shallowest parts of subduction zones. We conclude that transfer of fluids and dissolved elements at temperatures and pressures below 400 °C and 1 GPa, respectively, must be taken into account when elemental budgets and mass transfer between the subducting plate, the forearc, the deep mantle and the ocean are evaluated.

Critical conditions for the buoyancy-driven detachment of a wall-bound pendant drop

NASA Astrophysics Data System (ADS)

Lamorgese, A.; Mauri, R.

2016-03-01

We investigate numerically the critical conditions for detachment of an isolated, wall-bound emulsion droplet acted upon by surface tension and wall-normal buoyancy forces alone. To that end, we present a simple extension of a diffuse-interface model for partially miscible binary mixtures that was previously employed for simulating several two-phase flow phenomena far and near the critical point [A. G. Lamorgese et al. "Phase-field approach to multiphase flow modeling," Milan J. Math. 79(2), 597-642 (2011)] to allow for static contact angles other than 90°. We use the same formulation of the Cahn boundary condition as first proposed by Jacqmin ["Contact-line dynamics of a diffuse fluid interface," J. Fluid Mech. 402, 57-88 (2000)], which accommodates a cubic (Hermite) interpolation of surface tensions between the wall and each phase at equilibrium. We show that this model can be successfully employed for simulating three-phase contact line problems in stable emulsions with nearly immiscible components. We also show a numerical determination of critical Bond numbers as a function of static contact angle by phase-field simulation.

Seismic evidence for hydration of the Central American slab: Guatemala through Costa Rica

NASA Astrophysics Data System (ADS)

Syracuse, E. M.; Thurber, C. H.

2011-12-01

The Central American subduction zone exhibits a wide variability in along-arc slab hydration as indicated by geochemical studies. These studies generally show maximum slab contributions to magma beneath Nicaragua and minimum contributions beneath Costa Rica, while intermediate slab fluid contributions are found beneath El Salvador and Guatemala. Geophysical studies suggest strong slab serpentinization and fluid release beneath Nicaragua, and little serpentinization beneath Costa Rica, but the remainder of the subduction zone is poorly characterized seismically. To obtain an integrated seismic model for the Central American subduction zone, we combine 250,000 local seismic arrivals and 1,000,000 differential arrivals for 6,500 shallow and intermediate-depth earthquakes from the International Seismic Centre, the Central American Seismic Center, and the temporary PASSCAL TUCAN array. Using this dataset, we invert for Vp, Vs, and hypocenters using a variable-mesh double-difference tomography algorithm. By observing low-Vp areas within the normally high-Vp slab, we identify portions of the slab that are likely to contain serpentinized mantle, and thus contribute to higher degrees of melting and higher volatile components observable in arc lavas.

PAROTID FLUID CORTISOL AND CORTISONE.

DTIC Science & Technology

Concentrations of parotid fluid cortisol and cortisone, and of plasma dialyzable cortisol, were measured in normal men before and 2 hours after...of 8.5 to 17.7 micrograms/100 ml. after ACTH treatment, and to 39.4 micrograms/100 ml. after administration of the estrogen. However, parotid fluid...the increase in total plasma cortisol (which was over twice as high after administration of estrogen as of ACTH). Thus parotid fluid corticosteroids

Study of blood flow in several benchmark micro-channels using a two-fluid approach.

PubMed

Wu, Wei-Tao; Yang, Fang; Antaki, James F; Aubry, Nadine; Massoudi, Mehrdad

2015-10-01

It is known that in a vessel whose characteristic dimension (e.g., its diameter) is in the range of 20 to 500 microns, blood behaves as a non-Newtonian fluid, exhibiting complex phenomena, such as shear-thinning, stress relaxation, and also multi-component behaviors, such as the Fahraeus effect, plasma-skimming, etc. For describing these non-Newtonian and multi-component characteristics of blood, using the framework of mixture theory, a two-fluid model is applied, where the plasma is treated as a Newtonian fluid and the red blood cells (RBCs) are treated as shear-thinning fluid. A computational fluid dynamic (CFD) simulation incorporating the constitutive model was implemented using OpenFOAM® in which benchmark problems including a sudden expansion and various driven slots and crevices were studied numerically. The numerical results exhibited good agreement with the experimental observations with respect to both the velocity field and the volume fraction distribution of RBCs.

Effects of 30 day simulated microgravity and recovery on fluid homeostasis and renal function in the rat

NASA Technical Reports Server (NTRS)

Tucker, Bryan J.; Mendonca, Margarida M.

1995-01-01

Transition from a normal gravitational environment to that of microgravity eventually results in decreased plasma and blood volumes, increasing with duration of exposure to microgravity. This loss of vascular fluid is presumably due to negative fluid and electrolyte balance and most likely contributes to the orthostatic intolerance associated with the return to gravity. The decrease in plasma volume is presumed to be a reflection of a concurrent decrease in extracellular fluid volume with maintenance of normal plasma-interstitial fluid balance. In addition, the specific alterations in renal function contributing to these changes in fluid and electrolyte homeostasis are potentially responding to neuro-humoral signals that are not consistent with systemic fluid volume status. We have previously demonstrated an early increase in both glomerular filtration rate and extracellular fluid volume and that this decreases towards control values by 7 days of simulated microgravity. However, longer duration studies relating these changes to plasma volume alterations and the response to return to orthostasis have not been fully addressed. Male Wistar rats were chronically cannulated, submitted to 30 days heat-down tilt (HDT) and followed for 7 days after return to orthostasis from HDT. Measurements of renal function and extracellular and blood volumes were performed in the awake rat.

Infrared trace element detection system

DOEpatents

Bien, F.; Bernstein, L.S.; Matthew, M.W.

1988-11-15

An infrared trace element detection system includes an optical cell into which the sample fluid to be examined is introduced and removed. Also introduced into the optical cell is a sample beam of infrared radiation in a first wavelength band which is significantly absorbed by the trace element and a second wavelength band which is not significantly absorbed by the trace element for passage through the optical cell through the sample fluid. The output intensities of the sample beam of radiation are selectively detected in the first and second wavelength bands. The intensities of a reference beam of the radiation are similarly detected in the first and second wavelength bands. The sensed output intensity of the sample beam in one of the first and second wavelength bands is normalized with respect to the other and similarly, the intensity of the reference beam of radiation in one of the first and second wavelength bands is normalized with respect to the other. The normalized sample beam intensity and normalized reference beam intensity are then compared to provide a signal from which the amount of trace element in the sample fluid can be determined. 11 figs.

Infrared trace element detection system

DOEpatents

Bien, Fritz; Bernstein, Lawrence S.; Matthew, Michael W.

1988-01-01

An infrared trace element detection system including an optical cell into which the sample fluid to be examined is introduced and removed. Also introduced into the optical cell is a sample beam of infrared radiation in a first wavelength band which is significantly absorbed by the trace element and a second wavelength band which is not significantly absorbed by the trace element for passage through the optical cell through the sample fluid. The output intensities of the sample beam of radiation are selectively detected in the first and second wavelength bands. The intensities of a reference beam of the radiation are similarly detected in the first and second wavelength bands. The sensed output intensity of the sample beam in one of the first and second wavelength bands is normalized with respect to the other and similarly, the intensity of the reference beam of radiation in one of the first and second wavelength bands is normalized with respect to the other. The normalized sample beam intensity and normalized reference beam intensity are then compared to provide a signal from which the amount of trace element in the sample fluid can be determined.

Method for directional hydraulic fracturing

DOEpatents

Swanson, David E.; Daly, Daniel W.

1994-01-01

A method for directional hydraulic fracturing using borehole seals to confine pressurized fluid in planar permeable regions, comprising: placing a sealant in the hole of a structure selected from geologic or cemented formations to fill the space between a permeable planar component and the geologic or cemented formation in the vicinity of the permeable planar component; making a hydraulic connection between the permeable planar component and a pump; permitting the sealant to cure and thereby provide both mechanical and hydraulic confinement to the permeable planar component; and pumping a fluid from the pump into the permeable planar component to internally pressurize the permeable planar component to initiate a fracture in the formation, the fracture being disposed in the same orientation as the permeable planar component.

Pre-seismic anomalous geomagnetic signature related to M8.3 earthquake occurred in Chile on September 16-th, 2015

NASA Astrophysics Data System (ADS)

Armand Stanica, Dragos, ,, Dr.; Stanica, Dumitru, ,, Dr.; Vladimirescu, Nicoleta

2016-04-01

In this paper, we retrospectively analyzed the geomagnetic data collected, via internet (www.intermagnet.com), on the interval 01 July-30 September 2015 at the observatories Easter Island (IMP) and Pilar (PIL), placed in Chile and Argentina, respectively, to emphasize a possible relationship between the pre-seismic anomalous behavior of the normalized function Bzn and M8.3 earthquake, that occurred in Offshore Coquimbo (Chile) on September 16-th, 2015. The daily mean distributions of the normalized function Bzn=Bz/Bperp (where Bz is vertical component of the geomagnetic field; Bperp is geomagnetic component perpendicular to the geoelectrical strike) and its standard deviation (STDEV) are performed in the ULF frequency range 0.001Hz to 0.0083Hz by using the FFT band-pass filter analysis. It was demonstrated that in pre-seismic conditions the Bzn has a significant enhancement due to the crustal electrical conductivity changes, possibly associated with the earthquake-induced rupture-processes and high-pressure fluid flow through the faulting system developed inside the foci and its neighboring area. After analyzing the anomalous values of the normalized function Bzn obtained at Easter Island and Pilar observatories, the second one taken as reference, we used a statistical analysis, based on a standardized random variable equation, to identify on 1-2 September 2015 a pre-seismic signature related to the M8.3 earthquake. The lead time was 14 days before the M8.3 earthquake occurrence. The final conclusion is that the proposed geomagnetic methodology might be used to provide suitable information for the extreme earthquake hazard assessment.

Thermal Components Boost Performance of HVAC Systems

NASA Technical Reports Server (NTRS)

2012-01-01

As the International Space Station (ISS) travels 17,500 miles per hour, normal is having a constant sensation of free-falling. Normal is no rain, but an extreme amount of shine.with temperatures reaching 250 F when facing the Sun. Thanks to a number of advanced control systems onboard the ISS, however, the interior of the station remains a cool, comfortable, normal environment where astronauts can live and work for extended periods of time. There are two main control systems on the ISS that make it possible for humans to survive in space: the Thermal Control System (TCS) and the Environmental Control and Life Support system. These intricate assemblies work together to supply water and oxygen, regulate temperature and pressure, maintain air quality, and manage waste. Through artificial means, these systems create a habitable environment for the space station s crew. The TCS constantly works to regulate the temperature not only for astronauts, but for the critical instruments and machines inside the spacecraft as well. To do its job, the TCS encompasses several components and systems both inside and outside of the ISS. Inside the spacecraft, a liquid heat-exchange process mechanically pumps fluids in closed-loop circuits to collect, transport, and reject heat. Outside the ISS, an external system circulates anhydrous ammonia to transport heat and cool equipment, and radiators release the heat into space. Over the years, NASA has worked with a variety of partners.public and private, national and international. to develop and refine the most complex thermal control systems ever built for spacecraft, including the one on the ISS.

Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume.

PubMed

Carmichael, Owen; Xie, Jing; Fletcher, Evan; Singh, Baljeet; DeCarli, Charles

2012-06-01

Hippocampal injury in the Alzheimer's disease (AD) pathological process is region-specific and magnetic resonance imaging (MRI)-based measures of localized hippocampus (HP) atrophy are known to detect region-specific changes associated with clinical AD, but it is unclear whether these measures provide information that is independent of that already provided by measures of total HP volume. Therefore, this study assessed the strength of association between localized HP atrophy measures and AD-related measures including cerebrospinal fluid (CSF) amyloid beta and tau concentrations, and cognitive performance, in statistical models that also included total HP volume as a covariate. A computational technique termed localized components analysis (LoCA) was used to identify 7 independent patterns of HP atrophy among 390 semiautomatically delineated HP from baseline magnetic resonance imaging of participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Among cognitively normal participants, multiple measures of localized HP atrophy were significantly associated with CSF amyloid concentration, while total HP volume was not. In addition, among all participants, localized HP atrophy measures and total HP volume were both independently and additively associated with CSF tau concentration, performance on numerous neuropsychological tests, and discrimination between normal, mild cognitive impairment (MCI), and AD clinical diagnostic groups. Together, these results suggest that regional measures of hippocampal atrophy provided by localized components analysis may be more sensitive than total HP volume to the effects of AD pathology burden among cognitively normal individuals and may provide information about HP regions whose deficits may have especially profound cognitive consequences throughout the AD clinical course. Copyright © 2012 Elsevier Inc. All rights reserved.

Tumor-derived exosomes and their role in cancer progression

PubMed Central

Whiteside, Theresa L

2017-01-01

Tumor cells actively produce, release and utilize exosomes to promote tumor growth. Mechanisms through which tumor-derived exosomes subserve the tumor are under intense investigation. These exosomes are information carriers, conveying molecular and genetic messages from tumor cells to normal or other abnormal cells residing at close or distant sites. Tumor-derived exosomes are found in all body fluids. Upon the contact with target cells, they alter phenotypic and functional attributes of recipients, reprogramming them into active contributors to angiogenesis, thrombosis, metastasis and immunosuppression. Exosomes produced by tumors carry cargos that in part mimic contents of parent cells and are of potential interest as non-invasive biomarkers of cancer. Their role in inhibiting the host antitumor responses and in mediating drug resistance is important for cancer therapy. Tumor-derived exosomes may interfere with cancer immunotherapy, but they also could serve as adjuvants and antigenic components of antitumor vaccines. Their biological roles in cancer development or progression as well as cancer therapy suggest that tumor-derived exosomes are critical components of oncogenic transformation. PMID:27117662

Propagation of second sound in a superfluid Fermi gas in the unitary limit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arahata, Emiko; Nikuni, Tetsuro

2009-10-15

We study sound propagation in a uniform superfluid gas of Fermi atoms in the unitary limit. The existence of normal and superfluid components leads to appearance of two sound modes in the collisional regime, referred to as first and second sounds. The second sound is of particular interest as it is a clear signal of a superfluid component. Using Landau's two-fluid hydrodynamic theory, we calculate hydrodynamic sound velocities and these weights in the density response function. The latter is used to calculate the response to a sudden modification of the external potential generating pulse propagation. The amplitude of a pulsemore » which is proportional to the weight in the response function is calculated, the basis of the approach of Nozieres and Schmitt-Rink for the BCS-BEC. We show that, in a superfluid Fermi gas at unitarity, the second-sound pulse is excited with an appreciate amplitude by density perturbations.« less

GPU computing with Kaczmarz’s and other iterative algorithms for linear systems

PubMed Central

Elble, Joseph M.; Sahinidis, Nikolaos V.; Vouzis, Panagiotis

2009-01-01

The graphics processing unit (GPU) is used to solve large linear systems derived from partial differential equations. The differential equations studied are strongly convection-dominated, of various sizes, and common to many fields, including computational fluid dynamics, heat transfer, and structural mechanics. The paper presents comparisons between GPU and CPU implementations of several well-known iterative methods, including Kaczmarz’s, Cimmino’s, component averaging, conjugate gradient normal residual (CGNR), symmetric successive overrelaxation-preconditioned conjugate gradient, and conjugate-gradient-accelerated component-averaged row projections (CARP-CG). Computations are preformed with dense as well as general banded systems. The results demonstrate that our GPU implementation outperforms CPU implementations of these algorithms, as well as previously studied parallel implementations on Linux clusters and shared memory systems. While the CGNR method had begun to fall out of favor for solving such problems, for the problems studied in this paper, the CGNR method implemented on the GPU performed better than the other methods, including a cluster implementation of the CARP-CG method. PMID:20526446

Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery.

PubMed

Dolor, Aaron; Szoka, Francis C

2018-06-04

Collagen and hyaluronan are the most abundant components of the extracellular matrix (ECM) and their overexpression in tumors is linked to increased tumor growth and metastasis. These ECM components contribute to a protective tumor microenvironment by supporting a high interstitial fluid pressure and creating a tortuous setting for the convection and diffusion of chemotherapeutic small molecules, antibodies, and nanoparticles in the tumor interstitial space. This review focuses on the research efforts to deplete extracellular collagen with collagenases to normalize the tumor microenvironment. Although collagen synthesis inhibitors are in clinical development, the use of collagenases is contentious and clinically untested in cancer patients. Pretreatment of murine tumors with collagenases increased drug uptake and diffusion 2-10-fold. This modest improvement resulted in decreased tumor growth, but the benefits of collagenase treatment are confounded by risks of toxicity from collagen breakdown in healthy tissues. In this review, we evaluate the published in vitro and in vivo benefits and limitations of collagenase treatment to improve drug delivery.

Development and Clinical Application of a New Method for the Radioimmunoassay of Arginine Vasopressin in Human Plasma

PubMed Central

Robertson, Gary L.; Mahr, Ermelinda A.; Athar, Shahid; Sinha, Tushar

1973-01-01

A radioimmunoassay has been developed that permits reliable measurements of plasma arginine vasopressin (AVP) at concentrations as low as 0.5 pg/ml in sample volumes of 1 ml or less. Nonhormonal immunoreactivity associated with the plasma proteins is eliminated by acetone precipitation before assay, leaving unaltered a component that is immunologically and chromatographically indistinguishable from standard AVP. Storage of plasma results in a decline in AVP concentration and, thus, must be carefully regulated. The plasma AVP values obtained by our method approximate the anticipated levels and vary in accordance with physiologic expections. In recumbent normal subjects, plasma AVP ranged from (mean ±SD) 5.4±3.4 pg/ml after fluid deprivation to 1.4±0.8 pg/ml after water loading, and correlated significantly with both plasma osmolality (r=0.52; P<0.001) and urine osmolality (r=0.77; P<0.001). After fluid restriction, plasma AVP was uniformly normal relative to plasma osmolality in patients with nephrogenic diabetes insipidus and primary polydipsia but was distinctly subnormal in all patients with pituitary diabetes insipidus. The infusion of physiologic amounts of posterior pituitary extract caused a dose-related rise in plasma vasopressin that afterwards declined at the expected rate (t½=22.5±4 min). We conclude that, when used appropriately, our radioimmunoassay method provides a useful way of assessing AVP function in man. PMID:4727463

Cell-derived microparticles and complement activation in preeclampsia versus normal pregnancy.

PubMed

Biró, E; Lok, C A R; Hack, C E; van der Post, J A M; Schaap, M C L; Sturk, A; Nieuwland, R

2007-01-01

Inflammation plays a major role in the vascular dysfunction seen in preeclampsia, and several studies suggest involvement of the complement system. To investigate whether complement activation on the surface of microparticles is increased in plasma of preeclamptic patients versus healthy pregnant controls. Microparticles from plasma of preeclamptic (n=10), healthy pregnant (n=10) and healthy nonpregnant (n=10) women were analyzed by flow cytometry for bound complement components (C1q, C4, C3) and complement activator molecules (C-reactive protein [CRP], serum amyloid P component [SAP], immunoglobulin [Ig]M, IgG). Fluid phase complement activation products and activator molecules were also determined. Levels of microparticles with bound complement components showed no increase in complement activation on the microparticle surface in preeclamptic women, in line with levels of fluid phase complement activation products. In healthy nonpregnant and pregnant women, bound CRP was associated with classical pathway activation on the microparticle surface, and in healthy pregnant women IgM and IgG molecules also contributed. In preeclamptic women, microparticles with bound SAP and those with IgG seemed to contribute to C1q binding without a clear association to further classical pathway activation. Furthermore, significantly increased levels of microparticles with bound CRP were present in preeclamptic compared with healthy pregnant women (median 178x10(6)/L versus 47x10(6)/L, P<0.01), but without concomitant increases in complement activation. We found no evidence of increased complement activation on the microparticle surface in preeclamptic women. Microparticles with bound CRP were significantly increased, but in contrast to healthy pregnant and nonpregnant women, this was not associated with increased classical pathway activation on the surface of the microparticles.

Biliary obstruction - slideshow

MedlinePlus

... ency/presentations/100199.htm Biliary obstruction - series—Normal anatomy To use the sharing ... Overview Bile is a digestive fluid secreted by the liver and stored in the gallbladder which normally is ...

Plant fluid proteomics: Delving into the xylem sap, phloem sap and apoplastic fluid proteomes

USDA-ARS?s Scientific Manuscript database

The phloem sap, xylem sap and apoplastic fluid play key roles in long and short distance transport of signals and nutrients, and act as a barrier against local and systemic pathogen infection. Among other components, these plant fluids contain proteins which are likely to be important players in the...

Plant fluid proteomics: Delving into the xylem sap, phloem sap and apoplastic fluid proteomes

USDA-ARS?s Scientific Manuscript database

The phloem sap, xylem sap and apoplastic fluid play key roles in long and short distance transport of signals and nutrients, and act as a barrier against local and systemic pathogen infection. Among other components, these plant fluids contain proteins, which are likely to be important players in th...

Regulation of intramembranous absorption and amniotic fluid volume by constituents in fetal sheep urine

PubMed Central

Jonker, Sonnet S.; Louey, Samantha; Cheung, Cecilia Y.; Brace, Robert A.

2013-01-01

Our objective was to test the hypothesis that fetal urine contains a substance(s) that regulates amniotic fluid volume by altering the rate of intramembranous absorption of amniotic fluid. In late gestation ovine fetuses, amniotic fluid volumes, urine, and lung liquid production rates, swallowed volumes and intramembranous volume and solute absorption rates were measured over 2-day periods under control conditions and when urine was removed and continuously replaced at an equal rate with exogenous fluid. Intramembranous volume absorption rate decreased by 40% when urine was replaced with lactated Ringer solution or lactated Ringer solution diluted 50% with water. Amniotic fluid volume doubled under both conditions. Analysis of the intramembranous sodium and chloride fluxes suggests that the active but not passive component of intramembranous volume absorption was altered by urine replacement, whereas both active and passive components of solute fluxes were altered. We conclude that fetal urine contains an unidentified substance(s) that stimulates active intramembranous transport of amniotic fluid across the amnion into the underlying fetal vasculature and thereby functions as a regulator of amniotic fluid volume. PMID:23824958

Working memory components that predict word problem solving: Is it merely a function of reading, calculation, and fluid intelligence?

PubMed

Fung, Wenson; Swanson, H Lee

2017-07-01

The purpose of this study was to assess whether the differential effects of working memory (WM) components (the central executive, phonological loop, and visual-spatial sketchpad) on math word problem-solving accuracy in children (N = 413, ages 6-10) are completely mediated by reading, calculation, and fluid intelligence. The results indicated that all three WM components predicted word problem solving in the nonmediated model, but only the storage component of WM yielded a significant direct path to word problem-solving accuracy in the fully mediated model. Fluid intelligence was found to moderate the relationship between WM and word problem solving, whereas reading, calculation, and related skills (naming speed, domain-specific knowledge) completely mediated the influence of the executive system on problem-solving accuracy. Our results are consistent with findings suggesting that storage eliminates the predictive contribution of executive WM to various measures Colom, Rebollo, Abad, & Shih (Memory & Cognition, 34: 158-171, 2006). The findings suggest that the storage component of WM, rather than the executive component, has a direct path to higher-order processing in children.

Research on the porous flow of the mechanism of viscous-elastic fluids displacing residual oil droplets in micro pores

NASA Astrophysics Data System (ADS)

Dong, Guanyu

2018-03-01

In order to analyze the microscopic stress field acting on residual oil droplets in micro pores, calculate its deformation, and explore the hydrodynamic mechanism of viscous-elastic fluids displacing oil droplets, the viscous-elastic fluid flow equations in micro pores are established by choosing the Upper Convected Maxwell constitutive equation; the numerical solutions of the flow field are obtained by volume control and Alternate Direction Implicit methods. From the above, the velocity field and microscopic stress field; the forces acting on residual oil droplets; the deformations of residual oil droplets by various viscous-elastic displacing fluids and at various Wiesenberg numbers are calculated and analyzed. The result demonstrated that both the normal stress and horizontal force acting on the residual oil droplets by viscous-elastic fluids are much larger compared to that of inelastic fluid; the distribution of normal stress changes abruptly; under the condition of the same pressure gradient in the system under investigation, the ratio of the horizontal forces acting on the residual oil droplets by different displacing fluids is about 1:8:20, which means that under the above conditions, the driving force on a oil droplet is 20 times higher for a viscous-elastic fluid compared to that of a Newtonian Fluid. The conclusions are supportive of the mechanism that viscous-elastic driving fluids can increase the Displacement Efficiency. This should be of help in designing new chemicals and selecting Enhanced Oil Recovery systems.

Two-component fluid membranes near repulsive walls: Linearized hydrodynamics of equilibrium and nonequilibrium states.

PubMed

Sankararaman, Sumithra; Menon, Gautam I; Sunil Kumar, P B

2002-09-01

We study the linearized hydrodynamics of a two-component fluid membrane near a repulsive wall, using a model that incorporates curvature-concentration coupling as well as hydrodynamic interactions. This model is a simplified version of a recently proposed one [J.-B. Manneville et al., Phys. Rev. E 64, 021908 (2001)] for nonequilibrium force centers embedded in fluid membranes, such as light-activated bacteriorhodopsin pumps incorporated in phospholipid egg phosphatidyl choline (EPC) bilayers. The pump-membrane system is modeled as an impermeable, two-component bilayer fluid membrane in the presence of an ambient solvent, in which one component, representing active pumps, is described in terms of force dipoles displaced with respect to the bilayer midpoint. We first discuss the case in which such pumps are rendered inactive, computing the mode structure in the bulk as well as the modification of hydrodynamic properties by the presence of a nearby wall. These results should apply, more generally, to equilibrium fluid membranes comprised of two components, in which the effects of curvature-concentration coupling are significant, above the threshold for phase separation. We then discuss the fluctuations and mode structure in the steady state of active two-component membranes near a repulsive wall. We find that proximity to the wall smoothens membrane height fluctuations in the stable regime, resulting in a logarithmic scaling of the roughness even for initially tensionless membranes. This explicitly nonequilibrium result is a consequence of the incorporation of curvature-concentration coupling in our hydrodynamic treatment. This result also indicates that earlier scaling arguments which obtained an increase in the roughness of active membranes near repulsive walls upon neglecting the role played by such couplings may need to be reevaluated.

Simplified thermodynamic functions for vapor-liquid phase separation and fountain effect pumps

NASA Technical Reports Server (NTRS)

Yuan, S. W. K.; Hepler, W. A.; Frederking, T. H. K.

1984-01-01

He-4 fluid handling devices near 2 K require novel components for non-Newtonian fluid transport in He II. Related sizing of devices has to be based on appropriate thermophysical property functions. The present paper presents simplified equilibrium state functions for porous media components which serve as vapor-liquid phase separators and fountain effect pumps.

Method and apparatus for thermal power generation

DOEpatents

Mangus, James D.

1979-01-01

A method and apparatus for power generation from a recirculating superheat-reheat circuit with multiple expansion stages which alleviates complex control systems and minimizes thermal cycling of system components, particularly the reheater. The invention includes preheating cold reheat fluid from the first expansion stage prior to its entering the reheater with fluid from the evaporator or drum component.

Composition and method for removing photoresist materials from electronic components

DOEpatents

Davenhall, Leisa B [Santa Fe, NM; Rubin, James B [Los Alamos, NM; Taylor, Craig M. V. [Jemez Springs, NM

2008-06-03

Composition and method for removing photoresist materials from electronic components. The composition is a mixture of at least one dense phase fluid and at least one dense phase fluid modifier. The method includes exposing a substrate to at least one pulse of the composition in a supercritical state to remove photoresist materials from the substrate.

Composition and method for removing photoresist materials from electronic components

DOEpatents

Davenhall, Leisa B.; Rubin, James B.; Taylor, Craig M.

2005-01-25

Composition and method for removing photoresist materials from electronic components. The composition is a mixture of at least one dense phase fluid and at least one dense phase fluid modifier. The method includes exposing a substrate to at least one pulse of the composition in a supercritical state to remove photoresist materials from the substrate.

Fluid forces on two circular cylinders in crossflow

NASA Astrophysics Data System (ADS)

Jendrzejczyk, J. A.; Chen, S. S.

1986-07-01

Fluid excitation forces are measured in a water loop for two circular cylinders arranged in tandem and normal to flow. The Strouhal number and fluctuating drag and lift coefficients for both cylinders are presented for various spacings and incoming flow conditions. The results show the effects of Reynolds number, pitch ratio, and upstream turbulence on the fluid excitation forces.

Mean electromotive force generated by asymmetric fluid flow near the surface of earth's outer core

NASA Astrophysics Data System (ADS)

Bhattacharyya, Archana

1992-10-01

The phi component of the mean electromotive force, (ETF) generated by asymmetric flow of fluid just beneath the core-mantle boundary (CMB), is obtained using a geomagnetic field model. This analysis is based on the supposition that the axisymmetric part of fluid flow beneath the CMB is tangentially geostrophic and toroidal. For all the epochs studied, the computed phi component is stronger in the Southern Hemisphere than that in the Northern Hemisphere. Assuming a linear relationship between (ETF) and the azimuthally averaged magnetic field (AAMF), the only nonzero off-diagonal components of the pseudotensor relating ETF to AAMF, are estimated as functions of colatitude, and the physical implications of the results are discussed.

Estimating Vibrational Powers Of Parts In Fluid Machinery

NASA Technical Reports Server (NTRS)

Harvey, S. A.; Kwok, L. C.

1995-01-01

In new method of estimating vibrational power associated with component of fluid-machinery system, physics of flow through (or in vicinity of) component regarded as governing vibrations. Devised to generate scaling estimates for design of new parts of rocket engines (e.g., pumps, combustors, nozzles) but applicable to terrestrial pumps, turbines, and other machinery in which turbulent flows and vibrations caused by such flows are significant. Validity of method depends on assumption that fluid flows quasi-steadily and that flow gives rise to uncorrelated acoustic powers in different parts of pump.

Pleural effusions and diseases of the pleura.

PubMed

Noone, K E

1985-09-01

There are four factors that govern fluid movement to or from the pleural space: hydrostatic pressure, colloid osmotic pressure, filtration coefficient, and lymphatic function. When any of these factors are altered, fluid accumulates within the pleural space. Congestive heart failure, pancreatitis, neoplasia, hypoalbuminemia, and pulmonary thromboembolism can evoke pleural effusions by altering normal fluid transport mechanisms. This approach to pleural effusion helps to explain fluid accumulation. Chylothorax, hemothorax, and empyema are also covered in the article.

Evaluation of nasal IgA secretion in normal subjects by nasal spray and aspiration.

PubMed

Fujimoto, Chisa; Kido, Hiroshi; Sawabuchi, Takako; Mizuno, Dai; Hayama, Masaki; Yanagawa, Hiroaki; Takeda, Noriaki

2009-06-01

Nasal washing (NW) is a popular method for collecting human nasal lavage fluid. However, for NW the subject must be trained, and the method is unsuitable for field studies on untrained subjects. To overcome this problem, we have developed an easy and painless method, a nasal spray and aspiration (NSA) method. This method is different from NW in that the nasal cavity is misted over with saline, and the nasal lavage fluid is aspirated from the nostrils through a silicon tube. First, nasal lavage fluid was obtained twice by NSA with an interval of a week between lavages to evaluate intraindividual variability, and the IgA and protein levels in the nasal lavage fluid were measured by enzyme-linked immunosorbent assay and bicinchoninic acid assay, respectively. Next, the IgA value determined by NSA was compared with that by NW in another 12 normal subjects 2 days after NSA. In 10 normal subjects, mean volume of saline sprayed into the nose was 0.46+/-0.15 ml (mean+/-S.D.). Mean volume of aspirated nasal lavage fluid containing both sprayed saline and nasal secretion was 0.44+/-0.37 ml. The mean IgA level/mg protein in the nasal lavage fluid determined by NSA was 112+/-18 microg/mg protein at the first and 99+/-20 at the second times of measurement, being highly reproducible. The mean value by NSA was 114+/-19 microg/mg protein, being almost the same as that by NW of 99+/-27. These findings suggest that the IgA level/mg protein in nasal lavage fluid determined by NSA instead of NW might be useful for assessing the variability of nasal IgA secretion.

Systemic complications of fluid resuscitation.

PubMed

Weinstein, P D; Doerfler, M E

1992-04-01

Fluid administration in critically ill individuals is frequently a major component of their therapy. There are important effects on blood pressure and maintenance of cardiac output and oxygen delivery, as detailed elsewhere in this text. There are also potentially negative side effects of this therapy, which have been less well defined. Edema of the gastrointestinal tract has been well described, primarily with crystalloid infusions. Gastrointestinal edema may have very complicated effects on albumin kinetics, fluid flux, and ion flux. It may lead to development of ileus. Increased nasogastric tube output may be incorrectly construed as unremitting obstruction rather than a result of the aforementioned changes and increased crystalloid loads. The relationships of intestinal edema to intestinal absorptive function and diarrhea are less clear. At present, changes in type of fluid infusion or correction of serum albumin level to normal cannot be uniformly recommended. The myocardium, although showing evidence of edema with crystalloid infusion, may appear to benefit from colloidal, osmotically active suspensions in the all too few studies that have been done. To date, there is no study giving evidence of clinically different outcome using a variety of fluids that cause, reduce, or prevent this edema. The presence or absence of myocardial edema may be important in patients who demonstrate decreased ventricular function during sepsis or other disorders in which aggressive fluid administration is routine. Edema of the skin has been associated primarily with decreased oxygen tension. Other studies have shown an association with impaired wound healing or increased risk of infection. A direct causal relationship can only be inferred. We are left with a sense that aggressive fluid resuscitation with crystalloid, although improving oxygen delivery, may have other deleterious effects on organ systems, such as the gastrointestinal tract, myocardium, and integument. The edema resulting from crystalloid administration may lessen or negate the benefits of increased oxygen delivery. Care needs to be taken in interpreting any alteration in organ function with respect to the fluid type and volume being administered. An alternative choice of therapy is lacking at present. The role of colloid has not been as well investigated as that of crystalloid and further study is warranted before any benefits become clear.

Tribological performance of the biological components of synovial fluid in artificial joint implants

NASA Astrophysics Data System (ADS)

Ghosh, Subir; Choudhury, Dipankar; Roy, Taposh; Moradi, Ali; Masjuki, H. H.; Pingguan-Murphy, Belinda

2015-08-01

The concentration of biological components of synovial fluid (such as albumin, globulin, hyaluronic acid, and lubricin) varies between healthy persons and osteoarthritis (OA) patients. The aim of the present study is to compare the effects of such variation on tribological performance in a simulated hip joint model. The study was carried out experimentally by utilizing a pin-on-disk simulator on ceramic-on-ceramic (CoC) and ceramic-on-polyethylene (CoP) hip joint implants. The experimental results show that both friction and wear of artificial joints fluctuate with the concentration level of biological components. Moreover, the performance also varies between material combinations. Wear debris sizes and shapes produced by ceramic and polyethylene were diverse. We conclude that the biological components of synovial fluid and their concentrations should be considered in order to select an artificial hip joint to best suit that patient.

The structure of a turbulent flow in a channel of complex shape

USGS Publications Warehouse

Tracy, Hubert Jerome

1976-01-01

Measurements of the Reynolds stresses and the mean motion pattern were made in a uniform turbulent motion in a conduit consisting of a large, nearly square section joined by a smaller rectangular section. The results indicate that the boundary shearing stress is nearly constant over large segments of the boundaries. The magnitudes of the lateral and the vertical components of turbulence are not the same near a boundary and the component normal to the boundary is smaller than the component parallel to the boundary. The difference in the two components in the corner regions of the channel produces secondary mean motions in the plane of the channel section. The strength of the motion depends upon the angle subtended by the corner. A principal function of the secondary motions is to transfer momentum into the corner regions and, elsewhere, to compensate for the excess force due to the shear gradients. In the absence of the secondary motions, the fluid must stagnate and separate from the boundaries in certain regions and be greatly accelerated in others. The secondary motions are conventionally described in terms of symmetrical rotations in cells bounded by the corner bisectors. The measured motion pattern is at variance with this view, unless the symmetry is confined to a very local region. (Woodard-USGS)

Use of Raman microscopy and multivariate data analysis to observe the biomimetic growth of carbonated hydroxyapatite on bioactive glass.

PubMed

Seah, Regina K H; Garland, Marc; Loo, Joachim S C; Widjaja, Effendi

2009-02-15

In the present contribution, the biomimetic growth of carbonated hydroxyapatite (HA) on bioactive glass were investigated by Raman microscopy. Bioactive glass samples were immersed in simulated body fluid (SBF) buffered solution at pH 7.40 up to 17 days at 37 degrees C. Raman microscopy mapping was performed on the bioglass samples immersed in SBF solution for different periods of time. The collected data was then analyzed using the band-target entropy minimization technique to extract the observable pure component Raman spectral information. In this study, the pure component Raman spectra of the precursor amorphous calcium phosphate, transient octacalcium phosphate, and matured HA were all recovered. In addition, pure component Raman spectra of calcite, silica glass, and some organic impurities were also recovered. The resolved pure component spectra were fit to the normalized measured Raman data to provide the spatial distribution of these species on the sample surfaces. The current results show that Raman microscopy and multivariate data analysis provide a sensitive and accurate tool to characterize the surface morphology, as well as to give more specific information on the chemical species present and the phase transformation of phosphate species during the formation of HA on bioactive glass.

The role of water in the petrogenesis of Marina trough magmas

NASA Astrophysics Data System (ADS)

Stolper, Edward; Newman, Sally

1994-02-01

Most variations in composition among primitive basalts from the Mariana back-arc trough can be explained by melting mixtures of an N-type mid-ocean ridge basalt (NMORB) mantle source and an H2O rich component, provided the degree of melting is positively and approximately linearly correlated with the proportion of the H2O-rich component in the mixture. We conclude that the degrees of melting by which Mariana trough magmas are generated increase from magmas similar to NMORB, through more H2O-enriched basalts, to 'arc-like' basalts, and that this increase is due to the lowering of the solidus of mantle peridotite that accompanies addition of the H2O-rich component. The H2O-rich component is likely to be ultimately derived from fluid from a subducting slab, but we propose that by the time fluids reach the source regions of Mariana trough basalts, they have interacted with sufficient mantle material that for all but the most incompatible of elements (with respect to fluid-mantle interaction), they are in equilibrium with the mantle. In contrast, fluids added to the source regions of Mariana island-arc magmas have typically interacted with less mantle and thus retain the signature of slab-derived fluids to varying degrees for all but the most compatible elements. Primitive Mariana arc basalts can be generated by melting mixtures of such incompletely exchanged slab-derived fluids and sources similar to NMORB-type mantle sources, but the degrees of melting are typically higher than those of Mariana trough NMORB and the sources have been variably depleted relative to the back-arc sources by previous melt extraction. This depletion may be related to earlier extraction of back-arc basin magmas or may evolve by repeated fluxing of the sources as fluid is continually added to them in the regions of arc magma generation. If fluid with partitioning behavior relative to the solid mantle similar to that deduced for the H2O-rich component involved in the generation of Mariana trough basalts were extracted from primitive mantle, the residual mantle would have many of the minor and trace element characteristics of typical oceanic upper mantle; primitive mantle enriched in such fluid would be a satisfactory source for the continental crust in terms of its trace and minor element chemical composition.

Removing inter-subject technical variability in magnetic resonance imaging studies.

PubMed

Fortin, Jean-Philippe; Sweeney, Elizabeth M; Muschelli, John; Crainiceanu, Ciprian M; Shinohara, Russell T

2016-05-15

Magnetic resonance imaging (MRI) intensities are acquired in arbitrary units, making scans non-comparable across sites and between subjects. Intensity normalization is a first step for the improvement of comparability of the images across subjects. However, we show that unwanted inter-scan variability associated with imaging site, scanner effect, and other technical artifacts is still present after standard intensity normalization in large multi-site neuroimaging studies. We propose RAVEL (Removal of Artificial Voxel Effect by Linear regression), a tool to remove residual technical variability after intensity normalization. As proposed by SVA and RUV [Leek and Storey, 2007, 2008, Gagnon-Bartsch and Speed, 2012], two batch effect correction tools largely used in genomics, we decompose the voxel intensities of images registered to a template into a biological component and an unwanted variation component. The unwanted variation component is estimated from a control region obtained from the cerebrospinal fluid (CSF), where intensities are known to be unassociated with disease status and other clinical covariates. We perform a singular value decomposition (SVD) of the control voxels to estimate factors of unwanted variation. We then estimate the unwanted factors using linear regression for every voxel of the brain and take the residuals as the RAVEL-corrected intensities. We assess the performance of RAVEL using T1-weighted (T1-w) images from more than 900 subjects with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as well as healthy controls from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We compare RAVEL to two intensity-normalization-only methods: histogram matching and White Stripe. We show that RAVEL performs best at improving the replicability of the brain regions that are empirically found to be most associated with AD, and that these regions are significantly more present in structures impacted by AD (hippocampus, amygdala, parahippocampal gyrus, enthorinal area, and fornix stria terminals). In addition, we show that the RAVEL-corrected intensities have the best performance in distinguishing between MCI subjects and healthy subjects using the mean hippocampal intensity (AUC=67%), a marked improvement compared to results from intensity normalization alone (AUC=63% and 59% for histogram matching and White Stripe, respectively). RAVEL is promising for many other imaging modalities. Published by Elsevier Inc.

A model of fluid and solute exchange in the human: validation and implications.

PubMed

Bert, J L; Gyenge, C C; Bowen, B D; Reed, R K; Lund, T

2000-11-01

In order to understand better the complex, dynamic behaviour of the redistribution and exchange of fluid and solutes administered to normal individuals or to those with acute hypovolemia, mathematical models are used in addition to direct experimental investigation. Initial validation of a model developed by our group involved data from animal experiments (Gyenge, C.C., Bowen, B.D., Reed, R.K. & Bert, J.L. 1999b. Am J Physiol 277 (Heart Circ Physiol 46), H1228-H1240). For a first validation involving humans, we compare the results of simulations with a wide range of different types of data from two experimental studies. These studies involved administration of normal saline or hypertonic saline with Dextran to both normal and 10% haemorrhaged subjects. We compared simulations with data including the dynamic changes in plasma and interstitial fluid volumes VPL and VIT respectively, plasma and interstitial colloid osmotic pressures PiPL and PiIT respectively, haematocrit (Hct), plasma solute concentrations and transcapillary flow rates. The model predictions were overall in very good agreement with the wide range of experimental results considered. Based on the conditions investigated, the model was also validated for humans. We used the model both to investigate mechanisms associated with the redistribution and transport of fluid and solutes administered following a mild haemorrhage and to speculate on the relationship between the timing and amount of fluid infusions and subsequent blood volume expansion.

High resolution pipette

DOEpatents

Beroz, Justin Douglas; Hart, Anastasios John

2016-06-07

A pipette includes a movable piston and a diaphragm that at least partly defines a fluid chamber enclosing a volume of working fluid. The piston displaces a volumetric amount of the working fluid in the chamber when moved. In response, the diaphragm displaces a smaller volumetric amount of fluid outside the chamber. A deamplification ratio is defined by the ratio of the volume displaced by the diaphragm to the volume displaced by the piston. The deamplification ratio is adjustable by adjusting or changing the diaphragm and/or by adjusting the size of the fluid chamber. The deamplifying pipette enables measuring and dispensing of very small volumes of liquid and is easily adapted to commercially available pipette components. Pipette components such as a pipette tip or adaptor may include a diaphragm to enable deamplification of the nominal volume capacity of a given pipette device.

The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic' system?

PubMed

Abbott, N Joan; Pizzo, Michelle E; Preston, Jane E; Janigro, Damir; Thorne, Robert G

2018-03-01

Brain fluids are rigidly regulated to provide stable environments for neuronal function, e.g., low K + , Ca 2+ , and protein to optimise signalling and minimise neurotoxicity. At the same time, neuronal and astroglial waste must be promptly removed. The interstitial fluid (ISF) of the brain tissue and the cerebrospinal fluid (CSF) bathing the CNS are integral to this homeostasis and the idea of a glia-lymph or 'glymphatic' system for waste clearance from brain has developed over the last 5 years. This links bulk (convective) flow of CSF into brain along the outside of penetrating arteries, glia-mediated convective transport of fluid and solutes through the brain extracellular space (ECS) involving the aquaporin-4 (AQP4) water channel, and finally delivery of fluid to venules for clearance along peri-venous spaces. However, recent evidence favours important amendments to the 'glymphatic' hypothesis, particularly concerning the role of glia and transfer of solutes within the ECS. This review discusses studies which question the role of AQP4 in ISF flow and the lack of evidence for its ability to transport solutes; summarizes attributes of brain ECS that strongly favour the diffusion of small and large molecules without ISF flow; discusses work on hydraulic conductivity and the nature of the extracellular matrix which may impede fluid movement; and reconsiders the roles of the perivascular space (PVS) in CSF-ISF exchange and drainage. We also consider the extent to which CSF-ISF exchange is possible and desirable, the impact of neuropathology on fluid drainage, and why using CSF as a proxy measure of brain components or drug delivery is problematic. We propose that new work and key historical studies both support the concept of a perivascular fluid system, whereby CSF enters the brain via PVS convective flow or dispersion along larger caliber arteries/arterioles, diffusion predominantly regulates CSF/ISF exchange at the level of the neurovascular unit associated with CNS microvessels, and, finally, a mixture of CSF/ISF/waste products is normally cleared along the PVS of venules/veins as well as other pathways; such a system may or may not constitute a true 'circulation', but, at the least, suggests a comprehensive re-evaluation of the previously proposed 'glymphatic' concepts in favour of a new system better taking into account basic cerebrovascular physiology and fluid transport considerations.

Fluid overpressure estimates from the aspect ratios of mineral veins

NASA Astrophysics Data System (ADS)

Philipp, Sonja L.

2012-12-01

Several hundred calcite veins and (mostly) normal faults were studied in limestone and shale layers of a Mesozoic sedimentary basin next to the village of Kilve at the Bristol Channel (SW-England). The veins strike mostly E-W (239 measurements), that is, parallel with the associated normal faults. The mean vein dip is 73°N (44 measurements). Field observations indicate that these faults transported the fluids up into the limestone layers. The vein outcrop (trace) length (0.025-10.3 m) and thickness (0.1-28 mm) size distributions are log-normal. Taking the thickness as the dependent variable and the outcrop length as the independent variable, linear regression gives a coefficient of determination (goodness of fit) of R2 = 0.74 (significant with 99% confidence), but natural logarithmic transformation of the thickness-length data increases the coefficient of determination to R2 = 0.98, indicating that nearly all the variation in thickness can be explained in terms of variation in trace length. The geometric mean of the aspect (length/thickness) ratio, 451, gives the best representation of the data set. With 95% confidence, the true geometric mean of the aspect ratios of the veins lies in the interval 409-497. Using elastic crack theory, appropriate elastic properties of the host rock, and the mean aspect ratio, the fluid overpressure (that is, the total fluid pressure minus the normal stress on the fracture plane) at the time of vein formation is estimated at around 18 MPa. From these results, and using the average host rock and water densities, the depth to the sources of the fluids (below the present exposures) forming the veins is estimated at between around 300 m and 1200 m. These results are in agreement to those obtained by independent isotopic studies and indicate that the fluids were of rather local origin, probably injected from sill-like sources (water sills) inside the sedimentary basin.

Osteoarthritis screening using Raman spectroscopy of dried human synovial fluid drops

NASA Astrophysics Data System (ADS)

Esmonde-White, Karen A.; Mandair, Gurjit S.; Esmonde-White, Francis W. L.; Raaii, Farhang; Roessler, Blake J.; Morris, Michael D.

2009-02-01

We describe the use of Raman spectroscopy to investigate synovial fluid drops deposited onto fused silica microscope slides. This spectral information can be used to identify chemical changes in synovial fluid associated with osteoarthritis (OA) damage to knee joints. The chemical composition of synovial fluid is predominately proteins (enzymes, cytokines, or collagen fragments), glycosaminoglycans, and a mixture of minor components such as inorganic phosphate crystals. During osteoarthritis, the chemical, viscoelastic and biological properties of synovial fluid are altered. A pilot study was conducted to determine if Raman spectra of synovial fluid correlated with radiological scoring of knee joint damage. After informed consent, synovial fluid was drawn and x-rays were collected from the knee joints of 40 patients. Raman spectra and microscope images were obtained from the dried synovial fluid drops using a Raman microprobe and indicate a coarse separation of synovial fluid components. Individual protein signatures could not be identified; Raman spectra were useful as a general marker of overall protein content and secondary structure. Band intensity ratios used to describe protein and glycosaminoglycan structure were used in synovial fluid spectra. Band intensity ratios of Raman spectra indicate that there is less ordered protein secondary structure in synovial fluid from the damage group. Combination of drop deposition with Raman spectroscopy is a powerful approach to examining synovial fluid for the purposes of assessing osteoarthritis damage.

Normally-Closed Zero-Leak Valve with Magnetostrictive Actuator

NASA Technical Reports Server (NTRS)

Ramspacher, Daniel J. (Inventor); Richard, James A. (Inventor)

2017-01-01

A non-pyrotechnic, normally-closed, zero-leak valve is a replacement for the pyrovalve used for both in-space and launch vehicle applications. The valve utilizes a magnetostrictive alloy for actuation, rather than pyrotechnic charges. The alloy, such as Terfenol-D, experiences magnetostriction, i.e. a gross elongation, when exposed to a magnetic field. This elongation fractures a parent metal seal, allowing fluid flow through the valve. The required magnetic field is generated by redundant coils that are isolated from the working fluid.

49 CFR 571.116 - Standard No. 116; Motor vehicle brake fluids.

Code of Federal Regulations, 2012 CFR

2012-10-01

... cavity or sac on the surface of a brake cup. Brake fluid means a liquid designed for use in a motor... designed for use in motor vehicle hydraulic brake systems in which the fluid is not in contact with... rubber components of brake systems designed for use with DOT brake fluids. (3) KEEP HYDRAULIC SYSTEM...

49 CFR 571.116 - Standard No. 116; Motor vehicle brake fluids.

Code of Federal Regulations, 2013 CFR

2013-10-01

... cavity or sac on the surface of a brake cup. Brake fluid means a liquid designed for use in a motor... designed for use in motor vehicle hydraulic brake systems in which the fluid is not in contact with... rubber components of brake systems designed for use with DOT brake fluids. (3) KEEP HYDRAULIC SYSTEM...

49 CFR 571.116 - Standard No. 116; Motor vehicle brake fluids.

Code of Federal Regulations, 2014 CFR

2014-10-01

... cavity or sac on the surface of a brake cup. Brake fluid means a liquid designed for use in a motor... designed for use in motor vehicle hydraulic brake systems in which the fluid is not in contact with... rubber components of brake systems designed for use with DOT brake fluids. (3) KEEP HYDRAULIC SYSTEM...

Reference Fluid Thermodynamic and Transport Properties Database (REFPROP)

National Institute of Standards and Technology Data Gateway

SRD 23 NIST Reference Fluid Thermodynamic and Transport Properties Database (REFPROP) (PC database for purchase)   NIST 23 contains revised data in a Windows version of the database, including 105 pure fluids and allowing mixtures of up to 20 components. The fluids include the environmentally acceptable HFCs, traditional HFCs and CFCs and 'natural' refrigerants like ammonia

46 CFR 58.30-20 - Fluid power hose and fittings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MACHINERY AND RELATED SYSTEMS Fluid Power and Control Systems § 58.30-20 Fluid power hose and fittings. (a... 46 Shipping 2 2012-10-01 2012-10-01 false Fluid power hose and fittings. 58.30-20 Section 58.30-20... of flexible hose where required for proper operation of machinery and components in the hydraulic...

46 CFR 58.30-20 - Fluid power hose and fittings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MACHINERY AND RELATED SYSTEMS Fluid Power and Control Systems § 58.30-20 Fluid power hose and fittings. (a... 46 Shipping 2 2011-10-01 2011-10-01 false Fluid power hose and fittings. 58.30-20 Section 58.30-20... of flexible hose where required for proper operation of machinery and components in the hydraulic...

46 CFR 58.30-20 - Fluid power hose and fittings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MACHINERY AND RELATED SYSTEMS Fluid Power and Control Systems § 58.30-20 Fluid power hose and fittings. (a... 46 Shipping 2 2013-10-01 2013-10-01 false Fluid power hose and fittings. 58.30-20 Section 58.30-20... of flexible hose where required for proper operation of machinery and components in the hydraulic...

Evidence for a nonmagmatic component in potassic hydrothermal fluids of porphyry cu-Au-Mo systems, Yukon, Canada

NASA Astrophysics Data System (ADS)

Selby, David; Nesbitt, Bruce E.; Creaser, Robert A.; Reynolds, Peter H.; Muehlenbachs, Karlis

2001-02-01

Isotopic (H, Sr, Pb, Ar) and fluid inclusion data for hydrothermal fluids associated with potassic alteration from three Late Cretaceous porphyry Cu occurrences, west central Yukon, suggest a nonmagmatic fluid component was present in these hydrothermal fluids. Potassic stage quartz veins contain a dominant assemblage of saline and vapor-rich fluid inclusions that have δD values between -120 and -180‰. Phyllic stage quartz veins are dominated by vapor-rich fluid inclusions and have δD values that overlap with but are, on average, heavier (-117 to -132‰) than those in potassic stage quartz veins. These δD values are significantly lower than those from plutonic quartz phenocrysts (-91 to -113‰), and from values typically reported for primary fluids from porphyry-style mineralization (-40 to -100‰). The initial Sr ( 87Sr/ 86Sr i) isotopic values for the plutons are 0.7055 (Casino), 0.7048 (Mt. Nansen), and 0.7055 (Cash). The 87Sr/ 86Sr i compositions of hydrothermal K-feldspar ranges from magmatic Sr i values to more radiogenic compositions (Casino: 0.70551-0.70834, n = 8; Mt. Nansen: 0.7063-0.7070, n = 4; Cash: 0.7058, n = 1). The fluid inclusion waters from potassic quartz veins have 87Sr/ 86Sr i values that are similar to those of co-existing hydrothermal K-feldspar. The Pb isotopic compositions of hydrothermal K-feldspar show a weak positive correlation with Sr i for identical samples. Fluid inclusion waters of phyllic quartz veins also have Sr i compositions more radiogenic than the plutons. The Pb isotopic composition of pyrite and bornite from phyllic alteration veins are similar to, or more radiogenic than, hydrothermal K-feldspar Pb isotopic values. Hydrothermal K-feldspar samples yield 40Ar/ 39Ar ages (Casino = 71.9 ± 0.7 to 73.4 ± 0.8 Ma; Mt. Nansen = 68.2 ± 0.7 and 69.5 ± 0.6 Ma; Cash = 68.3 ± 0.8 Ma) similar to the U-Pb zircon, K-Ar biotite and Re-Os molybdenite ages of the Late Cretaceous plutons, with the age spectra indicating no excess 40Ar or disturbance. The 40Ar/ 36Ar values (285-292) of the K-feldspar samples are similar to the atmospheric compositions (295 ± 5) during Late Cretaceous time. The H, Sr, Pb, and Ar isotopic compositions of hydrothermal K-feldspar and quartz vein fluid inclusion waters that characterize the potassic hydrothermal fluids show evidence for an exotic component in addition to magmatic water (fluid). This component has a low δD, radiogenic Sr and Pb, and an atmospheric Ar composition. The inheritance of pre-existing isotope compositions from the host rocks, postpotassic alteration isotope exchange, or the replenishment of the magma chamber with magma of different isotopic composition cannot explain the isotope data. We suggest that to generate the observed H, Sr, Pb, and Ar isotope compositions, crustal fluids must be a component (15-94%) of potassic hydrothermal fluids in porphyry mineralization in the deposits studied.

Fault zone architecture of a major oblique-slip fault in the Rawil depression, Western Helvetic nappes, Switzerland

NASA Astrophysics Data System (ADS)

Gasser, D.; Mancktelow, N. S.

2009-04-01

The Helvetic nappes in the Swiss Alps form a classic fold-and-thrust belt related to overall NNW-directed transport. In western Switzerland, the plunge of nappe fold axes and the regional distribution of units define a broad depression, the Rawil depression, between the culminations of Aiguilles Rouge massif to the SW and Aar massif to the NE. A compilation of data from the literature establishes that, in addition to thrusts related to nappe stacking, the Rawil depression is cross-cut by four sets of brittle faults: (1) SW-NE striking normal faults that strike parallel to the regional fold axis trend, (2) NW-SE striking normal faults and joints that strike perpendicular to the regional fold axis trend, and (3) WNW-ESE striking normal plus dextral oblique-slip faults as well as (4) WSW-ENE striking normal plus dextral oblique-slip faults that both strike oblique to the regional fold axis trend. We studied in detail a beautifully exposed fault from set 3, the Rezli fault zone (RFZ) in the central Wildhorn nappe. The RFZ is a shallow to moderately-dipping (ca. 30-60˚) fault zone with an oblique-slip displacement vector, combining both dextral and normal components. It must have formed in approximately this orientation, because the local orientation of fold axes corresponds to the regional one, as does the generally vertical orientation of extensional joints and veins associated with the regional fault set 2. The fault zone crosscuts four different lithologies: limestone, intercalated marl and limestone, marl and sandstone, and it has a maximum horizontal dextral offset component of ~300 m and a maximum vertical normal offset component of ~200 m. Its internal architecture strongly depends on the lithology in which it developed. In the limestone, it consists of veins, stylolites, cataclasites and cemented gouge, in the intercalated marls and limestones of anastomosing shear zones, brittle fractures, veins and folds, in the marls of anastomosing shear zones, pressure solution seams and veins and in the sandstones of coarse breccia and veins. Later, straight, sharp fault planes cross-cut all these features. In all lithologies, common veins and calcite-cemented fault rocks indicate the strong involvement of fluids during faulting. Today, the southern Rawil depression and the Rhone Valley belong to one of the seismically most active regions in Switzerland. Seismogenic faults interpreted from earthquake focal mechanisms strike ENE-WSW to WNW-ESE, with dominant dextral strike-slip and minor normal components and epicentres at depths of < 15 km. All three Neogene fault sets (2-4) could have been active under the current stress field inferred from the current seismicity. This implies that the same mechanisms that formed these fault zones in the past may still persist at depth. The Rezli fault zone allows the detailed study of a fossil fault zone that can act as a model for processes still occurring at deeper levels in this seismically active region.

Albumin heterogeneity in low-abundance fluids. The case of urine and cerebro-spinal fluid.

PubMed

Bruschi, Maurizio; Santucci, Laura; Candiano, Giovanni; Ghiggeri, Gian Marco

2013-12-01

Serum albumin is a micro-heterogeneous protein composed of at least 40 isoforms. Its heterogeneity is even more pronounced in biological fluids other than serum, the major being urine and cerebrospinal fluid. Modification 'in situ' and/or selectivity of biological barriers, such as in the kidney, determines the final composition of albumin and may help in definition of inflammatory states. This review focuses on various aspects of albumin heterogeneity in low 'abundance fluids' and highlights the potential source of information in diseases. The electrical charge of the protein in urine and CSF is modified but with an opposite change and depending on clinical conditions. In normal urine, the bulk of albumin is more anionic than in serum for the presence of ten times more fatty acids that introduce equivalent anionic charges and modify hydrophobicity of the protein. At the same time, urinary albumin is more glycosylated compared to the serum homolog. Finally, albumin fragments can be detected in urine in patients with proteinuria. For albumin in CSF, we lack information relative to normal conditions since ethical problems do not allow normal CSF to be studied. In multiple sclerosis, the albumin charge in CSF is more cationic than in serum, this change possibly involving structural anomalies or small molecules bindings. Massively fatty albumin could be toxic for tubular cells and be eliminated on this basis. Renal handling of glycosylated albumin can alter the normal equilibrium of filtration/reabsorption and trigger mechanisms leading to glomerulosclerosis and tubulo-interstitial fibrosis. This article is part of a Special Issue entitled Serum Albumin. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

On Kinetic Slow Modes, Fluid Slow Modes, and Pressure-balanced Structures in the Solar Wind

DOE Office of Scientific and Technical Information (OSTI.GOV)

Verscharen, Daniel; Chen, Christopher H. K.; Wicks, Robert T., E-mail: daniel.verscharen@unh.edu, E-mail: christopher.chen@imperial.ac.uk, E-mail: r.wicks@ucl.ac.uk

Observations in the solar wind suggest that the compressive component of inertial-range solar-wind turbulence is dominated by slow modes. The low collisionality of the solar wind allows for nonthermal features to survive, which suggests the requirement of a kinetic plasma description. The least-damped kinetic slow mode is associated with the ion-acoustic (IA) wave and a nonpropagating (NP) mode. We derive analytical expressions for the IA-wave dispersion relation in an anisotropic plasma in the framework of gyrokinetics and then compare them to fully kinetic numerical calculations, results from two-fluid theory, and magnetohydrodynamics (MHD). This comparison shows major discrepancies in the predictedmore » wave phase speeds from MHD and kinetic theory at moderate to high β . MHD and kinetic theory also dictate that all plasma normal modes exhibit a unique signature in terms of their polarization. We quantify the relative amplitude of fluctuations in the three lowest particle velocity moments associated with IA and NP modes in the gyrokinetic limit and compare these predictions with MHD results and in situ observations of the solar-wind turbulence. The agreement between the observations of the wave polarization and our MHD predictions is better than the kinetic predictions, which suggests that the plasma behaves more like a fluid in the solar wind than expected.« less

A FSI-based structural approach for micromechanical characterization of adipose tissue

NASA Astrophysics Data System (ADS)

Seyfi, Behzad; Sabzalinejad, Masoumeh; Haddad, Seyed M. H.; Fatouraee, Nasser; Samani, Abbas

2017-03-01

This paper presents a novel computational method for micromechanical modeling of adipose tissue. The model can be regarded as the first step for developing an inversion based framework that uses adipose stiffness data obtained from elastography to determine its microstructural alterations. Such information can be used as biomarkers for diseases associated with adipose tissue microstructure alteration (e.g. adipose tissue fibrosis and inflammation in obesity). In contrast to previous studies, the presented model follows a multiphase structure which accounts for both solid and fluid components as well as their mechanical interaction. In the model, the lipid droplets and extracellular matrix were considered as the fluid and solid phase, respectively. As such, the fluid-structure interaction (FSI) problem was solved using finite element method. In order to gain insight into how microstructural characteristics influence the macro scale mechanical properties of the adipose tissue, a compression mechanical test was simulated using the FSI model and its results were fitted to corresponding experimental data. The simulation procedure was performed for adipocytes in healthy conditions while the stiffness of extracellular matrix in normal adipose tissue was found by varying it systematically within an optimization process until the simulation response agreed with experimental data. Results obtained in this study are encouraging and show the capability of the proposed model to capture adipose tissue macroscale mechanical behavior based on its microstructure under health and different pathological conditions.

A depth-averaged debris-flow model that includes the effects of evolving dilatancy. I. physical basis

USGS Publications Warehouse

Iverson, Richard M.; George, David L.

2014-01-01

To simulate debris-flow behaviour from initiation to deposition, we derive a depth-averaged, two-phase model that combines concepts of critical-state soil mechanics, grain-flow mechanics and fluid mechanics. The model's balance equations describe coupled evolution of the solid volume fraction, m, basal pore-fluid pressure, flow thickness and two components of flow velocity. Basal friction is evaluated using a generalized Coulomb rule, and fluid motion is evaluated in a frame of reference that translates with the velocity of the granular phase, vs. Source terms in each of the depth-averaged balance equations account for the influence of the granular dilation rate, defined as the depth integral of ∇⋅vs. Calculation of the dilation rate involves the effects of an elastic compressibility and an inelastic dilatancy angle proportional to m−meq, where meq is the value of m in equilibrium with the ambient stress state and flow rate. Normalization of the model equations shows that predicted debris-flow behaviour depends principally on the initial value of m−meq and on the ratio of two fundamental timescales. One of these timescales governs downslope debris-flow motion, and the other governs pore-pressure relaxation that modifies Coulomb friction and regulates evolution of m. A companion paper presents a suite of model predictions and tests.

An approach for evaluating the respiratory irritation of mixtures: application to metalworking fluids.

PubMed

Schaper, M M; Detwiler-Okabayashi, K A

1995-01-01

Recently, the sensory and pulmonary irritating properties of ten metalworking fluids (MWF) were assessed using a mouse bioassay. Relative potency of the MWFs was estimated, but it was not possible to identify the component(s) responsible for the the respiratory irritation induced by each MWF. One of the ten fluids, MWF "ET", produced sensory and pulmonary irritation in mice, and it was of moderate potency in comparison to the other nine MWFs. MWF "E" had three major components: tall oil fatty acids (TOFA), sodium sulfonate (SA), and paraffinic oil (PO). In the present study, the sensory and pulmonary irritating properties of these individual components of MWF "E" were evaluated. Mixtures of the three components were also prepared and similarly evaluated. This analysis revealed that the sensory irritation from MWF "E" was largely due to TOFA, whereas SA produced the pulmonary irritation observed with MWF "E". Both TOFA and SA were more potent irritants than was MWF "E", and the potency of TOFA and/or SA was diminished through combination with PO. There was no evidence of synergism of the components when combined to form MWF "E". This approach for identifying the biologically "active" component(s) in a mixture should be useful for other MWFs. Furthermore, the approach should be easily adapted for other applications involving concerns with mixtures.

Laboratory Investigation of Rheology and Infiltration Process of Non-Newtonian Fluids through Porous Media in a Non-Isothermal Flow Regime for Effective Remediation of Contaminants

NASA Astrophysics Data System (ADS)

Naseer, F.

2017-12-01

Contamination of soil and groundwater by adsorbent (persistent) contaminants have been a major concern. Mine tailings, Acid mine drainage, waste disposal areas, active or abandoned surface and underground mines are some major causes of soil and water contamination. It is need of the hour to develop cost effective and efficient remediation techniques for clean-up of soil and aquifers. The objective of this research is to study a methodology of using non-Newtonian fluids for effective remediation of adsorbent contaminants in porous media under non-isothermal flow regimes. The research comprises of three components. Since, non-Newtonian fluid rheology has not been well studied in cold temperatures, the first component of the objective is to expose a non-Newtonian fluid (Guar gum solution) to different temperatures ranging from 30 °C through -5 °C to understand the change in viscosity, shear strength and contact angle of the fluid. Study of the flow characteristic of non-Newtonian fluids in complex porous media has been limited. Hence, the second component of this study will focus on a comparison of flow characteristics of a Newtonian fluid, non-Newtonian fluid and a combination of both fluids in a glass-tube-bundle setup that will act as a synthetic porous media. The study of flow characteristics will also be done for different thermal regimes ranging from -5 °C to 30 °C. The third component of the research will be to compare the effectiveness Guar gum to remediate a surrogate adsorbed contaminant at a certain temperature from the synthetic porous media. Guar gum is biodegradable and hence it is benign to the environment. Through these experiments, the mobility and behavior of Guar gum under varying temperature ranges will be characterized and its effectiveness in removing contaminants from soils will be understood. The impact of temperature change on the fluid and flow stability in the porous medium will be examined in this research. Guar gum is good suspension fluid and hence, studying the suspension capability below the freezing point would be of great importance. The outcome of this research will provide critical knowledge of cost-effective, environmentally benign and time efficient remediation of contaminated mine sites in Alaska and other cold regions.

Martian fluid and Martian weathering signatures identified in Nakhla, NWA 998 and MIL 03346 by halogen and noble gas analysis

NASA Astrophysics Data System (ADS)

Cartwright, J. A.; Gilmour, J. D.; Burgess, R.

2013-03-01

We report argon (Ar) noble gas, Ar-Ar ages and halogen abundances (Cl, Br, I) of Martian nakhlites Nakhla, NWA 998 and MIL 03346 to determine the presence of Martian hydrous fluids and weathering products. Neutron-irradiated samples were either crushed and step-heated (Nakhla only), or simply step-heated using a laser or furnace, and analysed for noble gases using an extension of the 40Ar-39Ar technique to determine halogen abundances. The data obtained provide the first isotopic evidence for a trapped fluid that is Cl-rich, has a strong correlation with 40ArXS (40ArXS = 40Armeasured - 40Arradiogenic) and displays 40ArXS/36Ar of ˜1000 - consistent with the Martian atmosphere. This component was released predominantly in the low temperature and crush experiments, which may suggest a fluid inclusion host. For the halogens, we observe similar Br/Cl and I/Cl ratios between the nakhlites and terrestrial reservoirs, which is surprising given the absence of crustal recycling, organic matter and frequent fluid activity on Mars. In particular, Br/Cl ratios in our Nakhla samples (especially olivine) are consistent with previously analysed Martian weathering products, and both low temperature and crush analyses show a similar trend to the evaporation of seawater. This may indicate that surface brines play an important role on Mars and on halogen assemblages within Martian meteorites and rocks. Elevated I/Cl ratios in the low temperature NWA 998 and MIL 03346 releases may relate to in situ terrestrial contamination, though we are unable to distinguish between low temperature terrestrial or Martian components. Whilst estimates of the amount of water present based on the 36Ar concentrations are too high to be explained by a fluid component alone, they are consistent with a mixed-phase inclusion (gas and fluid) or with shock-implanted Martian atmospheric argon. The observed fluid is dilute (low salinity, but high Br/Cl and I/Cl ratios), contains a Martian atmospheric component, and may represent a mixture of a shallow fluid with one derived from fluid circulation within the nakhlite cumulate pile - with heat for fluid circulation supplied by either the igneous intrusion or by an impact event.

Vapor-Gas Bubble Evolution and Growth in Extremely Viscous Fluids Under Vacuum

NASA Technical Reports Server (NTRS)

Kizito, John; Balasubramaniam, R.; Nahra, Henry; Agui, Juan; Truong, Duc

2008-01-01

Formation of vapor and gas bubbles and voids is normal and expected in flow processes involving extremely viscous fluids in normal gravity. Practical examples of extremely viscous fluids are epoxy-like filler materials before the epoxy fluids cure to their permanent form to create a mechanical bond between two substrates. When these fluids flow with a free liquid interface exposed to vacuum, rapid bubble expansion process may ensue. Bubble expansion might compromise the mechanical bond strength. The potential sources for the origin of the gases might be incomplete out-gassing process prior to filler application; regasification due to seal leakage in the filler applicator; and/or volatiles evolved from cure reaction products formed in the hardening process. We embarked on a study that involved conducting laboratory experiments with imaging diagnostics in order to deduce the seriousness of bubbling caused by entrained air and volatile fluids under space vacuum and low gravity environment. We used clear fluids with the similar physical properties as the epoxy-like filler material to mimic the dynamics of bubbles. Another aspect of the present study was to determine the likelihood of bubbling resulting from dissolved gases nucleating from solution. These experimental studies of the bubble expansion are compared with predictions using a modified Rayleigh- Plesset equation, which models the bubble expansion.

Supercritical Fluid Chromatography/Fourier Transform Infrared Spectroscopy Of Food Components

NASA Astrophysics Data System (ADS)

Calvey, Elizabeth M.; Page, Samuel W.; Taylor, Larry T.

1989-12-01

Supercritical fluid (SF) technologies are being investigated extensively for applications in food processing. The number of SF-related patents issued testifies to the level of interest. Among the properties of materials at temperatures and pressures above their critical points (supercritical fluids) is density-dependent solvating power. Supercritical CO2 is of particular interest to the food industry because of its low critical temperature (31.3°C) and low toxicity. Many of the components in food matrices react or degrade at elevated temperatures and may be adversely affected by high temperature extractions. Likewise, these components may not be amenable to GC analyses. Our SF research has been in the development of methods employing supercritical fluid chromatography (SFC) and extraction (SFE) coupled to a Fourier transform infrared (FT-IR) spectrometer to investigate food composition. The effects of processing techniques on the isomeric fatty acid content of edible oils and the analysis of lipid oxidation products using SFC/FT-IR with a flow-cell interface are described.

Intravenous Fluid Generation System

NASA Technical Reports Server (NTRS)

McQuillen, John; McKay, Terri; Brown, Daniel; Zoldak, John

2013-01-01

The ability to stabilize and treat patients on exploration missions will depend on access to needed consumables. Intravenous (IV) fluids have been identified as required consumables. A review of the Space Medicine Exploration Medical Condition List (SMEMCL) lists over 400 medical conditions that could present and require treatment during ISS missions. The Intravenous Fluid Generation System (IVGEN) technology provides the scalable capability to generate IV fluids from indigenous water supplies. It meets USP (U.S. Pharmacopeia) standards. This capability was performed using potable water from the ISS; water from more extreme environments would need preconditioning. The key advantage is the ability to filter mass and volume, providing the equivalent amount of IV fluid: this is critical for remote operations or resource- poor environments. The IVGEN technology purifies drinking water, mixes it with salt, and transfers it to a suitable bag to deliver a sterile normal saline solution. Operational constraints such as mass limitations and lack of refrigeration may limit the type and volume of such fluids that can be carried onboard the spacecraft. In addition, most medical fluids have a shelf life that is shorter than some mission durations. Consequently, the objective of the IVGEN experiment was to develop, design, and validate the necessary methodology to purify spacecraft potable water into a normal saline solution, thus reducing the amount of IV fluids that are included in the launch manifest. As currently conceived, an IVGEN system for a space exploration mission would consist of an accumulator, a purifier, a mixing assembly, a salt bag, and a sterile bag. The accumulator is used to transfer a measured amount of drinking water from the spacecraft to the purifier. The purifier uses filters to separate any air bubbles that may have gotten trapped during the drinking water transfer from flowing through a high-quality deionizing cartridge that removes the impurities in the water before entering the salt bag and mixing with the salt to create a normal saline solution.

CSF total protein

MedlinePlus

CSF total protein is a test to determine the amount of protein in your spinal fluid, also called cerebrospinal fluid (CSF). ... The normal protein range varies from lab to lab, but is typically about 15 to 60 milligrams per deciliter (mg/dL) ...

Direct numerical simulation of particle alignment in viscoelastic fluids

NASA Astrophysics Data System (ADS)

Hulsen, Martien; Jaensson, Nick; Anderson, Patrick

2016-11-01

Rigid particles suspended in viscoelastic fluids under shear can align in string-like structures in flow direction. To unravel this phenomenon, we present 3D direct numerical simulations of the alignment of two and three rigid, non-Brownian particles in a shear flow of a viscoelastic fluid. The equations are solved on moving, boundary-fitted meshes, which are locally refined to accurately describe the polymer stresses around and in between the particles. A small minimal gap size between the particles is introduced. The Giesekus model is used and the effect of the Weissenberg number, shear thinning and solvent viscosity is investigated. Alignment of two and three particles is observed. Morphology plots have been created for various combinations of fluid parameters. Alignment is mainly governed by the value of the elasticity parameter S, defined as half of the ratio between the first normal stress difference and shear stress of the suspending fluid. Alignment appears to occur above a critical value of S, which decreases with increasing shear thinning. This result, together with simulations of a shear-thinning Carreau fluid, leads us to the conclusion that normal stress differences are essential for particle alignment to occur, but it is also strongly promoted by shear thinning.

Effects of a novel palatinose based enteral formula (MHN-01) carbohydrate-adjusted fluid diet in improving the metabolism of carbohydrates and lipids in patients with esophageal cancer complicated by diabetes mellitus.

PubMed

Fujiwara, Toshiya; Naomoto, Yoshio; Motoki, Takayuki; Shigemitsu, Kaori; Shirakawa, Yasuhiro; Yamatsuji, Tomoki; Kataoka, Masafumi; Haisa, Minoru; Fujiwara, Toshiyoshi; Egi, Maritoki; Morimatsu, Hiroshi; Hanazaki, Motohiko; Katayama, Hiroshi; Morita, Kiyoshi; Mizumoto, Kenji; Asou, Takanobu; Arima, Hirofumi; Sasaki, Hajime; Matsuura, Motoi; Gunduz, Mehmet; Tanaka, Noriaki

2007-04-01

During perioperative management of patients with gastrointestinal cancer complicated by diabetes mellitus, adequate alimentation is required, but we often face difficulties associated with hyperglycemia and other accompanying complications. Recently, we investigated the effects of a novel palatinose based enteral formula (MHN-01) in suppressing post-prandial hyperglycemia and improving lipid metabolism in experimental animals and perioperative management of patients with esophageal cancer complicated by diabetes mellitus. We gave normal rats and rats with type 2 diabetes mellitus a single oral dose of fluid diet, and analyzed comparatively the time course of blood glucose level in each group until 3 h after the dose. In both the normal rat group and the type 2 diabetes group, peak blood glucose level after the MHN-01 dose was significantly lower than after a dose of ordinary fluid diet and was comparable to the peak level after a dose of a fluid diet rich in MUFA (monounsaturated fatty acid). We allowed normal mice free access to fluid diet for 43 days, and measured their body fat levels. Fat accumulation was significantly lower in mice given MHN-01 than in mice given ordinary fluid diet. We also analyzed the respiratory quotient and resting energy expenditure of normal Sprague-Dawley rats fed by MHN-01 or an ordinary fluid diet. The respiratory quotient of the MHN-01 group was significantly lower than the ordinary fluid group, although the resting energy expenditure of both groups was almost the same level. The effect of MHN-01 was estimated to be based on improvement of lipid metabolism. Between 2003 and 2005, among 164 patients who underwent radical thoracic esophagectomy and/or reconstruction for esophageal carcinoma at Okayama University Hospital, nine patients (5.5%) were diagnosed with diabetes mellitus in pre-operative screening and were treated with MHN-01. Clinical courses of two cases with severe status of diabetes mellitus were presented as successful case reports of MHN-01. MHN-01 was very useful in perioperative management of patients complicated by diabetes mellitus, unable to ingest food p.o. such as esophageal cancer or other diseases.

Role of monovalent cations in fluid secretion from the exocrine rabbit pancreas.

PubMed

Kuijpers, G A; Van Nooy, I G; De Pont, J J

1989-08-21

The role of Na+ in fluid secretion by the isolated rabbit pancreas was investigated. The fluid secretion rate is reduced upon replacement of Na+ in the bathing medium by Li+, K+ or choline. The inhibition depends on the nature of the substituting cation, and is largest with choline. Upon replacement, the substituent cation appears in the secreted fluid, and the Na+ concentration in the secreted fluid is decreased in a mirror-like fashion. When Na+ is replaced by Li+ or choline, the secretory Na+ concentration is decreased, although less than in the bathing medium, and the K+ concentration is increased. When Na+ is replaced by K+, the Na+ and the K+ concentration in the secreted fluid are approximately equal to their bathing medium concentrations. In the Li+ and choline medium, stimulation of the pancreas by carbachol or CCK-8 increases the fluid secretion rate. In addition, it increases the Li+ or choline concentration, and decreases the Na+ and K+ concentrations in the secreted fluid. In normal and K+ medium, stimulation causes only a slight increase in fluid secretion rate, with no change in the secretory Na+ concentration. In normal medium, stimulation leads to a decrease in the secretory K+ concentration. The effects of replacing Na+ appear to be the result of a direct inhibition of the active HCO3- transport underlying secretion, and an indirect inhibition related to the permeability of the pancreas for the various cations. The stimulants are likely to act by increasing the permeability of the tight junctions.

Characterization of renal response to prolonged immersion in normal man

NASA Technical Reports Server (NTRS)

Epstein, M.; Denunzio, A. G.; Ramachandran, M.

1980-01-01

?jDuring the initial phase of space flight, there is a translocation of fluid from the lower parts of the body to the central vascular compartment with a resultant natriuresis, diuresis, and weight loss. Because water immersion is regarded as an appropriate model for studying the redistribution of fluid that occurs in weightlessness, an immersion study of relatively prolonged duration was carried out in order to characterize the temporal profile of the renal adaptation to central hypervolemia. Twelve normal male subjects underwent an immersion study of 8-h duration in the sodium-replete state. Immersion resulted in marked natriuresis and diuresis which were sustained throughout the immersion period. The failure of that natriuresis and diuresis of immersion to abate or cease despite marked extracellular fluid volume contraction as evidenced by a mean weight loss of -2.2 + or - 0.3 kg suggests that central blood volume was not restored to normal and that some degree of central hypervolemia probably persisted.

Structure design of and experimental research on a two-stage laval foam breaker for foam fluid recycling.

PubMed

Wang, Jin-song; Cao, Pin-lu; Yin, Kun

2015-07-01

Environmental, economical and efficient antifoaming technology is the basis for achievement of foam drilling fluid recycling. The present study designed a novel two-stage laval mechanical foam breaker that primarily uses vacuum generated by Coanda effect and Laval principle to break foam. Numerical simulation results showed that the value and distribution of negative pressure of two-stage laval foam breaker were larger than that of the normal foam breaker. Experimental results showed that foam-breaking efficiency of two-stage laval foam breaker was higher than that of normal foam breaker, when gas-to-liquid ratio and liquid flow rate changed. The foam-breaking efficiency of normal foam breaker decreased rapidly with increasing foam stability, whereas the two-stage laval foam breaker remained unchanged. Foam base fluid would be recycled using two-stage laval foam breaker, which would reduce the foam drilling cost sharply and waste disposals that adverse by affect the environment.

Effect of a single intra-articular injection of bupivacaine on synovial fluid prostaglandin E2 concentrations in normal canine stifles.

PubMed

Giangarra, Jenna E; Barry, Sabrina L; Dahlgren, Linda A; Lanz, Otto I; Benitez, Marian E; Werre, Stephen R

2018-04-25

To identify if synovial fluid prostaglandin E 2 increases in response to a single intra-articular dose of bupivacaine in the normal canine stifle. There were no significant differences in synovial fluid prostaglandin E 2 (PGE 2 ) concentrations between treatment groups or over time within bupivacaine or saline groups. Samples requiring ≥ 3 arthrocentesis attempts had significantly higher PGE 2 concentrations compared to samples requiring 1 or 2 attempts. Following correction for number of arthrocentesis attempts, PGE 2 concentrations were significantly higher than baseline at 24 and 48 h in the bupivacaine group; however there were no significant differences between the bupivacaine and saline groups. In normal dogs, a single bupivacaine injection did not cause significant synovial inflammation, as measured by PGE 2 concentrations, compared to saline controls. Future research should minimize aspiration attempts and include evaluation of the synovial response to bupivacaine in clinical cases with joint disease.

Space station integrated propulsion and fluid system study: Fluid systems configuration databook

NASA Technical Reports Server (NTRS)

Rose, L.; Bicknell, B.; Bergman, D.; Wilson, S.

1987-01-01

This databook contains fluid system requirements and system descriptions for Space Station program elements including the United States and International modules, integrated fluid systems, attached payloads, fluid servicers and vehicle accommodation facilities. Separate sections are devoted to each of the program elements and include a discussion of the overall system requirements, specific fluid systems requirements and systems descriptions. The systems descriptions contain configurations, fluid inventory data and component lists. In addition, a list of information sources is referenced at the end of each section.

Microscopic FTIR studies of lung cancer cells in pleural fluid.

PubMed

Wang, H P; Wang, H C; Huang, Y J

1997-10-01

Structural changes associated with lung cancer and tuberculous cells in pleural fluid were studied by microscopic FTIR spectroscopy. Infrared spectra demonstrate significant spectral differences between normal, lung cancer and tuberculous cells. The ratio of the peak intensities of the 1030 and 1080 cm-1 bands (originated mainly in glycogen and phosphodiester groups of nucleic acids) differs greatly between normal and lung cancer samples. Such findings prompt the consideration that recording infrared spectra from lung cancer and tuberculous cells may be of diagnostic value. Since measurements of IR spectra of lung cancer cells in the pleural fluid can be a very rapid inexpensive process, our finding warrant exploration of this possibility in the investigation of the mechanism whereby the environmental pollution related cancers develop.

The Impact of Mass Movement and Fluid Flow during Ridge Subduction inferred from Physical Properties and Zeolite Assemblage in the Upper Plate Slope of the Costa Rica Subduction Zone

NASA Astrophysics Data System (ADS)

Hamahashi, M.; Screaton, E.; Tanikawa, W.; Hashimoto, Y.; Martin, K. M.; Saito, S.; Kimura, G.

2015-12-01

The Costa Rica subduction zone offshore Osa Peninsula is known as an erosive margin with active seismicity and the subduction of the Cocos Ridge. One of the major unknowns in this margin is the nature of the unconformity at the base of the slope sediments in the upper plate and the high velocity materials below. To investigate the geologic processes across the unconformity, we examined the consolidation state and mineral assemblages of the sediments at the mid-slope Site 1380 drilled during IODP Expedition 344 by conducting microstructural observation, particle size analysis, X-ray fluorescence/diffraction analysis and resistivity measurement. The general compaction trend is controlled primarily by grain-size sorting and the physical property transition is likely caused by massive sediment removal under normal fault regime, thickness of which range between ~600-850 m determined from the composite porosity-depth curve. Across the unconformity between the late Pliocene~late Pleistocene silty clay (Unit 1) and late Pliocene~early Pleistocene clayey siltstone (Unit 2), the mineral/element components of the sediments is marked by the transitions in zeolite compositions; Unit 1 consists of laumontite and heulandite, whereas below the unconformity, Unit 2 sediments contain analcime, laumontite, and heulandite, but laumontite become less abundant at lower depth. The experienced temperature of the sediments in Unit 2 is estimated to have reached between ~86 and 122℃ as inferred from analcime burial diagenesis. This may correspond with the greater depth range prior to mass movement and normal faulting. The initial analcime burial diagenetic zone was likely cut off by the sediment removal across the unconformity, and later overprinted by high temperature fluid along the boundary forming laumontite and heulandite in the vicinity. These results illustrate that ridge subduction has substantial potential to cause mass movement, an extensional stress regime, and fluid flow from depth.

Multivariate Associations of Fluid Intelligence and NAA.

PubMed

Nikolaidis, Aki; Baniqued, Pauline L; Kranz, Michael B; Scavuzzo, Claire J; Barbey, Aron K; Kramer, Arthur F; Larsen, Ryan J

2017-04-01

Understanding the neural and metabolic correlates of fluid intelligence not only aids scientists in characterizing cognitive processes involved in intelligence, but it also offers insight into intervention methods to improve fluid intelligence. Here we use magnetic resonance spectroscopic imaging (MRSI) to measure N-acetyl aspartate (NAA), a biochemical marker of neural energy production and efficiency. We use principal components analysis (PCA) to examine how the distribution of NAA in the frontal and parietal lobes relates to fluid intelligence. We find that a left lateralized frontal-parietal component predicts fluid intelligence, and it does so independently of brain size, another significant predictor of fluid intelligence. These results suggest that the left motor regions play a key role in the visualization and planning necessary for spatial cognition and reasoning, and we discuss these findings in the context of the Parieto-Frontal Integration Theory of intelligence. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Study of blood flow in several benchmark micro-channels using a two-fluid approach

PubMed Central

Wu, Wei-Tao; Yang, Fang; Antaki, James F.; Aubry, Nadine; Massoudi, Mehrdad

2015-01-01

It is known that in a vessel whose characteristic dimension (e.g., its diameter) is in the range of 20 to 500 microns, blood behaves as a non-Newtonian fluid, exhibiting complex phenomena, such as shear-thinning, stress relaxation, and also multi-component behaviors, such as the Fahraeus effect, plasma-skimming, etc. For describing these non-Newtonian and multi-component characteristics of blood, using the framework of mixture theory, a two-fluid model is applied, where the plasma is treated as a Newtonian fluid and the red blood cells (RBCs) are treated as shear-thinning fluid. A computational fluid dynamic (CFD) simulation incorporating the constitutive model was implemented using OpenFOAM® in which benchmark problems including a sudden expansion and various driven slots and crevices were studied numerically. The numerical results exhibited good agreement with the experimental observations with respect to both the velocity field and the volume fraction distribution of RBCs. PMID:26240438

Mesh-free distributed point source method for modeling viscous fluid motion between disks vibrating at ultrasonic frequency.

PubMed

Wada, Yuji; Kundu, Tribikram; Nakamura, Kentaro

2014-08-01

The distributed point source method (DPSM) is extended to model wave propagation in viscous fluids. Appropriate estimation on attenuation and boundary layer formation due to fluid viscosity is necessary for the ultrasonic devices used for acoustic streaming or ultrasonic levitation. The equations for DPSM modeling in viscous fluids are derived in this paper by decomposing the linearized viscous fluid equations into two components-dilatational and rotational components. By considering complex P- and S-wave numbers, the acoustic fields in viscous fluids can be calculated following similar calculation steps that are used for wave propagation modeling in solids. From the calculations reported the precision of DPSM is found comparable to that of the finite element method (FEM) for a fundamental ultrasonic field problem. The particle velocity parallel to the two bounding surfaces of the viscous fluid layer between two rigid plates (one in motion and one stationary) is calculated. The finite element results agree well with the DPSM results that were generated faster than the transient FEM results.

Dual laser optical system and method for studying fluid flow

NASA Technical Reports Server (NTRS)

Owen, R. B.; Witherow, W. K. (Inventor)

1983-01-01

A dual laser optical system and method is disclosed for visualization of phenomena in transport substances which induce refractive index gradients such as fluid flow and pressure and temperature gradients in fluids and gases. Two images representing mutually perpendicular components of refractive index gradients may be viewed simultaneously on screen. Two lasers having wave lengths in the visible range but separated by about 1000 angstroms are utilized to provide beams which are collimated into a beam containing components of the different wave lengths. The collimated beam is passed through a test volume of the transparent substance. The collimated beam is then separated into components of the different wave lengths and focused onto a pair of knife edges arranged mutually perpendicular to produce and project images onto the screen.

Chloride - urine test

MedlinePlus

... of a condition that affects body fluids or acid-base balance. Normal Results The normal range is 110 ... in the clinical evaluation of electrolyte, water, and acid-base disorders. In: Alpern RJ, Moe OW, Caplan M, ...

Theories of binary fluid mixtures: from phase-separation kinetics to active emulsions

NASA Astrophysics Data System (ADS)

Cates, Michael E.; Tjhung, Elsen

2018-02-01

Binary fluid mixtures are examples of complex fluids whose microstructure and flow are strongly coupled. For pairs of simple fluids, the microstructure consists of droplets or bicontinuous demixed domains and the physics is controlled by the interfaces between these domains. At continuum level, the structure is defined by a composition field whose gradients which are steep near interfaces drive its diffusive current. These gradients also cause thermodynamic stresses which can drive fluid flow. Fluid flow in turn advects the composition field, while thermal noise creates additional random fluxes that allow the system to explore its configuration space and move towards the Boltzmann distribution. This article introduces continuum models of binary fluids, first covering some well-studied areas such as the thermodynamics and kinetics of phase separation, and emulsion stability. We then address cases where one of the fluid components has anisotropic structure at mesoscopic scales creating nematic (or polar) liquid-crystalline order; this can be described through an additional tensor (or vector) order parameter field. We conclude by outlining a thriving area of current research, namely active emulsions, in which one of the binary components consists of living or synthetic material that is continuously converting chemical energy into mechanical work.

Influence of Anti-inflammatory Drugs on the Rheological Properties of Synovial Fluid and Its Components

NASA Astrophysics Data System (ADS)

Krause, Wendy E.; Klossner, Rebecca R.; Liang, Jing; Colby, Ralph H.

2006-03-01

The polyelectrolyte hyaluronic acid (HA, hyaluronan), its interactions with anti-inflammatory drugs and other biopolymers, and its role in synovial fluid are being studied. We are investigating the rheological properties of sodium hyaluronate (NaHA) solutions and an experimental model of synovial fluid (comprised of NaHA, and the plasma proteins albumin and γ-globulins). Steady shear measurements on bovine synovial fluid, the synovial fluid model, and plasma protein solutions indicate that the fluids are rheopectic (stress increases with time under steady shear). In addition, the influence of anti-inflammatory agents on these solutions is being explored. Initial results indicate that D-penicillamine and hydroxychloroquine (HCQ) affect the rheology of the synovial fluid model and its components. While HCQ has no effect on the viscosity of NaHA solutions, it inhibits/suppresses the observed rheopexy of the synovial fluid model and plasma protein solutions. In contrast, D-penicillamine has a complex, time dependent effect on the viscosity of NaHA solutions,---reducing the zero shear rate viscosity of a 3 mg/mL NaHA (in phosphate buffered saline) by ca. 40% after 44 days. The potential implications of these results will be discussed.

Normal values for segmental bioimpedance spectroscopy in pediatric patients.

PubMed

Avila, Maria Laura; Ward, Leigh C; Feldman, Brian M; Montoya, Madeline I; Stinson, Jennifer; Kiss, Alex; Brandão, Leonardo R

2015-01-01

Localized limb edema is a clinically relevant sign in diseases such as post-thrombotic syndrome and lymphedema. Quantitative evaluation of localized edema in children is mainly done by measuring the absolute difference in limb circumference, which includes fat and fat-free mass. Bioimpedance spectroscopy (BIS) provides information on the fluid volume of a body segment. Our objective was to determine normal ranges for segmental (arm and leg) BIS measurements in healthy children. Additionally, we determined the normal ranges for the difference in arm and ankle circumference and explored the influence of handedness and the correlation between techniques. Healthy children aged 1-18 years were recruited. The ratio of extracellular fluid content between contralateral limbs (estimated as the inter-arm and inter-leg extracellular impedance ratio), and the ratio of extracellular to intracellular fluid content for each limb (estimated as the intracellular to extracellular impedance ratio) were determined with a bioimpedance spectrometer. Arm and ankle circumference was determined with a Gulick II tape. We recruited 223 healthy children (48 infants, 54 preschoolers, 66 school-aged children, and 55 teenagers). Normal values for arm and leg BIS measurements, and for the difference in arm and ankle circumference were estimated for each age category. No influence of handedness was found. We found a statistically significant correlation between extracellular impedance ratio and circumference difference for arms among teenagers. We determined normal BIS ranges for arms and legs and for the difference in circumference between arms and between ankles in children. There was no statistically significant correlation between extracellular impedance ratio and difference in circumference, except in the case of arms in adolescents. This may indicate that limb circumference measures quantities other than fluid, challenging the adequacy of this technique to determine the presence of localized edema in most age groups.

Human Health Concenrs of Metalworking Fluid Components

NASA Astrophysics Data System (ADS)

Gerulová, Kristína; Buranská, Eva; Soldán, Maroš

2017-06-01

Exploration of 209 available Material safety data sheets of 85 straight oils, 46 emulsions, 51 semi-synthetics and 27 synthetics was carried out to provide a report on the most widely used components defined as dangerous substances. As many as 217 of different substances of which 15 were identified as biocides, 17 as corrosion inhibitors or neutralizing agent, 17 were lubricity improvers and 38 different base fluids, lubricity solvents or surfactants, while 93 substances were not identified specifically and 37 substances occurred only once. This article is focused on the list of base fluids in straight oils and their possible health effects.

Quantum turbulence in superfluids with wall-clamped normal component.

PubMed

Eltsov, Vladimir; Hänninen, Risto; Krusius, Matti

2014-03-25

In Fermi superfluids, such as superfluid (3)He, the viscous normal component can be considered to be stationary with respect to the container. The normal component interacts with the superfluid component via mutual friction, which damps the motion of quantized vortex lines and eventually couples the superfluid component to the container. With decreasing temperature and mutual friction, the internal dynamics of the superfluid component becomes more important compared with the damping and coupling effects from the normal component. As a result profound changes in superfluid dynamics are observed: the temperature-dependent transition from laminar to turbulent vortex motion and the decoupling from the reference frame of the container at even lower temperatures.

Quantum turbulence in superfluids with wall-clamped normal component

PubMed Central

Eltsov, Vladimir; Hänninen, Risto; Krusius, Matti

2014-01-01

In Fermi superfluids, such as superfluid 3He, the viscous normal component can be considered to be stationary with respect to the container. The normal component interacts with the superfluid component via mutual friction, which damps the motion of quantized vortex lines and eventually couples the superfluid component to the container. With decreasing temperature and mutual friction, the internal dynamics of the superfluid component becomes more important compared with the damping and coupling effects from the normal component. As a result profound changes in superfluid dynamics are observed: the temperature-dependent transition from laminar to turbulent vortex motion and the decoupling from the reference frame of the container at even lower temperatures. PMID:24704879

Regional dolomitization of the Waulsortian limestone in southeastern Ireland: Evidence of large-scale fluid flow driven by the Hercynian orogeny

NASA Astrophysics Data System (ADS)

Hitzman, M. W.; Allan, J. R.; Beaty, D. W.

1998-06-01

The Lower Carboniferous Waulsortian limestone has been affected by late diagenetic, regional burial dolomitization over an area of ˜7000 km2 extending 170 km northeastward from the Hercynian front. The dolostone is composed of two components: (1) a very fine crystalline replacive component, and (2) a coarse-crystalline, baroque component that fills vuggy porosity developed within the replacive dolostone. Fluid inclusions within the coarse-crystalline component of the regional dolostone indicate that the dolomitizing solutions were warm (˜100 °C) and moderately saline (10 13 wt% NaCl equivalent). The replacive dolomite displays systematic decreases in crystal size and degree of xenotopic texture northward. Both components of the regional dolostone display a regular northward increase in mean δ18O values; the replacive dolomite has 87Sr/86Sr values that decrease northward. These laterally variable characteristics suggest that regional dolomitization resulted from large-scale, north-directed fluid flow of heated brines developed in response to topographic uplift associated with collapse of the continental margin south of Ireland during the Hercynian (Variscan) orogeny.

Elevated synovial fluid concentration of adenosine triphosphate in dogs with osteoarthritis or sodium urate-induced synovitis of the stifle.

PubMed

Torres, Bryan T; Jimenez, David A; Budsberg, Steven C

2016-07-19

Adenosine triphosphate has been shown to stimulate nociceptive nerve terminals in joints. Elevated synovial fluid adenosine triphosphate concentrations as well as a correlation between synovial fluid adenosine triphosphate concentrations and osteoarthritic knee pain has been demonstrated in humans, but not yet in dogs. This study documented elevated synovial fluid adenosine triphosphate concentrations in the stifles of dogs with secondary osteoarthritis and urate-induced synovitis, as compared to normal stifles.

Space station integrated propulsion and fluid systems study. Space station program fluid management systems databook

NASA Technical Reports Server (NTRS)

Bicknell, B.; Wilson, S.; Dennis, M.; Lydon, M.

1988-01-01

Commonality and integration of propulsion and fluid systems associated with the Space Station elements are being evaluated. The Space Station elements consist of the core station, which includes habitation and laboratory modules, nodes, airlocks, and trusswork; and associated vehicles, platforms, experiments, and payloads. The program is being performed as two discrete tasks. Task 1 investigated the components of the Space Station architecture to determine the feasibility and practicality of commonality and integration among the various propulsion elements. This task was completed. Task 2 is examining integration and commonality among fluid systems which were identified by the Phase B Space Station contractors as being part of the initial operating capability (IOC) and growth Space Station architectures. Requirements and descriptions for reference fluid systems were compiled from Space Station documentation and other sources. The fluid systems being examined are: an experiment gas supply system, an oxygen/hydrogen supply system, an integrated water system, the integrated nitrogen system, and the integrated waste fluids system. Definitions and descriptions of alternate systems were developed, along with analyses and discussions of their benefits and detriments. This databook includes fluid systems descriptions, requirements, schematic diagrams, component lists, and discussions of the fluid systems. In addition, cost comparison are used in some cases to determine the optimum system for a specific task.

Effects of coarse grain size distribution and fine particle content on pore fluid pressure and shear behavior in experimental debris flows

NASA Astrophysics Data System (ADS)

Kaitna, Roland; Palucis, Marisa C.; Yohannes, Bereket; Hill, Kimberly M.; Dietrich, William E.

2016-02-01

Debris flows are typically a saturated mixture of poorly sorted particles and interstitial fluid, whose density and flow properties depend strongly on the presence of suspended fine sediment. Recent research suggests that grain size distribution (GSD) influences excess pore pressures (i.e., pressure in excess of predicted hydrostatic pressure), which in turn plays a governing role in debris flow behaviors. We report a series of controlled laboratory experiments in a 4 m diameter vertically rotating drum where the coarse particle size distribution and the content of fine particles were varied independently. We measured basal pore fluid pressures, pore fluid pressure profiles (using novel sensor probes), velocity profiles, and longitudinal profiles of the flow height. Excess pore fluid pressure was significant for mixtures with high fines fraction. Such flows exhibited lower values for their bulk flow resistance (as measured by surface slope of the flow), had damped fluctuations of normalized fluid pressure and normal stress, and had velocity profiles where the shear was concentrated at the base of the flow. These effects were most pronounced in flows with a wide coarse GSD distribution. Sustained excess fluid pressure occurred during flow and after cessation of motion. Various mechanisms may cause dilation and contraction of the flows, and we propose that the sustained excess fluid pressures during flow and once the flow has stopped may arise from hindered particle settling and yield strength of the fluid, resulting in transfer of particle weight to the fluid. Thus, debris flow behavior may be strongly influenced by sustained excess fluid pressures controlled by particle settling rates.

Numerical simulations of stick-slip in fluid saturated granular fault gouge

NASA Astrophysics Data System (ADS)

Dorostkar, O.; Johnson, P. A.; Guyer, R. A.; Marone, C.; Carmeliet, J.

2016-12-01

Fluids play a key role in determining the frictional strength and stability of faults. For example, fluid flow and fluid-solid interaction in fault gouge can trigger seismicity, alter earthquake nucleation properties and cause fault zone weakening. We present results of 3D numerical simulations of stick-slip behavior in dry and saturated granular fault gouge. In the saturated case, the gouge is fully saturated and drainage is possible through the boundaries. We model the solid phase (particles) with the discrete element method (DEM) while the fluid is described by the Navier-Stokes equations and solved by computational fluid dynamics (CFD). In our model, granular gouge is sheared between two rough plates under boundary conditions of constant normal stress and constant shearing velocity at the layer boundaries. A phase-space study including shearing velocity and normal stress is taken to identify the conditions for stick-slip regime. We analyzed slip events for dry and saturated cases to determine shear stress drop, released kinetic energy and compaction. The presence of fluid tends to cause larger slip events. We observe a close correlation between the kinetic energy of the particles and of the fluid. In short, during slip, fluid flow induced by the failure and compaction of the granular system, mobilizes the particles, which increases their kinetic energy, leading to greater slip. We further observe that the solid-fluid interaction forces are equal or larger than the solid-solid interaction forces during the slip event, indicating the important influence of the fluid on the granular system. Our simulations can explain the behaviors observed in experimental studies and we are working to apply our results to tectonic faults.

Excess flow shutoff valve

DOEpatents

Kiffer, Micah S.; Tentarelli, Stephen Clyde

2016-02-09

Excess flow shutoff valve comprising a valve body, a valve plug, a partition, and an activation component where the valve plug, the partition, and activation component are disposed within the valve body. A suitable flow restriction is provided to create a pressure difference between the upstream end of the valve plug and the downstream end of the valve plug when fluid flows through the valve body. The pressure difference exceeds a target pressure difference needed to activate the activation component when fluid flow through the valve body is higher than a desired rate, and thereby closes the valve.

Motion estimation under location uncertainty for turbulent fluid flows

NASA Astrophysics Data System (ADS)

Cai, Shengze; Mémin, Etienne; Dérian, Pierre; Xu, Chao

2018-01-01

In this paper, we propose a novel optical flow formulation for estimating two-dimensional velocity fields from an image sequence depicting the evolution of a passive scalar transported by a fluid flow. This motion estimator relies on a stochastic representation of the flow allowing to incorporate naturally a notion of uncertainty in the flow measurement. In this context, the Eulerian fluid flow velocity field is decomposed into two components: a large-scale motion field and a small-scale uncertainty component. We define the small-scale component as a random field. Subsequently, the data term of the optical flow formulation is based on a stochastic transport equation, derived from the formalism under location uncertainty proposed in Mémin (Geophys Astrophys Fluid Dyn 108(2):119-146, 2014) and Resseguier et al. (Geophys Astrophys Fluid Dyn 111(3):149-176, 2017a). In addition, a specific regularization term built from the assumption of constant kinetic energy involves the very same diffusion tensor as the one appearing in the data transport term. Opposite to the classical motion estimators, this enables us to devise an optical flow method dedicated to fluid flows in which the regularization parameter has now a clear physical interpretation and can be easily estimated. Experimental evaluations are presented on both synthetic and real world image sequences. Results and comparisons indicate very good performance of the proposed formulation for turbulent flow motion estimation.

Alteration of fault rocks by CO2-bearing fluids with implications for sequestration

NASA Astrophysics Data System (ADS)

Luetkemeyer, P. B.; Kirschner, D. L.; Solum, J. G.; Naruk, S.

2011-12-01

Carbonates and sulfates commonly occur as primary (diagenetic) pore cements and secondary fluid-mobilized veins within fault zones. Stable isotope analyses of calcite, formation fluid, and fault zone fluids can help elucidate the carbon sources and the extent of fluid-rock interaction within a particular reservoir. Introduction of CO2 bearing fluids into a reservoir/fault system can profoundly affect the overall fluid chemistry of the reservoir/fault system and may lead to the enhancement or degradation of porosity within the fault zone. The extent of precipitation and/or dissolution of minerals within a fault zone can ultimately influence the sealing properties of a fault. The Colorado Plateau contains a number of large carbon dioxide reservoirs some of which leak and some of which do not. Several normal faults within the Paradox Basin (SE Utah) dissect the Green River anticline giving rise to a series of footwall reservoirs with fault-dependent columns. Numerous CO2-charged springs and geysers are associated with these faults. This study seeks to identify regional sources and subsurface migration of CO2 to these reservoirs and the effect(s) faults have on trap performance. Data provided in this study include mineralogical, elemental, and stable isotope data for fault rocks, host rocks, and carbonate veins that come from two localities along one fault that locally sealed CO2. This fault is just tens of meters away from another normal fault that has leaked CO2-charged waters to the land surface for thousands of years. These analyses have been used to determine the source of carbon isotopes from sedimentary derived carbon and deeply sourced CO2. XRF and XRD data taken from several transects across the normal faults are consistent with mechanical mixing and fluid-assisted mass transfer processes within the fault zone. δ13C range from -6% to +10% (PDB); δ18O values range from +15% to +24% (VSMOW). Geochemical modeling software is used to model the alteration productions of fault rocks from fluids of various chemistries coming from several different reservoirs within an active CO2-charged fault system. These results are compared to data obtained in the field.

The Role of Siliceous Hydrothermal Breccias in the Genesis of Volcanic Massive Sulphide Deposits - Ancient and Recent Systems

NASA Astrophysics Data System (ADS)

Costa, I. A.; Barriga, F. J.; Fouquet, Y.

2014-12-01

Siliceous hydrothermal breccias were sampled in two Mid-Atlantic Ridge active sites: Lucky Strike and Menez Gwen. These hydrothermal fields are located in the border of the Azorean plateau, southwest of the Azores islands where the alteration processes affecting basaltic rocks are prominent (Costa et al., 2003). The hydrothermal breccias are genetically related with the circulation of low temperature hydrothermal fluids in diffuse vents. The groundmass of these breccias precipitates from the fluid and consolidates the clastic fragments mostly composed of basalt. The main sources are the surrounding volcanic hills. Breccias are found near hydrothermal vents and may play an important role in the protection of subseafloor hydrothermal deposits forming an impermeable cap due to the high content in siliceous material. The amorphous silica tends to precipitate when the fluid is conductively cooled as proposed by Fouquet et al. (1998) after Fournier (1983). The process evolves gradually from an initial stage where we have just the fragments and circulating seawater. The ascending hydrothermal fluid mixes with seawater, which favours the precipitation of the sulphide components. Sealing of the initially loose fragments begins, the temperature rises below this crust, and the processes of mixing fluid circulation and conductive cooling are simultaneous. At this stage the fluid becomes oversaturated with respect to amorphous silica. This form of silica can precipitate in the open spaces of the porous sulphides and seal the system. Normally this can happen at low temperatures. At this stage the hydrothermal breccia is formed creating a progressively less permeable, eventually impermeable cap rock at the surface. Once the fluid is trapped under this impermeable layer, conductive cooling is enhanced and mixing with seawater is restricted, making the precipitation of amorphous silica more efficient. Since the first discovery and description of recent mineralized submarine hydrothermal deposits, comparison with ancient volcanic massive sulphide deposits is appropriate. The proposed model can explain some of the processes taking place in the early phase of formation of old deposits where equivalent siliceous material is found in the hanging wall of the ore bodies (e.g. Barriga and Fyfe, 1988).

Methods for separating a fluid, and devices capable of separating a fluid

DOEpatents

TeGrotenhuis, Ward E; Humble, Paul H; Caldwell, Dustin D

2013-05-14

Methods and apparatus for separating fluids are disclosed. We have discovered that, surprisingly, providing an open pore structure between a wick and an open flow channel resulted in superior separation performance. A novel and compact integrated device components for conducting separations are also described.

Self-thermophoresis and thermal self-diffusion in liquids and gases.

PubMed

Brenner, Howard

2010-09-01

This paper demonstrates the existence of self-thermophoresis, a phenomenon whereby a virtual thermophoretic force arising from a temperature gradient in a quiescent single-component liquid or gas acts upon an individual molecule of that fluid in much the same manner as a "real" thermophoretic force acts upon a macroscopic, non-Brownian body immersed in that same fluid. In turn, self-thermophoresis acting in concert with Brownian self-diffusion gives rise to the phenomenon of thermal self-diffusion in single-component fluids. The latter furnishes quantitative explanations of both thermophoresis in pure fluids and thermal diffusion in binary mixtures (the latter composed of a dilute solution of a physicochemically inert solute whose molecules are large compared with those of the solvent continuum). Explicitly, the self-thermophoretic theory furnishes a simple expression for both the thermophoretic velocity U of a macroscopic body in a single-component fluid subjected to a temperature gradient ∇T , and the intimately related binary thermal diffusion coefficient D{T} for a two-component colloidal or macromolecular mixture. The predicted expressions U=-D{T}∇T≡-βD{S}∇T and D{T}=βD{S} (with β and D{S} the pure solvent's respective thermal expansion and isothermal self-diffusion coefficients) are each noted to accord reasonably well with experimental data for both liquids and gases. The likely source of systematic deviations of the predicted values of D{T} from these data is discussed. This appears to be the first successful thermodiffusion theory applicable to both liquids and gases, a not insignificant achievement considering that the respective thermal diffusivities and thermophoretic velocities of these two classes of fluids differ by as much as six orders of magnitude.

Experimental analysis on viscoelasticity-induced migration of RBCs using digital holographic microscopy

NASA Astrophysics Data System (ADS)

Go, Taesik; Byeon, Hyeokjun; Lee, Sang Joon

2016-11-01

Migration of particles in viscoelastic fluids has recently received large attention, because the generated elastic forces in viscoelastic fluids give rise to a simple focusing pattern over a wide range of flow rates. In this study, the vertical focusing and alignment of rigid spherical particles, normal and hardened RBCs in a viscoelastic fluid were experimentally investigated by employing a digital in-line holographic microscopy (DIHM). By the elastic forces, the three different particles are pushed away from the walls and concentrated in the midplane of the rectangular microchannel. Furthermore, most of both RBCs maintain face-on orientation in the microchannel. The effects of deformability of RBC on the viscoelasticity-induced migration and orientation in the channel were also examined. In contrary to non-deformable particles, normal RBCs are dispersed as flow rate increases. In the region near side wall of the microchannel, normal RBCs have edge-on orientation with a large angle of inclination, compared to hardened RBCs. These findings have a strong potential in the design of microfluidic devices for deformability-based separation of cells in viscoelastic fluid flows and label-free diagnoses of certain hematological diseases. This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIP) (No. 2008-0061991).

Detection of bacterial DNA by PCR in dogs with stifle pathology.

PubMed

Bhandal, Jitender; Hayashi, Kei; Kim, Sun-Young; Klein, Martha; Wong, Alice; Toupadakis, Chrisoula A; Muir, Peter; Yellowley, Clare E

2013-10-01

To determine presence of bacterial DNA in canine stifles with cranial cruciate ligament rupture (CCLR) and medial patellar luxation (MPL) compared to normal canine stifles (control). Prospective clinical study. Dogs (n = 44). Dogs of varying age, breed, sex, and weight residing in California were assessed for stifle pathology (CCLR, MPL, or normal control). Synovial fluid of all stifles was assessed for the presence of bacterial DNA using broad-ranging 16S rRNA primers and PCR. Bacterial DNA was detected in normal control stifles and those with CCLR and MPL. There were no statistical differences in the copy numbers of bacterial DNA in the stifle synovial fluid among groups (P > .05); however, synovial fluid specimens from dogs with stifle pathology (CCLR and MPL combined) tended to have higher copy numbers of bacterial DNA than those from controls (P = .06). There was no significant difference in the number of bacterial DNA between the CCLR and MPL groups (P = .57). The copy numbers of bacterial DNA had a weak positive significant correlation with the duration of lameness in CCLR group (P < .05). Increased detection of bacterial DNA in the stifle synovial fluid may indicate joint pathology but not be directly linked to a specific joint disease. © Copyright 2013 by The American College of Veterinary Surgeons.

Relationship of IgG, C3 and transferrin with opsonising and bacteriostatic activity of peritoneal fluid from CAPD patients and the incidence of peritonitis.

PubMed

McGregor, S J; Brock, J H; Briggs, J D; Junor, B J

1987-01-01

IgG, C3 and transferrin in peritoneal dialysis effluent of patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were 1%-2% of those in serum. In contrast, the values in normal peritoneal fluid were not significantly different from those in serum. The three proteins correlated with each other in peritoneal dialysis effluent, but were independent of the amount in the corresponding patients' sera. There was also an overall inverse correlation between total protein in peritoneal dialysis effluent and time on CAPD during the first 6 months of treatment but not thereafter, which suggests that changes in membrane permeability occur during the early months. In peritoneal dialysis effluent, but not in normal peritoneal fluid, there was a correlation between opsonising capacity and IgG or C3 concentrations. An inverse correlation between opsonic activity of peritoneal dialysis effluent and frequency of peritonitis was also found. Peritoneal dialysis effluent permitted significantly faster multiplication of Staphylococcus epidermidis than sera or normal peritoneal fluid, and the growth rate correlated inversely with the transferrin levels in peritoneal dialysis effluent. Overall IgG, C3 and transferrin in peritoneal dialysis effluent are inadequate for optimal opsonising and bacteriostatic activity, and the peritoneal cavities of CAPD patients are therefore immunocompromised sites.

Space and Missile Systems Center Standard: Space Flight Pressurized Systems

DTIC Science & Technology

2015-02-28

24 5.7.2 Fire Resistant Fluids ......................................................................................... 24 5.7.3...connections. 5.1.7 Threaded Parts [5.1.7-1] All threaded parts in components shall be securely locked to resist uncoupling forces by acceptable safe... Resistant Fluids [5.7.2-1] Fire resistant or flame proof hydraulic fluid shall be used where the system design can expose hydraulic fluid to potential

Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid

PubMed Central

Merrick, John; Lane, Brian; Sebree, Terri; Yaksh, Tony; O'Neill, Carol; Banks, Stan L.

2016-01-01

Abstract Introduction: In recent research, orally administered cannabidiol (CBD) showed a relatively high incidence of somnolence in a pediatric population. Previous work has suggested that when CBD is exposed to an acidic environment, it degrades to Δ9-tetrahydrocannabinol (THC) and other psychoactive cannabinoids. To gain a better understanding of quantitative exposure, we completed an in vitro study by evaluating the formation of psychoactive cannabinoids when CBD is exposed to simulated gastric fluid (SGF). Methods: Materials included synthetic CBD, Δ8-THC, and Δ9-THC. Linearity was demonstrated for each component over the concentration range used in this study. CBD was spiked into media containing 1% sodium dodecyl sulfate (SDS). Samples were analyzed using chromatography with UV and mass spectrometry detection. An assessment time of 3 h was chosen as representative of the maximal duration of exposure to gastric fluid. Results: CBD in SGF with 1% SDS was degraded about 85% after 60 min and more than 98% at 120 min. The degradation followed first-order kinetics at a rate constant of −0.031 min−1 (R2=0.9933). The major products formed were Δ9-THC and Δ8-THC with less significant levels of other related cannabinoids. CBD in physiological buffer performed as a control did not convert to THC. Confirmation of THC formation was demonstrated by comparison of mass spectral analysis, mass identification, and retention time of Δ9-THC and Δ8-THC in the SGF samples against authentic reference standards. Conclusions: SGF converts CBD into the psychoactive components Δ9-THC and Δ8-THC. The first-order kinetics observed in this study allowed estimated levels to be calculated and indicated that the acidic environment during normal gastrointestinal transit can expose orally CBD-treated patients to levels of THC and other psychoactive cannabinoids that may exceed the threshold for a physiological response. Delivery methods that decrease the potential for formation of psychoactive cannabinoids should be explored. PMID:28861485

Theory of the spin-1 bosonic liquid metal - Equilibrium properties of liquid metallic deuterium

NASA Technical Reports Server (NTRS)

Oliva, J.; Ashcroft, N. W.

1984-01-01

The theory of a two-component quantum fluid comprised of spin-1/2 fermions and nonzero spin bosons is examined. This system is of interest because it embodies a possible quantum liquid metallic phase of highly compressed deuterium. Bose condensation is assumed present and the two cases of nuclear-spin-polarized and -unpolarized systems are considered. A significant feature in the unpolarized case is the presence of a nonmagnetic mode with quadratic dispersion owing its existence to nonzero boson spin. The physical character of this mode is examined in detail within a Bogoliubov approach. The specific heat, bulk modulus, spin susceptibility, and thermal expansion are all determined. Striking contrasts in the specific heats and thermal-expansion coefficients of the liquid and corresponding normal solid metallic phase are predicted.

Cartan symmetries and global dynamical systems analysis in a higher-order modified teleparallel theory

NASA Astrophysics Data System (ADS)

Karpathopoulos, L.; Basilakos, S.; Leon, G.; Paliathanasis, A.; Tsamparlis, M.

2018-07-01

In a higher-order modified teleparallel theory cosmological we present analytical cosmological solutions. In particular we determine forms of the unknown potential which drives the scalar field such that the field equations form a Liouville integrable system. For the determination of the conservation laws we apply the Cartan symmetries. Furthermore, inspired from our solutions, a toy model is studied and it is shown that it can describe the Supernova data, while at the same time introduces dark matter components in the Hubble function. When the extra matter source is a stiff fluid then we show how analytical solutions for Bianchi I universes can be constructed from our analysis. Finally, we perform a global dynamical analysis of the field equations by using variables different from that of the Hubble-normalization.

Detection and identification of oral anaerobes in intraoperative bronchial fluids of patients with pulmonary carcinoma.

PubMed

Hasegawa, Ayako; Sato, Takuichi; Hoshikawa, Yasushi; Ishida, Naoko; Tanda, Naoko; Kawamura, Yoshiaki; Kondo, Takashi; Takahashi, Nobuhiro

2014-07-01

Postoperative pneumonia may occur when upper respiratory tract protective reflexes such as cough and/or swallowing reflexes are impaired; thus, silent aspiration of oral bacteria may be a causative factor in postoperative pneumonia. This study aimed to quantify and identify bacteria in intraoperative bronchial fluids and to evaluate the relationship between impairment of cough/swallowing reflexes and silent aspiration of oral bacteria in elderly patients. After obtaining informed consent, cough and swallowing reflexes were assessed using an ultrasonic nebulizer and a nasal catheter, respectively. Using a micro-sampling probe, intraoperative bronchial fluids were collected from nine subjects with pulmonary carcinoma and cultured anaerobically on blood agar plates. After 7 days, CFUs were counted and isolated bacteria were identified by 16S rRNA gene sequencing. Four subjects (aged 71.0 ± 8.4 years) had impaired swallowing reflexes with normal cough reflexes, whereas five subjects (73.6 ± 6.5 years) had normal cough and swallowing reflexes. The bacterial counts (mean CFU ± SD) tended to be higher in intraoperative bronchial fluids of subjects with impaired swallowing reflexes ([5.1 ± 7.7] × 10(5)) than in those of subjects with normal reflexes ([1.2 ± 1.9] × 10(5)); however, this difference was not statistically significant. Predominant isolates from intraoperative bronchial fluids were Streptococcus (41.8%), Veillonella (11.4%), Gemella (8.9%), Porphyromonas (7.6%), Olsenella (6.3%) and Eikenella (6.3%). These findings indicate that intraoperative bronchial fluids contain bacteria, probably derived from the oral microbiota, and suggest that silent aspiration of oral bacteria occurs in elderly patients irrespective of impairment of swallowing reflex. © 2014 The Societies and Wiley Publishing Asia Pty Ltd.

The effect of chronic prostatitis on zinc concentration of prostatic fluid and seminal plasma: a systematic review and meta-analysis.

PubMed

Cui, Dong; Han, GuangWei; Shang, YongGang; Mu, LiJun; Long, QingZhi; Du, YueFeng

2015-01-01

Prostatitis is a common disease in urology departments. Prostatic zinc accumulation is connected with the secretory function of the prostate, and zinc concentrations present in prostatic diseases differ greatly from the normal level. Studies have investigated the effect of chronic prostatitis on zinc concentration of prostatic fluid and seminal plasma, but have shown inconsistent results. Hence, we performed a systematic literature review and meta-analysis to assess the effect of chronic prostatitis on the zinc concentration of prostatic fluid and seminal plasma. Systematic literature searches were conducted with PubMed, Embase, Science Direct/Elsevier, CNKI and the Cochrane Library up to March 2015 for case-control studies that involved the relationship between chronic prostatitis and zinc concentration of prostatic fluid and seminal plasma. Meta-analysis was performed with Review Manager and Stata software. Standard mean differences (SMDs) of zinc concentration were identified with 95% confidence intervals (95% CIs) in a random- or fixed-effects model. Our results illustrated that the zinc concentrations in prostatic fluid and seminal plasma from chronic prostatitis patients were significantly lower than normal controls (SMD [95% CI] -246.71 [-347.97, -145.44], -20.74 [-35.11, -6.37], respectively). The sample size of each study was relatively small, and a total of 731 chronic prostatitis patients and 574 normal controls were investigated in all fourteen studies. Several studies related to the subject were excluded due to lack of control data or means and standard deviations. The present study illustrates that there was a significant negative effect of chronic prostatitis on zinc concentrations of prostatic fluid and seminal plasma. Further studies with larger sample sizes are needed to better illuminate the negative impact of chronic prostatitis on zinc concentrations.

Effects of DA-6034 on aqueous tear fluid secretion and conjunctival goblet cell proliferation.

PubMed

Choi, Seul Min; Lee, Yeong Geon; Seo, Mi Jung; Kang, Kyung Koo; Ahn, Byoung Ok; Yoo, Moohi

2009-06-01

This study was conducted to evaluate the effect of DA-6034, a potent secretagogue, on aqueous tear fluid secretion and its quality in normal rabbit. We also evaluated, in animal models of experimentally induced dry eye disease, its effectiveness over time to stimulate aqueous tear production by ocular ferning test and goblet cell proliferation. Aqueous tear production, total protein levels, and glycoprotein levels in normal rabbits were evaluated after topical application of DA-6034 (0.3, 1, and 3%). Moreover, time course aqueous tear volume measurement and ocular ferning test in tear fluid were performed in dry eyes of rabbits that had been given 1% atropine sulfate, topically. Altogether, tear fluid production and conjunctival goblet cell numbers were measured in dry eyes of mice that had been given topical scopolamine. Topical application of DA-6034 (0.3, 1, and 3%) significantly increased (P < 0.05) aqueous tear production in a concentration-dependent manner in normal rabbits. There was no change in total protein levels while glycoprotein levels were significantly increased (P < 0.05) at 3% DA-6034. The increase in aqueous tear fluid was significant (P < 0.05) and lasted for 2 h post-instillation in dry eyes of rabbits that had been given 1% atropine sulfate; 10-day repeated instillation of the drug in this model resulted in large and homogeneous fern-like tear patterns. In a mouse model, DA-6034 given as a 3% eyedrop solution significantly increased (P < 0.05) tear fluid production and conjunctival goblet cell number. These results suggest that DA-6034 accelerates not only tear secretion but also mucin production and may be a potential therapeutic agent for the treatment of dry eye disease.

Ion processing element with composite media

DOEpatents

Mann, Nick R.; Tranter, Troy J.; Todd, Terry A.; Sebesta, Ferdinand

2003-02-04

An ion processing element employing composite media disposed in a porous substrate, for facilitating removal of selected chemical species from a fluid stream. The ion processing element includes a porous fibrous glass substrate impregnated by composite media having one or more active components supported by a matrix material of polyacrylonitrile. The active components are effective in removing, by various mechanisms, one or more constituents from a fluid stream passing through the ion processing element. Due to the porosity and large surface area of both the composite medium and the substrate in which it is disposed, a high degree of contact is achieved between the active component and the fluid stream being processed. Further, the porosity of the matrix material and the substrate facilitates use of the ion processing element in high volume applications where it is desired to effectively process a high volume flows.

Ion processing element with composite media

DOEpatents

Mann, Nick R [Blackfoot, ID; Tranter, Troy J [Idaho Falls, ID; Todd, Terry A [Aberdeen, ID; Sebesta, Ferdinand [Prague, CZ

2009-03-24

An ion processing element employing composite media disposed in a porous substrate, for facilitating removal of selected chemical species from a fluid stream. The ion processing element includes a porous fibrous glass substrate impregnated by composite media having one or more active components supported by a matrix material of polyacrylonitrile. The active components are effective in removing, by various mechanisms, one or more constituents from a fluid stream passing through the ion processing element. Due to the porosity and large surface area of both the composite medium and the substrate in which it is disposed, a high degree of contact is achieved between the active component and the fluid stream being processed. Further, the porosity of the matrix material and the substrate facilitates use of the ion processing element in high volume applications where it is desired to effectively process a high volume flows.

Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.

PubMed

Nagahashi, Masayuki; Yamada, Akimitsu; Miyazaki, Hiroshi; Allegood, Jeremy C; Tsuchida, Junko; Aoyagi, Tomoyoshi; Huang, Wei-Ching; Terracina, Krista P; Adams, Barbara J; Rashid, Omar M; Milstien, Sheldon; Wakai, Toshifumi; Spiegel, Sarah; Takabe, Kazuaki

2016-06-01

The tumor microenvironment is a determining factor for cancer biology and progression. Sphingosine-1-phosphate (S1P), produced by sphingosine kinases (SphKs), is a bioactive lipid mediator that regulates processes important for cancer progression. Despite its critical roles, the levels of S1P in interstitial fluid (IF), an important component of the tumor microenvironment, have never previously been measured due to a lack of efficient methods for collecting and quantifying IF. The purpose of this study is to clarify the levels of S1P in the IF from murine mammary glands and its tumors utilizing our novel methods. We developed an improved centrifugation method to collect IF. Sphingolipids in IF, blood, and tissue samples were measured by mass spectrometry. In mice with a deletion of SphK1, but not SphK2, levels of S1P in IF from the mammary glands were greatly attenuated. Levels of S1P in IF from mammary tumors were reduced when tumor growth was suppressed by oral administration of FTY720/fingolimod. Importantly, sphingosine, dihydro-sphingosine, and S1P levels, but not dihydro-S1P, were significantly higher in human breast tumor tissue IF than in the normal breast tissue IF. To our knowledge, this is the first reported S1P IF measurement in murine normal mammary glands and mammary tumors, as well as in human patients with breast cancer. S1P tumor IF measurement illuminates new aspects of the role of S1P in the tumor microenvironment.

The anatomy and physiology of normal and abnormal swallowing in oropharyngeal dysphagia.

PubMed

Sasegbon, A; Hamdy, S

2017-11-01

Eating and drinking are enjoyable activities that positively impact on an individual's quality of life. The ability to swallow food and fluid is integral to the process of eating. Swallowing occupies a dual role being both part of the enjoyment of eating and being a critically important utilitarian activity to enable adequate nutrition and hydration. Any impairment to the process of swallowing can negatively affect a person's perception of their quality of life. The process of swallowing is highly complex and involves muscles in the mouth, pharynx, larynx, and esophagus. The oropharynx is the anatomical region encompassing the oral cavity and the pharynx. Food must be masticated, formed into a bolus and transported to the pharynx by the tongue whereas fluids are usually held within the mouth before being transported ab-orally. The bolus must then be transported through the pharynx to the esophagus without any matter entering the larynx. The muscles needed for all these steps are coordinated by swallowing centers within the brainstem which are supplied with sensory information by afferent nerve fibers from several cranial nerves. The swallowing centers also receive modulatory input from higher centers within the brain. Hence, a swallow has both voluntary and involuntary physiologic components and the term dysphagia is given to difficult swallowing while oropharyngeal dysphagia is difficult swallowing due to pathology within the oropharynx. Problems affecting any point along the complex swallowing pathway can result in dysphagia. This review focuses on the anatomy and physiology behind normal and abnormal oropharyngeal swallowing. It also details the common diseases and pathology causing oropharyngeal dysphagia. © 2017 John Wiley & Sons Ltd.

Develop a Model Component

NASA Technical Reports Server (NTRS)

Ensey, Tyler S.

2013-01-01

During my internship at NASA, I was a model developer for Ground Support Equipment (GSE). The purpose of a model developer is to develop and unit test model component libraries (fluid, electrical, gas, etc.). The models are designed to simulate software for GSE (Ground Special Power, Crew Access Arm, Cryo, Fire and Leak Detection System, Environmental Control System (ECS), etc. .) before they are implemented into hardware. These models support verifying local control and remote software for End-Item Software Under Test (SUT). The model simulates the physical behavior (function, state, limits and 110) of each end-item and it's dependencies as defined in the Subsystem Interface Table, Software Requirements & Design Specification (SRDS), Ground Integrated Schematic (GIS), and System Mechanical Schematic.(SMS). The software of each specific model component is simulated through MATLAB's Simulink program. The intensiv model development life cycle is a.s follows: Identify source documents; identify model scope; update schedule; preliminary design review; develop model requirements; update model.. scope; update schedule; detailed design review; create/modify library component; implement library components reference; implement subsystem components; develop a test script; run the test script; develop users guide; send model out for peer review; the model is sent out for verifictionlvalidation; if there is empirical data, a validation data package is generated; if there is not empirical data, a verification package is generated; the test results are then reviewed; and finally, the user. requests accreditation, and a statement of accreditation is prepared. Once each component model is reviewed and approved, they are intertwined together into one integrated model. This integrated model is then tested itself, through a test script and autotest, so that it can be concluded that all models work conjointly, for a single purpose. The component I was assigned, specifically, was a fluid component, a discrete pressure switch. The switch takes a fluid pressure input, and if the pressure is greater than a designated cutoff pressure, the switch would stop fluid flow.

Physiologic mechanisms of circulatory and body fluid losses in weightlessness identified by mathematical modeling

NASA Technical Reports Server (NTRS)

Simanonok, K. E.; Srinivasan, R. S.; Charles, J. B.

1993-01-01

Central volume expansion due to fluid shifts in weightlessness is believed to activate adaptive reflexes which ultimately result in a reduction of the total circulating blood volume. However, the flight data suggests that a central volume overdistention does not persist, in which case some other factor or factors must be responsible for body fluid losses. We used a computer simulation to test the hypothesis that factors other than central volume overdistention are involved in the loss of blood volume and other body fluid volumes observed in weightlessness and in weightless simulations. Additionally, the simulation was used to identify these factors. The results predict that atrial volumes and pressures return to their prebedrest baseline values within the first day of exposure to head down tilt (HDT) as the blood volume is reduced by an elevated urine formation. They indicate that the mechanisms for large and prolonged body fluid losses in weightlessness is red cell hemoconcentration that elevates blood viscosity and peripheral resistance, thereby lowering capillary pressure. This causes a prolonged alteration of the balance of Starling forces, depressing the extracellular fluid volume until the hematocrit is returned to normal through a reduction of the red cell mass, which also allows some restoration of the plasma volume. We conclude that the red cell mass becomes the physiologic driver for a large 'undershoot' of the body fluid volumes after the normalization of atrial volumes and pressures.

Fault zone structure and fluid-rock interaction of a high angle normal fault in Carrara marble (NW Tuscany, Italy)

NASA Astrophysics Data System (ADS)

Molli, G.; Cortecci, G.; Vaselli, L.; Ottria, G.; Cortopassi, A.; Dinelli, E.; Mussi, M.; Barbieri, M.

2010-09-01

We studied the geometry, intensity of deformation and fluid-rock interaction of a high angle normal fault within Carrara marble in the Alpi Apuane NW Tuscany, Italy. The fault is comprised of a core bounded by two major, non-parallel slip surfaces. The fault core, marked by crush breccia and cataclasites, asymmetrically grades to the host protolith through a damage zone, which is well developed only in the footwall block. On the contrary, the transition from the fault core to the hangingwall protolith is sharply defined by the upper main slip surface. Faulting was associated with fluid-rock interaction, as evidenced by kinematically related veins observable in the damage zone and fluid channelling within the fault core, where an orange-brownish cataclasite matrix can be observed. A chemical and isotopic study of veins and different structural elements of the fault zone (protolith, damage zone and fault core), including a mathematical model, was performed to document type, role, and activity of fluid-rock interactions during deformation. The results of our studies suggested that deformation pattern was mainly controlled by processes associated with a linking-damage zone at a fault tip, development of a fault core, localization and channelling of fluids within the fault zone. Syn-kinematic microstructural modification of calcite microfabric possibly played a role in confining fluid percolation.

Implications of the effective one-component analysis of pair correlations in colloidal fluids with polydispersity

NASA Astrophysics Data System (ADS)

Pond, Mark J.; Errington, Jeffrey R.; Truskett, Thomas M.

2011-09-01

Partial pair-correlation functions of colloidal suspensions with continuous polydispersity can be challenging to characterize from optical microscopy or computer simulation data due to inadequate sampling. As a result, it is common to adopt an effective one-component description of the structure that ignores the differences between particle types. Unfortunately, whether this kind of simplified description preserves or averages out information important for understanding the behavior of the fluid depends on the degree of polydispersity and can be difficult to assess, especially when the corresponding multicomponent description of the pair correlations is unavailable for comparison. Here, we present a computer simulation study that examines the implications of adopting an effective one-component structural description of a polydisperse fluid. The square-well model that we investigate mimics key aspects of the experimental behavior of suspended colloids with short-range, polymer-mediated attractions. To characterize the partial pair-correlation functions and thermodynamic excess entropy of this system, we introduce a Monte Carlo sampling strategy appropriate for fluids with a large number of pseudo-components. The data from our simulations at high particle concentrations, as well as exact theoretical results for dilute systems, show how qualitatively different trends between structural order and particle attractions emerge from the multicomponent and effective one-component treatments, even with systems characterized by moderate polydispersity. We examine consequences of these differences for excess-entropy based scalings of shear viscosity, and we discuss how use of the multicomponent treatment reveals similarities between the corresponding dynamic scaling behaviors of attractive colloids and liquid water that the effective one-component analysis does not capture.

Tracing time scales of fluid residence and migration in the crust (Invited)

NASA Astrophysics Data System (ADS)

Yokochi, R.; Sturchio, N. C.; Purtschert, R.; Jiang, W.; Lu, Z.; Müller, P.; Yang, G.; Kennedy, B. M.

2013-12-01

Crustal fluids (water, gas and oil) mediate chemical reactions, and they may transport, concentrate or disperse elements in the crust; the fluids are often valuable resources in their own right. In this context, determining the time scales of fluid transport and residence time is essential for understanding geochemical cycle of elements, as well as risk and resource management. Crustal fluids contain stable and radioactive noble gases indigenous to the fluid, which may be of magmatic or atmospheric origin of various ages. In addition, radiogenic and nucleogenic noble gases (both stable and radioactive) are continuously produced by the decay of U, Th and K and related nuclear reactions in the crust at known rates and in known relative proportions. They may be released from their production sites and incorporated into the fluid, acting as natural spikes to trace fluid flow. The concentrations of a noble gas isotope in a crustal fluid in a system devoid of phase separation or mixing varies as a function of decay time and supply from the production sites into the fluids. The release rate of noble gases from the production sites in minerals to the fluid phase may be determined uniquely through the studies of noble gas radionuclides (Yokochi et al., 2012), which is fundamental to the behavior of volatile elements in geochemistry. A pilot study of noble gas radionuclides in an active geothermal system was performed at Yellowstone National Park (Yokochi et al., 2013). Prior studies of the Yellowstone system using stable noble gas isotopes show that the thermal fluids contain a mixture of atmospheric, mantle, and crustal components. Noble gas radionuclide measurements provide new chronometric constraints regarding the subsurface residence times of Yellowstone thermal fluids. Upper limits on deep thermal fluid mean residence times, estimated from 39Ar/40Ar* ratios, range from 118 to 137 kyr for features in the Gibbon and Norris Geyser Basin areas, and are about 16 kyr in Lower Geyser Basin, with the key assumption that the fluid acquires its crustal component of Ar in Quaternary volcanic rock of the Yellowstone caldera. Krypton-81 isotopic abundances in the gas samples yield upper limits on residence time that are consistent with those obtained from 39Ar/40Ar* ratios. Young fluid components can also be determined by krypton-85 concentrations in the extracted gases. Better understanding of the production mechanisms of noble-gas radionuclides in reservoir rocks would significantly decrease the uncertainties in modeling fluid residence times.

Actively controlling coolant-cooled cold plate configuration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chainer, Timothy J.; Parida, Pritish R.

Cooling apparatuses are provided to facilitate active control of thermal and fluid dynamic performance of a coolant-cooled cold plate. The cooling apparatus includes the cold plate and a controller. The cold plate couples to one or more electronic components to be cooled, and includes an adjustable physical configuration. The controller dynamically varies the adjustable physical configuration of the cold plate based on a monitored variable associated with the cold plate or the electronic component(s) being cooled by the cold plate. By dynamically varying the physical configuration, the thermal and fluid dynamic performance of the cold plate are adjusted to, formore » example, optimally cool the electronic component(s), and at the same time, reduce cooling power consumption used in cooling the electronic component(s). The physical configuration can be adjusted by providing one or more adjustable plates within the cold plate, the positioning of which may be adjusted based on the monitored variable.« less

Prophylactic cefazolin in amnioinfusions administered for meconium-stained amniotic fluid.

PubMed Central

Edwards, R K; Duff, P

1999-01-01

OBJECTIVE: To determine if amnioinfusion with an antibiotic solution decreased the rate of clinical chorioamnionitis and puerperal endometritis in patients with meconium-stained amniotic fluid. METHODS: Patients in labor at 36 weeks of gestation or greater with singleton pregnancies and meconium-stained amniotic fluid were randomized to receive either cefazolin, 1 g/1,000 mL, of normal saline (n = 90) or normal saline (n = 93) amnioinfusion. Rates of clinically diagnosed chorioamnionitis and endometritis and of suspected and culture-proven neonatal infection were determined. RESULTS: Between the study and control groups, the incidences of clinical chorioamnionitis (7.8% vs. 8.6%), endometritis (2.4% vs. 3.5%), aggregate intrauterine infection (10.0% vs. 11.8%), suspected neonatal infection (17.8% vs. 21.5%), and proven neonatal infection (0.0% vs. 2.2%) were not significantly different. CONCLUSIONS: Prophylactic use of cefazolin in amnioinfusions did not significantly reduce rates of maternal or neonatal infection in patients with meconium-stained amniotic fluid. PMID:10371474

Influence of the softness of the parietal pleura on respiratory sliding mechanisms

PubMed Central

Kim, Jae Hun; Butler, James P.; Loring, Stephen H.

2011-01-01

The pleural surfaces of the lung and chest wall slide against each other with low friction. Normal load support can be effected either by a combination of quasi-static fluid pressure and solid-solid contacts of relatively stiff asperities, or by shear-induced hydrodynamic pressures in the pleural fluid layer. To distinguish between these mechanisms, we measured surface topography and spatial distribution of stiffness of rat parietal pleura using atomic force microscopy. The topography of the pleural surface has unevenness at length scales smaller than the thickness of pleural fluid, similar to mesothelial cell diameters. The estimated maximum normal contact pressure that could be borne by asperities of the soft pleura is much less than that required to support a substantial difference between pleural fluid pressure and the pleural surface pressure. These results suggest that during sliding motion, unevenness of the pleural surface is smoothed by local hydrodynamic pressure, preventing any significant contribution of solid-solid contacts. PMID:21473935

IGF-I and NEFA concentrations in fetal fluids of term pregnancy dogs.

PubMed

Meloni, Tea; Comin, Antonella; Rota, Alessandro; Peric, Tanja; Contri, Alberto; Veronesi, Maria Cristina

2014-06-01

Insulin-like growth factor-I (IGF-I) and non-esterified fatty acids (NEFA) play an essential role in fetal growth and development. To date, fetal fluids IGF-I and NEFA levels at term canine pregnancy are unknown and could be related to the neonatal development and breed size. For these reasons, the aims of the present study were as follows: (1) to evaluate IGF-I and NEFA concentrations in fetal fluids collected from normally developed and viable newborn puppies born at term of normal pregnancies; (2) to assess possible differences between IGF-I and NEFA levels in amniotic compared with allantoic fluid; (3) to detect possible relationship between breed body size and IGF-I and NEFA amniotic and allantoic concentrations; (4) to evaluate possible differences in IGF-I fetal fluids levels between male and female puppies; and (5) to assess possible correlations between the two hormones in each type of fluid. The study enrolled 25 pure breed bitches submitted to elective Cesarean section at term because of the high risk of dystocia or previous troubles at parturition. At surgery, amniotic and allantoic fluids were collected and assayed for IGF-I and NEFA. IGF-I and NEFA amounts in both amniotic and allantoic fluids of different breed size bitches (small: ≤10 kg; medium: 11-25 kg; large: 26-40 kg) were detected, as well as the effect of gender on IGF-I levels. On a total of 73 amniotic and 76 allantoic samples collected by normal, viable, and mature newborns, the mean IGF-I concentration was significantly higher in amniotic than in allantoic fluid in all three groups, but the amniotic IGF-I levels were significantly lower in small and medium size bitches when compared with large ones. No significant differences were found in allantoic IGF-I concentrations among size groups. A significant effect of the puppy gender on IGF-I content in both fetal fluids was not reported. Regarding NEFA, in all the three groups, the mean NEFA concentration did not significantly differ between amnion and allantois, but in both fetal fluids, higher NEFA levels were detected in samples belonging to small breeds when compared with medium and large. These data strongly indicated that, also in the dog, a relation between fetal fluids IGF-I and NEFA concentrations and breed size exists. Further research is needed to elucidate the possible role of IGF-I and NEFA in the pathologic conditions related to canine fetal growth. Copyright © 2014 Elsevier Inc. All rights reserved.

Clearance of bile and trypsin in rat lungs following aspiration of human gastric fluid

PubMed Central

Leung, Jason H.; Chang, Jui-Chih; Foltz, Emily; Bell, Sadé M.; Pi, Cinthia; Azad, Sassan; Everett, Mary Lou; Holzknecht, Zoie E.; Sanders, Nathan L.; Parker, William; Davis, R. Duane; Keshavjee, Shaf; Lin, Shu S.

2016-01-01

ABSTRACT Purpose: In the clinical setting, there is no reliable tool for diagnosing gastric aspiration. A potential way of diagnosing gastric fluid aspiration entails bronchoalveolar lavage (BAL) with subsequent examination of the BAL fluid for gastric fluid components that are exogenous to the lungs. The objective of this study was to determine the longevity of the gastric fluid components bile and trypsin in the lung, in order to provide an estimate of the time frame in which assessment of these components in the BAL might effectively be used as a measure of aspiration. Materials and Methods: Human gastric fluid (0.5 mg/kg) was infused in the right lung of intubated male Fischer 344 rats (n = 30). Animals were sacrificed at specified times following the experimentally induced aspiration, and bronchoalveolar lavage fluid (BALF) was collected. Bile concentrations were analyzed by an enzyme-linked chromatogenic method, and the concentration of trypsin was quantified using an ELISA. Data were analyzed using non-linear regression and a one-phase decay equation. Results: In this experimental model, the half-life of bile was 9.3 hours (r 2 = 0.81), and the half-life of trypsin was 9.0 hours (r 2 = 0.68). Conclusions: The half-lives of bile and trypsin in the rodent aspiration model suggest that the ability to detect aspiration may be limited to a few days post-aspiration. If studies using rats are any indication, it may be most effective to collect BAL samples within the first 24 hours of suspected aspiration events in order to detect aspiration. PMID:26873328

Clearance of bile and trypsin in rat lungs following aspiration of human gastric fluid.

PubMed

Leung, Jason H; Chang, Jui-Chih; Foltz, Emily; Bell, Sadé M; Pi, Cinthia; Azad, Sassan; Everett, Mary Lou; Holzknecht, Zoie E; Sanders, Nathan L; Parker, William; Davis, R Duane; Keshavjee, Shaf; Lin, Shu S

2016-01-01

In the clinical setting, there is no reliable tool for diagnosing gastric aspiration. A potential way of diagnosing gastric fluid aspiration entails bronchoalveolar lavage (BAL) with subsequent examination of the BAL fluid for gastric fluid components that are exogenous to the lungs. The objective of this study was to determine the longevity of the gastric fluid components bile and trypsin in the lung, in order to provide an estimate of the time frame in which assessment of these components in the BAL might effectively be used as a measure of aspiration. Human gastric fluid (0.5 mg/kg) was infused in the right lung of intubated male Fischer 344 rats (n = 30). Animals were sacrificed at specified times following the experimentally induced aspiration, and bronchoalveolar lavage fluid (BALF) was collected. Bile concentrations were analyzed by an enzyme-linked chromatogenic method, and the concentration of trypsin was quantified using an ELISA. Data were analyzed using non-linear regression and a one-phase decay equation. In this experimental model, the half-life of bile was 9.3 hours (r(2) = 0.81), and the half-life of trypsin was 9.0 hours (r(2) = 0.68). The half-lives of bile and trypsin in the rodent aspiration model suggest that the ability to detect aspiration may be limited to a few days post-aspiration. If studies using rats are any indication, it may be most effective to collect BAL samples within the first 24 hours of suspected aspiration events in order to detect aspiration.

Force characteristics of a modular squeeze mode magneto-rheological element

NASA Astrophysics Data System (ADS)

Craft, Michael J.; Ahmadian, Mehdi; Farjoud, Alireza; Burke, William C. T.; Nagode, Clement

2010-04-01

While few publications exist on the behavior of Magneto-Rheological (MR) fluid in squeeze mode, devices using squeeze mode may take advantage of the very large range of adjustment that squeeze mode offers. Based on results obtained through modeling and testing MR fluid in a squeeze mode rheometer, a novel compression-adjustable element has been fabricated and tested, which utilizes MR fluid in squeeze mode. While shear and valve modes have been used exclusively for MR fluid damping applications, recent modeling and testing with MR fluid has revealed that much larger adjustment ranges are achievable in squeeze mode. Utilizing squeeze mode, a compression element, or MR Pouch, was developed consisting of a flexible cylindrical membrane with each end fastened to a steel endplate (pole plates). The silicone rubber pouch material was molded in the required shape for use in the squeeze mode rheometer. This flexible membrane allows for the complete self-containment of MR fluid and because the pouch compensates for volume changes, there is no need for dynamic seals and associated surface finish treatments on the steel components. An electromagnet incorporated in the rheometer passes an adjustable magnetic field axially through the pole plates and MR fluid. Test results show the device was capable of varying the compression force from less than 8lbs to greater than 1000lbs when the pole plates were 0.050" apart. Simulations were compared against test data with good correlation. Possible applications of this technology include primary suspension components, auxiliary suspension bump stops, and other vibration isolation components, as MR Pouches are scalable depending on the application and force requirements.

Sandstone-filled normal faults: A case study from central California

NASA Astrophysics Data System (ADS)

Palladino, Giuseppe; Alsop, G. Ian; Grippa, Antonio; Zvirtes, Gustavo; Phillip, Ruy Paulo; Hurst, Andrew

2018-05-01

Despite the potential of sandstone-filled normal faults to significantly influence fluid transmissivity within reservoirs and the shallow crust, they have to date been largely overlooked. Fluidized sand, forcefully intruded along normal fault zones, markedly enhances the transmissivity of faults and, in general, the connectivity between otherwise unconnected reservoirs. Here, we provide a detailed outcrop description and interpretation of sandstone-filled normal faults from different stratigraphic units in central California. Such faults commonly show limited fault throw, cm to dm wide apertures, poorly-developed fault zones and full or partial sand infill. Based on these features and inferences regarding their origin, we propose a general classification that defines two main types of sandstone-filled normal faults. Type 1 form as a consequence of the hydraulic failure of the host strata above a poorly-consolidated sandstone following a significant, rapid increase of pore fluid over-pressure. Type 2 sandstone-filled normal faults form as a result of regional tectonic deformation. These structures may play a significant role in the connectivity of siliciclastic reservoirs, and may therefore be crucial not just for investigation of basin evolution but also in hydrocarbon exploration.

Multipurpose Thermal Insulation Test Apparatus

NASA Technical Reports Server (NTRS)

Fesmire, James E. (Inventor); Augustynowicz, Stanislaw D. (Inventor)

2002-01-01

A multi-purpose thermal insulation test apparatus is used for testing insulation materials, or other components. The test apparatus is a fluid boil-off calorimeter system for calibrated measurement of the apparent thermal conductivity (k-value) of a specimen material at a fixed vacuum level. The apparatus includes an inner vessel for receiving a fluid with a normal boiling point below ambient temperature, such as liquid nitrogen, enclosed within a vacuum chamber. A cold mass assembly, including the inner vessel and thermal guards, is suspended from the top of the vacuum chamber. Handling tools attach to the cold mass assembly for convenient manipulation of the assembly and for the installation or wrapping of insulation test materials. Liquid nitrogen is typically supplied to the inner vessel using a fill tube with funnel. A single port through the top of the vacuum chamber facilitates both filling and venting. Aerogel composite stacks with reflective films are fastened to the top and the bottom of the inner vessel as thermal guards. The comparative k-value of the insulation material is determined by measuring the boil-off flow rate of gas, the temperature differential across the insulation thickness, and the dimensions (length and diameters) of the test specimen.

Inhibitory effect of kefiran on ovalbumin-induced lung inflammation in a murine model of asthma.

PubMed

Kwon, Ok-Kyoung; Ahn, Kyung-Seop; Lee, Mee-Young; Kim, So-Young; Park, Bo-Young; Kim, Mi-Kyoung; Lee, In-Young; Oh, Sei-Ryang; Lee, Hyeong-Kyu

2008-12-01

Kefiran is a major component of kefir which is a microbial symbiont mixture that produces jelly-like grains. This study aimed to evaluate the therapeutic availability of kefiran on the ovalbumin-induced asthma mouse model in which airway inflammation and airway hyper-responsiveness were found in the lung. BALB/c mice sensitized and challenged to ovalbumin were treated intra-gastrically with kefiran 1 hour before the ovalbumin challenge. Kefiran significantly suppressed ovalbumin-induced airway hyper-responsiveness (AHR) to inhaled methacholine. Administration of kefiran significantly inhibited the release of both eosinophils and other inflammatory cells into bronchoalveolar lavage (BAL) fluid and lung tissue which was measured by Diff-Quik. Interleukin-4 (IL-4) and interleukin-5 (IL-5) were also reduced to normal levels after administration of kefiran in BAL fluid. Histological studies demonstrate that kefiran substantially inhibited ovalbumin-induced eosinophilia in lung tissue by H&E staining and goblet cell hyperplasia in the airway by PAS staining. Taken above data, kefiran may be useful for the treatment of inflammation of lung tissue and airway hyper-responsiveness in a murine model and may have therapeutic potential for the treatment of allergic bronchial asthma.

Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process.

PubMed

Silva, A F; Sarraguça, M C; Fonteyne, M; Vercruysse, J; De Leersnyder, F; Vanhoorne, V; Bostijn, N; Verstraeten, M; Vervaet, C; Remon, J P; De Beer, T; Lopes, J A

2017-08-07

A multivariate statistical process control (MSPC) strategy was developed for the monitoring of the ConsiGma™-25 continuous tablet manufacturing line. Thirty-five logged variables encompassing three major units, being a twin screw high shear granulator, a fluid bed dryer and a product control unit, were used to monitor the process. The MSPC strategy was based on principal component analysis of data acquired under normal operating conditions using a series of four process runs. Runs with imposed disturbances in the dryer air flow and temperature, in the granulator barrel temperature, speed and liquid mass flow and in the powder dosing unit mass flow were utilized to evaluate the model's monitoring performance. The impact of the imposed deviations to the process continuity was also evaluated using Hotelling's T 2 and Q residuals statistics control charts. The influence of the individual process variables was assessed by analyzing contribution plots at specific time points. Results show that the imposed disturbances were all detected in both control charts. Overall, the MSPC strategy was successfully developed and applied. Additionally, deviations not associated with the imposed changes were detected, mainly in the granulator barrel temperature control. Copyright © 2017 Elsevier B.V. All rights reserved.

Acoustic radiation damping of flat rectangular plates subjected to subsonic flows

NASA Technical Reports Server (NTRS)

Lyle, Karen Heitman

1993-01-01

The acoustic radiation damping for various isotropic and laminated composite plates and semi-infinite strips subjected to a uniform, subsonic and steady flow has been predicted. The predictions are based on the linear vibration of a flat plate. The fluid loading is characterized as the perturbation pressure derived from the linearized Bernoulli and continuity equations. Parameters varied in the analysis include Mach number, mode number and plate size, aspect ratio and mass. The predictions are compared with existing theoretical results and experimental data. The analytical results show that the fluid loading can significantly affect realistic plate responses. Generally, graphite/epoxy and carbon/carbon plates have higher acoustic radiation damping values than similar aluminum plates, except near plate divergence conditions resulting from aeroelastic instability. Universal curves are presented where the acoustic radiation damping normalized by the mass ratio is a linear function of the reduced frequency. A separate curve is required for each Mach number and plate aspect ratio. In addition, acoustic radiation damping values can be greater than or equal to the structural component of the modal critical damping ratio (assumed as 0.01) for the higher subsonic Mach numbers. New experimental data were acquired for comparison with the analytical results.

Blood and urine responses to ingesting fluids of various salt and glucose concentrations. [to combat orthostatic intolerance

NASA Technical Reports Server (NTRS)

Frey, Mary A.; Riddle, Jeanne; Charles, John B.; Bungo, Michael W.

1991-01-01

To compensate for the reduced blood and fluid volumes that develop during weightlessness, the Space Shuttle crewmembers consume salt tablets and water equivalent to 1 l of normal saline, about 2 hrs before landing. This paper compares the effects on blood, urine, and cardiovascular variables of the ingestion of 1 l of normal (0.9 percent) saline with the effects of distilled water, 1 percent glucose, 0.74 percent saline with 1 percent glucose, 0.9 percent saline with 1 percent glucose, and 1.07 percent saline. It was found that the expansion of plasma volume and the concentration of urine were greater 4 hrs after ingestion of 1.07 percent saline solution than after ingestion of normal saline and that the solutions containig glucose did not enhance any variables as compared with normal saline.

Membrane materials for storing biological samples intended for comparative nanotoxicological testing

NASA Astrophysics Data System (ADS)

Metelkin, A.; Kuznetsov, D.; Kolesnikov, E.; Chuprunov, K.; Kondakov, S.; Osipov, A.; Samsonova, J.

2015-11-01

The study is aimed at identifying the samples of most promising membrane materials for storing dry specimens of biological fluids (Dried Blood Spots, DBS technology). Existing sampling systems using cellulose fiber filter paper have a number of drawbacks such as uneven distribution of the sample spot, dependence of the spot spreading area on the individual biosample properties, incomplete washing-off of the sample due to partially inconvertible sorption of blood components on cellulose fibers, etc. Samples of membrane materials based on cellulose, polymers and glass fiber with applied biosamples were studied using methods of scanning electron microscopy, FT-IR spectroscopy and surface-wetting measurement. It was discovered that cellulose-based membrane materials sorb components of biological fluids inside their structure, while membranes based on glass fiber display almost no interaction with the samples and biological fluid components dry to films in the membrane pores between the structural fibers. This characteristic, together with the fact that membrane materials based on glass fiber possess sufficient strength, high wetting properties and good storage capacity, attests them as promising material for dry samples of biological fluids storage systems.

Microfluidics apparatus and methods for use thereof

DOEpatents

Peeters, John P.; Wiggins, Thomas; Ghosh, Madhushree; Bottomley, Lawrence A.; Seminara, Salvatore; Hu, Zhiyu; Seeley, Timothy; Kossek, Sebastian

2005-08-09

A microfluidics device includes a plurality of interaction cells and fluid control means including i) means for providing to the interaction cells a preparation fluid, and ii) means for providing to the interaction cells a sample fluid, wherein each interaction cell receives a different sample fluid. A plurality of microcantilevers may be disposed in each of the interaction cells, wherein each of the plurality of microcantilevers configured to deflect in response to an interaction involving a component of the sample fluid.

Effect of 60 degrees head-down tilt on peripheral gas mixing in the human lung.

PubMed

Olfert, I Mark; Prisk, G Kim

2004-09-01

The phase III slope of sulfur hexafluoride (SF6) in a single-breath washout (SBW) is greater than that of helium (He) under normal gravity (i.e., 1G), thus resulting in a positive SF6-He slope difference. In microgravity (microG), SF6-He slope difference is smaller because of a greater fall in the phase III slope of SF6 than He. We sought to determine whether increasing thoracic fluid volume using 60 degrees head-down tilt (HDT) in 1G would produce a similar effect to microG on phase III slopes of SF6 and He. Single-breath vital capacity (SBW) and multiple-breath washout (MBW) tests were performed before, during, and 60 min after 1 h of HDT. Compared with baseline (SF6 1.050 +/- 0.182%/l, He 0.670 +/- 0.172%/l), the SBW phase III slopes for both SF6 and He tended to decrease during HDT, reaching nadir at 30 min (SF6 0.609 +/- 0.211%/l, He 0.248 +/- 0.138%/l; P = 0.08 and P = 0.06, respectively). In contrast to microG, the magnitude of the phase III slope decrease was similar for both SF6 and He; therefore, no change in SF6-He slope difference was observed. MBW analysis revealed a decrease in normalized phase III slopes at all time points during HDT, for both SF6 (P < 0.01) and He (P < 0.01). This decrease was due to changes in the acinar, and not the conductive, component of the normalized phase III slope. These findings support the notion that changes in thoracic fluid volume alter ventilation distribution in the lung periphery but also demonstrate that the effect during HDT does not wholly mimic that observed in microG.

Systems for column-based separations, methods of forming packed columns, and methods of purifying sample components

DOEpatents

Egorov, Oleg B.; O'Hara, Matthew J.; Grate, Jay W.; Chandler, Darrell P.; Brockman, Fred J.; Bruckner-Lea, Cynthia J.

2000-01-01

The invention encompasses systems for column-based separations, methods of packing and unpacking columns and methods of separating components of samples. In one aspect, the invention includes a method of packing and unpacking a column chamber, comprising: a) packing a matrix material within a column chamber to form a packed column; and b) after the packing, unpacking the matrix material from the column chamber without moving the column chamber. In another aspect, the invention includes a system for column-based separations, comprising: a) a fluid passageway, the fluid passageway comprising a column chamber and a flow path in fluid communication with the column chamber, the flow path being obstructed by a retaining material permeable to a carrier fluid and impermeable to a column matrix material suspended in the carrier fluid, the flow path extending through the column chamber and through the retaining material, the flow path being configured to form a packed column within the column chamber when a suspension of the fluid and the column matrix material is flowed along the flow path; and b) the fluid passageway extending through a valve intermediate the column chamber and the retaining material.

Systems For Column-Based Separations, Methods Of Forming Packed Columns, And Methods Of Purifying Sample Components

DOEpatents

Egorov, Oleg B.; O'Hara, Matthew J.; Grate, Jay W.; Chandler, Darrell P.; Brockman, Fred J.; Bruckner-Lea, Cynthia J.

2006-02-21

The invention encompasses systems for column-based separations, methods of packing and unpacking columns and methods of separating components of samples. In one aspect, the invention includes a method of packing and unpacking a column chamber, comprising: a) packing a matrix material within a column chamber to form a packed column; and b) after the packing, unpacking the matrix material from the column chamber without moving the column chamber. In another aspect, the invention includes a system for column-based separations, comprising: a) a fluid passageway, the fluid passageway comprising a column chamber and a flow path in fluid communication with the column chamber, the flow path being obstructed by a retaining material permeable to a carrier fluid and impermeable to a column matrix material suspended in the carrier fluid, the flow path extending through the column chamber and through the retaining material, the flow path being configured to form a packed column within the column chamber when a suspension of the fluid and the column matrix material is flowed along the flow path; and b) the fluid passageway extending through a valve intermediate the column chamber and the retaining material.

Systems For Column-Based Separations, Methods Of Forming Packed Columns, And Methods Of Purifying Sample Components.

DOEpatents

Egorov, Oleg B.; O'Hara, Matthew J.; Grate, Jay W.; Chandler, Darrell P.; Brockman, Fred J.; Bruckner-Lea, Cynthia J.

2004-08-24

The invention encompasses systems for column-based separations, methods of packing and unpacking columns and methods of separating components of samples. In one aspect, the invention includes a method of packing and unpacking a column chamber, comprising: a) packing a matrix material within a column chamber to form a packed column; and b) after the packing, unpacking the matrix material from the column chamber without moving the column chamber. In another aspect, the invention includes a system for column-based separations, comprising: a) a fluid passageway, the fluid passageway comprising a column chamber and a flow path in fluid communication with the column chamber, the flow path being obstructed by a retaining material permeable to a carrier fluid and impermeable to a column matrix material suspended in the carrier fluid, the flow path extending through the column chamber and through the retaining material, the flow path being configured to form a packed column within the column chamber when a suspension of the fluid and the column matrix material is flowed along the flow path; and b) the fluid passageway extending through a valve intermediate the column chamber and the retaining material.

Fluids of the Lower Crust: Deep Is Different

NASA Astrophysics Data System (ADS)

Manning, Craig E.

2018-05-01

Deep fluids are important for the evolution and properties of the lower continental and arc crust in tectonically active settings. They comprise four components: H2O, nonpolar gases, salts, and rock-derived solutes. Contrasting behavior of H2O-gas and H2O-salt mixtures yields immiscibility and potential separation of phases with different chemical properties. Equilibrium thermodynamic modeling of fluid-rock interaction using simple ionic species known from shallow-crustal systems yields solutions too dilute to be consistent with experiments and resistivity surveys, especially if CO2 is added. Therefore, additional species must be present, and H2O-salt solutions likely explain much of the evidence for fluid action in high-pressure settings. At low salinity, H2O-rich fluids are powerful solvents for aluminosilicate rock components that are dissolved as polymerized clusters. Addition of salts changes solubility patterns, but aluminosilicate contents may remain high. Fluids with Xsalt = 0.05 to 0.4 in equilibrium with model crustal rocks have bulk conductivities of 10‑1.5 to 100 S/m at porosity of 0.001. Such fluids are consistent with observed conductivity anomalies and are capable of the mass transfer seen in metamorphic rocks exhumed from the lower crust.

Vapour loss (``boiling'') as a mechanism for fluid evolution in metamorphic rocks

NASA Astrophysics Data System (ADS)

Trommsdorff, Volkmar; Skippen, George

1986-11-01

The calculation of fluid evolution paths during reaction progress is considered for multicomponent systems and the results applied to the ternary system, CO2-H2O-NaCl. Fluid evolution paths are considered for systems in which a CO2-rich phase of lesser density (vapour) is preferentially removed from the system leaving behind a saline aqueous phase (liquid). Such “boiling” leads to enrichment of the residual aqueous phase in dissolved components and, for certain reaction stoichiometries, to eventual saturation of the fluids in salt components. Distinctive textures, particularly radiating growths of prismatic minerals such as tremolite or diopside, are associated with saline fluid inclusions and solid syngenetic salt inclusions at a number of field localities. The most thoroughly studied of these localities is Campolungo, Switzerland, where metasomatic rocks have developed in association with fractures and veins at 500° C and 2,000 bars of pressure. The petrography of these rocks suggests that fluid phase separation into liquid and vapour has been an important process during metasomatism. Fracture systems with fluids at pressure less than lithostatic may facilitate the loss of the less dense vapour phase to conditions of the amphibolite facies.

Host DNA synthesis-suppressing factor in culture fluid of tissue cultures infected with measles virus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minagawa, T.; Nakaya, C.; Iida, H.

1974-05-01

Host DNA synthesis is suppressed by the culture fluid of cell cultures infected with measles virus. This activity in the culture fluid is initiated somewhat later than the growth of infectious virus. Ninety percent of host DNA synthesis in HeLa cells is inhibited by culture fluid of 3-day-old cell cultures of Vero or HeLa cells infected with measles virus. This suppressing activity is not a property of the virion, but is due to nonvirion-associated componentnent which shows none of the activities of measles virus such as hemagglutination, hemolysis, or cell fusion nor does it have the antigenicity of measles virusmore » as tested by complement-fixation or hemagglutination-inhibiting antibody blocking tests. Neutralization of the activity of this component is not attained with the pooled sera of convalescent measles patients. This component has molecular weights of about 45,000, 20,000, and 3,000 and appears to be a heat-stable protein. The production of host DNA suppressing factor (DSF) is blocked by cycloheximide. Neither uv-inactivated nor antiserum-neutralized measles virus produce DSF. Furthermore, such activity of nonvirion-associated component is not detected in the culture fluid of cultures infected with other RNA viruses such as poliovirus, vesicular stomatitis virus, or Sindbis virus. (auth)« less

Applied Fluid Mechanics. Lecture Notes.

ERIC Educational Resources Information Center

Gregg, Newton D.

This set of lecture notes is used as a supplemental text for the teaching of fluid dynamics, as one component of a thermodynamics course for engineering technologists. The major text for the course covered basic fluids concepts such as pressure, mass flow, and specific weight. The objective of this document was to present additional fluids…

A Simulation for Teaching the Basic and Clinical Science of Fluid Therapy

ERIC Educational Resources Information Center

Rawson, Richard E.; Dispensa, Marilyn E.; Goldstein, Richard E.; Nicholson, Kimberley W.; Vidal, Noni Korf

2009-01-01

The course "Management of Fluid and Electrolyte Disorders" is an applied physiology course taught using lectures and paper-based cases. The course approaches fluid therapy from both basic science and clinical perspectives. While paper cases provide a basis for application of basic science concepts, they lack key components of genuine clinical…

DEVELOPMENT OF NEW DRILLING FLUIDS

DOE Office of Scientific and Technical Information (OSTI.GOV)

David B. Burnett

2003-08-01

The goal of the project has been to develop new types of drill-in fluids (DIFs) and completion fluids (CFs) for use in natural gas reservoirs. Phase 1 of the project was a 24-month study to develop the concept of advanced type of fluids usable in well completions. Phase 1 tested this concept and created a kinetic mathematical model to accurately track the fluid's behavior under downhole conditions. Phase 2 includes tests of the new materials and practices. Work includes the preparation of new materials and the deployment of the new fluids and new practices to the field. The project addressesmore » the special problem of formation damage issues related to the use of CFs and DIFs in open hole horizontal well completions. The concept of a ''removable filtercake'' has, as its basis, a mechanism to initiate or trigger the removal process. Our approach to developing such a mechanism is to identify the components of the filtercake and measure the change in the characteristics of these components when certain cleanup (filtercake removal) techniques are employed.« less

Computational fluid dynamics simulation of pressure and velocity distribution inside Meniere’s diseased vestibular system

NASA Astrophysics Data System (ADS)

Shamsuddin, N. F. H.; Isa, N. M.; Taib, I.; Mohammed, A. N.

2017-09-01

Meniere’s disease or known as endolymphatic hydrops is an incurable vestibular disorder of the inner ear. This is due to the excessive fluid build-up in the endolymphatic sac which causing the vestibular endolymphatic membrane to start stretching. Although this mechanism has been widely accepted as the likely mechanism of Meniere’s syndrome, the reason for its occurrence remains unclear. Thus, the aims of this study to investigate the critical parameters of fluid flow in membranous labyrinth that is influencing instability of vestibular system. In addition, to visualise the flow behaviour between a normal membranous labyrinth and dilated membranous labyrinth in Meniere’s disease in predicting instability of vestibular system. Three dimensional geometry of endolymphatic sac is obtained from Magnetic Resonance Images (MRI) and reconstructed using commercial software. As basis of comparison the two different model of endolymphatic sac is considered in this study which are normal membranous labyrinth for model I and dilated membranous labyrinth for model II. Computational fluid dynamics (CFD) method is used to analyse the behaviour of pressure and velocity flow in the endolymphatic sac. The comparison was made in terms of pressure distribution and velocity profile. The results show that the pressure for dilated membranous labyrinth is greater than normal membranous labyrinth. Due to abnormally pressure in the vestibular system, it leads to the increasing value of the velocity at dilated membranous labyrinth while at the normal membranous labyrinth the velocity values decreasing. As a conclusion by changing the parameters which is pressure and velocity can significantly affect to the instability of vestibular system for Meniere’s disease.

Mobility power flow analysis of an L-shaped plate structure subjected to acoustic excitation

NASA Technical Reports Server (NTRS)

Cuschieri, J. M.

1989-01-01

An analytical investigation based on the Mobility Power Flow method is presented for the determination of the vibrational response and power flow for two coupled flat plate structures in an L-shaped configuration, subjected to acoustical excitation. The principle of the mobility power flow method consists of dividing the global structure into a series of subsystems coupled together using mobility functions. Each separate subsystem is analyzed independently to determine the structural mobility functions for the junction and excitation locations. The mobility functions, together with the characteristics of the junction between the subsystems, are then used to determine the response of the global structure and the power flow. In the coupled plate structure considered here, mobility power flow expressions are derived for excitation by an incident acoustic plane wave. In this case, the forces (acoustic pressures) acting on the structure are dependent on the response of the structure because of the scattered pressure component. The interaction between the structure and the fluid leads to the derivation of a corrected mode shape for the plates' normal surface velocity and also for the structure mobility functions. The determination of the scattered pressure components in the expressions for the power flow represents an additional component in the power flow balance for the source plate and the receiver plate. This component represents the radiated acoustical power from the plate structure.

Mobility power flow analysis of coupled plate structure subjected to mechanical and acoustic excitation

NASA Technical Reports Server (NTRS)

Cuschieri, J. M.

1992-01-01

The mobility power flow approach that was previously applied in the derivation of expressions for the vibrational power flow between coupled plate substructures forming an L configuration and subjected to mechanical loading is generalized. Using the generalized expressions, both point and distributed mechanical loads on one or both of the plates can be considered. The generalized approach is extended to deal with acoustic excitation of one of the plate substructures. In this case, the forces (acoustic pressures) acting on the structure are dependent on the response of the structure because of the scattered pressure component. The interaction between the plate structure and the acoustic fluid leads to the derivation of a corrected mode shape for the plates' normal surface velocity and also for the structure mobility functions. The determination of the scattered pressure components in the expressions for the power flow represents an additional component in the power flow balance for the source plate and the receiver plate. This component represents the radiated acoustical power from the plate structure. For a number of coupled plate substrates, the acoustic pressure generated by one substructure will interact with the motion of another substructure. That is, in the case of the L-shaped plate, acoustic interaction exists between the two plate substructures due to the generation of the acoustic waves by each of the substructures. An approach to deal with this phenomena is described.

The impact of fluid topology on residual saturations - A pore-network model study

NASA Astrophysics Data System (ADS)

Doster, F.; Kallel, W.; van Dijke, R.

2014-12-01

In two-phase flow in porous media only fractions of the resident fluid are mobilised during a displacement process and, in general, a significant amount of the resident fluid remains permanently trapped. Depending on the application, entrapment is desirable (geological carbon storage), or it should be obviated (enhanced oil recovery, contaminant remediation). Despite its utmost importance for these applications, predictions of trapped fluid saturations for macroscopic systems, in particular under changing displacement conditions, remain challenging. The models that aim to represent trapping phenomena are typically empirical and require tracking of the history of the state variables. This exacerbates the experimental verification and the design of sophisticated displacement technologies that enhance or impede trapping. Recently, experiments [1] have suggested that a macroscopic normalized Euler number, quantifying the topology of fluid distributions, could serve as a parameter to predict residual saturations based on state variables. In these experiments the entrapment of fluids was visualised through 3D micro CT imaging. However, the experiments are notoriously time consuming and therefore only allow for a sparse sampling of the parameter space. Pore-network models represent porous media through an equivalent network structure of pores and throats. Under quasi-static capillary dominated conditions displacement processes can be modeled through simple invasion percolation rules. Hence, in contrast to experiments, pore-network models are fast and therefore allow full sampling of the parameter space. Here, we use pore-network modeling [2] to critically investigate the knowledge gained through observing and tracking the normalized Euler number. More specifically, we identify conditions under which (a) systems with the same saturations but different normalized Euler numbers lead to different residual saturations and (b) systems with the same saturations and the same normalized Euler numbers but different process histories yield the same residual saturations. Special attention is given to contact angle and process histories with varying drainage and imbibition periods. [1] Herring et al., Adv. Water. Resour., 62, 47-58 (2013) [2] Ryazanov et al., Transp. Porous Media, 80, 79-99 (2009).

Sodium, phosphate, glucose, bicarbonate, and alanine interactions in the isolated proximal convoluted tubule of the rabbit kidney.

PubMed

Dennis, V W; Brazy, P C

1978-08-01

Interactions among the transport systems involved with sodium, bicarbonate, glucose, phosphate, and alanine absorption in isolated segments of the rabbit proximal convoluted tubule were examined with radioisotopic techniques to measure glucose, phosphate, and fluid absorption rates. The composition of the perfusate and bath varied from normal, physiological fluids to fluids deficient in a single solute. The deletion of glucose from the perfusate increased the lumen-to-bath flux of phosphate from 5.51 +/- 1.15 to 8.32 +/- 1.34 pmol/mm-min (P less than 0.01). Similar changes occurred when glucose transport was inhibited by phlorizin 10 micron in the perfusate, The deletion of alanine from the perfusate increased the lumen-to-bath flux of phosphate from 6.55 +/- 1.08 to 9.00 +/- 1.30 pmol/mm-min (P less than 0.01) but did not affect glucose transport significantly, 80.1 +/- 10.1 vs. 72.5 +/- 5.4 pmol/mm-min. Replacement of intraluminal sodium with choline, elimination of potassium from the bath, and removal of bicarbonate from the lumen and bath each reduced glucose, phosphate, and fluid absorption. These data indicate that the proximal absorptive processes for glucose and for phosphate include elements that are dependent upon some function of sodium transport. Additionally, the effects on phosphate transport of deleting glucose or alanine occur independent of any changes in net sodium transport and are opposite the effects of deleting bicarbonate. These differences may relate to the observations that the transport of glucose and alanine is electrogenic while that of bicarbonate is not. Regardless of possible mechanisms, the data demonstrate that important changes in the absorption rates of different solutes handled significantly by the proximal convoluted tubule may occur in response to changes in specific components of proximal sodium transport.

The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components

PubMed Central

Wiig, Helge; Gyenge, Christina C; Tenstad, Olav

2005-01-01

Knowledge of macromolecular distribution volumes is essential in understanding fluid transport within normal and pathological tissues. In this study in vivo we determined the distribution volumes of several macromolecules, including one monoclonal antibody, in tumours and tested whether charges associated with the tumour extracellular matrix influence their available volumes. Steady state levels of the monoclonal antibody trastuzumab (Herceptin) (pI = 9.2), IgG (pI = 7.6) as well as native (pI = 5.0) and cationized albumin (pI = 7.6) were established in rats bearing dimethylbenzanthracene (DMBA)-induced mammary tumours by continuous infusion using osmotic minipumps. After a 5–7 day infusion period, the rats were nephrectomized and the extracellular volume was determined with 51Cr-labelled EDTA. Plasma volumes were measured with 125I-labelled human serum albumin or rat IgM in a separate series. Steady state concentrations of probes were determined in the interstitial fluid that was isolated by centrifugation from tumours or by post mortem wick implantation in the back skin. Calculations were made for interstitial fluid volume (Vi), along with the available (Va/Vi) and excluded (Ve/Vi) relative interstitial volume fractions. The Ve/Vi for the positively charged trastuzumab in tumours averaged 0.29 ± 0.03 (n = 16), a value which was significantly lower than the corresponding one for IgG of 0.36 ± 0.02 (n = 16). Native albumin was excluded from 38% of the tumour interstitial fluid, whereas cationization of albumin reduced the excluded volume by ∼50%. Our experiments suggest that the tumour interstitium acts as a negatively charged matrix and is an important factor in determining the macromolecular distribution volume. PMID:15994186

The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components.

PubMed

Wiig, Helge; Gyenge, Christina C; Tenstad, Olav

2005-09-01

Knowledge of macromolecular distribution volumes is essential in understanding fluid transport within normal and pathological tissues. In this study in vivo we determined the distribution volumes of several macromolecules, including one monoclonal antibody, in tumours and tested whether charges associated with the tumour extracellular matrix influence their available volumes. Steady state levels of the monoclonal antibody trastuzumab (Herceptin) (pI = 9.2), IgG (pI = 7.6) as well as native (pI = 5.0) and cationized albumin (pI = 7.6) were established in rats bearing dimethylbenzanthracene (DMBA)-induced mammary tumours by continuous infusion using osmotic minipumps. After a 5-7 day infusion period, the rats were nephrectomized and the extracellular volume was determined with 51Cr-labelled EDTA. Plasma volumes were measured with 125I-labelled human serum albumin or rat IgM in a separate series. Steady state concentrations of probes were determined in the interstitial fluid that was isolated by centrifugation from tumours or by post mortem wick implantation in the back skin. Calculations were made for interstitial fluid volume (Vi), along with the available (Va/Vi) and excluded (Ve/Vi) relative interstitial volume fractions. The Ve/Vi for the positively charged trastuzumab in tumours averaged 0.29 +/- 0.03 (n = 16), a value which was significantly lower than the corresponding one for IgG of 0.36 +/- 0.02 (n = 16). Native albumin was excluded from 38% of the tumour interstitial fluid, whereas cationization of albumin reduced the excluded volume by approximately 50%. Our experiments suggest that the tumour interstitium acts as a negatively charged matrix and is an important factor in determining the macromolecular distribution volume.

Childhood Psychosis and Monoamine Metabolites in Spinal Fluid.

ERIC Educational Resources Information Center

Gillberg, Christopher; And Others

1983-01-01

Analysis of cerebrospinal fluid of 22 psychotic children, 22 normal controls, and Ss with mental retardation, progressive encephalopathy, or meningitis revealed that psychotic Ss had raised levels of homovanillic acid. Thirteen Ss diagnosed as autistic showed isolated inrease of this metabolite. Increased concentration of mongamines was not…

Analysis of the essential oils of Alpiniae Officinarum Hance in different extraction methods

NASA Astrophysics Data System (ADS)

Yuan, Y.; Lin, L. J.; Huang, X. B.; Li, J. H.

2017-09-01

It was developed for the analysis of the essential oils of Alpiniae Officinarum Hance extracted by steam distillation (SD), ultrasonic assisted solvent extraction (UAE) and supercritical fluid extraction (SFE) via gas chromatography mass spectrometry (GC-MS) combined with retention index (RI) method. There were multiple volatile components of the oils extracted by the three above-mention methods respectively identified; meanwhile, each one was quantified by area normalization method. The results indicated that the content of 1,8-Cineole, the index constituent, by SD was similar as SFE, and higher than UAE. Although UAE was less time consuming and consumed less energy, the oil quality was poorer due to the use of organic solvents was hard to degrade. In addition, some constituents could be obtained by SFE but could not by SD. In conclusion, essential oil of different extraction methods from the same batch of materials had been proved broadly similarly, however, there were some differences in composition and component ratio. Therefore, development and utilization of different extraction methods must be selected according to the functional requirements of products.

Kinematics of red cell aspiration by fluorescence-imaged microdeformation.

PubMed

Discher, D E; Mohandas, N

1996-10-01

Maps of fluorescing red cell membrane components on a pipette-aspirated projection are quantitated in an effort to elucidate and unify the heterogeneous kinematics of deformation. Transient gradients of diffusing fluorescent lipid first demonstrate the fluidity of an otherwise uniform-density bilayer and corroborate a "universal" calibration scale for relative surface density. A steep but smooth and stable gradient in the densities of the skeleton components spectrin, actin, and protein 4.1 is used to estimate large elastic strains along the aspirated skeleton. The deformation fields are argued to be an unhindered response to loading in the surface normal direction. Density maps intermediate to those of the compressible skeleton and fluid bilayer are exhibited by particular transmembrane proteins (e.g., Band 3) and yield estimates for the skeleton-connected fractions. Such connected proteins appear to occupy a significant proportion of the undeformed membrane surface and can lead to steric exclusion of unconnected integral membrane proteins from regions of network condensation. Consistent with membrane repatterning kinematics in reversible deformation, final vesiculation of the projection tip produces a cell fragment concentrated in freely diffusing proteins but depleted of skeleton.

Physical modelling of LNG rollover in a depressurized container filled with water

NASA Astrophysics Data System (ADS)

Maksim, Dadonau; Denissenko, Petr; Hubert, Antoine; Dembele, Siaka; Wen, Jennifer

2015-11-01

Stable density stratification of multi-component Liquefied Natural Gas causes it to form distinct layers, with upper layer having a higher fraction of the lighter components. Heat flux through the walls and base of the container results in buoyancy-driven convection accompanied by heat and mass transfer between the layers. The equilibration of densities of the top and bottom layers, normally caused by the preferential evaporation of Nitrogen, may induce an imbalance in the system and trigger a rapid mixing process, so-called rollover. Numerical simulation of the rollover is complicated and codes require validation. Physical modelling of the phenomenon has been performed in a water-filled depressurized vessel. Reducing gas pressure in the container to levels comparable to the hydrostatic pressure in the water column allows modelling of tens of meters industrial reservoirs using a 20 cm laboratory setup. Additionally, it allows to model superheating of the base fluid layer at temperatures close the room temperature. Flow visualizations and parametric studies are presented. Results are related to outcomes of numerical modelling.

Tumor-Derived Exosomes and Their Role in Cancer Progression.

PubMed

Whiteside, Theresa L

2016-01-01

Tumor cells actively produce, release, and utilize exosomes to promote tumor growth. Mechanisms through which tumor-derived exosomes subserve the tumor are under intense investigation. These exosomes are information carriers, conveying molecular and genetic messages from tumor cells to normal or other abnormal cells residing at close or distant sites. Tumor-derived exosomes are found in all body fluids. Upon contact with target cells, they alter phenotypic and functional attributes of recipients, reprogramming them into active contributors to angiogenesis, thrombosis, metastasis, and immunosuppression. Exosomes produced by tumors carry cargos that in part mimic contents of parent cells and are of potential interest as noninvasive biomarkers of cancer. Their role in inhibiting the host antitumor responses and in mediating drug resistance is important for cancer therapy. Tumor-derived exosomes may interfere with cancer immunotherapy, but they also could serve as adjuvants and antigenic components of antitumor vaccines. Their biological roles in cancer development or progression as well as cancer therapy suggest that tumor-derived exosomes are critical components of oncogenic transformation. © 2016 Elsevier Inc. All rights reserved.

Gas-sensing optrode

DOEpatents

Hirschfeld, T.B.

1988-04-12

An optrode is provided for sensing dissolved gases or volatile components of a solution. A fiber optic is provided through which light from an associated light source is transmitted from a first end to a second end. A bubble forming means, such as a tube, is attached to the second end of the fiber optic, and an indicator material is disposed in cooperation with the bubble forming means adjacent to the second end of the fiber optic such that it is illuminated by light emanating from the second end. The bubble forming means causes a gas bubble to form whenever the optrode is immersed in the fluid. The gas bubble separates the indicator material from the fluid. Gases, or other volatile components, of the fluid are sensed as they diffuse across the gas bubble from the fluid to the indicator material. 3 figs.

Efficiency of magnetorheological fluid finishing on the elimination of defects in fused silica optics

NASA Astrophysics Data System (ADS)

Catrin, R.; Taroux, D.; Cormont, P.; Maunier, C.; Corbineau, T.; Razé, G.; Néauport, J.

2013-09-01

The MegaJoule laser being constructed at the CEA near Bordeaux (France) is designed to focus more than 1 MJ of energy of UV light, on a millimeter scale target in the centre of an experiment chamber. After amplification and transport at the wavelength of 1053 nm, frequency conversion at 351 nm is done with KH2PO4 crystals. The final optic assembly of this system is made up of large fused silica optics, working in transmission, that are used to convey, focus or shape the laser beam. When exposed to fluences of some joules per square centimeter at 351 nm within nanosecond pulse duration, fused silica optics can exhibit localized damage. Damage sites grow exponentially after further laser exposition and therefore dramatically limit the optic lifetime. The nature of the surface finishing process has been established to determine the lifetime of these components under high UV fluences (i.e. more than 5 J/cm2 for 3 ns pulses). Being able to reduce or eliminate the damage initiators such as subsurface cracks present in subsurface damage (SSD) layer of conventionally polished optical components aims this study. Magneto-rheological fluid finishing (MRF) is chosen as a final polishing tool to remove layers of material without inducing further damages. MRF enables to process optics with very small normal stresses applied to the surface during material removal and thus permits the elimination of the residual subsurface cracks. This study offers a better understanding of the efficiency of MRF polishing on the elimination of subsurface cracks in SSD layers.

The assessment of potentially interfering metabolites and dietary components in blood using an osmotic glucose sensor based on the concanavalin A-dextran affinity assay.

PubMed

Krushinitskaya, Olga; Tønnessen, Tor Inge; Jakobsen, Henrik; Johannessen, Erik

2011-10-15

Continuous surveillance of blood glucose is a prerogative of maintaining a tight glycaemic control in people suffering from diabetes mellitus. Implantable sensor technology offers the potential of conducting direct long term continuous glucose measurements, but current size restrictions and operational challenges have limited their applications. The osmotic sensor utilises diffusion to create a hydrostatic pressure that is independent of sensor operation and power consumption. This permits ultra-low power architectures to be realized with a minimal start-up time in a package suitable for miniaturization. In contrast, osmotic sensors suffer from the inability of their membranes to discriminate between different constituents in blood or the interstitial fluid that are of comparable size to glucose. By implementing an affinity assay based on the competitive bonding between concanavalin A and dextran, the selectivity of the membrane can be transferred to the glucose specific recognition of the affinity assay. The osmotic effect from the physiological levels of several key metabolites and nutritional components has been addressed identifying in particular ethanol, lactate and amino acids as potential interfering constituents. Both ascorbic acid and mannose would have a normal physiological concentration that is too low to be detected. The studies shows that an osmotic glucose sensor equipped with the con A-dextran affinity assay, is able to filter out potential interfering constituents present in blood, plasma and the interstitial fluid yet retaining a pressure that is proportional to glucose only. Copyright © 2011 Elsevier B.V. All rights reserved.

An optimized index of human cardiovascular adaptation to simulated weightlessness

NASA Technical Reports Server (NTRS)

Wang, M.; Hassebrook, L.; Evans, J.; Varghese, T.; Knapp, C.

1996-01-01

Prolonged exposure to weightlessness is known to produce a variety of cardiovascular changes, some of which may influence the astronaut's performance during a mission. In order to find a reliable indicator of cardiovascular adaptation to weightlessness, we analyzed data from nine male subjects after a 24-hour period of normal activity and after a period of simulated weightlessness produced by two hours in a launch position followed by 20 hours of 6 degrees head-down tilt plus pharmacologically induced diuresis (furosemide). Heart rate, arterial pressure, thoracic fluid index, and radial flow were analyzed. Autoregressive spectral estimation and decomposition were used to obtain the spectral components of each variable from the subjects in the supine position during pre- and post-simulated weightlessness. We found a significant decrease in heart rate power and an increase in thoracic fluid index power in the high frequency region (0.2-0.45 Hz) and significant increases in radial flow and arterial pressure powers in the low frequency region (<0.2 Hz) in response to simulated weightlessness. However, due to the variability among subjects, any single variable appeared limited as a dependable index of cardiovascular adaptation to weightlessness. The backward elimination algorithm was then used to select the best discriminatory features from these spectral components. Fisher's linear discriminant and Bayes' quadratic discriminant were used to combine the selected features to obtain an optimal index of adaptation to simulated weightlessness. Results showed that both techniques provided improved discriminant performance over any single variable and thus have the potential for use as an index to track adaptation and prescribe countermeasures to the effects of weightlessness.

Engineering test results for the Moog Single Line Disconnect

NASA Technical Reports Server (NTRS)

Glubke, Scott E.

1990-01-01

New and innovative types of disconnects will be required to service, resupply, and maintain future spacecraft subsystems. Efficiently maintaining orbiting scientific instruments, spacecraft support systems, and a manned space station over a long period of time will require the periodic replenishment of consumables and the replacement of components. To accomplish these tasks, the fluid disconnect must be designed to allow the connection and separation of fluid lines and components with minimal hazard to crew and equipment. The capability to simply connect a refueling line or to easily replace a failed component greatly extends the life of a space based fluid system. A test program was initiated to evaluate the Moog Single Line Disconnect. The objective of the test program was to demonstrate the operational characteristics of the disconnect and to verify compliance with current safety regulations. The results of the program are summarized in the referenced document.

Translator for Optimizing Fluid-Handling Components

NASA Technical Reports Server (NTRS)

Landon, Mark; Perry, Ernest

2007-01-01

A software interface has been devised to facilitate optimization of the shapes of valves, elbows, fittings, and other components used to handle fluids under extreme conditions. This software interface translates data files generated by PLOT3D (a NASA grid-based plotting-and- data-display program) and by computational fluid dynamics (CFD) software into a format in which the files can be read by Sculptor, which is a shape-deformation- and-optimization program. Sculptor enables the user to interactively, smoothly, and arbitrarily deform the surfaces and volumes in two- and three-dimensional CFD models. Sculptor also includes design-optimization algorithms that can be used in conjunction with the arbitrary-shape-deformation components to perform automatic shape optimization. In the optimization process, the output of the CFD software is used as feedback while the optimizer strives to satisfy design criteria that could include, for example, improved values of pressure loss, velocity, flow quality, mass flow, etc.

Influence of D-Penicillamine on the Viscosity of Hyaluronic Acid Solutions

NASA Astrophysics Data System (ADS)

Liang, Jing; Krause, Wendy E.; Colby, Ralph H.

2006-03-01

Polyelectrolyte hyaluronic acid (HA, hyaluronan) is an important component in synovial fluid. Its presence results in highly viscoelastic solutions with excellent lubricating and shock-absorbing properties. In comparison to healthy synovial fluid, diseased fluid has a reduced viscosity. In osteoarthritis this reduction in viscosity results from a decline in both the molecular weight and concentration of hyaluronic acid HA. Initial results indicate that D-penicillamine affects the rheology of bovine synovial fluid, a model synovial fluid solution, and its components, including HA. In order to understand how D-penicillamine modifies the viscosity of these solutions, the rheological properties of sodium hyaluronate (NaHA) in phosphate-buffered saline (PBS) with D-penicillamine were studied as function of time, D-penicillamine concentration (0 -- 0.01 M), and storage conditions. Penicillamine has a complex, time dependent effect on the viscosity of NaHA solutions---reducing the zero shear rate viscosity of a 3 mg/mL NaHA in PBS by ca. 40% after 44 days.

Increased concentrations of bone sialoprotein in joint fluid after knee injury.

PubMed Central

Lohmander, L S; Saxne, T; Heinegård, D

1996-01-01

OBJECTIVE: To detect evidence for localised changes in bone matrix metabolism after joint trauma and in post-traumatic osteoarthritis by quantification of bone sialoprotein in joint fluid and serum after knee injury in a cross sectional study. METHODS: Samples of knee joint fluid and serum were obtained from volunteers with normal knees (n = 19), patients with rupture of the anterior cruciate ligament isolated or combined with tear of a meniscus (n = 114), and patients with isolated meniscus lesions (n = 80). Concentrations of bone sialoprotein were determined by ELISA. Concentrations of other markers of joint tissue metabolism in these samples were determined in previous investigations. RESULTS: The median concentrations of bone sialoprotein in joint fluid from healthy volunteers was 122 ng ml-1 (range 41 to 183). Concentrations of bone sialoprotein were increased in both injury groups compared with the reference group (median for cruciate ligament injury 146 ng ml-1, range 72 to 339; median for meniscus injury 166 ng ml-1, range 75 to 376). After injury, bone sialoprotein increased quickly and remained increased for six months. Bone sialoprotein in joint fluid was increased only in samples from joints with normal or nearly normal (fibrillated) cartilage, and was within reference range in joints with radiographic signs of osteoarthritis. Bone sialoprotein concentrations in joints with cruciate ligament injury were positively correlated with levels of aggrecan and cartilage oligomeric matrix protein fragments, and with levels of stromelysin-1 and tissue inhibitor of metalloproteinase-1. The ratios between the concentrations of bone sialoprotein in joint fluid and serum were > 1 in the majority of the cruciate ligament injury cases. CONCLUSIONS: The release of significant amounts of bone sialoprotein into joint fluid in connection with acute joint trauma may be associated with injury to, and active remodelling of, the cartilage-bone interface and subchondral bone. The findings are consistent with dramatic shifts in cartilage, bone, and synovial metabolism following joint injury. Bone sialoprotein concentrations in synovial fluid may be a useful marker of subchondral injury and remodelling following joint injury. PMID:8882132

Cotton and Protein Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goheen, Steven C.; Edwards, J. V.; Rayburn, Alfred R.

The adsorbent properties of important wound fluid proteins and cotton cellulose are reviewed. This review focuses on the adsorption of albumin to cotton-based wound dressings and some chemically modified derivatives targeted for chronic wounds. Adsorption of elastase in the presence of albumin was examined as a model to understand the interactive properties of these wound fluid components with cotton fibers. In the chronic non-healing wound, elastase appears to be over-expressed, and it digests tissue and growth factors, interfering with the normal healing process. Albumin is the most prevalent protein in wound fluid, and in highly to moderately exudative wounds, itmore » may bind significantly to the fibers of wound dressings. Thus, the relative binding properties of both elastase and albumin to wound dressing fibers are of interest in the design of more effective wound dressings. The present work examines the binding of albumin to two different derivatives of cotton, and quantifies the elastase binding to the same derivatives following exposure of albumin to the fiber surface. An HPLC adsorption technique was employed coupled with a colorimetric enzyme assay to quantify the relative binding properties of albumin and elastase to cotton. The results of wound protein binding are discussed in relation to the porosity and surface chemistry interactions of cotton and wound proteins. Studies are directed to understanding the implications of protein adsorption phenomena in terms of fiber-protein models that have implications for rationally designing dressings for chronic wounds.« less

Shallow fluid pressure transients caused by seismogenic normal faults

NASA Astrophysics Data System (ADS)

Fleischmann, Karl Henry

1993-10-01

Clastic dikes, induced by paleo-seismic slip along the Jonesboro Fault, can be used to estimate the magnitude of shallow fluid pressure transients. Fractures show evidence of two phases of seismically induced dilation by escaping fluids. Initial dilation and propagation through brittle rocks was caused by expulsion of trapped reducing fluids from beneath a clay cap. Second phase fluids were thixotropic clays which flowed vertically from clay beds upwards into the main fracture. Using the differential dilation and fracture trace lengths, the fluid pressure pulse is estimated to have ranged from 0.312-0.49 MPa, which is approximately equal to the vertical load during deformation. Field observations in adjacent rocks record evidence of large-magnitude seismic events, which are consistent with the large nature of the fluid pressure fluctuation.

Assay of mucins in human tear fluid.

PubMed

Spurr-Michaud, Sandra; Argüeso, Pablo; Gipson, Ilene

2007-05-01

Mucin genes, both secreted (MUC2, MUC5AC, MUC5B, MUC7) and membrane associated (MUC1, MUC4, MUC16), have been reported to be expressed by ocular surface epithelia. The purpose of this study was to comprehensively assay the mucin content of human tear fluid using multiple antibodies for each mucin and to develop a sensitive, semi-quantitative method for the assay of mucins in tears. Tear washes were obtained by instillation of saline onto the ocular surface, followed by collection from the inferior fornix. Tear proteins were separated in 1% agarose gels, transferred to nitrocellulose membrane by vacuum blotting and probed with multiple antibodies recognizing MUC1, MUC2, MUC4, MUC5AC, MUC5B, MUC7 and MUC16. Binding was detected using chemiluminescence, and quantity was determined by densitometry. Serial dilutions of pooled tears from normal individuals were assayed to determine the linear range of detectability. MUC1, MUC4, MUC16, MUC5AC and low levels of MUC2 were consistently detected in human tear fluid, while MUC5B and MUC7 were not. Use of several antibodies recognizing different epitopes on the same mucin confirmed these findings. The antibodies to mucins bound to serial dilutions of tears in a linear fashion (r2 > 0.9), indicating the feasibility of semi-quantitation. MUC5AC in tear fluid had an increased electrophoretic mobility compared to MUC5AC isolated from conjunctival tissue. This study provides clear evidence that the mucin component of tears is a mixture of secreted and shed membrane-associated mucins, and for the first time demonstrates MUC16 in tear fluid. Immunoblots of tears using agarose gel electrophoresis and chemiluminescence detection provide a semi-quantitative assay for mucin protein that will be useful for comparisons with tears from diseased eyes or after pharmacological intervention.

Assay of Mucins in Human Tear Fluid

PubMed Central

Spurr-Michaud, Sandra; Argüeso, Pablo; Gipson, Ilene

2007-01-01

Mucin genes, both secreted (MUC2, MUC5AC, MUC5B, MUC7) and membrane associated (MUC1, MUC4, MUC16), have been reported to be expressed by ocular surface epithelia. The purpose of this study was to comprehensively assay the mucin content of human tear fluid using multiple antibodies for each mucin and to develop a sensitive, semi-quantitative method for the assay of mucins in tears. Tear washes were obtained by instillation of saline onto the ocular surface, followed by collection from the inferior fornix. Tear proteins were separated in 1% agarose gels, transferred to nitrocellulose membrane by vacuum blotting and probed with multiple antibodies recognizing MUC1, MUC2, MUC4, MUC5AC, MUC5B, MUC7 and MUC16. Binding was detected using chemiluminescence, and quantity was determined by densitometry. Serial dilutions of pooled tears from normal individuals were assayed to determine the linear range of detectability. MUC1, MUC4, MUC16, MUC5AC and low levels of MUC2 were consistently detected in human tear fluid, while MUC5B and MUC7 were not. Use of several antibodies recognizing different epitopes on the same mucin confirmed these findings. The antibodies to mucins bound to serial dilutions of tears in a linear fashion (r2 >0.9), indicating the feasibility of semi-quantitation. MUC5AC in tear fluid had an increased electrophoretic mobility compared to MUC5AC isolated from conjunctival tissue. This study provides clear evidence that the mucin component of tears is a mixture of secreted and shed membrane-associated mucins, and for the first time demonstrates MUC16 in tear fluid. Immunoblots of tears using agarose gel electrophoresis and chemiluminescence detection provide a semi-quantitative assay for mucin protein that will be useful for comparisons with tears from diseased eyes or after pharmacological intervention. PMID:17399701

Clinically severe Epstein-Barr virus encephalitis with mild cerebrospinal fluid abnormalities in an immunocompetent adolescent: a case report.

PubMed

Engelmann, Ilka; Nasser, Hala; Belmiloudi, Soufien; Le Guern, Rémi; Dewilde, Anny; Vallée, Louis; Hober, Didier

2013-06-01

A 15-year-old boy developed Epstein-Barr virus (EBV) encephalitis, a rare complication of infectious mononucleosis. The severe clinical picture and the marked neuroimaging changes were in contrast with mild cerebrospinal fluid abnormalities: leukocyte count was normal and protein level was only slightly elevated. EBV DNA was detected in cerebrospinal fluid by polymerase chain reaction. Copyright © 2013 Elsevier Inc. All rights reserved.

The effect of interstitial pressure on therapeutic agent transport: coupling with the tumor blood and lymphatic vascular systems.

PubMed

Wu, Min; Frieboes, Hermann B; Chaplain, Mark A J; McDougall, Steven R; Cristini, Vittorio; Lowengrub, John S

2014-08-21

Vascularized tumor growth is characterized by both abnormal interstitial fluid flow and the associated interstitial fluid pressure (IFP). Here, we study the effect that these conditions have on the transport of therapeutic agents during chemotherapy. We apply our recently developed vascular tumor growth model which couples a continuous growth component with a discrete angiogenesis model to show that hypertensive IFP is a physical barrier that may hinder vascular extravasation of agents through transvascular fluid flux convection, which drives the agents away from the tumor. This result is consistent with previous work using simpler models without blood flow or lymphatic drainage. We consider the vascular/interstitial/lymphatic fluid dynamics to show that tumors with larger lymphatic resistance increase the agent concentration more rapidly while also experiencing faster washout. In contrast, tumors with smaller lymphatic resistance accumulate less agents but are able to retain them for a longer time. The agent availability (area-under-the curve, or AUC) increases for less permeable agents as lymphatic resistance increases, and correspondingly decreases for more permeable agents. We also investigate the effect of vascular pathologies on agent transport. We show that elevated vascular hydraulic conductivity contributes to the highest AUC when the agent is less permeable, but to lower AUC when the agent is more permeable. We find that elevated interstitial hydraulic conductivity contributes to low AUC in general regardless of the transvascular agent transport capability. We also couple the agent transport with the tumor dynamics to simulate chemotherapy with the same vascularized tumor under different vascular pathologies. We show that tumors with an elevated interstitial hydraulic conductivity alone require the strongest dosage to shrink. We further show that tumors with elevated vascular hydraulic conductivity are more hypoxic during therapy and that the response slows down as the tumor shrinks due to the heterogeneity and low concentration of agents in the tumor interior compared with the cases where other pathological effects may combine to flatten the IFP and thus reduce the heterogeneity. We conclude that dual normalizations of the micronevironment - both the vasculature and the interstitium - are needed to maximize the effects of chemotherapy, while normalization of only one of these may be insufficient to overcome the physical resistance and may thus lead to sub-optimal outcomes. Copyright © 2014 Elsevier Ltd. All rights reserved.

The effect of interstitial pressure on therapeutic agent transport: coupling with the tumor blood and lymphatic vascular systems

PubMed Central

Wu, Min; Frieboes, Hermann B.; Chaplain, Mark A.J.; McDougall, Steven R.; Cristini, Vittorio; Lowengrub, John

2014-01-01

Vascularized tumor growth is characterized by both abnormal interstitial fluid flow and the associated interstitial fluid pressure (IFP). Here, we study the effect that these conditions have on the transport of therapeutic agents during chemotherapy. We apply our recently developed vascular tumor growth model which couples a continuous growth component with a discrete angiogenesis model to show that hypertensive IFP is a physical barrier that may hinder vascular extravasation of agents through transvascular fluid flux convection, which drives the agents away from the tumor. This result is consistent with previous work using simpler models without blood flow or lymphatic drainage. We consider the vascular/interstitial/lymphatic fluid dynamics to show that tumors with larger lymphatic resistance increase the agent concentration more rapidly while also experiencing faster washout. In contrast, tumors with smaller lymphatic resistance accumulate less agents but are able to retain them for a longer time. The agent availability (area-under-the curve, or AUC) increases for less permeable agents as lymphatic resistance increases, and correspondingly decreases for more permeable agents. We also investigate the effect of vascular pathologies on agent transport. We show that elevated vascular hydraulic conductivity contributes to the highest AUC when the agent is less permeable, but leads to lower AUC when the agent is more permeable. We find that elevated interstitial hydraulic conductivity contributes to low AUC in general regardless of the transvascular agent transport capability. We also couple the agent transport with the tumor dynamics to simulate chemotherapy with the same vascularized tumor under different vascular pathologies. We show that tumors with an elevated interstitial hydraulic conductivity alone require the strongest dosage to shrink. We further show that tumors with elevated vascular hydraulic conductivity are more hypoxic during therapy and that the response slows down as the tumor shrinks due to the heterogeneity and low concentration of agents in the tumor interior compared with the cases where other pathological effects may combine to flatten the IFP and thus reduce the heterogeneity. We conclude that dual normalizations of the micronevironment - both the vasculature and the interstitium - are needed to maximize the effects of chemotherapy, while normalization of only one of these may be insufficient to overcome the physical resistance and thus leads to sub-optimal outcomes. PMID:24751927

Determination of the Darcy permeability of porous media including sintered metal plugs

NASA Technical Reports Server (NTRS)

Frederking, T. H. K.; Hepler, W. A.; Yuan, S. W. K.; Feng, W. F.

1986-01-01

Sintered-metal porous plugs with a normal size of the order of 1-10 microns are used to evaluate the Darcy permeability of laminar flow at very small velocities in laminar fluids. Porous media experiment results and data adduced from the literature are noted to support the Darcy law analog for normal fluid convection in the laminar regime. Low temperature results suggest the importance of collecting room temperature data prior to runs at liquid He(4) temperatures. The characteristic length diagram gives a useful picture of the tolerance range encountered with a particular class of porous media.

Hypertrophic Pachymeningitis and the Syndrome of Inappropriate Antidiuretic Hormone Secretion: Coincidence or Cause?

PubMed

Harsch, Igor Alexander; Schiffer, Anne; Konturek, Peter C

2017-01-01

To investigate a potential cause of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). A 70-year-old female patient had nausea and collapsed. Although euvolemic, pathological laboratory findings showed hyponatremia and hypoosmolality, and cerebral magnetic resonance imaging showed hypertrophic pachymeningitis. Secondary hypertrophic pachymeningitis was excluded. Other nonneurological reasons for SIADH were also excluded. Moderate fluid restriction restored an almost normal serum osmolality and sodium. This case of SIADH was conservatively treated with moderate fluid restriction that almost restored normal serum osmolality and sodium levels. © 2017 S. Karger AG, Basel.

Hypertrophic Pachymeningitis and the Syndrome of Inappropriate Antidiuretic Hormone Secretion: Coincidence or Cause?

PubMed Central

Harsch, Igor Alexander; Schiffer, Anne; Konturek, Peter C.

2017-01-01

Objective To investigate a potential cause of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Clinical Presentation and Intervention A 70-year-old female patient had nausea and collapsed. Although euvolemic, pathological laboratory findings showed hyponatremia and hypoosmolality, and cerebral magnetic resonance imaging showed hypertrophic pachymeningitis. Secondary hypertrophic pachymeningitis was excluded. Other nonneurological reasons for SIADH were also excluded. Moderate fluid restriction restored an almost normal serum osmolality and sodium. Conclusion This case of SIADH was conservatively treated with moderate fluid restriction that almost restored normal serum osmolality and sodium levels. PMID:28245481

3D seismic imaging of an active, normal fault zone in southern Apennines (Italy): Clues on fluid-driven microearthquake fracturing

NASA Astrophysics Data System (ADS)

Amoroso, O.; Zollo, A.; Virieux, J.

2012-12-01

We have reconstructed a 3D detailed image of the crustal volume embedding the active normal fault system in southern Apennines (Italy). It is obtained by the inversion of P and S first arrival times from microearthquakes recorded in the area. The issues of data quality and the implementation of robust tomographic inversion strategy have been addressed to improve the resolution of the seismic image. The arrival times measurements are enhanced by applying techniques based on polarization filtering and refined re-picking. Data inversion has been performed by using a delay-time 3D tomographic method for the joint determination of source locations and velocity model. The dataset consists of 1311 events with magnitude ranging between [0.1, 3.2], recorded from August 2005 to April 2011 by 42 stations operated by the consortium AMRA scarl and INGV. We used a multi-scale inversion approach, in order to first estimate the large wavelength components of the velocity model and then to progressively introduce smaller scale components. P- and S-wave velocity models show a strong lateral variation along a direction orthogonal to the Apeninic chain, between 0-15 km depth. This variation defines two geological formations which are characterized by relatively low and high P-wave velocities. The sharpest lateral transition occurs in the NE direction: it is well correlated with the location of the NW-SE oriented, primary normal fault associated with the 1980, Ms 6.9 earthquake, which cuts at SW the outcrops of the carbonatic Campanian platform, and separates at NE the older Mesozoic limestone formations from the younger Pliocene-Quaternary basin deposits. The main lithological formations, as identified in the referenced active seismic CROP04 profile, can be recognized in the inferred velocity model. In particular, the structural feature associated with the uplift of the Apulian Platform is well detected by the high P-velocity anomaly ranging between 6.0-6.8 km/s. The thickening of the Lagonegro units located in the axial sector is well reproduced by the low P-wave anomalies ranging between 4.0-4.5 km/s. Their eastward extension is just above the Apulian Platform in the depth range between 4.0 and 8.0 km . The seismicity spatial distribution delineates at SE the border of the Irpinia master fault, while at NE it shows a more diffused pattern due to the presence of a system of highly organized, sub-parallel normal faults as it has been inferred from the fault mechanisms and the coherent orientation of the tensional axes. The Vp/Vs ratio shows a large variability ranging from 1.7-1.8 at shallow depths and increasing up to 2-2.2 between 5 km and 12 km depths, where most of present microseismicity occurs. Such high values are a strong proxy for a fluid-saturated state of rock formations and of their inner pore pressure conditions. The evidence for a predominant microearthquake activity confined within the volume of highest Vp/Vs ratio indicates that pore pressure changes induced by fluid flow/diffusion in a highly fractured medium, may be the primary mechanism controlling and driving the background seismic activity along the Irpinia fault zone.

Male Mating Rate Is Constrained by Seminal Fluid Availability in Bedbugs, Cimex lectularius

PubMed Central

Reinhardt, Klaus; Naylor, Richard; Siva-Jothy, Michael T.

2011-01-01

Sexual selection, differences in reproductive success between individuals, continues beyond acquiring a mating partner and affects ejaculate size and composition (sperm competition). Sperm and seminal fluid have very different roles in sperm competition but both components encompass production costs for the male. Theoretical models predict that males should spend ejaculate components prudently and differently for sperm and seminal fluid but empirical evidence for independent variation of sperm number and seminal fluid volume is scarce. It is also largely unknown how sperm and seminal fluid variation affect future mating rate. In bedbugs we developed a protocol to examine the role of seminal fluids in ejaculate allocation and its effect on future male mating rate. Using age-related changes in sperm and seminal fluid volume we estimated the lowest capacity at which mating activity started. We then showed that sexually active males allocate 12% of their sperm and 19% of their seminal fluid volume per mating and predicted that males would be depleted of seminal fluid but not of sperm. We tested (and confirmed) this prediction empirically. Finally, the slightly faster replenishment of seminal fluid compared to sperm did not outweigh the faster decrease during mating. Our results suggest that male mating rate can be constrained by the availability of seminal fluids. Our protocol might be applicable to a range of other organisms. We discuss the idea that economic considerations in sexual conflict research might benefit from distinguishing between costs and benefits that are ejaculate dose-dependent and those that are frequency-dependent on the mating rate per se. PMID:21779378

Gene mutation analysis in non-small cell lung cancer patients using bronchoalveolar lavage fluid and tumor tissue as diagnostic markers.

PubMed

Li, Jian; Hu, Yi-Ming; Wang, Yi; Tang, Xing-Ping; Shi, Wei-Lin; Du, Yong-Jie

2014-12-09

Non-small cell lung cancer (NSCLC) is one of the main causes of cancer death in the world. Early detection of NSCLC can improve its outcome. The aim of this study was to identify the mutations of the KRAS and p53 genes in bronchoalveoar lavage (BAL) fluid for the early detection of peripheral NSCLC. We examined the DNA obtained from the tumor, nearby normal lung tissue, and matched BAL fluid for mutations in the KRAS and p53 genes; the material was obtained from 48 patients with peripheral NSCLC, and was analyzed by PCR-single strand conformation polymorphism and DNA sequencing. BAL fluids from 26 patients with benign lung disease were used as controls. Positive rates of KRAS and p53 mutations were distributed as follows: in NSCLC tissue, 52% and 58%; in BAL fluid of NSCLC patients, 38% and 44%; in normal lung tissue, 6% and 4%; and in BAL fluid of patients with benign lung disease, 8% and 4%. The combined detection of both KRAS and p53 mutations yielded a sensitivity of 66% for the diagnosis of peripheral NSCLC, which is markedly higher than that of cytology plus histology by first bronchoscopy (38%, p=0.008). In each patient with the 2 gene mutations in BAL fluid, mutation type and location were the same as those of the primary tumor. Our study indicates that the detection of the KRAS and p53 mutations in BAL fluids could be a helpful addition to cytology and histology examination for the diagnosis of peripheral NSCLC.

A randomized, double crossover study to investigate the influence of saline infusion on sleep apnea severity in men.

PubMed

Yadollahi, Azadeh; Gabriel, Joseph M; White, Laura H; Taranto Montemurro, Luigi; Kasai, Takatoshi; Bradley, T Douglas

2014-10-01

Obstructive sleep apnea (OSA) is commoner in patients with fluid-retaining states than in those without fluid retention, in men than in women, and worsens with aging. In men, OSA severity is related to the amount of fluid shifting out of the legs overnight, but a cause-effect relationship is not established. Our objective was to test the hypothesis that mimicking fluid overload during sleep would increase severity of OSA more in older (≥ 40 years) than in younger men (< 40 years). Randomized, single-blind, double crossover study. Research sleep laboratory. Seven older and 10 younger men with non-severe or no sleep apnea, matched for body mass index. During the control arm, normal saline was infused to keep the vein open. During intervention, subjects received an intravenous bolus of normal saline (22 mL/kg body weight) after sleep onset while they were wearing compression stockings to prevent fluid accumulation in the legs. Compared to younger men, infusion of similar amounts of saline in older men caused a greater increase in neck circumference (P < 0.05) and in the AHI (32.2 ± 22.1 vs. 2.2 ± 7.1, P = 0.002). Older men are more susceptible to the adverse effects of intravenous fluid loading on obstructive sleep apnea severity than younger men. This may be due to age-related differences in the amount of fluid accumulating in the neck or upper airway collapsibility in response to intravenous fluid loading. These possibilities remain to be tested in future studies. © 2014 Associated Professional Sleep Societies, LLC.

30 CFR 250.444 - What are the choke manifold requirements?

Code of Federal Regulations, 2010 CFR

2010-07-01

... OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations... abrasiveness of drilling fluids and well fluids that you may encounter. (b) Choke manifold components must have...

Spatial and temporal patterns of airflow across a foredune and beach surface under offshore winds: implications for aeolian sediment transport

NASA Astrophysics Data System (ADS)

Jackson, D.; Delgado-Fernandez, I.; Lynch, K.; Baas, A. C.; Cooper, J. A.; Beyers, M.

2010-12-01

The input of aeolian sediment into foredune systems from beaches represents a key component of sediment budget analysis along many soft sedimentary coastlines. Where there are significant offshore wind components in local wind regimes this is normally excluded from analysis. However, recent work has shown that if the topography of the foredune is favourable then this offshore component is steered or undergoes flow reversal through leeside eddying to give onshore transport events at the back beach under offshore flow conditions. At particular distances from the foredune crest flow reattaches to the surface to continue its incident offshore direction. The location of this reattachment point has important implications for aeolian transport of sand on the back beach and foredune toe locations. This study reports initial results where the positioning of the reattachment point is mobile and is driven by incident wind velocity (at the foredune crest) and the actual undulations of the foredune crest’s topography, dictating heterogeneous flow behaviour at the beach. Using detailed field measurements (25 Hz, three-dimensional sonic anemometry) and computational fluid dynamic modelling, a temporal and spatial pattern of reattachment positions are described. Implications for aeolian transport and dune evolution are also examined.

Human middle-ear model with compound eardrum and airway branching in mastoid air cells

PubMed Central

Keefe, Douglas H.

2015-01-01

An acoustical/mechanical model of normal adult human middle-ear function is described for forward and reverse transmission. The eardrum model included one component bound along the manubrium and another bound by the tympanic cleft. Eardrum components were coupled by a time-delayed impedance. The acoustics of the middle-ear cleft was represented by an acoustical transmission-line model for the tympanic cavity, aditus, antrum, and mastoid air cell system with variable amounts of excess viscothermal loss. Model parameters were fitted to published measurements of energy reflectance (0.25–13 kHz), equivalent input impedance at the eardrum (0.25–11 kHz), temporal-bone pressure in scala vestibuli and scala tympani (0.1–11 kHz), and reverse middle-ear impedance (0.25–8 kHz). Inner-ear fluid motion included cochlear and physiological third-window pathways. The two-component eardrum with time delay helped fit intracochlear pressure responses. A multi-modal representation of the eardrum and high-frequency modeling of the middle-ear cleft helped fit ear-canal responses. Input reactance at the eardrum was small at high frequencies due to multiple modal resonances. The model predicted the middle-ear efficiency between ear canal and cochlea, and the cochlear pressures at threshold. PMID:25994701

Human middle-ear model with compound eardrum and airway branching in mastoid air cells.

PubMed

Keefe, Douglas H

2015-05-01

An acoustical/mechanical model of normal adult human middle-ear function is described for forward and reverse transmission. The eardrum model included one component bound along the manubrium and another bound by the tympanic cleft. Eardrum components were coupled by a time-delayed impedance. The acoustics of the middle-ear cleft was represented by an acoustical transmission-line model for the tympanic cavity, aditus, antrum, and mastoid air cell system with variable amounts of excess viscothermal loss. Model parameters were fitted to published measurements of energy reflectance (0.25-13 kHz), equivalent input impedance at the eardrum (0.25-11 kHz), temporal-bone pressure in scala vestibuli and scala tympani (0.1-11 kHz), and reverse middle-ear impedance (0.25-8 kHz). Inner-ear fluid motion included cochlear and physiological third-window pathways. The two-component eardrum with time delay helped fit intracochlear pressure responses. A multi-modal representation of the eardrum and high-frequency modeling of the middle-ear cleft helped fit ear-canal responses. Input reactance at the eardrum was small at high frequencies due to multiple modal resonances. The model predicted the middle-ear efficiency between ear canal and cochlea, and the cochlear pressures at threshold.

24 CFR 3282.402 - General provisions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... component as the result of normal wear and aging, consumer abuse, or neglect of maintenance. The life of a component warranty may be one of the indicators used to establish normal wear and aging. A failure of any component may not be attributed by the manufacturer to normal wear and aging under this subpart during the...

Magnetic Control of Convection in Electrically Nonconducting Fluids

NASA Technical Reports Server (NTRS)

Huang, Jie; Gray, Donald D.; Edwards, Boyd F.

1999-01-01

Inhomogeneous magnetic fields exert a body force on electrically nonconducting, magnetically permeable fluids. This force can be used to compensate for gravity and to control convection. The effects of uniform and nonuniform magnetic fields on a laterally unbounded fluid layer heated from below or above are studied using a linear stability analysis of the Navier-Stokes equations supplemented by Maxwell's equations and the appropriate magnetic body force. For a uniform oblique field, the analysis shows that longitudinal rolls with axes parallel to the horizontal component of the field are the rolls most unstable to convection. The corresponding critical Rayleigh number and critical wavelength for the onset of such rolls are less than the well-known Rayleigh-Benard values in the absence of magnetic fields. Vertical fields maximize these deviations, which vanish for horizontal fields. Horizontal fields increase the critical Rayleigh number and the critical wavelength for all rolls except longitudinal rolls. For a nonuniform field, our analysis shows that the magnetic effect on convection is represented by a dimensionless vector parameter which measures the relative strength of the induced magnetic buoyancy force due to the applied field gradient. The vertical component of this parameter competes with the gravitational buoyancy effect, and a critical relationship between this component and the Rayleigh number is identified for the onset of convection. Therefore, Rayleigh-Benard convection in such fluids can be enhanced or suppressed by the field. It also shows that magnetothermal convection is possible in both paramagnetic and diamagnetic fluids. Our theoretical predictions for paramagnetic fluids agree with experiments. Magnetically driven convection in diamagnetic fluids should be observable even in pure water using current technology.

Determining effects of turbine blades on fluid motion

DOEpatents

Linn, Rodman Ray [Los Alamos, NM; Koo, Eunmo [Los Alamos, NM

2012-05-01

Disclosed is a technique for simulating wind interaction with wind turbines. A turbine blade is divided into radial sections. The effect that each of these radial sections has on the velocities in Eulerian computational cells they overlap is determined. The effect is determined using Lagrangian techniques such that the calculations need not include wind components in the radial direction. A force on each radial section of turbine blade is determined. This force depends on the axial and azimuthal components of the fluid flow in the computational cell and the geometric properties of the turbine blade. The force on the turbine blade is fed back to effect the fluid flow in the computational cell for the next time step.

Determining effects of turbine blades on fluid motion

DOEpatents

Linn, Rodman Ray [Los Alamos, NM; Koo, Eunmo [Los Alamos, NM

2011-05-31

Disclosed is a technique for simulating wind interaction with wind turbines. A turbine blade is divided into radial sections. The effect that each of these radial sections has on the velocities in Eulerian computational cells they overlap is determined. The effect is determined using Lagrangian techniques such that the calculations need not include wind components in the radial direction. A force on each radial section of turbine blade is determined. This force depends on the axial and azimuthal components of the fluid flow in the computational cell and the geometric properties of the turbine blade. The force on the turbine blade is fed back to effect the fluid flow in the computational cell for the next time step.

Upper-normal waist circumference is a risk marker for metabolic syndrome in normal-weight subjects.

PubMed

Okada, R; Yasuda, Y; Tsushita, K; Wakai, K; Hamajima, N; Matsuo, S

2016-01-01

To elucidate implication of upper-normal waist circumference (WC), we examined whether the normal range of WC still represents a risk of metabolic syndrome (MetS) or non-adipose MetS components among normal-weight subjects. A total of 173,510 persons (100,386 men and 73,124 women) with normal WC (<90/80 cm in men/women) and body mass index (BMI) of 18.5-24.9 were included. Subjects were categorized as having low, moderate, and upper-normal WC for those with WC < 80, 80-84, and 85-89 cm in men and <70, 70-74, and 75-79 cm in women, respectively. The prevalence of all the non-adipose MetS components (e.g. prediabetes and borderline dyslipidemia) was significantly higher in subjects with upper-normal WC on comparison with those with low WC. Overall, the prevalence of MetS (having three or more of four non-adipose MetS components) gradually increased with increasing WC (12%, 21%, and 27% in men and 11%, 14%, and 19% in women for low, moderate, and upper-normal WC, respectively). Moreover, the risk of having a greater number of MetS components increased in subjects with upper-normal WC compared with those with low WC (odds ratios for the number of one, two, three, and four MetS components: 1.29, 1.81, 2.53, and 2.47 in men and 1.16, 1.55, 1.49, and 2.20 in women, respectively). Upper-normal WC represents a risk for acquiring a greater number of MetS components and the early stage of MetS components (prediabetes and borderline dyslipidemia), after adjusting for BMI, in a large general population with normal WC and BMI. Copyright © 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Method and system for gathering a library of response patterns for sensor arrays

DOEpatents

Zaromb, Solomon

1992-01-01

A method of gathering a library of response patterns for one or more sensor arrays used in the detection and identification of chemical components in a fluid includes the steps of feeding samples of fluid with time-spaced separation of known components to the sensor arrays arranged in parallel or series configurations. Modifying elements such as heating filaments of differing materials operated at differing temperatures are included in the configurations to duplicate operational modes designed into the portable detection systems with which the calibrated sensor arrays are to be used. The response patterns from the known components are collected into a library held in the memory of a microprocessor for comparison with the response patterns of unknown components.

Activated complement components and complement activator molecules on the surface of cell‐derived microparticles in patients with rheumatoid arthritis and healthy individuals

PubMed Central

Biró, Éva; Nieuwland, Rienk; Tak, Paul P; Pronk, Loes M; Schaap, Marianne C L; Sturk, Augueste; Hack, C Erik

2007-01-01

Objectives In vitro, microparticles can activate complement via the classical pathway. If demonstrable ex vivo, this mechanism may contribute to the pathogenesis of rheumatoid arthritis (RA). We therefore investigated the presence of activated complement components and complement activator molecules on the surface of cell‐derived microparticles of RA patients and healthy individuals. Methods Microparticles from synovial fluid (n = 8) and plasma (n = 9) of 10 RA patients and plasma of sex‐ and age‐matched healthy individuals (n = 10) were analysed by flow cytometry for bound complement components (C1q, C4, C3) and complement activator molecules (C‐reactive protein (CRP), serum amyloid P component (SAP), immunoglobulin (Ig) M, IgG). Results Microparticles with bound C1q, C4, and/or C3 were abundant in RA synovial fluid, while in RA and control plasma much lower levels were present. Microparticles with bound C1q correlated with those with bound C3 in synovial fluid (r = 0.961, p = 0.0001), and with those with bound C4 in plasma (RA: r = 0.908, p = 0.0007; control: r = 0.632, p = 0.0498), indicating classical pathway activation. In synovial fluid, microparticles with IgM and IgG correlated with those with C1q (r = 0.728, p = 0.0408; r = 0.952, p = 0.0003, respectively), and in plasma, microparticles with CRP correlated with those with C1q (RA: r = 0.903, p = 0.0021; control: r = 0.683, p = 0.0296), implicating IgG and IgM in the classical pathway activation in RA synovial fluid, and CRP in the low level classical pathway activation in plasma. Conclusions This study demonstrates the presence of bound complement components and activator molecules on microparticles ex vivo, and supports their role in low grade complement activation in plasma and increased complement activation in RA synovial fluid. PMID:17261534

High-resolution simulations of multi-phase flow in magmatic-hydrothermal systems with realistic fluid properties

NASA Astrophysics Data System (ADS)

Geiger, S.; Driesner, T.; Matthai, S.; Heinrich, C.

2002-12-01

Realistic modelling of multi-phase fluid flow, energy and component transport in magmatic-hydrothermal systems is very challenging because hydrological properties of fluids and rocks vary over many orders of magnitude and the geometric complexities of such systems. Furthermore, density dependent component transport and transient permeability variations due to P-T changes and fluid-rock interactions introduce additional difficulties. As a result, the governing equations for the hydrodynamics, energy and component transport, and thermodynamics in magmatic hydrothermal systems are highly non-linear and strongly coupled. Essential requirements of a numerical formulation for such a system are: (1) a treatment of the hydrodynamics that can accurately resolve complex geological structures and represent the highly variable fluid velocities herein, (2) a realistic thermodynamic representation of the fluid properties including the wide P-T-X range of liquid+vapour coexistence for the highly saline fluids, and (3) an accurate handling of the highly contrasting transport properties of the two fluids. We are combining higher order finite-element (FE) methods with total variation diminishing finite volume (TVDFV) methods to model the hydrodynamics and energy and component transport of magmatic hydrothermal systems. Combined FE and TVDFV methods are mass and shock preserving, yield great geometric flexibility in 2D and 3D [2]. Furthermore, efficient matrix solvers can be employed to model fluid flow in geologically realistic structures [5]. The governing equations are linearized by operator-splitting and solved sequentially using a Picard iteration scheme. We chose the system water-NaCl as a realistic proxy for natural fluids occurring in magmatic-hydrothermal systems. An in-depth evaluation of the available experimental and theoretical data led to a consistent and accurate set of formulations for the PVTXH relations that are valid from 0 to 800 C, 0 to 500 MPa, and 0 to 1 XNaCl. Dynamic viscosities are currently approximated by the approach of Palliser and McKibbin [4]. The numerical solutions of the governing equations and the equation of state are embedded in our object-oriented C++ code CSP3D4.0 [6]. Comparisons of the numerical solutions carried out with CSP for solute transport with analytical solutions and classical test cases for density dependent flow (i.e., Elder problem [1]) show very good agreement. The numerical solutions carried out with CSP and the established United States Geological Survey code HYDROTHERM [3] for multi-phase flow and energy transport also yield a very good agreement. Fluid inclusion data can be used to constrain the PTX properties of the hydrothermal fluids in numerical solutions. [1] Journal of Fluid Mechanics 27, 609-623 [2] ANU Mathematical Research Report, MRR01-023 [3] USGS Water Investigations Report 94-4045 [4] Transport in Porous Media 33, 155-171 [5] AAPG Bulletin 80, 1763-1779 [6] CSP User's Guide, Dept. of Earth Sciences ETH Zurich

2D Simulations of Earthquake Cycles at a Subduction Zone Based on a Rate and State Friction Law -Effects of Pore Fluid Pressure Changes-

NASA Astrophysics Data System (ADS)

Mitsui, Y.; Hirahara, K.

2006-12-01

There have been a lot of studies that simulate large earthquakes occurring quasi-periodically at a subduction zone, based on the laboratory-derived rate-and-state friction law [eg. Kato and Hirasawa (1997), Hirose and Hirahara (2002)]. All of them assume that pore fluid pressure in the fault zone is constant. However, in the fault zone, pore fluid pressure changes suddenly, due to coseismic pore dilatation [Marone (1990)] and thermal pressurization [Mase and Smith (1987)]. If pore fluid pressure drops and effective normal stress rises, fault slip is decelerated. Inversely, if pore fluid pressure rises and effective normal stress drops, fault slip is accelerated. The effect of pore fluid may cause slow slip events and low-frequency tremor [Kodaira et al. (2004), Shelly et al. (2006)]. For a simple spring model, how pore dilatation affects slip instability was investigated [Segall and Rice (1995), Sleep (1995)]. When the rate of the slip becomes high, pore dilatation occurs and pore pressure drops, and the rate of the slip is restrained. Then the inflow of pore fluid recovers the pore pressure. We execute 2D earthquake cycle simulations at a subduction zone, taking into account such changes of pore fluid pressure following Segall and Rice (1995), in addition to the numerical scheme in Kato and Hirasawa (1997). We do not adopt hydrostatic pore pressure but excess pore pressure for initial condition, because upflow of dehydrated water seems to exist at a subduction zone. In our model, pore fluid is confined to the fault damage zone and flows along the plate interface. The smaller the flow rate is, the later pore pressure recovers. Since effective normal stress keeps larger, the fault slip is decelerated and stress drop becomes smaller. Therefore the smaller flow rate along the fault zone leads to the shorter earthquake recurrence time. Thus, not only the frictional parameters and the subduction rate but also the fault zone permeability affects the recurrence time of earthquake cycle. Further, the existence of heterogeneity in the permeability along the plate interface can bring about other slip behaviors, such as slow slip events. Our simulations indicate that, in addition to the frictional parameters, the permeability within the fault damage zone is one of essential parameters, which controls the whole earthquake cycle.

The van Hove distribution function for Brownian hard spheres: Dynamical test particle theory and computer simulations for bulk dynamics

NASA Astrophysics Data System (ADS)

Hopkins, Paul; Fortini, Andrea; Archer, Andrew J.; Schmidt, Matthias

2010-12-01

We describe a test particle approach based on dynamical density functional theory (DDFT) for studying the correlated time evolution of the particles that constitute a fluid. Our theory provides a means of calculating the van Hove distribution function by treating its self and distinct parts as the two components of a binary fluid mixture, with the "self " component having only one particle, the "distinct" component consisting of all the other particles, and using DDFT to calculate the time evolution of the density profiles for the two components. We apply this approach to a bulk fluid of Brownian hard spheres and compare to results for the van Hove function and the intermediate scattering function from Brownian dynamics computer simulations. We find good agreement at low and intermediate densities using the very simple Ramakrishnan-Yussouff [Phys. Rev. B 19, 2775 (1979)] approximation for the excess free energy functional. Since the DDFT is based on the equilibrium Helmholtz free energy functional, we can probe a free energy landscape that underlies the dynamics. Within the mean-field approximation we find that as the particle density increases, this landscape develops a minimum, while an exact treatment of a model confined situation shows that for an ergodic fluid this landscape should be monotonic. We discuss possible implications for slow, glassy, and arrested dynamics at high densities.

Uniform phases in fluids of hard isosceles triangles: One-component fluid and binary mixtures

NASA Astrophysics Data System (ADS)

Martínez-Ratón, Yuri; Díaz-De Armas, Ariel; Velasco, Enrique

2018-05-01

We formulate the scaled particle theory for a general mixture of hard isosceles triangles and calculate different phase diagrams for the one-component fluid and for certain binary mixtures. The fluid of hard triangles exhibits a complex phase behavior: (i) the presence of a triatic phase with sixfold symmetry, (ii) the isotropic-uniaxial nematic transition is of first order for certain ranges of aspect ratios, and (iii) the one-component system exhibits nematic-nematic transitions ending in critical points. We found the triatic phase to be stable not only for equilateral triangles but also for triangles of similar aspect ratios. We focus the study of binary mixtures on the case of symmetric mixtures: equal particle areas with aspect ratios (κi) symmetric with respect to the equilateral one, κ1κ2=3 . For these mixtures we found, aside from first-order isotropic-nematic and nematic-nematic transitions (the latter ending in a critical point): (i) a region of triatic phase stability even for mixtures made of particles that do not form this phase at the one-component limit, and (ii) the presence of a Landau point at which two triatic-nematic first-order transitions and a nematic-nematic demixing transition coalesce. This phase behavior is analogous to that of a symmetric three-dimensional mixture of rods and plates.

CT and MRI assessment of symptomatic organized pancreatic fluid collections and pancreatic duct disruption: an interreader variability study using the revised Atlanta classification 2012.

PubMed

Kamal, Ayesha; Singh, Vikesh K; Akshintala, Venkata S; Kawamoto, Satomi; Tsai, Salina; Haider, Maera; Fishman, Elliot K; Kamel, Ihab R; Zaheer, Atif

2015-08-01

Compare CT and MRI for fluid/debris component estimate and pancreatic duct (PD) communication with organized pancreatic fluid collections in acute pancreatitis. Evaluate fat density globules on CT as marker for debris. 29 Patients with 46 collections with CECT and MRI performed ≥4 weeks of symptom onset assessed for necrotizing pancreatitis, estimated percentage of fluid volume and PD involvement by two radiologists on separate occasions. T2WI used as standard for estimated percentage of fluid volume. Presence of fat globules and fluid attenuation on CT was recorded. Spearman rank correlation and kappa statistics were used to assess the correlation between imaging techniques and interreader agreement, respectively. Necrotizing pancreatitis seen on CT in 27 (93%, κ 0.119) vs. 20 (69%, κ 0.748) patients on MRI. CT identified 42 WON and 4 pseudocysts vs. 34 WON, and 12 pseudocysts on MRI. Higher interreader agreement for percentage fluid volume on MRI (κ = 0.55) vs. CT (κ = 0.196). Accuracy of CT in evaluation of percentage fluid volume was 65% using T2WI MRI used as standard. Fat globules identified on CT in 13(65%) out of 20 collections containing <75% fluid vs. 4(15%) out of 26 collections containing >75% fluid (p = 0.0001). PD involvement confidently excluded on CT in 68% collections vs. 93% on MRI. MRI demonstrates higher reproducibility for fluid to debris component estimation. Fat globules on CT were frequently seen in organized pancreatic fluid collections with large amount of debris. PD disruption more confidently excluded on MRI. This information may be helpful for pre-procedure planning.

14 CFR 25.1183 - Flammable fluid-carrying components.

Code of Federal Regulations, 2012 CFR

2012-01-01

... safeguard against the ignition of leaking flammable fluid. An integral oil sump of less than 25-quart..., essential services or equipment. [Doc. No. 5066, 29 FR 18291, Dec. 24, 1964, as amended by Amdt. 25-11, 32...