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Sample records for nos distrito federal

  1. Demographic, epidemiological and nutritional profile of elders using home enteral nutritional therapy in Distrito Federal, Brazil.

    PubMed

    Salomon Zaban, Ana Lúcia Ribeiro; Garbi Novaes, Maria Rita Carvalho

    2009-09-01

    According to statistical projections of the World Health Organization, during the period between 1950 and 2025, the group of elderly in Brazil will have increased 15 times. Chronic-degenerative diseases are the illnesses that most affect the elderly population, directly related to the growing demand for Enteral Nutrition Therapy. The objective of this study was to analyze the demographic, epidemiological and nutritional profile of elderly patients assisted at the public hospitals in the Home Enteral Nutrition Therapy Program, of the State Health Department of Distrito Federal. This is a retroprospective, cross-sectional and analytical study, based on primary data, which enrolled 141 elderly patients who were prescribed home enteral nutrition. The collected variables corresponded to age, gender, clinical diagnosis, enteral route and nutritional status at the beginning of Home Enteral Nutrition Therapy. The association between variables was analyzed through the t-Student and chi-square tests, with a significance level of 0.05 and a Confidence Interval (CI) of 95%. There was a higher number of female patients (53.9%) when compared to male (46.1%), average age 75.82 years old for both groups. The most prevalent diseases were cerebro-vascular accident sequels and cancer (42.6% and 22.7% respectively). It was observed a prevalence of malnutrition equal to 69.7%, independent of age and gender. The most used enteral route was the nasal. Though Brazilian policies concerning assistance to the elderly have advanced during the last few years, the need for public policies for nutritional recovery of such patients persists, to promote a better quality of life for them.

  2. DEZ ANOS DE EXPERIÊNCIA DO COMITÊ DE ÉTICA EM PESQUISA DA SECRETARIA DE SAÚDE DO DISTRITO FEDERAL, BRASIL

    PubMed Central

    Novaes, Maria Rita C. G.; Guilhem, Dirce; Lolas, Fernando

    2009-01-01

    O objetivo deste artigo é relatar a experiência do Comitê de Ética em Pesquisa da Secretaria de Estado de Saúde do Distrito Federal (CEP/SES/DF) Brasil, durante o período de 10 anos a partir de sua fundação. Trata-se de uma avaliação descritiva e documental, na modalidade estudo de caso, utilizando-se a totalidade de projetos protocolados no CEP/SES/DF (N° 052/08) nesse período. As pendências mais freqüentes dos projetos foram: termo de consentimento livre e esclarecido (30%), folha de rosto (25%), metodologia (20%), curriculum vitae (12%), planilha de orçamento (9%), outros (4%). O relato das atividades do CEP/SES/DF no período de 10 anos revelou, através de sua produtividade, a legitimidade do processo de análise ética dos protocolos visando à proteção dos participantes da pesquisa. PMID:19888441

  3. [Metabolic parameters and risk factors associated with abdominal obesity among female adolescents in public schools in the Distrito Federal (Brazil)].

    PubMed

    Pinto, Karina Alves de Castro; Priore, Silvia Eloiza; de Carvalho, Kênia Mara Baiocchi

    2011-03-01

    This study aimed to estimate the prevalence of abdominal obesity and investigate their association with parameters markers of metabolic syndrome (MS) and its risk factors in female adolescents. It is a cross-sectional study with 150 adolescents from 10 public schools in the Federal District, Brazil. The presence of abdominal obesity was considered by measuring waist circumference above the 80th percentile, according to Taylor et al. (2000). The associated factors included sociodemographic characteristics, health status of adolescents and their parents, physical activity, eating habits, blood pressure and biochemical profile. The abdominal obesity prevalence ratio (PR) was estimated by Poisson regression model, with 95% CI. Among the adolescents studied (age= 15.6 +/- 0.8 years; BMI = 21.0 +/- 3.0 kg/m2), prevalence of abdominal obesity was 20%, and this condition was not associated with sociodemographic variables, physical activity and diet. However, abdominal obesity was significantly associated with intake of less than 4 meals a day (PR = 2.27; IC95% 1.27-4.10), previous obesity (PR = 2.36; IC95% 1.31-4.01), history of parental chronic disease (PR = 3.55; IC 95% 1.63-7.75), fasting insulin = 15 uUi/mL (PR = 3.05; IC 95% 1.36-6.82) e HDL-c > 40 mg/dL (PR = 0.39; IC95% 0.23-0.67). In this population, modifiable factors, family history and determinants of MS, such as insulin and HDL-c were associated with abdominal obesity, which points to the need for effective health promotion among adolescents.

  4. ANÁLISE DA INSERÇÃO DOS TEMAS DE HUMANIDADES E ÉTICA, COM METODOLOGIA DE APRENDIZAGEM BASEADA EM PROBLEMAS, EM CURRICULO MÉDICO INTEGRADO EM ESCOLA PÚBLICA NO DISTRITO FEDERAL, BRASIL

    PubMed Central

    Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Lolas, Fernando; Silveira, Carla; Guiotti, Murilo

    2009-01-01

    Objetivo Realizar uma análise da inserção da ética e humanidades no currículo do Curso de Medicina da Escola Superior em Ciências da Saúde - ESCS, escola pública do Distrito Federal, Brasil, de forma a contribuir com o processo de gestão curricular. Metodologia O Estudo é de coorte e documental. Foram pesquisados 37 termos relacionados à ética e 36 referentes à humanização nos objetivos educacionais e conteúdo dos módulos temáticos, habilidades e atitudes e interação ensino-serviço-comunidade, de 1a a 4a série e no programa do internato no currículo (ano 2006) e no projeto pedagógico do Curso de Medicina (2001). Resultados Maior inserção da humanização, ética e bioética na 1a e 2a série, quando comparado à inserção na 3a e 4a série e no internato, (IC95%-α=0,034, pvalue=0,007). Unidade de habilidades e atitudes: freqüência das 3 temáticas no currículo da 1a a 4a séries (IC95%-α=0,026, pvalue=0,013). Quando comparada a inserção entre o internato e as quatro primeiras séries, observa-se que nestas a inserção da temática humanização é superior (IC95%-α=0,042, pvalue=0,029). Conclusão O currículo desenvolvido no ano de 2006 na ESCS apresentou correlação com o projeto pedagógico do curso e contemplou a temática de forma abrangente, em todas as séries e internato. PMID:20396594

  5. 48 CFR Appendix to Part 6101 - Form Nos. 1-5

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Form Nos. 1-5 Appendix to Part 6101 Federal Acquisition Regulations System CIVILIAN BOARD OF CONTRACT APPEALS, GENERAL SERVICES ADMINISTRATION CONTRACT DISPUTE CASES Pt. 6101, App. Appendix to Part 6101—Form Nos. 1-5 Form 1, GSA Form...

  6. The NOS Challenge

    ERIC Educational Resources Information Center

    Quigley, Cassie; Buck, Gayle; Akerson, Valarie

    2011-01-01

    "The picture of a scientist is me!" exclaims first grader Kendra during a nature of science (NOS) lesson. She drew a picture of a scientist and explained that she was going to be a scientist when she grew up because she "loved to observe like a scientist." Kendra's experience was a part of a 30-day unit designed specifically for first graders.…

  7. 78 FR 39018 - Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating Unit Nos. 2 and 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating Unit Nos. 2 and 3 AGENCY: Nuclear Regulatory Commission. ACTION: Supplement to Final Supplement 38 to the Generic...

  8. Federated Giovanni

    NASA Technical Reports Server (NTRS)

    Lynnes, C.

    2014-01-01

    Federated Giovanni is a NASA-funded ACCESS project to extend the scope of the GES DISC Giovanni online analysis tool to 4 other Distributed Active Archive Centers within EOSDIS: OBPG, LP-DAAC, MODAPS and PO.DAAC. As such, it represents a significant instance of sharing technology across the DAACs. We also touch on several sub-areas that are also sharable, such as Giovanni URLs, workflows and OGC-accessible services.

  9. 75 FR 3946 - License Nos. DPR-42 and DPR-60; Northern States Power Company; Prairie Island Nuclear Generating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... Nuclear Reactor Regulation. BILLING CODE 7590-01-P ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION License Nos. DPR-42 and DPR-60; Northern States Power Company; Prairie Island Nuclear...

  10. NOS1 — EDRN Public Portal

    Cancer.gov

    NOS1, or nitric oxide synthase 1 (neuronal), along with inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3), catalyze the generation of nitric oxide and L-citrulline from L-arginine and molecular oxygen. Nitric oxide is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter. NOS1 also displays antimicrobial and antitumoral activities.

  11. Understanding the Federal Courts.

    ERIC Educational Resources Information Center

    Administrative Office of the United States Courts, Washington, DC.

    This booklet discusses the workings of the federal courts and supports six law-related lesson plans. It is divided into the following sections: "The Constitution and the Federal Judiciary"; "The Federal Courts in American Government" ("The Federal Courts and Congress"; "The Federal Courts and the Executive…

  12. Expression profiles of NOS isoforms in gingiva of nNOS knockout mice.

    PubMed

    Ishioka, M; Ishizuka, Y; Shintani, S; Yanagisawa, T; Inoue, T; Sasaki, J; Watanabe, H

    2014-04-01

    Nitric oxide is a gaseous molecule associated with many distinct physiological functions, and is derived from L-arginine catalyzed by nitric oxide synthase (NOS). Nitric oxide synthase has 3 isoforms: nNOS, iNOS and eNOS. Although these NOS isoforms are believed to play an important role in gingival tissue, little information is available on their morphological dynamics. The aim of this study was to investigate the profiles of NOS isoforms in deficiency of nNOS in gingiva of mice. Twelve male (6 normal (C57BL/6) and 6 nNOS knockout) mice were used. All mice were 5-week-old, weighing approximately 20-25 g each. After sacrifice, the jaws of the mice were removed by mechanical means and specimens analyzed by histology, in situ hybridization and immunohistochemistry. Immunohistochemical observation revealed positive staining for iNOS and eNOS, especially in lamina propria. Similar results in the mRNA expression levels were shown by in situ hybridization analysis. It may suggest that iNOS and eNOS compensated nNOS deficiency in the gingiva of nNOS knockout mice.

  13. Federal Student Loan Programs

    ERIC Educational Resources Information Center

    Federal Student Aid, US Department of Education, 2014

    2014-01-01

    For those needing a loan to attend college, think federal aid first. Federal student loans usually offer borrowers lower interest rates and have more flexible repayment terms and options than private student loans. This brief report answers the following questions about federal aid: (1) What is a federal student loan?; (2) What is a private…

  14. Vascular and Perivascular NO Release and Transport: Biochemical Pathways of NOS1 and NOS3

    PubMed Central

    Chen, Kejing; Popel, Aleksander S.

    2007-01-01

    Nitric oxide (NO) derived from nitric oxide synthase (NOS) is an important paracrine effector that maintains vascular tone. The release of NO mediated by NOS isozymes under various O2 conditions critically determines the NO bioavailability in tissues. Because of experimental difficulties, there has been no direct information on how enzymatic NO production and distribution change around arterioles under various oxygen conditions. In this study, we used computational models based on the analysis of biochemical pathways of enzymatic NO synthesis and the availability of NOS isozymes to quantify the NO production by neuronal NOS (NOS1) and endothelial NOS (NOS3). We compared the catalytic activities of NOS1 and NOS3 and their sensitivities to the concentration of substrate O2. Based on the NO release rates predicted from kinetic models, the geometric distribution of NO sources and mass balance analysis, we predicted the NO concentration profiles around an arteriole under various O2 conditions. The results indicated that NOS1-catalyzed NO production was significantly more sensitive to ambient O2 concentration than that catalyzed by NOS3. Also, the high sensitivity of NOS1 catalytic activity to O2 was associated with significantly reduced NO production and therefore NO concentrations, upon hypoxia. Moreover, the major source determining the distribution of NO was NOS1, which was abundantly expressed in the nerve fibers and mast cells close to arterioles, rather than NOS3, which was expressed in the endothelium. Finally, the perivascular NO concentration predicted by the models under conditions of normoxia was paradoxically at least an order of magnitude lower than a number of experimental measurements, suggesting a higher abundance of NOS1 or NOS3 and/or the existence of other enzymatic or non-enzymatic sources of NO in the microvasculature. PMID:17320763

  15. 76 FR 5787 - Federal Perkins Loan, Federal Work-Study, and Federal Supplemental Educational Opportunity Grant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... Federal Perkins Loan, Federal Work-Study, and Federal Supplemental Educational Opportunity Grant Programs... Perkins Loan, Federal Work-Study (FWS), and Federal Supplemental Educational Opportunity Grant (FSEOG... Federal Perkins Loan Program, Federal Work-Study Program, and Federal Supplemental Educational...

  16. TAP Service Federation Factory

    NASA Astrophysics Data System (ADS)

    Hume, A. C.; Krause, A.; Holliman, M.; Mann, R. G.; Noddle, K.; Voutsinas, S.

    2012-09-01

    This paper describes a prototype federation service for multiple TAP endpoints. Users can create a new TAP resource that allows them to query the federation as if all tables were in a single database.

  17. 77 FR 4547 - Federal Perkins Loan, Federal Work-Study, and Federal Supplemental Educational Opportunity Grant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-30

    ... Federal Perkins Loan, Federal Work-Study, and Federal Supplemental Educational Opportunity Grant Programs... requests and documents from postsecondary institutions for the Federal Perkins Loan, Federal Work-Study.... (2) General Provisions for the Federal Perkins Loan Program, Federal Work-Study Program, and...

  18. 78 FR 14776 - Federal Perkins Loan, Federal Work-Study, and Federal Supplemental Educational Opportunity Grant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ... Federal Perkins Loan, Federal Work-Study, and Federal Supplemental Educational Opportunity Grant Programs... requests and documents from postsecondary institutions for the Federal Perkins Loan, Federal Work-Study..., Federal Work-Study Program, and Federal Supplemental Educational Opportunity Grant Program, 34 CFR...

  19. 75 FR 12217 - Federal Perkins Loan, Federal Work-Study, and Federal Supplemental Educational Opportunity Grant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... Federal Perkins Loan, Federal Work-Study, and Federal Supplemental Educational Opportunity Grant programs... Perkins Loan, Federal Work-Study (FWS), and Federal Supplemental Educational Opportunity Grant (FSEOG.... (2) General Provisions for the Federal Perkins Loan Program, Federal Work-Study Program, and...

  20. Federal Employees' Compensation Act.

    PubMed

    Ladou, Joseph

    2009-01-01

    The Federal Employees' Compensation Act (FECA) program provides wage loss compensation and payments for medical treatment to federal civilian employees. Administered by the Department of Labor (DOL), FECA covers over 2.7 million federal employees in more than 70 different agencies. FECA costs rose from $1.4 billion in 1990 to $2.6 in 2006, while the federal workforce remained essentially unchanged. While federal civilian employees represent only 2.1% of all workers eligible for workers' compensation benefits, federal programs account for 6% of the benefits paid. Disability benefits under FECA are far greater than those in the state workers' compensation programs. The benefit payments often exceed the former salary of the injured employee. The last congressional hearings on the FECA program were held over thirty years ago. It is unlikely that Congressional review will occur any time soon, as the entrenched bureaucracy that benefits from the FECA program defines and protects its future.

  1. 77 FR 64827 - Investigation Nos. 701-TA-402 and 731-TA-892 (Second Review); Honey From Argentina; Termination...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Investigation Nos. 701-TA-402 and 731-TA-892 (Second Review); Honey From Argentina; Termination of... countervailing duty order and antidumping duty order on imports of honey from Argentina would be likely to...

  2. Application Kit for Federal Assistance

    EPA Pesticide Factsheets

    The Federal Grant & Cooperative Agreement Act of 1977 requires Federal agencies to use a contract to acquire property or services that directly benefit the Federal government.This letter to the applicant explains the Application Kit for Federal Assistance.

  3. Federal Agency and Federal Library Reports.

    ERIC Educational Resources Information Center

    Williams, Jane; Wooding, Janet E.; Lisowski, Lori A.; Borys, Cynthia; Chute, Adrienne; Fischer, Audrey; Cole, John Y.; Tarr, Susan M.; Norris, Brian; Mehnert, Robert; Brandhorst, Ted; Sherman, Andrew M.

    1998-01-01

    Contains reports from National Commission on Libraries and Information Science, National Technical Information Service, National Archives, U.S. Information Agency, National Center for Education Statistics, Library of Congress, Center for the Book, Federal Library and Information Center Committee, National Agricultural Library, National Library of…

  4. Federal Agency and Federal Library Reports.

    ERIC Educational Resources Information Center

    Wooding, Janet E; Lisowski, Lori A.; Gilliam, Bo; Chute, Adrienne; Fischer, Audrey; Cole, John Y.; Tarr, Susan M.; Norris, Brian; Mehnert, Robert; Brandhorst, Ted; Sherman, Andrew M.; Willard, Robert S.

    1999-01-01

    Presents reports from: National Technical Information Service; National Archives and Records Administration; United States Information Agency; National Center for Educational Statistics Library Statistics Cooperative Program; Library of Congress; Center for the Book; Federal Library and Information Center Committee; National Agricultural Library;…

  5. Multifaceted NOS Instruction: Contextualizing Nature of Science with Documentary Films

    ERIC Educational Resources Information Center

    Bloom, Mark; Binns, Ian C.; Koehler, Catherine

    2015-01-01

    This research focuses on inservice science teachers' conceptions of nature of science (NOS) before and after a two-week intensive summer professional development (PD). The PD combined traditional explicit NOS instruction, numerous interactive interventions that highlighted NOS aspects, along with documentary films that portrayed NOS in context of…

  6. mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models

    PubMed Central

    Colton, Carol A.; Wilson, Joan G.; Everhart, Angela; Wilcock, Donna M.; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P.

    2014-01-01

    Abstract Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease–like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI+/+/mNos2−/− (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI+/−/HuNOS2tg+/+/mNos2−/−) mimicked the pathologic phenotypes found in the CVN-AD strain. PMID:25003233

  7. mNos2 deletion and human NOS2 replacement in Alzheimer disease models.

    PubMed

    Colton, Carol A; Wilson, Joan G; Everhart, Angela; Wilcock, Donna M; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P

    2014-08-01

    Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease-like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI(+)/(+)mNos2(-/-) (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI(+)/(-)/HuNOS2(tg+)/(+)/mNos2(-/-)) mimicked the pathologic phenotypes found in the CVN-AD strain.

  8. Federal Legislative Proposals, 1969.

    ERIC Educational Resources Information Center

    Education Commission of the States, Denver, CO.

    The commission outlined a legislative program at the Federal level. Federal aid should come under the direct control of the executive branch to consolidate and simplify all education aid programs. This reorganization should include continuous and effective presentation of the State point of view to the responsible authorities. A new three-tiered…

  9. Federalism, Agenda Setting, and the Dynamics of Federal Education Policy.

    ERIC Educational Resources Information Center

    Manna, Paul

    This paper is part of a larger project on agenda setting in the U.S. federal system and the development of the federal education agenda since 1965. Two questions motivate the paper, one theoretical and the other empirical: (1) how does federalism affect the federal agenda?; and (2) what explains the development of federal involvement in K-12…

  10. Federal Sector Negotiability

    DTIC Science & Technology

    1989-01-01

    LogisticsCouncil v. Federal Labor Relations Authority, 810 F.2d 234, 241- 242 (D.C. Cir. 1987); Circuit Judge D.H. Ginsburg writing for the court in United...concurring and dissenting in Defense Logistics Council v. Federal Labor Relations Authority, 810 F.2d 234, 241- 242 (D.C. Cir. 1987); Judge D.H. Ginsburg...cert. dismissed 106 S.Ct. 1678 (1986) (per curium ); American Federation of State. County and Municipal Employees. Local 3097 and Department of Justice

  11. Federal participation in LEED

    SciTech Connect

    Payne, Christopher; Dyer, Beverly

    2004-11-10

    The federal government has been an active participant in the development and use of USGBC's Leadership in Energy & Environmental Design Green Building Rating System (LEED). This paper presents a review of this participation and some expectations for ongoing partnership.

  12. Federal Internship Improvement Act

    THOMAS, 112th Congress

    Rep. Connolly, Gerald E. [D-VA-11

    2011-03-03

    03/18/2011 Referred to the Subcommittee on Federal Workforce, U.S. Postal Service, and Labor Policy. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  13. 78 FR 27968 - Federal Management Regulation; Redesignations of Federal Buildings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... redesignated buildings are as follows: Former Name New Name Ariel Rios Federal Building William Jefferson... Midland, TX 79701 Federal Office Building 8 Thomas P. O'Neill, Jr., Federal Building 200 C Street, SW....

  14. Federal Guidance for Radiation Protection

    EPA Pesticide Factsheets

    EPA produces federal guidance technical reports, which standardize dose and risk assessment and issues radiation protection guidance to federal agencies. This page provides links to federal guidance policy recommendations and technical reports.

  15. Rural Education: The Federal Response.

    ERIC Educational Resources Information Center

    Hearn, Norman E.

    1981-01-01

    Reviews federal efforts to develop a rural education federal agenda, five basic problems of rural areas which lend themselves to federal solutions, Department of Education proposals for fiscal year 1982, significant federal responses/already in progress, and strengths and advantages of rural schools. (AN)

  16. Federal Forecasters Directory, 1995.

    ERIC Educational Resources Information Center

    National Center for Education Statistics (ED), Washington, DC.

    This directory lists employees of the federal government who are involved in forecasting for policy formation and trend prediction purposes. Job title, agency, business address, phone or e-mail number, and specialty areas are listed for each employee. Employees are listed for the following agencies: (1) Bureau of the Census; (2) Bureau of Economic…

  17. Federal-State Relationships.

    ERIC Educational Resources Information Center

    Bystrom, John

    The Federal Communications Commission in 1938 set aside AM radio assignments for future educational stations. In the 1960's it made additional assignments for education: long-range FM radio, multiplex sub-carrier channels; and UHF, VHF, and Instructional Television Fixed Service channels for statewide ETV broadcast service. Such networks aid the…

  18. Federal Regulation of Education.

    ERIC Educational Resources Information Center

    Shapiro, Martin

    Fresh light might be shed on problems of federal education policy by treating them not only as problems of intergovernmental relations but of government regulation of enterprise, given that they involve the attempts of a central government to influence the conduct of enterprises that it does not own nor directly operate. Using well-established…

  19. Defensive Federal Litigation

    DTIC Science & Technology

    2007-11-02

    of Substantive Rights .... 4-15 ( b ) Back Pay Claim s ................................................................ 4- 23 (c) O ther Issues...3): V enue ......................................................................... 2-26 d . Rule 12( b )(7): Indispensable Parties...Federal Tort Claim s A ct ....................................................... 4-7 ( d ) O ther Statutes

  20. Needle Federated Search Engine

    SciTech Connect

    2009-12-01

    The Idaho National Laboratory (INL) has combined a number of technologies, tools, and resources to accomplish a new means of federating search results. The resulting product is a search engine called Needle, an open-source-based tool that the INL uses internally for researching across a wide variety of information repositories. Needle has a flexible search interface that allows end users to point at any available data source. A user can select multiple sources such as commercial databases (Web of Science, Engineering Index), external resources (WorldCat, Google Scholar), and internal corporate resources (email, document management system, library collections) in a single interface with one search query. In the future, INL hopes to offer this open-source engine to the public. This session will outline the development processes for making Needle™s search interface and simplifying the federation of internal and external data sources.

  1. Federal Interagency Geothermal Activities

    SciTech Connect

    Anderson, Arlene; Prencipe, Loretta; Todaro, Richard M.; Cuyler, David; Eide, Elizabeth

    2011-06-01

    This collaborative document describes the roles and responsibilities of key Federal agencies in the development of geothermal technologies including the U.S. Department of Energy (DOE); the U.S. Department of Agriculture (USDA), including the U.S. Forest Service; the U.S. Department of Interior (DOI), including the United States Geological Survey (USGS) and Bureau of Land Management (BLM); the Environmental Protection Agency (EPA); and the Department of Defense (DOD).

  2. Indochina: The Federation Factor.

    DTIC Science & Technology

    1982-12-01

    alliances unite territorial units to form "communities" or "blocs", or confederations. Other usual features of modern alliances are: 1. They are...Revolution in Modern Vietnam. Boston: Houghton Mifflin Co., 1976. Woodside, Alexander B., Vietnam and the Chinese Model: A Comparative Study of Nguyen and...of an Indo- chinese Federation. While a trend toward greater regional associations has been observed - both historically and during the recent past

  3. Federating Metadata Catalogs

    NASA Astrophysics Data System (ADS)

    Baru, C.; Lin, K.

    2009-04-01

    The Geosciences Network project (www.geongrid.org) has been developing cyberinfrastructure for data sharing in the Earth Science community based on a service-oriented architecture. The project defines a standard "software stack", which includes a standardized set of software modules and corresponding service interfaces. The system employs Grid certificates for distributed user authentication. The GEON Portal provides online access to these services via a set of portlets. This service-oriented approach has enabled the GEON network to easily expand to new sites and deploy the same infrastructure in new projects. To facilitate interoperation with other distributed geoinformatics environments, service standards are being defined and implemented for catalog services and federated search across distributed catalogs. The need arises because there may be multiple metadata catalogs in a distributed system, for example, for each institution, agency, geographic region, and/or country. Ideally, a geoinformatics user should be able to search across all such catalogs by making a single search request. In this paper, we describe our implementation for such a search capability across federated metadata catalogs in the GEON service-oriented architecture. The GEON catalog can be searched using spatial, temporal, and other metadata-based search criteria. The search can be invoked as a Web service and, thus, can be imbedded in any software application. The need for federated catalogs in GEON arises because, (i) GEON collaborators at the University of Hyderabad, India have deployed their own catalog, as part of the iGEON-India effort, to register information about local resources for broader access across the network, (ii) GEON collaborators in the GEO Grid (Global Earth Observations Grid) project at AIST, Japan have implemented a catalog for their ASTER data products, and (iii) we have recently deployed a search service to access all data products from the EarthScope project in the US

  4. The dual role of iNOS in cancer☆

    PubMed Central

    Vanini, Frederica; Kashfi, Khosrow; Nath, Niharika

    2015-01-01

    Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous free radical whose predominant functions is that of a messenger through cGMP. In mammals, NO is synthesized by the enzyme nitric oxide synthase (NOS) of which there are three isoforms. Neuronal (nNOS, NOS1) and endothelial (eNOS, NOS3) are constitutive calcium-dependent forms of the enzyme that regulate neural and vascular function respectively. The third isoform (iNOS, NOS2), is calcium-independent and is inducible. In many tumors, iNOS expression is high, however, the role of iNOS during tumor development is very complex and quite perplexing, with both promoting and inhibiting actions having been described. This review will aim to summarize the dual actions of iNOS-derived NO showing that the microenvironment of the tumor is a contributing factor to these observations and ultimately to cellular outcomes. PMID:26335399

  5. iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.

    PubMed

    Fujii, Naoto; Meade, Robert D; Alexander, Lacy M; Akbari, Pegah; Foudil-Bey, Imane; Louie, Jeffrey C; Boulay, Pierre; Kenny, Glen P

    2016-02-01

    Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate inducible NOS (iNOS), which may attenuate sweating and cutaneous vasodilator responses. We hypothesized that iNOS inhibition would augment sweating and cutaneous vasodilation in exercising older adults. Physically active younger (n = 12, 23 ± 4 yr) and older (n = 12, 60 ± 6 yr) adults performed two 30-min bouts of cycling at a fixed rate of metabolic heat production (400 W) in the heat (35°C). Sweat rate and cutaneous vascular conductance (CVC) were evaluated at four intradermal microdialysis sites with: 1) lactated Ringer (control), 2) nNOS inhibitor (nNOS-I, NPLA), 3) iNOS inhibitor (iNOS-I, 1400W), or 4) eNOS inhibitor (eNOS-I, LNAA). In younger adults during both exercise bouts, all inhibitors decreased sweating relative to control, albeit a lower sweat rate was observed at iNOS-I compared with eNOS-I and nNOS-I sites (all P < 0.05). CVC at the eNOS-I site was lower than control in younger adults throughout the intermittent exercise protocol (all P < 0.05). In older adults, there were no differences between control and iNOS-I sites for sweating and CVC during both exercise bouts (all P > 0.05). We show that iNOS and eNOS are the main contributors to NOS-dependent sweating and cutaneous vasodilation, respectively, in physically active younger adults exercising in the heat, and that iNOS inhibition does not alter sweating or cutaneous vasodilation in exercising physically active older adults.

  6. iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat

    PubMed Central

    Fujii, Naoto; Meade, Robert D.; Alexander, Lacy M.; Akbari, Pegah; Foudil-bey, Imane; Louie, Jeffrey C.; Boulay, Pierre

    2015-01-01

    Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate inducible NOS (iNOS), which may attenuate sweating and cutaneous vasodilator responses. We hypothesized that iNOS inhibition would augment sweating and cutaneous vasodilation in exercising older adults. Physically active younger (n = 12, 23 ± 4 yr) and older (n = 12, 60 ± 6 yr) adults performed two 30-min bouts of cycling at a fixed rate of metabolic heat production (400 W) in the heat (35°C). Sweat rate and cutaneous vascular conductance (CVC) were evaluated at four intradermal microdialysis sites with: 1) lactated Ringer (control), 2) nNOS inhibitor (nNOS-I, NPLA), 3) iNOS inhibitor (iNOS-I, 1400W), or 4) eNOS inhibitor (eNOS-I, LNAA). In younger adults during both exercise bouts, all inhibitors decreased sweating relative to control, albeit a lower sweat rate was observed at iNOS-I compared with eNOS-I and nNOS-I sites (all P < 0.05). CVC at the eNOS-I site was lower than control in younger adults throughout the intermittent exercise protocol (all P < 0.05). In older adults, there were no differences between control and iNOS-I sites for sweating and CVC during both exercise bouts (all P > 0.05). We show that iNOS and eNOS are the main contributors to NOS-dependent sweating and cutaneous vasodilation, respectively, in physically active younger adults exercising in the heat, and that iNOS inhibition does not alter sweating or cutaneous vasodilation in exercising physically active older adults. PMID:26586908

  7. Assisted Living Federation of America

    MedlinePlus

    ... Logos Membership FAQs Advocacy Advocacy Top Trending Issues Silver PAC Federal Public Policy State Regulations and Licensing ... Argentum Member Pledge Advocacy Advocacy Top Trending Issues Silver PAC Argentum Advocates Cobb Cup Federal Public Policy ...

  8. Eliminating the Federal Thrift Charter

    DTIC Science & Technology

    1997-06-01

    FDIC), the Office of the Comptroller of the Currency (OCC), the Federal Reserve , and the Office of Thrift Supervision (OTS). (See Table 1 for a list...the FDIC is the primary federal regulator for state-chartered commercial banks that are not members of the Federal Reserve System. It is also the...commercial bank regulators are the Office of the Comptroller of the Currency and the Federal Reserve . The OCC, established in 1863 by the National Currency

  9. An Xrootd Italian Federation

    NASA Astrophysics Data System (ADS)

    Boccali, T.; Donvito, G.; Diacono, D.; Marzulli, G.; Pompili, A.; Della Ricca, G.; Mazzoni, E.; Argiro, S.; Gregori, D.; Grandi, C.; Bonacorsi, D.; Lista, L.; Fabozzi, F.; Barone, L. M.; Santocchia, A.; Riahi, H.; Tricomi, A.; Sgaravatto, M.; Maron, G.

    2014-06-01

    The Italian community in CMS has built a geographically distributed network in which all the data stored in the Italian region are available to all the users for their everyday work. This activity involves at different level all the CMS centers: the Tier1 at CNAF, all the four Tier2s (Bari, Rome, Legnaro and Pisa), and few Tier3s (Trieste, Perugia, Torino, Catania, Napoli, ...). The federation uses the new network connections as provided by GARR, our NREN (National Research and Education Network), which provides a minimum of 10 Gbit/s to all the sites via the GARR-X[2] project. The federation is currently based on Xrootd[1] technology, and on a Redirector aimed to seamlessly connect all the sites, giving the logical view of a single entity. A special configuration has been put in place for the Tier1, CNAF, where ad-hoc Xrootd changes have been implemented in order to protect the tape system from excessive stress, by not allowing WAN connections to access tape only files, on a file-by-file basis. In order to improve the overall performance while reading files, both in terms of bandwidth and latency, a hierarchy of xrootd redirectors has been implemented. The solution implemented provides a dedicated Redirector where all the INFN sites are registered, without considering their status (T1, T2, or T3 sites). An interesting use case were able to cover via the federation are disk-less Tier3s. The caching solution allows to operate a local storage with minimal human intervention: transfers are automatically done on a single file basis, and the cache is maintained operational by automatic removal of old files.

  10. The Federal Air Pollution Program.

    ERIC Educational Resources Information Center

    National Air Pollution Control Administration (DHEW), Washington, DC.

    Described is the Federal air pollution program as it was in 1967. The booklet is divided into these major topics: History of the Federal Program; Research; Assistance to State and Local Governments; Abatement and Prevention of Air Pollution; Control of Motor Vehicle Pollution; Information and Education; and Conclusion. Federal legislation has…

  11. The Federal Role in Education

    ERIC Educational Resources Information Center

    Hill, Paul T.

    2000-01-01

    In this paper, the author discusses the federal role in education, which raises fundamental questions about how federal programs affect the schools. He suggests principles for a new federal role and shows how government policies have made schools more formal and complex; engineered political pressures that distorted schools' operations and…

  12. Science in the Federal Government.

    ERIC Educational Resources Information Center

    Thibodeau, Sharon Gibbs

    1985-01-01

    Examines the realm of science and the federal government made evident in the 1950s by A. Hunter Dupree's classic work on the subject. Federal science before 1940, federal science since 1940, and sources of historical materials are among the major areas considered. (JN)

  13. A Scallop Nitric Oxide Synthase (NOS) with Structure Similar to Neuronal NOS and Its Involvement in the Immune Defense

    PubMed Central

    Jiang, Qiufen; Zhou, Zhi; Wang, Leilei; Wang, Lingling; Yue, Feng; Wang, Jingjing; Song, Linsheng

    2013-01-01

    Background Nitric oxide synthase (NOS) is responsible for synthesizing nitric oxide (NO) from L-arginine, and involved in multiple physiological functions. However, its immunological role in mollusc was seldom reported. Methodology In the present study, an NOS (CfNOS) gene was identified from the scallop Chlamys farreri encoding a polypeptide of 1486 amino acids. Its amino acid sequence shared 50.0~54.7, 40.7~47.0 and 42.5~44.5% similarities with vertebrate neuronal (n), endothelial (e) and inducible (i) NOSs, respectively. CfNOS contained PDZ, oxygenase and reductase domains, which resembled those in nNOS. The CfNOS mRNA transcripts expressed in all embryos and larvae after the 2-cell embryo stage, and were detectable in all tested tissues with the highest level in the gonad, and with the immune tissues hepatopancreas and haemocytes included. Moreover, the immunoreactive area of CfNOS distributed over the haemocyte cytoplasm and cell membrane. After LPS, β-glucan and PGN stimulation, the expression level of CfNOS mRNA in haemocytes increased significantly at 3 h (4.0-, 4.8- and 2.7-fold, respectively, P < 0.01), and reached the peak at 12 h (15.3- and 27.6-fold for LPS and β-glucan respectively, P < 0.01) and 24 h (17.3-fold for PGN, P < 0.01). In addition, TNF-α also induced the expression of CfNOS, which started to increase at 1 h (5.2-fold, P < 0.05) and peaked at 6 h (19.9-fold, P < 0.01). The catalytic activity of the native CfNOS protein was 30.3 ± 0.3 U mgprot-1, and it decreased significantly after the addition of the selective inhibitors of nNOS and iNOS (26.9 ± 0.4 and 29.3 ± 0.1 U mgprot-1, respectively, P < 0.01). Conclusions These results suggested that CfNOS, with identical structure with nNOS and similar enzymatic characteristics to nNOS and iNOS, played the immunological role of iNOS to be involved in the scallop immune defense against PAMPs and TNF-α. PMID:23922688

  14. Federal Republic of Germany.

    PubMed

    1987-05-01

    The population of the Federal Republic of Germany (FRG) was an estimated 61 million (including West Berlin) in 1986 and is in the process of declining gradually as a result of low birth rates. The infant mortality rate is 11/1000, while life expectancy is 73.4 years for women and 67.2 years for men. Of the work force of 27.6 million, 5.4% are engaged in agriculture, 41.6% work in industry and commerce, 10% are employed by the government, and 42.7% are in the service sector. The gross national product was US$898.8 billion in 1986, with an annual growth rate of 2.6% and a per capita income of $10,680. The government is parliamentary and based on a democratic constitution emphasizing protection of individual liberty and divided power in a federal structure. Political life since the establishment of the FRG in 1949 has been characterized by remarkable stability and orderly succession. The FRG ranks among the most important economic powers in the world. The economy is largely export oriented, with 25-30% of the gross national product shipped abroad each year. Competition and free enterprise are fostered, but the state participates in the ownership and management of major sections of the economy, including public services. A major concern at present is the country's ability to adapt to new markets and to develop sophisticated technologies.

  15. Regulation of eNOS-derived superoxide by endogenous methylarginines.

    PubMed

    Druhan, Lawrence J; Forbes, Scott P; Pope, Arthur J; Chen, Chun-An; Zweier, Jay L; Cardounel, Arturo J

    2008-07-08

    The endogenous methylarginines, asymmetric dimethylarginine (ADMA) and N (G)-monomethyl- l-arginine (L-NMMA) regulate nitric oxide (NO) production from endothelial NO synthase (eNOS). Under conditions of tetrahydrobiopterin (BH 4) depletion eNOS also generates (*)O 2 (-); however, the effects of methylarginines on eNOS-derived (*)O 2 (-) generation are poorly understood. Therefore, using electron paramagnetic resonance spin trapping techniques we measured the dose-dependent effects of ADMA and L-NMMA on (*)O 2 (-) production from eNOS under conditions of BH 4 depletion. In the absence of BH 4, ADMA dose-dependently increased NOS-derived (*)O 2 (-) generation, with a maximal increase of 151% at 100 microM ADMA. L-NMMA also dose-dependently increased NOS-derived (*)O 2 (-), but to a lesser extent, demonstrating a 102% increase at 100 microM L-NMMA. Moreover, the native substrate l-arginine also increased eNOS-derived (*)O 2 (-), exhibiting a similar degree of enhancement as that observed with ADMA. Measurements of NADPH consumption from eNOS demonstrated that binding of either l-arginine or methylarginines increased the rate of NADPH oxidation. Spectrophotometric studies suggest, just as for l-arginine and L-NMMA, the binding of ADMA shifts the eNOS heme to the high-spin state, indicative of a more positive heme redox potential, enabling enhanced electron transfer from the reductase to the oxygenase site. These results demonstrate that the methylarginines can profoundly shift the balance of NO and (*)O 2 (-) generation from eNOS. These observations have important implications with regard to the therapeutic use of l-arginine and the methylarginine-NOS inhibitors in the treatment of disease.

  16. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  17. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  18. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  19. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  20. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  1. Face and Emotion Recognition in MCDD versus PDD-NOS

    ERIC Educational Resources Information Center

    Herba, Catherine M.; de Bruin, Esther; Althaus, Monika; Verheij, Fop; Ferdinand, Robert F.

    2008-01-01

    Previous studies indicate that Multiple Complex Developmental Disorder (MCDD) children differ from PDD-NOS and autistic children on a symptom level and on psychophysiological functioning. Children with MCDD (n = 21) and PDD-NOS (n = 62) were compared on two facets of social-cognitive functioning: identification of neutral faces and facial…

  2. 75 FR 38999 - Federal Perkins Loan Program: Federal Family Education Loan Program and William D. Ford Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF EDUCATION Federal Perkins Loan Program: Federal Family Education Loan Program and William D. Ford Federal Direct Loan Program AGENCY: Office of Postsecondary Education, Department of Education. ACTION:...

  3. Expression of nNOS in the human larynx.

    PubMed

    Şelaru, Mircea; Rusu, Mugurel Constantin; Jianu, Adelina Maria

    2015-09-01

    Although intrinsic laryngeal neurons and ganglia have been studied in various species, they have been overlooked in humans. We aimed to investigate the presence of intrinsic laryngeal neurons in humans and, if present, to analyze their neuronal nitric oxide synthase (nNOS) expression. An immunohistochemical study using anti-nNOS antibodies was performed on samples obtained from four cadavers. Intrinsic laryngeal nNOS+ neurons were assessed in the submucosal layer, but nNOS+ nerves were found in all histological layers of the larynx. nNOS expression was also found in striated muscle fibers of larynx. This might reveal the anatomical basis of an upwards extension of the nonadrenergic noncholinergic system in human airways, but further experiments are needed to assess an exact role of NO influence on neural transmission and muscular functions of human larynx.

  4. DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL

    PubMed Central

    Doursout, Marie-Francoise; Oguchi, Takeshi; Fischer, Uwe M.; Liang, YangYan; Chelly, Brice; Hartley, Craig J.; Chelly, Jacques E.

    2012-01-01

    Sepsis is a major cause of morbidity and mortality. NO, an endogenous vasodilator, has been associated with the hypotension, catecholamine hyporesponsiveness, and myocardial depression of septic shock. Although iNOS is thought to be responsible for the hypotension and loss of vascular tone occurring several hours after endotoxin administration, little is known on the effects of constitutive eNOS on LPS-induced organ dysfunction. This study assessed the distribution of eNOS and iNOS in various vascular beds in conscious pigs challenged with LPS. Cardiac and regional hemodynamic parameters were recorded over 8 h in the presence and absence of aminoguanidine, a rather selective inhibitor of iNOS activity, and N-methyl-L-arginine, a nonspecific NOS inhibitor. Our data show that LPS-induced cardiac depression was associated with coronary, renal, and mesenteric vasoconstrictions and a hepatic vasodilatation. LPS also induced increases in eNOS in the heart and lungs, whereas iNOS was mostly detected in the liver. Nitrotyrosine formation was mainly detected in the lungs, with traces in the kidney, liver, and gut. Accordingly, our results suggest that the early decrease in blood pressure and cardiac depression are likely due to activated eNOS, whereas both isoforms are involved in the hepatic vasodilation. In contrast, carotid, coronary, mesenteric, and renal vasoconstrictions were significant at 5 and/or 6 h after LPS infusion, suggesting that NO is not the primary mediator, facilitating and/or unmasking the release of vasoconstrictor mediators. Consequently, developing newer tissue- or isoform-specific NOS inhibitors can lead to novel therapeutic agents in septic shock. PMID:17909454

  5. Vascular nitric oxide: Beyond eNOS.

    PubMed

    Zhao, Yingzi; Vanhoutte, Paul M; Leung, Susan W S

    2015-10-01

    As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources in the blood vessel wall. NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP), although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA) or production of cyclic inosine monophosphate (cIMP)] also can be involved. In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS) but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite. Dysfunction in the production and/or the bioavailability of NO characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis.

  6. 41 CFR 102-79.40 - Can Federal agencies allot space in Federal buildings to Federal credit unions?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Can Federal agencies... Credit Unions § 102-79.40 Can Federal agencies allot space in Federal buildings to Federal credit unions? Yes, in accordance with 12 U.S.C. 1770, Federal agencies may allot space in Federal buildings...

  7. 41 CFR 102-79.40 - Can Federal agencies allot space in Federal buildings to Federal credit unions?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Can Federal agencies... Credit Unions § 102-79.40 Can Federal agencies allot space in Federal buildings to Federal credit unions? Yes, in accordance with 12 U.S.C. 1770, Federal agencies may allot space in Federal buildings...

  8. Advancing the Perceptions of the Nature of Science (NOS): Integrating Teaching the NOS in a Science Content Course

    ERIC Educational Resources Information Center

    Aflalo, Ester

    2014-01-01

    Background: Understanding the nature of science (NOS) has been a key objective in teaching sciences for many years. Despite the importance of this goal it is, until this day, a complex challenge that we are far from achieving. Purpose: The study was conducted in order to further the understanding of the NOS amongst preservice teachers. It explores…

  9. 75 FR 18014 - Federal Highway Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Highway Administration AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of...: Federal Highway Administration, Kentucky Division: Mr. Greg Rawlings, Transportation Specialist, 330...

  10. 78 FR 9771 - Federal Highway Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... Federal Highway Administration Notice of Final Federal Agency Action on Proposed Transportation Project in Illinois and Indiana AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of limitation on..., Federal Highway Administration, 3250 Executive Park Drive, Springfield, Illinois 62703, Phone: (217)...

  11. 78 FR 41183 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Meeting: RTCA Program Management Committee AGENCY: Federal Aviation.... Paige Williams, Management Analyst, NextGen, Business Operations Group, Federal Aviation...

  12. Federal Buildings Supplemental Survey 1993

    SciTech Connect

    1995-11-01

    The Energy Information Administration (EIA) of the US Department of Energy (DOE) is mandated by Congress to be the agency that collects, analyzes, and disseminates impartial, comprehensive data about energy including the volume consumed, its customers, and the purposes for which it is used. The Federal Buildings Supplemental Survey (FBSS) was conducted by EIA in conjunction with DOE`s Office of Federal Energy Management Programs (OFEMP) to gain a better understanding of how Federal buildings use energy. This report presents the data from 881 completed telephone interviews with Federal buildings in three Federal regions. These buildings were systematically selected using OFEMP`s specifications; therefore, these data do not statistically represent all Federal buildings in the country. The purpose of the FBSS was threefold: (1) to understand the characteristics of Federal buildings and their energy use; (2) to provide a baseline in these three Federal regions to measure future energy use in Federal buildings as required in EPACT; and (3) to compare building characteristics and energy use with the data collected in the CBECS.

  13. Federal Environmental Permitting Handbook

    SciTech Connect

    Not Available

    1991-05-01

    The handbook consists of eight chapters addressing permitting and licensing requirements under the Resource Conservation and Recovery Act (RCRA), the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, as amended by the Superfund Amendments and Reauthorization Act of 1986 (CERCLA/SARA), the Atomic Energy Act (AEA), the Clean Air Act (CAA), the Clean Water Act (CWA), the Federal Insectide, Fungicide, and Rodenticide Act (FIFRA), the Safe Drinking Water Act (SDWA), and the Toxic Substances Control Act (TSCA). Each chapter consists of: (1) an introduction to the statute and permitting requirements; (2) a diagram illustrating the relationship between permitting requirements under the statute being discussed and permitting requirements from other environmental statutes which may have to be addressed when applying for a particular permit (e.g., when applying for a RCRA permit, permits and permit applications under the CWA, CAA, SDWA, etc. would have to be listed in the RCRA permit application); and, (3) a compilation of the permitting requirements for the regulatory program resulting from the statute. In addition, the Handbook contains a permitting keyword index and a listing of hotline telephone numbers for each of the statutes.

  14. Helping Federal Policymakers Understand and Support Data Literacy. Federal Spotlight

    ERIC Educational Resources Information Center

    Data Quality Campaign, 2014

    2014-01-01

    Current federal and state policies focus on improved results for students through quality teaching. Strategies in school improvement plans, data-driven teacher evaluation, assessments and rigorous standards, competency-based learning, and innovative digital platforms make teacher data use essential. While state and federal policies are asking…

  15. Federal Research: Peer Review Practices at Federal Science Agencies Vary.

    DTIC Science & Technology

    1999-03-01

    traditionally relied on independent reviews by peers. This report responds to your request that we study the peer review and other quality assurance processes...by peer review , (2) describe the federal government’s peer review policy, (3) describe the peer review practices of 12 federal agencies that conduct

  16. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions About Using History of Science to Teach NOS

    NASA Astrophysics Data System (ADS)

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-05-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing biology teachers' understanding of NOS, and their perceptions about using HOS to teach NOS. These teachers ( N = 8), enrolled in a professional development program in Chile are, according to the national curriculum, expected to teach NOS, but have no specific NOS and HOS training. Teachers' views of NOS were assessed using the VNOS-D+ questionnaire at the beginning and at the end of two modules about science instruction and NOS. Both the pre- and the post-test were accompanied by interviews, and in the second session we collected information about teachers' perceptions of which interventions had been more significant in changing their views on NOS. Finally, the teachers also had to prepare a lesson plan for teaching NOS that included HOS. Some of the most important study results were: significant improvements were observed in teachers' understanding of NOS, although they assigned different levels of importance to HOS in these improvements; and although the teachers improved their understanding of NOS, most had difficulties in planning lessons about NOS and articulating historical episodes that incorporated NOS. The relationship between teachers' improved understanding of NOS and their instructional NOS skills is also discussed.

  17. The Federal Employees' Compensation Act.

    ERIC Educational Resources Information Center

    Nordlund, Willis J.

    1991-01-01

    The 1916 Federal Employees' Compensation Act is still the focal point around which the federal workers compensation program works today. The program has gone through many changes on its way to becoming a modern means of compensating workers for job-related injury, disease, and death. (Author)

  18. Sustainability in Brazilian Federal Universities

    ERIC Educational Resources Information Center

    Palma, Lisiane Celia; de Oliveira, Lessandra M.; Viacava, Keitiline R.

    2011-01-01

    Purpose: The purpose of this paper is to identify the number of courses related to sustainability offered in bachelor degree programs of business administration in Brazilian federal universities. Design/methodology/approach: An exploratory research was carried out based on a descriptive scope. The process of mapping federal universities in Brazil…

  19. Federal, State, and Local regulations

    SciTech Connect

    Kelly, J.M.; Brandenburg, B.L. )

    1991-08-01

    This article is a review of federal, state, and local regulations pertinent treatment of leachate from hazardous materials landfills in California. The topics covered include under federal regulations: pretreatment, whole-effluent toxicity, hazardous waste regulation; under state regulations: hazardous waste regulations, air toxics, environmental quality act; under local regulations: local limits, toxicity-regional water quality board, air emissions and district code.

  20. Federal Funding in the Delta.

    ERIC Educational Resources Information Center

    Reeder, Richard J.; Calhoun, Samuel D.

    2002-01-01

    The Lower Mississippi Delta region, especially the rural Delta, faces many economic challenges. The rural Delta has received much federal aid in basic income support and funding for human resource development, but less for community resource programs, which are important for economic development. Federal aid to the Delta is analyzed in terms of…

  1. When Federalism Works. Final Report.

    ERIC Educational Resources Information Center

    Peterson, Paul E.; And Others

    A study of the implementation of six major federal education policies in four urban school districts (Baltimore, Maryland; Milwaukee, Wisconsin; San Diego, California; and Dade County, Florida) generally supported a new theory of federalism. Research data were drawn from statistical reports and from interviews with over 150 persons at local,…

  2. Telecommuting in the Federal Workforce

    DTIC Science & Technology

    2001-12-01

    Act under the Truman Administration. The Hoover Administration recommended examining ways to improve the administrative services of the Federal...www.businessweek.com/1998/41/b3599150.htm 53. O’Hara, Colleen , and Haubold, Natasha, Federal Computer Week, “Telecommuting Hits a Roadblock,” March

  3. Regulation of eNOS enzyme activity by posttranslational modification.

    PubMed

    Heiss, Elke H; Dirsch, Verena M

    2014-01-01

    The regulation of endothelial NO synthase (eNOS) employs multiple different cellular control mechanisms impinging on level and activity of the enzyme. This review aims at summarizing the current knowledge on the posttranslational modifications of eNOS, including acylation, nitrosylation, phosphorylation, acetylation, glycosylation and glutathionylation. Sites, mediators and impact on enzyme localization and activity of the single modifications will be discussed. Moreover, interdependence, cooperativity and competition between the different posttranslational modifications will be elaborated with special emphasis on the susceptibility of eNOS to metabolic cues.

  4. Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs.

    PubMed

    Ben Ali Gannoun, Marwa; Zitouni, Hedia; Raguema, Nozha; Maleh, Wided; Gris, Jean-Christophe; Almawi, Wassim; Mahjoub, Touhami

    2015-09-15

    We investigated the association of endothelial nitric oxide synthase (NOS3) polymorphisms -786T>C, 27-bp repeat 4b/4a, and Glu298Asp with preeclampsia (PE). This was a case-control study involving 345 unrelated Tunisian women with PE and 289 unrelated age- and ethnically matched control women. The -786C allele was significantly increased in PA patients when compared to healthy controls (P=0.015). In contrast, MAF of Glu298Asp (P=0.103) and 4b/4a (P=0.168) were not significantly different between the study groups. Higher frequencies of heterozygous Glu298/298Asp and homozygous -786T/-786T genotypes were seen in PE cases compared to healthy subjects. The combination of genotypes 221 (-786T>C, Glu298Asp, 4a/4a) was more in PE cases compared with control women (17.68% vs. 8.36%; P=0.029). Multivariate regression analysis confirmed this association. Genetic variation at the NOS3 locus represents a genetic risk factor for increased susceptibility to PE.

  5. Molecular characterization of nosRZDFYLX genes coding for denitrifying nitrous oxide reductase of Bradyrhizobium japonicum.

    PubMed

    Velasco, Leonardo; Mesa, Socorro; Xu, Chang-Ai; Delgado, María J; Bedmar, Eulogio J

    2004-04-01

    The nosRZDFYLX gene cluster for the respiratory nitrous oxide reductase from Bradyrhizobium japonicum strain USDA110 has been cloned and sequenced. Seven protein coding regions corresponding to nosR, nosZ, the structural gene, nosD, nosF, nosY, nosL, and nosX were detected. The deduced amino acid sequence exhibited a high degree of similarity to other nitrous oxide reductases from various sources. The NosZ protein included a signal peptide for protein export. Mutant strains carrying either a nosZ or a nosR mutation accumulated nitrous oxide when cultured microaerobically in the presence of nitrate. Maximal expression of a P nosZ-lacZ fusion in strain USDA110 required simultaneously both low level oxygen conditions and the presence of nitrate. Microaerobic activation of the fusion required FixLJ and FixK(2).

  6. The effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidney.

    PubMed

    Tastekin, Ebru; Palabiyik, Orkide; Ulucam, Enis; Uzgur, Selda; Karaca, Aziz; Vardar, Selma Arzu; Yilmaz, Ali; Aydogdu, Nurettin

    2016-08-01

    Long-term effects of high protein diets (HPDs) on kidneys are still not sufficiently studied. Irisin which increases oxygen consumption and thermogenesis in white fat cells was shown in skeletal muscles and many tissues. Nitric oxide synthases (NOS) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. We aimed to investigate the effects of HPD, irisin and NO expression in kidney and relation of them with exercise and among themselves. Animals were grouped as control, exercise, HPD and exercise combined with HPD (exercise-HPD). Rats were kept on a HPD for 5 weeks and an exercise program was given them as 5 exercise and 2 rest days per week exercising on a treadmill with increasing speed and angle. In our study, while HPD group had similar total antioxidant capacity (TAC) levels with control group, exercise and exercise-HPD groups had lower levels (p < 0.05). Kidneys of exercising rats had no change in irisin or eNOS expression but their iNOS expression had increased (p < 0.001). HPD-E group has not been observed to cause kidney damage and not have a significant effect on rat kidney irisin, eNOS, or iNOS expression. Localization of irisin, eNOS, and iNOS staining in kidney is highly selective and quite clear in this study. Effects of exercise and HPD on kidney should be evaluated with different exercise protocols and contents of the diet. İrisin, eNOS, and iNOS staining localizations should be supported with various research studies.

  7. eNOS/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia

    PubMed Central

    Du, L; He, F; Kuang, L; Tang, W; Li, Y; Chen, D

    2017-01-01

    Disruption of nitric oxide pathway and endoplasmic reticulum (ER) stress had been observed in preeclampsia (PE). However, the correlation and overall detailed expression profiles of ER stress-related markers and endothelial nitric oxide synthase/inducible nitric oxide synthase (eNOS/iNOS) in patients with PE were poorly understood. In this study, placental protein expression of ER stress-related markers as well as eNOS/iNOS in normotensive control (n=32) and PE pregnancies (n=32) was examined by western blot. In addition, apoptosis was detected by terminal deoxynucleotidyl transferase-mediated nick-end labelling (TUNEL) staining in placentas. Compared with control, we found elevated ER stress response was agreeable with iNOS upregulation in placenta tissue of PE patients. Placental protein expression of ER stress-related markers, including GRP78, GRP94, p-PERK, eIF2a, p-eIF2a, XBP1, CHOP, Ire1, p-Ire1 and iNOS, was higher, and eNOS expression was lower in PE (P<0.05 for all); however, the expression of ATF6 and PERK was similar in the PE and control groups. Upregulation of CHOP and iNOS was consistent of apoptosis increasing indicated by TUNEL staining and caspase 4 expression upregulation in PE placenta. Our datas suggest that the exaggerated ER stress response and upregulated iNOS are probably associated with increased apoptosis in placenta of PE patients and may contribute to the pathophysiology of PE. PMID:27030287

  8. Differential roles of iNOS and nNOS at rostral ventrolateral medulla during experimental endotoxemia in the rat.

    PubMed

    Chan, J Y; Wang, S H; Chan, S H

    2001-01-01

    We investigated the differential contribution of inducible and neuronal nitric oxide synthase (iNOS and nNOS) at the rostral ventrolateral medulla (RVLM) to endotoxemia induced by E. coli lipopolysaccharide (LPS). In Sprague-Dawley rats maintained under propofol anesthesia, i.v. administration of LPS (15, 30, or 45 mg/kg) induced a reduction (phase I), followed by an augmentation (phase II) and a secondary decrease (phase III) in the power density of the vasomotor components (0-0.8 Hz) in systemic arterial pressure (SAP) signals. LPS also induced an immediate hypotension, followed by a rebound increase and a secondary decrease in SAP. In addition, the level of iNOS mRNA exhibited a significant surge that began with phase I endotoxemia, reaching progressively its peak at phase III. Discernible down-regulation of nNOS mRNA was not detected until the last phase of endotoxemia. Pretreatment with microinjection of the selective iNOS inhibitor, aminoguanidine (250 pmol), into the bilateral RVLM significantly prolonged phases II and III endotoxemia, blunted the initial and secondary hypotension, and antagonized the upregulation of iNOS mRNA. Similar pretreatment with the selective nNOS inhibitor, 7-nitroindazole (1 pmol), on the other hand, discernibly shortened phase II and prolonged phase III endotoxemia, and induced progressive hypotension by antagonizing the rebound increase in SAP. We conclude that the relative prevalence of functional expression and molecular synthesis of iNOS over nNOS in the RVLM may be a crucial determinant for the reduction or loss in power density of the vasomotor components of SAP signals during experimental endotoxemia.

  9. Interior view of connector between Building Nos. 608 & 609 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior view of connector between Building Nos. 608 & 609 (HABS CO-172-DS) facing north - Fitzsimons General Hospital, Neuropsychiatric Ward, Southeast Corner of East Nineteenth Avenue & Wheeling Street (formerly South Van Valzuh Street), Aurora, Adams County, CO

  10. Los Angeles County Poor Farm, Patient Ward Nos. 210 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Los Angeles County Poor Farm, Patient Ward Nos. 210 & 211 - Type B Plan, 7601 Imperial Highway; bounded by Esperanza Street, Laurel Street, Flores Street, and Descanso Street, Downey, Los Angeles County, CA

  11. 5. VIEW OF NORTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW OF NORTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. 10 AND 9 FROM CENTRAL STAIRWAY. LOOKING NORTH. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

  12. 6. VIEW OF SOUTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW OF SOUTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. 12, 13, AND 14 FROM CENTRAL STAIRWAY. LOOKING SOUTH. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

  13. 9. DETAIL OF BENTS NOS 3 AND 4. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. DETAIL OF BENTS NOS 3 AND 4. VIEW TO NORTH-NORTHEAST - Milwaukee Road Railroad Overpass, Spanning Chicago, Milwaukee, St. Paul, & Pacific Railroad Grade (Milwaukee Road) at Orange Street, Missoula, Missoula County, MT

  14. 11. BENTS NOS. 3 AND 2. VIEW TO SOUTHSOUTHWEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. BENTS NOS. 3 AND 2. VIEW TO SOUTH-SOUTHWEST - Milwaukee Road Railroad Overpass, Spanning Chicago, Milwaukee, St. Paul, & Pacific Railroad Grade (Milwaukee Road) at Orange Street, Missoula, Missoula County, MT

  15. Vault Area (original section), east corridor, looking north (Vault Nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Vault Area (original section), east corridor, looking north (Vault Nos. 1-9 - Fort McNair, Film Store House, Fort Lesley J. McNair, P Street between Third & Fourth Streets, Southwest, Washington, District of Columbia, DC

  16. 36. ISLAND PLANT: Nos. 1 AND 2 TWENTYSIX INCH HORIZONTAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. ISLAND PLANT: Nos. 1 AND 2 TWENTY-SIX INCH HORIZONTAL SAMSON TURBINES - American Falls Water, Power & Light Company, Island Power Plant, Snake River, below American Falls Dam, American Falls, Power County, ID

  17. 37. ISLAND PLANT: Nos. 1 AND 2 TWENTYSIX INCH SPECIAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. ISLAND PLANT: Nos. 1 AND 2 TWENTY-SIX INCH SPECIAL HORIZONTAL SAMSON TURBINE (RIVITED CASE) - American Falls Water, Power & Light Company, Island Power Plant, Snake River, below American Falls Dam, American Falls, Power County, ID

  18. 75 FR 14057 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-40; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... Federal Acquisition Regulation; Federal Acquisition Circular 2005-40: Introduction, Small Entity... Acquisition Regulation; Federal Acquisition Circular 2005-40; Introduction AGENCIES: Department of Defense...

  19. The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.

    PubMed

    Ortiz, Francisco; García, José A; Acuña-Castroviejo, Darío; Doerrier, Carolina; López, Ana; Venegas, Carmen; Volt, Huayqui; Luna-Sánchez, Marta; López, Luis C; Escames, Germaine

    2014-01-01

    While it is accepted that the high production of nitric oxide (NO˙) by the inducible nitric oxide synthase (iNOS) impairs cardiac mitochondrial function during sepsis, the role of neuronal nitric oxide synthase (nNOS) may be protective. During sepsis, there is a significantly increase in the expression and activity of mitochondrial iNOS (i-mtNOS), which parallels the changes in cytosolic iNOS. The existence of a constitutive NOS form (c-mtNOS) in heart mitochondria has been also described, but its role in the heart failure during sepsis remains unclear. Herein, we analyzed the changes in mitochondrial oxidative stress and bioenergetics in wild-type and nNOS-deficient mice during sepsis, and the role of melatonin, a known antioxidant, in these changes. Sepsis was induced by cecal ligation and puncture, and heart mitochondria were analyzed for NOS expression and activity, nitrites, lipid peroxidation, glutathione and glutathione redox enzymes, oxidized proteins, and respiratory chain activity in vehicle- and melatonin-treated mice. Our data show that sepsis produced a similar induction of iNOS/i-mtNOS and comparable inhibition of the respiratory chain activity in wild-type and in nNOS-deficient mice. Sepsis also increased mitochondrial oxidative/nitrosative stress to a similar extent in both mice strains. Melatonin administration inhibited iNOS/i-mtNOS induction, restored mitochondrial homeostasis in septic mice, and preserved the activity of nNOS/c-mtNOS. The effects of melatonin were unrelated to the presence or the absence of nNOS. Our observations show a lack of effect of nNOS on heart bioenergetic impairment during sepsis and further support the beneficial actions of melatonin in sepsis.

  20. State/Federal Regulatory Considerations

    EPA Pesticide Factsheets

    This page contains presentations from the Brown to Green: Make the Connection to Renewable Energy workshop held in Santa Fe, New Mexico, during December 10-11, 2008, regarding State/Federal Regulatory Considerations.

  1. Federal Firefighter Pay Equity Act

    THOMAS, 111th Congress

    Rep. Connolly, Gerald E. [D-VA-11

    2009-07-13

    07/31/2009 Referred to the Subcommittee on Federal Workforce, Post Office, and the District of Columbia. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  2. Federal Firefighter Pay Equity Act

    THOMAS, 112th Congress

    Rep. Connolly, Gerald E. [D-VA-11

    2011-03-14

    04/01/2011 Referred to the Subcommittee on Federal Workforce, U.S. Postal Service, and Labor Policy. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  3. Federal Employees Responsible Investment Act

    THOMAS, 112th Congress

    Rep. Langevin, James R. [D-RI-2

    2011-06-03

    06/20/2011 Referred to the Subcommittee on Federal Workforce, U.S. Postal Service, and Labor Policy . (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  4. 2016 Federal Green Challenge Awards

    EPA Pesticide Factsheets

    We are pleased to recognize the following participants in the FGC for their significant efforts in improving the sustainability of their facilities and for their leadership in reducing the environmental footprint of federal government activities.

  5. Federal Life Insurance Transparency Act

    THOMAS, 112th Congress

    Rep. Connolly, Gerald E. [D-VA-11

    2011-01-05

    02/08/2011 Referred to the Subcommittee on Federal Workforce, U.S. Postal Service, and Labor Policy . (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Federal Register. 12.1 Section 12.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  7. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Federal Register. 12.1 Section 12.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  8. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Federal Register. 12.1 Section 12.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  9. Federal Communications Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... Part XVIII Federal Communications Commission Semiannual Regulatory Agenda ] FEDERAL COMMUNICATIONS COMMISSION (FCC) FEDERAL COMMUNICATIONS COMMISSION 47 CFR Ch. I Unified Agenda of Federal Regulatory and Deregulatory Actions AGENCY: Federal Communications Commission. ACTION: Semiannual regulatory agenda. SUMMARY: Twice a year, in spring and...

  10. In vitro and in vivo induction and activation of nNOS by LPS in oligodendrocytes

    PubMed Central

    Yao, SY.; Ljunggren-Rose, A.; Chandramohan, N.; Whetsell, W.O.; Sriram, S.

    2014-01-01

    There are currently four known isoforms of nitric oxide synthase (NOS). Of these, neuronal NOS (nNOS) is known to be present exclusively in neurons, endothelial NOS (eNOS) in vascular endothelium, while the inducible form of NOS (iNOS) is known to be activated in oligodendrocytes, astrocytes and microglia. The fourth isoform, mitochondrial NOS (mtNOS), represents a post translational modification of nNOS. Using western blotting and real time-PCR, we show induction and activation of nNOS following culture of oligodendrocyte progenitor cells (OPC) with lipopolysaccharide (LPS). Activation of nNOS results in accumulation of peroxynitrite and tyrosine nitration of proteins in oligodendrocytes resulting in reduced cell viability. Injection of LPS in vivo into the corpus callosum of rats leads to the development of extensive demyelination of the white matter tracts. Immunostaining of regions close to the injection site shows the presence of nNOS, but not iNOS, in oligodendrocytes. Neither iNOS nor nNOS was seen in astrocytes in areas of demyelination. These studies suggest that activation of nNOS in oligodendrocytes leads to oligodendrocyte injury resulting in demyelination. PMID:20724006

  11. Mitigating earthquakes; the federal role

    USGS Publications Warehouse

    Press, F.

    1977-01-01

    With rapid approach of a capability to make reliable earthquake forecasts, it essential that the Federal Government play a strong, positive role in formulating and implementing plans to reduce earthquake hazards. Many steps are being taken in this direction, with the President looking to the Office of Science and Technology Policy (OSTP) in his Executive Office to provide leadership in establishing and coordinating Federal activities. 

  12. Federal Renewable Energy Screening Assistant

    SciTech Connect

    Shelpuk, B; Walker, A

    1994-10-01

    The Federal Renewable Energy Screening Assistant is a software tool to be used by energy auditors to prioritize future studies of potentially cost-effective renewable energy applications at federal facilities. This paper describes the structure and function of the tool, gives an inventory of renewable energy technologies represented in the tool, and briefly describes the algorithms used to rank opportunities by the savings-to-investment ratio.

  13. Federal Contractors and Sticky Costs

    DTIC Science & Technology

    2014-11-05

    NPS-CM-14-188 ACQUISITION RESEARCH PROGRAM SPONSORED REPORT SERIES Federal Contractors and Sticky Costs 5 November 2014 Stephen C. Hansen...average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed...Public Policy - iv - Naval Postgraduate School NPS-CM-14-188 Acquisition Research Program Sponsored Report Series Federal Contractors and

  14. Federal technology policy in transition

    SciTech Connect

    Carnes, K.H.

    1995-12-31

    This paper discusses federal energy and environmental policies and their impact on the U.S. economy. A brief history of the federal government`s role in developing scientific and technological infrastructure is given. Current trends in technology are summarized, with an emphasis on global aspects, and their impact on the economy is discussed. The need for a national technology policy, including continued research and development funding, is discussed and key elements of such a policy are outlined.

  15. Comparison of oxygen-induced radical intermediates in iNOS oxygenase domain with those from nNOS and eNOS.

    PubMed

    Berka, Vladimír; Liu, Wen; Wu, Gang; Tsai, Ah-Lim

    2014-10-01

    Inducible nitric-oxide synthase (iNOS) produces the reactive oxygen and nitrogen species (ROS/RNS) involved in bacteria killing and is crucial in the host defense mechanism. However, high level ROS/RNS can also be detrimental to normal cells and thus their production has to be tightly controlled. Availability or deficiency of tetrahydrobiopterin (BH4) cofactor and l-arginine substrate controls coupling or uncoupling of NOS catalysis. Fully coupled reaction, with abundant BH4 and l-arginine, produces NO whereas the uncoupled NOS (in the absence of BH4 and/or l-arginine) generates ROS/RNS. In the current work we focus on direct rapid freeze EPR to characterize the structure and kinetics of oxygen-induced radical intermediates produced by ferrous inducible NOS oxygenase domain (iNOSox) in the presence or absence of BH4 and/or l-arginine. Fully reconstituted iNOSox (+BH4, +L-Arg) forms a dimer and yields a typical BH4 radical that indicates coupled reaction. iNOSox (-BH4) remains mainly monomeric and produces exclusively superoxide, that is only marginally affected by the presence of l-arginine. iNOSox (+BH4, -L-Arg) exists as a monomer/dimer mixture and yields both BH4 radical and superoxide. Present study is a natural extension of our previous work on the ferrous endothelial NOSox (eNOSox) [V. Berka, G. Wu, H.C. Yeh, G. Palmer, A.L. Tsai, J. Biol. Chem. 279 (2004) 32243-32251] and ferrous neuronal NOSox (nNOSox) [V. Berka, L.H. Wang, A.L. Tsai, Biochemistry 47 (2008) 405-420]. Overall, our data suggests different regulatory roles of l-arginine and BH4 in the production of oxygen-induced radical intermediates in NOS isoforms which nicely serve individual functional role.

  16. Nitrous Oxide Reduction Kinetics Distinguish Bacteria Harboring Clade I NosZ from Those Harboring Clade II NosZ

    PubMed Central

    Nissen, Silke; Park, Doyoung; Sanford, Robert A.

    2016-01-01

    ABSTRACT Bacteria capable of reduction of nitrous oxide (N2O) to N2 separate into clade I and clade II organisms on the basis of nos operon structures and nosZ sequence features. To explore the possible ecological consequences of distinct nos clusters, the growth of bacterial isolates with either clade I (Pseudomonas stutzeri strain DCP-Ps1, Shewanella loihica strain PV-4) or clade II (Dechloromonas aromatica strain RCB, Anaeromyxobacter dehalogenans strain 2CP-C) nosZ with N2O was examined. Growth curves did not reveal trends distinguishing the clade I and clade II organisms tested; however, the growth yields of clade II organisms exceeded those of clade I organisms by 1.5- to 1.8-fold. Further, whole-cell half-saturation constants (Kss) for N2O distinguished clade I from clade II organisms. The apparent Ks values of 0.324 ± 0.078 μM for D. aromatica and 1.34 ± 0.35 μM for A. dehalogenans were significantly lower than the values measured for P. stutzeri (35.5 ± 9.3 μM) and S. loihica (7.07 ± 1.13 μM). Genome sequencing demonstrated that Dechloromonas denitrificans possessed a clade II nosZ gene, and a measured Ks of 1.01 ± 0.18 μM for N2O was consistent with the values determined for the other clade II organisms tested. These observations provide a plausible mechanistic basis for why the relative activity of bacteria with clade I nos operons compared to that of bacteria with clade II nos operons may control N2O emissions and determine a soil's N2O sink capacity. IMPORTANCE Anthropogenic activities, in particular fertilizer application for agricultural production, increase N2O emissions to the atmosphere. N2O is a strong greenhouse gas with ozone destruction potential, and there is concern that nitrogen may become the major driver of climate change. Microbial N2O reductase (NosZ) catalyzes N2O reduction to environmentally benign dinitrogen gas and represents the major N2O sink process. The observation that bacterial groups with clade I nosZ versus those

  17. Federal Utility Program Overview (Fact Sheet)

    SciTech Connect

    Not Available

    2009-07-01

    Fact sheet overview of the U.S. Department of Energy (DOE) Federal Energy Management Program's (FEMP) Federal Utility Program, including common contracts and services available to Federal agencies through local serving utilities.

  18. Final Federal Radon Action Plan Scorecard

    EPA Pesticide Factsheets

    This page provides information and a link to the draft Federal Radon Action Plan. It also contains a Federal Radon Action Plan Scorecard, a tool designed to display the current status of each federal agency commitments and outcomes to date.

  19. 75 FR 6433 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... Federal Aviation Administration Notice of Availability of a Draft Environmental Assessment and Public...: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Availability of a Draft Environmental... Chicago, Illinois. SUMMARY: The Federal Aviation Administration (FAA) proposes to fund, construct,...

  20. 76 FR 78966 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... Federal Aviation Administration Approval of Noise Compatibility Program for Kona International Airport at Keahole, Keahole, North Kona, HI AGENCY: Federal Aviation Administration, DOT. ACTION: Notice. SUMMARY: The Federal Aviation Administration (FAA) announces its findings on the noise compatibility...

  1. 76 FR 2745 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Eighty-Fourth Meeting: RTCA Special Committee 159: Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special...

  2. 78 FR 25337 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Operations Specifications AGENCY: Federal...

  3. 77 FR 64837 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Federal Aviation Administration Fourth Meeting: RTCA Special Committee 227, Standards of Navigation Performance AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION... 15, 2012. Kathy Hitt, Management Analyst, Business Operations Group, Federal Aviation...

  4. 77 FR 58817 - Notice of Proposed Information Collection Requests; Federal Student Aid; Federal Family...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... administrative requirements of the Federal Family Education Loan (FFEL) program. The information collection... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Notice of Proposed Information Collection Requests; Federal Student Aid; Federal Family Educational...

  5. Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers

    PubMed Central

    Lai, Li; Ghebremariam, Yohannes T.

    2016-01-01

    Insulin resistance syndrome (IRS) is a configuration of cardiovascular risk factors involved in the development of metabolic disorders including type 2 diabetes mellitus. In addition to diet, age, socioeconomic, and environmental factors, genetic factors that impair insulin signaling are centrally involved in the development and exacerbation of IRS. Genetic and pharmacological studies have demonstrated that the nitric oxide (NO) synthase (NOS) genes are critically involved in the regulation of insulin-mediated glucose disposal. The generation of NO by the NOS enzymes is known to contribute to vascular homeostasis including insulin-mediated skeletal muscle vasodilation and insulin sensitivity. By contrast, excessive inhibition of NOS enzymes by exogenous or endogenous factors is associated with insulin resistance (IR). Asymmetric dimethylarginine (ADMA) is an endogenous molecule that competitively inhibits all the NOS enzymes and contributes to metabolic perturbations including IR. The concentration of ADMA in plasma and tissue is enzymatically regulated by dimethylarginine dimethylaminohydrolase (DDAH), a widely expressed enzyme in the cardiovascular system. In preclinical studies, overexpression of DDAH has been shown to reduce ADMA levels, improve vascular compliance, and increase insulin sensitivity. This review discusses the feasibility of the NOS/DDAH pathway as a novel target to develop vasoprotective insulin sensitizers. PMID:26770984

  6. Expression analysis of NOS family and HSP genes during thermal stress in goat ( Capra hircus)

    NASA Astrophysics Data System (ADS)

    Yadav, Vijay Pratap; Dangi, Satyaveer Singh; Chouhan, Vikrant Singh; Gupta, Mahesh; Dangi, Saroj K.; Singh, Gyanendra; Maurya, Vijay Prakash; Kumar, Puneet; Sarkar, Mihir

    2016-03-01

    Approximately 50 genes other than heat shock protein (HSP) expression changes during thermal stress. These genes like nitric oxide synthase (NOS) need proper attention and investigation to find out their possible role in the adaptation to thermal stress in animals. So, the present study was undertaken to demonstrate the expressions of inducible form type II NOS (iNOS), endothelial type III NOS (eNOS), constitutively expressed enzyme NOS (cNOS), HSP70, and HSP90 in peripheral blood mononuclear cells (PBMCs) during different seasons in Barbari goats. Real-time polymerase chain reaction, western blot, and immunocytochemistry were applied to investigate messenger RNA (mRNA) expression, protein expression, and immunolocalization of examined factors. The mRNA and protein expressions of iNOS, eNOS, cNOS, HSP70, and HSP90 were significantly higher ( P < 0.05) during peak summer, and iNOS and eNOS expressions were also observed to be significantly higher ( P < 0.05) during peak winter season as compared with moderate season. The iNOS, eNOS, cNOS, HSP70, and HSP90 were mainly localized in plasma membrane and cytoplasm of PBMCs. To conclude, data generated in the present study indicate the possible involvement of the NOS family genes in amelioration of thermal stress so as to maintain cellular integrity and homeostasis in goats.

  7. Expression analysis of NOS family and HSP genes during thermal stress in goat (Capra hircus).

    PubMed

    Yadav, Vijay Pratap; Dangi, Satyaveer Singh; Chouhan, Vikrant Singh; Gupta, Mahesh; Dangi, Saroj K; Singh, Gyanendra; Maurya, Vijay Prakash; Kumar, Puneet; Sarkar, Mihir

    2016-03-01

    Approximately 50 genes other than heat shock protein (HSP) expression changes during thermal stress. These genes like nitric oxide synthase (NOS) need proper attention and investigation to find out their possible role in the adaptation to thermal stress in animals. So, the present study was undertaken to demonstrate the expressions of inducible form type II NOS (iNOS), endothelial type III NOS (eNOS), constitutively expressed enzyme NOS (cNOS), HSP70, and HSP90 in peripheral blood mononuclear cells (PBMCs) during different seasons in Barbari goats. Real-time polymerase chain reaction, western blot, and immunocytochemistry were applied to investigate messenger RNA (mRNA) expression, protein expression, and immunolocalization of examined factors. The mRNA and protein expressions of iNOS, eNOS, cNOS, HSP70, and HSP90 were significantly higher (P < 0.05) during peak summer, and iNOS and eNOS expressions were also observed to be significantly higher (P < 0.05) during peak winter season as compared with moderate season. The iNOS, eNOS, cNOS, HSP70, and HSP90 were mainly localized in plasma membrane and cytoplasm of PBMCs. To conclude, data generated in the present study indicate the possible involvement of the NOS family genes in amelioration of thermal stress so as to maintain cellular integrity and homeostasis in goats.

  8. Pedagogical Reflections by Secondary Science Teachers at Different NOS Implementation Levels

    NASA Astrophysics Data System (ADS)

    Herman, Benjamin C.; Clough, Michael P.; Olson, Joanne K.

    2015-10-01

    This study investigated what 13 secondary science teachers at various nature of science (NOS) instruction implementation levels talked about when they reflected on their teaching. We then determined if differences exist in the quality of those reflections between high, medium, and low NOS implementers. This study sought to answer the following questions: (1) What do teachers talk about when asked general questions about their pedagogy and NOS pedagogy and (2) what qualitative differences, if any, exist within variables across teachers of varying NOS implementation levels? Evidence derived from these teachers' reflections indicated that self-efficacy and perceptions of general importance for NOS instruction were poor indicators of NOS implementation. However, several factors were associated with the extent that these teachers implemented NOS instruction, including the utility value they hold for NOS teaching, considerations of how people learn, understanding of NOS pedagogy, and their ability to accurately and deeply self-reflect about teaching. Notably, those teachers who effectively implemented the NOS at higher levels value NOS instruction for reasons that transcend immediate instructional objectives. That is, they value teaching NOS for achieving compelling ends realized long after formal schooling (e.g., lifelong socioscientific decision-making for civic reasons), and they deeply reflect about how to teach NOS by drawing from research about how people learn. Low NOS implementers' simplistic notions and reflections about teaching and learning appeared to be impeding factors to accurate and consistent NOS implementation. This study has implications for science teacher education efforts that promote NOS instruction.

  9. Pedagogical Reflections by Secondary Science Teachers at Different NOS Implementation Levels

    NASA Astrophysics Data System (ADS)

    Herman, Benjamin C.; Clough, Michael P.; Olson, Joanne K.

    2017-02-01

    This study investigated what 13 secondary science teachers at various nature of science (NOS) instruction implementation levels talked about when they reflected on their teaching. We then determined if differences exist in the quality of those reflections between high, medium, and low NOS implementers. This study sought to answer the following questions: (1) What do teachers talk about when asked general questions about their pedagogy and NOS pedagogy and (2) what qualitative differences, if any, exist within variables across teachers of varying NOS implementation levels? Evidence derived from these teachers' reflections indicated that self-efficacy and perceptions of general importance for NOS instruction were poor indicators of NOS implementation. However, several factors were associated with the extent that these teachers implemented NOS instruction, including the utility value they hold for NOS teaching, considerations of how people learn, understanding of NOS pedagogy, and their ability to accurately and deeply self-reflect about teaching. Notably, those teachers who effectively implemented the NOS at higher levels value NOS instruction for reasons that transcend immediate instructional objectives. That is, they value teaching NOS for achieving compelling ends realized long after formal schooling (e.g., lifelong socioscientific decision-making for civic reasons), and they deeply reflect about how to teach NOS by drawing from research about how people learn. Low NOS implementers' simplistic notions and reflections about teaching and learning appeared to be impeding factors to accurate and consistent NOS implementation. This study has implications for science teacher education efforts that promote NOS instruction.

  10. Federal Resources for Sustainable Rural Communities

    EPA Pesticide Factsheets

    Federal Resources for Sustainable Rural Communities (2012) highlights federal resources rural communities can use to promote economic competitiveness, protect healthy environments, and enhance quality of life.

  11. 30 CFR 900.13 - Federal programs and Federal coal exploration programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Federal programs and Federal coal exploration... INTRODUCTION § 900.13 Federal programs and Federal coal exploration programs. The rules for each Federal program and Federal coal exploration program are codified below under the assigned part for the...

  12. 30 CFR 900.13 - Federal programs and Federal coal exploration programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Federal programs and Federal coal exploration... INTRODUCTION § 900.13 Federal programs and Federal coal exploration programs. The rules for each Federal program and Federal coal exploration program are codified below under the assigned part for the...

  13. 30 CFR 900.13 - Federal programs and Federal coal exploration programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Federal programs and Federal coal exploration... INTRODUCTION § 900.13 Federal programs and Federal coal exploration programs. The rules for each Federal program and Federal coal exploration program are codified below under the assigned part for the...

  14. 30 CFR 900.13 - Federal programs and Federal coal exploration programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Federal programs and Federal coal exploration... INTRODUCTION § 900.13 Federal programs and Federal coal exploration programs. The rules for each Federal program and Federal coal exploration program are codified below under the assigned part for the...

  15. 30 CFR 900.13 - Federal programs and Federal coal exploration programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Federal programs and Federal coal exploration... INTRODUCTION § 900.13 Federal programs and Federal coal exploration programs. The rules for each Federal program and Federal coal exploration program are codified below under the assigned part for the...

  16. Study of the cerrado vegetation in the Federal District area from orbital data. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Dejesusparada, N. (Principal Investigator); Aoki, H.; Dossantos, J. R.

    1980-01-01

    The physiognomic units of cerrado in the area of Distrito Federal (DF) were studied through the visual and automatic analysis of products provided by Multispectral Scanning System (MSS) of LANDSAT. The visual analysis of the multispectral images in black and white, at the 1:250,000 scale, was made based on the texture and tonal patterns. The automatic analysis of the compatible computer tapes (CCT) was made by means of IMAGE-100 system. The following conclusions were obtained: (1) the delimitation of cerrado vegetation forms can be made by the visual and automatic analysis; (2) in the visual analysis, the principal parameter used to discriminate the cerrado forms was the tonal pattern, independently of the year's seasons, and the channel 5 gave better information; (3) in the automatic analysis, the data of the four channels of MSS can be used in the discrimination of the cerrado forms; and (4) in the automatic analysis, the four channels combination possibilities gave more information in the separation of cerrado units when soil types were considered.

  17. Brown Norway rats show impaired nNOS-mediated information transfer in renal autoregulation.

    PubMed

    Wang, Xuemei; Cupples, William A

    2009-01-01

    Nonselective inhibition of NO synthase (NOS) augments myogenic autoregulation of renal blood flow (RBF) and profoundly reduces RBF. Previously in Wistar rats, we showed that augmented autoregulation, but not vasoconstriction, is duplicated by intrarenal inhibition of neuronal NOS (nNOS), whereas intrarenal inhibition of inducible NOS (iNOS) has no effect on RBF or on RBF dynamics. Thus macula densa nNOS transfers information from tubuloglomerular feedback to the afferent arteriole. This information flow requires that macula densa nNOS can sufficiently alter ambient NO concentration, that is, that endothelial NOS (eNOS) and iNOS do not alter local NO concentration. Because the Brown Norway rat often shows exaggerated responses to NOS inhibition and has peculiarities of renal autoregulation that are related to NO, we used this strain to study systemic and renal vascular responses to NOS inhibition. The first experiment showed transient blood pressure reduction by bolus i.v. acetylcholine that was dose-dependent in both strains and substantially prolonged in Brown Norway rats. The depressor response decayed more rapidly after nonselective NOS inhibition and the difference between strains was lost, indicating a greater activity of eNOS in Brown Norway rats. In Brown Norway rats, selective inhibition of iNOS reduced RBF (-16% +/- 7%) and augmented myogenic autoregulation, whereas nNOS inhibition reduced RBF (-25% +/- 4%) and did not augment myogenic autoregulation. The significant responses to intrarenal iNOS inhibition, the reduced modulation of autoregulation by nNOS inhibition, and the enhanced endothelial depressor response suggest that physiological signalling by NO within the kidney is impaired in Brown Norway rats because of irrelevant or inappropriate input of NO by eNOS and iNOS.

  18. NASA's Secured Advanced Federated Environment

    NASA Technical Reports Server (NTRS)

    Chow, Edward; Korsmeyer, David; Paterson, Pat; Liu, Joseph; Stewart, Helen; Burchell, Scott; Chang, Pat; Spence, Matt Chew; Viernes, Conan; Goforth, Andy; Billik, Shoshana; Wheeller, Bob

    2003-01-01

    In 1999, a NASA-wide team initially set out to create a collaborative environment to enable NASA's scientists and engineers to share information and tools across NASA locations and with world-wide partners. This paper describes the team's development process and solutions in resolving conflicting security issues of building a complex intra/inter-enterprise collaborative system. Based on the federated, hierarchical, compartmentalized principles, the Secured Advanced Federated Environment (SAFE) developed by the team is becoming a foundational element for building a collaborative infrastructure for NASA. This paper also introduces the concept of a Micro Security Domain which can achieve the balance between the need to collaborate and the need to enforce enterprise and local security rules. SAFE'S federated security concepts enables networks to be formed around the functional/security requirements. With the SAFE technologies and approaches, security will not be an afterthought of the enterprise network design.

  19. Reluctant partners: Implementing federal policy

    SciTech Connect

    Stoker, R.P.

    1991-01-01

    Reluctant Partners examines how the federal government can secure the cooperation it needs to effect national policy goals whtn the implementation process itself empowers potential adversaries. The current battle over how and where to permanently store the nation's high-level nuclear waste poses one of the greatest challenges to federalism since the Civil War. Authority has been legislatively diffused among the federal government, the states, the counties, and certain affected Indian tribes. The situation also epitomizes the conflict that arises when Congress delegates final decisionmaking authority to the bureaucracy. The book contributes to the body of implementation literature by moving past organizational theory to consider issues of governance and leadership. However, it will disappoint the empiricist who sees an opportunity for the application of a theory go by the boards.

  20. Federal budget process: An overview

    NASA Astrophysics Data System (ADS)

    Frizzell, Virgil A., Jr.

    Much geophysical research funding originates from the federal government, and many who obtain federal funding consider the executive branch to be its source. In fact, the federal budget results from a complex ballet between the executive and legislative branches. Because it is both little understood and essential to our work, this report will review the fundamentals of the three-year budgetary process.The Constitution assigns the power of the purse to the Congress. Before the 1920s, executive branch agencies and departments submitted their own separate budgets to Congress, and deliberate planning and priority setting was minimal. In 1921 Congress empowered the president to submit an executive branch budget reflecting his priorities for the next fiscal year. Following this protocol, former President Reagan submitted his budget for Fiscal Year 1990 in January, and President Bush outlined his FY'90 priorities in February.

  1. Federal Personnel: Federal/Private Sector Pay Comparisons

    DTIC Science & Technology

    1994-12-01

    Federal Employees Covered by Social Security, December 1984. ^This finding is based on a comparison of employer cost associated with the various...and gender. Specifically, ’For a further discussion, see Robert Willis, "Wage Determinante : A Survey and ReinterpreteÜori of Human Capital Earnings

  2. Exploring Elementary Science Methods Course Contexts to Improve Preservice Teachers' NOS of Science Conceptions and Understandings of NOS Teaching Strategies

    ERIC Educational Resources Information Center

    Akerson, Valarie L.; Weiland, Ingrid; Rogers, Meredith Park; Pongsanon, Khemmawaddee; Bilican, Kader

    2014-01-01

    We explored adaptations to an elementary science methods course to determine how varied contexts could improve elementary preservice teachers' conceptions of NOS as well as their ideas for teaching NOS to elementary students. The contexts were (a) NOS Theme in which the course focused on the teaching of science through the consistent teaching…

  3. Veterans Benefits: Federal Employment Assistance

    DTIC Science & Technology

    2007-05-25

    and the VWIP program, the VETS office in DOL also: CRS-4 7 Local one - stop service centers can be found online at [http://www.servicelocator.org/]. 8...USERRA, P.L. 103-353). All VETS activities are required partners in the One - Stop Career Center system established by WIA.7 Federal Employment...required to post job openings through state job services or one stop offices, and may post job openings on the federal online service (America’s Job Bank

  4. 40 CFR 1508.12 - Federal agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Federal agency. 1508.12 Section 1508.12 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.12 Federal agency. Federal agency means all agencies of the Federal Government. It does not mean the Congress,...

  5. 1 CFR 11.2 - Federal Register.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Federal Register. 11.2 Section 11.2 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.2 Federal Register. (a) The subscription price for the paper edition of...

  6. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Federal Register. 12.1 Section 12.1 General... PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the daily Federal Register in paper or microfiche form shall be made available to the following without charge:...

  7. 1 CFR 11.2 - Federal Register.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Federal Register. 11.2 Section 11.2 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.2 Federal Register. (a) The subscription price for the paper edition of...

  8. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Federal Register. 12.1 Section 12.1 General... PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the daily Federal Register in paper or microfiche form shall be made available to the following without charge:...

  9. 1 CFR 11.2 - Federal Register.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Federal Register. 11.2 Section 11.2 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.2 Federal Register. (a) The subscription price for the paper edition of...

  10. 1 CFR 11.2 - Federal Register.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Federal Register. 11.2 Section 11.2 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.2 Federal Register. (a) The subscription price for the paper edition of...

  11. 1 CFR 11.2 - Federal Register.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Federal Register. 11.2 Section 11.2 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.2 Federal Register. (a) The subscription price for the paper edition of...

  12. 77 FR 59026 - Federal Salary Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-25

    ... MANAGEMENT Federal Salary Council AGENCY: Office of Personnel Management. ACTION: Notice of meeting. SUMMARY: The Federal Salary Council will meet on October 19, 2012, at the time and location shown below. The... locality pay areas, the coverage of salary surveys, the process of comparing Federal and non-Federal...

  13. 78 FR 65717 - Federal Salary Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... MANAGEMENT Federal Salary Council AGENCY: Office of Personnel Management. ACTION: Notice of meeting. SUMMARY: The Federal Salary Council meeting originally scheduled for November 5, 2013 (FR Vol. 78, No. 192... locality pay areas, the coverage of salary surveys, the process of comparing Federal and non-Federal...

  14. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No....

  15. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false 2 Federal Special Federal Aviation Regulation No. 100 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Federal Aviation Regulation No. 100-2 Editorial Note: For the text of SFAR No. 100-2, see part 61 of...

  16. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Federal Aviation Regulation No. 50-2 Editorial Note: For the text of SFAR No. 50-2, see part 91 of...

  17. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Federal Aviation Regulation No. 50-2 Editorial Note: For the text of SFAR No. 50-2, see part 91 of...

  18. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false 2 Federal Special Federal Aviation Regulation No. 100 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Special Federal Aviation Regulation...

  19. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Federal Aviation Regulation No. 50-2 Editorial Note: For the text of SFAR No. 50-2, see part 91 of...

  20. 14 CFR Special Federal Aviation... - 1

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false 1 Federal Special Federal Aviation Regulation No. 100 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS Special Federal Aviation Regulation...

  1. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false 2 Federal Special Federal Aviation Regulation No. 100 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS Special Federal Aviation Regulation...

  2. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false 2 Federal Special Federal Aviation Regulation No. 100 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS Special Federal Aviation Regulation...

  3. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No....

  4. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false 2 Federal Special Federal Aviation Regulation No. 100 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Special Federal Aviation Regulation...

  5. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false 2 Federal Special Federal Aviation Regulation No. 100 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Federal Aviation Regulation No. 100-2 Editorial Note: For the text of SFAR No. 100-2, see part 61 of...

  6. 14 CFR Special Federal Aviation... - 1

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false 1 Federal Special Federal Aviation Regulation No. 100 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Special Federal Aviation Regulation...

  7. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No....

  8. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Federal Aviation Regulation No. 50-2 Editorial Note: For the text of SFAR No. 50-2, see part 91 of...

  9. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No....

  10. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Federal Aviation Regulation No. 50-2 Editorial Note: For the text of SFAR No. 50-2, see part 91 of...

  11. 14 CFR Special Federal Aviation... - 2

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No....

  12. 23 CFR 751.17 - Federal participation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Federal participation. 751.17 Section 751.17 Highways... AND ACQUISITION § 751.17 Federal participation. (a) Federal funds may participate in 75 percent of the... Interstate and primary highways, the FHWA may approve Federal participation in the costs of applying...

  13. 23 CFR 772.13 - Federal participation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Federal participation. 772.13 Section 772.13 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT PROCEDURES FOR ABATEMENT OF HIGHWAY TRAFFIC NOISE AND CONSTRUCTION NOISE § 772.13 Federal participation. (a) Federal...

  14. 23 CFR 772.13 - Federal participation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Federal participation. 772.13 Section 772.13 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT PROCEDURES FOR ABATEMENT OF HIGHWAY TRAFFIC NOISE AND CONSTRUCTION NOISE § 772.13 Federal participation. (a) Federal...

  15. 23 CFR 751.17 - Federal participation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Federal participation. 751.17 Section 751.17 Highways... AND ACQUISITION § 751.17 Federal participation. (a) Federal funds may participate in 75 percent of the... Interstate and primary highways, the FHWA may approve Federal participation in the costs of applying...

  16. 23 CFR 752.11 - Federal participation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Federal participation. 752.11 Section 752.11 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT LANDSCAPE AND ROADSIDE DEVELOPMENT § 752.11 Federal participation. (a) Federal-aid highway funds, but generally...

  17. 49 CFR 1325.3 - Federal office.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Federal office. 1325.3 Section 1325.3... FEDERAL OFFICE OR THEIR REPRESENTATIVES § 1325.3 Federal office. For the purposes of this section, Federal office means the office of President or Vice President of the United States; or of Senator...

  18. 23 CFR 751.17 - Federal participation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Federal participation. 751.17 Section 751.17 Highways... AND ACQUISITION § 751.17 Federal participation. (a) Federal funds may participate in 75 percent of the... Interstate and primary highways, the FHWA may approve Federal participation in the costs of applying...

  19. 23 CFR 752.11 - Federal participation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Federal participation. 752.11 Section 752.11 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT LANDSCAPE AND ROADSIDE DEVELOPMENT § 752.11 Federal participation. (a) Federal-aid highway funds, but generally...

  20. 23 CFR 751.17 - Federal participation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Federal participation. 751.17 Section 751.17 Highways... AND ACQUISITION § 751.17 Federal participation. (a) Federal funds may participate in 75 percent of the... Interstate and primary highways, the FHWA may approve Federal participation in the costs of applying...

  1. 23 CFR 752.11 - Federal participation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Federal participation. 752.11 Section 752.11 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT LANDSCAPE AND ROADSIDE DEVELOPMENT § 752.11 Federal participation. (a) Federal-aid highway funds, but generally...

  2. 23 CFR 752.11 - Federal participation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Federal participation. 752.11 Section 752.11 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT LANDSCAPE AND ROADSIDE DEVELOPMENT § 752.11 Federal participation. (a) Federal-aid highway funds, but generally...

  3. Federal Involvement in Day Care.

    ERIC Educational Resources Information Center

    Malone, Margaret

    Because of the expanding need for child care for preschool children, and for older children in after-school hours, there is greater interest in programs for day care, and increasing acceptance of the concept of publicly-financed day care. This paper describes the market for day care, the federal programs which exist and the standards which have…

  4. Federal Financing of Indian Education.

    ERIC Educational Resources Information Center

    Loon, Eric Van

    Since over 200 million Federal dollars are disbursed annually for American Indian education under Bureau of Indian Affairs (BIA), Elementary Secondary Education Act Title I, Indian Education Act Title IV, and Johnson O'Malley programs, it is difficult to understand the dismal state of Indian education. However, factors contributing to abuse of…

  5. Federal Supervisors and Poor Performers

    DTIC Science & Technology

    1999-07-01

    This report looks at the prevalence of poor performance in the Federal workplace from the perspective of employees and supervisors. The report also...examines what supervisors do about poor performers, the effects of supervisors’ actions, and the factors that influence supervisors’ decisions about how they will handle inadequate performance.

  6. The Universities and Federal Regulation.

    ERIC Educational Resources Information Center

    Crowley, John C.

    The impact of increasing federal regulation on American universities is discussed based on an informal survey of senior academic and administrative officials in 13 public and private universities. As government regulation is becoming more intensive and compliance more resource- and time-consuming, government is perceived as having little…

  7. Teacher Leadership: Federal Policy Recommendations

    ERIC Educational Resources Information Center

    Gran, Jackie; Young, Margaret; Broin, Alexandra

    2015-01-01

    This policy brief was developed specifically for federal policymakers, and builds upon the policy recommendations included in "Leading from Every Seat: Empowering Principals to Cultivate Teacher Leadership for School Improvement." The recommendations in this report include the following: (1) Uncover New Leadership Ideas and Seed…

  8. Guide to Federal Consumer Services.

    ERIC Educational Resources Information Center

    Office of Consumer Affairs, Washington, DC.

    This publication lists the consumer services of every Federal agency or bureau that is either directly of indirectly concerned with consumer issues. Services covered include agricultural research service, consumer and marketing service, extension service, food and nutrition service, rural development and conservation, farm credit, environmental…

  9. Federalization of Education in Chihuahua

    ERIC Educational Resources Information Center

    Marak, Andrae M.

    2005-01-01

    This article examines the politics behind the initial centralization of primary education in Chihuahua, Mexico during the 1920s and 1930s. The article argues that the centralization of primary education was one of many tools used by the federal government to consolidate its power in the wake of the Mexican Revolution (1910-1917) and create a…

  10. Federal Advisory Committees: An Overview

    DTIC Science & Technology

    2009-04-16

    initiating a tradition of presidential use of outside expertise when, in 1794 , he appointed an ad hoc group of commissioners to investigate the Whiskey ... Rebellion .7 Since 1842, Congress has legislated control over federal advisory bodies — mostly by limiting funding and committee member pay. In 1842...reports aggregated advisory body information to Congress annually.12 7 " Whiskey Insurrection in

  11. The Federal Government and Nutrition.

    ERIC Educational Resources Information Center

    Powers, Margaret A.

    1980-01-01

    Both the Department of Agriculture and the Department of Health and Human Services conduct research related to food and human nutrition. Several federal programs supporting nutrition research and education are reviewed. Footnotes provide addresses and ways to obtain more detailed information about nutrition related programs. (JN)

  12. Federal Depository Libraries and Librarianship.

    ERIC Educational Resources Information Center

    Illinois Libraries, 1986

    1986-01-01

    Reports results of 1985 survey of federal depository libraries in Illinois, including the arrangement of collections and bibliographic access, acquisitions and weeding, services and equipment, library and librarian cooperation, documents staff, State Plan and State Plan Coordinating Council, online systems and access to government documents, and…

  13. Update: Federal Republic of Germany.

    ERIC Educational Resources Information Center

    Loewenthal, Nessa P.

    The Federal Republic of Germany is widely respected for its highly developed economy, rich cultural life, and significant contributions to science, mathematics, and the arts. Designed for families or individuals planning to move to or live in Germany for extended periods of time, this book provides guidance in such practical matters as entry…

  14. 78 FR 32622 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ...Notice is hereby given that the National Ocean Service Marine Forensic Lab (NOS Lab) [Responsible Party: M. Katherine Moore], 219 Fort Johnson Road, Charleston, SC 29412 (File No. 17557), and the NOAA Fisheries Northeast Region, Protected Resources Division [Responsible Party: Mary Colligan], 1 Blackburn Drive, Gloucester, MA 01930 (File No. 17273), have applied in due form for permits to take......

  15. 78 FR 50395 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ...Notice is hereby given that the National Ocean Service Marine Forensic Lab (NOS Lab) [Responsible Party: M. Katherine Moore], 219 Fort Johnson Road, Charleston, SC 29412 (File No. 17557), and the NOAA Fisheries Northeast Region, Protected Resources Division [Responsible Party: Mary Colligan], 1 Blackburn Drive, Gloucester, MA 01930 (File No. 17273), have been issued permits to take marine......

  16. First light of the NIRISS Optical Simulator (NOS)

    NASA Astrophysics Data System (ADS)

    St-Antoine, Jonathan; Albert, Loïc.; Doyon, René; Vallée, Philippe; Artigau, Étienne; Hernandez, Olivier; Thibault, Simon; Brousseau, Denis

    2016-07-01

    The Near Infrared Imager and Slitless Spectrograph (NIRISS) Optical Simulator (NOS) is a laboratory simulation of the single-object slitless spectroscopy and aperture masking interferometry modes of the NIRISS instrument onboard the James Webb Space Telescope (JWST). A transiting exoplanet can be simulated by periodically eclipsing a small portion (1% - 10ppm) of a super continuum laser source (0.4 μm - 2.4 μm) with a dichloromethane filled cell. Dichloromethane exhibits multiple absorption features in the near infrared domain hence the net effect is analogous to the atmospheric absorption features of an exoplanet transiting in front of its host star. The NOS uses an HAWAII-2RG and an ASIC controller cooled to cryogenic temperatures. A separate photometric beacon provides a flux reference to monitor laser variations. The telescope jitter can be simulated using a high-resolution motorized pinhole placed along the optical path. Laboratory transiting spectroscopy data produced by the NOS will be used to refine analysis methods, characterize the noise due to the jitter, characterize the noise floor and to develop better observation strategies. We report in this paper the first exoplanet transit event simulated by the NOS. The performance is currently limited by relatively high thermal background in the system and high frequency temporal variations of the continuum source.

  17. Las Rocas Nos Cuentan (Rocks Tell Their Stories)

    ERIC Educational Resources Information Center

    Llerandi-Roman, Pablo A.

    2012-01-01

    Many Earth science lessons today still focus on memorizing the names of rocks and minerals. This led the author to develop a lesson that reveals the fascinating stories told by rocks through the study of their physical properties. He first designed the lesson for Puerto Rican teachers, hence its Spanish title: "Las Rocas Nos Cuentan Su Historia."…

  18. 4. Southwest fronts, dock nos. 491 and 492. Southeast end, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Southwest fronts, dock nos. 491 and 492. Southeast end, dock no. 492. View to north. - Offutt Air Force Base, Looking Glass Airborne Command Post, Nose Docks, On either side of Hangar Access Apron at Northwest end of Project Looking Glass Historic District, Bellevue, Sarpy County, NE

  19. Airfield setting of Facility Nos. 175 and 176, taken from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Airfield setting of Facility Nos. 175 and 176, taken from north end of Ford Island Runway, with landplane hangars on the right - U.S. Naval Base, Pearl Harbor, Landplane Hangar Type, Wasp Boulevard and Gambier Bay Street, Pearl City, Honolulu County, HI

  20. Building Nos. 92, 381, and 392, view into common courtyard ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building Nos. 92, 381, and 392, view into common courtyard between 92 (right), 391 (center deep), and 392 (left), view facing west-northwest - U.S. Naval Base, Pearl Harbor, Marine Railway No. 1 Accessories House & Apprentice Welding School, Additions, Intersection of Avenue B & Sixth Street, Pearl City, Honolulu County, HI

  1. 50. INTERIOR OF BRIDGE SUSPENSION STRUCTURE ABOVE BRIDGE NOS. 10 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    50. INTERIOR OF BRIDGE SUSPENSION STRUCTURE ABOVE BRIDGE NOS. 10 AND 9 SHOWING CABLE COUNTERWEIGHT SYSTEM AND SCREW-TYPE VERTICAL ADJUSTMENT MACHINERY (LIFTING SCREWS). LOOKING NORTH. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

  2. 7. VIEW OF NORTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW OF NORTH SECTION OF STRUCTURE SHOWING BRIDGE NOS. 10 AND 9 FROM BRIDGE NO. 11 APRON. LOOKING NORTH. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

  3. AIRMEN'S BARRACKS (FACILITY Nos. 422, 442, AND 420) IN MIDDLE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AIRMEN'S BARRACKS (FACILITY Nos. 422, 442, AND 420) IN MIDDLE DISTANCE, ALSO SHOWING ESCOLTA AVENUE AT RIGHT, LOOKING SOUTHEAST FROM RESERVOIR HILL. (Part 2 of a 3 view panorama; see also CA-2398-4 and CA-2398-6.) - Hamilton Field, East of Nave Drive, Novato, Marin County, CA

  4. 16. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. III ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. III and IV (Frederic R. Harris, Inc., January 10, 1941). In Files of Cushman & Wakefield, Building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  5. 15. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. I ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. I and II (Frederic R. Harris, Inc., January 10, 1941). In Files of Cushman & Wakefield, Building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  6. Langley VEDIT for NOS/VE usage manual

    NASA Technical Reports Server (NTRS)

    Heaney, Margaret A.

    1987-01-01

    The use of the VEDIT editor on the CDC Network Operating System/Virtual Environment (NOS/VE) is discussed. The VEDIT, a utility, allows a user to edit files line by line (line mode). How to access and the use of VEDIT are explained. The parameters and the format of the individual commands are defined. Examples are included.

  7. Overall contextual view of Building Nos. 92, 391, and 392, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Overall contextual view of Building Nos. 92, 391, and 392, taken from pier side, crane rails along bravo piers in foreground, palm tree and street light at right center, view facing east-northeast - U.S. Naval Base, Pearl Harbor, Marine Railway No. 1 Accessories House & Apprentice Welding School, Additions, Intersection of Avenue B & Sixth Street, Pearl City, Honolulu County, HI

  8. 77 FR 61051 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ... Eliseos No. 403 Interior 202, Colonia Polanco, Delegacion Miguel Hidalgo, Distrito Federal Codigo Postal 11550, Mexico; Calle Moliere No. 66, Colonia Palmas Polanco, Delegacion Miguel Hidalgo, Distrito Federal... Venustiano Carranza, Distrito Federal Codigo Postal 15230, Mexico; Calle Moliere No. 227, Colonia...

  9. Green Roofs: Federal Energy Management Program (FEMP) Federal Technology Alert

    SciTech Connect

    Scholz-Barth, K.; Tanner, S.

    2004-09-01

    In a ''green roof,'' a layer of vegetation (e.g., a roof garden) covers the surface of a roof to provide shade, cooler indoor and outdoor temperatures, and effective storm-water management to reduce runoff. The main components are waterproofing, soil, and plants. There are two basic kinds: intensive and extensive. An intensive green roof often features large shrubs and trees, and it can be expensive to install and maintain. An extensive green roof features shallow soil and low-growing, horizontally spreading plants that can thrive in the alpine conditions of many rooftops. These plants do not require a lot of water or soil, and they can tolerate a significant amount of exposure to the sun and wind. This Federal Technology Alert focuses on the benefits, design, and implementation of extensive green roofs and includes criteria for their use on federal facilities.

  10. High Level Architecture (HLA) federation with Umbra and OPNET federates.

    SciTech Connect

    Oppel, Fred John III; Hart, Brian; Van Leeuwen, Brian P.

    2004-03-01

    Network-centric systems that depend on mobile wireless ad hoc networks for their information exchange require detailed analysis to support their development. In many cases, this critical analysis is best provided with high-fidelity system simulations that include the effects of network architectures and protocols. In this research, we developed a high-fidelity system simulation capability using an HLA federation. The HLA federation, consisting of the Umbra system simulator and OPNET Modeler network simulator, provides a means for the system simulator to both affect, and be affected by, events in the network simulator. Advances are also made in increasing the fidelity of the wireless communication channel and reducing simulation run-time with a dead reckoning capability. A simulation experiment is included to demonstrate the developed modeling and simulation capability.

  11. Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS

    PubMed Central

    Morsy, Mohamed A.; Ibrahim, Salwa A.; Amin, Entesar F.; Kamel, Maha Y.; Rifaai, Rehab A.; Hassan, Magdy K.

    2014-01-01

    Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity. Sildenafil, a selective phosphodiesterase-5 inhibitor, was reported to prevent or decrease tissue injury. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicin-induced nephrotoxicity in rats. Male Wistar rats were injected with gentamicin (100 mg/kg/day, i.p.) for 6 days with and without sildenafil. Sildenafil administration resulted in nephroprotective effect in gentamicin-intoxicated rats as it significantly decreased serum creatinine and urea, urinary albumin, and renal malondialdehyde and nitrite/nitrate levels, with a concomitant increase in renal catalase and superoxide dismutase activities compared to gentamicin-treated rats. Moreover, immunohistochemical examination revealed that sildenafil treatment markedly reduced inducible nitric oxide synthase (iNOS) expression, while expression of endothelial nitric oxide synthase (eNOS) was markedly enhanced. The protective effects of sildenafil were verified histopathologically. In conclusion, sildenafil protects rats against gentamicin-induced nephrotoxicity possibly, in part, through its antioxidant activity, inhibition of iNOS expression, and induction of eNOS production. PMID:25120567

  12. 49 CFR 613.300 - Coordination of Federal and federally assisted programs and projects.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Coordination of Federal and federally assisted programs and projects. 613.300 Section 613.300 Transportation Other Regulations Relating to Transportation... Coordination of Federal and Federally Assisted Programs and Projects § 613.300 Coordination of Federal...

  13. 75 FR 8278 - Participation by Federal Candidates and Officeholders at Non-Federal Fundraising Events

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... 11 CFR Part 300 Participation by Federal Candidates and Officeholders at Non- Federal Fundraising... participation by Federal candidates and officeholders in non-Federal fundraising events, with a public hearing... rulemaking (``NPRM'') relating to participation by Federal candidates and officeholders in...

  14. The FY2011 Federal Budget

    DTIC Science & Technology

    2010-08-04

    Finance August 4, 2010 Congressional Research Service 7-5700 www.crs.gov R41097 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public...Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 The FY2011 Federal Budget Congressional Research Service Summary While considering the...current form may pass substantial economic burdens to future generations. The Obama Administration released its FY2011 budget on February 1, 2010. The

  15. The FY2011 Federal Budget

    DTIC Science & Technology

    2010-03-09

    Finance March 9, 2010 Congressional Research Service 7-5700 www.crs.gov R41097 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public...Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 The FY2011 Federal Budget Congressional Research Service Summary While considering the...current form may pass substantial economic burdens to future generations. The Obama Administration released its FY2011 budget on February 1, 2010

  16. Veterans Benefits: Federal Employment Assistance

    DTIC Science & Technology

    2010-04-09

    Services Employment and Reemployment Rights Act of 1994 (USERRA, P.L. 103-353). All VETS activities are required partners in the One - Stop Career Center...please see CRS Report RL34024, Veterans and Homelessness, by Libby Perl. 8 Local one - stop service centers can be found online at http...through state job services or one stop offices, and may post job openings on the federal online service (America’s Job Bank).15 Veterans Hiring

  17. Veterans Benefits: Federal Employment Assistance

    DTIC Science & Technology

    2008-01-14

    enhance workforce investment activities CRS-4 7 Local one - stop service centers can be found online at [http://www.servicelocator.org/]. 8 For federal...Employment and Reemployment Rights Act of 1994 (USERRA, P.L. 103-353). All VETS activities are required partners in the One - Stop Career Center system...veterans. Contractors and subcontractors are required to post job openings through state job services or one stop offices, and may post job openings

  18. Findability of Federal Research Data

    NASA Astrophysics Data System (ADS)

    Hourcle, J. A.

    2013-12-01

    Findability of Federal Research Data Although many of the federal agencies have been providing access to scientific research data for years if not decades, the findability of the data has been quite lacking. Many discipline-wide efforts have been made in the big science communities, such as PDS for planetary science and the VOs in night time astronomy and heliophysics, but there is a lack of single entry point for someone looking for data. The science.gov website contains links to many of these big-science search systems, but doesn't differentiate between links to science quality data and websites or browse products, making it more difficult to search specifically for data. The data.gov website is a useful repository for PIs of small science data to stash their data, particularly as it allows for interested parties to interact with tabular data. Unfortunately, as each group thinks of their data differently, much of what's now in the system is a mess; collections of data being tracked as individual records with no relationships between them. Big science projects also get tracked as single records, potentially with only a single record for missions with multiple instruments and significantly different data series. We present recommendations on how to improve the findability of federal research data on data.gov, based on years of working on the Virtual Solar Observatory and withing the science informatics community.

  19. Association of NOS2 and NOS3 gene polymorphisms with susceptibility to type 2 diabetes mellitus and diabetic nephropathy in the Chinese Han population.

    PubMed

    Chen, Feng; Li, Yu-Mei; Yang, Lin-Qing; Zhong, Cai-Gao; Zhuang, Zhi-Xiong

    2016-07-01

    Inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3) gene play important roles in the susceptibility to type 2 diabetes mellitus (T2DM). The present study aims to detect the potential association of NOS2 and NOS3 gene polymorphisms with the susceptibility toT2DM and diabetic nephropathy (DN) in the Chinese Han population. Four hundred and ninety T2DM patients and 485 healthy controls were enrolled in this case-control study. The genotypes of NOS2 and NOS3 gene polymorphisms were analyzed by the polymerase chain reaction (PCR)-ligase detection reaction (LDR) method. Our data demonstrated that the NOS2 rs2779248 and NOS2 rs1137933 genetic polymorphisms were significantly associated with the increased susceptibility to T2DM in the heterozygote comparison, dominant model, and allele contrast; and NOS3 rs3918188 genetic polymorphism was significantly associated with the increased susceptibility to T2DM in the homozygote comparison and recessive model. The allele-C and genotype-TC of NOS2 rs2779248, allele-A and genotype-GA of NOS2 rs1137933 and genotype-AA of NOS3 rs3918188 genetic polymorphisms might be the risk factors for increasing the susceptibility to T2DM. And a significant haplotype effect of NOS2 rs10459953/C- rs1137933/G- rs2779248/T was found between T2DM cases and controls. Moreover, NOS3 rs1800783 polymorphism was significantly associated with the increased susceptibility to DN in the heterozygote comparison, recessive model and allele contrast. At last, a positive correlation of family history of diabetes with NOS3 rs11771443 polymorphism was found in DN. These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and NOS3 rs3918188 genetic polymorphisms are potentially related to the susceptibility to T2DM, and the rs1800783 polymorphism might be considered as genetic risk factors for diabetic nephropathy, and family history of diabetes was closely associated with rs11771443 polymorphism in DN, and the

  20. Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms.

    PubMed

    Oliveira-Paula, Gustavo H; Lacchini, Riccardo; Tanus-Santos, Jose E

    2016-01-10

    Nitric oxide (NO) is an important vasodilator with a well-established role in cardiovascular homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and inducible nitric oxide synthases (NOS1,NOS3 and NOS2 respectively), NOS3 is the most important isoform for NO formation in the cardiovascular system. NOS3 is a dimeric enzyme whose expression and activity are regulated at transcriptional, posttranscriptional,and posttranslational levels. The NOS3 gene, which encodes NOS3, exhibits a number of polymorphic sites including single nucleotide polymorphisms (SNPs), variable number of tandem repeats (VNTRs), microsatellites, and insertions/deletions. Some NOS3 polymorphisms show functional effects on NOS3 expression or activity, thereby affecting NO formation. Interestingly, many studies have evaluated the effects of functional NOS3 polymorphisms on disease susceptibility and drug responses. Moreover, some studies have investigated how NOS3 haplotypes may impact endogenous NO formation and disease susceptibility. In this article,we carried out a comprehensive review to provide a basic understanding of biochemical mechanisms involved in NOS3 regulation and how genetic variations in NOS3 may translate into relevant clinical and pharmacogenetic implications.

  1. 78 FR 67200 - Federal-State Unemployment Compensation Program: Certifications for 2013 Under the Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Employment and Training Administration Federal-State Unemployment Compensation Program: Certifications for 2013 Under the Federal Unemployment Tax Act AGENCY: Employment and Training Administration. ACTION: Notice. SUMMARY: The Secretary of Labor signed the annual certifications under the Federal...

  2. 76 FR 54772 - Federal Management Regulation; FMR Bulletin PBS-2011-B2; Redesignations of Federal Buildings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... ADMINISTRATION Federal Management Regulation; FMR Bulletin PBS-2011-B2; Redesignations of Federal Buildings AGENCY: Public Buildings Service (P), General Services Administration. ACTION: Notice of a bulletin. SUMMARY: The attached bulletin announces the designation and redesignation of two Federal...

  3. 48 CFR Appendix - Federal Acquisition Regulation (FAR) Index

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Federal Acquisition Regulation (FAR) Index Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT... (IFMS) Contract clause. FAR Index Federal Acquisition Regulation (FAR) Index Editorial Note:...

  4. 48 CFR Appendix - Federal Acquisition Regulation (FAR) Index

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Federal Acquisition Regulation (FAR) Index Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT... (IFMS) Contract clause. FAR Index Federal Acquisition Regulation (FAR) Index Editorial Note:...

  5. 78 FR 33092 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-03

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications..., this notice advises interested persons that the Federal Communications Commission's (FCC)...

  6. Federal laboratories for the 21st century

    SciTech Connect

    Gover, J.; Huray, P.G.

    1998-04-01

    Federal laboratories have successfully filled many roles for the public; however, as the 21st Century nears it is time to rethink and reevaluate how Federal laboratories can better support the public and identify new roles for this class of publicly-owned institutions. The productivity of the Federal laboratory system can be increased by making use of public outcome metrics, by benchmarking laboratories, by deploying innovative new governance models, by partnerships of Federal laboratories with universities and companies, and by accelerating the transition of federal laboratories and the agencies that own them into learning organizations. The authors must learn how government-owned laboratories in other countries serve their public. Taiwan`s government laboratory, Industrial Technology Research Institute, has been particularly successful in promoting economic growth. It is time to stop operating Federal laboratories as monopoly institutions; therefore, competition between Federal laboratories must be promoted. Additionally, Federal laboratories capable of addressing emerging 21st century public problems must be identified and given the challenge of serving the public in innovative new ways. Increased investment in case studies of particular programs at Federal laboratories and research on the public utility of a system of Federal laboratories could lead to increased productivity of laboratories. Elimination of risk-averse Federal laboratory and agency bureaucracies would also have dramatic impact on the productivity of the Federal laboratory system. Appropriately used, the US Federal laboratory system offers the US an innovative advantage over other nations.

  7. 41 CFR 101-29.502 - Use of Federal specifications and interim Federal specifications in Federal construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....502 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 29-FEDERAL PRODUCT DESCRIPTIONS 29.5-Use of and... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Use of...

  8. 77 FR 66087 - Federal Perkins Loan Program, Federal Family Education Loan Program, and William D. Ford Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-01

    ...The Secretary amends the Federal Perkins Loan (Perkins Loan) program, Federal Family Education Loan (FFEL) program, and William D. Ford Federal Direct Loan (Direct Loan) program regulations. These final regulations implement a new Income-Contingent Repayment (ICR) plan in the Direct Loan program based on the President's ``Pay As You Earn'' repayment initiative, incorporate recent statutory......

  9. 1. Streetscape of north ends of Detention Wards, Building Nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Streetscape of north ends of Detention Wards, Building Nos. 9946-B (left) and 9945-B (middle). Walled-in courtyard adjoins Building No. 9944-B at extreme right edge. Steam plant is in distance. This photo makes a panorama with photo WA-202-10-2. - Madigan Hospital, Detention Wards, Bounded by Wilson & McKinley Avenues & Garfield & Lincoln Streets, Tacoma, Pierce County, WA

  10. 38. View of DRS 1, 2, and 3 (structure nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. View of DRS 1, 2, and 3 (structure nos. 735, 736, and 737) console fault locator for beam power status, radio frequency (RF) and intermediate frequency (IF) fault conditions, RF switches status and TR status. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  11. 77 FR 28860 - Notice of Proposed Information Collection Requests; Federal Student Aid; Federal Perkins Loan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ... Master Promissory Note SUMMARY: The Federal Perkins Loan Master Promissory Note (MPN) provides the terms... records. Title of Collection: Federal Perkins Loan Program Master Promissory Note. OMB Control...

  12. TNFα antagonization alters NOS2 dependent nasopharyngeal carcinoma tumor growth.

    PubMed

    Bourouba, Mehdi; Zergoun, Ahmed-Amine; Maffei, Joseph S; Chila, Dalia; Djennaoui, Djamel; Asselah, Fatima; Amir-Tidadini, Zine-Charef; Touil-Boukoffa, Chafia; Zaman, Muhammad H

    2015-07-01

    Tumor necrosis factor (TNFα) is a pro-inflammatory cytokine which mediates via nitric oxide (NO) several carcinogenic processes. Increasing evidences suggest that NO promotes inflammation induced growth of nasopharyngeal carcinoma (NPC). In patients, TNFα synthesis associates with poor survival. To explore the effect of the cytokine on NO production and NOS2 dependent NPC growth, NO2(-) (nitrite) producing cells in patients were analyzed in vitro. We observed that patients' monocytes/macrophages (Mo/Ma) and primary tumor biopsies synthesized significant amounts of NO2(-). Interestingly, tumor explants derived NO2(-) levels were more important in elderly patients in comparison with juveniles. Endogenous TNFα neutralization with an anti-TNFα monoclonal antibody (mAb) successfully inhibited NO2(-) synthesis by blood mononuclear cells and tumor explants. Recombinant TNFα (rTNFα) enhanced NO2(-) synthesis and C666-1 NPC cell proliferation. NOS2 selective inhibition (1400W) and TNFα antagonization with an anti-TNFα mAb potently inhibited rTNFα induced C666-1 proliferation and NO2(-) production. Importantly, primary tumors treated with the anti-TNFα mAb also displayed reduced proliferation index (Ki67). Altogether, our results define monocytes/macrophages and the primary tumor as major sources of circulating NO2(-) in NPC patients and support the idea that antibody dependent inhibition of the TNFα/NOS2 pathway may alter NPC tumor growth.

  13. Federal Interagency Committee on Indoor Air Quality

    EPA Pesticide Factsheets

    The Federal Interagency Committee on Indoor Air Quality (CIAQ), which meets three times a year, was established by Congress to coordinate the activities of the Federal Government on issues relating to Indoor Air Quality.

  14. Enforcement and Compliance at Federal Facilities

    EPA Pesticide Factsheets

    Guide for complying with environmental laws and regulations at Federal Facilities This resource updates EPA's The Yellow Book: Guide to Environmental Enforcement and Compliance in Federal Facilities published in 1999.

  15. 77 FR 38342 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Week of June 25, 2012. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville,...

  16. 77 FR 1521 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of January 9, 16, 23, 30, February 6, 13, 2012. PLACE: Commissioners' Conference Room,...

  17. 76 FR 8788 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of February 14, 21, 28, March 7, 14, 21, 2011. PLACE: Commissioners' Conference Room,...

  18. 76 FR 10410 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY: Nuclear Regulatory Commission. DATES: Weeks of February 21, 28, March 7, 14, 21, 28, 2011. PLACE: Commissioners' Conference Room, 11555 Rockville...

  19. 77 FR 61644 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of October 8, 15, 22, 29, November 5, 12, 2012. PLACE: Commissioners' Conference Room,...

  20. 77 FR 5063 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, DATE: Week of January 30, 2012. PLACE: Commissioners' Conference Room, 11555 Rockville Pike,...

  1. 77 FR 59678 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Weeks of October 1, 8, 15, 22, 29, November 5, 2012. PLACE: Commissioners' Conference Room,...

  2. 77 FR 15142 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Week of March 12, 2012. PLACE: Commissioners' Conference Room, 11555 Rockville Pike,...

  3. 75 FR 80083 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Weeks of December 20, 27, 2010, January 3, 10, 17, 24, 2011. PLACE: Commissioners' Conference...

  4. 77 FR 2572 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Weeks of January 16, 23, 30, February 6, 13, 20, 2012. PLACE: Commissioners' Conference Room,...

  5. 76 FR 55718 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding The Meetings: Nuclear Regulatory Commission. DATE: Week of September 5, 2011. PLACE: Commissioners' Conference Room, 11555 Rockville Pike,...

  6. 76 FR 16459 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Week of March 21, 2011. PLACE: Commissioners' Conference Room, 11555 Rockville Pike,...

  7. 76 FR 46329 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of August 1, 8, 15, 22, 29, September 5, 2011. PLACE: Commissioners' Conference Room,...

  8. 75 FR 55832 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission [NRC-2010- 0002]. DATES: Weeks of September 13, 20, 27, October 4, 11, 18, 2010. PLACE:...

  9. 77 FR 17102 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC-2012- 0002]. DATE: Week of March 26, 2012. PLACE: Commissioners' Conference Room, 11555 Rockville...

  10. 75 FR 64367 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, DATE: Weeks of October 18, 25, November 1, 8, 15, 22, 2010. PLACE: Commissioners' Conference Room,...

  11. 77 FR 48564 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of August 13, 20, 27, September 3, 10, 17, 2012. PLACE: Commissioners' Conference Room,...

  12. 75 FR 62894 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. Date: Weeks of October 11, 18, 25, November 1, 8, 15, 2010. Place: Commissioners' Conference Room,...

  13. 75 FR 28303 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC-2010- 0002]. DATE: Week of May 24, 2010. PLACE: Commissioners' Conference Room, 11555 Rockville...

  14. 77 FR 57597 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, DATE: Weeks of September 17, 24, October 1, 8, 15, 22, 2012. PLACE: Commissioners' Conference Room,...

  15. 75 FR 34489 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Week of June 14, 2010. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville,...

  16. 76 FR 52717 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. ] DATE: Weeks of August 22, 29, September 5, 12, 19, 26, 2011. PLACE: Commissioners' Conference...

  17. 76 FR 1653 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Weeks of January 10, 17, 24, 31, February 7, 14, 2011. PLACE: Commissioners' Conference Room,...

  18. 76 FR 62868 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Week of October 10, 2011. PLACE: Commissioners' Conference Room, 11555 Rockville Pike,...

  19. 77 FR 3804 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC-2012- 0002]. DATE: Week of January 30, 2012. PLACE: Commissioners' Conference Room, 11555...

  20. 76 FR 48919 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of August 8, 15, 22, 29, September 5, 12, 2011. PLACE: Commissioners' Conference Room,...

  1. 76 FR 41529 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission [NRC-2011- 0006]. DATE: Week of July 11, 2011. PLACE: Commissioners' Conference Room, 11555 Rockville...

  2. 76 FR 4393 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. Dates: Weeks of January 24, 31, February 7, 14, 21, 28, 2011. Place: Commissioners' Conference Room,...

  3. 77 FR 70488 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission DATES: Weeks of November 26, December 3, 10, 17, 24, 31, 2012 PLACE: Commissioners' Conference Room,...

  4. 76 FR 70779 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY: Agency Holding the Meetings: Nuclear Regulatory Commission. DATES: Weeks of November 14, 21, 28, December 5, 12, 19, 2011. Place: Commissioners'...

  5. 77 FR 67689 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Week of November 5, 2012. PLACE: Commissioners' Conference Room, 11555 Rockville Pike,...

  6. 75 FR 65674 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of October 25; November 1, 8, 15, 22, 29, 2010. PLACE: Commissioners' Conference Room,...

  7. 77 FR 304 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Weeks of January 2, 9, 16, 23, 30, February 6, 2012. PLACE: Commissioners' Conference Room,...

  8. 76 FR 78952 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC-2011- 0006]. DATE: Week of December 19, 2011. PLACE: Commissioners' Conference Room, 11555...

  9. 76 FR 64400 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC-2011- 0006]. DATE: Weeks of October 17, 24, 31, November 7, 14, 21, 2011. PLACE:...

  10. 76 FR 11525 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORTY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Week of February 28, 2011. PLACE: Commissioners' Conference Room, 11555 Rockville Pike,...

  11. 75 FR 67408 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. Date: Weeks of November 1, 8, 15, 22, 29, December 6, 2010. Place: Commissioners' Conference Room,...

  12. 75 FR 68630 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-08

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. Date: Week of November 1, 2010. Place: Commissioners' Conference Room, 11555 Rockville Pike,...

  13. 75 FR 59749 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding The Meetings: Nuclear Regulatory Commission. DATES: Weeks of September 27, October 4, 11, 18, 25, and November 1, 2010. Place: Commissioners'...

  14. 76 FR 24540 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Week of April 25, 2011. PLACE: Commissioners' Conference Room, 11555 Rockville Pike,...

  15. 78 FR 127 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of December 31, 2012, January 7, 14, 21, 28, February 4, 2013. PLACE: Commissioners'...

  16. 77 FR 67838 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of November 12, 19, 26, December 3, 10, 17, 2012. PLACE: Commissioners' Conference Room,...

  17. 76 FR 66095 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC-2011- 0006]. DATE: Weeks of October 24, 31, November 7, 14, 21, 28, 2011. PLACE:...

  18. 76 FR 6837 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-08

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of February 7, 14, 21, 28, March 7, 14, 2011. PLACE: Commissioners' Conference Room,...

  19. Which Efficient Products Must Federal Agencies Buy

    SciTech Connect

    2010-08-24

    Fact sheet prepared by the U.S. Department of Energy (DOE) Federal Energy Management Program (FEMP) to help Federal agencies comply with FEMP Designated, Low Standby Power, ENERGY STAR Qualified, and Water Sense Labeled product purchasing requirements.

  20. California OCS Delegation Agreements Federal Register Notices

    EPA Pesticide Factsheets

    These federal register notices notify to the public that EPA has delegated authority to the agencies in the Federal Register Notices for sources within the 25 nautical miles of California's seaward boundary.

  1. 78 FR 13395 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ... Federal Aviation Administration Notice of Availability of Draft Alaska National Interest Lands Conservation Act (ANILCA) Section 810 Subsistence Evaluation. AGENCY: Federal Aviation Administration (FAA... Aviation Administration, Airports Division, 222 West 7th Avenue, Box 14, Anchorage, AK 99513. 5....

  2. Federal Funding Accountability and Transparency Act

    EPA Pesticide Factsheets

    Public Law 109-282, the Federal Funding Accountability and Transparency Act of 2006 as amended (FFATA), requires disclosure of all entities and organizations receiving Federal funds through a single publicly accessible website.

  3. Federal Agency Hazardous Waste Compliance Docket

    EPA Pesticide Factsheets

    The Federal Agency Hazardous Waste Compliance Docket contains information reported to EPA by federal facilities that manage hazardous waste or from which hazardous substances, pollutants, or contaminants have been - or may be - released.

  4. Characteristics and Pay of Federal Civilian Employees

    DTIC Science & Technology

    2007-03-01

    Law Enforcement Officers (August 2005), Comparing the Pay of Federal and Nonprofit Executives: An Update (July 2003), Measuring Differences Between...Federal and Private Pay (November 2002), and Changes in Federal Civilian Employment: An Update (May 2001).In this paper, three general areas are...implement the basic civil service principle of equal pay for substantially equal work by assigning federal jobs to specific grades and steps on the

  5. The Economics of the Federal Budget Deficit

    DTIC Science & Technology

    2007-01-24

    Order Code RL31235 The Economics of the Federal Budget Deficit Updated January 24, 2007 Brian W. Cashell Specialist in Quantitative Economics...number. 1. REPORT DATE 24 JAN 2007 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE The Economics of the Federal Budget Deficit ...Prescribed by ANSI Std Z39-18 The Economics of the Federal Budget Deficit Summary The Congressional Budget Office (CBO) estimates that the federal

  6. High Rates of Psychiatric Co-Morbidity in PDD-NOS

    ERIC Educational Resources Information Center

    de Bruin, Esther I.; Ferdinand, Robert F.; Meester, Sjifra; de Nijs, Pieter F. A.; Verheij, Fop

    2007-01-01

    Rates of co-morbid psychiatric conditions in children with Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) are hardly available, although these conditions are often considered as more responsive to treatment than the core symptoms of PDD-NOS. Ninety-four children with PDD-NOS, aged 6-12 years were included. The DISC-IV-P was…

  7. Posttranscriptional regulation of human iNOS by the NO/cGMP pathway.

    PubMed

    Pérez-Sala, D; Cernuda-Morollón, E; Díaz-Cazorla, M; Rodríguez-Pascual, F; Lamas, S

    2001-03-01

    Nitric oxide (NO) and cGMP may exert positive or negative effects on inducible NO synthase (iNOS) expression. We have explored the influence of the NO/cGMP pathway on iNOS levels in human mesangial cells. Inhibition of NOS activity during an 8-h stimulation with IL-1beta plus tumor necrosis factor (TNF)-alpha reduced iNOS levels, while NO donors amplified iNOS induction threefold. However, time-course studies revealed a subsequent inhibitory effect of NO donors on iNOS protein and mRNA levels. This suggests that NO may contribute both to iNOS induction and downregulation. Soluble guanylyl cyclase (sGC) activation may be involved in these effects. Inhibition of sGC attenuated IL-1beta/TNF-alpha-elicited iNOS induction and reduced NO-driven amplification. Interestingly, cGMP analogs also modulated iNOS protein and mRNA levels in a biphasic manner. Inhibition of transcription unveiled a negative posttranscriptional modulation of the iNOS transcript by NO and cGMP at late times of induction. Supplementation with 8-bromo-cGMP (8-BrcGMP) reduced iNOS mRNA stability by 50%. These observations evidence a complex feedback regulation of iNOS expression, in which posttranscriptional mechanisms may play an important role.

  8. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  9. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  10. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  11. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  12. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  13. Exercise does not activate the β3 adrenergic receptor-eNOS pathway, but reduces inducible NOS expression to protect the heart of obese diabetic mice.

    PubMed

    Kleindienst, Adrien; Battault, Sylvain; Belaidi, Elise; Tanguy, Stephane; Rosselin, Marie; Boulghobra, Doria; Meyer, Gregory; Gayrard, Sandrine; Walther, Guillaume; Geny, Bernard; Durand, Gregory; Cazorla, Olivier; Reboul, Cyril

    2016-07-01

    Obesity and diabetes are associated with higher cardiac vulnerability to ischemia-reperfusion (IR). The cardioprotective effect of regular exercise has been attributed to β3-adrenergic receptor (β3AR) stimulation and increased endothelial nitric oxide synthase (eNOS) activation. Here, we evaluated the role of the β3AR-eNOS pathway and NOS isoforms in exercise-induced cardioprotection of C57Bl6 mice fed with high fat and sucrose diet (HFS) for 12 weeks and subjected or not to exercise training during the last 4 weeks (HFS-Ex). HFS animals were more sensitive to in vivo and ex vivo IR injuries than control (normal diet) and HFS-Ex mice. Cardioprotection in HFS-Ex mice was not associated with increased myocardial eNOS activation and NO metabolites storage, possibly due to the β3AR-eNOS pathway functional loss in their heart. Indeed, a selective β3AR agonist (BRL37344) increased eNOS activation and had a protective effect against IR in control, but not in HFS hearts. Moreover, iNOS expression, nitro-oxidative stress (protein s-nitrosylation and nitrotyrosination) and ROS production during early reperfusion were increased in HFS, but not in control mice. Exercise normalized iNOS level and reduced protein s-nitrosylation, nitrotyrosination and ROS production in HFS-Ex hearts during early reperfusion. The iNOS inhibitor 1400 W reduced in vivo infarct size in HFS mice to control levels, supporting the potential role of iNOS normalization in the cardioprotective effects of exercise training in HFS-Ex mice. Although the β3AR-eNOS pathway is defective in the heart of HFS mice, regular exercise can protect their heart against IR by reducing iNOS expression and nitro-oxidative stress.

  14. Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter.

    PubMed Central

    de Vera, M E; Shapiro, R A; Nussler, A K; Mudgett, J S; Simmons, R L; Morris, S M; Billiar, T R; Geller, D A

    1996-01-01

    The expression of inducible nitric oxide synthase (NOS2) is complex and is regulated in part by gene transcription. In this investigation we studied the regulation of NOS2 in a human liver epithelial cell line (AKN-1) which expresses high levels of NOS2 mRNA and protein in response to tumor necrosis factor alpha, interleukin 1 beta, and interferon gamma (cytokine mix, CM). Nuclear run-on analysis revealed that CM transcriptionally activated the human NOS2 gene. To delineate the cytokine-responsive regions of the human NOS2 promoter, we stimulated AKN-1 cells with CM following transfection of NOS2 luciferase constructs. Analysis of the first 3.8 kb upstream of the NOS2 gene demonstrated basal promoter activity but failed to show any cytokine-inducible activity. However, 3- to 5-fold inductions of luciferase activity were seen in constructs extending up to -5.8 and -7.0 kg, and a 10-fold increase was seen upon transfection of a -16 kb construct. Further analysis of various NOS2 luciferase constructs ligated upstream of the thymidine kinase promoter identified three regions containing cytokine-responsive elements in the human NOS2 gene: -3.8 to -5.8, -5.8 to -7.0, and -7.0 to -16 kb. These results are in marked contrast with the murine macrophage NOS2 promoter in which only 1 kb of the proximal 5' flanking region is necessary to confer inducibility to lipopolysaccharide and interferon gamma. These data demonstrate that the human NOS2 gene is transcriptionally regulated by cytokines and identify multiple cytokine-responsive regions in the 5' flanking region of the human NOS2 gene. Images Fig. 1 Fig. 2 PMID:8577713

  15. Federal Wind Energy Research Program

    SciTech Connect

    Not Available

    1991-10-01

    The Office of Program Analysis (OPA) undertook an assessment of 55 research projects sponsored by the Federal Wind Energy Research Program. This report summarizes the results of that review. In accordance with statue and policy guidance, the program's research has targeted the sciences of wind turbine dynamics and the development of advanced components and systems. Wind turbine research has focused on atmospheric fluid dynamics, aerodynamics, and structural dynamics. Rating factors including project scientific and technical merit, appropriateness and level of innovation of the technical approach, quality of the project team, productivity, and probable impact on the program's mission. Each project was also given an overall evaluation supported with written comments. 1 fig.

  16. Federal Facility Agreement progress report

    SciTech Connect

    Not Available

    1993-10-01

    The (SRS) Federal Facility Agreement (FFA) was made effective by the US. Environmental Protection Agency Region IV (EPA) on August 16, 1993. To meet the reporting requirements in Section XXV of the Agreement, the FFA Progress Report was developed. The FFA Progress Report is the first of a series of quarterly progress reports to be prepared by the SRS. As such this report describes the information and action taken to September 30, 1993 on the SRS units identified for investigation and remediation in the Agreement. This includes; rubble pits, runoff basins, retention basin, seepage basin, burning pits, H-Area Tank 16, and spill areas.

  17. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...

  18. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...

  19. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...

  20. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...

  1. Federal Employment of People with Disabilities

    ERIC Educational Resources Information Center

    Domzal, Christine

    2009-01-01

    The purpose of this paper is to examine the status of employment of people with disabilities in the Federal Government and to make recommendations for improving federal hiring and advancement of employees with disabilities. The paper summarizes the legal authorities and policy guidance, the responsibilities of various federal agencies charged with…

  2. 36 CFR 1253.8 - Federal Register.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Federal Register. 1253.8... AVAILABILITY AND USE LOCATION OF NARA FACILITIES AND HOURS OF USE § 1253.8 Federal Register. The location and business hours of the Office of the Federal Register are posted at http://www.archives.gov, and codified...

  3. 36 CFR 1253.8 - Federal Register.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Federal Register. 1253.8... AVAILABILITY AND USE LOCATION OF NARA FACILITIES AND HOURS OF USE § 1253.8 Federal Register. The location and business hours of the Office of the Federal Register are posted at http://www.archives.gov, and codified...

  4. 36 CFR 1253.8 - Federal Register.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Federal Register. 1253.8... AVAILABILITY AND USE LOCATION OF NARA FACILITIES AND HOURS OF USE § 1253.8 Federal Register. The location and business hours of the Office of the Federal Register are posted at http://www.archives.gov, and codified...

  5. 36 CFR 1253.8 - Federal Register.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Federal Register. 1253.8... AVAILABILITY AND USE LOCATION OF NARA FACILITIES AND HOURS OF USE § 1253.8 Federal Register. The location and business hours of the Office of the Federal Register are posted at http://www.archives.gov, and codified...

  6. The Federal Role in Postsecondary Education.

    ERIC Educational Resources Information Center

    Hodgkinson, Virginia A.

    The federal role in postsecondary education since 1787 is traced. Attention is directed to the types of indirect federal support toward postsecondary education until the first Higher Education Act of 1965, and the kinds of national priorities served by the current federal role in postsecondary education. Future projections and the implications of…

  7. 75 FR 61552 - Federal Railroad Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... Federal Railroad Administration Notice of Informational Filing In accordance with Section 236.913 of Title 49 of the Code of Federal Regulations (CFR), notice is hereby given that the Federal Railroad Administration (FRA) has received an informational filing from the Northeast Illinois Regional Commuter...

  8. Survey of Federal Libraries; Fiscal Year 1972.

    ERIC Educational Resources Information Center

    National Center for Educational Statistics (DHEW/OE), Washington, DC.

    The fourth study of federal libraries provided the first nearly complete statistical survey of all federal libraries in the continental United States and overseas. It was anticipated that the results of the study could serve as a landmark for future federal planning and as a guide for the library community in responding to related activities on…

  9. Federal Student Aid Annual Report, 2010

    ERIC Educational Resources Information Center

    US Department of Education, 2010

    2010-01-01

    This paper presents the Federal Student Aid Annual Report for 2010. Federal Student Aid experienced an extraordinary year in 2010. The passage and enactment of the Health Care and Education Reconciliation Act of 2010 ushered in sweeping reforms to the federal student financial assistance programs, resulting in tens of billions of dollars in…

  10. 13 CFR 314.5 - Federal Share.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Federal Share. 314.5 Section 314.5 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE PROPERTY General § 314.5 Federal Share. (a) For purposes of this part, “Federal Share” means that portion of the...

  11. 78 FR 25524 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... TRANSPORTATION Federal Aviation Administration Notice of Request To Release Airport Property AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Intent to Rule on Request to Release Airport Property..., Airports Compliance Specialist, Federal Aviation Administration, Airports Division, ACE- 610C, 901...

  12. 23 CFR 750.305 - Federal participation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Federal participation. 750.305 Section 750.305 Highways... participation. (a) Federal funds may participate in: (1) Payments made to a sign owner for his right, title and... personnel on a force account basis or by contract. Documentation for Federal participation in such...

  13. 23 CFR 750.305 - Federal participation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Federal participation. 750.305 Section 750.305 Highways... participation. (a) Federal funds may participate in: (1) Payments made to a sign owner for his right, title and... personnel on a force account basis or by contract. Documentation for Federal participation in such...

  14. 23 CFR 652.9 - Federal participation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Federal participation. 652.9 Section 652.9 Highways... AND BICYCLE ACCOMMODATIONS AND PROJECTS § 652.9 Federal participation. (a) Independent walkway... exceeded. (b) Specific eligibility requirements for Federal-aid participation in independent...

  15. 23 CFR 652.9 - Federal participation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Federal participation. 652.9 Section 652.9 Highways... AND BICYCLE ACCOMMODATIONS AND PROJECTS § 652.9 Federal participation. (a) Independent walkway... exceeded. (b) Specific eligibility requirements for Federal-aid participation in independent...

  16. 29 CFR 4.107 - Federal contracts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Federal contracts. 4.107 Section 4.107 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Agencies Whose Contracts May Be Covered § 4.107 Federal contracts. (a) Section 2(a) of the...

  17. 23 CFR 652.9 - Federal participation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Federal participation. 652.9 Section 652.9 Highways... AND BICYCLE ACCOMMODATIONS AND PROJECTS § 652.9 Federal participation. (a) Independent walkway... exceeded. (b) Specific eligibility requirements for Federal-aid participation in independent...

  18. 23 CFR 772.15 - Federal participation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Federal participation. 772.15 Section 772.15 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT PROCEDURES FOR ABATEMENT OF HIGHWAY TRAFFIC NOISE AND CONSTRUCTION NOISE § 772.15 Federal participation. (a) Type I...

  19. 23 CFR 750.305 - Federal participation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Federal participation. 750.305 Section 750.305 Highways... participation. (a) Federal funds may participate in: (1) Payments made to a sign owner for his right, title and... personnel on a force account basis or by contract. Documentation for Federal participation in such...

  20. 23 CFR 772.15 - Federal participation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Federal participation. 772.15 Section 772.15 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT PROCEDURES FOR ABATEMENT OF HIGHWAY TRAFFIC NOISE AND CONSTRUCTION NOISE § 772.15 Federal participation. (a) Type I...

  1. 23 CFR 750.305 - Federal participation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Federal participation. 750.305 Section 750.305 Highways... participation. (a) Federal funds may participate in: (1) Payments made to a sign owner for his right, title and... personnel on a force account basis or by contract. Documentation for Federal participation in such...

  2. 23 CFR 750.305 - Federal participation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Federal participation. 750.305 Section 750.305 Highways... participation. (a) Federal funds may participate in: (1) Payments made to a sign owner for his right, title and... personnel on a force account basis or by contract. Documentation for Federal participation in such...

  3. 23 CFR 652.9 - Federal participation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Federal participation. 652.9 Section 652.9 Highways... AND BICYCLE ACCOMMODATIONS AND PROJECTS § 652.9 Federal participation. (a) Independent walkway... exceeded. (b) Specific eligibility requirements for Federal-aid participation in independent...

  4. 23 CFR 772.15 - Federal participation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Federal participation. 772.15 Section 772.15 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT PROCEDURES FOR ABATEMENT OF HIGHWAY TRAFFIC NOISE AND CONSTRUCTION NOISE § 772.15 Federal participation. (a) Type I...

  5. 23 CFR 652.9 - Federal participation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Federal participation. 652.9 Section 652.9 Highways... AND BICYCLE ACCOMMODATIONS AND PROJECTS § 652.9 Federal participation. (a) Independent walkway... exceeded. (b) Specific eligibility requirements for Federal-aid participation in independent...

  6. 40 CFR 62.13 - Federal plans.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 9 2013-07-01 2013-07-01 false Federal plans. 62.13 Section 62.13... PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS General Provisions § 62.13 Federal plans. The Federal plans apply to owners and operators of affected facilities that are not covered by an...

  7. 40 CFR 58.60 - Federal monitoring.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... QUALITY SURVEILLANCE Federal Monitoring § 58.60 Federal monitoring. The Administrator may locate and operate an ambient air monitoring site if the State or local agency fails to locate, or schedule to be... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Federal monitoring. 58.60 Section...

  8. 29 CFR 4.107 - Federal contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Federal contracts. 4.107 Section 4.107 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Agencies Whose Contracts May Be Covered § 4.107 Federal contracts. (a) Section 2(a) of the...

  9. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...

  10. Female Offenders in the Federal Correctional System.

    ERIC Educational Resources Information Center

    Foster, Euphesenia

    The illustrated booklet provides a brief history of Federal prisons and of Federal women's prisons. There is statistical information on women prisoners classified by age, race, period of confinement, marital status, type of crime, and judicial district from which the commitment was made. Tables for the Federal Reformatory for Women, Alderson, West…

  11. Leasing of federal geothermal resources

    NASA Technical Reports Server (NTRS)

    Stone, R. T.

    1974-01-01

    Pursuant to the Geothermal Steam Act of 1970 and the regulations published on December 21, 1973, the first Federal geothermal competitive lease sale was held on January 22, 1974, by the Department of the Interior, offering 33 tracts totalling over 50,000 acres in three Known Geothermal Resource Areas in California. On January 1, 1974, Federal lands outside Known Geothermal Resource Areas were opened to noncompetitive lease applications, of which, 3,763 had been received by June 1, 1974. During fiscal year 1974, a total of 22 competitive leases had been issued in California and Oregon. The principal components in the Department involved in the leasing program are the Geological Survey and the Bureau of Land Management. The former has jurisdiction over drilling and production operations and other activities in the immediate area of operations. The latter receives applications and issues leases and is responsible for managing leased lands under its jurisdiction outside the area of operations. The interrelationships of the above agencies and the procedures in the leasing program are discussed.

  12. Study of federal microwave standards

    SciTech Connect

    David, L.

    1980-08-01

    Present and future federal regulatory processes which may impact the permissible levels of microwave radiation emitted by the SPS Microwave Power Transmission (MPTS) were studied. An historical development of US occupational and public microwave standards includes an overview of Western and East European philosophies of environmental protection and neurophysiology which have led to the current widely differing maximum permissible exposure limits to microwaves. The possible convergence of microwave standards is characterized by a lowering of Western exposure levels while Eastern countries consider standard relaxation. A trend toward stricter controls on activities perceived as harmful to public health is under way as is interest in improving the federal regulatory process. Particularly relevant to SPS is the initiation of long-term, low-level microwave exposure programs. Coupled with new developments in instrumentation and dosimetry, the results from chronic exposure program and population exposure studies could be expected within the next five to ten years. Also discussed is the increasing public concern that rf energy is yet another hazardous environmental agent.

  13. 77 FR 47374 - Notice of Proposed Information Collection Requests; Federal Student Aid; William D. Ford Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    ... William D. Ford Federal Direct Loan (Direct Loan) and Federal Family Education Loan (FFEL) Programs may... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION... Loan (Direct Loan) Program/ Federal Family Loan (FFEL) Program: Deferment Request Forms...

  14. 49 CFR 613.300 - Coordination of Federal and federally assisted programs and projects.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... programs and projects. 613.300 Section 613.300 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING ASSISTANCE AND STANDARDS Coordination of Federal and Federally Assisted Programs and Projects § 613.300 Coordination of Federal...

  15. 49 CFR 613.300 - Coordination of Federal and federally assisted programs and projects.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... programs and projects. 613.300 Section 613.300 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING ASSISTANCE AND STANDARDS Coordination of Federal and Federally Assisted Programs and Projects § 613.300 Coordination of Federal...

  16. 44 CFR Appendix A to Part 62 - Federal Emergency Management Agency, Federal Insurance Administration, Financial Assistance...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Federal Emergency Management... 62 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... OF CLAIMS Pt. 62, App. A Appendix A to Part 62—Federal Emergency Management Agency, Federal...

  17. 41 CFR 102-74.180 - What illumination levels must Federal agencies maintain on Federal facilities?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What illumination levels must Federal agencies maintain on Federal facilities? 102-74.180 Section 102-74.180 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL...

  18. 41 CFR 102-74.180 - What illumination levels must Federal agencies maintain on Federal facilities?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What illumination levels must Federal agencies maintain on Federal facilities? 102-74.180 Section 102-74.180 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL...

  19. 41 CFR 102-74.180 - What illumination levels must Federal agencies maintain on Federal facilities?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What illumination levels must Federal agencies maintain on Federal facilities? 102-74.180 Section 102-74.180 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL...

  20. Promoting cooperative federalism through state shared savings.

    PubMed

    Weil, Alan

    2013-08-01

    The Affordable Care Act is transforming American federalism and creating strain between the states and the federal government. By expanding the scale of intergovernmental health programs, creating new state requirements, and setting the stage for increased federal fiscal oversight, the act has disturbed an uneasy truce in American federalism. This article outlines a policy proposal designed to harness cooperative federalism, based on the shared state and federal desire to control health care cost growth. The proposal, which borrows features of the Medicare Shared Savings Program, would provide states with an incentive in the form of an increased share of the savings they generate in programs that have federal financial participation, as long as they meet defined performance standards.

  1. Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.

    PubMed

    Claramunt, Rosa M; López, Concepción; Pérez-Medina, Carlos; Pérez-Torralba, Marta; Elguero, José; Escames, Germaine; Acuña-Castroviejo, Darío

    2009-09-01

    In order to find new compounds with neuroprotective activity and NOS-I/NOS-II selectivity, we have designed, synthesized, and characterized 14 new NOS inhibitors with an indazole structure. The first group corresponds to 4,5,6,7-tetrahydroindazoles (4-8), the second to the N-methyl derivatives (9-12) of 7-nitro-1H-indazole (1) and 3-bromo-7-nitro-1H-indazole (2), and the latter to 4,5,6,7-tetrafluoroindazoles (13-17). Compound 13 (4,5,6,7-tetrafluoro-3-methyl-1H-indazole) inhibited NOS-I by 63% and NOS-II by 83%. Interestingly, compound 16 (4,5,6,7-tetrafluoro-3-perfluorophenyl-1H-indazole) inhibited NOS-II activity by 80%, but it did not affect to NOS-I activity. Structural comparison between these new indazoles further supports the importance of the aromatic indazole skeleton for NOS inhibition and indicate that bulky groups or N-methylation of 1 and 2 diminish their effect on NOS activity. The fluorination of the aromatic ring increased the inhibitory potency and NOS-II selectivity, suggesting that this is a promising strategy for NOS selective inhibitors.

  2. Federal Environmental Reporting Requirements Handbook

    SciTech Connect

    1990-05-01

    The Environmental Reporting Requirements Handbook has been developed by DOE Headquarters' Environmental Guidance Division (EH-231) in order to assist DOE Field Organizations in the identification of the various reporting the notification requirements mandated by Federal environmental laws, regulations, and Executive Orders. The Handbook makes a distinction between ''routine'' and ''non-routine'' reporting/notification requirements. Routine reporting requirements include the submission of documents that are required either on a regular basis, such as annual or biennial reports, or periodic notifications that result from what would be considered ''normal'' operations, such as Material Safety Data Sheet (MSDS) updates that are required when new information not contained on previous MSDS submissions is discovered. Non-routine reporting requirements are generally associated with occurrences that represent significant deviations from regulated or planned performance; examples include the unintentional discharge of oil or hazardous substances.

  3. Stromal cell–derived factor 2 is critical for Hsp90-dependent eNOS activation

    PubMed Central

    Siragusa, Mauro; Fröhlich, Florian; Park, Eon Joo; Schleicher, Michael; Walther, Tobias C.; Sessa, William C.

    2016-01-01

    Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of l-arginine and molecular oxygen into l-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease. Several mechanisms regulate eNOS activity and function, including phosphorylation at Ser and Thr residues and protein-protein interactions. Combining a tandem affinity purification approach and mass spectrometry, we identified stromal cell–derived factor 2 (SDF2) as a component of the eNOS macromolecular complex in endothelial cells. SDF2 knockdown impaired agonist-stimulated NO synthesis and decreased the phosphorylation of eNOS at Ser1177, a key event required for maximal activation of eNOS. Conversely, SDF2 overexpression dose-dependently increased NO synthesis through a mechanism involving Akt and calcium (induced with ionomycin), which increased the phosphorylation of Ser1177 in eNOS. NO synthesis by iNOS (inducible NOS) and nNOS (neuronal NOS) was also enhanced upon SDF2 overexpression. We found that SDF2 was a client protein of the chaperone protein Hsp90, interacting preferentially with the M domain of Hsp90, which is the same domain that binds to eNOS. In endothelial cells exposed to vascular endothelial growth factor (VEGF), SDF2 was required for the binding of Hsp90 and calmodulin to eNOS, resulting in eNOS phosphorylation and activation. Thus, our data describe a function for SDF2 as a component of the Hsp90-eNOS complex that is critical for signal transduction in endothelial cells. PMID:26286023

  4. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene

    SciTech Connect

    Robinson, L.J.; Michel, T.; Weremowicz, S.; Morton, C.C. )

    1994-01-15

    Endothelial NOS activity is a major determinant of vascular tone and blood pressure, and in several important (and sometimes hereditary) disease states, such as hypertension, diabetes, and atherosclerosis, the endothelial NO signaling system appears to be abnormal. To explore the relationship of the endothelial NOS activity, the authors isolated the human gene encoding the endothelial NOS. Genomic clones containing the 5[prime] end of this gene were identified in a human genomic library by applying a polymerase chain reaction (PCR)-based approach. Identification of the human gene for endothelial NOS (NOS3) was confirmed by nucleotide sequence analysis of the first coding exon, which was found to be identical to its cognate cDNA. The NOS3 gene spans at least 20 kb and appears to contain multiple introns. The transcription start site and promoter region of the NOS3 gene were identified by primer extension and ribonuclease protection assays. Sequencing of the putative promoter revealed consensus sequences for the shear stress-response element, as well as cytokine-responsive cis regulatory sequences, both possible important to the roles played by NOS3 in the normal and the diseased cardiovascular system. The authors also mapped the chromosomal location of the NOS3 gene. First, a chromosomal panel of human-rodent somatic cell hybrids was screened using PCR with oligonucleotide primers derived from the NOS3 genomic clone. The specificity of the amplified PCR product was confirmed by human and hamster genomic DNA controls, as well as by Southern blot analysis, using the NOS3 cDNA as probe. Definitive chromosomal assignment of the NOS3 gene to human chromosome 7 was based upon 0% discordancy; fluorescence in situ hybridization sublocalized the NOS3 gene to 7q36. The identification and characterization of the NOS3 gene may lead to further insights into heritable disease states associated with this gene product. 41 refs., 3 figs., 1 tab.

  5. 14. "TEST STANDS NOS. 11, 13, & 15; MISCELLANEOUS DETAILS." ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. "TEST STANDS NOS. 1-1, 1-3, & 1-5; MISCELLANEOUS DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/22, Rev. D. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04-353 Eng. 177, Rev. D, no change; Date: 17 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  6. 11. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/15, Rev. E. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. E; Date: 21 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  7. 15. "TEST STANDS NOS. 11, 13, & 15; STRUCTURAL STEEL; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. "TEST STANDS NOS. 1-1, 1-3, & 1-5; STRUCTURAL STEEL; PLAN & DETAILS." Specifications No. ENG 04-353-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/34, Rev. A. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. A, no change; Date: 21 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  8. 13. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/18, Rev. D. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. D, no change; Date: 18 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  9. 10. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/14, Rev. B. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. B; Date: 21 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  10. 12. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-06; no sheet number within title block. D.O. SERIES 1109/16, Rev. E. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. E; Date: 26 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  11. 9. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. ENG 04-35350-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/13. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, no change; Date: 17 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  12. 16. "TEST STANDS NOS. 11, 13, & 15; STRUCTURAL STEEL; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. "TEST STANDS NOS. 1-1, 1-3, & 1-5; STRUCTURAL STEEL; ELEVATIONS AND SECTIONS." Specifications No. ENG 04353-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/35, Rev. A. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04-353 Eng. 177, Rev. A; Date: 29 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  13. 102. Interior view of utilidor passageway link between building nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    102. Interior view of utilidor passageway link between building nos. 101 and 102 showing waveguides on left and cable tray system on right sides. Note fire suppression water supply piping (upper center). Small maintenance 3-wheel vehicle at center (Note: similar vehicles still in use in 2001.) Official photograph BMEWS Project by Hansen, Photographic Services, Riverton, NJ, BMEWS, clear as negative no. A-101123. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  14. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions about Using History of Science to Teach NOS

    ERIC Educational Resources Information Center

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-01-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing…

  15. The Domino Effects of Federal Research Funding.

    PubMed

    Lanahan, Lauren; Graddy-Reed, Alexandra; Feldman, Maryann P

    2016-01-01

    The extent to which federal investment in research crowds out or decreases incentives for investment from other funding sources remains an open question. Scholarship on research funding has focused on the relationship between federal and industry or, more comprehensively, non-federal funding without disentangling the other sources of research support that include nonprofit organizations and state and local governments. This paper extends our understanding of academic research support by considering the relationships between federal and non-federal funding sources provided by the National Science Foundation Higher Education Research and Development Survey. We examine whether federal research investment serves as a complement or substitute for state and local government, nonprofit, and industry research investment using the population of research-active academic science fields at U.S. doctoral granting institutions. We use a system of two equations that instruments with prior levels of both federal and non-federal funding sources and accounts for time-invariant academic institution-field effects through first differencing. We estimate that a 1% increase in federal research funding is associated with a 0.411% increase in nonprofit research funding, a 0.217% increase in state and local research funding, and a 0.468% increase in industry research funding, respectively. Results indicate that federal funding plays a fundamental role in inducing complementary investments from other funding sources, with impacts varying across academic division, research capacity, and institutional control.

  16. The Domino Effects of Federal Research Funding

    PubMed Central

    Graddy-Reed, Alexandra; Feldman, Maryann P.

    2016-01-01

    The extent to which federal investment in research crowds out or decreases incentives for investment from other funding sources remains an open question. Scholarship on research funding has focused on the relationship between federal and industry or, more comprehensively, non-federal funding without disentangling the other sources of research support that include nonprofit organizations and state and local governments. This paper extends our understanding of academic research support by considering the relationships between federal and non-federal funding sources provided by the National Science Foundation Higher Education Research and Development Survey. We examine whether federal research investment serves as a complement or substitute for state and local government, nonprofit, and industry research investment using the population of research-active academic science fields at U.S. doctoral granting institutions. We use a system of two equations that instruments with prior levels of both federal and non-federal funding sources and accounts for time-invariant academic institution-field effects through first differencing. We estimate that a 1% increase in federal research funding is associated with a 0.411% increase in nonprofit research funding, a 0.217% increase in state and local research funding, and a 0.468% increase in industry research funding, respectively. Results indicate that federal funding plays a fundamental role in inducing complementary investments from other funding sources, with impacts varying across academic division, research capacity, and institutional control. PMID:27327509

  17. PV opportunities in the Federal sector

    NASA Astrophysics Data System (ADS)

    Thornton, John P.

    1996-01-01

    The Federal government is the largest user of energy in the United States today. The Department of Defense (DOD) uses more than 80% of that energy; the Department of Energy is the second largest user. In the 15 years from 1975 to 1989, 128 billion was spent for Federal energy activities. In 1989 alone, the Federal government spent a total of 8.7 billion on energy, of which 3.5 billion was for buildings and 2.4 billion was for electricity. The Federal government, which owns or leases 500,000 buildings, provided an additional 3.9 billion on energy assistance for low-income housing in 1989 (1). Executive Order 12902 (Energy Efficiency and Water Conservation at Federal Facilities) of March 8, 1994 implements and expands the Federal energy management provisions stated in the Energy Policy Act (EPAct) of 1992. The goal is to reduce energy use in Federal buildings to 30% of the 1985 levels by the year 2005. The Federal Energy Management Program (FEMP) has been assigned the responsibility of implementing Executive Order 12902. Subsequently, DOE, FEMP, other Federal agencies and private industry have formed a unique partnership to develop a process and set of actions that will stimulate new opportunities for renewable energy technologies. If these Federal initiatives are successful, substantial investment in renewable and energy efficiency technologies will be stimulated, an important portion of the nation's energy needs will be supplied, and a significant reduction in greenhouse gas emissions will be achieved.

  18. Adaptive Runge-Kutta integration for stiff systems: Comparing Nosé and Nosé-Hoover dynamics for the harmonic oscillator

    NASA Astrophysics Data System (ADS)

    Graham Hoover, William; Clinton Sprott, Julien; Griswold Hoover, Carol

    2016-10-01

    We describe the application of adaptive (variable time step) integrators to stiff differential equations encountered in many applications. Linear harmonic oscillators subject to nonlinear thermal constraints can exhibit either stiff or smooth dynamics. Two closely related examples, Nosé's dynamics and Nosé-Hoover dynamics, are both based on Hamiltonian mechanics and generate microstates consistent with Gibbs' canonical ensemble. Nosé's dynamics is stiff and can present severe numerical difficulties. Nosé-Hoover dynamics, although it follows exactly the same trajectory, is smooth and relatively trouble-free. We emphasize the power of adaptive integrators to resolve stiff problems such as the Nosé dynamics for the harmonic oscillator. The solutions also illustrate the power of computer graphics to enrich numerical solutions.

  19. The return of the Scarlet Pimpernel: cobalamin in inflammation II — cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS

    PubMed Central

    Wheatley, Carmen

    2007-01-01

    The up-regulation of transcobalamins [hitherto posited as indicating a central need for cobalamin (Cbl) in inflammation], whose expression, like inducible nitric oxide synthase (iNOS), is Sp1- and interferondependent, together with increased intracellular formation of glutathionylcobalamin (GSCbl), adenosylcobalamin (AdoCbl), methylcobalamin (MeCbl), may be essential for the timely promotion and later selective inhibition of iNOS and concordant regulation of endothelial and neuronal NOS (eNOS/nNOS.) Cbl may ensure controlled high output of nitric oxide (NO) and its safe deployment, because: (1) Cbl is ultimately responsible for the synthesis or availability of the NOS substrates and cofactors heme, arginine, BH4 flavin adenine dinucleotide/flavin mononucleotide (FAD/FMN) and NADPH, via the far-reaching effects of the two Cbl coenzymes, methionine synthase (MS) and methylmalonyl CoA mutase (MCoAM) in, or on, the folate, glutathione, tricarboxylic acid (TCA) and urea cycles, oxidative phosphorylation, glycolysis and the pentose phosphate pathway. Deficiency of any of theNOS substrates and cofactors results in ‘uncoupled’ NOS reactions, decreasedNO production and increased or excessive O2−, H2O2, ONOO− and other reactive oxygen species (ROS), reactive nitric oxide species (RNIS) leading to pathology. (2) Cbl is also the overlooked ultimate determinant of positive glutathione status, which favours the formation of more benign NO species, s-nitrosothiols, the predominant form in which NO is safely deployed. Cbl status may consequently act as a ‘back-up disc’ that ensures the active status of antioxidant systems, as well as reversing and modulating the effects of nitrosylation in cell signal transduction.New evidence shows that GSCbl can significantly promote iNOS/ eNOS NO synthesis in the early stages of inflammation, thus lowering high levels of tumour necrosis factor-a that normally result in pathology, while existing evidence shows that in extreme

  20. Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation

    PubMed Central

    Das, Amlan; Gopalakrishnan, Bhavani; Druhan, Lawrence J; Wang, Tse-Yao; De Pascali, Francesco; Rockenbauer, Antal; Racoma, Ira; Varadharaj, Saradhadevi; Zweier, Jay L; Cardounel, Arturo J; Villamena, Frederick A

    2014-01-01

    Background and Purpose Nitric oxide (NO) derived from eNOS is mostly responsible for the maintenance of vascular homeostasis and its decreased bioavailability is characteristic of reactive oxygen species (ROS)-induced endothelial dysfunction (ED). Because 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), a commonly used spin trap, can control intracellular nitroso-redox balance by scavenging ROS and donating NO, it was employed as a cardioprotective agent against ED but the mechanism of its protection is still not clear. This study elucidated the mechanism of protection by DMPO against SIN-1-induced oxidative injury to bovine aortic endothelial cells (BAEC). Experimental Approach BAEC were treated with SIN-1, as a source of peroxynitrite anion (ONOO−), and then incubated with DMPO. Cytotoxicity following SIN-1 alone and cytoprotection by adding DMPO was assessed by MTT assay. Levels of ROS and NO generation from HEK293 cells transfected with wild-type and mutant eNOS cDNAs, tetrahydrobiopterin bioavailability, eNOS activity, eNOS and Akt kinase phosphorylation were measured. Key Results Post-treatment of cells with DMPO attenuated SIN-1-mediated cytotoxicity and ROS generation, restoration of NO levels via increased in eNOS activity and phospho-eNOS levels. Treatment with DMPO alone significantly increased NO levels and induced phosphorylation of eNOS Ser1179 via Akt kinase. Transfection studies with wild-type and mutant human eNOS confirmed the dual role of eNOS as a producer of superoxide anion (O2−) with SIN-1 treatment, and a producer of NO in the presence of DMPO. Conclusion and Implications Post-treatment with DMPO of oxidatively challenged cells reversed eNOS dysfunction and could have pharmacological implications in the treatment of cardiovascular diseases. PMID:24405159

  1. Galilean-invariant Nosé-Hoover-type thermostats

    NASA Astrophysics Data System (ADS)

    Pieprzyk, S.; Heyes, D. M.; Maćkowiak, Sz.; Brańka, A. C.

    2015-03-01

    A new pairwise Nosé-Hoover type thermostat for molecular dynamics (MD) simulations which is similar in construction to the pair-velocity thermostat of Allen and Schmid, [Mol. Simul. 33, 21 (2007), 10.1080/08927020601052856] (AS) but is based on the configurational thermostat is proposed and tested. Both thermostats generate the canonical velocity distribution, are Galilean invariant, and conserve linear and angular momentum. The unique feature of the pairwise thermostats is an unconditional conservation of the total angular momentum, which is important for thermalizing isolated systems and those nonequilibrium bulk systems manifesting local rotating currents. These thermostats were benchmarked against the corresponding Nosé-Hoover (NH) and Braga-Travis prescriptions, being based on the kinetic and configurational definitions of temperature, respectively. Some differences between the shear-rate-dependent shear viscosity from Sllod nonequilibrium MD are observed at high shear rates using the different thermostats. The thermostats based on the configurational temperature produced very similar monotically decaying shear viscosity (shear thinning) with increasing shear rate, while the NH method showed discontinuous shear thinning into a string phase, and the AS method produced a continuous increase of viscosity (shear thickening), after a shear thinning region at lower shear rates. Both pairwise additive thermostats are neither purely kinetic nor configurational in definition, and possible directions for further improvement in certain aspects are discussed.

  2. On the configurational temperature Nosè-Hoover thermostat

    NASA Astrophysics Data System (ADS)

    Beckedahl, Derrick; Obaga, Emmanuel O.; Uken, Daniel A.; Sergi, Alessandro; Ferrario, Mauro

    2016-11-01

    In this paper we reformulate the configurational temperature Nosé-Hoover thermostat of Braga and Travis (2005) by means of a quasi-Hamiltonian theory in phase space Sergi and Ferrario (2001). The quasi-Hamiltonian structure is exploited to introduce a hybrid configurational-kinetic temperature Nosé-Hoover chain thermostat that can achieve a uniform sampling of phase space (also for stiff harmonic systems), as illustrated by simulating the dynamics of one-dimensional harmonic and quartic oscillators. An integration algorithm, based on the symmetric Trotter decomposition of the propagator, is presented and tested against implicit geometric algorithms with a structure similar to the velocity and position Verlet. In order to obtain an explicit form for the symmetric Trotter propagator algorithm, in the case of non-harmonic and non-linear interaction potentials, a position-dependent harmonically approximated propagator is introduced. Such a propagator approximates the dynamics of the configurational degrees of freedom as if they were locally moving in a harmonic potential. The resulting approximated locally harmonic dynamics is tested with good results in the case of a one-dimensional quartic oscillator: The integration is stable and locally time-reversible. Instead, the implicit geometric integrator is stable and time-reversible globally (when convergence is achieved). We also verify the stability of the approximated explicit integrator for a three-dimensional N-particle system interacting through a soft Weeks-Chandler-Andersen potential.

  3. Scanning capacitance detection and charge trapping in NOS

    NASA Astrophysics Data System (ADS)

    Terris, Bruce D.; Barrett, Rick; Mamin, H. Jonathon

    1993-06-01

    Charge trapping in thin films of silicon nitride has long been studied for use as a non-volatile semiconductor memory. Recently, this technology has been combined with scanned probe technologies with the sharp probe tip serving as the upper electrode in a Si3N4- SiO2Si (NOS) structure. By applying a voltage pulse between the tip and silicon substrate, charge carriers can be made to tunnel through the oxide and be trapped in the nitride. This trapped charge causes a shift in the capacitance-voltage curve along the voltage axis; the voltage at which depletion occurs is increased. It has been proposed that such a system could be used as a high density data storage device. We have begun to explore some of the issues related to such an application, including data lifetime and data rates. In thermally accelerated life tests, no sign of charge spreading was seen after 100 days at 150 degree(s)C and from the rate of charge decay we would predict room temperature lifetimes in excess of 1 million years. We have also used an air-bearing spindle to conduct high speed measurements on a spinning NOS sample and obtained data rates as high as 500 kHz with carrier-to-noise ratios of approximately 60 dB in a 3 kHz bandwidth.

  4. A configurational temperature Nosé-Hoover thermostat.

    PubMed

    Braga, Carlos; Travis, Karl P

    2005-10-01

    We propose two new thermostats which can be employed in computer simulations to ensure that two different variants of the configurational temperature fluctuate around their equilibrium values. These new thermostats differ from one previously introduced by Delhommelle and Evans [Mol. Phys. 99, 1825 (2001)] in several important ways. First, our thermostats are derived in the same spirit as the Nosé-Hoover thermostat and therefore generate the canonical phase-space distribution. Second, our thermostats involve simpler equations of motion, which do not involve spatial gradients of the configurational temperature. They do not suffer from problems stemming from stiff equations of motion and furthermore, in large temperature perturbation simulations, the measured temperature follows the set-point temperature without any overshoot, and with good damping of oscillations. We show that both of our configurational thermostats are special cases of a more general set of Nosé-Hoover equations proposed by Kusnezov et al. [Ann. Phys. 204, 155 (1990)]. The new thermostats are expected to be highly useful in nonequilibrium simulations, particularly those characterized by spatial inhomogeneities. They should also find applicability in simulations involving large changes in temperature over small time scales, such as temperature quench molecular dynamics and radiation damage modeling.

  5. Galilean-invariant Nosé-Hoover-type thermostats.

    PubMed

    Pieprzyk, S; Heyes, D M; Maćkowiak, Sz; Brańka, A C

    2015-03-01

    A new pairwise Nosé-Hoover type thermostat for molecular dynamics (MD) simulations which is similar in construction to the pair-velocity thermostat of Allen and Schmid, [Mol. Simul. 33, 21 (2007)] (AS) but is based on the configurational thermostat is proposed and tested. Both thermostats generate the canonical velocity distribution, are Galilean invariant, and conserve linear and angular momentum. The unique feature of the pairwise thermostats is an unconditional conservation of the total angular momentum, which is important for thermalizing isolated systems and those nonequilibrium bulk systems manifesting local rotating currents. These thermostats were benchmarked against the corresponding Nosé-Hoover (NH) and Braga-Travis prescriptions, being based on the kinetic and configurational definitions of temperature, respectively. Some differences between the shear-rate-dependent shear viscosity from Sllod nonequilibrium MD are observed at high shear rates using the different thermostats. The thermostats based on the configurational temperature produced very similar monotically decaying shear viscosity (shear thinning) with increasing shear rate, while the NH method showed discontinuous shear thinning into a string phase, and the AS method produced a continuous increase of viscosity (shear thickening), after a shear thinning region at lower shear rates. Both pairwise additive thermostats are neither purely kinetic nor configurational in definition, and possible directions for further improvement in certain aspects are discussed.

  6. Coupled Nosé-Hoover lattice: A set of the Nosé-Hoover equations with different temperatures

    NASA Astrophysics Data System (ADS)

    Fukuda, Ikuo

    2016-07-01

    A simple scheme was presented to couple any number of the Nosé-Hoover equations with different heat-bath temperatures. In general, several practical procedures can be considered to realize such a coupling, where the system is under nonequilibrium. However, the current scheme provides an equilibrium distribution, namely, a smooth invariant measure for the present system. This is attained by a very simple idea, that is, a force scaling. The current scheme realizes coupled differential equations, analogous to coupled maps. Its theoretical possibilities, mathematical framework, and practical utilities are discussed. Numerical validations applying the method to a simple two-oscillator system are provided.

  7. iNOS signaling interacts with COX-2 pathway in colonic fibroblasts.

    PubMed

    Zhu, Yingting; Zhu, Min; Lance, Peter

    2012-10-01

    COX-2 and iNOS are two major inflammatory mediators implicated in colorectal inflammation and cancer. Previously, the role of colorectal fibroblasts involved in regulation of COX-2 and iNOS expression was largely ignored. In addition, the combined interaction of COX-2 and iNOS signalings and their significance in the progression of colorectal inflammation and cancer within the fibroblasts have received little investigation. To address those issues, we investigated the role of colonic fibroblasts in the regulation of COX-2 and iNOS gene expression, and explored possible mechanisms of interaction between COX-2 and iNOS signalings using a colonic CCD-18Co fibroblast line and LPS, a potential stimulator of COX-2 and iNOS. Our results clearly demonstrated that LPS activated COX-2 gene expression and enhanced PGE(2) production, stimulated iNOS gene expression and promoted NO production in the fibroblasts. Interestingly, activation of COX-2 signaling by LPS was not involved in activation of iNOS signaling, while activation of iNOS signaling by LPS contributed in part to activation of COX-2 signaling. Further analysis indicated that PKC plays a major role in the activation and interaction of COX-2 and iNOS signalings induced by LPS in the fibroblasts.

  8. Expression of inducible nitric oxide synthase (iNOS) in microglia of the developing quail retina.

    PubMed

    Sierra, Ana; Navascués, Julio; Cuadros, Miguel A; Calvente, Ruth; Martín-Oliva, David; Ferrer-Martín, Rosa M; Martín-Estebané, María; Carrasco, María-Carmen; Marín-Teva, José L

    2014-01-01

    Inducible nitric oxide synthase (iNOS), which produce large amounts of nitric oxide (NO), is induced in macrophages and microglia in response to inflammatory mediators such as LPS and cytokines. Although iNOS is mainly expressed by microglia that become activated in different pathological and experimental situations, it was recently reported that undifferentiated amoeboid microglia can also express iNOS during normal development. The aim of this study was to investigate the pattern of iNOS expression in microglial cells during normal development and after their activation with LPS by using the quail retina as model. iNOS expression was analyzed by iNOS immunolabeling, western-blot, and RT-PCR. NO production was determined by using DAR-4M AM, a reliable fluorescent indicator of subcellular NO production by iNOS. Embryonic, postnatal, and adult in situ quail retinas were used to analyze the pattern of iNOS expression in microglial cells during normal development. iNOS expression and NO production in LPS-treated microglial cells were investigated by an in vitro approach based on organotypic cultures of E8 retinas, in which microglial cell behavior is similar to that of the in situ retina, as previously demonstrated in our laboratory. We show here that amoeboid microglia in the quail retina express iNOS during normal development. This expression is stronger in microglial cells migrating tangentially in the vitreal part of the retina and is downregulated, albeit maintained, when microglia differentiate and become ramified. LPS treatment of retina explants also induces changes in the morphology of amoeboid microglia compatible with their activation, increasing their lysosomal compartment and upregulating iNOS expression with a concomitant production of NO. Taken together, our findings demonstrate that immature microglial cells express iNOS during normal development, suggesting a certain degree of activation. Furthermore, LPS treatment induces overactivation of amoeboid

  9. Exercise-induced cardioprotection: a role for eNOS uncoupling and NO metabolites.

    PubMed

    Farah, C; Kleindienst, A; Bolea, G; Meyer, G; Gayrard, S; Geny, B; Obert, P; Cazorla, O; Tanguy, S; Reboul, Cyril

    2013-11-01

    Exercise is an efficient strategy for myocardial protection against ischemia-reperfusion (IR) injury. Although endothelial nitric oxide synthase (eNOS) is phosphorylated and activated during exercise, its role in exercise-induced cardioprotection remains unknown. This study investigated whether modulation of eNOS activation during IR could participate in the exercise-induced cardioprotection against IR injury. Hearts isolated from sedentary or exercised rats (5 weeks training) were perfused with a Langendorff apparatus and IR performed in the presence or absence of NOS inhibitors [N-nitro-L-arginine methyl ester, L-NAME or N5-(1-iminoethyl)-L-ornithine, L-NIO] or tetrahydrobiopterin (BH₄). Exercise training protected hearts against IR injury and this effect was abolished by L-NAME or by L-NIO treatment, indicating that exercise-induced cardioprotection is eNOS dependent. However, a strong reduction of eNOS phosphorylation at Ser1177 (eNOS-PSer1177) and of eNOS coupling during early reperfusion was observed in hearts from exercised rats (which showed higher eNOS-PSer1177 and eNOS dimerization at baseline) in comparison to sedentary rats. Despite eNOS uncoupling, exercised hearts had more S-nitrosylated proteins after early reperfusion and also less nitro-oxidative stress, indexed by lower malondialdehyde content and protein nitrotyrosination compared to sedentary hearts. Moreover, in exercised hearts, stabilization of eNOS dimers by BH4 treatment increased nitro-oxidative stress and then abolished the exercise-induced cardioprotection, indicating that eNOS uncoupling during IR is required for exercise-induced myocardial cardioprotection. Based on these results, we hypothesize that in the hearts of exercised animals, eNOS uncoupling associated with the improved myocardial antioxidant capacity prevents excessive NO synthesis and limits the reaction between NO and O₂·- to form peroxynitrite (ONOO⁻), which is cytotoxic.

  10. Geothermal Heat Pumps for Federal Buildings

    SciTech Connect

    1999-08-01

    OFFICE OF GEOTHERMAL TECHNOLOGIES Geothermal Heat Pumps for Federal Buildings The U.S. Government spends approximately $8 billion annually on its energy needs. To reduce energy use in Federal buildings, President Bill Clinton issued Executive Order 13123 in June 1999, which calls for a 35% reduction in Federal energy use from 1985 levels by 2010. Geothermal heat pumps--when installed in virtually any type of building--can help accomplish this goal with energy savings of up to 40%. Geothermal he.

  11. 77 FR 7597 - Federal Radiological Preparedness Coordinating Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... SECURITY Federal Emergency Management Agency Federal Radiological Preparedness Coordinating Committee AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice of public meeting. SUMMARY: The Federal..., Program Specialist (Emergency Management), DHS/FEMA, 1800 South Bell Street--CC858, Mail Stop...

  12. 2010 Northwest Federal Market Assessment Report

    SciTech Connect

    Scanlon, Tim; Sandusky, William F.

    2011-09-01

    The primary intent of this market assessment is to provide insights on the effectiveness of current energy efficiency and renewable energy program offerings available to Federal sites in the region. The level of detail, quality and currency of the data used in this market assessment varies significantly by Federal agency and energy efficiency service provider. Limited access to some Federal sites, limited availability of key points of contact, time/resource constraints, and other considerations limited the total number of Federal agencies and energy efficiency service providers participating in the survey.

  13. Measuring efficiency among US federal hospitals.

    PubMed

    Harrison, Jeffrey P; Meyer, Sean

    2014-01-01

    This study evaluates the efficiency of federal hospitals, specifically those hospitals administered by the US Department of Veterans Affairs and the US Department of Defense. Hospital executives, health care policymakers, taxpayers, and federal hospital beneficiaries benefit from studies that improve hospital efficiency. This study uses data envelopment analysis to evaluate a panel of 165 federal hospitals in 2007 and 157 of the same hospitals again in 2011. Results indicate that overall efficiency in federal hospitals improved from 81% in 2007 to 86% in 2011. The number of federal hospitals operating on the efficiency frontier decreased slightly from 25 in 2007 to 21 in 2011. The higher efficiency score clearly documents that federal hospitals are becoming more efficient in the management of resources. From a policy perspective, this study highlights the economic importance of encouraging increased efficiency throughout the health care industry. This research examines benchmarking strategies to improve the efficiency of hospital services to federal beneficiaries. Through the use of strategies such as integrated information systems, consolidation of services, transaction-cost economics, and focusing on preventative health care, these organizations have been able to provide quality service while maintaining fiscal responsibility. In addition, the research documented the characteristics of those federal hospitals that were found to be on the Efficiency Frontier. These hospitals serve as benchmarks for less efficient federal hospitals as they develop strategies for improvement.

  14. Federal Technology Transfer Act Success Stories

    EPA Pesticide Factsheets

    Successful Federal Technology Transfer Act (FTTA) partnerships demonstrate the many advantages of technology transfer and collaboration. EPA and partner organizations create valuable and applicable technologies for the marketplace.

  15. Oil Pollution Act (OPA) and Federal Facilities

    EPA Pesticide Factsheets

    The Oil Pollution Prevention regulation sets forth requirements for prevention of, preparedness for, and response to oil discharges at specific non-transportation-related facilities, including federal facilities.

  16. Factors fragmenting the Russian Federation

    SciTech Connect

    Brown, E.

    1993-10-06

    This paper examines the factors that threaten the future of the Russian Federation (RF). The observations are based on a study that focused on eight republics: Mordova, Udmurtia, Tatarstan, Mari El, Bashkortostan, Kabardino-Balkaria, Buryatia, and Altay Republic. These republics were selected for their geographic and economic significance to the RF. Tatarstan, Bashkortostan, Udmurtia, and Mari El are located on important supply routes, such as the Volga River and the trans-Siberian railroad. Some of these republics are relatively wealthy, with natural resources such as oil (e.g., Tatarstan and Bashkortostan), and all eight republics play significant roles in the military-industrial complex. The importance of these republics to the RF contrasts to the relative insignificance of the independence-minded Northern Caucasus area. The author chose not to examine the Northern Caucasus region (except Kabardino-Balkaria) because these republics may have only a minor impact on the rest of the RF if they secede. Their impact would be minimized because they lie on the frontiers of the RF. Many Russians believe that {open_quotes}it might be best to let such a troublesome area secede.{close_quotes}

  17. Nitric oxide synthase (NOS) in the Japanese fireflies Luciola lateralis and Luciola cruciata.

    PubMed

    Ohtsuki, Hajime; Yokoyama, Jun; Ohba, Nobuyoshi; Ohmiya, Yoshihiro; Kawata, Masakado

    2008-12-01

    Species-specific flash patterns in firefly species are important for the investigation of the evolution of Lampyridae. Since nitric oxide synthase (NOS) is one of the key enzymes controlling flash patterns, we determined the cDNA sequences of NOS in the Japanese fireflies Luciola lateralis and L. cruciata. The identity of the NOS sequences was very high between these 2 species. Firefly NOS also exhibited a high identity with those of other insect species, and the cofactor-binding domains were particularly well conserved. Many negatively selected sites were detected throughout the NOS sequences; however, no positive selection was detected. The phylogenetic relationship of insect NOS was different from that of the general classification system, although the lineages corresponded to the major recognized taxonomic groups.

  18. Methylene Blue Attenuates iNOS Induction Through Suppression of Transcriptional Factor Binding Amid iNOS mRNA Transcription.

    PubMed

    Huang, Chao; Tong, Lijuan; Lu, Xu; Wang, Jia; Yao, Wenjuan; Jiang, Bo; Zhang, Wei

    2015-08-01

    Inducible nitric oxide synthase (iNOS) critically contributes to the development of endotoxin-mediated inflammation. It can be induced by cytokines or endotoxins via distinct signaling pathways. Lipopolysaccharide (LPS) triggers iNOS expression through activation of the inhibitor of κB-α (IκB-α)-nuclear factor κB (NF-κB) cascade, whereas interferon-γ (IFN-γ) acts primarily through Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1). Methylene blue (MB), an agent used clinically to treat numerous ailments, has been shown to reduce NO accumulation through suppression of iNOS activity. But it remains unclear whether MB affects iNOS induction. This knowledge gap is addressed in the present study using cultured cells and endotoxemic mice. With mouse macrophages, MB treatment prevented the LPS- and/or IFN-γ-stimulated iNOS protein expression. Real-time PCR experiments showed that iNOS mRNA transcription was robustly blocked by MB treatment. The inhibitory effect of MB on iNOS expression was confirmed in vivo in endotoxemic mice. Further analysis showed that MB had no significant effect on IκB-α degradation and NF-κB or STAT1 phosphorylation in LPS/IFN-γ-stimulated cells. The nuclear transport of active NF-κB or STAT1 was also not affected by MB treatment. But MB treatment markedly reduced the binding of NF-κB and STAT1 to their DNA elements. Chromatin immunoprecipitation assays confirmed that MB reduced NF-κB and STAT1 bindings to iNOS promoter inside the cell. These studies show that MB attenuates transcriptional factor binding amid iNOS mRNA transcription, providing further insight into the molecular mechanism of MB in disease therapy.

  19. Circulating Blood eNOS Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis

    PubMed Central

    Wood, Katherine C.; Cortese-Krott, Miriam M.; Kovacic, Jason C.; Noguchi, Audrey; Liu, Virginia B.; Wang, Xunde; Raghavachari, Nalini; Boehm, Manfred; Kato, Gregory J.; Kelm, Malte; Gladwin, Mark T.

    2013-01-01

    Objective Mice genetically deficient in endothelial nitric oxide synthase (eNOS−/−) are hypertensive with lower circulating nitrite levels, indicating the importance of constitutively produced nitric oxide (NO•) to blood pressure regulation and vascular homeostasis. While the current paradigm holds that this bioactivity derives specifically from expression of eNOS in endothelium, circulating blood cells also express eNOS protein. A functional red cell eNOS that modulates vascular NO• signaling has been proposed. Approach and Results To test the hypothesis that blood cells contribute to mammalian blood pressure regulation via eNOS-dependent NO• generation, we cross-transplanted WT and eNOS−/− mice, producing chimeras competent or deficient for eNOS expression in circulating blood cells. Surprisingly, we observed a significant contribution of both endothelial and circulating blood cell eNOS to blood pressure and systemic nitrite levels, the latter being a major component of the circulating NO• reservoir. These effects were abolished by the NOS inhibitor L-NAME and repristinated by the NOS substrate L-Arginine, and were independent of platelet or leukocyte depletion. Mouse erythrocytes were also found to carry an eNOS protein and convert 14C-Arginine into 14C-Citrulline in a NOS-dependent fashion. Conclusions These are the first studies to definitively establish a role for a blood borne eNOS, using cross transplant chimera models, that contributes to the regulation of blood pressure and nitrite homeostasis. This work provides evidence suggesting that erythrocyte eNOS may mediate this effect. PMID:23702660

  20. Federal Pioneers: Environmentally Preferable Purchasing Success Stories from the Federal Government

    EPA Pesticide Factsheets

    The federal government purchases more than $200 billion worth of goods and services each year; purchasing decisions can have important environmental consequences, federal agencies are considering some environmental impacts when buying goods and services.

  1. 40 CFR 49.9990 - Federally-promulgated regulations and Federal implementation plans.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Umpqua and Siuslaw Indians of Oregon § 49.9990 Federally-promulgated regulations and Federal... Reservation of the Confederated Tribes of the Coos, Lower Umpqua and Siuslaw Indians: (a) Section...

  2. 40 CFR 49.9990 - Federally-promulgated regulations and Federal implementation plans.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Umpqua and Siuslaw Indians of Oregon § 49.9990 Federally-promulgated regulations and Federal... Reservation of the Confederated Tribes of the Coos, Lower Umpqua and Siuslaw Indians: (a) Section...

  3. 40 CFR 49.9990 - Federally-promulgated regulations and Federal implementation plans.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Umpqua and Siuslaw Indians of Oregon § 49.9990 Federally-promulgated regulations and Federal... Reservation of the Confederated Tribes of the Coos, Lower Umpqua and Siuslaw Indians: (a) Section...

  4. 76 FR 35966 - Federal Agricultural Mortgage Corporation Governance and Federal Agricultural Mortgage...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... From the Federal Register Online via the Government Publishing Office FARM CREDIT ADMINISTRATION... Federal Agricultural Mortgage Corporation Funding and Fiscal Affairs; Risk- Based Capital Requirements; Effective Date AGENCY: Farm Credit Administration. ACTION: Notice of effective date. SUMMARY: The...

  5. 78 FR 70482 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-71; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Chapter 1 Federal Acquisition Regulation; Federal Acquisition Circular 2005-71; Small Entity Compliance Guide AGENCY: Department of Defense (DoD), General Services Administration (GSA), and National Aeronautics and...

  6. Federal Funding Opportunities to Support the P-20W Data Pipeline. Federal Spotlight

    ERIC Educational Resources Information Center

    Data Quality Campaign, 2014

    2014-01-01

    This publication provides an overview of the current federal opportunities to help states advance their data-related activities. Although not exhaustive, this list provides a starting point for federal policymakers to support states' work in this area.

  7. 77 FR 13951 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-57; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ...; Introduction; United States-Korea Free Trade Agreement; Small Entity Compliance Guide; Final Rules #0;#0... Chapter 1 Federal Acquisition Regulation; Federal Acquisition Circular 2005-57; Introduction...

  8. 75 FR 19167 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-41; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... Federal Acquisition Regulations; Federal Acquisition Circular 2005-41; Introduction; FAR Case 2009-005... Acquisition Circular 2005-41; Introduction AGENCIES: Department of Defense (DoD), General...

  9. 77 FR 35393 - Federal Management Regulation; FMR Bulletin PBS-2012-03; Redesignations of Federal Buildings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... ADMINISTRATION Federal Management Regulation; FMR Bulletin PBS-2012-03; Redesignations of Federal Buildings AGENCY: Public Buildings Service (PBS), General Services Administration (GSA). ACTION: Notice of a... buildings. Expiration Date: This bulletin announcement expires October 31, 2012. The building...

  10. Federation of Malaysia. Country profile.

    PubMed

    Newcomb, L

    1985-01-01

    The 1984 population of Malaysia has been estimated at 14.7 million and the population growth rate averaged 2.3% in 1970-80. Population growth is officially encouraged to form a substantial home market for economic development. Toward this end, the 1985 budget has increased tax deductions for families with 5 children. The capital city of Kuala Lumpur is the largest metropolitan area (1 million population) and the Federal Territory is the most densely populated region. Immigration is strictly controlled by the government, and the percentage of foreign-born citizens was 5% in 1980. China, India, and Pakistan are decreasing in importance as countries of origin. Internal mobility, however, is increasing. Rural-rural migration accounted for 45% of internal migration in 1970-80 and was largely motivated by family reasons. Only 7% of Malaysians are estimated to move in search of work. Racial tensions led the government to grant special economic privileges to native-born Islamic Malays. The greatest proportion of the population is centered in the lowest age groups. The percentage of females 15-29 years of age rose from 26% in 1970 to 30% in 1980 and is expected to continue to rise. Fertility is on the decline. The majority of households in the country involve nuclear families. There has been an increase in the number of men and women who delay marriage or remain single. Education is widely available for children aged 6-15 years and those who meet certain academic standards receive free education up to age 19 years. The current labor force is estimated at 5.4 million, with an annual growth rate of 3.1%. Malaysia's per capita income (US $1860 in 1982) is among the highest in Southeast Asia and the gross national product increased by an average annual rate of 8% in 1970-81. The government plans to move toward the development of heavier industries and more manufacturing concerns.

  11. Discussion Forum: Federal Records and Archives.

    ERIC Educational Resources Information Center

    Bradsher, James Gregory

    1987-01-01

    Introduces various topics relating to federal records and archives, including descriptions of federal records, permanent records, and archives; responsibility for the creation and maintenance of these items; the policy for deciding which records become archives; and legal issues relating to records and access to them. (Author/CLB)

  12. POLLUTION PREVENTION RESEARCH WITHIN THE FEDERAL COMMUNITY

    EPA Science Inventory

    One of the primary ongoing programs for promotion and encouragement of pollution prevention research is a cooperative program between the U.S. Environmental Protection Agency (EPA) and the Federal community at large. EPA’s Waste Reduction Evaluations At Federal Sites (WREAFS) Pro...

  13. POLLUTION RESEARCH WITHIN THE FEDERAL COMMUNITY

    EPA Science Inventory

    This project summary describes the U.S. Environmental Protection Agency (EPA) Waste Reduction Evaluations at Federal Sites (WREAFS) program to support pollution prevention (P2) research throughout the Federal community, and the current status on all projects as of September 1994...

  14. 40 CFR 72.4 - Federal authority.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Federal authority. 72.4 Section 72.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.4 Federal authority. (a) The Administrator reserves...

  15. 40 CFR 72.4 - Federal authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Federal authority. 72.4 Section 72.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.4 Federal authority. (a) The Administrator reserves...

  16. 40 CFR 72.4 - Federal authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Federal authority. 72.4 Section 72.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.4 Federal authority. (a) The Administrator reserves...

  17. 40 CFR 72.4 - Federal authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Federal authority. 72.4 Section 72.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.4 Federal authority. (a) The Administrator reserves...

  18. 40 CFR 72.4 - Federal authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Federal authority. 72.4 Section 72.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.4 Federal authority. (a) The Administrator reserves...

  19. 76 FR 76899 - Federal Acquisition Regulation; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ...; Correction; FAR Case 2011-014; Docket 2011-0014; Sequence 1] RIN 9000-AM11 Federal Acquisition Regulation; Correction AGENCIES: Department of Defense (DoD), General Services Administration (GSA), and National... corrections to the final rule which was published in the Federal Register of Wednesday, November 2, 2011...

  20. 76 FR 40944 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of July 11, 18, 25, August 1, 8, 15, 2011. PLACE: Commissioners' Conference Room, 11555...

  1. 75 FR 76055 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Date: Weeks of December 6, 13, 20, 27, 2010, January 3, 10, 2011. Place: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public...

  2. 76 FR 81542 - Sunshine Federal Register

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-28

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of December 26, 2011, January 2, 9, 16, 23, 30, 2012. PLACE: Commissioners' Conference Room,...

  3. 78 FR 32280 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. DATE: Weeks of May 27, June 3, 10, 17, 24, July 1, 2013. PLACE: Commissioners' Conference Room,...

  4. 76 FR 21782 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Weeks of April 18, 25; May 2, 9, 16, 23, 30; June 6, 13, 2011. PLACE: Commissioners' Conference...

  5. 75 FR 52047 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Weeks of August 23, 30, and September 6, 13, 20, 27, 2010. Place: Commissioners' Conference Room,...

  6. 76 FR 30205 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of May 23, 30, June 6, 13, 20, 27, 2011. PLACE: Commissioners' Conference Room, 11555...

  7. 75 FR 33855 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Weeks of June 14, 21, 28, July 5, 12, 19, 2010. PLACE: Commissioners' Conference Room, 11555...

  8. 75 FR 37478 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding The Meetings: Nuclear Regulatory Commission. Date: Weeks of June 28, July 5, 12, 19, 26, August 2, 2010. Place: Commissioners' Conference Room,...

  9. 76 FR 78952 - Sunshine Federal Register; Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register; Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC-2011- 0006]. DATE: Weeks of December 19, 26, 2011, January 2, 9, 16, 23, 2012. PLACE:...

  10. 75 FR 29369 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. DATES: Weeks of May 24, 31, June, 7, 14, 21, 28, 2010. Place: Commissioners' Conference Room, 11555...

  11. 77 FR 73694 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... [Federal Register Volume 77, Number 238 (Tuesday, December 11, 2012)] [Notices] [Page 73694] [FR Doc No: 2012-29954] NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission [NRC-2012- 0002]. DATES: Weeks of December 10, 17, 24, 31,...

  12. 76 FR 17460 - SUNSHINE FEDERAL REGISTER NOTICE

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-29

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION SUNSHINE FEDERAL REGISTER NOTICE AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission DATES: Weeks of March 28, April 4, 11, 18, 25, May 2, 9, 16, 23, 30, June 6, 13, 2011. PLACE:...

  13. 75 FR 23822 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice DATES: Weeks of May 3, 10, 17, 24, 31, June 7, 2010. Place: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and closed. Week...

  14. 76 FR 20385 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of April 11, 18, 25, May 2, 9, 16, 23, 30, June 6, 13, 2011. PLACE: Commissioners' Conference...

  15. 76 FR 55424 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency holding the meetings: Nuclear Regulatory Commission. Date: Weeks of September 5, 12, 19, 26, and October 3, 10, 2011. Place: Commissioners' Conference Room,...

  16. 75 FR 17452 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. Dates: Weeks of April 5, 12, 19, 26, May 3, 10, 2010. Place: Commissioners' Conference Room, 11555...

  17. 78 FR 25320 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission [NRC-2013- 0001]. DATES: Weeks of April 29, May 6, 13, 20, 27, June 3, 2013. PLACE:...

  18. 75 FR 68840 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... [Federal Register Volume 75, Number 216 (Tuesday, November 9, 2010)] [Notices] [Page 68840] [FR Doc No: 2010-28393] NUCLEAR REGULATORY COMMISSION [NRC-2010-0002] Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. Dates: Weeks of November 8, 15, 22,...

  19. 75 FR 39991 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of July 12, 19, 26, August 2, 9, 16, 2010. PLACE: Commissioners' Conference Room, 11555...

  20. 76 FR 36161 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Weeks of June 20, 27, July 4, 11, 18, 25, 2011. PLACE: Commissioners' Conference Room, 11555...

  1. 76 FR 16016 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC-2011- 0006]. DATE: Weeks of March 21, 28, April 4, 11, 18, 25, 2011. PLACE: Commissioners'...

  2. 77 FR 3513 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... [Federal Register Volume 77, Number 15 (Tuesday, January 24, 2012)] [Notices] [Pages 3513-3514] [FR Doc No: 2012-1526] NUCLEAR REGULATORY COMMISSION [NRC-2012-0002] Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. [[Page 3514

  3. 76 FR 42751 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of July 18, 25, August 1, 8, 15, 22, 2011. PLACE: Commissioners' Conference Room, 11555...

  4. 78 FR 35071 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission [NRC-2013- 0001] DATES: Weeks of June 10, 17, 24, July 1, 8, 15, 2013. PLACE: Commissioners' Conference...

  5. 75 FR 82094 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... [Federal Register Volume 75, Number 249 (Wednesday, December 29, 2010)] [Notices] [Pages 82094-82095] [FR Doc No: 2010-32921] NUCLEAR REGULATORY COMMISSION [NRC-2010-0002] Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of December 27,...

  6. 77 FR 62539 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission [NRC-2012- 0002]. DATE: Weeks of October 8, 15, 22, 29, November 5, 12, 19, 2012. PLACE:...

  7. 76 FR 11290 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATES: Weeks of February 28, March 7, 14, 21, 28, April 4, 2011. PLACE: Commissioners' Conference Room,...

  8. 76 FR 23341 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of April 25, May 2, 9, 16, 23, 30, June 6, 13, 2011. PLACE: Commissioners' Conference Room,...

  9. 76 FR 58312 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of September 19, 26, and October 3, 10, 17, 24, 2011. PLACE: Commissioners' Conference Room,...

  10. 75 FR 45679 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission [NRC-2010- 0002]. DATE: Weeks of August 2, 9, 16, 23, 30, and September 6, 2010. PLACE:...

  11. 75 FR 26293 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. DATES: Weeks of May 10, 17, 24, 31, June, 7, 14, 2010. Place: Commissioners' Conference Room, 11555...

  12. 75 FR 18907 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission [NRC-2010- 0002] DATE: Weeks of April 12, 19, 26, May 3, 10, 17, 2010. PLACE: Commissioners' Conference...

  13. 76 FR 18809 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of April 4, 11, 18, 25, May 2, 9, 16, 23, 30, June 6, 13, 2011. PLACE: Commissioners'...

  14. 77 FR 20077 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-03

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of April 2, 9, 16, 23, 30, May 7, 2012. PLACE: Commissioners' Conference Room, 11555...

  15. 76 FR 24933 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of May 2, 9, 16, 23, 30, June 6, 13, 2011. PLACE: Commissioners' Conference Room, 11555...

  16. 75 FR 30865 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. DATES: Weeks of May 31, June, 7, 14, 21, 28, July 5, 2010. Place: Commissioners' Conference Room,...

  17. 75 FR 48381 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of August 9, 16, 23, 30, and September 6, 13, 2010. PLACE: Commissioners' Conference Room,...

  18. 77 FR 4839 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission [NRC-2012- 0002]. DATES: Weeks of January 30, February 6, 13, 20, 27, March 5, 2012. Place:...

  19. 76 FR 53980 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of August 29, September 5, 12, 19, 26, and October 3, 2011. PLACE: Commissioners' Conference...

  20. 78 FR 48203 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... [Federal Register Volume 78, Number 152 (Wednesday, August 7, 2013)] [Notices] [Pages 48203-48204] [FR Doc No: 2013-19171] NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission [NRC-2013- 0001]. DATES: Week of August 5, 2013....

  1. 76 FR 76199 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of December 5, 12, 19, 26, 2011, January 2, 9, 2012. PLACE: Commissioners' Conference Room,...

  2. 77 FR 27099 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-08

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC-2012- 0002]. DATE: Weeks of May 7, 14, 21, 28, June 4, 11, 2012. PLACE: Commissioners' Conference...

  3. 76 FR 37853 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission [NRC-2011- 0006]. DATE: Weeks of June 27, July 4, 11, 18, 25, August 1, 2011. PLACE:...

  4. 75 FR 39057 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. Date: Weeks of July 5, 12, 19, 26, August 2, 9, 2010. Place: Commissioners' Conference Room, 11555...

  5. 76 FR 5626 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. DATE: Weeks of January 31, February 7, 14, 21, 28, March 7, 2011. PLACE: Commissioners' Conference Room,...

  6. 76 FR 63329 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... [Federal Register Volume 76, Number 197 (Wednesday, October 12, 2011)] [Notices] [Pages 63329-63330] [FR Doc No: 2011-26461] NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC-2011- 0006]. DATES: Weeks of October 10, 17,...

  7. 75 FR 13800 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. DATES: Weeks of March 22, 29, April 5, 12, 19, 26, 2010. Place: Commissioners' Conference Room, 11555...

  8. 76 FR 14107 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-15

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission. [NRC-2011- 0006]. DATE: Weeks of March 14, 21, 28, April 4, 11, 18, 2011. PLACE: Commissioners'...

  9. 75 FR 22166 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice Agency Holding the Meetings: Nuclear Regulatory Commission. DATES: Weeks of April 26, May 3, 10, 17, 24, 31, 2010. Place: Commissioners' Conference Room, 11555...

  10. Federal Permitting Improvement Act of 2013

    THOMAS, 113th Congress

    Sen. Portman, Rob [R-OH

    2013-07-30

    03/11/2014 Committee on Homeland Security and Governmental Affairs Subcommittee on the Efficiency and Effectiveness of Federal Programs and the Federal Workforce. Hearings held. With printed Hearing: S.Hrg. 113-371. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  11. 42 CFR 38.9 - Federal audits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Federal audits. 38.9 Section 38.9 Public Health... ASSISTANCE FOR CRISIS COUNSELING AND TRAINING § 38.9 Federal audits. The Secretary, the Administrator, and... supplies received under this part for the purpose of audit and examination....

  12. 77 FR 74543 - Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... ADMINISTRATION National Women's Business Council Federal Advisory Committee Meeting AGENCY: U.S. Small Business Administration. ACTION: Notice of open Federal advisory committee meeting. ] SUMMARY: The SBA is issuing this... Business Council (NWBC). The meeting will be open to the public. DATES: The meeting will be held on...

  13. Federal Register Document Image Database, Volume 1

    National Institute of Standards and Technology Data Gateway

    NIST Federal Register Document Image Database, Volume 1 (PC database for purchase)   NIST has produced a new document image database for evaluating document analysis and recognition technologies and information retrieval systems. NIST Special Database 25 contains page images from the 1994 Federal Register and much more.

  14. 13 CFR 314.2 - Federal Interest.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Federal Interest. 314.2 Section 314.2 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE PROPERTY General § 314.2 Federal Interest. (a) Property that is acquired or improved, in whole or in...

  15. 78 FR 61404 - Federal Salary Council; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... MANAGEMENT Federal Salary Council; Meeting AGENCY: Office of Personnel Management. ACTION: Notice of meeting. SUMMARY: The Federal Salary Council will meet on November 5, 2013, at the time and location shown below... or modification of locality pay areas, the coverage of salary surveys, the process of...

  16. 75 FR 68010 - Federal Salary Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... Doc No: 2010-27835] OFFICE OF PERSONNEL MANAGEMENT Federal Salary Council AGENCY: Office of Personnel Management. ACTION: Notice of meeting. SUMMARY: The Federal Salary Council will meet on November 19, 2010, at... recommendations cover the establishment or modification of locality pay areas, the coverage of salary surveys,...

  17. 75 FR 63215 - Federal Salary Council Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... MANAGEMENT Federal Salary Council Meeting AGENCY: Office of Personnel Management. ACTION: Notice of Meeting. SUMMARY: The Federal Salary Council will meet on October 29, 2010, at the time and location shown below... or modification of locality pay areas, the coverage of salary surveys, the process of...

  18. 76 FR 59175 - Federal Salary Council; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... MANAGEMENT Federal Salary Council; Meeting AGENCY: Office of Personnel Management. ACTION: Notice of meeting. SUMMARY: The Federal Salary Council will meet on November 4, 2011, at the time and location shown below... or modification of locality pay areas, the coverage of salary surveys, the process of...

  19. Cable Television: A Guide to Federal Regulations.

    ERIC Educational Resources Information Center

    Rivkin, Steven R.

    The federal laws and regulations that presently apply to cable television are comprehensively discussed in this lengthy report. The report has been designed as a guide and reference book for state and local officials, cable operators, and citizen groups. It presents a complete discussion of the 1972 Federal Communications Commission's (FCC) Report…

  20. Federal Offenders Rehabilitation Collaboration Research Program.

    ERIC Educational Resources Information Center

    1964

    This paper gives the specifics of a federal offenders rehabilitation program implementation and evaluation which will test and demonstrate the effects of providing intensive vocational rehabilitation services to federal offenders. The authors note that criminal offenders have difficulty in vocational adjustment, and this is exacerbated by their…

  1. School Federation Governing: Translation or Transformation

    ERIC Educational Resources Information Center

    Baxter, Jacqueline; Wise, Christine

    2013-01-01

    This article examines the ways in which being a member of a federation governing body impacts upon the governor identities of individuals. Using an ideographic case study based upon a single academy federation, the investigation employs a framework for identity analysis to analyse qualitative in-depth interviews with members within governing…

  2. Federal Grants to State and Local Governments

    ERIC Educational Resources Information Center

    Congressional Budget Office, 2013

    2013-01-01

    In fiscal year 2011, the federal government provided $607 billion in grants to state and local governments. Those funds accounted for 17 percent of federal outlays, 4 percent of gross domestic product (GDP), and a quarter of spending by state and local governments that year. Over the past 30 years, those "intergovernmental" grants--financial…

  3. 75 FR 12809 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... Federal Aviation Administration Notice of Intent To Rule on Request To Release Airport Property at the Dallas/Fort Worth International Airport, DFW Airport, Texas AGENCY: Federal Aviation Administration (FAA... provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st Century (AIR...

  4. 42 CFR 38.9 - Federal audits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Federal audits. 38.9 Section 38.9 Public Health... ASSISTANCE FOR CRISIS COUNSELING AND TRAINING § 38.9 Federal audits. The Secretary, the Administrator, and... supplies received under this part for the purpose of audit and examination....

  5. 23 CFR 777.5 - Federal participation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... IMPACTS TO WETLANDS AND NATURAL HABITAT § 777.5 Federal participation. (a) Those measures which the FHWA... and natural habitats are eligible for Federal participation where the impacts are the result of..., monitoring, and establishment of wetlands and natural habitat mitigation projects, and acquisition of land...

  6. 23 CFR 777.5 - Federal participation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... IMPACTS TO WETLANDS AND NATURAL HABITAT § 777.5 Federal participation. (a) Those measures which the FHWA... and natural habitats are eligible for Federal participation where the impacts are the result of..., monitoring, and establishment of wetlands and natural habitat mitigation projects, and acquisition of land...

  7. 23 CFR 777.5 - Federal participation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... IMPACTS TO WETLANDS AND NATURAL HABITAT § 777.5 Federal participation. (a) Those measures which the FHWA... and natural habitats are eligible for Federal participation where the impacts are the result of..., monitoring, and establishment of wetlands and natural habitat mitigation projects, and acquisition of land...

  8. 23 CFR 777.5 - Federal participation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... IMPACTS TO WETLANDS AND NATURAL HABITAT § 777.5 Federal participation. (a) Those measures which the FHWA... and natural habitats are eligible for Federal participation where the impacts are the result of..., monitoring, and establishment of wetlands and natural habitat mitigation projects, and acquisition of land...

  9. 23 CFR 777.5 - Federal participation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... IMPACTS TO WETLANDS AND NATURAL HABITAT § 777.5 Federal participation. (a) Those measures which the FHWA... and natural habitats are eligible for Federal participation where the impacts are the result of..., monitoring, and establishment of wetlands and natural habitat mitigation projects, and acquisition of land...

  10. Federal Grants and National Educational Policy.

    ERIC Educational Resources Information Center

    Levin, H. M.; Tsang, Mun C.

    The impact of and justification for using federal grants to carry out national policies in education is explored in this document. The paper opens by noting that the locally-made decisions typical of our federal system of government do not always take into account such national interests as those in increasing equality of opportunity, providing…

  11. A Guide to Federal Reserve Regulations.

    ERIC Educational Resources Information Center

    Federal Reserve Bank of New York, NY.

    The Board of Governors of the Federal Reserve System and the Federal Reserve Banks administer more than two dozen regulations affecting a wide variety of financial activities. The regulations concern the functions of the central bank and its relationships with financial institutions, the activities of commercial banks and bank holding companies,…

  12. Federal Policy Barriers to Assistive Technology.

    ERIC Educational Resources Information Center

    National Council on Disability, Washington, DC.

    This report identifies barriers in federal assistive technology (AT) policy to increasing the availability of and access to assistive technology devices and assistive technology services for people with disabilities. The report is the result of a review of the professional literature, a review of federal policies and two stakeholder surveys, one…

  13. 23 CFR 752.11 - Federal participation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... least one-quarter of one percent of funds expended for such landscaping project is used to plant native... (b) of this section, Federal-aid highway funds may participate in plant establishment periods in or..., Federal-aid highway funds may participate in the planting of flowering materials, including...

  14. Federal Treaty Responsibility for Indian Education.

    ERIC Educational Resources Information Center

    Deloria, Vine, Jr.

    In view of prior treaties and recent laws, American Indian affairs seem to fluctuate between two different problems--the extent of Federal control "over" Indians and the extent of Federal responsibility "to" Indians. Since treaty interpretations often come years after ratification, it is necessary that a treaty be liberally construed to the end…

  15. Congress Creates Super Federal Library Agency

    ERIC Educational Resources Information Center

    Steere, Paul J.

    2010-01-01

    In a rare show of bipartisanship, the Senate passed the controversial Federal Library Agency Act (FLAA) on a nearly unanimous voice vote, sending it to President Obama for his expected signature. The House had passed it in February with a two-thirds majority. The FLAA creates a new mandate by combining federal library functions scattered…

  16. Federal Participation in LEED in 2005

    SciTech Connect

    Payne, Christopher; Dyer, Beverly

    2005-11-01

    The federal government is an active participant in promotingsustainable design, construction and operations and in the use of USGBC'sLeadership in Energy and Environmental Design (LEED) Green BuildingRating System. This paper presents an overview of sustainableconstruction activities in the federal sector in 2005.

  17. Teaching Litigation with the Federal Government.

    ERIC Educational Resources Information Center

    Sisk, Gregory C.

    1999-01-01

    Describes a course on civil litigation with the federal government at Drake University Law School (Iowa). Notes course objectives, including the practical aspects of federal government civil litigation, the concept of sovereign immunity in a democratic society, theories of statutory interpretation, and use of attorney fee shifting in such cases.…

  18. 78 FR 54680 - NASA Federal Advisory Committees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... SPACE ADMINISTRATION NASA Federal Advisory Committees AGENCY: National Aeronautics and Space Administration. ACTION: Annual Invitation for Public Nominations by U.S. Citizens for Service on NASA Federal Advisory Committees. SUMMARY: NASA announces its annual invitation for public nominations for service...

  19. 7 CFR 1260.112 - Federation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Promotion and Research Order Definitions § 1260.112 Federation. Federation means the Beef Industry Council of the National Live Stock and Meat Board, or any successor organization to the Beef Industry...

  20. Indian Giving: Federal Programs for Native Americans.

    ERIC Educational Resources Information Center

    Levitan, Sar A.; Johnston, William B.

    Aimed at highlighting American Indian reservation conditions, outlining the scope of Federal aid to Indians, and suggesting the nature of future Indian problems and choices, this book attempts to assess the current socioeconomic status of the Indian community and its relationship with the Federal Government. Specifically, this book provides both…

  1. 20 CFR 658.424 - Federal hearings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Federal hearings. 658.424 Section 658.424 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) ADMINISTRATIVE PROVISIONS GOVERNING THE JOB SERVICE SYSTEM Job Service Complaint System Federal Js Complaint System §...

  2. 78 FR 13099 - Sunshine Federal Register Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Federal Register Notice AGENCY HOLDING THE MEETINGS: Nuclear Regulatory Commission, [NRC... 2, 2013 9:30 a.m. Meeting With Organization of Agreement States (OAS) and Conference of...

  3. [Genetics of the neuronal NO synthase (NOS1) in the etiology of bronchial asthma].

    PubMed

    Grasemann, H

    2001-08-01

    The free radical nitric oxide (NO) is endogenously produced by enzymes known as NO synthases. NO in the airways is involved in a number of pathophysiological processes, such as airway inflammation, allergic reactions, and asthma. Asthma is a multifactorial disease that is caused by environmental and genetic factors. Genome wide screening approaches in families revealed evidence for linkage between chromosomal region 12q and allergic diseases, increased serum IgE levels as well as the development of asthma. The gene encoding for neuronal NOS (NOS1) is an attractive candidate gene for asthma, not only because it is localized in chromosomal region 12q24. Experimental studies in animals and humans suggest that NOS1 plays an important role in asthma. For instance, in a murine model of allergic asthma, NOS1 has been shown to be important for the development of bronchial hyperresponsiveness, since mice deficient for the nos1 gene were less responsive to airway challenge than both wild-type mice and mice deficient for the nos2 gene. Case-control studies in humans revealed allelic associations between polymorphic markers in the NOS1 gene and the diagnosis of asthma. Furthermore, increased concentrations of NO in the airways of asthmatics are closely related to the size of an intronic (AAT)(n)-repeat polymorphism in the NOS1 gene. The purpose of this review is to summarize studies that provide evidence for an involvement of NOS1 in the genetics of asthma.

  4. Inhibition of Rho protein stimulates iNOS expression in rat vascular smooth muscle cells.

    PubMed

    Muniyappa, R; Xu, R; Ram, J L; Sowers, J R

    2000-06-01

    Inducible nitric oxide synthase (iNOS) in vascular smooth muscle cells (VSMCs) is upregulated in arterial injury and plays a role in regulating VSMC proliferation and restenosis. Inflammatory cytokines [e.g., interleukin-1beta (IL-1beta)] released during vascular injury induce iNOS. Small GTP-binding proteins of the Ras superfamily play a major role in IL-1beta-dependent signaling pathways. In this study, we examined the role of Rho GTPases in regulating iNOS expression in VSMCs. Treatment of VSMCs with mevastatin, which inhibits isoprenylation of Rho and other small GTP-binding proteins, produced significantly higher amounts of IL-1beta-evoked NO and iNOS protein compared with control. Similarly, bacterial toxins [Toxin B from Clostridium difficile and C3 ADP-ribosyl transferase (C3) toxin from Clostridium botulinium] that specifically inactivate Rho proteins increased NOS products (NO and citrulline) and iNOS expression. Toxin B increased the activity of iNOS promoter-reporter construct in VSMCs. Both toxins enhanced IL-1beta-stimulated iNOS expression and NO production. These data demonstrate for the first time that inhibition of Rho induces iNOS and suggest a role for Rho protein in IL-1beta-stimulated NO production in VSMCs.

  5. Evaluation of a multi-functional nanocarrier for targeted breast cancer iNOS gene therapy.

    PubMed

    McCarthy, Helen O; Zholobenko, Alek V; Wang, Yuhua; Canine, Brenda; Robson, Tracy; Hirst, David G; Hatefi, Arash

    2011-02-28

    The present study determines whether the novel designer biomimetic vector (DBV) can condense and deliver the cytotoxic iNOS gene to breast cancer cells to achieve a therapeutic effect. We have previously shown the benefits of iNOS for cancer gene therapy but the stumbling block to future development has been the delivery system. The DBV was expressed, purified and complexed with the iNOS gene. The particle size and charge were determined via dynamic light scattering techniques. The toxicity of the DBV/iNOS nanoparticles was quantified using the cell toxicity and clonogenic assays. Over expression of iNOS was confirmed via Western blotting and Griess test. The DBV delivery system fully condensed the iNOS gene with nanoparticles less than 100nm. Transfection with the DBV/iNOS nanoparticles resulted in a maximum of 62% cell killing and less than 20% clonogenicity. INOS overexpression was confirmed and total nitrite levels were in the range of 18μM. We report for the first time that the DBV can successfully deliver iNOS and achieve a therapeutic effect. There is significant cytotoxicity coupled with evidence of a bystander effect. We conclude that the success of the DBV fusion protein in the delivery of iNOS in vitro is worthy of future in vivo experiments.

  6. PEX7 and EBP50 Target iNOS to the Peroxisome in Hepatocytes

    PubMed Central

    Loughran, Patricia A.; Stolz, Donna B.; Barrick, Stacey R.; Wheeler, David S.; Friedman, Peter A.; Rachubinski, Richard A.; Watkins, Simon C.; Billiar, Timothy R.

    2013-01-01

    iNOS localizes to both the cytosol and peroxisomes in hepatocytes in vitro and in vivo. The structural determinants for iNOS localization are not known. One plausible mechanism for iNOS localization to the peroxisome is through the interaction with peroxisomal import proteins PEX5 or PEX7. siRNA knockdown of PEX7 reduced iNOS colocalization with the peroxisomal protein PMP70. Proteomic studies using MALDI-MS identified iNOS association with the 50-kD ezrin binding PDZ protein (EBP50). Confocal microscopy studies and immunoelectron microscopy confirmed iNOS association with EBP50, with greatest colocalization occurring at 8 hours of cytokine exposure. EBP50 associated with peroxisomes in a PEX5 and PEX7-dependent manner. iNOS localization to peroxisomes was contingent on EBP50 expression in LPS-treated mice. Thus, iNOS targeting to peroxisomes in hepatocytes involves interaction with PEX7 and EBP50. The targeting of iNOS protein to the peroxisome may shift the balance of metabolic processes that rely on heme proteins susceptible to modification by radical oxygen and nitrogen radicals. PMID:23474170

  7. Federal coal leasing proposed rules published

    SciTech Connect

    Not Available

    1981-12-30

    Proposed rules by the Bureau of Land Management (BLM) and the US Geological Survey (USGS) are designed to streamline the existing federal coal leasing rules and ultimately accelerate the offering of publicly-owned coal lands, according to an announcement by Interior Secretary James Watt. The rules were published in the December 16, 1981 federal Register. The BLM and the USGS proposed rules (which appear in the Code of Federal Regulations, Group 3400 of Title 43 and Part 211 of Title 30, respectively) are coordinated and cross-referenced to serve as a total revision of the Federal coal leasing program. The proposed rules maintain the existing structure of the Federal coal management program, but make several important modifications that strengthen the program and add needed flexibility.

  8. Report of the Federal Internetworking Requirements Panel

    SciTech Connect

    1994-05-31

    The Federal Internetworking Requirements Panel (FIRP) was established by the National Institute of Standards and Technology (NIST) to reassess Federal requirements for open systems networks and to recommend policy on the Government`s use of networking standards. The Panel was chartered to recommend actions which the Federal Government can take to address the short and long-term issues of interworking and convergence of networking protocols--particularly the Internet Protocol Suite (IPS) and Open Systems Interconnection (OSI) protocol suite and, when appropriate, proprietary protocols. The Panel was created at the request of the Office of Management and Budget in collaboration with the Federal Networking Council and the Federal Information Resources Management Policy Council. The Panel`s membership and charter are contained in an appendix to this report.

  9. 75 FR 24375 - Participation by Federal Candidates and Officeholders at Non-Federal Fundraising Events

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... Federal candidates and officeholders are permitted to ``attend, speak, or be a featured guest at a... have allowed Federal candidates and officeholders only to attend, speak, or be a featured guest at..., its reference to ``featured guests''-- affected the role that Federal candidates and...

  10. 44 CFR Appendix A to Part 62 - Federal Emergency Management Agency, Federal Insurance Administration, Financial Assistance...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Agency, Federal Insurance Administration, Financial Assistance/Subsidy Arrangement A Appendix A to Part... OF CLAIMS Pt. 62, App. A Appendix A to Part 62—Federal Emergency Management Agency, Federal Insurance... insurance using the Standard Flood Insurance Policy. Accounting Data: Pursuant to Section 1310 of the Act,...

  11. 77 FR 38784 - Notice of Proposed Information Collection Requests; Federal Student Aid; Federal Perkins Loan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Notice of Proposed Information Collection Requests; Federal Student Aid; Federal Perkins Loan Program..., formerly the National Direct/Defense Student Loan Program (NDSL), currently use this form to...

  12. 78 FR 65767 - Student Assistance General Provisions, Federal Perkins Loan Program, Federal Family Education...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ...The Secretary amends the Student Assistance General Provisions, Federal Perkins Loan (Perkins Loan) Program, Federal Family Education Loan (FFEL) Program, and William D. Ford Federal Direct Loan (Direct Loan) Program regulations. These final regulations will: Amend the FFEL and Direct Loan program regulations to reflect changes made to the Higher Education Act of 1965, as amended (HEA), by the......

  13. 34 CFR 682.501 - Extent of Federal guarantee under the Federal GSL programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Extent of Federal guarantee under the Federal GSL programs. 682.501 Section 682.501 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN...

  14. 34 CFR 682.501 - Extent of Federal guarantee under the Federal GSL programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 4 2012-07-01 2012-07-01 false Extent of Federal guarantee under the Federal GSL programs. 682.501 Section 682.501 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) FEDERAL FAMILY...

  15. 34 CFR 682.501 - Extent of Federal guarantee under the Federal GSL programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 4 2013-07-01 2013-07-01 false Extent of Federal guarantee under the Federal GSL programs. 682.501 Section 682.501 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) FEDERAL FAMILY...

  16. 34 CFR 682.501 - Extent of Federal guarantee under the Federal GSL programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 4 2011-07-01 2011-07-01 false Extent of Federal guarantee under the Federal GSL programs. 682.501 Section 682.501 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) FEDERAL FAMILY...

  17. 77 FR 38199 - Determining Conformity of Federal Actions to State or Federal Implementation Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... From the Federal Register Online via the Government Publishing Office ] ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 93 Determining Conformity of Federal Actions to State or Federal Implementation Plans... conformity purposes, the budget(s) shall not be used to satisfy the requirements of this section....

  18. 41 CFR 101-29.221 - Federal Specifications, Standards and Commercial Item Description Program (Federal...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Standards and Commercial Item Description Program (Federal Standardization Program). 101-29.221 Section 101... Standardization Program). The Federal Specifications, Standards and Commercial Item Description Program is a standardization program developed under authority of the Federal Property and Administrative Services Act of...

  19. 77 FR 48970 - Notice of Proposed Information Collection Requests; Federal Student Aid; 2013-2014 Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... individuals applying for federal student aid including the Free Application for Federal Student Aid (FAFSA... ``* * * shall produce, distribute, and process free of charge common financial reporting forms as described in... submission of the Free Application for Federal Student Aid (FAFSA). After submission of the FAFSA,...

  20. 23 CFR 450.218 - Self-certifications, Federal findings, and Federal approvals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Self-certifications, Federal findings, and Federal approvals. 450.218 Section 450.218 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and...