Science.gov

Sample records for nrc activities related

  1. Current NRC activities related to MQA

    SciTech Connect

    Trottier, C.A.; Nellis, D.O.

    1993-12-31

    The U.S. Nuclear Regulatory Commission`s (NRC`s) interest in measurement quality assurance (MQA) goes back to before 1963, when the Atomic Energy Commission (AEC) published a notice in the Federal Register concerning the need for establishing a Film Dosimetry Calibration Laboratory, and also provided a set of minimum performance criteria to be used by the laboratory in evaluating film dosimetry services used by licensees. The proposed laboratory was not established, but in 1967 the AEC contracted with Battelle`s Pacific Northwest Laboratory (PNL) to evaluate film dosimeter performance criteria and provide a basis for establishing a Film Dosimetry Calibration Laboratory if the study showed that it was needed. Then, in 1973, the Conference of Radiation Control Program Directors (CRCPD), concerned with the state of dosimetry processing and the lack of adequate standards, recommended that the National Bureau of Standards (NBS) direct a performance testing program for personnel dosimetry processing services. Later, in 1976, NRC asked PNL to conduct a study to evaluate the four existing performance standards for personnel dosimetry processing. One result of this study was that the HPSSC standard, which later became ANSI N13.11, was recommended as the standard for use in a national dosimetry processing program. The rest is common knowledge. With the support of numerous other federal agencies and the CRCPD, NRC published a regulation, effective in 1988, that required all processors of personnel dosimeters be accredited under the National Voluntary Laboratory Accreditation Program (NVLAP), operated by the NBS, which is now called the National Institute of Standards and Technology (NIST). At present, there are 75 dosimetry processing laboratories accredited under NVLAP. NRC has also been involved in extremity dosimeters, health physics survey instruments, bioassay measurements, electronic personnel dosimeters, and environmental monitoring around nuclear power plants.

  2. Recent NRC research activities addressing valve and pump issues

    SciTech Connect

    Morrison, D.L.

    1996-12-01

    The mission of the U.S. Nuclear Regulatory Commission (NRC) is to ensure the safe design, construction, and operation of commercial nuclear power plants and other facilities in the U.S.A. One of the main roles that the Office of Nuclear Regulatory Research (RES) plays in achieving the NRC mission is to plan, recommend, and implement research programs that address safety and technical issues deemed important by the NRC. The results of the research activities provide the bases for developing NRC positions or decisions on these issues. Also, RES performs confirmatory research for developing the basis to evaluate industry responses and positions on various regulatory requirements. This presentation summarizes some recent RES supported research activities that have addressed safety and technical issues related to valves and pumps. These activities include the efforts on determining valve and motor-operator responses under dynamic loads and pressure locking events, evaluation of monitoring equipment, and methods for detecting and trending aging of check valves and pumps. The role that RES is expected to play in future years to fulfill the NRC mission is also discussed.

  3. Risk-informed inservice test activities at the NRC

    SciTech Connect

    Fischer, D.; Cheok, M.; Hsia, A.

    1996-12-01

    The operational readiness of certain safety-related components is vital to the safe operation of nuclear power plants. Inservice testing (IST) is one of the mechanisms used by licensees to ensure this readiness. In the past, the type and frequency of IST have been based on the collective best judgment of the NRC and industry in an ASME Code consensus process and NRC rulemaking process. Furthermore, IST requirements have not explicitly considered unique component and system designs and contribution to overall plant risk. Because of the general nature of ASME Code test requirements and non-reliance on risk estimates, current IST requirements may not adequately emphasize testing those components that are most important to safety and may overly emphasize testing of less safety significant components. Nuclear power plant licensees are currently interested in optimizing testing by applying resources in more safety significant areas and, where appropriate, reducing measures in less safety-significant areas. They are interested in maintaining system availability and reducing overall maintenance costs in ways that do not adversely affect safety. The NRC has been interested in using probabilistic, as an adjunct to deterministic, techniques to help define the scope, type and frequency of IST. The development of risk-informed IST programs has the potential to optimize the use of NRC and industry resources without adverse affect on safety.

  4. NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC.

    PubMed

    Mahajan, Muktar A; Murray, Audrey; Samuels, Herbert H

    2002-10-01

    We previously reported the cloning and characterization of a novel nuclear hormone receptor transcriptional coactivator, which we refer to as NRC. NRC is a 2,063-amino-acid nuclear protein which contains a potent N-terminal activation domain and several C-terminal modules which interact with CBP and ligand-bound nuclear hormone receptors as well as c-Fos and c-Jun. In this study we sought to clone and identify novel factors that interact with NRC to modulate its transcriptional activity. Here we describe the cloning and characterization of a novel protein we refer to as NIF-1 (NRC-interacting factor 1). NIF-1 was cloned from rat pituitary and human cell lines and was found to interact in vivo and in vitro with NRC. NIF-1 is a 1,342-amino-acid nuclear protein containing a number of conserved domains, including six Cys-2/His-2 zinc fingers, an N-terminal stretch of acidic amino acids, and a C-terminal leucine zipper-like motif. Zinc fingers 1 to 3 are potential DNA-binding BED finger domains recently proposed to play a role in altering local chromatin architecture. We mapped the interaction domains of NRC and NIF-1. Although NIF-1 does not directly interact with nuclear receptors, it markedly enhances ligand-dependent transcriptional activation by nuclear hormone receptors in vivo as well as activation by c-Fos and c-Jun. These results, and the finding that NIF-1 interacts with NRC in vivo, suggest that NIF-1 functions to regulate transcriptional activation through NRC. We suggest that NIF-1, and factors which associate with coactivators but not receptors, be referred to as cotransducers, which act in vivo either as part of a coactivator complex or downstream of a coactivator complex to modulate transcriptional activity. Our findings suggest that NIF-1 may be a functional component of an NRC complex and acts as a regulator or cotransducer of NRC function.

  5. Comparisons of ASTM standards cited in the NRC standard review plan, NUREG-0800 and related documents

    SciTech Connect

    Ankrum, A.R.; Bohlander, K.L.; Gilbert, E.R.; Pawlowski, R.A.; Spiesman, J.B.

    1995-10-01

    This report provides the results of comparisons of the cited and latest versions of ASTM standards cited in the NRC Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants (NUREG 0800) and related documents. The comparisons were performed by Battelle Pacific Northwest Laboratories in support of the NRC`s Standard Review Plan Update and Development Program. Significant changes to the standards, from the cited version to the latest version, are described and discussed in a tabular format for each standard. Recommendations for updating each citation in the Standard Review Plan are presented. Technical considerations and suggested changes are included for related regulatory documents (i.e., Regulatory Guides and the Code of Federal Regulations) citing the standard. The results and recommendations presented in this document have not been subjected to NRC staff review.

  6. Comparisons of ANSI standards cited in the NRC standard review plan, NUREG-0800 and related documents

    SciTech Connect

    Ankrum, A.R.; Bohlander, K.L.; Gilbert, E.R.; Pawlowski, R.A.; Spiesman, J.B.

    1995-11-01

    This report provides the results of comparisons of the cited and latest versions of ANSI standards cited in the NRC Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants (NUREG 0800) and related documents. The comparisons were performed by Battelle Pacific Northwest Laboratories in support of the NRC`s Standard Review Plan Update and Development Program. Significant changes to the standards, from the cited version to the latest version, are described and discussed in a tabular format for each standard. Recommendations for updating each citation in the Standard Review Plan are presented. Technical considerations and suggested changes are included for related regulatory documents (i.e., Regulatory Guides and the Code of Federal Regulations) citing the standard. The results and recommendations presented in this document have not been subjected to NRC staff review.

  7. 77 FR 31045 - Order Prohibiting Involvement in NRC-Licensed Activities; In the Matter of Jaime Sánchez

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... [Federal Register Volume 77, Number 101 (Thursday, May 24, 2012)] [Notices] [Pages 31045-31047] [FR Doc No: 2012-12621] NUCLEAR REGULATORY COMMISSION [NRC-2012-0115; IA-11-036] Order Prohibiting Involvement in NRC-Licensed Activities; In the Matter of Jaime S[aacute]nchez I Jaime S[aacute]nchez (Mr....

  8. Web-based training related to NRC staff review of dose modeling aspects of license termination and decommissioning plans.

    SciTech Connect

    LePoire, D.; Arnish, J.; Cheng, J. J.; Kamboj, S.; Richmond, P.; Chen, S. Y.; Barr, C.; McKenney, C.; Environmental Science Division; NRC

    2007-01-01

    final status surveys are addressed in the WBT. Realistic case examples are presented and analyzed including the abstraction of a realistic site into a conceptual model and computer model. A case history is also used to demonstrate development of NRC review documents such as requests for additional information (RAIs). To enhance the web-based training experience, audio, animations, linked documents, quizzes, and scripts are being integrated with a commercial web-based training package that supports simple navigation. The course is also being integrated into both existing and state-of-the-art learning management systems. A testing group is being utilized to identify and help resolve training issues prior to deployment of the course. When completed, the course can be accessed for credited training with required modules dependent on the job category of the training participant. The modules will also be accessible to NRC staff for review or refresher following initial course completion. WBT promotes consistency in reviews and has the advantage of being able to be used as a resource to staff at any time. The WBT provides reviewers with knowledge needed to perform risk-informed analyses (e.g., information related to development of realistic scenarios and use of probabilistic analysis). WBT on review of LTP or DP dose modeling promotes staff development, efficiency, and effectiveness in performing risk-informed, performance-based reviews of decommissioning activities at NRC-licensed facilities.

  9. Web-based training related to NRC staff review of dose modeling aspects of license termination and decommissioning plans

    SciTech Connect

    LePoire, D.; Arnish, J.; Cheng, J.J.; Kamboj, S.; Richmond, P.; Chen, S.Y.; Barr, C.; McKenney, C.

    2007-07-01

    final status surveys are addressed in the WBT. Realistic case examples are presented and analyzed including the abstraction of a realistic site into a conceptual model and computer model. A case history is also used to demonstrate development of NRC review documents such as requests for additional information (RAIs). To enhance the web-based training experience, audio, animations, linked documents, quizzes, and scripts are being integrated with a commercial web-based training package that supports simple navigation. The course is also being integrated into both existing and state-of-the-art learning management systems. A testing group is being utilized to identify and help resolve training issues prior to deployment of the course. When completed, the course can be accessed for credited training with required modules dependent on the job category of the training participant. The modules will also be accessible to NRC staff for review or refresher following initial course completion. WBT promotes consistency in reviews and has the advantage of being able to be used as a resource to staff at any time. The WBT will provide reviewers with knowledge needed to perform risk-informed analyses (e.g., information related to development of realistic scenarios and use of probabilistic analysis). WBT on review of LTP or DP dose modeling will promote staff development, efficiency, and effectiveness in performing risk-informed, performance-based reviews of decommissioning activities at NRC-licensed facilities. (authors)

  10. NRC Waste Incidental to Reprocessing Program: Overview of Consultation and Monitoring Activities at the Idaho National Laboratory and the Savannah River Site - What We Have Learned - 12470

    SciTech Connect

    Suber, Gregory

    2012-07-01

    In 2005 the U.S. Nuclear Regulatory Commission (NRC) began to implement a new set of responsibilities under the Ronald W. Reagan National Defense Authorization Act (NDAA) of Fiscal Year 2005. Section 3116 of the NDAA requires the U.S. Department of Energy (DOE) to consult with the NRC for certain non-high level waste determinations and also requires NRC to monitor DOE's disposal actions related to those determinations. In Fiscal Year 2005, the NRC staff began consulting with DOE and completed reviews of draft waste determinations for salt waste at the Savannah River Site. In 2006, a second review was completed on tank waste residuals including sodium-bearing waste at the Idaho Nuclear Technology and Engineering Center Tank Farm at the Idaho National Laboratory. Monitoring Plans were developed for these activities and the NRC is actively monitoring disposal actions at both sites. NRC is currently in consultation with DOE on the F-Area Tank Farm closure and anticipates entering consultation on the H-Area Tank Farm at the Savannah River Site. This paper presents, from the NRC perspective, an overview of how the consultation and monitoring process has evolved since its conception in 2005. It addresses changes in methods and procedures used to collect and develop information used by the NRC in developing the technical evaluation report and monitoring plan under consultation and the implementation the plan under monitoring. It will address lessons learned and best practices developed throughout the process. The NDAA has presented significant challenges for the NRC and DOE. Past and current successes demonstrate that the NDAA can achieve its intended goal of facilitating tank closure at DOE legacy defense waste sites. The NRC believes many of the challenges in performing the WD reviews have been identified and addressed. Lessons learned have been collected and documented throughout the review process. Future success will be contingent on each agencies commitment to

  11. 77 FR 30332 - Mr. James Chaisson; Order Prohibiting Involvement in NRC-Licensed Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ..., 2011. II From June 4, 2009, through November 30, 2010, the NRC conducted a safety and security... TGR's radioactive material license, and (2) deliberately failed to implement NRC security requirements..., which required TGR to comply with NRC security requirements. Mr. Chaisson chose to store a...

  12. The NRC activities concerning Boraflex use in spent-fuel storage racks

    SciTech Connect

    Kopp, L.I.

    1996-12-31

    The U.S. Nuclear Regulatory Commission (NRC) has issued several generic communications to the nuclear industry identifying two issues with respect to using Boraflex in spent-fuel storage racks. The first issue related to gamma-radiation-induced shrinkage of Boraflex and the potential to develop tears or gaps in the material. This phenomenon is typically accounted for in criticality analyses of spent-fuel storage racks. The second issue concerned long-term Boraflex performance throughout the intended service life of the racks as a result of both gamma irradiation and exposure to the wet pool environment.

  13. Comparisons of ANS, ASME, AWS, and NFPA standards cited in the NRC standard review plan, NUREG-0800, and related documents

    SciTech Connect

    Ankrum, A.R.; Bohlander, K.L.; Gilbert, E.R.; Spiesman, J.B.

    1995-11-01

    This report provides the results of comparisons of the cited and latest versions of ANS, ASME, AWS and NFPA standards cited in the NRC Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants (NUREG 0800) and related documents. The comparisons were performed by Battelle Pacific Northwest Laboratories in support of the NRC`s Standard Review Plan Update and Development Program. Significant changes to the standards, from the cited version to the latest version, are described and discussed in a tabular format for each standard. Recommendations for updating each citation in the Standard Review Plan are presented. Technical considerations and suggested changes are included for related regulatory documents (i.e., Regulatory Guides and the Code of Federal Regulations) citing the standard. The results and recommendations presented in this document have not been subjected to NRC staff review.

  14. 75 FR 64749 - Request for Comments on the Use of Electronic Signatures for NRC Documents Related to the Medical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... the use of electronic signatures on documents related to the medical use of byproduct material which... COMMISSION Request for Comments on the Use of Electronic Signatures for NRC Documents Related to the Medical Use of Byproduct Material Maintained at Licensees' Facilities AGENCY: Nuclear Regulatory...

  15. Review of nuclear power plant offsite power source reliability and related recommended changes to the NRC rules and regulations

    SciTech Connect

    Battle, R.E.; Clark, F.H.; Reddoch, T.W.

    1980-05-01

    The NRC has stated its concern about the reliability of the offsite power system as the preferred emergency source and about the possible damage to a pressurized water reactor (PWR) that could result from a rapid decay of power grid frequency. ORNL contracted with NRC to provide technical assistance to establish criteria that can be used to evaluate the offsite power system for the licensing of a nuclear power plant. The results of many of the studies for this contract are recommendations to assess and control the power grid during operation. This is because most of the NRC regulations pertaining to the offsite power system are related to the design of the power grid, and we believe that additional emphasis on monitoring the power grid operation will improve the reliability of the nuclear plant offsite power supply. 46 refs., 10 figs.

  16. NRC visit

    NASA Image and Video Library

    2012-08-22

    Four members of the National Research Council visited Stennis Space Center on Aug. 22, touring test stands and facilities, and holding roundtable discussions with Stennis leaders. The NRC mission is to improve government decision making and public policy, increase public understanding, and promote the acquisition and dissemination of knowledge in matters involving science, engineering, technology and health.

  17. 75 FR 10526 - In the Matter of Mr. Lawrence E. Grimm; Order Prohibiting Involvement in NRC-Licensed Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION In the Matter of Mr. Lawrence E. Grimm; Order Prohibiting Involvement in NRC-Licensed Activities I Mr. Lawrence E. Grimm was employed as a radiation safety officer at the U.S. Department of...

  18. 77 FR 3010 - In the Matter of Mr. Francis Guilbeau; Order Prohibiting Involvement in NRC-Licensed Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-20

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION In the Matter of Mr. Francis Guilbeau; Order Prohibiting Involvement in NRC-Licensed Activities I Mr. Francis Guilbeau was employed as a Radiographer at Accurate NDE & Inspection, LLC, (Accurate NDE or Licensee) located in Broussard, Louisiana, in...

  19. 76 FR 11529 - Gregory Desobry, Ph.D.; Order Requiring Notification of Involvement in NRC-Licensed Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... Physics Program (NHPP) conducted onsite inspections at the PVAMC on May 28 through 29, 2008, and from June... American Board of Radiology in 1989 and subsequent practice in the field of Medical Physics, Mr. Desobry's... understands the applicable NRC regulations, and would perform future activities in accordance with applicable...

  20. NRC-interacting factor directs neurite outgrowth in an activity-dependent manner.

    PubMed

    Zhao, X-S; Fu, W-Y; Hung, K-W; Chien, W W Y; Li, Z; Fu, A K; Ip, N Y

    2015-03-19

    Nuclear hormone receptor coregulator-interacting factor 1 (NIF-1) is a zinc finger nuclear protein that was initially identified to enhance nuclear hormone receptor transcription via its interaction with nuclear hormone receptor coregulator (NRC). NIF-1 may regulate gene transcription either by modulating general transcriptional machinery or remodeling chromatin structure through interactions with specific protein partners. We previously reported that the cytoplasmic/nuclear localization of NIF-1 is regulated by the neuronal Cdk5 activator p35, suggesting potential neuronal functions for NIF-1. The present study reveals that NIF-1 plays critical roles in regulating neuronal morphogenesis at early stages. NIF-1 was prominently expressed in the nuclei of developing rat cortical neurons. Knockdown of NIF-1 expression attenuated both neurite outgrowth in cultured cortical neurons and retinoic acid (RA)-treated Neuro-2a neuroblastoma cells. Furthermore, activity-induced Ca(2+) influx, which is critical for neuronal morphogenesis, stimulated the nuclear localization of NIF-1 in cortical neurons. Suppression of NIF-1 expression reduced the up-regulation of neuronal activity-dependent gene transcription. These findings collectively suggest that NIF-1 directs neuronal morphogenesis during early developmental stages through modulating activity-dependent gene transcription.

  1. 75 FR 55366 - In the Matter of Mark M. Ficek; Order Prohibiting Involvement in NRC-Licensed Activities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... to the locking mechanism; (6) failure to notify the NRC after discovery of damage to a radiographic... in NRC's electronic hearing docket which is available to the public at http://ehd.nrc.gov/EHD...

  2. NRC - regulator of nuclear safety

    SciTech Connect

    1997-05-01

    The U.S. Nuclear Regulatory Commission (NRC) was formed in 1975 to regulate the various commercial and institutional uses of nuclear energy, including nuclear power plants. The agency succeeded the Atomic Energy Commission, which previously had responsibility for both developing and regulating nuclear activities. Federal research and development work for all energy sources, as well as nuclear weapons production, is now conducted by the U.S. Department of Energy. Under its responsibility to protect public health and safety, the NRC has three principal regulatory functions: (1) establish standards and regulations, (2) issue licenses for nuclear facilities and users of nuclear materials, and (3) inspect facilities and users of nuclear materials to ensure compliance with the requirements. These regulatory functions relate to both nuclear power plants and to other uses of nuclear materials - like nuclear medicine programs at hospitals, academic activities at educational institutions, research work, and such industrial applications as gauges and testing equipment. The NRC places a high priority on keeping the public informed of its work. The agency recognizes the interest of citizens in what it does through such activities as maintaining public document rooms across the country and holding public hearings, public meetings in local areas, and discussions with individuals and organizations.

  3. 77 FR 39270 - In the Matter of Mr. Timothy Goold; Order Prohibiting Involvement in NRC-Licensed Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ...'s deliberate misconduct rule. The NRC offered Mr. Goold the opportunity to respond in writing... NRC's rule prohibiting deliberate misconduct, 10 CFR 30.10. First, Mr. Goold engaged in deliberate misconduct in violation of 10 CFR 30.10(a)(1) by performing radiography without a second person...

  4. 76 FR 11526 - In the Matter of Dr. Gary Kao; Order Prohibiting Involvement In NRC-Licensed Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... medical events, the VA National Health Physics Program (NHPP) conducted onsite inspections at the PVAMC on...; (2) ensure that he fully understood NRC's definition of a medical event and the steps that he needed... indicated that Dr. Kao had taken any actions to gain understanding of the NRC's definition of a medical...

  5. Anti-Microbial, Anti-Biofilm Activities and Cell Selectivity of the NRC-16 Peptide Derived from Witch Flounder, Glyptocephalus cynoglossus

    PubMed Central

    Gopal, Ramamourthy; Lee, Jun Ho; Kim, Young Gwon; Kim, Myeong-Sun; Seo, Chang Ho; Park, Yoonkyung

    2013-01-01

    Previous studies had identified novel antimicrobial peptides derived from witch flounder. In this work, we extended the search for the activity of peptide that showed antibacterial activity on clinically isolated bacterial cells and bacterial biofilm. Pseudomonas aeruginosa was obtained from otitis media and cholelithiasis patients, while Staphylococcus aureus was isolated from otitis media patients. We found that synthetic peptide NRC-16 displays antimicrobial activity and is not sensitive to salt during its bactericidal activity. Interestingly, this peptide also led to significant inhibition of biofilm formation at a concentration of 4–16 μM. NRC-16 peptide is able to block biofilm formation at concentrations just above its minimum inhibitory concentration while conventional antibiotics did not inhibit the biofilm formation except ciprofloxacin and piperacillin. It did not cause significant lysis of human RBC, and is not cytotoxic to HaCaT cells and RAW264.7 cells, thereby indicating its selective antimicrobial activity. In addition, the peptide’s binding and permeation activities were assessed by tryptophan fluorescence, calcein leakage and circular dichroism using model mammalian membranes composed of phosphatidylcholine (PC), PC/cholesterol (CH) and PC/sphingomyelin (SM). These experiments confirmed that NRC-16 does not interact with any of the liposomes but the control peptide melittin did. Taken together, we found that NRC-16 has potent antimicrobial and antibiofilm activities with less cytotoxicity, and thus can be considered for treatment of microbial infection in the future. PMID:23760014

  6. Economical and financial analysis of lamb finishing fed with diets formulated according to the NRC (1985) and the NRC (2007).

    PubMed

    Rogério, Marcos Cláudio Pinheiro; de Castro, Eliane Minervina; Martins, Espedito Cezário; Monteiro, Jomar Patrício; Silva, Kleibe de Moraes; Cândido, Magno José Duarte; Gomes, Tereza Cristina Lacerda; Bloc, Antoine Francis Roux; de Vasconcelos, Angela Maria; Leite, Eneas Reis; Costa, Hélio Henrique Araújo

    2013-01-01

    This study compares both versions of the nutritional requirement system determined by the National Research Council (NRC) version 1985 (NRC85) and NRC version 2007 (NRC07), for finishing lambs in feedlots. Nineteen crossbred lambs were divided in four groups representing four experimental treatments: one diet according to NRC85 and three diets according to NRC07. The diets recommended by NRC07 considers crude protein intake relative to ruminal undegradable protein at 20, 40, and 60 % levels (NRC07/20, NRC07/40, and NRC07/60). Diets were composed of Brazilian semi-arid native grass silage, soybean meal, corn, annatto byproduct, and limestone. Purchases and sales of lambs were done according to average market prices in Brazil. The economic indicators considered pointed that all treatments were viable but NRC07/20 and NRC07/60 were more profitable with similar net present values (NPVs) and internal return rates (IRRs). NRC07/20 was the best option showing an IRR of 17.20 % and a payback period (PP) of 5.07 considering a fixed annual interest rate of 6 %. Sensitivity analysis considering a 10 % raise in variable costs showed negative NPVs, IRRs inferior to the opportunity cost rates adopted and PPs that exceeded the planning horizon of 7 years for both NRC85 and NRC07/40.

  7. NRC Targets University Reactors.

    ERIC Educational Resources Information Center

    Marshall, Eliot

    1984-01-01

    The Nuclear Regulatory Commission (NRC) wants universities to convert to low-grade fuel in their research reactions. Researchers claim the conversion, which will bring U.S. reactors in line with a policy the NRC is trying to impress on foreigners, could be financially and scientifically costly. Impact of the policy is considered. (JN)

  8. NRC Targets University Reactors.

    ERIC Educational Resources Information Center

    Marshall, Eliot

    1984-01-01

    The Nuclear Regulatory Commission (NRC) wants universities to convert to low-grade fuel in their research reactions. Researchers claim the conversion, which will bring U.S. reactors in line with a policy the NRC is trying to impress on foreigners, could be financially and scientifically costly. Impact of the policy is considered. (JN)

  9. NRC antitrust licensing actions, 1978--1996

    SciTech Connect

    Mayer, S.J.; Simpson, J.J.

    1997-09-01

    NUREG-0447, Antitrust Review of Nuclear Power Plants, was published in May 1978 and includes a compilation and discussion of U.S. Nuclear Regulatory Commission (NRC) proceedings and activity involving the NRC`s competitive review program through February 1978, NUREG-0447 is an update of an earlier discussion of the NRC`s antitrust review of nuclear power plants, NR-AIG-001, The US Nuclear Regulatory Commission`s Antitrust Review of Nuclear Power Plants: The Conditioning of Licenses, which reviewed the Commission`s antitrust review function from its inception in December 1970 through April 1976. This report summarizes the support provided to NRC staff in updating the compilation of the NRC`s antitrust licensing review activities for commercial nuclear power plants that have occurred since February 1978. 4 refs., 4 tabs.

  10. Materials reliability. Technical activities, 1992. (NAS-NRC Assessment Panel, 13-14 May 1993)

    NASA Astrophysics Data System (ADS)

    McHenry, H. I.; Fortunko, C. M.

    The Materials Reliability Division conducts materials research to improve the quality, reliability, and safety of industrial products and the nation's infrastructure. The authors' research fosters the use of advanced materials in commercial products by improving confidence in their service performance. The authors do this by developing measurement technology for: process control which improves the quality, consistency and producibility of materials; nondestructive evaluation (NDE) which assures the quality of finished materials and products; fitness-for-purpose standards which relate material quality to reliability and safety; and materials evaluation for severe applications, particularly for service at cryogenic temperatures. Early in FY92, the authors reorganized the Division to build a stronger group structure. The report summarizes the Division programs, and it is organized according to the three groups: materials characterization; process sensing and modeling; and structural materials.

  11. U.S. NRC CONFIRMATORY LEVEL 1 PRA SUCCESS CRITERIA ACTIVITIES

    SciTech Connect

    Donald Helton; Hossein Esmaili; Robert Buell

    2011-03-01

    The U.S. Nuclear Regulatory Commission’s standardized plant analysis risk (SPAR) models are used to support a number of risk-informed initiatives. The fidelity and realism of these models are ensured through a number of processes including cross-comparison with industry models, review and use by a wide range of technical experts, and confirmatory analysis. This paper will describe a key activity in the latter arena. Specifically, this paper will describe MELCOR analyses performed to augment the technical basis for confirming or modifying specific success criteria of interest. The analyses that will be summarized provide the basis for confirming or changing success criteria in a specific 3-loop pressurized-water reactor and a Mark-I boiling-water reactor. Initiators that have been analyzed include loss-of-coolant accidents, loss of main feedwater, spontaneous steam generator tube rupture, inadvertent opening of a relief valve at power, and station blackout. For each initiator, specific aspects of the accident evolution are investigated via a targeted set of calculations (3 to 22 distinct accident analyses per initiator). Further evaluation is ongoing to extend the analyses’ conclusions to similar plants (where appropriate), with consideration of design and modeling differences on a scenario-by-scenario basis. This paper will also describe future plans.

  12. NRC disposed to site

    NASA Astrophysics Data System (ADS)

    Carlowicz, Michael

    A committee of the National Research Council (NRC) has found the risk of human exposure to radiation from nuclear waste to be minimal at a proposed underground disposal site. In a report on the U.S. Department of Energy's (DOE) Waste Isolation Pilot Plant (WIPP) in southeastern New Mexico, the NRC committee asserted that the danger of radioactive exposure at the site is unlikely to exceed U.S. and international standards for protection from radiation. Unless the site is breached by humans—most likely those drilling for gas or oil—there is no credible or probable chance of the release of the radioactive waste, the committee said.

  13. 1996 NRC annual report. Volume 13

    SciTech Connect

    1997-10-01

    This 22nd annual report of the US Nuclear Regulatory Commission (NRC) describes accomplishments, activities, and plans made during Fiscal Year 1996 (FH 1996)--October 1, 1995, through September 30, 1996. Significant activities that occurred early in FY 1997 are also described, particularly changes in the Commission and organization of the NRC. The mission of the NRC is to ensure that civilian uses of nuclear materials in the US are carried out with adequate protection of public health and safety, the environment, and national security. These uses include the operation of nuclear power plants and fuel cycle plants and medical, industrial, and research applications. Additionally, the NRC contributes to combating the proliferation of nuclear weapons material worldwide. The NRC licenses and regulates commercial nuclear reactor operations and research reactors and other activities involving the possession and use of nuclear materials and wastes. It also protects nuclear materials used in operation and facilities from theft or sabotage. To accomplish its statutorily mandated regulatory mission, the NRC issues rules and standards, inspects facilities and operations, and issues any required enforcement actions.

  14. Status of the NRC Decommissioning Program

    SciTech Connect

    Orlando, D. A.; Camper, L.; Buckley, J.; Pogue, E.; Banovac, K.

    2003-02-24

    On July 21, 1997, the U.S. Nuclear Regulatory Commission (NRC) published the final rule on Radiological Criteria for License Termination (the License Termination Rule or LTR) as Subpart E to 10 CFR Part 20. NRC regulations require that materials licensees submit Decommissioning Plans to support the decommissioning of its facility if it is required by license condition, or if the procedures and activities necessary to carry out the decommissioning have not been approved by NRC and these procedures could increase the potential health and safety impacts to the workers or the public. NRC regulations also require that reactor licensees submit Post-shutdown Decommissioning Activities Reports and License Termination Plans to support the decommissioning of nuclear power facilities. This paper provides an update on the status of the NRC's decommissioning program that was presented during WM'02. It discusses the staff's current efforts to streamline the decommissioning process, current issues being faced in the decommissioning program, such as partial site release and restricted release of sites, as well as the status of the decommissioning of complex sites and those listed in the Site Decommissioning Management Plan. The paper discusses the status of permanently shut-down commercial power reactors and the transfer of complex decommissioning sites and sites listed on the SDMP to Agreement States. Finally the paper provides an update of the status of various tools and guidance the NRC is developing to assist licensees during decommissioning, including an effort to consolidate and risk-inform decommissioning guidance.

  15. NRC plan for cleanup operations at Three Mile Island Unit 2. Rev. 2

    SciTech Connect

    Masnik, M.T.; Snyder, B.J.

    1984-03-01

    This report updates a plan that defines NRC's role in cleanup operations at Three Mile Island Unit 2 (TMI-2) and outlines NRC's regulatory responsibilities in fulfilling this role. These responsibilities include reviewing and approving General Public Utilities Nuclear Corporation (the licensee) proposals for cleanup actions, overseeing the licensee's implementation of approved activities, coordinating wih other federal and state governmental agencies on their activities in the cleanup, and informing local officials and the public about the status of the cleanup. Since the initial issuance of this NRC Plan in July 1980, this office has issued the Final NRC Programmatic Environmental Impact Statement (PEIS) related to the entire TMI-2 cleanup and a draft Supplement to the PEIS related to occupational radiation exposure. Additionally, a number of developments have occurred which will have an impact on the course of cleanup operations. This revision provides a discussion of these developments, specifically in the areas of the functinal role of the NRC in cleanup operations, the cleanup schedule, and the current status of the cleanup. The plan also discusses NRC's perceived role in future cleanup activities.

  16. 78 FR 66968 - In the Matter of Landon E. Brittain; Order Prohibiting Involvement In NRC-Licensed Activities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ..., began planning and attempted to recruit other resources to assist in an armored car robbery. However, on... employee, and the egregiousness of Mr. Brittain's apparent criminal activities related to the carjacking, and the planning of such activities with his fellow employee, and pursuant to Sections 161b, 161i, and...

  17. NRC regulatory initiatives

    SciTech Connect

    Johnson, T.C.

    1989-11-01

    The US Nuclear Regulatory Commission (NRC) is addressing several low-level waste disposal issues that will be important to waste generators and to States and Compacts developing new disposal capacity. These issues include Greater-Than-Class C (GTCC) waste, mixed waste, below regulatory concern (BRC) waste, and the low-level waste data base. This paper discusses these issues and their current status.

  18. Genome sequence of Halobacterium species NRC-1

    PubMed Central

    Ng, Wailap Victor; Kennedy, Sean P.; Mahairas, Gregory G.; Berquist, Brian; Pan, Min; Shukla, Hem Dutt; Lasky, Stephen R.; Baliga, Nitin S.; Thorsson, Vesteinn; Sbrogna, Jennifer; Swartzell, Steven; Weir, Douglas; Hall, John; Dahl, Timothy A.; Welti, Russell; Goo, Young Ah; Leithauser, Brent; Keller, Kim; Cruz, Randy; Danson, Michael J.; Hough, David W.; Maddocks, Deborah G.; Jablonski, Peter E.; Krebs, Mark P.; Angevine, Christine M.; Dale, Heather; Isenbarger, Thomas A.; Peck, Ronald F.; Pohlschroder, Mechthild; Spudich, John L.; Jung, Kwang-Hwan; Alam, Maqsudul; Freitas, Tracey; Hou, Shaobin; Daniels, Charles J.; Dennis, Patrick P.; Omer, Arina D.; Ebhardt, Holger; Lowe, Todd M.; Liang, Ping; Riley, Monica; Hood, Leroy; DasSarma, Shiladitya

    2000-01-01

    We report the complete sequence of an extreme halophile, Halobacterium sp. NRC-1, harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 families and organized into a large chromosome and 2 related minichromosomes. The Halobacterium NRC-1 genome codes for 2,630 predicted proteins, 36% of which are unrelated to any previously reported. Analysis of the genome sequence shows the presence of pathways for uptake and utilization of amino acids, active sodium-proton antiporter and potassium uptake systems, sophisticated photosensory and signal transduction pathways, and DNA replication, transcription, and translation systems resembling more complex eukaryotic organisms. Whole proteome comparisons show the definite archaeal nature of this halophile with additional similarities to the Gram-positive Bacillus subtilis and other bacteria. The ease of culturing Halobacterium and the availability of methods for its genetic manipulation in the laboratory, including construction of gene knockouts and replacements, indicate this halophile can serve as an excellent model system among the archaea. PMID:11016950

  19. 78 FR 66970 - In the Matter of Michael J. Buhrman; Order Prohibiting Involvement in NRC-Licensed Activities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... mid-July 2011, Mr. Buhrman, along with another SRO, began planning and attempted to recruit other... related to the carjacking, and the planning of such activities with his fellow employee, and pursuant to... writing, relax or rescind any of the above conditions upon demonstration by Mr. Buhrman of good cause. V...

  20. STATUS OF THE NRC'S DECOMMISSIONING PROGRAM

    SciTech Connect

    Orlando, D. A.; Camper, L. W.; Buckley, J.

    2002-02-25

    On July 21, 1997, the U.S. Nuclear Regulatory Commission published the final rule on Radiological Criteria for License Termination (the License Termination Rule) as Subpart E to 10 CFR Part 20. NRC regulations require that materials licensees submit Decommissioning Plans to support the decommissioning of its facility if it is required by license condition, or if the procedures and activities necessary to carry out the decommissioning have not been approved by NRC and these procedures could increase the potential health and safety impacts to the workers or the public. NRC regulations also require that reactor licensees submit Post-shutdown Decommissioning Activities Reports and License Termination Plans to support the decommissioning of nuclear power facilities. This paper provides an update on the status of the NRC's decommissioning program. It discusses the status of permanently shut-down commercial power reactors, complex decommissioning sites, and sites listed in the Site Decommissioning Management Plan. The paper provides the status of various tools and guidance the NRC is developing to assist licensees during decommissioning, including a Standard Review Plan for evaluating plans and information submitted by licensees to support the decommissioning of nuclear facilities and the D and D Screen software for determining the potential doses from residual radioactivity. Finally, it discusses the status of the staff's current efforts to streamline the decommissioning process.

  1. Overview of NRC PRA research program

    SciTech Connect

    Cunningham, M.A.; Drouin, M.T.; Ramey-Smith, A.M.; VanderMolen, M.T.

    1997-02-01

    The NRC`s research program in probabilistic risk analysis includes a set of closely-related elements, from basic research to regulatory applications. The elements of this program are as follows: (1) Development and demonstration of methods and advanced models and tools for use by the NRC staff and others performing risk assessments; (2) Support to agency staff on risk analysis and statistics issues; (3) Reviews of risk assessments submitted by licensees in support of regulatory applications, including the IPEs and IPEEEs. Each of these elements is discussed in the paper, providing highlights of work within an element, and, where appropriate, describing important support and feedback mechanisms among elements.

  2. NRC safety research in support of regulation - FY 1994. Volume 9

    SciTech Connect

    1995-06-01

    This report, the tenth in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1994. The goal of the Office of Nuclear Regulatory Research (RES) is to ensure the availability of sound technical bases for timely rulemaking and related decisions in support of NRC regulatory/licensing/inspection activities. RES also has responsibilities related to the resolution of generic safety issues and to the review of licensee submittals regarding individual plant examinations. It is the responsibility of RES to conduct the NRC`s rulemaking process, including the issuance of regulatory guides and rules that govern NRC licensed activities.

  3. NRC Licensing Status Summary Report for NGNP

    SciTech Connect

    Moe, Wayne Leland; Kinsey, James Carl

    2014-11-01

    The Next Generation Nuclear Plant (NGNP) Project, initiated at Idaho National Laboratory (INL) by the U.S. Department of Energy (DOE) pursuant to provisions of the Energy Policy Act of 2005, is based on research and development activities supported by the Department of Energy Generation IV Nuclear Energy Systems Initiative. The principal objective of the NGNP Project is to support commercialization of high temperature gas-cooled reactor (HTGR) technology. The HTGR is a helium-cooled and graphite moderated reactor that can operate at temperatures much higher than those of conventional light water reactor (LWR) technologies. The NGNP will be licensed for construction and operation by the Nuclear Regulatory Commission (NRC). However, not all elements of current regulations (and their related implementation guidance) can be applied to HTGR technology at this time. Certain policies established during past LWR licensing actions must be realigned to properly accommodate advanced HTGR technology. A strategy for licensing HTGR technology was developed and executed through the cooperative effort of DOE and the NRC through the NGNP Project. The purpose of this report is to provide a snapshot of the current status of the still evolving pre-license application regulatory framework relative to commercial HTGR technology deployment in the U.S. The following discussion focuses on (1) describing what has been accomplished by the NGNP Project up to the time of this report, and (2) providing observations and recommendations concerning actions that remain to be accomplished to enable the safe and timely licensing of a commercial HTGR facility in the U.S.

  4. Preliminary analysis of DHLW (Defense High-Level Waste) glass performance as related to the NRC 10CFR60 slow release limit criterion

    SciTech Connect

    McGrail, B.P.

    1988-07-01

    A preliminary analysis was performed to determine if the dissolution resistance of Defense High-Level Waste (DHLW) glass in silicia-saturated brine is sufficient to meet the Nuclear Regulatory Commission (NRC) fractional release rate requirement for nuclear waste repositories. The sensitivities of fractional release to variations in temperature, surface area, and matrix solubility were also examined. Results indicate that a waste form dissolution resistance strategy is potentially viable for demonstrating compliance with the NRC regulatory requirement. However, major uncertainties exist in two areas: demonstrating that the brine contacting the glass is saturated in silica, and predicting the exposed glass surface area. 12 refs., 4 figs.

  5. The role of research in nuclear regulation: An NRC perspective

    SciTech Connect

    Morrison, D.L.

    1997-01-01

    The role of research in the US Nuclear Regulatory Commission was broadly defined by the US Congress in the Energy Reorganization Act of 1975. This Act empowered the Commission to do research that it deems necessary for the performance of its licensing and regulatory functions. Congress cited a need for an independent capability that would support the licensing and regulatory process through the development and analysis of technical information related to reactor safety, safeguards and environmental protection. Motivation for establishing such a safety research function within the regulatory agency is the need to address the defects, abnormal occurrences and shutdowns involving light water reactors. Congress further stated that the NRC should limit its research to {open_quotes}confirmatory assessment{close_quotes} and that the Agency {open_quotes}should never be placed in a position to generate, and then have to defend, basic design data of its own.{close_quotes} The author reviews the activities of the research arm as related to regulatory research, performed in the past, today, and projected for the future. NRC`s public health and safety mission demands that its research products be developed independently from its licensees; be credible and of the highest technical quality as established through peer review; and open to the public scrutiny through publication in technical journals as well as NRC documents. A special trust is placed on regulatory research through the products it produces as well as the three dimensions that underlie the processes through which they are produced.

  6. A review of NRC staff uses of probabilistic risk assessment

    SciTech Connect

    Not Available

    1994-03-01

    The NRC staff uses probabilistic risk assessment (PRA) and risk management as important elements its licensing and regulatory processes. In October 1991, the NRC`s Executive Director for Operations established the PRA Working Group to address concerns identified by the Advisory Committee on Reactor Safeguards with respect to unevenness and inconsistency in the staff`s current uses of PRA. After surveying current staff uses of PRA and identifying needed improvements, the Working Group defined a set of basic principles for staff PRA use and identified three areas for improvements: guidance development, training enhancements, and PRA methods development. For each area of improvement, the Working Group took certain actions and recommended additional work. The Working Group recommended integrating its work with other recent PRA-related activities the staff completed and improving staff interactions with PRA users in the nuclear industry. The Working Group took two key actions by developing general guidance for two uses of PRA within the NRC (that is, screening or prioritizing reactor safety issues and analyzing such issues in detail) and developing guidance on basic terms and methods important to the staff`s uses of PRA.

  7. Characterization of hypothetical protein VNG0128C from Halobacterium NRC-1 reveals GALE like activity and its involvement in Leloir pathway of galactose metabolism.

    PubMed

    Reshma, S V; Sathyanarayanan, Nitish; Nagendra, H G

    2015-01-01

    VNG0128C, a hypothetical protein from Halobacterium NRC-1, was chosen for detailed insilico and experimental investigations. Computational exercises revealed that VNG0128C functions as NAD(+) binding protein. The phylogenetic analysis with the homolog sequences of VNG0128C suggested that it could act as UDP-galactose 4-epimerase. Hence, the VNG0128C sequence was modeled using a suitable template and docking studies were performed with NAD and UDP-galactose as ligands. The binding interactions strongly indicate that VNG0128C could plausibly act as UDP-galactose 4-epimerase. In order to validate these insilico results, VNG0128C was cloned in pUC57, subcloned in pET22b(+), expressed in BL21 cells and purified using nickel affinity chromatography. An assay using blue dextran was performed to confirm the presence of NAD binding domain. To corroborate the epimerase like enzymatic role of the hypothetical protein, i.e. the ability of the enzyme to convert UDP-galactose to UDP-glucose, the conversion of NAD to NADH was measured. The experimental assay significantly correlated with the insilico predictions, indicating that VNG0128C has a NAD(+) binding domain with epimerase activity. Consequently, its key role in nucleotide-sugar metabolism was thus established. Additionally, the work highlights the need for a methodical characterization of hypothetical proteins (less studied class of biopolymers) to exploit them for relevant applications in the field of biology.

  8. NRC Monitoring of Salt Waste Disposal at the Savannah River Site - 13147

    SciTech Connect

    Pinkston, Karen E.; Ridge, A. Christianne; Alexander, George W.; Barr, Cynthia S.; Devaser, Nishka J.; Felsher, Harry D.

    2013-07-01

    As part of monitoring required under Section 3116 of the Ronald W. Reagan National Defense Authorization Act for Fiscal Year 2005 (NDAA), the NRC staff reviewed an updated DOE performance assessment (PA) for salt waste disposal at the Saltstone Disposal Facility (SDF). The NRC staff concluded that it has reasonable assurance that waste disposal at the SDF meets the 10 CFR 61 performance objectives for protection of individuals against intrusion (chap.61.42), protection of individuals during operations (chap.61.43), and site stability (chap.61.44). However, based on its evaluation of DOE's results and independent sensitivity analyses conducted with DOE's models, the NRC staff concluded that it did not have reasonable assurance that DOE's disposal activities at the SDF meet the performance objective for protection of the general population from releases of radioactivity (chap.61.41) evaluated at a dose limit of 0.25 mSv/yr (25 mrem/yr) total effective dose equivalent (TEDE). NRC staff also concluded that the potential dose to a member of the public is expected to be limited (i.e., is expected to be similar to or less than the public dose limit in chap.20.1301 of 1 mSv/yr [100 mrem/yr] TEDE) and is expected to occur many years after site closure. The NRC staff used risk insights gained from review of the SDF PA, its experience monitoring DOE disposal actions at the SDF over the last 5 years, as well as independent analysis and modeling to identify factors that are important to assessing whether DOE's disposal actions meet the performance objectives. Many of these factors are similar to factors identified in the NRC staff's 2005 review of salt waste disposal at the SDF. Key areas of interest continue to be waste form and disposal unit degradation, the effectiveness of infiltration and erosion controls, and estimation of the radiological inventory. Based on these factors, NRC is revising its plan for monitoring salt waste disposal at the SDF in coordination with South

  9. Multi-canister overpack: additional NRC requirements

    SciTech Connect

    Garvin, L.J.

    1995-11-01

    The U.S. Department of Energy (DOE) established in the K Basin Spent Fuel Project, Regulatory Policy, dated August 4, 1995 (hereafter referred to as the Policy), the requirement for new Spent Nuclear Fuel Project (SNFP) facilities to achieve ``nuclear safety equivalency`` to comparable U.S. Nuclear Regulatory Commission licensed facilities. For activities other than during transport, when the Multi-Canister Overpack (MCO) is used and resides in the Canister Storage Building (CSB), Conditioning Facility or K Basins Path Forward Projects, additional NRC requirements will also apply to the MCO based on the safety functions it performs and its interfaces with the SNFP facilities. An evaluation was performed in consideration of the MCO safety functions to identify any additional NRC requirements, to establish nuclear safety equivalency for the MCO.

  10. The role of research in NRC regulatory programs

    SciTech Connect

    Jackson, S.A.

    1996-03-01

    This article is the text of the opening remarks by NRC Chairwoman Shirley Jackson to the Reactor Safety Meeting. In her remarks, Dr. Jackson discusses the role of research in NRC regulatory programs and points out by way of example that many of the research programs provide considerable benefit to the industry as well as to the Commission. She then outlines current activities as well as future plans.

  11. Overview of NRC review process

    SciTech Connect

    Tokar, M.; Kane, J.D.

    1989-11-01

    This paper describes the NRC staff`s review of the Prototype License Application Safety Analysis Report (PLASAR) for an Earth-Mounded Concrete Bunker low-level waste disposal facility. Described are the objectives of the review, the resources (e.g., background guidance documents and staff technical disciplines) used, and the products produced. Evaluation conclusions are summarized.

  12. IRIS and the National Research Council (NRC)

    EPA Pesticide Factsheets

    Since the 2011 National Academies’ National Research Council (NRC) review of the IRIS Program's assessment of Formaldehyde, EPA and NRC have had an ongoing relationship into the improvements of developing the IRIS Assessments.

  13. 76 FR 54986 - NRC Enforcement Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... COMMISSION 10 CFR Chapter I NRC Enforcement Policy AGENCY: Nuclear Regulatory Commission. ACTION: Proposed enforcement policy revision; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the... Enforcement Policy. The NRC staff is currently evaluating these topics for inclusion in the next revision to...

  14. Web-Based Training on Reviewing Dose Modeling Aspects of NRC Decommissioning and License Termination Plans

    SciTech Connect

    LePoire, D.; Cheng, J.J.; Kamboj, S.; Arnish, J.; Richmond, P.; Chen, S.Y.; Barr, C.; McKenney, C.

    2008-01-15

    related to training, developing, and transferring knowledge to NRC staff on how to review dose-modeling portions of licensee-submitted DPs and LTPs. This project identified specific cases and examples, created easily updateable educational modules, represented material in an engaging format through animations, video, and graphics, and distributed information on how to perform these reviews in an accessible, web-based format. WBT promotes consistency in reviews and has the advantage of being able to be used as a resource to staff at any time. The WBT will provide reviewers with knowledge needed to perform risk-informed analyses (e.g., information related to development of realistic scenarios and use of probabilistic analysis). WBT on review of LTP or DP dose modeling will promote staff development, efficiency, and effectiveness in performing risk-informed, performance-based reviews of decommissioning activities at NRC-licensed facilities. One of the key advantages of this type of web-based training is that it can be loaded on-demand and can be reused indefinitely. In addition to the benefits of on-demand training, the modules can also be used for reference. The presentations are hosted on a web server that can be accessed by registered users at any time. Staff can return to a particular module to review the material long after they have completed the course.

  15. NRC plan for cleanup operations at Three Mile Island Unit 2

    SciTech Connect

    Lo, R.; Snyder, B.

    1982-02-01

    This NRC Plan, which defines NRC's functional role in cleanup operations at Three Mile Island Unit 2 and outlines NRC's regulatory responsibilities in fulfilling this role, is the first revision to the initial plan issued in July 1980 (NUREG-0698). Since 1980, a number of policy developments have occurred which will have an impact on the course of cleanup operations. This revision reflects these developments in the area of NRC's review and approval process with regard to cleanup operations as well as NRC's interface with the Department of Energy's involvement in the cleanup and waste disposal. This revision is also intended to update the cleanup schedule by presenting the cleanup progress that has taken place and NRC's role in ongoing and future cleanup activities.

  16. Reassessment of the NRC`s program for protecting allegers against retaliation

    SciTech Connect

    Not Available

    1994-01-01

    On July 6, 1993, the Nuclear Regulatory Commission`s (NRC`s) Executive Director for Operations established a review team to reassess the NRC`s program for protecting allegers against retaliation. The team evaluated the current system, and solicited comments from various NRC offices, other Federal agencies, licensees, former allegers, and the public. This report is subject to agency review. The report summarizes current processes and gives an overview of current problems. It discusses: (1) ways in which licensees can promote a quality-conscious work environment, in which all employees feel free to raise concerns without fear of retaliation; (2) ways to improve the NRC`s overall handling of allegations; (3) the NRC`s involvement in the Department of Labor process; (4) related NRC enforcement practices; and (5) methods other than investigation and enforcement that may be useful in treating allegations of potential or actual discrimination. Recommendations are given in each area.

  17. Hydrogen masers and cesium fountains at NRC

    NASA Technical Reports Server (NTRS)

    Boulanger, J.-S.; Morris, D.; Douglas, R. J.; Gagne, M.-C.

    1994-01-01

    The NRC masers H-3 and H-4 have been operating since June 1993 with cavity servo control. These low-flux active H masers are showing stabilities of about 10(exp -15) from 1 hour to several days. Stability results are presented, and the current and planned uses of the masers are discussed. A cesium fountain primary frequency standard project has been started at NRC. Trapping and launching experiments with the goal of 7 m/s launches are beginning. We discuss our plans for a local oscillator and servo that exploit the pulsed aspect of cesium fountain standards, and meet the challenge of 10(exp -14) tau(exp -1/2) stability without requiring masers. At best, we expect to run this frequency standard initially for periods of hours each working day rather than continuously for years, and so frequency transfer to outside laboratories has been carefully considered. We conclude that masers (or other even better secondary clocks) are required to exploit this potential accuracy of the cesium fountain. We present and discuss our conclusion that it is feasible to transfer frequency in this way with a transfer-induced uncertainty of less than 10(exp -15), even in the presence of maser frequency drift and random walk noise.

  18. The NRC's SPAR Models: Current Status, Future Development, and Modeling Issues

    SciTech Connect

    Robert F. Buell

    2008-09-01

    Probabilistic risk assessments (PRAs) play an increasingly important role in the regulatory framework of the U.S. nuclear power industry. The Nuclear Regulatory Commission (NRC) relies on a set of plant-specific Standardized Plant Analysis Risk (SPAR) models to provide critical risk-based input to the regulatory process. The Significance Determination Process (SDP), Management Directive 8.3 - NRC Incident Investigation Program, Accident Sequence Precursor (ASP) and Mitigating Systems Performance Index (MSPI) programs are among the regulatory initiatives that receive significant input from the SPAR models. Other uses of the SPAR models include: Screening & Resolution of Generic Safety Issues, License Amendment reviews and Notice of Enforcement Discretion (NOEDs). This paper presents the current status of SPAR model development activities, future development objectives, and issues related to the development, verification and maintenance of the SPAR models.

  19. NRC licensing requirements: DOD options

    SciTech Connect

    Pike, W.J.; O'Reilly, P.D.

    1982-09-01

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with /sup 90/Sr or /sup 238/Pu; radioisotopic dynamic electric generators with /sup 90/Sr or /sup 238/Pu; and applications of radioisotopes for luminous sources (lights) with /sup 3/H, /sup 85/Kr, or /sup 147/Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process.

  20. REVIEW OF NRC APPROVED DIGITAL CONTROL SYSTEMS ANALYSIS

    SciTech Connect

    D.W. Markman

    1999-09-17

    Preliminary design concepts for the proposed Subsurface Repository at Yucca Mountain indicate extensive reliance on modern, computer-based, digital control technologies. The purpose of this analysis is to investigate the degree to which the U. S. Nuclear Regulatory Commission (NRC) has accepted and approved the use of digital control technology for safety-related applications within the nuclear power industry. This analysis reviews cases of existing digitally-based control systems that have been approved by the NRC. These cases can serve as precedence for using similar types of digitally-based control technologies within the Subsurface Repository. While it is anticipated that the Yucca Mountain Project (YMP) will not contain control systems as complex as those required for a nuclear power plant, the review of these existing NRC approved applications will provide the YMP with valuable insight into the NRCs review process and design expectations for safety-related digital control systems. According to the YMP Compliance Program Guidance, portions of various NUREGS, Regulatory Guidelines, and nuclear IEEE standards the nuclear power plant safety related concept would be applied to some of the designs on a case-by-case basis. This analysis will consider key design methods, capabilities, successes, and important limitations or problems of selected control systems that have been approved for use in the Nuclear Power industry. An additional purpose of this analysis is to provide background information in support of further development of design criteria for the YMP. The scope and primary objectives of this analysis are to: (1) Identify and research the extent and precedence of digital control and remotely operated systems approved by the NRC for the nuclear power industry. Help provide a basis for using and relying on digital technologies for nuclear related safety critical applications. (2) Identify the basic control architecture and methods of key digital control

  1. 78 FR 5838 - NRC Enforcement Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... COMMISSION NRC Enforcement Policy AGENCY: Nuclear Regulatory Commission. ACTION: Policy revision; issuance... to its Enforcement Policy (Enforcement Policy or Policy) to incorporate changes directed by the... February 27, 2013, and will be considered by the NRC before the next Enforcement Policy revision. ADDRESSES...

  2. 76 FR 76192 - NRC Enforcement Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... COMMISSION NRC Enforcement Policy AGENCY: Nuclear Regulatory Commission. ACTION: Proposed enforcement policy... proposed revisions to the NRC's Enforcement Policy (the Policy) and the effectiveness of the September 30, 2010 (75 FR 60485), revisions to the Policy. The intent of this request for comment is to assist the...

  3. 48 CFR 2009.100 - NRC policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... applies to: (1) The noncompetitive award of contracts to organizations where former NRC employees have dominant ownership interests in the organization, such as partners or majority stockholders; (2) The noncompetitive award of contracts to organizations where former NRC employees have dominant management interests...

  4. NRC Reviewer Aid for Evaluating the Human Factors Engineering Aspects of Small Modular Reactors

    SciTech Connect

    OHara J. M.; Higgins, J.C.

    2012-01-13

    Small modular reactors (SMRs) are a promising approach to meeting future energy needs. Although the electrical output of an individual SMR is relatively small compared to that of typical commercial nuclear plants, they can be grouped to produce as much energy as a utility demands. Furthermore, SMRs can be used for other purposes, such as producing hydrogen and generating process heat. The design characteristics of many SMRs differ from those of current conventional plants and may require a distinct concept of operations (ConOps). The U.S. Nuclear Regulatory Commission (NRC) conducted research to examine the human factors engineering (HFE) and the operational aspects of SMRs. The research identified thirty potential human-performance issues that should be considered in the NRC's reviews of SMR designs and in future research activities. The purpose of this report is to support NRC HFE reviewers of SMR applications by identifying some of the questions that can be asked of applicants whose designs have characteristics identified in the issues. The questions for each issue were identified and organized based on the review elements and guidance contained in Chapter 18 of the Standard Review Plan (NUREG-0800), and the Human Factors Engineering Program Review Model (NUREG-0711).

  5. Proteomic analysis of an extreme halophilic archaeon, Halobacterium sp. NRC-1.

    PubMed

    Goo, Young Ah; Yi, Eugene C; Baliga, Nitin S; Tao, Weiguo A; Pan, Min; Aebersold, Ruedi; Goodlett, David R; Hood, Leroy; Ng, Wailap V

    2003-08-01

    Halobacterium sp. NRC-1 insoluble membrane and soluble cytoplasmic proteins were isolated by ultracentrifugation of whole cell lysate. Using an ion trap mass spectrometer equipped with a C18 trap electrospray ionization emitter/micro-liquid chromatography column, a number of trypsin-generated peptide tags from 426 unique proteins were identified. This represents approximately one-fifth of the theoretical proteome of Halobacterium. Of these, 232 proteins were found only in the soluble fraction, 165 were only in the insoluble membrane fraction, and 29 were in both fractions. There were 72 and 61% previously annotated proteins identified in the soluble and membrane protein fractions, respectively. Interestingly, 57 of previously unannotated proteins found only in Halobacterium NRC-1 were identified. Such proteins could be interesting targets for understanding unique physiology of Halobacterium NRC-1. A group of proteins involved in various metabolic pathways were identified among the expressed proteins, suggesting these pathways were active at the time the cells were collected. This data containing a list of expressed proteins, their cellular locations, and biological functions could be used in future studies to investigate the interaction of the genes and proteins in relation to genetic or environmental perturbations.

  6. Development of the NRC`s Human Performance Investigation Process (HPIP). Volume 3, Development documentation

    SciTech Connect

    Paradies, M.; Unger, L.; Haas, P.; Terranova, M.

    1993-10-01

    The three volumes of this report detail a standard investigation process for use by US Nuclear Regulatory Commission (NRC) personnel when investigating human performance related events at nuclear power plants. The process, called the Human Performance Investigation Process (HPIP), was developed to meet the special needs of NRC personnel, especially NRC resident and regional inspectors. HPIP is a systematic investigation process combining current procedures and field practices, expert experience, NRC human performance research, and applicable investigation techniques. The process is easy to learn and helps NRC personnel perform better field investigations of the root causes of human performance problems. The human performance data gathered through such investigations provides a better understanding of the human performance issues that cause events at nuclear power plants. This document, Volume III, is a detailed documentation of the development effort and the pilot training program.

  7. Asteroseismic stellar activity relations

    NASA Astrophysics Data System (ADS)

    Bonanno, A.; Corsaro, E.; Karoff, C.

    2014-11-01

    Context. In asteroseismology an important diagnostic of the evolutionary status of a star is the small frequency separation which is sensitive to the gradient of the mean molecular weight in the stellar interior. It is thus interesting to discuss the classical age-activity relations in terms of this quantity. Moreover, as the photospheric magnetic field tends to suppress the amplitudes of acoustic oscillations, it is important to quantify the importance of this effect by considering various activity indicators. Aims: We propose a new class of age-activity relations that connects the Mt. Wilson S index and the average scatter in the light curve with the small frequency separation and the amplitude of the p-mode oscillations. Methods: We used a Bayesian inference to compute the posterior probability of various empirical laws for a sample of 19 solar-like active stars observed by the Kepler telescope. Results: We demonstrate the presence of a clear correlation between the Mt. Wilson S index and the relative age of the stars as indicated by the small frequency separation, as well as an anti-correlation between the S index and the oscillation amplitudes. We argue that the average activity level of the stars shows a stronger correlation with the small frequency separation than with the absolute age that is often considered in the literature. Conclusions: The phenomenological laws discovered in this paper have the potential to become new important diagnostics to link stellar evolution theory with the dynamics of global magnetic fields. In particular we argue that the relation between the Mt. Wilson S index and the oscillation amplitudes is in good agreement with the findings of direct numerical simulations of magneto-convection.

  8. NRC policy on future reactor designs

    SciTech Connect

    1985-07-01

    On April 13, 1983, the US Nuclear Regulatory Commission issued for public comment a ''Proposed Commission Policy Statement on Severe Accidents and Related Views on Nuclear Reactor Regulation'' (48 FR 16014). This report presents and discusses the Commission's final version of that policy statement now entitled, ''Policy Statement on Severe Reactor Accidents Regarding Future Designs and Existing Plants.'' It provides an overview of comments received from the public and the Advisory Committee on Reactor Safeguards and the staff response to these. In addition to the Policy Statement, the report discusses how the policies of this statement relate to other NRC programs including the Severe Accident Research Program; the implementation of safety measures resulting from lessons learned in the accident at Three Mile Island; safety goal development; the resolution of Unresolved Safety Issues and other Generic Safety Issues; and possible revisions of rules or regulatory requirements resulting from the Severe Accident Source Term Program. Also discussed are the main features of a generic decision strategy for resolving Regulatory Questions and Technical Issues relating to severe accidents; the development and regulatory use of new safety information; the treatment of uncertainty in severe accident decision making; and the development and implementation of a Systems Reliability Program for both existing and future plants to ensure that the realized level of safety is commensurate with the safety analyses used in regulatory decisions.

  9. Evaluation of NRC maintenance team inspection reports for managing aging

    SciTech Connect

    Fresco, A.; Gunther, W.

    1991-01-01

    A nuclear power plant's maintenance program is the principal vehicle through which age-related degradation is managed. Over the past two years, the NRC (Nuclear Regulatory Commission) has evaluated the maintenance program of every nuclear power plant in the U.S. The reports issued on these in-depth team inspections have been reviewed to ascertain the strengths and weaknesses of the programs as related to the need to understand and manage the effects of aging on nuclear power plant systems, structures, and components. Selected results of this review are presented in this paper, including examples of inspection and monitoring techniques successfully used by utilities to detect degradation due to aging. Attributes of plant maintenance programs where the NRC inspectors felt that improvement was needed to properly address the aging issue are also discussed. 6 refs., 1 tab.

  10. 10 CFR 2.1505 - Role of the NRC staff.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Role of the NRC staff. 2.1505 Section 2.1505 Energy... Legislative Hearings § 2.1505 Role of the NRC staff. The NRC staff shall be available to answer any Commission... officer may request without requiring the NRC staff to assume the role of an advocate. The NRC staff may...

  11. 76 FR 57006 - Proposed Generic Communications; Draft NRC Regulatory Issue Summary 2011-XX; NRC Regulation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ...-XX; NRC Regulation of Military Operational Radium-226; Reopening of Comment Period AGENCY: Nuclear... military operational Radium-226 for a 60-day public comment period that ended on September 6, 2011. The NRC... amended its regulations to include jurisdiction over discrete sources of radium-226,...

  12. Recommendations for NRC policy on shift scheduling and overtime at nuclear power plants

    SciTech Connect

    Lewis, P.M.

    1985-07-01

    This report contains the Pacific Northwest Laboratory's (PNL's) recommendations to the US Nuclear Regulatory Commission (NRC) for an NRC policy on shift scheduling and hours of work (including overtime) for control room operators and other safety-related personnel in nuclear power plants. First, it is recommended that NRC make three additions to its present policy on overtime: (1) limit personnel to 112 hours of work in a 14-day period, 192 hours in 28 days, and 2260 hours in one year; exceeding these limits would require plant manager approval; (2) add a requirement that licensees obtain approval from NRC if plant personnel are expected to exceed 72 hours of work in a 7-day period, 132 hours in 14 days, 228 hours in 28 days, and 2300 hours in one year; and (3) make the policy a requirement, rather than a nonbinding recommendation. Second, it is recommended that licensees be required to obtain NRC approval to adopt a routine 12-hour/day shift schedule. Third, it is recommended that NRC add several nonbinding recommendations concerning routine 8-hour/day schedules. Finally, because additional data can strengthen the basis for future NRC policy on overtime, five methods are suggested for collecting data on overtime and its effects. 44 refs., 10 tabs.

  13. NRC says integrated approach needed to understand, protect environment

    NASA Astrophysics Data System (ADS)

    Kolb, Charles E.; Loehr, Raymond C.; Gopnik, Morgan

    A recent study by the National Research Council (NRC) advocates a more comprehensive and integrated approach to our nation's environmental research and development (R&D) activities. Because we face environmental problems of unprecedented complexity, the study maintains that the traditional practice of studying isolated environmental problems and devising narrowly focused control or remediation strategies to manage them will no longer suffice.In the report, Building a Foundation for Sound Environmental Decisions [National Academy Press, 1997], an NRC committee highlighted the need for developing a deeper scientific understanding of ecosystems, as well as the sociological and economic aspects of human interactions with the environment. To achieve these goals, the committee recommended a core research agenda for the Environmental Protection Agency (EPA) that has three components.

  14. Update on the NAS-NRC Twin Registry.

    PubMed

    Page, William F

    2006-12-01

    The National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry is one of the oldest, national population-based twin registries in the United States. It consists of 15,924 white male twin pairs born in the years 1917 to 1927 (inclusive), both of whom served in the armed forces, mostly during World War II. This article updates activity in this registry since the earlier 2002 article in Twin Research. The results of clinically based studies on dementia, Parkinson's disease, age-related macular degeneration, and primary osteoarthritis were published, as well as articles based on previously collected questionnaire data on chronic fatigue syndrome, functional limitations, and healthy aging. In addition, risk factor studies are being planned to merge clinical data with earlier collected risk factor data from questionnaires. Examination data from the subset of National Heart, Lung, and Blood Institute (NHLBI) twins resulted in a number of articles, including the relationship of endogenous sex hormones to coronary heart disease and morphological changes in aging brain structures. The NEO Five-Factor Personality Inventory (a paper-and-pencil self-administered questionnaire) has been fielded for the first time. A push to consolidate the various data holdings of the registry is being made.

  15. NRC support for the Kalinin (VVER) probabilistic risk assessment

    SciTech Connect

    Bley, D.; Diamond, D.J.; Chu, T.L.; Azarm, A.; Pratt, W.T.; Johnson, D.; Szukiewicz, A.; Drouin, M.; El-Bassioni, A.; Su, T.M.

    1998-12-31

    The US Nuclear Regulatory Commission (NRC) and the Federal Nuclear and Radiation Safety Authority of the Russian Federation have been working together since 1994 to carry out a probabilistic risk assessment (PRA) of a VVER-1000 in the Russian Federation. This was a recognition by both parties that this technology has had a profound effect on the discipline of nuclear reactor safety in the West and that the technology should be transferred to others so that it can be applied to Soviet-designed plants. The NRC provided funds from the Agency for International Development and technical support primarily through Brookhaven National Laboratory and its subcontractors. The latter support was carried out through workshops, by documenting the methodology to be used in a set of guides, and through periodic review of the technical activity. The result of this effort to date includes a set of procedure guides, a draft final report on the Level 1 PRA for internal events (excluding internal fires and floods), and progress reports on the fire, flood, and seismic analysis. It is the authors belief that the type of assistance provided by the NRC has been instrumental in assuring a quality product and transferring important technology for use by regulators and operators of Soviet-designed reactors. After a thorough review, the report will be finalized, lessons learned will be applied in the regulatory and operational regimes in the Russian Federation, and consideration will be given to supporting a containment analysis in order to complete a simplified Level 2 PRA.

  16. NRC SUPPORT FOR THE KALININ (VVER) PROBABILISTIC RISK ASSESSMENT

    SciTech Connect

    BLEY,D.; DIAMOND,D.J.; CHU,T.L.; AZARM,A.; PRATT,W.T.; JOHNSON,D.; SZUKIEWICZ,A.; DROUIN,M.; EL-BASSIONI,A.; SU,T.M.

    1998-10-26

    The US Nuclear Regulatory Commission (NRC) and the Federal Nuclear and Radiation Safety Authority of the Russian Federation have been working together since 1994 to carry out a probabilistic risk assessment (PRA) of a VVER-1000 in the Russian Federation. This was a recognition by both parties that this technology has had a profound effect on the discipline of nuclear reactor safety in the West and that the technology should be transferred to others so that it can be applied to Soviet-designed plants. The NRC provided funds from the Agency for International Development and technical support primarily through Brookhaven National Laboratory and its subcontractors. The latter support was carried out through workshops, by documenting the methodology to be used in a set of guides, and through periodic review of the technical activity. The result of this effort to date includes a set of procedure guides, a draft final report on the Level 1 PRA for internal events (excluding internal fires and floods), and progress reports on the fire, flood, and seismic analysis. It is the authors belief that the type of assistance provided by the NRC has been instrumental in assuring a quality product and transferring important technology for use by regulators and operators of Soviet-designed reactors. After a thorough review, the report will be finalized, lessons learned will be applied in the regulatory and operational regimes in the Russian Federation, and consideration will be given to supporting a containment analysis in order to complete a simplified Level 2 PRA.

  17. The National Research Center on the Gifted and Talented (NRC/GT) Newsletter, June 1991-Winter 1997.

    ERIC Educational Resources Information Center

    Gubbins, E. Jean, Ed.; Siegle, Del L., Ed.

    1997-01-01

    These 15 newsletters from the National Research Center on the Gifted and Talented (NRC/GT) contain the following articles: (1) "National Research Needs Assessment Process" (Brian D. Reid); (2) "NRC/GT: Update of Year 2 Activities" (E. Jean Gubbins); (3) "Parents: Their Impact on Gifted Adolescents" (Julie L. Sherman);…

  18. NRC comprehensive records disposition schedule. Revision 3

    SciTech Connect

    1998-02-01

    Title 44 US Code, ``Public Printing and Documents,`` regulations issued by the General Service Administration (GSA) in 41 CFR Chapter 101, Subchapter B, ``Management and Use of Information and Records,`` and regulations issued by the National Archives and Records Administration (NARA) in 36 CFR Chapter 12, Subchapter B, ``Records Management,`` require each agency to prepare and issue a comprehensive records disposition schedule that contains the NARA approved records disposition schedules for records unique to the agency and contains the NARA`s General Records Schedules for records common to several or all agencies. The approved records disposition schedules specify the appropriate duration of retention and the final disposition for records created or maintained by the NRC. NUREG-0910, Rev. 3, contains ``NRC`s Comprehensive Records Disposition Schedule,`` and the original authorized approved citation numbers issued by NARA. Rev. 3 incorporates NARA approved changes and additions to the NRC schedules that have been implemented since the last revision dated March, 1992, reflects recent organizational changes implemented at the NRC, and includes the latest version of NARA`s General Records Schedule (dated August 1995).

  19. NRC/AMRMC Resident Research Associateship Program

    DTIC Science & Technology

    2013-05-01

    Intravital Microscopy was successfully employed for investigating EG sheddÍng in hemorrhagic shock/resuscitation for the very first time; 2) Intravital ...during Hemorrhagic Shock in Rats using Intravital Microscopy. Submitted to Microvascular Research, 2012 (under review). FINAL REPORT Laboratory or...Glycocalyx using Intravital Microscopy. In Preparation. IO) PATENT OR COPYRIGHT APPLICATIONS KESULTING FROM NRC ASSOCIATESHIP KESEARCH Provide titles

  20. 48 CFR 2009.100 - NRC policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., Restrictions on Former Officers, Employees, and Elected Officials of the Executive and Legislative Branches. ... Government employees performing services for NRC as experts, advisors, consultants, or members of advisory... interest of the Government to contract with an individual or firm described in paragraphs (a) and (b)...

  1. 48 CFR 2009.100 - NRC policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., Restrictions on Former Officers, Employees, and Elected Officials of the Executive and Legislative Branches. ... Government employees performing services for NRC as experts, advisors, consultants, or members of advisory... interest of the Government to contract with an individual or firm described in paragraphs (a) and (b)...

  2. 76 FR 40282 - Proposed Generic Communications; Draft NRC Regulatory Issue Summary 2011-XX; NRC Regulation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... use in traditional military operations. This RIS resolves an existing ambiguity by clarifying that... continue their existing role under CERCLA for these sites. However, NRC would reserve the option...

  3. 48 CFR 2009.570 - NRC organizational conflicts of interest.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NRC organizational... COMMISSION COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Organizational Conflicts of Interest 2009.570 NRC organizational conflicts of interest. ...

  4. 75 FR 6063 - Availability of NRC Open Government Web Site

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... COMMISSION Availability of NRC Open Government Web Site AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Availability of Open Government Web site for Online Public Comments. SUMMARY: This notice, which... Nuclear Regulatory Commission's (NRC) Open Government Web site ( http://www.nrc.gov/open ) will be...

  5. NRC staff site characterization analysis of the Department of Energy`s Site Characterization Plan, Yucca Mountain Site, Nevada

    SciTech Connect

    1989-08-01

    This Site Characterization Analysis (SCA) documents the NRC staff`s concerns resulting from its review of the US Department of Energy`s (DOE`s) Site Characterization Plan (SCP) for the Yucca Mountain site in southern Nevada, which is the candidate site selected for characterization as the nation`s first geologic repository for high-level radioactive waste. DOE`s SCP explains how DOE plans to obtain the information necessary to determine the suitability of the Yucca Mountain site for a repository. NRC`s specific objections related to the SCP, and major comments and recommendations on the various parts of DOE`s program, are presented in SCA Section 2, Director`s Comments and Recommendations. Section 3 contains summaries of the NRC staff`s concerns for each specific program, and Section 4 contains NRC staff point papers which set forth in greater detail particular staff concerns regarding DOE`s program. Appendix A presents NRC staff evaluations of those NRC staff Consultation Draft SCP concerns that NRC considers resolved on the basis of the SCP. This SCA fulfills NRC`s responsibilities with respect to DOE`s SCP as specified by the Nuclear Waste Policy Act (NWPA) and 10 CFR 60.18. 192 refs., 2 tabs.

  6. Development of the NRC`s Human Performance Investigation Process (HPIP). Volume 2, Investigators`s Manual

    SciTech Connect

    Paradies, M.; Unger, L.; Haas, P.; Terranova, M.

    1993-10-01

    The three volumes of this report detail a standard investigation process for use by US Nuclear Regulatory Commission (NRC) personnel when investigating human performance related events at nuclear power plants. The process, called the Human Performance Investigation Process (HPIP), was developed to meet the special needs of NRC personnel, especially NRC resident and regional inspectors. HPIP is a systematic investigation process combining current procedures and field practices, expert experience, NRC human performance research, and applicable investigation techniques. The process is easy to learn and helps NRC personnel perform better field investigations of the root causes of human performance problems. The human performance data gathered through such investigations provides a better understanding of the human performance issues that cause event at nuclear power plants. This document, Volume II, is a field manual for use by investigators when performing event investigations. Volume II includes the HPIP Procedure, the HPIP Modules, and Appendices that provide extensive documentation of each investigation technique.

  7. NRC/AMRMC Resident Research Associateship Program

    DTIC Science & Technology

    2016-04-27

    accepted. A total of 13 Associates ended their tenure during the reporting period and of these 9 submitted a final report. The productivity of these... Associates is listed in the technical report. 15. SUBJECT TERMS- Associateship program, post-doc, awards 16. SECURITY CLASSIFICATION OF: 17. LIMITATION...applicant during the current reporting period is shown in Table 1. For Associates beginning or continuing tenure, the NRC provided the administrative

  8. NRC; Smog control efforts off mark

    SciTech Connect

    Not Available

    1992-01-06

    This paper reports that the National Research Council says the U.S. regulatory programs to control smog may have been misdirected the past 20 years, and more emphasis needs to be placed on limiting nitrogen oxide emissions. An NRC study the ozone control efforts have focused mainly on controlling volatile organic compounds (VOC) emissions. However, in many parts of the country controlling emissions of nitrogen oxides would be more effective, it the, noting VOCs and nitrogen oxides are precursors of ozone.

  9. Au Fixed Point Development at NRC

    NASA Astrophysics Data System (ADS)

    Dedyulin, S. N.; Gotoh, M.; Todd, A. D. W.

    2017-04-01

    Two Au fixed points filled using metal of different nominal purities in carbon crucibles have been developed at the National Research Council Canada (NRC). The primary motivation behind this project was to provide the means for direct thermocouple calibrations at the Au freezing point (1064.18°C). Using a Au fixed point filled with the metal of maximum available purity [99.9997 % pure according to glow discharge mass spectroscopy (GDMS)], multiple freezing plateaus were measured in a commercial high-temperature furnace. Four Pt/Pd thermocouples constructed and calibrated in-house were used to measure the freezing plateaus. From the calibration at Sn, Zn, Al and Ag fixed points, the linear deviation function from the NIST-IMGC reference function (IEC 62460:2008 Standard) was determined and extrapolated to the freezing temperature of Au. For all the Pt/Pd thermocouples used in this study, the measured EMF values agree with the extrapolated values within expanded uncertainty, thus substantiating the use of 99.9997 % pure Au fixed point cell for thermocouple calibrations at NRC. Using the Au fixed point filled with metal of lower purity (99.99 % pure according to GDMS), the effect of impurities on the Au freezing temperature measured with Pt/Pd thermocouple was further investigated.

  10. Web-based training course for evaluating radiological dose assessment in NRC's license termination process.

    PubMed

    Lepoire, D; Richmond, P; Cheng, J-J; Kamboj, S; Arnish, J; Chen, S Y; Barr, C; McKenney, C

    2008-08-01

    As part of the requirement for terminating the licenses of nuclear power plants or other nuclear facilities, license termination plans or decommissioning plans are submitted by the licensee to the U.S. Nuclear Regulatory Commission (NRC) for review and approval. Decommissioning plans generally refer to the decommissioning of nonreactor facilities, while license termination plans specifically refer to the decommissioning of nuclear reactor facilities. To provide a uniform and consistent review of dose modeling aspects of these plans and to address NRC-wide knowledge management issues, the NRC, in 2006, commissioned Argonne National Laboratory to develop a Web-based training course on reviewing radiological dose assessments for license termination. The course, which had first been developed in 2005 to target specific aspects of the review processes for license termination plans and decommissioning plans, evolved from a live classroom course into a Web-based training course in 2006. The objective of the Web-based training course is to train NRC staff members (who have various relevant job functions and are located at headquarters, regional offices, and site locations) to conduct an effective review of dose modeling in accordance with the latest NRC guidance, including NUREG-1757, Volumes 1 and 2. The exact size of the staff population who will receive the training has not yet been accurately determined but will depend on various factors such as the decommissioning activities at the NRC. This Web-based training course is designed to give NRC staff members modern, flexible access to training. To this end, the course is divided into 16 modules: 9 core modules that deal with basic topics, and 7 advanced modules that deal with complex issues or job-specific topics. The core and advanced modules are tailored to various NRC staff members with different job functions. The Web-based system uses the commercially available software Articulate, which incorporates audio, video

  11. New security measures are proposed for N-plants: Insider Rule package is issued by NRC

    SciTech Connect

    Not Available

    1984-09-01

    New rules proposed by the Nuclear Regulatory Commission (NRC) will require background investigations and psychological assessments of new job candidates and continual monitoring of the behavior of all power plant workers with access to sensitive areas. Licensees will have to submit an ''access authorization'' program for approval describing how they will conduct these security activities. The employee checks will go back five years to examine credit, educational, and criminal histories. Implementation of the rules could involve the Edison Electric Institute as an intermediary to funnel criminal checks from the Justice Department and FBI. The NRC is also considering a clarification of areas designated as ''vital'' because current designations may be too strict.

  12. Marine Biology Activities. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Pauls, John

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  13. Design basis for the NRC Operations Center

    SciTech Connect

    Lindell, M.K.; Wise, J.A.; Griffin, B.N.; Desrosiers, A.E.; Meitzler, W.D.

    1983-05-01

    This report documents the development of a design for a new NRC Operations Center (NRCOC). The project was conducted in two phases: organizational analysis and facility design. In order to control the amount of traffic, congestion and noise within the facility, it is recommended that information flow in the new NRCOC be accomplished by means of an electronic Status Information Management System. Functional requirements and a conceptual design for this system are described. An idealized architectural design and a detailed design program are presented that provide the appropriate amount of space for operations, equipment and circulation within team areas. The overall layout provides controlled access to the facility and, through the use of a zoning concept, provides each team within the NRCOC the appropriate balance of ready access and privacy determined from the organizational analyses conducted during the initial phase of the project.

  14. 75 FR 20009 - Development of NRC's Safety Culture Policy Statement: Cancellation of Public Workshops Scheduled...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-16

    ... COMMISSION Development of NRC's Safety Culture Policy Statement: Cancellation of Public Workshops Scheduled... forging a consensus around the objectives, strategies, activities and measures that enhance safety culture... culture common terminology effort comprised of: (1) Development of a common safety culture definition; and...

  15. 10 CFR 10.25 - NRC Hearing Counsel.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false NRC Hearing Counsel. 10.25 Section 10.25 Energy NUCLEAR... NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.25 NRC Hearing Counsel. (a) Hearing Counsel assigned pursuant to § 10.24 will, before the scheduling of the hearing, review...

  16. 10 CFR 10.25 - NRC Hearing Counsel.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false NRC Hearing Counsel. 10.25 Section 10.25 Energy NUCLEAR... NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.25 NRC Hearing Counsel. (a) Hearing Counsel assigned pursuant to § 10.24 will, before the scheduling of the hearing, review...

  17. 10 CFR 10.25 - NRC Hearing Counsel.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false NRC Hearing Counsel. 10.25 Section 10.25 Energy NUCLEAR... NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.25 NRC Hearing Counsel. (a) Hearing Counsel assigned pursuant to § 10.24 will, before the scheduling of the hearing, review...

  18. 10 CFR 10.25 - NRC Hearing Counsel.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false NRC Hearing Counsel. 10.25 Section 10.25 Energy NUCLEAR... NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.25 NRC Hearing Counsel. (a) Hearing Counsel assigned pursuant to § 10.24 will, before the scheduling of the hearing, review...

  19. 10 CFR 10.25 - NRC Hearing Counsel.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false NRC Hearing Counsel. 10.25 Section 10.25 Energy NUCLEAR... NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.25 NRC Hearing Counsel. (a) Hearing Counsel assigned pursuant to § 10.24 will, before the scheduling of the hearing, review...

  20. 10 CFR 1.55 - Establishment of official NRC flag.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Establishment of official NRC flag. 1.55 Section 1.55 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION NRC Seal and Flag... dark blue field with a gold fringe....

  1. 10 CFR 1.55 - Establishment of official NRC flag.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Establishment of official NRC flag. 1.55 Section 1.55 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION NRC Seal and Flag... dark blue field with a gold fringe. ...

  2. 10 CFR 1.55 - Establishment of official NRC flag.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Establishment of official NRC flag. 1.55 Section 1.55 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION NRC Seal and Flag... dark blue field with a gold fringe. ...

  3. 10 CFR 1.55 - Establishment of official NRC flag.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Establishment of official NRC flag. 1.55 Section 1.55 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION NRC Seal and Flag... dark blue field with a gold fringe. ...

  4. 10 CFR 1.55 - Establishment of official NRC flag.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Establishment of official NRC flag. 1.55 Section 1.55 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION NRC Seal and Flag... dark blue field with a gold fringe. ...

  5. 10 CFR 72.238 - Issuance of an NRC Certificate of Compliance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Issuance of an NRC Certificate of Compliance. 72.238 Section 72.238 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS...

  6. 10 CFR 72.238 - Issuance of an NRC Certificate of Compliance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Issuance of an NRC Certificate of Compliance. 72.238 Section 72.238 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS...

  7. Regulatory and Financial Reform of Federal Research Policy: Recommendations to the NRC Committee on Research Universities

    ERIC Educational Resources Information Center

    Association of American Universities, 2011

    2011-01-01

    At the request of the National Research Council (NRC) Committee on Research Universities, the Council on Governmental Relations (COGR), the Association of American Universities (AAU), and the Association of Public and Land-grant Universities (APLU) have assembled a set of ten recommendations for regulatory reform that would improve research…

  8. 10 CFR 72.238 - Issuance of an NRC Certificate of Compliance.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Issuance of an NRC Certificate of Compliance. 72.238 Section 72.238 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C...

  9. 10 CFR 72.238 - Issuance of an NRC Certificate of Compliance.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Issuance of an NRC Certificate of Compliance. 72.238 Section 72.238 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C...

  10. 10 CFR 72.238 - Issuance of an NRC Certificate of Compliance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Issuance of an NRC Certificate of Compliance. 72.238 Section 72.238 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C...

  11. Overview of NRC's Regulatory Perspective on Performance Confirmation

    NASA Astrophysics Data System (ADS)

    Fedors, R. W.; Pohle, J. A.

    2007-12-01

    Regulations governing the disposal of high-level radioactive waste at 10 CFR Part 63, Subpart F, require the implementation of a Performance Confirmation Program for a geologic repository at Yucca Mountain, Nevada. The goals of the Performance Confirmation Program are to confirm that the (i) actual subsurface conditions and potential changes in these conditions during construction and waste emplacement operations are within the limits assumed during the licensing review, and (ii) natural and engineered barriers are functioning as intended and anticipated. For a license application for construction authorization, only a plan is required by the regulations. Proposed activities might include (i) monitoring the repository environment, both engineered and natural components, (ii) field and laboratory investigations under more controlled conditions to better understand processes, and (iii) scientific and programmatic evaluation of the data to support operational decisionmaking and guide adaptive design alterations. NRC review of vadose zone monitoring methods revealed limitations in current technological solutions such that many presently available hydro-environmental sensors would likely not be suitable for long- term, deep-subsurface, fractured rock monitoring activities, particularly with respect to the temperatures and radiation environment that will occur near or within waste emplacement drifts. Sensor deployment strategies will also have to be developed considering the repository environment. Thus, achieving the goals of the performance confirmation program could be affected by limits on sensor capabilities or on an as yet to be proposed sensor deployment strategy. A performance confirmation program implemented over a lengthy operational period allows for future evolution and development of sensors and strategies to further advance the collection of information relevant to processes important for performance of the potential repository at Yucca Mountain. The NRC

  12. Beaches. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Marrett, Andrea

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  13. Whales. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Jones, Claire

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  14. Waterbirds. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Russell, Barbara

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  15. Tides. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Marrett, Andrea

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  16. Strategic Planning and NRC Decadal Survey Experience

    NASA Astrophysics Data System (ADS)

    Lautenbacher, C. C., Jr.

    2015-12-01

    Strategic planning exercises are routinely undertaken by a wide variety of organizations that span the private, public and academic sectors and with a wide variety of corporate goals. It is difficult to single out best procedures as the purposes of strategic planning are as varied as the organizations. As a former head of a governmental agency that requested such a NRC study, namely the first "Earth Sciences and Applications from Space" study, I will examine the process, provide my definitions and assessments of the good and the not-so-good, and compare to my experiences with other similar strategic planning exercises during my Navy, NOAA, and private sector careers. I find that there is always room for improvement, but there is no one process or procedure that can guarantee success. Overarching initial considerations that can position the effort for overall "success" will be defined and applied to the recent NSC Study: "Sea Change: 2015-2025 Decadal Survey of Ocean Science", for which I was neither an initiator nor a participant, but a very interested observer.

  17. NRC hopes to discourage lengthy onsite storage

    SciTech Connect

    Not Available

    1993-03-01

    Now it has become clear why last year's partial voiding of the Low-Level Waste Policy Amendments Act was seen as significant in some quarters. On June 19, 1992, the US Supreme Court ruled that the passage requiring states to take title to LLW produced within their borders was unconstitutional (NN, July 1992, p. 17). This did not change the facts that LLW is still being generated, and that interstate compacts with licensed disposal sites are now empowered to refuse LLW from outside the compacts. Still, state officials had a reason to be relieved-because they knew that the Nuclear Regulatory Commission was at work on a regulation that would have made them take title to LLW, at a radwaste generator's request, at any time after January 1, 1996, if the state did not have access to a licensed disposal site. The court ruling has forced the NRC to take this passage out of the proposal, but the agency has still gone ahead and published draft amendments intended to establish long-term onsite storage as the last resort option for LLW management.

  18. Safety team assessments at NRC (Nuclear Regulatory Commission)-licensed fuel facilities

    SciTech Connect

    Sjoblom, G.L.

    1988-01-01

    Following the hydraulic rupture of a UF cylinder at the Sequoyah Fuels Facility on January 4, 1986, the US Nuclear Regulatory Commission's (NRC's) executive director for operations (EDO) established an augmented inspection team to investigate the accident. The investigation is reported in NUREG-1179. The EDO then formed a lessons-learned group to report on the action NRC might reasonably take to prevent similar accidents. The group's recommendations are reported in NUREG-1198. In addition, the EDO formed an independent materials safety regulation review study group (MSRRSG) to review the licensing and inspection program for NRC-licensed fuel cycle and materials facilities. During the same period of time that the MSRRSG report was being prepared and evaluated, the staff undertook an independent action to assess operational safety at each of the 12 major fuel facilities licensed by the NRC. The facilities included the 2 facilities producing uranium hexafluoride, the 7 facilities producing commercial nuclear reactor fuel, and the 3 facilities producing naval reactor fuel. The most important safety issues identified as needing attention by licensees were in the areas of fire protection, chemical hazards identification and mitigation, management controls or quality assurance, safety-related instrumentation and maintenance, and emergency preparedness.

  19. Functional analysis of type 1 isopentenyl diphosphate isomerase from Halobacterium sp. NRC-1.

    PubMed

    Hoshino, Takeshi; Eguchi, Tadashi

    2007-10-01

    Here we report the characterization of the type-1 isopentenyl diphosphate isomerase derived from Halobacterium sp. NRC-1. The expressed purified enzyme showed maximum isomerase activity in the presence of 1 M NaCl at 37 degrees C at pH 6.0. This type-1 enzyme appears to be the first for which the Co2+ ion is required for activity.

  20. 10 CFR 1.57 - Use of NRC flag.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... speaker's platform, the U.S. flag must occupy the position of honor and be placed at the speaker's right as he or she faces the audience, and the NRC flag must be placed at the speaker's left. ...

  1. Regulatory decision with EPA/NRC/DOE/State Session (Panel)

    SciTech Connect

    O`Donnell, E.

    1995-12-31

    This panel will cover the Nuclear Regulatory Commission`s (NRC) proposed radiation limits in the Branch Technical Position on Low-Level Radioactive Waste Performance Assessment and the Environmental Protection Agency`s (EPA) draft regulation in Part 193. Representatives from NRC and EPA will discuss the inconsistencies in these two regulations. DOE and state representatives will discuss their perspective on how these regulations will affect low-level radioactive waste performance assessments.

  2. Initial demonstration of the NRC`s capability to conduct a performance assessment for a High-Level Waste Repository

    SciTech Connect

    Codell, R.; Eisenberg, N.; Fehringer, D.; Ford, W.; Margulies, T.; McCartin, T.; Park, J.; Randall, J.

    1992-05-01

    In order to better review licensing submittals for a High-Level Waste Repository, the US Nuclear Regulatory Commission staff has expanded and improved its capability to conduct performance assessments. This report documents an initial demonstration of this capability. The demonstration made use of the limited data from Yucca Mountain, Nevada to investigate a small set of scenario classes. Models of release and transport of radionuclides from a repository via the groundwater and direct release pathways provided preliminary estimates of releases to the accessible environment for a 10,000 year simulation time. Latin hypercube sampling of input parameters was used to express results as distributions and to investigate model sensitivities. This methodology demonstration should not be interpreted as an estimate of performance of the proposed repository at Yucca Mountain, Nevada. By expanding and developing the NRC staff capability to conduct such analyses, NRC would be better able to conduct an independent technical review of the US Department of Energy (DOE) licensing submittals for a high-level waste (HLW) repository. These activities were divided initially into Phase 1 and Phase 2 activities. Additional phases may follow as part of a program of iterative performance assessment at the NRC. The NRC staff conducted Phase 1 activities primarily in CY 1989 with minimal participation from NRC contractors. The Phase 2 activities were to involve NRC contractors actively and to provide for the transfer of technology. The Phase 2 activities are scheduled to start in CY 1990, to allow Sandia National Laboratories to complete development and transfer of computer codes and the Center for Nuclear Waste Regulatory Analyses (CNWRA) to be in a position to assist in the acquisition of the codes.

  3. 10 CFR 81.13 - Publication of NRC inventions available for licensing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Publication of NRC inventions available for licensing. 81... GRANTING OF PATENT LICENSES Nrc-Owned Inventions-Patents and Applications § 81.13 Publication of NRC inventions available for licensing. (a) The Commission will have published periodically a list of the NRC...

  4. 10 CFR 9.37 - Fees for search and review of agency records by NRC personnel.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Fees for search and review of agency records by NRC... Regulations § 9.37 Fees for search and review of agency records by NRC personnel. The NRC will charge the following hourly rates for search and review of agency records by NRC personnel: (a) Clerical search...

  5. 10 CFR 9.37 - Fees for search and review of agency records by NRC personnel.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Fees for search and review of agency records by NRC... Regulations § 9.37 Fees for search and review of agency records by NRC personnel. The NRC will charge the following hourly rates for search and review of agency records by NRC personnel: (a) Clerical search...

  6. 10 CFR 9.37 - Fees for search and review of agency records by NRC personnel.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Fees for search and review of agency records by NRC... Regulations § 9.37 Fees for search and review of agency records by NRC personnel. The NRC will charge the following hourly rates for search and review of agency records by NRC personnel: (a) Clerical search and...

  7. 10 CFR 9.37 - Fees for search and review of agency records by NRC personnel.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Fees for search and review of agency records by NRC... Regulations § 9.37 Fees for search and review of agency records by NRC personnel. The NRC will charge the following hourly rates for search and review of agency records by NRC personnel: (a) Clerical search and...

  8. 10 CFR 9.37 - Fees for search and review of agency records by NRC personnel.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Fees for search and review of agency records by NRC... Regulations § 9.37 Fees for search and review of agency records by NRC personnel. The NRC will charge the following hourly rates for search and review of agency records by NRC personnel: (a) Clerical search and...

  9. Climate change and related activities

    SciTech Connect

    Not Available

    1992-10-01

    The production and consumption of energy contributes to the concentration of greenhouse gases in the atmosphere and is the focus of other environmental concerns as well. Yet the use of energy contributes to worldwide economic growth and development. If we are to achieve environmentally sound economic growth, we must develop and deploy energy technologies that contribute to global stewardship. The Department of Energy carries out an aggressive scientific research program to address some of the key uncertainties associated with the climate change issue. Of course, research simply to study the science of global climate change is not enough. At the heart of any regime of cost-effective actions to address the possibility of global climate change will be a panoply of new technologies-technologies both to provide the services we demand and to use energy more efficiently than in the past. These, too, are important areas of responsibility for the Department. This report is a brief description of the Department`s activities in scientific research, technology development, policy studies, and international cooperation that are directly related to or have some bearing on the issue of global climate change.

  10. Climate change and related activities

    SciTech Connect

    Not Available

    1992-01-01

    The production and consumption of energy contributes to the concentration of greenhouse gases in the atmosphere and is the focus of other environmental concerns as well. Yet the use of energy contributes to worldwide economic growth and development. If we are to achieve environmentally sound economic growth, we must develop and deploy energy technologies that contribute to global stewardship. The Department of Energy carries out an aggressive scientific research program to address some of the key uncertainties associated with the climate change issue. Of course, research simply to study the science of global climate change is not enough. At the heart of any regime of cost-effective actions to address the possibility of global climate change will be a panoply of new technologies-technologies both to provide the services we demand and to use energy more efficiently than in the past. These, too, are important areas of responsibility for the Department. This report is a brief description of the Department's activities in scientific research, technology development, policy studies, and international cooperation that are directly related to or have some bearing on the issue of global climate change.

  11. NRC staff review of licensee responses to pressure-locking and thermal-binding issue

    SciTech Connect

    Rathbun, H.J.

    1996-12-01

    Commercial nuclear power plant operating experience has indicated that pressure locking and thermal binding represent potential common mode failure mechanisms that can cause safety-related power-operated gate valves to fail in the closed position, thus rendering redundant safety-related systems incapable of performing their safety functions. In Generic Letter (GL) 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves,{close_quotes} the U.S. Nuclear Regulatory Commission (NRC) staff requested that nuclear power plant licensees take certain actions to ensure that valves susceptible to pressure locking or thermal binding are capable of performing their safety functions within the current licensing bases of the facility. The NRC staff has received summary information from licensees in response to GL 95-07 describing actions they have taken to prevent the occurrence of pressure locking and thermal binding. The NRC staff has developed a systematic process to help ensure uniform and consistent review of licensee submittals in response to GL 95-07.

  12. Climate change and related activities

    SciTech Connect

    Not Available

    1992-01-01

    The greenhouse'' process regulates the Earth's climate at a level to sustain life, making our planet unique. The term climate'' refers not only to temperature, but also to the entire system of precipitation, cloudiness, and winds, as well as to the distribution of these features in space and time. The production and consumption of energy contributes to the concentration of greenhouse gases in the atmosphere and is the focus of other environmental concerns as well. Yet the use of energy contributes to worldwide economic growth and development. It we are to achieve environmentally sound economic growth, we must develop and deploy energy technologies that contribute to global stewardship. Global climate change is a significant issue for the US Department of Energy (DOE) because greenhouse gases are emitted from the production and use of fossil fuels. Energy use and production now contribute more than half of the total manmade emissions on a global basis. DOE carries out an aggressive scientific research program to address some of the key uncertainties associated with the climate change issue. Of course, research simply to study the science of global climate change is not enough. At the heart of any regime of cost-effective actions to address the possibility of global climate change will be a panoply of new technologies -- technologies both to provide the services we demand and to use energy more efficiently than in the past. These, too, are important areas of responsibility for DOE. This report is a brief description of DOE's activities in scientific research, technology development, policy studies, and international cooperation that are directly related to or have some bearing on the issue of global climate change.

  13. Climate change and related activities

    SciTech Connect

    Not Available

    1992-03-01

    The ``greenhouse`` process regulates the Earth`s climate at a level to sustain life, making our planet unique. The term ``climate`` refers not only to temperature, but also to the entire system of precipitation, cloudiness, and winds, as well as to the distribution of these features in space and time. The production and consumption of energy contributes to the concentration of greenhouse gases in the atmosphere and is the focus of other environmental concerns as well. Yet the use of energy contributes to worldwide economic growth and development. It we are to achieve environmentally sound economic growth, we must develop and deploy energy technologies that contribute to global stewardship. Global climate change is a significant issue for the US Department of Energy (DOE) because greenhouse gases are emitted from the production and use of fossil fuels. Energy use and production now contribute more than half of the total manmade emissions on a global basis. DOE carries out an aggressive scientific research program to address some of the key uncertainties associated with the climate change issue. Of course, research simply to study the science of global climate change is not enough. At the heart of any regime of cost-effective actions to address the possibility of global climate change will be a panoply of new technologies -- technologies both to provide the services we demand and to use energy more efficiently than in the past. These, too, are important areas of responsibility for DOE. This report is a brief description of DOE`s activities in scientific research, technology development, policy studies, and international cooperation that are directly related to or have some bearing on the issue of global climate change.

  14. An overview of fuel-coolant interactions (FCI) research at NRC

    SciTech Connect

    Basu, S.; Speis, T.P.

    1996-03-01

    An overview of the fuel-coolant interactions (FCI) research programs sponsored by the U.S. Nuclear Regulatory Commission (NRC) is presented in this paper. A historical perspective of the program is provided with particular reference to in-vessel steam explosion and its consequences on the reactor pressure vessel and the containment integrity. Emphasis is placed on research in the last decade involving fundamentals of FCI phenomenology, namely, premixing, triggering, propagation, and energetics. The status of the current understanding of in-vessel steam explosion-induced containment failure (alpha-mode) issue, and other FCI issues related to reactor vessel and containment integrity are reported, including the extensive review and discussion of these issues at the recently held second Steam Explosion Review Group Workshop (SERG-2). Ongoing NRC research programs are discussed in detail. Future research programs including those recommended at the SERG-2 workshop are outlined.

  15. International Activities Related to Pesticides

    EPA Pesticide Factsheets

    Regulating pesticides involves many international issues and working with our regulatory partners in other countries. Learn about EPA's activities, upcoming meetings and workshops, and various regulatory issues.

  16. Congress, NRC mull utility access to FBI criminal files

    SciTech Connect

    Ultroska, D.

    1984-08-01

    Experiences at Alabama Power Company and other nuclear utilities have promped a request for institutionalizing security checks of personnel in order to eliminated convicted criminals and drug users. The Nuclear Regulatory Commission (NRC), which could provide FBI criminal history information by submitting fingerprints, does not do so, and would require new legislation to take on that duty. Believing that current malevolent employees can be managed with existing procedures, NRC allows criminal background checks only on prospective employees in order to avoid a negative social impact on personnel. Legislation to transfer criminal histories to nuclear facilities is now pending, and NRC is leaning toward a request for full disclosure, partly because of terrorist threats and partly to save manpower time and costs in reviewing case histories.

  17. Expression and purification of toxic anti-breast cancer p28-NRC chimeric protein

    PubMed Central

    Soleimani, Meysam; Mirmohammad-Sadeghi, Hamid; Sadeghi-Aliabadi, Hojjat; Jahanian-Najafabadi, Ali

    2016-01-01

    Background: Chimeric proteins consisting of a targeting moiety and a cytotoxic moiety are now under intense research focus for targeted therapy of cancer. Here, we report cloning, expression, and purification of such a targeted chimeric protein made up of p28 peptide as both targeting and anticancer moiety fused to NRC peptide as a cytotoxic moiety. However, since the antimicrobial activity of the NRC peptide would intervene expression of the chimeric protein in Escherichia coli, we evaluated the effects of two fusion tags, that is, thioredoxin (Trx) and 6x-His tags, and various expression conditions, on the expression of p28-NRC chimeric protein. Materials and Methods: In order to express the chimeric protein with only 6x-His tag, pET28 expression plasmid was used. Cloning in pET32 expression plasmid was performed to add both Trx and 6x-His tags to the chimeric protein. Expression of the chimeric protein with both plasmids was evaluated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot analysis following optimization of expression conditions and host strains. Results: Expression of the chimeric protein in pET28a was performed. However, expression yield of the chimeric protein was low. Optimization of culture conditions and host strains led to reasonable expression yield of the toxic chimeric protein in pET32a vector. In cases of both plasmids, approximately 10 kDa deviation of the apparent molecular weight from the theoretical one was seen in SDS-PAGE of purified chimeric proteins. Conclusions: The study leads to proper expression and purification yield of p28-NRC chimeric protein with Trx tag following optimizing culture conditions and host strains. PMID:27169101

  18. Fungal communication requires the MAK-2 pathway elements STE-20 and RAS-2, the NRC-1 adapter STE-50 and the MAP kinase scaffold HAM-5.

    PubMed

    Dettmann, Anne; Heilig, Yvonne; Valerius, Oliver; Ludwig, Sarah; Seiler, Stephan

    2014-11-01

    Intercellular communication is critical for the survival of unicellular organisms as well as for the development and function of multicellular tissues. Cell-to-cell signaling is also required to develop the interconnected mycelial network characteristic of filamentous fungi and is a prerequisite for symbiotic and pathogenic host colonization achieved by molds. Somatic cell-cell communication and subsequent cell fusion is governed by the MAK-2 mitogen activated protein kinase (MAPK) cascade in the filamentous ascomycete model Neurospora crassa, yet the composition and mode of regulation of the MAK-2 pathway are currently unclear. In order to identify additional components involved in MAK-2 signaling we performed affinity purification experiments coupled to mass spectrometry with strains expressing functional GFP-fusion proteins of the MAPK cascade. This approach identified STE-50 as a regulatory subunit of the Ste11p homolog NRC-1 and HAM-5 as cell-communication-specific scaffold protein of the MAPK cascade. Moreover, we defined a network of proteins consisting of two Ste20-related kinases, the small GTPase RAS-2 and the adenylate cyclase capping protein CAP-1 that function upstream of the MAK-2 pathway and whose signals converge on the NRC-1/STE-50 MAP3K complex and the HAM-5 scaffold. Finally, our data suggest an involvement of the striatin interacting phosphatase and kinase (STRIPAK) complex, the casein kinase 2 heterodimer, the phospholipid flippase modulators YPK-1 and NRC-2 and motor protein-dependent vesicle trafficking in the regulation of MAK-2 pathway activity and function. Taken together, these data will have significant implications for our mechanistic understanding of MAPK signaling and for homotypic cell-cell communication in fungi and higher eukaryotes.

  19. Comae Berenicids and related activities

    NASA Astrophysics Data System (ADS)

    Koseki, Masahiro

    2011-12-01

    The Comae Berenicids have been considered as a winter shower but lower meteor activities continue the whole year round in this region. It might be called the meteors of Coma Sororum Medusae (CSM) instead of Comae Berenicids (COM). The CSM radiant passes the zenith twice in lower latitudes of the northern hemisphere and CSM activities vary with the altitude of the radiant. December Leonis Minorids (DLM) and September varepsilon-Perseids (SPE) are distinct from the CSM background meteors, but July Pegasids (JPE), delta-Aurigids (DAU) and nu-Aurigids (NAU) are buried in this complex. The conglomeration of DLM, COM and JCO (January Comae Berenicids) has caused confusion in meteor observations as to whether they are three distinct sources or should be considered as one. A simple model of meteor stream structure shows the clear profile of their activities. Although their radiant drifts are overlapping, they might have different parent objects.

  20. 10 CFR 2.709 - Discovery against NRC staff.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Discovery against NRC staff. 2.709 Section 2.709 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS... Sections 147 and 181 of the Atomic Energy Act of 1954, as amended exempt from disclosure under § 2.390,...

  1. 10 CFR 2.709 - Discovery against NRC staff.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Discovery against NRC staff. 2.709 Section 2.709 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS... Sections 147 and 181 of the Atomic Energy Act of 1954, as amended exempt from disclosure under § 2.390,...

  2. 10 CFR 2.709 - Discovery against NRC staff.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Discovery against NRC staff. 2.709 Section 2.709 Energy NUCLEAR REGULATORY COMMISSION AGENCY RULES OF PRACTICE AND PROCEDURE Rules for Formal Adjudications § 2... Energy Act of 1954, as amended exempt from disclosure under § 2.390, the presiding officer may issue...

  3. 10 CFR 2.709 - Discovery against NRC staff.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Discovery against NRC staff. 2.709 Section 2.709 Energy NUCLEAR REGULATORY COMMISSION AGENCY RULES OF PRACTICE AND PROCEDURE Rules for Formal Adjudications § 2... Energy Act of 1954, as amended exempt from disclosure under § 2.390, the presiding officer may issue...

  4. 10 CFR 2.709 - Discovery against NRC staff.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Discovery against NRC staff. 2.709 Section 2.709 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS... Sections 147 and 181 of the Atomic Energy Act of 1954, as amended exempt from disclosure under § 2.390,...

  5. [NRC/GT: Six Year One Research Studies.

    ERIC Educational Resources Information Center

    Gubbins, E. Jean, Ed.

    1992-01-01

    This newsletter focuses on six Year 1 research projects associated with the National Research Center on the Gifted and Talented (NRC/GT). The updates address: "Regular Classroom Practices With Gifted Students: Findings from the Classroom Practices Survey" (Francis X. Archambault, Jr. and others); "The Classroom Practices Study:…

  6. 10 CFR 14.35 - Limitation on NRC's authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Limitation on NRC's authority. 14.35 Section 14.35 Energy NUCLEAR REGULATORY COMMISSION ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT Commission Action and... General or his designee. For the purposes of this paragraph, a principal claim and any derivative or...

  7. 10 CFR 14.35 - Limitation on NRC's authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Limitation on NRC's authority. 14.35 Section 14.35 Energy NUCLEAR REGULATORY COMMISSION ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT Commission Action and... General or his designee. For the purposes of this paragraph, a principal claim and any derivative or...

  8. US NRC-Sponsored Research on Stress Corrosion Cracking Susceptibility of Dry Storage Canister Materials in Marine Environments - 13344

    SciTech Connect

    Oberson, Greg; Dunn, Darrell; Mintz, Todd; He, Xihua; Pabalan, Roberto; Miller, Larry

    2013-07-01

    At a number of locations in the U.S., spent nuclear fuel (SNF) is maintained at independent spent fuel storage installations (ISFSIs). These ISFSIs, which include operating and decommissioned reactor sites, Department of Energy facilities in Idaho, and others, are licensed by the U.S. Nuclear Regulatory Commission (NRC) under Title 10 of the Code of Federal Regulations, Part 72. The SNF is stored in dry cask storage systems, which most commonly consist of a welded austenitic stainless steel canister within a larger concrete vault or overpack vented to the external atmosphere to allow airflow for cooling. Some ISFSIs are located in marine environments where there may be high concentrations of airborne chloride salts. If salts were to deposit on the canisters via the external vents, a chloride-rich brine could form by deliquescence. Austenitic stainless steels are susceptible to chloride-induced stress corrosion cracking (SCC), particularly in the presence of residual tensile stresses from welding or other fabrication processes. SCC could allow helium to leak out of a canister if the wall is breached or otherwise compromise its structural integrity. There is currently limited understanding of the conditions that will affect the SCC susceptibility of austenitic stainless steel exposed to marine salts. NRC previously conducted a scoping study of this phenomenon, reported in NUREG/CR-7030 in 2010. Given apparent conservatisms and limitations in this study, NRC has sponsored a follow-on research program to more systematically investigate various factors that may affect SCC including temperature, humidity, salt concentration, and stress level. The activities within this research program include: (1) measurement of relative humidity (RH) for deliquescence of sea salt, (2) SCC testing within the range of natural absolute humidity, (3) SCC testing at elevated temperatures, (4) SCC testing at high humidity conditions, and (5) SCC testing with various applied stresses. Results

  9. 77 FR 33786 - NRC Enforcement Policy Revision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... its Enforcement Policy (Enforcement Policy or Policy) to address construction-related topics... industry (i.e., reactor and materials licensees, vendors, and contractors) on construction-related topics... Enforcement Policy. These sections also provide background information on those topics evaluated by the...

  10. Enhancement of NRC station blackout requirements for nuclear power plants

    SciTech Connect

    McConnell, M. W.

    2012-07-01

    The U.S. Nuclear Regulatory Commission (NRC) established a Near-Term Task Force (NTTF) in response to Commission direction to conduct a systematic and methodical review of NRC processes and regulations to determine whether the agency should make additional improvements to its regulatory system and to make recommendations to the Commission for its policy direction, in light of the accident at the Fukushima Dai-ichi Nuclear Power Plant. The NTTF's review resulted in a set of recommendations that took a balanced approach to defense-in-depth as applied to low-likelihood, high-consequence events such as prolonged station blackout (SBO) resulting from severe natural phenomena. Part 50, Section 63, of Title 10 of the Code of Federal Regulations (CFR), 'Loss of All Alternating Current Power,' currently requires that each nuclear power plant must be able to cool the reactor core and maintain containment integrity for a specified duration of an SBO. The SBO duration and mitigation strategy for each nuclear power plant is site specific and is based on the robustness of the local transmission system and the transmission system operator's capability to restore offsite power to the nuclear power plant. With regard to SBO, the NTTF recommended that the NRC strengthen SBO mitigation capability at all operating and new reactors for design-basis and beyond-design-basis external events. The NTTF also recommended strengthening emergency preparedness for prolonged SBO and multi-unit events. These recommendations, taken together, are intended to clarify and strengthen US nuclear reactor safety regarding protection against and mitigation of the consequences of natural disasters and emergency preparedness during SBO. The focus of this paper is on the existing SBO requirements and NRC initiatives to strengthen SBO capability at all operating and new reactors to address prolonged SBO stemming from design-basis and beyond-design-basis external events. The NRC initiatives are intended to

  11. 76 FR 48919 - NRC Enforcement Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ..., Announcements, and Directives Branch (RADB), Office of Administration, Mail Stop: TWB-05-B01M, U.S. Nuclear... chemical hazard exposures resulting from licensed or certified activities * * *.'' Add a new section, as... violation must either not be repetitive as a result of inadequate corrective action, or, if repetitive,...

  12. SU-A-210-02: Medical Physics Opportunities at the NRC

    SciTech Connect

    Abogunde, M.

    2015-06-15

    The purpose of this student annual meeting is to address topics that are becoming more relevant to medical physicists, but are not frequently addressed, especially for students and trainees just entering the field. The talk is divided into two parts: medical billing and regulations. Hsinshun Wu – Why should we learn radiation oncology billing? Many medical physicists do not like to be involved with medical billing or coding during their career. They believe billing is not their responsibility and sometimes they even refuse to participate in the billing process if given the chance. This presentation will talk about a physicist’s long career and share his own experience that knowing medical billing is not only important and necessary for every young medical physicist, but that good billing knowledge could provide a valuable contribution to his/her medical physics development. Learning Objectives: The audience will learn the basic definition of Current Procedural Terminology (CPT) codes performed in a Radiation Oncology Department. Understand the differences between hospital coding and physician-based or freestanding coding. Apply proper CPT coding for each Radiation Oncology procedure. Each procedure with its specific CPT code will be discussed in detail. The talk will focus on the process of care and use of actual workflow to understand each CPT code. Example coding of a typical Radiation Oncology procedure. Special procedure coding such as brachytherapy, proton therapy, radiosurgery, and SBRT. Maryann Abogunde – Medical physics opportunities at the Nuclear Regulatory Commission (NRC) The NRC’s responsibilities include the regulation of medical uses of byproduct (radioactive) materials and oversight of medical use end-users (licensees) through a combination of regulatory requirements, licensing, safety oversight including inspection and enforcement, operational experience evaluation, and regulatory support activities. This presentation will explore the

  13. Licensee over-reliance on conservatisms in NRC guidance regarding the release of patients treated with 131I.

    PubMed

    Siegel, Jeffry A; Marcus, Carol S; Stabin, Michael G

    2007-12-01

    Medical licensees are required to comply with U.S. Nuclear Regulatory Commission (NRC) regulations pertaining to the release of patients administered radioactive material. However, use of the associated NRC guidance expressed in NUREG-1556, Volume 9, is completely optional and has been shown to be overly conservative. Rigid adherence to the guidance recommendations has placed an undue burden on nuclear medicine therapy patients and their families, as well as licensees responsible for ensuring compliance with NRC requirements. More realistic guidance has been published by other responsible professional societies and will be presented in this work. These more realistic calculations allow for higher releasable activity levels than the widely adopted NUREG levels, particularly for thyroid cancer patients. The guidance-suggested releasable activity limit is similar to our calculational result for hyperthyroid patients, 2.1 GBq (57 mCi) compared to 2.3 GBq (62 mCi), but is significantly lower for thyroid cancer patients, 6.6 GBq (179 mCi) vs. 16.9 GBq (457 mCi) using the regulatory definition of the total effective dose equivalent (TEDE). Higher limits are both possible and reasonable, if the permissible extra-regulatory definition of the TEDE is used in which the effective dose equivalent (EDE), rather than the deep-dose equivalent (DDE), is determined. We maintain that professionals evaluating compliance with the NRC requirements for patient release, pursuant to 10 CFR 35.75, should use the procedures presented here and not rely automatically on the NUREG.

  14. 76 FR 57767 - Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for... NRC Generic Letter 2011- XX: Seismic Risk Evaluations for Operating Reactors. This action is...

  15. Carboxyl ester hydrolases production and growth of a halophilic archaeon, Halobacterium sp. NRC-1.

    PubMed

    Camacho, Rosa María; Mateos-Díaz, Juan Carlos; Diaz-Montaño, Dulce María; González-Reynoso, Orfil; Córdova, Jesús

    2010-01-01

    The capability of Halobacterium sp. NRC-1 to synthesize carboxyl ester hydrolases was investigated, and the effect of physicochemical conditions on the growth rate and production of esterases was evaluated. The haloarchaeon synthesized a carboxyl ester hydrolase, confirming the genomic prediction. This enzymatic activity was intracellularly produced as a growth-associated metabolite. Esterase activity was assayed using different p-nitrophenyl-esters and triacyl-glycerides, which showed a preference for hydrolyzing tributyrin. The archaeal growth rate and esterase production were significantly influenced by the pH and the NaCl concentration. An interaction effect between temperature and NaCl was also seen. The maximal growth rate and esterase production found for Halobacterium sp. NRC-1 were 0.136 h(-1) (at 4.2 M NaCl, pH 6 and 44 degrees C) and 1.64 U/l (at 4.6 M NaCl, pH 6 and 30 degrees C), respectively. Furthermore, the effects of NaCl concentration, pH and temperature on enzyme activity were studied. Two maximal esterase activities were elucidated from the intracellular crude extract when it was incubated at different NaCl concentrations (1 M and 5 M) and at different pHs (6 and 7.5). This is the first report that shows experimentally the synthesis of carboxyl ester hydrolases by Halobacterium sp. NRC-1. This enzyme was found to be extremely halophilic (5 M NaCl) and thermophilic (80 degrees C), making it very interesting for future investigations in non-aqueous biocatalysis.

  16. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory...

  17. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory...

  18. 10 CFR Appendix A to Part 25 - Fees for NRC Access Authorization

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Fees for NRC Access Authorization A Appendix A to Part 25 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION Pt. 25, App. A Appendix A to Part 25—Fees for NRC Access Authorization The NRC application fee for an access authorization of type * * * Is the...

  19. 10 CFR Appendix A to Part 25 - Fees for NRC Access Authorization

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Fees for NRC Access Authorization A Appendix A to Part 25 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION Pt. 25, App. A Appendix A to Part 25—Fees for NRC Access Authorization The NRC application fee for an access authorization of type * * * Is the...

  20. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory...

  1. 10 CFR 7.15 - Procedures for closing an NRC advisory committee meeting.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Procedures for closing an NRC advisory committee meeting. 7.15 Section 7.15 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.15 Procedures for closing an NRC advisory committee meeting. (a) To close all or part of a meeting of an NRC...

  2. 10 CFR 7.15 - Procedures for closing an NRC advisory committee meeting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Procedures for closing an NRC advisory committee meeting. 7.15 Section 7.15 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.15 Procedures for closing an NRC advisory committee meeting. (a) To close all or part of a meeting of an NRC...

  3. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory...

  4. 10 CFR Appendix A to Part 25 - Fees for NRC Access Authorization

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Fees for NRC Access Authorization A Appendix A to Part 25 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION Pt. 25, App. A Appendix A to Part 25—Fees for NRC Access Authorization The NRC application fee for an access authorization of type . . . Is the...

  5. 10 CFR 7.15 - Procedures for closing an NRC advisory committee meeting.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Procedures for closing an NRC advisory committee meeting. 7.15 Section 7.15 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.15 Procedures for closing an NRC advisory committee meeting. (a) To close all or part of a meeting of an NRC...

  6. 10 CFR Appendix A to Part 25 - Fees for NRC Access Authorization

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Fees for NRC Access Authorization A Appendix A to Part 25 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION Pt. 25, App. A Appendix A to Part 25—Fees for NRC Access Authorization The NRC application fee for an access authorization of type * * * Is the...

  7. 10 CFR 7.15 - Procedures for closing an NRC advisory committee meeting.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Procedures for closing an NRC advisory committee meeting. 7.15 Section 7.15 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.15 Procedures for closing an NRC advisory committee meeting. (a) To close all or part of a meeting of an NRC...

  8. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory...

  9. 10 CFR 7.15 - Procedures for closing an NRC advisory committee meeting.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Procedures for closing an NRC advisory committee meeting. 7.15 Section 7.15 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.15 Procedures for closing an NRC advisory committee meeting. (a) To close all or part of a meeting of an NRC...

  10. 10 CFR Appendix A to Part 25 - Fees for NRC Access Authorization

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Fees for NRC Access Authorization A Appendix A to Part 25 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION Pt. 25, App. A Appendix A to Part 25—Fees for NRC Access Authorization The NRC application fee for an access authorization of type . . . Is the...

  11. 10 CFR 2.1202 - Authority and role of NRC staff.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Authority and role of NRC staff. 2.1202 Section 2.1202 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Informal Hearing Procedures for NRC Adjudications § 2.1202 Authority and role of NRC staff. (a...

  12. 10 CFR 1.53 - Use of NRC seal or replicas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Use of NRC seal or replicas. 1.53 Section 1.53 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION NRC Seal and Flag § 1.53 Use of NRC seal or replicas. (a) The use of the seal or replicas is restricted to the following:...

  13. 10 CFR 1.53 - Use of NRC seal or replicas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Use of NRC seal or replicas. 1.53 Section 1.53 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION NRC Seal and Flag § 1.53 Use of NRC seal or replicas. (a) The use of the seal or replicas is restricted to the following:...

  14. 10 CFR 1.53 - Use of NRC seal or replicas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Use of NRC seal or replicas. 1.53 Section 1.53 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION NRC Seal and Flag § 1.53 Use of NRC seal or replicas. (a) The use of the seal or replicas is restricted to the following:...

  15. 10 CFR 1.53 - Use of NRC seal or replicas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Use of NRC seal or replicas. 1.53 Section 1.53 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION NRC Seal and Flag § 1.53 Use of NRC seal or replicas. (a) The use of the seal or replicas is restricted to the following:...

  16. 10 CFR 1.53 - Use of NRC seal or replicas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Use of NRC seal or replicas. 1.53 Section 1.53 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION NRC Seal and Flag § 1.53 Use of NRC seal or replicas. (a) The use of the seal or replicas is restricted to the following:...

  17. EPRI/NRC-RES fire PRA guide for nuclear power facilities. Volume 1, summary and overview.

    SciTech Connect

    Not Available

    2004-09-01

    This report documents state-of-the-art methods, tools, and data for the conduct of a fire Probabilistic Risk Assessment (PRA) for a commercial nuclear power plant (NPP) application. The methods have been developed under the Fire Risk Re-quantification Study. This study was conducted as a joint activity between EPRI and the U. S. NRC Office of Nuclear Regulatory Research (RES) under the terms of an EPRI/RES Memorandum of Understanding [RS.1] and an accompanying Fire Research Addendum [RS.2]. Industry participants supported demonstration analyses and provided peer review of this methodology. The documented methods are intended to support future applications of Fire PRA, including risk-informed regulatory applications. The documented method reflects state-of-the-art fire risk analysis approaches. The primary objective of the Fire Risk Study was to consolidate recent research and development activities into a single state-of-the-art fire PRA analysis methodology. Methodological issues raised in past fire risk analyses, including the Individual Plant Examination of External Events (IPEEE) fire analyses, have been addressed to the extent allowed by the current state-of-the-art and the overall project scope. Methodological debates were resolved through a consensus process between experts representing both EPRI and RES. The consensus process included a provision whereby each major party (EPRI and RES) could maintain differing technical positions if consensus could not be reached. No cases were encountered where this provision was invoked. While the primary objective of the project was to consolidate existing state-of-the-art methods, in many areas, the newly documented methods represent a significant advancement over previously documented methods. In several areas, this project has, in fact, developed new methods and approaches. Such advances typically relate to areas of past methodological debate.

  18. NRC drug-free workplace plan. Revision 1

    SciTech Connect

    1997-11-01

    On September 15, 1986, President Reagan signed Executive Order 12564, establishing the goal of a Drug-Free Federal Workplace. The Order made it a condition of employment that all Federal employees refrain from using illegal drugs on or off duty. On July 11, 1987, Congress passed legislation affecting implementation of the Executive Order under Section 503 of the Supplemental Appropriations Act of 1987, Public Law 100-71 (the Act). The Nuclear Regulatory Commission first issued the NRC Drug Testing Plan to set forth objectives, policies, procedures, and implementation guidelines to achieve a drug-free Federal workplace, consistent with the Executive Order and Section 503 of the Act. Revision 1, titled, ``NRC Drug-Free Workplace Plan,`` supersedes the previous version and its supplements and incorporates changes to reflect current guidance from the Department of Justice, the Department of Health and Human Services, as well as other guidance.

  19. Recommendations for NEAMS Engagement with the NRC: Preliminary Report

    SciTech Connect

    Bernholdt, David E

    2012-06-01

    The vision of the Nuclear Energy Advanced Modeling and Simulation (NEAMS) program is to bring a new generation of analytic tools to the nuclear engineering community in order to facilitate students, faculty, industry and laboratory researchers in investigating advanced reactor and fuel cycle designs. Although primarily targeting at advance nuclear technologies, it is anticipated that these new capabilities will also become interesting and useful to the nuclear regulator Consequently, the NEAMS program needs to engage with the Nuclear Regulatory Commission as the software is being developed to ensure that they are familiar with and ready to respond to this novel approach when the need arises. Through discussions between key NEAMS and NRC staff members, we tentatively recommend annual briefings to the Division of Systems Analysis in the NRC's Office of Nuclear Regulatory Research. However the NEAC subcommittee review of the NEAMS program may yield recommendations that would need to be considered before finalizing this plan.

  20. EPRI/NRC-RES fire human reliability analysis guidelines.

    SciTech Connect

    Lewis, Stuart R.; Cooper, Susan E.; Najafi, Bijan; Collins, Erin; Hannaman, Bill; Kohlhepp, Kaydee; Grobbelaar, Jan; Hill, Kendra; Hendrickson, Stacey M. Langfitt; Forester, John Alan; Julius, Jeff

    2010-03-01

    During the 1990s, the Electric Power Research Institute (EPRI) developed methods for fire risk analysis to support its utility members in the preparation of responses to Generic Letter 88-20, Supplement 4, 'Individual Plant Examination - External Events' (IPEEE). This effort produced a Fire Risk Assessment methodology for operations at power that was used by the majority of U.S. nuclear power plants (NPPs) in support of the IPEEE program and several NPPs overseas. Although these methods were acceptable for accomplishing the objectives of the IPEEE, EPRI and the U.S. Nuclear Regulatory Commission (NRC) recognized that they required upgrades to support current requirements for risk-informed, performance-based (RI/PB) applications. In 2001, EPRI and the USNRC's Office of Nuclear Regulatory Research (RES) embarked on a cooperative project to improve the state-of-the-art in fire risk assessment to support a new risk-informed environment in fire protection. This project produced a consensus document, NUREG/CR-6850 (EPRI 1011989), entitled 'Fire PRA Methodology for Nuclear Power Facilities' which addressed fire risk for at power operations. NUREG/CR-6850 developed high level guidance on the process for identification and inclusion of human failure events (HFEs) into the fire PRA (FPRA), and a methodology for assigning quantitative screening values to these HFEs. It outlined the initial considerations of performance shaping factors (PSFs) and related fire effects that may need to be addressed in developing best-estimate human error probabilities (HEPs). However, NUREG/CR-6850 did not describe a methodology to develop best-estimate HEPs given the PSFs and the fire-related effects. In 2007, EPRI and RES embarked on another cooperative project to develop explicit guidance for estimating HEPs for human failure events under fire generated conditions, building upon existing human reliability analysis (HRA) methods. This document provides a methodology and guidance for conducting

  1. NRC Enforcement Policy Review, July 1995-July 1997

    SciTech Connect

    Lieberman, J.; Pedersen, R.M.

    1998-04-01

    On June 30, 1995, the Nuclear Regulatory Commission (NRC) issued a complete revision of its General Statement of Policy and Procedure for Enforcement Action (Enforcement Policy) (60 FR 34381). In approving the 1995 revision to the Enforcement Policy, the Commission directed the staff to perform a review of its implementation of the Policy after approximately 2 years of experience and to consider public comments. This report represents the results of that review.

  2. Investigations of photoreceptor synaptic transmission and light adaptation in the zebrafish visual mutant nrc.

    PubMed

    Van Epps, H A; Yim, C M; Hurley, J B; Brockerhoff, S E

    2001-03-01

    To characterize the retinal physiology of the zebrafish visual mutant no optokinetic response c (nrc) and to identify the genetic map position of the nrc mutation. Electroretinograms were recorded from wild-type and nrc zebrafish larvae between 5 to 6 days postfertilization. Responses to flash stimuli, On and Off responses to prolonged light stimuli, and responses to flash stimuli with constant background illumination were characterized. The glutamate agonist, 2-amino-4-phosphonobutyric acid (APB) was used to examine the photoreceptor specific a-wave component of the electroretinogram. Amplified fragment length polymorphism methodology was used to place the nrc mutation on the zebrafish genomic map. nrc and wild-type zebrafish larvae 5 to 6 days postfertilization have similar threshold responses to light, but the b-wave of the nrc electroretinogram is significantly delayed and reduced in amplitude. On and Off responses of nrc larvae to prolonged light have multiple oscillations that do not occur in normal zebrafish larvae after 5 days postfertilization. Analysis of the b-wave demonstrated a light adaptation defect in nrc that causes saturation at background light levels approximately 1 order of magnitude less than those with wild-type larvae. Application of the glutamate analog, APB, uncovered the photoreceptor component of the electroretinogram and revealed a light adaptation defect in nrc photoreceptors. The nrc mutation was placed approximately 0.2 cM from sequence length polymorphism marker Z7504 on linkage group 10. The zebrafish mutant nrc is a possible model for human retinal disease. nrc has defects in photoreceptor synaptic transmission and light adaptation. The nrc mutant phenotype shows striking similarities with phenotypes of dystrophin glycoprotein complex mutants, including patients with Duchenne/Becker muscular dystrophy. Localization of the nrc mutation now makes it possible to evaluate candidate genes and clone the nrc gene.

  3. Activities in Science Related to Space.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC. Educational Programs Div.

    Contained are a collection of science activities based upon forty-six scientific concepts related to space science. These activities are designed for junior high school science, but a much wider grade level range of use is possible. The booklet is primarily intended for teacher use. Each series of concept-oriented activities is independent of the…

  4. Memorandum of Understanding Between U.S. EPA Superfund and U.S. NRC

    SciTech Connect

    Walker, Stuart

    2008-01-15

    The Environmental Protection Agency (EPA) Office of Superfund Remediation and Technology Innovation (OSRTI) and the Nuclear Regulatory Commission (NRC) are responsible for implementing the 'Memorandum of Understanding Between the Environmental Protection Agency and the Nuclear Regulatory Commission: Consultation and Finality on Decommissioning and Decontamination of Contaminated Sites'. This paper provides a brief overview of the origin of the Memorandum of Understanding (MOU), the major features of the MOU, and how the MOU has been implemented site specifically. EPA and NRC developed the MOU in response to direction from the House Committee on Appropriations to EPA and NRC to work together to address the potential for dual regulation. The MOU was signed by EPA on September 30, 2002 and NRC on October 9, 2002. The two agencies had worked on the MOU since March 2000. While both EPA and NRC have statutory authority to clean up these sites, the MOU provides consultation procedures between EPA and NRC to eliminate dual regulation. Under the MOU, EPA and NRC identified the interactions of the two agencies for the decommissioning and decontamination of NRC-licensed sites and the ways in which those responsibilities will be exercised. Except for Section VI, which addresses corrective action under the Resource Conservation and Recovery Act (RCRA), this MOU is limited to the coordination between EPA, when acting under its CERCLA authority, and NRC, when a facility licensed by the NRC is undergoing decommissioning, or when a facility has completed decommissioning, and the NRC has terminated its license. EPA believes that implementation of the MOU between the two agencies will ensure that future confusion about dual regulation does not occur regarding the cleanup and reuse of NRC-licensed sites. NRC and EPA have so far exchanged MOU consultation letters on eight NRC-licensed sites. EPA has responded to each consultation request with a letter expressing its views on actions

  5. Factors Associated with Evaluating Public Relations Activities.

    ERIC Educational Resources Information Center

    McElreath, Mark P.

    More than 150 public relations practitioners responded to a survey designed to identify and clarify factors associated with evaluative research in public relations. Responses indicated that (1) no more than half the practitioners formally evaluate their public relations activities on a regular basis; (2) the majority of evaluation is done…

  6. Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1.

    PubMed

    Berquist, Brian R; DasSarma, Priya; DasSarma, Shiladitya

    2007-06-08

    Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those found in eukaryotes. Functional assignments of archaeal DNA replication genes have been primarily based upon sequence homology and biochemical studies of replisome components, but few genetic studies have been conducted thus far. We have developed a tractable genetic system for knockout analysis of genes in the model halophilic archaeon, Halobacterium sp. NRC-1, and used it to determine which DNA replication genes are essential. Using a directed in-frame gene knockout method in Halobacterium sp. NRC-1, we examined nineteen genes predicted to be involved in DNA replication. Preliminary bioinformatic analysis of the large haloarchaeal Orc/Cdc6 family, related to eukaryotic Orc1 and Cdc6, showed five distinct clades of Orc/Cdc6 proteins conserved in all sequenced haloarchaea. Of ten orc/cdc6 genes in Halobacterium sp. NRC-1, only two were found to be essential, orc10, on the large chromosome, and orc2, on the minichromosome, pNRC200. Of the three replicative-type DNA polymerase genes, two were essential: the chromosomally encoded B family, polB1, and the chromosomally encoded euryarchaeal-specific D family, polD1/D2 (formerly called polA1/polA2 in the Halobacterium sp. NRC-1 genome sequence). The pNRC200-encoded B family polymerase, polB2, was non-essential. Accessory genes for DNA replication initiation and elongation factors, including the putative replicative helicase, mcm, the eukaryotic-type DNA primase, pri1/pri2, the DNA polymerase sliding clamp, pcn, and the flap endonuclease, rad2, were all essential. Targeted genes were classified as non-essential if knockouts were obtained and essential based on statistical analysis and/or by demonstrating the inability to isolate chromosomal knockouts except in the presence of a complementing plasmid copy of the gene. The results showed that ten out of nineteen eukaryotic-type DNA replication genes are

  7. Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1

    PubMed Central

    Berquist, Brian R; DasSarma, Priya; DasSarma, Shiladitya

    2007-01-01

    Background Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those found in eukaryotes. Functional assignments of archaeal DNA replication genes have been primarily based upon sequence homology and biochemical studies of replisome components, but few genetic studies have been conducted thus far. We have developed a tractable genetic system for knockout analysis of genes in the model halophilic archaeon, Halobacterium sp. NRC-1, and used it to determine which DNA replication genes are essential. Results Using a directed in-frame gene knockout method in Halobacterium sp. NRC-1, we examined nineteen genes predicted to be involved in DNA replication. Preliminary bioinformatic analysis of the large haloarchaeal Orc/Cdc6 family, related to eukaryotic Orc1 and Cdc6, showed five distinct clades of Orc/Cdc6 proteins conserved in all sequenced haloarchaea. Of ten orc/cdc6 genes in Halobacterium sp. NRC-1, only two were found to be essential, orc10, on the large chromosome, and orc2, on the minichromosome, pNRC200. Of the three replicative-type DNA polymerase genes, two were essential: the chromosomally encoded B family, polB1, and the chromosomally encoded euryarchaeal-specific D family, polD1/D2 (formerly called polA1/polA2 in the Halobacterium sp. NRC-1 genome sequence). The pNRC200-encoded B family polymerase, polB2, was non-essential. Accessory genes for DNA replication initiation and elongation factors, including the putative replicative helicase, mcm, the eukaryotic-type DNA primase, pri1/pri2, the DNA polymerase sliding clamp, pcn, and the flap endonuclease, rad2, were all essential. Targeted genes were classified as non-essential if knockouts were obtained and essential based on statistical analysis and/or by demonstrating the inability to isolate chromosomal knockouts except in the presence of a complementing plasmid copy of the gene. Conclusion The results showed that ten out of nineteen eukaryotic

  8. Accident Conditions versus Regulatory Test for NRC-Approved UF6 Packages

    SciTech Connect

    MILLS, G. SCOTT; AMMERMAN, DOUGLAS J.; LOPEZ, CARLOS

    2003-01-01

    The Nuclear Regulatory Commission (NRC) approves new package designs for shipping fissile quantities of UF{sub 6}. Currently there are three packages approved by the NRC for domestic shipments of fissile quantities of UF{sub 6}: NCI-21PF-1; UX-30; and ESP30X. For approval by the NRC, packages must be subjected to a sequence of physical tests to simulate transportation accident conditions as described in 10 CFR Part 71. The primary objective of this project was to relate the conditions experienced by these packages in the tests described in 10 CFR Part 71 to conditions potentially encountered in actual accidents and to estimate the probabilities of such accidents. Comparison of the effects of actual accident conditions to 10 CFR Part 71 tests was achieved by means of computer modeling of structural effects on the packages due to impacts with actual surfaces, and thermal effects resulting from test and other fire scenarios. In addition, the likelihood of encountering bodies of water or sufficient rainfall to cause complete or partial immersion during transport over representative truck routes was assessed. Modeled effects, and their associated probabilities, were combined with existing event-tree data, plus accident rates and other characteristics gathered from representative routes, to derive generalized probabilities of encountering accident conditions comparable to the 10 CFR Part 71 conditions. This analysis suggests that the regulatory conditions are unlikely to be exceeded in real accidents, i.e. the likelihood of UF{sub 6} being dispersed as a result of accident impact or fire is small. Moreover, given that an accident has occurred, exposure to water by fire-fighting, heavy rain or submersion in a body of water is even less probable by factors ranging from 0.5 to 8E-6.

  9. Gender Related Differences in Science Activities.

    ERIC Educational Resources Information Center

    Tobin, Kenneth; Garnett, Pamela

    1987-01-01

    Discusses a study which examined gender related differences in participation in science activities. Based on interpretive observations and formal interviews, gender related differences in engagement patterns were evident with the high school students. Presents six assertions and provides supporting examples of gender differences. (ML)

  10. Structuring medication related activities for information management.

    PubMed

    Luukkonen, Irmeli; Mykkänen, Juha; Kivekäs, Eija; Saranto, Kaija

    2014-01-01

    Medication treatment and the related information management are central parts of a patient's health care. As a cross-organizational and cooperative process, medication information management is a complex domain for development activities. We studied medication activities and related information management in a regional project in order to produce a shared broad picture of its processes and to understand the main issues and the needs for improvement. In this paper we provide a summary of the findings in a structured form, based on a six-dimensioned framework for design and analysis of activities and processes.

  11. Managing aging in nuclear power plants: Insights from NRC maintenance team inspection reports

    SciTech Connect

    Fresco, A.; Subudhi, M.; Gunther, W.; Grove, E.; Taylor, J.

    1993-12-01

    A plant`s maintenance program is the principal vehicle through which age-related degradation is managed. From 1988 to 1991, the NRC evaluated the maintenance program of every nuclear power plant in the United States. Forty-four out of a total of 67 of the reports issued on these in-depth team inspections were reviewed for insights into the strengths and weaknesses of the programs as related to the need to understand and manage the effects of aging on nuclear plant systems, structures, and components. Relevant information was extracted from these inspection reports and sorted into several categories, including Specific Aging Insights, Preventive Maintenance, Predictive Maintenance and Condition Monitoring, Post Maintenance Testing, Failure Trending, Root Cause Analysis and Usage of Probabilistic Risk Assessment in the Maintenance Process. Specific examples of inspection and monitoring techniques successfully used by utilities to detect degradation due to aging have been identified. The information also was sorted according to systems and components, including: Auxiliary Feedwater, Main Feedwater, High Pressure Injection for both BWRs and PWRs, Service Water, Instrument Air, and Emergency Diesel Generator Air Start Systems, and Emergency Diesel Generators Air Start Systems, emergency diesel generators, electrical components such as switchgear, breakers, relays, and motor control centers, motor operated valves and check valves. This information was compared to insights gained from the Nuclear Plant Aging Research (NPAR) Program. Attributes of plant maintenance programs where the NRC inspectors felt that improvement was needed to properly address the aging issue also are discussed.

  12. Peer Review of NRC Standardized Plant Analysis Risk Models

    SciTech Connect

    Anthony Koonce; James Knudsen; Robert Buell

    2011-03-01

    The Nuclear Regulatory Commission (NRC) Standardized Plant Analysis Risk (SPAR) Models underwent a Peer Review using ASME PRA standard (Addendum C) as endorsed by NRC in Regulatory Guide (RG) 1.200. The review was performed by a mix of industry probabilistic risk analysis (PRA) experts and NRC PRA experts. Representative SPAR models, one PWR and one BWR, were reviewed against Capability Category I of the ASME PRA standard. Capability Category I was selected as the basis for review due to the specific uses/applications of the SPAR models. The BWR SPAR model was reviewed against 331 ASME PRA Standard Supporting Requirements; however, based on the Capability Category I level of review and the absence of internal flooding and containment performance (LERF) logic only 216 requirements were determined to be applicable. Based on the review, the BWR SPAR model met 139 of the 216 supporting requirements. The review also generated 200 findings or suggestions. Of these 200 findings and suggestions 142 were findings and 58 were suggestions. The PWR SPAR model was also evaluated against the same 331 ASME PRA Standard Supporting Requirements. Of these requirements only 215 were deemed appropriate for the review (for the same reason as noted for the BWR). The PWR review determined that 125 of the 215 supporting requirements met Capability Category I or greater. The review identified 101 findings or suggestions (76 findings and 25 suggestions). These findings or suggestions were developed to identify areas where SPAR models could be enhanced. A process to prioritize and incorporate the findings/suggestions supporting requirements into the SPAR models is being developed. The prioritization process focuses on those findings that will enhance the accuracy, completeness and usability of the SPAR models.

  13. The cobY gene of the archaeon Halobacterium sp. strain NRC-1 is required for de novo cobamide synthesis.

    PubMed

    Woodson, J D; Peck, R F; Krebs, M P; Escalante-Semerena, J C

    2003-01-01

    Genetic and nutritional analyses of mutants of the extremely halophilic archaeon Halobacterium sp. strain NRC-1 showed that open reading frame (ORF) Vng1581C encodes a protein with nucleoside triphosphate:adenosylcobinamide-phosphate nucleotidyltransferase enzyme activity. This activity was previously associated with the cobY gene of the methanogenic archaeon Methanobacterium thermoautotrophicum strain DeltaH, but no evidence was obtained to demonstrate the direct involvement of this protein in cobamide biosynthesis in archaea. Computer analysis of the Halobacterium sp. strain NRC-1 ORF Vng1581C gene and the cobY gene of M. thermoautotrophicum strain DeltaH showed the primary amino acid sequence of the proteins encoded by these two genes to be 35% identical and 48% similar. A strain of Halobacterium sp. strain NRC-1 carrying a null allele of the cobY gene was auxotrophic for cobinamide-GDP, a known intermediate of the late steps of cobamide biosynthesis. The auxotrophic requirement for cobinamide-GDP was corrected when a wild-type allele of cobY was introduced into the mutant strain, demonstrating that the lack of cobY function was solely responsible for the observed block in cobamide biosynthesis in this archaeon. The data also show that Halobacterium sp. strain NRC-1 possesses a high-affinity transport system for corrinoids and that this archaeon can synthesize cobamides de novo under aerobic growth conditions. To the best of our knowledge this is the first genetic and nutritional analysis of cobalamin biosynthetic mutants in archaea.

  14. The cobY Gene of the Archaeon Halobacterium sp. Strain NRC-1 Is Required for De Novo Cobamide Synthesis

    PubMed Central

    Woodson, J. D.; Peck, R. F.; Krebs, M. P.; Escalante-Semerena, J. C.

    2003-01-01

    Genetic and nutritional analyses of mutants of the extremely halophilic archaeon Halobacterium sp. strain NRC-1 showed that open reading frame (ORF) Vng1581C encodes a protein with nucleoside triphosphate:adenosylcobinamide-phosphate nucleotidyltransferase enzyme activity. This activity was previously associated with the cobY gene of the methanogenic archaeon Methanobacterium thermoautotrophicum strain ΔH, but no evidence was obtained to demonstrate the direct involvement of this protein in cobamide biosynthesis in archaea. Computer analysis of the Halobacterium sp. strain NRC-1 ORF Vng1581C gene and the cobY gene of M. thermoautotrophicum strain ΔH showed the primary amino acid sequence of the proteins encoded by these two genes to be 35% identical and 48% similar. A strain of Halobacterium sp. strain NRC-1 carrying a null allele of the cobY gene was auxotrophic for cobinamide-GDP, a known intermediate of the late steps of cobamide biosynthesis. The auxotrophic requirement for cobinamide-GDP was corrected when a wild-type allele of cobY was introduced into the mutant strain, demonstrating that the lack of cobY function was solely responsible for the observed block in cobamide biosynthesis in this archaeon. The data also show that Halobacterium sp. strain NRC-1 possesses a high-affinity transport system for corrinoids and that this archaeon can synthesize cobamides de novo under aerobic growth conditions. To the best of our knowledge this is the first genetic and nutritional analysis of cobalamin biosynthetic mutants in archaea. PMID:12486068

  15. Tools of Oceanography. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Sands, Florence

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  16. The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair.

    PubMed

    Mahajan, Muktar A; Das, Sharmistha; Zhu, Hong; Tomic-Canic, Marjana; Samuels, Herbert H

    2004-06-01

    Nuclear hormone receptor coregulator (NRC) is a 2,063-amino-acid coregulator of nuclear hormone receptors and other transcription factors (e.g., c-Fos, c-Jun, and NF-kappaB). We and others have generated C57BL/6-129S6 hybrid (C57/129) NRC(+/-) mice that appear outwardly normal and grow and reproduce. In contrast, homozygous deletion of the NRC gene is embryonic lethal. NRC(-/-) embryos are always smaller than NRC(+/+) embryos, and NRC(-/-) embryos die between 8.5 and 12.5 days postcoitus (dpc), suggesting that NRC has a pleotrophic effect on growth. To study this, we derived mouse embryonic fibroblasts (MEFs) from 12.5-dpc embryos, which revealed that NRC(-/-) MEFs exhibit a high rate of apoptosis. Furthermore, a small interfering RNA that targets mouse NRC leads to enhanced apoptosis of wild-type MEFs. The finding that C57/129 NRC(+/-) mice exhibit no apparent phenotype prompted us to develop 129S6 NRC(+/-) mice, since the phenotype(s) of certain gene deletions may be strain dependent. In contrast with C57/129 NRC(+/-) females, 20% of 129S6 NRC(+/-) females are infertile while 80% are hypofertile. The 129S6 NRC(+/-) males produce offspring when crossed with wild-type 129S6 females, although fertility is reduced. The 129S6 NRC(+/-) mice tend to be stunted in their growth compared with their wild-type littermates and exhibit increased postnatal mortality. Lastly, both C57/129 NRC(+/-) and 129S6 NRC(+/-) mice exhibit a spontaneous wound healing defect, indicating that NRC plays an important role in that process. Our findings reveal that NRC is a coregulator that controls many cellular and physiologic processes ranging from growth and development to reproduction and wound repair.

  17. Managing aging in nuclear power plants: Insights from NRC's Maintenance Team Inspection reports

    SciTech Connect

    Fresco, A.; Subudhi, M.

    1992-01-01

    A plant's maintenance program is the principal vehicle through which age-related degradation is managed. From 1988 to 1991, the NRC evaluated the maintenance program of every nuclear power plant in the United States. Forty-four out of a total of sixty-seven of the reports issued on these in-depth team inspections have been reviewed for insights into the strengths and weaknesses of the programs as related to the need to understand and manage the effects of aging on nuclear plant structures, systems, and components (SSCs). Relevant information has been extracted from these inspection reports sorted into several categories; including Specific Aging Insights, Preventive Maintenance, Predictive Maintenance and Condition Monitoring, Post Maintenance Testing, Failure Trending, Root Cause Analysis and Usage of Probabilistic Risk Assessment in the Maintenance Process. Specific examples of inspection and monitoring techniques successfully used by utilities to detect degradation due to aging have been identified.

  18. Managing aging in nuclear power plants: Insights from NRC`s Maintenance Team Inspection reports

    SciTech Connect

    Fresco, A.; Subudhi, M.

    1992-12-31

    A plant`s maintenance program is the principal vehicle through which age-related degradation is managed. From 1988 to 1991, the NRC evaluated the maintenance program of every nuclear power plant in the United States. Forty-four out of a total of sixty-seven of the reports issued on these in-depth team inspections have been reviewed for insights into the strengths and weaknesses of the programs as related to the need to understand and manage the effects of aging on nuclear plant structures, systems, and components (SSCs). Relevant information has been extracted from these inspection reports sorted into several categories; including Specific Aging Insights, Preventive Maintenance, Predictive Maintenance and Condition Monitoring, Post Maintenance Testing, Failure Trending, Root Cause Analysis and Usage of Probabilistic Risk Assessment in the Maintenance Process. Specific examples of inspection and monitoring techniques successfully used by utilities to detect degradation due to aging have been identified.

  19. Antischistosomal activities of mefloquine-related arylmethanols.

    PubMed

    Ingram, Katrin; Ellis, William; Keiser, Jennifer

    2012-06-01

    Interesting antischistosomal properties have been documented for the antimalarial mefloquine, a 4-quinolinemethanol. We evaluated the antischistosomal activities of nine mefloquine-related compounds belonging to the 4-pyridinemethanols, 9-phenanthrenmethanols, and 4-quinolinemethanols. Eight compounds revealed high activities against Schistosoma mansoni in vitro, with two drugs (the 4-quinolinemethanols WR7573 and WR7930) characterized by significantly lower half-maximal inhibitory concentrations (IC(50)s) (2.7 and 3.5 μM, respectively) compared to mefloquine (11.4 μM). Mefloquine and WR7930 showed significantly decreased IC(50)s when incubated in the presence of hemoglobin. High worm burden reductions (WBR) were obtained with enpiroline (WBR, 82.7%; dosage, 200 mg/kg of body weight) and its threo isomers (+)-threo (WBR, 100%) and (-)-threo (WBR, 89%) and with WR7930 (WBR, 87%; dosage, 100 mg/kg) against adult S. mansoni in mice. Furthermore, excellent in vitro and in vivo antischistosomal activity was observed for two WR7930-related structures (WR29252 and WR7524). In addition, mefloquine (WBR, 81%), enpiroline (WBR, 77%), and WR7930 (WBR, 100%) showed high activities against S. haematobium harbored in mice following single oral doses of 200 mg/kg. These results provide a deeper insight into the structural features of the arylmethanols that rule antischistosomal activity. Further studies should be launched with enpiroline and WR7930.

  20. Antischistosomal Activities of Mefloquine-Related Arylmethanols

    PubMed Central

    Ingram, Katrin; Ellis, William

    2012-01-01

    Interesting antischistosomal properties have been documented for the antimalarial mefloquine, a 4-quinolinemethanol. We evaluated the antischistosomal activities of nine mefloquine-related compounds belonging to the 4-pyridinemethanols, 9-phenanthrenmethanols, and 4-quinolinemethanols. Eight compounds revealed high activities against Schistosoma mansoni in vitro, with two drugs (the 4-quinolinemethanols WR7573 and WR7930) characterized by significantly lower half-maximal inhibitory concentrations (IC50s) (2.7 and 3.5 μM, respectively) compared to mefloquine (11.4 μM). Mefloquine and WR7930 showed significantly decreased IC50s when incubated in the presence of hemoglobin. High worm burden reductions (WBR) were obtained with enpiroline (WBR, 82.7%; dosage, 200 mg/kg of body weight) and its threo isomers (+)-threo (WBR, 100%) and (−)-threo (WBR, 89%) and with WR7930 (WBR, 87%; dosage, 100 mg/kg) against adult S. mansoni in mice. Furthermore, excellent in vitro and in vivo antischistosomal activity was observed for two WR7930-related structures (WR29252 and WR7524). In addition, mefloquine (WBR, 81%), enpiroline (WBR, 77%), and WR7930 (WBR, 100%) showed high activities against S. haematobium harbored in mice following single oral doses of 200 mg/kg. These results provide a deeper insight into the structural features of the arylmethanols that rule antischistosomal activity. Further studies should be launched with enpiroline and WR7930. PMID:22470113

  1. The Survival and Resistance of Halobacterium salinarum NRC-1, Halococcus hamelinensis, and Halococcus morrhuae to Simulated Outer Space Solar Radiation.

    PubMed

    Leuko, S; Domingos, C; Parpart, A; Reitz, G; Rettberg, P

    2015-11-01

    Solar radiation is among the most prominent stress factors organisms face during space travel and possibly on other planets. Our analysis of three different halophilic archaea, namely Halobacterium salinarum NRC-1, Halococcus morrhuae, and Halococcus hamelinensis, which were exposed to simulated solar radiation in either dried or liquid state, showed tremendous differences in tolerance and survivability. We found that Hcc. hamelinensis is not able to withstand high fluences of simulated solar radiation compared to the other tested organisms. These results can be correlated to significant differences in genomic integrity following exposure, as visualized by random amplified polymorphic DNA (RAPD)-PCR. In contrast to the other two tested strains, Hcc. hamelinensis accumulates compatible solutes such as trehalose for osmoprotection. The addition of 100 mM trehalose to the growth medium of Hcc. hamelinensis improved its survivability following exposure. Exposure of cells in liquid at different temperatures suggests that Hbt. salinarum NRC-1 is actively repairing cellular and DNA damage during exposure, whereas Hcc. morrhuae exhibits no difference in survival. For Hcc. morrhuae, the high resistance against simulated solar radiation may be explained with the formation of cell clusters. Our experiments showed that these clusters shield cells on the inside against simulated solar radiation, which results in better survival rates at higher fluences when compared to Hbt. salinarum NRC-1 and Hcc. hamelinensis. Overall, this study shows that some halophilic archaea are highly resistant to simulated solar radiation and that they are of high astrobiological significance. Halophiles-Solar radiation-Stress resistance-Survival.

  2. What's new with the NRC certified reference material program.

    PubMed

    Willie, S N

    2001-06-01

    The environmental CRMs currently available from NRC Ottawa comprise four natural waters for trace elements, four biological tissues for trace elements and methylmercury, three marine sediments for major and trace elements (one sediment has certified values for butyltins) and one fish tissue for organochlorines (PCBs, dioxins). Although significant effort has been expended to maintain this suite of materials, several new initiatives have also recently been completed or are in progress. The certified value for arsenobetaine in Dogfish Muscle CRM DORM-2 has been established. The certification approaches, as well as the studies to determine extraction efficiency of this organoarsenic compound, are presented. A stability study has been completed for Hg in a natural water sample and plans are underway for production of a CRM. Assessment of micronutrient stability in seawater for the purposes of CRM production is continuing and progress on this initiative is discussed.

  3. Automatic Activation of Attachment-Related Goals

    PubMed Central

    Gillath, Omri; Mikulincer, Mario; Fitzsimons, Grainne M.; Shaver, Phillip R.; Schachner, Dory A.; Bargh, John A.

    2009-01-01

    When people encounter threats, their attachment systems are activated and they become motivated to seek protection and support through proximity to their attachment figures. Theoretically, therefore, mental representations of attachment figures should be associated with goals related to attaining proximity and safety. The present studies explore this idea by examining the effects of a person’s chronic attachment style and exposure to a particular attachment figure’s name on the automatic activation of attachment-related goals. Studies 1 and 2 examine effects of exposure to the name of a security-providing attachment figure on willingness to self-disclose and seek support (two behaviors related to gaining proximity). Study 3 examines how exposure to names of different relationship partners (with whom a participant has felt secure, anxious, or avoidant) affects the mental accessibility of attachment-related goal words. Taken together, the studies support the idea that mental representations of attachment figures are associated with attachment-related goals. PMID:16963608

  4. Poorly conserved ORFs in the genome of the archaea Halobacterium sp. NRC-1 correspond to expressed proteins.

    PubMed

    Shmuely, H; Dinitz, E; Dahan, I; Eichler, J; Fischer, D; Shaanan, B

    2004-05-22

    A large fraction of open reading frames (ORFs) identified as 'hypothetical' proteins correspond to either 'conserved hypothetical' proteins, representing sequences homologous to ORFs of unknown function from other organisms, or to hypothetical proteins lacking any significant sequence similarity to other ORFs in the databases. Elucidating the functions and three-dimensional structures of such orphan ORFs, termed ORFans or poorly conserved ORFs (PCOs), is essential for understanding biodiversity. However, it has been claimed that many ORFans may not encode for expressed proteins. A genome-wide experimental study of 'paralogous PCOs' in the halophilic archaea Halobacterium sp. NRC-1 was conducted. Paralogous PCOs are ORFs with at least one homolog in the same organism, but with no clear homologs in other organisms. The results reveal that mRNA is synthesized for a majority of the Halobacterium sp. NRC-1 paralogous PCO families, including those comprising relatively short proteins, strongly suggesting that these Halobacterium sp. NRC-1 paralogous PCOs correspond to true, expressed proteins. Hence, further computational and experimental studies aimed at characterizing PCOs in this and other organisms are merited. Such efforts could shed light on PCOs' functions and origins, thereby serving to elucidate the vast diversity observed in the genetic material.

  5. MutS and MutL are dispensable for maintenance of the genomic mutation rate in the halophilic archaeon Halobacterium salinarum NRC-1.

    PubMed

    Busch, Courtney R; DiRuggiero, Jocelyne

    2010-02-04

    The genome of the halophilic archaeon Halobacterium salinarum NRC-1 encodes for homologs of MutS and MutL, which are key proteins of a DNA mismatch repair pathway conserved in Bacteria and Eukarya. Mismatch repair is essential for retaining the fidelity of genetic information and defects in this pathway result in the deleterious accumulation of mutations and in hereditary diseases in humans. We calculated the spontaneous genomic mutation rate of H. salinarum NRC-1 using fluctuation tests targeting genes of the uracil monophosphate biosynthesis pathway. We found that H. salinarum NRC-1 has a low incidence of mutation suggesting the presence of active mechanisms to control spontaneous mutations during replication. The spectrum of mutational changes found in H. salinarum NRC-1, and in other archaea, appears to be unique to this domain of life and might be a consequence of their adaption to extreme environmental conditions. In-frame targeted gene deletions of H. salinarum NRC-1 mismatch repair genes and phenotypic characterization of the mutants demonstrated that the mutS and mutL genes are not required for maintenance of the observed mutation rate. We established that H. salinarum NRC-1 mutS and mutL genes are redundant to an alternative system that limits spontaneous mutation in this organism. This finding leads to the puzzling question of what mechanism is responsible for maintenance of the low genomic mutation rates observed in the Archaea, which for the most part do not have MutS and MutL homologs.

  6. MutS and MutL Are Dispensable for Maintenance of the Genomic Mutation Rate in the Halophilic Archaeon Halobacterium salinarum NRC-1

    PubMed Central

    2010-01-01

    Background The genome of the halophilic archaeon Halobacterium salinarum NRC-1 encodes for homologs of MutS and MutL, which are key proteins of a DNA mismatch repair pathway conserved in Bacteria and Eukarya. Mismatch repair is essential for retaining the fidelity of genetic information and defects in this pathway result in the deleterious accumulation of mutations and in hereditary diseases in humans. Methodology/Principal Findings We calculated the spontaneous genomic mutation rate of H. salinarum NRC-1 using fluctuation tests targeting genes of the uracil monophosphate biosynthesis pathway. We found that H. salinarum NRC-1 has a low incidence of mutation suggesting the presence of active mechanisms to control spontaneous mutations during replication. The spectrum of mutational changes found in H. salinarum NRC-1, and in other archaea, appears to be unique to this domain of life and might be a consequence of their adaption to extreme environmental conditions. In-frame targeted gene deletions of H. salinarum NRC-1 mismatch repair genes and phenotypic characterization of the mutants demonstrated that the mutS and mutL genes are not required for maintenance of the observed mutation rate. Conclusions/Significance We established that H. salinarum NRC-1 mutS and mutL genes are redundant to an alternative system that limits spontaneous mutation in this organism. This finding leads to the puzzling question of what mechanism is responsible for maintenance of the low genomic mutation rates observed in the Archaea, which for the most part do not have MutS and MutL homologs. PMID:20140215

  7. NRC-BNL Benchmark Program on Evaluation of Methods for Seismic Analysis of Coupled Systems

    SciTech Connect

    Chokshi, N.; DeGrassi, G.; Xu, J.

    1999-03-24

    A NRC-BNL benchmark program for evaluation of state-of-the-art analysis methods and computer programs for seismic analysis of coupled structures with non-classical damping is described. The program includes a series of benchmarking problems designed to investigate various aspects of complexities, applications and limitations associated with methods for analysis of non-classically damped structures. Discussions are provided on the benchmarking process, benchmark structural models, and the evaluation approach, as well as benchmarking ground rules. It is expected that the findings and insights, as well as recommendations from this program will be useful in developing new acceptance criteria and providing guidance for future regulatory activities involving licensing applications of these alternate methods to coupled systems.

  8. NRC-BNL BENCHMARK PROGRAM ON EVALUATION OF METHODS FOR SEISMIC ANALYSIS OF COUPLED SYSTEMS.

    SciTech Connect

    XU,J.

    1999-08-15

    A NRC-BNL benchmark program for evaluation of state-of-the-art analysis methods and computer programs for seismic analysis of coupled structures with non-classical damping is described. The program includes a series of benchmarking problems designed to investigate various aspects of complexities, applications and limitations associated with methods for analysis of non-classically damped structures. Discussions are provided on the benchmarking process, benchmark structural models, and the evaluation approach, as well as benchmarking ground rules. It is expected that the findings and insights, as well as recommendations from this program will be useful in developing new acceptance criteria and providing guidance for future regulatory activities involving licensing applications of these alternate methods to coupled systems.

  9. Signs of life: Report of a NRC workshop on life detection

    NASA Astrophysics Data System (ADS)

    Lunine, J.

    Given the active interest in the astrobiological exploration of Mars, Europa, Titan, and other targets, it is timely to assess the state of life detection techniques for use on planetary surfaces and on samples returned to terrestrial laboratories. The Space Studies Board (SSB) charged the Committee for the Origin and Evolution of Life (COEL) which reports to both the SSB and the Board on Life SciencesUto organize a scientific workshop to explore advances in biology, biotechnology, medicine, and the environmental sciences likely to lead to new approaches to detecting life or its remnants. COEL, co-chaired by John Baross (U. Washington) and the presenter, held the workshop in April 2000 and published a report of the proceedings and resulting conclusions. This report is just now available on the NRC website and in hard copy, so I will summarize the major findings of the report and their implications for the detection of life on other solar system bodies.

  10. Canister storage building compliance assessment SNF project NRC equivalency criteria - HNF-SD-SNF-DB-003

    SciTech Connect

    BLACK, D.M.

    1999-08-11

    This document presents the Project's position on compliance with the SNF Project NRC Equivalency Criteria--HNF-SD-SNF-DE-003, Spent Nuclear Fuel Project Path Forward Additional NRC Requirements. No non-compliances are shown The compliance statements have been reviewed and approved by DOE. Open items are scheduled to be closed prior to project completion.

  11. 10 CFR 110.9 - List of Nuclear Material under NRC export licensing authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false List of Nuclear Material under NRC export licensing authority. 110.9 Section 110.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.9 List of Nuclear Material under NRC export licensing...

  12. 10 CFR 110.9 - List of Nuclear Material under NRC export licensing authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false List of Nuclear Material under NRC export licensing authority. 110.9 Section 110.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.9 List of Nuclear Material under NRC export licensing...

  13. 10 CFR 110.9 - List of Nuclear Material under NRC export licensing authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false List of Nuclear Material under NRC export licensing authority. 110.9 Section 110.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.9 List of Nuclear Material under NRC export licensing...

  14. 10 CFR 110.9 - List of Nuclear Material under NRC export licensing authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false List of Nuclear Material under NRC export licensing authority. 110.9 Section 110.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.9 List of Nuclear Material under NRC export licensing...

  15. Evaluating NRC's Recommendations for Educating Children with Autism a Decade Later

    ERIC Educational Resources Information Center

    Tincani, Matt; Cucchiarra, Maia Bloomfield; Thurman, S. Kenneth; Snyder, Mark R.; McCarthy, Catherine M.

    2014-01-01

    Background: Over a decade ago, the National Research Council (NRC) published the influential book, "Educating Children with Autism." Objective: To survey parents and state-level special education administrators to evaluate how NRC's recommendations, as published in "Educating Children with Autism," have impacted…

  16. The National Research Center on the Gifted and Talented (NRC/GT) Newsletter, 1999.

    ERIC Educational Resources Information Center

    Gubbins, E. Jean, Ed.; Siegle, Del, Ed.

    1999-01-01

    These two newsletters of The National Research Center on the Gifted and Talented (NRC/GT) present articles concerned with research on the education of gifted and talented students. The articles include: "NRC/GT: Making Decisions and Determining Next Steps" (E. Jean Gubbins); "Free Summer Programs for Talented Teens" (D. Betsy McCoach); "High End…

  17. 10 CFR 110.9 - List of Nuclear Material under NRC export licensing authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false List of Nuclear Material under NRC export licensing authority. 110.9 Section 110.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.9 List of Nuclear Material under NRC export...

  18. Developing the Gifts and Talents of All America's Students: NRC/GT--1990-1995.

    ERIC Educational Resources Information Center

    Gubbins, E. Jean; And Others

    This monograph discusses the organization and mission of the National Research Center on the Gifted and Talented (NRC/GT) and describes the research studies and commissioned papers that the Center has sponsored. Part 1, "Dream and Design for the NRC/GT," provides an overview of the Center as an organization and describes how the research…

  19. 10 CFR 51.104 - NRC proceeding using public hearings; consideration of environmental impact statement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... environmental impact statement. 51.104 Section 51.104 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED....104 NRC proceeding using public hearings; consideration of environmental impact statement. (a)(1) In... scope of NEPA and this subpart are in issue, the NRC staff may not offer the final environmental impact...

  20. Comparing the NRC and the Faculty Hiring Network Methods of Ranking Doctoral Programs in Communication

    ERIC Educational Resources Information Center

    Barnett, George A.; Feeley, Thomas Hugh

    2011-01-01

    The current analysis examines the relationship between measures (R-scores, S-scores, faculty productivity) utilized in the recently published National Research Council NRC report and communication doctoral programs' centrality in the faculty-hiring network. Correlations among the network indicators and the NRC ratings were generally moderate and…

  1. 10 CFR 14.15 - Where to present a claim to NRC.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Where to present a claim to NRC. 14.15 Section 14.15 Energy NUCLEAR REGULATORY COMMISSION ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT Filing Procedures and Requirements § 14.15 Where to present a claim to NRC. A claimant shall mail or deliver the...

  2. 77 FR 36583 - NRC Form 5, Occupational Dose Record for a Monitoring Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ... COMMISSION NRC Form 5, Occupational Dose Record for a Monitoring Period AGENCY: Nuclear Regulatory Commission... Monitoring Period.'' The current NRC Form 5 is being revised to align with current regulations. We are... Form 5, ``Occupational Dose Record for a Monitoring Period,'' or in an equivalent paper or electronic...

  3. 10 CFR 10.32 - Recommendation of the NRC Personnel Security Review Panel.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Recommendation of the NRC Personnel Security Review Panel. 10.32 Section 10.32 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING... Procedures § 10.32 Recommendation of the NRC Personnel Security Review Panel. (a) The Deputy...

  4. 10 CFR 10.32 - Recommendation of the NRC Personnel Security Review Panel.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Recommendation of the NRC Personnel Security Review Panel. 10.32 Section 10.32 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING... Procedures § 10.32 Recommendation of the NRC Personnel Security Review Panel. (a) The Deputy...

  5. 10 CFR 10.32 - Recommendation of the NRC Personnel Security Review Panel.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Recommendation of the NRC Personnel Security Review Panel. 10.32 Section 10.32 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING... Procedures § 10.32 Recommendation of the NRC Personnel Security Review Panel. (a) The Deputy...

  6. 10 CFR 10.32 - Recommendation of the NRC Personnel Security Review Panel.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Recommendation of the NRC Personnel Security Review Panel. 10.32 Section 10.32 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING... Procedures § 10.32 Recommendation of the NRC Personnel Security Review Panel. (a) The Deputy...

  7. 10 CFR 10.32 - Recommendation of the NRC Personnel Security Review Panel.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Recommendation of the NRC Personnel Security Review Panel. 10.32 Section 10.32 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING... Procedures § 10.32 Recommendation of the NRC Personnel Security Review Panel. (a) The Deputy...

  8. 10 CFR 2.1403 - Authority and role of the NRC staff.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Authority and role of the NRC staff. 2.1403 Section 2.1403 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Expedited Proceedings with Oral Hearings § 2.1403 Authority and role of the NRC staff. (a) During...

  9. 10 CFR 2.1316 - Authority and role of NRC staff.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Authority and role of NRC staff. 2.1316 Section 2.1316 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Procedures for Hearings on License Transfer Applications § 2.1316 Authority and role of NRC staff...

  10. The National Research Center on the Gifted and Talented (NRC/GT) Newsletter, 1998.

    ERIC Educational Resources Information Center

    Gubbins, E. Jean, Ed.; Siegle, Del, Ed.

    1998-01-01

    These two newsletters of The National Research Center on the Gifted and Talented (NRC/GT) present articles concerned with research on the education of gifted and talented students. The articles are: "NRC/GT's Suggestions: Evaluating Your Programs and Services" (E. Jean Gubbins); "Professional Development Practices in Gifted Education: Results of a…

  11. NRC Regulatory Agenda semiannual report, July--December 1995. Volume 14, No. 2

    SciTech Connect

    1996-02-01

    The NRC Regulatory Agenda is a compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and all petitions for rulemaking which have been received by the Commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued semianually.

  12. NRC Regulatory Agenda quarterly report, July--September 1993. Volume 12, No. 3

    SciTech Connect

    Not Available

    1993-10-01

    The NRC Regulator Agenda is a compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and all petitions for rulemaking which have been received by the commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued each quarter.

  13. NRC regulatory agenda: Semiannual report, July--December 1996. Volume 15, Number 2

    SciTech Connect

    1997-03-01

    The NRC Regulatory Agenda is a compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and all petitions for rulemaking which have been received by the Commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued semiannually.

  14. 10 CFR 81.13 - Publication of NRC inventions available for licensing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Publication of NRC inventions available for licensing. 81.13 Section 81.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) STANDARD SPECIFICATIONS FOR THE GRANTING OF PATENT LICENSES Nrc-Owned Inventions-Patents and Applications § 81.13 Publication of...

  15. 10 CFR 81.13 - Publication of NRC inventions available for licensing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Publication of NRC inventions available for licensing. 81.13 Section 81.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) STANDARD SPECIFICATIONS FOR THE GRANTING OF PATENT LICENSES Nrc-Owned Inventions-Patents and Applications § 81.13 Publication of...

  16. 10 CFR 81.13 - Publication of NRC inventions available for licensing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Publication of NRC inventions available for licensing. 81.13 Section 81.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) STANDARD SPECIFICATIONS FOR THE GRANTING OF PATENT LICENSES Nrc-Owned Inventions-Patents and Applications § 81.13 Publication of...

  17. 10 CFR 81.13 - Publication of NRC inventions available for licensing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Publication of NRC inventions available for licensing. 81.13 Section 81.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) STANDARD SPECIFICATIONS FOR THE GRANTING OF PATENT LICENSES Nrc-Owned Inventions-Patents and Applications § 81.13 Publication of...

  18. Roadmap to NRC Approval of Ceramic Matrix Composites in Generation IV Reactors

    SciTech Connect

    M. G. Jenkins; E. Lara-Curzio; W. Windes

    2006-05-01

    This report provides an initial roadmap to obtain Nuclear Regulatory Commission (NRC) approval for using these material systems in a nuclear application. The possible paths taken to achieving NRC approval are necessarily subject to change as this is an on-going process that shifts as more data and a clearer understanding of the nuclear regulations are gathered.

  19. Evaluating NRC's Recommendations for Educating Children with Autism a Decade Later

    ERIC Educational Resources Information Center

    Tincani, Matt; Cucchiarra, Maia Bloomfield; Thurman, S. Kenneth; Snyder, Mark R.; McCarthy, Catherine M.

    2014-01-01

    Background: Over a decade ago, the National Research Council (NRC) published the influential book, "Educating Children with Autism." Objective: To survey parents and state-level special education administrators to evaluate how NRC's recommendations, as published in "Educating Children with Autism," have impacted…

  20. Comparing the NRC and the Faculty Hiring Network Methods of Ranking Doctoral Programs in Communication

    ERIC Educational Resources Information Center

    Barnett, George A.; Feeley, Thomas Hugh

    2011-01-01

    The current analysis examines the relationship between measures (R-scores, S-scores, faculty productivity) utilized in the recently published National Research Council NRC report and communication doctoral programs' centrality in the faculty-hiring network. Correlations among the network indicators and the NRC ratings were generally moderate and…

  1. 10 CFR 52.83 - Finality of referenced NRC approvals; partial initial decision on site suitability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Finality of referenced NRC approvals; partial initial decision on site suitability. 52.83 Section 52.83 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.83 Finality of referenced NRC...

  2. 10 CFR 52.83 - Finality of referenced NRC approvals; partial initial decision on site suitability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Finality of referenced NRC approvals; partial initial decision on site suitability. 52.83 Section 52.83 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.83 Finality of referenced NRC...

  3. 10 CFR 52.83 - Finality of referenced NRC approvals; partial initial decision on site suitability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Finality of referenced NRC approvals; partial initial decision on site suitability. 52.83 Section 52.83 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.83 Finality of referenced NRC...

  4. 10 CFR 52.83 - Finality of referenced NRC approvals; partial initial decision on site suitability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Finality of referenced NRC approvals; partial initial decision on site suitability. 52.83 Section 52.83 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.83 Finality of referenced NRC...

  5. 10 CFR 52.83 - Finality of referenced NRC approvals; partial initial decision on site suitability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Finality of referenced NRC approvals; partial initial decision on site suitability. 52.83 Section 52.83 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.83 Finality of referenced NRC...

  6. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC...

  7. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC...

  8. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC...

  9. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC...

  10. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC...

  11. Structural basis for salt-dependent folding of ribonuclease H1 from halophilic archaeon Halobacterium sp. NRC-1.

    PubMed

    You, Dong-Ju; Jongruja, Nujarin; Tannous, Elias; Angkawidjaja, Clement; Koga, Yuichi; Kanaya, Shigenori

    2014-08-01

    RNase H1 from extreme halophilic archaeon Halobacterium sp. NRC-1 (Halo-RNase H1) requires ⩾2M NaCl, ⩾10mM MnCl2, or ⩾300mM MgCl2 for folding. To understand the structural basis for this salt-dependent folding of Halo-RNase H1, the crystal structure of Halo-RNase H1 was determined in the presence of 10mM MnCl2. The structure of Halo-RNase H1 highly resembles those of metagenome-derived LC11-RNase H1 and Sulfolobus tokodaii RNase H1 (Sto-RNase H1), except that it contains two Mn(2+) ions at the active site and has three bi-aspartate sites on its surface. To examine whether negative charge repulsion at these sites are responsible for low-salt denaturation of Halo-RNase H1, a series of the mutant proteins of Halo-RNase H1 at these sites were constructed. The far-UV CD spectra of these mutant proteins measured in the presence of various concentrations of NaCl suggest that these mutant proteins exist in an equilibrium between a partially folded state and a folded state. However, the fraction of the protein in a folded state is nearly 0% for the active site mutant, 40% for the bi-aspartate site mutant, and 70% for the mutant at both sites in the absence of salt. The active site mutant requires relatively low concentration (∼0.5M) of salt for folding. These results suggest that suppression of negative charge repulsion at both active and bi-aspartate sites by salt is necessary to yield a folded protein. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. Summary of Chernobyl followup research activities

    SciTech Connect

    Not Available

    1992-06-01

    In NUREG-1251, ``Implications of the Accident at Chernobyl for Safety Regulation of Commercial Nuclear Power Plants in the United States,`` April 1989, the NRC staff concluded that no immediate changes in NRC`s regulations regarding design or operation of US commercial reactors were needed; however, it recommended that certain issues be considered further. NRC`s Chernobyl followup research program consisted of the research tasks undertaken in response to the recommendations in NUREG-1251. It included 23 tasks that addressed potential lessons to be learned from the Chernobyl accident. This report presents summaries of NRC`s Chernobyl followup research tasks. For each task, the Chernobyl-related issues are indicated, the work is described, and the staff`s findings and conclusions are presented. More detailed reports concerning the work are referenced where applicable. This report closes out NRC`s Chernobyl followup research program as such, but additional research will be conducted on some issues as needed. The report includes remarks concerning significant further activity with respect to the issues addressed.

  13. Summary of Chernobyl followup research activities

    SciTech Connect

    Not Available

    1992-06-01

    In NUREG-1251, Implications of the Accident at Chernobyl for Safety Regulation of Commercial Nuclear Power Plants in the United States,'' April 1989, the NRC staff concluded that no immediate changes in NRC's regulations regarding design or operation of US commercial reactors were needed; however, it recommended that certain issues be considered further. NRC's Chernobyl followup research program consisted of the research tasks undertaken in response to the recommendations in NUREG-1251. It included 23 tasks that addressed potential lessons to be learned from the Chernobyl accident. This report presents summaries of NRC's Chernobyl followup research tasks. For each task, the Chernobyl-related issues are indicated, the work is described, and the staff's findings and conclusions are presented. More detailed reports concerning the work are referenced where applicable. This report closes out NRC's Chernobyl followup research program as such, but additional research will be conducted on some issues as needed. The report includes remarks concerning significant further activity with respect to the issues addressed.

  14. A Summary of NRC Findings and Recommendations on International Collaboration in Space Exploration

    NASA Astrophysics Data System (ADS)

    Moloney, Michael; Smith, David H.; Graham, Sandra

    Collaboration among the world’s space agencies has become an essential tool to achieving shared goals in the exploration of space. In space science international coordination and collaborations have formed the foundation of advances in our knowledge of our universe over the last few decades. In support of the U.S. space science and Earth science programs, NASA has engaged in well over 1000 international activities with many nations. Indeed, international participation in NASA science missions has more often been the norm rather than the exception. Among notable recent examples are the Hubble Space Telescope (with ESA), the Cassini-Huygens Saturn mission (with ESA and Italy), the James Webb Space Telescope (with ESA and Canada) and of course the International Space Station (with Russia, ESA, Japan, and Canada). However, the international character of a space mission is no guarantee of its successful realization. International collaboration can be sidetracked owing to developments in national programs or budgets and the management challenges cannot be understated. In human spaceflight international coordination and collaboration started in earnest with the Apollo-Soyuz program in the 1970s and today it forms the foundation of the successful International Space Station partnership that is likely to continue through into the early 2020s. But what role will international collaboration play in human spaceflight beyond low Earth orbit in the decades ahead? This paper will discuss the findings and recommendations of a number of NRC reports that have considered international collaboration. For instance the 1998 U.S. National Research Council (NRC) / European Science Foundation report “U.S.-European Collaboration in Space Science” found, cooperative programs depend on a clear understanding of how the responsibilities of the mission are to be shared among the partners, a clear management scheme with a well defined interface between the parties, and efficient

  15. Circular dichroism and fluorescence spectroscopy of cysteinyl-tRNA synthetase from Halobacterium salinarum ssp. NRC-1 demonstrates that group I cations are particularly effective in providing structure and stability to this halophilic protein.

    PubMed

    Reed, Christopher J; Bushnell, Sarah; Evilia, Caryn

    2014-01-01

    Proteins from extremophiles have the ability to fold and remain stable in their extreme environment. Here, we investigate the presence of this effect in the cysteinyl-tRNA synthetase from Halobacterium salinarum ssp. NRC-1 (NRC-1), which was used as a model halophilic protein. The effects of salt on the structure and stability of NRC-1 and of E. coli CysRS were investigated through far-UV circular dichroism (CD) spectroscopy, fluorescence spectroscopy, and thermal denaturation melts. The CD of NRC-1 CysRS was examined in different group I and group II chloride salts to examine the effects of the metal ions. Potassium was observed to have the strongest effect on NRC-1 CysRS structure, with the other group I salts having reduced strength. The group II salts had little effect on the protein. This suggests that the halophilic adaptations in this protein are mediated by potassium. CD and fluorescence spectra showed structural changes taking place in NRC-1 CysRS over the concentration range of 0-3 M KCl, while the structure of E. coli CysRS was relatively unaffected. Salt was also shown to increase the thermal stability of NRC-1 CysRS since the melt temperature of the CysRS from NRC-1 was increased in the presence of high salt, whereas the E. coli enzyme showed a decrease. By characterizing these interactions, this study not only explains the stability of halophilic proteins in extremes of salt, but also helps us to understand why and how group I salts stabilize proteins in general.

  16. Circular Dichroism and Fluorescence Spectroscopy of Cysteinyl-tRNA Synthetase from Halobacterium salinarum ssp. NRC-1 Demonstrates that Group I Cations Are Particularly Effective in Providing Structure and Stability to This Halophilic Protein

    PubMed Central

    Reed, Christopher J.; Bushnell, Sarah; Evilia, Caryn

    2014-01-01

    Proteins from extremophiles have the ability to fold and remain stable in their extreme environment. Here, we investigate the presence of this effect in the cysteinyl-tRNA synthetase from Halobacterium salinarum ssp. NRC-1 (NRC-1), which was used as a model halophilic protein. The effects of salt on the structure and stability of NRC-1 and of E. coli CysRS were investigated through far-UV circular dichroism (CD) spectroscopy, fluorescence spectroscopy, and thermal denaturation melts. The CD of NRC-1 CysRS was examined in different group I and group II chloride salts to examine the effects of the metal ions. Potassium was observed to have the strongest effect on NRC-1 CysRS structure, with the other group I salts having reduced strength. The group II salts had little effect on the protein. This suggests that the halophilic adaptations in this protein are mediated by potassium. CD and fluorescence spectra showed structural changes taking place in NRC-1 CysRS over the concentration range of 0–3 M KCl, while the structure of E. coli CysRS was relatively unaffected. Salt was also shown to increase the thermal stability of NRC-1 CysRS since the melt temperature of the CysRS from NRC-1 was increased in the presence of high salt, whereas the E. coli enzyme showed a decrease. By characterizing these interactions, this study not only explains the stability of halophilic proteins in extremes of salt, but also helps us to understand why and how group I salts stabilize proteins in general. PMID:24594651

  17. Active region helicity evolution and related coronal mass ejection activity.

    NASA Astrophysics Data System (ADS)

    Green, L.; Mandrini, C.; van Driel-Gesztelyi, L.; Demoulin, P.

    The computation of magnetic helicity has become increasingly important in the studies of solar activity. Observations of helical structures in the solar atmosphere, and their subsequent ejection into the interplanetary medium, have resulted in considerable interest to find the link between the amount of helicity in the coronal magnetic field and the origin of coronal mass ejections (CMEs). This is reinforced by theory which shows magnetic helicity to be a well preserved quantity (Berger, 1984), and so with a continued injection into the corona an endless accumulation will occur. CMEs therefore provide a natural method to remove helicity from the corona. Recent works (DeVore, 2000, Chae, 2001, Chae et al., 2001, Demoulin et al., 2002, Green et al., 2002) have endeavoured to find the source of helicity in the corona to explain the observed CME activity in specific cases. The main candidates being differential rotation, shear motions or a transfer of helicity from below the photosphere into the corona. In order to establish a confident relation between CMEs and helicity, these works needs to be expanded to include CME source regions with different characteristics. A study of a very different active region will be presented and the relationship between helicity content and CME activity will be discussed in the framework of the previous studies.

  18. The National Research Center on the Gifted and Talented (NRC/GT) Newsletter. Fall 1994-Spring 1995.

    ERIC Educational Resources Information Center

    Gubbins, E. Jean, Ed.; Siegle, Del, Ed.

    1995-01-01

    This document consists of three consecutive but unnumbered issues of a newsletter from the National Research Center on the Gifted and Talended (NRC/GT) containing articles on the education of gifted and talented students: "NRC/GT Destination: Around the Corner" (E. Jean Gubbins); "New NRC/GT Studies for Year 5" (on implementing enrichment…

  19. Heterologous overexpression, purification and characterisation of an alcohol dehydrogenase (ADH2) from Halobacterium sp. NRC-1.

    PubMed

    Liliensiek, Ann-Kathrin; Cassidy, Jennifer; Gucciardo, Gabriele; Whitely, Cliadhna; Paradisi, Francesca

    2013-10-01

    Replacement of chemical steps with biocatalytic ones is becoming increasingly more interesting due to the remarkable catalytic properties of enzymes, such as their wide range of substrate specificities and variety of chemo-, stereo- and regioselective reactions. This study presents characterisation of an alcohol dehydrogenase (ADH) from the halophilic archaeum Halobacterium sp. NRC-1 (HsADH2). A hexahistidine-tagged recombinant version of HsADH2 (His-HsADH2) was heterologously overexpressed in Haloferax volcanii. The enzyme was purified in one step by immobilised Ni-affinity chromatography. His-HsADH2 was halophilic and mildly thermophilic with optimal activity for ethanol oxidation at 4 M KCl around 60 °C and pH 10.0. The enzyme was extremely stable, retaining 80 % activity after 30 days. His-HsADH2 showed preference for NADP(H) but interestingly retained 60 % activity towards NADH. The enzyme displayed broad substrate specificity, with maximum activity obtained for 1-propanol. The enzyme also accepted secondary alcohols such as 2-butanol and even 1-phenylethanol. In the reductive reaction, working conditions for His-HsADH2 were optimised for acetaldehyde and found to be 4 M KCl and pH 6.0. His-HsADH2 displayed intrinsic organic solvent tolerance, which is highly relevant for biotechnological applications.

  20. ABC transporter for corrinoids in Halobacterium sp. strain NRC-1.

    PubMed

    Woodson, Jesse D; Reynolds, April A; Escalante-Semerena, Jorge C

    2005-09-01

    We report evidence for the existence of a putative ABC transporter for corrinoid utilization in the extremely halophilic archaeon Halobacterium sp. strain NRC-1. Results from genetic and nutritional analyses of Halobacterium showed that mutants with lesions in open reading frames (ORFs) Vng1370G, Vng1371Gm, and Vng1369G required a 10(5)-fold higher concentration of cobalamin for growth than the wild-type or parent strain. The data support the conclusion that these ORFs encode orthologs of the bacterial cobalamin ABC transporter permease (btuC; Vng1370G), ATPase (btuD; Vng1371Gm), and substrate-binding protein (btuF; Vng1369G) components. Mutations in the Vng1370G, Vng1371Gm, and Vng1369G genes were epistatic, consistent with the hypothesis that their products work together to accomplish the same function. Extracts of btuF mutant strains grown in the presence of cobalamin did not contain any cobalamin molecules detectable by a sensitive bioassay, whereas btuCD mutant strain extracts did. The data are consistent with the hypothesis that the BtuF protein is exported to the extracellular side of the cell membrane, where it can bind cobalamin in the absence of BtuC and BtuD. Our data also provide evidence for the regulation of corrinoid transport and biosynthesis. Halobacterium synthesized cobalamin in a chemically defined medium lacking corrinoid precursors. To the best of our knowledge, this is the first genetic analysis of an archaeal corrinoid transport system.

  1. Soil hazards related to shale gas activities

    NASA Astrophysics Data System (ADS)

    Konieczyńska, Monika; Lipińska, Olga

    2017-04-01

    In 2010-2015 dozen of unconventional hydrocarbons wells were drilled in Poland. These earliest cases of new industrial activity in Europe were carefully observed and monitored both by the society and scientific community. One of the biggest and most comprehensive researches on environmental impact posed by the activity was the one conducted by a scientific consortium led by the PGI-NRI. The outcomes of this study are still relevant as a basic data for environmental impact assessment and ought to be more widely used for analysis and comparisons as they documented real case studies involving local factors and conditions. With this presentation, issues related to soil will be discussed, including sub-soil compaction (due to overburden from infrastructure and topsoil temporary storage heaps) as well as contamination by accidental spills of chemicals and technological fluids. Both chemical and agricultural properties of soils have been tested. Within the study, contents of methane and others light hydrocarbons in soil gas were considered as possible indicators of stray gases migration towards the land surface from deeper formations. Thus, such gases survey was conducted with concentrations as well as isotopic characteristics analysis. According to the results a peculiar and unexpected phenomenon of increased methane concentration under site protective impermeable coverage were observed. It is supposed to be caused by a mix of local geological conditions and land-use pattern. Based on real study results a need for baseline conditions establishment as well as continuous soil properties monitoring is needed in order to protect the soil itself as well as to have a tool for unwanted substances migration indicator. For both purposes proper sampling strategy recommendation need to be elaborated.

  2. Relating practitioner needs to research activities

    NASA Technical Reports Server (NTRS)

    Feather, M. S.; Menzies, T.; Connelly, J. R.

    2003-01-01

    We present an approach to matching needs (practioner requirements) to solutions (researcher activities). A taxonomical classification scheme acts as intermediary between needs and activities. Expert practitioners exprss their needs in terms of this taxonomy. Researchers express their activities in the same terms. A decision support tool is used to assist in the combination and study of their expressions of needs and activities.

  3. 18 CFR 1316.8 - Employee protected activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... discrimination against employees for engaging in certain protected activities. The Secretary of Labor has determined that “discrimination” means discharge or any other adverse actions that relate to compensation... employer or to the NRC. Contractor shall aggressively pursue any employee allegation of discrimination...

  4. 10 CFR 2.1316 - Authority and role of NRC staff.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... License Transfer Applications § 2.1316 Authority and role of NRC staff. (a) During the pendency of any...), the staff is expected to promptly issue approval or denial of license transfer requests. Notice...

  5. 10 CFR 2.1316 - Authority and role of NRC staff.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... License Transfer Applications § 2.1316 Authority and role of NRC staff. (a) During the pendency of any...), the staff is expected to promptly issue approval or denial of license transfer requests. Notice...

  6. 10 CFR 2.1316 - Authority and role of NRC staff.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS Procedures for Hearings on License Transfer Applications § 2.1316 Authority and role of NRC staff... license transfer requests. Notice of such action shall be promptly transmitted to the Presiding...

  7. NRC regulatory agenda: Semiannual report, January--June 1997. Volume 16, Number 1

    SciTech Connect

    1997-08-01

    The Regulatory Agenda is a semiannual compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and of all petitions for rulemaking that the NRC has received that are pending disposition. The agenda consists of two sections that have been updated through June 30, 1997. Section 1, ``Rules,`` includes (A) rules on which final action has been taken since December 31, 1996, the closing date of the last NRC Regulatory Agenda; (B) rules published previously as proposed rules on which the Commission has not taken final action; (C) rules published as advance notices of proposed rulemaking for which neither a proposed nor final rule has been issued; and (D) unpublished rules on which the NRC expects to take action. Section 2, ``Petitions for Rulemaking,`` includes (A) petitions denied or incorporated into final rules since December 31, 1996; (B) petitions incorporated into proposed rules; and (C) petitions pending staff review.

  8. Spent Nuclear Fuel Project path forward: nuclear safety equivalency to comparable NRC-licensed facilities

    SciTech Connect

    Garvin, L.J.

    1995-11-01

    This document includes the Technical requirements which meet the nuclear safety objectives of the NRC regulations for fuel treatment and storage facilities. These include requirements regarding radiation exposure limits, safety analysis, design and construction. This document also includes administrative requirements which meet the objectives of the major elements of the NRC licensing process. These include formally documented design and safety analysis, independent technical review, and oppportunity for public involvement.

  9. Nucleotide fluctuation of radiation-resistant Halobacterium sp. NRC-1 single-stranded DNA-binding protein (RPA) genes

    NASA Astrophysics Data System (ADS)

    Holden, Todd; Tremberger, G., Jr.; Cheung, E.; Subramaniam, R.; Gadura, N.; Schneider, P.; Sullivan, R.; Flamholz, A.; Lieberman, D.; Cheung, T. D.

    2009-08-01

    The Single-Stranded DNA-Binding Protein (RPA) Genes in gamma ray radiation-resistant halophilic archaeon Halobacterium sp. NRC-1 were analyzed in terms of their nucleotide fluctuations. In an ATCG sequence, each base was assigned a number equal to its atomic number. The resulting numerical sequence was the basis of the statistical analysis in this study. Fractal analysis using the Higuchi method gave fractal dimensions of 2.04 and 2.06 for the gene sequences VNG2160 and VNG2162, respectively. The 16S rRNA sequence has a fractal dimension of 1.99. The di-nucleotide Shannon entropy values were found to be negatively correlated with the observed fractal dimensions (R2~ 0.992, N=3). Inclusion of Deinococcus radiodurans Rad-A in the regression analysis decreases the R2 slightly to 0.98 (N=4). A third VNG2163 RPA gene of unknown function but with upregulation activity under irradiation was found to have a fractal dimension of 2.05 and a Shannon entropy of 3.77 bits. The above results are similar to those found in bacterial Deinococcus radiodurans and suggest that their high radiation resistance property would have favored selection of CG di-nucleotide pairs. The two transcription factors TbpD (VNG7114) and TfbA (VNG 2184) were also studied. Using VNG7114, VNG2184, and VNG2163; the regression analysis of fractal dimension versus Shannon entropy shows that R2 ~ 0.997 for N =3. The VNG2163 unknown function may be related to the pathways with transcriptions closely regulated to sequences VNG7114 and VNG2184.

  10. HFE Process Guidance and Standards for potential application to updating NRC guidance

    SciTech Connect

    Jacques Hugo; J. J. Persensky

    2012-07-01

    The U.S. Nuclear Regulatory Commission (NRC) reviews and evaluates the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of these guidance documents to ensure that they remain state-of-the-art design evaluation tools. Thus, the NRC has initiated a project with BNL to update the NRC guidance to remain current with recent research on human performance, advances in HFE methods and tools, and new technology. INL supported Brookhaven National Lab (BNL) to update the detailed HFE review criteria contained in NUREG-0711 and NUREG-0700 based on (1) feedback obtained from end users, (2) the results of NRC research and development efforts supporting the NRC staff’s HFE safety reviews, and (3) other material the project staff identify as applicable to the update effort. INL submitted comments on development plans and sections of NUREGs 0800, 0711, and 0700. The contractor prepared the report attached here as the deliverable for this work.

  11. 29 CFR 779.207 - Related activities in retail operations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Related activities in retail operations. 779.207 Section... Coverage Related Activities § 779.207 Related activities in retail operations. In the case of an enterprise which has one or more retail or service establishments, all of the activities which are performed for...

  12. 29 CFR 779.207 - Related activities in retail operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Related activities in retail operations. 779.207 Section... Coverage Related Activities § 779.207 Related activities in retail operations. In the case of an enterprise which has one or more retail or service establishments, all of the activities which are performed for...

  13. 29 CFR 779.207 - Related activities in retail operations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Related activities in retail operations. 779.207 Section... Coverage Related Activities § 779.207 Related activities in retail operations. In the case of an enterprise which has one or more retail or service establishments, all of the activities which are performed for...

  14. 29 CFR 779.207 - Related activities in retail operations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Related activities in retail operations. 779.207 Section... Coverage Related Activities § 779.207 Related activities in retail operations. In the case of an enterprise which has one or more retail or service establishments, all of the activities which are performed for...

  15. 29 CFR 779.207 - Related activities in retail operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Related activities in retail operations. 779.207 Section... Coverage Related Activities § 779.207 Related activities in retail operations. In the case of an enterprise which has one or more retail or service establishments, all of the activities which are performed for...

  16. Tsunami related to solar and geomagnetic activity

    NASA Astrophysics Data System (ADS)

    Cataldi, Gabriele; Cataldi, Daniele; Straser, Valentino

    2016-04-01

    The authors of this study wanted to verify the existence of a correlation between earthquakes of high intensity capable of generating tsunami and variations of solar and Earth's geomagnetic activity. To confirming or not the presence of this kind of correlation, the authors analyzed the conditions of Spaceweather "near Earth" and the characteristics of the Earth's geomagnetic field in the hours that preceded the four earthquakes of high intensity that have generated tsunamis: 1) Japan M9 earthquake occurred on March 11, 2011 at 05:46 UTC; 2) Japan M7.1 earthquake occurred on October 25, 2013 at 17:10 UTC; 3) Chile M8.2 earthquake occurred on April 1, 2014 at 23:46 UTC; 4) Chile M8.3 earthquake occurred on September 16, 2015 at 22:54 UTC. The data relating to the four earthquakes were provided by the United States Geological Survey (USGS). The data on ion density used to realize the correlation study are represented by: solar wind ion density variation detected by ACE (Advanced Composition Explorer) Satellite, in orbit near the L1 Lagrange point, at 1.5 million of km from Earth, in direction of the Sun. The instrument used to perform the measurement of the solar wind ion density is the Electron, Proton, and Alpha Monitor (EPAM) instrument, equipped on the ACE Satellite. To conduct the study, the authors have taken in consideration the variation of the solar wind protons density of three different energy fractions: differential proton flux 1060-1900 keV (p/cm^2-sec-ster-MeV); differential proton flux 761-1220 keV (p/cm^2-sec-ster-MeV); differential proton flux 310-580 keV (p/cm^2-sec-ster-MeV). Geomagnetic activity data were provided by Tromsø Geomagnetic Observatory (TGO), Norway; by Scoresbysund Geomagnetic Observatory (SCO), Greenland, Denmark and by Space Weather Prediction Center of Pushkov Institute of terrestrial magnetism, ionosphere and radio wave propagation (IZMIRAN), Troitsk, Moscow Region. The results of the study, in agreement with what already

  17. Purification and partial characterization of serine-metallokeratinase from a newly isolated Bacillus pumilus NRC21.

    PubMed

    Tork, Sanaa E; Shahein, Yasser E; El-Hakim, Amr E; Abdel-Aty, Azza M; Aly, Magda M

    2016-05-01

    A serine metallokeratinase enzyme (30 kDa) produced by a newly isolated Bacillus strain (Bacillus pumilus NRC21) cultivated under optimized conditions in medium containing chicken feather meal was purified and characterized in a set of biochemical assays. The purification was carried out using two successive chromatographic steps; cation exchange chromatography on CM-cellulose and gel filtration on sephadex G-100 columns. The purified enzyme showed a specific activity of 2000 units/mg protein against 170 units/mg protein for crude extract with 12 fold purification. The enzymatic activity of the keratinase stimulated by (Na(+), K(+), Mg(2+)), Hg(+2) had no effect, and inhibited by entire tested cations, serine and metalloproteinase inhibitors, therefore it can be considered as a serine metalloenzyme. The optimum pH and temperature for the purified enzyme were (7.5, 8.5) and (50, 45 °C) when using keratin azure and azocasein as substrates, respectively. The purified enzyme was highly stable at broad pH and temperature ranged (5-10) and (20-60 °C), respectively and its thermoactivity and thermostability were enhanced in the presence of 5 mM Mg(+2). These results suggest that the purified keratinase may be used in several industrial applications. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Data Quality Assurance Program Plan for NRC Division of Risk Analysis Programs at the INL

    SciTech Connect

    Sattison, Martin B.; Wierman, Thomas E.; Vedros, Kurt G.; Germain, Shawn W. St.; Eide, Steven A.; Sant, Robert L.

    2009-07-01

    The Division of Risk Analysis (DRA), Office of Nuclear Regulatory Research (RES), must ensure that the quality of the data that feed into its programs follow Office of Management and Budget (OMB) and U.S. Nuclear Regulatory Commission (NRC) guidelines and possibly other standards and guidelines used in nuclear power plant risk analyses. This report documents the steps taken in DRA’s Data Quality Improvement project (Job Control Number N6145) to develop a Data Quality Assurance Program Plan. These steps were 1. Conduct a review of data quality requirements 2. Review current data programs, products, and data quality control activities 3. Review the Institute of Nuclear Power Operation (INPO) Equipment Performance and Information Exchange (EPIX) data quality programs and characterize the EPIX data quality and uncertainty 4. Compare these programs, products, and activities against the requirements 5. Develop a program plan that provides assurance that data quality is being maintained. It is expected that the Data Quality Assurance Program Plan will be routinely implemented in all aspects of future data collection and processing efforts and that specific portions will be executed annually to provide assurance that data quality is being maintained.

  19. Evaluation of free and immobilized Aspergillus niger NRC1ami pectinase applicable in industrial processes.

    PubMed

    Esawy, Mona A; Gamal, Amira A; Kamel, Zeinat; Ismail, Abdel-Mohsen S; Abdel-Fattah, Ahmed F

    2013-02-15

    The Aspergillus niger NRC1ami pectinase was evaluated according to its hydrolysis efficiency of dry untreated orange peels (UOP), HCl-treated orange peels and NaOH-treated orange peels (HOP and NOP). Pectinase was entrapped in polyvinyl alcohol (PVA) sponge and the optimum pH and temperature of the free and immobilized enzymes were shifted from 4, 40 °C to 6, 50 °C respectively. The study of pH stability of free and immobilized pectinase showed that the immobilization process protected the enzyme strongly from severe alkaline pHs. The immobilization process improved the enzyme thermal stability to great instant. The unique feature of the immobilization process is its ability to solve the orange juice haze problem completely. Immobilized enzyme was reused 12 times in orange juice clarification with 9% activity loss from the original activity. Maximum reaction rate (V(max)) and Michaelis-Menten constant (K(m)) of the partially purified form were significantly changed after immobilization.

  20. Regulatory Activities Related to Circumferential Cracking of Reactor Pressure Vessel Head Penetration Nozzles

    SciTech Connect

    Hiser, Allen L. Jr.

    2002-07-01

    The recent discoveries of cracked and leaking Alloy 600 vessel head penetration (VHP) nozzles, including control rod drive mechanism (CRDM) and thermocouple nozzles, at four pressurized water reactors (PWRs) have raised concerns about the structural integrity of VHP nozzles throughout the PWR industry. Nozzle cracking at Oconee Nuclear Station Unit 1 in November 2000 and Arkansas Nuclear One Unit 1 in February 2001 was limited to axial cracking, an occurrence deemed to be of limited safety concern in the NRC staff's generic safety evaluation on the cracking of VHP nozzles dated November 19, 1993. However, the discovery of circumferential cracking at Oconee Nuclear Station Unit 3 in February 2001 and Oconee Nuclear Station Unit 2 in April 2001 particularly the large circumferential cracking identified in two CRDM nozzles at ONS3 has raised concerns about the potential safety implications and prevalence of cracking in VHP nozzles in PWRs. In response to the circumferential cracking identified at the Oconee units, the NRC issued Bulletin 2001-01, 'Circumferential Cracking of Reactor Pressure Vessel Head Penetration Nozzles', on August 3, 2001. This bulletin requests information from licensees related to the structural integrity of the reactor pressure VHP nozzles for their facilities, including the extent of VHP nozzle leakage and cracking that has been found to date, the inspections and repairs that have been undertaken to satisfy applicable regulatory requirements, future plans to inspect VHP nozzles, and a description of how future inspection plans will ensure compliance with applicable regulatory requirements. This paper summarizes the staff's review and assessment of licensee responses to NRC Bulletin 2001-01. (author)

  1. Planetary Protection Requirements for Mars Sample Return Missions: Recommendations from a 2009 NRC Report

    NASA Astrophysics Data System (ADS)

    Race, Margaret; Farmer, Jack

    A 2009 report by the National Research Council (NRC) reviewed a previous study on Mars Sample Return (1997) and provided updated recommendations for future sample return mis-sions based on our current understanding about Mars and its biological potential, as well as advances in technology and analytical capabilities. The committee* made 12 specific recommen-dations that fall into three general categories—one related to current scientific understanding, ten based on changes in the technical and/or policy environment, and one aimed at public com-munication. Substantive changes from the 1997 report relate mainly to protocols and methods, technology and infrastructure, and general oversight. This presentation provides an overview of the 2009 report and its recommendations and analyzes how they may impact mission designs and plans. The full report, Assessment of Planetary Protection Requirements for Mars Sample Return Missions is available online at: http://www.nap.edu/catalog.php?recordi d = 12576 * Study participants: Jack D. Farmer, Arizona State University (chair) James F. Bell III, Cornell University Kathleen C. Benison, Central Michigan University William V. Boynton, University of Arizona Sherry L. Cady, Portland State University F. Grant Ferris, University of Toronto Duncan MacPherson, Jet Propulsion Laboratory Margaret S. Race, SETI Institute Mark H. Thiemens, University of California, San Diego Meenakshi Wadhwa, Arizona State University

  2. Chemically-related Groups of Active Ingredients

    EPA Pesticide Factsheets

    Many pesticide active ingredients affect pests in similar ways, and we re-evaluate them together as a group. Groups include carbamate insecticides, neonicotinoids, organochlorines, organophosphates, pyrethrins, and pyrethroids.

  3. Activities: Relating to Graphs in Introductory Algebra.

    ERIC Educational Resources Information Center

    Van Dyke, Frances

    1994-01-01

    Presents activities designed to help students bridge the gap between the graphical representation of a function and a verbal description. Includes a number of nonstandard graphs and reproducible student worksheets. (MKR)

  4. Probing relation between solar activities and seismicity

    NASA Astrophysics Data System (ADS)

    Nikouravan, Bijan; Rawa, J. J.; Sharifi, Rahman; Nikkhah, Mahmoud

    2012-06-01

    In this paper, we studied the relationship between sunspots numbers (SNs), solar 10.7 cm radio flux(SRF), solar irradiance (SI), solar proton events (SPEs) and local earthquakes. The location of the study is selected in Iran area and all earthquakes data chosen for 4 from 1970 to 2010. The study reveals the following conclusions: (i) The total number of local earthquakes in maximum years of solar activities is greater than the minimum years of solar activities from 1964 to 2010, (ii) The total local earthquakes frequency (EF) in the maximum period of solar activities is very close to the maximum annual means of sunspots numbers, (iii) The total local EF in the maximum period of solar activity is very close to the maximum annual means of SPE with negative correlation coefficient, (iv) The local earthquakes in the minimum period of solar activities is very close to the minimum annual means of sunspots numbers with negative correlation and (v) The local earthquake in the minimum period of solar activities is very near to SRF with negative correlation.

  5. A regulator`s perspective on NRC`s participation in the operations & maintenance committees

    SciTech Connect

    Wessman, R.H.

    1996-12-01

    As a regulator fairly new to the American Society of Mechanical Engineers (ASME) Operations and Maintenance (O&M) Committee process, the author does not have a personal historical perspective as do many of the longer-term, and highly respected, members of the O&M Committee. However, as Branch Chief of the Mechanical Engineering Branch, Division of Engineering, in the Office of Nuclear Reactor Regulation at the NRC for just over two years, he has responsibility for the regulatory agency`s review of licensee actions involving the products that come from the efforts of the O&M Committee, as well as responsibility for portions of the activities of interest to other ASME Code groups such as Section III, Section XI, and Qualification of Mechanical Equipment. As a result, the author has learned a great deal about the code process in a short time. Here he gives his perspectives on the process and provides a few thoughts on the direction for the future.

  6. Proteome analysis of Halobacterium sp. NRC-1 facilitated by the biomodule analysis tool BMSorter.

    PubMed

    Gan, Rueichi R; Yi, Eugene C; Chiu, Yulun; Lee, Hookeun; Kao, Yu-Chieh P; Wu, Timothy H; Aebersold, Ruedi; Goodlett, David R; Ng, Wailap Victor

    2006-06-01

    To better understand the extremely halophilic archaeon Halobacterium species NRC-1, we analyzed its soluble proteome by two-dimensional liquid chromatography coupled to electrospray ionization tandem mass spectrometry. A total of 888 unique proteins were identified with a ProteinProphet probability (P) between 0.9 and 1.0. To evaluate the biochemical activities of the organism, the proteomic data were subjected to a biological network analysis using our BMSorter software. This allowed us to examine the proteins expressed in different biomodules and study the interactions between pertinent biomodules. Interestingly an integrated analysis of the enzymes in the amino acid metabolism and citrate cycle networks suggested that up to eight amino acids may be converted to oxaloacetate, fumarate, or oxoglutarate in the citrate cycle for energy production. In addition, glutamate and aspartate may be interconverted from other amino acids or synthesized from citrate cycle intermediates to meet the high demand for the acidic amino acids that are required to build the highly acidic proteome of the organism. Thus this study demonstrated that proteome analysis can provide useful information and help systems analyses of organisms.

  7. Citizenship Related Activities in World History.

    ERIC Educational Resources Information Center

    Poulos, Pete

    1984-01-01

    A world history course is molded around broad instructional goals in which citizenship education can and should be included. Learning activities dealing with ancient Greece illustrate teaching strategies which can be used in high school world history courses to foster citizenship knowledge, skills, and attitudes. (RM)

  8. Understanding the Adaptation of Halobacterium Species NRC-1 to Its Extreme Environment through Computational Analysis of Its Genome Sequence

    PubMed Central

    Kennedy, Sean P.; Ng, Wailap Victor; Salzberg, Steven L.; Hood, Leroy; DasSarma, Shiladitya

    2001-01-01

    The genome of the halophilic archaeon Halobacterium sp. NRC-1 and predicted proteome have been analyzed by computational methods and reveal characteristics relevant to life in an extreme environment distinguished by hypersalinity and high solar radiation: (1) The proteome is highly acidic, with a median pI of 4.9 and mostly lacking basic proteins. This characteristic correlates with high surface negative charge, determined through homology modeling, as the major adaptive mechanism of halophilic proteins to function in nearly saturating salinity. (2) Codon usage displays the expected GC bias in the wobble position and is consistent with a highly acidic proteome. (3) Distinct genomic domains of NRC-1 with bacterial character are apparent by whole proteome BLAST analysis, including two gene clusters coding for a bacterial-type aerobic respiratory chain. This result indicates that the capacity of halophiles for aerobic respiration may have been acquired through lateral gene transfer. (4) Two regions of the large chromosome were found with relatively lower GC composition and overrepresentation of IS elements, similar to the minichromosomes. These IS-element-rich regions of the genome may serve to exchange DNA between the three replicons and promote genome evolution. (5) GC-skew analysis showed evidence for the existence of two replication origins in the large chromosome. This finding and the occurrence of multiple chromosomes indicate a dynamic genome organization with eukaryotic character. PMID:11591641

  9. Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence.

    PubMed

    Kennedy, S P; Ng, W V; Salzberg, S L; Hood, L; DasSarma, S

    2001-10-01

    The genome of the halophilic archaeon Halobacterium sp. NRC-1 and predicted proteome have been analyzed by computational methods and reveal characteristics relevant to life in an extreme environment distinguished by hypersalinity and high solar radiation: (1) The proteome is highly acidic, with a median pI of 4.9 and mostly lacking basic proteins. This characteristic correlates with high surface negative charge, determined through homology modeling, as the major adaptive mechanism of halophilic proteins to function in nearly saturating salinity. (2) Codon usage displays the expected GC bias in the wobble position and is consistent with a highly acidic proteome. (3) Distinct genomic domains of NRC-1 with bacterial character are apparent by whole proteome BLAST analysis, including two gene clusters coding for a bacterial-type aerobic respiratory chain. This result indicates that the capacity of halophiles for aerobic respiration may have been acquired through lateral gene transfer. (4) Two regions of the large chromosome were found with relatively lower GC composition and overrepresentation of IS elements, similar to the minichromosomes. These IS-element-rich regions of the genome may serve to exchange DNA between the three replicons and promote genome evolution. (5) GC-skew analysis showed evidence for the existence of two replication origins in the large chromosome. This finding and the occurrence of multiple chromosomes indicate a dynamic genome organization with eukaryotic character.

  10. Halobacterium salinarum NRC-1 PeptideAtlas: toward strategies for targeted proteomics and improved proteome coverage.

    PubMed

    Van, Phu T; Schmid, Amy K; King, Nichole L; Kaur, Amardeep; Pan, Min; Whitehead, Kenia; Koide, Tie; Facciotti, Marc T; Goo, Young Ah; Deutsch, Eric W; Reiss, David J; Mallick, Parag; Baliga, Nitin S

    2008-09-01

    The relatively small numbers of proteins and fewer possible post-translational modifications in microbes provide a unique opportunity to comprehensively characterize their dynamic proteomes. We have constructed a PeptideAtlas (PA) covering 62.7% of the predicted proteome of the extremely halophilic archaeon Halobacterium salinarum NRC-1 by compiling approximately 636 000 tandem mass spectra from 497 mass spectrometry runs in 88 experiments. Analysis of the PA with respect to biophysical properties of constituent peptides, functional properties of parent proteins of detected peptides, and performance of different mass spectrometry approaches has highlighted plausible strategies for improving proteome coverage and selecting signature peptides for targeted proteomics. Notably, discovery of a significant correlation between absolute abundances of mRNAs and proteins has helped identify low abundance of proteins as the major limitation in peptide detection. Furthermore, we have discovered that iTRAQ labeling for quantitative proteomic analysis introduces a significant bias in peptide detection by mass spectrometry. Therefore, despite identifying at least one proteotypic peptide for almost all proteins in the PA, a context-dependent selection of proteotypic peptides appears to be the most effective approach for targeted proteomics.

  11. Halobacterium salinarum NRC-1 PeptideAtlas: strategies for targeted proteomics

    PubMed Central

    Van, Phu T.; Schmid, Amy K.; King, Nichole L.; Kaur, Amardeep; Pan, Min; Whitehead, Kenia; Koide, Tie; Facciotti, Marc T.; Goo, Young-Ah; Deutsch, Eric W.; Reiss, David J.; Mallick, Parag; Baliga, Nitin S.

    2009-01-01

    The relatively small numbers of proteins and fewer possible posttranslational modifications in microbes provides a unique opportunity to comprehensively characterize their dynamic proteomes. We have constructed a Peptide Atlas (PA) for 62.7% of the predicted proteome of the extremely halophilic archaeon Halobacterium salinarum NRC-1 by compiling approximately 636,000 tandem mass spectra from 497 mass spectrometry runs in 88 experiments. Analysis of the PA with respect to biophysical properties of constituent peptides, functional properties of parent proteins of detected peptides, and performance of different mass spectrometry approaches has helped highlight plausible strategies for improving proteome coverage and selecting signature peptides for targeted proteomics. Notably, discovery of a significant correlation between absolute abundances of mRNAs and proteins has helped identify low abundance of proteins as the major limitation in peptide detection. Furthermore we have discovered that iTRAQ labeling for quantitative proteomic analysis introduces a significant bias in peptide detection by mass spectrometry. Therefore, despite identifying at least one proteotypic peptide for almost all proteins in the PA, a context-dependent selection of proteotypic peptides appears to be the most effective approach for targeted proteomics. PMID:18652504

  12. Union of Science and Societal Objectives: Why Did CLARREO Resonate with NRC Decadal Survey Priorities?

    NASA Astrophysics Data System (ADS)

    Anderson, J. G.; Dykema, J. A.; Gero, J.; Leroy, S. S.; Revercomb, H. E.; Tobin, D. C.; Best, F. A.

    2008-12-01

    The NRC Decadal Survey prioritization process for the Earth sciences involved eight criteria: (1) Contribution to the most important scientific questions facing Earth sciences today (scientific merit, discovery, exploration). (2) Contribution to applications and policy making (societal benefits). (3) Contribution to long-term observational record of the Earth. (4) Ability to complement other observational systems, including national and international plans. (5) Affordability (cost considerations, either total costs for mission or costs per year). (6) Degree of readiness (technical, resources, people). (7) Risk mitigation and strategic redundancy (backup of other critical systems). (8) Significant contribution to more than one thematic application or scientific discipline. CLARREO addresses key societal objectives closely related to key scientific questions that include: (1) the essential responsibility to present and future generations to put in place a benchmark climate record that is global, accurate in perpetuity, tested against independent strategies that reveal systematic errors, and pinned to international standards; (2) the development of an operational climate forecast that is tested and trusted through a disciplined strategy using state-of-the-art observations with mathematically rigorous techniques to systematically improve those forecasts to establish credibility. The means by which these objectives are addressed by CLARREO are presented.

  13. High-pressure tolerance in Halobacterium salinarum NRC-1 and other non-piezophilic prokaryotes.

    PubMed

    Kish, Adrienne; Griffin, Patrick L; Rogers, Karyn L; Fogel, Marilyn L; Hemley, Russell J; Steele, Andrew

    2012-03-01

    In this study, we examined the high-pressure survival of a range of prokaryotes not found in high-pressure environments to determine the effects of adaptations to osmotic and oxidative stresses on piezo-resistance. The pressure survivals of Halobacterium salinarum NRC-1, Deinococcus radiodurans R1, and Chromohalobacter salexigens were compared to that of Escherichia coli MG1655. C. salexigens, which uses the compatible solute ectoine as an osmolyte, was as piezo-sensitive as E. coli MG1655, suggesting that ectoine is not a piezolyte. D. radiodurans R1 and H. salinarum NRC-1, both resistant to oxidative stress, were found to be highly piezo-resistant. H. salinarum NRC-1 showed nearly full survival after pressurization up to 400 MPa; a survival 3.5 log units higher than E. coli MG1655. This piezo-resistance was maintained in H. salinarum NRC-1 for pressurizations up to 1 h. We hypothesize that the high-pressure resistance of H. salinarum NRC-1 is due to a combination of factors including cell envelope structure and the presence of intracellular salts.

  14. nRC: non-coding RNA Classifier based on structural features.

    PubMed

    Fiannaca, Antonino; La Rosa, Massimo; La Paglia, Laura; Rizzo, Riccardo; Urso, Alfonso

    2017-01-01

    Non-coding RNA (ncRNA) are small non-coding sequences involved in gene expression regulation of many biological processes and diseases. The recent discovery of a large set of different ncRNAs with biologically relevant roles has opened the way to develop methods able to discriminate between the different ncRNA classes. Moreover, the lack of knowledge about the complete mechanisms in regulative processes, together with the development of high-throughput technologies, has required the help of bioinformatics tools in addressing biologists and clinicians with a deeper comprehension of the functional roles of ncRNAs. In this work, we introduce a new ncRNA classification tool, nRC (non-coding RNA Classifier). Our approach is based on features extraction from the ncRNA secondary structure together with a supervised classification algorithm implementing a deep learning architecture based on convolutional neural networks. We tested our approach for the classification of 13 different ncRNA classes. We obtained classification scores, using the most common statistical measures. In particular, we reach an accuracy and sensitivity score of about 74%. The proposed method outperforms other similar classification methods based on secondary structure features and machine learning algorithms, including the RNAcon tool that, to date, is the reference classifier. nRC tool is freely available as a docker image at https://hub.docker.com/r/tblab/nrc/. The source code of nRC tool is also available at https://github.com/IcarPA-TBlab/nrc.

  15. Evaluation of the 1996 NRC beef model under western Canadian environmental conditions.

    PubMed

    Block, H C; McKinnon, J J; Mustafa, A F; Christensen, D A

    2001-01-01

    Two feedlot trials were conducted to evaluate the 1996 NRC beef model under western Canadian conditions. In the first trial, 144 Charolais- (304.6 +/- 16.3 kg) and 144 Hereford- (295.1 +/- 20.8 kg) cross steers were used, whereas the second trial used 88 Angus- (289.7 +/- 15.0 kg), 88 Charolais- (299.8 +/- 17.9 kg), and 88 Hereford- (291.1 +/- 20.9 kg) cross steers. Diets were based on barley silage, rolled barley grain, canola meal, and cereal straw and were analyzed according to the 1996 NRC methodologies. Animal performance and environmental data were collected for 24 pens of steers per trial for the backgrounding and finishing periods. Levels 1 and 2 of the 1996 NRC model were used to generate predictions of DMI and ADG for each pen. Results showed that actual finishing DMI was accurately predicted for Trial 1 and for the combined trials but not for Trial 2. Predicted ADG was lower (P < 0.05) than actual ADG for all feeding periods except Level 1 of the Trial 1 finishing period. All ADG residuals were significant (P < 0.05), indicating inaccurate prediction of ADG in all feeding periods. The 1996 NRC model consistently predicted that protein was not limiting gain. Further investigations and model refinement regarding animal energy requirements under cold weather conditions and effects of limit feeding are required to increase the accuracy of the 1996 NRC model in predicting animal performance.

  16. Group Learning as Relational Economic Activity

    ERIC Educational Resources Information Center

    Saito, Eisuke; Atencio, Matthew

    2014-01-01

    The purpose of this paper is to discuss group learning in line with economic perspectives of embeddedness and integration emanating from the work of Karl Polanyi. Polanyi's work defines economy as a necessary interaction among human beings for survival; the economy is considered inextricably linked from broader society and social relations rather…

  17. Group Learning as Relational Economic Activity

    ERIC Educational Resources Information Center

    Saito, Eisuke; Atencio, Matthew

    2014-01-01

    The purpose of this paper is to discuss group learning in line with economic perspectives of embeddedness and integration emanating from the work of Karl Polanyi. Polanyi's work defines economy as a necessary interaction among human beings for survival; the economy is considered inextricably linked from broader society and social relations rather…

  18. Geopolymers and Related Alkali-Activated Materials

    NASA Astrophysics Data System (ADS)

    Provis, John L.; Bernal, Susan A.

    2014-07-01

    The development of new, sustainable, low-CO2 construction materials is essential if the global construction industry is to reduce the environmental footprint of its activities, which is incurred particularly through the production of Portland cement. One type of non-Portland cement that is attracting particular attention is based on alkali-aluminosilicate chemistry, including the class of binders that have become known as geopolymers. These materials offer technical properties comparable to those of Portland cement, but with a much lower CO2 footprint and with the potential for performance advantages over traditional cements in certain niche applications. This review discusses the synthesis of alkali-activated binders from blast furnace slag, calcined clay (metakaolin), and fly ash, including analysis of the chemical reaction mechanisms and binder phase assemblages that control the early-age and hardened properties of these materials, in particular initial setting and long-term durability. Perspectives for future research developments are also explored.

  19. SU-F-19A-02: Comparison of Absorbed Dose to Water Standards for HDR Ir-192 Brachytherapy Between the LCR, Brazil and NRC, Canada

    SciTech Connect

    Salata, C; David, M; Almeida, C de; El Gamal, I; Cojocaru, C; Mainegra-Hing, E; McEwen, M

    2014-06-15

    Purpose: To compare absorbed dose to water standards for HDR brachytherapy dosimetry developed by the Radiological Science Laboratory of Rio de Janeiro State University (LCR) and the National Research Council, Canada (NRC). Methods: The two institutions have separately developed absorbed dose standards based on the Fricke dosimetry system. There are important differences between the two standards, including: preparation and read-out of the Fricke solution, irradiation geometry of the Fricke holder in relation to the Ir-192 source, and determination of the G-value to be used at Ir-192 energies. All measurements for both standards were made directly at the NRC laboratory (i.e., no transfer instrument was used) using a single Ir-192 source (microSelectron v2). In addition, the NRC group has established a self-consistent method to determine the G-value for Ir-192, based on an interpolation between G-values obtained at Co-60 and 250kVp X-rays, and this measurement was repeated using the LCR Fricke solution to investigate possible systematic uncertainties. Results: G-values for Co-60 and 250 kVp x-rays, obtained using the LCR Fricke system, agreed with the NRC values within 0.5 % and 1 % respectively, indicating that the general assumption of universal G-values is appropriate in this case. The standard uncertainty in the determination of G for Ir-192 is estimated to be 0.6 %. For the comparison of absorbed dose measurements at the reference point for Ir-192 (1 cm depth in water, perpendicular to the seed long-axis), the ratio Dw(NRC)/Dw(LCR) was found to be 1.011 with a combined standard uncertainty of 1.7 %, k=1. Conclusion: The agreement in the absorbed dose to water values for the LCR and NRC systems is very encouraging. Combined with the lower uncertainty in this approach compared to the present air-kerma approach, these results reaffirm the use of Fricke solution as a potential primary standard for HDR Ir-192 brachytherapy.

  20. The use of NPAR (Nuclear Plant Aging Research) results in plant inspection activities

    SciTech Connect

    Gunther, W.; Taylor, J.

    1989-01-01

    The US NRC's Nuclear Plant Aging Research (NPAR) Program is a hardware oriented research program which has produced a large data base of equipment and system operating, maintenance, and testing information. Equipment and systems which have a propensity for age related degradation are identified, and methods for detecting and mitigating aging effects have been evaluated. As plants age, it becomes increasingly important that NRC inspectors be cognizant of plant aging phenomena. This paper describes the NPAR information which can enhance inspection activities, and provides a mechanism for making pertinent research available to the inspectors. 7 refs., 2 figs.

  1. Preparation for Scaling Studies of Ice-Crystal Icing at the NRC Research Altitude Test Facility

    NASA Technical Reports Server (NTRS)

    Struk, Peter M.; Bencic, Timothy J.; Tsao, Jen-Ching; Fuleki, Dan; Knezevici, Daniel C.

    2013-01-01

    This paper describes experiments conducted at the National Research Council (NRC) of Canadas Research Altitiude Test Facility between March 26 and April 11, 2012. The tests, conducted collaboratively between NASA and NRC, focus on three key aspects in preparation for later scaling work to be conducted with a NACA 0012 airfoil model in the NRC Cascade rig: (1) cloud characterization, (2) scaling model development, and (3) ice-shape profile measurements. Regarding cloud characterization, the experiments focus on particle spectra measurements using two shadowgraphy methods, cloud uniformity via particle scattering from a laser sheet, and characterization of the SEA Multi-Element probe. Overviews of each aspect as well as detailed information on the diagnostic method are presented. Select results from the measurements and interpretation are presented which will help guide future work.

  2. Regulatory multidimensionality of gas vesicle biogenesis in Halobacterium salinarum NRC-1.

    PubMed

    Yao, Andrew I; Facciotti, Marc T

    2011-01-01

    It is becoming clear that the regulation of gas vesicle biogenesis in Halobacterium salinarum NRC-1 is multifaceted and appears to integrate environmental and metabolic cues at both the transcriptional and posttranscriptional levels. The mechanistic details underlying this process, however, remain unclear. In this manuscript, we quantify the contribution of light scattering made by both intracellular and released gas vesicles isolated from Halobacterium salinarum NRC-1, demonstrating that each form can lead to distinct features in growth curves determined by optical density measured at 600 nm (OD(600)). In the course of the study, we also demonstrate the sensitivity of gas vesicle accumulation in Halobacterium salinarum NRC-1 on small differences in growth conditions and reevaluate published works in the context of our results to present a hypothesis regarding the roles of the general transcription factor tbpD and the TCA cycle enzyme aconitase on the regulation of gas vesicle biogenesis.

  3. Regulatory Multidimensionality of Gas Vesicle Biogenesis in Halobacterium salinarum NRC-1

    PubMed Central

    Yao, Andrew I.; Facciotti, Marc T.

    2011-01-01

    It is becoming clear that the regulation of gas vesicle biogenesis in Halobacterium salinarum NRC-1 is multifaceted and appears to integrate environmental and metabolic cues at both the transcriptional and posttranscriptional levels. The mechanistic details underlying this process, however, remain unclear. In this manuscript, we quantify the contribution of light scattering made by both intracellular and released gas vesicles isolated from Halobacterium salinarum NRC-1, demonstrating that each form can lead to distinct features in growth curves determined by optical density measured at 600 nm (OD600). In the course of the study, we also demonstrate the sensitivity of gas vesicle accumulation in Halobacterium salinarum NRC-1 on small differences in growth conditions and reevaluate published works in the context of our results to present a hypothesis regarding the roles of the general transcription factor tbpD and the TCA cycle enzyme aconitase on the regulation of gas vesicle biogenesis. PMID:22110395

  4. Environmental properties related to active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Manzer, Lianne H.

    There continues to be significant controversy regarding the mechanisms responsible for the initiation of activity in galactic nuclei. It is well understood that the non-thermal energy produced by an AGN is due to accretion onto a supermassive black hole. It has not yet been determined, however, what leads particular galaxies to become active. An accurate exploration into what triggers an AGN demands an analysis of a large sample of galaxies across a diverse set of environments. In this work, we investigate possible environmental influences by carrying out a statistical investigation of galaxy groups. Using the catalogue of Yang et al. (2007), in which groups of galaxies containing between 2 and 20 members with redshifts between 0.01 -- 0.20 were taken from the Sloan Digital Sky Survey, we investigate the fraction of active galactic nuclei (AGN) within these groups and compare it to the sample of isolated galaxies also obtained from Yang et al. (2007). After correcting our spectroscopic data for extinction and underlying stellar absorption, we classify the galaxy sample using relevant emission-line ratios. We propose an alternate method for classifying emission-line galaxies, including AGN, which builds upon standard diagnostic utilities used for optical classification and includes uncertainties. Such classification probabilities offer a more robust and consistent method of investigating the effect of group environments with galaxy type. We find our sample to be a fair representation of the local universe by comparing the luminosity function of our entire data set to that of Blanton et al. (2001), Blanton et al. (2003b), and Montero-Dorta & Prada (2009). The evidence also suggests that the luminosity function of galaxies differs between isolated galaxies and galaxies in groups. We find a significant increase in the fraction of AGNs identified in grouped environments. On the other hand, we find a higher fraction of starforming galaxies within isolated systems. We

  5. The Afrocentric Paradigm in Health-Related Physical Activity.

    ERIC Educational Resources Information Center

    Pittman, Beverly D.

    2003-01-01

    Examines the potential role of culture in health-related physical activity participation, discussing kinesiology and reporting results from a health-related physical activity study of women, some of whom had taken a culturally designed aerobics class. Participants demonstrated the positive impact of culture on physical activity participation.…

  6. Lunar Dust Activation and Related Studies

    NASA Technical Reports Server (NTRS)

    Jeevarajan, Antony; Bradley, Robert; Hurley, Elizabeth; Hammond, Dianne

    2006-01-01

    The primary objective of the presentation is to identify a set of experiments to activate the lunar dust and monitor the mode of deactivation process using various analytical methods. To satisfy the objective, a large set of experiments will be carried out using lunar dust stimulant (JSC-1a-vf obtained from Dr. V. Carter from University of Texas at Dallas) to optimize the methodology. After refining the methodology to carry out the experiments using the simulant, real lunar dust will be used to obtain the necessary results. The secondary objective of the presentation is to identify a set of experiments to assess the potential toxicity of the dust using cellular systems. One of the cell lines that we identified is WI-38 human lung cell line.

  7. 75 FR 39585 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY.... Nuclear Regulatory Commission (NRC). ACTION: Notice of pending NRC action to submit an information... and timely reports of radiation exposure be made to individuals involved in NRC-licensed activities. 4...

  8. Bird activity levels related to weather

    USGS Publications Warehouse

    Robbins, C.S.; Ralph, C. John; Scott, J. Michael

    1981-01-01

    The Breeding Bird Survey data bank serves as a primary source for studying effects of sky cover, wind speed, and temperature on bird census results. Other standardized methods, such as spot-mapping (Breeding Bird Census), point counts, banding, and the Winter Bird Survey, provide additional, but limited, means of assessing effects of weather. Numbers of songbirds detected are generally inversely correlated with wind speed, but hawks often are seen in larger numbers on windy days. Rain greatly reduces the numbers of birds detected. Cloud cover has relatively little influence on early morning bird counts during the peak of the breeding season. Fog selectively favors auditory detections of some species. Counts of many species are correlated with temperature, but effects are minor unless temperatures are extreme. Under marginal weather conditions, total species observed may be nearly normal, whereas number of individuals observed is reduced, as is the opportunity to record simultaneous registrations

  9. General statement of policy and procedures for NRC enforcement actions: Enforcement policy. Revision 1

    SciTech Connect

    1998-05-01

    This document includes the US Nuclear Regulatory Commission`s (NRC`s or Commission`s) revised General Statement of Policy and Procedure for Enforcement Actions (Enforcement Policy) as it was published in the Federal Register on May 13, 1998 (63 ER 26630). The Enforcement Policy is a general statement of policy explaining the NRC`s policies and procedures in initiating enforcement actions, and of the presiding officers and the Commission in reviewing these actions. This policy statement is applicable to enforcement matters involving the radiological health and safety of the public, including employees` health and safety, the common defense and security, and the environment.

  10. NRC review of passive reactor design certification testing programs: Overview, progress, and regulatory perspective

    SciTech Connect

    Levin, A.E.

    1995-09-01

    New reactor designs, employing passive safety systems, are currently under development by reactor vendors for certification under the U.S. Nuclear Regulatory Commission`s (NRC`s) design certification rule. The vendors have established testing programs to support the certification of the passive designs, to meet regulatory requirements for demonstration of passive safety system performance. The NRC has, therefore, developed a process for the review of the vendors` testing programs and for incorporation of the results of those reviews into the safety evaluations for the passive plants. This paper discusses progress in the test program reviews, and also addresses unique regulatory aspects of those reviews.

  11. Geomechanical Simulations Related to UCG Activities

    SciTech Connect

    Vorobiev, O; Morris, J; Antoun, T; Friedmann, S J

    2008-07-11

    This paper presents results from a recent investigation into a range of geomechanical processes induced by UCG activities. The mechanical response of the coal and host rock mass plays a role in every stage of UCG operations. For example, cavity collapse during the burn has significant effect upon the rate of the burn itself. In the vicinity of the cavity, collapse and fracturing may result in enhanced hydraulic conductivity of the rock matrix above the burn chamber. Even far from the cavity, stresses due to subsidence may be sufficient to induce new fractures linking previously isolated aquifers. These mechanical processes are very important in understanding the risk of unacceptable subsidence and the potential for groundwater contamination. The mechanical processes are inherently non-linear, involving significant inelastic response, especially in the region closest to the cavity. in addition, the response of the rock mass involves both continuum and discrete mechanical behavior. To better understand these effects, they have applied a suite of highly non-linear computational tools in both two and three dimensions to a series of UCG scenarios. The calculations include combinations of continuum and discrete mechanical responses by employing fully coupled finite element and discrete element capabilities.

  12. NASA's UAS [Unmanned Aircraft Systems] Related Activities

    NASA Technical Reports Server (NTRS)

    Bauer, Jeffrey

    2012-01-01

    NASA continues to operate all sizes of UAS in all classes of airspace both domestically and internationally. Missions range from highly complex operations in coordination with piloted aircraft, ground, and space systems in support of science objectives to single aircraft operations in support of aeronautics research. One such example is a scaled commercial transport aircraft being used to study recovery techniques due to large upsets. NASA's efforts to support routine UAS operations continued on several fronts last year. At the national level in the United States (U.S.), NASA continued its support of the UAS Executive Committee (ExCom) comprised of the Federal Aviation Administration (FAA), Department of Defense (DoD), Department of Homeland Security (DHS), and NASA. The committee was formed in recognition of the need of UAS operated by these agencies to access to the National Airspace System (NAS) to support operational, training, development and research requirements. Recommendations were received on how to operate both manned and unmanned aircraft in class D airspace and plans are being developed to validate and implement those recommendations. In addition the UAS ExCom has begun developing recommendations for how to achieve routine operations in remote areas as well as for small UAS operations in class G airspace. As well as supporting the UAS ExCom, NASA is a participant in the recently formed Aviation Rule Making Committee for UAS. This committee, established by the FAA, is intended to propose regulatory guidance which would enable routine civil UAS operations. As that effort matures NASA stands ready to supply the necessary technical expertise to help that committee achieve its objectives. By supporting both the UAS ExCom and UAS ARC, NASA is positioned to provide its technical expertise across the full spectrum of UAS airspace access related topic areas. The UAS NAS Access Project got underway this past year under the leadership of NASA s Aeronautics

  13. An assessment of the contribution of NRC (Nuclear Regulatory Commission) regulatory growth to nuclear plant cost growth using engineering scope changes

    SciTech Connect

    Cohen, S.

    1987-03-01

    The purpose of this study is to determine the contribution of NRC regulations to the growth in nuclear power plant capital costs using the case study method. The two plants selected for the case studies are Florida Power and Light Company's (FP and L) St. Lucie Unit 1 (SL1) and St. Lucie Unit 2 (SL2). SL1 was constructed in the early 1970s and was granted an operating license in 1976. SL2 was constructed in the late 1970s and early 1980s, and was granted an operating license in 1983. The information bases were the amendments to the contracts between FP and L and its architect-engineer/constructor, i.e., the ''scope changes''. These were examined and analyzed for causation, i.e., NRC-initiated or utility-initiated, and all of the costs associated with scope changes of each type were aggregated to determine the contribution of each. Although the scope changes accounted for only a small fraction of the total cost growth for either plant, they were still used to determine the relative contribution of regulatory growth to cost growth. Unexpectedly, a significantly higher percentage of out-of-scope work (approximately 84%) was attributable to NRC regulatory requirements for SL1 than SL2 (approximately 47%). These results were unexpected because SL2 was constructed during a period in which regulation was considered to be particularly unstable. However, a more detailed analysis of causation indicates that a shift occurred from an ad-hoc mode of regulation in the early 1970s to a more prescriptive process in the late 1970s. Thus the number of formal NRC requirements may not be a valid measure of regulatory stability.

  14. Answers to frequently asked questions about cleanup activities at Three Mile Island, Unit 2. Public information report

    SciTech Connect

    Not Available

    1980-09-01

    The document presents answers to frequently asked questions about plans for cleanup and decontamination activities at Three Mile Island, Unit 2. Answers to the questions asked are based on information in the NRC 'Draft Programmatic Environmental Impact Statement related to decontamination and disposal of radioactive wastes resulting from March 28, 1979, accident, Three Mile Island Nuclear Station, Unit 2,' NUREG-0683.

  15. The role of public relations activities in hospital choice.

    PubMed

    Tengilimoglu, Dilaver; Yesiltas, Mehmet; Kisa, Adnan; Dziegielewski, Sophia F

    2007-01-01

    Public relations activities for all organizations can have an important effect on consumer decision-making when buying goods or services. This study examines the effect that public relations activities can have regarding consumer decisions and choice. To explore exemplify this relationship a questionnaire was given to 971 patients within public, university and private hospitals in Ankara, Turkey. Study results show that public relations activities were a crucial factor in determining consumer hospital choice. The majority of respondents reported that the behaviors and attitude of personnel as public relations activities that support the hospital's reputation within the public were the primary variables in hospital choice. Health care managers can use these findings to further understand how patients make informed choices related to usage of a health care facility and to develop and/or improve public relations activities.

  16. 10 CFR Appendix N to Part 110 - Illustrative List of Lithium Isotope Separation Facilities, Plants and Equipment Under NRC's...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., Plants and Equipment Under NRC's Export Licensing Authority N Appendix N to Part 110 Energy NUCLEAR... Appendix N to Part 110—Illustrative List of Lithium Isotope Separation Facilities, Plants and Equipment Under NRC's Export Licensing Authority a. Facilities or plants for the separation of lithium isotopes....

  17. 10 CFR Appendix N to Part 110 - Illustrative List of Lithium Isotope Separation Facilities, Plants and Equipment Under NRC's...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., Plants and Equipment Under NRC's Export Licensing Authority N Appendix N to Part 110 Energy NUCLEAR... Appendix N to Part 110—Illustrative List of Lithium Isotope Separation Facilities, Plants and Equipment Under NRC's Export Licensing Authority a. Facilities or plants for the separation of lithium isotopes....

  18. 10 CFR Appendix N to Part 110 - Illustrative List of Lithium Isotope Separation Facilities, Plants and Equipment Under NRC's...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., Plants and Equipment Under NRC's Export Licensing Authority N Appendix N to Part 110 Energy NUCLEAR... Appendix N to Part 110—Illustrative List of Lithium Isotope Separation Facilities, Plants and Equipment Under NRC's Export Licensing Authority a. Facilities or plants for the separation of lithium isotopes....

  19. Final report of the NRC-Agreement State Working Group to evaluate control and accountability of licensed devices

    SciTech Connect

    1996-10-01

    US NRC staff acknowledged that licensees were having problems maintaining control over and accountability for devices containing radioactive material. In June 1995, NRC approved the staff`s suggestion to form a joint NRC-Agreement State Working Group to evaluate the problem and propose solutions. The staff indicated that the Working Group was necessary to address the concerns from a national perspective, allow for a broad level of Agreement State input, and to reflect their experience. Agreement State participation in the process was essential since some Agreement States have implemented effective programs for oversight of device users. This report includes the 5 recommendations proposed by the Working Group to increase regulatory oversight, increase control and accountability of devices, ensure proper disposal, and ensure disposal of orphaned devices. Specifically, the Working Group recommends that: (1) NRC and Agreement States increase regulatory oversight for users of certain devices; (2) NRC and Agreement State impose penalties on persons losing devices; (3) NRC and Agreement States ensure proper disposal of orphaned devices; (4) NRC encourage States to implement similar oversight programs for users of Naturally-Occurring or Accelerator- Produced Material; and (5) NRC encourage non-licensed stakeholders to take appropriate actions, such as instituting programs for material identification.

  20. Superfund Policy Statements and Guidance Regarding Disposition of Radioactive Waste in Non-NRC Licensed Disposal Facilities - 13407

    SciTech Connect

    Walker, Stuart

    2013-07-01

    This talk will discuss EPA congressional testimony and follow-up letters, as well as letters to other stakeholders on EPA's perspectives on the disposition of radioactive waste outside of the NRC licensed disposal facility system. This will also look at Superfund's historical practices, and emerging trends in the NRC and agreement states on waste disposition. (author)

  1. 10 CFR Appendix A to Part 110 - Illustrative List of Nuclear Reactor Equipment Under NRC Export Licensing Authority

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Illustrative List of Nuclear Reactor Equipment Under NRC... List of Nuclear Reactor Equipment Under NRC Export Licensing Authority Note: A nuclear reactor... core of a nuclear reactor and capable of withstanding the operating pressure of the primary coolant....

  2. 10 CFR Appendix A to Part 110 - Illustrative List of Nuclear Reactor Equipment Under NRC Export Licensing Authority

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Illustrative List of Nuclear Reactor Equipment Under NRC... List of Nuclear Reactor Equipment Under NRC Export Licensing Authority Note—A nuclear reactor basically... nuclear reactor and capable of withstanding the operating pressure of the primary coolant. (2) On-line...

  3. 10 CFR Appendix A to Part 110 - Illustrative List of Nuclear Reactor Equipment Under NRC Export Licensing Authority

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Illustrative List of Nuclear Reactor Equipment Under NRC... List of Nuclear Reactor Equipment Under NRC Export Licensing Authority Note—A nuclear reactor basically... nuclear reactor and capable of withstanding the operating pressure of the primary coolant. (2) On-line...

  4. 10 CFR Appendix A to Part 110 - Illustrative List of Nuclear Reactor Equipment Under NRC Export Licensing Authority

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Illustrative List of Nuclear Reactor Equipment Under NRC... List of Nuclear Reactor Equipment Under NRC Export Licensing Authority Note—A nuclear reactor basically... nuclear reactor and capable of withstanding the operating pressure of the primary coolant. (2) On-line...

  5. 10 CFR Appendix A to Part 110 - Illustrative List of Nuclear Reactor Equipment Under NRC Export Licensing Authority

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Illustrative List of Nuclear Reactor Equipment Under NRC... List of Nuclear Reactor Equipment Under NRC Export Licensing Authority Note—A nuclear reactor basically... nuclear reactor and capable of withstanding the operating pressure of the primary coolant. (2) On-line...

  6. 10 CFR 110.9a - List of nuclear equipment and material under NRC import licensing authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false List of nuclear equipment and material under NRC import licensing authority. 110.9a Section 110.9a Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.9a List of nuclear equipment and material under NRC import licensing authority. (a...

  7. 10 CFR 110.9a - List of nuclear equipment and material under NRC import licensing authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false List of nuclear equipment and material under NRC import licensing authority. 110.9a Section 110.9a Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.9a List of nuclear equipment and material under NRC import licensing authority. (a...

  8. 10 CFR 110.9a - List of nuclear equipment and material under NRC import licensing authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false List of nuclear equipment and material under NRC import licensing authority. 110.9a Section 110.9a Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.9a List of nuclear equipment and material under NRC import licensing authority. (a...

  9. 75 FR 21979 - NRC Region II Address and Main Telephone Number Changes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... are effective 30 days after publication in the Federal Register. These amendments do not require... incorporated into the following sections of the NRC's regulations: Sec. 1.5(b)(2), Appendix D to 10 CFR Part 20... has been changed. The new telephone number is incorporated into Appendix D to 10 CFR Part 20 and...

  10. Approaches for Evaluating the NRC Resident Research Associateship Program at NIST

    ERIC Educational Resources Information Center

    Sislin, John, Ed.

    2007-01-01

    The NRC Resident Research Associateship Program at NIST provides two-year temporary appointments for outstanding scientists and engineers. This book describes program applicants and awardees and offers suggestions for an in-depth assessment of career outcomes. Preliminary investigation indicates that outreach efforts produce more qualified…

  11. NRC TLD Direct Radiation Monitoring Network. Progress report, October--December 1996

    SciTech Connect

    Struckmeyer, R.

    1997-03-01

    This report presents the results of the NRC Direct Radiation Monitoring Network for the fourth quarter of 1996. It provides the ambient radiation levels measured in the vicinity of 74 sites throughout the United States. In addition, it describes the equipment used, monitoring station selection criteria, characterization of the dosimeter response, calibration procedures, statistical methods, intercomparison, and quality assurance program. 3 figs., 4 tabs.

  12. NRC TLD Direct Radiation Monitoring Network progress report, October--December 1994. Volume 14, No. 4

    SciTech Connect

    Struckmeyer, R.

    1995-03-01

    This report presents the results of the NRC Direct Radiation Monitoring Network for the fourth quarter of 1994. It provides the ambient radiation levels measured in the vicinity of 75 sites throughout the United States. In addition, it describes the equipment used, monitoring station selection criteria, characterization of the dosimeter response, calibration procedures, statistical methods, intercomparison, and quality assurance program.

  13. The Future of Toxicity Testing - the NRC Vision and EPA’s ToxCast Program

    EPA Science Inventory

    The EPA requested the National Research Council (NRC) to develop a vision and strategic plan for toxicity testing in the 21st century. The 2007 report called for transforming toxicology to provide a robust scientific basis for assessing adverse health effects of environmental age...

  14. 10 CFR 110.8 - List of nuclear facilities and equipment under NRC export licensing authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... under NRC export licensing authority. (a) Nuclear reactors and especially designed or prepared equipment and components for nuclear reactors. (See Appendix A to this part.) (b) Plants for the separation of... plants. (See Appendix N to this part.) (d) Plants for the reprocessing of irradiated nuclear reactor...

  15. 10 CFR 110.8 - List of nuclear facilities and equipment under NRC export licensing authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... under NRC export licensing authority. (a) Nuclear reactors and especially designed or prepared equipment and components for nuclear reactors. (See Appendix A to this part.) (b) Plants for the separation of... plants. (See Appendix N to this part.) (d) Plants for the reprocessing of irradiated nuclear reactor...

  16. 10 CFR 110.8 - List of nuclear facilities and equipment under NRC export licensing authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... under NRC export licensing authority. (a) Nuclear reactors and especially designed or prepared equipment and components for nuclear reactors. (See Appendix A to this part.) (b) Plants for the separation of... plants. (See Appendix N to this part.) (d) Plants for the reprocessing of irradiated nuclear reactor...

  17. 10 CFR 2.1316 - Authority and role of NRC staff.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Authority and role of NRC staff. 2.1316 Section 2.1316 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF... and parties to the proceeding. (b) Except as otherwise directed in accordance with § 2.1309(a)(7),...

  18. 10 CFR 51.104 - NRC proceeding using public hearings; consideration of environmental impact statement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false NRC proceeding using public hearings; consideration of environmental impact statement. 51.104 Section 51.104 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED... Environmental Policy Act-Regulations Implementing Section 102(2) Nepa Procedure and Administrative Action §...

  19. NRC regulatory agenda: Semiannual report, January--June 1995. Volume 14, Number 1

    SciTech Connect

    1995-09-01

    The Regulatory Agenda is a semiannual compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and of all petitions for rulemaking that the NRC has received that are pending disposition. The agenda consists of two sections that have been updated through June 30, 1995. Section 1, ``Rules,`` includes (A) rules on which final action has been taken since December 30, 1994, the closing date of the last NRC Regulatory Agenda; (B) rules published previously as proposed rules on which the Commission has not taken final action; (C) rules published as advance notices of proposed rulemaking for which neither a proposed nor final rule has been issued; and (D) unpublished rules on which the NRC expects to take action. Section 2, ``Petitions for Rulemaking,`` includes (A) petitions denied or incorporated into final rules since December 30, 1994; (B) petitions incorporated into proposed rules; (C) petitions pending staff review, and (D) petitions with deferred action.

  20. Research-Doctorate Programs in the Biomedical Sciences: Selected Findings from the NRC Assessment

    ERIC Educational Resources Information Center

    Lorden, Joan F., Ed.; Kuh, Charlotte V., Ed.; Voytuk, James A., Ed.

    2011-01-01

    "Research Doctorate Programs in the Biomedical Sciences: Selected Findings from the NRC Assessment" examines data on the biomedical sciences programs to gather additional insight about the talent, training environment, outcomes, diversity, and international participation in the biomedical sciences workforce. This report supports an…

  1. Grinding the Antitesting Ax: More Bias than Evidence behind NRC Panel's Conclusions

    ERIC Educational Resources Information Center

    Hanushek, Eric A.

    2012-01-01

    In all the acrimonious discussion surrounding No Child Left Behind Act of 2001 (NCLB), surprisingly little attention has been given to the actual impact of that legislation and other accountability systems on student performance. Now a reputable body, a committee set up by the National Research Council (NRC), the research arm of the National…

  2. 10 CFR 51.104 - NRC proceeding using public hearings; consideration of environmental impact statement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... environmental impact statement. 51.104 Section 51.104 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED....104 NRC proceeding using public hearings; consideration of environmental impact statement. (a)(1) In... subpart until the final environmental impact statement is filed with the Environmental Protection Agency...

  3. 10 CFR 51.104 - NRC proceeding using public hearings; consideration of environmental impact statement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... environmental impact statement. 51.104 Section 51.104 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED....104 NRC proceeding using public hearings; consideration of environmental impact statement. (a)(1) In... subpart until the final environmental impact statement is filed with the Environmental Protection Agency...

  4. 10 CFR 51.104 - NRC proceeding using public hearings; consideration of environmental impact statement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... environmental impact statement. 51.104 Section 51.104 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED....104 NRC proceeding using public hearings; consideration of environmental impact statement. (a)(1) In... subpart until the final environmental impact statement is filed with the Environmental Protection Agency...

  5. 10 CFR 9.201 - Production or disclosure prohibited unless approved by appropriate NRC official.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... or Disclosure in Response to Subpoenas or Demands of Courts or Other Authorities § 9.201 Production..., in response to a demand of a court or other judicial or quasi-judicial authority, produce any... approval of the appropriate NRC official. When the demand is for material contained in the files of...

  6. 10 CFR 52.99 - Inspection during construction; ITAAC schedules and notifications; NRC notices.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Inspection during construction; ITAAC schedules and notifications; NRC notices. 52.99 Section 52.99 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.99 Inspection during construction...

  7. 10 CFR 52.99 - Inspection during construction; ITAAC schedules and notifications; NRC notices.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Inspection during construction; ITAAC schedules and notifications; NRC notices. 52.99 Section 52.99 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.99 Inspection during construction...

  8. The Future of Toxicity Testing - the NRC Vision and EPA’s ToxCast Program

    EPA Science Inventory

    The EPA requested the National Research Council (NRC) to develop a vision and strategic plan for toxicity testing in the 21st century. The 2007 report called for transforming toxicology to provide a robust scientific basis for assessing adverse health effects of environmental age...

  9. Problems and Delays Overshadow NRC's Initial Success in Improving Reactor Operators' Capabilities.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    The nuclear power plant accident at Three Mile Island raised many questions concerning the safety of nuclear power plant operations and the ability of nuclear plant reactor operators to respond to abnormal or accident conditions. In response, the Nuclear Regulatory Commission (NRC) developed a plan, which included short- and long-term actions to…

  10. Problems and Delays Overshadow NRC's Initial Success in Improving Reactor Operators' Capabilities.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    The nuclear power plant accident at Three Mile Island raised many questions concerning the safety of nuclear power plant operations and the ability of nuclear plant reactor operators to respond to abnormal or accident conditions. In response, the Nuclear Regulatory Commission (NRC) developed a plan, which included short- and long-term actions to…

  11. Research-Doctorate Programs in the Biomedical Sciences: Selected Findings from the NRC Assessment

    ERIC Educational Resources Information Center

    Lorden, Joan F., Ed.; Kuh, Charlotte V., Ed.; Voytuk, James A., Ed.

    2011-01-01

    "Research Doctorate Programs in the Biomedical Sciences: Selected Findings from the NRC Assessment" examines data on the biomedical sciences programs to gather additional insight about the talent, training environment, outcomes, diversity, and international participation in the biomedical sciences workforce. This report supports an…

  12. Grinding the Antitesting Ax: More Bias than Evidence behind NRC Panel's Conclusions

    ERIC Educational Resources Information Center

    Hanushek, Eric A.

    2012-01-01

    In all the acrimonious discussion surrounding No Child Left Behind Act of 2001 (NCLB), surprisingly little attention has been given to the actual impact of that legislation and other accountability systems on student performance. Now a reputable body, a committee set up by the National Research Council (NRC), the research arm of the National…

  13. Approaches for Evaluating the NRC Resident Research Associateship Program at NIST

    ERIC Educational Resources Information Center

    Sislin, John, Ed.

    2007-01-01

    The NRC Resident Research Associateship Program at NIST provides two-year temporary appointments for outstanding scientists and engineers. This book describes program applicants and awardees and offers suggestions for an in-depth assessment of career outcomes. Preliminary investigation indicates that outreach efforts produce more qualified…

  14. 12 CFR 225.123 - Activities closely related to banking.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Activities closely related to banking. 225.123 Section 225.123 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.123 Activities closely related to banking. (a) Effective June...

  15. Animal Related Activities as Determinants of Species Knowledge

    ERIC Educational Resources Information Center

    Randler, Christoph

    2010-01-01

    Previous work has established a relationship between knowledge and environmental concern. Different factors may contribute to this knowledge and animal-related leisure activities may also contribute to this knowledge. 390 participants in Leipzig, Germany were interviewed to assess their animal-related leisure activities, their demographic status…

  16. Animal Related Activities as Determinants of Species Knowledge

    ERIC Educational Resources Information Center

    Randler, Christoph

    2010-01-01

    Previous work has established a relationship between knowledge and environmental concern. Different factors may contribute to this knowledge and animal-related leisure activities may also contribute to this knowledge. 390 participants in Leipzig, Germany were interviewed to assess their animal-related leisure activities, their demographic status…

  17. Public Relations and Propaganda: Restrictions on Executive Agency Activities

    DTIC Science & Technology

    2005-03-21

    executive branch agencies’ expenditures of appropriated funds on public relations activities, some of which have been characterized as propagandistic...Congress may ask the Government Accountability Office (GAO) to examine an agency’s expenditures on public relations activities with a view to their...7 Tracking Expenditures

  18. Relation Between Higher Physical Activity and Public Transit Use

    PubMed Central

    Vernez Moudon, Anne; Kang, Bumjoon; Hurvitz, Philip M.; Zhou, Chuan

    2014-01-01

    Objectives. We isolated physical activity attributable to transit use to examine issues of substitution between types of physical activity and potential confounding of transit-related walking with other walking. Methods. Physical activity and transit use data were collected in 2008 to 2009 from 693 Travel Assessment and Community study participants from King County, Washington, equipped with an accelerometer, a portable Global Positioning System, and a 7-day travel log. Physical activity was classified into transit- and non–transit-related walking and nonwalking time. Analyses compared physical activity by type between transit users and nonusers, between less and more frequent transit users, and between transit and nontransit days for transit users. Results. Transit users had more daily overall physical activity and more total walking than did nontransit users but did not differ on either non–transit-related walking or nonwalking physical activity. Most frequent transit users had more walking time than least frequent transit users. Higher physical activity levels for transit users were observed only on transit days, with 14.6 minutes (12.4 minutes when adjusted for demographics) of daily physical activity directly linked with transit use. Conclusions. Because transit use was directly related to higher physical activity, future research should examine whether substantive increases in transit access and use lead to more physical activity and related health improvements. PMID:24625142

  19. Disentangling longitudinal relations between physical activity, work-related fatigue, and task demands.

    PubMed

    de Vries, Juriena D; Claessens, Brigitte J C; van Hooff, Madelon L M; Geurts, Sabine A E; van den Bossche, Seth N J; Kompier, Michiel A J

    2016-01-01

    This longitudinal study examined 'normal', 'reversed', and 'reciprocal' relationships between (1) physical activity and work-related fatigue; and (2) physical activity and task demands. Furthermore, the effects of across-time change in meaningful physical activity groups on levels of employees' work-related fatigue and task demands were studied. These groups were based on employees' compliance with the international physical activity norm. Two waves with a one-year time lag of a national representative survey on the quality of work, health, and well-being among Dutch employees were used (N = 2275). Longitudinal effects were tested using Structural Equation Modelling. Meaningful physical activity groups were compared using group-by-time analysis of covariance. Support was found for reciprocal relations between physical activity and work-related fatigue. It was found that an increase in physical activity is associated with a decrease in work-related fatigue over time and that an increase in work-related fatigue is associated with a decrease in physical activity over time. No significant longitudinal relations were found between physical activity and task demands. Employees whose compliance with the physical activity norm changed over time showed fairly stable levels of work-related fatigue and task demands. The current findings provide evidence for the potential role of physical activity in the prevention and reduction in work-related fatigue. However, results also indicate that fatigued workers, who would benefit most from physical activity, are less physically active. Our results further indicate that relying on changes in compliance to the physical activity norm may not be the most suitable way to examine changes in work-related fatigue.

  20. Summary of high burnup fuel issues and NRC`s plan of action

    SciTech Connect

    Meyer, R.O.

    1997-01-01

    For the past two years the Office of Nuclear Regulatory Research has concentrated mostly on the so-called reactivity-initiated accidents -- the RIAs -- in this session of the Water Reactor Safety Information Meeting, but this year there is a more varied agenda. RIAs are, of course, not the only events of interest for reactor safety that are affected by extended burnup operation. Their has now been enough time to consider a range of technical issues that arise at high burnup, and a list of such issues being addressed in their research program is given here. (1) High burnup capability of the steady-state code (FRAPCON) used for licensing audit calculations. (2) General capability (including high burnup) of the transient code (FRAPTRAN) used for special studies. (3) Adequacy at high burnup of fuel damage criteria used in regulation for reactivity accidents. (4) Adequacy at high burnup of models and fuel related criteria used in regulation for loss-of-coolant accidents (LOCAs). (5) Effect of high burnup on fuel system damage during normal operation, including control rod insertion problems. A distinction is made between technical issues, which may or may not have direct licensing impacts, and licensing issues. The RIAs became a licensing issue when the French test in CABRI showed that cladding failures could occur at fuel enthalpies much lower than a value currently used in licensing. Fuel assembly distortion became a licensing issue when control rod insertion was affected in some operating plants. In this presentation, these technical issues will be described and the NRC`s plan of action to address them will be discussed.

  1. An Archaeal Chromosomal Autonomously Replicating Sequence Element from an Extreme Halophile, Halobacterium sp. Strain NRC-1

    PubMed Central

    Berquist, Brian R.; DasSarma, Shiladitya

    2003-01-01

    We report on the identification and first cloning of an autonomously replicating sequence element from the chromosome of an archaeon, the extreme halophile Halobacterium strain NRC-1. The putative replication origin was identified by association with the orc7 gene and replication ability in the host strain, demonstrated by cloning into a nonreplicating plasmid. Deletion analysis showed that sequences located up to 750 bp upstream of the orc7 gene translational start, plus the orc7 gene and 50 bp downstream, are sufficient to endow the plasmid with replication ability, as judged by expression of a plasmid-encoded mevinolin resistance selectable marker and plasmid recovery after transformation. Sequences located proximal to the two other chromosomally carried haloarchaeal orc genes (orc6 and orc8) are not able to promote efficient autonomous replication. Located within the 750-bp region upstream of orc7 is a nearly perfect inverted repeat of 31 bp, which flanks an extremely AT-rich (44%) stretch of 189 bp. The replication ability of the plasmid was lost when one copy of the inverted repeat was deleted. Additionally, the inverted repeat structure near orc7 homologs in the genomic sequences of two other halophiles, Haloarcula marismortui and Haloferax volcanii, is highly conserved. Our results indicate that, in halophilic archaea, a chromosomal origin of replication is physically linked to orc7 homologs and that this element is sufficient to promote autonomous replication. We discuss the finding of a functional haloarchaeal origin in relation to the large number of orc1-cdc6 homologs identified in the genomes of all haloarchaea to date. PMID:14526006

  2. Nuclear Crisis Communications: The Plan Worked. A Critique of NRC Communications in the Fukushima Daiichi Reactor Crisis - 12073

    SciTech Connect

    Brenner, Eliot; Harrington, Holly; Schmidt, Rebecca

    2012-07-01

    'Call the AV-Photo folks and get someone in here to shoot b-roll. We'll never be able to accommodate the network cameras and the only way I can get this to the media is to produce it ourselves'. Eliot Brenner, Director NRC Office of Public Affairs, March 12, 2011. For the past four years we have been speaking to audiences at Waste Management about communications issues. Last year, though we were kept from attending because of the federal budget crisis, our surrogates described to you the lessons the nuclear industry should draw from the BP Gulf oil spill crisis. Those remarks were delivered 11 days before the Fukushima Daiichi tragedy became the nuclear landmark of a generation - an industry changing event with worldwide ramifications, both in science and regulation and in communications. Eliot Brenner cut his teeth on crisis communication in the aviation industry where tragedy unfolds rapidly. He has been a speech-writer to three cabinet secretaries, spokesman for the Federal Aviation Administration and now spokesman for the Nuclear Regulatory Commission since 2004. Holly Harrington manages the NRC crisis response program and has 26 years federal public affairs experience, including eight years at the Federal Emergency Management Agency. Her crisis experience includes the 1989 Loma Prieta earthquake, numerous hurricanes and floods, Sept 11, and, now Fukushima Daiichi. Rebecca Schmidt is a veteran government relations professional whose decades in Washington include service with the House Armed Services Committee, the House Budget Committee and the Secretary of Defense. Collectively, the Offices of Public Affairs and Congressional Affairs conducted the largest outreach for the agency since Three Mile Island. We worked with the basic rule, described to Waste Management last year just 11 days before Fukushima - communicate early, often and clearly. The response - while not without its problems and lessons - went as smoothly as a chaotic event like Fukushima could go

  3. Nocturnal Hypermotor Activity during Apnea-Related Arousals

    PubMed Central

    Hoque, Romy; DelRosso, Lourdes M.

    2016-01-01

    We present a case of a 50-year-old patient who exhibits nocturnal hypermotor activity occurring exclusively during apnea-related arousals consisting of repetitive lower extremity hip-flapping. This movement is unusual and reflects a new form of lower extremity movement associated with apnea-related arousals. Citation: Hoque R, DelRosso LM. Nocturnal hypermotor activity during apnea-related arousals. J Clin Sleep Med 2016;12(9):1305–1307. PMID:27092691

  4. Seal Related Development Activities at EG/G

    NASA Technical Reports Server (NTRS)

    Greiner, Harold F.

    1991-01-01

    Seal related development activities including modeling, analysis, and performance testing are described for several current seal related projects. Among the current seal related projects are the following: high pressure gas sealing systems for turbomachinery; brush seals for gas path sealing in gas turbines; and tribological material evaluation for wear surfaces in sealing systems.

  5. Respiratory-related pharyngeal constrictor muscle activity in decerebrate cats.

    PubMed

    Kuna, S T; Vanoye, C R

    1997-11-01

    Respiratory-related activity of the hyopharyngeus (middle pharyngeal constrictor) and thyropharyngeus (inferior pharyngeal constrictor) muscles was determined in decerebrate, tracheotomized adult cats and compared with the electromyographic activity of the thyroarytenoid, a vocal cord adductor. During quiet breathing, the hyopharyngeus and usually the thyroarytenoid exhibited phasic activity during expiration and tonic activity throughout the respiratory cycle. Respiratory-related thyropharyngeus activity was absent under these conditions. Progressive hyperoxic hypercapnia and progressive isocapnic hypoxia increased phasic expiratory activity in both pharyngeal constrictor (PC) muscles but tended to suppress thyroarytenoid activity. Passively induced hypocapnia and the central apnea that followed the cessation of the mechanical hyperventilation were associated with tonic activation of the hyopharyngeus and thyroarytenoid but no recruitment in thyropharyngeus activity. The expiratory phase of a sigh and progressive pneumothorax were associated with an increase in phasic thyroarytenoid activity but no change in phasic PC activity. The results indicate that a variety of stimuli modulate respiratory-related PC activity, suggesting that the PC muscles may have a role in the regulation of upper airway patency during respiration.

  6. NRC`s proposed rulemaking on the documentation and reporting of low-level radioactive waste shipment manifest information

    SciTech Connect

    Lahs, W.R.; Haisfield, M.F.

    1991-12-31

    Since the 1982 promulgation of regulations for the land disposal of low-level radioactive waste (LLW), requirements have been in place to control transfers of LLW intended for disposal at licensed land disposal facilities. These requirements established a manifest tracking system and defined processes to control transfers of LLW intended for disposal at a land disposal facility. Because the regulations did not specify the format for the LLW shipment manifests, it was not unexpected that the two operators of the three currently operating disposal sites should each have developed their own manifest forms. The forms have many similarities and the collected information, in many cases, is identical; however, these manifests incorporate unique operator preferences and also reflect the needs of the Agreement State regulatory authority in the States where the disposal sites are located. Since Agreement State regulations must be compatible with, but need not always be identical to, those of the Nuclear Regulatory Commission (NRC), the possibility of a proliferation of different manifest forms containing variations in collected information could be envisioned. If these manifests were also to serve a shipping paper purpose, effective integration of the Department of Transportations` (DOT) requirements would also have to be addressed. This wide diversity in uses of manifest information by Federal and State regulatory authorities, other State or Compact entities, and disposal site operators, suggested a single consolidated approach to develop a uniform manifest format with a baseline information content and to define recordkeeping requirements. The NRC, in 1989, had embarked on a rulemaking activity to establish a base set of manifest information needs for regulatory purposes. In response to requests from State and Regional Compact organizations who are attempting to design, develop and operate LLW disposal facilities, and with the general support of Agreement State regulatory

  7. NRC Class 1E Digital Computer System Guidelines

    DTIC Science & Technology

    1993-05-01

    is used here to designate a specific implementation of the concept of functional diversity in which diverse plant protection algorithms operate in...parallel such that any one of the functions can activate a given safety mechanism. The broader concept of functional diversity is also applicable to...prefer to investigate functional diversity because of the application flexibility (the individual programs can be applied in various combinations and

  8. NrcR, a New Transcriptional Regulator of Rhizobium tropici CIAT 899 Involved in the Legume Root-Nodule Symbiosis

    PubMed Central

    del Cerro, Pablo; Rolla-Santos, Amanda A. P.; Valderrama-Fernández, Rocío; Gil-Serrano, Antonio; Bellogín, Ramón A.; Gomes, Douglas Fabiano; Pérez-Montaño, Francisco; Megías, Manuel; Hungría, Mariangela; Ollero, Francisco Javier

    2016-01-01

    The establishment of nitrogen-fixing rhizobium-legume symbioses requires a highly complex cascade of events. In this molecular dialogue the bacterial NodD transcriptional regulators in conjunction with plant inducers, mostly flavonoids, are responsible for the biosynthesis and secretion of Nod factors which are key molecules for successful nodulation. Other transcriptional regulators related to the symbiotic process have been identified in rhizobial genomes, including negative regulators such as NolR. Rhizobium tropici CIAT 899 is an important symbiont of common bean (Phaseolus vulgaris L.), and its genome encompasses intriguing features such as five copies of nodD genes, as well as other possible transcriptional regulators including the NolR protein. Here we describe and characterize a new regulatory gene located in the non-symbiotic plasmid pRtrCIAT899c, that shows homology (46% identity) with the nolR gene located in the chromosome of CIAT 899. The mutation of this gene, named nrcR (nolR-like plasmid c Regulator), enhanced motility and exopolysaccharide production in comparison to the wild-type strain. Interestingly, the number and decoration of Nod Factors produced by this mutant were higher than those detected in the wild-type strain, especially under salinity stress. The nrcR mutant showed delayed nodulation and reduced competitiveness with P. vulgaris, and reduction in nodule number and shoot dry weight in both P. vulgaris and Leucaena leucocephala. Moreover, the mutant exhibited reduced capacity to induce the nodC gene in comparison to the wild-type CIAT 899. The finding of a new nod-gene regulator located in a non-symbiotic plasmid may reveal the existence of even more complex mechanisms of regulation of nodulation genes in R. tropici CIAT 899 that may be applicable to other rhizobial species. PMID:27096734

  9. Activity-rotation relations for lower main-sequence stars

    SciTech Connect

    Dobson-Hockey, A.K.

    1987-01-01

    It has been known for some time that stellar rotation and activity are related, both for chromospheric activity (e.g., Noyes et al. 1984) and coronal activity (e.g., Pallavicini et al. 1981; Maggio et al. 1987). Younger, more rapidly rotating stars of a given spectral type generally show higher levels of activity than do older, more slowly rotating stars. On the Sun, activity is distinctly related to magnetic fields. This leads to the suggestion that activity, at least in solar-type stars, is traceable to a magnetic dynamo which results from the interaction of rotation and differential rotation with convection. The more efficient the coriolis forces are at introducing helicity into convective motions, the more the magnetic field will be amplified and the more activity we may expect to see. The precise nature of the relationship between magnetic fields, rotation, and activity remains to be well-defined. This thesis examines the relationship between activity (both chromospheric and coronal) and rotation in order to better define and express such a relation (or relations).

  10. Use of DandD for dose assessment under NRC`s radiological criteria for license termination rule

    SciTech Connect

    Gallegos, D.P.; Brown, T.J.; Davis, P.A.; Daily, C.

    1998-05-01

    The Decontamination and Decommissioning (DandD) software package has been developed by Sandia National Laboratories for the Nuclear Regulatory Commission (NRC) specifically for the purpose of providing a user-friendly analytical tool to address the dose criteria contained in NRC`s Radiological Criteria for License Termination rule (10 CFR Part 20 Subpart E; NRC, 1997). Specifically, DandD embodies the NRC`s screening methodology to allow licensees to convert residual radioactivity contamination levels at their site to annual dose, in a manner consistent with both 10 CFR Part 20 and the corresponding implementation guidance developed by NRC. The screening methodology employs reasonably conservative scenarios, fate and transport models, and default parameter values that have been developed to allow the NRC to quantitatively estimate the risk of releasing a site given only information about the level of contamination. Therefore, a licensee has the option of specifying only the level of contamination and running the code with the default parameter values, or in the case where site specific information is available to alter the appropriate parameter values and then calculate dose. DandD can evaluate dose for fur different scenarios: residential, building occupancy, building renovation, or drinking water. The screening methodology and DandD are part of a larger decision framework that allows and encourages licensees to optimize decisions on choice of alternative actions at their site, including collection of additional data and information. This decision framework is integrated into and documented in NRC`s technical guidance for decommissioning.

  11. Activity-rotation relations for lower main sequence stars

    NASA Astrophysics Data System (ADS)

    Dobson-Hockey, Andrea Kay

    It was known for some time that stellar rotation and activity are related, both for chromospheric activity and control activity. Younger, more rapidly rotating stars of a given spectral type generally show higher levels of activity than do older, more slowly rotating stars. On the Sun acitivity is distinctly related to magnetic fields. This leads to the suggestion that activity, at least in solar-type stars, is traceable to a magnetic dynamo which results from the interaction of rotation and differential rotation with convection. The more efficient the coriolis forces are at introducing helicity into convective motions, the more the magnetic field will be amplified and the more activity that is expected. The precise nature of the relationship between magnetic fields, rotation, and activity remains to be well-defined. It is the purpose to examine the relationship between activity and rotation in order to better define and express such a relation (or relations). To meet this goal, a comprehensive sample of stars was collected from the published literature having two or more of the following: chromospheric Ca II, H, and K emission indices; coronal soft X-ray illumination; rotation rates; and where possible, ages. It is seen that the use of normalized activity units and Rossby number generally improves the correlation between activity and rotation. The use of the convective turnover time further permits a possible explanation for the distribution of stars in an activity-color diagram. A large and homogeneous data set permits better definition of previously examined functional dependencies such as the time decay of activity and the relationship between chromospheric and coronal activity indicators.

  12. Sleep-related electrodermal activity patterns in impotent patients.

    PubMed

    Ware, J C; Karacan, I; Salis, P J; Thornby, J; Hirshkowitz, M

    1984-01-01

    The etiology of erectile failure is not always clear despite the fact that recordings of nocturnal penile tumescence (NPT) are used to detect patients with a significant organic component to their complaint. We recorded electrodermal activity in addition to NPT in 60 impotent patients. Normally more electrodermal activity occurs in stage 2 than in stage REM sleep. Despite a similar total amount of electrodermal activity, organically impotent patients tended to have less electrodermal activity in stage 2 and more in stage REM sleep than those with normal NPT. This difference was due to a subgroup of 15 organically impotent patients with less electrodermal activity in stage 2 than in stage REM sleep. Because of this difference in the pattern of electrodermal activity in relation to sleep stages, the results suggest a central nervous system change is related to impaired erectile capability and abnormal NPT in these cases.

  13. Factors Influencing Health-Related Internet Activities and Their Outcomes.

    PubMed

    Lee, Sun Young; Choi, Jounghwa; Noh, Ghee-Young

    2016-11-01

    This study explores why people participate in health-related Internet activities and what the potential impacts of such activities are. Specifically, this study examines how trust in health information (i.e., from a physician and from the Internet) determines individuals' health-related Internet activities and whether this use subsequently improves outcomes such as discussion with doctors about online health information and satisfaction with health care. Findings from a Web-based survey in South Korea indicated that trust in health information from doctors decreased communication activities, whereas trust in online health information increased both communication and information activities. Both communication and information activities increased discussions with doctors about online health information, which subsequently led to satisfaction with health care.

  14. HLRW management during MR reactor decommissioning in NRC 'Kurchatov Institute'

    SciTech Connect

    Chesnokov, Alexander; Ivanov, Oleg; Kolyadin, Vyacheslav; Lemus, Alexey; Pavlenko, Vitaly; Semenov, Sergey; Stepanov, Vyacheslav; Smirnov, Sergey; Potapov, Victor; Fadin, Sergey; Volkov, Victor; Shisha, Anatoly

    2013-07-01

    A program of decommissioning of MR research reactor in the Kurchatov institute started in 2008. The decommissioning work presumed a preliminary stage, which included: removal of spent fuel from near reactor storage; removal of spent fuel assemble of metal liquid loop channel from a core; identification, sorting and disposal of radioactive objects from gateway of the reactor; identification, sorting and disposal of radioactive objects from cells of HLRW storage of the Kurchatov institute for radwaste creating form the decommissioning of MR. All these works were performed by a remote controlled means with use of a remote identification methods of high radioactive objects. A distribution of activity along high radiated objects was measured by a collimated radiometer installed on the robot Brokk-90, a gamma image of the object was registered by gamma-visor. Spectrum of gamma radiation was measured by a gamma locator and semiconductor detector system. For identification of a presence of uranium isotopes in the HLRW a technique, based on the registration of characteristic radiation of U, was developed. For fragmentation of high radiated objects was used a cold cutting technique and dust suppression system was applied for reduction of volume activity of aerosols in air. The management of HLRW was performed by remote controlled robots Brokk-180 and Brokk-330. They executed sorting, cutting and parking of high radiated part of contaminated equipment. The use of these techniques allowed to reduce individual and collective doses of personal performed the decommissioning. The average individual dose of the personnel was 1,9 mSv/year in 2011, and the collective dose is estimated by 0,0605 man x Sv/year. Use of the remote control machines enables reducing the number of working personal (20 men) and doses. X-ray spectrometric methods enable determination of a presence of the U in high radiated objects and special cans and separation of them for further spent fuel inspection. The

  15. Adolescent Sexual Activity: Links between Relational Context and Depressive Symptoms

    ERIC Educational Resources Information Center

    Monahan, Kathryn C.; Lee, Joanna M.

    2008-01-01

    Little is known about the impact of the relational context of adolescent sexual activity on depressive symptoms. The present study examined trajectories of depressive symptoms among 6,602 adolescents (44% male, 60% White) taken from a nationally representative study (Add Health). Sexually active youth in romantic and casual relationships were…

  16. The Role of Social Activity in Age-Cognition Relations

    ERIC Educational Resources Information Center

    Soubelet, Andrea

    2013-01-01

    The goal of the current project was to examine whether engaging in social activity may moderate or mediate the relation between age and cognitive functioning. A large age range sample of adults performed a variety of cognitive tests and completed a social activities questionnaire. Results did not support the moderator hypothesis, as age…

  17. Relative Activity of Abdominal Muscles during Commonly Prescribed Strengthening Exercises.

    ERIC Educational Resources Information Center

    Willett, Gilbert M.; Hyde, Jennifer E.; Uhrlaub, Michael B.; Wendel, Cara L.; Karst, Gregory M.

    2001-01-01

    Examined the relative electromyographic (EMG) activity of upper and lower rectus abdominis (LRA) and external oblique (EOA) muscles during five abdominal strengthening exercises. Isometric and dynamic EMG data indicated that abdominal strengthening exercises activated various abdominal muscle groups. For the LRA and EOA muscle groups, there were…

  18. Relative Activity of Abdominal Muscles during Commonly Prescribed Strengthening Exercises.

    ERIC Educational Resources Information Center

    Willett, Gilbert M.; Hyde, Jennifer E.; Uhrlaub, Michael B.; Wendel, Cara L.; Karst, Gregory M.

    2001-01-01

    Examined the relative electromyographic (EMG) activity of upper and lower rectus abdominis (LRA) and external oblique (EOA) muscles during five abdominal strengthening exercises. Isometric and dynamic EMG data indicated that abdominal strengthening exercises activated various abdominal muscle groups. For the LRA and EOA muscle groups, there were…

  19. Physical Activity among Older People and Related Factors

    ERIC Educational Resources Information Center

    Persson, Ann; While, Alison

    2012-01-01

    Objective: To investigate the duration, intensity and type of physical activity undertaken by people aged 60 years and over in relation to their reported levels of participation in social activities and their perceptions of their neighbourhood. Design: A cross-sectional questionnaire survey of older people attending two luncheon and eight social…

  20. The Role of Social Activity in Age-Cognition Relations

    ERIC Educational Resources Information Center

    Soubelet, Andrea

    2013-01-01

    The goal of the current project was to examine whether engaging in social activity may moderate or mediate the relation between age and cognitive functioning. A large age range sample of adults performed a variety of cognitive tests and completed a social activities questionnaire. Results did not support the moderator hypothesis, as age…

  1. Adolescent Sexual Activity: Links between Relational Context and Depressive Symptoms

    ERIC Educational Resources Information Center

    Monahan, Kathryn C.; Lee, Joanna M.

    2008-01-01

    Little is known about the impact of the relational context of adolescent sexual activity on depressive symptoms. The present study examined trajectories of depressive symptoms among 6,602 adolescents (44% male, 60% White) taken from a nationally representative study (Add Health). Sexually active youth in romantic and casual relationships were…

  2. The impact of NRC guidance on concentration averaging on low level waste sealed source disposal - 11424

    SciTech Connect

    Whitworth, Julia; Stewart, Bill; Cuthbertson, Abigail

    2011-01-20

    As part of its ongoing efforts to revise the Nuclear Regulatory Commission's (NRC) current position on blending to be risk-informed and performance based and its current review of the low-level waste classification codified in 10 CFR 61.55, the Nuclear Regulatory Commission (NRC) has stated that it may review the 1995 'Branch Technical Position on Concentration Averaging and Encapsulation' (BTP), which is still commonly used today. Such a review will have timely advantages, given the lack of commercial disposal availability within the United States for radioactive sealed sources that are in wide beneficial use across the country. The current application of the BTP guidance has resulted in an effective cap on commercial disposal for sources larger than 1.1 TBq (30 Ci). This paper will analyze how the BTP has been implemented with respect to sealed sources, what the implications have been for commercial disposal availability, and whether alternative packaging configurations could be considered for disposal.

  3. Reassessment of NRC`s dollar per person-rem conversion factor policy

    SciTech Connect

    1995-12-01

    The US Nuclear Regulatory Commission (NRC) has completed a review and analysis of its dollar per person-rem conversion factor policy. As a result of this review, the NRC has decided to adopt a $2000 per person-rem conversion factor, subject it to present worth considerations, and limit its scope solely to health effects. This is in contrast to the previous policy and staff practice of using an undiscounted $1000 per person-rem conversion factor that served as a surrogate for all offsite consequences (health and offsite property). The policy shift has been incorporated in ``Regulatory Analysis Guidelines of the US Nuclear Regulatory Commission,`` NUREG/BR-0058, Revision 2, November 1995.

  4. Problems plague startup of Palo Verde nukes: NRC proposes fines for QA deficiencies, records falsification

    SciTech Connect

    Not Available

    1984-01-01

    Defective coolant pump design in unit one and a failure to get adequate rate relief from the Arizona Corporation Commission to cover the 16% cost overruns are delaying commercial operation at Phoenix's Palo Verde nuclear plant. Arizona Public Service (APS) Company's deteriorating financial situation caused the utility to scrap a program to credit customers who purchase energy-saving devices and threatens more extreme action. The Nuclear Regulatory Commission fined APS for alleged quality assurance (QA) violations following a construction appraisal inspection at unit one and reports of falsified installation records. APS argues that its own inspectors would have found the missing bolts and the caps installed on pressure-sensing lines, but concedes the QA lapses. The company challenges NRC's report of a possible 150 falsifications, and concedes only one. The NRC imposes a $40,000 fine on each violation. (DCK)

  5. EPRI/NRC workshop on nuclear power plant reevaluation to quantify seismic margins: proceedings

    SciTech Connect

    Not Available

    1985-08-01

    A three-day workshop on nuclear power plant reevaluation to quantify seismic margins was held in San Francisco on October 15-17, 1984. The workshop was cosponsored by the Nuclear Regulatory Commission and the Electric Power Research Institute. The primary objective of the workshop was to develop technical strategies by which utilities could demonstrate and the NRC could evaluate seismic margins for existing nuclear plants. These proceedings contain the text of the formal technical presentations as well as summaries of the working group sessions. Thirteen technical papers as well as NRC and EPRI reserach programs were presented at the technical sessions. Four working group discussion sessions were then held in the geotechnical/structural, piping, and equipment areas. Each group provided a forum for participants to exchange ideas and to discuss in more depth the criteria, methods and needs for plant seismic reevaluation. Recommendations from the working groups were summarized and presented at the end of the workshop.

  6. Results from the NRC AP600 testing program at the Oregon State University APEX facility

    SciTech Connect

    Reyes, J.N. Jr.; Bessette, D.E.; DiMarzo, M.

    1996-03-01

    The Department of Nuclear Engineering at Oregon State University (OSU) is performing a series of confirmatory tests for the U.S. Nuclear Regulatory Commission. These tests are being conducted in the Advanced Plant Experiment (APEX) facility which is a 1/4 length scale and 1/192 volume scale integral system simulation of the Westinghouse Advanced Passive 600 MWe (AP600) plant. The purpose of the testing program is to examine AP600 passive safety system performance, particularly during long term cooling. Thus far, OSU has successfully performed ten integral system tests for the NRC. This paper presents a description of the APEX facility and summarizes the important results of the NRC test program at OSU.

  7. Transportation as a "Related Service": Issues that Involve Transition Activities.

    ERIC Educational Resources Information Center

    Missouri Univ., Columbia. Missouri LINC.

    The paper discusses transportation as a related service for students with disabilities expecially as related to school-to-work transition activities. First, the legislative and legal basis for providing transportation services is discussed in the form of answers to frequently asked questions: why provide transportation? what is the basis for…

  8. Human Relations Education; A Guidebook to Learning Activities.

    ERIC Educational Resources Information Center

    Buffalo Public Schools, NY. Human Relations Project of Western New York.

    This guidebook is designed to acquaint teachers with human relations classroom materials, extracurricular activities, and an inservice approach to self-evaluation. A product of an ESEA Title III program, it contains human relations-oriented lessons--divided by grade level and subject matter--intended to supplement or enrich existing curricula and…

  9. Occupational Employment in Nuclear-Related Activities, 1981.

    ERIC Educational Resources Information Center

    Baker, Joe G.; Olsen, Kathryn

    Employment in nuclear- and nuclear energy-related activities in 1981 was examined and compared to that in previous years. Survey instruments were returned by 784 establishments. Total 1981 nuclear-related employment was estimated to be 249,500--a growth of 22,600 (10%) workers over the 1977 total. Government-owned, contractor-operated (GOCO)…

  10. Transportation as a "Related Service": Issues that Involve Transition Activities.

    ERIC Educational Resources Information Center

    Missouri Univ., Columbia. Missouri LINC.

    The paper discusses transportation as a related service for students with disabilities expecially as related to school-to-work transition activities. First, the legislative and legal basis for providing transportation services is discussed in the form of answers to frequently asked questions: why provide transportation? what is the basis for…

  11. Proceedings of the 23rd DOE/NRC nuclear air cleaning conference

    SciTech Connect

    First, M.W.

    1995-02-01

    The report contains the papers presented at the 23rd DOE/NRC Nuclear Air Cleaning Conference and the associated discussions. Major topics are: (1) nuclear air cleaning codes, (2) nuclear waste, (3) filters and filtration, (4) effluent stack monitoring, (5) gas processing, (6) adsorption, (7) air treatment systems, (8) source terms and accident analysis, and (9) fuel reprocessing. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  12. Arsenic resistance in Halobacterium sp. strain NRC-1 examined by using an improved gene knockout system.

    PubMed

    Wang, Gejiao; Kennedy, Sean P; Fasiludeen, Sabeena; Rensing, Christopher; DasSarma, Shiladitya

    2004-05-01

    The genome sequence of Halobacterium sp. strain NRC-1 encodes genes homologous to those responsible for conferring resistance to arsenic. These genes occur on both the large extrachromosomal replicon pNRC100 (arsADRC and arsR2M) and on the chromosome (arsB). We studied the role of these ars genes in arsenic resistance genetically by construction of gene knockouts. Deletion of the arsADRC gene cluster in a Halobacterium NRC-1 Deltaura3 strain resulted in increased sensitivity to arsenite and antimonite but not arsenate. In contrast, knockout of the chromosomal arsB gene did not show significantly increased sensitivity to arsenite or arsenate. We also found that knockout of the arsM gene produced sensitivity to arsenite, suggesting a second novel mechanism of arsenic resistance involving a putative arsenite(III)-methyltransferase. These results indicate that Halobacterium sp. strain NRC-1 contains an arsenite and antimonite extrusion system with significant differences from bacterial counterparts. Deletion analysis was facilitated by an improved method for gene knockouts/replacements in Halobacterium that relies on both selection and counterselection of ura3 using a uracil dropout medium and 5-fluoroorotic acid. The arsenite and antimonite resistance elements were shown to be regulated, with resistance to arsenic in the wild type inducible by exposure to a sublethal concentration of the metal. Northern hybridization and reverse transcription-PCR analyses showed that arsA, arsD, arsR, arsM, arsC, and arsB, but not arsR2, are inducible by arsenite and antimonite. We discuss novel aspects of arsenic resistance in this halophilic archaeon and technical improvements in our capability for gene knockouts in the genome.

  13. Arsenic Resistance in Halobacterium sp. Strain NRC-1 Examined by Using an Improved Gene Knockout System

    PubMed Central

    Wang, Gejiao; Kennedy, Sean P.; Fasiludeen, Sabeena; Rensing, Christopher; DasSarma, Shiladitya

    2004-01-01

    The genome sequence of Halobacterium sp. strain NRC-1 encodes genes homologous to those responsible for conferring resistance to arsenic. These genes occur on both the large extrachromosomal replicon pNRC100 (arsADRC and arsR2M) and on the chromosome (arsB). We studied the role of these ars genes in arsenic resistance genetically by construction of gene knockouts. Deletion of the arsADRC gene cluster in a Halobacterium NRC-1 Δura3 strain resulted in increased sensitivity to arsenite and antimonite but not arsenate. In contrast, knockout of the chromosomal arsB gene did not show significantly increased sensitivity to arsenite or arsenate. We also found that knockout of the arsM gene produced sensitivity to arsenite, suggesting a second novel mechanism of arsenic resistance involving a putative arsenite(III)-methyltransferase. These results indicate that Halobacterium sp. strain NRC-1 contains an arsenite and antimonite extrusion system with significant differences from bacterial counterparts. Deletion analysis was facilitated by an improved method for gene knockouts/replacements in Halobacterium that relies on both selection and counterselection of ura3 using a uracil dropout medium and 5-fluoroorotic acid. The arsenite and antimonite resistance elements were shown to be regulated, with resistance to arsenic in the wild type inducible by exposure to a sublethal concentration of the metal. Northern hybridization and reverse transcription-PCR analyses showed that arsA, arsD, arsR, arsM, arsC, and arsB, but not arsR2, are inducible by arsenite and antimonite. We discuss novel aspects of arsenic resistance in this halophilic archaeon and technical improvements in our capability for gene knockouts in the genome. PMID:15126481

  14. Synapse formation is arrested in retinal photoreceptors of the zebrafish nrc mutant.

    PubMed

    Allwardt, B A; Lall, A B; Brockerhoff, S E; Dowling, J E

    2001-04-01

    We describe the effects of a recessive mutation on visual behavior, the electroretinogram (ERG), and photoreceptor structure in zebrafish. At 6 d post-fertilization (dpf), no optokinetic reflex could be elicited in no optokinetic response c (nrc) mutant animals under any test condition. The animals exhibited ERG responses at 5-7 dpf that were markedly abnormal and could be categorized into two groups. The first showed an initial negative a-wave followed by a delayed positive b-wave of small amplitude. Often a second ERG-like response was recorded after the initial b-wave. The second group showed only a large negative a-wave; an initial b-wave was not evident. In most recordings additional oscillatory waves varying in number, amplitude, and time course were observed. Multiple responses at the cessation of long-duration flashes were also observed. Light and electron microscopy revealed that the cone photoreceptor pedicles of nrc fish were highly abnormal. Although the appropriate number of synaptic ribbons formed in these terminals, they "floated" in the terminal, unassociated with postsynaptic processes or arciform densities. The few processes invaginating the nrc pedicles resembled those of horizontal cells. Invaginating bipolar cell processes were rare, but basal contacts were observed on pedicle surfaces. The severity of the mutation did not change between 6 and 8 dpf, showing that there is neither a delay in development nor a degeneration of the terminals; rather, nrc pedicle development appears arrested. Bipolar cell terminals in the inner plexiform layer made normal ribbon synapses; thus, the mutation appears to affect only the outer retina.

  15. Visual short term memory related brain activity predicts mathematical abilities.

    PubMed

    Boulet-Craig, Aubrée; Robaey, Philippe; Lacourse, Karine; Jerbi, Karim; Oswald, Victor; Krajinovic, Maja; Laverdière, Caroline; Sinnett, Daniel; Jolicoeur, Pierre; Lippé, Sarah

    2017-07-01

    Previous research suggests visual short-term memory (VSTM) capacity and mathematical abilities are significantly related. Moreover, both processes activate similar brain regions within the parietal cortex, in particular, the intraparietal sulcus; however, it is still unclear whether the neuronal underpinnings of VSTM directly correlate with mathematical operation and reasoning abilities. The main objective was to investigate the association between parieto-occipital brain activity during the retention period of a VSTM task and performance in mathematics. The authors measured mathematical abilities and VSTM capacity as well as brain activity during memory maintenance using magnetoencephalography (MEG) in 19 healthy adult participants. Event-related magnetic fields (ERFs) were computed on the MEG data. Linear regressions were used to estimate the strength of the relation between VSTM related brain activity and mathematical abilities. The amplitude of parieto-occipital cerebral activity during the retention of visual information was related to performance in 2 standardized mathematical tasks: mathematical reasoning and calculation fluency. The findings show that brain activity during retention period of a VSTM task is associated with mathematical abilities. Contributions of VSTM processes to numerical cognition should be considered in cognitive interventions. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  16. [Human social activity under conditions of relative social isolation].

    PubMed

    Prokhvatilov, A Iu

    1992-01-01

    The differences in using a "social isolation" concept in the psychological literature are presented. The term of "relative social isolation" is clarified. A relationship between human adaptation to the relative social isolation environments and the development of his social qualities and social activities is presented. The "social context", dictating motivation attitudes of a man to the isolation situation, emotional experiences, self-appraisal of activity is of crucial importance for evaluating the real environments of relative social isolations. Social activity of a personality is studied as the relations of a man with the conditions of his activity. The results of studying the dynamics of the psychic state of a man during individual and group isolation are compared. It is concluded that social activity of man and his functional state are interrelated. The particular manifestations and direction of the changes in the social activity of the subject depend on the duration of isolation and are determined first of all by social significance and meaningful and balanced work for a person as well as by the amount and frequency of direct and mediated social contacts under specific conditions of relative social isolation.

  17. Factors related to physical activity: a study of adolescents.

    PubMed

    Vilhjalmsson, R; Thorlindsson, T

    1998-09-01

    Although the consequences of physical activity have been carefully documented, less is known about its correlates, particularly among children and youth. Based on a representative national survey of 1131 Icelandic adolescents, the study examined various physical, psychological, social and demographic factors related to physical activity. Male sex, significant others' involvement in physical activity (father, friend and older brother), sociability, perceived importance of sport and of health improvement and satisfaction with mandatory gym classes in school, were all related to more involvement, whereas hours of paid work and TV-viewing were related to less. Furthermore, the data suggested that the influence of friend's participation in physical activity depends on his or her emotional significance. Influential others appeared to affect males and females in the same way. The meaning of the results and their implications for future research are discussed.

  18. Social power and approach-related neural activity

    PubMed Central

    Smolders, Ruud; Cremer, David De

    2012-01-01

    It has been argued that power activates a general tendency to approach whereas powerlessness activates a tendency to inhibit. The assumption is that elevated power involves reward-rich environments, freedom and, as a consequence, triggers an approach-related motivational orientation and attention to rewards. In contrast, reduced power is associated with increased threat, punishment and social constraint and thereby activates inhibition-related motivation. Moreover, approach motivation has been found to be associated with increased relative left-sided frontal brain activity, while withdrawal motivation has been associated with increased right sided activations. We measured EEG activity while subjects engaged in a task priming either high or low social power. Results show that high social power is indeed associated with greater left-frontal brain activity compared to low social power, providing the first neural evidence for the theory that high power is associated with approach-related motivation. We propose a framework accounting for differences in both approach motivation and goal-directed behaviour associated with different levels of power. PMID:19304842

  19. Social power and approach-related neural activity.

    PubMed

    Boksem, Maarten A S; Smolders, Ruud; De Cremer, David

    2012-06-01

    It has been argued that power activates a general tendency to approach whereas powerlessness activates a tendency to inhibit. The assumption is that elevated power involves reward-rich environments, freedom and, as a consequence, triggers an approach-related motivational orientation and attention to rewards. In contrast, reduced power is associated with increased threat, punishment and social constraint and thereby activates inhibition-related motivation. Moreover, approach motivation has been found to be associated with increased relative left-sided frontal brain activity, while withdrawal motivation has been associated with increased right sided activations. We measured EEG activity while subjects engaged in a task priming either high or low social power. Results show that high social power is indeed associated with greater left-frontal brain activity compared to low social power, providing the first neural evidence for the theory that high power is associated with approach-related motivation. We propose a framework accounting for differences in both approach motivation and goal-directed behaviour associated with different levels of power.

  20. Development of probabilistic RESRAD computer codes for NRC decommissioning and license termination applications.

    SciTech Connect

    Chen, S. Y.; Yu, C.; Mo. T.; Trottier, C.

    2000-10-17

    In 1999, the US Nuclear Regulatory Commission (NRC) tasked Argonne National Laboratory to modify the existing RESRAD and RESRAD-BUILD codes to perform probabilistic, site-specific dose analysis for use with the NRC's Standard Review Plan for demonstrating compliance with the license termination rule. The RESRAD codes have been developed by Argonne to support the US Department of Energy's (DOEs) cleanup efforts. Through more than a decade of application, the codes already have established a large user base in the nation and a rigorous QA support. The primary objectives of the NRC task are to: (1) extend the codes' capabilities to include probabilistic analysis, and (2) develop parameter distribution functions and perform probabilistic analysis with the codes. The new codes also contain user-friendly features specially designed with graphic-user interface. In October 2000, the revised RESRAD (version 6.0) and RESRAD-BUILD (version 3.0), together with the user's guide and relevant parameter information, have been developed and are made available to the general public via the Internet for use.

  1. Purification and characterization of gamma poly glutamic acid from newly Bacillus licheniformis NRC20.

    PubMed

    Tork, Sanaa E; Aly, Magda M; Alakilli, Saleha Y; Al-Seeni, Madeha N

    2015-03-01

    γ-poly glutamic acid (γ-PGA) has received considerable attention for pharmaceutical and biomedical applications. γ-PGA from the newly isolate Bacillus licheniformis NRC20 was purified and characterized using diffusion distance agar plate, mass spectrometry and thin layer chromatography. All analysis indicated that γ-PGA is a homopolymer composed of glutamic acid. Its molecular weight was determined to be 1266 kDa. It was composed of L- and D-glutamic acid residues. An amplicon of 3050 represents the γ-PGA-coding genes was obtained, sequenced and submitted in genbank database. Its amino acid sequence showed high similarity with that obtained from B. licheniformis strains. The bacterium NRC 20 was independent of L-glutamic acid but the polymer production enhanced when cultivated in medium containing L-glutamic acid as the sole nitrogen source. Finally we can conclude that γ-PGA production from B. licheniformis NRC20 has many promised applications in medicine, industry and nanotechnology. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Comparison of realizations of Re-C fixed points filled and measured at NPL and NRC

    NASA Astrophysics Data System (ADS)

    Todd, A. D. W.; Lowe, D. H.; Dong, W.; Woods, D. J.

    2013-09-01

    A Re-C fixed point was filled at the National Physical Laboratory (NPL), UK and its melting temperature compared to a fixed point that had been filled previously at NPL. Both of these fixed points were of the hybrid type and used a purified graphite foil between the sacrificial graphite sleeve and the outer crucible. The melting temperatures of these two fixed points were compared and found to agree within the comparison uncertainties. Another Re-C fixed point was filled at the National Research Council (NRC), Canada. This fixed point was also of the hybrid type but contained carbon-composite sheet as the liner between the sleeve and the outer crucible. The melting temperatures of the fixed point filled at NPL and the one filled at NRC were compared and found to agree within the uncertainties of the comparison. When the ITS-90 temperatures at the Re-C melting point (˜ 2474 °C) measured at NPL were compared to those measured at NRC they were also found to agree within the uncertainties of their respective scales.

  3. Conservation Activities Related to Energy: Energy Activities for Urban Elementary Students, K-6.

    ERIC Educational Resources Information Center

    Schmidt, Joan S.; And Others

    Presented are simple activities, experiments, and demonstrations relating to energy conservation in the home. Activities are divided into four areas: (1) kitchen, (2) house, (3) transportation, and (4) heating and cooling. The material has been designed to require a minimum of preparation. Activity and game masters are provided. Activities may be…

  4. Active relatives and health-related physical fitness in European adolescents: the HELENA Study.

    PubMed

    Martín-Matillas, Miguel; Ortega, Francisco B; Ruiz, Jonatan R; Martínez-Gómez, David; Vicente-Rodríguez, Germán; Marcos, Ascensión; Béghin, Laurent; Kafatos, Anthony; González-Gross, Marcela; Zaccaria, Maria; Molnár, Dénes; De Henauw, Stefaan; Sjöström, Michael; Moreno, Luis A; Castillo, Manuel J

    2012-01-01

    High physical fitness in childhood and adolescence is positively associated with favourable health-related outcomes. Our aim was to examine the relationship between relatives' (father, mother, brother, sister, and best friend) physical activity engagement and encouragement on adolescents' physical fitness. Adolescents were part of the HELENA study, a multi-centre study conducted in 10 cities from nine European countries in 2006-2008. Participants were 3288 adolescents (48% boys, 52% girls) aged 12.5-17.5 years with valid data on at least one of the three fitness variables studied: muscular strength (standing long jump), speed/agility (4×10 m shuttle run), and cardiorespiratory fitness (20 m shuttle run). The adolescents reported their relatives' physical activity engagement and encouragement. Analysis of covariance showed that relatives' physical activity engagement (father, mother, brother, and best friend) was positively related to cardiorespiratory fitness (P < 0.05); and mother's and sisters' physical activity engagement were positively associated with higher muscular strength in adolescents (P < 0.05). Furthermore, father's physical activity encouragement was positively linked to physical fitness (all fitness components) in adolescents (P < 0.05). Interventions aimed at improving physical fitness in young people might be more successful when family members, particularly mothers and fathers, are encouraged to engage in physical activity and support adolescents' physical activity.

  5. Respiratory-related activation of human abdominal muscles during exercise

    PubMed Central

    Abraham, Kirk A; Feingold, Howard; Fuller, David D; Jenkins, Megan; Mateika, Jason H; Fregosi, Ralph F

    2002-01-01

    We tested the hypothesis that abdominal muscles are active during the expiratory phase of the respiratory cycle during exercise. Electromyographic (EMG) activities of external oblique and rectus abdominis muscles were recorded during incremental exercise to exhaustion and during 30 min of constant work rate exercise at an intensity of 85 % of the peak oxygen consumption rate (V̇O2). High amplitude intramuscular EMG activities of both abdominal muscles could be evoked with postural manoeuvres in all subjects. During cycling, respiratory-related activity of the external obliques was evoked in four of seven subjects, whereas rectus abdominis activity was observed in six of the seven subjects. We measured only the activity that was confined exclusively to the expiratory phase of the respiratory cycle. Expiratory activity of both muscles increased with exercise intensity, although peak values averaged only 10-20 or 20-40 % of the peak activity (obtained during maximal, voluntary expiratory efforts) for the external oblique and rectus abdominis muscles, respectively. To estimate how much of the recorded abdominal muscle activity was supporting leg movements during exercise, we compared the activity at the very end of incremental exercise to that recorded during the first five respiratory cycles after the abrupt cessation of exercise, when ventilation was still very high. Although external oblique activity was reduced after exercise stopped, clear expiratory activity remained. Rectus abdominis activity remained high after exercise cessation, showing a gradual decline that approximated the decline in ventilation. During constant work rate exercise, EMG activities increased to 40-50 and 5-10 % of peak in rectus and external oblique muscles, respectively, and then plateaued for the remainder of the bout in spite of a continual upward drift in V̇O2 and pulmonary ventilation. Linear regression analysis showed that the rise in respiratory-related expiratory muscle activity

  6. 2011 Health Related Behaviors Survey of Active Duty Military Personnel

    DTIC Science & Technology

    2013-02-01

    to be sociable (33.4%). The most commonly ES-8 Executive Summary to the 2011 Health Related Behaviors Survey of Active Duty Military Personnel 20...standards and current best practices in the field of survey research. Although the target population and the topics addressed in the 2011 HRB were...enlisted, active duty military personnel to identify any items or survey instructions that were unclear. It is a best practice to pretest the survey

  7. Proposed NRC portable target case for short-range triangulation-based 3D imaging systems characterization

    NASA Astrophysics Data System (ADS)

    Carrier, Benjamin; MacKinnon, David; Cournoyer, Luc; Beraldin, J.-Angelo

    2011-03-01

    The National Research Council of Canada (NRC) is currently evaluating and designing artifacts and methods to completely characterize 3-D imaging systems. We have gathered a set of artifacts to form a low-cost portable case and provide a clearly-defined set of procedures for generating characteristic values using these artifacts. In its current version, this case is specifically designed for the characterization of short-range (standoff distance of 1 centimeter to 3 meters) triangulation-based 3-D imaging systems. The case is known as the "NRC Portable Target Case for Short-Range Triangulation-based 3-D Imaging Systems" (NRC-PTC). The artifacts in the case have been carefully chosen for their geometric, thermal, and optical properties. A set of characterization procedures are provided with these artifacts based on procedures either already in use or are based on knowledge acquired from various tests carried out by the NRC. Geometric dimensioning and tolerancing (GD&T), a well-known terminology in the industrial field, was used to define the set of tests. The following parameters of a system are characterized: dimensional properties, form properties, orientation properties, localization properties, profile properties, repeatability, intermediate precision, and reproducibility. A number of tests were performed in a special dimensional metrology laboratory to validate the capability of the NRC-PTC. The NRC-PTC will soon be subjected to reproducibility testing using an intercomparison evaluation to validate its use in different laboratories.

  8. State Legislation Related to Increasing Physical Activity: 2006-2012

    PubMed Central

    Eyler, Amy A.; Budd, Elizabeth; Camberos, Gabriela J.; Yan, Yan; Brownson, Ross C.

    2016-01-01

    Background Strategies to improve physical activity prevalence often include policy and environmental changes. State-level policies can be influential in supporting access and opportunities for physical activity in schools and communities. The purpose of this study was to explore the prevalence of state legislation related to physical activity and identify the correlates of enactment of this legislation. Methods An online legislative database was used to collect bills from 50 states in the U.S. from 2006-2012 for ten topics related to physical activity. Bills were coded for content and compiled into a database with state-level variables (e.g., obesity prevalence). With enactment status as the outcome, bivariate and multivariate analyses were conducted. Results Of the 1542 bills related to physical activity introduced, 30% (N=460) were enacted. Bills on public transportation and trails were more likely to be enacted than those without these topics. Primary sponsorship by the Republican Party, bipartisan sponsorship, and mention of specific funding amounts were also correlates of enactment. Conclusion Policy surveillance of bills and correlates of enactment are important for understanding patterns in legislative support for physical activity. This information can be used to prioritize advocacy efforts and identify ways for research to better inform policy. PMID:26104603

  9. Body-related self-conscious emotions relate to physical activity motivation and behavior in men.

    PubMed

    Castonguay, Andree L; Pila, Eva; Wrosch, Carsten; Sabiston, Catherine M

    2015-05-01

    The aim of this study was to examine the associations between the body-related self-conscious emotions of shame, guilt, and pride and physical activity motivation and behavior among adult males. Specifically, motivation regulations (external, introjected, indentified, intrinsic) were examined as possible mediators between each of the body-related self-conscious emotions and physical activity behavior. A cross-sectional study was conducted with adult men (N = 152; Mage = 23.72, SD = 10.92 years). Participants completed a questionnaire assessing body-related shame, guilt, authentic pride, hubristic pride, motivational regulations, and leisure-time physical activity. In separate multiple mediation models, body-related shame was positively associated with external and introjected regulations and negatively correlated with intrinsic regulation. Guilt was positively linked to external, introjected, and identified regulations. Authentic pride was negatively related to external regulation and positively correlated with both identified and intrinsic regulations and directly associated with physical activity behavior. Hubristic pride was positively associated with intrinsic regulation. Overall, there were both direct and indirect effects via motivation regulations between body-related self-conscious emotions and physical activity (R(2) shame = .15, guilt = .16, authentic pride = .18, hubristic pride = .16). These findings highlight the importance of targeting and understanding self-conscious emotions contextualized to the body and links to motivation and positive health behavior among men.

  10. Relations between anthropometric parameters and sexual activity of Hungarian men.

    PubMed

    Rurik, I; Szigethy, E; Fekete, F; Langmár, Z

    2012-01-01

    In the last decades, there were visible achievements in the evaluation of sexuality-related problems and issues regarding sexual life. However, there are limited reliable and comparable data on the average values of sexual activity and its relation to anthropometric parameters in different populations and age cohorts. This study tries to examine the association between anthropometric parameters and male sexual activity. A clinical population of 1146 male patients between 25 and 45 years of age attending an outpatient clinic of andrology in Budapest (Hungary) was examined and questioned in a medical setting. Age, body height, weight, body mass index (BMI) and self-reported sexual activity were the main outcome measures. The patients were allotted into age groups (25-29, 30-39 and 40-45 years), the youngest group showing the highest coital activity. Although obesity and overweight were present in 61% of the study population, no connections between BMI and sexual activity were apparent. Comparing less active persons with those reporting at least two intercourses per week, significant difference was found between body height groups. Men below 170 cm reported higher activity than men over 180 cm. Despite the fact that the prevalence of obesity among younger generations is increasing, it has had no visible influence on the sexual activity of this age cohort as yet. Our data suggest that sexual activity was not clearly related to other anthropometric parameters, and depends mainly on the characteristics of the population examined. There is a great need for large-scale studies worldwide on larger representative samples, using similar methods, to acquire reliable data from other nations and different age groups.

  11. Utilizing the National Research Council's (NRC) Conceptual Framework for the Next Generation Science Standards (NGSS): A Self-Study in My Science, Engineering, and Mathematics Classroom

    NASA Astrophysics Data System (ADS)

    Corvo, Arthur Francis

    Given the reality that active and competitive participation in the 21 st century requires American students to deepen their scientific and mathematical knowledge base, the National Research Council (NRC) proposed a new conceptual framework for K--12 science education. The framework consists of an integration of what the NRC report refers to as the three dimensions: scientific and engineering practices, crosscutting concepts, and core ideas in four disciplinary areas (physical, life and earth/spaces sciences, and engineering/technology). The Next Generation Science Standards (NGSS ), which are derived from this new framework, were released in April 2013 and have implications on teacher learning and development in Science, Technology, Engineering, and Mathematics (STEM). Given the NGSS's recent introduction, there is little research on how teachers can prepare for its release. To meet this research need, I implemented a self-study aimed at examining my teaching practices and classroom outcomes through the lens of the NRC's conceptual framework and the NGSS. The self-study employed design-based research (DBR) methods to investigate what happened in my secondary classroom when I designed, enacted, and reflected on units of study for my science, engineering, and mathematics classes. I utilized various best practices including Learning for Use (LfU) and Understanding by Design (UbD) models for instructional design, talk moves as a tool for promoting discourse, and modeling instruction for these designed units of study. The DBR strategy was chosen to promote reflective cycles, which are consistent with and in support of the self-study framework. A multiple case, mixed-methods approach was used for data collection and analysis. The findings in the study are reported by study phase in terms of unit planning, unit enactment, and unit reflection. The findings have implications for science teaching, teacher professional development, and teacher education.

  12. Substrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry.

    PubMed

    Gladysz, Rafaela; Lambeir, Anne-Marie; Joossens, Jurgen; Augustyns, Koen; Van der Veken, Pieter

    2016-03-04

    Substrate activity screening (SAS) was presented a decade ago by Ellman and co-workers as a straightforward methodology for the identification of fragment-sized building blocks for enzyme inhibitors. Ever since, SAS and variations derived from it have been successfully applied to the discovery of inhibitors of various families of enzymatically active drug targets. This review covers key achievements and challenges of SAS and related methodologies, including the modified substrate activity screening (MSAS) approach. Special attention is given to the kinetic and thermodynamic aspects of these methodologies, as a thorough understanding thereof is crucial for successfully transforming the identified fragment-sized hits into potent inhibitors.

  13. Psychosocial Variables Related to Why Women are Less Active than Men and Related Health Implications

    PubMed Central

    Edwards, Elizabeth Skidmore; Sackett, Sarah Carson

    2016-01-01

    This article reviews psychosocial influences on women’s participation in physical activity as they differ from men and how associated activity differences impact women’s risk for a number of chronic diseases. This topic directly aligns with the mission of this special edition related to disparities in women’s health as the typically lower level of physical activity in females directly impacts their health. On average, females participate in physical activity at lower rates than their male counterparts. These lower rates of physical activity are directly related to both incidence of and outcomes from cardiovascular disease, type 2 diabetes, and breast and gynecological cancers. The relationship between psychosocial factors that are understood to affect physical activity differs between men and women. Specifically, self-efficacy, social support, and motivation are empirically substantiated factors that found to impact physical activity participation among women differently than men. Understanding these relationships is integral to designing effective interventions to target physical activity participation in women so that the related health risks are adequately addressed. PMID:27398045

  14. Origins of choice-related activity in mouse somatosensory cortex

    PubMed Central

    Yang, Hongdian; Kwon, Sung E.; Severson, Kyle S.; O’Connor, Daniel H.

    2015-01-01

    During perceptual decisions about faint or ambiguous sensory stimuli, even identical stimuli can produce different choices. Spike trains from sensory cortex neurons can predict trial-to-trial variability in choice. Choice-related spiking is widely studied to link cortical activity to perception, but its origins remain unclear. Using imaging and electrophysiology, we found that mouse primary somatosensory cortex neurons showed robust choice-related activity during a tactile detection task. Spike trains from primary mechanoreceptive neurons did not predict choices about identical stimuli. Spike trains from thalamic relay neurons showed highly transient, weak choice-related activity. Intracellular recordings in cortex revealed a prolonged choice-related depolarization in most neurons that was not accounted for by feedforward thalamic input. Top-down axons projecting from secondary to primary somatosensory cortex signaled choice. An intracellular measure of stimulus sensitivity determined which neurons converted choice-related depolarization into spiking. Our results reveal how choice-related spiking emerges across neural circuits and within single neurons. PMID:26642088

  15. The relation between star formation and active nuclei

    NASA Technical Reports Server (NTRS)

    Rieke, G. H.

    1987-01-01

    Three questions relevant to the relation between an active nucleus and surrounding star formation are discussed. The infrared stellar CO absorption bands can be used to identify galaxies with large populations of young, massive stars and thus can identify strong starburst unambiguously, such as in NGC 6240, and can help identify composite active/starburst systems such as Arp 220. An active nucleus is probably not required for LINER spectral characteristics; dusty starburst galaxies, particularly if they are nearly edge-on, can produce LINER spectra through the shock heating of their interstellar media by supernovae combined with the obscuration of their nuclei in the optical. The Galactic Center would be an ideal laboratory for studying the interaction of starbursts and active nuclei, if both could be demonstrated to occur there. Failure to detect a cusp in the stellar distribution raises questions about the presence of an active nucleus, which should be answered by additional observations in the near future.

  16. Steroid hormone activity of flavonoids and related compounds.

    PubMed

    Zand, R S; Jenkins, D J; Diamandis, E P

    2000-07-01

    Soy isoflavones have been studied extensively for estrogenic and antiestrogenic properties. Other flavonoids, found in fruits, vegetables, tea and wine, have been much less tested for steroid hormone activity. We therefore assessed the estrogenic, androgenic and progestational activities of 72 flavonoids and structurally-related compounds. These compounds were tested on BT-474 human breast cancer cells at concentrations of 10(8)-10(-5) M, with estradiol (estrogen), norgestrel (progestin) and dihydrotestosterone (androgen) used as positive controls, and ethanol (solvent) as a negative control. pS2, an estrogen-regulated protein, and prostate-specific antigen (PSA), regulated by androgens and progestins, were quantified in tissue culture supernatants using ELISA-type immunofluorometric assays developed in-house. Of the 72 compounds tested, 18 showed estrogenic activity at 10(-5) M. Of this subset, seven also showed progestational activity at this concentration. The soy isoflavones, biochanin A and genistein, showed the most potent estrogenic activity, with a dose-response effect up to 10(-7) M. Of all other flavonoids, luteolin and naringenin displayed the strongest estrogenicity, while apigenin had a relatively strong progestational activity. Based on our data, we have formulated a set of structure/function relationships between the tested compounds. Flavonoids, therefore, exhibit significant steroid hormone activity, and may have an effect in the modification of cancer risk by diet, or in cancer therapeutics and prevention.

  17. ADS-33C related handling qualities research performed using the NRC Bell 205 airborne simulator

    NASA Technical Reports Server (NTRS)

    Morgan, J. Murray; Baillie, Stewart W.

    1993-01-01

    Over 10 years ago a project was initiated by the U.S. Army AVSCOM to update the military helicopter flying qualities specification MIL-8501-A. While not yet complete, the project reached a major milestone in 1989 with the publication of an Airworthiness Design Standard, ADS-33C. The 8501 update project initially set out to identify critical gaps in the requisite data base and then proceeded to fill them using a variety of directed research studies. The magnitude of the task required that it become an international effort: appropriate research studies were conducted in Germany, the UK and Canada as well as in the USA. Canadian participation was supported by the Department of National Defence (DND) through the Chief of Research and Development. Both ground based and in-flight simulation were used to study the defined areas and the Canadian Bell 205-A1 variable stability helicopter was used extensively as one of the primary research tools available for this effort. This paper reviews the involvement of the Flight Research Laboratory of the National Research Council of Canada in the update project, it describes the various experiments conducted on the Airborne Simulator, it notes significant results obtained and describes ongoing research associated with the project.

  18. Medial Temporal Lobe Activity Predicts Successful Relational Memory Binding

    PubMed Central

    Hannula, Deborah E.; Ranganath, Charan

    2009-01-01

    Previous neuropsychological findings have implicated medial temporal lobe (MTL) structures in retaining object-location relations over the course of short delays, but MTL effects have not always been reported in neuroimaging investigations with similar short-term memory requirements. Here, we used event-related functional magnetic resonance imaging to test the hypothesis that the hippocampus and related MTL structures support accurate retention of relational memory representations, even across short delays. On every trial, four objects were presented, each in one of nine possible locations of a three-dimensional grid. Participants were to mentally rotate the grid and then maintain the rotated representation in anticipation of a test stimulus: a rendering of the grid, rotated 90° from the original viewpoint. The test stimulus was either a “match” display, in which object-location relations were intact, or a “mismatch” display, in which one object occupied a new, previously unfilled location (mismatch position), or two objects had swapped locations (mismatch swap). Encoding phase activation in anterior and posterior regions of the left hippocampus, and in bilateral perirhinal cortex, predicted subsequent accuracy on the short-term memory decision, as did bilateral posterior hippocampal activity after the test stimulus. Notably, activation in these posterior hippocampal regions was also sensitive to the degree to which object-location bindings were preserved in the test stimulus; activation was greatest for match displays, followed by mismatch-position displays, and finally mismatch-swap displays. These results indicate that the hippocampus and related MTL structures contribute to successful encoding and retrieval of relational information in visual short-term memory. PMID:18171929

  19. Medical student stories of participation in patient care-related activities: the construction of relational identity.

    PubMed

    Warmington, Sally; McColl, Geoffrey

    2017-03-01

    Professional identity formation is acknowledged as one of the fundamental tasks of contemporary medical education. Identity is a social phenomenon, constructed through participation in everyday activities and an integral part of every learning interaction. In this paper we report from an Australian ethnographic study into how medical students and patients use narrative to construct their identities. The dialogic narrative analysis employed focused on the production of meaning through the use of language devices in a given context, and the juxtaposition of multiple perspectives. Two stories told by students about their participation in patient care-related activities reveal how identities are constructed in this context through depictions of the relationships between medical students, patients and clinical teachers. These students use the rhetorical functions of stories to characterise doctors and patients in certain ways, and position themselves in relation to them. They defend common practices that circumvent valid consent processes, justified by the imperative to maximise students' participation in patient care-related activities. In doing so, they identify patients as their adversaries, and doctors as allies. Both students are influenced by others' expectations but one reveals the active nature of identity work, describing subtle acts of resistance. These stories illustrate how practices for securing students' access to patients can influence students' emerging identities, with implications for their future disclosure and consent practices. We argue that more collaborative ways of involving medical students in patient care-related activities will be facilitated if students and clinical teachers develop insight into the relational nature of identity work.

  20. Overview of EPA activities and research related to black carbon

    EPA Science Inventory

    The purpose of this international presentation is to give an overview of EPA activities related to black carbon (BC). This overview includes some summary information on how EPA defines BC, current knowledge on United States emissions and forecasted emission reductions, and ongoin...

  1. Life Cycle of the Salmon. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Tarabochia, Kathy

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  2. 12 CFR 225.131 - Activities closely related to banking.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 3 2014-01-01 2014-01-01 false Activities closely related to banking. 225.131 Section 225.131 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM (CONTINUED) BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y)...

  3. Marshes, Estuaries and Wetlands. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Marrett, Andrea

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  4. 29 CFR 780.122 - Activities relating to race horses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Activities relating to race horses. Employees engaged in the breeding, raising, and training of horses on..., attendants, exercise boys, and watchmen employed at the breeding or training farm. On the other hand... horses which have been used in commercial racing and returned to a breeding or training farm for...

  5. 29 CFR 780.122 - Activities relating to race horses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Activities relating to race horses. Employees engaged in the breeding, raising, and training of horses on..., attendants, exercise boys, and watchmen employed at the breeding or training farm. On the other hand... horses which have been used in commercial racing and returned to a breeding or training farm for...

  6. 29 CFR 780.122 - Activities relating to race horses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Activities relating to race horses. Employees engaged in the breeding, raising, and training of horses on..., attendants, exercise boys, and watchmen employed at the breeding or training farm. On the other hand... horses which have been used in commercial racing and returned to a breeding or training farm for...

  7. 29 CFR 780.122 - Activities relating to race horses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Activities relating to race horses. Employees engaged in the breeding, raising, and training of horses on..., attendants, exercise boys, and watchmen employed at the breeding or training farm. On the other hand... horses which have been used in commercial racing and returned to a breeding or training farm for...

  8. Literature and the Sea. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Katahira, Jenifer

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  9. American Poetry and the Sea. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Moore, Cecelia; Peterson, Peggy

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  10. Marine Biology Field Trip Sites. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Pauls, John

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  11. Overview of EPA activities and research related to black carbon

    EPA Science Inventory

    The purpose of this international presentation is to give an overview of EPA activities related to black carbon (BC). This overview includes some summary information on how EPA defines BC, current knowledge on United States emissions and forecasted emission reductions, and ongoin...

  12. Changes in music tempo entrain movement related brain activity.

    PubMed

    Daly, Ian; Hallowell, James; Hwang, Faustina; Kirke, Alexis; Malik, Asad; Roesch, Etienne; Weaver, James; Williams, Duncan; Miranda, Eduardo; Nasuto, Slawomir J

    2014-01-01

    The neural mechanisms of music listening and appreciation are not yet completely understood. Based on the apparent relationship between the beats per minute (tempo) of music and the desire to move (for example feet tapping) induced while listening to that music it is hypothesised that musical tempo may evoke movement related activity in the brain. Participants are instructed to listen, without moving, to a large range of musical pieces spanning a range of styles and tempos during an electroencephalogram (EEG) experiment. Event-related desynchronisation (ERD) in the EEG is observed to correlate significantly with the variance of the tempo of the musical stimuli. This suggests that the dynamics of the beat of the music may induce movement related brain activity in the motor cortex. Furthermore, significant correlations are observed between EEG activity in the alpha band over the motor cortex and the bandpower of the music in the same frequency band over time. This relationship is observed to correlate with the strength of the ERD, suggesting entrainment of motor cortical activity relates to increased ERD strength.

  13. Energy from the Sea. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Jones, Claire

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  14. Beach Profiles and Transects. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Jones, Claire

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  15. High Tide, Low Tide. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Snively, Gloria

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  16. Federal Acts Relating to Continuing Education and Public Service Activities.

    ERIC Educational Resources Information Center

    Pennsylvania State Univ., University Park. Center for Continuing Liberal Education.

    A listing is given, with brief descriptions, of Acts of Congress which relate to continuing education and public service activities. Forty-nine laws specifically authorize funds for continuing education and public service programs (Adult Education Act of 1966, Higher Education Act of 1965, Omnibus Crime Control and Safe Streets Act of 1968, Older…

  17. Face Preference in Infancy and Its Relation to Motor Activity

    ERIC Educational Resources Information Center

    Libertus, Klaus; Needham, Amy

    2014-01-01

    Infants' preference for faces was investigated in a cross-sectional sample of 75 children, aged 3 to 11 months, and 23 adults. A visual preference paradigm was used where pairs of faces and toys were presented side-by-side while eye gaze was recorded. In addition, motor activity was assessed via parent report and the relation between motor…

  18. 12 CFR 225.123 - Activities closely related to banking.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 3 2012-01-01 2012-01-01 false Activities closely related to banking. 225.123... RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial..., 1971, the Board of Governors has amended § 225.4(a) of Regulation Y to implement its regulatory...

  19. Face Preference in Infancy and Its Relation to Motor Activity

    ERIC Educational Resources Information Center

    Libertus, Klaus; Needham, Amy

    2014-01-01

    Infants' preference for faces was investigated in a cross-sectional sample of 75 children, aged 3 to 11 months, and 23 adults. A visual preference paradigm was used where pairs of faces and toys were presented side-by-side while eye gaze was recorded. In addition, motor activity was assessed via parent report and the relation between motor…

  20. The Relation between Self-Esteem, Sexual Activity, and Pregnancy.

    ERIC Educational Resources Information Center

    Robinson, Rachel B.; Frank, Deborah I.

    1994-01-01

    Examined self-esteem and sexuality in 141 male and 172 female adolescents. Found no differences in self-esteem of males versus females. Sexual activity or virginity was not related to self-esteem for either gender. Pregnant teenagers did not have different self-esteem levels from nonpregnant. Males who had fathered a child had lower self-esteem…

  1. Extraction of Children's Friendship Relation from Activity Level

    NASA Astrophysics Data System (ADS)

    Kono, Aki; Shintani, Kimio; Katsuki, Takuya; Kihara, Shin'ya; Ueda, Mari; Kaneda, Shigeo; Haga, Hirohide

    Children learn to fit into society through living in a group, and it's greatly influenced by their friend relations. Although preschool teachers need to observe them to assist in the growth of children's social progress and support the development each child's personality, only experienced teachers can watch over children while providing high-quality guidance. To resolve the problem, this paper proposes a mathematical and objective method that assists teachers with observation. It uses numerical data of activity level recorded by pedometers, and we make tree diagram called dendrogram based on hierarchical clustering with recorded activity level. Also, we calculate children's ``breadth'' and ``depth'' of friend relations by using more than one dendrogram. When we record children's activity level in a certain kindergarten for two months and evaluated the proposed method, the results usually coincide with remarks of teachers about the children.

  2. Adolescent subgenual anterior cingulate activity is related to harm avoidance

    PubMed Central

    Yang, Tony T.; Simmons, Alan N.; Matthews, Scott C.; Tapert, Susan F.; Frank, Guido K.; Bischoff-Grethe, Amanda; Lansing, Amy E.; Wu, Jing; Paulus, Martin P.

    2010-01-01

    Recent adult studies suggest that the subgenual anterior cingulate cortex (sgACC) is involved in fundamental mental operations such as affective processing and inhibitory control. However, little is known about inhibition-associated sgACC function in adolescents, and there are no published data regarding whether personality characteristics are related to inhibition-associated sgACC brain activity in adolescents. This study examined the relationship between personality and inhibition-associated sgACC response in healthy adolescents. Seventeen adolescents of 13–17 years of age underwent functional magnetic resonance imaging while performing a parametric stop-signal task. Greater harm avoidance levels were significantly associated with increased inhibition-related sgACC activity. These results establish, for the first time, a link between personality and differential sgACC activation in adolescents. PMID:19034055

  3. Immobilization of Aspergillus niger NRC 107 Xylanase and beta-Xylosidase, and Properties of the Immobilzed Enzymes.

    PubMed

    Abdel-Naby, M A

    1993-01-01

    Aspergillus niger NRC 107 xylanase and beta-xylosidase were immobilized on various carriers by different methods of immobilization, including physical absorption, covalent binding, ionic binding, and entrapment. The immobilized enzymes were prepared by physical adsorption on tannin-chitosan, ionic binding onto Dowex-50W, covalent binding on chitosan beads through glutaraldehyde, and entrapment in polyacrylamide had the highest activities. In most cases, the optimum pH of the immobilized enzymes were shifted to lower than those of free enzymes. The optimum reaction temperature of immobilized xylanase was shifted from 50C to 52.5-65C, whereas that of immobilized beta-xylosidase was shifted from 45C to 50-60C. The Km values of immobilized enzymes were higher than those of native enzymes. The operational stability of the immobilized enzymes was evaluated in continuous operation in packed-bead column-type reactors. The enzymes covalently bounded to chitosan showed the highest operational stability. However, the enzymes immobilized by physical absorption or by ionic binding showed a low operational stability. The enzymes entrapped in polyacrylamide exhibited lower activity, but better operational stability.

  4. Sociodemographic moderators of relations of neighborhood safety to physical activity.

    PubMed

    Carlson, Jordan A; Bracy, Nicole L; Sallis, James F; Millstein, Rachel A; Saelens, Brian E; Kerr, Jacqueline; Conway, Terry L; Frank, Lawrence D; Cain, Kelli L; King, Abby C

    2014-08-01

    This study aimed to investigate gender, race/ethnicity, education, and income as moderators of relations of perceived neighborhood crime, pedestrian, and traffic safety to physical activity. Participants were from two samples: adults (N = 2199, age = 25-65 yr) and older adults (N = 718, age = 66+ yr) from high- and low-walkable neighborhoods in the Washington, DC, and Seattle, Washington, areas. Neighborhood safety and transportation and leisure walking were assessed via survey, and moderate to vigorous physical activity was assessed using accelerometers. Sociodemographic moderators were investigated using interaction terms and follow-up within-group tests from mixed-effects regression models. Overall direct effects of safety on physical activity were not found, with one exception. Seven interactions were found in each sample. Interactions were found for all physical activity outcomes, although total moderate to vigorous physical activity was involved in more interactions in adults than older adults. Half of the interactions revealed significant positive relations of pedestrian and traffic safety to physical activity in the more affluent/advantaged group (i.e., high education, high income, and non-Hispanic white) and null associations in the less affluent/advantaged group. Race/ethnicity was a moderator only in older adults. One-third of the interactions involved gender; half of these involved crime safety. Interactions involving crime safety showed nonsignificant positive trends in the more affluent/advantaged group and women and nonsignificant negative trends in the less affluent/advantaged group and men. Sociodemographic moderators of neighborhood safety explained some of the variation in adults' and older adults' physical activity. Patterns suggested positive associations between safety and physical activity in participants with more affluent/advantaged sociodemographic characteristics, although some patterns were inconsistent, particularly for gender. More

  5. Update of the BIPM comparison BIPM.RI(II)-K1.Co-60 of activity measurements of the radionuclide 60Co to include the 2011 result of the CNEA (Argentina), the 2012 results of the BARC (India) and the NRC (Canada), and the 2014 result of the NIM (China)

    NASA Astrophysics Data System (ADS)

    Michotte, C.; Ratel, G.; Courte, S.; Arenillas, P.; Balpardo, C.; Joseph, L.; Anuradha, R.; Kulkarni, D. B.; Galea, R.; Moore, K.; Stroak, A.; Zhang, Ming; Liang, Juncheng; Liu, Haoran

    2017-01-01

    Since 2010, four national metrology institutes (NMI) have each submitted a sample of known activity of 60Co to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Co-60. The values of the activity submitted were between about 175 kBq and 1600 kBq. The primary standardization results for the CNEA, Argentina and the BARC, India replace their earlier result of 2003 and 2001, respectively. There are now seventeen results in the BIPM.RI(II)-K1.Co-60 comparison. The key comparison reference value (KCRV) has been updated using the power-moderated weighted mean. The degrees of equivalence between each equivalent activity measured in the SIR and the KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  6. Vibrio psychroerythrus sp. n.: Classification of the Psychrophilic Marine Bacterium, NRC 1004

    PubMed Central

    D'aoust, J. Y.; Kushner, D. J.

    1972-01-01

    A red-pigmented organism, formerly known as marine psychrophile NRC 1004, has been classified as Vibrio psychroerythrus sp. n. Classification was mainly based on morphology, the ability of the organism to oxidize and ferment glucose, its sensitivity to vibriostat 0/129, and its deoxyribonucleic acid base composition of 40.0 moles% guanine plus cytosine, determined by thermal denaturation. The organism gave positive reactions for catalase, oxidase, and starch hydrolysis and produced acid from maltose and dextrin but not from arabinose. It was indole- and citrate-negative and reduced nitrate to nitrite without producing gas. PMID:5053463

  7. Proceedings of the 24. DOE/NRC nuclear air cleaning and treatment conference

    SciTech Connect

    First, M.W.

    1997-08-01

    This report contains the papers presented at the 24th DOE/NRC Nuclear Air Cleaning and Treatment Conference and the associated discussions. Major topics are: (1) nuclear air cleaning issues, (2) waste management, (3) instrumentation and measurement, (4) testing air and gas cleaning systems, (5) progress and challenges in cleaning up Hanford, (6) international nuclear programs, (7) standardized test methods, (8) HVAC, (9) decommissioning, (10) computer modeling applications, (11) adsorption, (12) iodine treatment, (13) filters, and (14) codes and standards for filters and adsorbers. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

  8. ToxCast: One Step in the NRC Vision of 21st Century ...

    EPA Pesticide Factsheets

    The international community needs better predictive tools for assessing the hazards and risks of chemicals. It is technically feasible to collect bioactivity data on virtually all chemicals of potential concern ToxCast is providing a proof of concept for obtaining predictive, broad-based spectra of bioactivity. A critical need remains the elucidation of the majority of key biological processes involved in toxic responses Developmental toxicity represents one of the greatest challenges in this regard. ToxCast: One Step in the NRC Vision of 21st Century Toxicology

  9. ToxCast: One Step in the NRC Vision of 21st Century ...

    EPA Pesticide Factsheets

    The international community needs better predictive tools for assessing the hazards and risks of chemicals. It is technically feasible to collect bioactivity data on virtually all chemicals of potential concern ToxCast is providing a proof of concept for obtaining predictive, broad-based spectra of bioactivity. A critical need remains the elucidation of the majority of key biological processes involved in toxic responses Developmental toxicity represents one of the greatest challenges in this regard. ToxCast: One Step in the NRC Vision of 21st Century Toxicology (S)

  10. ToxCast: One Step in the NRC Vision of 21st Century ...

    EPA Pesticide Factsheets

    The international community needs better predictive tools for assessing the hazards and risks of chemicals. It is technically feasible to collect bioactivity data on virtually all chemicals of potential concern ToxCast is providing a proof of concept for obtaining predictive, broad-based spectra of bioactivity. A critical need remains the elucidation of the majority of key biological processes involved in toxic responses Developmental toxicity represents one of the greatest challenges in this regard. ToxCast: One Step in the NRC Vision of 21st Century Toxicology (T)

  11. Reassessment of biases in predicted nitrogen flows to the duodenum by NRC 2001.

    PubMed

    St-Pierre, N R

    2003-01-01

    The appearance of numerous plots in recent literature from which the residuals are plotted against observed values (Y) to assess a model's potential bias raises this question: should residuals be regressed against Y or against predicted values (Y)? The answer requires knowing the expected relationship under the assumption of an unbiased model. The objectives of this paper are: 1) to derive the expected relationship between residuals, Y, and Y; 2) to determine whether Y or Y should be used for the assessment of bias; and 3) to reassess the extent of mean and linear bias in the prediction of N flows to the duodenum by the NRC (2001). In the simplest case, we can assume a true model of the form Y = Xbeta + epsilon. This model is estimated by Y = Xb + e, and Y = Xb. The correlation between the residual vector e and the vector of observations Y can easily be derived. The numerator of the correlation coefficient is shown to be equal to e'e, the residual sum of squares. The denominator of this correlation is equal to the square root of e'e multiplied by the total sum of squares. Algebraic simplifications show that the correlation between e and Y is equal to the square root of (1-R2). That is, under the assumption of an unbiased model, the residuals are correlated with the observed values and the slope of e regressed on Y is equal to (1-R2). Thus, a graph of e versus Y will show a positive slope between e and Y unless the model is a perfect predictor (i.e., R2 is equal to 1.0). Significant slopes linking e to Y have been erroneously interpreted as evidence of biased models in the NRC (2001). Conversely, the slope of e regressed on Y is expected to be zero under the assumption of an unbiased model. Therefore, residuals should be regressed against Y and not Y. When Y, as opposed to Y, was used to assess biases in the prediction of flows to the duodenum of microbial N, nonammonia-nonmicrobial N and nonammonia N in NRC (2001), mean biases became nonsignificant and linear

  12. Evaluation of the passage rate equations in the 2001 Dairy NRC model.

    PubMed

    Seo, S; Tedeschi, L O; Schwab, C G; Garthwaite, B D; Fox, D G

    2006-06-01

    Dairy ration formulation to meet protein and amino acid requirements with the National Research Council Nutrient Requirements of Dairy Cattle (NRC, 2001) model depends on accuracy of predicting feed passage rates out of the rumen. The NRC (2001) passage rate (Kp) equations were evaluated for validity and sensitivity to input variables in predicting supplies of rumen degraded protein, rumen undegraded protein, and metabolizable protein. The database used in the development of the 3 Kp equations (for dry forage, wet forage, and concentrate) was used to independently derive the 3 equations using a meta-analysis technique. To extract quantitative relationships between statistically significant input variables and rate of passage, a random coefficients model that used each study effect as a random variable was used. The database was comprised of studies that only used rare earth markers. Outliers were identified by acceptance criteria defined a priori or the difference in fit statistic (DFFITS) value; 319, 63, and 139 treatment means were used to develop the Kp equations for dry forage, wet forage, and concentrate, respectively. We found that the sign of the regression coefficient for concentrate content in diet dry matter in the equation for Kp dry forage was inverted; it should be positive. A sensitivity analysis was conducted with a spreadsheet version of the NRC (2001) model developed for this study, using the Monte Carlo technique. The sensitivity analysis indicated that all Kp predictions were the most sensitive to variation in DM intake, and thus accurate measurement of DM intake is the most important factor in predicting Kp. Predictions for protein supply (rumen degraded protein, rumen undegraded protein, and metabolizable protein) were sensitive to variability in amount of feed crude protein (CP, %DM), digestion rate (Kd) of the B fraction of feed CP (%/h), and the Kp for concentrate (%/h), due to the high proportion of dietary CP in lactating dairy rations

  13. Comparison of (14)C liquid scintillation counting at NIST and NRC Canada.

    PubMed

    Bergeron, Denis E; Galea, Raphael; Laureano-Pérez, Lizbeth; Zimmerman, Brian E

    2016-03-01

    An informal bilateral comparison of (14)C liquid scintillation (LS) counting at the National Research Council of Canada (NRC) and the National Institute of Standards and Technology (NIST) has been completed. Two solutions, one containing (14)C-labeled sodium benzoate and one containing (14)C-labeled n-hexadecane, were measured at both laboratories. Despite observed LS cocktail instabilities, the two laboratories achieved accord in their standardizations of both solutions. At the conclusion of the comparison, the beta spectrum used for efficiency calculations was identified as inadequate and the data were reanalyzed with different inputs, improving accord. Published by Elsevier Ltd.

  14. Comparison of C-14 liquid scintillation counting at NIST and NRC Canada

    PubMed Central

    Bergeron, Denis E.; Galea, Raphael; Laureano-Pérez, Lizbeth; Zimmerman, Brian E.

    2016-01-01

    An informal bilateral comparison of 14C liquid scintillation (LS) counting at the National Research Council of Canada (NRC) and the National Institute of Standards and Technology (NIST) has been completed. Two solutions, one containing 14C-labeled sodium benzoate and one containing 14C-labeled n-hexadecane, were measured at both laboratories. Despite observed LS cocktail instabilities, the two laboratories achieved accord in their standardizations of both solutions. At the conclusion of the comparison, the beta spectrum used for efficiency calculations was identified as inadequate and the data were reanalyzed with different inputs, improving accord. PMID:26585641

  15. Relative humidity and activity patterns of Ixodes scapularis (Acari: Ixodidae)

    USGS Publications Warehouse

    Berger, K.A.; Ginsberg, Howard S.; Gonzalez, L.; Mather, T.N.

    2014-01-01

    Laboratory studies have shown clear relationships between relative humidity (RH) and the activity and survival of Ixodes scapularis Say (blacklegged tick). However, field studies have produced conflicting results. We examined this relationship using weekly tick count totals and hourly RH observations at three field sites, stratified by latitude, within the state of Rhode Island. Records of nymphal tick abundance were compared with several RH-related variables (e.g., RH at time of sampling and mean weekly daytime RH). In total, 825 nymphs were sampled in 2009, a year of greater precipitation, with a weighted average leaf litter RH recorded at time of sampling of 85.22%. Alternatively, 649 nymphs were collected in 2010, a year of relatively low precipitation, and a weighted average RH recorded at time of sampling was 75.51%. Negative binomial regression analysis of tick count totals identified cumulative hours <82% RH threshold as a significant factor observed in both years (2009: P = 0.0037; 2010: P < 0.0001). Mean weekly daytime RH did not significantly predict tick activity in either year. However, mean weekly daytime RH recorded with 1-wk lag before sample date was a significant variable (P = 0.0016) in 2010. These results suggest a lag effect between moisture availability and patterns of tick activity and abundance. Differences in the relative importance of each RH variable between years may have been due to abnormally wet summer conditions in 2009.

  16. Positive mood enhances reward-related neural activity

    PubMed Central

    Nusslock, Robin

    2016-01-01

    Although behavioral research has shown that positive mood leads to desired outcomes in nearly every major life domain, no studies have directly examined the effects of positive mood on the neural processes underlying reward-related affect and goal-directed behavior. To address this gap, participants in the present fMRI study experienced either a positive (n = 20) or neutral (n = 20) mood induction and subsequently completed a monetary incentive delay task that assessed reward and loss processing. Consistent with prediction, positive mood elevated activity specifically during reward anticipation in corticostriatal neural regions that have been implicated in reward processing and goal-directed behavior, including the nucleus accumbens, caudate, lateral orbitofrontal cortex and putamen, as well as related paralimbic regions, including the anterior insula and ventromedial prefrontal cortex. These effects were not observed during reward outcome, loss anticipation or loss outcome. Critically, this is the first study to report that positive mood enhances reward-related neural activity. Our findings have implications for uncovering the neural mechanisms by which positive mood enhances goal-directed behavior, understanding the malleability of reward-related neural activity, and developing targeted treatments for psychiatric disorders characterized by deficits in reward processing. PMID:26833919

  17. A Survey of Health-Related Activities on Second Life

    PubMed Central

    Beard, Leslie; Wilson, Kumanan; Morra, Dante

    2009-01-01

    Background Increasingly, governments, health care agencies, companies, and private groups have chosen Second Life as part of their Web 2.0 communication strategies. Second Life offers unique design features for disseminating health information, training health professionals, and enabling patient education for both academic and commercial health behavior research. Objectives This study aimed to survey and categorize the range of health-related activities on Second Life; to examine the design attributes of the most innovative and popular sites; and to assess the potential utility of Second Life for the dissemination of health information and for health behavior change. Methods We used three separate search strategies to identify health-related sites on Second Life. The first used the application’s search engine, entering both generic and select illness-specific keywords, to seek out sites. The second identified sites through a comprehensive review of print, blog, and media sources discussing health activities on Second Life. We then visited each site and used a snowball method to identify other health sites until we reached saturation (no new health sites were identified). The content, user experience, and chief purpose of each site were tabulated as well as basic site information, including user traffic data and site size. Results We found a wide range of health-related activities on Second Life, and a diverse group of users, including organizations, groups, and individuals. For many users, Second Life activities are a part of their Web 2.0 communication strategy. The most common type of health-related site in our sample (n = 68) were those whose principle aim was patient education or to increase awareness about health issues. The second most common type of site were support sites, followed by training sites, and marketing sites. Finally, a few sites were purpose-built to conduct research in SL or to recruit participants for real-life research. Conclusions Studies

  18. Online Activity Levels Are Related to Caffeine Dependency.

    PubMed

    Phillips, James G; Landhuis, C Erik; Shepherd, Daniel; Ogeil, Rowan P

    2016-05-01

    Online activity could serve in the future as behavioral markers of emotional states for computer systems (i.e., affective computing). Hence, this study considered relationships between self-reported stimulant use and online study patterns. Sixty-two undergraduate psychology students estimated their daily caffeine use, and this was related to study patterns as tracked by their use of a Learning Management System (Blackboard). Caffeine dependency was associated with less time spent online, lower rates of file access, and fewer online activities completed. Reduced breadth or depth of processing during work/study could be used as a behavioral marker of stimulant use.

  19. Systemic complement activation in age-related macular degeneration.

    PubMed

    Scholl, Hendrik P N; Charbel Issa, Peter; Walier, Maja; Janzer, Stefanie; Pollok-Kopp, Beatrix; Börncke, Florian; Fritsche, Lars G; Chong, Ngaihang V; Fimmers, Rolf; Wienker, Thomas; Holz, Frank G; Weber, Bernhard H F; Oppermann, Martin

    2008-07-02

    Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of complement activation underlies AMD, parameters of complement activation in blood plasma were determined together with disease-associated genetic markers in AMD patients. Plasma concentrations of activation products C3d, Ba, C3a, C5a, SC5b-9, substrate proteins C3, C4, factor B and regulators factor H and factor D were quantified in patients (n = 112) and controls (n = 67). Subjects were analyzed for single nucleotide polymorphisms in factor H (CFH), factor B-C2 (BF-C2) and complement C3 (C3) genes which were previously found to be associated with AMD. All activation products, especially markers of chronic complement activation Ba and C3d (p<0.001), were significantly elevated in AMD patients compared to controls. Similar alterations were observed in factor D, but not in C3, C4 or factor H. Logistic regression analysis revealed better discriminative accuracy of a model that is based only on complement activation markers Ba, C3d and factor D compared to a model based on genetic markers of the complement system within our study population. In both the controls' and AMD patients' group, the protein markers of complement activation were correlated with CFH haplotypes.This study is the first to show systemic complement activation in AMD patients. This suggests that AMD is a systemic disease with local disease manifestation at the ageing macula. Furthermore, the data provide evidence for an association of systemic activation of the alternative complement pathway with genetic variants of CFH that were previously linked to AMD susceptibility.

  20. Activity cliffs and activity cliff generators based on chemotype-related activity landscapes.

    PubMed

    Pérez-Villanueva, Jaime; Méndez-Lucio, Oscar; Soria-Arteche, Olivia; Medina-Franco, José L

    2015-11-01

    Activity cliffs have large impact in drug discovery; therefore, their detection and quantification are of major importance. This work introduces the metric activity cliff enrichment factor and expands the previously reported activity cliff generator concept by adding chemotype information to representations of the activity landscape. To exemplify these concepts, three molecular databases with multiple biological activities were characterized. Compounds in each database were grouped into chemotype classes. Then, pairwise comparisons of structure similarities and activity differences were calculated for each compound and used to construct chemotype-based structure-activity similarity (SAS) maps. Different landscape distributions among four major regions of the SAS maps were observed for different subsets of molecules grouped in chemotypes. Based on this observation, the activity cliff enrichment factor was calculated to numerically detect chemotypes enriched in activity cliffs. Several chemotype classes were detected having major proportion of activity cliffs than the entire database. In addition, some chemotype classes comprising compounds with smooth structure activity relationships (SAR) were detected. Finally, the activity cliff generator concept was applied to compounds grouped in chemotypes to extract valuable SAR information.

  1. The Relation Between Instrumental Musical Activity and Cognitive Aging

    PubMed Central

    Hanna-Pladdy, Brenda; MacKay, Alicia

    2015-01-01

    Objective Intensive repetitive musical practice can lead to bilateral cortical reorganization. However, whether musical sensorimotor and cognitive abilities transfer to nonmusical cognitive abilities that are maintained throughout the life span is unclear. In an attempt to identify modifiable lifestyle factors that may potentially enhance successful aging, we evaluated the association between musical instrumental participation and cognitive aging. Method Seventy older healthy adults (ages 60–83) varying in musical activity completed a comprehensive neuropsychological battery. The groups (nonmusicians, low and high activity musicians) were matched on age, education, history of physical exercise, while musicians were matched on age of instrumental acquisition and formal years of musical training. Musicians were classified in the low (1–9 years) or high (>10 years) activity group based on years of musical experience throughout their life span. Results The results of this preliminary study revealed that participants with at least 10 years of musical experience (high activity musicians) had better performance in nonverbal memory (η2 = .106), naming (η2 = .103), and executive processes (η2 = .131) in advanced age relative to nonmusicians. Several regression analyses evaluated how years of musical activity, age of acquisition, type of musical training, and other variables predicted cognitive performance. Conclusions These correlational results suggest a strong predictive effect of high musical activity throughout the life span on preserved cognitive functioning in advanced age. A discussion of how musical participation may enhance cognitive aging is provided along with other alternative explanations. PMID:21463047

  2. The relation between instrumental musical activity and cognitive aging.

    PubMed

    Hanna-Pladdy, Brenda; MacKay, Alicia

    2011-05-01

    Intensive repetitive musical practice can lead to bilateral cortical reorganization. However, whether musical sensorimotor and cognitive abilities transfer to nonmusical cognitive abilities that are maintained throughout the life span is unclear. In an attempt to identify modifiable lifestyle factors that may potentially enhance successful aging, we evaluated the association between musical instrumental participation and cognitive aging. Seventy older healthy adults (ages 60-83) varying in musical activity completed a comprehensive neuropsychological battery. The groups (nonmusicians, low and high activity musicians) were matched on age, education, history of physical exercise, while musicians were matched on age of instrumental acquisition and formal years of musical training. Musicians were classified in the low (1-9 years) or high (>10 years) activity group based on years of musical experience throughout their life span. The results of this preliminary study revealed that participants with at least 10 years of musical experience (high activity musicians) had better performance in nonverbal memory (η2 = .106), naming (η2 = .103), and executive processes (η2 = .131) in advanced age relative to nonmusicians. Several regression analyses evaluated how years of musical activity, age of acquisition, type of musical training, and other variables predicted cognitive performance. These correlational results suggest a strong predictive effect of high musical activity throughout the life span on preserved cognitive functioning in advanced age. A discussion of how musical participation may enhance cognitive aging is provided along with other alternative explanations.

  3. Purification and characterization of the enzymes involved in nicotinamide adenine dinucleotide degradation by Penicillium brevicompactum NRC 829.

    PubMed

    Ali, Thanaa Hamed; El-Ghonemy, Dina Helmy

    2016-06-01

    The present study was conducted to investigate a new pathway for the degradation of nicotinamide adenine dinucleotide (NAD) by Penicillium brevicompactum NRC 829 extracts. Enzymes involved in the hydrolysis of NAD, i.e. alkaline phosphatase, aminohydrolase and glycohydrolase were determined. Alkaline phosphatase was found to catalyse the sequential hydrolysis of two phosphate moieties of NAD molecule to nicotinamide riboside plus adenosine. Adenosine was then deaminated by aminohydrolase to inosine and ammonia. While glycohydrolase catalyzed the hydrolysis of the nicotinamide-ribosidic bond of NAD+ to produce nicotinamide and ADP-ribose in equimolar amounts, enzyme purification through a 3-step purification procedure revealed the existence of two peaks of alkaline phosphatases, and one peak contained deaminase and glycohydrolase activities. NAD deaminase was purified to homogeneity as estimated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis with an apparent molecular mass of 91 kDa. Characterization and determination of some of NAD aminohydrolase kinetic properties were conducted due to its biological role in the regulation of cellular NAD level. The results also revealed that NAD did not exert its feedback control on nicotinamide amidase produced by P. brevicompactum.

  4. Cohort Profile: The National Academy of Sciences-National Research Council Twin Registry (NAS-NRC Twin Registry).

    PubMed

    Gatz, Margaret; Harris, Jennifer R; Kaprio, Jaakko; McGue, Matt; Smith, Nicholas L; Snieder, Harold; Spiro, Avron; Butler, David A

    2015-06-01

    The National Academy of Sciences-National Research Council Twin Registry (NAS-NRC Twin Registry) is a comprehensive registry of White male twin pairs born in the USA between 1917 and 1927, both of the twins having served in the military. The purpose was medical research and ultimately improved clinical care. The cohort was assembled in the early 1960s with identification of approximately 16,000 twin pairs, review of service records, a brief mailed questionnaire assessing zygosity, and a health survey largely comparable to questionnaires used at that time with Scandinavian twin registries. Subsequent large-scale data collection occurred in 1974, 1985 and 1998, repeating the health survey and including information on education, employment history and earnings. Self-reported data have been supplemented with mortality, disability and medical data through record linkage. Potential collaborators should access the study website [http://www.iom.edu/Activities/Veterans/TwinsStudy.aspx] or e-mail the Medical Follow-up Agency at [Twins@nas.edu]. Questionnaire data are being prepared for future archiving with the National Archive of Computerized Data on Aging (NACDA) at the Inter-University Consortium for Political and Social Research (ICPSR), University of Michigan, MI.

  5. Production of levansucrase from Bacillus subtilis NRC 33a and enzymic synthesis of levan and Fructo-Oligosaccharides.

    PubMed

    Abdel-Fattah, Ahmed F; Mahmoud, Doaa A R; Esawy, Mona A T

    2005-12-01

    Bacillus subtilis NRC 33a was able to produce both inducible and constitutive extracellular levansucrase, respectively, using sucrose and glucose as carbon source. The optimal production of the levansucrase was at 30 degrees C. The effect of different nitrogen sources showed that baker's yeast with 2% concentration gave the highest levansucrase activity. Addition of 0.15 g/L MgSO(4) was the most favorable for levansucrase production. The enzymic synthesis of levan was studied using 60% acetone fraction. The results indicated that high enzyme concentrations produced increasing amounts of levan, and hence conversion of fructose to levan reached 84% using 1,000 microg/ml enzyme protein. Sucrose concentration was the most effective factor controlling the molecular weight of the synthesized levan. The conversion of fructose to levan was maximal at 30 degrees C. The time of reaction clearly affected the conversion of fructose to levan, which reached its maximum productivity at 18 hours (92%). Identification of levan indicated that fructose was the building unit of levan.

  6. Cohort Profile: The National Academy of Sciences-National Research Council Twin Registry (NAS-NRC Twin Registry)

    PubMed Central

    Gatz, Margaret; Harris, Jennifer R; Kaprio, Jaakko; McGue, Matt; Smith, Nicholas L; Snieder, Harold; Spiro, Avron; Butler, David A

    2015-01-01

    The National Academy of Sciences-National Research Council Twin Registry (NAS-NRC Twin Registry) is a comprehensive registry of White male twin pairs born in the USA between 1917 and 1927, both of the twins having served in the military. The purpose was medical research and ultimately improved clinical care. The cohort was assembled in the early 1960s with identification of approximately 16 000 twin pairs, review of service records, a brief mailed questionnaire assessing zygosity, and a health survey largely comparable to questionnaires used at that time with Scandinavian twin registries. Subsequent large-scale data collection occurred in 1974, 1985 and 1998, repeating the health survey and including information on education, employment history and earnings. Self-reported data have been supplemented with mortality, disability and medical data through record linkage. Potential collaborators should access the study website [http://www.iom.edu/Activities/Veterans/TwinsStudy.aspx] or e-mail the Medical Follow-up Agency at [Twins@nas.edu]. Questionnaire data are being prepared for future archiving with the National Archive of Computerized Data on Aging (NACDA) at the Inter-University Consortium for Political and Social Research (ICPSR), University of Michigan, MI. PMID:25183748

  7. Relation of Biospeckle Activity with Quality Attributes of Apples

    PubMed Central

    Zdunek, Artur; Cybulska, Justyna

    2011-01-01

    Biospeckle is nondestructive optical technique based on the analysis of variations of laser light scattered from biological samples. Biospeckle activity reflects the state of the investigated object. In this study the relation of biospeckle activity (BA) with firmness, soluble solids content (SSC), titratable acidity (TA) and starch content (SC) during the shelf life of seven apple cultivars was studied. The results showed that the quality attributes change significantly during storage. Significant and pronounced positive correlation between BA and SC was found. This result shows that degradation of starch granules, which could be stimulated to vibration by intracellular cyclosis, causes a lesser number of laser light scattering centers and results in smaller apparent biospeckle activity. PMID:22163957

  8. Neuromodulation of Whisking Related Neural Activity in Superior Colliculus

    PubMed Central

    Bezdudnaya, Tatiana

    2014-01-01

    The superior colliculus is part of a broader neural network that can decode whisker movements in air and on objects, which is a strategy used by behaving rats to sense the environment. The intermediate layers of the superior colliculus receive whisker-related excitatory afferents from the trigeminal complex and barrel cortex, inhibitory afferents from extrinsic and intrinsic sources, and neuromodulatory afferents from cholinergic and monoaminergic nuclei. However, it is not well known how these inputs regulate whisker-related activity in the superior colliculus. We found that barrel cortex afferents drive the superior colliculus during the middle portion of the rising phase of the whisker movement protraction elicited by artificial (fictive) whisking in anesthetized rats. In addition, both spontaneous and whisker-related neural activities in the superior colliculus are under strong inhibitory and neuromodulator control. Cholinergic stimulation activates the superior colliculus by increasing spontaneous firing and, in some cells, whisker-evoked responses. Monoaminergic stimulation has the opposite effects. The actions of neuromodulator and inhibitory afferents may be the basis of the different firing rates and sensory responsiveness observed in the superior colliculus of behaving animals during distinct behavioral states. PMID:24872572

  9. Transit-Related Walking to Work in Promoting Physical Activity.

    PubMed

    Yu, Chia-Yuan; Lin, Hsien-Chang

    2015-04-01

    Transit-related walking to work is a potential strategy for incorporating physical activity into daily life and promoting health benefits. This study estimated the transit-related walking time for work trips on the journey to and from work and examined the predictors of transit users who walked to/from transit and the workplace and those who walked 30 minutes or more per day. This study used the 2009 National Household Travel Survey and identified 772 subjects who took transit to/from work, 355 subjects who walked to/from transit and the workplace, and 145 subjects who walked 30 minutes or more per day among the 40,659 workers. Weighted logistic regressions were used for the analysis. Of the people who walked to/from transit and the workplace, 40.9% walked 30 minutes or more per day. The weighted logistic regressions revealed that low-income groups and workers living in high population density areas were more likely to walk to/from transit and the workplace. Workers living in high population density areas were more likely to walk 30 minutes or more per day. Transit-related walking to work provides an opportunity to increase physical activity levels and to meet the physical activity recommendations.

  10. [Sports practice is related to parasympathetic activity in adolescents].

    PubMed

    Cayres, Suziane Ungari; Vanderlei, Luiz Carlos Marques; Rodrigues, Aristides Machado; Silva, Manuel João Coelho E; Codogno, Jamile Sanches; Barbosa, Maurício Fregonesi; Fernandes, Rômulo Araújo

    2015-01-01

    To analyze the relationship among sports practice, physical education class, habitual physical activity and cardiovascular risk in adolescents. Cross-sectional study with 120 schoolchildren (mean: 11.7±0.7 years old), with no regular use of medicines. Sports practice and physical education classes were assessed through face-to-face interview, while habitual physical activity was assessed by pedometers. Body weight, height and height-cephalic trunk were used to estimate maturation. The following variables were measured: body fatness, blood pressure, resting heart rate, blood flow velocity, intima-media thickness (carotid and femoral) and heart rate variability (mean between consecutive heartbeats and statistical index in the time domain that show the autonomic parasympathetic nervous system activity root-mean by the square of differences between adjacent normal R-R intervals in a time interval. Statistical treatment used Spearman correlation adjusted by sex, ethnicity, age, body fatness and maturation. Independently of potential confounders, sports practice was positively related to autonomic parasympathetic nervous system activity (β=0.039 [0.01; 0.76]). On the other hand, the relationship between sport practice and mean between consecutive heartbeats (β=0,031 [-0.01; 0.07]) was significantly mediated by biological maturation. Sport practice was related to higher heart rate variability at rest. Copyright © 2015 Associação de Pediatria de São Paulo. Publicado por Elsevier Editora Ltda. All rights reserved.

  11. Exercising self-control increases relative left frontal cortical activation.

    PubMed

    Schmeichel, Brandon J; Crowell, Adrienne; Harmon-Jones, Eddie

    2016-02-01

    Self-control refers to the capacity to override or alter a predominant response tendency. The current experiment tested the hypothesis that exercising self-control temporarily increases approach motivation, as revealed by patterns of electrical activity in the prefrontal cortex. Participants completed a writing task that did vs did not require them to exercise self-control. Then they viewed pictures known to evoke positive, negative or neutral affect. We assessed electroencephalographic (EEG) activity while participants viewed the pictures, and participants reported their trait levels of behavioral inhibition system (BIS) and behavioral activation system (BAS) sensitivity at the end of the study. We found that exercising (vs not exercising) self-control increased relative left frontal cortical activity during picture viewing, particularly among individuals with relatively higher BAS than BIS, and particularly during positive picture viewing. A similar but weaker pattern emerged during negative picture viewing. The results suggest that exercising self-control temporarily increases approach motivation, which may help to explain the aftereffects of self-control (i.e. ego depletion).

  12. Sports practice is related to parasympathetic activity in adolescents

    PubMed Central

    Cayres, Suziane Ungari; Vanderlei, Luiz Carlos Marques; Rodrigues, Aristides Machado; Coelho e Silva, Manuel João; Codogno, Jamile Sanches; Barbosa, Maurício Fregonesi; Fernandes, Rômulo Araújo

    2015-01-01

    OBJECTIVE: To analyze the relationship among sports practice, physical education class, habitual physical activity and cardiovascular risk in adolescents. METHODS: Cross-sectional study with 120 schoolchildren (mean: 11.7±0.7 years old), with no regular use of medicines. Sports practice and physical education classes were assessed through face-to-face interview, while habitual physical activity was assessed by pedometers. Bodyweight, height and height-cephalic trunk were used to estimate maturation. The following variables were measured: body fatness, blood pressure, resting heart rate, blood flow velocity, intima-media thickness (carotid and femoral) and heart rate variability (mean between consecutive heartbeats and statistical index in the time domain that show the autonomic parasympathetic nervous system activity root-mean by the square of differences between adjacent normal R-R intervals in a time interval). Statistical treatment used Spearman correlation adjusted by sex, ethnicity, age, body fatness and maturation. RESULTS: Independently of potential confounders, sports practice was positively related to autonomic parasympathetic nervous system activity (β=0.039 [0.01; 0.76]). On the other hand, the relationship between sport practice and mean between consecutive heartbeats (β=0,031 [-0.01; 0.07]) was significantly mediated by biological maturation. CONCLUSIONS: Sport practice was related to higher heart rate variability at rest. PMID:25887927

  13. Diet quality and physical activity in relation to childhood obesity.

    PubMed

    An, Ruopeng

    2017-04-01

    Healthy lifestyles such as being physically active and eating a healthy diet help reduce the childhood obesity risk. However, population-level studies on the relationship between lifestyles and childhood obesity typically focus on either physical activity or diet but seldom both. This study examined physical activity and diet quality in relation to obesity in a nationally representative sample of U.S. children and adolescents. The study sample of 2818 children 6-17 years old came from the National Health and Nutrition Examination Survey 2003-2006 waves. A healthy eating index (HEI)-2010 was constructed based on two nonconsecutive 24-h dietary recalls. Participants at or above the 60th percentile of the HEI-2010 score were classified as consuming a healthy diet. Participants engaging in at least 60 min of moderate-vigorous physical activity daily measured by accelerometer were classified as being physically active. Adjusted average marginal effect of diet quality and physical activity on obesity was calculated based on estimates from logistic regressions. Compared with those consuming a healthy diet who are physically active, the estimated probabilities for overweight and obesity were 19.03 (95% confidence interval: 11.31, 26.74) and 15.84 (10.48, 21.21) percentage points higher among children consuming an unhealthy diet and who are physically inactive, 16.53 (7.58, 25.48) and 13.48 (5.68, 21.29) percentage points higher among children consuming a healthy diet but who are physically inactive and 3.22 (-3.43, 9.88) and 3.10 (-3.08, 9.29) percentage points higher among children consuming an unhealthy diet but physically active, respectively. Healthy habit formation at an early age is essential in obesity prevention.

  14. The rotation-activity relation in M dwarfs

    NASA Astrophysics Data System (ADS)

    Newton, Elisabeth R.; Irwin, Jonathan; Charbonneau, David; Berlind, Perry L.; Calkins, Michael L.; Mink, Jessica D.

    2017-01-01

    Main sequence stars with masses below approximately 0.35 solar masses are fully-convective, and are expected to have a different type of magnetic dynamo than solar-type stars. Observationally, the dynamo mechanism can be probed through the relationship between rotation and magnetic activity, and the evolution of these properties. Though M dwarfs are the most common type of star in the galaxy, a lack of observational constraints at ages beyond 1 Gyr has hampered studies of the rotation-activity relation. To address this, we have made new measurements of rotation and magnetic activity in nearby, field-age M dwarfs. Combining our 386 rotation period measurements and 247 new optical spectra with data from the literature, we are able to probe the rotation-activity in M dwarfs with masses from 0.1 to 0.6 solar masses. We observe a threshold in the mass--period plane that separates active and inactive M dwarfs. The threshold coincides with the fast-period edge of the slowly rotating population, at approximately the rotation period at which an era of rapid rotational evolution appears to cease. We confirm that the activity of rapidly rotating M dwarfs maintains a saturated value. We have measured rotation periods as long as 140 days, allowing us to probe the unsaturated regime in detail. Our data show a clear power-law decay in relative H-alpha luminosity as a function Rossby number. We discuss implications for the magnetic dynamo mechanism.We acknowledge funding from the National Science Foundation, the David and Lucile Packard Foundation Fellowship for Science and Engineering, and the John Templeton Foundation. E.R.N. acknowledges support from the NSF through a Graduate Research Fellowship and an Astronomy and Astrophysics Postdoctoral Fellowship.

  15. The NRC/SNL (Nuclear Regulatory Commission)/(Sandia National Laboratory) performance assessment methodology for low-level radioactive waste facilities

    SciTech Connect

    Kozak, M.W.

    1991-01-01

    A performance assessment methodology has been developed for use by the US Nuclear Regulatory Commission (NRC) in evaluating license applications for low-level waste disposal facilities. This paper provides a summary of the modeling approaches selected for the methodology, and includes discussions of the philosophy and structure of the methodology. The performance assessment methodology is designed to provide the NRC with a tool for performing confirmatory analyses in support of license reviews related to postclosure performance. The methodology allows analyses of dose to individuals from off-site releases under normal conditions as well as on-site doses to inadvertent intruders. Computer codes have been chosen for source-term analysis, for vadose-zone flow and transport, for saturated-zone flow and transport, for surface-water transport, for transport via the air pathway, and for food chain and dosimetry analyses. More than one computer code is recommended for each module in the methodology, which increases its flexibility, but also increases the amount of user effort required to provide interfaces between the modules. 25 refs., 2 figs.

  16. Children's Perceptions of Mood-Related Activities: Development of the Pleasant and Unpleasant Activities Surveys.

    ERIC Educational Resources Information Center

    Wierzbicki, Michael

    P. M. Lewinsohn has theorized that depression is related to the amount of positive reinforcement that an individual receives. Lewinsohn has supported this model in adults by showing that depression is correlated with an increase in unpleasant activities and a decrease in pleasant activities. This study extended Lewinsohn's model by developing…

  17. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1.

    PubMed

    Garapaty, Shivani; Mahajan, Muktar A; Samuels, Herbert H

    2008-03-14

    CCR4-NOT is an evolutionarily conserved, multicomponent complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1 and CNOT7/CAF1) have been reported to be involved in influencing nuclear hormone receptor activities. Here, we show that CCR4/CNOT6 and RCD1/CNOT9, members of the CCR4-NOT complex, potentiate nuclear receptor activity. RCD1 interacts in vivo and in vitro with NIF-1 (NRC-interacting factor), a previously characterized nuclear receptor cotransducer that activates nuclear receptors via its interaction with NRC. As with NIF-1, RCD1 and CCR4 do not directly associate with nuclear receptors; however, they enhance ligand-dependent transcriptional activation by nuclear hormone receptors. CCR4 mediates its effect through the ligand binding domain of nuclear receptors and small interference RNA-mediated silencing of endogenous CCR4 results in a marked decrease in nuclear receptor activation. Furthermore, knockdown of CCR4 results in an attenuated stimulation of RARalpha target genes (e.g. Sox9 and HoxA1) as shown by quantitative PCR assays. The silencing of endogenous NIF-1 also resulted in a comparable decrease in the RAR-mediated induction of both Sox9 and HoxA1. Furthermore, CCR4 associates in vivo with NIF-1. In addition, the CCR4-enhanced transcriptional activation by nuclear receptors is dependent on NIF-1. The small interference RNA-mediated knockdown of NIF-1 blocks the ligand-dependent potentiating effect of CCR4. Our results suggest that CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and that RCD1 and CCR4 might mediate their function through their interaction with NIF-1.

  18. Diverse Expected Gradient Active Learning for Relative Attributes.

    PubMed

    You, Xinge; Wang, Ruxin; Tao, Dacheng

    2014-06-02

    The use of relative attributes for semantic understanding of images and videos is a promising way to improve communication between humans and machines. However, it is extremely labor- and time-consuming to define multiple attributes for each instance in large amount of data. One option is to incorporate active learning, so that the informative samples can be actively discovered and then labeled. However, most existing active-learning methods select samples one at a time (serial mode), and may therefore lose efficiency when learning multiple attributes. In this paper, we propose a batch-mode active-learning method, called Diverse Expected Gradient Active Learning (DEGAL). This method integrates an informativeness analysis and a diversity analysis to form a diverse batch of queries. Specifically, the informativeness analysis employs the expected pairwise gradient length as a measure of informativeness, while the diversity analysis forces a constraint on the proposed diverse gradient angle. Since simultaneous optimization of these two parts is intractable, we utilize a two-step procedure to obtain the diverse batch of queries. A heuristic method is also introduced to suppress imbalanced multi-class distributions. Empirical evaluations of three different databases demonstrate the effectiveness and efficiency of the proposed approach.

  19. Diverse expected gradient active learning for relative attributes.

    PubMed

    You, Xinge; Wang, Ruxin; Tao, Dacheng

    2014-07-01

    The use of relative attributes for semantic understanding of images and videos is a promising way to improve communication between humans and machines. However, it is extremely labor- and time-consuming to define multiple attributes for each instance in large amount of data. One option is to incorporate active learning, so that the informative samples can be actively discovered and then labeled. However, most existing active-learning methods select samples one at a time (serial mode), and may therefore lose efficiency when learning multiple attributes. In this paper, we propose a batch-mode active-learning method, called diverse expected gradient active learning. This method integrates an informativeness analysis and a diversity analysis to form a diverse batch of queries. Specifically, the informativeness analysis employs the expected pairwise gradient length as a measure of informativeness, while the diversity analysis forces a constraint on the proposed diverse gradient angle. Since simultaneous optimization of these two parts is intractable, we utilize a two-step procedure to obtain the diverse batch of queries. A heuristic method is also introduced to suppress imbalanced multiclass distributions. Empirical evaluations of three different databases demonstrate the effectiveness and efficiency of the proposed approach.

  20. The Necessity of Public Relations for Sustainable Mining Activities

    NASA Astrophysics Data System (ADS)

    Lee, Hyunbock; Ji, Sangwoo

    2015-04-01

    other hand, in the survey to determine what the greatest difficulties of the current mining activities, 54% of mining companies chose environmental regulations, 26% of mining companies chose conflicts between mine area residents and mining companies. Environmental regulations are may defined as the greatest difficulty of current mining activities. But most of environmental regulation's problems are caused by frictions with residents, because all of South Korean mines are very close to villages. So, the biggest difficulty of mining activities can be defined conflicts between residents and mining companies. Moreover, general people in South Korea including some mining engineers recognize the mining industry as a declined and pollution industry. Without clear understanding of mining activities, any mine developments and policies related to mining activities cannot be made by rational discussions. And, if their recognition is not formed in a rational way, it will be turned to extreme fear or blind hatred. Therefore, to understand mining activities correctly, the effective public relations strategy is necessary such as corporate advertisements or public advertisements.

  1. Age-related differences in brain network activation and co-activation during multiple object tracking.

    PubMed

    Dørum, Erlend S; Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviève; Lund, Martina J; Tønnesen, Siren; Sneve, Markus H; Mathiesen, Nina C; Rustan, Øyvind G; Gjertsen, Øivind; Vatn, Sigurd; Fure, Brynjar; Andreassen, Ole A; Nordvik, Jan Egil; Westlye, Lars T

    2016-11-01

    Multiple object tracking (MOT) is a powerful paradigm for measuring sustained attention. Although previous fMRI studies have delineated the brain activation patterns associated with tracking and documented reduced tracking performance in aging, age-related effects on brain activation during MOT have not been characterized. In particular, it is unclear if the task-related activation of different brain networks is correlated, and also if this coordination between activations within brain networks shows differential effects of age. We obtained fMRI data during MOT at two load conditions from a group of younger (n = 25, mean age = 24.4 ± 5.1 years) and older (n = 21, mean age = 64.7 ± 7.4 years) healthy adults. Using a combination of voxel-wise and independent component analysis, we investigated age-related differences in the brain network activation. In order to explore to which degree activation of the various brain networks reflect unique and common mechanisms, we assessed the correlations between the brain networks' activations. Behavioral performance revealed an age-related reduction in MOT accuracy. Voxel and brain network level analyses converged on decreased load-dependent activations of the dorsal attention network (DAN) and decreased load-dependent deactivations of the default mode networks (DMN) in the old group. Lastly, we found stronger correlations in the task-related activations within DAN and within DMN components for younger adults, and stronger correlations between DAN and DMN components for older adults. Using MOT as means for measuring attentional performance, we have demonstrated an age-related attentional decline. Network-level analysis revealed age-related alterations in network recruitment consisting of diminished activations of DAN and diminished deactivations of DMN in older relative to younger adults. We found stronger correlations within DMN and within DAN components for younger adults and stronger correlations between DAN

  2. Medicinal plant activity on Helicobacter pylori related diseases

    PubMed Central

    Wang, Yuan-Chuen

    2014-01-01

    More than 50% of the world population is infected with Helicobacter pylori (H. pylori). The bacterium highly links to peptic ulcer diseases and duodenal ulcer, which was classified as a group I carcinogen in 1994 by the WHO. The pathogenesis of H. pylori is contributed by its virulence factors including urease, flagella, vacuolating cytotoxin A (VacA), cytotoxin-associated gene antigen (Cag A), and others. Of those virulence factors, VacA and CagA play the key roles. Infection with H. pylori vacA-positive strains can lead to vacuolation and apoptosis, whereas infection with cagA-positive strains might result in severe gastric inflammation and gastric cancer. Numerous medicinal plants have been reported for their anti-H. pylori activity, and the relevant active compounds including polyphenols, flavonoids, quinones, coumarins, terpenoids, and alkaloids have been studied. The anti-H. pylori action mechanisms, including inhibition of enzymatic (urease, DNA gyrase, dihydrofolate reductase, N-acetyltransferase, and myeloperoxidase) and adhesive activities, high redox potential, and hydrophilic/hydrophobic natures of compounds, have also been discussed in detail. H. pylori-induced gastric inflammation may progress to superficial gastritis, atrophic gastritis, and finally gastric cancer. Many natural products have anti-H. pylori-induced inflammation activity and the relevant mechanisms include suppression of nuclear factor-κB and mitogen-activated protein kinase pathway activation and inhibition of oxidative stress. Anti-H. pylori induced gastric inflammatory effects of plant products, including quercetin, apigenin, carotenoids-rich algae, tea product, garlic extract, apple peel polyphenol, and finger-root extract, have been documented. In conclusion, many medicinal plant products possess anti-H. pylori activity as well as an anti-H. pylori-induced gastric inflammatory effect. Those plant products have showed great potential as pharmaceutical candidates for H. pylori

  3. [Estrogenic activity of ultraviolet absorbers and the related compounds].

    PubMed

    Matsumoto, Hisashi; Adachi, Shinichi; Suzuki, Yasuhiko

    2005-08-01

    The estrogenic activities of ultraviolet absorbers and their related compounds were investigated using MCF-7 cell proliferation assay. Nine of 33 chemicals (benzophenone, 2,4-dihydroxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 4-hydroxybenzophenone, 3-(4-methylbenzylidene) camphor, ethyl 2-cyano-3,3-diphenylacrylate (etocrylene) and 2-ethylhexyl-2-cyano-3,3-diphenylacrylate (octocrylene)) were positive compared with the vehicle control. Benzhydrol, ethyl cinnamate and 2,2'-dihydroxy-4-methoxybenzophenone were weakly active. When each xenoestrogen was added to the cells along with ICI 182780, an estrogen receptor (ER) antagonist, the cell growth was reduced according to its doses. Therefore, the cell proliferation was suggested to generate through ER. Most of these chemicals were also positive using CHOOSER assay, a new method of testing estrogenic activity of xenoestrogen. Each xenoestrogen was also confirmed to bind to ERalpha and ERbeta using a human ER competitive binding assay against 17beta-estradiol. The concentration order of the strength of its inhibitory effect using both ERalpha and ERbeta was similar to that of MCF-7 cell proliferation assay, except for benzyl 4-hydroxybenzoate (B4HB). B4HB showed a stronger activity on CHOOSER assay and the competitive binding assay using both ERalpha and ERbeta, although there was no activity observed on MCF-7 cell proliferation assay. Our findings were to detect the estrogenic activity of etocrylene and octocrylene in vitro, in addition to confirming the activities of some ultraviolet absorbers as previously reported.

  4. Relation Between Myocardial Infarction Deaths and Solar Activity in Mexico

    NASA Astrophysics Data System (ADS)

    Diaz-Sandoval, R.

    2002-05-01

    We study the daily incidence of myocardial infarction deaths in Mexico for 4 years (1996-99) with a total of 129 917 cases in all the country, collected at the General Directorate of Epidemiology (National Ministry of Health). We divided the cases by sex and age and perform two kinds of analysis. First, we did an spectral analysis using the Maximum Entropy Method, considering the complete period, and minimum and maximum epochs of solar activity. The results show that the most persistent periodicity at higher frequencies in the myocardial infarction death occurrence is that of seven days. Considering the solar cycle phases, we found that during solar minimum times some frequencies are not detectable compared with solar maximum epochs, particularly that of seven days. Biological rhythms close to seven days, the circaseptans, are in general thought to be only the result of the social organization of life. However, this cannot be the only explanation, because the 7-days periodicity has been encountered in lower organisms not related with our rhythms of life. Thus, it has been proposed that biological rhythms could be evolutionary adaptations to environmental conditions, particularly, solar activity. In the second analysis we compared two solar activity-related phenomena: the Forbush decreases of cosmic rays and the geomagnetic index Ap for various levels of geomagnetic perturbations. The results show that during decreases of cosmic ray fluxes, for most cases there is a higher average myocardial infarction deaths occurrence, compared with the average incidence in days of no decreases. For geomagnetic activity we find the same situation in most cases. Furthermore, this behavior is more pronounced as the level of the perturbation increases and in times of maximum solar activity.

  5. Neighborhood Crime-Related Safety and Its Relation to Children's Physical Activity.

    PubMed

    Kneeshaw-Price, Stephanie H; Saelens, Brian E; Sallis, James F; Frank, Lawrence D; Grembowski, David E; Hannon, Peggy A; Smith, Nicholas L; Chan, K C Gary

    2015-06-01

    Crime is both a societal safety and public health issue. Examining different measures and aspects of crime-related safety and their correlations may provide insight into the unclear relationship between crime and children's physical activity. We evaluated five neighborhood crime-related safety measures to determine how they were interrelated. We then explored which crime-related safety measures were associated with children's total moderate-to-vigorous physical activity (MVPA) and MVPA in their neighborhoods. Significant positive correlations between observed neighborhood incivilities and parents' perceptions of general crime and disorder were found (r = 0.30, p = 0.0002), as were associations between parents' perceptions of general crime and disorder and perceptions of stranger danger (r = 0.30, p = 0.0002). Parent report of prior crime victimization in their neighborhood was associated with observed neighborhood incivilities (r = 0.22, p = 0.007) and their perceptions of both stranger danger (r = 0.24, p = 0.003) and general crime and disorder (r = 0.37, p < 0.0001). After accounting for covariates, police-reported crime within the census block group in which children lived was associated with less physical activity, both total and in their neighborhood (beta = -0.09, p = 0.005, beta = -0.01, p = 0.02, respectively). Neighborhood-active children living in the lowest crime-quartile neighborhoods based on police reports had 40 min more of total MVPA on average compared to neighborhood-active children living in the highest crime-quartile neighborhoods. Findings suggest that police reports of neighborhood crime may be contributing to lower children's physical activity.

  6. Indications for jaw gape-related control of relative muscle activation in sequent chewing strokes.

    PubMed

    Pröschel, P A; Morneburg, T R

    2010-03-01

    Jaw muscle activity ratios in unilateral isometric biting differ from ratios of unilateral chewing but approach the latter if the jaw gape in biting is made as small as the minimum interocclusal distance (MID) of chewing. Especially, the masseter working/balancing side ratio (W/B-ratio) becomes as asymmetric as in chewing, because of reduction in balancing side (BS) masseter activity. This behaviour of ratios might reflect a 'chewing-specific' motor strategy induced when isometric biting is performed with a 'chewing-like' gape. If this hypothesis applies, activity ratios should be associated with MIDs of sequent chewing strokes in a similar manner as with incremented jaw gapes in isometric biting. To test this prediction, bilateral surface electromyograms of masseter and anterior temporalis muscles and incisor movements were recorded during unilateral chewing in 52 subjects. W/B-ratios of masseter and temporalis activities and temporalis/masseter-ratios on both sides were calculated. The ratios were related to MIDs of consecutive chewing cycles. Three of the four ratios were associated with masticatory MID in the same manner as with jaw gape in isometric biting. In particular with decreasing MID, the masseter W/B-ratio increased from 1.5 to 2.2 (P < 0.01). This increase in asymmetry was attributed to a stronger decrease in masseter activity on the BS than on the working side. We conclude that relative jaw muscle activation is associated with interocclusal distance in a similar way in isometric biting and in chewing. This analogy supports the idea of a common jaw gape-related neuromuscular strategy facilitated by afferent signalling of interocclusal distance.

  7. Reward-related activity in the human motor cortex

    PubMed Central

    Kapogiannis, Dimitrios; Campion, Paul; Grafman, Jordan; Wassermann, Eric M.

    2017-01-01

    The human primary motor cortex (M1) participates in motor learning and response selection, functions that rely on feedback on the success of behavior (i.e. reward). To investigate the possibility that behavioral contingencies alter M1 activity in humans, we tested intracortical inhibition with single and paired (subthreshold/suprathreshold) transcranial magnetic stimulation during a slot machine simulation that delivered variable money rewards for three-way matches and required no movement. A two-way match before the third barrel had stopped (increased reward expectation) was associated with more paired-pulse inhibition than no match. Receiving a large reward on the preceding trial augmented this effect. A control task that manipulated attention to the same stimuli produced no changes in excitability. The origin of this reward-related activity is not clear, although dopaminergic ventral tegmental area neurons project to M1, where they are thought to inhibit output neurons and could be the source of the finding. Transcranial magnetic stimulation of M1 may be useful as a quantitative measure of reward-related activity. PMID:18371077

  8. Physical activity behavior and related characteristics of highly-active 8th grade girls

    PubMed Central

    Taverno Ross, Sharon E.; Dowda, Marsha; Beets, Michael W.; Pate, Russell R.

    2013-01-01

    Purpose While girls are generally less physically active than boys, some girls regularly engage in high levels of physical activity (PA); however, very little is known about these girls and how they differ from those who are less physically active. This study examined the PA behavior and related characteristics of highly-active adolescent girls and compared them with those who are less active. Methods Data from 1,866 8th grade girls from 6 field centers across the U.S. participating in the Trial of Activity for Adolescent Girls (TAAG) were included in the present analysis. Mixed model ANOVAs examined differences in sociodemographic, anthropometric, psychosocial, and physical activity (accelerometry and self-report) variables between high- and low-active girls; effect sizes were calculated for the differences. Results High-active girls were taller, had lower BMIs and body fat, and were less sedentary. High-active girls scored higher on self-efficacy, enjoyment of PA, self-management strategies, outcome-expectancy value, and support from family and friends than low-active girls. Low-active girls participated in more leisure-time and educational sedentary activities than high-active girls. High-active girls participated in more PA classes/lessons outside of school, team sports, and individual sports. They were also more likely to participate in sports in an organized setting in the community or at school than low-active girls. Conclusions Health promotion efforts should focus on decreasing the amount of time girls spend in sedentary activities and replacing that time with organized PA opportunities; such efforts should seek to minimize perceived barriers and increase self-efficacy and support for PA. PMID:23384978

  9. Cerebral Activations Related to Writing and Drawing with Each Hand

    PubMed Central

    Potgieser, Adriaan R. E.; van der Hoorn, Anouk; de Jong, Bauke M.

    2015-01-01

    Background Writing is a sequential motor action based on sensorimotor integration in visuospatial and linguistic functional domains. To test the hypothesis of lateralized circuitry concerning spatial and language components involved in such action, we employed an fMRI paradigm including writing and drawing with each hand. In this way, writing-related contributions of dorsal and ventral premotor regions in each hemisphere were assessed, together with effects in wider distributed circuitry. Given a right-hemisphere dominance for spatial action, right dorsal premotor cortex dominance was expected in left-hand writing while dominance of the left ventral premotor cortex was expected during right-hand writing. Methods Sixteen healthy right-handed subjects were scanned during audition-guided writing of short sentences and simple figure drawing without visual feedback. Tapping with a pencil served as a basic control task for the two higher-order motor conditions. Activation differences were assessed with Statistical Parametric Mapping (SPM). Results Writing and drawing showed parietal-premotor and posterior inferior temporal activations in both hemispheres when compared to tapping. Drawing activations were rather symmetrical for each hand. Activations in left- and right-hand writing were left-hemisphere dominant, while right dorsal premotor activation only occurred in left-hand writing, supporting a spatial motor contribution of particularly the right hemisphere. Writing contrasted to drawing revealed left-sided activations in the dorsal and ventral premotor cortex, Broca’s area, pre-Supplementary Motor Area and posterior middle and inferior temporal gyri, without parietal activation. Discussion The audition-driven postero-inferior temporal activations indicated retrieval of virtual visual form characteristics in writing and drawing, with additional activation concerning word form in the left hemisphere. Similar parietal processing in writing and drawing pointed at a

  10. Convulsion-related activities of Scutellaria flavones are related to the 5,7-dihydroxyl structures.

    PubMed

    Yoon, Seo Young; dela Peña, Ike Campomayor; Shin, Chan Young; Son, Kun Ho; Lee, Yong Soo; Ryu, Jong Hoon; Cheong, Jae Hoon; Ko, Kwang Ho

    2011-06-01

    We screened the major bioactive flavones isolated from Scutellaria baicalensis (baicalin, baicalein and oroxylin A) for their convulsion related activities. In electrogenic response score system and the pentylenetetrazole seizure model, baicalein but not oroxylin A and baicalin exhibited anticonvulsant effects. In vitro studies also revealed that baicalein induced intracellular Cl(-) influx, whereas oroxylin A blocked muscimol- and baicalein-induced intracellular Cl(-) influx. The anticonvulsant effect of baicalein was inhibited by flumazenil, a benzodiazepine(BZD) receptor antagonist. Therefore, anticonvulsive effect of baicalein was mediated by the BZD binding site of GABA(A) receptor. The 5, 7-dihydroxyl group is present in the structure of the three flavones. It is postulated that this group played a key role in inducing convulsion-related activities.

  11. Simulating Activities: Relating Motives, Deliberation and Attentive Coordination

    NASA Technical Reports Server (NTRS)

    Clancey, William J.; Clancy, Daniel (Technical Monitor)

    2002-01-01

    Activities are located behaviors, taking time, conceived as socially meaningful, and usually involving interaction with tools and the environment. In modeling human cognition as a form of problem solving (goal-directed search and operator sequencing), cognitive science researchers have not adequately studied "off-task" activities (e.g., waiting), non-intellectual motives (e.g., hunger), sustaining a goal state (e.g., playful interaction), and coupled perceptual-motor dynamics (e.g., following someone). These aspects of human behavior have been considered in bits and pieces in past research, identified as scripts, human factors, behavior settings, ensemble, flow experience, and situated action. More broadly, activity theory provides a comprehensive framework relating motives, goals, and operations. This paper ties these ideas together, using examples from work life in a Canadian High Arctic research station. The emphasis is on simulating human behavior as it naturally occurs, such that "working" is understood as an aspect of living. The result is a synthesis of previously unrelated analytic perspectives and a broader appreciation of the nature of human cognition. Simulating activities in this comprehensive way is useful for understanding work practice, promoting learning, and designing better tools, including human-robot systems.

  12. Activity loss and depression in age-related macular degeneration.

    PubMed

    Rovner, Barry W; Casten, Robin J

    2002-01-01

    Age-related macular degeneration (AMD) is the most frequent cause of severe vision loss in older persons and is associated with high rates of disability and depression. The authors evaluated 51 patients with bilateral AMD to investigate the interrelationships of disease severity, disability, and depression and focused on loss of valued activities as an emblematic disabling consequence of AMD. They characterized depression by the Center for Epidemiologic Studies-Depression (CES-D) score, a syndromal state based on the CES-D, and as a level of distress (Index of Affective Suffering; IAS). Thirty subjects (58.8%) had loss of a valued, discretionary activity. They had worse visual acuity and more depressive symptoms and were represented in higher IAS levels than other subjects. Visual acuity was significantly correlated with IAS levels, but not with CES-D scores or syndromal depression. A regression model demonstrated that activity loss mediated the relationship between visual acuity and IAS level. Affective distress occurs in AMD, largely to the extent that valued activities are relinquished because of vision loss. IAS levels best illuminated this relationship, suggesting the value of this dimension of affective functioning in studies of the consequences of chronic disease.

  13. UTSI/CFFF MHD PROGRAM COMPLETION AND RELATED ACTIVITY

    SciTech Connect

    Unknown

    2002-12-31

    Maintenance work on the DOE CFFF facility and other related government property is no longer authorized under this contract in accordance with the DOE-UT Settlement Agreement. Environmental remediation preservation of the facility continued. Government property has been transferred to UTSI as owner which frees up many items for proper disposal. Actions are underway to dispose of other wastes, and control pests and water at the DOE CFFF. Groundwater remediation activities as mandated by the Tennessee Department of Environment and Conservation (TDEC) continued throughout the quarter. A contract was awarded to an environmental consulting company to drill and sample three additional groundwater wells adjacent to the CFFF property. A report on this activity, with results of the sample analysis, has been sent to the TDEC.

  14. Rocket effluent: Its ice nucleation activity and related properties

    NASA Technical Reports Server (NTRS)

    Parungo, F. P.; Allee, P. A.

    1978-01-01

    To investigate the possibility of inadvertent weather modification from rocket effluent, aerosol samples were collected from an instrumented aircraft subsequent to the Voyager 1 and 2 launches. The aerosol's morphology, concentration, and size distribution were examined with an electron microscope. The elemental compositions of individual particles were analyzed with an X-ray energy spectrometer. Ice nucleus concentration was measured with a thermal diffusion chamber. The particles' physical and chemical properties were related to their ice nucleation activity. A laboratory experiment on rocket propellant exhaust was conducted under controlled conditions. Both laboratory and field experimental results indicated that rocket propellant exhaust can produce active ice nuclei and modify local weather in suitable meteorological conditions.

  15. Towards age/rotation/magnetic activity relation with seismology

    NASA Astrophysics Data System (ADS)

    Mathur, Savita

    2015-09-01

    The knowledge of stellar ages directly impacts the characterization of a planetary system as it puts strong constraints on the moment when the system was born. Unfortunately, the determination of precise stellar ages is a very difficult task. Different methods can be used to do so (based on isochrones or chemical element abundances) but they usually provide large uncertainties. During its evolution a star goes through processes leading to loss of angular momentum but also changes in its magnetic activity. Building rotation, magnetic, age relations would be an asset to infer stellar ages model independently. Several attempts to build empirical relations between rotation and age (namely gyrochronology) were made with a focus on cluster stars where the age determination is easier and for young stars on the main sequence. For field stars, we can now take advantage of high-precision photometric observations where we can perform asteroseismic analyses to improve the accuracy of stellar ages. Furthermore, the variability in the light curves allow us to put strong constraints on the stellar rotation and magnetic activity. By combining these precise measurements, we are on the way of understanding and improving relations between magnetic activity, rotation, and age, in particular at different stages of stellar evolution. I will review the status on gyrochronology relationships based on observations of young cluster stars. Then I will focus on solar-like stars and describe the inferences on stellar ages, rotation, and magnetism that can be provided by high-quality photometric observations such as the ones of the Kepler mission, in particular through asteroseismic analyses.

  16. PHYSICAL FIDELITY CONSIDERATIONS FOR NRC ADVANCED REACTOR CONTROL ROOM TRAINING SIMULATORS USED FOR INSPECTOR/EXAMINER TRAINING

    SciTech Connect

    Branch, Kristi M.; Mitchell, Mark R.; Miller, Mark; Cochrum, Steven

    2010-11-07

    This paper describes research into the physical fidelity requirements of control room simulators to train U.S. Nuclear Regulatory Commission (NRC) staff for their duties as inspectors and license examiners for next-generation nuclear power plants. The control rooms of these power plants are expected to utilize digital instrumentation and controls to a much greater extent than do current plants. The NRC is assessing training facility needs, particularly for control room simulators, which play a central role in NRC training. Simulator fidelity affects both training effectiveness and cost. Research has shown high simulation fidelity sometimes positively affects transfer to the operational environment but sometimes makes no significant difference or actually impedes learning. The conditions in which these different effects occur are often unclear, especially for regulators (as opposed to operators) about whom research is particularly sparse. This project developed an inventory of the tasks and knowledges, skills, and abilities that NRC regulators need to fulfill job duties and used expert panels to characterize the inventory items by type and level of cognitive/behavioral capability needed, difficulty to perform, importance to safety, frequency of performance, and the importance of simulator training for learning these capabilities. A survey of current NRC staff provides information about the physical fidelity of the simulator on which the student trained to the control room to which the student was assigned and the effect lack of fidelity had on learning and job performance. The study concludes that a high level of physical fidelity is not required for effective training of NRC staff.

  17. Thyroid cancer incidence in relation to volcanic activity

    SciTech Connect

    Arnbjoernsson, E.A.; Arnbjoernsson, A.O.; Olafsson, A.

    1986-01-01

    Environmental or genetic factors are sought to explain the high incidence of thyroid cancer in Iceland. At present, it is impossible to cite any environmental factor, particularly one related to the volcanic activity in the country, which could explain the high incidence of thyroid cancer in Iceland. However, the thyroid gland in Icelanders is very small due to the high intake of iodine from seafood. It is, therefore, easier for physicians to find thyroid tumors. Furthermore, genetic factors are very likely to be of great importance in the small, isolated island of Iceland.

  18. Gaming is related to enhanced working memory performance and task-related cortical activity.

    PubMed

    Moisala, M; Salmela, V; Hietajärvi, L; Carlson, S; Vuontela, V; Lonka, K; Hakkarainen, K; Salmela-Aro, K; Alho, K

    2017-01-15

    Gaming experience has been suggested to lead to performance enhancements in a wide variety of working memory tasks. Previous studies have, however, mostly focused on adult expert gamers and have not included measurements of both behavioral performance and brain activity. In the current study, 167 adolescents and young adults (aged 13-24 years) with different amounts of gaming experience performed an n-back working memory task with vowels, with the sensory modality of the vowel stream switching between audition and vision at random intervals. We studied the relationship between self-reported daily gaming activity, working memory (n-back) task performance and related brain activity measured using functional magnetic resonance imaging (fMRI). The results revealed that the extent of daily gaming activity was related to enhancements in both performance accuracy and speed during the most demanding (2-back) level of the working memory task. This improved working memory performance was accompanied by enhanced recruitment of a fronto-parietal cortical network, especially the dorsolateral prefrontal cortex. In contrast, during the less demanding (1-back) level of the task, gaming was associated with decreased activity in the same cortical regions. Our results suggest that a greater degree of daily gaming experience is associated with better working memory functioning and task difficulty-dependent modulation in fronto-parietal brain activity already in adolescence and even when non-expert gamers are studied. The direction of causality within this association cannot be inferred with certainty due to the correlational nature of the current study.

  19. EPA's Science Plan for Activities Related to Dioxins in the ...

    EPA Pesticide Factsheets

    The U.S. Environmental Protection Agency is currently addressing several issues related to dioxins and dioxin-like chemicals in the environment. These include the comprehensive human health and exposure assessment for dioxin, commonly called the dioxin reassessment and a review of dioxin soil clean-up levels currently in use across the United States. To move forward with both of these efforts, as well as other dioxin related activities, a plan with interim milestones has been developed and it is outlined below. EPA’sExposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD) and Related Compounds; Response to NAS and Completion of Dioxin Reassessment 1. EPA will release a draft report that responds to the recommendations and comments included in the National Academy of Sciences’ (NAS) 2006 review of EPA’s 2003 draft dioxin reassessment. UPDATED May 21, 2010: The draft response to comments report titled EPA’s Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (External Review Draft) (“Draft Dioxin Reanalysis”) was completed and released for public review and comment on May 21, 2010. EPA’s National Center for Environment Assessment (NCEA) in the Office of Research and Development, will prepare a limited response to key comments and recommendations in the NAS report (draft response to comments report). The draft response will focus on dose-response

  20. Proteomic analysis of acidic chaperones, and stress proteins in extreme halophile Halobacterium NRC-1: a comparative proteomic approach to study heat shock response

    PubMed Central

    Shukla, Hem D

    2006-01-01

    Background Halobacterium sp. NRC-1 is an extremely halophilic archaeon and has adapted to optimal growth under conditions of extremely high salinity. Its proteome is highly acidic with a median pI of 4.9, a unique characteristic which helps the organism to adapt high saline environment. In the natural growth environment, Halobacterium NRC-1 encounters a number of stressful conditions including high temperature and intense solar radiation, oxidative and cold stress. Heat shock proteins and chaperones play indispensable roles in an organism's survival under many stress conditions. The aim of this study was to develop an improved method of 2-D gel electrophoresis with enhanced resolution of the acidic proteome, and to identify proteins with diverse cellular functions using in-gel digestion and LC-MS/MS and MALDI-TOF approach. Results A modified 2-D gel electrophoretic procedure, employing IPG strips in the range of pH 3–6, enabled improved separation of acidic proteins relative to previous techniques. Combining experimental data from 2-D gel electrophoresis with available genomic information, allowed the identification of at least 30 cellular proteins involved in many cellular functions: stress response and protein folding (CctB, PpiA, DpsA, and MsrA), DNA replication and repair (DNA polymerase A α subunit, Orc4/CDC6, and UvrC), transcriptional regulation (Trh5 and ElfA), translation (ribosomal proteins Rps27ae and Rphs6 of the 30 S ribosomal subunit; Rpl31eand Rpl18e of the 50 S ribosomal subunit), transport (YufN), chemotaxis (CheC2), and housekeeping (ThiC, ThiD, FumC, ImD2, GapB, TpiA, and PurE). In addition, four gene products with undetermined function were also identified: Vng1807H, Vng0683C, Vng1300H, and Vng6254. To study the heat shock response of Halobacterium NRC-1, growth conditions for heat shock were determined and the proteomic profiles under normal (42°C), and heat shock (49°C) conditions, were compared. Using a differential proteomic approach in