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Sample records for nsoi enhancing international

  1. The National Coalition for Sustained Optimal Iodine intake (NSOI): a case study of a successful experience from India.

    PubMed

    Yadav, Kapil; Chakrabarty, Arijit; Rah, Jee Hyun; Kumar, Rakesh; Aguayo, Victor; Ansari, Mohammad Anas; Sankar, Rajan; Karmarkar, Madhu Ganesh; Pandav, Chandrakant S

    2014-01-01

    Iodine deficiency disorders (IDD) constitute the single most important preventable cause of mental handicap at global level. Recognizing the importance of coordination and synergy of the activities of wide range of universal salt iodisation (USI) stakeholders, WHO/ Unicef/ ICCIDD has prescribed a national multi-sectoral coalition as one of the ten indicators essential for attaining sustainable elimination of IDD at national level. Challenge for coordination among different stakeholders of IDD/USI is even greater in democratic and diverse country like India. In the present article we present successful experience from India regarding formation of a national coalition and contributions made by the coalition towards promoting USI in India. The activities of the national coalition in India are classified into three phases; 1) Phase 1- year 2006 to 2009- the inception; 2) Phase 2- year 2009 to 2012- consolidation; 3) Phase 3- year 2013 and ongoing- expansion. The National coalition for Sustained Optimal Iodine Intake (NSOI) has been instrumental in ensuring greater coordination and synergy amongst IDD and USI stakeholders in India and partially responsible for the current 71 percentage household level coverage of adequately iodised salt. The most significant contribution of the national coalition has been to act as a high level advocacy channel and provide a platform for regular dialogue for all partners of the coalition. With "mission" approach and allocation of optimal resource, India can achieve and should achieve USI by 2015, an apt culmination of a decade of existence of the national coalition. PMID:25384725

  2. Enhancing the International X-ray Observatory

    NASA Astrophysics Data System (ADS)

    Danner, Rolf; Dailey, D.; Lillie, C.

    2010-03-01

    We present results of systems studies expected to significantly enhance the science utility and reduce technical as well as cost risks for the International X-ray Observatory (IXO). Our Northrop Grumman team draws on the experience of building and operating Chandra and others of NASA's premier astrophysical observatories (Compton Gamma Ray Observatory, James Webb Space Telescope) as well as our experience as a leading developer of deployable space structures. For IXO, we have developed (a) an optical bench concept that has the potential to increase the focal length from 20 to 25 m within the current mass and stability requirements; (b) an instrument and system layout that increases the accessible field of regard; and (c) a number of design choices based on flight proven concepts that reduce cost risk. Our concept for the IXO deployable bench is a Tensegrity structure formed by two telescoping booms (compression) and a hexapod cable (tension) truss. This arrangement achieves the required stiffness for the optical bench at minimal mass while employing only high TRL components and flight proven elements. While the overall concept is innovative and will require further evaluation, it is based on existing elements, can be fully tested on the ground and does not require any new technology. We have also explored the options opened by using hinged, articulating solar panels, and found that when used along with a fully enclosed MLI tent surrounding the optical bench, and an instrument module utilizing radially facing radiator panels, the enhanced configuration will enable us to greatly increase IXO's field of regard without distorting the optical bench beyond acceptable tolerances, making more of the sky accessible for observation at any given time.

  3. Enhancing the International X-Ray Observatory

    NASA Astrophysics Data System (ADS)

    Dailey, Dean; Danner, Rolf; Lillie, Chuck

    2009-09-01

    We present preliminary results of systems studies expected to significantly enhance the science utility and reduce technical as well as cost risks for the International X-ray Observatory (IXO). Our Northrop Grumman team draws on the experience of building and operating Chandra and others of NASA's premier astrophysical observatories (Compton Gamma Ray Observatory, James Webb Space Telescope) as well as our experience as a leading developer of deployable space structures. For IXO, we have developed (a) an optical bench concept that increases the focal length from 20 to 25 m within the current mass and stability requirements; (b) an instrument and system layout that increases the accessible field of regard; and (c) a number of design choices based on flight proven concepts that reduce cost risk. Our concept for the IXO deployable bench is a tensegrity structure formed by two telescoping booms (compression) and a hexapod cable (tension) truss. This arrangement achieves the required stiffness for the optical bench at minimal mass while employing only high TRL components and flight proven elements. While the overall concept is innovative and will require further evaluation, it is based on existing elements, can be fully tested on the ground and does not require any new technology. We have also explored the options opened by using hinged, articulating solar panels, and found that when used along with a fully enclosed MLI tent surrounding the optical bench, and an instrument module utilizing radially facing radiator panels, the enhanced configuration will enable us to greatly increase IXO's field of regard without distorting the optical bench beyond acceptable tolerances, making more of the sky accessible for observation at any given time.

  4. Enhancing the International X-ray Observatory

    NASA Astrophysics Data System (ADS)

    Danner, Rolf; Dailey, D.; Lillie, C.

    2010-01-01

    We present preliminary results of systems studies expected to significantly enhance the science utility and reduce technical as well as cost risks for the International X-ray Observatory (IXO). Our Northrop Grumman team draws on the experience of building and operating Chandra and others of NASA's premier astrophysical observatories (Compton Gamma Ray Observatory, James Webb Space Telescope) as well as our experience as a leading developer of deployable space structures. For IXO, we have developed (a) an optical bench concept that increases the focal length from 20 to 25 m within the current mass and stability requirements; (b) an instrument and system layout that increases the accessible field of regard; and (c) a number of design choices based on flight proven concepts that reduce cost risk. Our concept for the IXO deployable bench is a Tensegrity structure formed by two telescoping booms (compression) and a hexapod cable (tension) truss. This arrangement achieves the required stiffness for the optical bench at minimal mass while employing only high TRL components and flight proven elements. While the overall concept is innovative and will require further evaluation, it is based on existing elements, can be fully tested on the ground and does not require any new technology. We have also explored the options opened by using hinged, articulating solar panels, and found that when used along with a fully enclosed MLI tent surrounding the optical bench, and an instrument module utilizing radially facing radiator panels, the enhanced configuration will enable us to greatly increase IXO's field of regard without distorting the optical bench beyond acceptable tolerances, making more of the sky accessible for observation at any given time.

  5. Enhancing nuclear emergency response through international cooperation.

    PubMed

    Ugletveit, Finn; Aaltonen, Hannele

    2004-01-01

    Nuclear and radiological emergencies may easily become severe international emergencies requiring substantial resources in several or many states for an adequate response, which in some cases may require resources exceeding national capabilities. Through the development of a consistent, coherent and sustainable joint programme for improved and more efficient international responses to nuclear and radiological emergencies, it is believed that we could achieve a better and more cost-effective response capability for nuclear and radiological emergencies. This requires, however, that we be willing and able to establish mechanisms of assistance where information and resources are globally shared and that standardised/harmonised procedures be developed and implemented. If we are willing to make this investment, we believe that, in the long term, there will be a significant benefit for all of us. PMID:15238674

  6. Enhancing the International X-ray Observatory

    NASA Astrophysics Data System (ADS)

    Danner, Rolf; Dailey, Dean; Lillie, Charles; Spittler, Connie

    2010-07-01

    Over the last two years, we have studied system concepts for the International X-ray Observatory (IXO) with the goal of increasing the science return of the mission and to reduce technical and cost risk. We have developed an optical bench concept that has the potential to increase the focal length from 20 to 25 m within the current mass and stability requirements. Our deployable bench is a tensegrity structure formed by two telescoping booms (compression) and a hexapod cable (tension) truss. This arrangement achieves the required stiffness for the optical bench at minimal mass while employing only high TRL components and flight proven elements. The concept is based on existing elements, can be fully tested on the ground and does not require new technology. Our design further features hinged, articulating solar panels, an optical bench fully enclosed in MLI and an instrument module with radially facing radiator panels. We find that our design can be used over a wide range of sun angles, thereby greatly increasing IXO's field of regard, without distorting the optical bench. This makes a much larger fraction of the sky instantaneously accessible to IXO.

  7. Enhanced efficiency of internal combustion engines by employing spinning gas

    NASA Astrophysics Data System (ADS)

    Geyko, V. I.; Fisch, N. J.

    2014-08-01

    The efficiency of the internal combustion engine might be enhanced by employing spinning gas. A gas spinning at near sonic velocities has an effectively higher heat capacity, which allows practical fuel cycles, which are far from the Carnot efficiency, to approach more closely the Carnot efficiency. A remarkable gain in fuel efficiency is shown to be theoretically possible for the Otto and Diesel cycles. The use of a flywheel, in principle, could produce even greater increases in efficiency.

  8. Enhanced efficiency of internal combustion engines by employing spinning gas.

    PubMed

    Geyko, V I; Fisch, N J

    2014-08-01

    The efficiency of the internal combustion engine might be enhanced by employing spinning gas. A gas spinning at near sonic velocities has an effectively higher heat capacity, which allows practical fuel cycles, which are far from the Carnot efficiency, to approach more closely the Carnot efficiency. A remarkable gain in fuel efficiency is shown to be theoretically possible for the Otto and Diesel cycles. The use of a flywheel, in principle, could produce even greater increases in efficiency. PMID:25215720

  9. Enhanced efficiency of internal combustion engines by employing spinning gas.

    PubMed

    Geyko, V I; Fisch, N J

    2014-08-01

    The efficiency of the internal combustion engine might be enhanced by employing spinning gas. A gas spinning at near sonic velocities has an effectively higher heat capacity, which allows practical fuel cycles, which are far from the Carnot efficiency, to approach more closely the Carnot efficiency. A remarkable gain in fuel efficiency is shown to be theoretically possible for the Otto and Diesel cycles. The use of a flywheel, in principle, could produce even greater increases in efficiency.

  10. Enhanced Efficiency of Internal Combustion Engines By Employing Spinning Gas

    SciTech Connect

    Geyko, Vasily; Fisch, Nathaniel

    2014-02-27

    The efficiency of the internal combustion engine might be enhanced by employing spinning gas. A gas spinning at near sonic velocities has an effectively higher heat capacity, which allows practical fuel cycles, which are far from the Carnot efficiency, to approach more closely the Carnot efficiency. A gain in fuel efficiency of several percent is shown to be theoretically possible for the Otto and Diesel cycles. The use of a flywheel, in principle, could produce even greater increases in the efficiency.

  11. Enhanced radiation therapy with internalized polyelectrolyte modified nanoparticles

    NASA Astrophysics Data System (ADS)

    Zhang, Peipei; Qiao, Yong; Wang, Chaoming; Ma, Liyuan; Su, Ming

    2014-08-01

    A challenge of X-ray radiation therapy is that high dose X-ray under therapeutic conditions damages normal cells. This paper describes a nanoparticle-based method to enhance X-ray radiation therapy by delivering radio-sensitizing gold nanoparticles into cancer cells. The nanoparticles have been modified with cationic polyelectrolytes to allow internalization. Upon X-ray irradiation of nanoparticles, more photoelectrons and Auger electrons are generated to cause water ionization, leading to formation of free radicals that damage DNA of cancer cells. The X-ray dose required for DNA damage and cell killing is reduced by delivering gold nanoparticles inside cancer cells.

  12. Strategies of polymeric nanoparticles for enhanced internalization in cancer therapy.

    PubMed

    Sun, Lu; Wu, Qinjie; Peng, Feng; Liu, Lei; Gong, Changyang

    2015-11-01

    In order to achieve long circulation time and high drug accumulation in the tumor sites via the EPR effects, anticancer drugs have to be protected by non-fouling polymers such as poly(ethylene glycol) (PEG), poly(ethylene oxide) (PEO), dextran, and poly(acrylic acid) (PAA). However, the dense layer of stealth polymer also prohibits efficient uptake of anticancer drugs by target cancer cells. For cancer therapy, it is often more desirable to accomplish rapid cellular uptake after anticancer drugs arriving at the pathological site, which could on one hand maximize the therapeutic efficacy and on the other hand reduce probability of drug resistance in cells. In this review, special attention will be focused on the recent potential strategies that can enable drug-loaded polymeric nanoparticles to rapidly recognize cancer cells, leading to enhanced internalization. PMID:26241917

  13. Strategies of polymeric nanoparticles for enhanced internalization in cancer therapy.

    PubMed

    Sun, Lu; Wu, Qinjie; Peng, Feng; Liu, Lei; Gong, Changyang

    2015-11-01

    In order to achieve long circulation time and high drug accumulation in the tumor sites via the EPR effects, anticancer drugs have to be protected by non-fouling polymers such as poly(ethylene glycol) (PEG), poly(ethylene oxide) (PEO), dextran, and poly(acrylic acid) (PAA). However, the dense layer of stealth polymer also prohibits efficient uptake of anticancer drugs by target cancer cells. For cancer therapy, it is often more desirable to accomplish rapid cellular uptake after anticancer drugs arriving at the pathological site, which could on one hand maximize the therapeutic efficacy and on the other hand reduce probability of drug resistance in cells. In this review, special attention will be focused on the recent potential strategies that can enable drug-loaded polymeric nanoparticles to rapidly recognize cancer cells, leading to enhanced internalization.

  14. Enhanced bioactivity of internally functionalized cationic dendrimers with PEG cores

    PubMed Central

    Albertazzi, Lorenzo; Mickler, Frauke M.; Pavan, Giovanni M.; Salomone, Fabrizio; Bardi, Giuseppe; Panniello, Mariangela; Amir, Elizabeth; Kang, Taegon; Killops, Kato L.; Bräuchle, Christoph; Amir, Roey J.; Hawker, Craig J.

    2012-01-01

    Hybrid dendritic-linear block copolymers based on a 4-arm polyethylene glycol (PEG) core were synthesized using an accelerated AB2/CD2 dendritic growth approach through orthogonal amine/epoxy and thiol-yne chemistries. The biological activity of these 4-arm and the corresponding 2-arm hybrid dendrimers revealed an enhanced, dendritic effect with an exponential increase in cell internalization concomitant with increasing amine end-groups and low cytotoxicity. Furthermore, the ability of these hybrid dendrimers to induce endosomal escape combined with their facile and efficient synthesis makes them attractive platforms for gene transfection. The 4-arm-based dendrimer showed significantly improved DNA binding and gene transfection capabilities in comparison with the 2-arm derivative. These results combined with the MD simulation indicate a significant effect of both the topology of the PEG core and the multivalency of these hybrid macromolecules, on their DNA binding and delivery capablities. PMID:23140570

  15. Determining information management needs for enhanced international safeguards

    SciTech Connect

    Badalamente, R.V.; DeLand, S.M.; Whiteson, R.; Anzelon, G.

    1994-08-01

    The Safeguards Information Management System initiative is a program of the Department of Energy`s (DOE) Office of Arms Control and Nonproliferation aimed at supporting the International Atomic Energy Agency`s (IAEA) efforts to strengthen safeguards through the enhancement of information management capabilities. The DOE hopes to provide the IAEA with the ability to correlate and analyze data from existing and new sources of information, including publicly available information, information on imports and exports, design information, environmental monitoring data, and non-safeguards information. The first step in this effort is to identify and define IAEA requirements. In support of this, we have created a users` requirements document based on interviews with IAEA staff that describes the information management needs of the end user projected by the IAEA, including needs for storage, retrieval, analysis, communication, and visualization of data. Also included are characteristics of the end user and attributes of the current environment. This paper describes our efforts to obtain the required information. We discuss how to accurately represent user needs and involve users for an international organization with a multi-cultural user population. We describe our approach, our experience in setting up and conducting the interviews and brainstorming sessions, and a brief discussion of what we learned.

  16. Enhanced science capability on the International Space Station

    NASA Astrophysics Data System (ADS)

    Felice, Ronald R.; Kienlen, Mike

    2002-12-01

    It is inevitable that the International Space Station (ISS) will play a significant role in the conduct of science in space. However, in order to provide this service to a wide and broad community and to perform it cost effectively, alternative concepts must be considered to complement NASA"s Institutional capability. Currently science payload forward and return data services must compete for higher priority ISS infrastructure support requirements. Furthermore, initial astronaut crews will be limited to a single shift. Much of their time and activities will be required to meet their physical needs (exercise, recreation, etc.), station maintenance, and station operations, leaving precious little time to actively conduct science payload operations. ISS construction plans include the provisioning of several truss mounted, space-hardened pallets, both zenith and nadir facing. The ISS pallets will provide a platform to conduct both earth and space sciences. Additionally, the same pallets can be used for life and material sciences, as astronauts could place and retrieve sealed canisters for long-term micro-gravity exposure. Thus the pallets provide great potential for enhancing ISS science return. This significant addition to ISS payload capacity has the potential to exacerbate priorities and service contention factors within the exiting institution. In order to have it all, i.e., more science and less contention, the pallets must be data smart and operate autonomously so that NASA institutional services are not additionally taxed. Specifically, the "Enhanced Science Capability on the International Space Station" concept involves placing data handling and spread spectrum X-band communications capabilities directly on ISS pallets. Spread spectrum techniques are considered as a means of discriminating between different pallets as well as to eliminate RFI. The data and RF systems, similar to that of "free flyers", include a fully functional command and data handling system

  17. International Students' Enhanced Academic Performance: Effects of Campus Resources

    ERIC Educational Resources Information Center

    Banjong, Delphine N.

    2015-01-01

    This article investigates international students' challenges, such as financial, English proficiency, loneliness/homesickness in the United States. In addition, it assesses how these students coped with such difficulties by making use of resources on campus, such as an international center, writing center, counseling center, and the student…

  18. Enhancing International Students' Experiences: An Imperative Agenda for Universities in the UK

    ERIC Educational Resources Information Center

    Ramachandran, Narayanan T.

    2011-01-01

    The role of international students as catalysts for internationalization and related reforms in the UK higher education sector is increasing. With the growing number of international students, administrators and academics are identifying ways to enable international students to adapt to the UK environment and enhance their experiences as students.…

  19. The Role of International Research Collaboration in Enhancing Global Presence of an Institution

    ERIC Educational Resources Information Center

    Ao, Fiona Ka Wa

    2012-01-01

    In recent decades, higher education institutions have steadily increased their international involvement in response to globalization. High-level research is generally a key component in efforts to increase international visibility (Armstrong, 2007). International research collaborations are perceived to be an important way to enhance global…

  20. Ocean science. Enhanced: internal tides and ocean mixing.

    PubMed

    Garrett, Chris

    2003-09-26

    Recent satellite and in situ observations have shown that at ocean ridges and other seafloor topographic features, a substantial amount of energy is transferred from the main ocean tides into "internal tides." In his Perspective, Garrett explains how these internal waves with tidal periods propagate through the density-stratified deep ocean and eventually break down into turbulence. The resulting mixing affects ocean stratification and ocean circulation. It thus influences climate as well as biological production. The energy for the internal tides is derived from the rotational energy of the Earth-Moon system changes of the length of the day and the distance to the Moon. PMID:14512611

  1. The International Children's Digital Library Enhances the Multicultural Collection

    ERIC Educational Resources Information Center

    Lemmons, Karen

    2009-01-01

    In this article, the author talks about the International Children's Digital Library (ICDL), an online digital library which gives students an opportunity to read and learn about other cultures and countries in a different way. The library's web site (http://www.icdlbooks.org) was designed by children, with the guidance and expertise of adults.…

  2. Enhanced transfection of brain tumor suppressor genes by photochemical internalization

    NASA Astrophysics Data System (ADS)

    Chou, Chih H.; Sun, Chung-Ho; Zhou, Yi-Hong; Madsen, Steen J.; Hirschberg, Henry

    2011-03-01

    One of many limitations for cancer gene therapy is the inability of the therapeutic gene to transfect a sufficient number of tumor cells. Photochemical internalization (PCI) is a photodynamic therapy-based approach for improving the delivery of macromolecules and genes into the cell cytosol. The utility of PCI for the delivery of a tumor suppressor gene (PAX-6) was investigated in monolayers and spheroids consisting of F98 rat glioma cells.

  3. Enhancing international radiation/nuclear detection training opportunities

    SciTech Connect

    Williams, Thomas L.; Bersell, Bridget M.; Booker, Paul M.; Anderson, Gerald E.; Leitch, Rosalyn M.; Meagher, John B.; Siefken, Rob R.; Spracklen, James L.

    2015-09-23

    The United States has worked domestically to develop and provide radiological and nuclear detection training and education initiatives aimed at interior law enforcement, but the international community has predominantly focused efforts at border and customs officials. The interior law enforcement officials of a State play a critical role in maintaining an effective national-level nuclear detection architecture. To meet this vital need, DNDO was funded by the U.S. Department of State (DOS) to create and deliver a 1-week course at the International Law Enforcement Academy (ILEA) in Budapest, Hungary to inform interior law enforcement personnel of the overall mission, and to provide an understanding of how the participants can combat the threats of radiological and nuclear terrorism through detection efforts. Two courses, with approximately 20 students in each course, were delivered in fiscal year (FY) 2013, two were delivered in FY 2014 and FY 2015, and as of this report’s writing more are planned in FY 2016. However, while the ILEA courses produced measurable success, DNDO requested Pacific Northwest National Laboratory (PNNL) research potential avenues to further increase the course impact.In a multi-phased approach, PNNL researched and analyzed several possible global training locations and venues, and other possible ways to increase the impact of the course using an agreed-to data-gathering format.

  4. Enhanced internal reflection microscopy for subsurface damage inspection

    NASA Astrophysics Data System (ADS)

    Xu, Longbo; Ni, Kaizao; Zhu, Rihong; Liu, Xiaofeng; Liu, Shijie; Zhang, Bo; Shao, Jianda

    2016-07-01

    A new method is proposed to inspect the subsurface damage (SSD) that plays a key role on improving the laser induced damage threshold (LIDT) of optics applied in high power laser system. This method is based on total internal reflection microscopy (TIRM) and digital image processing technique. Because of relatively small depth of focus of a microscope at large magnification, a series of TIRM images can be obtained while the microscope focuses into different depths of sample by micro-focusing control. Definition of each image is calculated through wavelet transform. The relation between definition of TIRM images and the depth of SSD is established. According to the definition curve, the position and size along the depth direction can be acquired simultaneously. The measurement accuracy is dependent on the depth of field of microscope. This proposed method has been applied to measure the SSD information of finished K9 glass, fused silica glass and Nd-doped glass.

  5. Enhanced International Space Station Ku-Band Telemetry Service

    NASA Technical Reports Server (NTRS)

    Cecil, Andrew J.; Pitts, R. Lee; Welch, Steven J.; Bryan, Jason D.

    2014-01-01

    The International Space Station (ISS) is in an operational configuration. To fully utilize the ISS and take advantage of the modern protocols and updated Ku-band access, the Huntsville Operations Support Center (HOSC) has designed an approach to extend the Kuband forward link access for payload investigators to their on-orbit payloads. This dramatically increases the ground to ISS communications for those users. This access also enables the ISS flight controllers operating in the Payload Operations and Integration Center to have more direct control over the systems they are responsible for managing and operating. To extend the Ku-band forward link to the payload user community the development of a new command server is necessary. The HOSC subsystems were updated to process the Internet Protocol Encapsulated packets, enable users to use the service based on their approved services, and perform network address translation to insure that the packets are forwarded from the user to the correct payload repeating that process in reverse from ISS to the payload user. This paper presents the architecture, implementation, and lessons learned. This will include the integration of COTS hardware and software as well as how the device is incorporated into the operational mission of the ISS. Thus, this paper also discusses how this technology can be applicable to payload users of the ISS.

  6. Research Experience for Undergraduates: an International Program Enhancing Interdisciplinary Learning

    NASA Astrophysics Data System (ADS)

    Pfiffner, S. M.; Davis, K. L.; Phelps, T. J.; Kieft, T. L.; Gihring, T. M.; Onstott, T. C.; Nthangeni, B.; Piater, L.; van Heerden, E.

    2004-12-01

    This NSF-funded research experience for undergraduates (REU) took place in South Africa, where gold mines provided outstanding field sites to investigate biogeochemical processes in deep subsurface environments. Underrepresented minorities were encouraged to participate. Cross-disciplinary training was a major ambition for this REU Site: Biogeochemical Educational Experiences - South Africa. Students were selected from diverse academic disciplines (biology, chemistry, and geology) to participate in this interdisciplinary research program. Research projects included characterizing microbial communities with molecular and biochemical techniques, cultivating microorganisms, utilizing geochemical and isotopic parameters to constrain nutrient cycling in groundwater, investigating extreme enzymes and examining functional genes. During the REU, students collected biofilms and fissure water emanating from gas-rich boreholes in 2-3 km deep mines and performed laboratory research in teams under joint mentorship of U.S. and South African scientists. Research teams consisted of three to five students with at least one student from each country and at least two of the disciplines represented. Team membership reflected students' ranking of their choices among mentor-proposed projects. The REU encouraged students to increase scientific knowledge across disciplines, improve oral and written communication skills, and explore cultural and international challenges for scientific research in the global community. Each research team presented oral progress reports to the other research teams to provide communication skill development and to provide a forum for data exchange and interpretation among the various disciplines. Oral communication training culminated in a public presentation by each team at a university/industry science symposium. Mentors reviewed students' writing skills as they prepared text on experimental design, research findings, data interpretation, and literature

  7. Enhancing Student International Awareness and Global Competency through Compact International Experience Courses

    NASA Astrophysics Data System (ADS)

    Jacobitz, Frank; Schubert, Thomas

    2013-11-01

    Short-term, study-abroad, elective engineering courses were developed in order to raise the international awareness and global competency of engineering students. These Compact International Experience (CIE) courses were taught in response to a strong student desire for engineering study abroad courses and an effort by the home institution to internationalize its curriculum. An assessment of repeat offerings of two three-semester-unit courses on Topics in Fluid Mechanics and Advanced Electronic Circuit Design in a three-week time frame in France and Australia was performed. The goals of the two CIE courses are an effective teaching of their respective technical content as well as a student understanding of the cultural environment and the impact of engineering solutions from a global and societal viewpoint. In the repeat offerings, increased interaction with local industry was an additional goal. The CIE courses were assessed through surveys completed at the beginning and end of the courses, weekly student reflection papers, course evaluations, and formalized instructor observations. Based on the assessment performed, the two CIE courses have been found to be a valuable approach in the delivery of engineering technical electives combined with an international experience.

  8. Mathematical analysis for internal filtration of convection-enhanced high-flux hemodialyzer.

    PubMed

    Lee, Jung Chan; Lee, Kyungsoo; Kim, Hee Chan

    2012-10-01

    Structural modifications using a conventional hemodialyzer improved the internal filtration and clearance of middle molecular weight wastes by enhanced convection effect. In this study, we employed a mathematical model describing the internal filtration rate as well as the hemodynamic and hematologic parameters in highflux dialyzer to interpret the previous reported experimental results. Conventional high-flux hemodialysis and convection-enhanced high-flux hemodialysis were configured in the mathematical forms and integrated into the iterative numerical method to predict the internal filtration phenomena inside the dialyzers during dialysis. The distributions of blood pressure, dialysate pressure, oncotic pressure, blood flow rates, dialysate flow rates, local ultrafiltration, hematocrit, protein concentration and blood viscosity along the axial length of dialyzer were calculated in order to estimate the internal filtration volume. The results show that the filtration volumes by internal filtration is two times higher in a convection-enhanced high-flux hemodialyzer than in a conventional high-flux hemodialzer and explains the experimental result of improved clearance of middle molecular size waste in convection-enhanced high-flux hemodialyzer.

  9. Enhancing the Interpretability of the Overall Results of an International Test of English-Language Proficiency

    ERIC Educational Resources Information Center

    Papageorgiou, Spiros; Morgan, Rick; Becker, Valerie

    2015-01-01

    The purpose of this study was to enhance the meaning of the scores of an English-language test by developing performance levels and descriptors for reporting overall test performance. The levels and descriptors were intended to accompany the total scale scores of TOEFL Junior® Standard, an international test of English as a second/foreign…

  10. Internal Quality Assurance--Enhancing Quality Culture. ENQA Workshop Report 16

    ERIC Educational Resources Information Center

    ENQA (European Association for Quality Assurance in Higher Education), 2010

    2010-01-01

    The European Association for Quality Assurance in Higher Education (ENQA), in cooperation with the Quality Assurance Agency (QAA, UK), organised a seminar on theme "Internal Quality Assurance--Enhancing quality culture" which was held on 8-9 June, 2010 in London, United Kingdom. The seminar marked the fourth annual meeting of the ENQA IQA Group…

  11. Enhancing the Profile of Teachers as Curriculum Decision-Makers: Some International Perspectives.

    ERIC Educational Resources Information Center

    Macpherson, Ian; Brooker, Ross; Aspland, Tania; Elliott, Bob

    This paper presents information from a series of preliminary asynchronous international conversations across four cultural contexts that focus on enhancing the profile of teachers in curriculum decision making. The paper challenges education systems to match the rhetoric about the place of teachers in curriculum decision making with curriculum…

  12. Internal quantum efficiency enhancement of GaInN/GaN quantum-well structures using Ag nanoparticles

    SciTech Connect

    Iida, Daisuke; Fadil, Ahmed Ou, Yiyu; Kopylov, Oleksii; Ou, Haiyan; Chen, Yuntian; Iwaya, Motoaki; Takeuchi, Tetsuya; Kamiyama, Satoshi; Akasaki, Isamu

    2015-09-15

    We report internal quantum efficiency enhancement of thin p-GaN green quantum-well structure using self-assembled Ag nanoparticles. Temperature dependent photoluminescence measurements are conducted to determine the internal quantum efficiency. The impact of excitation power density on the enhancement factor is investigated. We obtain an internal quantum efficiency enhancement by a factor of 2.3 at 756 W/cm{sup 2}, and a factor of 8.1 at 1 W/cm{sup 2}. A Purcell enhancement up to a factor of 26 is estimated by fitting the experimental results to a theoretical model for the efficiency enhancement factor.

  13. Measured Wavelength-Dependent Absorption Enhancement of Internally Mixed Black Carbon with Absorbing and Nonabsorbing Materials.

    PubMed

    You, Rian; Radney, James G; Zachariah, Michael R; Zangmeister, Christopher D

    2016-08-01

    Optical absorption spectra of laboratory generated aerosols consisting of black carbon (BC) internally mixed with nonabsorbing materials (ammonium sulfate, AS, and sodium chloride, NaCl) and BC with a weakly absorbing brown carbon surrogate derived from humic acid (HA) were measured across the visible to near-IR (550 to 840 nm). Spectra were measured in situ using a photoacoustic spectrometer and step-scanning a supercontinuum laser source with a tunable wavelength and bandwidth filter. BC had a mass-specific absorption cross section (MAC) of 7.89 ± 0.25 m(2) g(-1) at λ = 550 nm and an absorption Ångström exponent (AAE) of 1.03 ± 0.09 (2σ). For internally mixed BC, the ratio of BC mass to the total mass of the mixture was chosen as 0.13 to mimic particles observed in the terrestrial atmosphere. The manner in which BC mixed with each material was determined from transmission electron microscopy (TEM). AS/BC and HA/BC particles were fully internally mixed, and the BC was both internally and externally mixed for NaCl/BC particles. The AS/BC, NaCl/BC, and HA/BC particles had AAEs of 1.43 ± 0.05, 1.34 ± 0.06, and 1.91 ± 0.05, respectively. The observed absorption enhancement of mixed BC relative to the pure BC was wavelength dependent for AS/BC and decreased from 1.5 at λ = 550 nm with increasing wavelength while the NaCl/BC enhancement was essentially wavelength independent. For HA/BC, the enhancement ranged from 2 to 3 and was strongly wavelength dependent. Removal of the HA absorption contribution to enhancement revealed that the enhancement was ≈1.5 and independent of wavelength. PMID:27359341

  14. Next Generation Safeguards Initiative Workshop on Enhanced Recruiting for International Safeguards

    SciTech Connect

    Pepper,S.; Rosenthal, M.; Fishbone, L.; Occhiogrosso, D.; Carroll, C.; Dreicer, M.; Wallace, R.; Rankhauser, J.

    2008-10-22

    In 2007, the National Nuclear Security Administration's Office of Nonproliferation and International Security (NA-24) completed a yearlong review of the challenges facing the international safeguards system today and over the next 25 years. The study found that without new investment in international safeguards, the U.S. safeguards technology base, and our ability to support International Atomic Energy Agency (IAEA) safeguards, will continue to erode and soon may be at risk. To reverse this trend, the then U.S. Secretary of Energy, Samuel Bodman, announced at the 2007 IAEA General Conference that the Department of Energy (DOE) would launch the Next Generation Safeguards Initiative (NGSI). He stated 'IAEA safeguards must be robust and capable of addressing proliferation threats. Full confidence in IAEA safeguards is essential for nuclear power to grow safely and securely. To this end, the U.S. Department of Energy will seek to ensure that modern technology, the best scientific expertise, and adequate resources are available to keep pace with expanding IAEA responsibilities.' To meet this goal, the NGSI objectives include the recruitment of international safeguards experts to work at the U.S. national laboratories and to serve at the IAEA's headquarters. Part of the latter effort will involve enhancing our existing efforts to place well-qualified Americans in a sufficient number of key safeguards positions within the IAEA's Department of Safeguards. Accordingly, the International Safeguards Project Office (ISPO) at Brookhaven National Laboratory (BNL) hosted a Workshop on Enhanced Recruiting for International Safeguards (ERIS) on October 22 and 23, 2008. The ISPO used a workshop format developed earlier with Sonalysts, Inc., that was followed at the U.S. Support Program's (USSP's) technology road-mapping sessions. ISPO invited participants from the U.S. DOE, the IAEA, the U.S. national laboratories, private industry, academia, and professional societies who either

  15. Enhanced protein internalization and efficient endosomal escape using polyampholyte-modified liposomes and freeze concentration.

    PubMed

    Ahmed, Sana; Fujita, Satoshi; Matsumura, Kazuaki

    2016-09-21

    Here we show a new strategy for efficient freeze concentration-mediated cytoplasmic delivery of proteins, obtained via the endosomal escape property of polyampholyte-modified liposomes. The freeze concentration method successfully induces the efficient internalization of proteins simply by freezing cells with protein and nanocarrier complexes. However, the mechanism of protein internalization remains unclear. Here, we designed a novel protein delivery carrier by modifying liposomes through incorporating hydrophobic polyampholytes therein. These complexes were characterized for particle size, encapsulation efficiency, and cytotoxicity. Flow cytometry and microscopic analysis showed that the adsorption and internalization of protein-loaded polyampholyte-modified liposomes after freezing were enhanced compared with that observed in unfrozen complexes. Inhibition studies demonstrated that the internalization mechanism differs between unmodified and polyampholyte-modified liposomes. Furthermore, polyampholyte-modified liposomes exhibited high efficacy in facilitating endosomal escape to enhance protein delivery to the cytoplasm with low toxicity. These results strongly suggest that the freeze concentration-based strategy could be widely utilised for efficient cargo delivery into the cytoplasm in vitro not only in cancer treatment but also for gene therapy as well. PMID:27439774

  16. Overexpressing OsPIN2 enhances aluminium internalization by elevating vesicular trafficking in rice root apex.

    PubMed

    Wu, Daoming; Shen, Hong; Yokawa, Ken; Baluška, František

    2015-11-01

    Aluminium (Al) sequestration is required for internal detoxification of Al in plant cells. In this study, it was found that the rice OsPIN2 overexpression line (OX1) had significantly reduced Al content in its cell wall and increased Al concentration in cell sap only in rice root tips relative to the wild-type (WT). In comparison with WT, OX1 reduced morin staining of cytosolic Al, enhanced FM 4-64 staining of membrane vesicular trafficking in root tip sections (0-1mm), and showed morin-FM 4-64 fluorescence overlap. Recovery treatment showed that cell-wall-bound Al was internalized into vacuoles via endocytic vesicular trafficking after removal of external Al. In this process, OX1 showed a higher rate of Al internalization than WT. Brefeldin A (BFA) interfered with vesicular trafficking and resulted in inhibition of Al internalization. This inhibitory effect could be alleviated when BFA was washed out, and the process of alleviation was slower in the cells of WT than in those of OX1. Microscopic observations revealed that, upon Al exposure, numerous multilamellar endosomes were detected between the cell wall and plasma membrane in the cells of OX1. Moreover, more vesicles enriched with Al complexes accumulated in the cells of OX1 than in those of WT, and these vesicles transformed into larger structures in the cells of OX1. Taken together, the data indicate that endocytic vesicular trafficking might contribute to Al internalization, and that overexpressing OsPIN2 enhances rice Al tolerance via elevated endocytic vesicular trafficking and Al internalization.

  17. Coherent nanocavity structures for enhancement in internal quantum efficiency of III-nitride multiple quantum wells

    SciTech Connect

    Kim, T.; Liu, B.; Smith, R.; Athanasiou, M.; Gong, Y.; Wang, T.

    2014-04-21

    A “coherent” nanocavity structure has been designed on two-dimensional well-ordered InGaN/GaN nanodisk arrays with an emission wavelength in the green spectral region, leading to a massive enhancement in resonance mode in the green spectra region. By means of a cost-effective nanosphere lithography technique, we have fabricated such a structure on an InGaN/GaN multiple quantum well epiwafer and have observed the “coherent” nanocavity effect, which leads to an enhanced spontaneous emission (SE) rate. The enhanced SE rate has been confirmed by time resolved photoluminescence measurements. Due to the coherent nanocavity effect, we have achieved a massive improvement in internal quantum efficiency with a factor of 88, compared with the as-grown sample, which could be significant to bridge the “green gap” in solid-state lighting.

  18. Next Generation Safeguards Initiative Workshop on Enhanced Recruiting for International Safeguards

    SciTech Connect

    Pepper,S.E.; Rosenthal, M.D.; Fishbone, L.G.; Occhogrosso, D.M.; Lockwood, D.; Carroll, C.J.; Dreicer, M.; Wallace, R.; Fankhauser, J.

    2009-07-12

    Brookhaven National Laboratory (BNL) hosted a Workshop on Enhanced Recruiting for International Safeguards October 22 and 23, 2008. The workshop was sponsored by DOE/NA-243 under the Next Generation Safeguards Initiative (NGSI). Placing well-qualified Americans in sufficient number and in key safeguards positions within the International Atomic Energy Agency’s (IAEA’s) Department of Safeguards is an important U.S. non-proliferation objective. The goal of the NGSI Workshop on Enhanced Recruiting for International Safeguards was to improve U.S. efforts to recruit U.S. citizens for IAEA positions in the Department of Safeguards. The participants considered the specific challenges of recruiting professional staff, safeguards inspectors, and managers. BNL’s International Safeguards Project Office invited participants from the U.S. Department of Energy, the IAEA, U.S. national laboratories, private industry, academia, and professional societies who are either experts in international safeguards or who understand the challenges of recruiting for technical positions. A final report for the workshop will be finalized and distributed in early 2009. The main finding of the workshop was the need for an integrated recruitment plan to take into account pools of potential candidates, various government and private agency stakeholders, the needs of the IAEA, and the NGSI human capital development plan. There were numerous findings related to and recommendations for maximizing the placement of U.S. experts in IAEA Safeguards positions. The workshop participants offered many ideas for increasing the pool of candidates and increasing the placement rate. This paper will provide details on these findings and recommendations

  19. Mannosylation of Virus-Like Particles Enhances Internalization by Antigen Presenting Cells

    PubMed Central

    Al-Barwani, Farah; Young, Sarah L.; Baird, Margaret A.; Larsen, David S.; Ward, Vernon K.

    2014-01-01

    Internalization of peptides by antigen presenting cells is crucial for the initiation of the adaptive immune response. Mannosylation has been demonstrated to enhance antigen uptake through mannose receptors, leading to improved immune responses. In this study we test the effect of surface mannosylation of protein-based virus-like particles (VLP) derived from Rabbit hemorrhagic disease virus (RHDV) on uptake by murine and human antigen presenting cells. A monomannoside and a novel dimannoside were synthesized and successfully conjugated to RHDV VLP capsid protein, providing approximately 270 mannose groups on the surface of each virus particle. VLP conjugated to the mannoside or dimannoside exhibited significantly enhanced binding and internalization by murine dendritic cells, macrophages and B cells as well as human dendritic cells and macrophages. This uptake was inhibited by the inclusion of mannan as a specific inhibitor of mannose specific uptake, demonstrating that mannosylation of VLP targets mannose receptor-based uptake. Consistent with mannose receptor-based uptake, partial retargeting of the intracellular processing of RHDV VLP was observed, confirming that mannosylation of VLP provides both enhanced uptake and modified processing of associated antigens. PMID:25122183

  20. Enhanced magneto-optical imaging of internal stresses in the removed surface layer

    NASA Astrophysics Data System (ADS)

    Agalidi, Yuriy; Kozhukhar, Pavlo; Levyi, Sergii; Turbin, Dmitriy

    2015-10-01

    The paper describes a software method of reconstructing the state of the removed surface layer by visualising internal stresses in the underlying layers of the sample. Such a problem typically needs to be solved as part of forensic investigation that aims to reveal original marking of a sample with removed surface layer. For example, one may be interested in serial numbers of weapons or vehicles that had the surface layer of metal removed from the number plate. Experimental results of studying gradient internal stress fields in ferromagnetic sample using the NDI method of magneto-optical imaging (MOI) are presented. Numerical modelling results of internal stresses enclosed in the surface marking region are analysed and compared to the experimental results of magneto-optical imaging (MOI). MOI correction algorithm intended for reconstructing internal stress fields in the removed surface layer by extracting stresses retained by the underlying layers is described. Limiting ratios between parameters of a marking font are defined for the considered correction algorithm. Enhanced recognition properties for hidden stresses left by marking symbols are experimentally verified and confirmed.

  1. Enhanced spectrophotometric determination of chromium (VI) with diphenylcarbazide using internal standard and derivative spectrophotometry.

    PubMed

    Wróbel, K; Wróbel, K; López-de-Alba, P L; López-Martínez, L

    1997-11-01

    In the present work, erioglaucine A was applied as internal standard to enhanced spectrophotometric determination of chromium (VI) with diphenylcarbazide. The following procedure was used: (1) addition of internal standard and formation of ion pairs of Cr (VI) with benzyltributylammonium bromide (BTAB) (sample volume 100 ml), (2) extraction to 10 ml of methylene chloride, (3) evaporation in nitrogen stream, and (4) redissolution in a micro-volume with addition of diphenylcarbazide for color development (final volume 200 mul). The preconcentration factor achieved was about 400 and it was shown that, using internal standard, the analytical errors due to sample treatment were reduced. The analytical signals for chromium and internal standard were obtained at 591.30 and 653.50 nm from first derivative spectra, normalized against (1)D(653.50nm). The analytical characteristics evaluated were: detection limit = 0.06 mug l(-1), quantification limit = 0.19 mug l(-1), precision for 1 mug l(-1) 14.2%, and for 10 mug l(-1) 3.2%, correlation coefficient of linear regression was 0.9985. The proposed procedure was applied to determination of chromium (VI) in tap water. Total chromium was determined by electrothermal atomic absorption spectrometry, the recovery of hexavalent chromium added was then evaluated and compared with the results of the proposed procedure. In this experiment, good agreement was obtained between results obtained by the two methods. PMID:18966962

  2. Enhancing social support, hardiness, and acculturation to improve mental health among Asian Indian international students.

    PubMed

    Kanekar, Amar; Sharma, Manoj; Atri, Ashutosh

    International students, upon relocation to a foreign country, undergo a major life event which can cause distress that can potentially affect their mental health. This study pilot tested an internet-based intervention to enhance the social support, hardiness, and acculturation among students of Asian Indian origin at a large midwestern university. A pretest-posttest randomized design was employed. The pretest was administered to 60 students who were then randomly assigned to experimental and comparison groups. The experimental group was offered online instruction about social support, hardiness, and acculturation through Blackboard over 2 months. The comparison group received an equivalent protocol based on general wellness. Repeated measures ANOVA was done which showed significant improvement in mental health variable (F(1, 37) = 4.768, p < 0.05). Recommendations for replicating such interventions in other groups of international students are presented. PMID:20353927

  3. Free nitrous acid pretreatment of wasted activated sludge to exploit internal carbon source for enhanced denitrification.

    PubMed

    Ma, Bin; Peng, Yongzhen; Wei, Yan; Li, Baikun; Bao, Peng; Wang, Yayi

    2015-03-01

    Using internal carbon source contained in waste activated sludge (WAS) is beneficial for nitrogen removal from wastewater with low carbon/nitrogen ratio, but it is usually limited by sludge disintegration. This study presented a novel strategy based on free nitrous acid (FNA) pretreatment to intensify the release of organic matters from WAS for enhanced denitrification. During FNA pretreatment, soluble chemical oxygen demand (SCOD) production kept increasing when FNA increased from 0 to 2.04 mg HNO2-N/L. Compared with untreated WAS, the internal carbon source production increased by 50% in a simultaneous fermentation and denitrification reactor fed with WAS pretreated by FNA for 24 h at 2.04 mg HNO2-N/L. This also increased denitrification efficiency by 76% and sludge reduction by 87.5%. More importantly, greenhouse gas nitrous oxide production in denitrification was alleviated since more electrons could be provided by FNA pretreated WAS.

  4. Internal Flow Simulation of Enhanced Performance Solid Rocket Booster for the Space Transportation System

    NASA Technical Reports Server (NTRS)

    Ahmad, Rashid A.; McCool, Alex (Technical Monitor)

    2001-01-01

    An enhanced performance solid rocket booster concept for the space shuttle system has been proposed. The concept booster will have strong commonality with the existing, proven, reliable four-segment Space Shuttle Reusable Solid Rocket Motors (RSRM) with individual component design (nozzle, insulator, etc.) optimized for a five-segment configuration. Increased performance is desirable to further enhance safety/reliability and/or increase payload capability. Performance increase will be achieved by adding a fifth propellant segment to the current four-segment booster and opening the throat to accommodate the increased mass flow while maintaining current pressure levels. One development concept under consideration is the static test of a "standard" RSRM with a fifth propellant segment inserted and appropriate minimum motor modifications. Feasibility studies are being conducted to assess the potential for any significant departure in component performance/loading from the well-characterized RSRM. An area of concern is the aft motor (submerged nozzle inlet, aft dome, etc.) where the altered internal flow resulting from the performance enhancing features (25% increase in mass flow rate, higher Mach numbers, modified subsonic nozzle contour) may result in increased component erosion and char. To assess this issue and to define the minimum design changes required to successfully static test a fifth segment RSRM engineering test motor, internal flow studies have been initiated. Internal aero-thermal environments were quantified in terms of conventional convective heating and discrete phase alumina particle impact/concentration and accretion calculations via Computational Fluid Dynamics (CFD) simulation. Two sets of comparative CFD simulations of the RSRM and the five-segment (IBM) concept motor were conducted with CFD commercial code FLUENT. The first simulation involved a two-dimensional axi-symmetric model of the full motor, initial grain RSRM. The second set of analyses

  5. Enhanced solar energy absorption by internally-mixed black carbon in snow grains

    NASA Astrophysics Data System (ADS)

    Flanner, M. G.; Liu, X.; Zhou, C.; Penner, J. E.; Jiao, C.

    2012-05-01

    Here we explore light absorption by snowpack containing black carbon (BC) particles residing within ice grains. Basic considerations of particle volumes and BC/snow mass concentrations show that there are generally 0.05-109 BC particles for each ice grain. This suggests that internal BC is likely distributed as multiple inclusions within ice grains, and thus the dynamic effective medium approximation (DEMA) (Chýlek and Srivastava, 1983) is a more appropriate optical representation for BC/ice composites than coated-sphere or standard mixing approximations. DEMA calculations show that the 460 nm absorption cross-section of BC/ice composites, normalized to the mass of BC, is typically enhanced by factors of 1.8-2.1 relative to interstitial BC. BC effective radius is the dominant cause of variation in this enhancement, compared with ice grain size and BC volume fraction. We apply two atmospheric aerosol models that simulate interstitial and within-hydrometeor BC lifecycles. Although only ~2% of the atmospheric BC burden is cloud-borne, 71-83% of the BC deposited to global snow and sea-ice surfaces occurs within hydrometeors. Key processes responsible for within-snow BC deposition are development of hydrophilic coatings on BC, activation of liquid droplets, and subsequent snow formation through riming or ice nucleation by other species and aggregation/accretion of ice particles. Applying deposition fields from these aerosol models in offline snow and sea-ice simulations, we calculate that 32-73% of BC in global surface snow resides within ice grains. This fraction is smaller than the within-hydrometeor deposition fraction because meltwater flux preferentially removes internal BC, while sublimation and freezing within snowpack expose internal BC. Incorporating the DEMA into a global climate model, we simulate increases in BC/snow radiative forcing of 43-86%, relative to scenarios that apply external optical properties to all BC. We show that snow metamorphism driven by

  6. Giant Enhancement of Internal Electric Field Boosting Bulk Charge Separation for Photocatalysis.

    PubMed

    Li, Jie; Cai, Lejuan; Shang, Jian; Yu, Ying; Zhang, Lizhi

    2016-06-01

    Incorporating carbon into Bi3 O4 Cl enhances its internal electric field by 126 times, which induces a bulk charge separation efficiency (ηbulk ) of 80%. This ultrahigh ηbulk value presents a state-of-the-art result in tuning the bulk charge separation. The generated C-doped Bi3 O4 Cl has a noble-metal- and electron-scavenger-free water-oxidation ability under visible light, which is difficult to achieve with most existing photocatalysts.

  7. Enhanced Solar Energy Absorption by Internally-mixed Black Carbon in Snow Grains

    SciTech Connect

    Flanner, M. G.; Liu, Xiaohong; Zhou, Cheng; Penner, Joyce E.; Jiao, C.

    2012-05-30

    Here we explore light absorption by snowpack containing black carbon (BC) particles residing within ice grains. Basic considerations of particle volumes and BC/snow mass concentrations show that there are generally 0:05-109 BC particles for each ice grain. This suggests that internal BC is likely distributed as multiple inclusions within ice grains, and thus the dynamic effective medium approximation (DEMA) (Chylek and Srivastava, 1983) is a more appropriate optical representation for BC/ice composites than coated-sphere or standard mixing approximations. DEMA calculations show that the 460 nm absorption cross-section of BC/ice composites, normalized to the mass of BC, is typically enhanced by factors of 1.8-2.1 relative to interstitial BC. BC effective radius is the dominant cause of variation in this enhancement, compared with ice grain size and BC volume fraction. We apply two atmospheric aerosol models that simulate interstitial and within-hydrometeor BC lifecycles. Although only {approx}2% of the atmospheric BC burden is cloud-borne, 71-83% of the BC deposited to global snow and sea-ice surfaces occurs within hydrometeors. Key processes responsible for within-snow BC deposition are development of hydrophilic coatings on BC, activation of liquid droplets, and subsequent snow formation through riming or ice nucleation by other species and aggregation/accretion of ice particles. Applying deposition fields from these aerosol models in offline snow and sea-ice simulations, we calculate that 32-73% of BC in global surface snow resides within ice grains. This fraction is smaller than the within-hydrometeor deposition fraction because meltwater flux preferentially removes internal BC, while sublimation and freezing within snowpack expose internal BC. Incorporating the DEMA into a global climate model, we simulate increases in BC/snow radiative forcing of 43-86%, relative to scenarios that apply external optical properties to all BC. We show that snow metamorphism

  8. Trapping of microwave radiation in hollow polypyrrole microsphere through enhanced internal reflection: a novel approach.

    PubMed

    Panigrahi, Ritwik; Srivastava, Suneel K

    2015-01-01

    In present work, spherical core (polystyrene, PS)/shell (polypyrrole, PPy) has been synthesized via in situ chemical oxidative copolymerization of pyrrole (Py) on the surface of sulfonated PS microsphere followed by the formation of hollow polypyrrole (HPPy) shell by dissolving PS inner core in THF. Thereafter, we first time established that such fabricated novel art of morphology acts as a conducting trap in absorbing electromagnetic (EM) wave by internal reflection. Further studies have been extended on the formation of its silver nanocomposites HPPy/Ag to strengthen our contention on this novel approach. Our investigations showed that electromagnetic interference (EMI) shielding efficiency (SE) of HPPy (34.5-6 dB) is significantly higher compared to PPy (20-5 dB) in the frequency range of 0.5-8 GHz due to the trapping of EM wave by internal reflection. We also observed that EMI shielding is further enhanced to 59-23 in 10 wt% Ag loaded HPPy/Ag-10. This is attributed to the simultaneous contribution of internal reflection as well as reflection from outer surface. Such high EMI shielding capacity using conducting polymers are rarely reported. PMID:25560384

  9. A computational study on the enhanced stabilization of aminophenol derivatives by internal hydrogen bonding

    NASA Astrophysics Data System (ADS)

    Gomes, José R. B.; Ribeiro da Silva, Manuel A. V.

    2006-05-01

    The stabilization of aminophenol derivatives and their radicals due to internal hydrogen bonding has been analyzed by means of density functional theory and by topological electron density analysis. The calculations have been carried out at the B3LYP level of theory, using several basis sets, and by means of the CBS-4M composite approach. A strong O-H⋯NH 2 hydrogen bond is found to stabilize the aminophenol with the lone-pair of the nitrogen atom co-planar with the aromatic ring, contrasting with the optimized structure found for aniline. The effect of electron donors and electron acceptors on the strength of the internal hydrogen bond is also analyzed. For one of the species studied, 2,6-diaminophenol, the computed O-H bond dissociation enthalpy is only 300 kJ/mol, the lowest value found so far for phenol and other compounds containing the O-H bond, almost 25 kJ/mol lower than those found experimentally for pyrogallol and for vitamin E. The explanation for such a small value comes from the enhanced stabilization of the corresponding radical species by internal hydrogen bonding, combined with a decrease of the steric effects caused by rotation of the amino groups.

  10. Trapping of microwave radiation in hollow polypyrrole microsphere through enhanced internal reflection: A novel approach

    PubMed Central

    Panigrahi, Ritwik; Srivastava, Suneel K.

    2015-01-01

    In present work, spherical core (polystyrene, PS)/shell (polypyrrole, PPy) has been synthesized via in situ chemical oxidative copolymerization of pyrrole (Py) on the surface of sulfonated PS microsphere followed by the formation of hollow polypyrrole (HPPy) shell by dissolving PS inner core in THF. Thereafter, we first time established that such fabricated novel art of morphology acts as a conducting trap in absorbing electromagnetic (EM) wave by internal reflection. Further studies have been extended on the formation of its silver nanocomposites HPPy/Ag to strengthen our contention on this novel approach. Our investigations showed that electromagnetic interference (EMI) shielding efficiency (SE) of HPPy (34.5-6 dB) is significantly higher compared to PPy (20-5 dB) in the frequency range of 0.5-8 GHz due to the trapping of EM wave by internal reflection. We also observed that EMI shielding is further enhanced to 59–23 in 10 wt% Ag loaded HPPy/Ag-10. This is attributed to the simultaneous contribution of internal reflection as well as reflection from outer surface. Such high EMI shielding capacity using conducting polymers are rarely reported. PMID:25560384

  11. Edesign: Primer and Enhanced Internal Probe Design Tool for Quantitative PCR Experiments and Genotyping Assays

    PubMed Central

    Kasahara, Naoko; Delobel, Diane; Hanami, Takeshi; Tanaka, Yuki; de Hoon, Michiel J. L.; Hayashizaki, Yoshihide; Usui, Kengo; Harbers, Matthias

    2016-01-01

    Analytical PCR experiments preferably use internal probes for monitoring the amplification reaction and specific detection of the amplicon. Such internal probes have to be designed in close context with the amplification primers, and may require additional considerations for the detection of genetic variations. Here we describe Edesign, a new online and stand-alone tool for designing sets of PCR primers together with an internal probe for conducting quantitative real-time PCR (qPCR) and genotypic experiments. Edesign can be used for selecting standard DNA oligonucleotides like for instance TaqMan probes, but has been further extended with new functions and enhanced design features for Eprobes. Eprobes, with their single thiazole orange-labelled nucleotide, allow for highly sensitive genotypic assays because of their higher DNA binding affinity as compared to standard DNA oligonucleotides. Using new thermodynamic parameters, Edesign considers unique features of Eprobes during primer and probe design for establishing qPCR experiments and genotyping by melting curve analysis. Additional functions in Edesign allow probe design for effective discrimination between wild-type sequences and genetic variations either using standard DNA oligonucleotides or Eprobes. Edesign can be freely accessed online at http://www.dnaform.com/edesign2/, and the source code is available for download. PMID:26863543

  12. Enhanced Spin Squeezing in Atomic Ensembles via Control of the Internal Spin States

    NASA Astrophysics Data System (ADS)

    Shojaee, Ezad; Norris, Leigh; Baragiola, Ben; Montano, Enrique; Hemmer, Daniel; Jessen, Poul; Deutsch, Ivan

    2015-05-01

    Abstract: We study the process by which the collective spin squeezing of an ensemble of Cesium atoms is enhanced by control of the internal spin state of the atoms. By increasing the initial atomic projection noise, one can enhance the Faraday interaction that entangles the atoms with a probe. The light acts as a quantum bus for creating atom-atom entanglement via measurement backaction. Further control can be used to transfer this entanglement to metrologically useful squeezing. We numerically simulate this protocol by a stochastic master equation, including QND measurement and optical pumping, which accounts for decoherence and transfer of coherences between magnetic sub-levels. We study the tradeoff between the enhanced entangling interaction and increased rates of decoherence for different initial state preparations. Under realistic conditions, we find that we can achieve squeezing with a ``CAT-State'' superpostion |F = 4, Mz = 4> + |F, Mz = -4> of ~ 9.9 dB and for the spin coherent state |F = 4, Mx = 4> of ~ 7.5 dB. The increased entanglement enabled by the CAT state preparation is partially, but not completely reduced by the increased fragility to decoherence. National Science Foundation.

  13. Carbon nanotubes enhance the internalization of drugs by cancer cells and decrease their chemoresistance to cytostatics.

    PubMed

    Mahmood, M; Xu, Y; Dantuluri, V; Mustafa, T; Zhang, Y; Karmakar, A; Casciano, D; Ali, S; Biris, A

    2013-02-01

    Etoposide is a semisynthetic, chemotherapeutic drug widely recommended to treat an extensive range of human cancers. Our studies indicate that, while etoposide is capable of killing human cancer cells, exposure to single-walled carbon nanotubes (SWCNTs) and etoposide results in enhanced cell death that appears to be synergistic and not merely additive. In this study, we used high pressure liquid chromatography and mass spectrometry to quantify the internal effective dose of etoposide when the human pancreatic cancer cell (PANC-1) was exposed to the combination of these agents. Our results unequivocally indicate that SWCNTs improve etoposide uptake and increase its capacity to kill cancer cells. We suggest that a combination of SWCNTs and etoposide may prove to be a more efficient chemotherapeutic protocol, especially because of the potential to lower toxic drug doses to levels that may be useful in decreasing adverse side effects, as well as in lowering the probability of inducing chemoresistance in exposed cancer cells.

  14. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

    PubMed Central

    Luo, Wenjie; Liu, Wencheng; Hu, Xiaoyan; Hanna, Mary; Caravaca, April; Paul, Steven M.

    2015-01-01

    Microglia have been shown to contribute to the clearance of brain amyloid β peptides (Aβ), the major component of amyloid plaques, in Alzheimer’s disease (AD). However, it is not known whether microglia play a similar role in the clearance of tau, the major component of neurofibrillary tangles (NFTs). We now report that murine microglia rapidly internalize and degrade hyperphosphorylated pathological tau isolated from AD brain tissue in a time-dependent manner in vitro. We further demonstrate that microglia readily degrade human tau species released from AD brain sections and eliminate NFTs from brain sections of P301S tauopathy mice. The anti-tau monoclonal antibody MC1 enhances microglia-mediated tau degradation in an Fc-dependent manner. Our data identify a potential role for microglia in the degradation and clearance of pathological tau species in brain and provide a mechanism explaining the potential therapeutic actions of passively administered anti-tau monoclonal antibodies. PMID:26057852

  15. Carbon nanotubes enhance the internalization of drugs by cancer cells and decrease their chemoresistance to cytostatics

    NASA Astrophysics Data System (ADS)

    Mahmood, M.; Xu, Y.; Dantuluri, V.; Mustafa, T.; Zhang, Y.; Karmakar, A.; Casciano, D.; Ali, S.; Biris, A.

    2013-02-01

    Etoposide is a semisynthetic, chemotherapeutic drug widely recommended to treat an extensive range of human cancers. Our studies indicate that, while etoposide is capable of killing human cancer cells, exposure to single-walled carbon nanotubes (SWCNTs) and etoposide results in enhanced cell death that appears to be synergistic and not merely additive. In this study, we used high pressure liquid chromatography and mass spectrometry to quantify the internal effective dose of etoposide when the human pancreatic cancer cell (PANC-1) was exposed to the combination of these agents. Our results unequivocally indicate that SWCNTs improve etoposide uptake and increase its capacity to kill cancer cells. We suggest that a combination of SWCNTs and etoposide may prove to be a more efficient chemotherapeutic protocol, especially because of the potential to lower toxic drug doses to levels that may be useful in decreasing adverse side effects, as well as in lowering the probability of inducing chemoresistance in exposed cancer cells.

  16. P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila

    PubMed Central

    Hoopfer, Eric D; Jung, Yonil; Inagaki, Hidehiko K; Rubin, Gerald M; Anderson, David J

    2015-01-01

    How brains are hardwired to produce aggressive behavior, and how aggression circuits are related to those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits that enhanced both inter-male aggression and courtship. Genetic intersections revealed that 8-10 P1 interneurons, previously thought to exclusively control male courtship, were sufficient to promote fighting. Optogenetic experiments indicated that P1 activation could promote aggression at a threshold below that required for wing extension. P1 activation in the absence of wing extension triggered persistent aggression via an internal state that could endure for minutes. High-frequency P1 activation promoted wing extension and suppressed aggression during photostimulation, whereas aggression resumed and wing extension was inhibited following photostimulation offset. Thus, P1 neuron activation promotes a latent, internal state that facilitates aggression and courtship, and controls the overt expression of these social behaviors in a threshold-dependent, inverse manner. DOI: http://dx.doi.org/10.7554/eLife.11346.001 PMID:26714106

  17. Plasmon Enhanced Internal Photoemission in Antenna-Spacer-Mirror Based Au/TiO₂ Nanostructures.

    PubMed

    Fang, Yurui; Jiao, Yang; Xiong, Kunli; Ogier, Robin; Yang, Zhong-Jian; Gao, Shiwu; Dahlin, Andreas B; Käll, Mikael

    2015-06-10

    Emission of photoexcited hot electrons from plasmonic metal nanostructures to semiconductors is key to a number of proposed nanophotonics technologies for solar harvesting, water splitting, photocatalysis, and a variety of optical sensing and photodetector applications. Favorable materials and catalytic properties make systems based on gold and TiO2 particularly interesting, but the internal photoemission efficiency for visible light is low because of the wide bandgap of the semiconductor. We investigated the incident photon-to-electron conversion efficiency of thin TiO2 films decorated with Au nanodisk antennas in an electrochemical circuit and found that incorporation of a Au mirror beneath the semiconductor amplified the photoresponse for light with wavelength λ = 500-950 nm by a factor 2-10 compared to identical structures lacking the mirror component. Classical electrodynamics simulations showed that the enhancement effect is caused by a favorable interplay between localized surface plasmon excitations and cavity modes that together amplify the light absorption in the Au/TiO2 interface. The experimentally determined internal quantum efficiency for hot electron transfer decreases monotonically with wavelength, similar to the probability for interband excitations with energy higher than the Schottky barrier obtained from a density functional theory band structure simulation of a thin Au/TiO2 slab.

  18. P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila.

    PubMed

    Hoopfer, Eric D; Jung, Yonil; Inagaki, Hidehiko K; Rubin, Gerald M; Anderson, David J

    2015-01-01

    How brains are hardwired to produce aggressive behavior, and how aggression circuits are related to those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits that enhanced both inter-male aggression and courtship. Genetic intersections revealed that 8-10 P1 interneurons, previously thought to exclusively control male courtship, were sufficient to promote fighting. Optogenetic experiments indicated that P1 activation could promote aggression at a threshold below that required for wing extension. P1 activation in the absence of wing extension triggered persistent aggression via an internal state that could endure for minutes. High-frequency P1 activation promoted wing extension and suppressed aggression during photostimulation, whereas aggression resumed and wing extension was inhibited following photostimulation offset. Thus, P1 neuron activation promotes a latent, internal state that facilitates aggression and courtship, and controls the overt expression of these social behaviors in a threshold-dependent, inverse manner.

  19. Plasmon Enhanced Internal Photoemission in Antenna-Spacer-Mirror Based Au/TiO₂ Nanostructures.

    PubMed

    Fang, Yurui; Jiao, Yang; Xiong, Kunli; Ogier, Robin; Yang, Zhong-Jian; Gao, Shiwu; Dahlin, Andreas B; Käll, Mikael

    2015-06-10

    Emission of photoexcited hot electrons from plasmonic metal nanostructures to semiconductors is key to a number of proposed nanophotonics technologies for solar harvesting, water splitting, photocatalysis, and a variety of optical sensing and photodetector applications. Favorable materials and catalytic properties make systems based on gold and TiO2 particularly interesting, but the internal photoemission efficiency for visible light is low because of the wide bandgap of the semiconductor. We investigated the incident photon-to-electron conversion efficiency of thin TiO2 films decorated with Au nanodisk antennas in an electrochemical circuit and found that incorporation of a Au mirror beneath the semiconductor amplified the photoresponse for light with wavelength λ = 500-950 nm by a factor 2-10 compared to identical structures lacking the mirror component. Classical electrodynamics simulations showed that the enhancement effect is caused by a favorable interplay between localized surface plasmon excitations and cavity modes that together amplify the light absorption in the Au/TiO2 interface. The experimentally determined internal quantum efficiency for hot electron transfer decreases monotonically with wavelength, similar to the probability for interband excitations with energy higher than the Schottky barrier obtained from a density functional theory band structure simulation of a thin Au/TiO2 slab. PMID:25938263

  20. ELiXIR—Solid-State Luminaire With Enhanced Light Extraction by Internal Reflection

    NASA Astrophysics Data System (ADS)

    Allen, Steven C.; Steckl, Andrew J.

    2007-06-01

    A phosphor-converted light-emitting diode (pcLED) luminaire featuring enhanced light extraction by internal reflection (ELiXIR) with efficacy of 60 lm/W producing 18 lumens of yellowish green light at 100 mA is presented. The luminaire consists of a commercial blue high power LED, a polymer hemispherical shell lens with interior phosphor coating, and planar aluminized reflector. High extraction efficiency of the phosphor-converted light is achieved by separating the phosphor from the LED and using internal reflection to steer the light away from lossy reflectors and the LED package and out of the device. At 10 and 500 mA, the luminaire produces 2.1 and 66 lumens with efficacies of 80 and 37 lm/W, respectively. Technological improvements over existing commercial LEDs, such as more efficient pcLED packages or, alternatively, higher efficiency green or yellow for color mixing, will be essential to achieving 150 200 lm/W solid-state lighting. Advances in both areas are demonstrated.

  1. Partnering International Universities to Enhance Climate Literacy through Interdisciplinary, Cross-Cultural Learning

    NASA Astrophysics Data System (ADS)

    North, L. A.; Polk, J.; Strenecky, B.

    2015-12-01

    The climate change phenomenon will present complex, far-reaching challenges and opportunities, which will require leaders well-versed in interdisciplinary learning and international understanding. In an effort to develop the next generation of future leaders prepared for these challenges and opportunities, faculty from Western Kentucky University (WKU) and the University of Akureyri (UNAK), Iceland partnered to co-teach a course in climate change science and communication in Iceland. Students from both Institutions participated in the course to further enhance the cross-learning opportunity presented to the students. The 11-day course stationed out of three cities in Iceland, including Reykjavík, Vik, and Akureyri, the Icelandic gateway to the Arctic. In addition to undertaking field experiences such as hiking on glaciers, exploring ice caves, and touring geothermal plants, the group also hosted forums to discuss climate change with members of the Icelandic community, and completed The $100 Solution™ service-learning projects. A culminating point of the study abroad experience was a presentation by the students to persons from the University of Akureyri and representatives from the neighboring Icelandic communities about what they had learned about climate change science and communication during their travels. Through this experience, students were able to share their knowledge, which in turn gave them a deeper understanding of the issues they were learning throughout the study abroad program. In short, the program combined interdisciplinary learning, service-learning, and international understanding toward the goal of preparing the leaders of tomorrow with the skills to address climate change challenges.

  2. Enhancing International Research and Development-Project Activity on University Campuses: Insights from U.S. Senior International Officers

    ERIC Educational Resources Information Center

    Koehn, Peter H.; Deardorff, Darla K.; Bolognese, Kerry D.

    2011-01-01

    In the interconnected world of the UN Decade of Education for Sustainable Development, the ability of higher-education institutions to contribute to and benefit from international research undertakings, sustainable-development-project activity, and capacity-building endeavors requires transnational involvement. While the potential benefits are…

  3. Heat transfer enhancement by a multilobe vortex generator in internally finned tubes

    SciTech Connect

    Tsui, Y.Y.; Leu, S.W.

    1999-04-01

    A three-dimensional computational method is employed to study the flow and heat transfer in internally finned tubes with a multilobe vortex generator inserted. Governing equations are discretized using the finite volume method. The irregular lobe geometry is treated using curvilinear nonstaggered grids. The linear interpolation method is adopted to calculate face velocities. The results show that secondary flows induced by the lobes are transformed to become axial vortices downstream of the vortex generator. As a consequence of the transport by the vortex flow, the core flow is moved to the fins and the tube wall, while the wall flow moves to the core. In this way, both heat transfer and flow mixing are enhanced. When the fin height is increased, the axial vortex is more restricted in the centerline region, and the strength of the vortex flow, represented by circulation, is decreased. In turn, the total pressure loss is also decreased. However, the heat transfer increases with fin height. Consequently, efficiency is greatly promoted.

  4. Enhanced attachment of Bradyrhizobium japonicum to soybean through reduced root colonization of internally seedborne microorganisms.

    PubMed

    Oehrle, N W; Karr, D B; Kremer, R J; Emerich, D W

    2000-07-01

    Internally seedborne microorganisms are those surviving common surface sterilization procedures. Such microbes often colonize the radicle surface of a germinating soybean (Glycine max) seed, introducing an undefined parameter into studies on attachment and infection by Bradyrhizobium japonicum. Bacterial isolates from surface-sterilized soybean seed, cv. Williams 82 and cv. Maverick, used in our studies, were identified as Agrobacterium radiobacter, Aeromonas sp., Bacillus spp., Chryseomonas luteola, Flavimonas oryzihabitans, and Sphingomonas paucimobilis. Growth of these microbes during seed germination was reduced by treating germinating seeds with 500 micrograms/mL penicillin G. The effects of this antibiotic on seedling development and on B. japonicum 2143 attachment, nodulation, and nitrogen fixation are reported here. Penicillin G treatment of seeds did not reduce seed germination or root tip growth, or affect seedling development. No differences in nodulation kinetics, nitrogen fixation onset or rates were observed. However, the number of B. japonicum attached to treated intact seedlings was enhanced 200-325%, demonstrating that other root-colonizing bacteria can interfere with rhizobial attachment. Penicillin G treatment of soybean seedlings can be used to reduce the root colonizing microbes, which introduce an undefined parameter into studies of attachment of B. japonicum to the soybean root, without affecting plant development.

  5. Enhanced gene transfection by photochemical internalization of protomine sulfate/DNA complexes

    NASA Astrophysics Data System (ADS)

    Hirschberg, Henry; Mathews, Marlon B.; Shih, En-Chung; Madsen, Steen J.; Kwon, Young Jik

    2012-02-01

    Introduction: One of many limitations for cancer gene therapy is the inability of the therapeutic gene to transfect a sufficient number of tumor cells. Photochemical internalization (PCI) is a photodynamic therapy-based approach for improving the delivery of macromolecules and genes into the cell cytosol. The utility of PCI for the delivery of the GFP indicator gene on the same plasmid as a tumor suppressor gene (PTEN) was investigated in monolayers of U251 human glioma cells. Materials and Methods: U251 monolayers were incubated in AlPcS2a for 18 h. The monolayers were incubated with non-viral vectors for either 4 or 18 hrs. In all cases, light treatment was performed with a diode laser at a wavelength of 670 nm. The non-viral transfection agents, branched PEI or protomine sulfate (PS), were used with the plasmid construct (GFP-PTEN). Results: PS was much less toxic to the gliomas cells compared to BPEI but was highly inefficient at gene transfection. PCI resulted in a 5-10 fold increase in GFP protein expression compared to controls. Conclusions: Collectively, the results suggest that AlPcS2a-mediated PCI can be used to enhance transfection of tumor suppressor genes in glioma cells.

  6. Surface modification of PLGA nanoparticles by carbopol to enhance mucoadhesion and cell internalization.

    PubMed

    Surassmo, Suvimol; Saengkrit, Nattika; Ruktanonchai, Uracha Rungsardthong; Suktham, Kunat; Woramongkolchai, Noppawan; Wutikhun, Tuksadon; Puttipipatkhachorn, Satit

    2015-06-01

    Mucoadhesive poly (lactic-co-glycolic acid) (PLGA) nanoparticles having a modified shell-matrix derived from polyvinyl alcohol (PVA) and Carbopol (CP), a biodegradable polymer coating, to improve the adhesion and cell transfection properties were developed. The optimum formulations utilized a CP concentration in the range of 0.05-0.2%w/v, and were formed using modified emulsion-solvent evaporation technique. The resulting CP-PLGA nanoparticles were characterized in terms of their physical and chemical properties. The absorbed CP on the PLGA shell-matrix was found to affect the particle size and surface charge, with 0.05% CP giving rise to smooth spherical particles (0.05CP-PLGA) with the smallest size (285.90 nm), and strong negative surface charge (-25.70 mV). The introduction of CP results in an enhancement of the mucoadhesion between CP-PLGA nanoparticles and mucin particles. In vitro cell internalization studies highlighted the potential of 0.05CP-PLGA nanoparticles for transfection into SiHa cells, with uptake being time dependent. Additionally, cytotoxicity studies of CP-PLGA nanoparticles against SiHa cancer cells indicated that low concentrations of the nanoparticles were non-toxic to cells (cell viability >80%). From the various formulations studied, 0.05CP-PLGA nanoparticles proved to be the optimum model carrier having the required mucoadhesive profile and could be an alternative therapeutic efficacy carrier for targeted mucosal drug delivery systems with biodegradable polymer.

  7. Identifying Areas of Tension in the Field of Technology-Enhanced Learning: Results of an International Delphi Study

    ERIC Educational Resources Information Center

    Plesch, Christine; Kaendler, Celia; Rummel, Nikol; Wiedmann, Michael; Spada, Hans

    2013-01-01

    Despite steady progress in research in technology-enhanced learning (TEL), the translation of research findings and technology into educational practices falls short of expectations. We present five Areas of Tension which were identified and evaluated in an international Delphi study on TEL. These tensions might impede a more comprehensive…

  8. Assessment of Intern's Performance: A Key To Enhance School Leader Preparation Programs.

    ERIC Educational Resources Information Center

    Ovando, Martha N.

    This paper examines the assessment of interns' performance in a university-based internship program. A group of 46 school administrators (mainly principals) who supervised interns in a variety of school settings as part of a university-based school leader preparation program completed the Assessment of Interns' Performance form. The assessment was…

  9. Surface modification of PLGA nanoparticles by carbopol to enhance mucoadhesion and cell internalization.

    PubMed

    Surassmo, Suvimol; Saengkrit, Nattika; Ruktanonchai, Uracha Rungsardthong; Suktham, Kunat; Woramongkolchai, Noppawan; Wutikhun, Tuksadon; Puttipipatkhachorn, Satit

    2015-06-01

    Mucoadhesive poly (lactic-co-glycolic acid) (PLGA) nanoparticles having a modified shell-matrix derived from polyvinyl alcohol (PVA) and Carbopol (CP), a biodegradable polymer coating, to improve the adhesion and cell transfection properties were developed. The optimum formulations utilized a CP concentration in the range of 0.05-0.2%w/v, and were formed using modified emulsion-solvent evaporation technique. The resulting CP-PLGA nanoparticles were characterized in terms of their physical and chemical properties. The absorbed CP on the PLGA shell-matrix was found to affect the particle size and surface charge, with 0.05% CP giving rise to smooth spherical particles (0.05CP-PLGA) with the smallest size (285.90 nm), and strong negative surface charge (-25.70 mV). The introduction of CP results in an enhancement of the mucoadhesion between CP-PLGA nanoparticles and mucin particles. In vitro cell internalization studies highlighted the potential of 0.05CP-PLGA nanoparticles for transfection into SiHa cells, with uptake being time dependent. Additionally, cytotoxicity studies of CP-PLGA nanoparticles against SiHa cancer cells indicated that low concentrations of the nanoparticles were non-toxic to cells (cell viability >80%). From the various formulations studied, 0.05CP-PLGA nanoparticles proved to be the optimum model carrier having the required mucoadhesive profile and could be an alternative therapeutic efficacy carrier for targeted mucosal drug delivery systems with biodegradable polymer. PMID:25937384

  10. Use of Myometrium as an Internal Reference for Endometrial and Cervical Cancer on Multiphase Contrast-Enhanced MRI

    PubMed Central

    Lin, Chia-Ni; Liao, Yu-San; Chen, Wen-Chang; Wang, Yue-Sheng; Lee, Li-Wen

    2016-01-01

    Background Myometrial smooth muscle is normally within the field of view for the gynecological imaging. This study aimed to investigate the use of normal myometrium as an internal reference for endometrial and cervical cancer during multiphase contrast-enhanced magnetic resonance imaging (MCE-MRI) and to explore whether this information regarding tumor enhancement relative to the myometrium could be used to discriminate between endometrial and cervical cancer. Methods MRI images, before and after contrast enhancement, were analyzed in newly diagnosed cervical (n = 18) and endometrial cancer (n = 19) patients. Signal intensities (SIs) from tumor tissue and non-neoplastic myometrium were measured using imaging software. Results The relative signal for cervical cancer was approximately 30% higher than that of endometrial cancer after contrast administration. The area under receiver operating characteristic curve for SI, relative signal enhancement, and tumor to myometrium contrast ratio (as used to discriminate between cervical cancer and endometrial cancer) was 0.7807, 0.7456 and 0.7895, respectively. There was no difference in SI of the normal myometrium between endometrial and cervical cancer patients prior to and after contrast administration. Using non-tumorous myometrium as an internal reference, the tumor to myometrium contrast ratio was significantly higher in tumor tissue from cervical cancer compared with that from endometrial cancer at 25 s post contrast enhancement (p = 0.0016), with an optimal sensitivity of 72.22% and specificity of 84.21%. Conclusion With SI normalized to baseline or normal myometrium, tumor tissue from cervical cancer patients showed significant hyperintensity compared with that of tumor tissue from endometrial cancer patients after contrast enhancement, yielding acceptable performance. The use of the myometrium as an internal reference may provide an alternative method to analyze MCE-MRI data. PMID:27326456

  11. Enhancement of internal ribosome entry site-mediated translation and replication of hepatitis C virus by PD98059

    SciTech Connect

    Murata, Takayuki; Hijikata, Makoto; Shimotohno, Kunitada . E-mail: kshimoto@virus.kyoto-u.ac.jp

    2005-09-15

    Translation initiation of hepatitis C virus (HCV) occurs in an internal ribosome entry site (IRES)-dependent manner. We found that HCV IRES-dependent protein synthesis is enhanced by PD98059, an inhibitor of the extracellular signal-regulated kinase (ERK) signaling pathway, while cellular cap-dependent translation was relatively unaffected by the compound. Treatment of cells with PD98059 allowed for robust HCV replication following cellular incubation with HCV-positive serum. Though the molecular mechanism underlying IRES enhancement remains elusive, PD98059 is a potent accelerator of HCV RNA replication.

  12. Enhancement of environment and resources engineering studies through an international cooperation network

    NASA Astrophysics Data System (ADS)

    Caporali, E.; Tuneski, A.

    2012-12-01

    , following the criteria and conditions for setting up a Joint Postgraduate Degree. The new second cycle degree courses are going to be activated in the academic year 2012/2012. Both the first and second cycle curricula, developed through the co-operation, exchange of know-how and expertise between partners, are based on the European Credit Transfer System and are in accordance with the Bologna Process. In DEREL a second objective is to implement a sustainable regional network aimed to offer lifelong learning seminars for environment and resources engineering education and training of interested stakeholders and organize workshops focused on strengthening the links in the knowledge triangle: environment education-innovation-research, with participation of postgraduate students, public services, enterprises and NGO's. Also, the good collaborative environment created, since 2005, with the project partners can be surely mentioned as an additional valuable objective of the two TEMPUS projects, enabling implementation of a sustainable international network for environment and resources engineering studies enhancement and development.

  13. Social Media Use to Enhance Internal Communication: Course Design for Business Students

    ERIC Educational Resources Information Center

    Young, Amy M.; Hinesly, Mary D.

    2014-01-01

    Organizations are increasingly using social media to improve their internal communication. When successfully implemented, such initiatives can have a dramatic impact on internal efficiency, team collaboration, innovation, organizational alignment, and cultural transformation. This article describes a course offered by the Ross School of Business,…

  14. Think Globally! Enhancing the International Student Experience with LibGuides

    ERIC Educational Resources Information Center

    Han, Ning; Hall, Susan L.

    2012-01-01

    Enrollment of international students in colleges and universities across the United States is growing. The relocation process can be arduous for international students as they face many barriers transitioning to a new environment. With retention as a key component in the success of academic institutions, what resources and services can academic…

  15. "Community Connections": A Programme to Enhance Domestic and International Students' Educational Experience

    ERIC Educational Resources Information Center

    Gresham, Ruth; Clayton, Veronica

    2011-01-01

    It has been widely acknowledged that an important indicator of a successful sojourn for international students is social integration into the host community. Despite seemingly regular opportunities to integrate, many international students report that their interactions with local residents remain superficial. The "Community Connections" programme…

  16. Enhancing Excellence and Equity in Schooling: Modality Theory, an International Perspective

    ERIC Educational Resources Information Center

    Chen, Hsin-Tzu; Ansalone, George

    2008-01-01

    This international research examines the learning style preferences of Taiwanese students by gender and age in an attempt to determine which of the five learning style stimuli (environmental, emotional, sociological, physiological and psychological) are more likely to be a factor in student academic success. Utilizing an international perspective,…

  17. Internal Audit: Does it Enhance Governance in the Australian Public University Sector?

    ERIC Educational Resources Information Center

    Christopher, Joe

    2015-01-01

    This study seeks to confirm if internal audit, a corporate control process, is functioning effectively in Australian public universities. The study draws on agency theory, published literature and best-practice guidelines to develop an internal audit evaluation framework. A survey instrument is thereafter developed from the framework and used as a…

  18. A Novel Cysteine Knot Protein for Enhancing Sperm Motility That Might Facilitate the Evolution of Internal Fertilization in Amphibians

    PubMed Central

    Yokoe, Misato; Takayama-Watanabe, Eriko; Saito, Yoko; Kutsuzawa, Megumi; Fujita, Kosuke; Ochi, Haruki; Nakauchi, Yuni; Watanabe, Akihiko

    2016-01-01

    Internal fertilization ensures successful reproduction of tetrapod vertebrates on land, although how this mode of reproduction evolved is unknown. Here, we identified a novel gene encoding sperm motility-initiating substance (SMIS), a key protein for the internal fertilization of the urodele Cynops pyrrhogaster by Edman degradation of an isolated protein and subsequent reverse transcription polymerase chain reaction. The SMIS gene encoded a 150 amino-acid sequence including the cysteine knot (CK) motif. No gene with substantial similarity to the SMIS was in the data bank of any model organisms. An active site of the SMIS was in the C-terminal region of the 2nd loop of CK motif. A synthetic peptide including the active site sequence bound to the midpiece and initiated/enhanced the circular motion of C. pyrrhogaster sperm, which allows penetration of the egg jelly specialized for the internal fertilization of this species. The synthetic peptide bound to whole sperm of Rhacophorus arboreus and enhanced the rotary motion, which is adapted to propel the sperm through egg coat matrix specialized for arboreal reproduction, while it bound to the tip of head and tail of Bufo japonicus sperm, and enhanced the vibratory motion, which is suited to sperm penetration through the egg jelly specialized for the reproduction of that species in freshwater. The polyclonal antibody against the active site of the SMIS specifically bound to egg coat matrix of R. arboreus. These findings suggest that diversification of amphibian reproductive modes accompanies the specialization of egg coat and the adaptation of sperm motility to penetrate the specialized egg coat, and SMIS acts as the sperm motility enhancer of anurans and urodeles that might facilitate to adaptively optimize sperm motility for allowing the establishment of internal fertilization. PMID:27579691

  19. A Novel Cysteine Knot Protein for Enhancing Sperm Motility That Might Facilitate the Evolution of Internal Fertilization in Amphibians.

    PubMed

    Yokoe, Misato; Takayama-Watanabe, Eriko; Saito, Yoko; Kutsuzawa, Megumi; Fujita, Kosuke; Ochi, Haruki; Nakauchi, Yuni; Watanabe, Akihiko

    2016-01-01

    Internal fertilization ensures successful reproduction of tetrapod vertebrates on land, although how this mode of reproduction evolved is unknown. Here, we identified a novel gene encoding sperm motility-initiating substance (SMIS), a key protein for the internal fertilization of the urodele Cynops pyrrhogaster by Edman degradation of an isolated protein and subsequent reverse transcription polymerase chain reaction. The SMIS gene encoded a 150 amino-acid sequence including the cysteine knot (CK) motif. No gene with substantial similarity to the SMIS was in the data bank of any model organisms. An active site of the SMIS was in the C-terminal region of the 2nd loop of CK motif. A synthetic peptide including the active site sequence bound to the midpiece and initiated/enhanced the circular motion of C. pyrrhogaster sperm, which allows penetration of the egg jelly specialized for the internal fertilization of this species. The synthetic peptide bound to whole sperm of Rhacophorus arboreus and enhanced the rotary motion, which is adapted to propel the sperm through egg coat matrix specialized for arboreal reproduction, while it bound to the tip of head and tail of Bufo japonicus sperm, and enhanced the vibratory motion, which is suited to sperm penetration through the egg jelly specialized for the reproduction of that species in freshwater. The polyclonal antibody against the active site of the SMIS specifically bound to egg coat matrix of R. arboreus. These findings suggest that diversification of amphibian reproductive modes accompanies the specialization of egg coat and the adaptation of sperm motility to penetrate the specialized egg coat, and SMIS acts as the sperm motility enhancer of anurans and urodeles that might facilitate to adaptively optimize sperm motility for allowing the establishment of internal fertilization. PMID:27579691

  20. Enhanced acoustic mode coupling resulting from an internal solitary wave approaching the shelfbreak in the South China Sea.

    PubMed

    Chiu, Linus Y S; Reeder, D Benjamin; Chang, Yuan-Ying; Chen, Chi-Fang; Chiu, Ching-Sang; Lynch, James F

    2013-03-01

    Internal waves and bathymetric variation create time- and space-dependent alterations in the ocean acoustic waveguide, and cause subsequent coupling of acoustic energy between propagating normal modes. In this paper, the criterion for adiabatic invariance is extended to the case of an internal solitary wave (ISW) encountering a sloping bathymetry (i.e., continental shelfbreak). Predictions based on the extended criterion for adiabatic invariance are compared to experimental observations from the Asian Seas International Acoustics Experiment. Using a mode 1 starter field, results demonstrate time-dependent coupling of mode 1 energy to higher adjacent modes, followed by abrupt coupling of mode 5-7 energy to nonadjacent modes 8-20, produces enhanced mode coupling and higher received levels downrange of the oceanographic and bathymetric features. Numerical simulations demonstrate that increasing ISW amplitude and seafloor slope enhance the coupling of energy to adjacent and nonadjacent modes. This enhanced coupling is the direct result of the simultaneous influence of the ISW and its proximity to the shelfbreak, and, compared to the individual effect of the ISW or shelfbreak, has the capacity to scatter 2-4 times the amount of acoustic energy from below the thermocline into the upper water column beyond the shelfbreak in realistic environments.

  1. Community Connections to Enhance Undergraduate International Business Education: An Example of Business Consulting Projects

    ERIC Educational Resources Information Center

    Annavarjula, Madan; Trifts, Jack W.

    2012-01-01

    Practical project experience as a means of augmenting traditional classroom learning has long been viewed as a value adding curricular exercise. While students participating in the projects gain valuable skills that will enhance their personal marketability, successful projects also benefit the client companies involved and help enhance the image…

  2. Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles

    SciTech Connect

    Polf, Jerimy C.; Gillin, Michael; Bronk, Lawrence F.; Driessen, Wouter H. P.; Arap, Wadih; Pasqualini, Renata

    2011-05-09

    The development and use of sensitizing agents to improve the effectiveness of radiotherapy have long been sought to improve our ability to treat cancer. In this letter, we have studied the relative biological effectiveness of proton beam radiotherapy on prostate tumor cells with and without internalized gold nanoparticles. The effectiveness of proton radiotherapy for the killing of prostate tumor cells was increased by approximately 15%-20% for those cells containing internalized gold nanoparticles.

  3. Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles

    NASA Astrophysics Data System (ADS)

    Polf, Jerimy C.; Bronk, Lawrence F.; Driessen, Wouter H. P.; Arap, Wadih; Pasqualini, Renata; Gillin, Michael

    2011-05-01

    The development and use of sensitizing agents to improve the effectiveness of radiotherapy have long been sought to improve our ability to treat cancer. In this letter, we have studied the relative biological effectiveness of proton beam radiotherapy on prostate tumor cells with and without internalized gold nanoparticles. The effectiveness of proton radiotherapy for the killing of prostate tumor cells was increased by approximately 15%-20% for those cells containing internalized gold nanoparticles.

  4. International mobility placements enable students and staff in Higher Education to enhance transversal and employability-related skills.

    PubMed

    Standley, Henrietta J

    2015-10-01

    Internationalization has commanded an ever-more prominent position in higher education over recent years, and is now firmly entrenched. While academia has long been outward looking-international research collaborations, conferences and student exchanges are well-established practices-it is relatively recently that internationalization has become a goal in its own right, rather than a consequence of normal academic activity. There are multiple interdependent drivers behind this: a focus on graduate employability and development of broad competencies and transferable skills in addition to subject-specific training, 'international awareness' being confirmed as a graduate attribute that is highly valued by employers, the availability of detailed information enabling prospective students to choose between Higher Education Institutions on the basis of their international opportunities and graduate employment rates, increasing competition between Institutions to attract the best students and to ascend national and international league tables, and (both driving and reflecting these trends) national policy frameworks. This minireview focuses on two aspects of internationalization of direct relevance to microbiology students and academic staff in a typical Higher Education Institution: student research placements overseas, and the impact of international mobility on teaching practice and the student experience. Practical strategies for developing intercultural awareness and enhancing employability are highlighted.

  5. International mobility placements enable students and staff in Higher Education to enhance transversal and employability-related skills.

    PubMed

    Standley, Henrietta J

    2015-10-01

    Internationalization has commanded an ever-more prominent position in higher education over recent years, and is now firmly entrenched. While academia has long been outward looking-international research collaborations, conferences and student exchanges are well-established practices-it is relatively recently that internationalization has become a goal in its own right, rather than a consequence of normal academic activity. There are multiple interdependent drivers behind this: a focus on graduate employability and development of broad competencies and transferable skills in addition to subject-specific training, 'international awareness' being confirmed as a graduate attribute that is highly valued by employers, the availability of detailed information enabling prospective students to choose between Higher Education Institutions on the basis of their international opportunities and graduate employment rates, increasing competition between Institutions to attract the best students and to ascend national and international league tables, and (both driving and reflecting these trends) national policy frameworks. This minireview focuses on two aspects of internationalization of direct relevance to microbiology students and academic staff in a typical Higher Education Institution: student research placements overseas, and the impact of international mobility on teaching practice and the student experience. Practical strategies for developing intercultural awareness and enhancing employability are highlighted. PMID:26347299

  6. Enhancing international earth science competence in natural hazards through 'geoNatHaz

    NASA Astrophysics Data System (ADS)

    Giardino, Marco; Clague, John J.

    2010-05-01

    "geoNatHaz" is a Transatlantic Exchange Partnership project (TEP 2009-2012) within the framework of the EU-Canada programme for co-operation in higher education, training, and youth. The project is structured to improve knowledge and skills required to assess and manage natural hazards in mountain regions. It provides student exchanges between European and Canadian universities in order to enhance international competence in natural hazard research. The university consortium is led by Simon Fraser University (Canada) and Università degli studi di Torino (Italy). Partner universities include the University of British Columbia, Queen's University, Università di Bologna, Université de Savoie, and the University of Athens. Université de Lausanne (Switzerland) supports the geoNatHaz advisory board through its bilateral agreements with Canadian partner universities. The geoNatHaz project promotes cross-cultural understanding and internationalization of university natural hazard curricula through common lectures, laboratory exercises, and field activities. Forty graduate students from the seven Canadian and European partner universities will benefit from the project between 2009 and 2012. Some students enrolled in graduate-level earth science and geologic engineering programs spend up to five months at the partner universities, taking courses and participating in research teams under the direction of project scientists. Other students engage in short-term (four-week) exchanges involving training in classic natural hazard case-studies in mountain regions of Canada and Europe. Joint courses are delivered in English, but complementary cultural activities are offered in the languages of the host countries. Supporting organizations offer internships and technical and scientific support. Students benefit from work-study programs with industry partners. Supporting organizations include government departments and agencies (Geological Survey of Canada; CNR-IRPI National

  7. An internal electron reservoir enhances catalytic CO2 reduction by a semisynthetic enzyme.

    PubMed

    Schneider, Camille R; Shafaat, Hannah S

    2016-08-01

    The development of an artificial metalloenzyme for CO2 reduction is described. The small-molecule catalyst [Ni(II)(cyclam)](2+) has been incorporated within azurin. Selectivity for CO generation over H(+) reduction is enhanced within the protein environment, while the azurin active site metal impacts the electrochemical overpotential and photocatalytic activity. The enhanced catalysis observed for copper azurin suggests an important role for intramolecular electron transfer, analogous to native CO2 reducing enzymes. PMID:27406946

  8. Time-resolved internal-electron-scattering effect of H2 + in enhanced ionization regions

    NASA Astrophysics Data System (ADS)

    Li, Yang; Zhou, Yueming; He, Mingrui; Li, Min; Lan, Pengfei; Lu, Peixiang

    2016-07-01

    We theoretically investigate the electron interference dynamics of H2 + in an intense infrared laser field. At intermediate internuclear distances, an interference fringe appears in the electron momentum distribution. By tracing the time evolution of the electron density, we identify an internal scattering channel of the electrons. The observed fringe is attributed to the interference between the internal scattered and direct photoelectrons. Our results reveal that the electron behaviors inside a molecule can be mapped onto the experimentally accessible photoelectron momentum spectra, suggesting a time-resolved way of probing the complex laser-driven electron dynamics on an attosecond time scale.

  9. International Experiences as Professional Development to Enhance Classroom Practice: Beyond Educational Tourism

    ERIC Educational Resources Information Center

    Johnson, John William, III

    2012-01-01

    Professional development of educators is a central feature in education reform efforts (Bredeson, 2000) and school improvement (Guskey & Huberman, 1995). The purpose of the study was to describe personal and professional gains from an international experience, notably the Fulbright-Hays Group Study Abroad Program, including new knowledge and…

  10. Enhancing Student Competency and Employability in International Business through Master's Dissertations

    ERIC Educational Resources Information Center

    Sinkovics, Rudolf R.; Richardson, Christopher; Lew, Yong Kyu

    2015-01-01

    A core component of International Business (IB) postgraduate programs around the world is the master's dissertation, which requires students to produce a written document, typically around 20,000 words in length, based on empirical research. While the dissertation is given considerable importance in such programs, often accounting for more than a…

  11. Enhancing International Postgraduates' Learning Experience with Online Peer Assessment and Feedback Innovation

    ERIC Educational Resources Information Center

    Chew, Esyin; Snee, Helena; Price, Trevor

    2016-01-01

    Internationalisation and assessment and feedback are one of the main research agenda in the UK higher education. The study reports the Higher Education Academy Economics Network-funded research for international students' experience with peer assessment and feedback innovation. The Vygotsky's Zone of Proximal Development (ZPD) theoretical…

  12. Strategies to Enhance Student Success: A Discourse Analysis of Academic Advice in International Student Handbooks

    ERIC Educational Resources Information Center

    Romerhausen, Nick J.

    2013-01-01

    As the population of international students continues to rise at U.S. colleges and universities, multiple academic obstacles pose barriers to success. Research on strategies of intervention has primarily included face-to-face interactions while an exploration of other assistance approaches is minimal in comparison. This study explored the role…

  13. Enhance Secondary & Post-Secondary Conservation Learning with International Guest Lectures

    ERIC Educational Resources Information Center

    Maehr, David S.; Widen, Per

    2004-01-01

    The significance of improving conservation education in the classroom with international guest lectures is presented and a survey on 14 Swedish students and 23 American students is conducted. Such survey evaluates teaching skills and activities like lab exercises, field trips, and promoting personal experiences incorporated therein.

  14. International Exchange with a Disability: Enhancing Experiences Abroad through Advising and Mentoring (Practice Brief)

    ERIC Educational Resources Information Center

    Holben, Ashley; Özel, Claire

    2015-01-01

    Through interaction with an advisor or peer mentor and through exposure to the experiences of role models, students with disabilities gain an appreciation of the potential challenges and benefits of international exchange and make informed choices about whether, where, and how to go abroad. By adopting strategies for inclusive advising and role…

  15. Poly(methyl vinyl ether-alt-maleic acid)-functionalized porous silicon nanoparticles for enhanced stability and cellular internalization.

    PubMed

    Shahbazi, Mohammad-Ali; Almeida, Patrick V; Mäkilä, Ermei; Correia, Alexandra; Ferreira, Mónica P A; Kaasalainen, Martti; Salonen, Jarno; Hirvonen, Jouni; Santos, Hélder A

    2014-03-01

    Currently, developing a stable nanocarrier with high cellular internalization and low toxicity is a key bottleneck in nanomedicine. Here, we have developed a successful method to covalently conjugate poly(methyl vinyl ether-co-maleic acid) (PMVE-MA) copolymer on the surface of (3-aminopropyl)triethoxysilane-functionalized thermally carbonized porous silicon nanoparticles (APSTCPSi NPs), forming a surface negatively charged nanovehicle with unique properties. This polymer conjugated NPs could modify surface smoothness, charge, and hydrophilicity of the developed NPs, leading to considerable improvement in the colloidal and plasma stabilities via enhanced suspensibility and charge repulsion. Furthermore, despite the surface negative charge of the polymer-conjugated NPs, the cellular internalization was increased in both MDA-MB-231 and MCF-7 breast cancer cells. These results provide a proof-of-concept evidence that such polymer-based PSi nanocomposite can be extensively used as a promising candidate for intracellular drug delivery.

  16. Enhanced excitonic photoconductivity due to built-in internal electric field in TlGaSe{sub 2} layered semiconductor

    SciTech Connect

    Seyidov, MirHasan Yu. Suleymanov, Rauf A.; Şale, Yasin; Balaban, Ertan

    2014-12-07

    The strong enhancement, by several orders of magnitude, of the excitonic peak within the photoconductivity spectrum of TlGaSe{sub 2} semiconductor was observed. The samples were polarized in external dc electric field, which was applied prior to the measurements. Due to the accumulation of charges near the surface, an internal electric field was formed. Electron-hole pairs that were created after the absorption of light are fallen in and then separated by the built-in electric field, which prevents radiative recombination process.

  17. Enhancement of Apoptosis by Titanium Alloy Internal Fixations during Microwave Treatments for Fractures: An Animal Study

    PubMed Central

    Zhang, Lina; Ye, Dongmei; Feng, Xianxuan; Fu, Tengfei; Bai, Yuehong

    2015-01-01

    Objective Microwaves are used in one method of physical therapy and can increase muscle tissue temperature which is useful for improving muscle, tendon and bone injuries. In the study, we sought to determine whether titanium alloy internal fixations influence apoptosis in tissues subjected to microwave treatments at 2,450 MHz and 40 W during the healing of fractures because this issue is not yet fully understood. Methods In this study, titanium alloy internal fixations were used to treat 3.0-mm transverse osteotomies in the middle of New Zealand rabbits’ femurs. After the operation, 30-day microwave treatments were applied to the 3.0 mm transverse osteotomies 3 days after the operation. The changes in the temperatures of the muscle tissues in front of the implants or the 3.0 mm transverse osteotomies were measured during the microwave treatments. To characterize the effects of titanium alloy internal fixations on apoptosis in the muscles after microwave treatment, we performed TUNEL assays, fluorescent real-time (quantitative) PCR, western blotting analyses, reactive oxygen species (ROS) detection and transmission electron microscopy examinations. Results The temperatures were markedly increased in the animals with the titanium alloy implants. Apoptosis in the muscle cells of the implanted group was significantly more extensive than that in the non-implanted control group at different time points. Transmission electron microscopy examinations of the skeletal muscles of the implanted groups revealed muscular mitochondrial swelling, vacuolization. ROS, Bax and Hsp70 were up-regulated, and Bcl-2 was down-regulated in the implanted group. Conclusion Our results suggest that titanium alloy internal fixations caused greater muscular tissue cell apoptosis following 2,450 MHz, 40 W microwave treatments in this rabbit femur fracture models. PMID:26132082

  18. Enhanced Patient-Centred Care: Physiotherapists' Perspectives on the Impact of International Clinical Internships on Canadian Practice

    PubMed Central

    Bourgeois, Anne-Marie; McCurry, Ellen; Condren, Allison; Petropanagos, Peter; Fraser, Michelle; Nixon, Stephanie A.

    2015-01-01

    ABSTRACT Purpose: To explore the perspectives of physiotherapists who participated in an international clinical internship (ICI) in low- or middle-income countries (LMICs) during their physiotherapy (PT) training in a Canadian PT programme regarding the ICI's impact on their PT practice in Canada. Methods: This qualitative descriptive study used in-depth semi-structured interviews. Data were organized using NVivo; inductive and deductive coding were used to analyze data and develop broader themes. Results: The 13 practising Canadian physiotherapists interviewed described three enhanced capacities: (1) critical reflection on culture, values and practice; (2) communication skills; and (3) creativity and resourcefulness. These capacities were perceived to transfer to Canadian practice by enhancing participants' ability to deliver patient-centred care, specifically through an enhanced understanding of patients' values and social determinants of health, regardless of the Canadian setting or patient population. Conclusions: For PT students considering an ICI, the study findings provide insight into the perceived impact of ICIs on Canadian practice. For PT academic programmes, the findings can guide decisions on the extent of investment in ICIs as learning opportunities that will enhance practice in Canada. PMID:27504039

  19. Vectorization of biomacromolecules into cells using extracellular vesicles with enhanced internalization induced by macropinocytosis

    PubMed Central

    Nakase, Ikuhiko; Noguchi, Kosuke; Fujii, Ikuo; Futaki, Shiroh

    2016-01-01

    Extracellular vesicles (EVs, exosomes) are approximately 30- to 200-nm-long vesicles that have received increased attention due to their role in cell-to-cell communication. Although EVs are highly anticipated to be a next-generation intracellular delivery tool because of their pharmaceutical advantages, including non-immunogenicity, their cellular uptake efficacy is low because of the repulsion of EVs and negatively charged cell membranes and size limitations in endocytosis. Here, we demonstrate a methodology for achieving enhanced cellular EV uptake using arginine-rich cell-penetrating peptides (CPPs) to induce active macropinocytosis. The induction of macropinocytosis via a simple modification to the exosomal membrane using stearylated octaarginine, which is a representative CPP, significantly enhanced the cellular EV uptake efficacy. Consequently, effective EV-based intracellular delivery of an artificially encapsulated ribosome-inactivating protein, saporin, in EVs was attained. PMID:27748399

  20. A Decision Support Framework for Feasibility Analysis of International Space Station (ISS) Research Capability Enhancing Options

    NASA Technical Reports Server (NTRS)

    Ortiz, James N.; Scott,Kelly; Smith, Harold

    2004-01-01

    The assembly and operation of the ISS has generated significant challenges that have ultimately impacted resources available to the program's primary mission: research. To address this, program personnel routinely perform trade-off studies on alternative options to enhance research. The approach, content level of analysis and resulting outputs of these studies vary due to many factors, however, complicating the Program Manager's job of selecting the best option. To address this, the program requested a framework be developed to evaluate multiple research-enhancing options in a thorough, disciplined and repeatable manner, and to identify the best option on the basis of cost, benefit and risk. The resulting framework consisted of a systematic methodology and a decision-support toolset. The framework provides quantifiable and repeatable means for ranking research-enhancing options for the complex and multiple-constraint domain of the space research laboratory. This paper describes the development, verification and validation of this framework and provides observations on its operational use.

  1. Enhanced international prognostic index in Japanese patients with diffuse large B-cell lymphoma.

    PubMed

    Nakaya, Aya; Fujita, Shinya; Satake, Atsushi; Nakanishi, Takahisa; Azuma, Yoshiko; Tsubokura, Yukie; Hotta, Masaaki; Yoshimura, Hideaki; Ishii, Kazuyoshi; Ito, Tomoki; Nomura, Shosaku

    2016-01-01

    To evaluate the National Comprehensive Cancer Network (NCCN) International Prognostic Index (IPI), we analyzed 284 patients treated with the combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in our institution in Japan. Their 5-year overall survival (OS) by risk level was 80.7%, 74.8%, 55.4% and 67.5% (P=0.005); and their 5-year progression-free survival (PFS) was 76.8%, 78.6%, 63.7% and 58.3% (P=0.0722). The NCCN-IPI is a simple scale that uses conventional clinical factors, but did not reflect survival in our cohort. The NCCN-IPI may require further evaluation for different regions and ethnicities before adopting it for routine clinical use. PMID:27489766

  2. A new partnership to enhance international competitiveness for coal-related industries

    SciTech Connect

    Schobert, H.H.; Mitchell, G.D.; Finkelman, R.B.

    1999-07-01

    Conducting business in countries with significant indigenous coal supplies and expected economic growth (China, Indonesia, India, Russia, Ukraine, South Africa, Columbia, Brazil, and Venezuela) is extremely difficult, not only from a socio-economic/cultural standpoint, but because little reliable information is available on the properties and quality of raw materials. The question is how to compete and create opportunities in these countries when little or nothing is known about the properties of the indigenous raw materials. To address this concern the Penn State University and the U.S. Geological Survey (USGS) are partnering to develop an integrated database and sample bank of international coal and limestone samples of commercial value to power generation. The purpose of this partnership is to provide a reliable database linked to a convenient sample bank that would aid in resource evaluation and testing with regard to coal utilization including, but not limited to, combustion and combustion engineering, coke making, liquefaction, gasification, coalbed methane recovery, coal preparation, and mining. The Penn State-USGS-Private Sector partnership offers unique potential to provide this valuable service. The Penn State Energy Institute maintains a wide variety of analytical and testing equipment and expertise in coal-related engineering, chemistry and geology and has access to much more throughout the University system. For several decades the Institute has successfully maintained a large domestic coal sample bank. The USGS maintains a state-of-the-art analytical facility and a comprehensive domestic coal quality database. The USGS is actively working in about thirty countries to develop a reliable international coal quality database. Private sector will bring insights into the issues of competitiveness, certain knowledge of the marketplace and financial support.

  3. Enhancing the Environmental Legacy of the International Polar Year 2007- 2008

    NASA Astrophysics Data System (ADS)

    Tin, T.; Roura, R.; Perrault, M.

    2006-12-01

    The International Geophysical Year (IGY) left a legacy of peace and international cooperation in the form of the 1959 Antarctic Treaty. Since the IGY, the 1991 Protocol of Environmental Protection to the Antarctic Treaty was signed and entered into force. The Protocol establishes that the protection of the environment and the wilderness values of Antarctica "shall be fundamental considerations in the planning and conduct of all activities in the Antarctic Treaty area". Fifty years on, the IPY 2007-08 can, in turn, leave behind a positive environmental legacy - where the sharing of facilities and logistics are encouraged, the human footprint in Antarctica is minimized and a future generation of environmentally aware scientists, logisticians and visitors is fostered. Based on an analysis of all Expressions of Interest submitted to the IPY, we found that about three-quarters of IPY's Antarctic projects plan to have fieldwork components. About one-third of these field projects expect to leave physical infrastructure in Antarctica. A number of projects plan to develop large-scale infrastructure, such as stations and observatories, in hitherto pristine areas. Fewer than one percent of Antarctic field projects address the issue of their environmental legacy: four projects indicated that the site will be cleaned up or the equipment will be removed at the end of the project; two projects indicated that their results may be useful for the management of the Antarctic environment, e.g., in the control of invasive species or setting up of marine protected areas. With the goal of increasing the environmental awareness of Antarctic field scientists, our contribution will review current research on the impacts of human activities science, tourism, exploitation of marine resources and global climate change - on the Antarctic environment. A preliminary analysis of the cumulative impacts of IPY activities will be presented. Case studies of scientific projects in Antarctica with a

  4. Technique for internal channelling of hydroentangled nonwoven scaffolds to enhance cell penetration.

    PubMed

    Durham, Elaine R; Ingham, Eileen; Russell, Stephen J

    2013-08-01

    An important requirement in thick, high-porosity scaffolds is to maximise cellular penetration into the interior and avoid necrosis during culture in vitro. Hitherto, reproducible control of the pore structure in nonwoven scaffolds has proved challenging. A new, channelled scaffold manufacturing process is reported based on water jet entanglement of fibres (hydroentangling) around filamentous template to form a coherent scaffold that is subsequently removed. Longitudinally-oriented channels were introduced within the scaffold in controlled proximity using 220 µm diameter cylindrical templates. In this case study, channelled scaffolds composed of poly(l-lactic acid) were manufactured and evaluated in vitro. Environmental scanning electron microscope and µCT (X-ray microtomography) confirmed channel openings in the scaffold cross-section before and after cell culture with human dermal fibroblasts up to 14 weeks. Histology at week 11 indicated that the channels promoted cell penetration and distribution within the scaffold interior. At week 14, cellular matrix deposition was evident in the internal channel walls and the entrances remained unoccluded by cellular matrix suggesting that diffusion conduits for mass transfer of nutrient to the scaffold interior could be maintained.

  5. Technique for internal channelling of hydroentangled nonwoven scaffolds to enhance cell penetration

    PubMed Central

    Durham, Elaine R; Ingham, Eileen; Russell, Stephen J

    2013-01-01

    An important requirement in thick, high-porosity scaffolds is to maximise cellular penetration into the interior and avoid necrosis during culture in vitro. Hitherto, reproducible control of the pore structure in nonwoven scaffolds has proved challenging. A new, channelled scaffold manufacturing process is reported based on water jet entanglement of fibres (hydroentangling) around filamentous template to form a coherent scaffold that is subsequently removed. Longitudinally-oriented channels were introduced within the scaffold in controlled proximity using 220 µm diameter cylindrical templates. In this case study, channelled scaffolds composed of poly(l-lactic acid) were manufactured and evaluated in vitro. Environmental scanning electron microscope and µCT (X-ray microtomography) confirmed channel openings in the scaffold cross-section before and after cell culture with human dermal fibroblasts up to 14 weeks. Histology at week 11 indicated that the channels promoted cell penetration and distribution within the scaffold interior. At week 14, cellular matrix deposition was evident in the internal channel walls and the entrances remained unoccluded by cellular matrix suggesting that diffusion conduits for mass transfer of nutrient to the scaffold interior could be maintained. PMID:22532409

  6. Enhanced light absorption in GaAs solar cells with internal Bragg reflectors

    NASA Astrophysics Data System (ADS)

    Tobin, S. P.; Vernon, S. M.; Sanfacon, M. M.; Mastrovito, A.

    The use of epitaxial multilayer dielectric mirrors (Bragg reflectors) as back-surface reflectors in thin-film GaAs solar cells on GaAs and silicon substrates is investigated. Al0.3Ga0.9As/Al0.85Ga0.15As Bragg reflectors were grown by low-pressure MOCVD on GaAs substrates and shown to exhibit near-ideal optical reflectance and structural perfection. Thin GaAs solar cells grown on Bragg reflectors showed increases in short-circuit current (0.5 to 1.0 mA/sq cm) and efficiency (0.7 percentage points) relative to cells without back reflectors. Efficiencies of 24.7 percent at one sun AM1.5 were measured for GaAs cells only 2 microns thick on Bragg reflectors. In addition to the optical enhancements, Bragg reflectors also appear to improve the defect structure of GaAs-on-Si solar cells. This approach should lead to improved efficiency for GaAs-on-Si solar cells and improved radiation resistance on GaAs cells.

  7. Adaptive cellular structures and devices with internal features for enhanced structural performance

    NASA Astrophysics Data System (ADS)

    Pontecorvo, Michael Eugene

    This dissertation aims to develop a family of cellular and repeatable devices that exhibit a variety of force-displacement behaviors. It is envisioned that these cellular structures might be used either as stand-alone elements, or combined and repeated to create multiple types of structures (i.e. buildings, ship hulls, vehicle subfloors, etc.) with the ability to passively or actively perform multiple functions (harmonic energy dissipation, impact mitigation, modulus change) over a range of loading types, amplitudes, and frequencies. To accomplish this goal, this work combines repeatable structural frameworks, such as that provided by a hexagonal cellular structure, with internal structural elements such as springs, viscous dampers, buckling plates, bi-stable von Mises trusses (VMTs), and pneumatic artificial muscles (PAMs). The repeatable framework serves to position damping and load carrying elements throughout the structure, and the configuration of the internal elements allow each cell to be tuned to exhibit a desired force-displacement response. Therefore, gradient structures or structures with variable load paths can be created for an optimal global response to a range of loads. This dissertation focuses on the development of cellular structures for three functions: combined load-carrying capability with harmonic energy dissipation, impact mitigation, and cell modulus variation. One or more conceptual designs are presented for devices that can perform each of these functions, and both experimental measurements and simulations are used to gain a fundamental understanding of each device. Chapter 2 begins with a presentation of a VMT model that is the basis for many of the elements. The equations of motion for the VMT are derived and the static and dynamic behavior of the VMT are discussed in detail. Next, two metrics for the energy dissipation of the VMT - hysteresis loop area and loss factor - are presented. The responses of the VMT to harmonic displacement

  8. Enhanced beam amplification in a photorefractive Bi{sub 12}TiO{sub 20} crystal by internal reflections

    SciTech Connect

    Khomenko, A.V.; Garcia-Weidner, A.; Tentori, D.

    1996-06-01

    We demonstrate experimentally that internal reflections of a signal and (or) a pump beam allow one to increase beam amplification by two-beam coupling in a long Bi{sub 12}TiO{sub 20} crystal. When fanning is negligible, we achieve an enhancement of the amplification by adjustment of the spatial period of the transformation of the beam{close_quote}s polarization states with periodic reflections of the beams on the crystal boundaries. For the case of strong fanning the fanned beam is redirected by the reflections on the crystal surface, which allows one to use it as a pump beam, thus increasing net amplification gain. {copyright} {ital 1996 Optical Society of America.}

  9. International Family, Adult, and Child Enhancement Services (FACES): a community-based comprehensive services model for refugee children in resettlement.

    PubMed

    Birman, Dina; Beehler, Sarah; Harris, Emily Merrill; Everson, Mary Lynn; Batia, Karen; Liautaud, Joan; Frazier, Stacy; Atkins, Marc; Blanton, Shanika; Buwalda, Johanna; Fogg, Louis; Cappella, Elise

    2008-01-01

    The development of evidence-based mental health interventions for refugees is complicated by the cultural and linguistic diversity of the participants, and the need to balance treatment of past traumatic experiences with ongoing support during the process of acculturation. In an effort to gather "practice-based evidence" from existing mental health services for refugees, a collaborative study of International Family, Adult, and Child Enhancement Services (FACES), a comprehensive, community-based mental health program working with refugee children, was conducted to describe the program participants and service delivery model and to assess whether participants improved over time as a function of services. Results showed that participants improved, but that the improvement was not related to dosage of services. Implications of these findings for refugee mental health services are discussed and suggestions are made for future evaluation research of mental health services with refugees.

  10. International Family, Adult, and Child Enhancement Services (FACES): a community-based comprehensive services model for refugee children in resettlement.

    PubMed

    Birman, Dina; Beehler, Sarah; Harris, Emily Merrill; Everson, Mary Lynn; Batia, Karen; Liautaud, Joan; Frazier, Stacy; Atkins, Marc; Blanton, Shanika; Buwalda, Johanna; Fogg, Louis; Cappella, Elise

    2008-01-01

    The development of evidence-based mental health interventions for refugees is complicated by the cultural and linguistic diversity of the participants, and the need to balance treatment of past traumatic experiences with ongoing support during the process of acculturation. In an effort to gather "practice-based evidence" from existing mental health services for refugees, a collaborative study of International Family, Adult, and Child Enhancement Services (FACES), a comprehensive, community-based mental health program working with refugee children, was conducted to describe the program participants and service delivery model and to assess whether participants improved over time as a function of services. Results showed that participants improved, but that the improvement was not related to dosage of services. Implications of these findings for refugee mental health services are discussed and suggestions are made for future evaluation research of mental health services with refugees. PMID:18444734

  11. SUMMARY OF 2010 DOE EM INTERNATIONAL PROGRAM STUDIES OF WASTE GLASS MELT RATE ENHANCEMENT

    SciTech Connect

    Fox, K.; Marra, J.

    2011-01-19

    A collaborative study has been established under the U.S. Department of Energy (DOE) Office of Environmental Management International Program between the Savannah River National Laboratory (SRNL) and the V. G. Khlopin Radium Institute (KRI) in St. Petersburg, Russia, to investigate potential improvements in melt rate via chemical additions to the glass frit. Researchers at KRI suggested a methodology for selecting frit additives based on empirical coefficients for optimization of glass melting available in the Russian literature. Using these coefficients, KRI identified B{sub 2}O{sub 3}, CuO, and MnO as frit additives that were likely to improve melt rate without having adverse effects on crystallization of the glass or its chemical durability. The results of the melt rate testing in the SMK melter showed that the slurry feed rate (used as a gauge of melt rate) could be significantly increased when MnO or CuO were added to Frit 550 with the SMR-2 sludge. The feed rates increased by about 27% when MnO was added to the frit and by about 26% when CuO was added to the frit, as compared to earlier results for Frit 550 alone. The impact of adding additional B{sub 2}O{sub 3} to the frit was minor when added with CuO. The additional B{sub 2}O{sub 3} showed a more significant, 39% improvement in melt rate when added with MnO. The additional B{sub 2}O{sub 3} also reduced the viscosity of the glasses during pouring. Samples of the glasses from the melt rate testing characterized at SRNL showed that there were no significant impacts on crystallization of the glasses. All of the glasses had very good chemical durability. Chemical composition measurements showed that the frit additives were present in concentrations below the targeted values in some of the glasses. Therefore, it is possible that higher concentrations of these additives may further improve melt rate, although the impacts of higher concentrations of these components on crystallization and durability would need to

  12. An Ultra-High Fluorescence Enhancement and High Throughput Assay for Revealing Expression and Internalization of Chemokine Receptor CXCR4.

    PubMed

    He, Hua; Wang, Xiaojuan; Cheng, Tiantian; Xia, Yongqing; Lao, Jun; Ge, Baosheng; Ren, Hao; Khan, Naseer Ullah; Huang, Fang

    2016-04-18

    Revealing chemokine receptor CXCR4 expression, distribution, and internalization levels in different cancers helps to evaluate cancer progression or prognosis and to set personalized treatment strategy. We here describe a sensitive and high-throughput immunoassay for determining CXCR4 expression and distribution in cancer cells. The assay is accessible to a wide range of users in an ordinary lab only by dip-coating poly(styrene-co-N-isopropylacrylamide) spheres on the glass substrate. The self- assembled spheres form three-dimensional photonic colloidal crystals which enhance the fluorescence of CF647 and Alexa Fluor 647 by a factor of up to 1000. CXCR4 in cells is detected by using the sandwich immunoassay, where the primary antibody recognizes CXCR4 and the secondary antibody is labeled with CF647. With the newly established assay, we quantified the total expression of CXCR4, its distribution on the cell membrane and cytoplasm, and revealed their internalization level upon SDF-1α activation in various cancer cells, even for those with extremely low expression level. PMID:26879206

  13. Adaptive cellular structures and devices with internal features for enhanced structural performance

    NASA Astrophysics Data System (ADS)

    Pontecorvo, Michael Eugene

    This dissertation aims to develop a family of cellular and repeatable devices that exhibit a variety of force-displacement behaviors. It is envisioned that these cellular structures might be used either as stand-alone elements, or combined and repeated to create multiple types of structures (i.e. buildings, ship hulls, vehicle subfloors, etc.) with the ability to passively or actively perform multiple functions (harmonic energy dissipation, impact mitigation, modulus change) over a range of loading types, amplitudes, and frequencies. To accomplish this goal, this work combines repeatable structural frameworks, such as that provided by a hexagonal cellular structure, with internal structural elements such as springs, viscous dampers, buckling plates, bi-stable von Mises trusses (VMTs), and pneumatic artificial muscles (PAMs). The repeatable framework serves to position damping and load carrying elements throughout the structure, and the configuration of the internal elements allow each cell to be tuned to exhibit a desired force-displacement response. Therefore, gradient structures or structures with variable load paths can be created for an optimal global response to a range of loads. This dissertation focuses on the development of cellular structures for three functions: combined load-carrying capability with harmonic energy dissipation, impact mitigation, and cell modulus variation. One or more conceptual designs are presented for devices that can perform each of these functions, and both experimental measurements and simulations are used to gain a fundamental understanding of each device. Chapter 2 begins with a presentation of a VMT model that is the basis for many of the elements. The equations of motion for the VMT are derived and the static and dynamic behavior of the VMT are discussed in detail. Next, two metrics for the energy dissipation of the VMT - hysteresis loop area and loss factor - are presented. The responses of the VMT to harmonic displacement

  14. Shared visions: Partnership of Rockwell International and NASA Cost Effectiveness Enhancements (CEE) for the space shuttle system integration program

    NASA Technical Reports Server (NTRS)

    Bejmuk, Bohdan I.; Williams, Larry

    1992-01-01

    As a result of limited resources and tight fiscal constraints over the past several years, the defense and aerospace industries have experienced a downturn in business activity. The impact of fewer contracts being awarded has placed a greater emphasis for effectiveness and efficiency on industry contractors. It is clear that a reallocation of resources is required for America to continue to lead the world in space and technology. The key to technological and economic survival is the transforming of existing programs, such as the Space Shuttle Program, into more cost efficient programs so as to divert the savings to other NASA programs. The partnership between Rockwell International and NASA and their joint improvement efforts that resulted in significant streamlining and cost reduction measures to Rockwell International Space System Division's work on the Space Shuttle System Integration Contract is described. This work was a result of an established Cost Effectiveness Enhancement (CEE) Team formed initially in Fiscal Year 1991, and more recently expanded to a larger scale CEE Initiative in 1992. By working closely with the customer in agreeing to contract content, obtaining management endorsement and commitment, and involving the employees in total quality management (TQM) and continuous improvement 'teams,' the initial annual cost reduction target was exceeded significantly. The CEE Initiative helped reduce the cost of the Shuttle Systems Integration contract while establishing a stronger program based upon customer needs, teamwork, quality enhancements, and cost effectiveness. This was accomplished by systematically analyzing, challenging, and changing the established processes, practices, and systems. This examination, in nature, was work intensive due to the depth and breadth of the activity. The CEE Initiative has provided opportunities to make a difference in the way Rockwell and NASA work together - to update the methods and processes of the organizations

  15. Shared visions: Partnership of Rockwell International and NASA Cost Effectiveness Enhancements (CEE) for the space shuttle system integration program

    NASA Astrophysics Data System (ADS)

    Bejmuk, Bohdan I.; Williams, Larry

    As a result of limited resources and tight fiscal constraints over the past several years, the defense and aerospace industries have experienced a downturn in business activity. The impact of fewer contracts being awarded has placed a greater emphasis for effectiveness and efficiency on industry contractors. It is clear that a reallocation of resources is required for America to continue to lead the world in space and technology. The key to technological and economic survival is the transforming of existing programs, such as the Space Shuttle Program, into more cost efficient programs so as to divert the savings to other NASA programs. The partnership between Rockwell International and NASA and their joint improvement efforts that resulted in significant streamlining and cost reduction measures to Rockwell International Space System Division's work on the Space Shuttle System Integration Contract is described. This work was a result of an established Cost Effectiveness Enhancement (CEE) Team formed initially in Fiscal Year 1991, and more recently expanded to a larger scale CEE Initiative in 1992. By working closely with the customer in agreeing to contract content, obtaining management endorsement and commitment, and involving the employees in total quality management (TQM) and continuous improvement 'teams,' the initial annual cost reduction target was exceeded significantly. The CEE Initiative helped reduce the cost of the Shuttle Systems Integration contract while establishing a stronger program based upon customer needs, teamwork, quality enhancements, and cost effectiveness. This was accomplished by systematically analyzing, challenging, and changing the established processes, practices, and systems. This examination, in nature, was work intensive due to the depth and breadth of the activity. The CEE Initiative has provided opportunities to make a difference in the way Rockwell and NASA work together - to update the methods and processes of the organizations

  16. Photochemical internalization (PCI) enhanced nonviral transfection of tumor suppressor and pro-drug activating genes; a potential treatment modality for gliomas

    NASA Astrophysics Data System (ADS)

    Wang, Frederick; Zamora, Genesis; Sun, Chung-Ho; Trinidad, Anthony; Berg, Kristian; Madsen, Steen; Kwon, Young Jik; Hirschberg, Henry

    2014-03-01

    The overall objective of the research is to investigate the utility of photochemical internalization for the enhanced nonviral transfection of genes into cells. We have examined, in detail, the evaluation of photochemical internalization (PCI) as a method for the non-viral introduction of the tumor suppressor gene PTEN and the PCI mediated transfection of the cytosine deaminase (CD) pro drug activating gene into glioma cell monolayers and multi-cell tumor spheroids. Expression of the CD gene within the target cell produces an enzyme that converts the nontoxic prodrug, 5-fluorocytosine (5-FC), to the toxic metabolite, 5-fluorouracil (5-FU).

  17. Internal heavy atom effect of Au(III) and Pt(IV) on hypocrellin A for enhanced in vitro photodynamic therapy of cancer.

    PubMed

    Zhou, Lin; Ge, Xuefeng; Liu, Jihua; Zhou, Jiahong; Wei, Shaohua; Li, Fuyou; Shen, Jian

    2013-10-01

    Hypocrellin A (HA), an a natural perylene quinine photosensitizers (PSs), can chelate with heavy metal ions, including Au(III) and Pt(IV), to form a 1:2 complex, which exhibits enhanced (1)O2 generation quantum yield through the increased intersystem crossing efficiency mediated by internal heavy atom effect. Besides, the chelate process greatly improved the water solubility of HA. Comparative studies with HA and complexes have demonstrated that the heavy-atom effect on HA molecules enhances the efficiency of in vitro photodynamic (PDT) efficacy.

  18. Enhanced Rates of Hydrogen Absorption Resulting from Oxidation of Pd and Internal Oxidation of Pd-Al Alloys

    SciTech Connect

    Shanahan, K.L.

    1999-08-20

    The goal of this research was the determination of the relative rates before and after internal oxidation of Pd--Al alloys and oxidation (Pd) and this is independent of whether heat transfer is the rate-limiting step for the internally oxidized Pd--Al alloys rather than a more fundamental step.

  19. Proposals to clarify and enhance the naming of fungi under the International Code of Nomenclature for algae, fungi, and plants.

    PubMed

    Hawksworth, David L

    2015-06-01

    Twenty-three proposals to modify the International Code of Nomenclature for algae, fungi, and plants adopted in 2011 with respect to the provisions for fungi are made, in accordance with the wishes of mycologists expressed at the 10(th) International Mycological Congress in Bangkok in 2014, and with the support of the International Commission on the Taxonomy of Fungi (ICTF), the votes of which are presented here. The proposals relate to: conditions for epitypification, registration of later typifications, protected lists of names, removal of exemptions for lichen-forming fungi, provision of a diagnosis when describing a new taxon, citation of sanctioned names, avoiding homonyms in other kingdoms, ending preference for sexually typified names, and treatment of conspecific names with the same epithet. These proposals are also being published in Taxon, will be considered by the Nomenclature Committee for Fungi and General Committee on Nomenclature, and voted on at the 19(th) International Botanical Congress in Shenzhen, China, in 2017. PMID:26203423

  20. Enhancing Research Ethics Review Systems in Egypt: The Focus of an International Training Program Informed by an Ecological Developmental Approach to Enhancing Research Ethics Capacity.

    PubMed

    Edwards, Hillary Anne; Hifnawy, Tamer; Silverman, Henry

    2015-12-01

    Recently, training programs in research ethics have been established to enhance individual and institutional capacity in research ethics in the developing world. However, commentators have expressed concern that the efforts of these training programs have placed 'too great an emphasis on guidelines and research ethics review', which will have limited effect on ensuring ethical conduct in research. What is needed instead is a culture of ethical conduct supported by national and institutional commitment to ethical practices that are reinforced by upstream enabling conditions (strong civil society, public accountability, and trust in basic transactional processes), which are in turn influenced by developmental conditions (basic freedoms of political freedoms, economic facilities, social opportunities, transparency guarantees, and protective security). Examining this more inclusive understanding of the determinants of ethical conduct enhances at once both an appreciation of the limitations of current efforts of training programs in research ethics and an understanding of what additional training elements are needed to enable trainees to facilitate national and institutional policy changes that enhance research practices. We apply this developmental model to a training program focused in Egypt to describe examples of such additional training activities.

  1. Enhancing the International Business Curriculum through Partnership with the United States Department of Commerce: The "E" Award Internship Program

    ERIC Educational Resources Information Center

    Mello, Jeffrey A.

    2006-01-01

    Management education has been subjected to scrutiny and criticism over its lack of relevance to the "real world" of management practice. In response, many institutions have developed and, in some cases, require students to complete an internship as part of their degree requirements. International business is a field of study where internships can…

  2. Visual Literacy--Enhancing Human Potential. Readings from the 15th Annual Conference of the International Visual Literacy Association.

    ERIC Educational Resources Information Center

    Walker, Alice D., Ed.; And Others

    This document includes 46 papers presented at the International Visual Literacy Association Conference on topics ranging from prehistoric cave paintings to technology of the future. Major sections are devoted to research and theory, education, computer technology, and phototherapy. Emphasis is on increased understanding of opportunities available…

  3. Integrated Logistics Support Analysis of the International Space Station Alpha: An Overview of the Maintenance Time Dependent Parameter Prediction Methods Enhancement

    NASA Technical Reports Server (NTRS)

    Sepehry-Fard, F.; Coulthard, Maurice H.

    1995-01-01

    The objective of this publication is to introduce the enhancement methods for the overall reliability and maintainability methods of assessment on the International Space Station. It is essential that the process to predict the values of the maintenance time dependent variable parameters such as mean time between failure (MTBF) over time do not in themselves generate uncontrolled deviation in the results of the ILS analysis such as life cycle costs, spares calculation, etc. Furthermore, the very acute problems of micrometeorite, Cosmic rays, flares, atomic oxygen, ionization effects, orbital plumes and all the other factors that differentiate maintainable space operations from non-maintainable space operations and/or ground operations must be accounted for. Therefore, these parameters need be subjected to a special and complex process. Since reliability and maintainability strongly depend on the operating conditions that are encountered during the entire life of the International Space Station, it is important that such conditions are accurately identified at the beginning of the logistics support requirements process. Environmental conditions which exert a strong influence on International Space Station will be discussed in this report. Concurrent (combined) space environments may be more detrimental to the reliability and maintainability of the International Space Station than the effects of a single environment. In characterizing the logistics support requirements process, the developed design/test criteria must consider both the single and/or combined environments in anticipation of providing hardware capability to withstand the hazards of the International Space Station profile. The effects of the combined environments (typical) in a matrix relationship on the International Space Station will be shown. The combinations of the environments where the total effect is more damaging than the cumulative effects of the environments acting singly, may include a

  4. Molecular Inclusion Complexes of β-Cyclodextrin Derivatives Enhance Aqueous Solubility and Cellular Internalization of Paclitaxel: Preformulation and In vitro Assessments

    PubMed Central

    Shah, Milin; Shah, Vatsal; Ghosh, Anasuya; Zhang, Zheng; Minko, Tamara

    2015-01-01

    Drugs with low aqueous solubility and permeability possess substantial challenges in designing effective and safe formulations. Synergistic solubility and permeability enhancement in a simple formulation can increase bioavailability and efficacy of such drugs. To overcome limitations of the clinical formulation of Taxol®, Paclitaxel (PTX) was reformulated with various β-cyclodextrin (CD) derivatives suitable for parenteral administration. Results indicated that β-CDs can efficiently form complexes with PTX at lower molar ratios, enhance aqueous solubility up to 500 times and improved cellular internalization of PTX. All β-CD derivatives were found to be safe as excipient since none showed detectable signs of cyto-genotoxicity. As a result, the CD-PTX complexes significantly increased the cytotoxicity of the drug. The study concluded that CD-PTX formulations could substitute the current intravenous infusion of PTX obviating the use of non-inert excipient Cremophor EL. PMID:25950011

  5. Internalization of the Extracellular Full-Length Tau Inside Neuro2A and Cortical Cells Is Enhanced by Phosphorylation.

    PubMed

    Wauters, Mathilde; Wattiez, Ruddy; Ris, Laurence

    2016-08-19

    Tau protein is mainly intracellular. However, several studies have demonstrated that full-length Tau can be released into the interstitial fluid of the brain. The physiological or pathological function of this extracellular Tau remains unknown. Moreover, as evidence suggests, extracellular Tau aggregates can be internalized by neurons, seeding Tau aggregation. However, much less is known about small species of Tau. In this study, we hypothesized that the status of phosphorylation could alter the internalization of recombinant Tau in Neuro2A and cortical cells. Our preliminary results revealed that the highly phosphorylated form of Tau entered the cells ten times more easily than a low phosphorylated one. This suggests that hyperphosphorylated Tau protein could spread between neurons in pathological conditions such as Alzheimer's disease.

  6. Internalization of the Extracellular Full-Length Tau Inside Neuro2A and Cortical Cells Is Enhanced by Phosphorylation

    PubMed Central

    Wauters, Mathilde; Wattiez, Ruddy; Ris, Laurence

    2016-01-01

    Tau protein is mainly intracellular. However, several studies have demonstrated that full-length Tau can be released into the interstitial fluid of the brain. The physiological or pathological function of this extracellular Tau remains unknown. Moreover, as evidence suggests, extracellular Tau aggregates can be internalized by neurons, seeding Tau aggregation. However, much less is known about small species of Tau. In this study, we hypothesized that the status of phosphorylation could alter the internalization of recombinant Tau in Neuro2A and cortical cells. Our preliminary results revealed that the highly phosphorylated form of Tau entered the cells ten times more easily than a low phosphorylated one. This suggests that hyperphosphorylated Tau protein could spread between neurons in pathological conditions such as Alzheimer’s disease. PMID:27548242

  7. A tool for enhancing strategic health planning: a modeled use of the International Classification of Functioning, Disability and Health.

    PubMed

    Sinclair, Lisa Bundara; Fox, Michael H; Betts, Donald R

    2013-01-01

    This article describes use of the International Classification of Functioning, Disability and Health (ICF) as a tool for strategic planning. The ICF is the international classification system for factors that influence health, including Body Structures, Body Functions, Activities and Participation and Environmental Factors. An overview of strategic planning and the ICF are provided. Selected ICF concepts and nomenclature are used to demonstrate its utility in helping develop a classic planning framework, objectives, measures and actions. Some issues and resolutions for applying the ICF are described. Applying the ICF for strategic health planning is an innovative approach that fosters the inclusion of social ecological health determinants and broad populations. If employed from the onset of planning, the ICF can help public health organizations systematically conceptualize, organize and communicate a strategic health plan.

  8. Internalization of the Extracellular Full-Length Tau Inside Neuro2A and Cortical Cells Is Enhanced by Phosphorylation.

    PubMed

    Wauters, Mathilde; Wattiez, Ruddy; Ris, Laurence

    2016-01-01

    Tau protein is mainly intracellular. However, several studies have demonstrated that full-length Tau can be released into the interstitial fluid of the brain. The physiological or pathological function of this extracellular Tau remains unknown. Moreover, as evidence suggests, extracellular Tau aggregates can be internalized by neurons, seeding Tau aggregation. However, much less is known about small species of Tau. In this study, we hypothesized that the status of phosphorylation could alter the internalization of recombinant Tau in Neuro2A and cortical cells. Our preliminary results revealed that the highly phosphorylated form of Tau entered the cells ten times more easily than a low phosphorylated one. This suggests that hyperphosphorylated Tau protein could spread between neurons in pathological conditions such as Alzheimer's disease. PMID:27548242

  9. Enhanced internal quantum efficiency and light extraction efficiency from textured GaN/AlGaN quantum wells grown by molecular beam epitaxy

    SciTech Connect

    Cabalu, J.S.; Thomidis, C.; Moustakas, T.D.; Riyopoulos, S.; Zhou Lin; Smith, David J.

    2006-03-15

    GaN/Al{sub 0.2}Ga{sub 0.8}N multiple quantum wells (MQWs) were grown by molecular beam epitaxy on randomly textured and atomically smooth (0001) GaN templates. Smooth and textured GaN templates were deposited on (0001) sapphire substrates by varying the III/V ratio and the substrate temperature during growth by the hydride vapor-phase epitaxy method. We find that the MQWs replicate the texture of the GaN template, which was found to have a Gaussian distribution. The peak photoluminescence intensity from the textured MQWs is always higher than from the smooth MQWs and for GaN (7 nm)/Al{sub 0.2}Ga{sub 0.8}N (8 nm) MQWs, it is 700 times higher than that from similarly produced MQWs on smooth GaN templates. This result is attributed partly to the enhancement in light extraction efficiency and partly to the enhancement in internal quantum efficiency. The origin of the increase in internal quantum efficiency is partly due to the reduction of the quantum-confined Stark effect, since the polarization vector intersects the quantum well (QW) planes at angles smaller than 90 deg. , and partly due to the charge redistribution in the QWs caused by the polarization component parallel to the planes of the QWs.

  10. Enhancing the Quantitative Representation of Socioeconomic Conditions in the Shared Socio-economic Pathways (SSPs) using the International Futures Model

    NASA Astrophysics Data System (ADS)

    Rothman, D. S.; Siraj, A.; Hughes, B.

    2013-12-01

    The international research community is currently in the process of developing new scenarios for climate change research. One component of these scenarios are the Shared Socio-economic Pathways (SSPs), which describe a set of possible future socioeconomic conditions. These are presented in narrative storylines with associated quantitative drivers. The core quantitative drivers include total population, average GDP per capita, educational attainment, and urbanization at the global, regional, and national levels. At the same time there have been calls, particularly by the IAV community, for the SSPs to include additional quantitative information on other key social factors, such as income inequality, governance, health, and access to key infrastructures, which are discussed in the narratives. The International Futures system (IFs), based at the Pardee Center at the University of Denver, is able to provide forecasts of many of these indicators. IFs cannot use the SSP drivers as exogenous inputs, but we are able to create development pathways that closely reproduce the core quantitative drivers defined by the different SSPs, as well as incorporating assumptions on other key driving factors described in the qualitative narratives. In this paper, we present forecasts for additional quantitative indicators based upon the implementation of the SSP development pathways in IFs. These results will be of value to many researchers.

  11. An XML Model of an Enhanced Data Dictionary to Facilitate the Exchange of Clinical Research Data in International Studies

    PubMed Central

    Duda, Stephany N.; Cushman, Clint; Masys, Daniel R.

    2013-01-01

    The clinical research data sets exchanged in international epidemiology research often lack the elements needed to assess their suitability for use in multi-region meta-analyses. While the missing information is generally known to local investigators, it is not contained in the files exchanged between sites. Instead, such content must be solicited by the study coordinating center though a series of lengthy phone and electronic communications: an informal process whose reproducibility and accuracy decays over time. This report describes a set of supplemental information needed to assess whether clinical research data from diverse research sites are truly comparable, and what metadata (“data about the data”) should be preserved when a data set is archived for future use. We propose a structured Extensible Markup Language (XML) model that captures this information. The authors hope this model will be a first step towards preserving the metadata associated with clinical research data sets, thereby improving the quality of international data exchange, data archiving, and merged-data research using data collected in many different countries, languages and care settings. PMID:17911757

  12. A comparative study of ultrasonic pretreatment and an internal recycle for the enhancement of mesophilic anaerobic digestion.

    PubMed

    Muller, Christopher D; Abu-Orf, Mohammad; Blumenschein, Charles D; Novak, John T

    2009-12-01

    The objective of this study was to investigate the use of ultrasonic energy in an internal recycle and pretreatment mode of operation relative to a conventional mode of mesophilic anaerobic digestion. The primary focus was to determine if using ultrasonics in a pretreatment mode and in an internal recycle line produced changes in performance relative to each other and the control. Using a relatively low-energy sonication system, the data showed that the addition of ultrasonic energy, in either a recycle line or as a pretreatment technology, improved anaerobic digestion efficiency for waste-activated sludge. There was a 13 to 21% increase in biogas yield and an increase in total and volatile solids destruction of 3 to 10.3 additional percentage points, depending on the ultrasonic dose and location. Dewatering of the biosolids following ultrasonic treatment was poorer, as measured by an increase in the optimum polymer conditioning dose. The addition of ultrasonics to the digestion systems generated a more stable biosolids product, with a 2 to 58% reduction in organo-sulfur gas production from dewatered biosolids cakes.

  13. Preferred recycling pathway by internalized PGE2 EP4 receptor following agonist stimulation in cultured dorsal root ganglion neurons contributes to enhanced EP4 receptor sensitivity.

    PubMed

    St-Jacques, Bruno; Ma, Weiya

    2016-06-21

    Prostaglandin E2 (PGE2), a well-known pain mediator abundantly produced in injured tissues, sensitizes nociceptive dorsal root ganglion (DRG) neurons (nociceptors) through its four EP receptors (EP1-4). Our prior study showed that PGE2 or EP4 agonist stimulates EP4 externalization and this event was not only suppressed by the inhibitor of anterograde export, but also by the recycling inhibitor (St-Jacques and Ma, 2013). These data suggest that EP4 recycling also contributes to agonist-enhanced EP4 surface abundance. In the current study, we tested this hypothesis using antibody-feeding-based internalization assay, recycling assay and FITC-PGE2 binding assay. We observed that selective EP4 agonist 1-hydroxy-PGE1 (1-OH-PGE1) or CAY10850 time- and concentration-dependently increased EP4 internalization in cultured DRG neuron. Internalized EP4 was predominantly localized in the early endosomes and recycling endosomes, but rarely in the late endosomes and lysosomes. These observations were confirmed by FITC-PGE2 binding assay. We further revealed that 1-OH-PGE1 or CAY10850 time- and concentration-dependently increased EP4 recycling. Double exposures to 1-OH-PGE1 induced a greater increase in calcitonin gene-related peptide (CGRP) release than a single exposure or vehicle exposure, an event blocked by pre-treatment with the recycling inhibitor monensin. Our data suggest that EP4 recycling contributes to agonist-induced cell surface abundance and consequently enhanced receptor sensitivity. Facilitating EP4 externalization and recycling is a novel mechanism underlying PGE2-induced nociceptor sensitization.

  14. Timing matters: negative emotion elicited 5 min but not 30 min or 45 min after learning enhances consolidation of internal-monitoring source memory.

    PubMed

    Wang, Bo; Bukuan, Sun

    2015-05-01

    Two experiments examined the time-dependent effects of negative emotion on consolidation of item and internal-monitoring source memory. In Experiment 1, participants (n=121) learned a list of words. They were asked to read aloud half of the words and to think about the remaining half. They were instructed to memorize each word and its associative cognitive operation ("reading" versus "thinking"). Immediately following learning they conducted free recall and then watched a 3-min either neutral or negative video clip when 5 min, 30 min or 45 min had elapsed after learning. Twenty-four hours later they returned to take surprise tests for item and source memory. Experiment 2 was similar to Experiment 1 except that participants, without conducting an immediate test of free recall, took tests of source memory for all encoded words both immediately and 24 h after learning. Experiment 1 showed that negative emotion enhanced consolidation of item memory (as measured by retention ratio of free recall) regardless of delay of emotion elicitation and that negative emotion enhanced consolidation of source memory when it was elicited at a 5 min delay but reduced consolidation of source memory when it was elicited at a 30 min delay; when elicited at a 45 min delay, negative emotion had little effect. Furthermore, Experiment 2 replicated the enhancement effect on source memory in the 5 min delay even when participants were tested on all the encoded words. The current study partially replicated prior studies on item memory and extends the literature by providing evidence for a time-dependent effect of negative emotion on consolidation of source memory based on internal monitoring.

  15. Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: role of ATP-sensitive potassium channels.

    PubMed

    Dal-Secco, Daniela; Cunha, Thiago M; Freitas, Andressa; Alves-Filho, José Carlos; Souto, Fabrício O; Fukada, Sandra Y; Grespan, Renata; Alencar, Nylane M N; Neto, Alberto F; Rossi, Marcos A; Ferreira, Sérgio H; Hothersall, John S; Cunha, Fernando Q

    2008-09-15

    In this study, we have addressed the role of H(2)S in modulating neutrophil migration in either innate (LPS-challenged naive mice) or adaptive (methylated BSA (mBSA)-challenged immunized mice) immune responses. Treatment of mice with H(2)S synthesis inhibitors, dl-propargylglycine (PAG) or beta-cyanoalanine, reduced neutrophil migration induced by LPS or methylated BSA (mBSA) into the peritoneal cavity and by mBSA into the femur/tibial joint of immunized mice. This effect was associated with decreased leukocyte rolling, adhesion, and P-selectin and ICAM-1 expression on endothelium. Predictably, treatment of animals with the H(2)S donors, NaHS or Lawesson's reagent, enhanced these parameters. Moreover, the NaHS enhancement of neutrophil migration was not observed in ICAM-1-deficient mice. Neither PAG nor NaHS treatment changed LPS-induced CD18 expression on neutrophils, nor did the LPS- and mBSA-induced release of neutrophil chemoattractant mediators TNF-alpha, keratinocyte-derived chemokine, and LTB(4). Furthermore, in vitro MIP-2-induced neutrophil chemotaxis was inhibited by PAG and enhanced by NaHS treatments. Accordingly, MIP-2-induced CXCR2 internalization was enhanced by PAG and inhibited by NaHS treatments. Moreover, NaHS prevented MIP-2-induced CXCR2 desensitization. The PAG and NaHS effects correlated, respectively, with the enhancement and inhibition of MIP-2-induced G protein-coupled receptor kinase 2 expression. The effects of NaHS on neutrophil migration both in vivo and in vitro, together with CXCR2 internalization and G protein-coupled receptor kinase 2 expression were prevented by the ATP-sensitive potassium (K(ATP)(+)) channel blocker, glybenclamide. Conversely, diazoxide, a K(ATP)(+) channel opener, increased neutrophil migration in vivo. Together, our data suggest that during the inflammatory response, H(2)S augments neutrophil adhesion and locomotion, by a mechanism dependent on K(ATP)(+) channels. PMID:18768887

  16. Enhancement of International Dermatologists’ Pigmented Skin Lesion Biopsy Decisions Following Dermoscopy with Subsequent Integration of Multispectral Digital Skin Lesion Analysis

    PubMed Central

    Farberg, Aaron S.; Tucker, Natalie; White, Richard; Rigel, Darrell S.

    2016-01-01

    Background: Early detection and subsequent management of melanoma are critical for patient survival. New technologies have been developed to augment clinician analysis of suspicious pigmented skin lesions. Objective: To determine how information provided by a multispectral digital skin lesion analysis device affects the biopsy decisions of international dermatologists following clinical and dermoscopic pigmented skin lesion evaluation. Methods: Participants at a dermoscopy conference in Vienna, Austria, were shown 12 clinical and dermoscopic images of pigmented skin lesions (2 melanomas in situ, 3 invasive melanomas, and 7 low-grade dysplastic nevi) previously analyzed by multispectral digital skin lesion analysis. Participants were asked if they would biopsy the lesion based on clinical images, again after observing high-resolution dermoscopy images, and again when subsequently shown multispectral digital skin lesion analysis information. Results: Data were analyzed from a total of 70 international dermatologists. Overall, sensitivity was 58 percent after clinical evaluation (C) and 59 percent post-dermoscopy (D), but 74 percent after multispectral digital skin lesion analysis. Participant specificity was 56 percent (C) decreasing to 51 percent (D), but increasing to 61 percent with multispectral digital skin lesion analysis. Diagnostic accuracy was 57 percent (C) decreasing to 54 percent (D), but increasing to 67 percent for dermatologists after integrating the multispectral digital skin lesion analysis data into the biopsy decision. The overall number of lesions biopsied increased from 50 percent (C) to 53 percent (D), rising to 54 percent after multispectral digital skin lesion analysis. Conclusion: Decisions to biopsy melanocytic lesions were more sensitive and specific when multispectral digital skin lesion analysis information was provided with no significant increase in the number of biopsies recommended. Providing multispectral digital skin lesion analysis

  17. Enhancement of International Dermatologists’ Pigmented Skin Lesion Biopsy Decisions Following Dermoscopy with Subsequent Integration of Multispectral Digital Skin Lesion Analysis

    PubMed Central

    Farberg, Aaron S.; Tucker, Natalie; White, Richard; Rigel, Darrell S.

    2016-01-01

    Background: Early detection and subsequent management of melanoma are critical for patient survival. New technologies have been developed to augment clinician analysis of suspicious pigmented skin lesions. Objective: To determine how information provided by a multispectral digital skin lesion analysis device affects the biopsy decisions of international dermatologists following clinical and dermoscopic pigmented skin lesion evaluation. Methods: Participants at a dermoscopy conference in Vienna, Austria, were shown 12 clinical and dermoscopic images of pigmented skin lesions (2 melanomas in situ, 3 invasive melanomas, and 7 low-grade dysplastic nevi) previously analyzed by multispectral digital skin lesion analysis. Participants were asked if they would biopsy the lesion based on clinical images, again after observing high-resolution dermoscopy images, and again when subsequently shown multispectral digital skin lesion analysis information. Results: Data were analyzed from a total of 70 international dermatologists. Overall, sensitivity was 58 percent after clinical evaluation (C) and 59 percent post-dermoscopy (D), but 74 percent after multispectral digital skin lesion analysis. Participant specificity was 56 percent (C) decreasing to 51 percent (D), but increasing to 61 percent with multispectral digital skin lesion analysis. Diagnostic accuracy was 57 percent (C) decreasing to 54 percent (D), but increasing to 67 percent for dermatologists after integrating the multispectral digital skin lesion analysis data into the biopsy decision. The overall number of lesions biopsied increased from 50 percent (C) to 53 percent (D), rising to 54 percent after multispectral digital skin lesion analysis. Conclusion: Decisions to biopsy melanocytic lesions were more sensitive and specific when multispectral digital skin lesion analysis information was provided with no significant increase in the number of biopsies recommended. Providing multispectral digital skin lesion analysis

  18. Enhancing our Understanding of the Arctic Atmospheric Hydrological Cycle using Observations from an International Arctic Water Vapor Isotope Network

    NASA Astrophysics Data System (ADS)

    Masson-Delmotte, V.; Steen-Larsen, H. C.; Werner, M.

    2014-12-01

    Due to the role of water vapor and clouds in positive feedback mechanisms, water vapor is a key player in the future of Arctic climate. Ecosystems and human societies are vulnerable to climate change through even minor changes in precipitation patterns, including the occurrence of extreme events. It is therefore essential to monitor, understand and model correctly the mechanisms of transport of moisture, at the regional scale. Water isotopes - the relative abundance of heavy and light water in the atmosphere - hold the key to understanding the physical processes influencing future Arctic climate. Water isotope observations in the atmosphere are a modern analog to the Rosetta Stone for understanding the processes involved in evaporation, moisture transport, cloud formation and to track moisture origin. Indeed, technological progress now allows continuous, in situ or remote sensing monitoring of water isotopic composition. In parallel, a growing number of atmospheric circulation models are equipped with the explicit modeling of water stable isotopes, allowing evaluation at the process scale. We present here data obtained through national or bi-national initiatives from stations onboard an icebreaker and land based stations in Greenland, Iceland, Svalbard, and Siberia - together forming an emerging international Arctic water vapor isotope network. Using water tagging and back trajectories we show water vapor of Arctic origin to have a high d-excess fingerprint. This show the potential of using water vapor isotopes as tracer for changes in the Arctic hydrological cycle. Using the network of monitoring stations we quantify using the isotopes advection of air masses and the key processes affecting the water vapor en-route between stations. We have successfully used the obtained atmospheric water vapor isotope observations to benchmark isotope-enabled general circulation models. This comparison allows us to address key processes of the atmospheric hydrological cycle for

  19. Enhancing interprofessional education and practice: Development and implementation of a new graduate-level course using the international classification of functioning, disability, and health.

    PubMed

    Nguyen, Tram; Fayed, Nora; Gorter, Jan Willem; MacDermid, Joy

    2016-05-01

    Since the introduction of the World Health Organization's International Classification of Functioning, Disability and Health (ICF), there is increasing awareness among health professionals to consider a biopsychosocial approach to patients' health and functioning. Although diffusion of the ICF as a concept is widely recognized, application of the ICF within health education and practice requires attention, training, and support. This article describes the development and implementation of a new graduate-level course using the ICF to assist health professionals and graduate trainees in rehabilitation. The innovation behind this course is its focus on application of the ICF in research and practice through a combination of peer support and instructor mentorship. The value of the ICF for interprofessional education, research, and practice includes promotion of a broad perspective to health, application of theory in practice, and enhanced communication and collaboration in healthcare. PMID:27028165

  20. Plasma treatment induces internal surface modifications of electrospun poly(L-lactic) acid scaffold to enhance protein coating

    NASA Astrophysics Data System (ADS)

    Jin Seo, Hyok; Hee Lee, Mi; Kwon, Byeong-Ju; Kim, Hye-Lee; Jin Lee, Seung; Kim, Bong-Jin; Wang, Kang-Kyun; Kim, Yong-Rok; Park, Jong-Chul

    2013-08-01

    Advanced biomaterials should also be bioactive with regard to desirable cellular responses, such as selective protein adsorption and cell attachment, proliferation, and differentiation. To enhance cell-material interactions, surface modifications have commonly been performed. Among the various surface modification approaches, atmospheric pressure glow discharge plasma has been used to change a hydrophobic polymer surface to a hydrophilic surface. Poly(L-lactic acid) (PLLA)-derived scaffolds lack cell recognition signals and the hydrophobic nature of PLLA hinders cell seeding. To make PLLA surfaces more conducive to cell attachment and spreading, surface modifications may be used to create cell-biomaterial interfaces that elicit controlled cell adhesion and maintain differentiated phenotypes. In this study, (He) gaseous atmospheric plasma glow discharge was used to change the characteristics of a 3D-type polymeric scaffold from hydrophobic to hydrophilic on both the outer and inner surfaces of the scaffold and the penetration efficiency with fibronectin was investigated. Field-emission scanning electron microscope images showed that some grooves were formed on the PLLA fibers after plasma treatment. X-ray photoelectron spectroscopy data also showed chemical changes in the PLLA structure. After plasma treatment, -CN (285.76 eV) was increased in C1s and -NH2 (399.70 eV) was increased significantly and -N=CH (400.80 eV) and -NH3+ (402.05 eV) were newly appeared in N1s. These changes allowed fibronectin to penetrate into the PLLA scaffold; this could be observed by confocal microscopy. In conclusion, helium atmospheric pressure plasma treatment was effective in modifying the polymeric scaffold, making it hydrophilic, and this treatment can also be used in tissue engineering research as needed to make polymers hydrophilic.

  1. Plasma treatment induces internal surface modifications of electrospun poly(L-lactic) acid scaffold to enhance protein coating

    SciTech Connect

    Jin Seo, Hyok; Hee Lee, Mi; Kwon, Byeong-Ju; Kim, Hye-Lee; Park, Jong-Chul; Jin Lee, Seung; Kim, Bong-Jin; Wang, Kang-Kyun; Kim, Yong-Rok

    2013-08-21

    Advanced biomaterials should also be bioactive with regard to desirable cellular responses, such as selective protein adsorption and cell attachment, proliferation, and differentiation. To enhance cell-material interactions, surface modifications have commonly been performed. Among the various surface modification approaches, atmospheric pressure glow discharge plasma has been used to change a hydrophobic polymer surface to a hydrophilic surface. Poly(L-lactic acid) (PLLA)-derived scaffolds lack cell recognition signals and the hydrophobic nature of PLLA hinders cell seeding. To make PLLA surfaces more conducive to cell attachment and spreading, surface modifications may be used to create cell-biomaterial interfaces that elicit controlled cell adhesion and maintain differentiated phenotypes. In this study, (He) gaseous atmospheric plasma glow discharge was used to change the characteristics of a 3D-type polymeric scaffold from hydrophobic to hydrophilic on both the outer and inner surfaces of the scaffold and the penetration efficiency with fibronectin was investigated. Field-emission scanning electron microscope images showed that some grooves were formed on the PLLA fibers after plasma treatment. X-ray photoelectron spectroscopy data also showed chemical changes in the PLLA structure. After plasma treatment, -CN (285.76 eV) was increased in C1s and -NH{sub 2} (399.70 eV) was increased significantly and –N=CH (400.80 eV) and –NH{sub 3}{sup +} (402.05 eV) were newly appeared in N1s. These changes allowed fibronectin to penetrate into the PLLA scaffold; this could be observed by confocal microscopy. In conclusion, helium atmospheric pressure plasma treatment was effective in modifying the polymeric scaffold, making it hydrophilic, and this treatment can also be used in tissue engineering research as needed to make polymers hydrophilic.

  2. An immersive “simulation week” enhances clinical performance of incoming surgical interns improved performance persists at 6 months follow-up

    PubMed Central

    Singh, Pritam; Aggarwal, Rajesh; Pucher, Philip H.; Hashimoto, Daniel A.; Beyer-Berjot, Laura; Bharathan, Rasiah; Middleton, Katherine E.; Jones, Joanne; Darzi, Ara

    2015-01-01

    Background The transition from student to intern can be challenging. The “August” or “July effect” describes increased errors and reduced patient safety during this transition. The study objectives were to develop, pilot, and evaluate clinical performance after an immersive simulation course for incoming interns. Methods Graduating students were recruited for a 1-week immersive simulation course. Controls received no simulation training. Primary outcome (at baseline, and 1 and 6 months) was clinical performance on Objective Structured Clinical Examinations (OSCE) of clinical procedures and surgical technical skills. Secondary outcomes were self-reported confidence and clinical procedure logbook data. Results Nineteen students were recruited. Sixteen completed the 6-month follow-up, 10 in the intervention group and 6 in the control group. No differences were demonstrated between interventions and controls at baseline (OSCE [median, 66 vs 78; P = .181], technical skills [48 vs 52.5; P = .381], and confidence [101 vs 96; P = .368]). Interventions outperformed controls at 1 month (OSCE [111 vs 82; P = .001], technical skills [78.5 vs 63; P = .030], and confidence [142 vs 119; P < .001]), and 6 months (OSCE [107 vs 93; P = .007], technical skills [92.5 vs 69; P = .044], and confidence [148 vs 129; P = .022]). No differences were observed in numbers of clinical procedures performed at 1 (P = .958), 4 (P = .093), or 6 months (P = .713). Conclusion The immersive simulation course objectively improved subjects’ clinical skills, technical skills, and confidence. Despite similar clinical experience as controls, the intervention group’s improved performance persisted at 6 months follow-up. This feasible and effective intervention to ease transition from student to intern could reduce errors and enhance patient safety. PMID:25633735

  3. Experimental investigation of certain internal condensing and boiling flows: Their sensitivity to pressure fluctuations and heat transfer enhancements

    NASA Astrophysics Data System (ADS)

    Kivisalu, Michael Toomas

    Space-based (satellite, scientific probe, space station, etc.) and millimeter -- to -- micro-scale (such as are used in high power electronics cooling, weapons cooling in aircraft, etc.) condensers and boilers are shear/pressure driven. They are of increasing interest to system engineers for thermal management because flow boilers and flow condensers offer both high fluid flow-rate-specific heat transfer capacity and very low thermal resistance between the fluid and the heat exchange surface, so large amounts of heat may be removed using reasonably-sized devices without the need for excessive temperature differences. However, flow stability issues and degredation of performance of shear/pressure driven condensers and boilers due to non-desireable flow morphology over large portions of their lengths have mostly prevented their use in these applications. This research is part of an ongoing investigation seeking to close the gap between science and engineering by analyzing two key innovations which could help address these problems. First, it is recommended that the condenser and boiler be operated in an innovative flow configuration which provides a non-participating core vapor stream to stabilize the annular flow regime throughout the device length, accomplished in an energy-efficient manner by means of ducted vapor re-circulation. This is demonstrated experimentally.. Second, suitable pulsations applied to the vapor entering the condenser or boiler (from the re-circulating vapor stream) greatly reduce the thermal resistance of the already effective annular flow regime. For experiments reported here, application of pulsations increased time-averaged heat-flux up to 900 % at a location within the flow condenser and up to 200 % at a location within the flow boiler, measured at the heat-exchange surface. Traditional fully condensing flows, reported here for comparison purposes, show similar heat-flux enhancements due to imposed pulsations over a range of frequencies

  4. Internal-Modified Dithiol DNA-Directed Au Nanoassemblies: Geometrically Controlled Self-Assembly and Quantitative Surface-Enhanced Raman Scattering Properties

    NASA Astrophysics Data System (ADS)

    Yan, Yuan; Shan, Hangyong; Li, Min; Chen, Shu; Liu, Jianyu; Cheng, Yanfang; Ye, Cui; Yang, Zhilin; Lai, Xuandi; Hu, Jianqiang

    2015-11-01

    In this work, a hierarchical DNA-directed self-assembly strategy to construct structure-controlled Au nanoassemblies (NAs) has been demonstrated by conjugating Au nanoparticles (NPs) with internal-modified dithiol single-strand DNA (ssDNA) (Au-B-A or A-B-Au-B-A). It is found that the dithiol-ssDNA-modified Au NPs and molecule quantity of thiol-modified ssDNA grafted to Au NPs play critical roles in the assembly of geometrically controlled Au NAs. Through matching Au-DNA self-assembly units, geometrical structures of the Au NAs can be tailored from one-dimensional (1D) to quasi-2D and 2D. Au-B-A conjugates readily give 1D and quasi-2D Au NAs while 2D Au NAs can be formed by A-B-Au-B-A building blocks. Surface-enhanced Raman scattering (SERS) measurements and 3D finite-difference time domain (3D-FDTD) calculation results indicate that the geometrically controllable Au NAs have regular and linearly “hot spots”-number-depended SERS properties. For a certain number of NPs, the number of “hot spots” and accordingly enhancement factor of Au NAs can be quantitatively evaluated, which open a new avenue for quantitative analysis based on SERS technique.

  5. Parametric study on heat transfer enhancement and pressure drop of an internal blade tip-wall with pin-fin arrays

    NASA Astrophysics Data System (ADS)

    Xie, Gongnan; Sundén, Bengt; Wang, Lieke; Utriainen, Esa

    2011-01-01

    One way to cool gas turbine tips is to design serpentine passages with 180° turns inside the blades to fully utilize the coolant potential. It is therefore a desire to improve the cooling of the blade tips to ensure a long durability and safe operation. In the present work, a two-pass channel with a 180° turn and various arrays of pin-fins mounted internally on the tip-cap is considered. The effects of pin-fin height, diameter and pitches on the heat transfer enhancement and pressure drop are investigated numerically. The nominal ratio of height to diameter (H/D) of the pin-fins is 2, and the ratio of tip clearance to pin-fin height is about 10. The inlet Reynolds numbers based on hydraulic diameter are ranging from 100,000 to 600,000. Details of the three dimensional fluid flow and heat transfer over the pin-finned tips are presented. The overall performances of various tips are compared. It is found that due to the combination of turning, impingement and pin-fin crossflow, the heat transfer coefficient of the pin-finned tips is up to a factor of 2.1 higher than that of the smooth tip. This augmentation is achieved at the expense of a penalty of pressure drop around 30%. Results show that the magnitude of the heat transfer enhancement depends upon pin-fin configuration and arrangement. It is suggested that pin-fins are suitable to enhance the blade tip heat transfer and thus to improve the tip cooling.

  6. Multifunctional PEGylated 2C5-Immunoliposomes Containing pH-sensitive Bonds and TAT Peptide for Enhanced Tumor Cell Internalization and Cytotoxicity

    PubMed Central

    Koren, Erez; Apte, Anjali; Jani, Ankur; Torchilin, Vladimir P.

    2012-01-01

    pH-sensitive PEGylated (with PEG-PE) long-circulating liposomes (HSPC:cholesterol and Doxil®), modified with cell-penetrating TAT peptide (TATp) moieties and cancer-specific mAb 2C5 were prepared. A degradable pH-sensitive hydrazone bond between a long shielding PEG chains and PE (PEG2k-Hz-PE) was introduced. TATp was conjugated with a short PEG1k-PE spacer and mAb 2C5 was attached to a long PEG chain (2C5-PEG3.4k-PE). The “shielding” effect of TATp by long PEG chains was investigated using three liposomal models. At normal pH, surface TATp moieties are “hidden” by the long PEG chains. Upon the exposure to lowered pH, this multifunctional carrier exposes TATp moieties after the degradation of the hydrazone bond and removal of the long PEG chains. Enhanced cellular uptake of the TATp-containing immunoliposomes was observed in vitro after pre-treatment at lowered pH (using flow cytometry and fluorescence microscopy techniques). The presence of mAb 2C5 on the liposome surface further enhanced the interaction between the carrier and tumor cells but not normal cells. Furthermore, multifunctional immuno-Doxil® preparation showed increased cellular cytotoxicity of B16-F10, HeLa and MCF-7 cells when pre-incubated at lower pH, indicating TATp exposure and activity. In conclusion, a multifunctional immunoliposomal nanocarrier containing a pH-sensitive PEG-PE component, TATp, and the cancer cell-specific mAb 2C5 promotes enhanced cytotoxicity and carrier internalization by cancer cells and demonstrates the potential for intracellular drug delivery after exposure to lowered pH environment, typical of solid tumors. PMID:22182771

  7. Multifunctional PEGylated 2C5-immunoliposomes containing pH-sensitive bonds and TAT peptide for enhanced tumor cell internalization and cytotoxicity.

    PubMed

    Koren, Erez; Apte, Anjali; Jani, Ankur; Torchilin, Vladimir P

    2012-06-10

    pH-sensitive PEGylated (with PEG-PE) long-circulating liposomes (HSPC:cholesterol and Doxil®), modified with cell-penetrating TAT peptide (TATp) moieties and cancer-specific mAb 2C5 were prepared. A degradable pH-sensitive hydrazone bond between a long shielding PEG chains and PE (PEG(2k)-Hz-PE) was introduced. TATp was conjugated with a short PEG(1k)-PE spacer and mAb 2C5 was attached to a long PEG chain (2C5-PEG(3.4k)-PE). The "shielding" effect of TATp by long PEG chains was investigated using three liposomal models. At normal pH, surface TATp moieties are "hidden" by the long PEG chains. Upon the exposure to lowered pH, this multifunctional carrier exposes TATp moieties after the degradation of the hydrazone bond and removal of the long PEG chains. Enhanced cellular uptake of the TATp-containing immunoliposomes was observed in vitro after pre-treatment at lowered pH (using flow cytometry and fluorescence microscopy techniques). The presence of mAb 2C5 on the liposome surface further enhanced the interaction between the carrier and tumor cells but not normal cells. Furthermore, multifunctional immuno-Doxil® preparation showed increased cellular cytotoxicity of B16-F10, HeLa and MCF-7 cells when pre-incubated at lower pH, indicating TATp exposure and activity. In conclusion, a multifunctional immunoliposomal nanocarrier containing a pH-sensitive PEG-PE component, TATp, and the cancer cell-specific mAb 2C5 promotes enhanced cytotoxicity and carrier internalization by cancer cells and demonstrates the potential for intracellular drug delivery after exposure to lowered pH environment, typical of solid tumors. PMID:22182771

  8. Measuring the morphology and density of internally mixed black carbon with SP2 and VTDMA: new insight into the absorption enhancement of black carbon in the atmosphere

    NASA Astrophysics Data System (ADS)

    Zhang, Yuxuan; Zhang, Qiang; Cheng, Yafang; Su, Hang; Kecorius, Simonas; Wang, Zhibin; Wu, Zhijun; Hu, Min; Zhu, Tong; Wiedensohler, Alfred; He, Kebin

    2016-04-01

    The morphology and density of black carbon (BC) cores in internally mixed BC (In-BC) particles affect their mixing state and absorption enhancement. In this work, we developed a new method to measure the morphology and effective density of the BC cores of ambient In-BC particles using a single-particle soot photometer (SP2) and a volatility tandem differential mobility analyzer (VTDMA) during the CAREBeijing-2013 campaign from 8 to 27 July 2013 at Xianghe Observatory. This new measurement system can select size-resolved ambient In-BC particles and measure the mobility diameter and mass of the In-BC cores. The morphology and effective density of the ambient In-BC cores are then calculated. For the In-BC cores in the atmosphere, changes in their dynamic shape factor (χ) and effective density (ρeff) can be characterized as a function of the aging process (Dp/Dc) measured by SP2 and VTDMA. During an intensive field study, the ambient In-BC cores had an average shape factor χ of ˜ 1.2 and an average density of ˜ 1.2 g cm-3, indicating that ambient In-BC cores have a near-spherical shape with an internal void of ˜ 30 %. From the measured morphology and density, the average shell / core ratio and absorption enhancement (Eab) of ambient BC were estimated to be 2.1-2.7 and 1.6-1.9, respectively, for In-BC particles with sizes of 200-350 nm. When the In-BC cores were assumed to have a void-free BC sphere with a density of 1.8 g cm-3, the shell / core ratio and Eab were overestimated by ˜ 13 and ˜ 17 %, respectively. The new approach developed in this work improves the calculations of the mixing state and optical properties of ambient In-BC particles by quantifying the changes in the morphology and density of ambient In-BC cores during aging.

  9. Enhancing capacities of riparian professionals to address and resolve transboundary issues in international river basins: experiences from the Lower Mekong River Basin

    NASA Astrophysics Data System (ADS)

    Douven, W.; Mul, M. L.; Álvarez, B. F.; Son, L. H.; Bakker, N.; Radosevich, G.; van der Zaag, P.

    2012-03-01

    This paper analyses the design and impact of capacity building programmes aimed at enhancing capacities of riparian professionals to address and resolve transboundary issues in international river basins. Case study is a programme developed by the Mekong River Commission (MRC). A post training evaluation was applied to assess its impact in terms of individual capacity enhancement and change (use and application of knowledge, factors hampering application, and change in function and opportunities within their organisation). The design of the Capacity Building Programme of the MRC Flood Management and Mitigation Programme showed a well balanced range of subjects (such as IWRM, models and decision support systems and international water law) which are required for such an integrated topic. The post training evaluation, 6 months after the last training workshop, showed the increase in familiarity of the topics for all 37 respondents, with highest increase for the respondents with few years of working experience and from training and educational institutions. The relevance of the subjects taught is shown by the fact that 95% of the respondents indicated they saw the relevance of the subjects and 78% had already used some knowledge acquired in their job. The respondents also indicated that they did not have sufficient opportunities to apply all knowledge acquired. The phased implementation and training of lecturers during the training workshops, had a good impact, directly through increasing involvement in facilitation and delivery of the capacity building programme and through the use of the knowledge gained in short courses and development of curricula at their training institute. For these types of capacity building programmes, a few recommendations can be made. The selection of participants is crucial for the application of the learned knowledge in their work. The integrative nature of transboundary water issues calls for a capacity building programme addressing a

  10. Dilute nitride resonant cavity enhanced photodetector with internal gain for the λ ∼ 1.3 μm optical communications window

    NASA Astrophysics Data System (ADS)

    Balkan, N.; Erol, A.; Sarcan, F.; Al-Ghuraibawi, L. F. F.; Nordin, M. S.

    2015-10-01

    We report on a novel dilute nitride-based resonant cavity enhanced photodetector (RCEPD) operating at 1.286 μm. The RCEPD was fabricated using 21 pairs top and 24 pairs bottom GaAs/AlGaAs distributed Bragg reflectors for mirrors and 7 nm thick nine GaAs/Ga0.65In0.35N0.02 As0.98 quantum wells as the absorption region. For a 15 μm diameter window, the photocurrent at 1.286 μm is 27 μA and 42 μA, at V = 0 and -1 V, respectively, whereas the dark current is as low as 1.7 nA at -1 V. At the operating wavelength, an excellent wavelength selectivity with a full width at half maximum (FWHM) of 5 nm, and a high quantum efficiency of 43% are demonstrated. The device exhibits significant internal gain at very small reverse bias voltages of V ⩾ -2 V with an overall quantum efficiency of 67%. These are the best ever recorded values for a dilute nitride RCEPD.

  11. Enhanced capture of healthcare-related harms and injuries in the 11th revision of the International Classification of Diseases (ICD-11).

    PubMed

    Southern, Danielle A; Pincus, Harold A; Romano, Patrick S; Burnand, Bernard; Harrison, James; Forster, Alan J; Moskal, Lori; Quan, Hude; Droesler, Saskia E; Sundararajan, Vijaya; Colin, Cyrille; Gurevich, Yana; Brien, Susan E; Kostanjsek, Nenad; Üstün, Bedirhan; Ghali, William A

    2016-02-01

    The World Health Organization (WHO) plans to submit the 11th revision of the International Classification of Diseases (ICD) to the World Health Assembly in 2018. The WHO is working toward a revised classification system that has an enhanced ability to capture health concepts in a manner that reflects current scientific evidence and that is compatible with contemporary information systems. In this paper, we present recommendations made to the WHO by the ICD revision's Quality and Safety Topic Advisory Group (Q&S TAG) for a new conceptual approach to capturing healthcare-related harms and injuries in ICD-coded data. The Q&S TAG has grouped causes of healthcare-related harm and injuries into four categories that relate to the source of the event: (a) medications and substances, (b) procedures, (c) devices and (d) other aspects of care. Under the proposed multiple coding approach, one of these sources of harm must be coded as part of a cluster of three codes to depict, respectively, a healthcare activity as a 'source' of harm, a 'mode or mechanism' of harm and a consequence of the event summarized by these codes (i.e. injury or harm). Use of this framework depends on the implementation of a new and potentially powerful code-clustering mechanism in ICD-11. This new framework for coding healthcare-related harm has great potential to improve the clinical detail of adverse event descriptions, and the overall quality of coded health data.

  12. International Perspectives on Fieldcourses.

    ERIC Educational Resources Information Center

    Nairn, Karen; Higgitt, David; Vanneste, Dominique

    2000-01-01

    Considers the context of internationalism for the enhancement of fieldwork practices. Discusses whether fieldcourses are valuable experiences. Addresses specific issues affecting internationalisation of fieldcourses, such as financial considerations, sharing courses (staff and resources), overseas fieldtrips and expeditions, safety, and student…

  13. Characterization of focal liver lesions with SonoVue®-enhanced sonography: International multicenter-study in comparison to CT and MRI

    PubMed Central

    Trillaud, Hervé; Bruel, Jean-Michel; Valette, Pierre-Jean; Vilgrain, Valérie; Schmutz, Gérard; Oyen, Raymond; Jakubowski, Wieslaw; Danes, Jan; Valek, Vlastimil; Greis, Christian

    2009-01-01

    AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVue®-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrast-enhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The final diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue® markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVue®-enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specificity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specificity of CEUS for the identification of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVue®-enhanced sonography emerges as the most sensitive, most specific and thus most accurate imaging modality for the characterization of focal liver lesions. PMID:19673015

  14. The enhanced Aussie Optimism Positive Thinking Skills Program: The relationship between internalizing symptoms and family functioning in children aged 9–11 years old

    PubMed Central

    Kennedy, Patricia; Rooney, Rosanna M.; Kane, Robert T.; Hassan, Sharinaz; Nesa, Monique

    2015-01-01

    The family context plays a critical role in the health of the child. This was the first study to examine the usefulness of the General Functioning subscale of the Family Assessment Device (FAD-GF) in assessing family functioning and its relationship to internalizing symptoms in school-aged children aged between 9 and 11 years of age. Eight hundred and forty-seven year 4 and 5 students from 13 schools (607 intervention students, and 240 control students) participated in the Aussie Optimism Positive Thinking Skills Program (AO-PTS) – a universal school-based program targeting internalizing symptoms. Students rated how ‘healthy’ they perceived their family to be at pre-test and at 6-months follow-up. Although some aspects of validity and reliability could be improved, results indicated that perceptions of family functioning at pre-test were predictive of internalizing symptoms at the 6-months follow-up. The FAD-GF therefore showed promise as a potential measure of family functioning for children as young as 9 years old. Regardless of children’s pre-test levels of perceived family functioning, no intervention effects were found on the anxiety and depression scales; this finding suggests that child perceptions of family functioning may act as a general protective factor against internalizing symptomology. PMID:25983698

  15. SIB-DOTA: A trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies

    PubMed Central

    Vaidyanathan, G.; White, B. J.; Affleck, D.J.; Zhao, X.G.; Welsh, P.C.; McDougald, D.; Choi, J.; Zalutsky, M. R.

    2012-01-01

    A major drawback of internalizing monoclonal antibodies (mAbs) radioiodinated with direct electrophilic approaches is that tumor retention of radioactivity is compromised by the rapid washout of iodo-tyrosine, the primary labeled catabolite for mAbs labeled via this strategy. In our continuing efforts to develop more versatile residualizing labels that could overcome this problem, we have designed SIB-DOTA, a prosthetic labeling template that combines the features of the prototypical, dehalogenation resistant N-succinimidyl 3-iodobenzoate (SIB) with DOTA, a useful macrocyclic chelator for labeling with radiometals. Herein we describe the synthesis of the unlabeled standard of this prosthetic moiety, its protected tin precursor, and radioiodinated SIB-DOTA. An anti-EGFRvIII-reactive mAb, L8A4 was radiolabeled with [131I]SIB-DOTA in 27.1 ± 6.2% (n = 2) conjugation yields and its targeting properties to the same mAb labeled with [125I]SGMIB both in vitro and in vivo using U87MG·ΔEGFR cells and xenografts were compared. In vitro paired-label internalization assays showed that the intracellular radioactivity from [131I]SIB-DOTA-L8A4 was 21.4 ± 0.5% and 26.2 ± 1.1% of initially bound radioactivity at 16 and 24 h, respectively. In comparison, these values for [125I]SGMIB-L8A4 were 16.7 ± 0.5% and 14.9 ± 1.1%. Similarly, the SIB-DOTA prosthetic group provided better tumor targeting in vivo than SGMIB over 8 d period. These results suggest that SIB-DOTA warrants further evaluation as a residualizing agent for labeling internalizing mAbs including those targeted to EGFRvIII. PMID:23159039

  16. Efficient enhancement of internal proton transfer of branched π-extended organic chromophore under one-photon and near-infrared two-photon irradiation

    NASA Astrophysics Data System (ADS)

    Gong, Yulong; Lu, Yao; Ma, Huiying; Ding, Ge; Zhang, Shengtao; Luo, Ziping; Li, Hongru; Gao, Fang

    2015-01-01

    The new branched π-extended conjugated triphenylamine-based organic chromophores bearing with proton transfer segments were synthesized. Internal H-bonding effect in the ground state of these new π-extended chromophores is demonstrated by X-ray single crystal diffraction, 1H NMR spectra and UV-vis spectroscopy. Intramolecular proton transfer in the excited singlet state of the enlarged organic chromophore is greatly increased by the branched structure under one-photo and near-infrared two-photon excitation respectively. The fundamental mechanism of intramolecular proton transfer in the excited state was preliminarily revealed by the potential energy barrier computation of enol-keto phototautomerization.

  17. Downregulation of internal enhancer activity contributes to abnormally low immunoglobulin expression in the MedB-1 mediastinal B-cell lymphoma cell line.

    PubMed

    Ritz, Olga; Leithäuser, Frank; Hasel, Cornelia; Brüderlein, Silke; Ushmorov, Alexey; Möller, Peter; Wirth, Thomas

    2005-02-01

    Primary mediastinal B-cell lymphoma (PMBL) is a highly aggressive tumour with a unique pattern of clinical, morphological, immunological and genetic features distinct from other diffuse large B-cell lymphomas. PMBLs are characterized by a mature B-cell phenotype, but they typically lack immunoglobulin (Ig) gene expression. The PMBL cell line MedB-1 shares many characteristic properties of the primary tumour, including low-level Ig production despite a functionally rearranged IgVH gene and absence of 'crippling' mutations. In this study, a search was undertaken for reasons for downregulated Ig expression. Similar levels of the B-cell-specific transcription factors BOB.1/OBF.1 and PU.1 were found in MedB-1 cells to those in the Ig-producing UM-1 lymphoblastoid cell line. However, MedB-1 lacked the Oct2 transcription factor. Reporter assays showed that Ig-type promoters were active in MedB-1 cells. In contrast, activity of the intronic heavy chain enhancer was dramatically reduced. Ectopic expression of Oct2 was able partially to restore enhancer activity but transcription from the endogenous IgVH gene could not be rescued. Therefore, the role of epigenetic factors in the downregulation of Ig was investigated. Methylated histone 3 lysine 9, a reliable marker of chromatin silencing, was not detected in MedB-1 promoter and enhancer regions. Inhibition of DNA methyltransferase and of histone deacetylases also did not reactivate Ig production. These data suggest the existence of alternative mechanisms of Ig inhibition in MedB-1 cells, different from chromatin silencing and the lack of Oct2. PMID:15682441

  18. International Reports.

    ERIC Educational Resources Information Center

    Valauskas, Edward J.; Crosby, John, IV; Haycock, Ken; Oh, Mary

    1999-01-01

    Includes the following international reports: International Federation of Library Associations and Institutions; Special Libraries Association; and Trends and Issues in Library and Information Services in Canada, 1998. (AEF)

  19. Internal multiple-scattering hole-enhanced Raman spectroscopy: improved backscattering Fourier transform Raman sampling in pharmaceutical tablets utilizing cylindrical-conical holes.

    PubMed

    Larkin, Peter J; Santangelo, Matthew; Šašiċ, Slobodan

    2012-08-01

    The benefits of Raman signal enhancement and improved measurement precision are demonstrated using 180° backscattering Fourier transform Raman (FT-Raman) spectroscopy from drilled cylindrical-conical holes within pharmaceutical tablet cores. Multiple scattering of the incident laser light within the holes results in an increased Raman signal due to the larger Raman sampling volume. This is important for overcoming typical sub-sampling issues encountered when employing FT-Raman backscattering of heterogeneous pharmaceutical tablets. Hole depth and diameter were found to be important experimental parameters and were optimized to yield the greatest signal enhancement. The FT-Raman spectra collected using backscattering from cylindrical-conical holes is compared to typical 180° backscattering from flat surfaces using tablet cores of Excedrin® and Vivarin®. Raman chemical images are used to establish a representative sampling area. We observe a three- to five-fold increase in the Raman intensity and a two-fold improvement in the measurement precision when sampling from cylindrical-conical holes rather than classic backscattering from flat tablet cores. Self-absorption effects on analyte band ratios are negligible in the fingerprint region but are more significant at the higher near-infrared (NIR) absorbances found in the C-H/O-H/-N-H stretching region. The sampling technique will facilitate developing quantitative FT-Raman methods for application to pharmaceutical tablets using the fingerprint spectral region.

  20. Internal-Modified Dithiol DNA–Directed Au Nanoassemblies: Geometrically Controlled Self–Assembly and Quantitative Surface–Enhanced Raman Scattering Properties

    PubMed Central

    Yan, Yuan; Shan, Hangyong; Li, Min; Chen, Shu; Liu, Jianyu; Cheng, Yanfang; Ye, Cui; Yang, Zhilin; Lai, Xuandi; Hu, Jianqiang

    2015-01-01

    In this work, a hierarchical DNA–directed self–assembly strategy to construct structure–controlled Au nanoassemblies (NAs) has been demonstrated by conjugating Au nanoparticles (NPs) with internal–modified dithiol single-strand DNA (ssDNA) (Au–B–A or A–B–Au–B–A). It is found that the dithiol–ssDNA–modified Au NPs and molecule quantity of thiol–modified ssDNA grafted to Au NPs play critical roles in the assembly of geometrically controlled Au NAs. Through matching Au–DNA self–assembly units, geometrical structures of the Au NAs can be tailored from one–dimensional (1D) to quasi–2D and 2D. Au–B–A conjugates readily give 1D and quasi–2D Au NAs while 2D Au NAs can be formed by A–B–Au–B–A building blocks. Surface-enhanced Raman scattering (SERS) measurements and 3D finite–difference time domain (3D-FDTD) calculation results indicate that the geometrically controllable Au NAs have regular and linearly “hot spots”–number–depended SERS properties. For a certain number of NPs, the number of “hot spots” and accordingly enhancement factor of Au NAs can be quantitatively evaluated, which open a new avenue for quantitative analysis based on SERS technique. PMID:26581251

  1. IGSN at Work in the Land Down Under: Exploiting an International Sample Identifier System to Enhance Reproducibility of Australian Geochemcial and Geochronological Data.

    NASA Astrophysics Data System (ADS)

    Bastrakova, I.; Klump, J. F.; McInnes, B.; Wyborn, L. A.; Brown, A.

    2015-12-01

    The International Geo-Sample Number (IGSN) provides a globally unique identifier for physical samples used to generate analytical data. This unique identifier provides the ability to link each physical sample to any analytical data undertaken on that sample, as well as to any publications derived from any data derived on the sample. IGSN is particularly important for geochemical and geochronological data, where numerous analytical techniques can be undertaken at multiple analytical facilities not only on the parent rock sample itself, but also on derived sample splits and mineral separates. Australia now has three agencies implementing IGSN: Geoscience Australia, CSIRO and Curtin University. All three have now combined into a single project, funded by the Australian Research Data Services program, to better coordinate the implementation of IGSN in Australia, in particular how these agencies allocate IGSN identifiers. The project will register samples from pilot applications in each agency including the CSIRO National Collection of Mineral Spectra database, the Geoscience Australia sample collection, and the Digital Mineral Library of the John De Laeter Centre for Isotope Research at Curtin University. These local agency catalogues will then be aggregated into an Australian portal, which will ultimately be expanded for all geoscience specimens. The development of this portal will also involve developing a common core metadata schema for the description of Australian geoscience specimens, as well as formulating agreed governance models for registering Australian samples. These developments aim to enable a common approach across Australian academic, research organisations and government agencies for the unique identification of geoscience specimens and any analytical data and/or publications derived from them. The emerging pattern of governance and technical collaboration established in Australia may also serve as a blueprint for similar collaborations internationally.

  2. Enhancing quality and integrity in biomedical research in Africa: an international call for greater focus, investment and standardisation in capacity strengthening for frontline staff.

    PubMed

    Kombe, Francis

    2015-01-01

    The integrity of biomedical research depends heavily on the quality of research data collected. In turn, data quality depends on processes of data collection, a task undertaken by frontline research staff in many research programmes in Africa and elsewhere. These frontline research staff often have additional responsibilities including translating and communicating research in local languages, seeking informed consent for study participation and maintaining supportive relationships between research institutions and study participants and wider communities. The level of skills that fieldworkers need to undertake these responsibilities clearly affects the quality of data collected, the ethics of research 'on the ground' and the short and long term acceptability of research.We organised an international workshop in Kenya in July 2014 to discuss the role of frontline staff in scientific research. A total of 25 field managers from 9 African countries and the UK met for 2.5 days to discuss the relationship between data quality and institutional performance management systems and how they affect career progression and supportive supervision policies of research frontline staff.From this workshop, and supporting an expanding literature on the role of fieldworkers in international health research, participants agreed that fieldworkers' roles present them with practical and ethical challenges that their routine training does not adequately prepare them for. We argue that the common and complex challenges facing fieldworkers should in part be addressed through increased investment and collaborative agreements across types of research institutions in Africa. We call for standardization of core elements of training for this critically important cadre of research staff who perform similar roles and encounter similar challenges in many African settings. Although many valuable training elements are offered in institutions, there is a need to develop broader, more grounded and

  3. Quantitative determination of H2, HD, and D2 internal-state distributions by (2+1) resonance-enhanced multiphoton ionization

    NASA Astrophysics Data System (ADS)

    Rinnen, Klaus-Dieter; Buntine, Mark A.; Kliner, Dahv A. V.; Zare, Richard N.; Huo, Winifred M.

    1991-07-01

    Results are presented of an experimental study of (2+1) resonance-enhanced multiphoton ionization (REMPI) detection of H2, HD, and D2 via the E,F two-photon transition, in which the relationship between ion signals and quantum-state populations was determined by calibration against a thermal effusive source. Vibrational and rotational correction factors were obtained for 102 rovibrational levels for v-double-prime = 0, 1, and 2 and for J-double-prime ranging from 0 to 17. These correction factors make it possible to convert ion signals into relative quantum-state populations without relying on a theoretical description of the (2+1) REMPI process.

  4. Quantitative determination of H2, HD, and D2 internal-state distributions by (2+1) resonance-enhanced multiphoton ionization

    NASA Technical Reports Server (NTRS)

    Rinnen, Klaus-Dieter; Buntine, Mark A.; Kliner, Dahv A. V.; Zare, Richard N.; Huo, Winifred M.

    1991-01-01

    Results are presented of an experimental study of (2+1) resonance-enhanced multiphoton ionization (REMPI) detection of H2, HD, and D2 via the E,F two-photon transition, in which the relationship between ion signals and quantum-state populations was determined by calibration against a thermal effusive source. Vibrational and rotational correction factors were obtained for 102 rovibrational levels for v-double-prime = 0, 1, and 2 and for J-double-prime ranging from 0 to 17. These correction factors make it possible to convert ion signals into relative quantum-state populations without relying on a theoretical description of the (2+1) REMPI process.

  5. A Crucial Role of Rh Substituent Ion in Photoinduced Internal Electron Transfer and Enhanced Photocatalytic Activity of CdS-Ti(5.2-x)/6 Rhx /2 O2 Nanohybrids.

    PubMed

    Lee, Jang Mee; Jin, Hyung Bin; Kim, In Young; Jo, Yun Kyung; Hwang, Jung-Wook; Wang, Kang-Kyun; Kim, Min Gyu; Kim, Yong-Rok; Hwang, Seong-Ju

    2015-11-18

    The photocatalytic activity and photostability of CdS quantum dot (QD) can be remarkably enhanced by hybridization with Rh-substituted layered titanate nanosheet even at very low Rh substitution rate (<1%). Mesoporous CdS-Ti(5.2-x)/6 Rhx/2O2 nanohybrids are synthesized by a self-assembly of exfoliated Ti(5.2-x)/6 Rhx/2O2 nanosheets with CdS QDs. The partial substitution of Rh(3+)/Rh(4+) ions for Ti(4+) ions in layered titanate is quite effective in enhancing an electronic coupling between hybridized CdS and titanate components via the formation of interband Rh 4d states. A crucial role of Rh substituent ion in the internal electron transfer is obviously evidenced from in situ X-ray absorption spectroscopy showing the elongation of (RhO) bond under visible light irradiation. This is the first spectroscopic evidence for the important role of substituent ion in the photoinduced electron transfer of hybrid-type photocatalyst. The CdS-Ti(5.2-x)/6 Rhx/2O2 nanohybrids show much higher photocatalytic activity for H2 production and better photostability than do CdS and unsubstituted CdS-TiO2 nanohybrid. This result is ascribable to the enhancement of visible light absorptivity, the depression of electron-hole recombination, and the enhanced hole curing of CdS upon Rh substitution. The present study underscores that the hybridization with composition-controlled inorganic nanosheet provides a novel efficient methodology to optimize the photo-related functionalities of semiconductor nanocrystal. PMID:26456493

  6. ARC-1, a sequence element complementary to an internal 18S rRNA segment, enhances translation efficiency in plants when present in the leader or intercistronic region of mRNAs

    PubMed Central

    Akbergenov, R. Zh.; Zhanybekova, S. Sh.; Kryldakov, R. V.; Zhigailov, A.; Polimbetova, N. S.; Hohn, T.; Iskakov, B. K.

    2004-01-01

    The sequences of different plant viral leaders with known translation enhancer ability show partial complementarity to the central region of 18S rRNA. Such complementarity might serve as a means to attract 40S ribosomal subunits and explain in part the translation-enhancing property of these sequences. To verify this notion, we designed β-glucuronidase (GUS) mRNAs differing only in the nature of 10 nt inserts in the center of their 41 base leaders. These were complementary to consecutive domains of plant 18S rRNA. Sucrose gradient analysis revealed that leaders with inserts complementary to regions 1105–1114 and 1115–1124 (‘ARC-1’) of plant 18S rRNA bound most efficiently to the 40S ribosomal subunit after dissociation from 80S ribosomes under conditions of high ionic strength, a treatment known to remove translation initiation factors. Using wheat germ cell-free extracts, we could demonstrate that mRNAs with these leaders were translated more than three times more efficiently than a control lacking such a complementarity. Three linked copies of the insert enhanced translation of reporter mRNA to levels comparable with those directed by the natural translation enhancing leaders of tobacco mosaic virus and potato virus Y RNAs. Moreover, inserting the same leaders as intercistronic sequences in dicistronic mRNAs substantially increased translation of the second cistron, thereby revealing internal ribosome entry site activity. Thus, for plant systems, the complementary interaction between mRNA leader and the central region of 18S rRNA allows cap-independent binding of mRNA to the 43S pre-initiation complex without assistance of translation initiation factors. PMID:14718549

  7. A Facile and Low-Cost Method to Enhance the Internal Quantum Yield and External Light-Extraction Efficiency for Flexible Light-Emitting Carbon-Dot Films

    NASA Astrophysics Data System (ADS)

    Jiang, Z. C.; Lin, T. N.; Lin, H. T.; Talite, M. J.; Tzeng, T. T.; Hsu, C. L.; Chiu, K. P.; Lin, C. A. J.; Shen, J. L.; Yuan, C. T.

    2016-01-01

    Solution-processed, non-toxic carbon dots (CDs) have attracted much attention due to their unique photoluminescence (PL) properties. They are promising emissive layers for flexible light-emitting devices. To this end, the CDs in pristine aqueous solutions need to be transferred to form solid-state thin films without sacrificing their original PL characteristics. Unfortunately, solid-state PL quenching induced by extra non-radiative (NR) energy transfer among CDs would significantly hinder their practical applications in optoelectronics. Here, a facile, low-cost and effective method has been utilized to fabricate high-performance CD/polymer light-emitting flexible films with submicron-structured patterns. The patterned polymers can serve as a solid matrix to disperse and passivate CDs, thus achieving high internal quantum yields of 61%. In addition, they can act as an out-coupler to mitigate the waveguide-mode losses, approximately doubling the external light-extraction efficiency. Such CD/polymer composites also exhibit good photo-stability, and thus can be used as eco-friendly, low-cost phosphors for solid-state lighting.

  8. A Facile and Low-Cost Method to Enhance the Internal Quantum Yield and External Light-Extraction Efficiency for Flexible Light-Emitting Carbon-Dot Films

    PubMed Central

    Jiang, Z. C.; Lin, T. N.; Lin, H. T.; Talite, M. J.; Tzeng, T. T.; Hsu, C. L.; Chiu, K. P.; Lin, C. A. J.; Shen, J. L.; Yuan, C. T.

    2016-01-01

    Solution-processed, non-toxic carbon dots (CDs) have attracted much attention due to their unique photoluminescence (PL) properties. They are promising emissive layers for flexible light-emitting devices. To this end, the CDs in pristine aqueous solutions need to be transferred to form solid-state thin films without sacrificing their original PL characteristics. Unfortunately, solid-state PL quenching induced by extra non-radiative (NR) energy transfer among CDs would significantly hinder their practical applications in optoelectronics. Here, a facile, low-cost and effective method has been utilized to fabricate high-performance CD/polymer light-emitting flexible films with submicron-structured patterns. The patterned polymers can serve as a solid matrix to disperse and passivate CDs, thus achieving high internal quantum yields of 61%. In addition, they can act as an out-coupler to mitigate the waveguide-mode losses, approximately doubling the external light-extraction efficiency. Such CD/polymer composites also exhibit good photo-stability, and thus can be used as eco-friendly, low-cost phosphors for solid-state lighting. PMID:26822337

  9. A Facile and Low-Cost Method to Enhance the Internal Quantum Yield and External Light-Extraction Efficiency for Flexible Light-Emitting Carbon-Dot Films.

    PubMed

    Jiang, Z C; Lin, T N; Lin, H T; Talite, M J; Tzeng, T T; Hsu, C L; Chiu, K P; Lin, C A J; Shen, J L; Yuan, C T

    2016-01-01

    Solution-processed, non-toxic carbon dots (CDs) have attracted much attention due to their unique photoluminescence (PL) properties. They are promising emissive layers for flexible light-emitting devices. To this end, the CDs in pristine aqueous solutions need to be transferred to form solid-state thin films without sacrificing their original PL characteristics. Unfortunately, solid-state PL quenching induced by extra non-radiative (NR) energy transfer among CDs would significantly hinder their practical applications in optoelectronics. Here, a facile, low-cost and effective method has been utilized to fabricate high-performance CD/polymer light-emitting flexible films with submicron-structured patterns. The patterned polymers can serve as a solid matrix to disperse and passivate CDs, thus achieving high internal quantum yields of 61%. In addition, they can act as an out-coupler to mitigate the waveguide-mode losses, approximately doubling the external light-extraction efficiency. Such CD/polymer composites also exhibit good photo-stability, and thus can be used as eco-friendly, low-cost phosphors for solid-state lighting. PMID:26822337

  10. Strategic information is everyone's business: perspectives from an international stakeholder meeting to enhance strategic information data along the HIV Cascade for people who inject drugs.

    PubMed

    Pierce, Richard D; Hegle, Jennifer; Sabin, Keith; Agustian, Edo; Johnston, Lisa G; Mills, Stephen; Todd, Catherine S

    2015-10-16

    People who inject drugs (PWID) are at increased HIV transmission risk because of unsafe injecting practices and a host of other individual, network, and structural factors. Thus, PWID have a great need for services within the Cascade of HIV prevention, diagnosis, care, and treatment (HIV Cascade). Yet the systems that monitor their progress through the Cascade are often lacking. Subsequently, fewer reliable data are available to guide programs targeting this key population (KP). Programmatic data, which are helpful in tracking PWID through the Cascade, also are limited because not all countries have harm reduction programming from which to estimate Cascade indicators. Also, due to stigma and the illegal nature of drug use, PWID may not disclose their drug use behavior or HIV status when accessing services. Consequently, PWID appear to have low HIV testing rates and, for those living with HIV, lower access to health services and lower viral suppression rates than do other KP groups. This commentary, based on outcomes from an international stakeholder meeting, identifies data gaps and proposes solutions to strengthen strategic information (SI), the systematic collection, analysis, and dissemination of information, to optimize HIV prevention, care, and treatment programming for PWID.

  11. Enhanced assimilation rate and water use efficiency with latitude through increased photosynthetic capacity and internal conductance in balsam poplar (Populus balsamifera L.).

    PubMed

    Soolanayakanahally, Raju Y; Guy, Robert D; Silim, Salim N; Drewes, Eric C; Schroeder, William R

    2009-12-01

    In outdoor common gardens, high latitude populations of deciduous tree species often display higher assimilation rates (A) than low latitude populations, but they accomplish less height. To test whether trends in A reflect adaptation to growing season length or, alternatively, are garden growth artefacts, we examined variation in height increment and ecophysiological traits in a range-wide collection of Populus balsamifera L. populations from 21 provenances, during unconstrained growth in a greenhouse. Rooted cuttings, maintained without resource limitation under 21 h photoperiod for 90 d, displayed increasing height growth, A, leaf mass per area and leaf N per area with latitude whereas stomatal conductance (g(s)) showed no pattern. Water-use efficiency as indicated by both gas exchange and delta(13)C increased with latitude, whereas photosynthetic nitrogen-use efficiency decreased. Differences in delta(13)C were less than expected based on A/g(s), suggesting coextensive variation in internal conductance (g(m)). Analysis of A-C(i) curves on a subset of populations showed that high latitude genotypes had greater g(m) than low-latitude genotypes. We conclude that higher peak rates of height growth in high latitude genotypes of balsam poplar are supported by higher A, achieved partly through higher g(m), to help compensate for a shorter growing season.

  12. Angular and internal state distributions of H2 (+) generated by (2 + 1) resonance enhanced multiphoton ionization of H2 using time-of-flight mass spectrometry.

    PubMed

    Perreault, William E; Mukherjee, Nandini; Zare, Richard N

    2016-06-01

    We report direct measurement of the anisotropy parameter β for the angular distribution of the photoelectron and photoion in (2 + 1) resonance enhanced multiphoton ionization process of H2 X (1)Σg (+) (v = 0, J = 0) molecules through the intermediate H2 E,F (1)Σg (+) (v' = 0, J' = 0) level (λ = 201.684 nm) using a time-of-flight mass spectrometer. The time-of-flight spectra were recorded as the direction of polarization of the ionizing laser was varied with respect to the flight axis of the H2 molecular beam and were fitted to an angular distribution in an appropriately rotated coordinate system with the z-axis oriented along the time-of-flight axis. The anisotropy parameter β was found to be 1.72 ± 0.13 by fitting the time-of-flight spectra and agreed with previous measurements. Using secondary ionization with a delayed laser pulse of different wavelength, we also determined the vibrational energy distribution of the ions, showing that 98% ± 4% of the ions are generated in their ground vibrational state, in agreement with the calculated Franck-Condon factors between the H2 E,F (1)Σg (+) (v' = 0) and H2 (+) X (1)Σg (+) (v″) vibrational levels.

  13. Using the Enhanced Daily Load Stimulus Model to Quantify the Mechanical Load and Bone Mineral Density Changes Experienced by Crew Members on the International Space Station

    NASA Technical Reports Server (NTRS)

    Genc, K. O.; Gopalakrishnan, R.; Kuklis, M. M.; Maender, C. C.; Rice, A. J.; Cavanagh, P. R.

    2009-01-01

    Despite the use of exercise countermeasures during long-duration space missions, bone mineral density (BMD) and predicted bone strength of astronauts continue to show decreases in the lower extremities and spine. This site-specific bone adaptation is most likely caused by the effects of microgravity on the mechanical loading environment of the crew member. There is, therefore, a need to quantify the mechanical loading experienced on Earth and on-orbit to define the effect of a given "dose" of loading on bone homeostasis. Gene et al. recently proposed an enhanced DLS (EDLS) model that, when used with entire days of in-shoe forces, takes into account recently developed theories on the importance of factors such as saturation, recovery, and standing and their effects on the osteogenic response of bone to daily physical activity. This algorithm can also quantify the tinting and type of activity (sit/unload, stand, walk, run or other loaded activity) performed throughout the day. The purpose of the current study was to use in-shoe force measurements from entire typical work days on Earth and on-orbit in order to quantify the type and amount of loading experienced by crew members. The specific aim was to use these measurements as inputs into the EDLS model to determine activity timing/type and the mechanical "dose" imparted on the musculoskeletal system of crew members and relate this dose to changes in bone homeostasis.

  14. Strategic business planning for internal medicine.

    PubMed

    Ervin, F R

    1996-07-01

    The internal medicine generalist is at market risk with expansion of managed care. The cottage industry of Academic Departments of internal medicine should apply more business tools to the internal medicine business problem. A strength, weakness, opportunity, threat (SWOT) analysis demonstrates high vulnerability to the internal medicine generalist initiative. Recommitment to the professional values of internal medicine and enhanced focus on the master clinician as the competitive core competency of internal medicine will be necessary to retain image and market share.

  15. Enhancing the output current of a CdTe solar cell via a CN-free hydrocarbon luminescent down-shifting fluorophore with intramolecular energy transfer and restricted internal rotation characteristics.

    PubMed

    Li, Yilin; Olsen, Joseph; Dong, Wen-Ji

    2015-04-01

    A CN-free hydrocarbon fluorophore (Perylene-TPE) was synthesized as a new luminescent down-shifting (LDS) material. Its photophysical properties in both the solution state and the solid state were studied. The unity fluorescence quantum yield of Perylene-TPE observed in its solid state is considered to be from the characteristics of intramolecular energy transfer (IET) and restricted internal rotation (RIR). This is supported by the results from theoretical calculations and spectroscopic measurements. For the photovoltaic application of Perylene-TPE, a theoretical modeling study suggests that using the LDS film of Perylene-TPE may increase the output short circuit current density (Jsc) of a CdTe solar cell by 2.95%, enhance the spectral response of a CdTe solar cell at 400 nm by 41%, and shift the incident solar photon distribution from short-wavelength (<500 nm) to long-wavelength (>500 nm). Experimentally, placing a LDS film of Perylene-TPE on a CdTe solar cell can enhance its output Jsc by as high as 3.30 ± 0.31%, which is comparable to the current commercially available LDS material – Y083 (3.28% ± 0.37%). PMID:25679960

  16. Enhancing the output current of a CdTe solar cell via a CN-free hydrocarbon luminescent down-shifting fluorophore with intramolecular energy transfer and restricted internal rotation characteristics.

    PubMed

    Li, Yilin; Olsen, Joseph; Dong, Wen-Ji

    2015-04-01

    A CN-free hydrocarbon fluorophore (Perylene-TPE) was synthesized as a new luminescent down-shifting (LDS) material. Its photophysical properties in both the solution state and the solid state were studied. The unity fluorescence quantum yield of Perylene-TPE observed in its solid state is considered to be from the characteristics of intramolecular energy transfer (IET) and restricted internal rotation (RIR). This is supported by the results from theoretical calculations and spectroscopic measurements. For the photovoltaic application of Perylene-TPE, a theoretical modeling study suggests that using the LDS film of Perylene-TPE may increase the output short circuit current density (Jsc) of a CdTe solar cell by 2.95%, enhance the spectral response of a CdTe solar cell at 400 nm by 41%, and shift the incident solar photon distribution from short-wavelength (<500 nm) to long-wavelength (>500 nm). Experimentally, placing a LDS film of Perylene-TPE on a CdTe solar cell can enhance its output Jsc by as high as 3.30 ± 0.31%, which is comparable to the current commercially available LDS material – Y083 (3.28% ± 0.37%).

  17. 22 CFR 62.28 - International visitors.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... programs are designed to enable the international visitors to better understand American culture and society and contribute to enhanced American knowledge of foreign cultures. The category is for...

  18. International Perspectives.

    ERIC Educational Resources Information Center

    Allen, Kenn; Habermann, Ulla; Chowdhury, Omar Faruque; Guerra, Iraida Manzanilla

    1998-01-01

    Includes "Introduction to International Perspectives" (Allen); "Volunteerism in the Welfare State: The Case of Denmark" (Habermann); "Grassroots Organizing in Bangladesh" (Chowdhury); and "Volunteerism in Latin America" (Guerra). (SK)

  19. Application of Locked Nucleic Acid (LNA) Primer and PCR Clamping by LNA Oligonucleotide to Enhance the Amplification of Internal Transcribed Spacer (ITS) Regions in Investigating the Community Structures of Plant–Associated Fungi

    PubMed Central

    Ikenaga, Makoto; Tabuchi, Masakazu; Kawauchi, Tomohiro; Sakai, Masao

    2016-01-01

    The simultaneous extraction of host plant DNA severely limits investigations of the community structures of plant–associated fungi due to the similar homologies of sequences in primer–annealing positions between fungi and host plants. Although fungal-specific primers have been designed, plant DNA continues to be excessively amplified by PCR, resulting in the underestimation of community structures. In order to overcome this limitation, locked nucleic acid (LNA) primers and PCR clamping by LNA oligonucleotides have been applied to enhance the amplification of fungal internal transcribed spacer (ITS) regions. LNA primers were designed by converting DNA into LNA, which is specific to fungi, at the forward primer side. LNA oligonucleotides, the sequences of which are complementary to the host plants, were designed by overlapping a few bases with the annealing position of the reverse primer. Plant-specific DNA was then converted into LNA at the shifted position from the 3′ end of the primer–binding position. PCR using the LNA technique enhanced the amplification of fungal ITS regions, whereas those of the host plants were more likely to be amplified without the LNA technique. A denaturing gradient gel electrophoresis (DGGE) analysis displayed patterns that reached an acceptable level for investigating the community structures of plant–associated fungi using the LNA technique. The sequences of the bands detected using the LNA technique were mostly affiliated with known isolates. However, some sequences showed low similarities, indicating the potential to identify novel fungi. Thus, the application of the LNA technique is considered effective for widening the scope of community analyses of plant–associated fungi. PMID:27600711

  20. International Curriculums.

    ERIC Educational Resources Information Center

    Neal, Larry L.

    This workshop presentation on international curriculums in the field of parks, recreation, leisure, cultural services, and travel/tourism comments that the literature is replete with articles addressing what the field is about, but not about curriculum issues, models, and structure. It reports an international survey of 12 college educators…

  1. International Health

    MedlinePlus

    ... create refugee populations with immediate and long-term health problems. Some of the major diseases currently affecting ... also an international problem which can affect people's health. Many countries and health organizations are working together ...

  2. International Reports.

    ERIC Educational Resources Information Center

    Valauskas, Edward J.; Stowe, Jennifer L.; Haycock, Ken; Dodd, Frances

    1998-01-01

    Presents three reports: International Federation of Library Associations and Institutions; Special Libraries Association; and Canadian library trends, focusing on information technology and access to information and rights and examining provincial libraries and library education. (PEN)

  3. International Geology

    ERIC Educational Resources Information Center

    Hoover, Linn

    1977-01-01

    Briefly discusses recent international programs in various areas of geology, including land-use problems, coping with geological hazards, and conserving the environment while searching for energy and mineral resources. (MLH)

  4. International Business Research: Coauthorship Patterns and Quality

    ERIC Educational Resources Information Center

    Chan, Kam C; Fung, Hung-Gay; Leung, Wai K.

    2008-01-01

    The authors investigate published international business research in four international business journals over a 10-year period, 1995-2004: (a) patterns of coauthorship across regions, and (b) the relation between coauthorship patterns and the quality of international business (IB) articles. A cross-region coauthorship enhances the quality of an…

  5. Theoretical Foundations for International Service-Learning

    ERIC Educational Resources Information Center

    Crabtree, Robbin D.

    2008-01-01

    International service-learning (ISL) combines academic instruction and community-based service in an international context. Objectives of linking international travel, education, and community service include increasing participants' global awareness, building intercultural understanding, and enhancing civic mindedness and skills. Research on…

  6. Internal shim

    DOEpatents

    Barth, Clyde H.; Blizinski, Theodore W.

    2003-05-13

    An internal shim used to accurately measure spaces in conjunction with a standard small probe has a shim top and a chassis. The internal shim is adjustably fixed within the space to be measured using grippers that emerge from the chassis and which are controlled by an arm pivotably attached to the shim top. A standard small probe passes through the shim along guides on the chassis and measures the distance between the exterior of the chassis and the boundary. By summing the measurements on each side of the chassis and the width of the chassis, the dimension of the space can be determined to within 0.001 inches.

  7. International Reports.

    ERIC Educational Resources Information Center

    Anderson, Nancy D.; And Others

    1994-01-01

    Three reports discuss the International Federation of Library Associations and Institutions; the Frankfurt Book Fair, focusing on electronics; and Canadian library trends, including resource sharing, technology projects, information policy, censorship, services for persons with disabilities, construction projects, and library education and…

  8. International Marketplace.

    ERIC Educational Resources Information Center

    Wells, Donald A.; And Others

    1985-01-01

    This issue begins with a conceptual introduction to economic specialization, exports and imports, and the importance of international trade. Four instructional units follow this introduction, beginning with a preschool and kindergarten unit called "Traders and Travelers," which involves young students in five activities that illustrate our…

  9. Enhancing Workgroup Performance.

    ERIC Educational Resources Information Center

    1998

    This document contains four papers from a symposium on enhancing workgroup performance in human resource development (HRD). "Formation of Cross-Cultural Global Teams: Making Informed Choices on Team Composition" (Robert L. Dilworth) describes how a mixed class of U.S. and international students identified their cultural and learning styles and…

  10. Teaching International Law: Concepts in International Relations

    ERIC Educational Resources Information Center

    Starbird, Caroline; Pettit, Jenny; Singleton, Laurel

    2004-01-01

    This book is designed to introduce students to public international law. Topics covered include international public organizations, such as the United Nations and World Trade Organization, international courts, international human rights law, international trade law, and international environmental law. The goal of each study is to examine how…

  11. Healthcare international.

    PubMed

    Hensley, S; Jaklevic, M C; Rauber, C; Weissenstein, E; Moore, J D; Shinkman, R; Pallarito, K; Katzman, C N; Hallam, K; Morrissey, J

    1998-11-01

    How people are treated when they need medical care depends on where in the world they are. In deciding which tools of the medical trade are used to treat disease and when they're used, location is paramount. A country's social policy, healthcare payment systems and cultural factors bear heavily on the utilization of medical technology. The cover story kicks off the magazine's third international healthcare section. PMID:10186352

  12. Rotary International.

    PubMed

    Young, Janis

    2008-01-01

    Rotary International is the oldest United States service organization and one of the largest volunteer groups in the world. There are hundreds of educational, health, and humanitarian activities, almost all of which are conducted locally in order to ensure that Rotary clubs meet the needs of the communities they serve. Club membership requires regular active participation and offers Rotarians multiple opportunities for involvement. PMID:18551844

  13. International cooperation.

    PubMed

    1999-04-01

    As the most densely populated country in the world, China actively conducts international exchanges and cooperation. It takes every opportunity to publicize its family planning policies and practices during international forums. Moreover, the country's State Family Planning Commission has been collaborating with the United Nations Population Fund in implementing health and family planning programs. This program covers public awareness campaigns, technical services, sex education for the youth, and social marketing. For years, China has also been cooperating with WHO in the area of family planning and reproductive health, and has established partnership with the Japanese Organization for International Cooperation in Family Planning. In addition, the State Family Planning Commission has worked with the Public Media Center of the US as well as with the Rockefeller Foundation and Ford Foundation in introducing "contraceptive methods by informed choice" and "male participation in family planning" in the rural areas of the country. China has also worked closely with many other developing countries on population issues. In October 1998, China collaborated with the Partners in Population and Development for a reporting mission that was attended by journalists from 11 countries.

  14. Moral Enhancement

    PubMed Central

    Douglas, Thomas

    2008-01-01

    Opponents of biomedical enhancement often claim that, even if such enhancement would benefit the enhanced, it would harm others. But this objection looks unpersuasive when the enhancement in question is a moral enhancement — an enhancement that will expectably leave the enhanced person with morally better motives than she had previously. In this article I (1) describe one type of psychological alteration that would plausibly qualify as a moral enhancement, (2) argue that we will, in the medium-term future, probably be able to induce such alterations via biomedical intervention, and (3) defend future engagement in such moral enhancements against possible objections. My aim is to present this kind of moral enhancement as a counter-example to the view that biomedical enhancement is always morally impermissible. PMID:19132138

  15. [Internal migration].

    PubMed

    Borisovna, L

    1991-06-01

    Very few studies have been conducted that truly permit explanation of internal migration and it repercussions on social and economic structure. It is clear however that a profound knowledge of the determinants and consequences of internal migration will be required as a basis for economic policy decisions that advance the goal of improving the level of living of the population. the basic supposition of most studies of the relationship of population and development is that socioeconomic development conditions demographic dynamics. The process of development in Mexico, which can be characterized by great heterogeneity, consequently produces great regional disparities. At the national level various studies have estimated the volume of internal migration in Mexico, but they have usually been limited to interstate migration because the main source of data, the census, is classified by states. But given the great heterogeneity within states in all the elements related to internal migration, it is clear that studies of internal migration within states are also needed. Such studies are almost nonexistent because of their technical difficulty. National level studies show that interstate migration increased significantly between 1940-80. The proportion of Mexicans living outside their states of birth increased by 558% in those years, compared to the 342% increase in the total Mexican population. Although Puebla has a high rate of increase, migration has kept it below Mexico's national growth rate. Migration between Puebla and other states and within Puebla has led to an increasing unevenness of spatial distribution. Between 1970-80, 57 of Puebla's municipios had growth rates above the state average of 2.8%/year, 6 had growth rates equal to the average, and 129 had growth rates that were below the average but not negative. 25 states with negative growth rates that were considered strongly expulsive. In 1980, 51.7% of the population was concentrated in the 57 municipios

  16. OLED devices with internal outcoupling

    DOEpatents

    Liu, Jie Jerry; Sista, Srinivas Prasad; Shi, Xiaolei; Zhao, Ri-An; Chichak, Kelly Scott; Youmans, Jeffrey Michael; Janora, Kevin Henry; Turner, Larry Gene

    2015-03-03

    Optoelectronic devices that have enhanced internal outcoupling are disclosed. The devices include a substrate, an anode, a cathode, an electroluminescent layer, and a hole injecting layer. The hole injecting layer includes inorganic nanoparticles that have a bimodal particle size distribution and which are dispersed in an organic matrix.

  17. Operating internationally

    SciTech Connect

    Seeley, R.S.

    1994-02-01

    When Enron Power Corp. took over a 28 MW power facility at the former US Naval base in Subic Bay, the Philippines, the company was required to employ 139 people to run the plant. This large labor force was necessary not because of the plant's operational needs, but because of local labor practices and unemployment pressures. Independent power companies have become all too familiar with the high cost and complexity of developing projects in emerging international markets. Some of the most significant issues involve taxation, unfamiliar legal systems, changing regulations, and foreign investment restrictions. In addition, questions about currency exchange, national credit worthiness, and political stability add to the difficulty of international development. However, one of the most daunting challenges centers not on development, but on long-term operations and maintenance (O M). A key concern is finding qualified labor. Most developers and O M companies agree that local people should run the plant, with the top person, or persons, thoroughly trained in the developer's company philosophy.

  18. Column internals

    SciTech Connect

    Bravo, J.L.

    1998-02-01

    In the fields of distillation, absorption, stripping and extraction, theory and technology go hand in hand. The thermodynamic principles of phase equilibrium and the concepts of mass transfer and fluid flow are of primary importance in all of these operations. The engineer must understand these phenomena to select equipment effectively. This article discusses the latest in commercial technology in column internals for gas-liquid and liquid-liquid contacting. The principles of operation are explained vis-a-vis the characteristics of the applications in which they are used. The focus is on moderate-to-large columns for refining and chemical applications. Guidelines for selecting the most appropriate type of device are presented, and examples of typical applications are described.

  19. International environmental law and global public health.

    PubMed Central

    Schirnding, Yasmin von; Onzivu, William; Adede, Andronico O.

    2002-01-01

    The environment continues to be a source of ill-health for many people, particularly in developing countries. International environmental law offers a viable strategy for enhancing public health through the promotion of increased awareness of the linkages between health and environment, mobilization of technical and financial resources, strengthening of research and monitoring, enforcement of health-related standards, and promotion of global cooperation. An enhanced capacity to utilize international environmental law could lead to significant worldwide gains in public health. PMID:12571726

  20. International environmental law and global public health.

    PubMed

    Schirnding, Yasmin von; Onzivu, William; Adede, Andronico O

    2002-01-01

    The environment continues to be a source of ill-health for many people, particularly in developing countries. International environmental law offers a viable strategy for enhancing public health through the promotion of increased awareness of the linkages between health and environment, mobilization of technical and financial resources, strengthening of research and monitoring, enforcement of health-related standards, and promotion of global cooperation. An enhanced capacity to utilize international environmental law could lead to significant worldwide gains in public health.

  1. Recent developments in turbine blade internal cooling.

    PubMed

    Han, J C; Dutta, S

    2001-05-01

    This paper focuses on turbine blade internal cooling. Internal cooling is achieved by passing the coolant through several rib-enhanced serpentine passages inside the blade and extracting the heat from the outside of the blades. Both jet impingement and pin-fin-cooling are also used as a method of internal cooling. In the past number of years there has been considerable progress in turbine blade internal cooling research and this paper is limited to reviewing a few selected publications to reflect recent developments in turbine blade internal cooling. PMID:11460626

  2. On the New International Communication Agency.

    ERIC Educational Resources Information Center

    Bray, Charles W., III

    The International Communication Agency (ICA) was created in April 1978 to help facilitate relations between the United States and other nations. Its main function is to enrich the supplies of information among peoples in order to enhance understanding. An examination of the international context in which the ICA will operate reveals the urgent…

  3. International Education for Wisconsin.

    ERIC Educational Resources Information Center

    Moebius, Barbara

    1990-01-01

    Describes an international trade education program offered by Waukesha (WI) County Technical College. The program includes international business principles, international marketing, cultural awareness, business Spanish, international documentation, transportation, and finance. (JOW)

  4. International cooperation in water resources

    USGS Publications Warehouse

    Jones, J.R.; Beall, R.M.; Giusti, E.V.

    1979-01-01

    Advancements in hydrology proceeded slowly until the late 1800's when new ventures created a surge of interest and accomplishment. Progress waned again until the middle 20th century when an International Hydrological Decade was conceived, eventually receiving wide multinational support from governmental agencies and nongovernmental institutions. Organized by UNESCO, the Decade program was launched January 1, 1965. Participation included 107 nations, six United Nations agencies, and more than a dozen international scientific organizations. The initial program emphasized scientific research, and international cooperation; the second half of the Decade, emphasized technical assistance and technology transfer, largerly through education, training and demonstration. The success of the Decade led to the establishment of the International Hydrological Program, again under the aegis of UNESCO, to continue the work of the Decade indefinitely. The five major program activities, now involving about 90 countries and several international organizations, include: the scientific program, the promotion of education and training, the enhancement of information exchange, support of technical assistance, and the enlargement of regional cooperation. A significant amount of activity related to hydrological data networks and forecasting is carried on in an Operational Hydrology Programme by the WMO, chiefly through its Commission for Hydrology. Other international governmental organizations with a strong interest in water include the UN, the UN Development Programme, the FAO, the WHO, the International Atomic Energy Agency, the UN Environment Programme, the International Standardization Organization, and developmental institutions such as the World Bank. The specialized interests of researchers outside of the governmental structure, are met through association in various scientific and technical organizations which are world wide in scope and membership. Notwithstanding a sometimes

  5. Hospitals' Internal Accountability

    PubMed Central

    Kraetschmer, Nancy; Jass, Janak; Woodman, Cheryl; Koo, Irene; Kromm, Seija K.; Deber, Raisa B.

    2014-01-01

    This study aimed to enhance understanding of the dimensions of accountability captured and not captured in acute care hospitals in Ontario, Canada. Based on an Ontario-wide survey and follow-up interviews with three acute care hospitals in the Greater Toronto Area, we found that the two dominant dimensions of hospital accountability being reported are financial and quality performance. These two dimensions drove both internal and external reporting. Hospitals' internal reports typically included performance measures that were required or mandated in external reports. Although respondents saw reporting as a valuable mechanism for hospitals and the health system to monitor and track progress against desired outcomes, multiple challenges with current reporting requirements were communicated, including the following: 58% of survey respondents indicated that performance-reporting resources were insufficient; manual data capture and performance reporting were prevalent, with the majority of hospitals lacking sophisticated tools or technology to effectively capture, analyze and report performance data; hospitals tended to focus on those processes and outcomes with high measurability; and 53% of respondents indicated that valuable cross-system accountability, performance measures or both were not captured by current reporting requirements. PMID:25305387

  6. Hospitals' internal accountability.

    PubMed

    Kraetschmer, Nancy; Jass, Janak; Woodman, Cheryl; Koo, Irene; Kromm, Seija K; Deber, Raisa B

    2014-09-01

    This study aimed to enhance understanding of the dimensions of accountability captured and not captured in acute care hospitals in Ontario, Canada. Based on an Ontario-wide survey and follow-up interviews with three acute care hospitals in the Greater Toronto Area, we found that the two dominant dimensions of hospital accountability being reported are financial and quality performance. These two dimensions drove both internal and external reporting. Hospitals' internal reports typically included performance measures that were required or mandated in external reports. Although respondents saw reporting as a valuable mechanism for hospitals and the health system to monitor and track progress against desired outcomes, multiple challenges with current reporting requirements were communicated, including the following: 58% of survey respondents indicated that performance-reporting resources were insufficient; manual data capture and performance reporting were prevalent, with the majority of hospitals lacking sophisticated tools or technology to effectively capture, analyze and report performance data; hospitals tended to focus on those processes and outcomes with high measurability; and 53% of respondents indicated that valuable cross-system accountability, performance measures or both were not captured by current reporting requirements. PMID:25305387

  7. Community College Internal Auditors: Internal Audit Guidebook.

    ERIC Educational Resources Information Center

    Jones, Ronna; And Others

    This guidebook includes information compiled by the "Audit Manual" committee of Community College Internal Auditors (CCIA) from several California community college districts regarding their internal auditing practices. The first section of the guidebook discusses the purpose of internal audits, indicating that audits assist members of the…

  8. Biocatalyst Enhancement

    EPA Science Inventory

    The increasing availability of enzyme collections has assisted attempts by pharmaceutical producers to adopt green chemistry approaches to manufacturing. A joint effort between an enzyme producer and a pharmaceutical manufacturer has been enhanced over the past three years by ena...

  9. International Physical Protection Advisory Service

    SciTech Connect

    Soo Hoo, M.S.; Ek, D.; Hageman, A.; Jenkin, T.; Price, C.; Weiss, B.

    1998-08-01

    Since its inception in 1996, the purpose of the International Physical Protection Advisory Service (IPPAS) has been to provide advice and assistance to International Atomic Energy Agency (IAEA) Member States on strengthening and enhancing the effectiveness of their state system of physical protection of nuclear materials and facilities. Since the protection of nuclear materials and facilities is a Member State`s responsibility, participation within the IPPAS program is voluntary. At the request of a Member State, the IAEA forms a multinational IPPAS team consisting of physical protection specialists. These specialists have broad experience in physical protection system design, implementation, and regulatory oversight. The exact make-up of the team depends upon the needs of the requesting state. IPPAS missions to participating states strive to compare the domestic procedures and practices of the state against international physical protection guidelines (IAEA Information Circular 225) and internationally accepted practice. The missions utilize a top to bottom approach and begin by reviewing the legal and regulatory structure and conclude with reviews of the implementation of the state regulations and international guidelines at individual facilities. IPPAS findings are treated as IAEA Safeguards Confidential Information. To date, IPPAS missions have been concluded in Slovenia, Bulgaria, Romania, Hungary, and Poland.

  10. [Evaluation of the right internal iliac artery which is anastomosed to transplant renal artery using non-contrast enhanced MR angiography with electrocardiography-gated and 3D True SSFP time-spatial labeling inversion pulse sequence].

    PubMed

    Yoshida, Ayako; Shiratori, Yoko; Suzuki, Makoto; Ozasa, Masaya; Takeyama, Mamoru; Eshima, Mitsuhiro; Shinohara, Maiko; Yamamoto, Takao; Tajima, Tsuyoshi

    2015-05-01

    To evaluate whether electrocardiography-gated is useful in non-contrast-enhanced MRA with time-spatial labeling inversion pulse (Time-SLIP) in renal transplantation patients compared with respiration-triggered free-breathing. Simulation-based analyses of black blood time interval (BBTI) values for spatial selective inversion-recovery pulse and electrocardiography rates were performed, and confirmed on human subjects using a three-dimensional (3D) coherent steady-state free precession (SSFP) sequence on a 1.5 tesla Toshiba MRI scanner. Signal acquisition interval and BBTI values in which signal of a water tissue becomes the null point showed a strong correlation, and successfully suppressed signals from the background and provided better contrast between the arteries and the background. Because electrocardiography-gated non-contrast MRA does not depend on the respiration interval, providing a contrast stable, it was suggested to be an effective screening tool for evaluation of pelvic arteries.

  11. Enhancements to PVM's BEOLIN architecture

    NASA Technical Reports Server (NTRS)

    Springer, Paul L.

    2005-01-01

    .4.3 of PVM had previously been enhanced by the addition of a new architecture, BEOLIN, which allowed a PVM user to abstract a Beowulf class computer with a private network to appear as a single system, visible to the outside world, which could spawn tasks on different internal nodes.

  12. The internal dynamics of international migration systems.

    PubMed

    Waldorf, B

    1996-04-01

    "In this paper I provide a conceptualization of international migration networks, which can be used to identify and integrate the internal components of migration systems, and formalize the relationships in an analytic model of the internal network dynamic. With the use of the operationalized model, and microlevel and macrolevel data for guestworkers in Germany during the period 1970 to 1989, we can empirically test the relative influence of internal network variables versus external forces on the attraction of immigrants over time. The empirical results suggest that--as the system matures--network variables have an increasing impact on the attraction of immigrants, while the impact of economic factors declines. The research is concluded with a series of simulations that further highlight the internal dynamic of international migration systems."

  13. Theme: International Development.

    ERIC Educational Resources Information Center

    Martin, Robert A.; And Others

    1989-01-01

    Consists of seven articles focusing on international agricultural education. Topics discussed include (1) international curriculum development, (2) programs for rural youth, (3) experiential training in international agriculture, (4) university/high school global exchange, (5) international development, and (5) the Association of International…

  14. Enhancing Opportunities.

    ERIC Educational Resources Information Center

    Meyers, Michelle J.

    1994-01-01

    Hispanics can enhance their professional career by finding jobs with corporations that offer to pay for graduate tuition. This opportunity has positively influenced the careers of many Hispanics and has proven advantageous for corporations as well by increasing the knowledge and skills of their employees. (LP)

  15. 7 CFR 371.8 - International Services.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Organization of the United Nations, with regard to APHIS activities in foreign countries. (5) Developing and... their effect on the agriculture industry. (6) Developing and directing programs to enhance the trade in... 7 Agriculture 5 2014-01-01 2014-01-01 false International Services. 371.8 Section...

  16. 7 CFR 371.8 - International Services.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Organization of the United Nations, with regard to APHIS activities in foreign countries. (5) Developing and... their effect on the agriculture industry. (6) Developing and directing programs to enhance the trade in... 7 Agriculture 5 2013-01-01 2013-01-01 false International Services. 371.8 Section...

  17. 7 CFR 371.8 - International Services.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Organization of the United Nations, with regard to APHIS activities in foreign countries. (5) Developing and... their effect on the agriculture industry. (6) Developing and directing programs to enhance the trade in... 7 Agriculture 5 2012-01-01 2012-01-01 false International Services. 371.8 Section...

  18. International Volunteering: Employability, Leadership and More

    ERIC Educational Resources Information Center

    Rothwell, Andrew; Charleston, Brandon

    2013-01-01

    Purpose: The purpose of this paper is to investigate the experiences of individuals in transition between education and work during international volunteering expeditions. While it was expected that outcomes might include employability enhancement and skill development, the authors aimed to clarify what the main factors were, examine employability…

  19. Simulating History to Understand International Politics

    ERIC Educational Resources Information Center

    Weir, Kimberly; Baranowski, Michael

    2011-01-01

    To understand world politics, one must appreciate the context in which international systems develop and operate. Pedagogy studies demonstrate that the more active students are in their learning, the more they learn. As such, using computer simulations can complement and enhance classroom instruction. CIVILIZATION is a computer simulation game…

  20. International Development Program 2006 Impact Review

    ERIC Educational Resources Information Center

    American Institutes for Research, 2006

    2006-01-01

    The American Institutes for Research's (AID's) International Development Program (IDP) seeks to enhance the capacity of developing countries to improve the quality of life through education and social development. Its work is based on a strong belief in the transformative power of education--that by providing children the opportunity to learn and…

  1. Enhanced radiation resistant fiber optics

    DOEpatents

    Lyons, Peter B.; Looney, Larry D.

    1993-01-01

    A process for producing an optical fiber having enhanced radiation resitance is provided, the process including maintaining an optical fiber within a hydrogen-containing atmosphere for sufficient time to yield a hydrogen-permeated optical fiber having an elevated internal hydrogen concentration, and irradiating the hydrogen-permeated optical fiber at a time while the optical fiber has an elevated internal hydrogen concentration with a source of ionizing radiation. The radiation source is typically a cobalt-60 source and the fiber is pre-irradiated with a dose level up to about 1000 kilorads of radiation.

  2. Enhanced radiation resistant fiber optics

    DOEpatents

    Lyons, P.B.; Looney, L.D.

    1993-11-30

    A process for producing an optical fiber having enhanced radiation resistance is provided, the process including maintaining an optical fiber within a hydrogen-containing atmosphere for sufficient time to yield a hydrogen-permeated optical fiber having an elevated internal hydrogen concentration, and irradiating the hydrogen-permeated optical fiber at a time while the optical fiber has an elevated internal hydrogen concentration with a source of ionizing radiation. The radiation source is typically a cobalt-60 source and the fiber is pre-irradiated with a dose level up to about 1000 kilorads of radiation. 4 figures.

  3. Improving Internal Communication.

    ERIC Educational Resources Information Center

    Bonus, Thaddeus, Ed.

    Guidelines for developing the internal communications of colleges and universities, researching internal communication needs, and increasing information flow through traditional and nontraditional media are provided in 11 articles. Titles and authors include the following: "Work for an Open Internal Communication Policy" (Thaddeus Bonus); "Five…

  4. Fishbone and internal kinks

    SciTech Connect

    Strauss, H.; Park, W.; Monticello, D.; Izzo, R.; White, R.; McGuire, K.; Manickam, J.; Goldston, R.

    1983-07-01

    The internal-kink mode, combined with neutral-beam heating and beam losses, appears to be responsible for the fishbone soft x-ray oscillations in PDX. Nonlinear simulations of both ideal and resistive kinks are presented and shown to be consistent with experimental observations. The internal kink may also be important in low-beta internal disruptions.

  5. Children and International Education.

    ERIC Educational Resources Information Center

    Association for Childhood Education International, Washington, DC.

    Developed as a plan of action in international education for teachers and students, this portfolio emphasizes the importance of developing a knowledge and appreciation of others, the acquaintance of resources for planning experiences of international understanding, and the participation in international programs to encourage an understanding of…

  6. IgG4 Immunostaining and Its Implications in Orbital Inflammatory Disease

    PubMed Central

    Wong, Amanda J.; Planck, Stephen R.; Choi, Dongseok; Harrington, Christina A.; Troxell, Megan L.; Houghton, Donald C.; Stauffer, Patrick; Wilson, David J.; Grossniklaus, Hans E.; Dailey, Roger A.; Ng, John D.; Steele, Eric A.; Harris, Gerald J.; Czyz, Craig; Foster, Jill A.; White, Valerie A.; Dolman, Peter J.; Kazim, Michael; Patel, Payal J.; Edward, Deepak P.; Katan, Hind al; Hussain, Hailah al; Selva, Dinesh; Yeatts, R. Patrick; Korn, Bobby S.; Kikkawa, Don O.; Rosenbaum, James T.

    2014-01-01

    Objective IgG4-related disease is an emerging clinical entity which frequently involves tissue within the orbit. In order to appreciate the implications of IgG4 immunostaining, we analyzed gene expression and the prevalence of IgG4- immunostaining among subjects with orbital inflammatory diseases. Methods We organized an international consortium to collect orbital biopsies from 108 subjects including 22 with no known orbital disease, 42 with nonspecific orbital inflammatory disease (NSOI), 26 with thyroid eye disease (TED), 12 with sarcoidosis, and 6 with granulomatosis with polyangiitis (GPA). Lacrimal gland and orbital adipose tissue biopsies were immunostained for IgG4 or IgG secreting plasma cells. RNA transcripts were quantified by Affymetrix arrays. Results None of the healthy controls or subjects with TED had substantial IgG4 staining. Among the 63 others, the prevalence of significant IgG4-immunostaining ranged from 11 to 39% depending on the definition for significant. IgG4 staining was detectable in the majority of tissues from subjects with GPA and less commonly in tissue from subjects with sarcoidosis or NSOI. The detection of IgG4+ cells correlated with inflammation in the lacrimal gland based on histology. IgG4 staining tissue expressed an increase in transcripts associated with inflammation, especially B cell-related genes. Functional annotation analysis confirmed this. Conclusion IgG4+ plasma cells are common in orbital tissue from patients with sarcoidosis, GPA, or NSOI. Even using the low threshold of 10 IgG4+ cells/high powered field, IgG4 staining correlates with increased inflammation in the lacrimal gland based on histology and gene expression. PMID:25303270

  7. Pathway from Vocational Education and Associate Degree to Higher Education: Chinese International Students in Australia

    ERIC Educational Resources Information Center

    Cao, Ling; Tran, Ly Thi

    2015-01-01

    Understanding factors influencing international students' decision to engage in international education is essential for education providers to better cater for students' educational expectations and enhance their attractiveness to international students. Whilst there has been extensive research on the reasons why international students undertake…

  8. Enhancing bioremediation

    SciTech Connect

    Koenigsberg, S.

    1997-02-01

    Oxygen is often the limiting factor in aerobic bioremediation. Without adequate oxygen, contaminant degradation will either cease or proceed by highly inefficient anaerobic processes. Researchers at Regenesis Bioremediation Products recently develope a technology to combat this problem, Oxygen Release Compound (ORC) a unique formulation of magnesium peroxide release oxygen slowly when hydrated. ORC is idea for supporting bioremediation of underground storage tank releases. ORC treatment represents a low intensity approach to remediation - simple, passive, low-cost, long term enhancement of a natural attenuation. 1 fig.

  9. Taxonomy of potential international safeguards regimes

    SciTech Connect

    Lemley, J.R.; Allentuck, J.

    1994-08-01

    Since the International Atomic Energy Agency`s (IAEA) search for the components of Iraq`s nuclear weapons program under the auspices of the United Nations Security Council, a consensus for enhancing, strengthening or expanding the scope of international safeguards has developed. Some of the enhanced safeguards concepts which have been suggested include the following: short-notice, challenge, and random inspections; effluent monitoring in onsite, near site, and fly-by modes; local and wide-area environmental monitoring; and utilization of data from space-platform sensors. Potential safeguards regimes can be classified according to the functional and technical criteria which would be necessary for implementation of various enhanced safeguards concepts. While the nature of the regime which will emerge cannot be predicted, the classification of possible regimes according to major characteristics can be useful for identifying functional criteria and implementation challenges, focusing development efforts on the functional criteria, and planning for efficient use of safeguards resources. Precedents established in previously negotiated treaties -- the Chemical Weapons Convention, the Treaty on Conventional Forces in Europe, START, and Open Skies -- are examined with regard to enhancement of the international safeguards regime for nuclear and other weapons of mass destruction. Bilateral, multilateral and regional integration of enhanced safeguards elements is considered.

  10. Neurology and international organizations.

    PubMed

    Mateen, Farrah J

    2013-07-23

    A growing number of international stakeholders are engaged with neurologic diseases. This article provides a brief overview of important international stakeholders in the practice of neurology, including global disease-specific programs, United Nations agencies, governmental agencies with international influence, nongovernmental organizations, international professional organizations, large private donors, private-public partnerships, commercial interests, armed forces, and universities and colleges. The continued engagement of neurologists is essential for the growing number of international organizations that can and should incorporate neurologic disease into their global agendas.

  11. EDITORIAL: Enhancing nanolithography Enhancing nanolithography

    NASA Astrophysics Data System (ADS)

    Demming, Anna

    2012-01-01

    Lithography was invented in late 18th century Bavaria by an ambitious young playwright named Alois Senefelder. Senefelder experimented with stone, wax, water and ink in the hope of finding a way of reproducing text so that he might financially gain from a wider distribution of his already successful scripts. His discovery not only facilitated the profitability of his plays, but also provided the world with an affordable printing press that would ultimately democratize the dissemination of art, knowledge and literature. Since Senefelder, experiments in lithography have continued with a range of innovations including the use of electron beams and UV that allow increasingly higher-resolution features [1, 2]. Applications for this have now breached the limits of paper printing into the realms of semiconductor and microelectronic mechanical systems technology. In this issue, researchers demonstrate a technique for fabricating periodic features in poly(3,4-ethylene dioxythiophene)-poly(styrenesulfonate) (PEDOT-PSS) [3]. Their method combines field enhancements from silica nanospheres with laser-interference lithography to provide a means of patterning a polymer that has the potential to open the market of low-end, high-volume microelectronics. Laser-interference lithography has already been used successfully in patterning. Researchers in Korea used laser-interference lithography to generate stamps for imprinting a two-dimensional photonic crystal structure into green light emitting diodes (LEDs) [4]. The imprinted patterns comprised depressions 100 nm deep and 180 nm wide with a periodicity of 295 nm. In comparison with unpatterned LEDs, the intensity of photoluminescence was enhanced by a factor of seven in the LEDs that had the photonic crystal structures imprinted in them. The potential of exploiting field enhancements around nanostructures for new technologies has also attracted a great deal of attention. Researchers in the USA and Australia have used the field

  12. CARE 3, Version 4 enhancements

    NASA Technical Reports Server (NTRS)

    Bryant, L. A.; Stiffler, J. J.

    1985-01-01

    The enhancements and error corrections to CARE III Version 4 are listed. All changes to Version 4 with the exception of the internal redundancy model were implemented in Version 5. Version 4 is the first public release version for execution on the CDC Cyber 170 series computers. Version 5 is the second release version and it is written in ANSI standard FORTRAN 77 for execution on the DEC VAX 11/700 series computers and many others.

  13. deKieffer International Fellowship Award Receives Endowment

    ERIC Educational Resources Information Center

    Cornell, Dick

    2009-01-01

    The AECT International Division held its 22nd annual dinner and auction on November 6, 2008 in Orlando, Florida. During this event it was announced that the "ect" Foundation is now the recipient of a $10,000 endowment intended to further enhance the annual monetary award of the Robert E. deKieffer International Fellowship Award. The gift was made…

  14. Using Web-Based Foreign Advertisements in International Marketing Classes

    ERIC Educational Resources Information Center

    Ryan, Jason

    2011-01-01

    The author examines the use of the Web-based foreign advertisements for enhancing the international awareness of undergraduate marketing students. An analysis compares the adaptation of advertisements for identical products to the cultural perceptions and values of consumers in different countries. In a sample of 110 international marketing…

  15. The World in Bexley...Instructional Units Incorporating International Education.

    ERIC Educational Resources Information Center

    Bexley City School District, OH.

    This publication contains sample instructional units that were developed by staff members of the Bexley, Ohio City School District at an international education institute. The 33 units began with the regular curriculum of the district, and sought to integrate aspects of international education in such a way as to enhance the learning experience.…

  16. International School Psychology: Psychology's Worldwide Portal to Children and Youth

    ERIC Educational Resources Information Center

    Oakland, Thomas D.

    2003-01-01

    International school psychology is discussed in reference to scholarly and professional development within psychology, the emergence of an international association of school psychology, its efforts to promote school psychology, prevailing characteristics of school psychologists, and additional efforts needed to further enhance its development.…

  17. International Cooperation and Competition in Civilian Space Activities.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Office of Technology Assessment.

    This report assesses the state of international competition in civilian space activities, explores United States civilian objectives in space, and suggests alternative options for enhancing the overall U.S. position in space technologies. It also investigated past, present, and projected international cooperative arrangements for space activities…

  18. Improving International Relations: Is There a Role for Community Colleges?

    ERIC Educational Resources Information Center

    Diaz, Carlos F.; And Others

    1985-01-01

    Presents essays by five prominent public servants/educators discussing the role of community colleges in enhancing international/intercultural understanding and global cooperation. Authors are Carlos Diaz, political science instructor; Gerhard Hess, international studies director; Daniel Inouye, U.S. Senator; Stephen Nicholson, college president;…

  19. Enhancing International Business Education through Restructuring Business Schools

    ERIC Educational Resources Information Center

    Jain, Subhash C.

    2009-01-01

    Many scholars have found fault with the way business schools conduct their business (Pfeffer & Fong, 2002; Mintzberg, 2004; Bennis & O'Toole, 2005; Andrews & Tyson, 2006). This article argues that B-schools should overhaul their curriculum and encourage faculty to undertake research which is useful for practitioners. Suggestions are made for…

  20. Internal auditing in hospitals.

    PubMed

    Edwards, Don; Kusel, Jim; Oxner, Tom

    2003-01-01

    The authors analyzed two national surveys to determine answers for two basic questions: How do the roles of internal auditors compare with those of their counterparts in other industries and to what extent over the past 6 years have the activities of internal auditors changed? Internal auditors in hospitals allocate their time primarily to financial/compliance and operational types of audits, as do their counterparts. The current trend is toward more operational types of audits. In the early years of employment, staff turnover in hospitals is significantly higher than in all combined industries, often leading to internal auditors' filling other positions in the organization. Hospital staff salaries are higher than are salaries in other industries combined. Staff composition continues to reflect the growing presence of women in the field. The majority of internal auditing directors believe that their salaries are fair, would recommend internal auditing as a career position, and are treated as valued consultants in the organization.

  1. International Heliophysical Year

    NASA Technical Reports Server (NTRS)

    Davila, J. M.; Harrison, R.; Poland, A.; St.Cyr, O. C.; Thompson, B. J.; Rabin, Douglas (Technical Monitor)

    2002-01-01

    In 1957 a program of international research, inspired by the International Polar Years of 1882-83 and 1932-33, was organized as the International Geophysical Year (IGY) to study global phenomena of the Earth and geospace. The IGY involved about 60,000 scientists from 66 nations, working at thousands of stations, from pole to pole to obtain simultaneous, global observations on Earth and in space. There had never been anything like it before. The fiftieth anniversary of the International Geophysical Year will occur in 2007. We propose to organize an international program of scientific collaboration for this time period called the International Heliophysical Year (IHY). Like it predecessors, the IHY will focus on fundamental global questions of Earth science.

  2. The International Heliophysical Year

    NASA Technical Reports Server (NTRS)

    Thompson, Barbara J.

    2007-01-01

    In 1957 a program of international research, inspired by the International Polar Years of 1882 and 1932, was organized as the International Geophysical Year (IGY) to study global phenomena of the Earth and geospace. Fifty years later, the world s space science community will again come together for international programs of scientific collaboration: the International Heliophysical Year (IHY), the Electronic Geophysical Year (eGY), and the International Polar Year (IPY) 2007. This time, research will extend out into the Heliosphere to focus on solar-terrestrial-planetary interactions. The ambitious plans for the IHY, eGY and IPY incorporate the activities of scientists in 191 nations, as well as the IGY Gold Historical Preservation initiative, plus a series of coordinated campaigns involving more than 100 instruments and models, education and public outreach programs, a developing nations instrument development program, and opportunities for supported research worldwide. The presentation will focus on the efforts and operations which will make these activities possible.

  3. The International Laser Ranging Service

    NASA Astrophysics Data System (ADS)

    Pearlman, M. R.; Degnan, J. J.; Bosworth, J. M.

    2002-07-01

    The International Laser Ranging Service (ILRS) was established in September 1998 to support programs in geodetic, geophysical, and lunar research activities and to provide the International Earth Rotation Service (IERS) with products important to the maintenance of an accurate International Terrestrial Reference Frame (ITRF). Now in operation for nearly two years, the ILRS develops (1) the standards and specifications necessary for product consistency, and (2) the priorities and tracking strategies required to maximize network efficiency. The Service collects, merges, analyzes, archives and distributes satellite and lunar laser ranging data to satisfy a variety of scientific, engineering, and operational needs and encourages the application of new technologies to enhance the quality, quantity, and cost effectiveness of its data products. The ILRS works with (1) new satellite missions in the design and building of retroreflector targets to maximize data quality and quantity, and (2) science programs to optimize scientific data yield. The ILRS is organized into permanent components: (1) a Governing Board, (2) a Central Bureau, (3) Tracking Stations and Subnetworks, (4) Operations Centers, (5) Global and Regional Data Centers, and (6) Analysis, Lunar Analysis, and Associate Analysis Centers. The Governing Board, with broad representation from the international Satellite Laser Ranging (SLR) and Lunar Laser Ranging (LLR) community, provides overall guidance and defines service policies, while the Central Bureau oversees and coordinates the daily service activities, maintains scientific and technological data bases, and facilitates communications. Active Working Groups in (1) Missions, (2) Networks and Engineering, (3) Data Formats and Procedures, (4) Analysis, and (5) Signal Processing provide key operational and technical expertise to better exploit current capabilities and to challenge the ILRS participants to keep pace with evolving user needs. The ILRS currently

  4. International safeguards data authentication

    SciTech Connect

    Melton, R.B.; Smith, C.E.; DeLand, S.M.; Manatt, D.R.

    1996-07-01

    The International Safeguards community is becoming increasingly reliant on information stored in electronic form. In international monitoring and related activities it must be possible to verify and maintain the integrity of this electronic information. This paper discusses the use of data authentication technology to assist in accomplishing this task. The paper provides background information, identifies the relevance to international safeguards, discusses issues related to export controls, algorithm patents, key management and the use of commercial vs. custom software.

  5. International environmental policy

    SciTech Connect

    Caldwell, L.K.

    1990-01-01

    This report presents a survey of the global international movement for protection of the human environment. It describes the expanding dimensions of international environmental policy, clarifies that policy's present status, and provides a record of events of continuing historical significance. The author calls attention to the need for international agreements and proposals for such vital global environmental issues as climate change, disintegration of the stratospheric ozone layer, and long-range trans-boundary air pollution.

  6. The International Space University

    NASA Astrophysics Data System (ADS)

    Elaerts, Roger; Peeters, Walter

    2006-05-01

    The International Space University (ISU) offers, with the support of the world space community and within an international and intercultural environment, interdisciplinary post-graduate programmes in space studies. These graduate programmes prepare professionals from all sectors to meet the challenges of international space cooperation and the restructuring of the space sector. Although it was created as recently as 1987, the ISU is remarkably successful: by 2005 it had around 2400 alumni, forming a strong network in the space community.

  7. Ethics of international collaboration

    PubMed Central

    Mandal, Jharna; Dinoop, KP; Parija, Subhash Chandra

    2015-01-01

    Education and research together are vital components of academic institutions and globalization has improved health care education and research in numerous ways, one of which is multinational/transnational research/international collaboration. Usually academic institutions of high-income countries and institutions in low-income countries participate in collaboration. These collaborative research are guided by international ethics codes proposed by the international ethics committee to avoid stringent follow/unethical practices. PMID:25709946

  8. Expanding the role of internal facility assessments

    SciTech Connect

    Kolpa, R.L.; Levenson, J.B.; Weaver, M.A.

    1996-05-01

    The US Air Force (USAF) Environmental Compliance Assessment and Management Program (ECAMP) is an effective and comprehensive system to evaluate environmental compliance at individual USAF installations. The ECAMP assessment is typically performed by a team of experts from the installation`s Major Command (MAJCOM) Headquarters, and is often augmented with technical contractor support. As directed by Air Force policy, an external ECAMP assessment is required at a minimum of every three years for each installation. In the intervening years, each installation is required to perform an internal ECAMP assessment, with its own personnel and resources. Even though team composition differs, the internal and external ECAMP assessments are likely to be very similar in scope, objectives, and deliverables. For over nine years, Argonne National Laboratory (ANL) has supported several Air Force MAJCOMs in performing their external ECAMP assessments. More recently, ANL has also had the opportunity to provide technical support and training at individual installations during their preparation and conduct of internal ECAMP assessments. From that experience, the authors have learned that the quality and value of the internal assessment is enhanced by making it a vehicle for training, planning, and interaction among organizations. Various strategies and techniques have been successfully employed to derive maximum benefit and insight from the internal assessment process. Experiences that involve expanding the scope and objectives of internal assessments to meet specific goals are presented. The expansion of scope and objectives include preassessment training, planning, and evaluator interactions as part of the overall internal assessment process.

  9. International Comparisions Database

    National Institute of Standards and Technology Data Gateway

    International Comparisions Database (Web, free access)   The International Comparisons Database (ICDB) serves the U.S. and the Inter-American System of Metrology (SIM) with information based on Appendices B (International Comparisons), C (Calibration and Measurement Capabilities) and D (List of Participating Countries) of the Comit� International des Poids et Mesures (CIPM) Mutual Recognition Arrangement (MRA). The official source of the data is The BIPM key comparison database. The ICDB provides access to results of comparisons of measurements and standards organized by the consultative committees of the CIPM and the Regional Metrology Organizations.

  10. EM International. Volume 1

    SciTech Connect

    Not Available

    1993-07-01

    It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

  11. International migration, international relations and foreign policy.

    PubMed

    Mitchell, C

    1989-01-01

    Recent literature on migration, international relations, and foreign policy is reviewed in this article, stressing applications of global systems paradigms, studies of state entry and exit rules, and anatomies of domestic policy-setting processes on migration. After a concise assessment of the contemporary theory of global political economy, the paper argues for seeking mid-range generalizations on the international relations of migration. It also suggests that analysis begin with the policy-setting processes of the state. Especially through the use of comparative perspectives available from domestic policy making studies and from the field of international comparative public policy, this approach offers the opportunity to fix empirically the political roles of transnational social forces, which often present themselves as participants in domestic policy contests. Promising future directions in the study of state-to-state relations are also evaluated, with the anticipation that verifying regional or other intermediate patterns of world migration politics may contribute to more general theories of international political economy.

  12. Delaware County Community College Business and International Education Program.

    ERIC Educational Resources Information Center

    Delaware County Community Coll., Media, PA.

    In 1987, Delaware County Community College (DCCC) initiated the Delaware Valley Trade Enhancement Project, comprising a number of activities to promote the involvement of local firms in international trade. One of the first activities of the Delaware Valley Trade Enhancement project was a survey of over 6,000 small and medium-sized businesses in…

  13. On the argument that enhancement is "cheating".

    PubMed

    Schermer, M

    2008-02-01

    One frequently used argument in the discussion on human enhancement is that enhancement is a form of cheating. This argument is well-known in relation to doping in sports, but recently it has also been used with regard to cognitive enhancement in the context of education and exams. This paper analyses the enhancement-is-cheating argument by comparing sports and education, and by evaluating how the argument can be interpreted in both contexts. If cheating is understood as breaking the rules in order to gain an unfair advantage over others, it can be argued that some enhancements are a form of cheating. This problem of cheating is, however, relatively easy to remedy by either changing the rules, or by instituting controls and sanctions. This does not, therefore, constitute a categorical objection to enhancement. A further analysis of the intuitions behind the enhancement-is-cheating argument, however, shows that if sports and education are understood as "practices", with their own internal goods and standards of excellence, some potential problems of enhancement can be articulated. These concern the internal goods and standards of excellence that are characteristic of specific practices. Seen from this perspective, the important question is how enhancement technologies might be embedded in specific practices--or how they might corrode them.

  14. International Cooperation at NASA

    NASA Astrophysics Data System (ADS)

    Tawney, Timothy; Feldstein, Karen

    International cooperation is a cornerstone principle of NASA’s activities, especially within the activities of the Science Mission Directorate. Nearly two thirds of the flight missions in which NASA leads or participates involve international cooperation. Numerous ground based activities also rely on international cooperation, whether because of unique expertise, unique geography, or the need for a global response. Going forward, in an era of tighter budgets and a more integrated global perspective, NASA and the rest of the space agencies around the world will be forced to work more closely together, in a broader array of activities than ever before, in order to be able to afford to push the boundaries of space exploration. The goal of this presentation is to provide an overview of NASA’s current international science cooperative activities. It will include a discussion of why NASA conducts international cooperation and look at the mechanisms through which international cooperation can occur at NASA, including peer-to-peer development of relationships. It will also discuss some of the limiting factors of international cooperation, such as export control, and ways in which to manage those constraints. Finally, the presentation would look at some of the present examples where NASA is working to increase international cooperation and improve coordination. Case studies will be used to demonstrate these mechanisms and concepts. For example, NASA continues to participate in international coordination groups such as the International Mars Exploration Working Group (IMEWG) and International Space Exploration Coordination Group (ISECG), but is expanding into new areas as well. NASA is one of the leaders in expanding and improving international coordination in the area of Near-Earth Object detection, characterization, and mitigation. Having participated in the first meetings of such groups as the International Asteroid Warning Network (IAWN) and Space Missions Planning

  15. The international lithosphere program

    NASA Astrophysics Data System (ADS)

    Flinn, Edward A.

    The International Lithosphere Program is a new international interdisciplinary research program in the solid earth sciences that has been established by the International Council of Scientific Unions (ICSU) at the joint request of the International Union of Geodesy and Geophysics (IUGG) and the International Union of Geological Sciences (IUGS). Its goal is a better understanding of the development of the earth, particularly those aspects upon which human society depends for its well-being.The International Lithosphere Program (ILP) is a natural sequel to a series of international cooperative projects in the geosciences that began with the International Geophysical Year in 1957-58 and continued with the Upper Mantle Project in the 1960's and the International Geodynamics Project (IGP) in the 1970's. In 1977, IUGG and IUGS established an inter-union task group to consider the possibility of a successor to the IGP for the 1980's. The task group, under cochairmen Carl Kisslinger (Cooperative Institute for Research in Environmental Sciences, University of Colorado), foreign secretary of the American Geophysical Union, and J. Henning Illies (Geophysical Institute, University of Karlsruhe, Federal Republic of Germany), invited suggestions and comments from the two unions and the national committees in the member countries. Their report, which was completed late in 1978, proposed a new project on the dynamics, origin, and evolution of the lithosphere. This proposal was approved by the IUGS Executive Committee in December 1979 and by the IUGS Council in June 1980. An inter-union steering committee, established in 1979 under the joint chairmanship of Kisslinger and Illies, developed the organizational framework and constitution of the new program. These were approved by resolution of the ICSU Governing Board in September 1980, and the Inter-Union Commission on the Lithosphere (ICL) was established to implement the program. National members of ICSU were urged to establish

  16. Identifying gaps in international food safety regulation.

    PubMed

    McGrady, Benn; Ho, Christina S

    2011-01-01

    The rise in food importation in countries such as the United States, coupled with food safety incidents, has led to increased concern with the safety of imported food. This concern has prompted discussion of how international law and governance mechanisms might enhance food safety. This paper identifies the objectives underlying multilateral approaches to food safety such as raising food safety standards abroad, information sharing and ensuring market access. The paper then explores how these objectives are integrated into the international system and identifies how the current state of the law creates imbalances in the pursuit of these objectives.

  17. Model-based internal wave processing

    SciTech Connect

    Candy, J.V.; Chambers, D.H.

    1995-06-09

    A model-based approach is proposed to solve the oceanic internal wave signal processing problem that is based on state-space representations of the normal-mode vertical velocity and plane wave horizontal velocity propagation models. It is shown that these representations can be utilized to spatially propagate the modal (dept) vertical velocity functions given the basic parameters (wave numbers, Brunt-Vaisala frequency profile etc.) developed from the solution of the associated boundary value problem as well as the horizontal velocity components. Based on this framework, investigations are made of model-based solutions to the signal enhancement problem for internal waves.

  18. Publishing International Counseling Articles

    ERIC Educational Resources Information Center

    Hohenshil, Thomas H.; Amundson, Norman E.

    2011-01-01

    This article begins with a rationale for including international articles in the "Journal of Counseling & Development." Then, 2 general categories of international articles are described. First are articles that provide a general overview of counseling in a particular country. The 2nd category is more general and might involve international…

  19. International Education Programs.

    ERIC Educational Resources Information Center

    Charles, Richard F.

    In response to global changes and a growing focus on international affairs, Foothill and De Anza Colleges have developed a number of international education programs. Since their beginnings, both colleges have hosted full-time students from other countries under the F-1 Visa Program. Another program, Campus Abroad, is a partnership arrangement…

  20. International Education (Working Paper).

    ERIC Educational Resources Information Center

    Gruson, Edward S.

    The history, objectives, and funding patterns for international education are discussed. Attention is directed toward the language and area study centers of the U.S. Office of Education, undergraduate/graduate and scholarly exchange programs, and the support of advanced research in international studies. The main source of funds for language and…

  1. Discipline and Internalization.

    ERIC Educational Resources Information Center

    Hoffman, Martin L.

    1994-01-01

    Although Grusec and Goodnow make interesting suggestions concerning discipline variables that may affect internalization, their ideas are not integrated into a theory, and their definition of internalization is limited because parent-child similarity may result from children's attributing their values to parents. A theory linking discipline and…

  2. Teaching International Relations.

    ERIC Educational Resources Information Center

    Becker, James M.

    The accelerated pace of society suggests that social education be clearly formulated from a conceptual golobal framework, recognizing the oneness of earth and man's sharing of a common fate, and that the curriculum be designed from a point of view toward improving international understanding. Effective approaches in international relations…

  3. BWR internal cracking issues

    SciTech Connect

    Carpenter, C.E. Jr.; Lund, A.L.

    1999-07-01

    The regulatory issues associated with cracking of boiling water reactor (BWR) internals is being addressed by the Nuclear Regulatory Commission (NRC) staff and is the subject of a voluntary industry initiative. The lessons learned from this effort will be applied to pressurized water reactor (PWR) internals cracking issues.

  4. Internal Evaluation, Historically Speaking

    ERIC Educational Resources Information Center

    Mathison, Sandra

    2011-01-01

    The author analyzes the growth and nature of internal evaluation from the 1960s to the present and suggests that internal evaluation has been on the increase because of its perceived importance. Although the 1960s were characterized by a rich intellectual development of evaluation theory and practice, the fiscal conservatism of the 1980s ushered…

  5. International. [SITE 2002 Section].

    ERIC Educational Resources Information Center

    Willis, Dee Anna, Ed.

    This document contains the following papers on international issues from the SITE (Society for Information Technology & Teacher Education) 2002 conference: (1) "The Management of Technological Change within Faculties in International American Schools" (Martine Audeoud); (2) "Going Global: Using a Website Development Project To Teach Technology…

  6. Alberta's International Education Strategy.

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Learning and Teaching Resources Branch.

    Globalization is driving rapid change in knowledge, skills, and innovation. The economic well-being of future generations of Albertans depends on investment in education today to ensure that the knowledge and skills acquired continues to be in demand in international communities. International student recruitment in both the basic education and…

  7. The International Assembly.

    ERIC Educational Resources Information Center

    Gerlach, Jeanne Marcum, Ed.

    2000-01-01

    Looks at the missions and goals of the International Assembly of the National Council of Teachers of English, a global multicultural network promoting communication and cooperation for international exchange of teaching practices, literature, literacy, curriculum development, and research in English. Suggests some criteria to look at when…

  8. Managing International Consulting Projects and International Business Courses Using Virtual Teams

    ERIC Educational Resources Information Center

    Prachyl, Cheryl; Quintanilla, Hector; Gutiérrez, Luis Antonio

    2011-01-01

    The Instituto Tecnologico y de Estudios Superiores de Monterrey and Texas Wesleyan University used technology based courses to enhance internationalization of their curricula. These courses required students to use computer technology as the distance communication medium and to complete an applied international consulting project as part of each…

  9. Cancer from internal emitters

    SciTech Connect

    Boecker, B.B.; Griffith, W.C. Jr.

    1995-10-01

    Irradiation from internal emitters, or internally deposited radionuclides, is an important component of radiation exposures encountered in the workplace, home, or general environment. Long-term studies of human populations exposed to various internal emitters by different routes of exposure are producing critical information for the protection of workers and members of the general public. The purpose of this report is to examine recent developments and discuss their potential importance for understanding lifetime cancer risks from internal emitters. The major populations of persons being studied for lifetime health effects from internally deposited radionuclides are well known: Lung cancer in underground miners who inhaled Rn progeny, liver cancer from persons injected with the Th-containing radiographic contrast medium Thorotrast, bone cancer from occupational or medical intakes of {sup 226}Ra or medical injections of {sup 224}Ra, and thyroid cancer from exposures to iodine radionuclides in the environment or for medical purposes.

  10. Can stock enhancement enhance stocks?

    NASA Astrophysics Data System (ADS)

    Støttrup, J. G.; Sparrevohn, C. R.

    2007-02-01

    Successful stock enhancement or restocking requires a thorough understanding of the ecological processes that provide a potential for stocking within different ecosystems, i.e. determine which factors define the potential for stocking, such as population dynamics, economic cost-benefits, fisheries management and socio-economic impacts. Stocking is not simply a question of aquaculture logistics (i.e. the ability to produce a sufficient number of fry relative to the magnitude of the natural recruitment within the system), nor should it be a new outlet for aquaculture production. Quantitative targets should be set and the expected performance of the stocking tested. Potential loopholes, such as post-release mortality and habitat requirements related to the release, should be examined and resolved. If properly managed, stocking may lead to an increase in population, contribute to the local fishery and/or lead to an increase in the spawning stock biomass. The criteria for stocking are discussed in this paper using examples from flatfish and cod stocking programmes within specific ecosystems.

  11. Preconception Care in International Settings

    PubMed Central

    Parker, Christopher; Atrash, Hani

    2006-01-01

    Objectives: This literature review briefly describes international programs, policies, and activities related to preconception care and resulting pregnancy outcomes. Methods: Electronic databases were searched and findings supplemented with secondary references cited in the original articles as well as textbook chapters, declarations, reports, and recommendations. Results: Forty-two articles, book chapters, declarations, and other published materials were reviewed. Policies, programs, and recommendations related to preconceptional health promotion exist worldwide and comprise a readily identifiable component of historic and modern initiatives pertaining to women's health, reproductive freedom, and child survival. Conclusions: The integration of preconception care services within a larger maternal and child health continuum of care is well aligned with a prevention-based approach to enhancing global health. PMID:16710763

  12. Waves: Internal Tides

    NASA Technical Reports Server (NTRS)

    Ray, Richard D.

    1999-01-01

    Oceanic internal tides are internal waves with tidal periodicities. They are ubiquitous throughout the ocean, although generally more pronounced near large bathymetric features such as mid-ocean ridges and continental slopes. The internal vertical displacements associated with these waves can be extraordinarily large. Near some shelf breaks where the surface tides are strong, internal displacements (e.g., of an isothermal surface) can exceed 200 meters. Displacements of 10 meters in the open ocean are not uncommon. The associated current velocities are usually comparable to or larger than the currents of the surface tide. On continental shelves internal tides can occasionally generate packets of internal solitons, which are detectable in remote sensing imagery. Other common nonlinear features are generation of higher harmonics (e.g., 6-hr waves) and wave breaking. Internal tides are known to be an important energy source for mixing of shelf waters. Recent research suggests that they may also be a significant energy source for deep-ocean mixing.

  13. NASA International Environmental Partnerships

    NASA Technical Reports Server (NTRS)

    Lewis, Pattie; Valek, Susan

    2010-01-01

    For nearly five decades, the National Aeronautics and Space Administration (NASA) has been preeminent in space exploration. NASA has landed Americans on the moon, robotic rovers on Mars, and led cooperative scientific endeavors among nations aboard the International Space Station. But as Earth's population increases, the environment is subject to increasing challenges and requires more efficient use of resources. International partnerships give NASA the opportunity to share its scientific and engineering expertise. They also enable NASA to stay aware of continually changing international environmental regulations and global markets for materials that NASA uses to accomplish its mission. Through international partnerships, NASA and this nation have taken the opportunity to look globally for solutions to challenges we face here on Earth. Working with other nations provides NASA with collaborative opportunities with the global science/engineering community to explore ways in which to protect our natural resources, conserve energy, reduce the use of hazardous materials in space and earthly applications, and reduce greenhouse gases that potentially affect all of Earth's inhabitants. NASA is working with an ever-expanding list of international partners including the European Union, the European Space Agency and, especially, the nation of Portugal. Our common goal is to foster a sustainable future in which partners continue to explore the universe while protecting our home planet's resources for future generations. This brochure highlights past, current, and future initiatives in several important areas of international collaboration that can bring environmental, economic, and other benefits to NASA and the wider international space community.

  14. Internal tide oceanic tomography

    NASA Astrophysics Data System (ADS)

    Zhao, Zhongxiang

    2016-09-01

    A concept of internal tide oceanic tomography (ITOT) is proposed to monitor ocean warming on a global scale. ITOT is similar to acoustic tomography, but that work waves are internal tides. ITOT detects ocean temperature changes by precisely measuring travel time changes of long-range propagating internal tides. The underlying principle is that upper ocean warming strengthens ocean stratification and thus increases the propagation speed of internal tides. This concept is inspired by recent advances in observing internal tides by satellite altimetry. In particular, a plane wave fit method can separately resolve multiple internal tidal waves and thus accurately determines the phase of each wave. Two examples are presented to demonstrate the feasibility and usefulness of ITOT. In the eastern tropical Pacific, the yearly time series of travel time changes of the M2 internal tide is closely correlated with the El Niño-Southern Oscillation index. In the North Atlantic, significant interannual variations and bidecadal trends are observed and consistent with the changes in ocean heat content measured by Argo floats. ITOT offers a long-term, cost-effective, environmentally friendly technique for monitoring global ocean warming. Future work is needed to quantify the accuracy of this technique.

  15. Global Floods and Droughts Simulation to Support International Flood Initiative and International Drought Initiative of the UNESCO International Hydrological Program

    NASA Astrophysics Data System (ADS)

    Gusyev, M.; Takeuchi, K.; Magome, J.; Masood, M.

    2015-12-01

    One of the main achievements of the IHD/IHP programs is the promotion and enhancement of hydrological data exchange within the global water community. World Catalogue of Very Large Floods, World Water Balance and Water Resources of the Earth are the great examples of some initial collaborative efforts and the FRIEND and Catalogue of Rivers for Southeast Asia and the Pacific are the more recent outcomes. Along with similar efforts by WMO, FAO, IGBP, CEOS and many other national and international institutes, the global hydrological monitoring and nowcast have made a considerable progress last decade and are about to put into practice. Such efforts include global streamflow alert system of U Maryland and GFAS-streamflow of ICHARM and U Yamanshi. Especially the recent achievements of GFAS-streamflow support the current efforts of IHP International Flood Initiative (IFI) and International Drought Initiatives (IDI) by global nowcasts and easily visible indicators in 20-km resolution.

  16. International energy annual 1996

    SciTech Connect

    1998-02-01

    The International Energy Annual presents an overview of key international energy trends for production, consumption, imports, and exports of primary energy commodities in over 220 countries, dependencies, and areas of special sovereignty. Also included are population and gross domestic product data, as well as prices for crude oil and petroleum products in selected countries. Renewable energy reported in the International Energy Annual includes hydroelectric power, geothermal, solar, and wind electric power, biofuels energy for the US, and biofuels electric power for Brazil. New in the 1996 edition are estimates of carbon dioxide emissions from the consumption of petroleum and coal, and the consumption and flaring of natural gas. 72 tabs.

  17. International petroleum statistics report

    SciTech Connect

    1995-10-01

    The International Petroleum Statistics Report is a monthly publication that provides current international oil data. This report presents data on international oil production, demand, imports, exports and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). Section 2 presents an oil supply/demand balance for the world, in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries.

  18. International Space Station technology demonstrations

    NASA Astrophysics Data System (ADS)

    Holt, Alan C.

    1998-01-01

    The International Space Station (ISS) has the capability to test and demonstrate, and otherwise assist in the development and validation, of a wide range of advanced technologies. Technology tests and demonstrations for advanced communication systems, closed-loop environmental control systems, advanced power storage and generation systems, advanced electric and electromagnetic propulsion systems, and others are being assessed for inclusion in an ISS Pre-Planned Program Improvement (P3I), Technology/Improvement Roadmap. The P3I roadmap is an integrated set of technology and improvement requirements for: (1) ISS subsystem upgrades and improvements (addressing maintenance, logistics, sustainability, and enhancement functions), (2) payload hardware technology infusion, (3) ISS/Exploration technology development and tests (dual use/benefits), and (4) Engineering Research and Technology payloads. As examples of the International Space Station's technology testbed capabilities, implementation approaches for three types of propulsion technology demonstrations and research are described: (1) electric and electromagnetic propulsion technologies and systems (NASA Lewis Research Center), (2) technologies and sub-systems for a variable specific impulse (Isp), magnetoplasma rocket (VASIMR), (Advanced Propulsion Lab, Sonny Carter Training Facility, Houston, Tx), and (3) candidates for innovative, deep space propulsion technology research and demonstrations (projections based on NASA Advanced Space Transportation Program, Propulsion Research and other R.&D activities.).

  19. Improving Data Mobility & Management for International Cosmology

    SciTech Connect

    Borrill, Julian; Dart, Eli; Gore, Brooklin; Habib, Salman; Myers, Steven T.; Nugent, Peter; Petravick, Don; Thomas, Rollin

    2015-10-02

    In February 2015 the third workshop in the CrossConnects series, with a focus on Improving Data Mobility & Management for International Cosmology, was held at Lawrence Berkeley National Laboratory. Scientists from fields including astrophysics, cosmology, and astronomy collaborated with experts in computing and networking to outline strategic opportunities for enhancing scientific productivity and effectively managing the ever-increasing scale of scientific data.

  20. The Internal Audit.

    ERIC Educational Resources Information Center

    Kuhn, Robert H.

    1981-01-01

    Internal control comprises the plan of organization and all the coordinate methods and measures adopted within a school system to safeguard its assets, check the reliability of its accounting data, promote operational efficiency, and encourage adherence to prescribed policies. (Author)

  1. International Lymphoma Epidemiology Consortium

    Cancer.gov

    The InterLymph Consortium, or formally the International Consortium of Investigators Working on Non-Hodgkin's Lymphoma Epidemiologic Studies, is an open scientific forum for epidemiologic research in non-Hodgkin's lymphoma.

  2. International petroleum statistics report

    SciTech Connect

    1996-12-01

    This report presents data on international oil production, demand, imports, and stocks. World oil production and OECD demand data are for the years 1970 through 1995; stocks from 1973 through 1995, and trade from 1985 through 1995.

  3. Globalisation of international health.

    PubMed

    Walt, G

    1998-02-01

    40 years ago, activities in international health were the domain of WHO, governments (based on bilateral agreements), and non-governmental organisations. This has changed. Today, new players (such as the World Bank and, increasingly, the World Trade Organisation) have an influence on international health. As globalisation of trade and markets takes hold, new coalitions and alliances are forming to examine and deal with the direct and indirect consequences on health. This paper examines the changing context of cooperation in international health, and voices concerns about rising potential inequalities in health, both within and between countries. The question of how such changes will affect the actions of organisations working in international health is also addressed.

  4. International petroleum statistics report

    SciTech Connect

    1996-03-01

    This report presents data on international oil production, demand, imports, exports, and stocks. World oil production and OECD demand data are for the years 1970 through 1994; OECD stocks from 1973 through 1994; and OECD trade from 1984 through 1994.

  5. International Higher Education Bibliography.

    ERIC Educational Resources Information Center

    Lulat, Y. G-M.

    1988-01-01

    One in a series of bibliographies of articles in international higher education journals lists items on a variety of administrative, financial, faculty, student, curricular, and related issues. Articles on specific geographic regions are categorized separately. (MSE)

  6. Geoscientists for international development

    USGS Publications Warehouse

    Hastings, David A.

    1980-01-01

    Professional societies are usually concerned with the advancement of scientific knowledge, but a relative newcomer to the international scene has a different focus - geoscience development in the Third World. David Hastings, a member of AGID, explains.

  7. Internal resonance for nonlinear vibration energy harvesting

    NASA Astrophysics Data System (ADS)

    Cao, D. X.; Leadenham, S.; Erturk, A.

    2015-11-01

    The transformation of waste vibration energy into low-power electricity has been heavily researched over the last decade to enable self-sustained wireless electronic components. Monostable and bistable nonlinear oscillators have been explored by several research groups in an effort to enhance the frequency bandwidth of operation. Linear two-degree-of-freedom (2-DOF) configurations as well as the combination of a nonlinear single-DOF harvester with a linear oscillator to constitute a nonlinear 2-DOF harvester have also been explored to develop broadband energy harvesters. In the present work, the concept of nonlinear internal resonance in a continuous frame structure is explored for broadband energy harvesting. The L-shaped beam-mass structure with quadratic nonlinearity was formerly studied in the nonlinear dynamics literature to demonstrate modal energy exchange and the saturation phenomenon when carefully tuned for two-to-one internal resonance. In the current effort, piezoelectric coupling and an electrical load are introduced, and electromechanical equations of the L-shaped energy harvester are employed to explore primary resonance behaviors around the first and the second linear natural frequencies for bandwidth enhancement. Simulations using approximate analytical frequency response equations as well as numerical solutions reveal significant bandwidth enhancement as compared to a typical linear 2-DOF counterpart. Vibration and voltage responses are explored, and the effects of various system parameters on the overall dynamics of the internal resonance-based energy harvesting system are reported.

  8. Special issue "International CAWSES-II Symposium"

    NASA Astrophysics Data System (ADS)

    Yamamoto, Mamoru; Shiokawa, Kazuo; Nakamura, Takuji; Gopalswamy, Nat

    2016-02-01

    This special issue gathered papers from the International CAWSES-II Symposium (November 18-22, 2013 at Nagoya University, Japan). Climate and Weather of the Sun-Earth System II (CAWSES-II) is an international scientific program sponsored by Scientific Committee on Solar-Terrestrial Physics (SCOSTEP) that continued from 2009 to 2013. The program was established with the aim of significantly enhancing our understanding of the space environment and its impacts on life and society. The International CAWSES-II Symposium was successful with 388 presentations; and from that, 38 papers were published in this special issue. In this preface, we briefly discuss the contents of the special issue as well as the CAWSES-II review papers published in Progress in Earth and Planetary Science (PEPS) in 2014-2015.

  9. (International meetings on ecology)

    SciTech Connect

    DeAngelis, D.L.; Garten, C.T. Jr.; Turner, M.G.

    1990-09-25

    the travelers attended the Fifth International Congress of Ecology (INTECOL) in Yokohama, Japan, and two presented invited papers and chaired symposia. One traveler also attended the OJI International Seminar in Gifu, Japan and the Fukuoka Symposium on Theoretical Ecology in Fukuoka, Japan and presented invited papers. At these scientific gatherings, a large number of symposia and specific presentations were relevant to current research at Oak Ridge National Laboratory (ORNL), especially in the areas of landscape dynamics, plant physiology, and aquatic ecosystems.

  10. International petroleum statistics report

    SciTech Connect

    Not Available

    1994-05-01

    This monthly publication provides current international oil data. The Report presents data on international oil production, demand, imports, exports, and stocks. Section 1 contains time series data on world oil production, and on oil demand and stocks in the OECD. Section 2 presents an oil supply/demand balance for the world. Section 3 presents data on oil imports by OECD countries. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries.

  11. Criteria for internal auditing.

    PubMed

    Holder, W W; Clay, R J

    1979-01-01

    An effective, inclusive internal auditing endeavor should help assure hospital managements that (1) an adequate system of internal control exists to assure the safeguarding of assets and the reliability of data produced by the financial information system, (2) uneconomic operating practices are detected promptly so they can be remedied, and (3) program results and effectiveness levels are of sufficiently high quality to demonstrate managerial competence.

  12. The international uranium market

    SciTech Connect

    Neff, T.

    1984-01-01

    Shortages, glut, political manipulation and worries about security have all marked the international trade in uranium. In this book, the director of the International Energy Studies Program of the MIT Energy Laboratory sorts out these factors, looks closely at the position of a number of countries, and speculates on the future of a market in which supply will exceed demand, costs will vary widely, and governments will continue to be directly involved for as far ahead as anyone can see.

  13. Tools for Tapping an Intercultural Gold Mine: Integrating International Staff into Your Camp Program.

    ERIC Educational Resources Information Center

    Harwood, Bill

    2001-01-01

    International camp counselors can enhance the camp environment and improve marketability. Guidelines for achieving a mutually beneficial international camp experience include hiring staff from a variety of countries, establishing a relationship before arrival, actively incorporating international staff into the camp community, incorporating…

  14. SPACE: Enhancing Life on Earth. Proceedings Report

    NASA Technical Reports Server (NTRS)

    Hobden, Alan (Editor); Hobden, Beverly (Editor); Bagley, Larry E. (Editor); Bolton, Ed (Editor); Campaigne, Len O. (Editor); Cole, Ron (Editor); France, Marty (Editor); Hand, Rich (Editor); McKinley, Cynthia (Editor); Zimkas, Chuck (Editor)

    1996-01-01

    The proceedings of the 12th National Space Symposium on Enhancing Life on Earth is presented. Technological areas discussed include: Space applications and cooperation; Earth sensing, communication, and navigation applications; Global security interests in space; and International space station and space launch capabilities. An appendices that include featured speakers, program participants, and abbreviation & acronyms glossary is also attached.

  15. Female Athletes and Performance-Enhancer Usage

    ERIC Educational Resources Information Center

    Fralinger, Barbara K.; Pinto-Zipp, Genevieve; Olson, Valerie; Simpkins, Susan

    2007-01-01

    The purpose of this study was to develop a knowledge base on factors associated with performance-enhancer usage among female athletes at the high school level in order to identify markers for a future prevention-education program. The study used a pretest-only, between-subjects Likert Scale survey to rank the importance of internal and external…

  16. International Space Education Outreach: Taking Exploration to the Global Classroom

    NASA Technical Reports Server (NTRS)

    Dreschel, T. W.; Lichtenberger, L. A.; Chetirkin, P. V.; Garner, L. C.; Barfus, J. R.; Nazarenko, V. I.

    2005-01-01

    With the development of the International Space Station and the need for international collaboration for returning to the moon and developing a mission to Mars, NASA has embarked on developing international educational programs related to space exploration. In addition, with the explosion of educational technology, linking students on a global basis is more easily accomplished. This technology is bringing national and international issues into the classroom, including global environmental issues, the global marketplace, and global collaboration in space. We present the successes and lessons learned concerning international educational and public outreach programs that we have been involved in for NASA as well as the importance of sustaining these international peer collaborative programs for the future generations. These programs will undoubtedly be critical in enhancing the classroom environment and will affect the achievements in and attitudes towards science, technology, engineering and mathematics.

  17. Fluorescence Enhancement of Molecules Inside a Gold Nanomatryoshka

    PubMed Central

    2015-01-01

    Metallic nanoparticles exhibiting plasmonic Fano resonances can provide large enhancements of their internal electric near field. Here we show that nanomatryoshkas, nanoparticles consisting of an Au core, an interstitial nanoscale SiO2 layer, and an Au shell layer, can selectively provide either a strong enhancement or a quenching of the spontaneous emission of fluorophores dispersed within their internal dielectric layer. This behavior can be understood by taking into account the near-field enhancement induced by the Fano resonance of the nanomatryoshka, which is responsible for enhanced absorption of the fluorophores incorporated into the nanocomplex. The combination of compact size and enhanced light emission with internal encapsulation of the fluorophores for increased biocompatibility suggests outstanding potential for this type of nanoparticle complex in biomedical applications. PMID:24738706

  18. Analytical model of internally coupled ears.

    PubMed

    Vossen, Christine; Christensen-Dalsgaard, Jakob; van Hemmen, J Leo

    2010-08-01

    Lizards and many birds possess a specialized hearing mechanism: internally coupled ears where the tympanic membranes connect through a large mouth cavity so that the vibrations of the tympanic membranes influence each other. This coupling enhances the phase differences and creates amplitude differences in the tympanic membrane vibrations. Both cues show strong directionality. The work presented herein sets out the derivation of a three dimensional analytical model of internally coupled ears that allows for calculation of a complete vibration profile of the membranes. The analytical model additionally provides the opportunity to incorporate the effect of the asymmetrically attached columella, which leads to the activation of higher membrane vibration modes. Incorporating this effect, the analytical model can explain measurements taken from the tympanic membrane of a living lizard, for example, data demonstrating an asymmetrical spatial pattern of membrane vibration. As the analytical calculations show, the internally coupled ears increase the directional response, appearing in large directional internal amplitude differences (iAD) and in large internal time differences (iTD). Numerical simulations of the eigenfunctions in an exemplary, realistically reconstructed mouth cavity further estimate the effects of its complex geometry.

  19. Analytical model of internally coupled ears.

    PubMed

    Vossen, Christine; Christensen-Dalsgaard, Jakob; van Hemmen, J Leo

    2010-08-01

    Lizards and many birds possess a specialized hearing mechanism: internally coupled ears where the tympanic membranes connect through a large mouth cavity so that the vibrations of the tympanic membranes influence each other. This coupling enhances the phase differences and creates amplitude differences in the tympanic membrane vibrations. Both cues show strong directionality. The work presented herein sets out the derivation of a three dimensional analytical model of internally coupled ears that allows for calculation of a complete vibration profile of the membranes. The analytical model additionally provides the opportunity to incorporate the effect of the asymmetrically attached columella, which leads to the activation of higher membrane vibration modes. Incorporating this effect, the analytical model can explain measurements taken from the tympanic membrane of a living lizard, for example, data demonstrating an asymmetrical spatial pattern of membrane vibration. As the analytical calculations show, the internally coupled ears increase the directional response, appearing in large directional internal amplitude differences (iAD) and in large internal time differences (iTD). Numerical simulations of the eigenfunctions in an exemplary, realistically reconstructed mouth cavity further estimate the effects of its complex geometry. PMID:20707461

  20. Enhanced Micellar Catalysis LDRD.

    SciTech Connect

    Betty, Rita G.; Tucker, Mark D; Taggart, Gretchen; Kinnan, Mark K.; Glen, Crystal Chanea; Rivera, Danielle; Sanchez, Andres; Alam, Todd Michael

    2012-12-01

    The primary goals of the Enhanced Micellar Catalysis project were to gain an understanding of the micellar environment of DF-200, or similar liquid CBW surfactant-based decontaminants, as well as characterize the aerosolized DF-200 droplet distribution and droplet chemistry under baseline ITW rotary atomization conditions. Micellar characterization of limited surfactant solutions was performed externally through the collection and measurement of Small Angle X-Ray Scattering (SAXS) images and Cryo-Transmission Electron Microscopy (cryo-TEM) images. Micellar characterization was performed externally at the University of Minnesotas Characterization Facility Center, and at the Argonne National Laboratory Advanced Photon Source facility. A micellar diffusion study was conducted internally at Sandia to measure diffusion constants of surfactants over a concentration range, to estimate the effective micelle diameter, to determine the impact of individual components to the micellar environment in solution, and the impact of combined components to surfactant phase behavior. Aerosolized DF-200 sprays were characterized for particle size and distribution and limited chemical composition. Evaporation rates of aerosolized DF-200 sprays were estimated under a set of baseline ITW nozzle test system parameters.

  1. Enhanced local tomography

    DOEpatents

    Katsevich, Alexander J.; Ramm, Alexander G.

    1996-01-01

    Local tomography is enhanced to determine the location and value of a discontinuity between a first internal density of an object and a second density of a region within the object. A beam of radiation is directed in a predetermined pattern through the region of the object containing the discontinuity. Relative attenuation data of the beam is determined within the predetermined pattern having a first data component that includes attenuation data through the region. In a first method for evaluating the value of the discontinuity, the relative attenuation data is inputted to a local tomography function .function..sub..LAMBDA. to define the location S of the density discontinuity. The asymptotic behavior of .function..sub..LAMBDA. is determined in a neighborhood of S, and the value for the discontinuity is estimated from the asymptotic behavior of .function..sub..LAMBDA.. In a second method for evaluating the value of the discontinuity, a gradient value for a mollified local tomography function .gradient..function..sub..LAMBDA..epsilon. (x.sub.ij) is determined along the discontinuity; and the value of the jump of the density across the discontinuity curve (or surface) S is estimated from the gradient values.

  2. Temporary internal pacing.

    PubMed

    Ortiz Díaz-Miguel, R; Gómez Grande, M L

    2014-12-01

    Technology and insertion techniques for cardiac temporary internal pacing have experienced a remarkable development over the last few years. Despite this fact, the procedure continues to have potentially fatal associated complications. Temporary internal pacing is indicated for the treatment of bradyarrhythmias or tachyarrhythmias refractory to conventional treatment, or arrhythmias causing cardiovascular or clinical instability of the patient. On the other hand, the indications of temporary cardiac pacing are far less well defined than those of permanent pacing. Since the decision of implementing temporary pacing is complex and delicate, it should always be carefully considered, and over-indication should be avoided. We must base these decisions on robust knowledge of the arrhythmias that may benefit from temporary internal pacing, and should also acquire the habit of considering external temporary pacing among other less aggressive treatments, and to make the best use of new technologies such as echocardiography that add accuracy to the procedure. PMID:24786750

  3. The International Space University

    NASA Technical Reports Server (NTRS)

    Davidian, Kenneth J.

    1990-01-01

    The International Space University (ISU) was founded on the premise that any major space program in the future would require international cooperation as a necessary first step toward its successful completion. ISU is devoted to being a leading center for educating future authorities in the world space industry. ISU's background, goals, current form, and future plans are described. The results and benefits of the type of education and experience gained from ISU include technical reports describing the design projects undertaken by the students, an exposure to the many different disciplines which are a part of a large space project, an awareness of the existing activities from around the world in the space community, and an international professional network which spans all aspects of space activities and covers the globe.

  4. International energy annual 1997

    SciTech Connect

    1999-04-01

    The International Energy Annual presents an overview of key international energy trends for production, consumption, imports, and exports of primary energy commodities in over 220 countries, dependencies, and areas of special sovereignty. Also included are population and gross domestic product data, as well as prices for crude oil and petroleum products in selected countries. Renewable energy reported in the International Energy Annual includes hydroelectric power and geothermal, solar, and wind electric power. Also included are biomass electric power for Brazil and the US, and biomass, geothermal, and solar energy produced in the US and not used for electricity generation. This report is published to keep the public and other interested parties fully informed of primary energy supplies on a global basis. The data presented have been largely derived from published sources. The data have been converted to units of measurement and thermal values (Appendices E and F) familiar to the American public. 93 tabs.

  5. International energy outlook 1994

    SciTech Connect

    Not Available

    1994-07-01

    The International Energy Outlook 1994 (IEO94) presents an assessment by the Energy Information Administration (EIA) of the outlook for international energy markets between 1990 and 2010. The report is provided as a statistical service to assist energy managers and analysts, both in government and in the private sector. These forecasts are used by international agencies, Federal and State governments, trade associations, and other planners and decisionmakers. They are published pursuant to the Depart. of Energy Organization Act of 1977 (Public Law 95-91), Section 205(c). The IEO94 projections are based on US and foreign government policies in effect on October 1, 1993-which means that provisions of the Climate Change Action Plan unveiled by the Administration in mid-October are not reflected by the US projections.

  6. [International malpractice law].

    PubMed

    Stellpflug, M H

    2001-10-01

    According to German Civil Law the liability of a physician in telemedicine can be based on the breach of contractual duties or tort. In telemedicine doctor and patient are separated by distance. In the case of cross border telemedicine Medical Malpractice Law becomes an international issue with many new questions arising. The rules and regulations of "private international law" determine which law has to be applied. The German private international law allows the patient to choose either the law of the state in which the doctor acts or that state in which the therapeutical damage is being suffered. Another important question arises in determining the jurisdiction (of a court). The European agreements give the patient the right to choose. A "choice of jurisdiction clause" or a "choice of law clause" can help to decide with binding force which law and what jurisdiction has to be applied. However, various regulations concerned with consumer protection restrict the permission of such agreements.

  7. [International malpractice law].

    PubMed

    Stellpflug, M H

    2001-10-01

    According to German Civil Law the liability of a physician in telemedicine can be based on the breach of contractual duties or tort. In telemedicine doctor and patient are separated by distance. In the case of cross border telemedicine Medical Malpractice Law becomes an international issue with many new questions arising. The rules and regulations of "private international law" determine which law has to be applied. The German private international law allows the patient to choose either the law of the state in which the doctor acts or that state in which the therapeutical damage is being suffered. Another important question arises in determining the jurisdiction (of a court). The European agreements give the patient the right to choose. A "choice of jurisdiction clause" or a "choice of law clause" can help to decide with binding force which law and what jurisdiction has to be applied. However, various regulations concerned with consumer protection restrict the permission of such agreements. PMID:11688223

  8. Myalgic encephalomyelitis: International Consensus Criteria

    PubMed Central

    Carruthers, B M; van de Sande, M I; De Meirleir, K L; Klimas, N G; Broderick, G; Mitchell, T; Staines, D; Powles, A C P; Speight, N; Vallings, R; Bateman, L; Baumgarten-Austrheim, B; Bell, D S; Carlo-Stella, N; Chia, J; Darragh, A; Jo, D; Lewis, D; Light, A R; Marshall-Gradisbik, S; Mena, I; Mikovits, J A; Miwa, K; Murovska, M; Pall, M L; Stevens, S

    2011-01-01

    , Japan; A. Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia; Department of Biochemistry & Basic Medical Sciences, Washington State University, Portland, OR; Department of Sports Sciences, University of the Pacific, Stockton, CA USA). Myalgic encephalomyelitis: International Consensus Criteria (Review). J Intern Med 2011; 270: 327–338. The label ‘chronic fatigue syndrome’ (CFS) has persisted for many years because of the lack of knowledge of the aetiological agents and the disease process. In view of more recent research and clinical experience that strongly point to widespread inflammation and multisystemic neuropathology, it is more appropriate and correct to use the term ‘myalgic encephalomyelitis’ (ME) because it indicates an underlying pathophysiology. It is also consistent with the neurological classification of ME in the World Health Organization’s International Classification of Diseases (ICD G93.3). Consequently, an International Consensus Panel consisting of clinicians, researchers, teaching faculty and an independent patient advocate was formed with the purpose of developing criteria based on current knowledge. Thirteen countries and a wide range of specialties were represented. Collectively, members have approximately 400 years of both clinical and teaching experience, authored hundreds of peer-reviewed publications, diagnosed or treated approximately 50 000 patients with ME, and several members coauthored previous criteria. The expertise and experience of the panel members as well as PubMed and other medical sources were utilized in a progression of suggestions/drafts/reviews/revisions. The authors, free of any sponsoring organization, achieved 100% consensus through a Delphi-type process. The scope of this paper is limited to criteria of ME and their application. Accordingly, the criteria reflect the complex symptomatology. Operational notes enhance clarity and specificity by providing guidance in the

  9. ILO - International Migration Programme.

    PubMed

    Boudraa, Miriam

    2011-01-01

    In a wide International Context characterised not only by the economical development but also by the social, cultural, political and individual development, we witness more and more to a exchange between the developed and the developing countries, which can be translated especially in the migration of the work force. In theory, all countries are either countries of origin either countries of transit or destination, and they are all responsible for the rights of migrant workers by promoting the rights, by monitoring and by preventing the abusive conditions. The process of migration of the workforce can be divided into three stages: the first coincides with the period prior to departure, the second is represented by the aftermath of the departure and the period of stay in the country of destination, the third stage corresponds to the return in the country of origin. The workers must be protected throughout this process by the international organizations that perform the catalytic role of communication and exchange between countries, for the only purpose of protecting the rights of immigrant and/or immigrants workers. The responsibility for the protection of workers is divided among the various players in the International Labour Organisation. Every country has to apply measures according to the international standards regarding workers' rights, standards that guide the various countries in the formulation and implementation of their policies and legislation. These standards are suggested by International Conventions, the ILO Conventions and other international instruments such as the human rights instrument. There has been a big step forward once the ILO Fundamental Conventions and Conventions on Migrant Workers where implemented and this implementation represented the use of the Guidelines "ILO Multilateral Framework on Labour Migration".

  10. ILO - International Migration Programme.

    PubMed

    Boudraa, Miriam

    2011-01-01

    In a wide International Context characterised not only by the economical development but also by the social, cultural, political and individual development, we witness more and more to a exchange between the developed and the developing countries, which can be translated especially in the migration of the work force. In theory, all countries are either countries of origin either countries of transit or destination, and they are all responsible for the rights of migrant workers by promoting the rights, by monitoring and by preventing the abusive conditions. The process of migration of the workforce can be divided into three stages: the first coincides with the period prior to departure, the second is represented by the aftermath of the departure and the period of stay in the country of destination, the third stage corresponds to the return in the country of origin. The workers must be protected throughout this process by the international organizations that perform the catalytic role of communication and exchange between countries, for the only purpose of protecting the rights of immigrant and/or immigrants workers. The responsibility for the protection of workers is divided among the various players in the International Labour Organisation. Every country has to apply measures according to the international standards regarding workers' rights, standards that guide the various countries in the formulation and implementation of their policies and legislation. These standards are suggested by International Conventions, the ILO Conventions and other international instruments such as the human rights instrument. There has been a big step forward once the ILO Fundamental Conventions and Conventions on Migrant Workers where implemented and this implementation represented the use of the Guidelines "ILO Multilateral Framework on Labour Migration". PMID:22073693

  11. The international RESPO network

    SciTech Connect

    1997-12-01

    Winrock International, with sponsorship from the Center for Environment of the U.S. Agency for International Development (USAID) and the U.S. Export Council for Renewable Energy (US/ECRE), is building a global network of non-governmental organizations to help catalyze the use of renewable energy technologies for rural energy supply in developing countries. Known as the Renewable Energy Project Support Offices (REPSOs), these in-country facilities are managed by local institutions in coordination with Winrock. REPSOs provide an array of technical and financial support services to help developers identify and evaluate opportunities for renewable energy projects.

  12. (International seminar on limnology)

    SciTech Connect

    Kimmel, B.L.

    1991-03-05

    The traveler attended the Second Week on Limnology, the second of a four-part series of week-long conferences, which collectively will comprise the International Seminar on Limnology. These conferences are being organized and sponsored by the National Water Commission of Mexico for the purpose of upgrading the limnological knowledge, experience, and international contacts of limnologists, water resources scientists, and engineers in Mexico. This particular meeting focused on limnological research, water resources development, water resources problems, and lake restoration efforts occurring throughout the world. The traveler presented an invited lecture entitled Understanding Reservoirs as Aquatic Ecosystems'' and served as the moderator of a day-long session on Selected Topics.''

  13. INTERNAL CUTTING DEVICE

    DOEpatents

    Russell, W.H. Jr.

    1959-06-30

    A device is described for removing material from the interior of a hollow workpiece so as to form a true spherical internal surface in a workpiece, or to cut radial slots of an adjustable constant depth in an already established spherical internal surface. This is accomplished by a spring loaded cutting tool adapted to move axially wherein the entire force urging the tool against the workpiece is derived from the spring. Further features of importance involve the provision of a seal between the workpiece and the cutting device and a suction device for carrying away particles of removed material.

  14. International occupational health.

    PubMed

    LaDou, Joseph

    2003-08-01

    Working conditions for the majority of the world's workers do not meet the minimum standards and guidelines set by international agencies. Occupational health and safety laws cover only about 10 percent of the population in developing countries, omitting many major hazardous industries and occupations. With rare exception, most countries defer to the United Nations the responsibility for international occupational health. The UN's international agencies have had limited success in bringing occupational health to the industrializing countries. The International Labor Organization (ILO) conventions are intended to guide all countries in the promotion of workplace safety and in managing occupational health and safety programs. ILO conventions and recommendations on occupational safety and health are international agreements that have legal force only if they are ratified by ILO member states. The most important ILO Convention on Occupational Safety and Health has been ratified by only 37 of the 175 ILO member states. Only 23 countries have ratified the ILO Employment Injury Benefits Convention that lists occupational diseases for which compensation should be paid. The World Health Organization (WHO) is responsible for the technical aspects of occupational health and safety, the promotion of medical services and hygienic standards. Limited WHO and ILO funding severely impedes the development of international occupational health. The U.S. reliance on international agencies to promote health and safety in the industrializing countries is not nearly adequate. This is particularly true if occupational health continues to be regarded primarily as an academic exercise by the developed countries, and a budgetary triviality by the international agencies. Occupational health is not a goal achievable in isolation. It should be part of a major institutional development that touches and reforms every level of government in an industrializing country. Occupational health and safety

  15. Internal combustion chamber

    SciTech Connect

    Schmitz, D.L.

    1988-03-08

    In combination with a high-powered reciprocating piston internal combustion engine, an internal combustion cylinder assembly is described comprising: a cylinder head made of weldable material; a cylinder liner for containing and guiding a reciprocating piston of the engine, a coolant jacket adapted to receive a cooling fluid, mounted on and surrounding the cylinder liner, the jacket being attached to the cylinder head and detachably supported by the cylinder liner, and forming a cooling chamber around the cylinder liner; means to supply the cooling fluid to the cooling chamber and to discharge the cooling fluid therefrom.

  16. Internationalism and Globalization as Contexts for International Education

    ERIC Educational Resources Information Center

    Cambridge, James; Thompson, Jeff

    2004-01-01

    A problem with the construction of an inclusive definition of international education is that the word 'international' has a variety of connotations. It is proposed that the term 'international education' is ambiguous because it appears to refer to contrasting usages in educational studies. International education is frequently discussed in the…

  17. The hitchhiker's guide to altruism: gene-culture coevolution, and the internalization of norms.

    PubMed

    Gintis, Herbert

    2003-02-21

    An internal norm is a pattern of behavior enforced in part by internal sanctions, such as shame, guilt and loss of self-esteem, as opposed to purely external sanctions, such as material rewards and punishment. The ability to internalize norms is widespread among humans, although in some so-called "sociopaths", this capacity is diminished or lacking. Suppose there is one genetic locus that controls the capacity to internalize norms. This model shows that if an internal norm is fitness enhancing, then for plausible patterns of socialization, the allele for internalization of norms is evolutionarily stable. This framework can be used to model Herbert Simon's (1990) explanation of altruism, showing that altruistic norms can "hitchhike" on the general tendency of internal norms to be personally fitness-enhancing. A multi-level selection, gene-culture coevolution argument then explains why individually fitness-reducing internal norms are likely to be prosocial as opposed to socially harmful.

  18. The international seismological observing period in Africa

    USGS Publications Warehouse

    Engdahl, E.R.; Bergman, Eric A.

    1992-01-01

    The International Seismological Observing Period (ISOP) is a specific time interval designated for enhanced international cooperation in the collection and dissemination of observatory measurements from the global seismographic network. The primary purpose of the ISOP is to strengthen the international infrastructure that supports current seismological practice and increase the cooperation among nations that operate seismological observatories. Measurements, reported by the existing global network and compiled by agencies such as the International Seismological Centre (ISC), are providing new information about earthquakes and the structure of the Earth of fundamental importance to the Earth sciences. However, these data represent but a small fraction of the information contained in the seismograms. One of the goals of the ISOP is to collect improved sets of data. In particular, the measurement and reporting of later-arriving phases, during a fixed ISOP period, from earthquakes selected for detailed observation by the cooperating stations will be encouraged. The use of advanced, digital instrumentation provides an unprecedented opportunity for enhancing the methods of seismogram interpretation and seismic parameter extraction, by the implementation of digital processing methods at seismic observatories worldwide. It must be ensured that this new information will be available to the entire seismological community. It is believed that this purpose is best served with an ISOP that promotes increased on-site processing at digital stations in Africa and elsewhere. Improvements in seismology require truly international cooperation and the educational aspects of seismological practice form one of the goals of the ISOP. Thus, workshops will be needed in Africa to train analysts in ISOP procedures and to introduce them to modern techniques and applications of the data. Participants will, thus, benefit from theoretical results and practical experience that are of direct

  19. International Ultraviolet Explorer

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This report is the November 6, 1996 - October 9, 1997, IUE Final Report for the International Ultraviolet Explorer Final Archive contract. The ultimate objective of this contract is the completion of the archival reprocessing of all IUE data obtained at GSFC between 1978 and 1995.

  20. International Summer Programs.

    ERIC Educational Resources Information Center

    Cox, June

    1979-01-01

    The article describes five summer programs for gifted and talented students offered internationally. The programs outlined are workshops in the publication arts, a study of humanistic development; computer science, writing, and photography workshops; a language study; a historical/social study of English history; and a workshop on photography,…

  1. Simulation in International Studies

    ERIC Educational Resources Information Center

    Boyer, Mark A.

    2011-01-01

    Social scientists have long worked to replicate real-world phenomena in their research and teaching environments. Unlike our biophysical science colleagues, we are faced with an area of study that is not governed by the laws of physics and other more predictable relationships. As a result, social scientists, and international studies scholars more…

  2. International Student Profile.

    ERIC Educational Resources Information Center

    Baldwin, Anne

    In an effort to augment the information needed for decisions regarding policy, funding, programs, and services, Miami-Dade Community College (M-DCC) conducts periodic studies of its foreign student population. This report profiles international students at M-DCC for closing fall term 1990-91, and provides national data comparisons among…

  3. Requirements for Xenon International

    SciTech Connect

    Hayes, James C.; Ely, James H.; Haas, Derek A.; Harper, Warren W.; Heimbigner, Tom R.; Hubbard, Charles W.; Humble, Paul H.; Madison, Jill C.; Morris, Scott J.; Panisko, Mark E.; Ripplinger, Mike D.; Stewart, Timothy L.

    2015-12-30

    This document defines the requirements for the new Xenon International radioxenon system. The output of this project will be a Pacific Northwest National Laboratory (PNNL) developed prototype and a manufacturer-developed production prototype. The two prototypes are intended to be as close to matching as possible; this will be facilitated by overlapping development cycles and open communication between PNNL and the manufacturer.

  4. Introduction to International Trade.

    ERIC Educational Resources Information Center

    Crummett, Dan M.; Crummett, Jerrie

    This set of student and teacher guides is intended for use in a course to prepare students for entry-level employment in such occupational areas in international trade as business/finance, communications, logistics, and marketing. The following topics are covered in the course's five instructional units: introduction to careers in international…

  5. Internal Leadership Development.

    ERIC Educational Resources Information Center

    Thurber, Christopher A.

    2001-01-01

    Discusses how camps can cultivate staff from among the camper ranks. Outlines questions to consider in deciding whether internal leadership development (ILD) is appropriate and feasible. Describes elements of successful ILD programs and six training techniques to maximize ILD: leadership by example, delegation of responsibility, role-playing,…

  6. International waste management conference

    SciTech Connect

    Not Available

    1989-01-01

    This book contains the proceedings of the international waste management conference. Topics covered include: Quality assurance in the OCR WM program; Leading the spirit of quality; Dept. of Energy hazardous waste remedial actions program; management of hazardous waste projects; and System management and quality assurance.

  7. The International System.

    ERIC Educational Resources Information Center

    East, Maurice A.

    Designed as a unit for an international relations course, this systems approach paper outlines a learning method which contributes to the student's awareness that the United States is only one of many actors in the world. It also makes the student aware that there are limitations on the U. S. individual actions because of this interdependence and…

  8. Fall 2013 International Comparisons

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2014

    2014-01-01

    This Fall report is an aggregated statistical analysis of Measures of Academic Progress® (MAP®) data from international schools. The report provides a consistent means of comparisons of specific sub-groups by subject and grade, which allows partners to compare their MAP® results with other schools within their region or membership organization.…

  9. Internal displacement in Burma.

    PubMed

    Lanjouw, S; Mortimer, G; Bamforth, V

    2000-09-01

    The internal displacement of populations in Burma is not a new phenomenon. Displacement is caused by numerous factors. Not all of it is due to outright violence, but much is a consequence of misguided social and economic development initiatives. Efforts to consolidate the state by assimilating populations in government-controlled areas by military authorities on the one hand, while brokering cease-fires with non-state actors on the other, has uprooted civilian populations throughout the country. Very few areas in which internally displaced persons (IDPs) are found are not facing social turmoil within a climate of impunity. Humanitarian access to IDP populations remains extremely problematic. While relatively little information has been collected, assistance has been focused on targeting accessible groups. International concern within Burma has couched the problems of displacement within general development modalities, while international attention along its borders has sought to contain displacement. With the exception of several recent initiatives, few approaches have gone beyond assistance and engaged in the prevention or protection of the displaced.

  10. International HRD Perspectives.

    ERIC Educational Resources Information Center

    1997

    This document contains three papers from a symposium on international perspectives on human resource development (HRD). The first paper, "Human Resource Development Practices in American and Chinese High-technology Companies in Taiwan" (Hsin-yi Chen), uses quantitative and qualitative data on HRD practices in high-technology companies in the…

  11. Requirements for Xenon International

    SciTech Connect

    Hayes, James C.; Ely, James H.

    2013-09-26

    This document defines the requirements for the new Xenon International radioxenon system. The output of this project will be a Pacific Northwest National Laboratory (PNNL) developed prototype and a manufacturer-developed production prototype. The two prototypes are intended to be as close to matching as possible; this will be facilitated by overlapping development cycles and open communication between PNNL and the manufacturer.

  12. International. [SITE 2001 Section].

    ERIC Educational Resources Information Center

    Willis, Dee Anna, Ed.

    This document contains the following papers on international issues from the SITE (Society for Information Technology & Teacher Education) 2001 conference: (1) "Attitudes of Malaysian Vocational Trainee Teachers towards the Integration of Computer in Teaching" (Ab. Rahim Bakar and Shamsiah Mohamed); (2) "Views from an Asian Bridge: How…

  13. International Study Tour Groups

    ERIC Educational Resources Information Center

    O'Reilly, Frances L.; Matt, John J.; McCaw, William P.; Kero, Patty; Stewart, Courtney; Haddouch, Reda

    2014-01-01

    Using the context of international study tour groups, this study examined the personal and professional transformation that occurred among host faculty and staff at The University of Montana-Missoula as a result of their interactions with traveling academics from other countries. Data were collected from participant responses (n = 27) using a…

  14. International petroleum statistics report

    SciTech Connect

    1997-05-01

    The International Petroleum Statistics Report is a monthly publication that provides current international oil data. This report is published for the use of Members of Congress, Federal agencies, State agencies, industry, and the general public. Publication of this report is in keeping with responsibilities given the Energy Information Administration in Public Law 95-91. The International Petroleum Statistics Report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1995; OECD stocks from 1973 through 1995; and OECD trade from 1985 through 1995.

  15. International Space University

    NASA Technical Reports Server (NTRS)

    Kassler, Maggie (Editor)

    1993-01-01

    The International Space University (ISU) is described in this video, hosted by Marina Sirtis from the 'Star Trek' television show's Starship Enterprise. A complete explanation of what ISU is, how the university functions, and the benefits that the university provides are described. Included are brief comments from former ISU graduates.

  16. International energy outlook 1996

    SciTech Connect

    1996-05-01

    This International Energy Outlook presents historical data from 1970 to 1993 and EIA`s projections of energy consumption and carbon emissions through 2015 for 6 country groups. Prospects for individual fuels are discussed. Summary tables of the IEO96 world energy consumption, oil production, and carbon emissions projections are provided in Appendix A. The reference case projections of total foreign energy consumption and of natural gas, coal, and renewable energy were prepared using EIA`s World Energy Projection System (WEPS) model. Reference case projections of foreign oil production and consumption were prepared using the International Energy Module of the National Energy Modeling System (NEMS). Nuclear consumption projections were derived from the International Nuclear Model, PC Version (PC-INM). Alternatively, nuclear capacity projections were developed using two methods: the lower reference case projections were based on analysts` knowledge of the nuclear programs in different countries; the upper reference case was generated by the World Integrated Nuclear Evaluation System (WINES)--a demand-driven model. In addition, the NEMS Coal Export Submodule (CES) was used to derive flows in international coal trade. As noted above, foreign projections of electricity demand are now projected as part of the WEPS. 64 figs., 62 tabs.

  17. Internal split field generator

    DOEpatents

    Thundat; ,Thomas George; Van Neste, Charles W.; Vass, Arpad Alexander

    2012-01-03

    A generator includes a coil of conductive material. A stationary magnetic field source applies a stationary magnetic field to the coil. An internal magnetic field source is disposed within a cavity of the coil to apply a moving magnetic field to the coil. The stationary magnetic field interacts with the moving magnetic field to generate an electrical energy in the coil.

  18. ETV International Brief

    EPA Science Inventory

    The U.S. ETV Program has been active internationally for more than 10 years. Initially these efforts focused on sharing information about the U.S. program. Over the last four years, ETV has formalized working relationships with other countries with the objective of developing a...

  19. Requiem for Cultural Internationalism.

    ERIC Educational Resources Information Center

    Ninkovich, Frank

    1986-01-01

    Reviews Mary Brown Bullock's 1980 book,"An American Transplant: The Rockefeller Foundation and Peking Union Medical College." Far more than a narrow, scholarly history, this book is a case study of the far-reaching cultural impact of international educational exchange efforts. (JDH)

  20. Independence of Internal Auditors.

    ERIC Educational Resources Information Center

    Montondon, Lucille; Meixner, Wilda F.

    1993-01-01

    A survey of 288 college and university auditors investigated patterns in their appointment, reporting, and supervisory practices as indicators of independence and objectivity. Results indicate a weakness in the positioning of internal auditing within institutions, possibly compromising auditor independence. Because the auditing function is…

  1. International Air Transport Policy

    NASA Technical Reports Server (NTRS)

    Butler, C.

    1972-01-01

    The actions of the Civil Aviation Board in providing assistance and advice to the State Department regarding international air transport policy are discussed. The policies and guidelines of the Civil Aviation Board are defined. The relationship with the policies of the Executive Branch of the Government and the interpretations of the Department of Transportation are reported.

  2. International reference ionosphere 1990

    NASA Technical Reports Server (NTRS)

    Bilitza, Dieter; Rawer, K.; Bossy, L.; Kutiev, I.; Oyama, K.-I.; Leitinger, R.; Kazimirovsky, E.

    1990-01-01

    The International Reference Ionosphere 1990 (IRI-90) is described. IRI described monthly averages of the electron density, electron temperature, ion temperature, and ion composition in the altitude range from 50 to 1000 km for magnetically quiet conditions in the non-auroral ionosphere. The most important improvements and new developments are summarized.

  3. Merit Pay International

    ERIC Educational Resources Information Center

    Woessmann, Ludger

    2011-01-01

    American 15-year-olds continue to perform no better than at the industrial-world average in reading and science, and below that in mathematics. According to the results of the 2009 Program for International Student Assessment (PISA) tests, released in December 2010 by the Organisation for Economic Co-operation and Development (OECD), the United…

  4. International Perspectives on Evaluation

    ERIC Educational Resources Information Center

    Schwandt, Thomas A.

    2013-01-01

    Over the past year, the Board of Directors of the American Evaluation Association (AEA) has been discussing ways in which AEA can strengthen its relationships and build collaborative partnerships within the international evaluation community as well as increase AEA members' awareness of and capacity to engage issues that shape evaluation…

  5. Spring 2013 International Comparisons

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2013

    2013-01-01

    This report is an aggregated statistical analysis of Measures of Academic Progress® (MAP®) data from international schools. The report provides a consistent means of comparisons of specific sub-groups by subject and grade, which allows partners to compare their MAP® results with other schools within their region or membership organization. There…

  6. Internal combustion engine

    SciTech Connect

    Beaudsin, N.

    1984-05-22

    An internal combustion engine wherein the rod connecting the piston to the crankshaft has an enlarged portion defining a track which a crankshaft element cooperatingly engages; the track is topologically shaped so that the effect exerted by the crankshaft element on the connecting rod is reduced and/or cancelled for a given travel distance of the crankshaft element in the track.

  7. International Activities of ASE

    ERIC Educational Resources Information Center

    Symonds, Lynne; Jackson, Graham

    2013-01-01

    The Association for Science Education (ASE) has been involved in exchanges with various countries in a number of ways. Teachers from all over the world visit the Annual Conference and their own associations have often used ASE methods in developing their own programmes. The responsibilities of the International Committee of ASE range from…

  8. FFA International Programs.

    ERIC Educational Resources Information Center

    Future Farmers of America, Washington, DC.

    The document provides a list of 10 of the international agriculture activities available for the Future Farmers of America (FFA) chapters' participation: Work Experience Abroad (WEA); Development Projects; FFA Study Seminars; Care, Inc.; Walk for Development; Agriculutural Seminars; Heifer Project; CROP; World Neighbors; and Meals for Millions.…

  9. Internalism, Externalism and Coding

    ERIC Educational Resources Information Center

    Carr, Philip

    2007-01-01

    I examine some of the issues connected with the internalist/externalist distinction in work on the ontology of language. I note that Chomskyan radical internalism necessarily leads to a passive conception of child language acquisition. I reject that passive conception, and support current versions of constructivism [Tomasello, M., 2001. "The…

  10. Technology in International Admissions

    ERIC Educational Resources Information Center

    White, Elizabeth

    2012-01-01

    In a relatively short time, technology applications have become an essential feature of the admissions business. They make the jobs of international admissions professionals easier in many ways, allowing for more robust communication with applicants and counselors, a streamlined application process, and quicker access to information about…

  11. GNU debugger internal architecture

    SciTech Connect

    Miller, P.; Nessett, D.; Pizzi, R.

    1993-12-16

    This document describes the internal and architecture and implementation of the GNU debugger, gdb. Topics include inferior process management, command execution, symbol table management and remote debugging. Call graphs for specific functions are supplied. This document is not a complete description but offers a developer an overview which is the place to start before modification.

  12. Intel International Interim Report

    ERIC Educational Resources Information Center

    Martin, Wendy; Mandinach, Ellen; Kanaya, Tomoe; Culp, Katie McMillan

    2004-01-01

    This interim report presents preliminary data and observations from evaluations of Intel Teach to the Future being conducted around the world, and recommendations for building and refining this evaluation portfolio to ensure that findings will be instructive at the local, national and international level. The data presented here reflect the…

  13. Occupational Standards: International Perspectives.

    ERIC Educational Resources Information Center

    Oliveira, Joao, Ed.

    These nine papers from a conference of the International Research Network for Training and Development focus on occupational classification, standards, and certification. "Introduction" (Joao Oliveria) presents synopses with highlights from the papers. Part I offers an overview of recent developments in the United States in "Occupational Standards…

  14. International energy indicators. [International and US statistics

    SciTech Connect

    Bauer, E.K.

    1980-03-01

    For the international sector, a table of data is first presented followed by corresponding graph of the data for the following: (1) Iran: crude oil capacity, production, and shut-in, 1974 to February 1980; (2) Saudi Arabia (same as Iran); (3) OPEC (ex-Iran and Saudi Arabia); capacity, production, and shut-in, 1974 to January 1980; (4) non-OPEC Free World and US production of crude oil, 1973 to January 1980; (5) oil stocks: Free World, US, Japan, and Europe (landed), 1973 to 1979; (6) petroleum consumption by industrial countries, 1973 to October 1979; (7) USSR crude oil production, 1974 to February 1980; (8) Free World and US nuclear generation capacity, 1973 to January 1980. For the United States, the same data format is used for the following: (a) US imports of crude oil and products 1973 to January 1980; (b) landed cost of Saudi Arabia crude oil in current and 1974 dollars, 1974 to October 1979; (c) US trade in coal, 1973 to 1979; (d) summary of US merchandise trade, 1976 to January 1980; and (e) US energy/GNP ratio (in 1972 dollars), 1947 to 1979.

  15. Cognitive Enhancement and Education

    ERIC Educational Resources Information Center

    Buchanan, Allen

    2011-01-01

    Cognitive enhancement--augmenting normal cognitive capacities--is not new. Literacy, numeracy, computers, and the practices of science are all cognitive enhancements. Science is now making new cognitive enhancements possible. Biomedical cognitive enhancements (BCEs) include the administration of drugs, implants of genetically engineered or…

  16. Internal audit consider the implications.

    PubMed

    Baumgartner, Grant D; Hamilton, Angela

    2004-06-01

    Internal audit can not only allay external and internal concerns about appropriateness of business operations, but also help improve efficiency and the bottom line. To get an internal audit function under way, healthcare organizations need to obtain board buy-in, form an audit committee of the board, determine resources needed, perform a risk assessment, and develop an internal audit plan.

  17. Internal Auditing for School Districts.

    ERIC Educational Resources Information Center

    Cuzzetto, Charles

    This book provides guidelines for conducting internal audits of school districts. The first five chapters provide an overview of internal auditing and describe techniques that can be used to improve or implement internal audits in school districts. They offer information on the definition and benefits of internal auditing, the role of internal…

  18. Internal waves in the Petacalco canyon, Mexico

    NASA Astrophysics Data System (ADS)

    Ruiz-Angulo, Angel; Zavala-Hidalgo, Jorge

    2012-11-01

    On the Mexican coastline, specifically on the Pacific side, there are many submarine canyons. One of the key rolls of coastal submarine canyons is that deep water from adjacent oceanic regions is brought up to the shelf with lots of nutrients enhancing primary production. The head of the Petacalco canyon is located in the Petacalco Bay, in the Pacific Ocean (ca. 17.5N and 102W). During, previous CTD surveys in the area, strong upwelling has been noticed, based on those observations a later survey was designed covering the Petacalco canyon with much larger spatial resolution. Along with those measurements, two thermistor arrays were deployed on the SW crest of the canyon at depths of approximately 60 [m]. The observations, from the thermistor arrays, show large temporal temperature variations with a semi-diurnal frequency. Those variations suggest the presence of internal waves traveling along the canyon axis, if the incidence angle of the internal wave matches the topographic slope results on breaking of internal waves enhancing mixing. This condition occurs at several locations along the canyon axis producing enough mixing of deep oceanic waters with continental waters, increasing the abundance of nutrients in the surrounding region.

  19. Teacher Enhancement Institute

    NASA Technical Reports Server (NTRS)

    Marshall-Bradley, Tina

    1994-01-01

    During the 1980's, a period of intense concern over educational quality in the United States, few indicators of U.S. student achievement garnered the interest of policy makers and pundits as successfully as the results of international testing in mathematics and science. This concern was so great that as a part of the Goals 2000 initiative, President George Bush indicated that 'By the year 2000, U.S. students should be first in the world in mathematics and science.' The Clinton Administration is placing a major emphasis, not only on rigorous academic standards and creating a new system for assessing students' progress, but also including professional development as a major focus. The argument being that teachers need more sustained, intensive training to prepare them to teach to higher standards. Executive order 12821 mandates that national laboratories 'assist in the mathematics and science education of our Nation's students, teachers, parents and the public by establishing programs at their agency to provide for training elementary and secondary school teachers to improve their knowledge of mathematics and science'. These and other issues led to the development of ideas for a project that addresses the need for excellence in mathematics, science and technology instruction. In response to these initiatives the NASA/LaRC Teacher Enhancement Institute was proposed. The TEI incorporated systemic reform perspectives, enhanced content knowledge for teachers, and teacher preparation. Emphasis was also placed on recruiting those educators who teach in impoverished urban school districts with at-risk student populations who have been traditionally under represented in science, mathematics, technology and engineering. Participants in the Teacher Enhancement Institute were 37 teachers from grades K-8, teaching in Region 2 in the state of Virginia, as well as 2 preservice teachers from Norfolk State University and one teacher from Dublin, Virginia, where a Science

  20. Myalgic encephalomyelitis: International Consensus Criteria

    PubMed Central

    Carruthers, B M; van de Sande, M I; De Meirleir, K L; Klimas, N G; Broderick, G; Mitchell, T; Staines, D; Powles, A C P; Speight, N; Vallings, R; Bateman, L; Baumgarten-Austrheim, B; Bell, D S; Carlo-Stella, N; Chia, J; Darragh, A; Jo, D; Lewis, D; Light, A R; Marshall-Gradisbik, S; Mena, I; Mikovits, J A; Miwa, K; Murovska, M; Pall, M L; Stevens, S

    2011-01-01

    , Japan; A. Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia; Department of Biochemistry & Basic Medical Sciences, Washington State University, Portland, OR; Department of Sports Sciences, University of the Pacific, Stockton, CA USA). Myalgic encephalomyelitis: International Consensus Criteria (Review). J Intern Med 2011; 270: 327–338. The label ‘chronic fatigue syndrome’ (CFS) has persisted for many years because of the lack of knowledge of the aetiological agents and the disease process. In view of more recent research and clinical experience that strongly point to widespread inflammation and multisystemic neuropathology, it is more appropriate and correct to use the term ‘myalgic encephalomyelitis’ (ME) because it indicates an underlying pathophysiology. It is also consistent with the neurological classification of ME in the World Health Organization’s International Classification of Diseases (ICD G93.3). Consequently, an International Consensus Panel consisting of clinicians, researchers, teaching faculty and an independent patient advocate was formed with the purpose of developing criteria based on current knowledge. Thirteen countries and a wide range of specialties were represented. Collectively, members have approximately 400 years of both clinical and teaching experience, authored hundreds of peer-reviewed publications, diagnosed or treated approximately 50 000 patients with ME, and several members coauthored previous criteria. The expertise and experience of the panel members as well as PubMed and other medical sources were utilized in a progression of suggestions/drafts/reviews/revisions. The authors, free of any sponsoring organization, achieved 100% consensus through a Delphi-type process. The scope of this paper is limited to criteria of ME and their application. Accordingly, the criteria reflect the complex symptomatology. Operational notes enhance clarity and specificity by providing guidance in the

  1. [International accreditation of medical school towards quality assurance of medical education].

    PubMed

    Yoshioka, Toshimasa; Nara, Nobuo

    2013-01-01

    An internationalization of practical medicine evoked international migrations of medical professionals. Since basic medical education is different among countries, the internationalization required international quality assurance of medical education. Global trend moves toward establishment of international accreditation system based on international standards. The World Federation for Medical Education proposed Global Standards for Quality Improvement as the international standards. Medical schools in Japan have started to establish program evaluation system. The standards which incorporated international standards have been published. The system for accreditation is being considered. An accreditation body, Japan Accreditation Council for Medical Education, is under construction. The accreditation is expected to enhance quality of education in Japan. PMID:24291905

  2. International Spotlight: Israel

    ERIC Educational Resources Information Center

    Glicksman, Allen; Litwin, Howard

    2011-01-01

    The State of Israel provides significant opportunities to study social processes that can enhance our understanding of the aging experience. It has high life expectancy and rapid growth of its older population. With an older cohort that is composed largely of former immigrants and includes a minority Arab population, Israel provides much diversity…

  3. Euthanasia and international human rights law: prolegomena for an international debate.

    PubMed

    Van den Akker, B; Janssens, R M; Ten Have, H A

    1997-10-01

    In this paper we examine in what respects international human rights law can provide a basis for the establishment of an international debate on euthanasia. Such a debate seems imperative, as in many countries euthanasia is considered taboo in the context of medical practice, yet at the same time, supposedly, decisions are taken to intentionally shorten patients' lives. In the Netherlands, the act of euthanasia will not lead to the prosecution of the physician involved if the physician has complied with certain procedures. The Dutch debate centres on procedures marginalizing important moral aspects of euthanasia. An international debate, addressing the fundamental morality of euthanasia and of other medical decisions involving the end of life, will eventually enhance medical practice in the Netherlands as well as in other countries.

  4. The international petrochemical industry

    SciTech Connect

    Chapman, K.

    1991-01-01

    The petrochemical industry occupies a crucial place in economic, strategic and political terms in the twentieth century. The author explains its growth and international distribution from the 1920s tot he present, relating the particular experience of petrochemicals to the processes that have shaped the long-term evolution of industry in general. The geographical coverage of this book extends from the regional to international scale, and its historical scope embraces one hundred years from the laboratory origins of polymer science and petrochemistry to the massive operations of modern industry. It represents the result of twenty years of research, and reflects the author's privileged access to company sources in both the U.S. and Europe.

  5. Internal core tightener

    DOEpatents

    Brynsvold, Glen V.; Snyder, Jr., Harold J.

    1976-06-22

    An internal core tightener which is a linear actuated (vertical actuation motion) expanding device utilizing a minimum of moving parts to perform the lateral tightening function. The key features are: (1) large contact areas to transmit loads during reactor operation; (2) actuation cam surfaces loaded only during clamping and unclamping operation; (3) separation of the parts and internal operation involved in the holding function from those involved in the actuation function; and (4) preloaded pads with compliant travel at each face of the hexagonal assembly at the two clamping planes to accommodate thermal expansion and irradiation induced swelling. The latter feature enables use of a "fixed" outer core boundary, and thus eliminates the uncertainty in gross core dimensions, and potential for rapid core reactivity changes as a result of core dimensional change.

  6. First International Microgravity Laboratory

    NASA Astrophysics Data System (ADS)

    McMahan, Tracy; Shea, Charlotte; Wiginton, Margaret; Neal, Valerie; Gately, Michele; Hunt, Lila; Graben, Jean; Tiderman, Julie; Accardi, Denise

    This colorful booklet presents capsule information on every aspect of the International Microgravity Laboratory (IML). As part of Spacelab, IML is divided into Life Science Experiments and Materials Science Experiments. Because the life and materials sciences use different Spacelab resources, they are logically paired on the IML missions. Life science investigations generally require significant crew involvement, and crew members often participate as test subjects or operators. Materials missions capitalize on these complementary experiments. International cooperation consists in participation by the European Space Agency, Canada, France, Germany, and Japan who are all partners in developing hardware and experiments of IML missions. IML experiments are crucial to future space ventures, like the development of Space Station Freedom, the establishment of lunar colonies, and the exploration of other planets. Principal investigators are identified for each experiment.

  7. First International Microgravity Laboratory

    NASA Technical Reports Server (NTRS)

    Mcmahan, Tracy; Shea, Charlotte; Wiginton, Margaret; Neal, Valerie; Gately, Michele; Hunt, Lila; Graben, Jean; Tiderman, Julie; Accardi, Denise

    1990-01-01

    This colorful booklet presents capsule information on every aspect of the International Microgravity Laboratory (IML). As part of Spacelab, IML is divided into Life Science Experiments and Materials Science Experiments. Because the life and materials sciences use different Spacelab resources, they are logically paired on the IML missions. Life science investigations generally require significant crew involvement, and crew members often participate as test subjects or operators. Materials missions capitalize on these complementary experiments. International cooperation consists in participation by the European Space Agency, Canada, France, Germany, and Japan who are all partners in developing hardware and experiments of IML missions. IML experiments are crucial to future space ventures, like the development of Space Station Freedom, the establishment of lunar colonies, and the exploration of other planets. Principal investigators are identified for each experiment.

  8. [Vaccination for international travelers].

    PubMed

    Arrazola, M Pilar; Serrano, Almudena; López-Vélez, Rogelio

    2016-05-01

    Traveler's vaccination is one of the key strategies for the prevention of infectious diseases during international travel. The risk of acquiring an infectious disease is determined in each case by the characteristics of the traveler and the travel, so the pre-departure medical advice of the traveler must be individualized. The World Health Organization classifies travelerś vaccines into three groups. - Vaccines for routine use in national immunization programs: Haemophilus influenzae type b, hepatitis B, polio, measles-mumps-rubella, tetanus-diphtheria-whooping a cough, and chickenpox. - Vaccinations required by law in certain countries before to enter them: yellow fever, meningococcal disease and poliomyelitis. - Vaccines recommended depending on the circumstances: cholera, japanese encephalitis, tick-borne encephalitis, meningococcal disease, typhoid fever, influenza, hepatitis A, hepatitis B, rabies and BCG. This review is intended to introduce the reader to the field of international vaccination.

  9. Frontiers in Internal Medicine.

    PubMed

    Lopez-Jimenez, F; Luna-Jimenez, M A; Polanczyk, C A; Rohde, L E; Rivera-Moscoso, R; Reza-Albarran, A A; Macias-Hernandez, A E; Obrador, G T; Levey, A S; Mora, R

    1997-01-01

    Clinical research in Internal Medicine has provided many scientific advances during the past few years. However, the newly generated information overrides the time available to read all of the medical literature regarding advances in Internal Medicine. The goal of this review is to summarize some of the most relevant improvements in clinical practice published over the last few years. From Cardiology to Pulmonology, the authors of this review expose in a succinct way what they and many of their peers consider to be the most transcendental information gathered from thousands of publications. The authors of this review article have attempted to avoid sensationalism by including facts instead of just simply optimistic preliminary findings that can mislead clinicians' decision making. The review is focused on information obtained through well-designed, prospective clinical trials and cohorts where the effectiveness of medical interventions and diagnostic procedures were tested. PMID:9428570

  10. International Water Center

    NASA Astrophysics Data System (ADS)

    The urban district of Nancy and the Town of Nancy, France, have taken the initiative of creating an International Center of Water (Centre International de l'Eau à Nancy—NAN.C.I.E.) in association with two universities, six engineering colleges, the Research Centers of Nancy, the Rhine-Meuse Basin Agency, and the Chamber of Commerce and Industry. The aim of this center is to promote research and technology transfer in the areas of water and sanitation. In 1985 it will initiate a research program drawing on the experience of 350 researchers and engineers of various disciplines who have already been assigned to research in these fields. The research themes, the majority of which will be multidisciplinary, concern aspects of hygiene and health, the engineering of industrial processes, water resources, and the environment and agriculture. A specialist training program offering five types of training aimed at university graduates, graduates of engineering colleges, or experts, will start in October 1984.

  11. International Nuclear Security

    SciTech Connect

    Doyle, James E.

    2012-08-14

    This presentation discusses: (1) Definitions of international nuclear security; (2) What degree of security do we have now; (3) Limitations of a nuclear security strategy focused on national lock-downs of fissile materials and weapons; (4) What do current trends say about the future; and (5) How can nuclear security be strengthened? Nuclear security can be strengthened by: (1) More accurate baseline inventories; (2) Better physical protection, control and accounting; (3) Effective personnel reliability programs; (4) Minimize weapons-usable materials and consolidate to fewer locations; (5) Consider local threat environment when siting facilities; (6) Implement pledges made in the NSS process; and (7) More robust interdiction, emergency response and special operations capabilities. International cooperation is desirable, but not always possible.

  12. International energy outlook, 1992

    SciTech Connect

    Not Available

    1992-04-08

    This report presents the current Energy Information Administration (EIA) assessment of the long-term outlook for international energy markets. The historic political and economic changes occurring in Easter Europe and the former Soviet Union will, no doubt, transform regional markets and world trade. This report pays particular attention to energy markets and resources in those countries that were once a part of the Centrally Planned Economies (CPE's) and how prospective changes in these countries might influence the energy outlook for the rest of the world. Several major EIA estimates determine, in large part, the resulting energy projections presented here. These include estimates of the energy intensity of economic activity; oil and natural gas production capacities; nuclear and hydroelectric generation capacities; international coal trade; and the rate of incremental energy requirements met by alternatives to oil.

  13. International energy outlook, 1992

    SciTech Connect

    Not Available

    1992-04-08

    This report presents the current Energy Information Administration (EIA) assessment of the long-term outlook for international energy markets. The historic political and economic changes occurring in Easter Europe and the former Soviet Union will, no doubt, transform regional markets and world trade. This report pays particular attention to energy markets and resources in those countries that were once a part of the Centrally Planned Economies (CPE`s) and how prospective changes in these countries might influence the energy outlook for the rest of the world. Several major EIA estimates determine, in large part, the resulting energy projections presented here. These include estimates of the energy intensity of economic activity; oil and natural gas production capacities; nuclear and hydroelectric generation capacities; international coal trade; and the rate of incremental energy requirements met by alternatives to oil.

  14. [Vaccination for international travelers].

    PubMed

    Arrazola, M Pilar; Serrano, Almudena; López-Vélez, Rogelio

    2016-05-01

    Traveler's vaccination is one of the key strategies for the prevention of infectious diseases during international travel. The risk of acquiring an infectious disease is determined in each case by the characteristics of the traveler and the travel, so the pre-departure medical advice of the traveler must be individualized. The World Health Organization classifies travelerś vaccines into three groups. - Vaccines for routine use in national immunization programs: Haemophilus influenzae type b, hepatitis B, polio, measles-mumps-rubella, tetanus-diphtheria-whooping a cough, and chickenpox. - Vaccinations required by law in certain countries before to enter them: yellow fever, meningococcal disease and poliomyelitis. - Vaccines recommended depending on the circumstances: cholera, japanese encephalitis, tick-borne encephalitis, meningococcal disease, typhoid fever, influenza, hepatitis A, hepatitis B, rabies and BCG. This review is intended to introduce the reader to the field of international vaccination. PMID:26920587

  15. Genetic discrimination: international perspectives.

    PubMed

    Otlowski, M; Taylor, S; Bombard, Y

    2012-01-01

    Genetic discrimination (GD) is a complex, multifaceted ethical, psychosocial, and legal phenomenon. It is defined as the differential treatment of asymptomatic individuals or their relatives on the basis of their real or assumed genetic characteristics. This article presents an overview of GD within the contemporary international context. It describes the concept of GD and its contextual features, reviews research evidence regarding people's experiences of GD and the impact of GD within a range of domains, and provides an overview of legal and policy responses to GD that have emerged globally. We argue that GD is a significant and internationally established phenomenon that requires multilevel responses to ensure social justice and equitable outcomes for all citizens. Future research should monitor GD and its impacts within the community as well as institutions and should evaluate the effectiveness of legislative, policy, community education, and systemic responses. PMID:22607273

  16. Space-time framework of internal measurement

    NASA Astrophysics Data System (ADS)

    Matsuno, Koichiro

    1998-07-01

    Measurement internal to material bodies is ubiquitous. The internal observer has its own local space-time framework that enables the observer to distinguish, even to a slightest degree, those material bodies fallen into that framework. Internal measurement proceeding among the internal observers come to negotiate a construction of more encompassing local framework of space and time. The construction takes place through friction among the internal observers. Emergent phenomena are related to an occurrence of enlarging the local space-time framework through the frictional negotiation among the material participants serving as the internal observers. Unless such a negotiation is obtained, the internal observers would have to move around in the local space-time frameworks of their own that are mutually incommensurable. Enhancement of material organization as demonstrated in biological evolutionary processes manifests an inexhaustible negotiation for enlarging the local space-time framework available to the internal observers. In contrast, Newtonian space-time framework, that remains absolute and all encompassing, is an asymptote at which no further emergent phenomena could be expected. It is thus ironical to expect something to emerge within the framework of Newtonian absolute space and time. Instead of being a complex and organized configuration of interaction to appear within the global space-time framework, emergent phenomena are a consequence of negotiation among the local space-time frameworks available to internal measurement. Most indicative of the negotiation of local space-time frameworks is emergence of a conscious self grounding upon the reflexive nature of perceptions, that is, a self-consciousness in short, that certainly goes beyond the Kantian transcendental subject. Accordingly, a synthetic discourse on securing consciousness upon the ground of self-consciousness can be developed, though linguistic exposition of consciousness upon self

  17. International markets for CCTs

    SciTech Connect

    Ferriter, J.P.

    1997-12-31

    The paper begins by describing the role of the International Energy Agency, the importance of coal, what the IEA is doing in the area of clean coal technology, and the role of the IEA Coal Industry Advisory Board. The paper then discusses which coal technologies will be chosen, what the problem areas are, and what can be done to accelerate the take-up of clean coal technologies.

  18. INTERNATIONAL ENGLISH MANUAL

    SciTech Connect

    AMADOR, MABLE; KELLER, YVONNE KELLER

    2002-02-22

    This document presents a set of guidelines for authors who wish to express themselves more clearly to foreign readers, or readers whose first language is not American English. Topics include idioms, technical terms, jargon, word meaning, acronyms, and international conventions of measurement. The guidelines will help writers of technical documents present their ideas more effectively to audiences that may include individuals whose first language is not American English, including audiences with individuals from other English-speaking countries.

  19. International petroleum statistics report

    SciTech Connect

    Not Available

    1995-01-01

    This monthly publication provides current data on international oil production, demand, imports, exports, and stocks. Section 1 contains time series data on world oil production, and on oil demand and stocks in the OECD. Section 2 presents an oil supply/demand balance for the world. Section 3 presents data on oil imports by OECD countries. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries.

  20. Internal Waves, Indian Ocean

    NASA Technical Reports Server (NTRS)

    1990-01-01

    This photograph, taken in sunglint conditions, captures open ocean internal waves which are diffracting around shoals south of the Seychelle islands (4.5S, 55.5E) and recombining to form interference patterns. The clouds to the north of the waves cover two of the Seychelle islands: Silhouette and Mahe. Mahe is the main island of the archipelago. The small rocky island surrounded by reef around which the waves diffract is Platte Island.

  1. International petroleum statistics report

    SciTech Connect

    Not Available

    1994-06-01

    This report presents data on international oil production, demand, imports, exports, and stocks. Section 1 contains time series data on world oil production, and on oil demand and stocks in the OECD. Section 2 presents an oil supply/demand balance for the world, presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. Section 4 presents annual time series data on world oil production, oil stocks, demand, and trade in OECD countries.

  2. International petroleum statistics report

    SciTech Connect

    1997-11-01

    This document is a monthly publication which provides current data on international oil production,demand,imports and stocks. This report has four sections which contain time series data on world oil production and oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). Also included is oil supply/demand balance information for the world, and data on oil imports and trade by OECD countries.

  3. The International Halley Watch

    NASA Technical Reports Server (NTRS)

    1980-01-01

    In preparation for the 1985 to 1986 apparition of Halley's Comet, the International Halley Watch (IHW) has initiated a comprehensive program to simulate, encourage, and coordinate scientific observation of the apparition. The observing groups with which the IHW plans to interact are discussed and the ground based observing nets are described in detail. An outline of the history of observations of Halley's Comet and a synopsis of comet properties and physics are included.

  4. International Seismological Centre

    USGS Publications Warehouse

    Spall, H.; Hughes, A.

    1979-01-01

    The International Seismological Centre had its origins when the British seismologist Professor John Milne returned to England from Japan in 1895 to retire at Shide on the Isle of Eight. In cooperation with the British Association for the Advancement of Science, Milne had set up a number of seismographic stations around the world and, while Tokyo, had published a Catalogue of 8,33 Earthquakes Recorded in Japan, 1885-1892. 

  5. The International Lunar Network

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.

    2008-01-01

    A new lunar science flight projects line has been introduced within NASA s Science Mission Directorate's (SMDs) proposed 2009 budget, including two new robotic missions designed to accomplish key scientific objectives and, when possible, provide results useful to the Exploration Systems Mission Directorate (ESMD) and the Space Operations Mission Directorate (SOMD) as those organizations grapple with the challenges of returning humans to the Moon. The first mission in this line will be the Lunar Reconnaissance Orbiter, an ESMD mission that will acquire key information for human return to the moon activities, which will transition after one year of operations to the SMD Lunar Science Program for a 2-year nominal science mission. The second mission, the Lunar Atmosphere and Dust Environment Explorer (LADEE) will be launch in 2011 along with the GRAIL Discovery mission to the moon. The third is delivery of two landed payloads as part of the International Lunar Network (ILN). This flight projects line provides a robust robotic lunar science program for the next 8 years and beyond, complements SMD s initiatives to build a robust lunar science community through R&A lines, and increases international participation in NASA s robotic exploration plans. The International Lunar Network is envisioned as a global lunar geophysical network, which fulfills many of the stated recommendations of the recent National Research Council report on The Scientific Context for Exploration of the Moon [2], but is difficult for any single space agency to accomplish on its own. The ILN would provide the necessary global coverage by involving US and international landed missions as individual nodes working together. Ultimately, this network could comprise 8-10 or more nodes operating simultaneously, while minimizing the required contribution from each space agency. Indian, Russian, Japanese, and British landed missions are currently being formulated and SMD is actively seeking partnership with

  6. Polarized internal target apparatus

    DOEpatents

    Holt, Roy J.

    1986-01-01

    A polarized internal target apparatus with a polarized gas target of improved polarization and density achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms.

  7. Polarized internal target apparatus

    DOEpatents

    Holt, R.J.

    1984-10-10

    A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

  8. Project: Internal communications

    NASA Technical Reports Server (NTRS)

    Black, Lydia

    1994-01-01

    The purpose of this study was to ascertain the perceived information needs of NASA Langley employees. One hundred and twelve face-to-face interviews were conducted with a representative sample of aero-space technologists, administrative professionals, technicians. and secretarial/clerical personnel. Results of employee perceptions are analyzed and summarized using affinity diagramming. Particular strategies to maximize use of existing internal communication networks are discussed.

  9. Internationally educated health professionals.

    PubMed

    Leatt, Peggy

    2010-01-01

    Even as recently as a decade ago, it was not uncommon for many Canadian decision- and policy makers in healthcare and government to ignore the matter of internationally educated healthcare professional (IEHP) integration and retention. With all the talk in the past few years, however, of employee shortages in nearly every healthcare profession and a rapidly aging population that requires more and more care, nobody can afford to neglect this potentially large and highly skilled talent pool. PMID:20523134

  10. International petroleum statistics report

    SciTech Connect

    1997-07-01

    The International Petroleum Statistics Report is a monthly publication that provides current international data. The report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent 12 months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1996; OECD stocks from 1973 through 1996; and OECD trade from 1986 through 1996.

  11. International Convergence on Geoscience Cyberinfrastructure

    NASA Astrophysics Data System (ADS)

    Allison, M. L.; Atkinson, R.; Arctur, D. K.; Cox, S.; Jackson, I.; Nativi, S.; Wyborn, L. A.

    2012-04-01

    There is growing international consensus on addressing the challenges to cyber(e)-infrastructure for the geosciences. These challenges include: Creating common standards and protocols; Engaging the vast number of distributed data resources; Establishing practices for recognition of and respect for intellectual property; Developing simple data and resource discovery and access systems; Building mechanisms to encourage development of web service tools and workflows for data analysis; Brokering the diverse disciplinary service buses; Creating sustainable business models for maintenance and evolution of information resources; Integrating the data management life-cycle into the practice of science. Efforts around the world are converging towards de facto creation of an integrated global digital data network for the geosciences based on common standards and protocols for data discovery and access, and a shared vision of distributed, web-based, open source interoperable data access and integration. Commonalities include use of Open Geospatial Consortium (OGC) and ISO specifications and standardized data interchange mechanisms. For multidisciplinarity, mediation, adaptation, and profiling services have been successfully introduced to leverage the geosciences standards which are commonly used by the different geoscience communities -introducing a brokering approach which extends the basic SOA archetype. Principal challenges are less technical than cultural, social, and organizational. Before we can make data interoperable, we must make people interoperable. These challenges are being met by increased coordination of development activities (technical, organizational, social) among leaders and practitioners in national and international efforts across the geosciences to foster commonalities across disparate networks. In doing so, we will 1) leverage and share resources, and developments, 2) facilitate and enhance emerging technical and structural advances, 3) promote

  12. ASTER satellite observations for international disaster management

    USGS Publications Warehouse

    Duda, K.A.; Abrams, M.

    2012-01-01

    When lives are threatened or lost due to catastrophic disasters, and when massive financial impacts are experienced, international emergency response teams rapidly mobilize to provide urgently required support. Satellite observations of affected areas often provide essential insight into the magnitude and details of the impacts. The large cost and high complexity of developing and operating satellite flight and ground systems encourages international collaboration in acquiring imagery for such significant global events in order to speed delivery of critical information to help those affected, and optimize spectral, spatial, and temporal coverage of the areas of interest. The International Charter-Space and Major Disasters was established to enable such collaboration in sensor tasking during times of crisis and is often activated in response to calls for assistance from authorized users. Insight is provided from a U.S. perspective into sensor support for Charter activations and other disaster events through a description of the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), which has been used to support emergency situations for over a decade through its expedited tasking and near real-time data delivery capabilities. Examples of successes achieved and challenges encountered in international collaboration to develop related systems and fulfill tasking requests suggest operational considerations for new missions as well as areas for future enhancements.

  13. Evolution of Internal Waves in Monterey Bay

    NASA Astrophysics Data System (ADS)

    Jachec, S. M.; Fringer, O. B.; Gerritsen, M.; Street, R. L.

    2004-12-01

    Recently, it has been hypothesized (e.g., Munk and Wunsch, and Briscoe and Muller) that internal waves propagating near coastal boundaries may play an important role in the global budgets of mixing and dissipation. Lien and Gregg, and Gregg and colleagues cite that highly-concentrated intermittent patches of turbulence and enhanced dissipation exist over ridges and within canyons; this is consistent with internal wave findings by Petruncio and with ideas from Garrett and Munk who suggest that instability and internal wave breaking are likely mechanisms for mixing through turbulence. According to Hickey as much as 50% of the world's coastal ocean may be composed of canyons, ridges, and gullies. Therefore, exists a need to understand the interaction between complex bathymetry and internal waves. One such location is Monterey Bay, CA, a location known to possess a well-defined submarine canyon, internal waves, and elevated dissipation. Although field experiments, such as the Internal Tide EXperiments (ITEX), and prior numerical simulations of Monterey Bay by Petruncio, Rosenfeld, and Paduan from the Naval Postgraduate School, and scientists from other universities have expanded the knowledge of the interaction between internal waves and bathymetry, the evolution of the internal wave field under realistic physical conditions and over complex bathymetry is not fully understood. Some shortcomings of their simulations were summarized by Rosenfeld and others; improvements suggested include nonhydrostatic simulations, and finer grid resolution. These suggestions seem reasonable because high frequency processes are present; these processes include canyon bores, solitons, and possibly breaking internal waves. The purpose of this work is to describe the evolution of an internal wave field under realistic physical conditions and over a representative portion of the Monterey Bay's complex bathymetry. This is accomplished by use of the Stanford Unstructured Nonhydrostatic Terrain

  14. Astronomy education activities for the international community

    NASA Astrophysics Data System (ADS)

    Laatsch, S.

    In today s world technology allows students from around the globe to interact and share learning experiences in a variety of subjects Astronomy by its nature as a science and cultural phenomena lends itself to a variety of educational activities that can be shared across borders and cultures While teaching astronomy at East Carolina University and working with the International Planetarium Society a program is being piloted to link students in grades 3 and 6 from the United States and India to study phases of the Moon This project is in its early stages but will enhance students understanding of a basic astronomical concept while sharing cultural ideas regarding our nearest neighbor in space The International Planetarium Society has a number of educational programs and opportunities for astronomy and space science educators around the globe A variety of programs and opportunities will be discussed

  15. Two phase exhaust for internal combustion engine

    SciTech Connect

    Vuk, Carl T.

    2011-11-29

    An internal combustion engine having a reciprocating multi cylinder internal combustion engine with multiple valves. At least a pair of exhaust valves are provided and each supply a separate power extraction device. The first exhaust valves connect to a power turbine used to provide additional power to the engine either mechanically or electrically. The flow path from these exhaust valves is smaller in area and volume than a second flow path which is used to deliver products of combustion to a turbocharger turbine. The timing of the exhaust valve events is controlled to produce a higher grade of energy to the power turbine and enhance the ability to extract power from the combustion process.

  16. Enhancement and Civic Virtue

    PubMed Central

    Jefferson, Will; Douglas, Thomas; Kahane, Guy; Savulescu, Julian

    2014-01-01

    Opponents of biomedical enhancement frequently adopt what Allen Buchanan has called the Personal Goods Assumption. On this assumption, the benefits of biomedical enhancement will accrue primarily to those individuals who undergo enhancements, not to wider society. Buchanan has argued that biomedical enhancements might in fact have substantial social benefits by increasing productivity. We outline another way in which enhancements might benefit wider society: by augmenting civic virtue and thus improving the functioning of our political communities. We thus directly confront critics of biomedical enhancement who argue that it will lead to a loss of social cohesion and a breakdown in political life. PMID:24882886

  17. How rotational vortices enhance transfers

    NASA Astrophysics Data System (ADS)

    Griffani, D.; Rognon, P.; Metzger, B.; Einav, I.

    2013-09-01

    Inspired by recent observations of granular flow, we examine how rotational vortices contribute to heat or mass transfer enhancement in a fluid. We use a tracer method to simulate both diffusion and advection in systems of differing intrinsic diffusivities D0, vortex sizes R, vortex rotation frequencies f, and vortex lifetimes ℓ. The results reveal that these systems exhibit an effective diffusive behavior, characterized by an effective diffusivity Deff. A striking finding is the existence of two regimes, dichotomised by the Péclet number Pe = R2f/D0. When the Péclet number is less than one, there is no transfer enhancement, Deff = D0. For higher values, vortices produce some transfer enhancement with a corresponding power law Deff/D0 ≈ Pen. The power n ranges from a lower bound of 0.5 for stationary vortices of lifetime infinity, to an upper bound of 1 for vortices of lifetimes shorter than half a rotation. This difference is attributed to two different internal mechanisms involving the coupling of diffusion and advection. These results could provide new insights on the transfer properties of fluid systems comprising rotational vortices, such as granular materials, suspensions, foams, and emulsions, as well as low Reynolds number stirred flows.

  18. [Lower is better: ENHANCE affair].

    PubMed

    Scardi, Sabino; Umari, Paolo; D'Agata, Bianca Maria

    2008-06-01

    Ezetimibe lowers the intestinal absorption of cholesterol, being complementary to the effects of statin. To check its efficacy in lowering the carotid intima-media thickness, in 2002 a multicenter international trial called ENHANCE was started, in order to assess by ultrasound the regression of atherosclerotic plaques. The protocol tested the use of simvastatin 80 mg + placebo versus simvastatin 80 mg + ezetimibe 10 mg in 720 randomized patients. Both drugs were well tolerated. Combination therapy was associated with a larger reduction in LDL cholesterol, but there were no differences in the intima-media thickness measured at three sites in the carotid arteries, nor differences in cardiovascular events between the two groups in the trial. These results provoked disappointment of sponsors (Merck, Schering Plough) who, although the results of the trial were available since march 2007, delayed official communication of about 18 months. This led to speculations and rumors among media, American Government, cardiologic scientific associations, and consequences in the Ezetimibe market and at Wall Street. In particular, the American College of Cardiology didn't accept the communication of ENHANCE results to the Late Breaking Trial Session of the Chicago congress, diverting it to another secondary forum. In conclusion, the experience of the ENHANCE trial suggests to pharmaceutical companies, researchers, clinicians, scientific companies and media a deep meditation in order to avoid in the future similar problems in the management of results of medical research.

  19. English as an International Language: International Student and Identity Formation

    ERIC Educational Resources Information Center

    Ha, Phan Le

    2009-01-01

    Drawing on the literature on Asian international students, current debates surrounding English as an international language (EIL), and the conceptual tools of appropriation, this article reports the findings of a qualitative research study with eight Asian international students studying at a university in Thailand to explore their taking…

  20. Chemical penetration enhancers.

    PubMed

    Newton, Stephen J

    2013-01-01

    Chemical penetration enhancers are utilized in topical preparations as a method for enhancing permeation of drugs across the skin. In particular, they are utilized for transdermal delivery of medications in an attempt to produce a systemic response, to avoid first-pass metabolism, and to decrease the gastrointestinal transit time observed with oral medications. A review of the selection of chemical penetration enhancers, their mechanism of action, the most common chemical penetration enhancers in each class, and alternatives will be discussed in detail.

  1. INTERNAL REPAIR OF PIPELINES

    SciTech Connect

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; Nancy Porter; Mike Sullivan; Chris Neary

    2004-04-12

    The two broad categories of deposited weld metal repair and fiber-reinforced composite liner repair technologies were reviewed for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Preliminary test programs were developed for both deposited weld metal repair and for fiber-reinforced composite liner repair. Evaluation trials have been conducted using a modified fiber-reinforced composite liner provided by RolaTube and pipe sections without liners. All pipe section specimens failed in areas of simulated damage. Pipe sections containing fiber-reinforced composite liners failed at pressures marginally greater than the pipe sections without liners. The next step is to evaluate a liner material with a modulus of elasticity approximately 95% of the modulus of elasticity for steel. Preliminary welding parameters were developed for deposited weld metal repair in preparation of the receipt of Pacific Gas & Electric's internal pipeline welding repair system (that was designed specifically for 559 mm (22 in.) diameter pipe) and the receipt of 559 mm (22 in.) pipe sections from Panhandle Eastern. The next steps are to transfer welding parameters to the PG&E system and to pressure test repaired pipe sections to failure. A survey of pipeline operators was conducted to better understand the needs and performance requirements of the natural gas transmission industry regarding internal repair. Completed surveys contained the following principal conclusions: (1) Use of internal weld repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling (HDD) when a new bore must be created to

  2. Internal absorber solar collector

    DOEpatents

    Sletten, Carlyle J.; Herskovitz, Sheldon B.; Holt, F. S.; Sletten, E. J.

    1981-01-01

    Thin solar collecting panels are described made from arrays of small rod collectors consisting of a refracting dielectric rod lens with an absorber imbedded within it and a reflecting mirror coated on the back side of the dielectric rod. Non-tracking collector panels on vertical walls or roof tops receive approximately 90% of solar radiation within an acceptance zone 60.degree. in elevation angle by 120.degree. or more in the azimuth sectors with a collector concentration ratio of approximately 3.0. Miniaturized construction of the circular dielectric rods with internal absorbers reduces the weight per area of glass, plastic and metal used in the collector panels. No external parts or insulation are needed as heat losses are low due to partial vacuum or low conductivity gas surrounding heated portions of the collector. The miniature internal absorbers are generally made of solid copper with black selective surface and the collected solar heat is extracted at the collector ends by thermal conductivity along the absorber rods. Heat is removed from end fittings by use of liquid circulants. Several alternate constructions are provided for simplifying collector panel fabrication and for preventing the thermal expansion and contraction of the heated absorber or circulant tubes from damaging vacuum seals. In a modified version of the internal absorber collector, oil with temperature dependent viscosity is pumped through a segmented absorber which is now composed of closely spaced insulated metal tubes. In this way the circulant is automatically diverted through heated portions of the absorber giving higher collector concentration ratios than theoretically possible for an unsegmented absorber.

  3. Internal combustion engine

    SciTech Connect

    Evans, H.G.; Speer, S.

    1991-12-31

    This patent describes improvement in a 2-cycle, diesel cycle internal combustion engine comprising a single in-line engine block, internal wall surfaces defining at least one cylinder within the engine block, the central longitudinal axis of each cylinder being within a common plane extending longitudinally of the engine block, the axially extending internal wall surface of each cylinder being closed at one end and having at least one air intake port therethrough, a piston axially and reciprocally movable within each cylinder over a permitted stroke distance, so as to alternately cover and expose each air intake port for a finite time period; an exhaust port at the closed end of the cylinder above the piston, and a mechanically operated valve for opening and closing such exhaust port located immediately adjacent such port, a substantially rigid connecting rod pivotably connected at one end of each piston, and a crankshaft, rotatably connected to the second end of each connecting rod, such that the crankshaft is caused to rotate connecting means between the piston and the connecting rod. The improvement comprises the diameter of the cylinder is greater than the permitted stroke distance of the piston within the cylinder, and the axis of the crankshaft is parallel to and laterally offset from the common plane by a distance sufficient to form an angle alpha between the connecting rod and the axis of the cylinder, when the piston is at top-dead center, of at least about 12 degrees, such that the time during which each air intake port is exposed is increased when the direction of crankshaft rotation is opposite to the direction of the crankshaft offset from the common plane.

  4. Threats to international science

    NASA Astrophysics Data System (ADS)

    Kisslinger, Carl

    The role of nongovernmental organizations (NGOs) as effective agents for promoting world science is seriously threatened. It is ironic that the threat comes from Norway and Denmark, two countries that have demonstrated a deep commitment to individual freedom and human rights. Motivated by a sincere desire to express their strongest disapproval of the “apartheid” policies of the government of the Republic of South Africa, these countries have passed laws that have the effect of rejecting the International Council of Scientific Unions (ICSU) principles of nondiscrimination and free circulation of scientists.

  5. Linearly Adjustable International Portfolios

    NASA Astrophysics Data System (ADS)

    Fonseca, R. J.; Kuhn, D.; Rustem, B.

    2010-09-01

    We present an approach to multi-stage international portfolio optimization based on the imposition of a linear structure on the recourse decisions. Multiperiod decision problems are traditionally formulated as stochastic programs. Scenario tree based solutions however can become intractable as the number of stages increases. By restricting the space of decision policies to linear rules, we obtain a conservative tractable approximation to the original problem. Local asset prices and foreign exchange rates are modelled separately, which allows for a direct measure of their impact on the final portfolio value.

  6. International energy annual, 1993

    SciTech Connect

    1995-05-08

    This document presents an overview of key international energy trends for production, consumption, imports, and exports of primary energy commodities in over 200 countries, dependencies, and areas of special sovereignty. Also included are population and gross domestic product data, as well as prices for crude oil and petroleum products in selected countries. Renewable energy includes hydroelectric, geothermal, solar and wind electric power and alcohol for fuel. The data were largely derived from published sources and reports from US Embassy personnel in foreign posts. EIA also used data from reputable secondary sources, industry reports, etc.

  7. International petroleum statistics report

    SciTech Connect

    1998-01-01

    This monthly publication provides international oil data for January 1998. The report presents data on oil production, demand, imports, and stocks in four sections. Section 1 containes time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. section 3 presents data on oil imports by OECD countries. Section 4 containes annual time series data on world oil production and oil stocks, demand, and trade in OECD countries.

  8. International energy annual 1995

    SciTech Connect

    1996-12-01

    The International Energy Annual presents information and trends on world energy production and consumption for petroleum, natural gas, coal, and electricity. Production and consumption data are reported in standard units as well as British thermal units (Btu). Trade and reserves are shown for petroleum, natural gas, and coal. Data are provided on crude oil refining capacity and electricity installed capacity by type. Prices are included for selected crude oils and for refined petroleum products in selected countries. Population and Gross Domestic Product data are also provided.

  9. International data base.

    PubMed

    Quick, S

    1984-12-01

    The concept of the International Data Base (IDB) grew from recognition of the need for timely, high quality information on the demographic, social and economic characteristics of foreign countries. During the past 2 decades, the Bureau of the Census, US Department of Commerce, has been compiling, analyzing and evaluating international demographic data and, to a lesser extent, socioeconomic data with particular emphasis on developing countries. In 1979, at the request of the Office of Women in Development at the Agency for International Development, a computerized data base of demographic and socioeconomic statistics that could be used to assess the status of women in developing countries was established. The major categories of data now being included in IDB are as follows: population by age and sex; vital rates, infant mortality and life tables; health and nutrition; fertility and child survivorship; migration; provinces and cities; family planning; ethnic, religious and language groups; literacy and education; labor force, employment, income and gross national product; and household size and housing indicators. The Bureau, through its Center for International Reserch (CIR), developed a computerized central depository of demographic, social and economic data for all countries of the world to serve the needs of the public and private sectors. The initial emphasis was on demographic and social data, since these subject areas are those for which a vast amount of data has already been compiled, analyzed and evaluated by CIR staff. However, meetings are being planned with users to determine the additional types of data that are desired, particularly in the economic and health-related areas. IDB includes data for all countries of the world, by urban and rural residence. The time coverage is from 1950 to the present. Data sources include: population and industrial censuses and surveys, administrative records, population registers, statistical publications, research

  10. Internal insulation system development

    NASA Technical Reports Server (NTRS)

    Gille, J. P.

    1973-01-01

    The development of an internal insulation system for cryogenic liquids is described. The insulation system is based on a gas layer concept in which capillary or surface tension effects are used to maintain a stable gas layer within a cellular core structure between the tank wall and the contained cryogen. In this work, a 1.8 meter diameter tank was insulated and tested with liquid hydrogen. Ability to withstand cycling of the aluminum tank wall to 450 K was a design and test condition.

  11. Factors Affecting Internal Blast

    NASA Astrophysics Data System (ADS)

    Granholm, R. H.; Sandusky, H. W.; Felts, J. E.

    2007-12-01

    Internal blast refers to explosion effects in confined spaces, which are dominated by the heat output of the explosive. Theoretical temperatures and pressures may not be reached due to heat losses and incomplete gas mixing. Gas mixing can have the largest effect, potentially reducing peak quasi-static pressure by a factor of two due to lack of thermal equilibrium between products and atmosphere in the space, separate from the effect of incomplete combustion of excess fuel when that atmosphere is air. Chamber and test geometry affect gas mixing, which has been inferred through temperature and pressure measurements and compared to calculations. Late-time combustion is observed for TNT compared to HMX.

  12. International Space Station

    NASA Technical Reports Server (NTRS)

    Wahlberg, Jennifer; Gordon, Randy

    2010-01-01

    This slide presentation reviews the research on the International Space Station (ISS), including the sponsorship of payloads by country and within NASA. Included is a description of the space available for research, the Laboratory "Rack" facilities, the external research facilities and those available from the Japanese Experiment Module (i.e., Kibo), and highlights the investigations that JAXA has maintained. There is also a review of the launch vehicles and spacecraft that are available for payload transportation to the ISS, including cargo capabilities of the spacecraft.

  13. Decentralization Calls for Internal Audits.

    ERIC Educational Resources Information Center

    DiCello, Jim

    1995-01-01

    Outlines internal-auditing strategies necessitated by decentralization. Describes the following areas of concern: the student activities account, student attendance, and funding delegated to the site level. Guidelines for conducting an internal audit are also included. (LMI)

  14. Learning Activities for International Business.

    ERIC Educational Resources Information Center

    Haynes, Thomas

    1998-01-01

    The National Standards for Business Education include nine areas relating to international business: awareness, communication, environmental factors, ethics, finance, management, marketing, import/export, and organizational structure of international business. (SK)

  15. INTERNATIONAL LAW: HINDRANCE OR HELP?

    EPA Science Inventory

    As international Remote Sensing/Geographic Information Systems (RS/GIS)
    organizations develop, legal issues are becoming an important factor in promoting or limiting international cooperation. We must keep legal considerations in mind during the creation, implementation, and ...

  16. Goddard Summer Interns: Danielle Wood

    NASA Video Gallery

    Profile of Goddard intern Danielle Wood. Danielle is interning at Goddard in the Innovative Partnerships Program and at NASA Headquarters in the Office of the Chief Technologist in the summer of 20...

  17. Editor's Shelf: International Juvenile Titles.

    ERIC Educational Resources Information Center

    Mitchell-Powell, Brenda

    1994-01-01

    Provides an annotated list of international juvenile picture books and notes those that emphasize text over pictures. The 49 titles present international perspectives for educators, librarians, and parents seeking materials with alternative cultural content. The majority are folk tales. (SLD)

  18. SETI and International Radio Law

    NASA Astrophysics Data System (ADS)

    Lyall, F.

    2010-04-01

    The use of radio in SETI is subject to international rules agreed through the International Telecommunication Union. These are summarised. An opportunity for their revision will arise in 2012. Suggestions may be made.

  19. Reflections on international medical law.

    PubMed

    Wattad, Mohammed S; Hrevtsova, Radmyla Yu

    2011-12-01

    Does international medical law exist, in the first place, as an independent area of study? If so, is it urgently required in an era of comparative studies? Namely, to what extent, if at all, international studies differ from comparative ones? Besides, what are the particular characteristics of such international discipline? Namely, what are the particular features of this field that elaborate on our legal and scientific understanding in sketching possible definition for this notion of "international medical law?" In addition, how does international medical law correlate with health, ethics and health policies in our globalized world? And finally, what are the challenges that might face the international community, once the concept of "international medical law" is acknowledged? This papers aims at establishing the conceptual grounds for these questions, thus calling for the acknowledgment of a new field of study described as "international medical law".

  20. CCD Sparse Field CTE Internal

    NASA Astrophysics Data System (ADS)

    Hernandez, Svea

    2012-10-01

    CTE measurements are made using the "internal sparse field test", along the parallelaxis. The "POS=" optional parameter, introduced during cycle 11, is used to provideoff-center MSM positioning of some slits. All exposures are internals.

  1. CCD Sparse Field CTE Internal

    NASA Astrophysics Data System (ADS)

    Wolfe, Michael

    2011-10-01

    CTE measurements are made using the "internal sparse field test", along the parallelaxis. The "POS=" optional parameter, introduced during cycle 11, is used to provideoff-center MSM positionings of some slits. All exposures are internals.

  2. CCD Sparse Field CTE Internal

    NASA Astrophysics Data System (ADS)

    Wolfe, Michael

    2010-09-01

    CTE measurements are made using the "internal sparse field test", along the parallelaxis. The "POS=" optional parameter, introduced during cycle 11, is used to provideoff-center MSM positionings of some slits. All exposures are internals.

  3. CCD Sparse Field CTE Internal

    NASA Astrophysics Data System (ADS)

    Hernandez, Svea

    2013-10-01

    CTE measurements are made using the "internal sparse field test", along the parallelaxis. The "POS=" optional parameter, introduced during cycle 11, is used to provideoff-center MSM positioning of some slits. All exposures are internals.

  4. CCD Sparse Field CTE Internal

    NASA Astrophysics Data System (ADS)

    Wolfe, Michael

    2009-07-01

    CTE measurements are made using the "internal sparse field test", along the parallelaxis. The "POS=" optional parameter, introduced during cycle 11, is used to provideoff-center MSM positionings of some slits. All exposures are internals.

  5. Joining Forces: The Case of Alliant International University

    ERIC Educational Resources Information Center

    Leslie, Heather

    2013-01-01

    Mergers and acquisitions are a prevalent force in higher education as more colleges and universities are joining forces to expand resources, enhance missions, or prevent closures. This study examines the merger of Alliant University (formerly California School of Professional Psychology) with United States International University to create what…

  6. Space Biosciences, Space-X, and the International Space Station

    NASA Technical Reports Server (NTRS)

    Wigley, Cecilia

    2014-01-01

    Space Biosciences Research on the International Space Station uses living organisms to study a variety of research questions. To enhance our understanding of fundamental biological processes. To develop the fundations for a safe, productive human exploration of space. To improve the quality of life on earth.

  7. Higher Education Institutions: Satisfaction and Loyalty among International Students

    ERIC Educational Resources Information Center

    Paswan, Audhesh K.; Ganesh, Gopala

    2009-01-01

    This study empirically investigates the relationship between satisfaction with educational service augmenters and consumer loyalty within the context of the international student market. An enhanced state of consumer satisfaction, also labeled as delight, is captured by focusing on service augmenters that fall outside the domain of the core…

  8. International Education Programs: Access to the World and Its Languages

    ERIC Educational Resources Information Center

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The International Education Programs Service (IEPS) administers 14 education programs. These programs are complementary in nature and designed to benefit a variety of audiences through training programs, research, start-up or enhancement projects, and fellowships. This paper provides brief descriptions of these programs.

  9. Hanford internal dosimetry program manual

    SciTech Connect

    Carbaugh, E.H.; Sula, M.J.; Bihl, D.E.; Aldridge, T.L.

    1989-10-01

    This document describes the Hanford Internal Dosimetry program. Program Services include administrating the bioassay monitoring program, evaluating and documenting assessments of internal exposure and dose, ensuring that analytical laboratories conform to requirements, selecting and applying appropriate models and procedures for evaluating internal radionuclide deposition and the resulting dose, and technically guiding and supporting Hanford contractors in matters regarding internal dosimetry. 13 refs., 16 figs., 42 tabs.

  10. International Cooperation in Distance Education.

    ERIC Educational Resources Information Center

    John, Magnus

    This paper addresses some of the general issues of international cooperation within the context of distance education. Examples of the types of international cooperation are introduced in order to explain some of the pitfalls that can occur when coordinating organizations on an international level. Extensive discussion is undertaken concerning…

  11. Simulation in International Relations Education.

    ERIC Educational Resources Information Center

    Starkey, Brigid A.; Blake, Elizabeth L.

    2001-01-01

    Discusses the educational implications of simulations in international relations. Highlights include the development of international relations simulations; the role of technology; the International Communication and Negotiation Simulations (ICONS) project at the University of Maryland; evolving information technology; and simulating real-world…

  12. The Internal-Candidate Syndrome

    ERIC Educational Resources Information Center

    Barden, Dennis M.

    2008-01-01

    In this article, the author explains the complications involved when an internal candidate is included in an open search for a leadership position in an academic institution. Internal-candidate syndrome is a dilemma faced by institutions when they have to choose between an internal candidate and an external one. There are two reasons why…

  13. Affect Control in International Interactions

    ERIC Educational Resources Information Center

    Heise, David R.; Lerner, Steven J.

    2006-01-01

    This research tests the proposition that national leaders generate international interactions in the process of maintaining sentiments about nations and international actions. The analysis deals with 1,934 international incidents in which one of 25 Middle Eastern nations responded twice within four weeks to an instigation by another of the 25…

  14. (International meeting of ecology)

    SciTech Connect

    Bowman, K.O.

    1990-09-14

    This report, dated September 14, 1990, covers the trip to Japan of Dr. Kimiko O. Bowman, Senior Research Member in the Mathematical Sciences Section. Engineering Physics and Mathematics Division, Oak Ridge National Laboratory. The trip was supported by the Center for Indoor Air Research (CIAR). The purpose of the trip was to attend and present an invited talk at the Fifth International Congress of Ecology held at the Yokohama Prince Hotel in Yokohama, Kanagawa Prefecture, Japan, August 23--30, 1990. The presented talk Testing the Mutagenicity of Components'' described two papers on research conducted under contract to the CIAR. The only other site visited was Tokyo Science University by invitation of Dr. T. Okuno,Provost of the University. The main activities consisted of attending the meeting, contributing to the discussion, and presenting an invited talk at the conference. The discussion with Dr. Okuno was on general biometric research topics. The main benefit was to gain greater international exposure for our work and to discover new applications for it.

  15. International petroleum statistics report

    SciTech Connect

    1996-05-01

    The International Petroleum Statistics Report presents data on international oil production, demand, imports, exports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1995; OECD stocks from 1973 through 1995; and OECD trade from 1084 through 1994.

  16. International petroleum statistics report

    SciTech Connect

    1995-11-01

    The International Petroleum Statistics Report presents data on international oil production, demand, imports, exports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1994; OECD stocks from 1973 through 1994; and OECD trade from 1984 through 1994.

  17. International petroleum statistics report

    SciTech Connect

    1995-07-27

    The International Petroleum Statistics Report presents data on international oil production, demand, imports, and exports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1994; OECD stocks from 1973 through 1994; and OECD trade from 1984 through 1994.

  18. Understanding Lustre Internals

    SciTech Connect

    Wang, Feiyi; Oral, H Sarp; Shipman, Galen M; Drokin, Oleg; Wang, Di; Huang, He

    2009-04-01

    Lustre was initiated and funded, almost a decade ago, by the U.S. Department of Energy (DoE) Office of Science and National Nuclear Security Administration laboratories to address the need for an open source, highly-scalable, high-performance parallel filesystem on by then present and future supercomputing platforms. Throughout the last decade, it was deployed over numerous medium-to-large-scale supercomputing platforms and clusters, and it performed and met the expectations of the Lustre user community. As it stands at the time of writing this document, according to the Top500 list, 15 of the top 30 supercomputers in the world use Lustre filesystem. This report aims to present a streamlined overview on how Lustre works internally at reasonable details including relevant data structures, APIs, protocols and algorithms involved for Lustre version 1.6 source code base. More importantly, it tries to explain how various components interconnect with each other and function as a system. Portions of this report are based on discussions with Oak Ridge National Laboratory Lustre Center of Excellence team members and portions of it are based on our own understanding of how the code works. We, as the authors team bare all responsibilities for all errors and omissions in this document. We can only hope it helps current and future Lustre users and Lustre code developers as much as it helped us understanding the Lustre source code and its internal workings.

  19. International petroleum statistics report

    SciTech Connect

    1996-10-01

    The International Petroleum Statistics Report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. Word oil production and OECD demand data are for the years 1970 through 1995; OECD stocks from 1973 through 1995; and OECD trade from 1985 through 1995.

  20. International energy outlook 1998

    SciTech Connect

    1998-04-01

    The International Energy Outlook 1998 (IEO98) presents an assessment by the Energy Information Administration (EIA) of the outlook for international energy markets through 2020. Projections in IEO98 are displaced according to six basic country groupings. The industrialized region includes projections for four individual countries -- the United States, Canada, Mexico, and Japan -- along with the subgroups Western Europe and Australasia (defined as Australia, New Zealand, and the US Territories). The developing countries are represented by four separate regional subgroups: developing Asia, Africa, Middle East, and Central and South America. China and India are represented in developing Asia. New to this year`s report, country-level projections are provided for Brazil -- which is represented in Central and South America. Eastern Europe and the former Soviet Union (EE/FSU) are considered as a separate country grouping. The report begins with a review of world trends in energy demand. Regional consumption projections for oil, natural gas, coal, nuclear power, and renewable energy (hydroelectricity, geothermal, wind, solar, and other renewables) are presented in five fuel chapters, with a review of the current status of each fuel on a worldwide basis. Summary tables of the IEO98 projections for world energy consumption, carbon emissions, oil production, and nuclear power generating capacity are provided in Appendix A. 88 figs., 77 tabs.

  1. International communications via satellite

    NASA Astrophysics Data System (ADS)

    McLucas, J. L.

    The evolution of communications satellite systems is traced in terms of technical capabilities and technological advances. The Communications Act of 1962 led to the establishment of INTELSAT on an international basis in 1964. The original 19 signatory nations has grown to over 100, and over 800 ground relay stations have been built. The INTELSAT system comprises spacecraft over the Atlantic, Pacific, and Indian Oceans and handles 2/3 of the world's international electronic communications and all transoceanic television. The 1965 Early Bird satellite had a 240 two-way telephone link capacity and weighed 38 kg, while the Intelsat V satellites, of which there will be nine, have increased the capacity to 20,000 voice circuits and Intelsat VI will double the number by 1993. Increasing demand for satellite communications links is driving the design and development of space platforms for multiple missions of communications, meteorological studies, and on-board switching and data processing in excess of current multiple satellite systems.

  2. [Vaccinations for international travelers].

    PubMed

    Berens-Riha, N; Alberer, M; Löscher, T

    2014-03-01

    Vaccinations are a prominent part of health preparations before international travel. They can avoid or significantly reduce the risk of numerous infectious diseases. Until recently, vaccination against yellow fever was the only obligatory vaccination. However, according to updated international health regulations, other vaccinations and prophylactic measures may be required at entry from certain countries. For all routine vaccinations as recommended in Germany, necessary revaccination and catch-up of missed vaccinations should be administered before travel. At most destinations the risk of infection is higher than in Germany. Hepatitis A vaccine is generally recommended for travelers to areas of increased risk, polio vaccine for all destinations where eradication is not yet confirmed (Asia and Africa). The indications for other travel vaccines must take into consideration travel destination and itinerary, type and duration of travel, individual risk of exposure as well as the epidemiology of the disease to be prevented. Several vaccines of potential interest for travel medicine, e.g., new vaccines against malaria and dengue fever, are under development.

  3. International Clean Energy Coalition

    SciTech Connect

    Erin Skootsky; Matt Gardner; Bevan Flansburgh

    2010-09-28

    In 2003, the National Association of Regulatory Utility Commissioners (NARUC) and National Energy Technology Laboratories (NETL) collaboratively established the International Clean Energy Coalition (ICEC). The coalition consisting of energy policy-makers, technologists, and financial institutions was designed to assist developing countries in forming and supporting local approaches to greenhouse gas mitigation within the energy sector. ICEC's work focused on capacity building and clean energy deployment in countries that rely heavily on fossil-based electric generation. Under ICEC, the coalition formed a steering committee consisting of NARUC members and held a series of meetings to develop and manage the workplan and define successful outcomes for the projects. ICEC identified India as a target country for their work and completed a country assessment that helped ICEC build a framework for discussion with Indian energy decisionmakers including two follow-on in-country workshops. As of the conclusion of the project in 2010, ICEC had also conducted outreach activities conducted during United Nations Framework Convention on Climate Change (UNFCCC) Ninth Conference of Parties (COP 9) and COP 10. The broad goal of this project was to develop a coalition of decision-makers, technologists, and financial institutions to assist developing countries in implementing affordable, effective and resource appropriate technology and policy strategies to mitigate greenhouse gas emissions. Project goals were met through international forums, a country assessment, and in-country workshops. This project focused on countries that rely heavily on fossil-based electric generation.

  4. Country watch: international.

    PubMed

    Dionne, P

    1998-01-01

    The International Tribunal for Children's Rights (ITCR) was established to conduct individual and public inquiries and propose concrete solutions to violations of children's rights. This article reports on the efforts of the ITCR to enforce extraterritorial laws in response to the international dimension of child sex exploitation. The primary message being advocated is that travelers cannot go to foreign countries to engage in sexual crimes against children, evade criminal prosecution in the countries where the crimes are committed and then expect to return home without any consequences. In its first public hearings held in Paris, France to the address the effectiveness of extraterritorial legislation, governments and nongovernmental organizations informed the ITCR about their attempts to halt child sexual exploitation. Several changes needed to make extraterritorial laws more effective were cited. These include public awareness-raising; supporting existing instruments; application of preventive approaches to child abuse; and sensitizing and motivating judicial, police and administrative authorities to provide for the needs to fight child sex tourism. PMID:12348687

  5. Modern International Research Groups: Networks and Infrastructure

    NASA Astrophysics Data System (ADS)

    Katehi, Linda

    2009-05-01

    In a globalized economy, education and research are becoming increasing international in content and context. Academic and research institutions worldwide try to internationalize their programs by setting formal or informal collaborations. An education that is enhanced by international experiences leads to mobility of the science and technology workforce. Existing academic cultures and research structures are at odds with efforts to internationalize education. For the past 20-30 years, the US has recognized the need to improve the abroad experience of our scientists and technologists: however progress has been slow. Despite a number of both federally and privately supported programs, efforts to scale up the numbers of participants have not been satisfactory. The exchange is imbalanced as more foreign scientists and researchers move to the US than the other way around. There are a number of issues that contribute to this imbalance but we could consider the US academic career system, as defined by its policies and practices, as a barrier to internationalizing the early career faculty experience. Strict curricula, pre-tenure policies and financial commitments discourage students, post doctoral fellows and pre-tenure faculty from taking international leaves to participate in research abroad experiences. Specifically, achieving an international experience requires funding that is not provided by the universities. Furthermore, intellectual property requirements and constraints in pre-tenure probationary periods may discourage students and faculty from collaborations with peers across the Atlantic or Pacific or across the American continent. Environments that support early career networking are not available. This presentation will discuss the increasing need for international collaborations and will explore the need for additional programs, more integration, better conditions and improved infrastructures that can encourage and support mobility of scientists. In addition

  6. INTERNAL REPAIR OF PIPELINES

    SciTech Connect

    Bill Bruce; Nancy Porter; George Ritter; Matt Boring; Mark Lozev; Ian Harris; Bill Mohr; Dennis Harwig; Robin Gordon; Chris Neary; Mike Sullivan

    2005-07-20

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without

  7. INTERNAL REPAIR OF PIPELINES

    SciTech Connect

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-08-17

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners

  8. INTERNAL REPAIR OF PIPELINES

    SciTech Connect

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-12-31

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without

  9. Microbial enhancement of oil recovery: Recent advances

    SciTech Connect

    Premuzic, E.T.; Woodhead, A.D.; Vivirito, K.J.

    1992-01-01

    During recent years, systematic, scientific, and engineering effort by researchers in the United States and abroad, has established the scientific basis for Microbial Enhanced Oil Recovery (MEOR) technology. The successful application of MEOR technology as an oil recovery process is a goal of the Department of Energy (DOE). Research efforts involving aspects of MEOR in the microbiological, biochemical, and engineering fields led DOE to sponsor an International Conference at Brookhaven National Laboratory in 1992, to facilitate the exchange of information and a discussion of ideas for the future research emphasis. At this, the Fourth International MEOR Conference, where international attendees from 12 countries presented a total of 35 papers, participants saw an equal distribution between research'' and field applications.'' In addition, several modeling and state-of-the-art'' presentations summed up the present status of MEOR science and engineering. Individual papers in this proceedings have been process separately for inclusion in the Energy Science and Technology Database.

  10. Control Techtronics International

    SciTech Connect

    West, J.

    1995-12-31

    Polish graded coal can be burned in existing stoker boilers and meet the 1998 Air Quality standard. This is accomplished with the Control Techtronics microprocessor-based combustion controller accurately and repeatedly: (a) matching the combustion air to the coal firing rate, with continuous stack sensor feedback; (b) continuously varying the boiler`s firing rate based on output water temperature or steam pressure; (c) continuously varying the exhaust fan`s speed to maintain minimum negative pressure in the boiler`s combustion chamber; and recirculating a portion of the flue gas, at varying amounts throughout the boiler`s firing rate. Systems for five boilers have been installed and are operating on MPEC`s Balicka plant in Krakow. Control Techtronics International has $10 million of U.S. Export-Import Bank funds available for similar projects throughout Poland.

  11. International energy indicators

    NASA Astrophysics Data System (ADS)

    Bauer, E. K.

    1981-02-01

    Extensive data are compiled for energy on the international scene and for the US. Data included are: world crude oil production, 1975 to date; Iran: crude oil capacity, production, and shut-in, 1974 to date; Saudi Arabia: crude oil capacity, production, and shut-in, 1974 to date; OPEC (Ex-Iran and Saudi Arabia): capacity, production, and shut-in, 1974 to date; oil stocks: Free World, US, Japan, and Europe (landed), 1973 to date; petroleum consumption by industrial countries, 1973 to date; USSR crude oil production, 1974 to date; Free World and US nuclear generation capacity, 1973 to date. Data are supplied specifically for the US on US gross imports of crude oil and products, 1973 to date; landed cost of Saudi crude in current and 1974 dollars; US trade in bituminous coal, 1973 to date; summary of US merchandise trade, 1976 to date; and energy/GNP ratio.

  12. Second International Lygus Symposium

    PubMed Central

    Goodell, P. B.; Ellsworth, Peter C.

    2008-01-01

    The Second International Lygus Symposium brought together 52 entomologists from six nations and 11 states representing universities, public agencies, and private entities to discuss the latest research on Lygus species and their relatives. Symposium topics included Lygus biology, behavior and ecology, IPM, insecticides and resistance, and biological control. Papers and posters dealt with Lygus as a pest of several crops, including cotton, strawberries, seed alfalfa, canola, dry beans, cucumbers, cereals, peaches, and new crops guayule and lesquerella. Intercrop movement of Lygus2008200820082008 species was another important topic of many presentations. In the capstone session, participants identified needs and priorities for ongoing Lygus research and education (available at http://ag.arizona.edu/apmc/Arid_SWPMC_RAMP.html). The conference was sponsored in part by FMC Corporation, the University of Arizona Arizona Pest Management Center, the University of California Statewide IPM Program, and a grant to Ellsworth et al. (CRIS# 0207436) from the USDA-CSREES, Risk Avoidance and Mitigation Program (RAMP).

  13. Aureolegraph internal scattering correction.

    PubMed

    DeVore, John; Villanucci, Dennis; LePage, Andrew

    2012-11-20

    Two methods of determining instrumental scattering for correcting aureolegraph measurements of particulate solar scattering are presented. One involves subtracting measurements made with and without an external occluding ball and the other is a modification of the Langley Plot method and involves extrapolating aureolegraph measurements collected through a large range of solar zenith angles. Examples of internal scattering correction determinations using the latter method show similar power-law dependencies on scattering, but vary by roughly a factor of 8 and suggest that changing aerosol conditions during the determinations render this method problematic. Examples of corrections of scattering profiles using the former method are presented for a range of atmospheric particulate layers from aerosols to cumulus and cirrus clouds.

  14. Aureolegraph internal scattering correction.

    PubMed

    DeVore, John; Villanucci, Dennis; LePage, Andrew

    2012-11-20

    Two methods of determining instrumental scattering for correcting aureolegraph measurements of particulate solar scattering are presented. One involves subtracting measurements made with and without an external occluding ball and the other is a modification of the Langley Plot method and involves extrapolating aureolegraph measurements collected through a large range of solar zenith angles. Examples of internal scattering correction determinations using the latter method show similar power-law dependencies on scattering, but vary by roughly a factor of 8 and suggest that changing aerosol conditions during the determinations render this method problematic. Examples of corrections of scattering profiles using the former method are presented for a range of atmospheric particulate layers from aerosols to cumulus and cirrus clouds. PMID:23207299

  15. International energy indicators

    NASA Astrophysics Data System (ADS)

    Rossi, E., Jr.

    1981-12-01

    Data on international energy indicators were tabulated and graphically represented. The following data are presented: world crude oil production, 1974 to October 1981; OPEC crude oil productive capacity; world crude oil and refined product inventory levels, 1975 to October, 1981; oil consumption in OECD countries, 1975 to October 1981; USSR crude oil production and exports, 1975 to October 1981; free world and US nuclear electricity generation, 1973 to December, 1981 and current capacity. Specific US data presented are: US domestic oil supply, 1977 to June, 1981; US gross imports of crude oil and products, 1973 to October, 1981; landed cost of Saudi crude current and 1974 dollars; US coal trade, 1975 to September, 1981; US natural gas trade, 1981; and energy/GNP ratio.

  16. Internal constitution of Mars.

    NASA Technical Reports Server (NTRS)

    Anderson, D. L.

    1972-01-01

    Models of the internal structure of Mars consistent with the mass, radius and moment of inertia of the planet are constructed. The models assume that the radius of the core is between 0.36 and 0.60 of the radius of the planet, that the zero-pressure density of the mantle is between 3.54 and 3.49 g/cu cm, and that the planet contains 25 to 28% iron. Meteorite models of Mars containing 25 wt % iron and 12 wt % core are also proposed. It is maintained that Mars in contrast to the earth is an incompletely differentiated planet with a core substantially richer in sulfur than the core of the earth. The absence of a magnetic field on Mars is possibly linked with lack of lunar precessional torque and the small size and high resistivity of the Martian core.

  17. Internationally Comparable Health Indices

    PubMed Central

    Meijer, Erik; Kapteyn, Arie; Andreyeva, Tatiana

    2013-01-01

    One of the most intractable problems in international health research is the lack of comparability of health measures across countries or cultures. We develop a cross-country measurement model for health in which functional limitations, self-reports of health, and a physical measure are interrelated to construct health indices. To establish comparability across countries, we define the measurement scales by the physical measure while other parameters vary by country to reflect cultural and linguistic differences in response patterns. We find significant cross-country variation in response styles of health reports along with variability in genuine health that is related to differences in national income. Our health indices achieve satisfactory reliability of about 80% and their gradients by age, income, and wealth for the most part show the expected patterns. Moreover, the health indices correlate much more strongly with income and net worth than self reported health measures. PMID:20572201

  18. INTERNATIONAL DECOMMISSIONING SYMPOSIUM 2000

    SciTech Connect

    M.A. Ebadian, Ph.D.

    2001-01-01

    The purpose of IDS 2000 was to deliver a world-class conference on applicable global environmental issues. The objective of this conference was to publicize environmental progress of individual countries, to provide a forum for technology developer and problem-holder interaction, to facilitate environmental and technology discussions between the commercial and financial communities, and to accommodate information and education exchange between governments, industries, universities, and scientists. The scope of this project included the planning and execution of an international conference on the decommissioning of nuclear facilities, and the providing of a business forum for vendors and participants sufficient to attract service providers, technology developers, and the business and financial communities. These groups, when working together with attendees from regulatory organizations and government decision-maker groups, provide an opportunity to more effectively and efficiently expedite the decommissioning projects.

  19. Chromosome 19 International Workshop

    SciTech Connect

    Pericak-Vance, M.A. . Medical Center); Ropers, H.H. . Dept. of Human Genetics); Carrano, A.J. )

    1993-01-04

    The Second International Workshop on Human Chromosome 19 was hosted on January 25 and 26, 1992, by the Department of Human Genetics, University Hospital Nijmegen, The Netherlands, at the 'Meerdal Conference Center'. The workshop was supported by a grant from the European Community obtained through HUGO, the Dutch Research Organization (NWO) and the Muscular Dystrophy Association (MDA). Travel support for American participants was provided by the Department of Energy. The goals of this workshop were to produce genetic, physical and integrated maps of chromosome 19, to identify inconsistencies and gaps, and to discuss and exchange resources and techniques available for the completion of these maps. The second day of the meeting was largely devoted to region or disease specific efforts. In particular, the meeting served as a platform for assessing and discussing the recent progress made into the molecular elucidation of myotonic dystrophy.

  20. Progress Towards International Repositories

    SciTech Connect

    McCombie, C.; Chapman, N.

    2002-02-27

    The nuclear fuel cycle is designed to be very international, with some specialist activities (e.g. fuel fabrication, reprocessing, etc.) being confined to a few countries. Nevertheless, political and public opposition has in the past been faced by proposals to internationalise the back-end of the cycle, in particular waste disposal. Attitudes, however, have been changing recently and there is now more acceptance of the general concept of shared repositories and of specific proposals such as that of Pangea. However, as for national facilities, progress towards implementation of shared repositories will be gradual. Moreover, the best vehicle for promoting the concept may not be a commercial type of organization. Consequently the Pangea project team are currently establishing a widely based Association for this purpose.

  1. Internal Ocean Waves

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Internal waves are waves that travel within the interior of a fluid. The waves propagate at the interface or boundary between two layers with sharp density differences, such as temperature. They occur wherever strong tides or currents and stratification occur in the neighborhood of irregular topography. They can propagate for several hundred kilometers. The ASTER false-color VNIR image off the island of Tsushima in the Korea Strait shows the signatures of several internal wave packets, indicating a northern propagation direction.

    With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.

    ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

    The broad spectral coverage and high spectral resolution of ASTER provides scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.

    The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

    Size: 60 by 120 kilometers (37.2 by 74.4 miles) Location: 34.6 degrees North latitude, 129.5 degrees East longitude Orientation: North at top Image Data: ASTER bands 3, 2, and 1

  2. Smart Image Enhancement Process

    NASA Technical Reports Server (NTRS)

    Jobson, Daniel J. (Inventor); Rahman, Zia-ur (Inventor); Woodell, Glenn A. (Inventor)

    2012-01-01

    Contrast and lightness measures are used to first classify the image as being one of non-turbid and turbid. If turbid, the original image is enhanced to generate a first enhanced image. If non-turbid, the original image is classified in terms of a merged contrast/lightness score based on the contrast and lightness measures. The non-turbid image is enhanced to generate a second enhanced image when a poor contrast/lightness score is associated therewith. When the second enhanced image has a poor contrast/lightness score associated therewith, this image is enhanced to generate a third enhanced image. A sharpness measure is computed for one image that is selected from (i) the non-turbid image, (ii) the first enhanced image, (iii) the second enhanced image when a good contrast/lightness score is associated therewith, and (iv) the third enhanced image. If the selected image is not-sharp, it is sharpened to generate a sharpened image. The final image is selected from the selected image and the sharpened image.

  3. Case study for international remote machining

    NASA Astrophysics Data System (ADS)

    Lin, Grier C. I.; Kao, Yung-Chou

    1995-08-01

    Owing to the more enhanced networking, the designed data for manufacturing can be transmitted internationally. Therefore, the production of the potential product at one side of the world according to the design requirement at the other side of the world is possible and quicker than ever before. The shipment can be eliminated by producing the product at the potential market place. This paper demonstrates the development of a machining system showing the manufacture of a product based on this idea. Unix, Microsoft Windows, and NFS under the LAN and Internet environment are adopted for data communication and message passing in the devised international remote machining system. The personal computer is the server of the machining center. A C program is developed for the direct control of the machining center through DNC2 interface. The command of machining process is issued from Sun Sparc station to the personal computer through Internet. The devised system structure can also be extended to link with an automatic workpiece loading system, e.g., robot an AGV, to form an automatic machining cell for CIM. The requirements of achieving such an international remote machining cell that links machining center and robot are also discussed.

  4. Suboptimization of developmental enhancers.

    PubMed

    Farley, Emma K; Olson, Katrina M; Zhang, Wei; Brandt, Alexander J; Rokhsar, Daniel S; Levine, Michael S

    2015-10-16

    Transcriptional enhancers direct precise on-off patterns of gene expression during development. To explore the basis for this precision, we conducted a high-throughput analysis of the Otx-a enhancer, which mediates expression in the neural plate of Ciona embryos in response to fibroblast growth factor (FGF) signaling and a localized GATA determinant. We provide evidence that enhancer specificity depends on submaximal recognition motifs having reduced binding affinities ("suboptimization"). Native GATA and ETS (FGF) binding sites contain imperfect matches to consensus motifs. Perfect matches mediate robust but ectopic patterns of gene expression. The native sites are not arranged at optimal intervals, and subtle changes in their spacing alter enhancer activity. Multiple tiers of enhancer suboptimization produce specific, but weak, patterns of expression, and we suggest that clusters of weak enhancers, including certain "superenhancers," circumvent this trade-off in specificity and activity. PMID:26472909

  5. International Spotlight: Israel

    PubMed Central

    Glicksman, Allen; Litwin, Howard

    2011-01-01

    The State of Israel provides significant opportunities to study social processes that can enhance our understanding of the aging experience. It has high life expectancy and rapid growth of its older population. With an older cohort that is composed largely of former immigrants and includes a minority Arab population, Israel provides much diversity for gerontological study. Among the unique issues facing older Israelis are the aging of Holocaust survivors, modernization in the Arab sector, and privatization in the kibbutzim. New legislation related to pensions and universal health care is expected to affect aging processes. The development of “supportive communities” offers a new service model. The article notes 2 longitudinal studies of importance—the Israeli component of the Survey of Health, Ageing, and Retirement in Europe and the Jerusalem Longitudinal Cohort Study. PMID:22038339

  6. International rotations during residency: spine deformity surgery in Ghana.

    PubMed

    Daniels, Alan H

    2013-05-01

    International elective rotations are becoming increasingly common in residency training programs. These experiences offer a tremendous opportunity to help patients in medically underserved nations, and can enhance training by exposing participants to pathology not often encountered in developed countries. Additionally, there is emerging evidence that international training exposure develops a broader appreciation of cultural diversity in patient care, offers personal and professional development, and teaches residents to use limited resources more efficiently, giving them a unique perspective on the ordering of tests and delivery of care when they return. This paper highlights the author's experience on a volunteer trip to Ghana that was focused on treating pediatric spinal deformity, and reviews notable international medical volunteers, and highlights the evidence supporting the benefits of international residency rotations.

  7. International rotations during residency: spine deformity surgery in Ghana.

    PubMed

    Daniels, Alan H

    2013-05-01

    International elective rotations are becoming increasingly common in residency training programs. These experiences offer a tremendous opportunity to help patients in medically underserved nations, and can enhance training by exposing participants to pathology not often encountered in developed countries. Additionally, there is emerging evidence that international training exposure develops a broader appreciation of cultural diversity in patient care, offers personal and professional development, and teaches residents to use limited resources more efficiently, giving them a unique perspective on the ordering of tests and delivery of care when they return. This paper highlights the author's experience on a volunteer trip to Ghana that was focused on treating pediatric spinal deformity, and reviews notable international medical volunteers, and highlights the evidence supporting the benefits of international residency rotations. PMID:23641456

  8. Internal medicine interns' and residents' pressure ulcer prevention and assessment attitudes and abilities: results of an exploratory study .

    PubMed

    Suen, Winnie; Parker, Victoria A; Harney, Lauren; Nevin, Siobhan; Jansen, Jane; Alexander, Linda; Berlowitz, Dan

    2012-04-01

    ulcers nowadays" (P = 0.0006). Both groups agreed that PU prevention is a greater priority than treatment and that using risk assessment tools is better than relying on clinical judgment. Wound assessment and PU staging results varied greatly, ranging from 100% for correct staging of a Stage I PU to 20% correct staging of an unstageable PU and 3% correct identification of a diabetic foot ulcer. Overall, internal medicine interns and residents have a favorable attitude toward PU prevention. Despite the limitations of this study, results suggest that enhanced medical school and residency wound care curricula are needed.

  9. Impacts of Culture on International Negotiations

    NASA Astrophysics Data System (ADS)

    Goodin, James Ronald

    2010-09-01

    This paper provides practical suggestions for developing a healthy and complete working relationship between the system safety practitioner and international business partners, international vendors and international customers.

  10. Enhanced lithium ion storage in nanoimprinted carbon

    SciTech Connect

    Wang, Peiqi; Chen, Qian Nataly; Li, Jiangyu; Xie, Shuhong; Liu, Xiaoyan

    2015-07-27

    Disordered carbons processed from polymers have much higher theoretical capacity as lithium ion battery anode than graphite, but they suffer from large irreversible capacity loss and have poor cyclic performance. Here, a simple process to obtain patterned carbon structure from polyvinylpyrrolidone was demonstrated, combining nanoimprint lithography for patterning and three-step heat treatment process for carbonization. The patterned carbon, without any additional binders or conductive fillers, shows remarkably improved cycling performance as Li-ion battery anode, twice as high as the theoretical value of graphite at 98 cycles. Localized electrochemical strain microscopy reveals the enhanced lithium ion activity at the nanoscale, and the control experiments suggest that the enhancement largely originates from the patterned structure, which improves surface reaction while it helps relieving the internal stress during lithium insertion and extraction. This study provides insight on fabricating patterned carbon architecture by rational design for enhanced electrochemical performance.

  11. Enhanced lithium ion storage in nanoimprinted carbon

    NASA Astrophysics Data System (ADS)

    Wang, Peiqi; Chen, Qian Nataly; Xie, Shuhong; Liu, Xiaoyan; Li, Jiangyu

    2015-07-01

    Disordered carbons processed from polymers have much higher theoretical capacity as lithium ion battery anode than graphite, but they suffer from large irreversible capacity loss and have poor cyclic performance. Here, a simple process to obtain patterned carbon structure from polyvinylpyrrolidone was demonstrated, combining nanoimprint lithography for patterning and three-step heat treatment process for carbonization. The patterned carbon, without any additional binders or conductive fillers, shows remarkably improved cycling performance as Li-ion battery anode, twice as high as the theoretical value of graphite at 98 cycles. Localized electrochemical strain microscopy reveals the enhanced lithium ion activity at the nanoscale, and the control experiments suggest that the enhancement largely originates from the patterned structure, which improves surface reaction while it helps relieving the internal stress during lithium insertion and extraction. This study provides insight on fabricating patterned carbon architecture by rational design for enhanced electrochemical performance.

  12. Credit Enhancement Overview Guide

    SciTech Connect

    Financing Solutions Working Group

    2014-01-01

    Provides considerations for state and local policymakers and energy efficiency program administrators designing and implementing successful credit enhancement strategies for residential and commercial buildings.

  13. A Preliminary Look at International Students in MSW Field Placements at Nonurban U.S. Campuses

    ERIC Educational Resources Information Center

    Zunz, Sharyn J.; Oil, Karen R.

    2009-01-01

    International students are a valuable asset to MSW programs and deserve faculty support. However, sustaining international students in their field placements can be especially challenging for programs in nonurban settings. This article begins a discussion of what might enhance such students' field internships by reporting the experiences of the…

  14. A Curriculum Framework for Faculty-Led International Programs in Geography

    ERIC Educational Resources Information Center

    Mullens, Jo Beth; Cuper, Prudence

    2015-01-01

    Faculty-led international programs are widely considered to be a highly engaging and effective means to enhance students' learning in geography. While international programs hold great opportunity for students' academic and personal growth, actualizing their potential calls for balancing the logistics with a purposefully constructed curriculum.…

  15. International Immersion in Belize: Fostering Counseling Students' Cultural Self-Awareness

    ERIC Educational Resources Information Center

    Smith-Augustine, Shirlene; Dowden, Angel; Wiggins, Angel; Hall, LaCheata

    2014-01-01

    International cultural immersion provides an in vivo, authentic, cross-cultural experience that can enhance multicultural awareness, knowledge and skills. This article examines the impact of an international immersion on graduate counseling students' cultural self-awareness using a qualitative approach. Five graduate counseling students…

  16. Influence of Multiculturalism on the Study Programs in Malaysian Public Universities: International Students' Perceptions

    ERIC Educational Resources Information Center

    Pandian, Ambigapathy; Baboo, Shanthi Balraj; Mahfoodh, Omer Hassan Ali

    2016-01-01

    In response to the emphasis on the benefits of enhanced multicultural educational experiences of international students in higher education, this study examined international students' perceptions of the influence of multiculturalism on the study programs in Malaysian public universities. Both quantitative and qualitative data were collected. The…

  17. International Graduates from Finland: Do They Satisfy the Needs of Finnish Employers Abroad?

    ERIC Educational Resources Information Center

    Cai, Yuzhuo

    2012-01-01

    It has been recognized that to increase the competitiveness of Finnish higher education institutions in the global education market international graduates' employability must be enhanced. International graduates from Finnish higher education institutions are rarely employed in Finland for a number of reasons, such as the language barrier and a…

  18. Influence of DTPA Treatment on Internal Dose Estimates.

    PubMed

    Davesne, Estelle; Blanchardon, Eric; Peleau, Bernadette; Correze, Philippe; Bohand, Sandra; Franck, Didier

    2016-06-01

    In case of internal contamination with plutonium materials, a treatment with diethylene triamine pentaacetic acid (DTPA) can be administered in order to reduce plutonium body burden and consequently avoid some radiation dose. DTPA intravenous injections or inhalation can start almost immediately after intake, in parallel with urinary and fecal bioassay sampling for dosimetric follow-up. However, urine and feces excretion will be significantly enhanced by the DTPA treatment. As internal dose is calculated from bioassay results, the DTPA effect on excretion has to be taken into account. A common method to correct bioassay data is to divide it by a factor representing the excretion enhancement under DTPA treatment by intravenous injection. Its value may be based on a nominal reference or observed after a break in the treatment. The aim of this study was to estimate the influence of this factor on internal dose by comparing the dose estimated using default or upper and lower values of the enhancement factor for 11 contamination cases. The observed upper and lower values of the enhancement factor were 18.7 and 63.0 for plutonium and 24.9 and 28.8 for americium. For americium, a default factor of 25 is proposed. This work demonstrates that the use of a default DTPA enhancement factor allows the determination of the magnitude of the contamination because dose estimated could vary by a factor of 2 depending on the value of the individual DTPA enhancement factor. In case of significant intake, an individual enhancement factor should be determined to obtain a more reliable dose assessment. PMID:27115221

  19. International red meat trade.

    PubMed

    Brester, Gary W; Marsh, John M; Plain, Ronald L

    2003-07-01

    The maturation of the US beef and pork markets and increasing consumer demands for convenience, safety, and nutrition suggests that the beef and pork industries must focus on product development and promotion. New marketing arrangements are developing that help coordinate production with consumer demands. The relative high levels of incomes in the United States are likely to increase the demands for branded products rather than increase total per capita consumption. Foreign markets represent the greatest opportunity for increased demand for commodity beef and pork products. Increasing incomes in developing countries will likely allow consumers to increase consumption of animal-source proteins. Real prices of beef and pork have declined substantially because of sagging domestic demand and increasing farm-level production technologies. Increasing US beef and pork exports have obviated some of the price declines. Pork attained a net export position from a quantity perspective in 1995. The United States continues to be a net importer of beef on a quantity basis but is close to becoming a net exporter in terms of value. By-products continue to play a critical role in determining the red meat trade balance and producer prices. The United States, however, must continue to become cost, price, and quality competitive with other suppliers and must secure additional market access if it is to sustain recent trade trends. Several trade tensions remain in the red meat industry. For example, mandated COOL will undoubtedly have domestic and international effects on the beef and pork sectors. Domestically, uncertainty regarding consumer demand responses or quality perceptions regarding product origin, as well as added processor-retailer costs will be nontrivial. How these factors balance out in terms of benefits versus costs to the industry is uncertain. From an international perspective, some beef and pork export suppliers to the United States could view required labeling as a

  20. International red meat trade.

    PubMed

    Brester, Gary W; Marsh, John M; Plain, Ronald L

    2003-07-01

    The maturation of the US beef and pork markets and increasing consumer demands for convenience, safety, and nutrition suggests that the beef and pork industries must focus on product development and promotion. New marketing arrangements are developing that help coordinate production with consumer demands. The relative high levels of incomes in the United States are likely to increase the demands for branded products rather than increase total per capita consumption. Foreign markets represent the greatest opportunity for increased demand for commodity beef and pork products. Increasing incomes in developing countries will likely allow consumers to increase consumption of animal-source proteins. Real prices of beef and pork have declined substantially because of sagging domestic demand and increasing farm-level production technologies. Increasing US beef and pork exports have obviated some of the price declines. Pork attained a net export position from a quantity perspective in 1995. The United States continues to be a net importer of beef on a quantity basis but is close to becoming a net exporter in terms of value. By-products continue to play a critical role in determining the red meat trade balance and producer prices. The United States, however, must continue to become cost, price, and quality competitive with other suppliers and must secure additional market access if it is to sustain recent trade trends. Several trade tensions remain in the red meat industry. For example, mandated COOL will undoubtedly have domestic and international effects on the beef and pork sectors. Domestically, uncertainty regarding consumer demand responses or quality perceptions regarding product origin, as well as added processor-retailer costs will be nontrivial. How these factors balance out in terms of benefits versus costs to the industry is uncertain. From an international perspective, some beef and pork export suppliers to the United States could view required labeling as a

  1. Enhanced Jumping-Droplet Departure.

    PubMed

    Kim, Moon-Kyung; Cha, Hyeongyun; Birbarah, Patrick; Chavan, Shreyas; Zhong, Chen; Xu, Yuehan; Miljkovic, Nenad

    2015-12-15

    Water vapor condensation on superhydrophobic surfaces has received much attention in recent years because of its ability to shed water droplets at length scales 3 decades smaller than the capillary length (∼1 mm) via coalescence-induced droplet jumping. Jumping-droplet condensation has been demonstrated to enhance heat transfer, anti-icing, and self-cleaning efficiency and is governed by the theoretical inertial-capillary scaled jumping speed (U). When two droplets coalesce, the experimentally measured jumping speed (Uexp) is fundamentally limited by the internal fluid dynamics during the coalescence process (Uexp < 0.23U). Here, we theoretically and experimentally demonstrate multidroplet (>2) coalescence as an avenue to break the two-droplet speed limit. Using side-view and top-view high-speed imaging to study more than 1000 jumping events on a copper oxide nanostructured superhydrophobic surface, we verify that droplet jumping occurs as a result of three fundamentally different mechanisms: (1) coalescence between two droplets, (2) coalescence among more than two droplets (multidroplet), and (3) coalescence between one or more droplets on the surface and a returning droplet that has already departed (multihop). We measured droplet-jumping speeds for a wide range of droplet radii (5-50 μm) and demonstrated that while the two-droplet capillary-to-inertial energy conversion mechanism is not identical to that of multidroplet jumping, speeds above the theoretical two-droplet limit (>0.23U) can be achieved. However, we discovered that multihop coalescence resulted in drastically reduced jumping speeds (≪0.23U) due to adverse momentum contributions from returning droplets. To quantify the impact of enhanced jumping speed on heat-transfer performance, we developed a condensation critical heat flux model to show that modest jumping speed enhancements of 50% using multidroplet jumping can enhance performance by up to 40%. Our results provide a starting point for the

  2. Differential frontal involvement in shifts of internal and perceptual attention

    PubMed Central

    Tanoue, Ryan T.; Jones, Kevin T.; Peterson, Dwight J.; Berryhill, Marian E.

    2012-01-01

    Background Perceptual attention enhances the processing of items in the environment, whereas internal attention enhances processing of items encoded in visual working memory. In perceptual and internal attention cueing paradigms, cues indicate the to-be-probed item before (pre-cueing) or after (retro-cueing) the memory display, respectively. Pre- and retro- cues confer similar behavioral accuracy benefits (pre-: 14–19%, retro-: 11–17%) and neuroimaging data show that they activate overlapping frontoparietal networks (1). Yet reports of behavioral and neuroimaging differences suggest that pre- and retro-cueing differentially recruit frontal and parietal cortices (1). Objective/Hypothesis This study examined whether perceptual and internal attention are equally disrupted by neurostimulation to frontal and parietal cortices. We hypothesized that neurostimulation applied to frontal cortex would disrupt internal attention to a greater extent than perceptual attention. Methods Cathodal transcranial direct current stimulation (tDCS) was applied to frontal or parietal cortices. After stimulation, participants completed a change detection task coupled with either pre- or retro- cues. Results Cathodal tDCS across site (frontal, parietal) hindered performance. However, frontal tDCS had a greater negative impact on the retro-cued trials demonstrating greater frontal involvement during shifts of internal attention. Conclusions These results complement the neuroimaging data and provide further evidence suggesting that perceptual and internal attention are not identical processes. We conclude that although internal and perceptual attention are mediated by similar frontoparietal networks, the weight of contribution of these structures differs, with internal attention relying more heavily on the frontal cortex. PMID:23266133

  3. International dimensions of Colombian violence.

    PubMed

    Franco, S

    2000-01-01

    Violence is the main public health problem in Colombia, as demonstrated by current homicide rates (the highest in the world), the strong effect of violence on the health care sector, and the forceful displacement of citizens, among other factors. This violence has international dimensions and consequences: inequity resulting from the political-economic system and increased by the neoliberal adjustments; the international traffic of drugs and weapons; exile and forceful displacement of persons into bordering countries; and frequent violations of human rights and humanitarian international rights. The international community can play a role in the search for a solution to this problem, as the author discusses in terms of contributions made in the past and those that could be made in the near future. Colombian violence can be viewed as a problem, a message, and a challenge for international public health, and the author suggests specific areas in which international public health could contribute to the study and solution of this complex situation.

  4. Update in Internal Medicine

    PubMed Central

    López-Jiménez, Francisco; Brito, Máximo; Aude, Y. Wady; Scheinberg, Phillip; Kaplan, Mariana; Dixon, Denise A.; Schneiderman, Neil; Trejo, Jorge F.; López-Salazar, Luis Humberto; Ramírez-Barba, Ector Jaime; Kalil, Roberto; Ortiz, Carmen; Goyos, José; Buenaño, Alvaro; Kottiech, Samer; Lamas, Gervasio A.

    2009-01-01

    More than 500,000 new medical articles are published every year and available time to keep updated is scarcer every day. Nowadays, the task of selecting useful, consistent, and relevant information for clinicians is a priority in many major medical journals. This review has the aim of gathering the results of the most important findings in clinical medicine in the last few years. It is focused on results from randomized clinical trials and well-designed observational research. Findings were included preferentially if they showed solid results, and we avoided as much as possible including only preliminary data, or results that included only non-clinical outcomes. Some of the most relevant findings reported here include the significant benefit of statins in patients with coronary artery disease even with mean cholesterol level. It also provides a substantial review of the most significant trials assessing the effectiveness of IIb/IIIa receptor blockers. In gastroenterology many advances have been made in the H. pylori eradication, and the finding that the cure of H. pylori infection may be followed by gastroesophageal reflux disease. Some new antivirals have shown encouraging results in patients with chronic hepatitis. In the infectious disease arena, the late breaking trials in anti-retroviral disease are discussed, as well as the new trends regarding antibiotic resistance. This review approaches also the role of leukotriene modifiers in the treatment of asthma and discusses the benefit of using methylprednisolone in patients with adult respiratory distress syndrome, among many other advances in internal medicine. PMID:11068074

  5. Biometrics and international migration.

    PubMed

    Redpath, Jillyanne

    2007-01-01

    This paper will focus on the impact of the rapid expansion in the use of biometric systems in migration management on the rights of individuals; it seeks to highlight legal issues for consideration in implementing such systems, taking as the starting point that the security interests of the state and the rights of the individual are not, and should not be, mutually exclusive. The first part of this paper briefly describes the type of biometric applications available, how biometric systems function, and those used in migration management. The second part examines the potential offered by biometrics for greater security in migration management, and focuses on developments in the use of biometrics as a result of September 11. The third part discusses the impact of the use of biometrics in the management of migration on the individual's right to privacy and ability to move freely and lawfully. The paper highlights the increasing need for domestic and international frameworks to govern the use of biometric applications in the migration/security context, and proposes a number of issues that such frameworks could address. PMID:17536151

  6. International Ultraviolet Explorer (IUE)

    NASA Technical Reports Server (NTRS)

    Boehm, Karl-Heinz

    1992-01-01

    The observation, data reduction, and interpretation of ultraviolet spectra (obtained with the International Ultraviolet Explorer) of Herbig-Haro objects, stellar jets, and (in a few cases) reflection nebulae in star-forming regions is discussed. Intermediate results have been reported in the required semi-annual reports. The observations for this research were obtained in 23 (US1) IUE shifts. The spectra were taken in the low resolution mode with the large aperture. The following topics were investigated: (1) detection of UV spectra of high excitation Herbig-Haro (HH) objects, identification of emission lines, and a preliminary study of the energy distribution of the ultraviolet continuum; (2) details of the continuum energy distribution of these spectra and their possible interpretation; (3) the properties of the reddening (extinction) of HH objects; (4) the possible time variation of strong emission lines in high excitation HH objects; (5) the ultraviolet emission of low excitation HH objects, especially in the fluorescent lines of the H2 molecule; (6) the ultraviolet emission in the peculiar object HH24; (7) the spatial emission distribution of different lines and different parts of the continuum in different HH objects; and (8) some properties of reflection nebula, in the environment of Herbig-Haro objects. Each topic is discussed.

  7. The International Heliophysical Year

    NASA Technical Reports Server (NTRS)

    Davila, Joseph M.; Gopalswamy, Nat; Thompson, Barbara

    2008-01-01

    It is now widely recognized that evolution in the solar system proceeds through a set of Universal Processes, i.e. reconnection, particle acceleration, plasma wave generation and propagation, etc. By studying these Universal Processes together, in diverse environments, and in a comparative way, new scientific insights will be gained. This is perhaps best understood by citing a few examples: (I) Shocks are observed in situ in the interplanetary medium, shocks are believed to play a role in the acceleration of particles in the solar corona, and standing bow shocks and termination shocks separate the major regions in the heliosphere. Shock formation, and particle acceleration are universal processes. (2) Aurorae are observed on Earth, Saturn, and Jupiter, and Jovian auroral "footprints" have been observed on 10, Ganymede and Europa. The formation of aurorae is observed to be the universal response of a magnetized body in the solar wind. The International Heliophysical Year (IHY) specifically highlights the cross-disciplinary study of universal physical processes in the solar system, observed in a variety of settings. The study of these processes will provide new insights that will lead to a better understanding of the universal processes in the solar system that affect the interplanetary and planetary environments, and pave the way for safe human space travel to the Moon and planets in the future, and it will serve to inspire the next generation of space physicists.

  8. International energy outlook 1999

    SciTech Connect

    1999-03-01

    This report presents international energy projections through 2020, prepared by the Energy Information Administration. The outlooks for major energy fuels are discussed, along with electricity, transportation, and environmental issues. The report begins with a review of world trends in energy demand. The historical time frame begins with data from 1970 and extends to 1996, providing readers with a 26-year historical view of energy demand. The IEO99 projections covers a 24-year period. The next part of the report is organized by energy source. Regional consumption projections for oil, natural gas, coal, nuclear power, and renewable energy (hydroelectricity, geothermal, wind, solar, and other renewables) are presented in the five fuel chapters, along with a review of the current status of each fuel on a worldwide basis. The third part of the report looks at energy consumption in the end-use sectors, beginning with a chapter on energy use for electricity generation. New to this year`s outlook are chapters on energy use in the transportation sector and on environmental issues related to energy consumption. 104 figs., 87 tabs.

  9. International energy indicators

    NASA Astrophysics Data System (ADS)

    Bauer, E. K.

    1980-03-01

    For the international sector, a table of data is first presented followed by corresponding graphs of the data for the following: (1) Iran: crude oil capacity, production, and shut in, 1974 to February 1980; (2) Saudi Arabia (same as Iran); (3) OPEC (ex-Iran and Saudi Arabia); capacity, production, and shutin, 1974 to January 1980; (4) non-OPEC Free World and US production of crude oil, 1973 to January 1980; (5) oil stocks: Free World, US, Japan, and Europe (landed), 1973 to 1979; (6) petroleum consumption by industrial countries, 1973 to October 1979; (7) USSR crude oil production, 1974 to February 1980; (8) Free World and US nuclear generation capacity, 1973 to January 1980. For the United States, the same data format is used for the following: US imports of crude oil and products 1973 to January 1980; landed cost of Saudi Arabia crude oil in current and 1974 dollars, 1974 to October 1979; US trade in coal, 1973 to 1979; summary of US merchandise trade, 1976 to January 1980; and US energy/GNP ratio (in 1972 dollars), 1947 to 1979.

  10. Internal combustion engine

    SciTech Connect

    Breckenfeld, P.W.; Broughton, G.L.; Forquer, D.W.

    1990-02-19

    This patent describes a two-stroke internal combustion engine. It comprises: an engine block including an exterior planar surface portion having therein a pair of spaced bearing surfaces and a crankcase-defining cavity which includes a pair of spaced semi-cylindrical surfaces, a crankshaft including a pair of spaced bearing portions and a central part which is located between the bearing portions and which includes a pair of spaced and enlarged cylindrical surfaces, a pair of bearing blocks respectively including bearing surfaces, means fixing the bearing blocks to the exterior planar surface portion with each of the crankshaft bearing portions retained between a respective one of the bearing surfaces of the engine block and a respective one of the bearing surfaces of the bearing blocks and with each of the crankshaft cylindrical surfaces in coplanar relation to a respective one of the semi-cylindrical surfaces of the engine block, a crankcase cover including a mounting surface having therein a crankcase-defining cavity including a pair of spaced semi-cylindrical surfaces, and means fixedly connecting the mounting surface of the crankcase cover to the exterior planar surface portion of block with each of the semi-cylindrical surfaces of the crankcase cover in generally coplanar relation to a respective one of the semi-cylindrical surfaces of the engine block.

  11. International exploration by independents

    SciTech Connect

    Bertagne, R.G. )

    1991-03-01

    Recent industry trends indicate that the smaller US independents are looking at foreign exploration opportunities as one of the alternatives for growth in the new age of exploration. It is usually accepted that foreign finding costs per barrel are substantially lower than domestic because of the large reserve potential of international plays. To get involved overseas requires, however, an adaptation to different cultural, financial, legal, operational, and political conditions. Generally foreign exploration proceeds at a slower pace than domestic because concessions are granted by the government, or are explored in partnership with the national oil company. First, a mid- to long-term strategy, tailored to the goals and the financial capabilities of the company, must be prepared; it must be followed by an ongoing evaluation of quality prospects in various sedimentary basins, and a careful planning and conduct of the operations. To successfully explore overseas also requires the presence on the team of a minimum number of explorationists and engineers thoroughly familiar with the various exploratory and operational aspects of foreign work, having had a considerable amount of onsite experience in various geographical and climatic environments. Independents that are best suited for foreign expansion are those that have been financially successful domestically, and have a good discovery track record. When properly approached foreign exploration is well within the reach of smaller US independents and presents essentially no greater risk than domestic exploration; the reward, however, can be much larger and can catapult the company into the big leagues.

  12. International exploration by independent

    SciTech Connect

    Bertragne, R.G.

    1992-04-01

    Recent industry trends indicate that the smaller U.S. independents are looking at foreign exploration opportunities as one of the alternatives for growth in the new age of exploration. Foreign finding costs per barrel usually are accepted to be substantially lower than domestic costs because of the large reserve potential of international plays. To get involved in overseas exploration, however, requires the explorationist to adapt to different cultural, financial, legal, operational, and political conditions. Generally, foreign exploration proceeds at a slower pace than domestic exploration because concessions are granted by a country's government, or are explored in partnership with a national oil company. First, the explorationist must prepare a mid- to long-term strategy, tailored to the goals and the financial capabilities of the company; next, is an ongoing evaluation of quality prospects in various sedimentary basins, and careful planning and conduct of the operations. To successfully explore overseas also requires the presence of a minimum number of explorationists and engineers thoroughly familiar with the various exploratory and operational aspects of foreign work. Ideally, these team members will have had a considerable amount of on-site experience in various countries and climates. Independents best suited for foreign expansion are those who have been financially successful in domestic exploration. When properly approached, foreign exploration is well within the reach of smaller U.S. independents, and presents essentially no greater risk than domestic exploration; however, the reward can be much larger and can catapult the company into the 'big leagues.'

  13. Internal Surface Water Flows

    USGS Publications Warehouse

    Murray, Mitchell H.

    1999-01-01

    Introduction The South Florida Ecosystem Restoration Program is an intergovernmental effort to reestablish and maintain the ecosystem of south Florida. One element of the restoration effort is the development of a firm scientific basis for resource decision making.The U.S. Geological Survey (USGS) provides scientitic information as part of the South Florida Ecosystem Restoration Program. The USGS began its own project, called the South Florida Ecosystem Project in fiscal year 1995 for the purpose of gathering hydrologic, cartographic, and geologic data that relate to the mainland of south Florida, Florida Bay, and the Florida Keys and Reef ecosystems. Historical changes in water-management practices to accommodate a large and rapidly growing urban population along the Atlantic coast, as well as intensive agricultural activities, have resulted in a highly managed hydrologic system with canals, levees, and pumping stations. These structures have altered the hydology of the Everglades ecosystem on both coastal and interior lands. Surface-water flows in a direction south of Lake Okeechobee have been regulated by an extensive canal network, begun in the 1940's, to provide for drainage, flood control, saltwater intrusion control, agricultural requirements, and various environmental needs. Much of the development and subsequent monitoring of canal and river discharge south of Lake Okeechobee has traditionally emphasized the eastern coastal areas of Florida. Recently, more emphasis has been placed on providing a more accurate water budget for internal canal flows.

  14. Solid rocket motor internal insulation

    NASA Technical Reports Server (NTRS)

    Twichell, S. E. (Editor); Keller, R. B., Jr.

    1976-01-01

    Internal insulation in a solid rocket motor is defined as a layer of heat barrier material placed between the internal surface of the case propellant. The primary purpose is to prevent the case from reaching temperatures that endanger its structural integrity. Secondary functions of the insulation are listed and guidelines for avoiding critical problems in the development of internal insulation for rocket motors are presented.

  15. International Energy Module - NEMS Documentation

    EIA Publications

    2014-01-01

    Summarizes the overall structure of the International Energy Model and its interface with other NEMS modules, mathematical specifications of behavioral relationships, and data sources and estimation methods.

  16. International Space Station Research Racks

    NASA Video Gallery

    The International Space Station has a variety of multidisciplinary laboratory facilities and equipment available for scientists to use. This video highlights the capabilities of select facilities. ...

  17. The neurophysiological validation of the hyperpolarization theory of internal inhibition.

    PubMed

    Shulgina, Galina I

    2005-05-01

    The experiments in conscious non-immobilized rabbits showed that cessation of the reactions without reinforcement (elaboration of the internal inhibition) is accompanied by an enhanced phasic state, by alternation of activation and inhibition of neuron firing, and by the corresponding slow potential oscillation (SPO). These changes can be either localized, predominantly in the structures of conditioned stimulus, or, under enhancement of the inhibitory state, generalized in the brain structures. On the basis of our experience and published data, it is concluded that the above event results from relative enhancement of the inhibitory hyperpolarizing processes due to increase in reactivity of the inhibitory systems to stimulus, which acquires inhibitory properties during learning. Changes in the excitability and reactivity of neuron populations appearing during enhancement of the hyperpolarizing inhibition, and differing in the various brain structures, play an active role in the execution of the main function of the internal inhibition: limitation of excitation transmission to the effectors. An inhibitory mediator gamma aminobutyric acid (GABA) is of great importance in inhibiting the excitation in response to the stimulus which lost its biological significance. These experimental data and their interpretation in the light of published data give the basis for the development of the hyperpolarization theory of internal inhibition.

  18. Comparing International Curriculum Systems: The International Instructional Systems Study

    ERIC Educational Resources Information Center

    Creese, Brian; Gonzalez, Alvaro; Isaacs, Tina

    2016-01-01

    This paper sets out the main findings of the International Instructional Systems Study (IISS), conducted by the UCL Institute of Education and funded by the Center on International Education Benchmarking (CIEB). The study examined the instructional systems and intended curricula of six "high performing" countries and two US states. The…

  19. Teaching International Economics and Trade--Concepts in International Relations

    ERIC Educational Resources Information Center

    Starbird, Caroline; DeBoer, Dale; Pettit, Jenny

    2004-01-01

    The purpose of this book is to introduce students to real-life issues in international economics. The sections of the book are: (1) The Advantages of Trade; (2) Judging NAFTA; (3) Does Globalization Benefit Poor Countries?; (4) Pocket Guide to International Financial Institutions; (5) What Do You Know about the WTO?; (6) Free Trade and Shifting…

  20. International Relations. International Perspectives on Higher Education Research. Volume 3

    ERIC Educational Resources Information Center

    Tight, Malcolm, Ed.

    2005-01-01

    This is the third volume of International Perspectives on Higher Education Research, a series which aims to feature something of the variety of research being undertaken into higher education systems and issues outside of North America. The theme of this volume is International Relations, or how students, academics, universities and higher…