Phasing operator for two oscillators in classical field

NASA Technical Reports Server (NTRS)

Kim, Jong-Jean; Koo, Je-Hwan; Bae, Dong-Jae

1993-01-01

The origin of Dicke cooperative states was studied by considering two harmonic oscillators driven by a common field of radiation. The origin is assumed for superradiance in a system of molecules where no mutual interactions exist, but all of the molecules encounter the same field of radiation. A phasing operator as Phi(sub Nu) equals D(alpha) + P(sub Nu)D(alpha), where D(alpha) is the displacing operator and P(sub Nu) the projection operator for constant energy Nu for two oscillators, was derived. The eigenstates of the phasing operator Phi are found to show a finite correlation as in the Dicke cooperative states.

Parlaying the Prison Experience

ERIC Educational Resources Information Center

Gray, Katti

2010-01-01

At the close of almost 25 years of winding through New York state's prisons, former Black Panther Eddie Ellis walked away in 1994 with four college degrees he earned while incarcerated and kept treading his singular path as an activist on the issues of police, courts, crime and punishment. He then established the Center for NuLeadership on Urban…

Anomalous diffusion associated with nonlinear fractional derivative fokker-planck-like equation: exact time-dependent solutions

PubMed

Bologna; Tsallis; Grigolini

2000-08-01

We consider the d=1 nonlinear Fokker-Planck-like equation with fractional derivatives ( partial differential/ partial differentialt)P(x,t)=D( partial differential(gamma)/ partial differentialx(gamma))[P(x,t)](nu). Exact time-dependent solutions are found for nu=(2-gamma)/(1+gamma)(-infinity

Even with nonnative interactions, the updated folding transition states of the homologs Proteins G & L are extensive and similar

PubMed Central

Baxa, Michael C.; Yu, Wookyung; Adhikari, Aashish N.; Ge, Liang; Xia, Zhen; Zhou, Ruhong; Freed, Karl F.; Sosnick, Tobin R.

2015-01-01

Experimental and computational folding studies of Proteins L & G and NuG2 typically find that sequence differences determine which of the two hairpins is formed in the transition state ensemble (TSE). However, our recent work on Protein L finds that its TSE contains both hairpins, compelling a reassessment of the influence of sequence on the folding behavior of the other two homologs. We characterize the TSEs for Protein G and NuG2b, a triple mutant of NuG2, using ψ analysis, a method for identifying contacts in the TSE. All three homologs are found to share a common and near-native TSE topology with interactions between all four strands. However, the helical content varies in the TSE, being largely absent in Proteins G & L but partially present in NuG2b. The variability likely arises from competing propensities for the formation of nonnative β turns in the naturally occurring proteins, as observed in our TerItFix folding algorithm. All-atom folding simulations of NuG2b recapitulate the observed TSEs with four strands for 5 of 27 transition paths [Lindorff-Larsen K, Piana S, Dror RO, Shaw DE (2011) Science 334(6055):517–520]. Our data support the view that homologous proteins have similar folding mechanisms, even when nonnative interactions are present in the transition state. These findings emphasize the ongoing challenge of accurately characterizing and predicting TSEs, even for relatively simple proteins. PMID:26100906

The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.

PubMed

Choi, Won-Il; Jeon, Bu-Nam; Yoon, Jae-Hyeon; Koh, Dong-In; Kim, Myung-Hwa; Yu, Mi-Young; Lee, Kyung-Mi; Kim, Youngsoo; Kim, Kyunggon; Hur, Sujin Susanne; Lee, Choong-Eun; Kim, Kyung-Sup; Hur, Man-Wook

2013-07-01

The tumour-suppressor gene CDKN1A (encoding p21Waf/Cip1) is thought to be epigenetically repressed in cancer cells. FBI-1 (ZBTB7A) is a proto-oncogenic transcription factor repressing the alternative reading frame and p21WAF/CDKN1A genes of the p53 pathway. FBI-1 interacts directly with MBD3 (methyl-CpG-binding domain protein 3) in the nucleus. We demonstrated that FBI-1 binds both non-methylated and methylated DNA and that MBD3 is recruited to the CDKN1A promoter through its interaction with FBI-1, where it enhances transcriptional repression by FBI-1. FBI-1 also interacts with the co-repressors nuclear receptor corepressor (NCoR), silencing mediator for retinoid and thyroid receptors (SMRT) and BCL-6 corepressor (BCoR) to repress transcription. MBD3 regulates a molecular interaction between the co-repressor and FBI-1. MBD3 decreases the interaction between FBI-1 and NCoR/SMRT but increases the interaction between FBI-1 and BCoR. Because MBD3 is a subunit of the Mi-2 autoantigen (Mi-2)/nucleosome remodelling and histone deacetylase (NuRD)-HDAC complex, FBI-1 recruits the Mi-2/NuRD-HDAC complex via MBD3. BCoR interacts with the Mi-2/NuRD-HDAC complex, DNMTs and HP1. MBD3 and BCoR play a significant role in the recruitment of the Mi-2/NuRD-HDAC complex- and the NuRD complex-associated proteins, DNMTs and HP. By recruiting DNMTs and HP1, Mi-2/NuRD-HDAC complex appears to play key roles in epigenetic repression of CDKN1A by DNA methylation.

Plasma and Salivary Non-Urate Total Antioxidant Capacity Does Not Depend on Dietary Vitamin C, E, or β-Carotene Intake in Older Subjects.

PubMed

Gawron-Skarbek, Anna; Guligowska, Agnieszka; Prymont-Przymińska, Anna; Nowak, Dariusz; Kostka, Tomasz

2018-04-23

The native Total Antioxidant Capacity (TAC) of plasma and saliva is generally determined by uric acid (UA). Several studies have assessed the impact of habitual dietary antioxidative vitamin intake on TAC, but it remains unknown whether it influences Non-Urate Total Antioxidant Capacity (Nu-TAC), i.e., TAC after enzymatic UA elimination. The purpose of this study was to assess whether the intake of antioxidative vitamins C, E, and β-carotene, provided with usual daily food rations, affects plasma and salivary Nu-TAC. The study involved 56 older subjects (aged 66.9 ± 4.3 years), divided into two age- and sex-matched groups: group 1 ( n = 28), with lower combined vitamin C, E, and β-carotene intake, and group 2 ( n = 28), with higher intake. A 24 h dietary recall was obtained from each individual. Nu-TAC was assessed simultaneously with two methods in plasma (Ferric Reducing Ability of Plasma—Nu-FRAP, 2.2-diphenyl-1-picryl-hydrazyl—Nu-DPPH) and in saliva (Nu-FRAS and Nu-DPPHS test). No differences were found in the Nu-TAC parameters between the groups, either in plasma (Nu-FRAP, Nu-DPPH) or in saliva (Nu-FRAS, Nu-DPPHS) ( p > 0.05). No plasma or salivary Nu-TAC indices correlated with dietary vitamin C, E, or β-carotene intake or with other nutrients. Habitual, not extra-supplemented dietary intake does not significantly affect plasma or salivary Nu-TAC.

Eaf1p Is Required for Recruitment of NuA4 in Targeting TFIID to the Promoters of the Ribosomal Protein Genes for Transcriptional Initiation In Vivo

PubMed Central

Uprety, Bhawana; Sen, Rwik

2015-01-01

NuA4 (nucleosome acetyltransferase of H4) promotes transcriptional initiation of TFIID (a complex of TBP and TBP-associated factors [TAFs])-dependent ribosomal protein genes involved in ribosome biogenesis. However, it is not clearly understood how NuA4 regulates the transcription of ribosomal protein genes. Here, we show that NuA4 is recruited to the promoters of ribosomal protein genes, such as RPS5, RPL2B, and RPS11B, for TFIID recruitment to initiate transcription, and the recruitment of NuA4 to these promoters is impaired in the absence of its Eaf1p component. Intriguingly, impaired NuA4 recruitment in a Δeaf1 strain depletes recruitment of TFIID (a TAF-dependent form of TBP) but not the TAF-independent form of TBP to the promoters of ribosomal protein genes. However, in the absence of NuA4, SAGA (Spt-Ada-Gcn5-acetyltransferase) is involved in targeting the TAF-independent form of TBP to the promoters of ribosomal protein genes for transcriptional initiation. Thus, NuA4 plays an important role in targeting TFIID to the promoters of ribosomal protein genes for transcriptional initiation in vivo. Such a function is mediated via its targeted histone acetyltransferase activity. In the absence of NuA4, ribosomal protein genes lose TFIID dependency and become SAGA dependent for transcriptional initiation. Collectively, these results provide significant insights into the regulation of ribosomal protein gene expression and, hence, ribosome biogenesis and functions. PMID:26100014

nu/TPU -- A DEC TPU compatible editor for UNIX

NASA Astrophysics Data System (ADS)

Rehan, S. C.

nu/TPU is a fully programmable text processing utility compatible with the TPU system found on VMS systems. People used to using TPU or EDT on the former Starlink VAX/VMS service will find that nu/TPU is very similar to these editors.

Transportable telemetry workstation

NASA Technical Reports Server (NTRS)

Collins, Aaron S.

1989-01-01

The goal was to complete the design of a prototype for a Transportable Telemetry Workstation (TTW). The Macintosh 2 is used to provide a low-cost system which can house real-time cards mounted on the NuBus inside the Macintosh 2 plus provide a standardized user interface on the Macintosh 2 console. Prior to a telemetry run, the user will be able to configure his real-time telemetry processing functions from the Macintosh 2 console. During a telemetry run, the real-time cards will store the telemetry data directly on a hard disk while permitting viewing of the data cards on the Macintosh 2 console on various selectable formats. The user will view the cards in terms of the functions they perform and the selectable paths through the cards, it is not required to become involved directly in hardware issue except in terms of the functional configuration of the system components. The TTW will accept telemetry data from an RS422 serial input data bus, pass it through a frame synchronizer card and on to a real time controller card via a telemetry backplane bus. The controller card will then route the data to a hard disk through a SCSI interface, and/or to a user interface on the Macintosh 2 console by way of the Macintosh 2 NuBus. The three major components to be designed, therefore, are the TTW Controller Card, the TTW Synchronizer Card, and the NuBus/Macintosh 2 User Interface. Design and prototyping of this state-of-the-art, transportable, low-cost, easy-to-use multiprocessor telemetry system is continuing. Other functions are planned for the future.

Transportable telemetry workstation

NASA Astrophysics Data System (ADS)

Collins, Aaron S.

1989-09-01

The goal was to complete the design of a prototype for a Transportable Telemetry Workstation (TTW). The Macintosh 2 is used to provide a low-cost system which can house real-time cards mounted on the NuBus inside the Macintosh 2 plus provide a standardized user interface on the Macintosh 2 console. Prior to a telemetry run, the user will be able to configure his real-time telemetry processing functions from the Macintosh 2 console. During a telemetry run, the real-time cards will store the telemetry data directly on a hard disk while permitting viewing of the data cards on the Macintosh 2 console on various selectable formats. The user will view the cards in terms of the functions they perform and the selectable paths through the cards, it is not required to become involved directly in hardware issue except in terms of the functional configuration of the system components. The TTW will accept telemetry data from an RS422 serial input data bus, pass it through a frame synchronizer card and on to a real time controller card via a telemetry backplane bus. The controller card will then route the data to a hard disk through a SCSI interface, and/or to a user interface on the Macintosh 2 console by way of the Macintosh 2 NuBus. The three major components to be designed, therefore, are the TTW Controller Card, the TTW Synchronizer Card, and the NuBus/Macintosh 2 User Interface. Design and prototyping of this state-of-the-art, transportable, low-cost, easy-to-use multiprocessor telemetry system is continuing. Other functions are planned for the future.

Limited proteolysis of rat liver nucleolin by endogenous proteases: effects of polyamines and histones.

PubMed Central

Suzuki, T; Suzuki, N; Hosoya, T

1993-01-01

Nucleolin is a major nucleolar phosphoprotein and is presumably involved in rDNA transcription and ribosome biosynthesis. This protein is known to be very labile and to be cleaved by endogenous proteases into many small peptides. We found that, when rat liver nucleolar suspension (Nu-1) or nucleolin-rich extract (Nu-2) was incubated under conventional conditions, polyamines and histones interacted with the nucleolin to lead to its preferential degradation to 60 kDa phosphopeptide (p60). The peptide p60 was identified as a peptide containing the N-terminal half of the nucleolin molecule, as judged from peptide-map analysis. Whereas spermine binding to the purified nucleolin was decreased by KCl concentrations above 50 mM, histones (H1, H2B and H3) were able to bind to the nucleolin in the presence of up to 300 mM KCl. A distinct difference between H1 and other histones was found in that H1 could produce p60 from nucleolin in both Nu-1 and Nu-2, whereas H2B and H3 stimulated the degradation of nucleolin to p60 only when Nu-2 was used for the source of nucleolin. A possible relationship between p60 formation and rRNA synthesis is discussed, but its exact role remains to be studied. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 PMID:8424749

The NH3 spectrum in Saturn's 5 micron window

NASA Technical Reports Server (NTRS)

Bjoraker, G. L.; Fink, U.; Larson, H. P.; Johnson, J. R.

1983-01-01

Spectra of Saturn's 5-micron window were obtained at the Infrared Telescope Facility on Mauna Kea, Hawaii. The spectra have a resolution of 1.2/cm, and some exhibit extremely low amounts of approximately 300-micron ppt telluric H2O. The Saturn spectra show absorptions by the 2nu2 band of NH3. Long-path laboratory comparison spectra of NH3 were acquired and show considerable deviations in intensity from theoretical predictions. The calibration of Saturn's observed NH3 features with the laboratory data gives 2.0 + or - 0.5 m-amagat of NH3 using the 2nu2 Q-branch at 5.32 microns. The R(1) and R(2) lines yield an abundance about 3 times greater. Absorptions outside the range of the Q-branch can be accounted for by solid NH3 of 10-20 microns equivalent path length. The origin of Saturn's 5-micron flux is mostly thermal with some admixture of solar reflected radiation. A depletion of Saturn's NH3 abundance below the solar value is indicated, but confirmation of this conclusion will require a better understanding of the atmospheric penetration depth at 5 microns and more rigorous modeling of the spectral line formation.

On p-mode oscillations in stars from 1 solar mass to 2 solar masses

NASA Astrophysics Data System (ADS)

Audard, N.; Provost, J.

1994-06-01

The structure of stars more massive than about 1.2 solar masses is characterized by a convective core. We have studied the evolution with age and mass of acoustic frequencies of high radical order n and low degree l for models of stars of 1, 1.5 and 2 solar masses. Using a polynomial approximation for the frequency, the p-mode spectrum can be characterized by derived global asteroseismic coefficients, i.e. the mean separation nu0 is approximately equal to nun, l - nun - 1, l and the small frequency separation Delta nu0, 2 is approximately equal to nun, l = 0 - nun - 1, l = 2. The diagram (nu0, delta nu0, 2/nu0) plotted along the evolutionary tracks would help to separate the effects of age and mass. We study the sensitivity of these coefficients and other observable quantities, like the radius and luminosity, to stellar parameters in the vicinity of 1 solar mass and 2 solar masses; this sensitivity substantially depends on the stellar mass and must be taken into account for asteroseismic calibration of stellar clusters. Considering finally some rapid variations of the internal structure, we show that the second frequency difference delta2 nu = nu(subn, l) - 2 nun - 1, l + nun - 2, l exponent gamma in the He II ionization zone.

The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation

PubMed Central

Choi, Won-Il; Jeon, Bu-Nam; Yoon, Jae-Hyeon; Koh, Dong-In; Kim, Myung-Hwa; Yu, Mi-Young; Lee, Kyung-Mi; Kim, Youngsoo; Kim, Kyunggon; Hur, Sujin Susanne; Lee, Choong-Eun; Kim, Kyung-Sup; Hur, Man-Wook

2013-01-01

The tumour-suppressor gene CDKN1A (encoding p21Waf/Cip1) is thought to be epigenetically repressed in cancer cells. FBI-1 (ZBTB7A) is a proto-oncogenic transcription factor repressing the alternative reading frame and p21WAF/CDKN1A genes of the p53 pathway. FBI-1 interacts directly with MBD3 (methyl-CpG–binding domain protein 3) in the nucleus. We demonstrated that FBI-1 binds both non-methylated and methylated DNA and that MBD3 is recruited to the CDKN1A promoter through its interaction with FBI-1, where it enhances transcriptional repression by FBI-1. FBI-1 also interacts with the co-repressors nuclear receptor corepressor (NCoR), silencing mediator for retinoid and thyroid receptors (SMRT) and BCL-6 corepressor (BCoR) to repress transcription. MBD3 regulates a molecular interaction between the co-repressor and FBI-1. MBD3 decreases the interaction between FBI-1 and NCoR/SMRT but increases the interaction between FBI-1 and BCoR. Because MBD3 is a subunit of the Mi-2 autoantigen (Mi-2)/nucleosome remodelling and histone deacetylase (NuRD)-HDAC complex, FBI-1 recruits the Mi-2/NuRD-HDAC complex via MBD3. BCoR interacts with the Mi-2/NuRD-HDAC complex, DNMTs and HP1. MBD3 and BCoR play a significant role in the recruitment of the Mi-2/NuRD-HDAC complex– and the NuRD complex–associated proteins, DNMTs and HP. By recruiting DNMTs and HP1, Mi-2/NuRD-HDAC complex appears to play key roles in epigenetic repression of CDKN1A by DNA methylation. PMID:23658227

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abazov, V.M.; /Dubna, JINR; Abbott, B.

A search is performed for the standard model Higgs boson in 5.2 fb{sup -1} of p{bar p} collisions at {radical}s = 1.96 TeV, collected with the D0 detector at the Fermilab Tevatron Collider. The final state considered is a pair of b jets and large missing transverse energy, as expected from p{bar p} {yields} ZH {yields} {nu}{bar {nu}}b{bar b} production. The search is also sensitive to the WH {yields} {ell}{nu}b{bar b} channel when the charged lepton is not identified. For a Higgs boson mass of 115 GeV, a limit is set at the 95% C.L. on the cross section multipliedmore » by branching fraction for (p{bar p} {yields} (Z/W)H) x (H {yields} b{bar b}) that is a factor of 3.7 larger than the standard model value, consistent with the factor of 4.6 expected.« less

The role of proton shuttling mechanisms in solvent-free and catalyst-free acetalization reactions of imines.

PubMed

Lillo, Victor J; Mansilla, Javier; Saá, José M

2018-06-06

Proton transfer is central to the understanding of chemical processes. More so in addition reactions of the type NuH + E → Nu-EH taking place under solvent-free and catalyst-free conditions. Herein we show that the addition of alcohols or amines (the NuH component) to imine derivatives (the E component), in 1 : 1 ratio, under solvent-free and catalyst-free conditions, are efficient methods to access N,O and N,N-acetal derivatives. In addition, computational studies reveal that they are catalyzed reactions involving two or even three NuH molecules operating in a cooperative manner as H-bonded NuH(NuH)nNuH associates (many body effects) in the transition state through a concerted proton shuttling mechanism (addition of alcohols) or stepwise proton shuttling mechanism (addition of amines), thereby facilitating the key proton transfer step.

Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders

DOEpatents

Lelievre, Sophie; Bissell, Mina

2001-01-01

The localization of nuclear apparatus proteins (NUMA) is used to identify tumor cells and different stages in the tumor progression and differentiation processes. There is a characteristic organization of NuMA in tumor cells and in phenotypically normal cells. NuMA distribution patterns are significantly less diffuse in proliferating non-malignant cells compared to malignant cells. The technique encompasses cell immunostaining using a NuMA specific antibody, and microscopic analysis of NuMA distribution within each nucleus.

Noninvasive determination of cell nucleoplasmic viscosity by fluorescence correlation spectroscopy

NASA Astrophysics Data System (ADS)

Liang, Lifang; Wang, Xichao; Xing, Da; Chen, Tongsheng; Chen, Wei R.

2009-03-01

Noninvasive and reliable quantification of rheological characteristics in the nucleus is extremely useful for fundamental research and practical applications in medicine and biology. This study examines the use of fluorescence correlation spectroscopy (FCS) to noninvasively determine nucleoplasmic viscosity (ɛnu), an important parameter of nucleoplasmic rheology. Our FCS analyses show that ɛnu of lung adenocarcinoma (ASTC-a-1) and HeLa cells are 1.77+/-0.42 cP and 1.40+/-0.27 cP, respectively, about three to four times larger than the water viscosity at 37 °C. ɛnu was reduced by 31 to 36% upon hypotonic exposure and increased by 28 to 52% from 37 to 24 °C. In addition, we found that ɛnu of HeLa cells reached the lowest value in the S phase and that there was no significant difference of ɛnu between in the G1 and G2 phases. Last, nucleoplasmic viscosity was found to be larger than cytoplasmic viscosity in both HeLa and ASTC-a-1 cells. These results indicate that FCS can be used as a noninvasive tool to investigate the microenvironment of living cells. This is the first report on the measurement of ɛnu in living cells synchronized in the G1, S, and G2 phases.

Stimulated emission pumping spectroscopy of the [X](1)A' state of CHF.

PubMed

Mukarakate, Calvin; Tao, Chong; Jordan, Christopher D; Polik, William F; Reid, Scott A

2008-01-24

We have recorded stimulated emission pumping (SEP) spectra of the A1A' ' 1A' system of CHF, which reveal rich detail concerning the rovibronic structure of the 1A' state up to approximately 7000 cm-1 above the vibrationless level. Using several intermediate A1A' ' state levels, we obtained rotationally resolved spectra for 16 of the 33 levels observed in our previous single vibronic level (SVL) emission study (Fan et al., J. Chem. Phys. 2005, 123, 014314), in addition to one new level. An anharmonic effective Hamiltonian model poorly reproduces the term energies even with the improved set of data because of the extensive interactions among levels in a given polyad (p) having combinations of nu1, nu2, nu3, which satisfy the relationship p = 2nu1 + nu2 + nu3. However, the precise A rotational constants determined from the SEP data were invaluable in clarifying the assignments for these strongly perturbed levels, and the data are well reproduced using a multiresonance effective Hamiltonian model. The derived vibrational parameters are in good agreement with high level ab initio calculations. The experimental frequencies were combined with those of CDF to derive a harmonic force field and average (rz,r(z)e) structures for the ground state.

Microtubule-dependent path to the cell cortex for cytoplasmic dynein in mitotic spindle orientation

PubMed Central

Markus, Steven M.; Lee, Wei-Lih

2011-01-01

During animal development, microtubules (MTs) play a major role in directing cellular and subcellular patterning, impacting cell polarization and subcellular organization, thereby affecting cell fate determination and tissue architecture. In particular, when progenitor cells divide asymmetrically along an anterior-posterior or apical-basal axis, MTs must coordinate the position of the mitotic spindle with the site of cell division to ensure normal distribution of cell fate determinants and equal sequestration of genetic material into the two daughter cells. Emerging data from diverse model systems have led to the prevailing view that, during mitotic spindle positioning, polarity cues at the cell cortex signal for the recruitment of NuMA and the minus-end directed MT motor cytoplasmic dynein.1 The NuMA/dynein complex is believed to connect, in turn, to the mitotic spindle via astral MTs, thus aligning and tethering the spindle, but how this connection is achieved faithfully is unclear. Do astral MTs need to search for and then capture cortical NuMA/dynein? How does dynein capture the astral MTs emanating from the correct spindle pole? Recently, using the classical model of asymmetric cell division—budding yeast S. cerevisiae—we successfully demonstrated that astral MTs assume an active role in cortical dynein targeting, in that astral MTs utilize their distal plus ends to deliver dynein to the daughter cell cortex, the site where dynein activity is needed to perform its spindle alignment function. This observation introduced the novel idea that, during mitotic spindle orientation processes, polarity cues at the cell cortex may actually signal to prime the cortical receptors for MT-dependent dynein delivery. This model is consistent with the observation that dynein/dynactin accumulate prominently at the astral MT plus ends during metaphase in a wide range of cultured mammalian cells. PMID:22754610

Long baseline neutrino oscillation experiment at the AGS

NASA Astrophysics Data System (ADS)

Beavis, D.; Carroll, A.; Chiang, I.

1995-04-01

The authors present a design for a multidetector long baseline neutrino oscillation experiment at the BNL AGS. It has been approved by the BNL-HENP-PAC as AGS Experiment 889. The experiment will search for oscillations in the nu(sub mu) disappearance channel and the nu(sub mu) reversible reaction nu(sub e) appearance channel by means of four identical neutrino detectors located 1, 3, 24, and 68 km from the AGS neutrino source. Observed depletion of the nu(sub mu) flux (via quasi-elastic muon neutrino events, nu(sub mu)n yields mu(-)p) in the far detectors not attended by an observed proportional increase of the nu(sub e) flux (via quasi-elastic electron neutrino events, nu(sub e)n yields e(-)p) in those detectors will be prima facie evidence for the oscillation channel nu(sub mu) reversible reaction nu(sub tau). The experiment is directed toward exploration of the region of the neutrino oscillation parameters Delta m(exp 2) and sin(exp 2) 2 theta, suggested by the Kamiokande and IMB deep underground detectors but it will also explore a region more than two orders of magnitude larger than that of previous accelerator experiments. The experiment will run in a mode new to BNL. It will receive the fast extracted proton beam on the neutrino target approximately 20 hours per day when the AGS is not filling RHIC. A key aspect of the experimental design involves placing the detectors 1.5 degrees off the center line of the neutrino beam, which has the important advantage that the central value of the neutrino energy (approximately 1 GeV) and the beam spectral shape are, to a good approximation, the same in all four detectors. The proposed detectors are massive, imaging, water Cherenkov detectors similar in large part to the Kamiokande and IMB detectors. The design has profited from their decade-long experience, and from the detector designs of the forthcoming SNO and SuperKamiokande detectors.

Measuring temperature-dependent activation energy in thermally activated processes: a 2D Arrhenius plot method.

PubMed

Li, Jian V; Johnston, Steven W; Yan, Yanfa; Levi, Dean H

2010-03-01

Thermally activated processes are characterized by two key quantities, activation energy (E(a)) and pre-exponential factor (nu(0)), which may be temperature dependent. The accurate measurement of E(a), nu(0), and their temperature dependence is critical for understanding the thermal activation mechanisms of non-Arrhenius processes. However, the classic 1D Arrhenius plot-based methods cannot unambiguously measure E(a), nu(0), and their temperature dependence due to the mathematical impossibility of resolving two unknown 1D arrays from one 1D experimental data array. Here, we propose a 2D Arrhenius plot method to solve this fundamental problem. Our approach measures E(a) at any temperature from matching the first and second moments of the data calculated with respect to temperature and rate in the 2D temperature-rate plane, and therefore is able to unambiguously solve E(a), nu(0), and their temperature dependence. The case study of deep level emission in a Cu(In,Ga)Se(2) solar cell using the 2D Arrhenius plot method reveals clear temperature dependent behavior of E(a) and nu(0), which has not been observable by its 1D predecessors.

Computational study on the aminolysis of beta-hydroxy-alpha,beta-unsaturated ester via the favorable path including the formation of alpha-oxo ketene intermediate.

PubMed

Jin, Lu; Xue, Ying; Zhang, Hui; Kim, Chan Kyung; Xie, Dai Qian; Yan, Guo Sen

2008-05-15

The possible mechanisms of the aminolysis of N-methyl-3-(methoxycarbonyl)-4-hydroxy-2-pyridone (beta-hydroxy-alpha,beta-unsaturated ester) with dimethylamine are investigated at the hybrid density functional theory B3LYP/6-31G(d,p) level in the gas phase. Single-point computations at the B3LYP/6-311++G(d,p) and the Becke88-Becke95 1-parameter model BB1K/6-311++G(d,p) levels are performed for more precise energy predictions. Solvent effects are also assessed by single-point calculations at the integral equation formalism polarized continuum model IEFPCM-B3LYP/6-311++G(d,p) and IEFPCM-BB1K/6-311++G(d,p) levels on the gas-phase optimized geometries. Three possible pathways, the concerted pathway (path A), the stepwise pathway involving tetrahedral intermediates (path B), and the stepwise pathway via alpha-oxo ketene intermediate due to the participation of beta-hydroxy (path C), are taken into account for the title reaction. Moreover, path C includes two sequential processes. The first process is to generate alpha-oxo ketene intermediate via the decomposition of N-methyl-3-(methoxycarbonyl)-4-hydroxy-2-pyridone; the second process is the addition of dimethylamine to alpha-oxo ketene intermediate. Our results indicate that path C is more favorable than paths A and B both in the gas phase and in solvent (heptane). In path C, the first process is the rate-determining step, and the second process is revealed to be a [4+2] pseudopericyclic reaction without the energy barrier. Being independent of the concentration of amine, the first process obeys the first-order rate law.

Prevention of recrudescent malaria in nude mice by thymic grafting or by treatment with hyperimmune serum.

PubMed Central

Roberts, D W; Rank, R G; Weidanz, W P; Finerty, J F

1977-01-01

Nude mice died when infected with the normally avirulent malarial parasite Plasmodium berghei yoelii. Furthermore, malaria recrudesced in Nu/Nu mice after the termination of acute disease by treatment with clindamycin. Recrudescence was not observed in Nu/Nu mice that had been grafted with thymic tissue or treated with hyperimmune serum. Mice mad B cell deficient by treatment with anti-mu-chain serum also died when infected with P. berghei yoelii. The data suggest that a crucial role of the thymus in preventing recrudescent malaria in this model system is to provide a helper function in the production of protective antibody. PMID:330396

Evaluation and thermodynamic calculation of ureolytic magnesium ammonium phosphate precipitation from UASB effluent at pilot scale.

PubMed

Desmidt, E; Ghyselbrecht, K; Monballiu, A; Verstraete, W; Meesschaert, B D

2012-01-01

The removal of phosphate as magnesium ammonium phosphate (MAP, struvite) has gained a lot of attention. A novel approach using ureolytic MAP crystallization (pH increase by means of bacterial ureases) has been tested on the anaerobic effluent of a potato processing company in a pilot plant and compared with NuReSys(®) technology (pH increase by means of NaOH). The pilot plant showed a high phosphate removal efficiency of 83 ± 7%, resulting in a final effluent concentration of 13 ± 7 mg · L(-1) PO(4)-P. Calculating the evolution of the saturation index (SI) as a function of the remaining concentrations of Mg(2+), PO(4)-P and NH(4)(+) during precipitation in a batch reactor, resulted in a good estimation of the effluent PO(4)-P concentration of the pilot plant, operating under continuous mode. X-ray diffraction (XRD) analyses confirmed the presence of struvite in the small single crystals observed during experiments. The operational cost for the ureolytic MAP crystallization treating high phosphate concentrations (e.g. 100 mg · L(-1) PO(4)-P) was calculated as 3.9 € kg(-1) P(removed). This work shows that the ureolytic MAP crystallization, in combination with an autotrophic nitrogen removal process, is competitive with the NuReSys(®) technology in terms of operational cost and removal efficiency but further research is necessary to obtain larger crystals.

78 FR 78353 - NuStar Crude Oil Pipeline L.P.; Notice of Petiton for Declaratory Order

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

... transport additional Eagle Ford shale crude. Among other things, NuStar seeks approval of its transportation... Online links at http://www.ferc.gov . To facilitate electronic service, persons with Internet access who...

Inside NuSTAR Nose Cone

NASA Image and Video Library

2012-03-02

A spacecraft technician is performing closeout work inside the fairing that will be installed around NASA Nuclear Spectroscopic Telescope Array NuSTAR spacecraft in a processing facility at Vandenberg Air Force Base in California.

Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells

PubMed Central

Bhattacharya, Sujoy; Ray, Ramesh M.; Johnson, Leonard R.

2014-01-01

Homeostasis of the gastrointestinal epithelium is dependent upon a balance between cell proliferation and apoptosis. Cyclin-dependent kinases (Cdks) are well known for their role in cell proliferation. Previous studies from our group have shown that polyamine-depletion of intestinal epithelial cells (IEC-6) decreases cyclin-dependent kinase 2 (Cdk2) activity, increases p53 and p21Cip1 protein levels, induces G1 arrest, and protects cells from camptothecin (CPT)-induced apoptosis. Although emerging evidence suggests that members of the Cdk family are involved in the regulation of apoptosis, their roles directing apoptosis of IEC-6 cells are not known. In this study, we report that inhibition of Cdk1, 2, and 9 (with the broad range Cdk inhibitor, AZD5438) in proliferating IEC-6 cells triggered DNA damage, activated p53 signaling, inhibited proliferation, and induced apoptosis. By contrast, inhibition of Cdk2 (with NU6140) increased p53 protein and activity, inhibited proliferation, but had no effect on apoptosis. Notably, AZD5438 sensitized, whereas, NU6140 rescued proliferating IEC-6 cells from CPT-induced apoptosis. However, in colon carcinoma (Caco2) cells with mutant p53, treatment with either AZD5438 or NU6140 blocked proliferation, albeit more robustly with AZD5438. Both Cdk inhibitors induced apoptosis in Caco2 cells in a p53-independent manner. In serum starved quiescent IEC-6 cells, both AZD5438 and NU6140 decreased TNF- /CPT-induced activation of p53 and, consequently, rescued cells from apoptosis, indicating that sustained Cdk activity is required for apoptosis of quiescent cells. Furthermore, AZD5438 partially reversed the protective effect of polyamine depletion whereas NU6140 had no effect. Together, these results demonstrate that Cdks possess opposing roles in the control of apoptosis in quiescent and proliferating cells. In addition, Cdk inhibitors uncouple proliferation from apoptosis in a p53-dependent manner. PMID:24242917

Light, rest mass and electric charge quanta all formed by neutrinos?

NASA Astrophysics Data System (ADS)

Chen, Shao-Guang

In high energy physics experiments the electric charge and rest mass of particles can commonly transform into the photons, vice versa. Its reason QFT can only give a vague answer: based on the particle creation and annihilation operators. There are not more clear answers or conjecture? At least, light, electric charge and rest mass should have a collective structure component, if not, the transformation is unable understanding. An elementary answer is that neutrino and antineutrino as their collective structure component. In the paper ‘Chen Qiliang & Wang Bin, The formation and characteristics of Chen Shaoguang's formula, China Science &Technology Overview 127101-103 (2011)’, the lowest energy state vertical polarized left spin 1/2 neutrino and right spin 1/2 antineutrino are just the left, right advance unit quanta la _{0}nuυ, ra nuυ _{0} and left, right back unit quanta lb (0) nuυ, rb nuυ (0) , it again compose into spin 1 unit photon la-ra _{0}nuυnuυ _{0} and back-photon lb-rb (0) nuυnuυ (0) , spin 0 unit rest mass ra-rb nuυ _{0}nuυ (0) and anti-mass la-lb _{0}nuυ (0) nuυ, spin 0 unit positive charge la-rb _{0}nuυnuυ (0) and negative charge ra-lb nuυ _{0} (0) nuυ. The physical vacuum is the even collocation of non-combinational nuυ _{0} or _{0}nuυ. It accord to the high energy physics experimental results of the transformation among the photons, masses quanta and charges quanta. In my paper ‘Quanta turn-advance ism, China Science && Technology Overview 131 192-210 (2011)’, QFT four-dimensional uncertainty principle and momentum-energy conservation law had been generalized as a five-dimensional equations: de Broglie wavelength as a position vector \\underline{q}= (i c t, r, s), momentum \\underline{P} = (i E / c, P, U c), \\underline{q} = i h / \\underline{P}, \\underline{q} \\underline{q} = 0, \\underline{P} \\underline{P} = 0, Sigma∑ \\underline{P} = \\underline{P} (0) . The five-dimensional time-space-spin had been quantized as a non-dot model basic cell. QFT is no longer with divergence difficulty by the non-dot model. It is mathematically easy that from five-dimensional equations deduce out the Dirac, Klein-Gordan, Maxwell equations and Lorentz force formula, but appear some new results. The interactions between _{0}nuυ, nuυ _{0}, (0) nuυ, nuυ (0) , i.e., force f = ± ( h c / 2 r (3) ) r cos thetaθ for r not equal to 0 and f = 0 for r = 0, f as the magnetic force makes the photons, rest mass and charge quanta automatically come into being and stabilize. CMB photon can be produced from many spin 1 unit photons by its statistical attraction. The explanation of abnormal magnetic moment and Lamb shift is more natural and simple only with the spin — the conjunction between turn and advance. Many testable results had been obtained. The la, ra, lb, rb exist on each direction of i, j, k, its mathematical describe is with five-dimension unit place vector \\underline{q} = (i c t, r, s) and momentum \\underline{P} = (i E t /c, P, U c). The left spin s is real number and right spin s is imaginary number, positive direction advance r is i (or j, k) and back direction advance r is -i (or -j, -k). For four la, ra, lb, rb the t and E are all the same, but P only absolute value are the same and turn- quantity U with the external interaction has the difference of left turn U = e and right turn U = \\underline{e}. Such as in i direction we get that la: \\underline{q} = (i c t, r, 0, 0, s ), \\underline{P} = (i E/c, P, 0, 0 , e c); ra: \\underline{q} = (i c t, r, 0, 0, i s), \\underline{P} = (i E/c, P, 0, 0, \\underline{e} c); lb: \\underline{q}=(i c t, - r, 0, 0, -s), \\underline{P} = (i E/c, -P, 0, 0, -e c); {rb}: \\underline{q} = (i c t, - r, 0, 0, - i s), \\underline{P} = (i E/c, -P, 0, 0, - \\underline{e} c); la-ra : \\underline{q} = (i 2 c t, 2 r, (1+i) s), \\underline{P} = ( i 2 E/c, 2 P, (e + \\underline{e}) c); lb-rb : \\underline{q} = (i 2 c t,-2 r, -(1 + i) s), \\underline{P} = (i 2 E/c, -2 P, -(e + \\underline{e}) c); ra-rb: \\underline{q} = (i c 2 t, 0, (i - i) s ), \\underline{P} = (i 2 E/c, 0, (\\underline{e} - \\underline{e}) c); la-lb: \\underline{q} = (i 2 c t, 0, (s - s)), \\underline{P} = (i 2 E/c, 0, (e - e) c); la-rb : \\underline{q} = (i c 2 t, 0, ( 1 - i ) s), \\underline{P} = (i 2 E/c, 0 , (e - \\underline{e}) c); ra-lb: \\underline{q} = (i 2 c t, 0, (i - 1 ) s), \\underline{P} = (i 2 E/c, 0, (\\underline{e} - e) c). Because of the vertical polarization of neutrinos, when momentum in reverse the turn-quantity also from left to right or from right to left, we get: \\underline{e} = - e. The turn-quantity U of la-rb or ra-lb equal to 2 e or -2 e, so that the turn-quantity U is just the electric quantity q, also is the reason that it call as the positive or negative charge quantum. The ra-rb or la-lb to be called the rest mass or the anti-mass quantum for its momentum and turn-quantity all equal to zero, it is at the absolute rest and absolute non-external-interaction (the gravitation caused by the ra or la inside bodies). The la-ra or lb-rb has the momentum 2 P or - 2 P and turn-quantity (e + \\underline{e}) or - (e + \\underline{e}) and is a pure momentum without external-interaction (the ra or la is the momentum with external-interaction), so to be called as the photon or back-photon. In the right turn Milky Way the number of right turn ra-rb much exceed the number of left turn la-lb, so ra-rb as the rest mass and la-lb as the anti-mass, and the physical vacuum is composed by right turn ra. But the number of la-rb and ra-lb at the same, who call as negative charge all ok, I take ra-lb as the negative charge. In a simple model the fifth-dimensional turn-quantity U c with the momentum P average share the general energy for ra , la, la-ra and lb-rb, but for the charge quanta la-rb and ra-lb the general energy all in the electric quantity q. For ra-rb quantum though the external-interaction of ra and rb to be counteracted and leads to its turn-quantity U = (e - e) = 0, but the general energy unable vanish and corresponding to the absolute values of turn-quantity [ e ] + [ - e ]= [ U ]. So the absolute value of turn-quantity [ U ] is called as the rest mass. The recombination: la-ra + lb-rb = la+ ra + lb + rb = la-lb + ra-rb = la+ ra +lb + rb = la-rb +ra-lb accord to the transformation among the photons, masses quanta and charges quanta. Furthermore, we get the light, charge and rest mass all come from the same ‘non-dot model’ basic cell turn-advance quanta. From \\underline{P} • \\underline{P} = 0 we get the rest mass of la or ra: m (0) = [ e ] = [ P/c ] = ±± (1/2 (1/2) ) E/c (2) ; the electric quantity of unit charge quanta la-rb or ra-lb q _{0} = 2 (1/2) 2 q (0) , q (0) is the electric quantity of unit turn-advance quanta. The ±± symbol shows that when m (0) to take positive value then the neutrinos and antineutrinos all have positive and negative energy level, when the energy E to take positive value then e to take positive value then \\underline{e} must take negative value. In the quantized inconsecutive time-space-spin with momentum and turn-quantity as the coordinates drawing the momentum-turn graphics are some points with certain distance. The rest mass m _{0} is the lowest energy state advance-back neutrinos pair ra-rb, when j direction have 2n ra or rb the i , k directions must have (2n-1), (2n+1) ra or rb for i, j, k three directions all matching into pair to eliminate the external interaction of electric quantity q (0) in ra. The spatial rest mass is: (n) m _{0} = (2n-1) 2n (2n+1) m (0) = 6, 60, 210, 504, 990 and 1716 m (0) . According to the uncertainty principle n large rest mass layer is more little and at the inside layer of particle. The spatial unit charge quanta e or \\underline{e} are composed by nine one-dimensional unit charge quanta la-rb or ra-lb because of the vertical polarization at each spatial direction there is only three states: the left, the right and the middle of left-right balance.

Methane concentration and isotopic composition measurements with a mid-infrared quantum-cascade laser

NASA Technical Reports Server (NTRS)

Kosterev, A. A.; Curl, R. F.; Tittel, F. K.; Gmachl, C.; Capasso, F.; Sivco, D. L.; Baillargeon, J. N.; Hutchinson, A. L.; Cho, A. Y.

1999-01-01

A quantum-cascade laser operating at a wavelength of 8.1 micrometers was used for high-sensitivity absorption spectroscopy of methane (CH4). The laser frequency was continuously scanned with current over more than 3 cm-1, and absorption spectra of the CH4 nu 4 P branch were recorded. The measured laser linewidth was 50 MHz. A CH4 concentration of 15.6 parts in 10(6) ( ppm) in 50 Torr of air was measured in a 43-cm path length with +/- 0.5-ppm accuracy when the signal was averaged over 400 scans. The minimum detectable absorption in such direct absorption measurements is estimated to be 1.1 x 10(-4). The content of 13CH4 and CH3D species in a CH4 sample was determined.

Cortical thinness and volume differences associated with marijuana abuse in emerging adults.

PubMed

Mashhoon, Y; Sava, S; Sneider, J T; Nickerson, L D; Silveri, M M

2015-10-01

The prevalence of marijuana (MJ) use among youth and its legalization for medical or recreational use has intensified public health endeavors of understanding MJ effects on brain structure and function. Studies indicate that MJ use is related to impaired cognitive performance, and altered functional brain activation and chemistry in adolescents and adults, but MJ effects on brain morphology in emerging adults are less understood. Fifteen MJ users (age 21.8±3.6, 2 females) and 15 non-user (NU) participants (age 22.3±3.5, 2 females) were included, demographically matched on age, education and alcohol use. High-resolution structural MR images were acquired at 3Tesla. Cortical thickness (CT) and volumetric analyses were performed using Freesurfer. A priori regions of interest (ROI) included orbitofrontal and cingulate cortices, amygdala, hippocampus and thalamus. Whole brain CT analysis did not result in significant group differences in a priori ROIs but revealed MJ users had significantly less CT (i.e., thinness) in right fusiform gyrus (rFG) compared to NU (p<0.05). Thalamic volume was significantly smaller in MJ users compared to NU (right, p=0.05; left, p=0.01) and associated with greater non-planning (p<0.01) and overall impulsivity (p=0.04). There were no other group differences. RFG cortical thinness and smaller thalamic volume in emerging adults is associated with MJ abuse. Furthermore, smaller thalamic volume associated with greater impulsivity contributes to growing evidence that the thalamus is neurobiologically perturbed by MJ use. Collectively, altered thalamic and rFG structural integrity may interfere with their known roles in regulating visuoperceptual and object information processing. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Evaluation of a Mobile Phone Image-Based Dietary Assessment Method in Adults with Type 2 Diabetes.

PubMed

Rollo, Megan E; Ash, Susan; Lyons-Wall, Philippa; Russell, Anthony W

2015-06-17

Image-based dietary records have limited evidence evaluating their performance and use among adults with a chronic disease. This study evaluated the performance of a 3-day mobile phone image-based dietary record, the Nutricam Dietary Assessment Method (NuDAM), in adults with type 2 diabetes mellitus (T2DM). Criterion validity was determined by comparing energy intake (EI) with total energy expenditure (TEE) measured by the doubly-labelled water technique. Relative validity was established by comparison to a weighed food record (WFR). Inter-rater reliability was assessed by comparing estimates of intake from three dietitians. Ten adults (6 males, age: 61.2 ± 6.9 years old, BMI: 31.0 ± 4.5 kg/m(2)) participated. Compared to TEE, mean EI (MJ/day) was significantly under-reported using both methods, with a mean ratio of EI:TEE 0.76 ± 0.20 for the NuDAM and 0.76 ± 0.17 for the WFR. Correlations between the NuDAM and WFR were mostly moderate for energy (r = 0.57), carbohydrate (g/day) (r = 0.63, p < 0.05), protein (g/day) (r = 0.78, p < 0.01) and alcohol (g/day) (rs = 0.85, p < 0.01), with a weaker relationship for fat (g/day) (r = 0.24). Agreement between dietitians for nutrient intake for the 3-day NuDAM (Intra-class Correlation Coefficient (ICC) = 0.77-0.99) was lower when compared with the 3-day WFR (ICC = 0.82-0.99). These findings demonstrate the performance and feasibility of the NuDAM to assess energy and macronutrient intake in a small sample. Some modifications to the NuDAM could improve efficiency and an evaluation in a larger group of adults with T2DM is required.

A chimeric protein composed of NuMA fused to the DNA binding domain of LANA is sufficient for the ori-P-dependent DNA replication

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ohsaki, Eriko; Ueda, Keiji, E-mail: kueda@virus.me

The Kaposi's sarcoma-associated herpesvirus (KSHV) genome is stably maintained in KSHV-infected PEL cell lines during cell division. We previously showed that accumulation of LANA in the nuclear matrix fraction could be important for the latent DNA replication, and that the functional significance of LANA should be its recruitment of ori-P to the nuclear matrix. Here, we investigated whether the forced localization of the LANA-DNA binding domain (DBD) to the nuclear matrix facilitated ori-P-containing plasmid replication. We demonstrated that chimeric proteins constructed by fusion of LANA DBD with the nuclear mitotic apparatus protein (NuMA), which is one of the components ofmore » the nuclear matrix, could bind with ori-P and enhance replication of an ori-P-containing plasmid, compared with that in the presence of DBD alone. These results further suggested that the ori-P recruitment to the nuclear matrix through the binding with DBD is important for latent viral DNA replication. - Highlights: •KSHV replication in latency depends on LANA localization to the nuclear matrix. •LANA DBD was fused with NuMA, a nuclear matrix protein, at the N- and C-terminus. •NuMA-DBD was in the nuclear matrix and supported the ori-P dependent replication. •LANA in the nuclear matrix should be important for the KSHV replication in latency.« less

Final Steps in Mating NuSTAR to its Rocket

NASA Image and Video Library

2012-02-23

Inside an environmental enclosure at Vandenberg Air Force Base processing facility in California, technicians complete the final steps in mating NASA Nuclear Spectroscopic Telescope Array NuSTAR and its Orbital Sciences Pegasus XL rocket.

Molecular Structures, Vibrational Spectroscopy, and Normal-Mode Analysis of M(2)(C&tbd1;CR)(4)(PMe(3))(4) Dimetallatetraynes. Observation of Strongly Mixed Metal-Metal and Metal-Ligand Vibrational Modes.

PubMed

John, Kevin D.; Miskowski, Vincent M.; Vance, Michael A.; Dallinger, Richard F.; Wang, Louis C.; Geib, Steven J.; Hopkins, Michael D.

1998-12-28

The nature of the skeletal vibrational modes of complexes of the type M(2)(C&tbd1;CR)(4)(PMe(3))(4) (M = Mo, W; R = H, Me, Bu(t)(), SiMe(3)) has been deduced. Metrical data from X-ray crystallographic studies of Mo(2)(C&tbd1;CR)(4)(PMe(3))(4) (R = Me, Bu(t)(), SiMe(3)) and W(2)(C&tbd1;CMe)(4)(PMe(3))(4) reveal that the core bond distances and angles are within normal ranges and do not differ in a statistically significant way as a function of the alkynyl substituent, indicating that their associated force constants should be similarly invariant among these compounds. The crystal structures of Mo(2)(C&tbd1;CSiMe(3))(4)(PMe(3))(4) and Mo(2)(C&tbd1;CBu(t)())(4)(PMe(3))(4) are complicated by 3-fold disorder of the Mo(2) unit within apparently ordered ligand arrays. Resonance-Raman spectra ((1)(delta-->delta) excitation, THF solution) of Mo(2)(C&tbd1;CSiMe(3))(4)(PMe(3))(4) and its isotopomers (PMe(3)-d(9), C&tbd1;CSiMe(3)-d(9), (13)C&tbd1;(13)CSiMe(3)) exhibit resonance-enhanced bands due to a(1)-symmetry fundamentals (nu(a) = 362, nu(b) = 397, nu(c) = 254 cm(-)(1) for the natural-abundance complex) and their overtones and combinations. The frequencies and relative intensities of the fundamentals are highly sensitive to isotopic substitution of the C&tbd1;CSiMe(3) ligands, but are insensitive to deuteration of the PMe(3) ligands. Nonresonance-Raman spectra (FT-Raman, 1064 nm excitation, crystalline samples) for the Mo(2)(C&tbd1;CSiMe(3))(4)(PMe(3))(4) compounds and for Mo(2)(C&tbd1;CR)(4)(PMe(3))(4) (R = H, D, Me, Bu(t)(), SiMe(3)) and W(2)(C&tbd1;CMe)(4)(PMe(3))(4) exhibit nu(a), nu(b), and nu(c) and numerous bands due to alkynyl- and phosphine-localized modes, the latter of which are assigned by comparisons to FT-Raman spectra of Mo(2)X(4)L(4) (X = Cl, Br, I; L = PMe(3), PMe(3)-d(9))(4) and Mo(2)Cl(4)(AsMe(3))(4). Valence force-field normal-coordinate calculations on the model compound Mo(2)(C&tbd1;CH)(4)P(4), using core force constants transferred from a calculation on Mo(2)Cl(4)P(4), show that nu(a), nu(b), and nu(c) arise from modes of strongly mixed nu(Mo(2)), nu(MoC), and lambda(MoCC) character. The relative intensities of the resonance-Raman bands due to nu(a), nu(b), and nu(c) reflect, at least in part, their nu(M(2)) character. In contrast, the force field shows that mixing of nu(M(2)) and nu(C&tbd1;C) is negligible. The three-mode mixing is expected to be a general feature for quadruply bonded complexes with unsaturated ligands.

Resistance distribution in the hopping percolation model.

PubMed

Strelniker, Yakov M; Havlin, Shlomo; Berkovits, Richard; Frydman, Aviad

2005-07-01

We study the distribution function P (rho) of the effective resistance rho in two- and three-dimensional random resistor networks of linear size L in the hopping percolation model. In this model each bond has a conductivity taken from an exponential form sigma proportional to exp (-kappar) , where kappa is a measure of disorder and r is a random number, 0< or = r < or =1 . We find that in both the usual strong-disorder regime L/ kappa(nu) >1 (not sensitive to removal of any single bond) and the extreme-disorder regime L/ kappa(nu) <1 (very sensitive to such a removal) the distribution depends only on L/kappa(nu) and can be well approximated by a log-normal function with dispersion b kappa(nu) /L , where b is a coefficient which depends on the type of lattice, and nu is the correlation critical exponent.

Uniting of NuSTAR Spacecraft and Rocket

NASA Image and Video Library

2012-02-23

Inside an environmental enclosure at Vandenberg Air Force Base processing facility in California, solar panels line the sides of NASA Nuclear Spectroscopic Telescope Array NuSTAR, which was just joined to the Orbital Sciences Pegasus XL rocket.

Solar neutrino flux at keV energies

NASA Astrophysics Data System (ADS)

Vitagliano, Edoardo; Redondo, Javier; Raffelt, Georg

2017-12-01

We calculate the solar neutrino and antineutrino flux in the keV energy range. The dominant thermal source processes are photo production (γ e→ e νbar nu), bremsstrahlung (e+Ze→ Ze+e+νbar nu), plasmon decay (γ→νbar nu), and νbar nu emission in free-bound and bound-bound transitions of partially ionized elements heavier than hydrogen and helium. These latter processes dominate in the energy range of a few keV and thus carry information about the solar metallicity. To calculate their rate we use libraries of monochromatic photon radiative opacities in analogy to a previous calculation of solar axion emission. Our overall flux spectrum and many details differ significantly from previous works. While this low-energy flux is not measurable with present-day technology, it could become a significant background for future direct searches for keV-mass sterile neutrino dark matter.

Effects of the Neutrino B-term on SLepton Mixing and Electric Dipole Moments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farzan, Y

2003-10-10

The supersymmetric standard model with right-handed neutrino supermultiplets generically contains a soft supersymmetry breaking mass term: {delta}L = 1/2B{sub {nu}}M{tilde {nu}}{sub R}{tilde {nu}}{sub R}. The authors call this operator the ''neutrino B-term''. We show that the neutrino B-term can give the dominant effects from the neutrino sector to lepton flavor violating processes and to lepton electric dipole moments.

Long baseline neutrino oscillation experiment at the AGS. Physics design report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beavis, D.; Carroll, A.; Chiang, I.

1995-04-01

The authors present a design for a multi-detector long baseline neutrino oscillation experiment at the BNL AGS. It has been approved by the BNL-HENP-PAC as AGS Experiment 889. The experiment will search for oscillations in the {nu}{sub {mu}}, disappearance channel and the {nu}{sub {mu}} {leftrightarrow} {nu}{sub e} appearance channel by means of four identical neutrino detectors located 1, 3, 24, and 68km from the AGS neutrino source. Observed depletion of the {nu}{sub {mu}} flux (via quasi-elastic muon neutrino events, {nu}{sub {mu}}n {yields} {mu}{sup {minus}}p) in the far detectors not attended by an observed proportional increase of the {nu}{sub e} fluxmore » (via quasi-elastic electron neutrino events, {nu}{sub e}n {yields} e{sup {minus}}p) in those detectors will be prima facie evidence for the oscillation channel {nu}{sub {mu}} {leftrightarrow} {nu}{sub {tau}}. The experiment is directed toward exploration of the region of the neutrino oscillation parameters {Delta}m{sup 2} and sin{sup 2}2{theta}, suggested by the Kamiokande and IMB deep underground detectors but it will also explore a region more than two orders of magnitude larger than that of previous accelerator experiments. The experiment will run in a mode new to BNL. It will receive the fast extracted proton beam on the neutrino target approximately 20 hours per day when the AGS is not filling RHIC. A key aspect of the experimental design involves placing the detectors 1.5 degrees off the center line of the neutrino beam, which has the important advantage that the central value of the neutrino energy ({approx} 1 GeV) and the beam spectral shape are, to a good approximation, the same in all four detectors. The proposed detectors are massive, imaging, water Cherenkov detectors similar in large part to the Kamiokande and IMB detectors. The design has profited from their decade-long experience, and from the detector designs of the forthcoming SNO and SuperKamiokande detectors.« less

NuSTAR Inches Toward its Rocket

NASA Image and Video Library

2012-02-23

At Vandenberg Air Force Base processing facility in California, the separation ring on the aft end of NASA Nuclear Spectroscopic Telescope Array NuSTAR, at right, inches its way toward the third stage of an Orbital Sciences Pegasus XL rocket.

KSC-2012-3027

NASA Image and Video Library

2012-05-22

VANDENBERG AFB, Calif. – Technicians install the second half of the payload fairing over the NuSTAR spacecraft as they continue to process the spacecraft and its Pegasus rocket for launch. NuSTAR stands for Nuclear Spectroscopic Telescope Array. Photo credit: NASA/Randy Beaudoin

KSC-2012-3028

NASA Image and Video Library

2012-05-22

VANDENBERG AFB, Calif. – Technicians install the second half of the payload fairing over the NuSTAR spacecraft as they continue to process the spacecraft and its Pegasus rocket for launch. NuSTAR stands for Nuclear Spectroscopic Telescope Array. Photo credit: NASA/Randy Beaudoin

KSC-2012-3023

NASA Image and Video Library

2012-05-22

VANDENBERG AFB, Calif. – Technicians install one half of the payload fairing over the NuSTAR spacecraft as they continue to process the spacecraft and its Pegasus rocket for launch. NuSTAR stands for Nuclear Spectroscopic Telescope Array. Photo credit: NASA/Randy Beaudoin

KSC-2012-3026

NASA Image and Video Library

2012-05-22

VANDENBERG AFB, Calif. – Technicians install the second half of the payload fairing over the NuSTAR spacecraft as they continue to process the spacecraft and its Pegasus rocket for launch. NuSTAR stands for Nuclear Spectroscopic Telescope Array. Photo credit: NASA/Randy Beaudoin

KSC-2012-3022

NASA Image and Video Library

2012-05-22

VANDENBERG AFB, Calif. – Technicians install one half of the payload fairing over the NuSTAR spacecraft as they continue to process the spacecraft and its Pegasus rocket for launch. NuSTAR stands for Nuclear Spectroscopic Telescope Array. Photo credit: NASA/Randy Beaudoin

KSC-2012-3029

NASA Image and Video Library

2012-05-22

VANDENBERG AFB, Calif. – Technicians install the second half of the payload fairing over the NuSTAR spacecraft as they continue to process the spacecraft and its Pegasus rocket for launch. NuSTAR stands for Nuclear Spectroscopic Telescope Array. Photo credit: NASA/Randy Beaudoin

KSC-2012-3021

NASA Image and Video Library

2012-05-22

VANDENBERG AFB, Calif. – Technicians install one half of the payload fairing over the NuSTAR spacecraft as they continue to process the spacecraft and its Pegasus rocket for launch. NuSTAR stands for Nuclear Spectroscopic Telescope Array. Photo credit: NASA/Randy Beaudoin

KSC-2012-3024

NASA Image and Video Library

2012-05-22

VANDENBERG AFB, Calif. – Technicians install one half of the payload fairing over the NuSTAR spacecraft as they continue to process the spacecraft and its Pegasus rocket for launch. NuSTAR stands for Nuclear Spectroscopic Telescope Array. Photo credit: NASA/Randy Beaudoin

KSC-2012-3030

NASA Image and Video Library

2012-05-22

VANDENBERG AFB, Calif. – A technicians checks the installation of the payload fairing over the NuSTAR spacecraft as processing continues for the spacecraft and its Pegasus rocket for launch. NuSTAR stands for Nuclear Spectroscopic Telescope Array. Photo credit: NASA/Randy Beaudoin

Preoperative depressed mood and perioperative heart rate variability in patients with hepatic cancer.

PubMed

Kim, Eun-Hee; Park, Jin-Hyoung; Lee, Sangmin M; Gwak, Mi-Sook; Kim, Gaab-Soo; Kim, Myung-Hee

2016-12-01

How perioperative heart rate variability (HRV) indices differ according to the anxiety or depressed mood of patients scheduled to undergo a major surgical procedure for cancer. Prospective observational study. Operating room. Forty-one male patients between 40 and 70 years of age with hepatocellular carcinoma were included in the final analysis. HRV was measured on the day before surgery (T1), impending anesthesia (T2), and after anesthetic induction (T3). Preoperative anxiety and depressed mood of all patients were evaluated using the State-Trait Anxiety Inventory and Self-Rating Depression Scale (SDS). HRV was significantly different among T1, T2, and T3. At T2, high frequency (HF) (normalized units of HF [nuHF]) was decreased and low frequency (LF) (normalized units of LF) and LF/HF were increased compared with those at T1 and T3. In the subgroup analysis between high and low SDS groups, high SDS group showed significantly decreased nuHF (P = .035), increased nuLF (P = .039), and increased LF/HF (P = .020) compared to low SDS group at T1. However, these values at T2 and T3 were not different between 2 groups. In analysis within the groups, low SDS group showed significant differences in nuHF, nuLF, and LF/HF among T1, T2, and T3 (P < .05, respectively), but no changes in these values were observed in high SDS group among the 3 different time points. HRV decreased significantly immediately before anesthesia and recovered to baseline with anesthetic induction. Preoperative, more depressed patients showed increased sympathetic tone at baseline and blunted response to impending anesthesia on the HRV measurements. Copyright © 2016 Elsevier Inc. All rights reserved.

The International Symposium on Equatorial Aeronomy (10th) Held in Antalya, Turkey on May 17-23, 2000

DTIC Science & Technology

2000-10-23

Paulo - FAPESP, and the Programa de Nicleos de Excelencia - PRONEX. Nu- merical values for the model tides were taken from the GSWM homepage at http...FAPESP, and the Programa de Nilcleos de Excel~ncia-PRONEX. References Batista, P. P., B. R. Clemesha, I. S. Batista and D. M. Simonich, Characteristics...based on M. J. Taylor, H. Takahashi, D. Gobbi, and A. Chemical and Dynamical Processes, Tarun Kumar F. de Medeiros. Pant and R. SRIDHARAN. 13. 17:30-17

Measuring B{sup {+-}}{yields}{tau}{sup {+-}}{nu} and B{sub c}{sup {+-}}{yields}{tau}{sup {+-}}{nu} at the Z peak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akeroyd, A. G.; Chen, C.H.; National Center for Theoretical Sciences, Taiwan

2008-06-01

The measurement of B{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} at the B factories provides important constraints on the parameter tan{beta}/m{sub H{sup {+-}}} in the context of models with two Higgs doublets. Limits on this decay from e{sup +}e{sup -} collisions at the Z peak were sensitive to the sum of B{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} and B{sub c}{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}}. Because of the possibly sizeable contribution from B{sub c}{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} we suggest that a signal for this combination might be observed if the CERN LEP L3 Collaboration used its total data of {approx}3.6x10{sup 6} hadronic decays of the Z boson.more » Moreover, we point out that a future linear collider operating at the Z peak (Giga Z option) could constrain tan{beta}/m{sub H{sup {+-}}} from the sum of these processes with a precision comparable to that anticipated at proposed high luminosity B factories from B{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} alone.« less

The NuRD complex component p66 suppresses photoreceptor neuron regeneration in planarians.

PubMed

Vásquez-Doorman, Constanza; Petersen, Christian P

2016-06-01

Regeneration involves precise control of cell fate to produce an appropriate complement of tissues formed within a blastema. Several chromatin-modifying complexes have been identified as required for regeneration in planarians, but it is unclear whether this class of molecules uniformly promotes the production of differentiated cells. We identify a function for p66, encoding a DNA-binding protein component of the NuRD (nucleosome remodeling and deacetylase) complex, as well as the chromodomain helicase chd4, in suppressing production of photoreceptor neurons (PRNs) in planarians. This suppressive effect appeared restricted to PRNs because p66 inhibition did not influence numbers of eye pigment cup cells (PCCs) and decreased numbers of brain neurons and epidermal progenitors. PRNs from p66(RNAi) animals differentiated with some abnormalities but nonetheless produced arrestin+ projections to the brain. p66 inhibition produced excess ovo+otxA+ PRN progenitors without affecting numbers of ovo+otxA- PCC progenitors, and ovo and otxA were each required for the p66(RNAi) excess PRN phenotype. Together these results suggest that p66 acts through the NuRD complex to suppress PRN production by limiting expression of lineage-specific transcription factors.

Processing of higher count rates in Troitsk nu-mass experiment

NASA Astrophysics Data System (ADS)

Nozik, Alexander; Chernov, Vaslily

2018-04-01

In this article we give a short outline of current status of search for sterile neutrinos with masses up to 4 keV in "Troitsk nu-mass experiment". We also discuss major sources of systematic uncertainties and methods to lower them.

Comparison of VATS and Robotic Approaches For Clinical Stage I and II NSCLC Using the STS Database

PubMed Central

Louie, Brian E.; Wilson, Jennifer L.; Kim, Sunghee; Cerfolio, Robert J.; Park, Bernard J.; Farivar, Alexander S.; Vallières, Eric; Aye, Ralph W.; Burfeind, William R.; Block, Mark I.

2016-01-01

Background Data from selected centers show that robotic lobectomy (RL) is safe, effective and has comparable 30-day mortality to video assisted lobectomy (VATS). However, widespread adoption of RL is controversial. We used the STS-GTS-Database to evaluate quality metrics for these two minimally invasive lobectomy techniques. Methods A database query for primary clinical stage I or II NSCLC at high volume centers from 2009 to 2013 identified 1,220 RLs and 12,378 VATS. Quality metrics evaluated included operative morbidity, 30-day mortality and nodal upstaging (NU), defined as cN0 to pN1. Multivariable logistic regression was used to evaluate NU. Results RL patients were older, less active, less likely to be an ever smoker, and had higher BMI (all p<0.05). They were also more likely to have coronary heart disease or hypertension (all p<0.001) and to have had preoperative mediastinal staging (p<0.0001). RL operative times were longer (median 186 vs 173 min, p<0.001); all other operative parameters were similar. All postoperative outcomes were similar including complications and 30-day mortality (RL 0.6% vs VATS 0.8%, p=0.4). Median length of stay was 4 days for both, but a higher proportion of RLs stayed < 4 days: 48% vs 39%, p<0.001. NU overall was similar (p=0.6), but with trends favoring VATS in the cT1b group, and RL in the cT2a group. Conclusions RL patients had more co-morbidities and RL operative times were longer, but quality outcome measures including complications, hospital stay, 30-day mortality, and NU suggest RL and VATS are equivalent. PMID:27209613

NEMA NU 4-Optimized Reconstructions for Therapy Assessment in Cancer Research with the Inveon Small Animal PET/CT System.

PubMed

Lasnon, Charline; Dugue, Audrey Emmanuelle; Briand, Mélanie; Blanc-Fournier, Cécile; Dutoit, Soizic; Louis, Marie-Hélène; Aide, Nicolas

2015-06-01

We compared conventional filtered back-projection (FBP), two-dimensional-ordered subsets expectation maximization (OSEM) and maximum a posteriori (MAP) NEMA NU 4-optimized reconstructions for therapy assessment. Varying reconstruction settings were used to determine the parameters for optimal image quality with two NEMA NU 4 phantom acquisitions. Subsequently, data from two experiments in which nude rats bearing subcutaneous tumors had received a dual PI3K/mTOR inhibitor were reconstructed with the NEMA NU 4-optimized parameters. Mann-Whitney tests were used to compare mean standardized uptake value (SUV(mean)) variations among groups. All NEMA NU 4-optimized reconstructions showed the same 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) kinetic patterns and detected a significant difference in SUV(mean) relative to day 0 between controls and treated groups for all time points with comparable p values. In the framework of therapy assessment in rats bearing subcutaneous tumors, all algorithms available on the Inveon system performed equally.

Parametrization of the contribution of mono- and bidentate ligands on the symmetric C[triple bond]O stretching frequency of fac-[Re(CO)(3)](+) complexes.

PubMed

Zobi, Fabio

2009-11-16

A ligand parameter, IR(P)(L), is introduced in order to evaluate the effect that different monodentate and bidentate ligands have on the symmetric C[triple bond]O stretching frequency of octahedral d(6) fac-[Re(CO)(3)L(3)] complexes (L = mono- or bidentate ligand). The parameter is empirically derived by assuming that the electronic effect, or contribution, that any given ligand L will add to the fac-[ReCO(3)](+) core, in terms of the total observed energy of symmetric C[triple bond]O stretching frequency (nu(CO(obs))), is additive. The IR(P)(CO) (i.e., the IR(P) of carbon monoxide) is first defined as one-sixth that of the observed C[triple bond]O frequency (nu(CO(obs))) of [Re(CO)(6)](+). All subsequent IR(P)(L) parameters of fac-[Re(CO)(3)L(3)] complexes are derived from IR(P)(L) = (1)/(3)[nu(CO(obs)) - 3IR(P)(CO)]. The symmetric C[triple bond]O stretching frequency was selected for analysis by assuming that it alone describes the "average electronic environment" in the IR spectra of the complexes. The IR(P)(L) values for over 150 ligands are listed, and the validity of the model is tested against other octahedral d(6) fac-[M(CO)(3)L(3)] complexes (M = Mn, (99)Tc, and Ru) and cis-[Re(CO)(2)L(4)](+) species and by calculations at the density functional level of theory. The predicted symmetric C[triple bond]O stretching frequency (nu(CO(cal))) is given by nu(CO(cal)) = S(R)[ sum IR(P)(L)] + I(R), where S(R) and I(R) are constants that depend upon the metal, its oxidation state, and the number of CO ligands in its primary coordination sphere. A linear relationship between IR(P) values and the well-established ligand electrochemical parameter E(L) is found. From a purely thermodynamic point of view, it is suggested that ligands with high IR(P)(L) values should weaken the M-CO bond to a greater extent than ligands with low IR(P)(L) values. The significance of the results and the limitations of the model are discussed.

Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair.

PubMed

Sunada, Shigeaki; Kanai, Hideki; Lee, Younghyun; Yasuda, Takeshi; Hirakawa, Hirokazu; Liu, Cuihua; Fujimori, Akira; Uesaka, Mitsuru; Okayasu, Ryuichi

2016-09-01

High-linear energy transfer (LET) heavy ions have been increasingly employed as a useful alternative to conventional photon radiotherapy. As recent studies suggested that high LET radiation mainly affects the nonhomologous end-joining (NHEJ) pathway of DNA double strand break (DSB) repair, we further investigated this concept by evaluating the combined effect of an NHEJ inhibitor (NU7441) at a non-toxic concentration and carbon ions. NU7441-treated non-small cell lung cancer (NSCLC) A549 and H1299 cells were irradiated with X-rays and carbon ions (290 MeV/n, 50 keV/μm). Cell survival was measured by clonogenic assay. DNA DSB repair, cell cycle distribution, DNA fragmentation and cellular senescence induction were studied using a flow cytometer. Senescence-associated protein p21 was detected by western blotting. In the present study, 0.3 μM of NU7441, nontoxic to both normal and tumor cells, caused a significant radio-sensitization in tumor cells exposed to X-rays and carbon ions. This concentration did not seem to cause inhibition of DNA DSB repair but induced a significant G2/M arrest, which was particularly emphasized in p53-null H1299 cells treated with NU7441 and carbon ions. In addition, the combined treatment induced more DNA fragmentation and a higher degree of senescence in H1299 cells than in A549 cells, indicating that DNA-PK inhibitor contributes to various modes of cell death in a p53-dependent manner. In summary, NSCLC cells irradiated with carbon ions were radio-sensitized by a low concentration of DNA-PK inhibitor NU7441 through a strong G2/M cell cycle arrest. Our findings may contribute to further effective radiotherapy using heavy ions. © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Preparation, Spectroscopic Characterization, and Frontier MO Study of the Heteronuclear Luminescent [Pt(2)Au(2)(dmb)(2)(PPh(3))(4)](PF(6))(2) Cluster (dmb = 1,8-Diisocyano-p-menthane). A Cluster with a Formal Au(0)-Au(0) Bond Encapsulated inside a "Pt(2)(dmb)(2)(2+) " Fragment.

PubMed

Zhang, Tianle; Drouin, Marc; Harvey, Pierre D.

1999-11-01

The title compound is prepared from the direct reaction of Pt(2)(dba)(3) (dba = dibenzylideneacetone) and [Au(PPh(3))(2)](PF(6)) in the presence of 1,8-diisocyano-p-methane (dmb), with Pt(2)(dmb)(2)Cl(2), [Pt(4)(dmb)(4)(PPh(3))(2)](PF(6))(2), and (PPh(3))AuCl being formed as parallel products. X-ray crystallography reveals the presence of a quasi-linear PPh(3)Au-AuPPh(3) fragment encapsulated inside a "Pt(2)(dmb)(2)(2+)" ring which is axially coordinated with two PPh(3) ligands. The d(AuAu) is 2.5977(6) Å and is indicative of a strong Au-Au single bond. The IR nu(CN) data reveal that the Pt oxidation state is I, which places the Au oxidation state at 0. The PtAu distances are 2.8422(5) and 2.8082(5) Å. The Raman-active nu(Au(2)), nu(PtAu) (b(2g) + a(g)), nu(PtP), nu(AuP), and nu(PtC) are found at 121.2, approximately 100, 85.5, 162.1, 183.1, and 457.2, and 440.9 cm(-)(1), respectively. The PtAu (0.67 mdyn Å(-)(1)) and Au(2) (1.21 mdyn Å(-)(1)) force constants (F) confirm the presence of medium PtAu and strong Au(2) bonding interactions. The absorption spectra are characterized by strong bands at lambda(max) (epsilon, M(-1) cm(-1)) at 316 (32 300), 366 (37 800), and 418 nm (21 500) and lower intensity features at 516 (2860) and 655 nm (834). The cluster is luminescent at low temperatures (solid and frozen glasses), and in the solid state at room temperature, and exhibits an emission band at approximately 875 nm, and an emission lifetime, tau(e), of 4.4 +/- 0.4 ns (solvent = butyronitrile, T = 77 K).

Metamorphic P-T paths and Precambrian crustal growth in East Antarctica

NASA Technical Reports Server (NTRS)

Harley, S. L.

1988-01-01

The metamorphic constraints on crustal thicknesses in Archean and post-Archean terranes are summarized along with possible implications for tectonic processes. It is important to recognize that P-T estimates represent perturbed conditions and should not be used to estimate steady state geothermal gradients or crustal thicknesses. The example is cited of the Dora Maira complex in the French Alps, where crustal rocks record conditions of 35 kbar and 800 C, implying their subduction to depths of 100 km or more, followed by subsequent uplift to the surface. Therefore such P-T estimates tell more about processes than crustal thicknesses. More importantly, according to the author, are determinations of P-T paths, particularly coupled with age measurements, because these may provide constraints on how and when perturbed conditions relax back to steady state conditions. P-T paths are illustrated that should be expected from specific tectonic processes, including Tibetan style collision, with and without subsequent extension, rifting of thin or thickened crust, and magmatic accretion. Growth of new crust, associated with magmatic accretion, for example, could possibly be monitored with these P-T paths.

A modification of the Regional Nutrient Management model (ReNuMa) to identify long-term changes in riverine nitrogen sources

NASA Astrophysics Data System (ADS)

Hu, Minpeng; Liu, Yanmei; Wang, Jiahui; Dahlgren, Randy A.; Chen, Dingjiang

2018-06-01

Source apportionment is critical for guiding development of efficient watershed nitrogen (N) pollution control measures. The ReNuMa (Regional Nutrient Management) model, a semi-empirical, semi-process-oriented model with modest data requirements, has been widely used for riverine N source apportionment. However, the ReNuMa model contains limitations for addressing long-term N dynamics by ignoring temporal changes in atmospheric N deposition rates and N-leaching lag effects. This work modified the ReNuMa model by revising the source code to allow yearly changes in atmospheric N deposition and incorporation of N-leaching lag effects into N transport processes. The appropriate N-leaching lag time was determined from cross-correlation analysis between annual watershed individual N source inputs and riverine N export. Accuracy of the modified ReNuMa model was demonstrated through analysis of a 31-year water quality record (1980-2010) from the Yongan watershed in eastern China. The revisions considerably improved the accuracy (Nash-Sutcliff coefficient increased by ∼0.2) of the modified ReNuMa model for predicting riverine N loads. The modified model explicitly identified annual and seasonal changes in contributions of various N sources (i.e., point vs. nonpoint source, surface runoff vs. groundwater) to riverine N loads as well as the fate of watershed anthropogenic N inputs. Model results were consistent with previously modeled or observed lag time length as well as changes in riverine chloride and nitrate concentrations during the low-flow regime and available N levels in agricultural soils of this watershed. The modified ReNuMa model is applicable for addressing long-term changes in riverine N sources, providing decision-makers with critical information for guiding watershed N pollution control strategies.

Role of a Modulator in the Synthesis of Phase-Pure NU-1000.

PubMed

Webber, Thomas E; Liu, Wei-Guang; Desai, Sai Puneet; Lu, Connie C; Truhlar, Donald G; Penn, R Lee

2017-11-15

NU-1000 is a robust, mesoporous metal-organic framework (MOF) with hexazirconium nodes ([Zr 6 O 16 H 16 ] 8+ , referred to as oxo-Zr 6 nodes) that can be synthesized by combining a solution of ZrOCl 2 ·8H 2 O and a benzoic acid modulator in N,N-dimethylformamide with a solution of linker (1,3,6,8-tetrakis(p-benzoic acid)pyrene, referred to as H 4 TBAPy) and by aging at an elevated temperature. Typically, the resulting crystals are primarily composed of NU-1000 domains that crystallize with a more dense phase that shares structural similarity with NU-901, which is an MOF composed of the same linker molecules and nodes. Density differences between the two polymorphs arise from the differences in the node orientation: in NU-1000, the oxo-Zr 6 nodes rotate 120° from node to node, whereas in NU-901, all nodes are aligned in parallel. Considering this structural difference leads to the hypothesis that changing the modulator from benzoic acid to a larger and more rigid biphenyl-4-carboxylic acid might lead to a stronger steric interaction between the modulator coordinating on the oxo-Zr 6 node and misaligned nodes or linkers in the large pore and inhibit the growth of the more dense NU-901-like material, resulting in phase-pure NU-1000. Side-by-side reactions comparing the products of synthesis using benzoic acid or biphenyl-4-carboxylic acid as a modulator produce structurally heterogeneous crystals and phase-pure NU-1000 crystals. It can be concluded that the larger and more rigid biphenyl-4-carboxylate inhibits the incorporation of nodes with an alignment parallel to the neighboring nodes already residing in the crystal.

Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain.

PubMed

Zhao, Ling-Jun; Loewenstein, Paul M; Green, Maurice

2016-12-01

The adenovirus E1A 243R oncoprotein targets TRRAP, a scaffold protein that assembles histone acetyltransferase (HAT) complexes, such as the NuA4/Tip60 complex which mediates transcriptional activity of the proto-oncogene MYC and helps determine the cancer cell phenotype. How E1A transforms cells through TRRAP remains obscure. We performed proteomic analysis with the N-terminal transcriptional repression domain of E1A 243R (E1A 1-80) and showed that E1A 1-80 interacts with TRRAP, p400, and three other members of the NuA4 complex - DMAP1, RUVBL1 and RUVBL2 - not previously shown to associate with E1A 243R. E1A 1-80 interacts with these NuA4 components and MYC through the E1A TRRAP-targeting domain. E1A 243R association with the NuA4 complex was demonstrated by co-immunoprecipitation and analysis with DMAP1, Tip60, and MYC. Significantly, E1A 243R promotes association of MYC/MAX with the NuA4/Tip60 complex, implicating the importance of the MYC/NuA4 pathway in cellular transformation by both MYC and E1A. Copyright © 2016 Elsevier Inc. All rights reserved.

Disinfection efficacy of contact lens care solutions against ocular pathogens.

PubMed

Miller, M J; Callahan, D E; McGrath, D; Manchester, R; Norton, S E

2001-01-01

Three commercially available products labeled as multi-purpose contact lens solutions, one multi-purpose disinfecting solution, and a hydrogen peroxide system were evaluated for antimicrobial activity according to the current International Organization for Standardization (ISO) and the U.S. Food and Drug Administration (FDA) stand-alone procedure for disinfecting products. One multi-purpose solution was selected to assess its antimicrobial activity against two human corneal isolates of Pseudomonas aeruginosa. Products were challenged with bacteria and fungi, and following a specified period, aliquots of inoculated test solution were neutralized and plated on validated recovery media. After incubation the number of viable microorganisms was enumerated and mean log reductions determined. ReNu MultiPlus (Bausch & Lomb, Rochester, NY), AOSEPT (CIBA Vision Corporation, Duluth, GA), and Opti-Free Express with Aldox (Alcon Laboratories, Ft. Worth, TX) were the only lens care products that met the stand-alone criteria for all required microorganisms within their minimum recommended disinfection time. Of these, ReNu MultiPlus provided the greatest overall antimicrobial activity. ReNu MultiPlus demonstrated a significantly higher mean log reduction of Staphylococcus aureus and Serratia marcescens than Opti-Free Express. ReNu MultiPlus also gave a higher mean log reduction of S. aureus and S. marcescens than AOSEPT, and a higher mean log reduction of Candida albicans and Fusarium solani than AOSEPT, Complete Comfort Plus (Allergan, Irivine, CA), and Solo-Care (CIBA Vision Corp.) (at 4 hours). Both Complete Comfort Plus and Solo-Care (at 4 hours) met the primary acceptance criteria for bacteria; however, neither product possessed enough antimicrobial activity to meet the minimum criteria for yeast or mold. ReNu Multiplus was effective against corneal isolates of P. aeruginosa. ReNu MultiPlus, AOSEPT, and Opti-Free Express met the requirements of the stand-alone primary criteria for disinfecting solutions. ReNu MultiPlus demonstrated the greatest overall disinfection efficacy, as well as excellent activity against clinical strains of P. aeruginosa.

Use of acoustic wave travel-time measurements to probe the near-surface layers of the Sun

NASA Technical Reports Server (NTRS)

Jefferies, S. M.; Osaki, Y.; Shibahashi, H.; Duvall, T. L., Jr.; Harvey, J. W.; Pomerantz, M. A.

1994-01-01

The variation of solar p-mode travel times with cyclic frequency nu is shown to provide information on both the radial variation of the acoustic potential and the depth of the effective source of the oscillations. Observed travel-time data for waves with frequency lower than the acoustic cutoff frequency for the solar atmosphere (approximately equals 5.5 mHz) are inverted to yield the local acoustic cutoff frequency nu(sub c) as a function of depth in the outer convection zone and lower atmosphere of the Sun. The data for waves with nu greater than 5.5 mHz are used to show that the source of the p-mode oscillations lies approximately 100 km beneath the base of the photosphere. This depth is deeper than that determined using a standard mixing-length calculation.

Inelastic collision processes in ozone and their relation to atmospheric pressure broadening

NASA Technical Reports Server (NTRS)

Steinfeld, J. I.; Flannery, C.; Klaassen, J.; Mizugai, Y.; Spencer, M.

1990-01-01

The research task employs infrared double-resonance to determine rotational energy transfer rates and pathways, in both the ground and vibrationally excited states of ozone. The resulting data base will then be employed to test inelastic scattering theories and to assess intermolecular potential models, both of which are necessary for the systematization and prediction of infrared pressure-broadening coefficients, which are in turn required by atmospheric ozone monitoring techniques based on infrared remote sensing. In addition, observation of excited-state absorption transitions will permit us to improve the determination of the 2 nu(sub 3), nu(sub 1) + nu(sub 2), and 2 nu(sub 1) rotational constants and to derive band strengths for hot-band transitions involving these levels.

Neutral-strange-particle production in 200-GeV/ c p /. pi. sup + / K sup + interactions on Au, Ag, and Mg

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brick, D.H.; Widgoff, M.; Beilliere, P.

1992-02-01

We have used the Fermilab 30-in. bubble-chamber--hybrid spectrometer to study neutral-strange-particle production in the interactions of 200-GeV/{ital c} protons and {pi}{sup +} and {ital K}{sup +} mesons with nuclei of gold, silver, and magnesium. Average multiplicities and inclusive cross sections for {ital K}{sup 0} and {Lambda} are measured, and a power law is found to give a good description of their {ital A} dependence. The exponent characterizing the {ital A} dependence is consistent with being the same for {ital K}{sup 0} and {Lambda} production, and also the same for proton and {pi}{sup +} beams. Average {ital K}{sup 0} and {Lambda}more » multiplicities, as well as their ratio, have been measured as functions of the numbers of projectile collisions {nu}{sub {ital p}} and secondary collisions {nu}{sub {ital s}} in the nucleus, and indicate that rescattering contributes significantly to enhancement of {Lambda} production but not to {ital K}{sup 0} production. The properties of events with multiple {ital K}{sup 0}'s or {Lambda}'s also corroborate this conclusion. {ital K}{sup 0} rapidities are in the central region and decrease gently with increasing {nu}{sub {ital p}}, while {Lambda} rapidities are in the target-fragmentation region and are independent of {nu}{sub {ital p}}. {ital K}{sup 0} and {Lambda} multiplicities increase with the rapidity loss of the projectile, but their rapidities do not.« less

KSC-2012-3025

NASA Image and Video Library

2012-05-22

VANDENBERG AFB, Calif. – Technicians install one half of the payload fairing over the NuSTAR spacecraft as they continue to process the spacecraft and its Pegasus rocket for launch. The second half of the fairing stands ready for installation. NuSTAR stands for Nuclear Spectroscopic Telescope Array. Photo credit: NASA/Randy Beaudoin

Double beta decays of {sup 106}Cd

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suhonen, Jouni

2011-12-16

The two-neutrino (2{nu}2{beta}) and neutrinoless (0{nu}2{beta}) double beta decays of {sup 106}Cd are studied for the transitions to the ground state 0{sub gs}{sup +} and 0{sup +} and 2{sup +} excited states in {sup 106}Pd by using realistic many-body wave functions calculated in the framework of the quasiparticle random-phase approximation. Effective, G-matrix-derived nuclear forces are used in realistic single-particle model spaces. All the possible channels, {beta}{sup +}{beta}{sup +}, {beta}{sup +}EC, and ECEC, are discussed for both the 2{nu}2{beta} and 0{nu}2{beta} decays. The associated half-lives are computed and particular attention is devoted to the study of the detectability of the resonantmore » neutrinoless double electron capture (R0{nu}ECEC) process in {sup 106}Cd. The calculations of the present article constitute the thus far most complete and up-to-date investigation of the double-beta-decay properties of {sup 106}Cd.« less

A new method of detecting changes in corneal health in response to toxic insults.

PubMed

Khan, Mohammad Faisal Jamal; Nag, Tapas C; Igathinathane, C; Osuagwu, Uchechukwu L; Rubini, Michele

2015-11-01

The size and arrangement of stromal collagen fibrils (CFs) influence the optical properties of the cornea and hence its function. The spatial arrangement of the collagen is still questionable in relation to the diameter of collagen fibril. In the present study, we introduce a new parameter, edge-fibrillar distance (EFD) to measure how two collagen fibrils are spaced with respect to their closest edges and their spatial distribution through normalized standard deviation of EFD (NSDEFD) accessed through the application of two commercially available multipurpose solutions (MPS): ReNu and Hippia. The corneal buttons were soaked separately in ReNu and Hippia MPS for five hours, fixed overnight in 2.5% glutaraldehyde containing cuprolinic blue and processed for transmission electron microscopy. The electron micrographs were processed using ImageJ user-coded plugin. Statistical analysis was performed to compare the image processed equivalent diameter (ED), inter-fibrillar distance (IFD), and EFD of the CFs of treated versus normal corneas. The ReNu-soaked cornea resulted in partly degenerated epithelium with loose hemidesmosomes and Bowman's collagen. In contrast, the epithelium of the cornea soaked in Hippia was degenerated or lost but showed closely packed Bowman's collagen. Soaking the corneas in both MPS caused a statistically significant decrease in the anterior collagen fibril, ED and a significant change in IFD, and EFD than those of the untreated corneas (p<0.05, for all comparisons). The introduction of EFD measurement in the study directly provided a sense of gap between periphery of the collagen bundles, their spatial distribution; and in combination with ED, they showed how the corneal collagen bundles are spaced in relation to their diameters. The spatial distribution parameter NSDEFD indicated that ReNu treated cornea fibrils were uniformly distributed spatially, followed by normal and Hippia. The EFD measurement with relatively lower standard deviation and NSDEFD, a characteristic of uniform CFs distribution, can be an additional parameter used in evaluating collagen organization and accessing the effects of various treatments on corneal health and transparency. Copyright © 2015 Elsevier Ltd. All rights reserved.

Non-Invasive Detection of Lactate as a Biomarker of Response using Spectral Selective Multiple Quantum Editing Sequence (SS-SelMQC)

DTIC Science & Technology

2013-11-01

breast tumor cell lines injected into mammary fat pad (m.f.p) in nude mice. Tumor cells (5x106 cells) were injected into the m.f.p and tumor...the inguinal mammary fat pad (MFP) of anaesthetized mice. 4-6-week-old female athymic nu/nu mice (Animal Production Area of the NCI- Frederick...6 the subcutaneous fat in the hips of animals that were about to receive these tumors. Mice were monitored twice weekly for tumor growth. Tumor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaing, K.C.

The poloidal flow damping rate in the vicinity of the magnetic axis in tokamaks is calculated using the time-dependent plasma viscosity. It is found that the damping rate is of the order of {nu}{sub ii}/f{sub t}{sup 2}, where {nu}{sub ii} is the ion-ion collision frequency, and f{sub t} is the fraction of the trapped potatoes. The corresponding neoclassical polarization or inertia enhancement factor is [1+({sigma}{sub p}q{sup 2}/f{sub t})], where {sigma}{sub p} is a numerical number of the order of unity, and q is the safety factor.

Characterization of a bioflocculant produced by the marine myxobacterium Nannocystis sp. NU-2.

PubMed

Zhang, J; Liu, Z; Wang, S; Jiang, P

2002-08-01

The marine myxobacterium strain NU-2, which can grow on high concentrations (up to 7%) of NaCl, was isolated from a salt soil sample collected from the coast of the Huanghai Sea, China. Morphological properties and 16S rDNA sequence analysis indicated that the isolate is a novel species related to the genus Nannocystis. Nannocystis sp. NU-2 produced a new kind of flocculating substance in a starch medium with a yield of 14.8 g l(-1). The NU-2 flocculant was composed of 40.3% proteins and 56.5% polysaccharides, of which glucose, mannose and glucuronic acid were the principal constituents in the relative proportions of 5:4:1. The flocculation activity of the NU-2 flocculant depends strongly on cations such as Fe(3+) and Al(3+). When a 30 mg l(-1) FeCl(3) solution is present in kaolin clay suspension, 30 mg l(-1)of the flocculant produced a high flocculating activity value of 90%, which remained unchanged over an extensive pH range (pH 2.0-13.0). The flocculant was tested for its ability to bleach dyeing liquors, and the bleaching activities were 98.2% for acid red in 100 mg l(-1)of the flocculant and 99.0% for direct emerald blue in 50 mg l(-1)of the flocculant under test conditions. Use of the flocculant to bleach basic pink and cation emerald blue liquors was not effective.

The Nucleosome Remodeling and Deacetylase (NuRD) Complex in Development and Disease

PubMed Central

Basta, Jeannine; Rauchman, Michael

2014-01-01

The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis and accelerated ageing. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer. PMID:24880148

Roles for the Histone Modifying and Exchange Complex NuA4 in Cell Cycle Progression in Drosophila melanogaster.

PubMed

Flegel, Kerry; Grushko, Olga; Bolin, Kelsey; Griggs, Ellen; Buttitta, Laura

2016-07-01

Robust and synchronous repression of E2F-dependent gene expression is critical to the proper timing of cell cycle exit when cells transition to a postmitotic state. Previously NuA4 was suggested to act as a barrier to proliferation in Drosophila by repressing E2F-dependent gene expression. Here we show that NuA4 activity is required for proper cell cycle exit and the repression of cell cycle genes during the transition to a postmitotic state in vivo However, the delay of cell cycle exit caused by compromising NuA4 is not due to additional proliferation or effects on E2F activity. Instead NuA4 inhibition results in slowed cell cycle progression through late S and G2 phases due to aberrant activation of an intrinsic p53-independent DNA damage response. A reduction in NuA4 function ultimately produces a paradoxical cell cycle gene expression program, where certain cell cycle genes become derepressed in cells that are delayed during the G2 phase of the final cell cycle. Bypassing the G2 delay when NuA4 is inhibited leads to abnormal mitoses and results in severe tissue defects. NuA4 physically and genetically interacts with components of the E2F complex termed D: rosophila, R: bf, E: 2F A: nd M: yb/ M: ulti-vulva class B: (DREAM/MMB), and modulates a DREAM/MMB-dependent ectopic neuron phenotype in the posterior wing margin. However, this effect is also likely due to the cell cycle delay, as simply reducing Cdk1 is sufficient to generate a similar phenotype. Our work reveals that the major requirement for NuA4 in the cell cycle in vivo is to suppress an endogenous DNA damage response, which is required to coordinate proper S and G2 cell cycle progression with differentiation and cell cycle gene expression. Copyright © 2016 by the Genetics Society of America.

Roles for the Histone Modifying and Exchange Complex NuA4 in Cell Cycle Progression in Drosophila melanogaster

PubMed Central

Flegel, Kerry; Grushko, Olga; Bolin, Kelsey; Griggs, Ellen; Buttitta, Laura

2016-01-01

Robust and synchronous repression of E2F-dependent gene expression is critical to the proper timing of cell cycle exit when cells transition to a postmitotic state. Previously NuA4 was suggested to act as a barrier to proliferation in Drosophila by repressing E2F-dependent gene expression. Here we show that NuA4 activity is required for proper cell cycle exit and the repression of cell cycle genes during the transition to a postmitotic state in vivo. However, the delay of cell cycle exit caused by compromising NuA4 is not due to additional proliferation or effects on E2F activity. Instead NuA4 inhibition results in slowed cell cycle progression through late S and G2 phases due to aberrant activation of an intrinsic p53-independent DNA damage response. A reduction in NuA4 function ultimately produces a paradoxical cell cycle gene expression program, where certain cell cycle genes become derepressed in cells that are delayed during the G2 phase of the final cell cycle. Bypassing the G2 delay when NuA4 is inhibited leads to abnormal mitoses and results in severe tissue defects. NuA4 physically and genetically interacts with components of the E2F complex termed Drosophila, Rbf, E2F and Myb/Multi-vulva class B (DREAM/MMB), and modulates a DREAM/MMB-dependent ectopic neuron phenotype in the posterior wing margin. However, this effect is also likely due to the cell cycle delay, as simply reducing Cdk1 is sufficient to generate a similar phenotype. Our work reveals that the major requirement for NuA4 in the cell cycle in vivo is to suppress an endogenous DNA damage response, which is required to coordinate proper S and G2 cell cycle progression with differentiation and cell cycle gene expression. PMID:27184390

Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813.

PubMed

Chang, Susan; Zhang, Peixin; Cairncross, J Gregory; Gilbert, Mark R; Bahary, Jean-Paul; Dolinskas, Carol A; Chakravarti, Arnab; Aldape, Kenneth D; Bell, Erica H; Schiff, David; Jaeckle, Kurt; Brown, Paul D; Barger, Geoffrey R; Werner-Wasik, Maria; Shih, Helen; Brachman, David; Penas-Prado, Marta; Robins, H Ian; Belanger, Karl; Schultz, Christopher; Hunter, Grant; Mehta, Minesh

2017-02-01

The primary objective of this study was to compare the overall survival (OS) of patients with anaplastic astrocytoma (AA) treated with radiotherapy (RT) and either temozolomide (TMZ) or a nitrosourea (NU). Secondary endpoints were time to tumor progression (TTP), toxicity, and the effect of IDH1 mutation status on clinical outcome. Eligible patients with centrally reviewed, histologically confirmed, newly diagnosed AA were randomized to receive either RT+TMZ (n = 97) or RT+NU (n = 99). The study closed early because the target accrual rate was not met. Median follow-up time for patients still alive was 10.1 years (1.9-12.6 y); 66% of the patients died. Median survival time was 3.9 years in the RT/TMZ arm (95% CI, 3.0-7.0) and 3.8 years in the RT/NU arm (95% CI, 2.2-7.0), corresponding to a hazard ratio (HR) of 0.94 (P = .36; 95% CI, 0.67-1.32). The differences in progression-free survival (PFS) and TTP between the 2 arms were not statistically significant. Patients in the RT+NU arm experienced more grade ≥3 toxicity (75.8% vs 47.9%, P < .001), mainly related to myelosuppression. Of the 196 patients, 111 were tested for IDH1-R132H status (60 RT+TMZ and 51 RT+NU). Fifty-four patients were IDH negative and 49 were IDH positive with a better OS in IDH-positive patients (median survival time 7.9 vs 2.8 y; P = .004, HR = 0.50; 95% CI, 0.31-0.81). RT+TMZ did not appear to significantly improve OS or TTP for AA compared with RT+ NU. RT+TMZ was better tolerated. IDH1-R132H mutation was associated with longer survival. © The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Resonance Raman spectra of an O2-binding H-NOX domain reveal heme relaxation upon mutation.

PubMed

Tran, Rosalie; Boon, Elizabeth M; Marletta, Michael A; Mathies, Richard A

2009-09-15

Resonance Raman spectra were measured for the wild type Heme-Nitric oxide/OXygen binding domain from Thermoanaerobacter tengcongensis (Tt H-NOX WT) and three other Tt H-NOX proteins containing mutations at key conserved residues to determine the heme conformation in solution. The most dramatic changes in heme conformation occurred in the O2-bound forms, and the single Tt H-NOX P115A mutation was sufficient to generate a significant relaxation of the chromophore. Clear evidence of heme relaxation in the Tt H-NOX I5L, P115A, and I5L/P115A mutants in solution is demonstrated by the observation of reduced resonance Raman intensities for several out-of-plane low frequency modes (e.g., gamma11, gamma12, gamma13, and gamma15) in the 400-750 cm(-1) region known to be sensitive to ruffling and saddling deformations, as well as increased vibrational frequencies for the core heme skeletal stretching modes, nu3, nu2, and nu10. In addition, all three mutants exhibited some degree of heme conformational heterogeneity based on several broad skeletal markers (e.g., nu10) in the high frequency region. These results are comparable to those observed by Olea et al. for Tt H-NOX P115A in crystal form, where four different heme structures were determined from a single unit cell. On the basis of the resonance Raman spectra, it is clear that the actual heme conformation for Tt H-NOX P115A in solution is considerably more relaxed than that of the WT protein, with increased flexibility within the protein pocket, allowing for rapid sampling of alternate conformations.

Depression and reduced heart rate variability after cardiac surgery: the mediating role of emotion regulation.

PubMed

Patron, Elisabetta; Messerotti Benvenuti, Simone; Favretto, Giuseppe; Gasparotto, Renata; Palomba, Daniela

2014-02-01

Heart rate variability (HRV), as an index of autonomic nervous system (ANS) functioning, is reduced by depression after cardiac surgery, but the underlying mechanisms of this relationship are poorly understood. Poor emotion regulation as a core symptom of depression has also been associated with altered ANS functioning. The present study aimed to examine whether emotion dysregulation could be a mediator of the depression-reduced HRV relationship observed after cardiac surgery. Self-reported emotion regulation and four-minute HRV were measured in 25 depressed and 43 nondepressed patients after cardiac surgery. Mediation analysis was conducted to evaluate emotion regulation as a mediator of the depression-reduced HRV relationship. Compared to nondepressed patients, those with depression showed lower standard deviation of normal-to-normal (NN) intervals (p<.05), root mean square successive difference of NN intervals (p<.004), and number of interval differences of successive NN intervals greater than 50ms (NN50) (p<.05). Increased low frequency (LF) in normalized units (n.u.) and reduced high frequency (HF) n.u. were also found in depressed compared to nondepressed patients (p's<.01). Mediation analysis revealed that suppression of emotion-expressive behavior partially mediated the effect of depression on LF n.u. and HF n.u. Results confirmed previous findings showing that depression is associated with reduced HRV, especially a reduced vagal tone and a sympathovagal imbalance, after cardiac surgery. This study also provides preliminary evidence that increased trait levels of suppression of emotion-expressive behavior may mediate the depression-related sympathovagal imbalance after cardiac surgery. Copyright © 2013 Elsevier B.V. All rights reserved.

KSC-2012-1259

NASA Image and Video Library

2012-02-03

VANDENBERG AIR FORCE BASE, Calif. – In processing facility 1555 at Vandenberg Air Force Base in California, spacecraft technicians move a Pegasus fairing separation ring toward the workstand for NASA's Nuclear Spectroscopic Telescope Array (NuSTAR). A Pegasus XL rocket is being prepared to launch NuSTAR into space in March. Once processing of the rocket and spacecraft are completed at Vandenberg, they will be flown on the Orbital Sciences’ L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean’s Kwajalein Atoll for launch. NuSTAR, a high-energy x-ray telescope, will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

Comparative effect of lens care solutions on blink rate, ocular discomfort and visual performance.

PubMed

Yang, Shun-nan; Tai, Yu-chi; Sheedy, James E; Kinoshita, Beth; Lampa, Matthew; Kern, Jami R

2012-09-01

To help maintain clear vision and ocular surface health, eye blinks occur to distribute natural tears over the ocular surface, especially the corneal surface. Contact lens wearers may suffer from poor vision and dry eye symptoms due to difficulty in lens surface wetting and reduced tear production. Sustained viewing of a computer screen reduces eye blinks and exacerbates such difficulties. The present study evaluated the wetting effect of lens care solutions (LCSs) on blink rate, dry eye symptoms, and vision performance. Sixty-five adult habitual soft contact lens wearers were recruited to adapt to different LCSs (Opti-free, ReNu, and ClearCare) in a cross-over design. Blink rate in pictorial viewing and reading (measured with an eyetracker), dry eye symptoms (measured with the Ocular Surface Disease Index questionnaire), and visual discrimination (identifying tumbling E) immediately before and after eye blinks were measured after 2 weeks of adaption to LCS. Repeated measures anova and mixed model ancova were conducted to evaluate effects of LCS on blink rate, symptom score, and discrimination accuracy. Opti-Free resulted in lower dry eye symptoms (p = 0.018) than ClearCare, and lower spontaneous blink rate (measured in picture viewing) than ClearCare (p = 0.014) and ReNu (p = 0.041). In reading, blink rate was higher for ClearCare compared to ReNu (p = 0.026) and control (p = 0.024). Visual discrimination time was longer for the control (daily disposable lens) than for Opti-Free (p = 0.007), ReNu (p = 0.009), and ClearCare (0.013) immediately before the blink. LCSs differently affected blink rate, subjective dry eye symptoms, and visual discrimination speed. Those with wetting agents led to significantly fewer eye blinks while affording better ocular comfort for contact lens wearers, compared to that without. LCSs with wetting agents also resulted in better visual performance compared to wearing daily disposable contact lenses. These presumably are because of improved tear film quality. © 2012 The College of Optometrists.

Neutrino Production of Opposite Sign Dimuons at the Fnal TEVATRON*.

NASA Astrophysics Data System (ADS)

Foudas, Constantinos

Neutrino-Nucleon (nu-N) interactions with two opposite sign muons (mu ^-mu^+) in the final state have been studied using the CCFR Detector and the Fermilab Quad Triplet Beam (FNAL-E744). In a sample of 670,000 nu-N and 124,000 |nu -N charged-current interactions, a total of 1522 nu-induced and 275 | nu-induced mu^-mu ^+ events have been observed, with 30 GeV < E_{nu} < 600 GeV and P_ {mu} > 9 GeV/c for both muons. The opposite sign dimuon data are consistent with the slow rescaling hypothesis of charm production in nu-N scattering, and within this formalism yield, a value of the charm quark mass parameter m_ c = 1.31_sp{ -0.48}{+0.64} GeV/c^2 . Using the opposite sign dimuon data after background subtraction we measured the strange quark content of the nucleon eta_ s = 0.057 _sp{-0.008}{+0.012} and the Kobayashi-Maskawa (KM) matrix element | V_{cd}| = 0.220_sp{ -0.018}{+0.015}. The nucleon momentum fraction carried by the strange quarks relative to non -strange quarks in the quark sea is kappa = 0.44_sp{-0.07}{+0.11 } which is approximately half that expected for an SU(3) flavor symmetric quark sea, and the strange quark momentum distribution is consistent with that of | u and | d. ftn*Research supported by the National Science Foundation. Submitted in partial fulfillment of the requirement for the degree of Doctor of Philosophy in the Graduate School of Arts and Sciences, Columbia University.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaltonen, T.; /Helsinki Inst. of Phys.; Abulencia, A.

We describe a measurement of the W boson mass m{sub W} using 200 pb{sup -1} of {radical}s = 1.96 TeV p{bar p} collision data taken with the CDF II detector. With a sample of 63,964 W {yields} e{nu} candidates and 51,128 W {yields} {mu}{nu} candidates, we measure m{sub W} = [80.413 {+-} 0.034(stat.) {+-} 0.034 (sys.) = 80.413 {+-} 0.048] GeV/c{sup 2}. This is the single most precise m{sub W} measurement to date. When combined with other measured electroweak parameters, this result further constrains the properties of new unobserved particles coupling to W and Z bosons.

Exact, E = 0, classical and quantum solutions for general power-law oscillators

NASA Technical Reports Server (NTRS)

Nieto, Michael Martin; Daboul, Jamil

1995-01-01

For zero energy, E = 0, we derive exact, classical and quantum solutions for all power-law oscillators with potentials V(r) = -gamma/r(exp nu), gamma greater than 0 and -infinity less than nu less than infinity. When the angular momentum is non-zero, these solutions lead to the classical orbits (p(t) = (cos mu(phi(t) - phi(sub 0)t))(exp 1/mu) with mu = nu/2 - 1 does not equal 0. For nu greater than 2, the orbits are bound and go through the origin. We calculate the periods and precessions of these bound orbits, and graph a number of specific examples. The unbound orbits are also discussed in detail. Quantum mechanically, this system is also exactly solvable. We find that when nu is greater than 2 the solutions are normalizable (bound), as in the classical case. Further, there are normalizable discrete, yet unbound, states. They correspond to unbound classical particles which reach infinity in a finite time. Finally, the number of space dimensions of the system can determine whether or not an E = 0 state is bound. These and other interesting comparisons to the classical system will be discussed.

High-resolution infrared study of vinyl fluoride in the 750-1050 cm(-1) region: rovibrational analysis and resonances involving the nu8, nu10, and nu11 fundamentals.

PubMed

Tasinato, Nicola; Stoppa, Paolo; Charmet, A Pietropolli; Giorgianni, Santi; Gambi, Alberto

2006-12-21

The FTIR spectra of CH2[double bond]CHF have been investigated in the nu(8), nu(10), and nu(11) region between 750 and 1050 cm(-1) at a resolution of about 0.002 cm(-1). The nu(8) vibration of symmetry species A' gives rise to an a/b-type hybrid band, while the nu(10) and nu(11) modes of A' ' symmetry produce c-type absorptions. Due to the proximity of their band origins, the three vibrations perturb each other by Coriolis and high-order anharmonic resonances. In particular, the interactions between the nu(8) and nu(10) modes are very strong and widespread with band origins separated by only 1.37 cm(-1). Besides the expected c-type characteristics, the nu(10) band shows a very intense pseudo a-type component caused by the strong first-order Coriolis resonances with the nu(8) state. Furthermore, the 2nu(9) "dark state" was found to be involved in the interacting band systems. The spectral analysis resulted in the identification of 3144, 3235, and 3577 transitions of the nu(8), nu(10), and nu(11) vibrations, respectively. Almost all the assigned data were simultaneously fitted using the Watson's A-reduction Hamiltonian in the Ir representation and the perturbation operators. The model employed includes nine types of resonances within the tetrad nu(8)/nu(10)/nu(11)/2nu(9) and a set of spectroscopic constants for the nu(8), nu(10), and nu(11) fundamentals as well as parameters for the "dark state" 2nu(9), and fourteen coupling terms have been determined.

Exchange-driven growth.

PubMed

Ben-Naim, E; Krapivsky, P L

2003-09-01

We study a class of growth processes in which clusters evolve via exchange of particles. We show that depending on the rate of exchange there are three possibilities: (I) Growth-clusters grow indefinitely, (II) gelation-all mass is transformed into an infinite gel in a finite time, and (III) instant gelation. In regimes I and II, the cluster size distribution attains a self-similar form. The large size tail of the scaling distribution is Phi(x) approximately exp(-x(2-nu)), where nu is a homogeneity degree of the rate of exchange. At the borderline case nu=2, the distribution exhibits a generic algebraic tail, Phi(x) approximately x(-5). In regime III, the gel nucleates immediately and consumes the entire system. For finite systems, the gelation time vanishes logarithmically, T approximately [lnN](-(nu-2)), in the large system size limit N--> infinity. The theory is applied to coarsening in the infinite range Ising-Kawasaki model and in electrostatically driven granular layers.

KSC-2012-1378

NASA Image and Video Library

2012-02-16

VANDENBERG AIR FORCE BASE, Calif. -- Technicians watch closely as NASA's NuSTAR spacecraft is Under the watchful eyes of technicians, NASA's NuSTAR spacecraft is lifted inside Orbital Sciences' processing facility at Vandenberg Air Force Base, Calif. The spacecraft will be rotated to horizontal for joining with the Pegasus XL rocket. The Orbital Sciences Pegasus will launch NASA's Nuclear Spectroscopic Telescope Array NuSTAR into space. After the rocket and spacecraft are processed at Vandenberg, they will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean’s Kwajalein Atoll for launch. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit science.nasa.gov/missions/nustar/. Photo credit: NASA/Randy Beaudoin, VAFB

Adsorption of a Catalytically Accessible Polyoxometalate in a Mesoporous Channel-type Metal–Organic Framework

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buru, Cassandra T.; Li, Peng; Mehdi, B. Layla

2017-05-22

A Keggin-type polyoxometalate (H3PW12O40) was incorporated into a mesoporous Zr-based MOF (NU-1000) via an impregnation method in aqueous media, resulting in the hybrid material, PW12@NU-1000. The POM@MOF composite was characterized by a suite of physical methods, indicating the retention of crystallinity and high porosity of the parent MOF. The hybrid material was also stable to leaching in aqueous media at varying pH. Finally, the material was tested as a heterogeneous catalyst for the oxidation of 2-chloroethyl ethyl sulfide using hydrogen peroxide as the oxidant. PW12@NU-1000 was shown to have a higher catalytic activity than either of the individual constituents alone.

Collisional Removal of OH (X (sup 2)Pi, nu=7) by O2, N2, CO2, and N2O

NASA Technical Reports Server (NTRS)

Knutsen, Karen; Dyer, Mark J.; Copeland, Richard A.

1996-01-01

Collisional removal rate constants for the OH (X 2PI, nu = 7) radical are measured for the colliders O2, CO2, and N2O, and an upper limit is established for N2. OH(nu = 4) molecules, generated in a microwave discharge flow cell by the reaction of hydrogen atoms with ozone, are excited to v = 7 by the output of a pulsed infrared laser via direct vibrational overtone excitation. The temporal evolution of the P = 7 population is probed as a function of the collider gas partial pressure by a time-delayed pulsed ultraviolet laser. Fluorescence from the B 21 + state is detected in the visible spectral region.

Evaluation of implant osseointegration with different regeneration techniques in the treatment of bone defects around implants: an experimental study in a rabbit model.

PubMed

Guerra, Isabel; Morais Branco, Fernando; Vasconcelos, Mário; Afonso, Américo; Figueiral, Helena; Zita, Raquel

2011-03-01

The aim of this study was to evaluate the osseointegration of implants placed in areas with artificially created bone defects, using three bone regeneration techniques. The experimental model was the rabbit femur (16), where bone defects were created and implants were placed. The peri-implant bone defects were filled with a deproteinized bovine bone mineral, NuOss™ (N), NuOss™ combined with plasma rich in growth factors (PRGF) (N+PRGF), NuOss™ covered by an RCM(6) membrane (N+M), or remained unfilled (control group [C]). After 4 and 8 weeks, the animals were euthanized and bone tissue blocks with the implants and the surrounding bone tissue were removed and processed according to a histological protocol for hard tissues on non-decalcified ground sections. The samples were studied by light and electron scanning microscopy, histometric analysis was performed to assess the percentage of bone in direct contact with the implant surface and a statistical analysis of the results was performed. In the samples analyzed 4 weeks after implantation, the percentage of bone tissue in direct contact with the implant surface for the four groups were 57.66±24.39% (N), 58.62±20.37% (N+PRGF), 70.82±20.34 % (N+M) and 33.07±5.49% (C). In the samples with 8 weeks of implantation time, the percentage of bone in direct contact was 63.35±27.69% (N), 58.42±24.77% (N+PRGF), 78.02±15.13% (N+M) and 40.28±27.32% (C). In terms of the percentage of bone contact, groups N and N+M presented statistically significant differences from group C in the 4-week trial test (P<0.05; ANOVA). For the 8-week results, only group N+M showed statistically significant differences when compared with group C (P<0.05; ANOVA). In conclusion, the NuOss™ granules/RCM(6) membrane combination presented a percentage of bone contact with the implant surface statistically greater than in the other groups. © 2010 John Wiley & Sons A/S.

Quark-hadron duality and parity violating asymmetry of electroweak reactions in the {delta} region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matsui, K.; Sato, T.; Lee, T.-S.H.

2005-08-01

A dynamical model [T. Sato and T.-S. H. Lee, Phys. Rev. C 54, 2660 (1996); 63, 055201 (2001); T. Sato, D. Uno, and T.-S. H. Lee, ibid. 67, 065201 (2003)] of electroweak pion production reactions in the {delta}(1232) region has been extended to include the neutral current contributions for examining the local quark-hadron duality in neutrino-induced reactions and for investigating how the axial N-{delta} form factor can be determined by the parity violating asymmetry of N(e{sup {yields}},e{sup '}) reactions. We first show that the recent data of (e,e{sup '}) structure functions F{sub 1} and F{sub 2}, which exhibit the quark-hadronmore » duality, are in good agreement with our predictions. For possible future experimental tests, we then predict that the structure functions F{sub 1},F{sub 2}, and F{sub 3} for ({nu},e) and ({nu},{nu}{sup '}) processes also show the similar quark-hadron duality. The spin-dependent structure functions g{sub 1} and g{sub 2} of (e,e{sup '}) have also been calculated from our model. It is found that the local quark-hadron duality is not seen in the calculated g{sub 1} and g{sub 2}, while our results for g{sub 1} and some polarization observables associated with the exclusive p(e{sup {yields}},e{sup '}{pi}) and p{sup {yields}}(e{sup {yields}},e{sup '}{pi}) reactions are in reasonably good agreement with the recent data. In the study of parity violating asymmetry A of N(e{sup {yields}},e{sup '}) reactions, the relative importance between the nonresonant mechanisms and the {delta} excitation is investigated by taking into account the unitarity condition. Predictions are made for using the data of A to test the axial N-{delta} form factors determined previously in the studies of N({nu}{sub {mu}},{mu}{sup -}{pi}) reactions. The predicted asymmetry A are also compared with the parton model predictions for future experimental investigations of quark-hadron duality.« less

High-Resolution Infrared Spectra of Spiropentane, C5H8

DOE Office of Scientific and Technical Information (OSTI.GOV)

Price, Joseph E.; Coulterpark, K. A.; Masiello, Tony

2011-09-01

Infrared spectra of spiropentane (C{sub 5}H{sub 8}) have been recorded at a resolution (0.002 cm{sup -1}) sufficient to resolve for the first time individual rovibrational lines. This initial report presents the ground state constants for this molecule determined from the detailed analysis of the {nu}16 (b2) parallel band at 993 cm{sup -1}. In addition, the determination included more than 2000 ground state combination-differences deduced from partial analyses of four other infrared-allowed bands, the {nu}24(e) perpendicular band at 780 cm{sup -1} and three (b2) parallel bands at 1540 cm{sup -1} ({nu}14), 1568 cm{sup -1} ({nu}5+{nu}16), and 2098 cm{sup -1} ({nu}5+{nu}14). Inmore » each of the latter four cases, the spectra show complications; in the case of {nu}24, these complications are due to rotational l-type doublings, and in the case of the parallel bands, the spectral complexities are due to Fermi resonance and Coriolis interactions of the upper states with nearby levels. The unraveling of these is underway but the assignment of many of these transitions permit the confident use of the ground state differences in determining the following constants for the ground state (in units of cm{sup -1}): B0 = 0.1394736(2), DJ = 2.458(1) x 10{sup -8}, DJK = 8.28(3) x 10{sup -8}. For the unperturbed {nu}16 fundamental, more than 3000 transitions were fit and the band origin was found to be at 992.53793(2) cm{sup -1}. The numbers in parentheses are the uncertainties (two standard deviations) in the value of the last digit of the constants. Surprisingly, the very accurate B0 value measured here is lower than the value (0.1418 cm{sup -1}) calculated from an electron diffraction structure, instead of being higher, as expected. Where possible, the rovibrational results are compared with those computed at the anharmonic level using the B3LYP density functional method with a cc-pVTZ basis set. These too suggest that the electron diffraction results are in question.« less

Delirium assessment in hospitalized elderly patients: Italian translation and validation of the nursing delirium screening scale.

PubMed

Spedale, Valentina; Di Mauro, Stefania; Del Giorno, Giulia; Barilaro, Monica; Villa, Candida E; Gaudreau, Jean D; Ausili, Davide

2017-08-01

Delirium has a high incidence pathology associated with negative outcomes. Although highly preventable, half the cases are not recognized. One major cause of delirium misdiagnosis is the absence of a versatile instrument to measure it. Our objective was to translate the nursing delirium screening scale (Nu-DESC) and evaluate its performance in Italian settings. This was a methodological study conducted in two sequential phases. The first was the Italian translation of Nu-DESC through a translation and back-translation process. The second aimed to test the inter-rater reliability, the sensibility and specificity of the instrument on a convenience sample of 101 hospitalized elderly people admitted to relevant wards of the San Gerardo Hospital in Monza. To evaluate the inter-rater reliability, two examiners tested Nu-DESC on 20 patients concurrently without comparison. To measure the sensibility and specificity of Nu-DESC, the confusion assessment method was used as a gold standard measure. The inter-rater reliability (Cohen Kappa) was 0.87-an excellent agreement between examiners. The study of the ROC curve showed an AUC value of 0.9461 suggesting high test accuracy. Using 3 as a cut-off value, Nu-DESC showed 100 % sensibility and 76 % specificity. Further research is needed to test Nu-DESC on a larger sample. However, based on our results, Nu-DESC can be used in research and clinical practice in Italian settings because of its very good and similar performances to previous validation studies. The value of 3 appears to be the optimal cut-off in the Italian context.

Measurement of the top quark mass using template methods on dilepton events in p anti-p collisions at s**(1/2) = 1.96-TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abulencia, A.; Acosta, D.; Adelman, Jahred A.

2006-02-01

The authors describe a measurement of the top quark mass from events produced in p{bar p} collisions at a center-of-mass energy of 1.96 TeV, using the Collider Detector at Fermilab. They identify t{bar t} candidates where both W bosons from the top quarks decay into leptons (e{nu}, {mu}{nu}, or {tau}{nu}) from a data sample of 360 pb{sup -1}. The top quark mass is reconstructed in each event separately by three different methods, which draw upon simulated distributions of the neutrino pseudorapidity, t{bar t} longitudinal momentum, or neutrino azimuthal angle in order to extract probability distributions for the top quark mass.more » For each method, representative mass distributions, or templates, are constructed from simulated samples of signal and background events, and parameterized to form continuous probability density functions. A likelihood fit incorporating these parameterized templates is then performed on the data sample masses in order to derive a final top quark mass. Combining the three template methods, taking into account correlations in their statistical and systematic uncertainties, results in a top quark mass measurement of 170.1 {+-} 6.0(stat.) {+-} 4.1(syst.) GeV/c{sup 2}.« less

Dirac neutrinos and SN 1987A

NASA Technical Reports Server (NTRS)

Turner, Michael S.

1991-01-01

Previous work has shown that the cooling of SN 1987A excludes a Dirac-neutrino mass greater than theta(20 keV) for nu(sub e), nu(sub mu), or nu(sub tau). The emission of wrong-helicity, Dirac neutrinos from SN 1987A, is re-examined. It is concluded that the effect of a Dirac neutrino on the cooling of SN 1987A has been underestimated due to neutrino degeneracy and additional emission processes. The limit that follows from the cooling of SN 1987A is believed to be greater (probably much greater) than 10 keV. This result is significant in light of the recent evidence for a 17 keV mass eigenstate that mixes with the electron neutrino.

Congenitally athymic nude (nu/nu) mice have Thy-1-bearing immunocompetent helper T cells in their peritoneal cavity

PubMed Central

1980-01-01

Heavily irradiated peritoneal cells (PC) from congenitally athymic nude (nu/nu) mice markedly restored the impaired in vitro antibody response of nu/nu spleen cells to sheep erythrocyte antigens (T-dependent antigen), whereas irradiated spleen or lymph node cells from nu/nu mice had no effect on the response. This activity of the irradiated PC of nu/nu mice was completely abolished by treatment with anti-Thy-1.2 antiserum plus normal guinea pig serum (C') and is, therefore, attributable to a function of matured T cells. PMID:6966314

Adsorption of a catalytically accessible polyoxometalate in a mesoporous channel-type metal–organic framework

DOE PAGES

Buru, Cassandra T.; Li, Peng; Mehdi, B. Layla; ...

2017-05-24

A Keggin-type polyoxometalate (H 3PW 12O 40) was incorporated into a mesoporous Zr-based MOF (NU-1000) via an impregnation method in aqueous media, resulting in the hybrid material, PW 12@NU-1000. The POM@MOF composite was characterized by a suite of physical methods, indicating the retention of crystallinity and high porosity of the parent MOF. The hybrid material was also stable to leaching in aqueous media at varying pH. Lastly, the material was tested as a heterogeneous catalyst for the oxidation of 2-chloroethyl ethyl sulfide using hydrogen peroxide as the oxidant. PW 12@NU-1000 was shown to have a higher catalytic activity than eithermore » of the individual constituents alone.« less

The three principal secular resonances nu(5), nu(6), and nu(16) in the asteroidal belt

NASA Astrophysics Data System (ADS)

Froeschle, Ch.; Scholl, H.

1989-09-01

Theoretical and numerical results obtained for secular resonant motion in the asteroidal belt are reviewed. William's (1969) theory yields the locations of the principal secular resonances nu(5), Nu(6), and nu(16) in the asteroidal belt. Theories by Nakai and Kinoshita (1985) and by Yoshikawa (1987) make it possible to model the basic features of orbital evolution at the secular resonances nu(16) and nu(6), respectively. No theory is available for the secular resonance nu(5). Numerical experiments by Froeschle and Scholl yield quantitative and new qualitative results for orbital evolutions at the three principal secular resonances nu(5), nu(6), and nu(16). These experiments indicate possible chaotic motion due to overlapping resonances. A secular resonance may overlap with another secular resonance or with a mean motion resonance. The role of the secular resonances as possible sources of meteorites is discussed.

Experimental Air-Broadened Line Parameters in the nu2 Band of CH3D

NASA Technical Reports Server (NTRS)

Cross, Adriana Predoi; Brawley-Tremblay, Shannon; Povey, Chad; Smith, Mary Ann H.

2007-01-01

In this study we report the first experimental measurements of air-broadening and air-induced pressure-shift coefficients for approximately 378 transitions in the nu2 fundamental band of CH3D. These results were obtained from analysis of 17 room temperature laboratory absorption spectra recorded at 0.0056 cm(exp -1) resolution using the McMath-Pierce Fourier transform spectrometer located on Kitt Peak, Arizona. Three absorption cells with path lengths of 10.2, 25 and 150 cm were used to record the spectra. The total sample pressures ranged from 0.129x10(exp -2) to 52.855x10(exp -2) atm with CH3D volume mixing ratios of approximately 0.0109 in air. The spectra were analyzed using a multispectrum non-linear least-squares fitting technique. We report measurements for air pressure-broadening coefficients for transitions with quantum numbers as high as J" = 20 and K = 15, where K" = K' equivalent to K (for a parallel band). The measured air broadening coefficients range from 0.0205 to 0.0835 cm(exp -1) atm(exp -1) at 296 K. All the measured pressure-shift coefficients are negative and are found to vary from about -0.0005 to -0.0080 cm(exp -1) atm(exp -1) at the temperature of the spectra. We have examined the dependence of the measured broadening and shift parameters on the J" and K quantum numbers and also developed empirical expressions to describe the broadening coefficients in terms of m (m = -J", J" and J" + 1 in the (sup Q)P- (sup Q)Q-, and (sup Q)R-branch, respectively) and K. On average, the empirical expressions reproduce the measured broadening coefficients to within 4.4%.

The nu(sub 6), nu(sub 7), nu(sub 8), and nu(sub 10) Bands of HO2NO2

NASA Technical Reports Server (NTRS)

Friedl, Randall R.; May, Randy D.; Duxbury, Geoffrey

1994-01-01

Two new fundamental vibration-rotation bands have been observed for HO2NO2 and assigned. They are nu(sub 7) at 648 1/cm and nu(sub 8) at 466 1/cm. On the basis of these assignments the previously observed bands at 722, 801.5, and 919 1/cm are assigned to nu(sub 10), nu(sub 7) + nu(sub 12), and 2 nu(sub 8), respectively. A partial rotational analysis of the atmospherically relevant nu(sub 6) band has been carried out, and the effects of tunneling, Coriolis interactions, and hot bands on the rotational structure have been characterized.The band origin derived from this analvsisis 8O2.54(sub 3) 1/cm.

Perioperative outcomes of 6042 nephrectomies in 2012: surgeon-reported results in the UK from the British Association of Urological Surgeons (BAUS) nephrectomy database.

PubMed

Henderson, John M; Fowler, Sarah; Joyce, Adrian; Dickinson, Andrew; Keeley, Francis X

2015-01-01

To present the perioperative outcomes from the British Association of Urological Surgeons (BAUS) nephrectomy dataset for 2012, the first year of public reporting of individual surgeon outcomes in the UK. All nephrectomies performed in the year 2012 and recorded in the database were analysed. These were divided into simple nephrectomy (SN), partial nephrectomy (PN), radical nephrectomy (RN), and nephroureterectomy (NU). The estimated capture rate for nephrectomy was 80%. The outcomes measured were 30-day mortality (30-DM), Clavien-Dindo complications grade ≥III, blood transfusion, conversion to open, and length of stay. The overall 30-DM was 0.55% (SN 0.53%; PN 0.10%; RN 0.52%; NU 1.27%). Clavien-Dindo complications grade ≥III were recorded in 3.9% of nephrectomies (SN 4.3%; PN 5.4%; RN 3.1%; NU 4.5%). Blood transfusion was required during surgical admission for 8.4% of nephrectomies (SN 5.2%; PN 3.4%; RN 11.1%; NU 8.3%). Conversion to open was carried out in 5.5% of minimally invasive nephrectomies (SN 6.1%; PN 4.0%; RN 5.5%; NU 5.6%). Open nephrectomy patients remained in hospital for a median of 6 days (SN 7; PN 5; RN 7; NU 8 days), which was higher than the median 4-day stay (SN 3; PN 4; RN 4; NU 5 days) for minimally invasive surgery. Nephrectomy in 2012 was a safe procedure with morbidity and mortality rates comparable with or less than published series. The collection of surgeon-specific data should be iterative with further refinement of data categories, support for the collection process and independent validation of results. © 2014 The Authors. BJU International © 2014 BJU International.

ASTEROSEISMOLOGY OF RED GIANTS FROM THE FIRST FOUR MONTHS OF KEPLER DATA: GLOBAL OSCILLATION PARAMETERS FOR 800 STARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huber, D.; Bedding, T. R.; Stello, D.

2010-11-10

We have studied solar-like oscillations in {approx}800 red giant stars using Kepler long-cadence photometry. The sample includes stars ranging in evolution from the lower part of the red giant branch to the helium main sequence. We investigate the relation between the large frequency separation ({Delta}{nu}) and the frequency of maximum power ({nu}{sub max}) and show that it is different for red giants than for main-sequence stars, which is consistent with evolutionary models and scaling relations. The distributions of {nu}{sub max} and {Delta}{nu} are in qualitative agreement with a simple stellar population model of the Kepler field, including the first evidencemore » for a secondary clump population characterized by M {approx}> 2 M{sub sun} and {nu}{sub max} {approx_equal} 40-110 {mu}Hz. We measured the small frequency separations {delta}{nu}{sub 02} and {delta}{nu}{sub 01} in over 400 stars and {delta}{nu}{sub 03} in over 40. We present C-D diagrams for l = 1, 2, and 3 and show that the frequency separation ratios {delta}{nu}{sub 02}/{Delta}{nu} and {delta}{nu}{sub 01}/{Delta}{nu} have opposite trends as a function of {Delta}{nu}. The data show a narrowing of the l = 1 ridge toward lower {nu}{sub max}, in agreement with models predicting more efficient mode trapping in stars with higher luminosity. We investigate the offset {epsilon} in the asymptotic relation and find a clear correlation with {Delta}{nu}, demonstrating that it is related to fundamental stellar parameters. Finally, we present the first amplitude-{nu}{sub max} relation for Kepler red giants. We observe a lack of low-amplitude stars for {nu}{sub max} {approx}> 110 {mu}Hz and find that, for a given {nu}{sub max} between 40 and 110 {mu}Hz, stars with lower {Delta}{nu} (and consequently higher mass) tend to show lower amplitudes than stars with higher {Delta}{nu}.« less

Raman spectroscopy and melting of nitrogen between 290 and 900 K and 2. 3 and 18 GPa

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zinn, A.S.; Schiferl, D.; Nicol, M.F.

1987-07-15

Raman spectroscopy was used to study the melting of nitrogen from 290 to 900 K at pressures from 2.3 to 18 GPa. This work, which extends the melting by a factor of 9 over previously published results was made possible by new developments in high-temperature diamond-anvil cells. The ..beta../delta phase boundary was also determined, and the ..beta..--delta--fluid triple point was found to be at 578 +- 10 K and 9.9 +- 0.5 GPa. The Raman frequencies of the vibron in fluid N/sub 2/ and the ..nu../sub 2/ vibron in delta-N/sub 2/ were found to have the same pressure dependence andmore » be independent of temperature to a good approximation. A temperature-independent pressure scale, useful to at least 900 K is approximated by P/GPa = 0.4242 ..nu../cm/sup -1/ -987.8, where ..nu.. is the frequency of either the ..nu../sub 2/ vibron in delta-N/sub 2/ or the vibron in fluid-N/sub 2/.« less

A Scalable Cloud Library Empowering Big Data Management, Diagnosis, and Visualization of Cloud-Resolving Models

NASA Astrophysics Data System (ADS)

Zhou, S.; Tao, W. K.; Li, X.; Matsui, T.; Sun, X. H.; Yang, X.

2015-12-01

A cloud-resolving model (CRM) is an atmospheric numerical model that can numerically resolve clouds and cloud systems at 0.25~5km horizontal grid spacings. The main advantage of the CRM is that it can allow explicit interactive processes between microphysics, radiation, turbulence, surface, and aerosols without subgrid cloud fraction, overlapping and convective parameterization. Because of their fine resolution and complex physical processes, it is challenging for the CRM community to i) visualize/inter-compare CRM simulations, ii) diagnose key processes for cloud-precipitation formation and intensity, and iii) evaluate against NASA's field campaign data and L1/L2 satellite data products due to large data volume (~10TB) and complexity of CRM's physical processes. We have been building the Super Cloud Library (SCL) upon a Hadoop framework, capable of CRM database management, distribution, visualization, subsetting, and evaluation in a scalable way. The current SCL capability includes (1) A SCL data model enables various CRM simulation outputs in NetCDF, including the NASA-Unified Weather Research and Forecasting (NU-WRF) and Goddard Cumulus Ensemble (GCE) model, to be accessed and processed by Hadoop, (2) A parallel NetCDF-to-CSV converter supports NU-WRF and GCE model outputs, (3) A technique visualizes Hadoop-resident data with IDL, (4) A technique subsets Hadoop-resident data, compliant to the SCL data model, with HIVE or Impala via HUE's Web interface, (5) A prototype enables a Hadoop MapReduce application to dynamically access and process data residing in a parallel file system, PVFS2 or CephFS, where high performance computing (HPC) simulation outputs such as NU-WRF's and GCE's are located. We are testing Apache Spark to speed up SCL data processing and analysis.With the SCL capabilities, SCL users can conduct large-domain on-demand tasks without downloading voluminous CRM datasets and various observations from NASA Field Campaigns and Satellite data to a local computer, and inter-compare CRM output and data with GCE and NU-WRF.

Infrared and Microwave Spectra and Force Field of DBO: The Coriolis Interaction between the nu1 and nu2 + nu3 States.

PubMed

Kawashima; Colarusso; Zhang; Bernath; Hirota

1998-11-01

The nu1 and nu3 bands of D11BO and the nu1 band of D10BO were observed by using an infrared diode laser spectrometer. The DBO molecule was generated by an ac discharge in a mixture of BCl3, D2, O2, and He. As inferred previously, a strong Coriolis interaction was in fact found to take place between the nu1 and nu2 + nu3 states, and an analysis of the observed nu1 spectra, which explicitly took into account this Coriolis interaction, predicted the pure rotational transition frequencies of DBO in the nu1 state. Pure rotational lines were then detected by microwave spectroscopy, confirming the validity of the infrared assignment. In the microwave experiment DBO molecules were generated by a discharge in a mixture of B2D6 and O2. The three fundamental bands and a hot band of D11BO, as well as the nu1 and nu3 bands of D10BO, were subsequently recorded in emission with a Fourier transform infrared spectrometer. DBO molecules were generated by the reaction of D2 with HBO at temperatures above 800 degreesC in a ceramic tube furnace. All of the observed spectra were simultaneously subjected to a least-squares analysis to obtain molecular parameters in the ground, nu1, nu2, nu3, and nu2 + nu3 states. The results thus obtained improved the force field and molecular structure of the HBO/DBO molecules reported in a previous study (Y. Kawashima, Y. Endo, and E. Hirota, 1989, J. Mol. Spectrosc. 133, 116-127). Copyright 1998 Academic Press.

Point Processes.

DTIC Science & Technology

1987-05-01

O and N(B) < - a.s. for each BEMA. (ii) N(U Bn) = N(Bn) a.s. for any disjoint BI.B 2 .. in ’ R . n n The random variable N(A) represents the number...P(N’(B) = 0). B E o . (C) If (v.X1 X2 ....) (v.Xi.X .. ). then N d N’. The converse is true when E = R + or R and the X ’s are the ordered T ’s.+ n n... R + that are continuous and such that (x: f(x)> O ) is a bounded set. Theorem 1.4. Suppose N and N’ are point processes on E. The following statements

Performance characteristics of NuVal and the Overall Nutritional Quality Index (ONQI).

PubMed

Katz, David L; Njike, Valentine Y; Rhee, Lauren Q; Reingold, Arthur; Ayoob, Keith T

2010-04-01

Improving diets has considerable potential to improve health, but progress in this area has been limited, and advice to increase fruit and vegetable intake has largely gone unheeded. Our objective was to test the performance characteristics of the Overall Nutritional Quality Index (ONQI), a tool designed to help improve dietary patterns one well-informed choice at a time. The ONQI was developed by a multidisciplinary group of nutrition and public health scientists independent of food industry interests and is the basis for the NuVal Nutritional Guidance System. Dietary guidelines, existing nutritional scoring systems, and other pertinent scientific literature were reviewed. An algorithm incorporating >30 entries that represent both micro- and macronutrient properties of foods, as well as weighting coefficients representing epidemiologic associations between nutrients and health outcomes, was developed and subjected to consumer research and testing of performance characteristics. ONQI and expert panel rankings correlated highly (R = 0.92, P < 0.001). In consumer testing, approximately 80% of >800 study participants indicated that the ONQI would influence their purchase intent. ONQI scoring distinguished the more-healthful DASH (Dietary Approaches to Stop Hypertension) diet (mean score: 46) from the typical American diet according to the National Health and Nutrition Examination Survey (NHANES) 2003-2006 (mean score: 26.5; P < 0.01). In linear regression analysis of the NHANES 2003-2006 populations (n = 15,900), the NuVal system was significantly associated with the Healthy Eating Index 2005 (P < 0.0001). Recently generated data from ongoing studies indicate favorable effects on purchase patterns and significant correlation with health outcomes in large cohorts of men and women followed for decades. NuVal offers universally applicable nutrition guidance that is independent of food industry interests and is supported by consumer research and scientific evaluation of its performance characteristics.

Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand.

PubMed

Kularatne, Sumith A; Wang, Kevin; Santhapuram, Hari-Krishna R; Low, Philip S

2009-01-01

Prostate cancer (PCa) is a major cause of mortality and morbidity in Western society today. Current methods for detecting PCa are limited, leaving most early malignancies undiagnosed and sites of metastasis in advanced disease undetected. Major deficiencies also exist in the treatment of PCa, especially metastatic disease. In an effort to improve both detection and therapy of PCa, we have developed a PSMA-targeted ligand that delivers attached imaging and therapeutic agents selectively to PCa cells without targeting normal cells. The PSMA-targeted radioimaging agent (DUPA-(99m)Tc) was found to bind PSMA-positive human PCa cells (LNCaP cell line) with nanomolar affinity (K(D) = 14 nM). Imaging and biodistribution studies revealed that DUPA-(99m)Tc localizes primarily to LNCaP cell tumor xenografts in nu/nu mice (% injected dose/gram = 11.3 at 4 h postinjection; tumor-to-muscle ratio = 75:1). Two PSMA-targeted optical imaging agents (DUPA-FITC and DUPA-rhodamine B) were also shown to efficiently label PCa cells and to internalize and traffic to intracellular endosomes. A PSMA-targeted chemotherapeutic agent (DUPA-TubH) was demonstrated to kill PSMA-positive LNCaP cells in culture (IC(50) = 3 nM) and to eliminate established tumor xenografts in nu/nu mice with no detectable weight loss. Blockade of tumor targeting upon administration of excess PSMA inhibitor (PMPA) and the absence of targeting to PSMA-negative tumors confirmed the specificity of each of the above targeted reagents for PSMA. Tandem use of the imaging and therapeutic agents targeted to the same receptor could allow detection, staging, monitoring, and treatment of PCa with improved accuracy and efficacy.

Rapidities of produced particles in 200-GeV/ c. pi. sup + /p/K sup + interactions on Au, Ag, and Mg

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brick, D.H.; Widgoff, M.; Beilliere, P.

1990-02-01

We have used the Fermilab 30-in. bubble chamber--hybrid spectrometer to study the rapidities of produced particles'' in the interactions of 200-GeV/{ital c} protons and {pi}{sup +} and {ital K}{sup +} mesons with nuclei of gold, silver, and magnesium. The average rapidity decreases linearly with the number of projectile collisions {nu}{sub {ital p}} (up to {nu}{sub {ital p}}=5) with no {ital A} dependence and little beam dependence. The ratio {ital R} of normalized rapidity distributions for hadron-nucleus to hadron-proton interactions shows a plateau in the central region, and becomes much larger in the target region. However, the increase is significantly lessmore » than has been reported in previous experiments. As a function of {nu}{sub {ital p}}, the ratio {ital R} rises linearly in the target region, more gently in the central region, and decreases slowly in the projectile region, in all cases with no {ital A} dependence. Some discrepancies with a previous experiment are observed in the central region. Long-range rapidity correlations are observed in hadron-nucleus events, but not in hadron-proton events. For the former, it is shown that the correlations exist only for those events with multiple projectile collisions, as expected in the multichain dual parton model.« less

Hybridomas using athymic nude mouse injected with Crohn's disease (CD) tissue filtrate. Immunoreactivity of the hybridomas with CD sera.

PubMed Central

Das, K. M.; Vecchi, M.; Novikoff, A.; Mazumdar, S.; Novikoff, P. M.

1990-01-01

Injections of Crohn's disease (CD) tissue filtrates produce lymphoma and hyperplastic lymph nodes from plasma cell hyperplasia (PCH) in athymic nude (nu/nu) mice; these lymphoid tissue contain an antigen(s) recognized by CD serum/gamma G immunoglobulin (IgG). To immortalize the "CD-reactive antigen(s)," the authors fused the lymphoid cells from a CD tissue filtrate primed nu/nu mouse with nonsecretory mouse myeloma cells. Hybrids were screened and selected based on their reactivity with CD serum IgG, but not with control serum IgG in an indirect immunofluorescence assay (IF). Two CD-positive hybridomas were examined by IF with sera from 47 CD, 38 ulcerative colitis (UC), 13 controls with other gastrointestinal diseases, 19 with autoimmune diseases, and 21 normal subjects. Sera from 16 CD patients (34%) reacted with the two hybridomas, but only one of 38 UC sera and none of the 53 other disease or normal control sera reacted. The immunoreactivity of CD sera was significantly higher than UC sera (P less than 0.01) and each of the other groups (P less than 0.007). Using immunoperoxidase techniques at light and electron microscopic levels, the authors localized CD-associated antigen(s) in the plasma membrane of the two hybridomas. Further characterization of these hybridomas and the immunoreactive protein(s) may provide an important probe(s) for the diagnosis and the understanding of the pathogenesis of CD. Images Figure 2 Figure 3 PMID:2192559

Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal.

PubMed

Marino, Susan; Nusse, Roel

2007-06-13

The NuRD/Mi2 chromatin complex is involved in histone modifications and contains a large number of subunits, including the p66 protein. There are two mouse and human p66 paralogs, p66alpha and p66beta. The functions of these genes are not clear, in part because there are no mutants available, except in invertebrate model systems. We made loss of function mutants in the mouse p66alpha gene (mp66alpha, official name Gatad2a, MGI:2384585). We found that mp66alpha is essential for development, as mutant embryos die around day 10 of embryogenesis. The gene is not required for normal blastocyst development or for implantation. The phenotype of mutant embryos and the pattern of gene expression in mutants are consistent with a role of mp66alpha in gene silencing. mp66alpha is an essential gene, required for early mouse development. The lethal phenotype supports a role in execution of methylated DNA silencing.

[Thymus dependent immunity against Tyzzer's disease in the mouse].

PubMed

Fujiwara, K; Machii, K; Nakayama, M; Tamura, T; Ueda, K

1977-01-01

Nude (nu/nu) mice fail to resist to challenge infection of Tyzzer's disease after pretreatment with formalin-killed organisms that was effective for protecting heterozygous haired (nu/ł) mice from challenge. Resistance was induced nu/nu mice after the transfer of spleen cells from immunized nu/ł and concomitant formalin vaccine treatment.

Microbiological Investigations of ReNu Plastic Bottles and the 2004 to 2006 ReNu With MoistureLoc-Related Worldwide Fusarium Keratitis Event.

PubMed

Bullock, John D; Warwar, Ronald E; Elder, B Laurel; Khamis, Harry J

2016-05-01

The purposes of this study were to determine whether the contact lens solution RevitaLens Ocutec (containing the antimicrobial agents alexidine and polyquaternium-1) would inhibit Fusarium organisms when heated in ReNu plastic bottles; whether alexidine would inhibit Fusarium organisms when heated in non-ReNu plastic bottles; and whether an alexidine-neutralizing compound leaches from heated ReNu bottles. RevitaLens and an alexidine solution (0.00045%), previously stored in ReNu bottles at room temperature (RT) and 56°C, were incubated with 7 different Fusarium organisms. The alexidine solution was similarly stored in seven non-ReNu plastic bottles and incubated with these same organisms. To determine if an alexidine-neutralizing compound might be leaching from heated ReNu bottles, phosphate-buffered saline (PBS) was incubated at RT and 56°C in ReNu bottles, combined with alexidine, and then tested for anti-Fusarium capability. After being heated in ReNu bottles, RevitaLens retained its anti-Fusarium capability, whereas the alexidine solution did not. The alexidine solution heated in seven non-ReNu plastic bottles retained its anti-Fusarium capability. The alexidine solution retained its anti-Fusarium capability when incubated with a PBS solution that had been heated in ReNu bottles, indicating, microbiologically, that an alexidine-neutralizing compound did not leach from the heated ReNu bottle. Alexidine uniquely fails to inhibit Fusarium organisms when heated in a plastic ReNu bottle, but not in seven other plastic bottles, whereas the anti-Fusarium capability of RevitaLens (containing the antimicrobial agents alexidine and polyquaternium-1) is unaffected by heating in a ReNu bottle. There does not seem to be an alexidine-neutralizing compound leaching from heated ReNu bottles. An interaction between alexidine and its heated ReNu bottle may have been a critical factor in the worldwide ReNu with MoistureLoc-related Fusarium keratitis event of 2004 to 2006.

Evaluation of Diagnostic CO2 Flux and Transport Modeling in NU-WRF and GEOS-5

NASA Astrophysics Data System (ADS)

Kawa, S. R.; Collatz, G. J.; Tao, Z.; Wang, J. S.; Ott, L. E.; Liu, Y.; Andrews, A. E.; Sweeney, C.

2015-12-01

We report on recent diagnostic (constrained by observations) model simulations of atmospheric CO2 flux and transport using a newly developed facility in the NASA Unified-Weather Research and Forecast (NU-WRF) model. The results are compared to CO2 data (ground-based, airborne, and GOSAT) and to corresponding simulations from a global model that uses meteorology from the NASA GEOS-5 Modern Era Retrospective analysis for Research and Applications (MERRA). The objective of these intercomparisons is to assess the relative strengths and weaknesses of the respective models in pursuit of an overall carbon process improvement at both regional and global scales. Our guiding hypothesis is that the finer resolution and improved land surface representation in NU-WRF will lead to better comparisons with CO2 data than those using global MERRA, which will, in turn, inform process model development in global prognostic models. Initial intercomparison results, however, have generally been mixed: NU-WRF is better at some sites and times but not uniformly. We are examining the model transport processes in detail to diagnose differences in the CO2 behavior. These comparisons are done in the context of a long history of simulations from the Parameterized Chemistry and Transport Model, based on GEOS-5 meteorology and Carnegie Ames-Stanford Approach-Global Fire Emissions Database (CASA-GFED) fluxes, that capture much of the CO2 variation from synoptic to seasonal to global scales. We have run the NU-WRF model using unconstrained, internally generated meteorology within the North American domain, and with meteorological 'nudging' from Global Forecast System and North American Regional Reanalysis (NARR) in an effort to optimize the CO2 simulations. Output results constrained by NARR show the best comparisons to data. Discrepancies, of course, may arise either from flux or transport errors and compensating errors are possible. Resolving their interplay is also important to using the data in inverse models. Recent analysis is focused on planetary boundary depth, which can be significantly different between MERRA and NU-WRF, along with subgrid transport differences. Characterization of transport differences between the models will allow us to better constrain the CO2 fluxes, which is the major objective of this work.

Using Electronic Data Interchange to Report Product Quality

DTIC Science & Technology

1993-03-01

Numbers 0 31.1 S........................ . . . . ........... .... . .--- . ... N/U 140 SPS Sampling Parameters for Summary Statistics 0 1 N/U 150 REF...DTM Date/Time Reference 0 1 N/U 190 REF Reference Numbers 021 .................................. .......... .. ... NAU 200 STA Statistics 0 1 N/U 210...Measurements 0 1 N/U 120 DTM Date/Time Reference 0 >1 N/U 130 REF Reference Numbers 0 >1 :LOOIV f-SPS N/U 140 SPS Sampling Parameters for Summary Statistics 0 1

Pleiotropy in microdeletion syndromes: Neurologic and spermatogenic abnormalities in mice homozygous for the p{sup 6H} deletion are likely due to dysfunction of a single gene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rinchik, E.M.; Carpenter, D.A.; Handel, M.A.

1995-07-03

Variability and complexity of phenotypes observed in microdeletion syndromes can be due to deletion of a single gene whose product participates in several aspects of development or can be due to the deletion of a number of tightly linked genes, each adding its own effect to the syndrome. The p{sup 6H} deletion in mouse chromosome 7 presents a good model with which to address this question of multigene vs. single-gene pleiotropy. Mice homozygous for the p{sup 6H} deletion are diluted in pigmentation, are smaller than their littermates, and manifest a nervous jerky-gait phenotype. Male homozygotes are sterile and exhibit profoundmore » abnormalities in spermiogenesis. By using N-ethyl-N-nitrosourea (EtNU) mutagenesis and a breeding protocol designed to recover recessive mutations expressed hemizygously opposite a large p-locus deletion, we have generated three noncomplementing mutations that map to the p{sup 6H} deletion. Each of these EtNU-induced mutations has adverse effects on the size, nervous behavior, and progression of spermiogenesis that characterize p{sup 6H} deletion homozygotes. Because etNU is thought to induce primarily intragenic (point) mutations in mouse stem-cell spermatogonia, we propose that the trio of phenotypes (runtiness, nervous jerky gait, and male sterility) expressed in p{sup 6H} deletion homozygotes is the result of deletion of a single highly pleiotropic gene. We also predict that a homologous single locus, quite possibly tightly linked and distal to the D15S12 (P) locus in human chromosome 15q11-q13, may be associated with similar developmental abnormalities in humans. 29 refs., 3 figs., 1 tab.« less

Sequential dome-collapse nuées ardentes analyzed from broadband seismic data, Merapi Volcano, Indonesia

USGS Publications Warehouse

Brodscholl, A.; Kirbani, S.B.; Voight, B.

2000-01-01

The broadband data were evaluated using the assumption that avalanches with the same source areas and descent paths exhibit a linear relation between source volume and recorded seismic-amplitude envelope area. A result of the analysis is the determination of the volume of selected individual events. From the field surveys, the total volume of the collapsed dome lava is 2.6 Mm3. Discounting the volumetric influence of rockfalls, the average size of the 44 nuées ardentes is therefore about 60,000 m3. The largest collapse event at 10:54 is estimated to involve 260,000 m3, based on an analysis of the seismicity. The remaining 23 phase I events averaged 60,000 m3, with the total volume of all phase I events accounting for 63% of the unstable dome. The 20 phase II events comprised 37% of the total volume and averaged 47,000 m3. The methods described here can be put to practical use in real-time monitoring situations. Broadband data were essential in this study primarily because of the wide dynamic range.

Computational Study of a Vortex-Ring Pair Interacting with a Constant-Temperature Heated Wall

NASA Astrophysics Data System (ADS)

Jabbar, Hussam; Naguib, Ahmed

2017-11-01

Impinging jets are used widely in industrial and manufacturing processes because of their ability to increase the heat transfer rate from the impingement surface. The vortical structures of these jets have an important influence on the heat transfer; by affecting the thermal boundary layer (TBL) during their interaction with the wall. In order to better understand the physics of this interaction, particularly when pairing of two vortices happens near the wall, a simplified model problem of two isolated vortex rings interacting with a flat wall is investigated computationally using ANSYS FLUENT 17.1. Observations of the vorticity field, the temperature field, the wall shear stress, the TBL and the Nusselt number (Nu) provide insight into the association of local Nu maxima/minima with different flow features. The results provide physical understanding of the flow processes leading to enhancement/deterioration of Nu due to vortex-wall interaction. Additionally, the characteristics of the vortical structures are quantified, and possible correlations between the temporal development of these characteristics and the evolution of the maximum/minimum Nu are investigated. The results are compared to those involving a single vortex ring in order to understand the effect of vortex pairing. This work is supported by NSF Grant Number CBET-1603720. Hussam Jabbar also acknowledges the fellowship support from Higher Committee for Education Development in Iraq (HCED).

Metal–organic framework supported cobalt catalysts for the oxidative dehydrogenation of propane at low temperature

DOE PAGES

Li, Zhanyong; Peters, Aaron W.; Bernales, Varinia; ...

2016-11-30

Here, Zr-based metal–organic frameworks (MOFs) have been shown to be excellent catalyst supports in heterogeneous catalysis due to their exceptional stability. Additionally, their crystalline nature affords the opportunity for molecular level characterization of both the support and the catalytically active site, facilitating mechanistic investigations of the catalytic process. We describe herein the installation of Co(II) ions to the Zr 6 nodes of the mesoporous MOF, NU-1000, via two distinct routes, namely, solvothermal deposition in a MOF (SIM) and atomic layer deposition in a MOF (AIM), denoted as Co-SIM+NU-1000 and Co-AIM+NU-1000, respectively. The location of the deposited Co species in themore » two materials is determined via difference envelope density (DED) analysis. Upon activation in a flow of O 2 at 230 °C, both materials catalyze the oxidative dehydrogenation (ODH) of propane to propene under mild conditions. Catalytic activity as well as propene selectivity of these two catalysts, however, is different under the same experimental conditions due to differences in the Co species generated in these two materials upon activation as observed by in situ X-ray absorption spectroscopy. A potential reaction mechanism for the propane ODH process catalyzed by Co-SIM+NU-1000 is proposed, yielding a low activation energy barrier which is in accord with the observed catalytic activity at low temperature.« less

[Prophylactic and therapeutic effect of oxymatrine on D-galactosamine-induced rat liver fibrosis].

PubMed

Yang, Wenzhuo; Zeng, Minde; Fan, Zhuping; Mao, Yimin; Song, Yulin; Jia, Yitao; Lu, Lungen; Chen, Cheng Wei; Peng, Yan Shen; Zhu, Hong Yin

2002-06-01

To investigate the prophylactic and therapeutic effect of oxymatrine on experimental liver fibrosis and to reveal its mechanism. By establishing D-galactosamine-induced rat liver fibrosis model, we observed the effect of oxymatrine on serum and tissue biochemical indexes, content of liver hydroxyline, expression of TGF?1 mRNA and changes of tissue pathology. There was a decline of liver hydroxyline and serum AST and ALT in oxymatrine group compared to those of the D-GalN group. The hydroxyline content in oxymatrine pretreatment group was (0.50 0.11)mug/mg compared with (0.99 0.14)mug/mg in D-GalN group (t=8.366, P<0.01). The content in oxymatrine treatment group was (0.44 0.04)mug/mg compared with 0.70 0.06 in D-GalN group (t=9.839, P<0.01). The SOD activity was (149.81 15.28) NU/mg in oxymatrine pretreatment group and (95.22 16.33) NU/mg in the model group (t=7.309, P<0.01); (157.68 19.54) NU/mg in the treatment group compared with (119.88 14.94) NU/mg in the model group (t=4.348, P<0.01). MDA in the pretreatment group was (2.06 0.17) nmol/mg, lower than (4.57 0.37) nmol/mg in the model group (t=17.529, P<0.01). In the treatment group, it was (1.76 0.24)nmol/mg, lower than (3.10 0.17) nmol/mg in the model group (t=12.697, P<0.01). TGF?1 mRNA reduced in the pretreatment and treatment groups as compared with that in the model group (0.21 0.01 vs 0.50 0.01, t=48.665, P<0.01; 0.18 0.02 vs 0.38 0.01, t=22.464, P<0.01). Electron microscopy showed that oxymatrine group had milder hepatocyte degeneration and less fibrosis accumulation than did the model group. Microscopy revealed wide septa expansion from the portal area to the central venous, piecemeal and confluent necrosis and pseudo-nodular formation in part of the lobular in the model group. While in oxymatrine group these lesions were much improved. Oxymatrine shows prophylactic and therapeutic effect in D-galactosamine induced rat liver fibrosis. This is partly by protecting hepatocyte and suppressing fibrosis accumulation through anti-lipoperoxidation.

[Effects of hypoxia inducible factor-2α on promoting angiogenesis of residual hepatocellular carcinoma after high-intensity focused ultrasound ablation].

PubMed

Wu, Lun; Zhou, Wenbo; Zhou, Shiji; Liu, Chang'an; Li, Shengwei

2015-02-01

To investigate the dynamic features of angiogenesis in residual tumors after high intensity focused ultrasound (HIFU),and to determine the temporal effect and mechanism of hypoxia inducible factor-2 alpha (HIF-2a) in the angiogenic process of residual tumors. Xenograft tumors of HepG2 cells were generated by subcutaneously inoculating athymic BALB/c nu/nu mice with the hepatoma cells.About 30 days after inoculation,all mice (except in the control group) were treated by HIFU and assigned randomly to the following 7 groups according to various time intervals post-treatment:1st,3rd,5th day and 1st,2nd,3rd,4th week when the residual tumor tissues were obtained from the experimental groups.Protein levels of HIF-2a and vascular growth factor A (VEGF-A) were quantified by immunohistochemistry and western blotting,and mRNA levels were measured by (real-time quantitative) qPCR. Microvascular density (MVD) was calculated by counting the CD31-positive vascular endothelial cells identified by means of an immunohistochemical staining method. Compared with results from the control group,the protein and mRNA levels of HIF-2a expression reached the highest level in the experimental mice at the 2nd week (P=0.000 and P < 0.01 respectively),and were decreased thereafter(3rd week and 4th week, P=0.000 and P < 0.05).VEGF-A expression in the residual tumor tissues group that received HIFU was significantly decreased,compared with the control group,at all time points uPto 1 week (all P=0.000 and P < 0.01),but the levels increased compared to controls in the 2nd through 4th week (all P=0.000, P < 0.05). Similar results were obtained for MVD. HIFU treatment can inhibit angiogenesis in residual hepatoma tissues in the short-term (1 to 2 weeks post-treatment) in mice with hepatocellular carcinoma,but can promote angiogenesis overtime (2 to 4 weeks post-treatment); the angiogenic process may involve the HIF-2α/VEGFA pathway.

Relaxation Dynamics in Heme Proteins.

NASA Astrophysics Data System (ADS)

Scholl, Reinhard Wilhelm

A protein molecule possesses many conformational substates that are likely arranged in a hierarchy consisting of a number of tiers. A hierarchical organization of conformational substates is expected to give rise to a multitude of nonequilibrium relaxation phenomena. If the temperature is lowered, transitions between substates of higher tiers are frozen out, and relaxation processes characteristic of lower tiers will dominate the observational time scale. This thesis addresses the following questions: (i) What is the energy landscape of a protein? How does the landscape depend on the environment such as pH and viscosity, and how can it be connected to specific structural parts? (ii) What relaxation phenomena can be observed in a protein? Which are protein specific, and which occur in other proteins? How does the environment influence relaxations? (iii) What functional form best describes relaxation functions? (iv) Can we connect the motions to specific structural parts of the protein molecule, and are these motions important for the function of the protein?. To this purpose, relaxation processes after a pressure change are studied in carbonmonoxy (CO) heme proteins (myoglobin-CO, substrate-bound and substrate-free cytochrome P450cam-CO, chloroperoxidase-CO, horseradish peroxidase -CO) between 150 K and 250 K using FTIR spectroscopy to monitor the CO bound to the heme iron. Two types of p -relaxation experiments are performed: p-release (200 to ~eq40 MPa) and p-jump (~eq40 to 200 MPa) experiments. Most of the relaxations fall into one of three groups and are characterized by (i) nonexponential time dependence and non-Arrhenius temperature dependence (FIM1( nu), FIM1(Gamma)); (ii) exponential time dependence and non-Arrhenius temperature dependence (FIM0(A_{i}to A_{j})); exponential time dependence and Arrhenius temperature dependence (FIMX( nu)). The influence of pH is studied in myoglobin-CO and shown to have a strong influence on the substate population of the highest tier, tier 0, but not on the relaxation rates. Two different viscosities in myoglobin-CO are compared. The dependence of relaxations on the thermodynamic history of a sample is shown. For substrate-free P450cam-CO, relaxations after a p-jump are observed far above the glass transition of the protein-solvent system.

Obesity is an independent prognostic factor of decreased pathological complete response to neoadjuvant chemotherapy in breast cancer patients.

PubMed

Karatas, Fatih; Erdem, Gokmen Umut; Sahin, Suleyman; Aytekin, Aydin; Yuce, Deniz; Sever, Ali R; Babacan, Taner; Ates, Ozturk; Ozisik, Yavuz; Altundag, Kadri

2017-04-01

The relation between higher body mass index (BMI) and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer (BC) is a controversial issue according to the data of Western and Asian patients. The aim of this study is to evaluate BMI and pCR to NAC and discuss the importance of pCR outcomes in Turkish BC patients as a bridging country between Europe and Asia. Of the 4423 BC patients diagnosed between the years 1994 and 2015 in Hacettepe University Cancer Institute, 295 female patients with stage II and III BC were enrolled in the study. Three different group divisions were done according to patients' BMI as normal or underweight (N/U) patients (BMI <25 kg/m 2 ), overweight (OW) patients (BMI = 25-29.9 kg/m 2 ) and obese (OB) patients (BMI ≥30 kg/m 2 ). BC subtypes were defined as luminal-like (ER/PR-positive and HER2-negative), HER2/luminal (ER/PR-positive and HER2-positive), HER2-type (ER/PR-negative and HER2-positive), and triple-negative (TNBC; ER/PR- and HER2-negative). The analysis of overall survival (OS) and recurrence-free survival (RFS) was performed according to Kaplan-Meier method. The Log-rank test was used to compare the subgroup analysis and logistic regression analysis to determine the independent prognostic factors. In this study, a total number of 93 (31.5%) patients were N/U, 107 (36.3%) patients were OW and 95 (32.2%) patients were OB. Among groups, except for the age, no baseline clinicopathological differences were found. In 70 (23.7%) patients, pCR was achieved. pCR rates in N/U, OW and OB were 31.2%, 22.4%, and 17.9% respectively, showing a considerable trend towards significance (P = 0.09 in chi-square test). In the multivariate logistic regression analysis, obesity was an independent adverse prognostic feature on pCR to NAC compared to N/U patients (OR, 0.34; 95% CI, 0.13 to 0.85, P = 0.02). The recurrence rates were slightly increased with the increase of BMI (N/U = 24.7%, OW = 29.0% and OB = 40%; P = 0.06 respectively). Median RFS was significantly higher in N/U group compared to OB patients (150 vs. 76 months respectively, P = 0.03) and was also higher in pCR group compared to non-pCR patients (151 vs. 77 months P = 0.004). Median OS was significantly higher in N/U patients compared to OB patients (N/U = not reached, OW = 211 and OB = 114 months; P = 0.01) and was also higher in pCR group compared to non-pCR patients (not reached vs. 211 months P = 0.04). In Cox regression analysis; pCR, histopathological grade and TNBC were found as independent prognostic factors on OS (HR, 0.29; 95% CI, 0.11 to 0.79, P = 0.015, HR, 2.09; 95% CI, 1.14 to 3.83, P = 0.017, HR, 1.95; 95% CI, 1.01 to 3.77, P = 0.046, respectively). It was observed that obesity was an important independent prognostic factor which has an adverse effect on pCR. Moreover it causes decreasing RFS and OS in BC patients who had received NAC. The probability of inefficient treatment in obese patients should be considered. Copyright © 2016 Elsevier Ltd. All rights reserved.

The nu-process

NASA Technical Reports Server (NTRS)

Woosley, S. E.; Hartmann, D. H.; Hoffman, R. D.; Haxton, W. C.

1990-01-01

As the core of a massive star collapses to form a neutron star, the flux of neutrinos in the overlying shells of heavy elements becomes so great that, despite the small cross section, substantial nuclear transmutation is induced. Neutrinos excite heavy elements and even helium to particle unbound levels. The evaporation of a single neutron or proton, and the back reaction of these nucleons on other species present, significantly alters the outcome of traditional nucleosynthesis calculations leading to a new process: nu-nucleosynthesis. Modifications to traditional hydrostatic and explosive varieties of helium, carbon, neon, oxygen, and silicon burning are considered. The results show that a large number of rare isotopes, including many of the odd-Z nuclei from boron through copper, owe much of their present abundance in nature to this process.

Interpretation of quantum yields exceeding unity in photoelectrochemical systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szklarczyk, M.; Allen, R.E.

1986-10-20

In photoelectrochemical systems involving light shining on a semiconductor interfaced with an electrolyte, the quantum yield as a function of photon frequency ..nu.. is observed to exhibit a peak at h..nu..roughly-equal2E/sub g/, where E/sub g/ is the band gap of the semiconductor. The maximum in this peak is sometimes found to exceed unity. We provide an interpretation involving surface states and inelastic electron-electron scattering. The theory indicates that the effect should be observable for p-type semiconductors, but not n-type.

Direct spectral evidence of single-axis rotation and ortho-hydrogen-assisted nuclear spin conversion of CH3F in solid para-hydrogen.

PubMed

Lee, Yuan-Pern; Wu, Yu-Jong; Hougen, Jon T

2008-09-14

Observation of two weak absorption lines from the E (K = 1) level and one intense feature from A (K = 0) for degenerate modes nu(4) and nu(6) of CH(3)F provides direct spectral evidence that CH(3)F isolated in p-H(2) rotates about only its symmetry axis, and not about the other two axes. An interaction between A and E vibrational levels caused by the partially hindered spinning rotation is proposed. Conversion of nuclear spin between A and E components of CH(3)F is rapid when p-H(2) contains some o-H(2), but becomes slow when the proportion of o-H(2) is much decreased.

NuGO contributions to GenePattern

PubMed Central

Reiff, C.; Mayer, C.; Müller, M.

2008-01-01

NuGO, the European Nutrigenomics Organization, utilizes 31 powerful computers for, e.g., data storage and analysis. These so-called black boxes (NBXses) are located at the sites of different partners. NuGO decided to use GenePattern as the preferred genomic analysis tool on each NBX. To handle the custom made Affymetrix NuGO arrays, new NuGO modules are added to GenePattern. These NuGO modules execute the latest Bioconductor version ensuring up-to-date annotations and access to the latest scientific developments. The following GenePattern modules are provided by NuGO: NuGOArrayQualityAnalysis for comprehensive quality control, NuGOExpressionFileCreator for import and normalization of data, LimmaAnalysis for identification of differentially expressed genes, TopGoAnalysis for calculation of GO enrichment, and GetResultForGo for retrieval of information on genes associated with specific GO terms. All together, these NuGO modules allow comprehensive, up-to-date, and user friendly analysis of Affymetrix data. A special feature of the NuGO modules is that for analysis they allow the use of either the standard Affymetrix or the MBNI custom CDF-files, which remap probes based on current knowledge. In both cases a .chip-file is created to enable GSEA analysis. The NuGO GenePattern installations are distributed as binary Ubuntu (.deb) packages via the NuGO repository. PMID:19034553

NuGO contributions to GenePattern.

PubMed

De Groot, P J; Reiff, C; Mayer, C; Müller, M

2008-12-01

NuGO, the European Nutrigenomics Organization, utilizes 31 powerful computers for, e.g., data storage and analysis. These so-called black boxes (NBXses) are located at the sites of different partners. NuGO decided to use GenePattern as the preferred genomic analysis tool on each NBX. To handle the custom made Affymetrix NuGO arrays, new NuGO modules are added to GenePattern. These NuGO modules execute the latest Bioconductor version ensuring up-to-date annotations and access to the latest scientific developments. The following GenePattern modules are provided by NuGO: NuGOArrayQualityAnalysis for comprehensive quality control, NuGOExpressionFileCreator for import and normalization of data, LimmaAnalysis for identification of differentially expressed genes, TopGoAnalysis for calculation of GO enrichment, and GetResultForGo for retrieval of information on genes associated with specific GO terms. All together, these NuGO modules allow comprehensive, up-to-date, and user friendly analysis of Affymetrix data. A special feature of the NuGO modules is that for analysis they allow the use of either the standard Affymetrix or the MBNI custom CDF-files, which remap probes based on current knowledge. In both cases a .chip-file is created to enable GSEA analysis. The NuGO GenePattern installations are distributed as binary Ubuntu (.deb) packages via the NuGO repository.

Effect of Muslim prayer (Salat) on α electroencephalography and its relationship with autonomic nervous system activity.

PubMed

Doufesh, Hazem; Ibrahim, Fatimah; Ismail, Noor Azina; Wan Ahmad, Wan Azman

2014-07-01

This study investigated the effect of Muslim prayer (salat) on the α relative power (RPα) of electroencephalography (EEG) and autonomic nervous activity and the relationship between them by using spectral analysis of EEG and heart rate variability (HRV). Thirty healthy Muslim men participated in the study. Their electrocardiograms and EEGs were continuously recorded before, during, and after salat practice with a computer-based data acquisition system (MP150, BIOPAC Systems Inc., Camino Goleta, California). Power spectral analysis was conducted to extract the RPα and HRV components. During salat, a significant increase (p<.05) was observed in the mean RPα in the occipital and parietal regions and in the normalized unit of high-frequency (nuHF) power of HRV (as a parasympathetic index). Meanwhile, the normalized unit of low-frequency (nuLF) power and LF/HF of HRV (as sympathetic indices) decreased according to HRV analyses. RPα showed a significant positive correlation in the occipital and parietal electrodes with nuHF and significant negative correlations with nuLF and LF/HF. During salat, parasympathetic activity increased and sympathetic activity decreased. Therefore, regular salat practices may help promote relaxation, minimize anxiety, and reduce cardiovascular risk.

Study of the decays D0-->pi{-}e{+}nu{e}, D{0}-->K{-}e{+}nu{e}, D{+}-->pi{0}e{+}nu{e}, and D{+}-->K0e{+}nu{e}.

PubMed

Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Severini, H; Dytman, S A; Love, W; Savinov, V; Aquines, O; Li, Z; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Brock, I; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; Athar, S B; Patel, R; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Wiss, J; Shepherd, M R; Besson, D; Pedlar, T K

2008-06-27

By using 1.8x10{6} DDpairs, we have measured B(D{0}-->pi{-}e{+}nu{e})=0.299(11)(9)%, B(D{+}-->pi{0}e{+}nu{e})=0.373(22)(13)%, B(D{0}-->K{-}e{+}nu{e})=3.56(3)(9)%, and B(D{+}-->K{0}e{+}nu{e})=8.53(13)(23)% and have studied the q;{2} dependence of the form factors. By combining our results with recent lattice calculations, we obtain |V{cd}|=0.217(9)(4)(23) and |V{cs}|=1.015(10)(11)(106).

Status of the OPERA experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russo, A.

2011-11-23

The OPERA experiment in the underground Gran Sasso Laboratory (LNGS) has been designed to perform the first detection of neutrino oscillations in direct appearance mode in the muon to tau neutrino channel. The detector is hybrid, being made of an emulsion/lead target and of electronic detectors. It is placed in the CNGS neutrino beam 733 km away from the neutrino source. Runs with CNGS neutrinos were successfully carried out from 2008 and the following years. The analysis of a sample of events corresponding to 1.89x10{sup 19} p.o.t. in the CERN CNGS {nu}{sub {mu}} beam yielded the observation of a firstmore » candidate {nu}{sub {tau}} CC interaction. The topology and kinematics of this candidate event is described in detail. The background sources are explained and the significance of the observation of the first {nu}{sub {tau}} event candidate is assessed.« less

KSC-2012-3525

NASA Image and Video Library

2012-06-13

KWAJALEIN ATOLL, Marshall Islands - Orbital Sciences' L-1011 "Stargazer" aircraft takes off from the runway at Kwajalein Atoll with the company's Pegasus rocket to launch NASA's Nuclear Spectroscopic Telescope Array, or NuSTAR, payload strapped to the belly of the plane. The plane left Kwajalein one hour before launch. At 9:00:35 a.m. PDT 12:00:35 p.m. EDT), June 13, 2012, the rocket dropped with the NuSTAR payload 117 nautical miles south of Kwajalein. NuSTAR will use a unique set of “eyes” to see the highest energy X-ray light from the cosmos to reveal black holes lurking in our Milky Way galaxy, as well as those hidden in the hearts of faraway galaxies. Kwajalein is located in the Marshall Islands chain in the Pacific Ocean and is part of the Reagan Test Site and used for launches of NASA, commercial and military missions. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA

KSC-2012-3524

NASA Image and Video Library

2012-06-13

KWAJALEIN ATOLL, Marshall Islands - Orbital Sciences' L-1011 "Stargazer" aircraft takes off from the runway at Kwajalein Atoll with the company's Pegasus rocket to launch NASA's Nuclear Spectroscopic Telescope Array, or NuSTAR. The plane left Kwajalein one hour before launch. At 9:00:35 a.m. PDT 12:00:35 p.m. EDT), June 13, 2012, the rocket dropped with the NuSTAR payload 117 nautical miles south of Kwajalein. NuSTAR will use a unique set of “eyes” to see the highest energy X-ray light from the cosmos to reveal black holes lurking in our Milky Way galaxy, as well as those hidden in the hearts of faraway galaxies. Kwajalein is located in the Marshall Islands chain in the Pacific Ocean and is part of the Reagan Test Site and used for launches of NASA, commercial and military missions. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA

KSC-2012-3523

NASA Image and Video Library

2012-06-13

KWAJALEIN ATOLL, Marshall Islands - The lights of Orbital Sciences' L-1011 "Stargazer" aircraft illuminates the night sky as it takes off from the runway at Kwajalein Atoll with the company's Pegasus rocket to launch NASA's Nuclear Spectroscopic Telescope Array, or NuSTAR. The plane left Kwajalein one hour before launch. At 9:00:35 a.m. PDT 12:00:35 p.m. EDT), June 13, 2012, the rocket dropped with the NuSTAR payload 117 nautical miles south of Kwajalein. NuSTAR will use a unique set of “eyes” to see the highest energy X-ray light from the cosmos to reveal black holes lurking in our Milky Way galaxy, as well as those hidden in the hearts of faraway galaxies. Kwajalein is located in the Marshall Islands chain in the Pacific Ocean and is part of the Reagan Test Site and used for launches of NASA, commercial and military missions. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA

Forward- and reverse-bias tunneling effects in n/+/p silicon solar cells

NASA Technical Reports Server (NTRS)

Garlick, G. F. J.; Kachare, A. H.

1980-01-01

Excess currents due to field-assisted tunneling in both forward and reverse bias directions have been observed in n(+)-p silicon solar cells. These currents arise from the effect of conducting paths produced in the depletion layer by n(+) diffusion and cell processing. Forward-bias data indicate a small potential barrier with height of 0.04 eV at the n(+) end of conducting paths. Under reverse bias, excess tunneling currents involve a potential barrier at the p end of the conducting paths, the longer paths being associated with smaller barrier heights and dominating at the lower temperatures. Low-reverse-bias data give energy levels of 0.11 eV for lower temperatures (253-293 K) and 0.35 eV for higher temperatures (293-380 K). A model is suggested to explain the results.

Simple systematization of vibrational excitation cross-section calculations for resonant electron-molecule scattering in the boomerang and impulse models.

PubMed

Sarma, Manabendra; Adhikari, S; Mishra, Manoj K

2007-01-28

Vibrational excitation (nu(f)<--nu(i)) cross-sections sigma(nu(f)<--nu(i) )(E) in resonant e-N(2) and e-H(2) scattering are calculated from transition matrix elements T(nu(f),nu(i) )(E) obtained using Fourier transform of the cross correlation function , where psi(nu(i))(R,t) approximately =e(-iH(A(2))-(R)t/h phi(nu(i))(R) with time evolution under the influence of the resonance anionic Hamiltonian H(A(2) (-))(A(2) (-)=N(2)(-)/H(2) (-)) implemented using Lanczos and fast Fourier transforms. The target (A(2)) vibrational eigenfunctions phi(nu(i))(R) and phi(nu(f))(R) are calculated using Fourier grid Hamiltonian method applied to potential energy (PE) curves of the neutral target. Application of this simple systematization to calculate vibrational structure in e-N(2) and e-H(2) scattering cross-sections provides mechanistic insights into features underlying presence/absence of structure in e-N(2) and e-H(2) scattering cross-sections. The results obtained with approximate PE curves are in reasonable agreement with experimental/calculated cross-section profiles, and cross correlation functions provide a simple demarcation between the boomerang and impulse models.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seo, Jae Sung; Kim, Ha Na; Kim, Sun-Jick

Highlights: •NuMA is modified by SUMO-1 in a cell cycle-dependent manner. •NuMA lysine 1766 is the primary target site for SUMOylation. •SUMOylation-deficient NuMA induces multiple spindle poles during mitosis. •SUMOylated NuMA induces microtubule bundling. -- Abstract: Covalent conjugation of proteins with small ubiquitin-like modifier 1 (SUMO-1) plays a critical role in a variety of cellular functions including cell cycle control, replication, and transcriptional regulation. Nuclear mitotic apparatus protein (NuMA) localizes to spindle poles during mitosis, and is an essential component in the formation and maintenance of mitotic spindle poles. Here we show that NuMA is a target for covalent conjugationmore » to SUMO-1. We find that the lysine 1766 residue is the primary NuMA acceptor site for SUMO-1 conjugation. Interestingly, SUMO modification of endogenous NuMA occurs at the entry into mitosis and this modification is reversed after exiting from mitosis. Knockdown of Ubc9 or forced expression of SENP1 results in impairment of the localization of NuMA to mitotic spindle poles during mitosis. The SUMOylation-deficient NuMA mutant is defective in microtubule bundling, and multiple spindles are induced during mitosis. The mitosis-dependent dynamic SUMO-1 modification of NuMA might contribute to NuMA-mediated formation and maintenance of mitotic spindle poles during mitosis.« less

Identification and characterization of novel NuMA isoforms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Jin, E-mail: petersdu2112@hotmail.com; Xu, Zhe; Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing

2014-11-21

Highlights: • Seven NuMA isoforms generated by alternative splicing were categorized into 3 groups: long, middle and short. • Both exons 15 and 16 in long NuMA were “hotspot” for alternative splicing. • Lower expression of short NuMA was observed in cancer cells compared with nonneoplastic controls. • Distinct localization pattern of short isoforms indicated different function from that of long and middle NuMA. - Abstract: The large nuclear mitotic apparatus (NuMA) has been investigated for over 30 years with functions related to the formation and maintenance of mitotic spindle poles during mitosis. However, the existence and functions of NuMAmore » isoforms generated by alternative splicing remains unclear. In the present work, we show that at least seven NuMA isoforms (categorized into long, middle and short groups) generated by alternative splicing from a common NuMA mRNA precursor were discovered in HeLa cells and these isoforms differ mainly at the carboxyl terminus and the coiled-coil domains. Two “hotspot” exons with molecular mass of 3366-nt and 42-nt tend to be spliced during alternative splicing in long and middle groups. Furthermore, full-length coding sequences of long and middle NuMA obtained by using fusion PCR were constructed into GFP-tagged vector to illustrate their cellular localization. Long NuMA mainly localized in the nucleus with absence from nucleoli during interphase and translocated to the spindle poles in mitosis. Middle NuMA displayed the similar cell cycle-dependent distribution pattern as long NuMA. However, expression of NuMA short isoforms revealed a distinct subcellular localization. Short NuMA were present in the cytosol during the whole cycle, without colocalization with mitotic apparatus. These results have allowed us tentatively to explore a new research direction for NuMA’s various functions.« less

Depression is associated with increased vagal withdrawal during unpleasant emotional imagery after cardiac surgery.

PubMed

Patron, Elisabetta; Messerotti Benvenuti, Simone; Favretto, Giuseppe; Gasparotto, Renata; Palomba, Daniela

2015-05-01

The aim of this study was to examine the influence of depression on heart rate and heart rate variability (HRV) during emotional imagery in patients after cardiac surgery. Based on the scores of the Center for Epidemiological Studies of Depression (CES-D) scale, 28 patients after cardiac surgery were assigned either to the group with depression (CES-D scores ≥ 16; N = 14) or the one without depression (CES-D scores<16; N = 14). Each patient completed a rest period and an emotional imagery including pleasant, neutral and unpleasant scripts. Inter-beat intervals (IBIs) and HRV were measured during the entire protocol. Compared to nondepressed patients, those with depression had greater reductions in high frequency expressed in normalized units (HF n.u.) during the imaging of the unpleasant script (p = .003, Cohen's d = 1.34). Moreover, HF n.u. were lower during the imaging of the unpleasant script than the pleasant one in depressed patients only (p = .020, Cohen's d = 0.55). CES-D scores were also inversely correlated with residualized changes in IBIs (r = -.38, p = .045) and HF n.u. (r = -.49, p = .008) from rest to the imaging of the unpleasant script. The relationship between depression and increased vagal withdrawal during unpleasant emotional imagery extends to patients after cardiac surgery. The present study suggests that increased vagal withdrawal to negative emotions in patients after cardiac surgery may mediate the conferral of cardiac risk by depression. Copyright © 2014 Elsevier B.V. All rights reserved.

Q-Switched Raman laser system

DOEpatents

George, E. Victor

1985-01-01

Method and apparatus for use of a Raman or Brillouin switch together with a conventional laser and a saturable absorber that is rapidly bleached at a predetermined frequency .nu.=.nu..sub.0, to ultimately produce a Raman or Brillouin pulse at frequency .nu.=.nu..sub.0 .+-..nu..sub.Stokes.

Q-switched Raman laser system

DOEpatents

George, E.V.

Method and apparatus for use of a Raman or Brillouin switch together with a conventional laser and a saturable absorber that is rapidly bleached at a predeterimined frequency nu = nu/sub O/, to ultimately produce a Raman or Brillouin pulse at frequency nu = nu/sub O/ +- nu /sub Stokes/.

Root canal anatomy preservation of WaveOne reciprocating files with or without glide path.

PubMed

Berutti, Elio; Paolino, Davide Salvatore; Chiandussi, Giorgio; Alovisi, Mario; Cantatore, Giuseppe; Castellucci, Arnaldo; Pasqualini, Damiano

2012-01-01

This study evaluated the influence of glide path on canal curvature and axis modification after instrumentation with WaveOne Primary reciprocating files. Thirty ISO 15, 0.02 taper Endo Training Blocks were used. In group 1, glide path was created with PathFile 1, 2, and 3 at working length, whereas in group 2, glide path was not performed. In both groups, canals were shaped with WaveOne Primary reciprocating files at working length. Preinstrumentation and postinstrumentation digital images were superimposed and processed with Matlab r2010b software to analyze the curvature radius ratio (CRr) and the relative axis error (rAe), representing canal curvature modification. Data were analyzed with 1-way balanced analyses of variance at 2 levels (P < .05). Glide path was found to be extremely significant for both CRr parameter (F = 9.59; df = 1; P = .004) and rAe parameter (F = 13.55; df = 1; P = .001). Canal modifications seem to be significantly reduced when previous glide path is performed by using the new WaveOne nickel-titanium single-file system. Copyright © 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Determination of the Michel Parameters and the tau Neutrino Helicity in tau Decay

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jessop, Colin P.

2003-05-07

Using the CLEO II detector at the e{sup +}e{sup -} storage ring CESR, we have determined the Michel parameters {rho}, {zeta}, and {delta} in {tau}{sup {-+}}{nu}{bar {nu}} decay as well as the {tau} neutrino helicity parameter H{sub {nu}{sub {tau}}} in {tau}{sup {-+}}{pi}{sup 0}{nu} decay. From a data sample of 3.02 x 10{sup 6} {tau} pairs produced at {radical}s = 10.6 GeV, using events of the topology e{sup +}e{sup -} {yields} {tau}{sup +}{tau}{sup -} {yields} (l{sup {+-}}{nu}{bar {nu}})({pi}{sup {-+}}{pi}{sup 0}{nu}) and e{sup +}e{sup -} {yields} {tau}{sup +}{tau}{sup -} {yields} ({pi}{sup {+-}}{pi}{sup 0}{bar {nu}})({pi}{sup {-+}}{pi}{sup 0}{nu}), and the determined sign of h{submore » {nu}{sub {tau}}} [1,2], the combined result of the three samples is: {rho} = 0.747 {+-} 0.010 {+-} 0.006, {zeta} = 1.007 {+-} 0.040 {+-} 0.015, {zeta}{delta} = 0.745 {+-}0.026 {+-}0.009, and h{sub {nu}{sub {tau}}} = -0.995 {+-} 0.010 {+-} 0.003. The results are in agreement with the Standard Model V-A interaction.« less

Study of. nu. d r arrow. mu. sup minus pp sub s and. nu. d r arrow. mu. sup minus. Delta. sup ++ (1232) n sub s using the BNL 7-foot deuterium-filled bubble chamber

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kitagaki, T.; Yuta, H.; Tanaka, S.

1990-09-01

The weak nucleon axial-vector ({ital F}{sub {ital A}}) and vector ({ital F}{sub {ital V}}) form factors are determined from the momentum-transfer-squared ({ital Q}{sup 2}) distributions using 2538 {mu}{sup {minus}} {ital p} and 1384 {mu}{sup {minus}}{Delta}{sup ++} events. The data were obtained from 1 800 000 pictures taken in the BNL 7-foot deuterium-filled bubble chamber exposed to a wide-band neutrino beam with a mean energy {ital E}{sub {nu}}=1.6 GeV. In the framework of the conventional {ital V}{minus}{ital A} theory with standard assumptions, the value obtained from the {mu}{sup {minus}}{ital p} events for the axial-vector mass {ital M}{sub {ital A}} in themore » pure dipole parameterization is 1.070{sub {minus}0.045}{sup +0.040} GeV and from the {mu}{sup {minus}}{Delta}{sup ++} events is 1.28{sub {minus}0.10}{sup +0.08} GeV. These results are in good agreement with an earlier measurement from this experiment and other recent results. The reaction mechanisms for both processes are compared and found to be very similar. A two-parameter fit for the quasielastic reaction, using dipole forms for {ital F}{sub {ital V}} and {ital F}{sub {ital A}}, yields {ital M}{sub {ital A}}=0.97{sub {minus}0.11}{sup +0.14} GeV and {ital M}{sub {ital V}}=0.89{sub {minus}0.07}{sup +0.04} GeV, which is in good agreement with the conserved-vector-current value of {ital M}{sub {ital V}}=0.84 GeV. Possible deviations from the standard assumptions are also discussed.« less

Matrix isolation infrared spectra of hydrogen halide and halogen complexes with nitrosyl halides

NASA Technical Reports Server (NTRS)

Allamandola, Louis J.; Lucas, Donald; Pimentel, George C.

1982-01-01

Matrix isolation infrared spectra of nitrosyl halide (XNO) complexes with HX and X2 (X = Cl, Br) are presented. The relative frequency shifts of the HX mode are modest (ClNO H-Cl, delta-nu/nu = -0.045; BrNO H-Br, delta-nu/nu = -0.026), indicating weak hydrogen bonds 1-3 kcal/mol. These shifts are accompanied by significant shifts to higher frequencies in the XN-O stretching mode (CIN-O HCl, delta-nu/nu = +0.016; BrN-O HBr, delta-nu/nu = +0.011). Similar shifts were observed for the XN-O X2 complexes (ClN-O Cl2, delta-nu/nu = +0.009; BrN-O-Br2, delta-nu/nu = +0.013). In all four complexes, the X-NO stretching mode relative shift is opposite in sign and about 1.6 times that of the NO stretching mode. These four complexes are considered to be similar in structure and charge distribution. The XN-O frequency shift suggests that complex formation is accompanied by charge withdrawal from the NO bond ranging from about .04 to .07 electron charges. The HX and X2 molecules act as electron acceptors, drawing electrons out of the antibonding orbital of NO and strengthening the XN-O bond. The implications of the pattern of vibrational shifts concerning the structure of the complexes are discussed.

a Search for Neutrino-Electron Elastic Scattering at the LAMPF Beam Stop.

NASA Astrophysics Data System (ADS)

Brooks, George Alfred

Neutrino-electron elastic scattering reactions play an important role in tests of weak interaction theory. The four reactions which may be considered are:. (nu)(,e) + e('-) (--->) (nu)(,e) + e('-). (nu)(,e)(' )+ e('-) (--->) (nu)(,e) + e('-). (nu)(,(mu)) + e('-) (--->) (nu)(,(mu)) + e('-). (nu)(,(mu))(' )+ e('-) (--->) (nu)(,(mu)) + e(' -). The experimental study of these purely leptonic interactions severely tests basic theoretical ideas, and the reaction with (nu)(,e) has not yet been observed. The characteristics of Los Alamos Meson Physics Facility. (LAMPF) are such that (nu)(,e) is rarely produced, whereas (nu)(,e),(nu)(,(mu)), and(' ). (nu)(,(mu)) are present in equal numbers. Thus, data on all three processes(' ). will be collected simultaneously, but the (nu)(,e) reaction is expected to dominate. However, such studies are exceedingly difficult. The main problem arises from the nature of the event signature (an undetected particle enters the detector producing a single recoil electron) coupled with the miniscule cross sections expected (and therefore low event rates) amid numerous sources of background events. To learn how to reduce the rates of such backgrounds, the UCI Neutrino Group installed in the Neutrino Facility in 1974 a small scale detector system consisting of a sandwich of optical spark chambers and plastic scintillator slabs (0.38 metric tons) which was shielded by 2 1/2" of Pb and enclosed by tanks of liquid scintillator used as an anticoincidence. Electronics and instrumentation, including a CAMAC system interfaced with a PDP-11/05 computer, were housed in a nearby trailer. The 1974 study was carried out with the LAMPF Neutrino Facility shielded against cosmic rays by Fe walls 3' thick and a 4' Fe roof. Nevertheless, stopping cosmic ray muons appeared to give rise to the substantial number of background electron events observed. Several techniques were invoked to reduce the potential background for neutrino -electron elastic scattering to (1.5 (+OR-) 0.5) day('-1). Improved statistics from 1976 gave (1.48 (+OR-) 0.34) day('-1). If this number could be further reduced--by additional shielding, for example--then the experiment would be easier. However, data taken in 1975 with varying thicknesses of Pb on top of the sandwich detector and in 1976 with an additional 1' of Fe on the roof showed that there is no significant advantage to having more Pb or Fe in those areas. The accelerator may also be a source of background. When the accelerator is operating, neutrons from the beam stop can penetrate the Fe shielding to produce an excessive trigger rate (energetic neutrons) or on excessive dead time (thermal neutrons), especially in the more massive ANTI required for the full scale experiment. However, data taken in 1974 with 10(mu)A accelerator current and 4m Fe as beam stop shielding, and in 1976 with 100 (mu)A and 5m Fe, showed that the neutron flux was well under control. The ultimate configuration requires much higher beam currents, but also calls for additional Fe so that neutrons will not be a problem. In both 1974 and 1976 there were no electron events remaining in the accelerator data following subtraction of cosmic ray background. This fact can be used to set an upper limit on the elastic scattering cross section for (nu)(,e):. (sigma)(,exp) < 38 (sigma)(,V-A) with 90% confidence. The results of these studies determined the amount of shielding required for a full scale neutrino experiment, established the need for a very efficient active anticoincidence, and aided the design of a 14.4 metric ton sandwich detector of flash chamber modules and plastic scintillator slabs. Developmental work for the full scale detector system began in 1977, and some of the subsequent construction work is still in progress. However, the Neutrino Facility has been prepared, and portions of the sandwich detector have been installed. The first information on neutrino -electron elastic scattering could be available by the middle of 1982.

Off-great-circle paths in transequatorial propagation: 2. Nonmagnetic-field-aligned reflections

NASA Astrophysics Data System (ADS)

Tsunoda, Roland T.; Maruyama, Takashi; Tsugawa, Takuya; Yokoyama, Tatsuhiro; Ishii, Mamoru; Nguyen, Trang T.; Ogawa, Tadahiko; Nishioka, Michi

2016-11-01

There is considerable evidence that plasma structure in nighttime equatorial F layer develops from large-scale wave structure (LSWS) in bottomside F layer. However, crucial details of how this process proceeds, from LSWS to equatorial plasma bubbles (EPBs), remain to be sorted out. A major obstacle to success is the paucity of measurements that provide a space-time description of the bottomside F layer over a broad geographical region. The transequatorial propagation (TEP) experiment is one of few methods that can do so. New findings using a TEP experiment, between Shepparton (SHP), Australia, and Oarai (ORI), Japan, are presented in two companion papers. In Paper 1 (P1), (1) off-great-circle (OGC) paths are described in terms of discrete and diffuse types, (2) descriptions of OGC paths are generalized from a single-reflection to a multiple-reflection process, and (3) discrete type is shown to be associated with an unstructured but distorted upwelling, whereas the diffuse type is shown to be associated with EPBs. In Paper 2 (P2), attention is placed on differences in east-west (EW) asymmetry, found between OGC paths from the SHP-ORI experiment and those from another near-identical TEP experiment. Differences are reconciled by allowing three distinct sources for the EW asymmetries: (1) reflection properties within an upwelling (see P1), (2) OGC paths that depend on magnetic declination of geomagnetic field (B), and (3) OGC paths supported by non-B-aligned reflectors at latitudes where inclination of B is finite.

A comment on Baxter condition for commutativity of transfer matrices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gutkin, E.

1986-07-01

Let T..nu.. and T'..nu.. be the transfer matrices of two vertex models corresponding to two sets of Boltzmann weights. The Baxter condition on Boltzmann weights was known to be sufficient for commutativity of T..nu.. and T'..nu.. for all ..nu... We show that generically it is also necessary.

PREFACE: XIII International Workshop on Neutrino Factories, Super beams and Beta beams (NUFACT11)

NASA Astrophysics Data System (ADS)

Blondel, Alain; Efthymiopoulos, Ilias; Prior, Gersende

2013-02-01

These proceedings present the written contributions from participants of the International Workshop on Neutrino Factories, Superbeams and Betabeams (NuFact11), which was held in Geneva, Switzerland, on 1-6 August 2011. This was the 13th of the series of NuFact annual meetings, which started in 1999. The six-day scientific programme of NuFact11 consisted of 42 plenary and 111 parallel talks and various poster sessions, with the participation of 191 researchers from 19 countries. In addition the International Neutrino Summer School 2011 was held in the two weeks preceding the workshop. It was intended for young scientists starting their research in neutrino physics in such a way that they would be able to participate and contribute to the workshop. The objective of the NuFact workshops is to build up, time after time, the scientific knowledge on accelerator facilities aimed at the study of neutrino oscillation. The organization of the workshop is tailored to ensure continuity and growth of knowledge: working group conveners have a mandate of three consecutive meetings and maintain an updated list of questions. In order to emphasize further the 'work' (by opposition to 'shop') part of the meeting, we organized a 'round table discussion' at the beginning of the workshop, in which the invitees were asked not only to provide their answers to a preset list of questions, but to propose their own questions to the participants. This was quite successful and we have compiled the answers in this book. Topics addressed at NuFact included neutrino oscillation physics, neutrino cross-sections and detectors, accelerator physics, muon physics and high-intensity applications of muons beams. This variety of subjects is reflected in these proceedings. The editors hope to provide more than enjoyable and fruitful reading for those interested in neutrino physics, a stepping stone along the path to always more insightful research on these mysterious neutrinos, which certainly contain the solution to several essential questions. It is a pleasure to thank CERN, University of Geneva, the Swiss Institute for Particle Physics (CHIPP) and the European FP7 mandate EuCARD that sponsored the meeting and the Summer School. The Editors wish to thank the Scientific Program Committee and the Working group conveners for their engagement in making NUFACT11 a success, and all participants for the high quality of their contributions. The Local organizing committee members worked beyond the call of duty to ensure a great and lively working atmosphere during the meeting. The Editors: Alain Blondel, Ilias Efthymiopoulos and Gersende Prior

The Nuclear Spectroscopic Telescope Array (NuSTAR)

NASA Technical Reports Server (NTRS)

Harrison, Fiona A.; Boggs, Steven; Christensen, Finn; Craig, William; Hailey, Charles; Stern, Daniel; Zhang, William; Angelini, Lorella; An, Hong Jun; Bhalereo, Varun;

"I wanted to do a good job": experiences of 'becoming a mother' and breastfeeding in mothers of very preterm infants after discharge from a neonatal unit.

PubMed

Flacking, Renée; Ewald, Uwe; Starrin, Bengt

2007-06-01

In mothers of preterm infants, the process of becoming a mother is initiated in a public and medical environment, in which the mothers become dependent on the benevolence and support of the staff. This setting and an experience of insecure social bonds impair the ability to become a mother during the infant's stay at the neonatal unit (NU), and breastfeeding may become a duty and not be mutually satisfying. Studies on how women experience becoming a mother and breastfeeding after the infant's discharge are sparse and this question is addressed in the present grounded theory study. Twenty five mothers, whose very preterm infants had received care in seven NUs in Sweden, were interviewed once, 1-12 months after discharge. We propose a model to increase understanding of the process of becoming a mother and breastfeeding, after the infant's discharge from the NU. The mother's emotional expressions in this process showed pendular swings from feeling emotionally exhausted to feeling relieved, from experiencing an insecure to a secure bond, and from regarding breastfeeding as being non-reciprocal to being reciprocal. Unresolved grief, the institutional authority at the NU and experiences of shame were three of the central barriers to a secure and reciprocal relationship. The pendular changes give us a deeper understanding of the variations in both attachment and attunement. Perhaps the negative extremes are more prominent among these mothers on account of their infant's illness and their NU experiences. If our proposed model is valid, it is vital that these findings are considered by those involved in the short- and long-term care in order to support the mothers to establish a secure bond, comprising both attachment and attunement.

Enzymatic degradation of hybrid iota-/nu-carrageenan by Alteromonas fortis iota-carrageenase.

PubMed

Jouanneau, Diane; Boulenguer, Patrick; Mazoyer, Jacques; Helbert, William

2010-05-07

Hybrid iota-/nu-carrageenan was water-extracted from Eucheuma denticulatum and incubated with Alteromonas fortis iota-carrageenase. The degradation products were then separated by anion-exchange chromatography. The three most abundant fractions of hybrid iota-/nu-carrageenan oligosaccharides were purified and their structures were analyzed by NMR. The smallest hybrid was an octasaccharide with a iota-iota-nu-iota structure. The second fraction was composed of two decasaccharides with iota-iota-iota-nu-iota and iota-[iota/nu]-iota-iota structures. The third fraction was a mixture of dodecasaccharides which contained at least a iota-iota-iota-iota-nu-iota oligosaccharide. The carbon and proton NMR spectra of the octasaccharides were completely assigned, thereby completely attributing the nu-carrabiose moiety for the first time.

Measurement of the absolute branching fraction of Ds+ --> tau+ nutau decay.

PubMed

Ecklund, K M; Love, W; Savinov, V; Lopez, A; Mendez, H; Ramirez, J; Ge, J Y; Miller, D H; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Artuso, M; Blusk, S; Khalil, S; Li, J; Mountain, R; Nisar, S; Randrianarivony, K; Sultana, N; Skwarnicki, T; Stone, S; Wang, J C; Zhang, L M; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Rademacker, J; Asner, D M; Edwards, K W; Naik, P; Reed, J; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P; Eisenstein, B I; Karliner, I; Mehrabyan, S; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Libby, J; Powell, A; Wilkinson, G

2008-04-25

Using a sample of tagged D(s)(+) decays collected near the D(s)(*+/-)D(s)(-/+) peak production energy in e(+)e(-) collisions with the CLEO-c detector, we study the leptonic decay D(s)(+)-->tau(+)nu(tau) via the decay channel tau(+)-->e(+)nu(e)nu(tau). We measure B(D(s)(+)-->tau(+)nu(tau))=(6.17+/-0.71+/-0.34)%, where the first error is statistical and the second systematic. Combining this result with our measurements of D(s)(+)-->mu(+)nu(mu) and D(s)(+)-->tau(+)nu(tau) (via tau(+)-->pi(+)nu(tau)), we determine f(D(s))=(274+/-10+/-5) MeV.

Mutants in the Mouse NuRD/Mi2 Component P66α Are Embryonic Lethal

PubMed Central

Marino, Susan; Nusse, Roel

2007-01-01

Background The NuRD/Mi2 chromatin complex is involved in histone modifications and contains a large number of subunits, including the p66 protein. There are two mouse and human p66 paralogs, p66α and p66β. The functions of these genes are not clear, in part because there are no mutants available, except in invertebrate model systems. Methodology We made loss of function mutants in the mouse p66α gene (mp66α, official name Gatad2a, MGI:2384585). We found that mp66α is essential for development, as mutant embryos die around day 10 of embryogenesis. The gene is not required for normal blastocyst development or for implantation. The phenotype of mutant embryos and the pattern of gene expression in mutants are consistent with a role of mp66α in gene silencing. Conclusion mp66α is an essential gene, required for early mouse development. The lethal phenotype supports a role in execution of methylated DNA silencing. PMID:17565372

Wavelength-resolved emission spectroscopy of the alkoxy and alkylthio radicals in a supersonic jet

NASA Technical Reports Server (NTRS)

Misra, Prabhakar; Zhu, Xinming; Hsueh, Ching-Yu; Kamal, Mohammed M.

1993-01-01

Wavelength-resolved emission spectra of methoxy (CH3O) and methylthio (CH3S) radicals have been obtained in a supersonic jet environment with a resolution of 0.3 nm by dispersing the total laser-induced fluorescence with a 0.6 m monochromator. A detailed analysis of the single vibronic level dispersed fluorescence spectra yields the following vibrational frequencies for CH3O in the X(2)E state; nu(sub 1 double prime) = 2953/cm, nu(sub 2 double prime) = 1375/cm, nu(sub 3 double prime) = 1062/cm, nu(sub 4 double prime) = 2869/cm, nu(sub 5 double prime) = 1528/cm and nu(sub 6 double prime) = 688/cm. A similar analysis of the wavelength-resolved emission spectra of CH3S provides the following ground state vibrational frequencies: nu(sub 2 double prime) = 1329/cm, nu(sub 3 double prime) = 739/cm and nu(sub 6 double prime) = 601/cm. An experimental uncertainty of 20/cm is estimated for the assigned frequencies.

NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force

PubMed Central

Li, Chenyu; Xue, Chenyi; Yang, Qiaoyun; Low, Boon Chuan; Liou, Yih-Cherng

2016-01-01

In vertebrate cells, chromosomes oscillate to align precisely during metaphase. NuSAP, a microtubule-associated protein, plays a critical role in stabilizing spindle microtubules. In this study, we utilize 3D time-lapse live-cell imaging to monitor the role of NuSAP in chromosome oscillation and identify NuSAP as a novel regulator of the chromokinesin, Kid. Depletion of NuSAP significantly suppresses the amplitude and velocity of chromosome oscillation. We analyse the effects of NuSAP and Kid depletion in monopolar and bipolar cells with or without kinetochore microtubule depletion. Twelve postulated conditions are deciphered to reveal the contribution of NuSAP to the polar force generated at kinetochore microtubules and to the regulation of the polar ejection force generated by Kid, thus revealing a pivotal role of NuSAP in chromosome oscillation. PMID:26839278

NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force.

PubMed

Li, Chenyu; Xue, Chenyi; Yang, Qiaoyun; Low, Boon Chuan; Liou, Yih-Cherng

2016-02-03

In vertebrate cells, chromosomes oscillate to align precisely during metaphase. NuSAP, a microtubule-associated protein, plays a critical role in stabilizing spindle microtubules. In this study, we utilize 3D time-lapse live-cell imaging to monitor the role of NuSAP in chromosome oscillation and identify NuSAP as a novel regulator of the chromokinesin, Kid. Depletion of NuSAP significantly suppresses the amplitude and velocity of chromosome oscillation. We analyse the effects of NuSAP and Kid depletion in monopolar and bipolar cells with or without kinetochore microtubule depletion. Twelve postulated conditions are deciphered to reveal the contribution of NuSAP to the polar force generated at kinetochore microtubules and to the regulation of the polar ejection force generated by Kid, thus revealing a pivotal role of NuSAP in chromosome oscillation.

Measurement of the branching fractions of exclusive _B-->D(*)(pi)l-_nu l decays in events with a fully reconstructed B meson.

PubMed

Aubert, B; Bona, M; Karyotakis, Y; Lees, J P; Poireau, V; Prudent, X; Tisserand, V; Zghiche, A; Garra Tico, J; Grauges, E; Lopez, L; Palano, A; Pappagallo, M; Eigen, G; Stugu, B; Sun, L; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Osipenkov, I L; Ronan, M T; Tackmann, K; Tanabe, T; Wenzel, W A; del Amo Sanchez, P; Hawkes, C M; Soni, N; Watson, A T; Koch, H; Schroeder, T; Walker, D; Asgeirsson, D J; Cuhadar-Donszelmann, T; Fulsom, B G; Hearty, C; Mattison, T S; McKenna, J A; Barrett, M; Khan, A; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Buzykaev, A R; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Martin, E C; Stoker, D P; Abachi, S; Buchanan, C; Gary, J W; Liu, F; Long, O; Shen, B C; Vitug, G M; Yasin, Z; Zhang, L; Paar, H P; Rahatlou, S; Sharma, V; Campagnari, C; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Schalk, T; Schumm, B A; Seiden, A; Wilson, M G; Winstrom, L O; Chen, E; Cheng, C H; Doll, D A; Echenard, B; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Andreassen, R; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Smith, J G; Ulmer, K A; Wagner, S R; Ayad, R; Gabareen, A M; Soffer, A; Toki, W H; Wilson, R J; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Karbach, M; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Klose, V; Kobel, M J; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Thiebaux, Ch; Verderi, M; Clark, P J; Gradl, W; Playfer, S; Robertson, A I; Watson, J E; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Franchini, P; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Santoro, V; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Chaisanguanthum, K S; Morii, M; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Dauncey, P D; Nash, J A; Panduro Vazquez, W; Tibbetts, M; Behera, P K; Chai, X; Charles, M J; Mallik, U; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gao, Y Y; Gritsan, A V; Guo, Z J; Lae, C K; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Béquilleux, J; D'Orazio, A; Davier, M; Firmino da Costa, J; Grosdidier, G; Höcker, A; Lepeltier, V; Le Diberder, F; Lutz, A M; Pruvot, S; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wang, W F; Wormser, G; Lange, D J; Wright, D M; Bingham, I; Burke, J P; Chavez, C A; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Touramanis, C; Bevan, A J; George, K A; Di Lodovico, F; Sacco, R; Sigamani, M; Cowan, G; Flaecher, H U; Hopkins, D A; Paramesvaran, S; Salvatore, F; Wren, A C; Brown, D N; Davis, C L; Alwyn, K E; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; West, T J; Yi, J I; Anderson, J; Chen, C; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Dallapiccola, C; Hertzbach, S S; Li, X; Salvati, E; Saremi, S; Cowan, R; Dujmic, D; Fisher, P H; Koeneke, K; Sciolla, G; Spitznagel, M; Taylor, F; Yamamoto, R K; Zhao, M; McLachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; De Nardo, G; Lista, L; Monorchio, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; Knoepfel, K J; LoSecco, J M; Benelli, G; Corwin, L A; Honscheid, K; Kagan, H; Kass, R; Morris, J P; Rahimi, A M; Regensburger, J J; Sekula, S J; Wong, Q K; Blount, N L; Brau, J; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Castelli, G; Gagliardi, N; Gaz, A; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Ben-Haim, E; Briand, H; Calderini, G; Chauveau, J; David, P; Del Buono, L; Hamon, O; Leruste, Ph; Malclès, J; Ocariz, J; Perez, A; Prendki, J; Gladney, L; Biasini, M; Covarelli, R; Manoni, E; Angelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Morganti, M; Mazur, M A; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Biesiada, J; Lau, Y P; Lopes Pegna, D; Lu, C; Olsen, J; Smith, A J S; Telnov, A V; Baracchini, E; Cavoto, G; del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, P D; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Renga, F; Voena, C; Ebert, M; Hartmann, T; Schröder, H; Waldi, R; Adye, T; Franek, B; Olaiya, E O; Roethel, W; Wilson, F F; Emery, S; Escalier, M; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, W; Vasseur, G; Yèche, Ch; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; White, R M; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Benitez, J F; Cenci, R; Coleman, J P; Convery, M R; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Hast, C; Innes, W R; Kaminski, J; Kelsey, M H; Kim, H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Lindquist, B; Luitz, S; Luth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Muller, D R; Neal, H; Nelson, S; O'Grady, C P; Ofte, I; Perazzo, A; Perl, M; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Va'vra, J; Wagner, A P; Weaver, M; Wisniewski, W J; Wittgen, M; Wright, D H; Wulsin, H W; Yarritu, A K; Yi, K; Young, C C; Ziegler, V; Burchat, P R; Edwards, A J; Majewski, S A; Miyashita, T S; Petersen, B A; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Pan, B; Saeed, M A; Zain, S B; Spanier, S M; Wogsland, B J; Eckmann, R; Ritchie, J L; Ruland, A M; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martinez-Vidal, F; Milanes, D A; Oyanguren, A; Albert, J; Banerjee, Sw; Bhuyan, B; Hamano, K; Kowalewski, R; Nugent, I M; Roney, J M; Sobie, R J; Gershon, T J; Harrison, P F; Ilic, J; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Dasu, S; Flood, K T; Hollar, J J; Kutter, P E; Pan, Y; Pierini, M; Prepost, R; Vuosalo, C O; Wu, S L

2008-04-18

We report a measurement of the branching fractions for _B-->D(*)(pi)l- _nu(l) decays based on 341.1 fb(-1) of data collected at the Upsilon(4S) resonance with the BABAR detector at the SLAC PEP-II e+ e- storage rings. Events are tagged by fully reconstructing one of the B mesons in a hadronic decay mode. We obtain B(B- -->D(0)l-_nu(l)=(2.33+/-0.09(stat)+/-0.09(syst)%, B(B- -->D(*0)l-_nu(l)=(5.83+/-0.15(stat) +/-0.30(syst) %, B(_B(0)-->D+l-_nu(l)=(2.21+/-0.11(stat) +/-0.12(syst)%, B(_B(0)-->D(*)l-_nu(l)=(5.49+/-0.16(stat)+/-0.25(syst)%, B(B- -->D+pi-l-_nu(l)=(0.42+/-0.06(stat)+/-0.03(syst)%, B(B- -->D(*)+pi-l-_nu(l)=(0.59+/-0.05(stat)+/-0.04(syst)%, B(_B(0)-->D(0)pi+l-_nu(l)=(0.43+/-0.08(stat)+/-0.03(syst)%, and B(_B(0)-->D(*0)pi+l-_nu(l)=(0.48+/-0.08(stat)+/-0.04(syst)%.

High sensitivity search for nu;e's from the sun and other sources at KamLAND.

PubMed

Eguchi, K; Enomoto, S; Furuno, K; Ikeda, H; Ikeda, K; Inoue, K; Ishihara, K; Iwamoto, T; Kawashima, T; Kishimoto, Y; Koga, M; Koseki, Y; Maeda, T; Mitsui, T; Motoki, M; Nakajima, K; Ogawa, H; Owada, K; Piquemal, F; Shimizu, I; Shirai, J; Suekane, F; Suzuki, A; Tada, K; Tajima, O; Takayama, T; Tamae, K; Watanabe, H; Busenitz, J; Djurcic, Z; McKinny, K; Mei, D-M; Piepke, A; Yakushev, E; Berger, B E; Chan, Y D; Decowski, M P; Dwyer, D A; Freedman, S J; Fu, Y; Fujikawa, B K; Goldman, J; Heeger, K M; Lesko, K T; Luk, K-B; Murayama, H; Nygren, D R; Okada, C E; Poon, A W P; Steiner, H M; Winslow, L A; Horton-Smith, G A; Mauger, C; McKeown, R D; Tipton, B; Vogel, P; Lane, C E; Miletic, T; Gorham, P W; Guillian, G; Learned, J G; Maricic, J; Matsuno, S; Pakvasa, S; Dazeley, S; Hatakeyama, S; Svoboda, R; Dieterle, B D; DiMauro, M; Detwiler, J; Gratta, G; Ishii, K; Tolich, N; Uchida, Y; Batygov, M; Bugg, W; Efremenko, Y; Kamyshkov, Y; Kozlov, A; Nakamura, Y; Gould, C R; Karwowski, H J; Markoff, D M; Messimore, J A; Nakamura, K; Rohm, R M; Tornow, W; Young, A R; Chen, M-J; Wang, Y-F

2004-02-20

Data corresponding to a KamLAND detector exposure of 0.28 kton yr has been used to search for nu;(e)'s in the energy range 8.3

NEMA NU 4-2008 comparison of preclinical PET imaging systems.

PubMed

Goertzen, Andrew L; Bao, Qinan; Bergeron, Mélanie; Blankemeyer, Eric; Blinder, Stephan; Cañadas, Mario; Chatziioannou, Arion F; Dinelle, Katherine; Elhami, Esmat; Jans, Hans-Sonke; Lage, Eduardo; Lecomte, Roger; Sossi, Vesna; Surti, Suleman; Tai, Yuan-Chuan; Vaquero, Juan José; Vicente, Esther; Williams, Darin A; Laforest, Richard

2012-08-01

The National Electrical Manufacturers Association (NEMA) standard NU 4-2008 for performance measurements of small-animal tomographs was recently published. Before this standard, there were no standard testing procedures for preclinical PET systems, and manufacturers could not provide clear specifications similar to those available for clinical systems under NEMA NU 2-1994 and 2-2001. Consequently, performance evaluation papers used methods that were modified ad hoc from the clinical PET NEMA standard, thus making comparisons between systems difficult. We acquired NEMA NU 4-2008 performance data for a collection of commercial animal PET systems manufactured since 2000: microPET P4, microPET R4, microPET Focus 120, microPET Focus 220, Inveon, ClearPET, Mosaic HP, Argus (formerly eXplore Vista), VrPET, LabPET 8, and LabPET 12. The data included spatial resolution, counting-rate performance, scatter fraction, sensitivity, and image quality and were acquired using settings for routine PET. The data showed a steady improvement in system performance for newer systems as compared with first-generation systems, with notable improvements in spatial resolution and sensitivity. Variation in system design makes direct comparisons between systems from different vendors difficult. When considering the results from NEMA testing, one must also consider the suitability of the PET system for the specific imaging task at hand.

Energy Distribution among Reaction Products. III: The Method of Measured Relaxation Applied to H + Cl2

NASA Technical Reports Server (NTRS)

Pacey, P. D.; Polyani, J. C.

1971-01-01

The method of measured relaxation is described for the determination of initial vibrational energy distribution in the products of exothermic reaction. Hydrogen atoms coming from an orifice were diffused into flowing chlorine gas. Measurements were made of the resultant ir chemiluminescence at successive points along the line of flow. The concurrent processes of reaction, diffusion, flow, radiation, and deactivation were analyzed in some detail on a computer. A variety of relaxation models were used in an attempt to place limits on k(nu prime), the rate constant for reaction to form HCl in specified vibrational energy levels: H+Cl2 yields (sup K(nu prime) HCl(sub nu prime) + Cl. The set of k(?) obtained from this work is in satisfactory agreement with those obtained by another experimental method (the method of arrested relaxation described in Parts IV and V of the present series.

[Application of FTIR micro-spectroscopy in the tribology].

PubMed

Hu, Zhi-meng

2002-10-01

The wave number of characteristic absorption peak nu asC-O-C of the polyester formed on the frictional process were determined by Fourier Transform Infrared (FTIR) Micro-spectroscopy, and the wave number displacement of characteristic absorption peak nu asC-O-C was analyzed based on the conversion mass of polyester formed. The internal relations between anti-wear order rule of hydroxyl fatty acids and vibration absorption peak nu asC-O-C of polyester formed by hydroxyl fatty acids was deduced according to these results, and the anti-wear order of hydroxyl fatty acids was reasonably explained, that is 13, 14-di-hydroxydocosanoic acid > 13 (14)-monohydroxydocosanoic acid = 9,10-dihydroxyoctadecanoic acid > 9,10,12-trihydroxyoctadecanoic acid > 9(10)-monohydroxyoctadecanoic acid. A net polyester film is formed by 13, 14-dihydroxydocosanoic acid and a linear polyester film is formed by 9, (10)-monohydroxyoctadecanoic acid and 13(14)-monohydroxydocosanoic acid.

VizieR Online Data Catalog: Swift and NuSTAR obs. of the BL Lac Mrk 421 (Kapanadze+, 2016)

NASA Astrophysics Data System (ADS)

Kapanadze, B.; Dorner, D.; Vercellone, S.; Romano, P.; Aller, H.; Aller, M.; Hughes, P.; Reynolds, M.; Kapanadze, S.; Tabagari, L.

2017-01-01

We retrieved the Swift-XRT data from the publicly available archive, maintained by HEASARC. We present the results of X-ray observations of the high-energy peaked BL Lac (HBL) source Mrk421 performed by Swift-XRT and NuSTAR during 2013 January-June. Along with the 0.3-10keV and 3-79keV data obtained with the Swift-XRT and NuSTAR instruments, we have processed and analyzed those obtained with the Ultraviolet-Optical Telescope (UVOT) and Large Area Telescope (LAT) onboard Fermi. We have also used the publicly available light curves from the observations performed with the Burst Alert Telescope (BAT) onboard Swift, Monitor of All Sky X-ray Image (MAXI), MAGIC, First G-APD Cherenkov Telescope (FACT), and the OVRO 40m telescope during the 2013 January-June period to draw conclusions about the interband correlations. (8 data files).

Microwave Acoustics Handbook. Volume 4. Bulk Wave Velocities-Numerical Data.

DTIC Science & Technology

1980-06-01

p .00 * a* *~ Ol r4 000a1 .C e e0 0 C ~ armC aeC PSFCU NU . FPS WF w N C ’O’ w N 0 0 It1 P SNF .4.64 *.4 F7 N P C L *- P U NF L 6 .184 * ff .UULUFUJ...1010 10 7.7.N𔃽f3.7.s 34.3.3.3.3 U5 IL I 4 0 * 0t * t ** * t ** *7 * * . A 7)..00a00UN03 . f7 ) UN7.030*4 30 .4 *000 4m 0 M 3.0 030a. w tr 300a, a,7M 7... acca :00 C0 0 0 w l . r C O r . C t. . C=c c t r a r a e C N .4 *0 NNONU’ C’ 0’C N 4* P 00£.4.40 N 40’ N NU . 4w C N ’ O . N 4 N C ’t C U lo. ’ U

Interest of analyses of heart rate variability in the prevention of fatigue states in senior runners.

PubMed

Leti, Thomas; Bricout, Véronique A

2013-01-01

The use of heart rate variability (HRV) in the management of sport training is a practice which tends to spread, especially in order to prevent the occurrence of fatigue states. To estimate the HRV parameters obtained using a heart rate recording, according to different exercise impacts, and to make the link with the appearance of subjective fatigue. Ten senior runners, aged 51±5 years, were each monitored over a period of 12 weeks in different conditions: (i) after a resting period, (ii) after a day with training, (iii) after a day of competition and (iv) after a rest day. They also completed three questionnaires, to assess fatigue (SFMS), profile of mood states (POMS) and quality of sleep. The HRV indices (heart rate, LF (n.u.), HF (n.u.) and LF/HF) were significantly altered with the competitive impact, shifting toward a sympathetic predominance. After rest and recovery nights, the LF (n.u.) increased significantly with the competitive impact (62.1±15.2 and 66.9±11.6 vs. 76.0±10.7; p<0.05 respectively) whereas the HF (n.u.) decreased significantly (37.9±15.2 and 33.1±11.6 vs. 24.0±10.7; p<0.05 respectively). Positive correlations were found between fatigue and frequency domain indices and between fatigue and training impact. Autonomic nervous system modulation-fatigue relationships were significant, suggesting the potential use of HRV in follow-up and control of training. Furthermore, the addition of questionnaires constitutes complementary tools that allow to achieve a greater relevance and accuracy of the athletes' fitness and results. Copyright © 2012 Elsevier B.V. All rights reserved.

Characterisation of baroreflex sensitivity of recreational ultra-endurance athletes.

PubMed

Foulds, Heather J A; Cote, Anita T; Phillips, Aaron A; Charlesworth, Sarah A; Bredin, Shannon S D; Burr, Jamie F; Drury, Chipman Taylor; Ngai, Shirley; Fougere, Renee J; Ivey, Adam C; Warburton, Darren E R

2014-01-01

Altered autonomic function has been identified following ultra-endurance event participation among elite world-class athletes. Despite dramatic increases in recreational athlete participation in these ultra-endurance events, the physiological effects on these athletes are less known. This investigation sought to characterise changes in surrogate measures of autonomic function: heart rate variability (HRV), blood pressure variability (BPV) and baroreceptor sensitivity (BRS) following ultra-endurance race participation. Further, we sought to compare baseline measures among ultra-endurance athletes and recreationally active controls not participating in the ultra-endurance race. Recreational ultra-endurance athletes (n = 25, 44.6 ± 8.2 years, 8 females) and recreationally active age, sex and body mass index matched controls (n = 25) were evaluated. Measurements of HRV, BPV and BRS were collected pre- and post-race for recreational ultra-endurance athletes and at baseline, for recreationally active controls. Post-race, ultra-endurance athletes demonstrated significantly greater sympathetic modulation [low frequency (LF) power HRV: 50.3 ± 21.6 normalised units (n.u.) to 65.9 ± 20.4 n.u., p = 0.01] and significantly lower parasympathetic modulation [high frequency (HF) power HRV: 45.0 ± 22.4 n.u. to 23.9 ± 13.1 n.u., p < 0.001] and BRS. Baseline measurements BRS (spectral: 13.96 ± 10.82 ms·mmHg(-1) vs. 11.39 ± 5.33 ms·mmHg(-1)) were similar among recreational ultra-endurance athletes and recreationally active controls, though recreational ultra-endurance athletes demonstrated greater parasympathetic modulation of some HRV and BPV measures. Recreational ultra-endurance athletes experienced increased sympathetic tone and declines in BRS post-race, similar to previously reported elite world-class ultra-endurance athletes, though still within normal population ranges.

KSC-2012-1239

NASA Image and Video Library

2012-02-02

VANDENBERG AIR FORCE BASE, Calif. -- Workers unload the two halves that make up the Pegasus XL rocket's fairing that will protect the NuSTAR spacecraft during launch. Inside Orbital Science's processing facility, the fairing halves will be unwrapped and processed in a clean room environmental enclosure. The Pegasus is set to launch NASA's NuSTAR spacecraft. Once the rocket and spacecraft are processed at Vandenberg, they will be flown on the Orbital Sciences’ L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean’s Kwajalein Atoll for launch. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit science.nasa.gov/missions/nustar/. Photo credit: NASA/Randy Beaudoin, VAFB

A Functional Relationship between NuMA and Kid Is Involved in Both Spindle Organization and Chromosome Alignment in Vertebrate CellsV⃞

PubMed Central

Levesque, Aime A.; Howard, Louisa; Gordon, Michael B.; Compton, Duane A.

2003-01-01

We examined spindle morphology and chromosome alignment in vertebrate cells after simultaneous perturbation of the chromokinesin Kid and either NuMA, CENP-E, or HSET. Spindle morphology and chromosome alignment after simultaneous perturbation of Kid and either HSET or CENP-E were no different from when either HSET or CENP-E was perturbed alone. However, short bipolar spindles with organized poles formed after perturbation of both Kid and NuMA in stark contrast to splayed spindle poles observed after perturbation of NuMA alone. Spindles were disorganized if Kid, NuMA, and HSET were perturbed, indicating that HSET is sufficient for spindle organization in the absence of Kid and NuMA function. In addition, chromosomes failed to align efficiently at the spindle equator after simultaneous perturbation of Kid and NuMA despite appropriate kinetochore-microtubule interactions that generated chromosome movement at normal velocities. These data indicate that a functional relationship between the chromokinesin Kid and the spindle pole organizing protein NuMA influences spindle morphology, and we propose that this occurs because NuMA forms functional linkages between kinetochore and nonkinetochore microtubules at spindle poles. In addition, these data show that both Kid and NuMA contribute to chromosome alignment in mammalian cells. PMID:12972545

Experimental study of turbulent flow heat transfer and pressure drop in a plate heat exchanger with chevron plates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muley, A.; Manglik, R.M.

1997-07-01

Experimental data for isothermal pressure drop and heat transfer in single-phase water flows in a plate heat exchanger (PHE) with chevron plates are presented. A single-pass, U-type, counterflow PHE, with three different chevron plate arrangements is employed: two symmetric plate arrangements with {beta} = 30/30{degree} and 60/60{degree}, and a mixed-plate arrangement with {beta} = 30/60{degree}. With water flow rates in the turbulent flow regime (600 < Re < 10{sup 4} and 2 < Pr < 6), effects of the chevron corrugation inclination angle {beta} on Nu and f characteristics of the PHE are investigated. As {beta} increases and compared tomore » a flat-plate pack, up to 2 to 5 times higher Nu are obtained; the concomitant f, however, are 13 to 44 times higher. Based on the experimental data for Re {le} 1,000, predictive correlations of the form Nu = C{sub 1}{beta} Re{sup p1({beta})} Pr{sup 1/3} ({mu}/{mu}{sub w}){sup 0.14} and f = C{sub 2}{beta} Re{sup p2({beta})} are devised. Also, at constant pumping power and depending upon {beta}, the heat transfer is found to be enhanced over 1.8 times that in equivalent flat-plate channels.« less

Retrospective Study of Retention of Stainless Steel Crowns and Pre-veneered Crowns on Primary Anterior Teeth.

PubMed

Lopez-Loverich, Angela M; Garcia, Maria Minerva; Donly, Kevin J

2015-01-01

The purpose of this retrospective chart review was to explore the retention of anterior pre-veneered stainless steel crowns (NuSmile) and conventional stainless steel crowns (3M ESPE) placed on primary anterior teeth. Records for children were reviewed over four years using the electronic record system axiUm. Data collected included child's age at time of crown placement, date of placement, tooth number, type of crown, patient behavior, treatment environment, provider type, crown presence, absence, and cementation success or failure at subsequent recall visits. A total of 637 anterior crowns in children treated with either or both crown types met this study's inclusion criteria. Of these crowns, 483 were NuSmile Signature crowns and 154 were stainless steel crowns. There was a nine percent failure rate for the NuSmile Signature crowns and a seven percent failure rate for the stainless steel crowns. There was no statistically significant difference in crown retention rates between the two groups (P<0.05). A full-coverage restoration that can follow the lifespan of the primary anterior dentition in high-risk children is needed. The results from this study indicate good crown retention rates for both crown types with no statistically significant difference between them (P<0.05).

KSC-2012-1360

NASA Image and Video Library

2012-02-16

VANDENBERG AIR FORCE BASE, Calif. -- NuSTAR’s X-ray telescope is visible during the solar array deployment test at Vandenberg Air Force Base's processing facility in California. The Pegasus will launch NASA's Nuclear Spectroscopic Telescope Array NuSTAR into space. After the rocket and spacecraft are processed at Vandenberg, they will be flown on the Orbital Sciences’ L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean’s Kwajalein Atoll for launch. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit science.nasa.gov/missions/nustar/. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1358

NASA Image and Video Library

2012-02-16

VANDENBERG AIR FORCE BASE, Calif. -- As a technician monitors the solar array deployment test at Vandenberg Air Force Base's processing facility in California, NuSTAR’s X-ray telescope is visible. The Pegasus will launch NASA's Nuclear Spectroscopic Telescope Array NuSTAR into space. After the rocket and spacecraft are processed at Vandenberg, they will be flown on the Orbital Sciences’ L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean’s Kwajalein Atoll for launch. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit science.nasa.gov/missions/nustar/. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1359

NASA Image and Video Library

2012-02-16

VANDENBERG AIR FORCE BASE, Calif. -- As a technician monitors the solar array deployment test at Vandenberg Air Force Base's processing facility in California, NuSTAR’s X-ray telescope is visible. The Pegasus will launch NASA's Nuclear Spectroscopic Telescope Array NuSTAR into space. After the rocket and spacecraft are processed at Vandenberg, they will be flown on the Orbital Sciences’ L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean’s Kwajalein Atoll for launch. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit science.nasa.gov/missions/nustar/. Photo credit: NASA/Randy Beaudoin, VAFB

Effect due to charge symmetry violation on the Paschos-Wolfenstein relation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ding Yong; Ma Boqiang; CCAST

2006-03-01

The modification of the Paschos-Wolfenstein relation is investigated when the charge symmetry violations of valence and sea quark distributions in the nucleon are taken into account. We also study qualitatively the impact of charge symmetry violation (CSV) effect on the extraction of sin{sup 2}{theta}{sub w} from deep-inelastic neutrino- and antineutrino-nuclei scattering within the light-cone meson-baryon fluctuation model. We find that the effect of CSV is too small to give a sizable contribution to the NuTeV result with various choices of mass difference inputs, which is consistence with the prediction that the strange-antistrange asymmetry can account for largely the NuTeV deviationmore » in this model. It is noticeable that the effect of CSV might contribute to the NuTeV deviation when the larger difference between the internal momentum scales, {alpha}{sub p} of the proton and {alpha}{sub n} of the neutron, is considered.« less

Spectral investigations of amino acid picrates.

PubMed

Briget Mary, M; Sasirekha, V; Ramakrishnan, V

2006-10-01

FTIR and laser Raman spectra of beta-alanine beta-alaninium picrate and dl-phenylalanine dl-phenylalaninium picrate crystals of space group P1 (C(i)) have been me in the 4000-50 cm(-1) range, at room temperature. The former crystal consists of beta-alanine beta-alaninium and the later dl-phenylalanine dl-phenylalaninium as cations. The presence of both carbonyl (CO) and carboxylate COO(-) groups in these crystals is the evidence for the existence of the zwitterion and the protonated forms. Factor group analysis has been made and the numbers of vibrational modes have been calculated. The tentative assignments of the observed bands are given. Fermi resonance has also been observed in one of the crystal beta-alanine beta-alaninium picrate. The picrate group forms the anion in both crystals and the characteristic bands nu(as)NO(2), nu(s)NO(2), and nu(phen)C-O stretching are observed in the spectra. These suggest that the picrate ion is unaffected by the presence of the cations.

Infrared resonance Raman, and excitation profile studies of Os/sub 2/(O/sub 2/CCH/sub 3/)/sub 4/Cl/sub 2/ and Os/sub 2/(O/sub 2/CCD/sub 3/)/sub 4/Cl/sub 2/. The assignment of the osmium-osmium stretching vibration for a complex involving an osmium-osmium multiple bond

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clark, R.J.H.; Hempleman, A.J.; Tocher, D.A.

1988-08-31

Extensive Raman studies (1525-40 cm/sup /minus/1/) of Os/sub 2/(O/sub 2/CCH/sub 3/)/sub 4/Cl/sub 2/ have led to the identification of the three strong bands, /nu//sub 1/, /nu//sub 2/, and /nu//sub 3/, at 229, 393, and 292 cm/sup /minus/1/ to the key skeletal stretching modes, /nu/(OsOs), /nu/(OsO), and /nu/(OsCl), respectively. Raman spectra of the complex at resonance with the intense electronic band at /lambda//sub max/ = 383 nm lead to the development of a six-membered overtone progression in /nu//sub 1/ as well as combination band progressions in /nu//sub 1/ based upon one quantum of either /nu//sub 2/ or /nu//sub 3/. This indicatesmore » that the principal structural change attendant upon excitation to the resonant state is along the OsOs coordinate. Fourier transform infrared spectra (3500-40 cm/sup /minus/1/) have also been obtained. Acetate deuteriation provides conclusive evidence for many of the infrared and Raman band assignments. The study provides the first firm identification of /nu/(OsOs) for a multiply bonded species.« less

[Influence of macrophages on the expression of vascular endothelial growth factor receptor mRNA, homeobox B2 mRNA, and integrin alpha nu beta3 in vascular endothelial strain].

PubMed

Liu, Liang; Liu, Chang; Zhang, Xiao-qi; Ming, Jia; Liu, Xu-sheng; Xu, Hui; Cheng, Tian-min

2005-06-01

To investigate the influence of macrophages on the expression of the vascular endothelial growth factor (VEGF) receptor (KDR) mRNA, homeobox B2 (HOXB2) mRNA, and integrin alpha nu beta3 in vitro in vascular endothelial strain. Human umbilical vein cells (ECV304) were cultured in vitro and divided into 4 groups, i.e. (1) ECV304 group, (2) ECV304 + conA group [with conA (25 microg/ml in culture) added to ECV304], (3) ECV304 + U937 group (with 1 x 10(5)/ml of U937 cells added to 1 x 10(5)/ml ECV 304), (4) ECV304 + U937 + conA group [with 1 x 10(5)/ml of U937 cells and conA (25 microg/ml in culture)] groups. Forty-eight hours after culturing, the expression of integrin receptor alpha nu beta3 and the changes in the expression of KDR mRNA and HOXB2 mRNA in each group were determined by immunofluorescent technique and RT-PCR, respectively. The expression of integrin receptor alpha nu beta3, KDR mRNA, and HOXB2 mRNA in ECV304 group were 6.7 +/- 1.5, 0.633 +/- 0.012, and 0.674 +/- 0.004, respectively, while those in ECV304 + U937 + conA group (10.2 +/- 1.7, 0.879 +/- 0.003, 0.947 +/- 0.003) were obviously more upregulated when compared with those in ECV304 group (P < 0.01). No difference in the above indices was found between ECV304 and ECV304 + conA, ECV304 + U937 groups (P > 0.05). Macrophages activated by ConA can accelerate the proliferation, migration and adhesion to the basement membrane matrix of vascular endothelial cells through the influence on the expression of KDR mRNA, HOXB2 mRNA and integrin alpha nu beta3, and through this pathway the angiogenesis is modulated.

[Study on effect of jinshui liujun jian oral liquid on serum superoxide dismutase activity and malonyldialdehyde content in mice with chronic bronchitis].

PubMed

Zhao, C Y; Shen, Y S; Meng, H

2001-11-01

To study the effect of Jinshui Liujun Jian Oral Liquid (JLJOL) on serum superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) content in mice with chronic bronchitis. JLJOL was given to the chronic bronchitis mice model (induced by smoking) through gastrogavage, and then SOD activity and MDA content were tested. SOD activity in model mice after JLJOL treatment was 0.67 +/- 0.15 NU/L, which was significantly higher than that in the untreated model (0.39 +/- 0.13 NU/L, P < 0.01). But the MDA content in treated mice was significantly lower than that in untreated one (9.26 +/- 2.90 nmol/L vs 16.07 +/- 5.62 nmol/L, P < 0.01). JLJOL could scavenge the injury of free radical on organism.

The Factor Structure and Psychometric Properties of the Persian Version of the Revised Prenatal Coping Inventory (Nu-PCI).

PubMed

Faramarzi, Mahbobeh; Pasha, Hajar; Khafri, Sorayya; Heidary, Shima

2017-03-01

Familiarity with coping strategies is essential for stress management during pregnancy. The Revised Prenatal Coping Inventory (Nu-PCI) was developed to assess coping strategies during pregnancy. This study aimed to assess the factor structure and psychometric properties of the Persian version of the Nu-PCI. After forward-backward translation, the Nu-PCI was administered to 210 pregnant women who were enrolled in two teaching referral clinics in the North of the Islamic Republic of Iran (Babol). The participants completed the Persian Nu-PCI and Ways of Coping Questionnaire (WCQ), which was used to determine the validity of the Persian Nu-PCI. To test construct validity of the Persian Nu-PCI, a principal components factor analysis was performed. Principal components analysis with varimax rotation showed a best fitting 3-factor structure similar to the original with three coping subscales: planning-preparation, avoidance, and spiritual-positive coping. The Persian Nu-PCI was internally consistent and within the acceptable range (α=0.89-0.97). The alpha coefficients for the Nu-PCI and the subscales of planning-preparation, avoidance, and spiritual-positive coping were high. Test-retest coefficients for the Nu-PCI and subscales were 0.98-0.99. The Nu-PCI and its subscales correlated with the WCQ in the entire sample and within each trimester. The Persian version of the Nu-PCI and the subscales of planning-preparation, avoidance, and spiritual-positive coping represent the first reliable standardized tool for measuring coping strategies during pregnancy in the Islamic Republic of Iran. Therefore, it can be applied as a quick and accurate preliminary screening tool for evaluating coping strategies throughout pregnancy in clinics and other medical and research settings.

Resolution of puzzles from the LSND, KARMEN, and MiniBooNE experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gninenko, S. N.

2011-01-01

This work has attempted to reconcile puzzling neutrino oscillation results from the LSND, KARMEN, and MiniBooNE experiments. We show that the LSND evidence for {nu}{sub {mu}}{yields}{nu}e oscillations, its long-standing disagreement with the results from KARMEN, and the anomalous event excess observed by MiniBooNE in {nu}{sub {mu}} and {nu}{sub {mu}} data could all be explained by the existence of a heavy sterile neutrino ({nu}{sub h}). All these results are found to be consistent with each other, assuming that the {nu}{sub h} is created in {nu}{sub {mu}} neutral-current interactions and decays radiatively into a photon and a light neutrino. Assuming the {nu}{submore » h} is produced through mixing with {nu}{sub {mu}}, the combined analysis of the LSND and MiniBooNe excess events suggests that the {nu}{sub h} mass is in the range from 40 to 80 MeV, the mixing strength is |U{sub {mu}h}|{sup 2{approx_equal}}10{sup -3}-10{sup -2}, and the lifetime is {tau}{sub {nu}{sub h}} < or approx. 10{sup -9} s. Surprisingly, this LSND-MiniBooNE parameter window is found to be unconstrained by the results from the most sensitive experiments. We set new limits on |U{sub {mu}h}|{sup 2} for the favorable mass region from the precision measurements of the Michel spectrum by the TWIST experiment. The results obtained provide a strong motivation for a sensitive search for the {nu}{sub h} in a near future K decay or neutrino experiments, which fit well in the existing and planned experimental programs at CERN or FNAL. The question of whether the heavy neutrino is a Dirac or Majorana particle is briefly discussed.« less

A Search for the Decay B+ --> K+ nu nubar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aubert, B

In this work the authors report the results of a search for the exclusive decay mode B{sup +} --> K{sup +}{nu}{bar {nu}}. By modifying the particle identification (PID) criteria used in the search, they additionally obtain a limit on the related decay B{sup +} --> {pi}{sup +}{nu}{bar {nu}}. The data used in this analysis were collected with the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} storage ring.

Performance test and image correction of CMOS image sensor in radiation environment

NASA Astrophysics Data System (ADS)

Wang, Congzheng; Hu, Song; Gao, Chunming; Feng, Chang

2016-09-01

CMOS image sensors rival CCDs in domains that include strong radiation resistance as well as simple drive signals, so it is widely applied in the high-energy radiation environment, such as space optical imaging application and video monitoring of nuclear power equipment. However, the silicon material of CMOS image sensors has the ionizing dose effect in the high-energy rays, and then the indicators of image sensors, such as signal noise ratio (SNR), non-uniformity (NU) and bad point (BP) are degraded because of the radiation. The radiation environment of test experiments was generated by the 60Co γ-rays source. The camera module based on image sensor CMV2000 from CMOSIS Inc. was chosen as the research object. The ray dose used for the experiments was with a dose rate of 20krad/h. In the test experiences, the output signals of the pixels of image sensor were measured on the different total dose. The results of data analysis showed that with the accumulation of irradiation dose, SNR of image sensors decreased, NU of sensors was enhanced, and the number of BP increased. The indicators correction of image sensors was necessary, as it was the main factors to image quality. The image processing arithmetic was adopt to the data from the experiences in the work, which combined local threshold method with NU correction based on non-local means (NLM) method. The results from image processing showed that image correction can effectively inhibit the BP, improve the SNR, and reduce the NU.

Power spectral analysis of heart rate in hyperthyroidism.

PubMed

Cacciatori, V; Bellavere, F; Pezzarossa, A; Dellera, A; Gemma, M L; Thomaseth, K; Castello, R; Moghetti, P; Muggeo, M

1996-08-01

The aim of the present study was to evaluate the impact of hyperthyroidism on the cardiovascular system by separately analyzing the sympathetic and parasympathetic influences on heart rate. Heart rate variability was evaluated by autoregressive power spectral analysis. This method allows a reliable quantification of the low frequency (LF) and high frequency (HF) components of the heart rate power spectral density; these are considered to be under mainly sympathetic and pure parasympathetic control, respectively. In 10 newly diagnosed untreated hyperthyroid patients with Graves' disease, we analyzed power spectral density of heart rate cyclic variations at rest, while lying, and while standing. In addition, heart rate variations during deep breathing, lying and standing, and Valsalva's maneuver were analyzed. The results were compared to those obtained from 10 age-, sex-, and body mass index-matched control subjects. In 8 hyperthyroid patients, the same evaluation was repeated after the induction of stable euthyroidism by methimazole. Heart rate power spectral analysis showed a sharp reduction of HF components in hyperthyroid subjects compared to controls [lying, 13.3 +/- 4.1 vs. 32.0 +/- 5.6 normalized units (NU; P < 0.01); standing, 6.0 +/- 2.7 vs. 15.0 +/- 4.0 NU (P < 0.01); mean +/- SEM]. On the other hand components were comparable in the 2 groups (lying, 64.0 +/- 6.9 vs. 62.0 +/- 6.5 NU; standing, 77.0 +/- 6.5 vs. 78.0 +/- 5.4 NU). Hence, the LF/HF ratio, which is considered an index of sympathovagal balance, was increased in hyperthyroid subjects while both lying (11.3 +/- 4.5 vs. 3.5 +/- 1.1; P < 0.05) and standing (54.0 +/- 12.6 vs. 9.8 +/- 2.6; P < 0.02). This parameter was positively correlated with both T3 (r = 0.61; P < 0.05) and free T4 (r = 0.63; P < 0.05) serum levels. Among traditional cardiovascular autonomic tests, the reflex response of heart rate during lying to standing was significantly lower in hyperthyroid patients than in controls (1.12 +/- 0.03 vs. 1.31 +/- 0.04; P < 0.002). No statistically significant difference in reflex responses between the two groups was found in deep breathing or Valsalva's maneuver. In the 8 patients reexamined after methimazole treatment, we observed complete normalization of altered cardiovascular parameters, with slight predominance of the vagal component compared with controls. These results suggest that thyroid hormone excess may determine reduced parasympathetic activity and, thus, a relative hypersympathetic tone.

Comparison of Dosimetric and Biologic Effective Dose Parameters for Prostate and Urethra Using {sup 131}Cs and {sup 125}I for Prostate Permanent Implant Brachytherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sahgal, Arjun; Department of Radiation Oncology, Odette Cancer Centre at Sunnybrook Hospital, University of Toronto, Toronto, ON; Jabbari, Siavash

2008-09-01

Purpose: To compare the urethral and prostate absolute and biologic effective doses (BEDs) for {sup 131}Cs and {sup 125}I prostate permanent implant brachytherapy (PPI). Methods and Materials: Eight previously implanted manually planned {sup 125}I PPI patients were replanned manually with {sup 131}Cs, and re-planned using Inverse Planning Simulated Annealing. {sup 131}Cs activity and the prescribed dose (115 Gy) were determined from that recommended by IsoRay. The BED was calculated for the prostate and urethra using an {alpha}/{beta} ratio of 2 and was also calculated for the prostate using an {alpha}/{beta} ratio of 6 and a urethral {alpha}/{beta} ratio of 2.more » The primary endpoints of this study were the prostate D{sub 90} BED (pD{sub 90}BED) and urethral D{sub 30} BED normalized to the maximal potential prostate D{sub 90} BED (nuD{sub 30}BED). Results: The manual plan comparison ({alpha}/{beta} = 2) yielded no significant difference in the prostate D{sub 90} BED (median, 192 Gy{sub 2} for both isotopes). No significant difference was observed for the nuD{sub 30}BED (median, 199 Gy{sub 2} and 202 Gy{sub 2} for {sup 125}I and {sup 131}Cs, respectively). For the inverse planning simulated annealing plan comparisons ({alpha}/{beta} 2), the prostate D{sub 90} BED was significantly lower with {sup 131}Cs than with {sup 125}I (median, 177 Gy{sub 2} vs. 187 Gy{sub 2}, respectively; p = 0.01). However, the nuD{sub 30}BED was significantly greater with {sup 131}Cs than with {sup 125}I (median, 192 Gy{sub 2} vs. 189 Gy{sub 2}, respectively; p = 0.01). Both the manual and the inverse planning simulated annealing plans resulted in a significantly lower prostate D{sub 90} BED (p = 0.01) and significantly greater nuD{sub 30}BED for {sup 131}Cs (p = 0.01), compared with {sup 125}I, when the prostate {alpha}/{beta} ratio was 6 and the urethral {alpha}/{beta} ratio was 2. Conclusion: This report highlights the controversy in comparing the dose to both the prostate and the organs at risk with different radionuclides.« less

Conductivity predictions for the 5/2 fractional quantum Hall state using the composite fermion superconductor model

NASA Astrophysics Data System (ADS)

Foster, Kerwin Crayton

The fractional quantum Hall effect (FQHE) occurs when a two-dimensional electron gas is placed in a strong magnetic field at low temperatures. When this effect occurs the Hall resistance, RH, defined to be the Hall voltage divided by the current, is quantized, with RH = (1/nu)h/ e2 where nu = p/q is the Landau level filling fraction; and p and q are relatively prime integers. For almost all observed FQHE states, q is odd with one notable exception: the nu = 5/2 FQHE state. Understanding the nature of this incompressible even-denominator state is one of the central questions in the theory of the FQHE and is the subject of this Dissertation. We use a powerful theoretical tool for studying the FQHE: composite fermion theory. Composite fermions can be viewed as electrons bound to an even number of magnetic flux quanta. Jain has shown that the FQHE for electrons can be viewed as an integer quantum Hall effect (p = 1) for composite fermions. More recently, Halperin, Lee and Read developed a successful theory of the compressible nu = 1/2 state using composite fermions. There is now compelling theoretical evidence that the 5/2 state is a so-called Moore-Read state---a state which can be viewed as a spin-polarized p-wave superconductor of composite fermions. We have developed a semi-phenomenological description of this state by modifying the Halperin-Lee-Read theory, adding a p-wave pairing interaction between composite fermions by hand. The electromagnetic response functions for the resulting superconducting state of composite fermions are then calculated. We show that these response functions exhibit the expected BCS 'coherence factor' effects, such as the Hebel-Slichter peak. Using the composite fermion response functions, we then calculate the corresponding electronic response functions using Chern-Simons theory. We find that in the electronic response, the most striking coherence factor effects (e.g., the Hebel-Slichter peak) are strongly suppressed. However, the low-temperature o = 2Delta threshold behavior does show clear coherence factor effects. Finally, we use our model to predict the wave-vector and frequency dependence of the longitudinal conductivity, sigmaxx( q, o), which can be measured in surface-acoustic-wave propagation experiments.

Measurement of |V(cb)| and the form-factor slope in B --> Dl- nu(l) decays in events tagged by a fully reconstructed B meson.

PubMed

Aubert, B; Karyotakis, Y; Lees, J P; Poireau, V; Prencipe, E; Prudent, X; Tisserand, V; Garra Tico, J; Grauges, E; Martinelli, M; Palano, A; Pappagallo, M; Eigen, G; Stugu, B; Sun, L; Battaglia, M; Brown, D N; Kerth, L T; Kolomensky, Yu G; Lynch, G; Osipenkov, I L; Tackmann, K; Tanabe, T; Hawkes, C M; Soni, N; Watson, A T; Koch, H; Schroeder, T; Asgeirsson, D J; Fulsom, B G; Hearty, C; Mattison, T S; McKenna, J A; Barrett, M; Khan, A; Randle-Conde, A; Blinov, V E; Bukin, A D; Buzykaev, A R; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Martin, E C; Stoker, D P; Atmacan, H; Gary, J W; Liu, F; Long, O; Vitug, G M; Yasin, Z; Zhang, L; Sharma, V; Campagnari, C; Hong, T M; Kovalskyi, D; Mazur, M A; Richman, J D; Beck, T W; Eisner, A M; Heusch, C A; Kroseberg, J; Lockman, W S; Martinez, A J; Schalk, T; Schumm, B A; Seiden, A; Wang, L; Winstrom, L O; Cheng, C H; Doll, D A; Echenard, B; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Andreassen, R; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Bloom, P C; Ford, W T; Gaz, A; Hirschauer, J F; Nagel, M; Nauenberg, U; Smith, J G; Wagner, S R; Ayad, R; Toki, W H; Wilson, R J; Feltresi, E; Hauke, A; Jasper, H; Karbach, T M; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Kobel, M J; Nogowski, R; Schubert, K R; Schwierz, R; Volk, A; Bernard, D; Latour, E; Verderi, M; Clark, P J; Playfer, S; Watson, J E; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Fioravanti, E; Franchini, P; Luppi, E; Munerato, M; Negrini, M; Petrella, A; Piemontese, L; Santoro, V; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Contri, R; Guido, E; Lo Vetere, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Tosi, S; Chaisanguanthum, K S; Morii, M; Adametz, A; Marks, J; Schenk, S; Uwer, U; Bernlochner, F U; Klose, V; Lacker, H M; Bard, D J; Dauncey, P D; Tibbetts, M; Behera, P K; Charles, M J; Mallik, U; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gao, Y Y; Gritsan, A V; Guo, Z J; Arnaud, N; Béquilleux, J; D'Orazio, A; Davier, M; Derkach, D; da Costa, J Firmino; Grosdidier, G; Le Diberder, F; Lepeltier, V; Lutz, A M; Malaescu, B; Pruvot, S; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wormser, G; Lange, D J; Wright, D M; Bingham, I; Burke, J P; Chavez, C A; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Touramanis, C; Bevan, A J; Clarke, C K; Di Lodovico, F; Sacco, R; Sigamani, M; Cowan, G; Paramesvaran, S; Wren, A C; Brown, D N; Davis, C L; Denig, A G; Fritsch, M; Gradl, W; Hafner, A; Alwyn, K E; Bailey, D; Barlow, R J; Jackson, G; Lafferty, G D; West, T J; Yi, J I; Anderson, J; Chen, C; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Dallapiccola, C; Salvati, E; Saremi, S; Cowan, R; Dujmic, D; Fisher, P H; Henderson, S W; Sciolla, G; Spitznagel, M; Yamamoto, R K; Zhao, M; Patel, P M; Robertson, S H; Schram, M; Lazzaro, A; Lombardo, V; Palombo, F; Stracka, S; Bauer, J M; Cremaldi, L; Godang, R; Kroeger, R; Sonnek, P; Summers, D J; Zhao, H W; Simard, M; Taras, P; Nicholson, H; De Nardo, G; Lista, L; Monorchio, D; Onorato, G; Sciacca, C; Raven, G; Snoek, H L; Jessop, C P; Knoepfel, K J; LoSecco, J M; Wang, W F; Corwin, L A; Honscheid, K; Kagan, H; Kass, R; Morris, J P; Rahimi, A M; Regensburger, J J; Sekula, S J; Wong, Q K; Blount, N L; Brau, J; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Castelli, G; Gagliardi, N; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Sanchez, P del Amo; Ben-Haim, E; Bonneaud, G R; Briand, H; Chauveau, J; Hamon, O; Leruste, Ph; Marchiori, G; Ocariz, J; Perez, A; Prendki, J; Sitt, S; Gladney, L; Biasini, M; Manoni, E; Angelini, C; Batignani, G; Bettarini, S; Calderini, G; Carpinelli, M; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Pegna, D Lopes; Lu, C; Olsen, J; Smith, A J S; Telnov, A V; Anulli, F; Baracchini, E; Cavoto, G; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, P D; Gioi, L Li; Mazzoni, M A; Morganti, S; Piredda, G; Renga, F; Voena, C; Ebert, M; Hartmann, T; Schröder, H; Waldi, R; Adye, T; Franek, B; Olaiya, E O; Wilson, F F; Emery, S; Esteve, L; de Monchenault, G Hamel; Kozanecki, W; Vasseur, G; Yèche, Ch; Zito, M; Allen, M T; Aston, D; Bartoldus, R; Benitez, J F; Cenci, R; Coleman, J P; Convery, M R; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Field, R C; Sevilla, M Franco; Gabareen, A M; Graham, M T; Grenier, P; Hast, C; Innes, W R; Kaminski, J; Kelsey, M H; Kim, H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Lindquist, B; Luitz, S; Luth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Muller, D R; Neal, H; Nelson, S; O'Grady, C P; Ofte, I; Perl, M; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Va'vra, J; Wagner, A P; Weaver, M; West, C A; Wisniewski, W J; Wittgen, M; Wright, D H; Wulsin, H W; Yarritu, A K; Young, C C; Ziegler, V; Chen, X R; Liu, H; Park, W; Purohit, M V; White, R M; Wilson, J R; Burchat, P R; Edwards, A J; Miyashita, T S; Ahmed, S; Alam, M S; Ernst, J A; Pan, B; Saeed, M A; Zain, S B; Soffer, A; Spanier, S M; Wogsland, B J; Eckmann, R; Ritchie, J L; Ruland, A M; Schilling, C J; Schwitters, R F; Wray, B C; Drummond, B W; Izen, J M; Lou, X C; Bianchi, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martinez-Vidal, F; Milanes, D A; Oyanguren, A; Albert, J; Banerjee, Sw; Bhuyan, B; Choi, H H F; Hamano, K; King, G J; Kowalewski, R; Lewczuk, M J; Nugent, I M; Roney, J M; Sobie, R J; Gershon, T J; Harrison, P F; Ilic, J; Latham, T E; Mohanty, G B; Puccio, E M T; Band, H R; Chen, X; Dasu, S; Flood, K T; Pan, Y; Prepost, R; Vuosalo, C O; Wu, S L

2010-01-08

We present a measurement of the Cabibbo-Kobayashi-Maskawa matrix element |V(cb)| and the form-factor slope rho2 in B --> Dl- nu(l) decays based on 460x10(6) BB events recorded at the Upsilon(4S) resonance with the BABAR detector. B --> Dl- nu(l) decays are selected in events in which a hadronic decay of the second B meson is fully reconstructed. We measure B(B- --> D0 l- nu(l))/B(B- --> Xl- nu(l)) = (0.255+/-0.009+/-0.009) and B(B0 --> D+ l- nu(l))/B(B0 --> Xl- nu(l)) = (0.230+/-0.011+/-0.011), along with the differential decay distribution in B --> Dl- nu(l) decays. We then determine G(1)|V(cb)| = (42.3+/-1.9+/-1.4)x10(-3) and rho2 = 1.20+/-0.09+/-0.04, where G(1) is the hadronic form factor at the point of zero recoil.

Optical emission spectroscopic diagnostics of a non-thermal atmospheric pressure helium-oxygen plasma jet for biomedical applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thiyagarajan, Magesh; Sarani, Abdollah; Nicula, Cosmina

In this work, we have applied optical emission spectroscopy diagnostics to investigate the characteristics of a non-thermal atmospheric pressure helium plasma jet. The discharge characteristics in the active and afterglow region of the plasma jet, that are critical for biomedical applications, have been investigated. The voltage-current characteristics of the plasma discharge were analyzed and the average plasma power was measured to be around 18 W. The effect of addition of small fractions of oxygen at 0.1%-0.5% on the plasma jet characteristics was studied. The addition of oxygen resulted in a decrease in plasma plume length due to the electronegativity propertymore » of oxygen. Atomic and molecular lines of selected reactive plasma species that are considered to be useful to induce biochemical reactions such as OH transitions A{sup 2}{Sigma}{sup +}({nu}=0,1){yields}X{sup 2}{Pi}({Delta}{nu}=0) at 308 nm and A{sup 2}{Sigma}{sup +}({nu}=0,1){yields}X{sup 2}{Pi}({Delta}{nu}=1) at 287 nm, O I transitions 3p{sup 5}P{yields}3s{sup 5}S{sup 0} at 777.41 nm, and 3p{sup 3}P{yields}3s{sup 3}S{sup 0} at 844.6 nm, N{sub 2}(C-B) second positive system with electronic transition C{sup 3}{Pi}{sub u}{sup {yields}}B{sup 3}{Pi}{sub g}'' in the range of 300-450 nm and N{sub 2}{sup +}(B-X) first negative system with electronic transition B{sup 2}{Sigma}{sub u}{sup +}{yields}X{sup 2}{Sigma}{sub g}{sup +}({Delta}{nu}=0) at 391.4 nm have been studied. The atomic emission lines of helium were identified, including the He I transitions 3p{sup 3}P{sup 0}{yields}2s{sup 3}S at 388.8 nm, 3p{sup 1}P{sup 0}{yields} 2s{sup 1}S at 501.6 nm, 3d{sup 3}D{yields}2p{sup 3}P{sup 0} at 587.6 nm, 3d{sup 1}D{yields}2p{sup 1}P{sup 0} at 667.8 nm, 3s{sup 3}S{sup 1}{yields}2p{sup 3}P{sup 0} at 706.5 nm, 3s{sup 1}S{sup 0}{yields}2p{sup 1}P{sup 0} at 728.1 nm, and H{sub {alpha}} transition 2p-3d at 656.3 nm. Using a spectral fitting method, the OH radicals at 306-312 nm, the rotational and vibrational temperatures equivalent to gas temperatures of the discharge was measured and the effective non-equilibrium nature of the plasma jet was demonstrated. Our results show that, in the entire active plasma region, the gas temperature remains at 310 {+-} 25 K and 340 {+-} 25 K and it increases to 320 {+-} 25 K and 360 {+-} 25 K in the afterglow region of the plasma jet for pure helium and helium/oxygen (0.1%) mixture, respectively. Additionally, the vibrational temperatures range from 2200 {+-} 100 K and 2500 {+-} 100 K for pure helium and helium/oxygen (0.1%) mixture, respectively. The plasma jet was tested on heat sensitive polymer films used in biomedical applications such as polyethylene terephthalate and poly-L-lactide samples continuously for several minutes without causing any physical or thermal damage to the films. The plasma jet produces significant reactive species of interest while the gas temperatures remain very low demonstrating its potential for a range of biomedical applications.« less

Absolute band intensities in the nu19/nu23 (530 cm(-1)) and nu7 (777 cm(-1)) bands of acetone ((CH3)2CO) from 232 to 295 K

NASA Technical Reports Server (NTRS)

Wang, W. F.; Stevenson, A.; Reuter, D. C.; Sirota, J. M.

2000-01-01

Absolute band intensities of acetone ((CH3)2CO) in the nu19/nu23 and nu7 band systems near 530 and 777 cm(-1), respectively, were measured at temperatures of 232, 262 and 295 K, using a Fourier transform infrared (FTIR) spectrometer. No evident temperature dependence for the band intensities was observed. The dipole moments and the fundamental band intensities were derived in the harmonic oscillator approximation. The results are useful for the spectroscopic retrieval of acetone concentrations in the upper atmosphere.

Design and synthesis of new adamantyl-substituted antileishmanial ether phospholipids.

PubMed

Papanastasiou, Ioannis; Prousis, Kyriakos C; Georgikopoulou, Kalliopi; Pavlidis, Theofilos; Scoulica, Effie; Kolocouris, Nicolas; Calogeropoulou, Theodora

2010-09-15

A series of new 2-[3-(2-alkyloxy-ethyl)-adamantan-1-yl]-ethoxy substituted ether phospholipids was synthesized and their antileishmanial activity was evaluated against Leishmania infantum amastigotes. The majority of the new analogues were significantly less cytotoxic than miltefosine while, antiparasitic activity depended on the length of the 2-alkyloxy substituent. The most potent compounds were {2-[[[3-(2-hexyloxy-ethyl)-adamant-1-yl]-ethoxy]hydroxyphosphinyloxy]ethyl}-Nu,Nu,Nu-trimethyl-ammonium inner salt (5b) and {2-[[[3-(2-octyloxy-ethyl)-adamant-1-yl]-ethoxy]hydroxyphosphinyloxy]ethyl}-Nu,Nu,Nu-trimethyl-ammonium inner salt (5c). Copyright (c) 2010 Elsevier Ltd. All rights reserved.

The capability of the existing network of installations for detecting the antineutrino burst from collapsing stars

NASA Technical Reports Server (NTRS)

Khalchukov, F. F.; Ryassny, V. G.; Ryazhskaya, O. G.; Zatsepin, G. T.

1985-01-01

As the neutrino fluxes can bring information from the internal layers of the collapsing star, the problem of the neutrino burst detection is of importance for both the direct registering of the collapse itself and the investigation of its dynamics. The main characteristics of the neutrino fluxes have been obtained by simulations. The total neutrino flux energy is estimated as 2.5 x 10 to the 53 to 1.4 x 10 to the 54 erg, the energy of NU sub E flux being 10 to the 53 erg. Predictions on neutrino energy spectra are quite different. Two models of the collapse will be used: the model by Bowers and Wilson, hereafter BW, and the model by Nadyozhin and Otroschenko (NO). The NU sub e spectrum in the BW-model reaches the maximum at E max sub NU = 8 MeV. Average energy of NU sub E E sub nu approx. = 10 MeV. The NO-model gives E max sub Nu = 10.5 MeV and E sub nu = 12.6 MeV. The NU sub E-burst duration is DELTA tau sub NU = 20s for the NO-model. As the black hole formation is the result of the star collapse in the BW-model, DELTA tau sub nu is taken to be 5s.

Torsional Splitting in the Degenerate Vibrational States of (70)Ge(2)H(6): Rotation-Torsion Analysis of the nu(7) and nu(9) Fundamentals.

PubMed

Lattanzi; di Lauro C; Bürger; Mkadmi

2000-09-01

The rotational and torsional structure of the nu(7) and nu(9) degenerate fundamentals of (70)Ge(2)H(6) has been analyzed under high resolution. The torsional structure of both v(7) = 1 and v(9) = 1 states can be fitted by a simple one-parameter formula. The x,y-Coriolis interaction with the parallel nu(5) fundamental was accounted for in the analysis of nu(7). A strong perturbation of the J structure of the E(3s) torsional component of the KDeltaK = -2 subbranches of nu(9) can be explained by the resonance with an E(3s) excited level of the pure torsional manifold. The perturber is centered at 361.58 cm(-1), very close to the value estimated with a barrier height of 285 cm(-1). This confirms that the fundamental torsional wavenumber is close to 103 cm(-1), in good agreement with the "ab initio" prediction. The torsional splittings of all the infrared active degenerate fundamentals, nu(7), nu(8), and nu(9), follow the trend predicted by theory, and have been fitted by exploratory calculations accounting only for the torsional Coriolis-coupling mechanism of all degenerate vibrational fundamentals in several torsional states. This confirms that torsional Coriolis coupling is the dominant mechanism responsible for the decrease of the torsional splitting in the degenerate vibrational states. A higher value of the barrier had to be used for the nu(9) mode. Copyright 2000 Academic Press.

Alterations of Cloud Microphysics Due to Cloud Processed CCN

NASA Astrophysics Data System (ADS)

Hudson, J. G.; Tabor, S. S.; Noble, S. R., Jr.

2015-12-01

High-resolution CCN spectra have revealed bimodality (Hudson et al. 2015) similar to aerosol size spectra (e.g., Hoppel et al. 1985). Bimodality is caused by chemical and physical cloud processes that increase mass or hygroscopicity of only CCN that produced activated cloud droplets. Bimodality is categorized by relative CCN concentrations (NCCN) within the two modes, Nu-Np; i.e., NCCN within the higher critical supersaturation, Sc, mode that did not undergo cloud processing minus NCCN within the lower Sc mode that was cloud processed. Lower, especially negative, Nu-Np designates greater processing. The table shows regressions between Nu-Np and characteristics of clouds nearest the CCN measurements. ICE-T MASE parameter R SL R SL Nc 0.17 93.24 -0.26 98.65 MD -0.31 99.69 0.33 99.78 σ -0.27 99.04 0.48 100.00 Ld -0.31 99.61 0.38 99.96 Table. Correlation coefficients, R, and one-tailed significance levels in percent, SL, for Nu-Np with microphysics of the clouds closest to each CCN measurement, 75 ICE-T and 74 MASE cases. Nc is cloud droplet concentration, MD is cloud droplet mean diameter, σ is standard deviation of cloud droplet spectra, Ldis drizzle drop LWC. Two aircraft field campaigns, Ice in Clouds Experiment-Tropical (ICE-T) and Marine Stratus/Stratocumulus Experiment (MASE) show opposite R signs because coalescence dominated cloud processing in low altitude ICE-T cumuli whereas chemical transformations predominated in MASE low altitude polluted stratus. Coalescence reduces Nc and NCCN, which thus increases MD, and σ, which promote Ld. Chemical transformations, e.g., SO2 to SO4, increase CCN hygroscopicity, thus reducing Sc, but not affecting Nc or NCCN. Lower Sc CCN are capable of producing greater Nc in subsequent cloud cycles, which leads to lower MD and σ which reduce Ld (figure). These observations are consistent with cloud droplet growth models for the higher vertical wind (W) of cumuli and lower W of stratus. Coalescence thus reduces the indirect aerosol effect (IAE) with a positive feedback that further enhances coalescence and drizzle. Chemical cloud processing enhances both components of IAE; 1st IAE by greater droplet surface area, 2ndIAE by suppressing drizzle and thus increasing cloudiness. Hoppel, Fitzgerald and Larson: JGR 90, 2365-79 Hudson, Noble and Tabor: JGRA 120, 3436-52

Probing neutrino mass hierarchy by comparing the charged-current and neutral-current interaction rates of supernova neutrinos

NASA Astrophysics Data System (ADS)

Lai, Kwang-Chang; Lee, Fei-Fan; Lee, Feng-Shiuh; Lin, Guey-Lin; Liu, Tsung-Che; Yang, Yi

2016-07-01

The neutrino mass hierarchy is one of the neutrino fundamental properties yet to be determined. We introduce a method to determine neutrino mass hierarchy by comparing the interaction rate of neutral current (NC) interactions, ν(bar nu) + p → ν(bar nu) + p, and inverse beta decays (IBD), bar nue + p → n + e+, of supernova neutrinos in scintillation detectors. Neutrino flavor conversions inside the supernova are sensitive to neutrino mass hierarchy. Due to Mikheyev-Smirnov-Wolfenstein effects, the full swapping of bar nue flux with the bar nux (x = μ, τ) one occurs in the inverted hierarchy, while such a swapping does not occur in the normal hierarchy. As a result, more high energy IBD events occur in the detector for the inverted hierarchy than the high energy IBD events in the normal hierarchy. By comparing IBD interaction rate with the mass hierarchy independent NC interaction rate, one can determine the neutrino mass hierarchy.

Insight into the Local Solvent Environment of Biologically Relevant Iron-nitroysl Systems through Two-Dimensional Infrared Spectroscopy

NASA Astrophysics Data System (ADS)

Brookes, Jennifer Faith

Iron-nitrosyl systems, particularly in the form of heme proteins, with their iron metal active sites play an important role in biological systems. Heme proteins act as storage, transporters, and receptors for nitric oxide (NO), a signaling molecule that is important in immune, nervous, and cardiovascular systems of mammals. By better understanding the local environment of the active site of NO binding heme proteins we can gain insight into disease in which the NO pathways have been implicated. This is an important step to being able to develop pharmaceuticals targeting NO pathways in humans. Sodium nitroprusside ((SNP, Na2[Fe(CN)5is NO]·2H 2O) investigated as a model system for the active site of nitric oxide binding heme proteins. Using two-dimensional infrared spectroscopy (2D IR) to obtain dephasing dynamics of the nitrosyl stretch (nuNO) in a series of solvents we are able to better understand the local environment of the more complicated metalloproteins. Rigorous line shape analysis is performed by using nonlinear response theory to simulate 2D IR spectra which are then fit to experimental data in an iterative process to extract frequency-frequency correlation functions (FFCFs). The time scales obtained are then correlated to empirical solvent polarity parameters. The analysis of the 2D IR lineshapes reveal that the spectral diffusion timescale of the nuNO in SNP varies from 0.8 -- 4 ps and is negatively correlated with the empirical solvent polarity scales. We continue to investigate NO binding of metalloproteins through 2D IR experiments on nitrophorin 4 (NP4). NP4 is a pH-sensitive NO transporter protein present in the salivary gland of the blood sucking insect Rhodius prolixus which undergoes a pH sensitive structural change between a closed and open conformation allowing for the storage and delivery of NO. The two structures are observed spectroscopically as two distinct pH-dependent nu NO frequencies at ~1904 and ~1917 cm-1. We obtain FFCFs by globally fitting experimental 2D IR spectra to signals calculated using a third-order nonlinear response formalism. The open conformation has frequency-frequency correlation timescales of ~1 ps and ~100 ps under both acidic and basic conditions. The closed conformer has pH dependence with fast time scales of 3.0 ps (pH 5.1) and 1.4 ps (pH 7.9) with a static component present under both conditions. The dephasing dynamics of NP4 can be correlated to the local solvent environment within the distal pocket providing quantitative confirmation to the presence and absence of water molecules in two conformers under both pH conditions.

Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.

PubMed

Hardcastle, Ian R; Liu, Junfeng; Valeur, Eric; Watson, Anna; Ahmed, Shafiq U; Blackburn, Timothy J; Bennaceur, Karim; Clegg, William; Drummond, Catherine; Endicott, Jane A; Golding, Bernard T; Griffin, Roger J; Gruber, Jan; Haggerty, Karen; Harrington, Ross W; Hutton, Claire; Kemp, Stuart; Lu, Xiaohong; McDonnell, James M; Newell, David R; Noble, Martin E M; Payne, Sara L; Revill, Charlotte H; Riedinger, Christiane; Xu, Qing; Lunec, John

2011-03-10

Inhibition of the MDM2-p53 interaction has been shown to produce an antitumor effect, especially in MDM2 amplified tumors. The isoindolinone scaffold has proved to be versatile for the discovery of MDM2-p53 antagonists. Optimization of previously reported inhibitors, for example, NU8231 (7) and NU8165 (49), was guided by MDM2 NMR titrations, which indicated key areas of the binding interaction to be explored. Variation of the 2-N-benzyl and 3-alkoxy substituents resulted in the identification of 3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-nitrobenzyl)isoindolin-1-one (74) as a potent MDM2-p53 inhibitor (IC(50) = 0.23 ± 0.01 μM). Resolution of the enantiomers of 74 showed that potent MDM2-p53 activity primarily resided with the (+)-R-enantiomer (74a; IC(50) = 0.17 ± 0.02 μM). The cellular activity of key compounds has been examined in cell lines with defined p53 and MDM2 status. Compound 74a activates p53, MDM2, and p21 transcription in MDM2 amplified cells and shows moderate selectivity for wild-type p53 cell lines in growth inhibition assays.

Combined quantum mechanical and molecular mechanical method for metal-organic frameworks: proton topologies of NU-1000.

PubMed

Wu, Xin-Ping; Gagliardi, Laura; Truhlar, Donald G

2018-01-17

Metal-organic frameworks (MOFs) are materials with applications in catalysis, gas separations, and storage. Quantum mechanical (QM) calculations can provide valuable guidance to understand and predict their properties. In order to make the calculations faster, rather than modeling these materials as periodic (infinite) systems, it is useful to construct finite models (called cluster models) and use subsystem methods such as fragment methods or combined quantum mechanical and molecular mechanical (QM/MM) methods. Here we employ a QM/MM methodology to study one particular MOF that has been of widespread interest because of its wide pores and good solvent and thermal stability, namely NU-1000, which contains hexanuclear zirconium nodes and 1,3,6,8-tetrakis(p-benzoic acid)pyrene (TBAPy 4- ) linkers. A modified version of the Bristow-Tiana-Walsh transferable force field has been developed to allow QM/MM calculations on NU-1000; we call the new parametrization the NU1T force field. We consider isomeric structures corresponding to various proton topologies of the [Zr 6 (μ 3 -O) 8 O 8 H 16 ] 8+ node of NU-1000, and we compute their relative energies using a QM/MM scheme designed for the present kind of problem. We compared the results to full quantum mechanical (QM) energy calculations and found that the QM/MM models can reproduce the full QM relative energetics (which span a range of 334 kJ mol -1 ) with a mean unsigned deviation (MUD) of only 2 kJ mol -1 . Furthermore, we found that the structures optimized by QM/MM are nearly identical to their full QM optimized counterparts.

Observing the Sun with NuSTAR

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2016-07-01

The Nuclear Spectroscopic Telescope Array (NuSTAR) is a space telescope primarily designed to detect high-energy X-rays from faint, distant astrophysical sources. Recently, however, its occasionally been pointing much closer to home, with the goal of solving a few longstanding mysteries about the Sun.Intensity maps from an observation of a quiet-Sun region near the north solar pole and an active region just below the solar limb. The quiet-Sun data will be searched for small flares that could be heating the solar corona, and the high-altitude emission above the limb may provide clues about particle acceleration. [Adapted from Grefenstette et al. 2016]An Unexpected TargetThough we have a small fleet of space telescopes designed to observe the Sun, theres an important gap: until recently, there was no focusing telescope making solar observations in the hard X-ray band (above ~3 keV). Conveniently, there is a tool capable of doing this: NuSTAR.Though NuSTARs primary mission is to observe faint astrophysical X-ray sources, a team of scientists has recently conducted a series of observations in which NuSTAR was temporarily repurposed and turned to focus on the Sun instead.These observations pose an interesting challenge precisely because of NuSTARs extreme sensitivity: pointing at such a nearby, bright source can quickly swamp the detectors. But though the instrument cant be used to observe the bright flares and outbursts from the Sun, its the perfect tool for examining the parts of the Sun weve been unable to explore in hard X-rays before now such as faint flares, or the quiet, inactive solar surface.In a recently published study led by Brian Grefenstette (California Institute of Technology), the team describes the purpose and initial results of NuSTARs first observations of the Sun.Solar MysteriesWhat is NuSTAR hoping to accomplish with its solar observations? There are two main questions that hard X-ray observations may help to answer.How are particles accelerated in solar flares?The process of electron acceleration during solar flares is not well understood. When a flare-producing active region is occulted by the solar limb, NuSTAR will able to directly observe the flare loop above the solar surface which is where that acceleration is thought to happen.How is the solar corona heated?The solar corona is a toasty 13 million Kelvin significantly warmer than the ~6000 K solar photosphere. So how is the corona heated? One proposed explanation is that the Suns surface constantly emits tiny nanoflares in active regions, or even in the quiet Sun that are so faint that we havent detected them. But with its high sensitivity, NuSTAR may be able to!The first NuSTAR full-disk mosaic of the Sun. The checkerboard pattern is an artifact of the detectors being hit by particles from active regions outside of the field of view a problem which will be reduced as the Sun enters the upcoming quieter part of the solar cycle. [Adapted from Grefenstette et al. 2016]First ObservationsIn NuSTARs first four observations of the Sun, the team unexpectedly observed a major flare (which unsurprisingly swamped the detectors), watched the emission above an active region that was hidden by the solar limb, stared at a section of quiet Sun near the north solar pole, and composed a full-disk mosaic of the solar surface from 16 12 x 12 tiles.All of these initial observations are currently being carefully analyzed and will be presented in detail in future publications. In the meantime, NuSTAR has demonstrated its effectiveness in detecting faint emission in solar hard X-rays, proving that it will be a powerful tool for heliophysics as well as for astrophysics. We look forward to seeing the future results from this campaign!CitationBrian W. Grefenstette et al 2016 ApJ 826 20. doi:10.3847/0004-637X/826/1/20

Space Telemetry for the Energy Industry

NASA Technical Reports Server (NTRS)

1983-01-01

Space telemetry is the process whereby information acquired in orbit is relayed to Earth. In 1981, Bill Sheen, President of Nu-Tech Industries, Inc., saw a need for a better way of monitoring flow, due to high costs of oil and gas, increasing oil field theft and a mounting requirement for more timely information to speed up accounting procedures. Sheen turned to NASA for assistance which was provided by Kerr Industrial Applications Center (KIAC). The system that emerged from two years of research, now in production at Nu-Tech's Fort Worth Texas facility, is known as the Remote Measurement and Control Network.

Molecular Assays for Determining Mycobacterium leprae Viability in Tissues of Experimentally Infected Mice

PubMed Central

Davis, Grace L.; Ray, Nashone A.; Lahiri, Ramanuj; Gillis, Thomas P.; Krahenbuhl, James L.; Williams, Diana L.; Adams, Linda B.

2013-01-01

Background The inability of Mycobacterium leprae to grow on axenic media has necessitated specialized techniques in order to determine viability of this organism. The purpose of this study was to develop a simple and sensitive molecular assay for determining M. leprae viability directly from infected tissues. Methodology/Principle Findings Two M. leprae-specific quantitative reverse transcription PCR (qRT-PCR) assays based on the expression levels of esxA, encoding the ESAT-6 protein, and hsp18, encoding the heat shock 18 kDa protein, were developed and tested using infected footpad (FP) tissues of both immunocompetent and immunocompromised (athymic nu/nu) mice. In addition, the ability of these assays to detect the effects of anti-leprosy drug treatment on M. leprae viability was determined using rifampin and rifapentine, each at 10 mg/kg for 1, 5, or 20 daily doses, in the athymic nu/nu FP model. Molecular enumeration (RLEP PCR) and viability determinations (qRT-PCR) were performed via Taqman methodology on DNA and RNA, respectively, purified from ethanol-fixed FP tissue and compared with conventional enumeration (microscopic counting of acid fast bacilli) and viability assays (radiorespirometry, viability staining) which utilized bacilli freshly harvested from the contralateral FP. Both molecular and conventional assays demonstrated growth and high viability of M. leprae in nu/nu FPs over a 4 month infection period. In contrast, viability was markedly decreased by 8 weeks in immunocompetent mice. Rifapentine significantly reduced bacterial viability after 5 treatments, whereas rifampin required up to 20 treatments for the same efficacy. Neither drug was effective after a single treatment. In addition, host gene expression was monitored with the same RNA preparations. Conclusions hsp18 and esxA qRT-PCR are sensitive molecular indicators, reliably detecting viability of M. leprae in tissues without the need for bacterial isolation or immediate processing, making these assays applicable for in vivo drug screening and promising for clinical and field applications. PMID:24179562

Molecular assays for determining Mycobacterium leprae viability in tissues of experimentally infected mice.

PubMed

Davis, Grace L; Ray, Nashone A; Lahiri, Ramanuj; Gillis, Thomas P; Krahenbuhl, James L; Williams, Diana L; Adams, Linda B

2013-01-01

The inability of Mycobacterium leprae to grow on axenic media has necessitated specialized techniques in order to determine viability of this organism. The purpose of this study was to develop a simple and sensitive molecular assay for determining M. leprae viability directly from infected tissues. Two M. leprae-specific quantitative reverse transcription PCR (qRT-PCR) assays based on the expression levels of esxA, encoding the ESAT-6 protein, and hsp18, encoding the heat shock 18 kDa protein, were developed and tested using infected footpad (FP) tissues of both immunocompetent and immunocompromised (athymic nu/nu) mice. In addition, the ability of these assays to detect the effects of anti-leprosy drug treatment on M. leprae viability was determined using rifampin and rifapentine, each at 10 mg/kg for 1, 5, or 20 daily doses, in the athymic nu/nu FP model. Molecular enumeration (RLEP PCR) and viability determinations (qRT-PCR) were performed via Taqman methodology on DNA and RNA, respectively, purified from ethanol-fixed FP tissue and compared with conventional enumeration (microscopic counting of acid fast bacilli) and viability assays (radiorespirometry, viability staining) which utilized bacilli freshly harvested from the contralateral FP. Both molecular and conventional assays demonstrated growth and high viability of M. leprae in nu/nu FPs over a 4 month infection period. In contrast, viability was markedly decreased by 8 weeks in immunocompetent mice. Rifapentine significantly reduced bacterial viability after 5 treatments, whereas rifampin required up to 20 treatments for the same efficacy. Neither drug was effective after a single treatment. In addition, host gene expression was monitored with the same RNA preparations. hsp18 and esxA qRT-PCR are sensitive molecular indicators, reliably detecting viability of M. leprae in tissues without the need for bacterial isolation or immediate processing, making these assays applicable for in vivo drug screening and promising for clinical and field applications.

Study of the semileptonic charm decays D(0)-->pi(-)l(+)nu and D(0)-->K(-)l(+)nu.

PubMed

Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shibata, E I; Shipsey, I P J; Adams, G S; Chasse, M; Cummings, J P; Danko, I; Napolitano, J; Cronin-Hennessy, D; Park, C S; Park, W; Thayer, J B; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Stroynowski, R; Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dambasuren, E; Dorjkhaidav, O; Menaa, N; Mountain, R; Muramatsu, H; Nandakumar, R; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Mahmood, A H; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Bornheim, A; Lipeles, E; Pappas, S P; Weinstein, A J; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Pedlar, T K; Peterson, D; Pivarski, J; Riley, D; Rosner, J L; Ryd, A; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Sun, W M; Thayer, J G; Urner, D; Wilksen, T; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Wiss, J; Edwards, K W; Besson, D; Gao, K Y; Gong, D T; Kubota, Y; Li, S Z; Poling, R; Scott, A W; Smith, A; Stepaniak, C J; Urheim, J; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Arms, K; Gan, K K; Severini, H; Skubic, P; Asner, D M; Dytman, S A; Mehrabyan, S; Mueller, J A; Savinov, V; Li, Z; Lopez, A; Mendez, H; Ramirez, J

2005-01-14

We investigate the decays D(0)-->pi(-)l(+)nu and D(0)-->K(-)l(+)nu, where l is e or mu, using approximately 7 fb(-1) of data collected with the CLEO III detector. We find R(0) identical with B(D(0)-->pi(-)e(+)nu)/B(D(0)-->K(-)e(+)nu)=0.082+/-0.006+/-0.005. Fits to the kinematic distributions of the data provide parameters describing the form factor of each mode. Combining the form factor results and R(0) gives |f(pi)(+)(0)|(2)|V(cd)|(2)/|f(K)(+)(0)|(2)|V(cs)|(2)=0.038(+0.006+0.005)(-0.007-0.003).

Hard x-ray optics: from HEFT to NuSTAR

NASA Astrophysics Data System (ADS)

Koglin, Jason E.; Chen, C. M. H.; Chonko, Jim C.; Christensen, Finn E.; Craig, William W.; Decker, Todd R.; Hailey, Charles J.; Harrison, Fiona A.; Jensen, Carsten P.; Madsen, Kristin K.; Pivovaroff, Michael J.; Stern, Marcela; Windt, David L.; Ziegler, Eric

2004-10-01

Focusing optics are now poised to dramatically improve the sensitivity and angular resolution at energies above 10 keV to levels that were previously unachievable by the past generation of background limited collimated and coded-aperture instruments. Active balloon programs (HEFT), possible Explorer-class satellites (NuSTAR - currently under Phase A study), and major X-ray observatories (Con-X HXT) using focusing optics will play a major role in future observations of a wide range of objects including young supernova remnants, active galactic nuclei, and galaxy clusters. These instruments call for low cost, grazing incidence optics coated with depth-graded multilayer films that can be nested to achieve large collecting areas. Our approach to building such instruments is to mount segmented mirror shells with our novel error-compensating, monolithic assembly and alignment (EMAAL) procedure. This process involves constraining the mirror segments to successive layers of graphite rods that are precisely machined to the required conic-approximation Wolter-I geometry. We present results of our continued development of thermally formed glass substrates that have been used to build three HEFT telescopes and are proposed for NuSTAR. We demonstrate how our experience in manufacturing complete HEFT telescopes, as well as our experience developing higher performance prototype optics, will lead to the successful production of telescopes that meet the NuSTAR design goals.

Spectral and Temporal Analysis of 1H1934-0617: Observing an “Eclipsed” AGN with XMM-Newton and NuSTAR

NASA Astrophysics Data System (ADS)

Frederick, Sara; Kara, Erin; Reynolds, Christopher S.

2017-01-01

1H1934-0617 is a low-mass (3×106 M⊙) NLS1 which was ranked as 7th in excess variance among AGN comprising the CAIXA catalogue (Ponti 2012). Similar to its high-ranking and oft-studied counterparts, this AGN is extremely time-variable, luminous, and displays strong reflection features. We present spectral and temporal analyses of concurrent XMM-Newton and NuSTAR observations (120 ks), during which we explore a dramatic dip in flux, similar to that of Fairall 9 (Lohfink 2012, 2016). The transit-like dip appears in the NuSTAR band, and the spectral shape of the 0.3-2 keV band remains constant throughout the flux varied observation, ruling out a strong absorber. XMM-Newton’s large effective area and NuSTAR’s constraints on the 10-79 keV band combine to inform us about the source geometry, black hole spin, and emission/absorption processes as we speculate on the nature of the variability of this scarcely-studied AGN. Preliminary spectral modeling indicates that the dip in flux can be understood as a decrease in the height of the corona, and preliminary timing analysis shows hints of an iron K reverberation lag.

A flash photolysis-resonance fluorescence study of the formation of O(D-1) in the photolysis of water and reaction of O(D-1) with H2, Ar and He

NASA Technical Reports Server (NTRS)

Stief, L. J.; Payne, W. A.; Klemm, R. B.

1974-01-01

The relative importance of two primary processes in the photolyis of water: (1) H2O + h (nu) yields H + OH, and (2) H2O + h (nu) yields H2 + OD-1 were determined in a direct manner by time resolved detection (via resonance fluorescence) of H and O formed in processes 1 and 2 respectively. The initially formed OD-1 was deactivated to ground state OP-3 prior to detection via resonance fluorescence. The relative quantum yields for processes 1 and 2 are 0.89 and 0.11 for the wavelength interval 105 to 145nm and = to or greater than 0.99, and = to or less than 0.01 for the wavelength interval 145 to 185nm. Rate constants at 300 K for the reactions OD-1 + H2, + Ar, and + He are presented.

VizieR Online Data Catalog: NuGrid stellar data set I. Yields from H to Bi (Pignatari+, 2016)

NASA Astrophysics Data System (ADS)

Pignatari, M.; Herwig, F.; Hirschi, R.; Bennett, M.; Rockefeller, G.; Fryer, C.; Timmes, F. X.; Ritter, C.; Heger, A.; Jones, S.; Battino, U.; Dotter, A.; Trappitsch, R.; Diehl, S.; Frischknecht, U.; Hungerford, A.; Magkotsios, G.; Travaglio, C.; Young, P.

2016-10-01

We provide a set of stellar evolution and nucleosynthesis calculations that applies established physics assumptions simultaneously to low- and intermediate-mass and massive star models. Our goal is to provide an internally consistent and comprehensive nuclear production and yield database for applications in areas such as presolar grain studies. Our non-rotating models assume convective boundary mixing (CBM) where it has been adopted before. We include 8 (12) initial masses for Z=0.01 (0.02). Models are followed either until the end of the asymptotic giant branch phase or the end of Si burning, complemented by simple analytic core-collapse supernova (SN) models with two options for fallback and shock velocities. The explosions show which pre-SN yields will most strongly be effected by the explosive nucleosynthesis. We discuss how these two explosion parameters impact the light elements and the s and p process. For low- and intermediate-mass models, our stellar yields from H to Bi include the effect of CBM at the He-intershell boundaries and the stellar evolution feedback of the mixing process that produces the 13C pocket. All post-processing nucleosynthesis calculations use the same nuclear reaction rate network and nuclear physics input. We provide a discussion of the nuclear production across the entire mass range organized by element group. The entirety of our stellar nucleosynthesis profile and time evolution output are available electronically, and tools to explore the data on the NuGrid VOspace hosted by the Canadian Astronomical Data Centre are introduced. (12 data files).

NuGrid Stellar Data Set. I.Stellar Yields from H to Bi for Stars with Metallicities Z = 0.02 and Z = 0.01

NASA Astrophysics Data System (ADS)

Pignatari, M.; Herwig, F.; Hirschi, R.; Bennett, M.; Rockefeller, G.; Fryer, C.; Timmes, F. X.; Ritter, C.; Heger, A.; Jones, S.; Battino, U.; Dotter, A.; Trappitsch, R.; Diehl, S.; Frischknecht, U.; Hungerford, A.; Magkotsios, G.; Travaglio, C.; Young, P.

2016-08-01

We provide a set of stellar evolution and nucleosynthesis calculations that applies established physics assumptions simultaneously to low- and intermediate-mass and massive star models. Our goal is to provide an internally consistent and comprehensive nuclear production and yield database for applications in areas such as presolar grain studies. Our non-rotating models assume convective boundary mixing (CBM) where it has been adopted before. We include 8 (12) initial masses for Z = 0.01 (0.02). Models are followed either until the end of the asymptotic giant branch phase or the end of Si burning, complemented by simple analytic core-collapse supernova (SN) models with two options for fallback and shock velocities. The explosions show which pre-SN yields will most strongly be effected by the explosive nucleosynthesis. We discuss how these two explosion parameters impact the light elements and the s and p process. For low- and intermediate-mass models, our stellar yields from H to Bi include the effect of CBM at the He-intershell boundaries and the stellar evolution feedback of the mixing process that produces the {}13{{C}} pocket. All post-processing nucleosynthesis calculations use the same nuclear reaction rate network and nuclear physics input. We provide a discussion of the nuclear production across the entire mass range organized by element group. The entirety of our stellar nucleosynthesis profile and time evolution output are available electronically, and tools to explore the data on the NuGrid VOspace hosted by the Canadian Astronomical Data Centre are introduced.

NEMA NU 4-2008 Comparison of Preclinical PET Imaging Systems

PubMed Central

Goertzen, Andrew L.; Bao, Qinan; Bergeron, Mélanie; Blankemeyer, Eric; Blinder, Stephan; Cañadas, Mario; Chatziioannou, Arion F.; Dinelle, Katherine; Elhami, Esmat; Jans, Hans-Sonke; Lage, Eduardo; Lecomte, Roger; Sossi, Vesna; Surti, Suleman; Tai, Yuan-Chuan; Vaquero, Juan José; Vicente, Esther; Williams, Darin A.; Laforest, Richard

2014-01-01

The National Electrical Manufacturers Association (NEMA) standard NU 4-2008 for performance measurements of small-animal tomographs was recently published. Before this standard, there were no standard testing procedures for preclinical PET systems, and manufacturers could not provide clear specifications similar to those available for clinical systems under NEMA NU 2-1994 and 2-2001. Consequently, performance evaluation papers used methods that were modified ad hoc from the clinical PET NEMA standard, thus making comparisons between systems difficult. Methods We acquired NEMA NU 4-2008 performance data for a collection of commercial animal PET systems manufactured since 2000: micro- PET P4, microPET R4, microPET Focus 120, microPET Focus 220, Inveon, ClearPET, Mosaic HP, Argus (formerly eXplore Vista), VrPET, LabPET 8, and LabPET 12. The data included spatial resolution, counting-rate performance, scatter fraction, sensitivity, and image quality and were acquired using settings for routine PET. Results The data showed a steady improvement in system performance for newer systems as compared with first-generation systems, with notable improvements in spatial resolution and sensitivity. Conclusion Variation in system design makes direct comparisons between systems from different vendors difficult. When considering the results from NEMA testing, one must also consider the suitability of the PET system for the specific imaging task at hand. PMID:22699999

Oxidative and nutrient stability of a standard rodent spaceflight diet during long-term storage.

PubMed

Sun, Gwo-Shing; Tou, Janet C; Reiss-Bubenheim, Debra A; Hill, Esther L; Liittschwager, Kurt W; Girten, Beverly E; Pena-Yewkukhiw, Eugenia

2012-09-01

The National Aeronautics and Space Administration's standard spaceflight diet for rodents is the nutrient-upgraded rodent food bar (NuRFB). The shelf life of the NuRFB needs to be determined in order to avoid malnutrition of rodents and confounding of research results resulting from nutritional deficiency. The authors compared the oxidative and nutrient stability of NuRFBs stored at either ambient temperature (26 °C) or at refrigeration temperature (4 °C) for use in long-term rodent feeding experiments. After 0, 3, 6, 9 and 12 months (mo) of storage, lipid oxidation, fatty acid composition and amounts of specific vitamins and amino acids in NuRFBs were analyzed. No oxidative rancidity developed in NuRFBs stored at 4 °C for up to 12 mo, but NuRFBs stored at 26 °C for 6 mo developed oxidative rancidity and had reduced amounts of γ-linolenic acid (18:3n-6). Despite loss of vitamin E, vitamin A and thiamin after storage at 26 °C for 12 mo, vitamin levels in NuRFBs remained at or above the levels recommended for optimal rodent health. The amino acid profile of NuRFBs was unaffected by storage at 4 °C or 26 °C for 12 mo. The results suggest that NuRFBs stored at 4 °C for up to 12 mo and NuRFBs stored at 26 °C for up to 6 mo provide suitable nutrition for rodents in long-term experiments.

Presidential Green Chemistry Challenge: 2006 Small Business Award

EPA Pesticide Factsheets

Presidential Green Chemistry Challenge 2006 award winners, Arkon Consultants and NuPro Technologies, developed a safer processing system for flexographic printing that includes washout solvents and reclamation/recycling.

NuA4 Lysine Acetyltransferase Complex Contributes to Phospholipid Homeostasis in Saccharomyces cerevisiae.

PubMed

Dacquay, Louis; Flint, Annika; Butcher, James; Salem, Danny; Kennedy, Michael; Kaern, Mads; Stintzi, Alain; Baetz, Kristin

2017-06-07

Actively proliferating cells constantly monitor and readjust their metabolic pathways to ensure the replenishment of phospholipids necessary for membrane biogenesis and intracellular trafficking. In Saccharomyces cerevisiae , multiple studies have suggested that the lysine acetyltransferase complex NuA4 plays a role in phospholipid homeostasis. For one, NuA4 mutants induce the expression of the inositol-3-phosphate synthase gene, INO1 , which leads to excessive accumulation of inositol, a key metabolite used for phospholipid biosynthesis. Additionally, NuA4 mutants also display negative genetic interactions with sec14-1 ts , a mutant of a lipid-binding gene responsible for phospholipid remodeling of the Golgi. Here, using a combination of genetics and transcriptional profiling, we explore the connections between NuA4, inositol, and Sec14 Surprisingly, we found that NuA4 mutants did not suppress but rather exacerbated the growth defects of sec14-1 ts under inositol-depleted conditions. Transcriptome studies reveal that while loss of the NuA4 subunit EAF1 in sec14-1 ts does derepress INO1 expression, it does not derepress all inositol/choline-responsive phospholipid genes, suggesting that the impact of Eaf1 on phospholipid homeostasis extends beyond inositol biosynthesis. In fact, we find that NuA4 mutants have impaired lipid droplet levels and through genetic and chemical approaches, we determine that the genetic interaction between sec14-1 ts and NuA4 mutants potentially reflects a role for NuA4 in fatty acid biosynthesis. Altogether, our work identifies a new role for NuA4 in phospholipid homeostasis. Copyright © 2017 Dacquay et al.

Determination of the Michel parameters and the {tau} neutrino helicity in {tau} decay

DOE Office of Scientific and Technical Information (OSTI.GOV)

CLEO Collaboration

1997-11-01

Using the CLEO II detector at the Cornell Electron Storage Ring operated at {radical} (s) =10.6GeV, we have determined the Michel parameters {rho}, {xi}, and {delta} in {tau}{sup {minus_plus}}{r_arrow}l{sup {minus_plus}}{nu}{bar {nu}} decay as well as the {tau} neutrino helicity parameter h{sub {nu}{sub {tau}}} in {tau}{sup {minus_plus}}{r_arrow}{pi}{sup {minus_plus}}{pi}{sup 0}{nu} decay. From a data sample of 3.02{times}10{sup 6} produced {tau} pairs we analyzed events of the topologies e{sup +}e{sup {minus}}{r_arrow}{tau}{sup +}{tau}{sup {minus}}{r_arrow}(l{sup {plus_minus}}{nu}{bar {nu}})({pi}{sup {minus_plus}}{pi}{sup 0}{nu}) and e{sup +}e{sup {minus}}{r_arrow}{tau}{sup +}{tau}{sup {minus}}{r_arrow}({pi}{sup {plus_minus}}{pi}{sup 0}{bar {nu}})({pi}{sup {minus_plus}}{pi}{sup 0}{nu}). We obtain {rho}=0.747{rho}=0.747{plus_minus}0.010{plus_minus}0.006, {xi}=1.007{plus_minus}0.040{plus_minus}0.015, {xi}{delta}=0.745{plus_minus}0.026{plus_minus}0.009, and h{sub {nu}{sub {tau}}}={minus}0.995{plus_minus}0.010{plus_minus}0.003, where we have used the previouslymore » determined sign of h{sub {nu}{sub {tau}}} [ARGUS Collaboration, H. Albrecht {ital et al.}, Z. Phys. C {bold 58}, 61 (1993); Phys. Lett. B {bold 349}, 576 (1995)]. We also present the Michel parameters as determined from the electron and muon samples separately. All results are in agreement with the standard model V{minus}A interaction. {copyright} {ital 1997} {ital The American Physical Society}« less

Crossed beam (E--VRT) energy transfer experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hertel, I.V.; Hofmann, H.; Rost, K.A.

A molecular crossed beam apparatus which has been developed to perform electronic-to-vibrational, rotational, translational (E--V,R,T) energy transfer studies is described. Its capabilities are illustrated on the basis of a number of energy transfer spectra obtained for collision systems of the type Na*+Mol(..nu..,j) ..-->..Na+Mol (..nu..',j') where Na* represents a laser excited sodium atom and Mol a diatomic or polyatomic molecule. Because of the lack of reliable dynamic theories on quenching processes, statistical approaches such as the ''linearly forced harmonic oscillator'' and ''prior distributions'' have been used to model the experimental spectra. The agreement is found to be satisfactory, so even suchmore » simple statistics may be useful to describe (E--V,R,T) energy transfer processes in collision systems with small molecules.« less

Study of B to pi l nu and B to rho l nu Decays and Determination of |V_ub|

DOE Office of Scientific and Technical Information (OSTI.GOV)

del Amo Sanchez, P.; Lees, J.P.; Poireau, V.

2011-12-09

We present an analysis of exclusive charmless semileptonic B-meson decays based on 377 million B{bar B} pairs recorded with the BABAR detector at the {Upsilon} (4S) resonance. We select four event samples corresponding to the decay modes B{sup 0} {yields} {pi}{sup -}{ell}{sup +}{nu}, B{sup +} {yields} {pi}{sup 0}{ell}{sup +}{nu}, B{sup 0} {yields} {rho}{sup -}{ell}{sup +}{nu}, and B{sup +} {yields} {rho}{sup 0}{ell}{sup +}{nu}, and find the measured branching fractions to be consistent with isospin symmetry. Assuming isospin symmetry, we combine the two B {yields} {pi}{ell}{nu} samples, and similarly the two B {yields} {rho}{ell}{nu} samples, and measure the branching fractions {Beta}(B{sup 0}more » {yields} {pi}{sup -}{ell}{sup +}{nu}) = (1.41 {+-} 0.05 {+-} 0.07) x 10{sup -4} and {Beta}(B{sup 0} {yields} {rho}{sup 0}{ell}{sup +}{nu}) = (1.75 {+-} 0.15 {+-} 0.27) x 10{sup -4}, where the errors are statistical and systematic. We compare the measured distribution in q{sup 2}, the momentum transfer squared, with predictions for the form factors from QCD calculations and determine the CKM matrix element |V{sub ub}|. Based on the measured partial branching fraction for B {yields} {pi}{ell}{nu} in the range q{sup 2} < 12 GeV{sup 2} and the most recent LCSR calculations we obtain |V{sub ub}| = (3.78 {+-} 0.13{sub -0.40}{sup +0.55}) x 10{sup -3}, where the errors refer to the experimental and theoretical uncertainties. From a simultaneous fit to the data over the full q{sup 2} range and the FNAL/MILC lattice QCD results, we obtain |V{sub ub}| = (2.95 {+-} 0.31) x 10{sup -3} from B {yields} {pi}{ell}{nu}, where the error is the combined experimental and theoretical uncertainty.« less

Finite field equation of Yang--Mills theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandt, R.A.; Wing-Chiu, N.; Yeung, W.

1980-03-01

We consider the finite local field equation -)(1+1/..cap alpha.. (1+f/sub 4/))g/sup munu/D'Alembertian-partial/sup ..mu../partial/sup ..nu../)A/sup nua/ =-(1+f/sub 3/) g/sup 2/N(A/sup c/..nu..A/sup a/..mu..A/sub ..nu..//sup c/) +xxx+(1-s)/sup 2/M/sup 2/A/sup a/..mu.., introduced by Lowenstein to rigorously describe SU(2) Yang--Mills theory, which is written in terms of normal products. We also consider the operator product expansion A/sup c/..nu..(x+xi) A/sup a/..mu..(x) A/sup b/lambda(x-xi) approx...sigma..M/sup c/ab..nu mu..lambda/sub c/'a'b'..nu..'..mu..'lambda' (xi) N(A/sup nuprimec/'A/sup muprimea/'A/sup lambdaprimeb/')(x), and using asymptotic freedom, we compute the leading behavior of the Wilson coefficients M/sup ...//sub .../(xi) with the help of a computer, and express the normal products in the field equation in terms ofmore » products of the c-number Wilson coefficients and of operator products like A/sup c/..nu..(x+xi) A/sup a/..mu..(x) A/sup b/lambda(x-xi) at separated points. Our result is -)(1+(1/..cap alpha..)(1+f/sub 4/))g/sup munu/D'Alembertian-partial/sup ..mu../partial/sup ..nu../)A/sup nua/ =-(1+f/sub 3/) g/sup 2/lim/sub xiarrow-right0/) (lnxi)/sup -0.28/2b/(A/sup c/..nu.. (x+xi) A/sup a/..mu..(x) A/sub ..nu..//sup c/(x-xi) +epsilon/sup a/bcA/sup muc/(x+xi) partial/sup ..nu../A/sup b//sub ..nu../(x)+xxx) +xxx)+(1-s)/sup 2/M/sup 2/A/sup a/..mu.., where ..beta.. (g) =-bg/sup 3/, and so (lnxi)/sup -0.28/2b/ is the leading behavior of the c-number coefficient multiplying the operator products in the field equation.« less

Mass Measurements of Proton-Rich Isotopes between Mo and Pd using the Canadian Penning Trap Mass Spectrometer

NASA Astrophysics Data System (ADS)

Fallis, J.; Sharma, K. S.; Sharma, H.; Savard, G.; Levand, A. F.; Sun, T.; Clark, J. A.; Deibel, C.; Parikh, A.; Wrede, C.; Lascar, D.; Segel, R.; Caldwell, S.; Sternberg, M.; van Schelt, J.; Buchinger, F.; Crawford, J. E.; Gulick, S.; Lee, J. K. P.; Li, G.; Scielzo, N. D.; Hecht, A. A.

2008-04-01

In our understanding of the origin of elemental abundances the means of producing the observed abundances of ^92Mo and ^94Mo have long been unknown. These ``light p'' nuclei cannot be adequately produced by the classic p-process alone. The νp-process however, which occurs due to the neutrino wind in core collapse supernovae explosions, involves both proton-capture and neutron-capture reactions and can produce ^92Mo and ^94Mo. The final abundances of these isotopes depend directly on the values of the proton separation energies, Sp, along the reaction path of this process. Recent mass measurements performed with the Canadian Penning Trap Mass Spectrometer have dramatically reduced the uncertainties of Sp values of proton-rich nuclei between Mo and Pd. These measurements and the resulting implications for both the νp-process path and the ^92Mo/^94Mo abundance ratio will be discussed. This work was supported by grants from NSERC, Canada and the U.S. DOE, Nucl. Phys. Div.,under Contract W-31-109-ENG-38

SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Verbakel, Werner, E-mail: werner.verbakel@chem.kuleuven.be; Carmeliet, Geert, E-mail: geert.carmeliet@med.kuleuven.be; Engelborghs, Yves, E-mail: yves.engelborghs@fys.kuleuven.be

2011-08-12

Highlights: {yields} The SAP-like domain in NuSAP is a functional DNA-binding domain with preference for dsDNA. {yields} This SAP-like domain is essential for chromosome loading during early mitosis. {yields} NuSAP is highly dynamic on mitotic chromatin, as evident from photobleaching experiments. {yields} The SAP-like domain also mediates NuSAP-chromatin interaction in interphase nucleoplasm. -- Abstract: Nucleolar spindle associated protein (NuSAP) is a microtubule-stabilizing protein that localizes to chromosome arms and chromosome-proximal microtubules during mitosis and to the nucleus, with enrichment in the nucleoli, during interphase. The critical function of NuSAP is underscored by the finding that its depletion in HeLa cellsmore » results in various mitotic defects. Moreover, NuSAP is found overexpressed in multiple cancers and its expression levels often correlate with the aggressiveness of cancer. Due to its localization on chromosome arms and combination of microtubule-stabilizing and DNA-binding properties, NuSAP takes a special place within the extensive group of spindle assembly factors. In this study, we identify a SAP-like domain that shows DNA binding in vitro with a preference for dsDNA. Deletion of the SAP-like domain abolishes chromosome arm binding of NuSAP during mitosis, but is not sufficient to abrogate its chromosome-proximal localization after anaphase onset. Fluorescence recovery after photobleaching experiments revealed the highly dynamic nature of this NuSAP-chromatin interaction during mitosis. In interphase cells, NuSAP also interacts with chromatin through its SAP-like domain, as evident from its enrichment on dense chromatin regions and intranuclear mobility, measured by fluorescence correlation spectroscopy. The obtained results are in agreement with a model where NuSAP dynamically stabilizes newly formed microtubules on mitotic chromosomes to enhance chromosome positioning without immobilizing these microtubules. Interphase NuSAP-chromatin interaction suggests additional functions for NuSAP, as recently identified for other nuclear spindle assembly factors with a role in gene expression or DNA damage response.« less

Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer.

PubMed

Dhar, Swati; Kumar, Avinash; Li, Kun; Tzivion, Guri; Levenson, Anait S

2015-02-01

Metastasis associated protein 1 (MTA1) is a component of the nucleosome remodeling and deacetylating (NuRD) complex which mediates gene silencing and is overexpressed in several cancers. We reported earlier that resveratrol, a dietary stilbene found in grapes, can down-regulate MTA1. In the present study, we show that PTEN is inactivated by MTA1 in prostate cancer cells. Further, we show that resveratrol promotes acetylation and reactivation of PTEN via inhibition of the MTA1/HDAC complex, resulting in inhibition of the Akt pathway. In addition, we show that MTA1 knockdown is sufficient to augment acetylation of PTEN indicating a crucial role of MTA1 itself in the regulation of PTEN acetylation contributing to its lipid phosphatase activity. Acetylated PTEN preferentially accumulates in the nucleus where it binds to MTA1. We also show that MTA1 interacts exclusively with PTEN acetylated on Lys¹²⁵ and Lys¹²⁸, resulting in diminished p-Akt levels. Finally, using orthotopic prostate cancer xenografts, we demonstrate that both resveratrol treatment and MTA1 knockdown enhance PTEN levels leading to a decreased p-Akt expression and proliferation index. Taken together, our results indicate that MTA1/HDAC unit is a negative regulator of PTEN which facilitates survival pathways and progression of prostate cancer and that resveratrol can reverse this process through its MTA1 inhibitory function. Copyright © 2014 Elsevier B.V. All rights reserved.

The near infrared spectrum of ozone by CW-cavity ring down spectroscopy between 5850 and 7000 cm(-1): new observations and exhaustive review.

PubMed

Campargue, A; Barbe, A; De Backer-Barilly, M-R; Tyuterev, Vl G; Kassi, S

2008-05-28

Weak vibrational bands of (16)O(3) could be detected in the 5850-7030 cm(-1) spectral region by CW-cavity ring down spectroscopy using a set of fibered DFB diode lasers. As a result of the high sensitivity (noise equivalent absorption alpha(min) approximately 3 x 10(-10) cm(-1)), bands reaching a total of 16 upper vibrational states have been previously reported in selected spectral regions. In the present report, the analysis of the whole investigated region is completed by new recordings in three spectral regions which have allowed: (i) a refined analysis of the nu(1) + 3nu(2) + 3nu(3) band from new spectra in the 5850-5900 cm(-1) region; (ii) an important extension of the assignments of the 2nu(1)+5nu(3) and 4nu(1) + 2nu(2) + nu(3) bands in the 6500-6600 cm(-1) region, previously recorded by frequency modulation diode laser spectroscopy. The rovibrational assignments of the weak 4nu(1) + 2nu(2) + nu(3) band were fully confirmed by the new observation of the 4nu(1) + 2nu(2) + nu(3)- nu(2) hot band near 5866.9 cm(-1) reaching the same upper state; (iii) the observation and modelling of three A-type bands at 6895.51, 6981.87 and 6990.07 cm(-1) corresponding to the highest excited vibrational bands of ozone detected so far at high resolution. The upper vibrational states were assigned by comparison of their energy values with calculated values obtained from the ground state potential energy surface of (16)O(3). The vibrational mixing and consequently the ambiguities in the vibrational labelling are discussed. For each band or set of interacting bands, the spectroscopic parameters were determined from a fit of the corresponding line positions in the frame of the effective Hamiltonian (EH) model. A set of selected absolute line intensities was measured and used to derive the parameters of the effective transition moment operator. The exhaustive review of the previous observations gathered with the present results is presented and discussed. It leads to a total number of 3863 energy levels belonging to 21 vibrational states and corresponding to 7315 transitions. In the considered spectral region corresponding to up to 82% of the dissociation energy, the increasing importance of the "dark" states is illustrated by the occurrence of frequent rovibrational perturbations and the observation of many weak lines still unassigned.

Intracellular delivery of peptide cargos using iron oxide based nanoparticles: studies on antitumor efficacy of a BCL-2 converting peptide, NuBCP-9

NASA Astrophysics Data System (ADS)

Kumar, Manoj; Singh, Gurpal; Sharma, Sapna; Gupta, Dikshi; Bansal, Vivek; Arora, Vikas; Bhat, Madhusudan; Srivastava, Sandeep K.; Sapra, Sameer; Kharbanda, Surender; Dinda, Amit K.; Singh, Harpal

2014-11-01

Delivering peptides into cells targeting the undruggable oncoproteins is an emerging area in cancer therapeutics. Here we report a novel nanoparticle-based delivery system that can transport therapeutic cargos to the intracellular sites without the need for a cell transduction or penetration domain (CPP). In the present study, we have used iron oxide nanoparticles to deliver an oncopeptide, NuBCP-9, targeting the BCL-2 BH3 domain. Citric acid/2-bromo 2-methylpropanoic acid (CA/BMPA)-capped SPIONs were used to immobilize and deliver the NuBCP-9 peptide to the cancer cells without any noticeable off-target effects. Our results have demonstrated that NuBCP-9-SPIONs efficiently penetrate into cancer cells and bind to its intracellular target protein BCL-2. Moreover, significant inhibition of proliferation and substantial induction of cell death were observed when cancer cells were treated with NuBCP-9-SPIONs at different time intervals. Importantly, the IC50 values for killing of breast cancer cells with NuBCP-9-SPIONs were much lower compared to cells treated with the NuBCP-9 peptide linked with a CPP (Arg-8; NuBCP-9-R8). Molecular and biochemical analyses further supported that NuBCP-9-SPIONs killed breast cancer cells by apoptosis-mediated mechanisms. Furthermore, our data demonstrated that administration of NuBCP-9-SPIONs to mice bearing Ehrlich ascites tumors (EAT) was associated with loss of tumorigenicity and extensive apoptosis in tumor tissues. Taken together, these findings show that a non-CPP-tagged peptide can be successfully delivered to undruggable intracellular oncotargets using SPIONs.Delivering peptides into cells targeting the undruggable oncoproteins is an emerging area in cancer therapeutics. Here we report a novel nanoparticle-based delivery system that can transport therapeutic cargos to the intracellular sites without the need for a cell transduction or penetration domain (CPP). In the present study, we have used iron oxide nanoparticles to deliver an oncopeptide, NuBCP-9, targeting the BCL-2 BH3 domain. Citric acid/2-bromo 2-methylpropanoic acid (CA/BMPA)-capped SPIONs were used to immobilize and deliver the NuBCP-9 peptide to the cancer cells without any noticeable off-target effects. Our results have demonstrated that NuBCP-9-SPIONs efficiently penetrate into cancer cells and bind to its intracellular target protein BCL-2. Moreover, significant inhibition of proliferation and substantial induction of cell death were observed when cancer cells were treated with NuBCP-9-SPIONs at different time intervals. Importantly, the IC50 values for killing of breast cancer cells with NuBCP-9-SPIONs were much lower compared to cells treated with the NuBCP-9 peptide linked with a CPP (Arg-8; NuBCP-9-R8). Molecular and biochemical analyses further supported that NuBCP-9-SPIONs killed breast cancer cells by apoptosis-mediated mechanisms. Furthermore, our data demonstrated that administration of NuBCP-9-SPIONs to mice bearing Ehrlich ascites tumors (EAT) was associated with loss of tumorigenicity and extensive apoptosis in tumor tissues. Taken together, these findings show that a non-CPP-tagged peptide can be successfully delivered to undruggable intracellular oncotargets using SPIONs. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr04504a

Heart rate and blood pressure variabilities in salt-sensitive hypertension.

PubMed

Piccirillo, G; Bucca, C; Durante, M; Santagada, E; Munizzi, M R; Cacciafesta, M; Marigliano, V

1996-12-01

In salt-sensitive hypertension, a high sodium intake causes plasma catecholamines to rise and pulmonary baroreceptor plasticity to fall. In salt-sensitive and salt-resistant hypertensive subjects during low and high sodium intakes, we studied autonomic nervous system activity by power spectral analysis of heart rate and arterial pressure variabilities and baroreceptor sensitivity. In all subjects, high sodium intake significantly enhanced the low-frequency power of heart rate and arterial pressures at rest and after sympathetic stress. It also increased heart rate and arterial pressure variabilities. During high sodium intake, salt-sensitive hypertensive subjects had significantly higher low-frequency powers of systolic arterial pressure (7.5 mm Hg2, P < .05) and of heart rate at rest (59.2 +/- 2.4 normalized units [NU], P < .001) than salt-resistant subjects (6.6 +/- 0.3 mm Hg2, 55.0 +/- 3.2 NU) and normotensive control subjects (5.1 +/- 0.5 mm Hg2, 41.6 +/- 2.9 NU). In salt-sensitive subjects, low sodium intake significantly reduced low-frequency normalized units (P < .001) and the ratio of low- to high-power frequency (P < .001). High-sodium intake significantly increased baroreflex sensitivity in control subjects (from 10.0 +/- 0.7 to 17.5 +/- 0.7 ms/mm Hg, P < .001) and salt-resistant subjects (from 6.9 +/- 0.7 to 13.9 +/- 0.9, P < .05) but not in salt-sensitive subjects (7.4 +/- 0.3 to 7.9 +/- 0.4). In conclusion, a high sodium intake markedly enhances cardiac sympathetic activity in salt-sensitive and salt-resistant hypertension. In contrast, although reduced sodium intake lowers arterial pressure and sympathetic activity, it does so only in salt-sensitive subjects. Hence, in salt-resistant subjects, neither arterial pressure nor sympathetic activity depends on salt intake. During a high sodium intake in normotensive subjects and salt-resistant hypertensive subjects, increased sympathetic activity is probably compensated by enhanced baroreflex sensitivity.

Process evaluation of the project P.A.T.H.S. (secondary 2 program): findings based on the co-walker scheme.

PubMed

Shek, Daniel T L; Tam, Suet-yan

2009-01-01

To understand the implementation quality of the Tier 1 Program (Secondary 2 Curriculum) of the P.A.T.H.S. Project, process evaluation was carried out by co-walkers through classroom observation of 195 units in 131 schools. Results showed that the overall level of program adherence was generally high with an average of 84.55%, and different factors of the implementation process were evaluated as positive. Quality of program implementation and achievement of program objectives were predicted by students' participation and involvement, strategies to enhance students' motivation, opportunity for reflection, time management, and class preparation. Success in program implementation was predicted by students' participation and involvement, classroom control, interactive delivery method, strategies to enhance students' motivation, opportunity for reflection, and lesson preparation.

Experimental NMR spin-lattice relaxometry study in the liquid crystalline nematic phase of propylcyano-phenylcyclohexane.

PubMed

Acosta, R H; Pusiol, D J

2001-01-01

The NMR spin-lattice proton relaxation dispersion T1(nu(L)) of the liquid crystal propylcyano-phenylcyclohexane is studied over several decades of Larmor frequencies and at different temperatures in the nematic mesophase. The results show that the order fluctuation of the local nematic director contribution to T1(nu(L)) undergoes a transition between two power regimes: from T1(nu(L)) protional to nu(1/2)L to nu(alpha)L (alpha approximately 1/3) on going from low to high Larmor frequencies.

Low-energy spectral features of supernova (anti)neutrinos in inverted hierarchy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fogli, G. L.; Marrone, A.; Tamborra, I.

2008-11-01

In the dense supernova core, self-interactions may align the flavor polarization vectors of {nu} and {nu} and induce collective flavor transformations. Different alignment Ansaetze are known to describe approximately the phenomena of synchronized or bipolar oscillations and the split of {nu} energy spectra. We discuss another phenomenon observed in some numerical experiments in inverted hierarchy, showing features akin to a low-energy split of {nu} spectra. The phenomenon appears to be approximately described by another alignment Ansatz which, in the considered scenario, reduces the (nonadiabatic) dynamics of all energy modes to only two {nu} plus two {nu} modes. The associated spectralmore » features, however, appear to be fragile when passing from single to multiangle simulations.« less

NuSTAR Study of Hard X-ray Morphology and Spectroscopy G21.5-0.9

NASA Technical Reports Server (NTRS)

Nynka, Melania; Hailey, Charles J.; Reynolds, Stephen P.; An, Hongjun; Baganoff, Frederick K.; Boggs, Steven E.; Christensen, Finn E.; Craig, William W.; Gotthelf, Eric V.; Grefenstette, Brian W.;

Laser Frequency Stabilization for Coherent Lidar Applications using Novel All-Fiber Gas Reference Cell Fabrication Technique

NASA Technical Reports Server (NTRS)

Meras, Patrick, Jr.; Poberezhskiy, Ilya Y.; Chang, Daniel H.; Levin, Jason; Spiers, Gary D.

2008-01-01

Compact hollow-core photonic crystal fiber (HC-PCF)gas frequency reference cell was constructed using a novel packaging technique that relies on torch-sealing a quartz filling tube connected to a mechanical splice between regular and hollow-core fibers. The use of this gas cell for laser frequency stabilization was demonstrated by locking a tunable diode laser to the center of the P9 line from the (nu)1+(nu)3 band of acetylene with RMS frequency error of 2.06 MHz over 2 hours. This effort was performed in support of a task to miniaturize the laser frequency stabilization subsystem of JPL/LMCT Laser Absorption Spectrometer (LAS) instrument.

PTF discovers and follows-up nearby, young, Type II supernova

NASA Astrophysics Data System (ADS)

Kasliwal, M. M.; Quimby, R. M.; Ofek, E. O.; Kulkarni, S. R.; Gal-Yam, A.; Arcavi, I.; Green, Y.; Walker, E.; Mazzali, P.; Nugent, P. E.; Poznanski, D.; Howell, D. A.; Dilday, B.; Fox, D. B.

2010-09-01

On UT 2010 Sep 15.243, the Palomar Transient Factory discovered an optical transient, PTF10vdl at RA(J2000) = 23:05:49.001 and DEC(J2000)=03:31:20.50 near NGC 7483. We obtained Target Of Opportunity spectra with Gemini-S/GMOS (PI Kasliwal) on Sep 16.29. The spectrum was extremely blue (f_nu proportional to nu^4.5) and nearly featureless. We further obtained a spectrum with the TNG/DOLORES (PI Walker) on Sep 17.40 and P-Cygni profiles of four Balmer lines were clearly visible, consistent with the redshift of NGC 7483, suggesting this is a Type II supernova.

The NUC and blind pixel eliminating in the DTDI application

NASA Astrophysics Data System (ADS)

Su, Xiao Feng; Chen, Fan Sheng; Pan, Sheng Da; Gong, Xue Yi; Dong, Yu Cui

2013-12-01

AS infrared CMOS Digital TDI (Time Delay and integrate) has a simple structure, excellent performance and flexible operation, it has been used in more and more applications. Because of the limitation of the Production process level, the plane array of the infrared detector has a large NU (non-uniformity) and a certain blind pixel rate. Both of the two will raise the noise and lead to the TDI works not very well. In this paper, for the impact of the system performance, the most important elements are analyzed, which are the NU of the optical system, the NU of the Plane array and the blind pixel in the Plane array. Here a reasonable algorithm which considers the background removal and the linear response model of the infrared detector is used to do the NUC (Non-uniformity correction) process, when the infrared detector array is used as a Digital TDI. In order to eliminate the impact of the blind pixel, the concept of surplus pixel method is introduced in, through the method, the SNR (signal to noise ratio) can be improved and the spatial and temporal resolution will not be changed. Finally we use a MWIR (Medium Ware Infrared) detector to do the experiment and the result proves the effectiveness of the method.

A Proposal for Kelly CriterionBased Lossy Network Compression

DTIC Science & Technology

2016-03-01

warehousing and data mining techniques for cyber security. New York (NY): Springer; 2007. p. 83–108. 34. Münz G, Li S, Carle G. Traffic anomaly...p. 188–196. 48. Kim NU, Park MW, Park SH, Jung SM, Eom JH, Chung TM. A study on ef- fective hash-based load balancing scheme for parallel nids. In

Temperature dependence of vibrational relaxation in the HF, DF, HF-CO2, and DF-CO2 systems

NASA Technical Reports Server (NTRS)

Lucht, R. A.; Cool, T. A.

1974-01-01

The laser excited fluorescence method has been employed to determine rate constants for V to V, R and V to R, T relaxation HF (nu = 1) and DF(nu = 1) by CO2 over the temperature range from 295 to 670 K. The self-deactivation rates for HF(nu = 1) and DF(nu = 1) by ground state molecules and the rate of V to V, R transfer from HF(nu = 1) and DF(nu = 1) to the CO2 (00/0/1) state exhibit a marked decrease with increasing temperature. The results provide additional evidence for the conversion of the large vibrational energy defects of the present systems into rotational motion of the hydrogen halide under the influence of a sizable attractive intermolecular potential well.

Heat-transport enhancement in rotating turbulent Rayleigh-Bénard convection.

PubMed

Weiss, Stephan; Wei, Ping; Ahlers, Guenter

2016-04-01

We present new Nusselt-number (Nu) measurements for slowly rotating turbulent thermal convection in cylindrical samples with aspect ratio Γ=1.00 and provide a comprehensive correlation of all available data for that Γ. In the experiment compressed gasses (nitrogen and sulfur hexafluride) as well as the fluorocarbon C_{6}F_{14} (3M Fluorinert FC72) and isopropanol were used as the convecting fluids. The data span the Prandtl-number (Pr) range 0.74

Extending the Compositional Range of Nanocasting in the Oxozirconium Cluster-Based Metal–Organic Framework NU-1000—A Comparative Structural Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Wenyang; Wang, Zhao; Malonzo, Camille D.

The process of nanocasting in metal-organic frameworks (MOFs) is a versatile approach to modify these porous materials by introducing supporting scaffolds. The nanocast scaffolds can stabilize metal-oxo clusters in MOFs at high temperatures and modulate their chemical environments. Here we demonstrate a range of nanocasting approaches in the MOF NU-1000, which contains hexanuclear oxozirconium clusters (denoted as Zr6 clusters) that are suitable for modification with other metals. We developed methods for introducing SiO2, TiO2, polymeric, and carbon scaffolds into the NU-1000 structure. The responses of NU-1000 towards different scaffold precursors were studied, including the effects on morphology, precursor distribution, andmore » porosity after nanocasting. Upon removal of organic linkers in the MOF by calcination/pyrolysis at 500 °C or above, the Zr6 clusters remained accessible and maintained their Lewis acidity in SiO2 nanocast samples, whereas additional treatment was necessary for Zr6 clusters to become accessible in carbon nanocast samples. Aggregation of Zr6 clusters was largely prevented with SiO2 or carbon scaffolds even after thermal treatment at 500 °C or above. In the case of titania nanocasting, NU- 1000 crystals underwent a pseudomorphic transformation, in which Zr6 clusters reacted with titania to form small oxaggregates of a Zr/Ti mixed oxide with a local structure resembling that of ZrTi2O6. The ability to maintain high densities of discrete Lewis acidic Zr6 clusters on SiO2 or carbon supports at high temperatures provides a starting point for designing new thermally stable catalysts.« less

A randomized controlled trial of skin care protocols for facial resurfacing: lessons learned from the Plastic Surgery Educational Foundation's Skin Products Assessment Research study.

PubMed

Pannucci, Christopher J; Reavey, Patrick L; Kaweski, Susan; Hamill, Jennifer B; Hume, Keith M; Wilkins, Edwin G; Pusic, Andrea L

2011-03-01

The Skin Products Assessment Research Committee was created by the Plastic Surgery Educational Foundation in 2006. The Skin Products Assessment Research study aims were to (1) develop an infrastructure for Plastic Surgery Educational Foundation-conducted, industry-sponsored research in facial aesthetic surgery and (2) test the research process by comparing outcomes of the Obagi Nu-Derm System versus conventional therapy as treatment adjuncts for facial resurfacing procedures. The Skin Products Assessment Research study was designed as a multicenter, double-blind, randomized, controlled trial. The study was conducted in women with Fitzpatrick type I to IV skin, moderate to severe facial photodamage, and periocular and/or perioral fine wrinkles. Patients underwent chemical peel or laser facial resurfacing and were randomized to the Obagi Nu-Derm System or a standard care regimen. The study endpoints were time to reepithelialization, erythema, and pigmentation changes. Fifty-six women were enrolled and 82 percent were followed beyond reepithelialization. There were no significant differences in mean time to reepithelialization between Obagi Nu-Derm System and control groups. The Obagi Nu-Derm System group had a significantly higher median erythema score on the day of surgery (after 4 weeks of product use) that did not persist after surgery. Test-retest photographic evaluations demonstrated that both interrater and intrarater reliability were adequate for primary study outcomes. The authors demonstrated no significant difference in time to reepithelialization between patients who used the Obagi Nu-Derm System or a standard care regimen as an adjunct to facial resurfacing procedures. The Skin Products Assessment Research team has also provided a discussion of future challenges for Plastic Surgery Educational Foundation-sponsored clinical research for readers of this article.

75 FR 37479 - In the Matter of NuScale Power, Inc. and All Other Persons; Who Seek or Obtain Access to...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-29

... date of this Order, submit the fingerprints of one individual whom (a) NuScale nominates as the....\\2\\ NuScale may, at the same time or later, submit the fingerprints of other individuals to whom NuScale seeks to grant access to SGI. Fingerprints shall be submitted and reviewed in accordance with the...

Boundary-value problems in ODE

NASA Astrophysics Data System (ADS)

Tanriverdi, Tanfer

In this thesis we discuss two problems. The first problem is that of Fanno flow in a tube. In [10] the authors have discussed the mathematics of the Fanno model in much more detail than had been previously been done. The analysis in [10] indicates that the Fanno model becomes relevant, if t indicates the unscaled time and t=et , only when t is at least of order O(e- 1) . Indeed, two most important time scales are when t=O(e-1) and t=O(e- 2) . The authors, in the former case, set t=e- 1t1 (t1=t),x=e -11, and obtain the equation 62u6t 21- 62u 6x21=- 2u6 2u6t21 , ( 0.0.1) where u is the velocity of the gas, with p=1,6x1=0 (x1=0). One can follow the solution along the characteristic x1=t1 , and to match with the inviscid behaviour when t1-->0 , u=2+t1 (x1=t1). (0.0.2) In the region t=O(e2) , the authors set t=e2t2, x=e2x2,h= x2t2. For small e , the BC (0.0.02) now becomes u=t2 (x2=t 2), (0.0.3) so that (0.0.1) now has a similarity solution of the form u=t2g( h), u2=e- 1u, and (h2- 1)g'' +4hg'+2g=2g(g+hg' ),' =/ (0.0.4) with g(h)-->2 ash-->1- ,from(0.0.3) (0.0.5) g(h)-->∞ ash-->0- ,(fromthe pressure). ( 0.0.6) In a recent paper [11] the authors discuss the existence of a solution of (0.0.4)-(0.0.6) by using a two dimensional topological shooting method. We also discuss the existence of a solution of (0.0.4)-(0.0.6) by using a shooting method. We first turn the nonlinear ode (0.0.4) into an integral equation and then shoot from the singularity at ∞. The second problem arises when one considers eigenfunction expansions associated with second order ordinary differential equations, as Titchmarsh does in his book. One is concerned with the solutions of the equation - d2ydx2+ q(x)y=ly, (0.0.7) along with certain boundary conditions, where q(x)=-( n2- /)sech 2(x), n=n+/. The problem (0.0.7) has an application in the study of discrete reaction-diffusion equations. Our purpose in this problem is to look in some detail at the equation (0.0.7). We first use contour integrations to give an explicit solution. Secondly, we explore the eigenvalues and the eigenfunctions with the certain boundary conditions. We not only find the spectrum for n = 1, 2, 3, 4 but also explore the eigenvalues for general n where a=0,a=/ and BC is y(x)cosa +y'(x)sin a=0.

Determination of the Flow Field in the Propellant Tank of a Rocket Engine on Completion of the Mission

NASA Astrophysics Data System (ADS)

Fedorov, A. V.; Bedarev, I. A.; Lavruk, S. A.; Trushlyakov, V. I.; Kudentsov, V. Yu.

2018-03-01

In the present work, a method of mathematical simulation is employed to describe processes occurring in the specimens of new equipment and using the remaining propellant in rocket-engine tanks. Within the framework of certain turbulence models, the authors perform a calculation of the flow field in the volume of the tank of the launch-vehicle stage when a hot gas jet is injected into it. A vortex flow structure is revealed; the characteristics of heat transfer for different angles of injection of the jet are determined. The obtained correlation Nu = Nu(Re) satisfactorily describes experimental data.

Determination of the Flow Field in the Propellant Tank of a Rocket Engine on Completion of the Mission

NASA Astrophysics Data System (ADS)

Fedorov, A. V.; Bedarev, I. A.; Lavruk, S. A.; Trushlyakov, V. I.; Kudentsov, V. Yu.

2018-05-01

In the present work, a method of mathematical simulation is employed to describe processes occurring in the specimens of new equipment and using the remaining propellant in rocket-engine tanks. Within the framework of certain turbulence models, the authors perform a calculation of the flow field in the volume of the tank of the launch-vehicle stage when a hot gas jet is injected into it. A vortex flow structure is revealed; the characteristics of heat transfer for different angles of injection of the jet are determined. The obtained correlation Nu = Nu(Re) satisfactorily describes experimental data.

A Universal Shape of Empirical Mass Formula for all Leptons and Quarks

NASA Astrophysics Data System (ADS)

Królikowski, W.

2006-09-01

A specific {ITALIC universal} shape of empirical mass formula is proposed for all leptons nu 1, nu 2 , nu 3 and e-, mu -, tau - as well as all quarks u, c, t and d, s, b of three generations, parametrized by three free constants mu , \\varepsilon , xi assuming four different triplets of values. Four such triplets of parameter values are determined or estimated from the present data. Mass spectra in the four cases are related to each other by {ITALIC shifting} the triplet of parameters mu , \\varepsilon , xi . For charged leptons xi simeq 0 (but probably xi not =0). If for them xi is put to be exactly 0, then mtau = 1776.80 MeV is {ITALIC predicted} after the input of experimental me and mmu (the central value of experimental mtau = 1776.99+ 0.29-0.26 MeV corresponds to xi =1.8times 10-3not =0). For neutrinos 1/xi simeq 0 (but 1/xi not =0 in the case of normal hierarchy m2nu 1 ll m2nu 2 ll m2nu 3). If for neutrinos 1/xi is conjectured to be exactly 0, then (mnu 1, mnu 2, mnu 3) sim (1.5, 1.2, 5.1)times 10-2 eV are {ITALIC predicted} after the input of experimental estimates |m2nu 2 - m2nu 1| sim 8.0times 10-5mskip thickmuskip {eV}2 and |m2nu 3 - m2nu 2| sim 2.4times 10-3mskip thickmuskip {eV}2. Thus, the mass ordering of neutrino states 1 and 2 is then {ITALIC inverted}, while the position of state 3 is {ITALIC normal}.

KSC-2012-1388

NASA Image and Video Library

2012-02-16

VANDENBERG AIR FORCE BASE, Calif. -- Technicians move the tilt-rotation fixture holding NASA's NuSTAR spacecraft inside Orbital Sciences' processing facility at Vandenberg Air Force Base, Calif. The spacecraft will be rotated to horizontal for joining with the Pegasus XL rocket. The Orbital Sciences Pegasus will launch NASA's Nuclear Spectroscopic Telescope Array NuSTAR into space. After the rocket and spacecraft are processed at Vandenberg, they will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean’s Kwajalein Atoll for launch. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit science.nasa.gov/missions/nustar/. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1367

NASA Image and Video Library

2012-02-16

VANDENBERG AIR FORCE BASE, Calif. -- At Vandenberg Air Force Base's processing facility in California, technicians prepare NASA’s NuSTAR spacecraft to be lifted into a tilt-rotation fixture. The spacecraft will be rotated to horizontal for joining with the Pegasus XL rocket. The Orbital Sciences Pegasus will launch NASA's Nuclear Spectroscopic Telescope Array NuSTAR into space. After the rocket and spacecraft are processed at Vandenberg, they will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean’s Kwajalein Atoll for launch. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit science.nasa.gov/missions/nustar/. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1381

NASA Image and Video Library

2012-02-16

VANDENBERG AIR FORCE BASE, Calif. -- At Vandenberg Air Force Base in California, technicians inside Orbital Sciences' processing facility watch as NASA's NuSTAR spacecraft is lifted by the tilt-rotation fixture. The spacecraft will be rotated to horizontal for joining with the Pegasus XL rocket. The Orbital Sciences Pegasus will launch NASA's Nuclear Spectroscopic Telescope Array NuSTAR into space. After the rocket and spacecraft are processed at Vandenberg, they will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean’s Kwajalein Atoll for launch. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit science.nasa.gov/missions/nustar/. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1371

NASA Image and Video Library

2012-02-16

VANDENBERG AIR FORCE BASE, Calif. -- Inside Orbital Sciences' processing facility at Vandenberg Air Force Base in California, a lifting device is lowered toward NASA's NuSTAR spacecraft. The spacecraft will be rotated to horizontal for joining with the Pegasus XL rocket. The Orbital Sciences Pegasus will launch NASA's Nuclear Spectroscopic Telescope Array NuSTAR into space. After the rocket and spacecraft are processed at Vandenberg, they will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean’s Kwajalein Atoll for launch. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit science.nasa.gov/missions/nustar/. Photo credit: NASA/Randy Beaudoin, VAFB

Turn-Directed α-β Conformational Transition of α-syn12 Peptide at Different pH Revealed by Unbiased Molecular Dynamics Simulations

PubMed Central

Liu, Lei; Cao, Zanxia

2013-01-01

The transition from α-helical to β-hairpin conformations of α-syn12 peptide is characterized here using long timescale, unbiased molecular dynamics (MD) simulations in explicit solvent models at physiological and acidic pH values. Four independent normal MD trajectories, each 2500 ns, are performed at 300 K using the GROMOS 43A1 force field and SPC water model. The most clustered structures at both pH values are β-hairpin but with different turns and hydrogen bonds. Turn9-6 and four hydrogen bonds (HB9-6, HB6-9, HB11-4 and HB4-11) are formed at physiological pH; turn8-5 and five hydrogen bonds (HB8-5, HB5-8, HB10-3, HB3-10 and HB12-1) are formed at acidic pH. A common folding mechanism is observed: the formation of the turn is always before the formation of the hydrogen bonds, which means the turn is always found to be the major determinant in initiating the transition process. Furthermore, two transition paths are observed at physiological pH. One of the transition paths tends to form the most-clustered turn and improper hydrogen bonds at the beginning, and then form the most-clustered hydrogen bonds. Another transition path tends to form the most-clustered turn, and turn5-2 firstly, followed by the formation of part hydrogen bonds, then turn5-2 is extended and more hydrogen bonds are formed. The transition path at acidic pH is as the same as the first path described at physiological pH. PMID:23708094

The Supercritical Pile Model for GRBs

NASA Technical Reports Server (NTRS)

Kazanas, D.

2005-01-01

We present the spectral and temporal radiative signatures expected within the "Supercritical Pile" model of Gamma Ray Bursts (GRB). This model is motivated by the need for a process that provides the dissipation necessary in GRB and presents a well defined scheme for converting the energy stored in the relativistic protons of the Relativistic Blast Waves (RBW) associated with GRB into radiation; at the same time it leads to spectra which exhibit a peak in the burst nuF(sub nu) distribution at an energy E(sub p) approx. equal to 1 MeV in the observer s frame, in agreement with observation and largely independent of the Lorentz factor r of the associated relativistic outflow. Futhermore, this scheme does not require (but does not preclude) acceleration of particles at the shock other than that provided by the isotropization of the flow bulk kinetic energy on the RBW frame. In the present paper we model in detail the evolution of protons, electrons and photons from a RBW to produce detailed spectra of the prompt GRB phase as a function of time from across a very broad range spanning roughly 4 log10Gamma decades in frequency. The model spectra are in general agreement with observations and provide a means for the delineating of the model parameters through direct comparison with trends observed in GRB properties.

The Supercritical Pile Model for GRBs

NASA Technical Reports Server (NTRS)

Kazanas, Demos

2006-01-01

We present the spectral and temporal radiative signatures expected within the Supercritical Pile model of Gamma Ray Bursts (GRB). This model is motivated by the need for a process that provides the dissipation necessary in GRB and presents a well defined scheme for converting the energy stored in the relativistic protons of the Relativistic Blast Waves (RBW) associated with GRB into radiation; at the same time it leads to spectra which exhibit a peak in the burst nuF(sub nu) distribution at an energy E(sub p) approximately equal to 1 MeV in the observer s frame, in agreement with observation and largely independent of the Lorentz factor GAMMA of the associated relativistic outflow. Furthermore, this scheme does not require (but does not preclude) acceleration of particles at the shock other than that provided by the isotropization of the flow bulk kinetic energy on the RBW frame. In the present paper we model in detail the evolution of protons, electrons and photons from a RBW to produce detailed spectra of the prompt GRB phase as a function of time from across a very broad range spanning roughly 4 log10 GAMMA decades in frequency. The model spectra are in general agreement with observations and provide a means for the delineating of the model parameters through direct comparison with trends observed in GRB properties.

Enhanced gastric cancer growth potential of mesenchymal stem cells derived from gastric cancer tissues educated by CD4+ T cells.

PubMed

Xu, Rongman; Zhao, Xiangdong; Zhao, Yuanyuan; Chen, Bin; Sun, Li; Xu, Changgen; Shen, Bo; Wang, Mei; Xu, Wenrong; Zhu, Wei

2018-04-01

Gastric cancer mesenchymal stem cells (GC-MSCs) can promote the development of tumour growth. The tumour-promoting role of tumour-associated MSCs and T cells has been demonstrated. T cells as the major immune cells may influence and induce a pro-tumour phenotype in MSCs. This study focused on whether CD4 + T cells can affect GC-MSCs to promote gastric cancer growth. CD4 + T cells upregulation of programmed death ligand 1 (PD-L1) expression in GC-MSCs through the phosphorylated signal transducer and activator of transcription (p-STAT3) signalling pathway was confirmed by immunofluorescence, western blotting and RT-PCR. Migration of GC cells was detected by Transwell migration assay, and apoptosis of GC cells was measured by flow cytometry using annexin V/propidium iodide double staining. CD4 + T cell-primed GC-MSCs promoted GC growth in a subcutaneously transplanted tumour model in BALB/c nu/nu mice. Gastric cancer mesenchymal stem cells stimulated by activated CD4 + T cells promoted migration of GC cells and enhanced GC growth potential in BALB/c nu/nu xenografts. PD-L1 upregulation of GC-MSCs stimulated by CD4 + T cells was mediated through the p-STAT3 signalling pathway. CD4 + T cells-primed GC-MSCs have greater GC volume and growth rate-promoting role than GC-MSCs, with cancer cell-intrinsic PD-1/mammalian target of rapamycin (mTOR) signalling activation. This study showed that GC-MSCs are plastic. The immunophenotype of GC-MSCs stimulated by CD4 + T cells has major changes that may influence tumour cell growth. This research was based on the interaction between tumour cells, MSCs and immune cells, providing a new understanding of the development and immunotherapy of GC. © 2017 John Wiley & Sons Ltd.

In Vivo Consumption of Cranberry Exerts ex Vivo Antiadhesive Activity against FimH-Dominated Uropathogenic Escherichia coli: A Combined in Vivo, ex Vivo, and in Vitro Study of an Extract from Vaccinium macrocarpon.

PubMed

Rafsanjany, Nasli; Senker, Jandirk; Brandt, Simone; Dobrindt, Ulrich; Hensel, Andreas

2015-10-14

For investigation of the molecular interaction of cranberry extract with adhesins of uropathogenic Escherichia coli (UPEC), urine from four volunteers consuming standardized cranberry extract (proanthocyanidin content = 1.24%) was analyzed within ex vivo experiments, indicating time-dependent significant inhibition of 40-50% of bacterial adhesion of UPEC strain NU14 to human T24 bladder cells. Under in vitro conditions a dose-dependent increase in bacterial adhesion was observed with proanthocyanidin-enriched cranberry Vaccinium macrocarpon extract (proanthocyanidin content = 21%). Confocal laser scanning microscopy and scanning electron microscopy proved that V.m. extract led to the formation of bacterial clusters on the outer plasma membrane of the host cells without subsequent internalization. This agglomerating activity was not observed when a PAC-depleted extract (V.m. extract(≠PAC)) was used, which showed significant inhibition of bacterial adhesion in cases where type 1 fimbriae dominated and mannose-sensitive UPEC strain NU14 was used. V.m. extract(≠PAC) had no inhibitory activity against P- and F1C-fimbriae dominated strain 2980. Quantitative gene expression analysis indicated that PAC-containing as well as PAC-depleted cranberry extracts increased the fimH expression in NU14 as part of a feedback mechanism after blocking FimH. For strain 2980 the PAC-containing extract led to up-regulation of P- and F1C-fimbriae, whereas the PAC-depleted extract had no influence on gene expression. V.m. and V.m. extract(≠PAC) did not influence biofilm and curli formation in UPEC strains NU14 and 2980. These data lead to the conclusion that also proanthocyanidin-free cranberry extracts exert antiadhesive activity by interaction with mannose-sensitive type 1 fimbriae of UPEC.

High efficiency environmental sampling with UV-cured peelable coatings (aka NuGoo project)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Henzl, Vladimir; Junghans, Sylvia Ann; Lakis, Rollin Evan

This report presents slides on CA Related Project (FY13-17); Environmental sampling by IAEA (not only) during CA; Decontamination gels; Cotton swipes vs. decon gel (FY15); Contamination removal study; The origins of the NuGoo; NuGoo – proof of concept; NuGoo – FY17 project ($250K); LED lamp – which one works and why; Selecting photoinitiator; Monomers and oligomers; Results.

Modeling and Compensating Temperature-Dependent Non-Uniformity Noise in IR Microbolometer Cameras

PubMed Central

Wolf, Alejandro; Pezoa, Jorge E.; Figueroa, Miguel

2016-01-01

Images rendered by uncooled microbolometer-based infrared (IR) cameras are severely degraded by the spatial non-uniformity (NU) noise. The NU noise imposes a fixed-pattern over the true images, and the intensity of the pattern changes with time due to the temperature instability of such cameras. In this paper, we present a novel model and a compensation algorithm for the spatial NU noise and its temperature-dependent variations. The model separates the NU noise into two components: a constant term, which corresponds to a set of NU parameters determining the spatial structure of the noise, and a dynamic term, which scales linearly with the fluctuations of the temperature surrounding the array of microbolometers. We use a black-body radiator and samples of the temperature surrounding the IR array to offline characterize both the constant and the temperature-dependent NU noise parameters. Next, the temperature-dependent variations are estimated online using both a spatially uniform Hammerstein-Wiener estimator and a pixelwise least mean squares (LMS) estimator. We compensate for the NU noise in IR images from two long-wave IR cameras. Results show an excellent NU correction performance and a root mean square error of less than 0.25 ∘C, when the array’s temperature varies by approximately 15 ∘C. PMID:27447637

First results from KamLAND: evidence for reactor antineutrino disappearance.

PubMed

Eguchi, K; Enomoto, S; Furuno, K; Goldman, J; Hanada, H; Ikeda, H; Ikeda, K; Inoue, K; Ishihara, K; Itoh, W; Iwamoto, T; Kawaguchi, T; Kawashima, T; Kinoshita, H; Kishimoto, Y; Koga, M; Koseki, Y; Maeda, T; Mitsui, T; Motoki, M; Nakajima, K; Nakajima, M; Nakajima, T; Ogawa, H; Owada, K; Sakabe, T; Shimizu, I; Shirai, J; Suekane, F; Suzuki, A; Tada, K; Tajima, O; Takayama, T; Tamae, K; Watanabe, H; Busenitz, J; Djurcic, Z; McKinny, K; Mei, D-M; Piepke, A; Yakushev, E; Berger, B E; Chan, Y D; Decowski, M P; Dwyer, D A; Freedman, S J; Fu, Y; Fujikawa, B K; Heeger, K M; Lesko, K T; Luk, K-B; Murayama, H; Nygren, D R; Okada, C E; Poon, A W P; Steiner, H M; Winslow, L A; Horton-Smith, G A; McKeown, R D; Ritter, J; Tipton, B; Vogel, P; Lane, C E; Miletic, T; Gorham, P W; Guillian, G; Learned, J G; Maricic, J; Matsuno, S; Pakvasa, S; Dazeley, S; Hatakeyama, S; Murakami, M; Svoboda, R C; Dieterle, B D; DiMauro, M; Detwiler, J; Gratta, G; Ishii, K; Tolich, N; Uchida, Y; Batygov, M; Bugg, W; Cohn, H; Efremenko, Y; Kamyshkov, Y; Kozlov, A; Nakamura, Y; De Braeckeleer, L; Gould, C R; Karwowski, H J; Markoff, D M; Messimore, J A; Nakamura, K; Rohm, R M; Tornow, W; Young, A R; Wang, Y-F

2003-01-17

KamLAND has measured the flux of nu;(e)'s from distant nuclear reactors. We find fewer nu;(e) events than expected from standard assumptions about nu;(e) propagation at the 99.95% C.L. In a 162 ton.yr exposure the ratio of the observed inverse beta-decay events to the expected number without nu;(e) disappearance is 0.611+/-0.085(stat)+/-0.041(syst) for nu;(e) energies >3.4 MeV. In the context of two-flavor neutrino oscillations with CPT invariance, all solutions to the solar neutrino problem except for the "large mixing angle" region are excluded.

Evaluation of NU-WRF Rainfall Forecasts for IFloodS

NASA Technical Reports Server (NTRS)

Wu, Di; Peters-Lidard, Christa; Tao, Wei-Kuo; Petersen, Walter

2016-01-01

The Iowa Flood Studies (IFloodS) campaign was conducted in eastern Iowa as a pre- GPM-launch campaign from 1 May to 15 June 2013. During the campaign period, real time forecasts are conducted utilizing NASA-Unified Weather Research and Forecasting (NU-WRF) model to support the everyday weather briefing. In this study, two sets of the NU-WRF rainfall forecasts are evaluated with Stage IV and Multi-Radar Multi-Sensor (MRMS) Quantitative Precipitation Estimation (QPE), with the objective to understand the impact of Land Surface initialization on the predicted precipitation. NU-WRF is also compared with North American Mesoscale Forecast System (NAM) 12 kilometer forecast. In general, NU-WRF did a good job at capturing individual precipitation events. NU-WRF is also able to replicate a better rainfall spatial distribution compare with NAM. Further sensitivity tests show that the high-resolution makes a positive impact on rainfall forecast. The two sets of NU-WRF simulations produce very close rainfall characteristics. The Land surface initialization do not show significant impact on short term rainfall forecast, and it is largely due to the soil conditions during the field campaign period.

A high sensitivity search for electron anti-neutrinos from the sun and other sources at Kamland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eguchi, K.; Enomoto, S.; Furuno, K.

2003-10-21

Data corresponding to a KamLAND detector exposure of 0.28 kton-year has been used to search for {bar {nu}}{sub e}'s in the energy range 8.3 MeV < E{sup {bar {nu}}{sub e}} < 14.8 MeV. No candidates were found for an expected background of 1.1 {+-} 0.4 events. This result can be used to obtain a limit on {bar {nu}}{sub e} fluxes of any origin. Assuming that all {bar {nu}}{sub e} flux has its origin in the Sun and has the characteristic {sup 8}B solar {nu}{sub e} energy spectrum, we obtain an upper limit of 3.7 x 10{sup 2} cm{sup -2} s{supmore » -1} (90 percent C.L.) on the {bar {nu}}{sub e} flux. We interpret this limit, corresponding to 2.8 x 10{sup -4} of the Standard Solar Model {sup 8}B {nu}{sub e} flux, in the framework of spin-flavor precession and neutrino decay models.« less

Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex.

PubMed

Alqarni, Saad S M; Murthy, Andal; Zhang, Wei; Przewloka, Marcin R; Silva, Ana P G; Watson, Aleksandra A; Lejon, Sara; Pei, Xue Y; Smits, Arne H; Kloet, Susan L; Wang, Hongxin; Shepherd, Nicholas E; Stokes, Philippa H; Blobel, Gerd A; Vermeulen, Michiel; Glover, David M; Mackay, Joel P; Laue, Ernest D

2014-08-08

The nucleosome remodeling and deacetylase (NuRD) complex is a widely conserved transcriptional co-regulator that harbors both nucleosome remodeling and histone deacetylase activities. It plays a critical role in the early stages of ES cell differentiation and the reprogramming of somatic to induced pluripotent stem cells. Abnormalities in several NuRD proteins are associated with cancer and aging. We have investigated the architecture of NuRD by determining the structure of a subcomplex comprising RbAp48 and MTA1. Surprisingly, RbAp48 recognizes MTA1 using the same site that it uses to bind histone H4, showing that assembly into NuRD modulates RbAp46/48 interactions with histones. Taken together with other results, our data show that the MTA proteins act as scaffolds for NuRD complex assembly. We further show that the RbAp48-MTA1 interaction is essential for the in vivo integration of RbAp46/48 into the NuRD complex. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae

PubMed Central

Huard, Sylvain; Morettin, Alan; Fullerton, Morgan D.; Côté, Jocelyn

2017-01-01

Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is required for stress granule formation upon glucose deprivation but not heat stress. Further, the Tip60 complex, the human homolog of the NuA4 complex, is required for stress granule formation in cancer cell lines. Surprisingly, the impact of NuA4 on glucose-deprived stress granule formation is partially mediated through regulation of acetyl-CoA levels, which are elevated in NuA4 mutants. While elevated acetyl-CoA levels suppress the formation of glucose-deprived stress granules, decreased acetyl-CoA levels enhance stress granule formation upon glucose deprivation. Further our work suggests that NuA4 regulates acetyl-CoA levels through the Acetyl-CoA carboxylase Acc1. Altogether this work establishes both NuA4 and the metabolite acetyl-CoA as critical signaling pathways regulating the formation of glucose-deprived stress granules. PMID:28231279

SEARCH FOR EXTRATERRESTRIAL ANTINEUTRINO SOURCES WITH THE KamLAND DETECTOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gando, A.; Gando, Y.; Ichimura, K.

2012-02-01

We present the results of a search for extraterrestrial electron antineutrinos ({nu}-bar{sub e}'s) in the energy range 8.3 MeV < E{sub {nu}}-bar{sub e} < 31.8 MeV using the KamLAND detector. In an exposure of 4.53 kton-year, we identify 25 candidate events. All of the candidate events can be attributed to background, most importantly neutral current atmospheric neutrino interactions, setting an upper limit on the probability of {sup 8}B solar {nu}{sub e}'s converting into {nu}-bar{sub e}'s at 5.3 Multiplication-Sign 10{sup -5} (90% CL), if we assume an undistorted {nu}-bar{sub e} shape. This limit corresponds to a solar {nu}-bar{sub e} flux ofmore » 93 cm{sup -2} s{sup -1} or an event rate of 1.6 events (kton - year){sup -1} above the energy threshold (E{sub {nu}}-bar{sub e}>=8.3 MeV). The present data also allows us to set more stringent limits on the diffuse supernova neutrino flux and on the annihilation rates for light dark matter particles.« less

Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report October 2014

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ogden, Dan

Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report October 2014 Highlights • Rory Kennedy, Dan Ogden and Brenden Heidrich traveled to Germantown October 6-7, for a review of the Infrastructure Management mission with Shane Johnson, Mike Worley, Bradley Williams and Alison Hahn from NE-4 and Mary McCune from NE-3. Heidrich briefed the group on the project progress from July to October 2014 as well as the planned path forward for FY15. • Jim Cole gave two invited university seminars at Ohio State University and University of Florida, providing an overview of NSUF including available capabilities and themore » process for accessing facilities through the peer reviewed proposal process. • Jim Cole and Rory Kennedy co-chaired the NuMat meeting with Todd Allen. The meeting, sponsored by Elsevier publishing, was held in Clearwater, Florida, and is considered one of the premier nuclear fuels and materials conferences. Over 340 delegates attended with 160 oral and over 200 posters presented over 4 days. • Thirty-one pre-applications were submitted for NSUF access through the NE-4 Combined Innovative Nuclear Research Funding Opportunity Announcement. • Fourteen proposals were received for the NSUF Rapid Turnaround Experiment Summer 2014 call. Proposal evaluations are underway. • John Jackson and Rory Kennedy attended the Nuclear Fuels Industry Research meeting. Jackson presented an overview of ongoing NSUF industry research.« less

On the Link Between Emotionally Driven Impulsivity and Aggression: Evidence From a Validation Study on the Dutch UPPS-P.

PubMed

Bousardt, A M C; Noorthoorn, E O; Hoogendoorn, A W; Nijman, H L I; Hummelen, J W

2018-06-01

The UPPS-P seems to be a promising instrument for measuring different domains of impulsivity in forensic psychiatric patients. Validation studies of the instrument however, have been conducted only in student groups. In this validation study, three groups completed the Dutch UPPS-P: healthy student ( N = 94) and community ( N = 134) samples and a forensic psychiatric sample ( N = 73). The five-factor structure reported previously could only be substantiated in a confirmatory factor analysis over the combined groups but not in the subsamples. Subgroup sample sizes might be too small to allow such complex analyses. Internal consistency, as assessed by Cronbach's alpha, was high on most subscale and sample combinations. In explaining aggression, especially the initial subscale negative urgency (NU) was related to elevated scores on self-reported aggression in the healthy samples (student and community). The current study is the second study that found a relationship between self-reported NU and aggression highlighting the importance of addressing this behavioural domain in aggression management therapy.

Development of Implicit Compact Methods for Chemically Reacting Flows

DTIC Science & Technology

2009-02-28

NSP_P), DKt (NSP_P), & ! stoichiometric coeffs (# mols produced/destroyed) & NUK(NSP_P), & ! mass coeffs: NUK(k)*WK(k) & NUKWK(NSP_P), & & WK... DKt UC UCr wc WCz NUK NUKWK ! (nu_0 sstoich Yfuel Yox Yfuel_F Yox_A Z PHI omega SOURCE q HEAT = SpecificHeat(T) = 0 .do...RHO*T) dot_product(DK,YKr) ! correction vel. for mass conservation dot_product(DK,YKrr)+dot_product(( DKt *Tr),YKr) dot_product(DK,YKz) ! correction

Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Timothy C.; Vermeulen, Nicolaas A.; Kim, In Soo

The synthesis of NU-1000, a mesoporous metal-organic framework (MOF), can be conducted efficiently on a multigram scale from inexpensive starting materials. NU-1000 has been reported as an excellent candidate for gas separation and catalysis. In particular, it is ideal for the catalytic deactivation of nerve agents and shows great promise as a new generic platform for a wide range of applications. Multiple post-synthetic modification protocols have been developed using NU-1000 as the parent material, making it a potentially useful scaffold for several catalytic applications. The procedure for the preparation of NU-1000 can be scaled up reliably, and it is suitablemore » for the production of 50 g of the tetracarboxylic acid containing organic linker and 200 mg–2.5 g of NU-1000. Lastly, the entire synthesis is performed without purification by column chromatography and can be completed within 10 d.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

H.E. Mynick; A.H. Boozer

We study the effect on neoclassical transport of applying a fluctuating electrostatic spectrum, such as produced either by plasma turbulence, or imposed externally. For tokamaks, it is usually assumed that the neoclassical and ''anomalous'' contributions to the transport roughly superpose, D = D{sub nc} + D{sub an}, an intuition also used in modeling stellarators. An alternate intuition, however, is one where it is the collisional and anomalous scattering frequencies which superpose, {nu}{sub ef} = {nu} + {nu}{sub an}. For nonaxisymmetric systems, in regimes where {partial_derivative}D/{partial_derivative}{nu} < 0, this ''{nu}{sub ef} picture'' implies that turning on the fluctuations can decrease themore » total radial transport. Using numerical and analytic means, it is found that the total transport has contributions conforming to each of these intuitions, either of which can dominate. In particular, for stellarators, the {nu}{sub ef} picture is often valid, producing transport behavior differing from tokamaks.« less

Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000

DOE PAGES

Wang, Timothy C.; Vermeulen, Nicolaas A.; Kim, In Soo; ...

2015-12-17

The synthesis of NU-1000, a mesoporous metal-organic framework (MOF), can be conducted efficiently on a multigram scale from inexpensive starting materials. NU-1000 has been reported as an excellent candidate for gas separation and catalysis. In particular, it is ideal for the catalytic deactivation of nerve agents and shows great promise as a new generic platform for a wide range of applications. Multiple post-synthetic modification protocols have been developed using NU-1000 as the parent material, making it a potentially useful scaffold for several catalytic applications. The procedure for the preparation of NU-1000 can be scaled up reliably, and it is suitablemore » for the production of 50 g of the tetracarboxylic acid containing organic linker and 200 mg–2.5 g of NU-1000. Lastly, the entire synthesis is performed without purification by column chromatography and can be completed within 10 d.« less

Surface Raman spectroscopy of the interface of tris-(8-hydroxyquinoline) aluminum with Mg.

PubMed

Davis, Robert J; Pemberton, Jeanne E

2009-07-29

Surface Raman spectroscopy in ultrahigh vacuum is used to interrogate interfaces formed between tris-(8-hydroxyquinoline) aluminum (Alq(3)) and vapor-deposited Mg. The Raman spectral results for deposition of Mg mass thicknesses between 5 and 20 A indicate formation of a complex interfacial region composed primarily of Mg-Alq(3) adducts and small-grained amorphous or nanocrystalline graphite, the presence of which may have a significant effect on the electronic properties of this metal-organic interface. The observed shifts in nu(ring), nu(C-N), nu(Al-N), and nu(Al-O) modes along with the appearance of nu(Mg-C) and nu(Mg-O) modes suggest a structure for the Mg-Alq(3) adduct in which Mg is bound to the O and C atoms of Alq(3). In addition, several intense, broad modes are observed that are consistent with partial graphitization of the Alq(3) film.

NuSTAR hard X-ray observations of the Jovian magnetosphere during Juno perijove and apojove intervals

NASA Astrophysics Data System (ADS)

Dunn, W.; Mori, K.; Hailey, C. J.; Branduardi-Raymont, G.; Grefenstette, B.; Jackman, C. M.; Hord, B. J.; Ray, L. C.

2017-12-01

The Nuclear Spectroscopic Telescope Array (NuSTAR) is the first focusing hard X-ray telescope operating in the 3-79 keV band with sub-arcminute angular resolution (18" FWHM). For the first time, NuSTAR provides sufficient sensitivity to detect/resolve hard X-ray emission from Jupiter above 10 keV, since the in-situ Ulysses observation failed to detect X-ray emission in the 27-48 keV band [Hurley et al. 1993]. The initial, exploratory NuSTAR observation of Jupiter was performed in February 2015 with 100 ksec exposure. NuSTAR detected hard X-ray emission (E > 10 keV) from the south polar region at a marginally significance of 3 sigma level [Mori et al. 2016, AAS meeting poster]. This hard X-ray emission is likely an extension of the non-thermal bremsstrahlung component detected up to 7 keV by XMM-Newton [Branduardi-Raymont et al. 2007]. The Ulysses non-detection suggests there should be a spectral cutoff between 7 and 27 keV. Most intriguingly, the NuSTAR detection of hard X-ray emission from the south aurora is in contrast to the 2003 XMM-Newton observations where soft X-ray emission below 8 keV was seen from both the north and south poles [Gladstone et al. 2002]. Given the marginal, but tantalizing, hard X-ray detection of the southern Jovian aurora, a series of NuSTAR observations with total exposure of nearly half a million seconds were approved in the NuSTAR GO and DDT program. These NuSTAR observations coincided with one Juno apojove (in June 2017) and three perijoves (in May, July and September 2017), also joining the multi-wavelength campaigns of observing Jupiter coordinating with Chandra and XMM-Newton X-ray telescope (below 10 keV) and HST. We will present NuSTAR imaging, spectral and timing analysis of Jupiter. NuSTAR imaging analysis will map hard X-ray emission in comparison with soft X-ray and UV images. In addition to investigating any distinctions between the soft and hard X-ray morphology of the Jovian aurorae, we will probe whether hard X-ray emission is spatially associated with the FUV auroral oval. NuSTAR spectral analysis will measure to how high an energy the non-thermal bremsstrahlung component extends, and detect an expected spectral cutoff between 7 and 27 keV. Since NuSTAR operates in the hard X-ray energy band, it probes the maximum energy of accelerating electrons in the Jovian magnetosphere.

Evaluation of the nutrient-upgraded rodent food bar for rodent spaceflight experiments.

PubMed

Sun, Gwo-Shing; Tou, Janet C; Liittschwager, Kurt; Herrera, Anna M; Hill, Esther L; Girten, Beverly; Reiss-Bubenheim, Debra; Vasques, Marilyn

2010-01-01

Selection of an appropriate diet for rodent spaceflight experiments is critical and may have significant effects on mission results. The National Aeronautics and Space Administration (NASA) rodent food bar (RFB) was reformulated and designated as the nutrient-upgraded RFB (NuRFB). The objectives of this study were to determine whether the NuRFB nutrient formulation meets the 1995 National Research Council (NRC) nutrient recommendations and whether the NuRFB can be used for short-term (45-d) and long-term (90-d) spaceflight experiments. Nutrient and moisture analyses of the NuRFB were performed. Young (age 13-14 wk) male Sprague-Dawley rats (n=16/group) were individually caged and fed a diet treatment consisting of 1) NuRFB, 2) RFB, or 3) modified AIN-93G containing 4% instead of the 7% fat for 45- or 90-d. At the end of the study, organs were weighted, and serum clinical chemistry indicators of organ function and hematologic measurements were determined. Chemical analysis of the diet ingredients showed that the NuRFB met the 1995 NRC nutrient recommendations for rats. Subsequent animal feeding studies showed that NuRFB was comparable to RFB and modified AIN-93G for supporting rat growth and body weight maintenance. In addition, the safety of the NuRFB for use as a spaceflight diet was indicated by the absence of changes in organ weight or function. Based on the study results, the NuRFB performed similarly to the RFB and met the criteria necessary for short-term and long-term rodent spaceflight experiments. Published by Elsevier Inc.

First NuSTAR Observations of the BL Lac-type Blazar PKS 2155-304: Constraints on the Jet Content and Distribution of Radiating Particles

NASA Astrophysics Data System (ADS)

Madejski, G. M.; Nalewajko, K.; Madsen, K. K.; Chiang, J.; Baloković, M.; Paneque, D.; Furniss, A. K.; Hayashida, M.; Urry, C. M.; Sikora, M.; Ajello, M.; Blandford, R. D.; Harrison, F. A.; Sanchez, D.; Giebels, B.; Stern, D.; Alexander, D. M.; Barret, D.; Boggs, S. E.; Christensen, F. E.; Craig, W. W.; Forster, K.; Giommi, P.; Grefenstette, B.; Hailey, C.; Hornstrup, A.; Kitaguchi, T.; Koglin, J. E.; Mao, P. H.; Miyasaka, H.; Mori, K.; Perri, M.; Pivovaroff, M. J.; Puccetti, S.; Rana, V.; Westergaard, N. J.; Zhang, W. W.; Zoglauer, A.

2016-11-01

We report the first hard X-ray observations with NuSTAR of the BL Lac-type blazar PKS 2155-304, augmented with soft X-ray data from XMM-Newton and γ-ray data from the Fermi Large Area Telescope, obtained in 2013 April when the source was in a very low flux state. A joint NuSTAR and XMM spectrum, covering the energy range 0.5-60 keV, is best described by a model consisting of a log-parabola component with curvature β ={0.3}-0.1+0.2 and a (local) photon index 3.04 ± 0.15 at photon energy of 2 keV, and a hard power-law tail with photon index 2.2 ± 0.4. The hard X-ray tail can be smoothly joined to the quasi-simultaneous γ-ray spectrum by a synchrotron self-Compton component produced by an electron distribution with index p = 2.2. Assuming that the power-law electron distribution extends down to γ min = 1 and that there is one proton per electron, an unrealistically high total jet power of L p ˜ 1047 erg s-1 is inferred. This can be reduced by two orders of magnitude either by considering a significant presence of electron-positron pairs with lepton-to-proton ratio {n}{{e}+{{e}}-}/{n}{{p}}˜ 30, or by introducing an additional, low-energy break in the electron energy distribution at the electron Lorentz factor γ br1 ˜ 100. In either case, the jet composition is expected to be strongly matter-dominated.

Carbon and nutrients recycling when leaves falling off: mycorrhizal association matters

NASA Astrophysics Data System (ADS)

Zhang, H., II; Lü, X. T.; Hartmann, H.; Han, X.; Trumbore, S.

2016-12-01

Root-associated mycorrhizal fungi is being increasingly recognized for their roles in influencing soil carbon (C) storage, plant growth and nutrient cycling, whereas mycorrhizae-mediated C dynamics and nutrient acquisition strategy strongly different. Because of a reinforcing feedback from belowground, how different mycorrhizal plants differ in aboveground nutrient status and recycle from senesced to green leaves remains unknown. Based on a global database of C and nutrients concentrations in plant green and senesced leaves, we further identified plant mycorrhizal types (here focus on arbuscular mycorrhizal (AM) and ectomycorrhizal (ECM) plants) for woody species and tested whether mycorrhizal types showing consistent effects in plant nutrient status and recycle. Generally, nutrient resorptions from senesced to green leaves for ECM plants are more conservative, balanced and sensitive to climate compare to AM plants. Specifically, we first found lower nutrients concentrations in green and senesced leaves whereas greater nutrient resorption efficiency (NuR) for ECM vs. AM plants. However, C concentration in green and senesced leaves were significant greater while NuR was lower for ECM plants. Second, compare to that for AM plants, we found a general balanced N:P resorption ratio ( 1) for ECM plants, indicating ECM plants had greater ability to balance their N and P resorption simultaneously. Third, we found NuR in N, P and K (potassium) for ECM plants were sensitive to the variation of MAT and MAP while these for AM plants showed no clear trend. Our results suggested that accounting for the influence of mycorrhizae on C and nutrient dynamics in vegetation models will be critical for predicting ecosystem responses and feedbacks to climate change.

Improving Heart rate variability in sleep apnea patients: differences in treatment with auto-titrating positive airway pressure (APAP) versus conventional CPAP.

PubMed

Karasulu, Levent; Epöztürk, Pinar Ozkan; Sökücü, Sinem Nedime; Dalar, Levent; Altin, Sedat

2010-08-01

The effect of positive airway pressure treatments in different modalities on the cardiovascular consequences of the disease in sleep apnea patients is still unclear. We aimed to compare auto-titrating positive airway pressure (APAP) and conventional continuous positive airway pressure (CPAP) in terms of improving heart rate variability (HRV) in obstructive sleep apnea patients. This was a prospective study done in a tertiary research hospital. All patients underwent a manual CPAP titration procedure to determine the optimal pressure that abolishes abnormal respiratory events. Then patients underwent two treatment nights, one under APAP mode and one under conventional CPAP mode with a 1-week interval. Forty newly diagnosed obstructive sleep apnea patients were enrolled in the study. We compared heart rate variability analysis parameters between the APAP night and the CPAP night. This final analysis included the data of 28 patients (M/F: 22/6; mean age = 46 +/- 10 years). Sleep characteristics were comparable between the two treatment nights, whereas all-night time domains of HRV analysis such as HF, nuLF, and LF/HF were different between APAP and CPAP nights (2.93 +/- 0.31 vs. 3.01 +/- 0.31; P = 0.041; 0.75 +/- 0.13 vs. 0.71 +/- 0.14; P = 0.027; and 4.37 +/- 3.24 vs. 3.56 +/- 2.07; P = 0.023, respectively). HRV analysis for individual sleep stages showed that Stage 2 LF, nuLF, nuHF, LF/HF parameters entirely improved under CPAP treatment whereas APAP treatment resulted in nonsignificant changes. These results suggest that despite comparable improvement in abnormal respiratory events with APAP or CPAP treatments, CPAP may be superior to APAP in terms of correcting cardiovascular alterations in sleep apnea patients.

A Meta-Analysis of Motivational Interviewing Process: Technical, Relational, and Conditional Process Models of Change

PubMed Central

Magill, Molly; Apodaca, Timothy R.; Borsari, Brian; Gaume, Jacques; Hoadley, Ariel; Gordon, Rebecca E.F.; Tonigan, J. Scott; Moyers, Theresa

2018-01-01

Objective In the present meta-analysis, we test the technical and relational hypotheses of Motivational Interviewing (MI) efficacy. We also propose an a priori conditional process model where heterogeneity of technical path effect sizes should be explained by interpersonal/relational (i.e., empathy, MI Spirit) and intrapersonal (i.e., client treatment seeking status) moderators. Method A systematic review identified k = 58 reports, describing 36 primary studies and 40 effect sizes (N = 3025 participants). Statistical methods calculated the inverse variance-weighted pooled correlation coefficient for the therapist to client and the client to outcome paths across multiple target behaviors (i.e., alcohol use, other drug use, other behavior change). Results Therapist MI-consistent skills were correlated with more client change talk (r = .55, p < .001) as well as more sustain talk (r = .40, p < .001). MI-inconsistent skills were correlated with more sustain talk (r = .16, p < .001), but not change talk. When these indicators were combined into proportions, as recommended in the Motivational Interviewing Skill Code, the overall technical hypothesis was supported. Specifically, proportion MI consistency was related to higher proportion change talk (r = .11, p = .004) and higher proportion change talk was related to reductions in risk behavior at follow up (r = −.16, p < .001). When tested as two independent effects, client change talk was not significant, but sustain talk was positively associated with worse outcome (r = .19, p < .001). Finally, the relational hypothesis was not supported, but heterogeneity in technical hypothesis path effect sizes was partially explained by inter- and intra-personal moderators. Conclusions This meta-analysis provides additional support for the technical hypothesis of MI efficacy; future research on the relational hypothesis should occur in the field rather than in the context of clinical trials. PMID:29265832

A meta-analysis of motivational interviewing process: Technical, relational, and conditional process models of change.

PubMed

Magill, Molly; Apodaca, Timothy R; Borsari, Brian; Gaume, Jacques; Hoadley, Ariel; Gordon, Rebecca E F; Tonigan, J Scott; Moyers, Theresa

2018-02-01

In the present meta-analysis, we test the technical and relational hypotheses of Motivational Interviewing (MI) efficacy. We also propose an a priori conditional process model where heterogeneity of technical path effect sizes should be explained by interpersonal/relational (i.e., empathy, MI Spirit) and intrapersonal (i.e., client treatment seeking status) moderators. A systematic review identified k = 58 reports, describing 36 primary studies and 40 effect sizes (N = 3,025 participants). Statistical methods calculated the inverse variance-weighted pooled correlation coefficient for the therapist to client and the client to outcome paths across multiple target behaviors (i.e., alcohol use, other drug use, other behavior change). Therapist MI-consistent skills were correlated with more client change talk (r = .55, p < .001) as well as more sustain talk (r = .40, p < .001). MI-inconsistent skills were correlated with more sustain talk (r = .16, p < .001), but not change talk. When these indicators were combined into proportions, as recommended in the Motivational Interviewing Skill Code, the overall technical hypothesis was supported. Specifically, proportion MI consistency was related to higher proportion change talk (r = .11, p = .004) and higher proportion change talk was related to reductions in risk behavior at follow up (r = -.16, p < .001). When tested as two independent effects, client change talk was not significant, but sustain talk was positively associated with worse outcome (r = .19, p < .001). Finally, the relational hypothesis was not supported, but heterogeneity in technical hypothesis path effect sizes was partially explained by inter- and intrapersonal moderators. This meta-analysis provides additional support for the technical hypothesis of MI efficacy; future research on the relational hypothesis should occur in the field rather than in the context of clinical trials. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Experimental study of turbulent flow heat transfer and pressure drop in plate heat exchanger with chevron plates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muley, A.; Manglik, R.M.

1999-02-01

Experimental heat transfer and isothermal pressure drop data for single-phase water flows in a plate heat exchanger (PHE) with chevron plates are presented. In a single-pass U-type counterflow PHE, three different chevron plate arrangements are considered: two symmetric plate arrangements with {beta} = 30 deg/30 deg and 60 deg/60 deg, and one mixed-plate arrangement with {beta} = 30 deg/60 deg. For water (2 < Pr < 6) flow rates in the 600 < Re < 10{sup 4} regime, data for Nu and f are presented. The results show significant effects of both the chevron angle {beta} and surface area enlargementmore » factor {phi}. As {beta} increases, and compared to a flat-plate pack, up to two to five times higher Nu are obtained; the concomitant f, however, are 13 to 44 times higher. Increasing {phi} also has a similar, though smaller effect. Based on experimental data for Re {ge} 1000 and 30 deg {le} {beta} {le} 60 deg, predictive correlations of the form Nu = C{sub 1}({beta}) D{sub 1}({phi}) Re{sup p1({beta})} Pr{sup 1/3} ({mu}/{mu}{sub w}){sup 0.14} and f = C{sub 2}({beta}) D{sub 2}({phi}) Re{sup p2({beta})} are devised. Finally, at constant pumping power, and depending upon Re, {beta}, and {phi}, the heat transfer is found to be enhanced by up to 2.8 times that in an equivalent flat-plate channel.« less

Assessment of the Central Effects of Natural Uranium via Behavioural Performances and the Cerebrospinal Fluid Metabolome

PubMed Central

Lestaevel, P.; Grison, S.; Favé, G.; Elie, C.; Dhieux, B.; Martin, J. C.; Tack, K.; Souidi, M.

2016-01-01

Natural uranium (NU), a component of the earth's crust, is not only a heavy metal but also an alpha particle emitter, with chemical and radiological toxicity. Populations may therefore be chronically exposed to NU through drinking water and food. Since the central nervous system is known to be sensitive to pollutants during its development, we assessed the effects on the behaviour and the cerebrospinal fluid (CSF) metabolome of rats exposed for 9 months from birth to NU via lactation and drinking water (1.5, 10, or 40 mg·L−1 for male rats and 40 mg·L−1 for female rats). Medium-term memory decreased in comparison to controls in male rats exposed to 1.5, 10, or 40 mg·L−1 NU. In male rats, spatial working memory and anxiety- and depressive-like behaviour were only altered by exposure to 40 mg·L−1 NU and any significant effect was observed on locomotor activity. In female rats exposed to NU, only locomotor activity was significantly increased in comparison with controls. LC-MS metabolomics of CSF discriminated the fingerprints of the male and/or female NU-exposed and control groups. This study suggests that exposure to environmental doses of NU from development to adulthood can have an impact on rat brain function. PMID:27247806

Assessment of the Central Effects of Natural Uranium via Behavioural Performances and the Cerebrospinal Fluid Metabolome.

PubMed

Lestaevel, P; Grison, S; Favé, G; Elie, C; Dhieux, B; Martin, J C; Tack, K; Souidi, M

2016-01-01

Natural uranium (NU), a component of the earth's crust, is not only a heavy metal but also an alpha particle emitter, with chemical and radiological toxicity. Populations may therefore be chronically exposed to NU through drinking water and food. Since the central nervous system is known to be sensitive to pollutants during its development, we assessed the effects on the behaviour and the cerebrospinal fluid (CSF) metabolome of rats exposed for 9 months from birth to NU via lactation and drinking water (1.5, 10, or 40 mg·L(-1) for male rats and 40 mg·L(-1) for female rats). Medium-term memory decreased in comparison to controls in male rats exposed to 1.5, 10, or 40 mg·L(-1) NU. In male rats, spatial working memory and anxiety- and depressive-like behaviour were only altered by exposure to 40 mg·L(-1) NU and any significant effect was observed on locomotor activity. In female rats exposed to NU, only locomotor activity was significantly increased in comparison with controls. LC-MS metabolomics of CSF discriminated the fingerprints of the male and/or female NU-exposed and control groups. This study suggests that exposure to environmental doses of NU from development to adulthood can have an impact on rat brain function.

Line parameters of methanol (CH3OH) at 10 microns

NASA Astrophysics Data System (ADS)

Lees, R. M.; Xu, L.-H.; Wang, P.; Brown, L. R.; Kleiner, I.; Johns, J. W. C.

2003-05-01

Laboratory spectra of methanol have been measured at high resolution and analyzed to provide spectroscopic information required for astrophysics and solar system studies. Line positions and quantum assignments have been obtained using spectra recorded at 0.002 cm-1 resolution using a modified Bomem DA3,002 spectrometer. Line intensities have been retrieved using laboratory scans from the McMath-Pierce Fourier-transform spectrometer located at the National Solar Observatory. The 10 micron region methanol absorption arises mainly from the fundamental CO-stretch mode (nu8) at 1033 cm-1, along with occasional transitions perturbed in the region by several nearby interacting states of the methyl rock (nu7), methyl bends (nu5, nu10, nu4) and the OH-bending (nu6) in combination with the torsion (nu12). Overall, the nu8 CO-stretch mode follows the traditional torsion-rotational pattern. We modeled the line positions and intensities for the CO-stretch mode with the one-dimensional torsional Hamiltonian and produced a HITRAN line list for cometary studies. The research described in this paper was carried out by the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration. RML and LHXu wish to acknowledge financial support from the Natural Sciences and Engineering Research Council of Canada. IK would like to thank the French Programme National de Planétologie (PNP) for funding this research.

Rachiplusia nu larva as a biofactory to achieve high level expression of horseradish peroxidase.

PubMed

Romero, Lucía Virginia; Targovnik, Alexandra Marisa; Wolman, Federico Javier; Cascone, Osvaldo; Miranda, María Victoria

2011-05-01

A process based on orally-infected Rachiplusia nu larvae as biological factories for expression and one-step purification of horseradish peroxidase isozyme C (HRP-C) is described. The process allows obtaining high levels of pure HRP-C by membrane chromatography purification. The introduction of the partial polyhedrin homology sequence element in the target gene increased HRP-C expression level by 2.8-fold whereas it increased 1.8-fold when the larvae were reared at 27 °C instead of at 24 °C, summing up a 4.6-fold overall increase in the expression level. Additionally, HRP-C purification by membrane chromatography at a high flow rate greatly increase D the productivity without affecting the resolution. The V(max) and K(m) values of the recombinant HRP-C were similar to those of the HRP from Armoracia rusticana roots. © Springer Science+Business Media B.V. 2011

Measurement of neutrino flux from neutrino-electron elastic scattering

DOE PAGES

Park, J.; Aliaga, L.; Altinok, O.; ...

2016-06-10

Muon-neutrino elastic scattering on electrons is an observable neutrino process whose cross section is precisely known. Consequently, a measurement of this process in an accelerator-based ν μ beam can improve the knowledge of the absolute neutrino flux impinging upon the detector; typically this knowledge is limited to ~10% due to uncertainties in hadron production and focusing. We also isolated a sample of 135±17 neutrino-electron elastic scattering candidates in the segmented scintillator detector of MINERvA, after subtracting backgrounds and correcting for efficiency. We show how this sample can be used to reduce the total uncertainty on the NuMI ν μ fluxmore » from 9% to 6%. Finally, our measurement provides a flux constraint that is useful to other experiments using the NuMI beam, and this technique is applicable to future neutrino beams operating at multi-GeV energies.« less

Measurement of neutrino flux from neutrino-electron elastic scattering

NASA Astrophysics Data System (ADS)

Park, J.; Aliaga, L.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Budd, H.; Cai, T.; Carneiro, M. F.; Christy, M. E.; Chvojka, J.; da Motta, H.; Dytman, S. A.; Díaz, G. A.; Eberly, B.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Kleykamp, J.; Kordosky, M.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Marshall, C. M.; Martinez Caicedo, D. A.; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Mousseau, J.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman; Osta, J.; Paolone, V.; Patrick, C. E.; Perdue, G. N.; Rakotondravohitra, L.; Ramirez, M. A.; Ray, H.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schellman, H.; Solano Salinas, C. J.; Tagg, N.; Tice, B. G.; Valencia, E.; Walton, T.; Wolcott, J.; Wospakrik, M.; Zavala, G.; Zhang, D.; Miner ν A Collaboration

2016-06-01

Muon-neutrino elastic scattering on electrons is an observable neutrino process whose cross section is precisely known. Consequently a measurement of this process in an accelerator-based νμ beam can improve the knowledge of the absolute neutrino flux impinging upon the detector; typically this knowledge is limited to ˜10 % due to uncertainties in hadron production and focusing. We have isolated a sample of 135 ±17 neutrino-electron elastic scattering candidates in the segmented scintillator detector of MINERvA, after subtracting backgrounds and correcting for efficiency. We show how this sample can be used to reduce the total uncertainty on the NuMI νμ flux from 9% to 6%. Our measurement provides a flux constraint that is useful to other experiments using the NuMI beam, and this technique is applicable to future neutrino beams operating at multi-GeV energies.

The Rhythm of Fairall 9. I. Observing the Spectral Variability With XMM-Newton and NuSTAR

NASA Technical Reports Server (NTRS)

Lohfink, A. M.; Reynolds, S. C.; Pinto, C.; Alston, W.; Boggs, S. E.; Christensen, F. E.; Craig, W. W.; Fabian, A.C; Hailey, C. J.; Harrison, F. A.;

KSC-2012-1268

NASA Image and Video Library

2012-02-06

VANDENBERG AIR FORCE BASE, Calif. – In an environmental enclosure in processing facility 1555 at Vandenberg Air Force Base in California, twin segments of a Pegasus payload fairing for NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) mission are cleaned and inspected before the spacecraft is encapsulated. The fairing will protect the spacecraft from the heat and aerodynamic pressure generated during ascent to orbit aboard an Orbital Sciences Pegasus XL rocket in March. Once processing of the rocket and spacecraft are completed at Vandenberg, they will be flown aboard an L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site on the Pacific Ocean’s Kwajalein Atoll for launch. NuSTAR, a high-energy x-ray telescope, will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1267

NASA Image and Video Library

2012-02-06

VANDENBERG AIR FORCE BASE, Calif. – In an environmental enclosure in processing facility 1555 at Vandenberg Air Force Base in California, cleaning and inspection of half of a Pegasus payload fairing for NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) mission is under way. The fairing will protect the spacecraft from the heat and aerodynamic pressure generated during ascent to orbit aboard an Orbital Sciences Pegasus XL rocket in March. Once processing of the rocket and spacecraft are completed at Vandenberg, they will be flown aboard an L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site on the Pacific Ocean’s Kwajalein Atoll for launch. NuSTAR, a high-energy x-ray telescope, will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1528

NASA Image and Video Library

2012-02-17

VANDENBERG AIR FORCE BASE, Calif. – Inside an environmental enclosure at Vandenberg Air Force Base's processing facility in California, solar panels line the sides of NASA's Nuclear Spectroscopic Telescope Array, or NuSTAR, spacecraft. NuSTAR is newly mated with its Orbital Sciences Pegasus XL rocket. The uniting of the spacecraft with the rocket is a major milestone in prelaunch preparations. After processing of the rocket and spacecraft are complete, they will be flown on Orbital's L-1011 carrier aircraft from Vandenberg to the Ronald Reagan Ballistic Missile Defense Test Site on the Pacific Ocean’s Kwajalein Atoll for launch. The high-energy x-ray telescope will conduct a census of black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1269

NASA Image and Video Library

2012-02-06

VANDENBERG AIR FORCE BASE, Calif. – In processing facility 1555 at Vandenberg Air Force Base in California, segments of a Pegasus payload fairing for NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) mission have been cleaned and inspected, a milestone in launch preparations. The fairing will protect the spacecraft from the heat and aerodynamic pressure generated during ascent to orbit aboard an Orbital Sciences Pegasus XL rocket in March. Once processing of the rocket and spacecraft are completed at Vandenberg, they will be flown aboard an L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site on the Pacific Ocean’s Kwajalein Atoll for launch. NuSTAR, a high-energy x-ray telescope, will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

Development and validation of a 2D dam break process model

USDA-ARS?s Scientific Manuscript database

Flooding due to dam or levee breach often results in detrimental impact on the people and their properties in the flooding zone. The embankment breach process is often caused by overtopping or internal erosion due to excessive water in a reservoir or a river. This study is to develop a practical nu...

The Big Glitcher - the Rotation History of PSR JO537-6910

NASA Technical Reports Server (NTRS)

Marshall, F. E.; Gotthelf, E. V.; Middleditch, J.; Wang, Q. D.; Zhang, W.

2003-01-01

We report the results of an extensive monitoring campaign of PSR 50537-6910, the 16 ms pulsar in the Large Magellanic Cloud, using data acquired with the Rossi X-ray Timing Explorer. The spin evolution of this pulsar is found to experience extreme episodic discontinuities in its spin-down rate during the 2.6 year campaign. The rate of occurance of these timing glitches is 2.3 per year, comparable to the highest seen for any pulsar. The mean glitch amplitude produced a fraction change in the frequency of Delta(nu)/nu = 0.36 x l0(exp -6) and in the frequency derivative of Delta(dot nu)/dot nu = 3 x 10(exp -4). Despite this prodigous timing activity we are able to derive a phase connected timing solution between glitch events with an average spin-down rate of -1.9743 x 10(exp 10) Hz/s. The integrated effect of the glitches in dot nu was so large that the apparent characteristic age of the pulsar (-nu/2dot nu) decreased significantly during the campaign. We discuss the implications of a large glitch activity and high braking index on the spin evolution of young pulsars.

Introducing Multisensor Satellite Radiance-Based Evaluation for Regional Earth System Modeling

NASA Technical Reports Server (NTRS)

Matsui, T.; Santanello, J.; Shi, J. J.; Tao, W.-K.; Wu, D.; Peters-Lidard, C.; Kemp, E.; Chin, M.; Starr, D.; Sekiguchi, M.;

pH-dependent ammonia removal pathways in microbial fuel cell system.

PubMed

Kim, Taeyoung; An, Junyeong; Lee, Hyeryeong; Jang, Jae Kyung; Chang, In Seop

2016-09-01

In this work, ammonia removal paths in microbial fuel cells (MFCs) under different initial pH conditions (pH 7.0, 8.0, and 8.6) were investigated. At a neutral pH condition (pH 7.0), MFC used an electrical energy of 27.4% and removed 23.3% of total ammonia by electrochemical pathway for 192h. At the identical pH condition, 36.1% of the total ammonia was also removed by the biological path suspected to be biological ammonia oxidation process (e.g., Anammox). With the initial pH increased, the electrochemical removal efficiency decreased to less than 5.0%, while the biological removal efficiency highly increased to 61.8%. In this study, a neutral pH should be maintained in the anode to utilize MFCs for ammonia recovery via electrochemical pathways from wastewater stream. Copyright © 2016 Elsevier Ltd. All rights reserved.

NuSTAR on-ground calibration: II. Effective area

NASA Astrophysics Data System (ADS)

Brejnholt, Nicolai F.; Christensen, Finn E.; Westergaard, Niels J.; Hailey, Charles J.; Koglin, Jason E.; Craig, William W.

2012-09-01

The Nuclear Spectroscopic Telescope ARray (NuSTAR) was launched in June 2012 carrying the first focusing hard X-ray (5-80keV) optics to orbit. The multilayer coating was carried out at the Technical University of Denmark (DTU Space). In this article we introduce the NuSTAR multilayer reference database and its implementation in the NuSTAR optic response model. The database and its implementation is validated using on-ground effective area calibration data and used to estimate in-orbit performance.

Behavioral vs. molecular sources of conflict between nuclear and mitochondrial DNA: The role of male-biased dispersal in a Holarctic sea duck

USGS Publications Warehouse

Peters, Jeffrey L.; Bolender, Kimberly A.; Pearce, John M.

2012-01-01

Genetic studies of waterfowl (Anatidae) have observed the full spectrum of mitochondrial (mt) DNA population divergence, from apparent panmixia to deep, reciprocally monophyletic lineages. Yet, these studies often found weak or no nuclear (nu) DNA structure, which was often attributed to male-biased gene flow, a common behaviour within this family. An alternative explanation for this ‘conflict’ is that the smaller effective population size and faster sorting rate of mtDNA relative to nuDNA lead to different signals of population structure. We tested these alternatives by sequencing 12 nuDNA introns for a Holarctic pair of waterfowl subspecies, the European goosander (Mergus merganser merganser) and the North American common merganser (M. m. americanus), which exhibit strong population structure in mtDNA. We inferred effective population sizes, gene flow and divergence times from published mtDNA sequences and simulated expected differentiation for nuDNA based on those histories. Between Europe and North America, nuDNA ФST was 3.4-fold lower than mtDNA ФST, a result consistent with differences in sorting rates. However, despite geographically structured and monophyletic mtDNA lineages within continents, nuDNA ФST values were generally zero and significantly lower than predicted. This between- and within-continent contrast held when comparing mtDNA and nuDNA among published studies of ducks. Thus, male-mediated gene flow is a better explanation than slower sorting rates for limited nuDNA differentiation within continents, which is also supported by nonmolecular data. This study illustrates the value of quantitatively testing discrepancies between mtDNA and nuDNA to reject the null hypothesis that conflict simply reflects different sorting rates.

DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.

PubMed

Dolman, M Emmy M; van der Ploeg, Ida; Koster, Jan; Bate-Eya, Laurel Tabe; Versteeg, Rogier; Caron, Huib N; Molenaar, Jan J

2015-01-01

Tumor cells might resist therapy with ionizing radiation (IR) by non-homologous end-joining (NHEJ) of IR-induced double-strand breaks. One of the key players in NHEJ is DNA-dependent protein kinase (DNA-PK). The catalytic subunit of DNA-PK, i.e. DNA-PKcs, can be inhibited with the small-molecule inhibitor NU7026. In the current study, the in vitro potential of NU7026 to radiosensitize neuroblastoma cells was investigated. DNA-PKcs is encoded by the PRKDC (protein kinase, DNA-activated, catalytic polypeptide) gene. We showed that PRKDC levels were enhanced in neuroblastoma patients and correlated with a more advanced tumor stage and poor prognosis, making DNA-PKcs an interesting target for radiosensitization of neuroblastoma tumors. Optimal dose finding for combination treatment with NU7026 and IR was performed using NGP cells. One hour pre-treatment with 10 μM NU7026 synergistically sensitized NGP cells to 0.63 Gy IR. Radiosensitizing effects of NU7026 increased in time, with maximum effects observed from 96 h after IR-exposure on. Combined treatment of NGP cells with 10 μM NU7026 and 0.63 Gy IR resulted in apoptosis, while no apoptotic response was observed for either of the therapies alone. Inhibition of IR-induced DNA-PK activation by NU7026 confirmed the capability of NGP cells to, at least partially, resist IR by NHEJ. NU7026 also synergistically radiosensitized other neuroblastoma cell lines, while no synergistic effect was observed for low DNA-PKcs-expressing non-cancerous fibroblasts. Results obtained for NU7026 were confirmed by PRKDC knockdown in NGP cells. Taken together, the current study shows that DNA-PKcs is a promising target for neuroblastoma radiosensitization.

CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn.

PubMed

Harashima, Akira; Suzuki, Motoyuki; Okochi, Ayumi; Yamamoto, Mayuko; Matsuo, Yoshinobu; Motoda, Ryuichi; Yoshioka, Tamotsu; Orita, Kunzo

2002-12-15

CD45 is a membrane-associated tyrosine phosphatase that dephosphorylates Src family kinases and Janus kinases (JAKs). To clarify the role of CD45 in hematopoietic differentiation, we examined the effects of anti-CD45 monoclonal antibody NU-L(PAN) on the proliferation and differentiation of umbilical cord blood CD34(+) cells. NU-L(PAN) showed a prominent inhibition of the proliferation of CD34(+) cells induced by the mouse bone marrow stromal cell line MS-5 or erythropoietin (EPO). However, NU-L(PAN) did not affect the proliferation induced by interleukin 3. NU-L(PAN) also inhibited MS-5-induced or EPO-induced erythroid differentiation of CD34(+) cells. The cells stimulated with EPO in the presence of NU-L(PAN) morphologically showed differentiation arrest at the stage of basophilic erythroblasts after 11 days of culture, whereas the cells treated with EPO without NU-L(PAN) differentiated into mature red blood cells. The Src family kinase Lyn and JAK2 were phosphorylated when erythroblasts obtained after 4 days of culture of CD34(+) cells in the presence of EPO were restimulated with EPO. Overnight NU-L(PAN) treatment before addition of EPO reduced the phosphorylation of Lyn but not that of JAK2. Simultaneously, the enhancement of Lyn kinase activity after restimulation with EPO was reduced by NU-L(PAN) treatment. These results indicate selective inactivation of Lyn by CD45 activated with NU-L(PAN) and could partly explain the inhibitory mechanism on erythropoiesis exhibited by EPO. These findings suggest that CD45 may play a pivotal role in erythropoiesis.

DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells

PubMed Central

Dolman, M. Emmy M.; van der Ploeg, Ida; Koster, Jan; Bate-Eya, Laurel Tabe; Versteeg, Rogier; Caron, Huib N.; Molenaar, Jan J.

2015-01-01

Tumor cells might resist therapy with ionizing radiation (IR) by non-homologous end-joining (NHEJ) of IR-induced double-strand breaks. One of the key players in NHEJ is DNA-dependent protein kinase (DNA-PK). The catalytic subunit of DNA-PK, i.e. DNA-PKcs, can be inhibited with the small-molecule inhibitor NU7026. In the current study, the in vitro potential of NU7026 to radiosensitize neuroblastoma cells was investigated. DNA-PKcs is encoded by the PRKDC (protein kinase, DNA-activated, catalytic polypeptide) gene. We showed that PRKDC levels were enhanced in neuroblastoma patients and correlated with a more advanced tumor stage and poor prognosis, making DNA-PKcs an interesting target for radiosensitization of neuroblastoma tumors. Optimal dose finding for combination treatment with NU7026 and IR was performed using NGP cells. One hour pre-treatment with 10 μM NU7026 synergistically sensitized NGP cells to 0.63 Gy IR. Radiosensitizing effects of NU7026 increased in time, with maximum effects observed from 96 h after IR-exposure on. Combined treatment of NGP cells with 10 μM NU7026 and 0.63 Gy IR resulted in apoptosis, while no apoptotic response was observed for either of the therapies alone. Inhibition of IR-induced DNA-PK activation by NU7026 confirmed the capability of NGP cells to, at least partially, resist IR by NHEJ. NU7026 also synergistically radiosensitized other neuroblastoma cell lines, while no synergistic effect was observed for low DNA-PKcs-expressing non-cancerous fibroblasts. Results obtained for NU7026 were confirmed by PRKDC knockdown in NGP cells. Taken together, the current study shows that DNA-PKcs is a promising target for neuroblastoma radiosensitization. PMID:26716839

Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.

PubMed

Yang, Tao; Jian, Wei; Luo, Yi; Fu, Xueqi; Noguchi, Constance; Bungert, Jörg; Huang, Suming; Qiu, Yi

2012-11-23

HDAC1-containing NuRD complex is required for GATA-1-mediated repression and activation. GATA-1 associated with acetylated HDAC1-containing NuRD complex, which has no deacetylase activity, for gene activation. Acetylated HDAC1 converts NuRD complex from a repressor to an activator during GATA-1-directed erythroid differentiation program. HDAC1 acetylation may function as a master regulator for the activity of HDAC1 containing complexes. Histone deacetylases (HDACs) play important roles in regulating cell proliferation and differentiation. The HDAC1-containing NuRD complex is generally considered as a corepressor complex and is required for GATA-1-mediated repression. However, recent studies also show that the NuRD complex is involved in GATA-1-mediated gene activation. We tested whether the GATA-1-associated NuRD complex loses its deacetylase activity and commits the GATA-1 complex to become an activator during erythropoiesis. We found that GATA-1-associated deacetylase activity gradually decreased upon induction of erythroid differentiation. GATA-1-associated HDAC1 is increasingly acetylated after differentiation. It has been demonstrated earlier that acetylated HDAC1 has no deacetylase activity. Indeed, overexpression of an HDAC1 mutant, which mimics acetylated HDAC1, promotes GATA-1-mediated transcription and erythroid differentiation. Furthermore, during erythroid differentiation, acetylated HDAC1 recruitment is increased at GATA-1-activated genes, whereas it is significantly decreased at GATA-1-repressed genes. Interestingly, deacetylase activity is not required for Mi2 remodeling activity, suggesting that remodeling activity may be required for both activation and repression. Thus, our data suggest that NuRD can function as a coactivator or repressor and that acetylated HDAC1 converts the NuRD complex from a repressor to an activator during GATA-1-directed erythroid differentiation.

5-10 GeV neutrinos from gamma-Ray burst fireballs

PubMed

Bahcall; Meszaros

2000-08-14

A gamma-ray burst fireball is likely to contain an admixture of neutrons. Inelastic collisions between differentially streaming protons and neutrons in the fireball produce nu(&mgr;) (nu;(&mgr;)) of approximately 10 GeV as well as nu(e) (nu;(e)) of approximately 5 GeV, which could produce approximately 7 events/year in km(3) detectors, if the neutron abundance is comparable to that of protons. Photons of approximately 10 GeV from pi(0) decay and approximately 100 MeV nu;(e) from neutron decay are also produced, but will be difficult to detect. Photons with energies less, similar1 MeV from shocks following neutron decay produce a characteristic signal which may be distinguishable from the proton-related MeV photons.

Measurements of B --> {pi,eta,eta;{'}}lnu_{l} branching fractions and determination of |V_{ub}| with semileptonically tagged B mesons.

PubMed

Aubert, B; Bona, M; Karyotakis, Y; Lees, J P; Poireau, V; Prencipe, E; Prudent, X; Tisserand, V; Garra Tico, J; Grauges, E; Lopez, L; Palano, A; Pappagallo, M; Eigen, G; Stugu, B; Sun, L; Abrams, G S; Battaglia, M; Brown, D N; Cahn, R N; Jacobsen, R G; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Osipenkov, I L; Ronan, M T; Tackmann, K; Tanabe, T; Hawkes, C M; Soni, N; Watson, A T; Koch, H; Schroeder, T; Walker, D; Asgeirsson, D J; Cuhadar-Donszelmann, T; Fulsom, B G; Hearty, C; Mattison, T S; McKenna, J A; Barrett, M; Khan, A; Teodorescu, L; Blinov, V E; Bukin, A D; Buzykaev, A R; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Martin, E C; Stoker, D P; Abachi, S; Buchanan, C; Gary, J W; Liu, F; Long, O; Shen, B C; Vitug, G M; Yasin, Z; Zhang, L; Sharma, V; Campagnari, C; Hong, T M; Kovalskyi, D; Mazur, M A; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Schalk, T; Schumm, B A; Seiden, A; Wang, L; Wilson, M G; Winstrom, L O; Cheng, C H; Doll, D A; Echenard, B; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Andreassen, R; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Ford, W T; Gaz, A; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Smith, J G; Ulmer, K A; Wagner, S R; Ayad, R; Soffer, A; Toki, W H; Wilson, R J; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Karbach, M; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Kobel, M J; Mader, W F; Nogowski, R; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Thiebaux, Ch; Verderi, M; Clark, P J; Gradl, W; Playfer, S; Watson, J E; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Franchini, P; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Santoro, V; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Chaisanguanthum, K S; Morii, M; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Klose, V; Lacker, H M; De Nardo, G; Lista, L; Monorchio, D; Onorato, G; Sciacca, C; Bard, D J; Dauncey, P D; Nash, J A; Panduro Vazquez, W; Tibbetts, M; Behera, P K; Chai, X; Charles, M J; Mallik, U; Cochran, J; Crawley, H B; Dong, L; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gao, Y Y; Gritsan, A V; Guo, Z J; Lae, C K; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Béquilleux, J; D'Orazio, A; Davier, M; Firmino da Costa, J; Grosdidier, G; Höcker, A; Lepeltier, V; Le Diberder, F; Lutz, A M; Pruvot, S; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wormser, G; Lange, D J; Wright, D M; Bingham, I; Burke, J P; Chavez, C A; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Touramanis, C; Bevan, A J; George, K A; Di Lodovico, F; Sacco, R; Sigamani, M; Cowan, G; Flaecher, H U; Hopkins, D A; Paramesvaran, S; Salvatore, F; Wren, A C; Brown, D N; Davis, C L; Alwyn, K E; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; West, T J; Yi, J I; Anderson, J; Chen, C; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Dallapiccola, C; Hertzbach, S S; Li, X; Salvati, E; Saremi, S; Cowan, R; Dujmic, D; Fisher, P H; Koeneke, K; Sciolla, G; Spitznagel, M; Taylor, F; Yamamoto, R K; Zhao, M; McLachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; Knoepfel, K J; Losecco, J M; Wang, W F; Benelli, G; Corwin, L A; Honscheid, K; Kagan, H; Kass, R; Morris, J P; Rahimi, A M; Regensburger, J J; Sekula, S J; Wong, Q K; Blount, N L; Brau, J; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Castelli, G; Gagliardi, N; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Del Amo Sanchez, P; Ben-Haim, E; Briand, H; Calderini, G; Chauveau, J; David, P; Del Buono, L; Hamon, O; Leruste, Ph; Ocariz, J; Perez, A; Prendki, J; Gladney, L; Biasini, M; Covarelli, R; Manoni, E; Angelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Biesiada, J; Lopes Pegna, D; Lu, C; Olsen, J; Smith, A J S; Telnov, A V; Anulli, F; Baracchini, E; Cavoto, G; Del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, P D; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Renga, F; Voena, C; Ebert, M; Hartmann, T; Schröder, H; Waldi, R; Adye, T; Franek, B; Olaiya, E O; Roethel, W; Wilson, F F; Emery, S; Escalier, M; Esteve, L; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, W; Vasseur, G; Yèche, Ch; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; White, R M; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Benitez, J F; Cenci, R; Coleman, J P; Convery, M R; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Field, R C; Gabareen, A M; Gowdy, S J; Graham, M T; Grenier, P; Hast, C; Innes, W R; Kaminski, J; Kelsey, M H; Kim, H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Lindquist, B; Luitz, S; Luth, V; Lynch, H L; Macfarlane, D B; Marsiske, H; Messner, R; Muller, D R; Neal, H; Nelson, S; O'Grady, C P; Ofte, I; Perazzo, A; Perl, M; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Va'vra, J; Wagner, A P; Weaver, M; West, C A; Wisniewski, W J; Wittgen, M; Wright, D H; Wulsin, H W; Yarritu, A K; Yi, K; Young, C C; Ziegler, V; Burchat, P R; Edwards, A J; Majewski, S A; Miyashita, T S; Petersen, B A; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Pan, B; Saeed, M A; Zain, S B; Spanier, S M; Wogsland, B J; Eckmann, R; Ritchie, J L; Ruland, A M; Schilling, C J; Schwitters, R F; Drummond, B W; Izen, J M; Lou, X C; Bianchi, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martinez-Vidal, F; Milanes, D A; Oyanguren, A; Albert, J; Banerjee, Sw; Bhuyan, B; Choi, H H F; Hamano, K; Kowalewski, R; Lewczuk, M J; Nugent, I M; Roney, J M; Sobie, R J; Gershon, T J; Harrison, P F; Ilic, J; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Dasu, S; Flood, K T; Pan, Y; Pierini, M; Prepost, R; Vuosalo, C O; Wu, S L

2008-08-22

We report measurements of branching fractions for the decays B-->Plnu_{l}, where P are the pseudoscalar charmless mesons pi;{-}, pi;{0}, eta and eta;{'}, based on 348 fb;{-1} of data collected with the BABAR detector, using B0 and B+ mesons found in the recoil of a second B meson decaying as B-->D;{(*)}lnu_{l}. Assuming isospin symmetry, we combine pionic branching fractions to obtain B(B;{0}-->pi;{-}l;{+}nu_{l})=(1.54+/-0.17_{(stat)}+/-0.09_{(syst)})x10;{-4}; we find 3.2sigma evidence of the decay B;{+}-->etal;{+}nu_{l} and measure its branching fraction to be (0.64+/-0.20_{(stat)}+/-0.03_{(syst)})x10;{-4}, and determine B(B;{+}-->eta;{'}l;{+}nu_{l})<0.47x10;{-4} to 90% confidence level. Using partial branching fractions for the pionic decays in ranges of the momentum transfer and a variety of form factor calculation, we obtain values of the magnitude of the Cabibbo-Kobayashi-Maskawa matrix element |V_{ub}| in ranging from 3.6x10;{-3} to 4.1x10;{-3}.

New insight into the shape coexistence and shape evolution of {sup 157}Yb

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, C.; Hua, H.; Li, X. Q.

2011-01-15

High-spin states in {sup 157}Yb have been populated in the {sup 144}Sm({sup 16}O,3n){sup 157}Yb fusion-evaporation reaction at a beam energy of 85 MeV. Two rotational bands built on the {nu}f{sub 7/2} and {nu}h{sub 9/2} intrinsic states, respectively, have been established for the first time. The newly observed {nu}f{sub 7/2} band and previously known {nu}i{sub 13/2} band in {sup 157}Yb are discussed in terms of total Routhian surface methods and compared with the structures in the neighboring N = 87 isotones. The structural characters observed in {sup 157}Yb provide evidence for shape coexistence of three distinct shapes: prolate, triaxial, and oblate.more » At higher spins, both the {nu}f{sub 7/2} band and {nu}i{sub 13/2} band in {sup 157}Yb undergo a shape evolution with sizable alignments occurring.« less

Using NU-KNIT® for hemostasis around recurrent laryngeal nerve during transthoracic esophagectomy with lymphadenectomy for esophageal cancer.

PubMed

Rino, Yasushi; Yukawa, Norio; Sato, Tsutomu; Yamamoto, Naoto; Tamagawa, Hiroshi; Hasegawa, Shinichi; Oshima, Takashi; Yoshikawa, Takaki; Masuda, Munetaka; Imada, Toshio

2014-03-06

We thought that using electrocautery for hemostasis caused recurrent laryngeal nerve palsy. We reflected the prolonged use of electrocautery and employed NU-KNIT® to achieve hemostasis nearby the recurrent laryngeal nerve. We assessed that using NU-KNIT® hemostasis prevented or not postoperative recurrent laryngeal nerve palsy, retrospectively. The present study was evaluated to compare using electrocautery hemostasis with using NU-KNIT® hemostasis during lymphadenectomy along recurrent laryngeal nerve. The variables compared were morbidity rate of recurrent laryngeal nerve palsy, operation time, and blood loss. We use NU-KNIT® to achieve hemostasis without strong compression. This group is named group N. On the other hand, we use electrocautery to achieve hemostasis. This group is named group E. Complication rate of recurrent laryngeal nerve palsy was higher in group E (55.6%) than group N (5.3%) (p = 0.007). Even hemostasis using NU-KNIT® was slightly more time-consuming than using electrocautery, we concluded that it would be useful to prevent recurrent laryngeal nerve palsy.

Atomic layer deposition in a metal–organic framework: Synthesis, characterization, and performance of a solid acid

DOE PAGES

Rimoldi, Martino; Bernales, Varinia; Borycz, Joshua; ...

2017-01-05

NU-1000, a zirconium-based metal-organic framework featuring mesoporous channels, has been post-synthetically metalated via atomic layer deposition in MOF (AIM) employing dimethylaluminum iso-propoxide ([AlMe 2 iOPr] 2 – DMAI), a milder precursor than widely used trimethylaluminum (AlMe 3 - TMA). The aluminum-modified NU-1000 (Al-NU-1000) has been characterized with a comprehensive suite of techniques that points to the formation of aluminum oxide clusters well dispersed through the framework and stabilized by confinement within small pores intrinsic to the NU-1000 structure. Experimental evidence allows for identification of spectroscopic similarities between Al-NU-1000 and γ-Al 2O 3. Density functional theory modeling provides structures and simulatedmore » spectra the relevance of which can be assessed via comparison to experimental IR and EXAFS data. As a result, the catalytic performance of Al-NU-1000 has been benchmarked against γ-Al 2O 3, with promising results in terms of selectivity.« less

A Measurement of the t anti-t Cross Section in p anti-p Collisions at s**(1/2) = 1.96-TeV using Dilepton Events with a Lepton plus Track Selection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaltonen, T.; /Helsinki Inst. of Phys.; Adelman, Jahred A.

This paper reports a measurement of the cross section for the pair production of top quarks in p{bar p} collisions at {radical}s = 1.96 TeV at the Fermilab Tevatron. The data was collected from the CDF II detector in a set of runs with a total integrated luminosity of 1.1 fb{sup -1}. The cross section is measured in the dilepton channel, the subset of t{bar t} events in which both top quarks decay through t {yields} Wb {yields} {ell}{nu}b, where {ell} = e, {mu}, or {tau}. The lepton pair is reconstructed as one identified electron or muon and one isolatedmore » track. The use of an isolated track to identify the second lepton increases the t{bar t} acceptance, particularly for the case in which one W decays as W {yields} {tau}{nu}. The purity of the sample may be further improved at the cost of a reduction in the number of signal events, by requiring an identified b-jet. They present the results of measurements performed with and without the request of an identified b-jet. the former is the first published CDF result for which a b-jet requirement is added to the dilepton selection. In the CDF data there are 129 pretag lepton + track candidate events, of which 69 are tagged. With the tagging information, the sample is divided into tagged and untagged sub-samples, and a combined cross section is calculated by maximizing a likelihood. The result is {sigma}{sub t{bar t}} = 9.6 {+-} 1.2(stat.){sub -0.5}{sup +0.6}(sys.) {+-} 0.6(lum.) pb, assuming a branching ratio of BR(W {yields} {ell}{nu}) = 10.8% and a top mass of m{sub t} = 175 GeV/c{sup 2}.« less

Fourth standard model family neutrino at future linear colliders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ciftci, A.K.; Ciftci, R.; Sultansoy, S.

2005-09-01

It is known that flavor democracy favors the existence of the fourth standard model (SM) family. In order to give nonzero masses for the first three-family fermions flavor democracy has to be slightly broken. A parametrization for democracy breaking, which gives the correct values for fundamental fermion masses and, at the same time, predicts quark and lepton Cabibbo-Kobayashi-Maskawa (CKM) matrices in a good agreement with the experimental data, is proposed. The pair productions of the fourth SM family Dirac ({nu}{sub 4}) and Majorana (N{sub 1}) neutrinos at future linear colliders with {radical}(s)=500 GeV, 1 TeV, and 3 TeV are considered.more » The cross section for the process e{sup +}e{sup -}{yields}{nu}{sub 4}{nu}{sub 4}(N{sub 1}N{sub 1}) and the branching ratios for possible decay modes of the both neutrinos are determined. The decays of the fourth family neutrinos into muon channels ({nu}{sub 4}(N{sub 1}){yields}{mu}{sup {+-}}W{sup {+-}}) provide cleanest signature at e{sup +}e{sup -} colliders. Meanwhile, in our parametrization this channel is dominant. W bosons produced in decays of the fourth family neutrinos will be seen in detector as either di-jets or isolated leptons. As an example, we consider the production of 200 GeV mass fourth family neutrinos at {radical}(s)=500 GeV linear colliders by taking into account di-muon plus four jet events as signatures.« less

Correlated Photodissociation Dynamics of Small Molecules: Carbonyl Sulfide and Carbon Suboxide

NASA Astrophysics Data System (ADS)

Strauss, Charlie Elliott Murton

1990-01-01

The photodissociation of OCS and of C _3O_2 at 157.6 nm have been studied with full quantum state resolution of all fragments. Correlation of the independently measured fragment state distributions has been achieved without coincidence measurement via a maximum entropy method. For the experiments, dilute concentrations seeded in helium were expanded in a supersonic free jet, and the final state distribution of the CO, S, and C fragments were probed by tunable vacuum-ultraviolet laser induced fluorescence within 300 nanoseconds after photolysis by F_2 laser radiation. For OCS: Sulfur is produced almost entirely in its (^1S) state. Ground electronic state CO is produced in vibrational levels nu = 0 - 3 in the approximate ratio (1.0):(1.0):(0.5):(0.3). The rotational distribution for each vibrational level is nearly Boltzmann, with temperatures that decrease from 1350 K for nu = 0 to 780 K for nu = 3. CO Doppler profiles demonstrate that the absorption transition is of parallel character (beta = 1.8 +/- 0.2) and that the CO velocity and angular momentum vectors are perpendicular to one another. C_3O_2 dissociates into three fragments. Carbon is produced in its ^3P and ^1D states in the ratio (0.97):(0.03). CO is produced in vibrational levels nu = 0 - 4 in the ratio (0.57):(0.27):(0.1):(0.05):(<0.01). The rotational distributions are nearly Boltzmann with temperatures that increase from 3430 K for nu = 0 to 4670 K for nu = 2. Doppler profiles reveal the dissociation is nearly isotropic. The dissociation most likely proceeds in two steps via an intermediate electronically excited C_2O. A maximum likelihood method based upon information theory is developed to abstract the correlation between the final states for reactions of multiple independently measured fragment species. Methods for ascribing dynamical mechanisms to the inferred joint probability distribution are discussed. A 'decoupled' surprisal analysis technique appropriate to distributions coupled by conservation laws is presented. A figure-of-merit indicating whether a three body dissociation proceeds in one or two steps is invented. Application on a personal computer is made to the dissociations of acetone at 193 nm and C_3O _2 at 157.6 nm. The prior distribution for three fragments conserving momentum is derived.

DNA Barcoding Green Microalgae Isolated from Neotropical Inland Waters

PubMed Central

Hadi, Sámed I. I. A.; Santana, Hugo; Brunale, Patrícia P. M.; Gomes, Taísa G.; Oliveira, Márcia D.; Matthiensen, Alexandre; Oliveira, Marcos E. C.; Silva, Flávia C. P.; Brasil, Bruno S. A. F.

2016-01-01

This study evaluated the feasibility of using the Ribulose Bisphosphate Carboxylase Large subunit gene (rbcL) and the Internal Transcribed Spacers 1 and 2 of the nuclear rDNA (nuITS1 and nuITS2) markers for identifying a very diverse, albeit poorly known group, of green microalgae from neotropical inland waters. Fifty-one freshwater green microalgae strains isolated from Brazil, the largest biodiversity reservoir in the neotropics, were submitted to DNA barcoding. Currently available universal primers for ITS1-5.8S-ITS2 region amplification were sufficient to successfully amplify and sequence 47 (92%) of the samples. On the other hand, new sets of primers had to be designed for rbcL, which allowed 96% of the samples to be sequenced. Thirty-five percent of the strains could be unambiguously identified to the species level based either on nuITS1 or nuITS2 sequences’ using barcode gap calculations. nuITS2 Compensatory Base Change (CBC) and ITS1-5.8S-ITS2 region phylogenetic analysis, together with morphological inspection, confirmed the identification accuracy. In contrast, only 6% of the strains could be assigned to the correct species based solely on rbcL sequences. In conclusion, the data presented here indicates that either nuITS1 or nuITS2 are useful markers for DNA barcoding of freshwater green microalgae, with advantage for nuITS2 due to the larger availability of analytical tools and reference barcodes deposited at databases for this marker. PMID:26900844

Optimization of the magnetic horn for the nuSTORM non-conventional neutrino beam using the genetic algorithm

DOE PAGES

Liu, A.; Bross, A.; Neuffer, D.

2015-05-28

This paper describes the strategy for optimizing the magnetic horn for the neutrinos from STORed Muons (nuSTORM) facility. The nuSTORM magnetic horn is the primary collection device for the secondary particles generated by bombarding a solid target with 120 GeV protons. As a consequence of the non-conventional beamline designed for nuSTORM, the requirements on the horn are different from those for a conventional neutrino beamline. At nuSTORM, muons decay while circulating in the storage ring, and the detectors are placed downstream of the production straight so as to be exposed to the neutrinos from muon decay. nuSTORM aims at preciselymore » measuring the neutrino cross sections, and providing a definitive statement about the existence of sterile neutrinos. The nuSTORM horn aims at focusing the pions into a certain phase space so that more muons from pion decay can be accepted by the decay ring. The paper demonstrates a numerical method that was developed to optimize the horn design to gain higher neutrino flux from the circulating muons. A Genetic Algorithm (GA) was applied to the simultaneous optimization of the two objectives in this study. In conclusion, the application of the technique discussed in this paper is not limited to either the nuSTORM facility or muon based facilities, but can be used for other neutrino facilities that use magnetic horns as collection devices.« less

Nuclear Spectroscopic Telescope Array (NuSTAR) Mission

NASA Technical Reports Server (NTRS)

Kim, Yunjin; Willis, Jason; Dodd, Suzanne; Harrison, Fiona; Forster, Karl; Craig, William; Bester, Manfred; Oberg, David

2013-01-01

The Nuclear Spectroscopic Telescope Array (NuSTAR) is a National Aeronautics and Space Administration (NASA) Small Explorer mission that carried the first focusing hard X-ray (6-79 keV) telescope into orbit. It was launched on a Pegasus rocket into a low-inclination Earth orbit on June 13, 2012, from Reagan Test Site, Kwajalein Atoll. NuSTAR will carry out a two-year primary science mission. The NuSTAR observatory is composed of the X-ray instrument and the spacecraft. The NuSTAR spacecraft is three-axis stabilized with a single articulating solar array based on Orbital Sciences Corporation's LEOStar-2 design. The NuSTAR science instrument consists of two co-aligned grazing incidence optics focusing on to two shielded solid state CdZnTe pixel detectors. The instrument was launched in a compact, stowed configuration, and after launch, a 10-meter mast was deployed to achieve a focal length of 10.15 m. The NuSTAR instrument provides sub-arcminute imaging with excellent spectral resolution over a 12-arcminute field of view. The NuSTAR observatory will be operated out of the Mission Operations Center (MOC) at UC Berkeley. Most science targets will be viewed for a week or more. The science data will be transferred from the UC Berkeley MOC to a Science Operations Center (SOC) located at the California Institute of Technology (Caltech). In this paper, we will describe the mission architecture, the technical challenges during the development phase, and the post-launch activities.

Helioseismic Constraints on the Depth Dependence of Large-Scale Solar Convection

NASA Astrophysics Data System (ADS)

Woodard, Martin F.

2017-08-01

A recent helioseismic statistical waveform analysis of subsurface flow based on a 720-day time series of SOHO/MDI Medium-l spherical-harmonic coefficients has been extended to cover a greater range of subphotospheric depths. The latest analysis provides estimates of flow-dependent oscillation-mode coupling-strength coefficients b(s,t;n,l) over the range l = 30 to 150 of mode degree (angular wavenumber) for solar p-modes in the approximate frequency range 2 to 4 mHz. The range of penetration depths of this mode set covers most of the solar convection zone. The most recent analysis measures spherical harmonic (s,t) components of the flow velocity for odd s in the angular wavenumber range 1 to 19 for t not much smaller than s at a given s. The odd-s b(s,t;n,l) coefficients are interpreted as averages over depth of the depth-dependent amplitude of one spherical-harmonic (s,t) component of the toroidal part of the flow velocity field. The depth-dependent weighting function defining the average velocity is the fractional kinetic energy density in radius of modes of the (n,l) multiplet. The b coefficients have been converted to estimates of root velocity power as a function of l0 = nu0*l/nu(n,l), which is a measure of mode penetration depth. (nu(n,l) is mode frequency and nu0 is a reference frequency equal to 3 mHz.) A comparison of the observational results with simple convection models will be presented.

SOLAR PHOTOVOLTAIC AND WASTEWATER TREATMENT SYSTEMS DESIGN FOR COMMUNITIES IN PANAM&AACUTE;

EPA Science Inventory

In collaboration with the Panamanian non-governmental organization Centro de Estudios y Acción Social Panameño (CEASPA), the Northwestern University chapter of Engineers for a Sustainable World (ESW-NU) has been working with the rural ranching community of San...

Contrast-enhanced small-animal PET/CT in cancer research: strong improvement of diagnostic accuracy without significant alteration of quantitative accuracy and NEMA NU 4-2008 image quality parameters.

PubMed

Lasnon, Charline; Quak, Elske; Briand, Mélanie; Gu, Zheng; Louis, Marie-Hélène; Aide, Nicolas

2013-01-17

The use of iodinated contrast media in small-animal positron emission tomography (PET)/computed tomography (CT) could improve anatomic referencing and tumor delineation but may introduce inaccuracies in the attenuation correction of the PET images. This study evaluated the diagnostic performance and accuracy of quantitative values in contrast-enhanced small-animal PET/CT (CEPET/CT) as compared to unenhanced small animal PET/CT (UEPET/CT). Firstly, a NEMA NU 4-2008 phantom (filled with 18F-FDG or 18F-FDG plus contrast media) and a homemade phantom, mimicking an abdominal tumor surrounded by water or contrast media, were used to evaluate the impact of iodinated contrast media on the image quality parameters and accuracy of quantitative values for a pertinent-sized target. Secondly, two studies in 22 abdominal tumor-bearing mice and rats were performed. The first animal experiment studied the impact of a dual-contrast media protocol, comprising the intravenous injection of a long-lasting contrast agent mixed with 18F-FDG and the intraperitoneal injection of contrast media, on tumor delineation and the accuracy of quantitative values. The second animal experiment compared the diagnostic performance and quantitative values of CEPET/CT versus UEPET/CT by sacrificing the animals after the tracer uptake period and imaging them before and after intraperitoneal injection of contrast media. There was minimal impact on IQ parameters (%SDunif and spillover ratios in air and water) when the NEMA NU 4-2008 phantom was filled with 18F-FDG plus contrast media. In the homemade phantom, measured activity was similar to true activity (-0.02%) and overestimated by 10.30% when vials were surrounded by water or by an iodine solution, respectively. The first animal experiment showed excellent tumor delineation and a good correlation between small-animal (SA)-PET and ex vivo quantification (r2 = 0.87, P < 0.0001). The second animal experiment showed a good correlation between CEPET/CT and UEPET/CT quantitative values (r2 = 0.99, P < 0.0001). Receiver operating characteristic analysis demonstrated better diagnostic accuracy of CEPET/CT versus UEPET/CT (senior researcher, area under the curve (AUC) 0.96 versus 0.77, P = 0.004; junior researcher, AUC 0.78 versus 0.58, P = 0.004). The use of iodinated contrast media for small-animal PET imaging significantly improves tumor delineation and diagnostic performance, without significant alteration of SA-PET quantitative accuracy and NEMA NU 4-2008 IQ parameters.

Leptonic decays of charged D and Ds mesons

NASA Astrophysics Data System (ADS)

Menaa, Nabil

Using 281 pb--1 of data taken on the psi(3770) resonance and 314 pb--1 of data near or at 4170 MeV collected with the CLEO-c detector, we present two analyses to study the purely leptonic decays of charmed and charmed strange charged mesons. In the first analysis, we extract a relatively precise value for the decay constant of the D+ meson by measuring B (D+ → mu+nu) = (4.40 +/- 0.66+0.09-0.12 ) x 10-4. We find fD + = (222.6 +/- 16.7+2.8-3.4 ) MeV, and compare with current theoretical calculations. We also set a 90% confidence upper limit on B (D+ → e +nu) < 2.4 x 10-5 which constrains new physics models. Finally with this data sample, we test whether or not the tau lepton manifests the same couplings as the mu lepton by investigating the relative decay rates in purely leptonic D+ meson decays. We limit B (D+ → tau+nu) < 2.1 x 10--3 at 90% confidence level (C. L.), thus allowing us to place the first upper limit on the ratio R = Gamma (D+ → tau+nu)/Gamma( D+ → mu+nu). The ratio of R to the Standard Model expectation of 2.65 then is <1.8 at 90% C. L., consistent with the prediction of lepton universality. In the second analysis, we examine e+ e-- → D-sD*+s and D-*sD+s interactions at 4170 MeV using the CLEO-c detector in order to measure the decay constant fD+s . We use the D+s → ℓ+nu channel, where the ℓ+ designates either a mu+ or a tau+, when the tau+ → pi+nu. Analyzing both modes independently, we determine B ( D+s → mu+nu) = (0.594 +/- 0.066 +/- 0.031)%, B ( D+s → tau+nu) = (8.0 +/- 1.3 +/- 0.4)%. We also analyze them simultaneously to find an effective value of B ( D+s → mu+nu) = (0.621 +/- 0.058 +/- 0.032)% and extract fD+s = 270 +/- 13 +/- 7 MeV. Combining with our previous determination of B (D+ → mu+nu), we also find the ratio fD+s/fD+ = 1.21 +/- 0.11 +/- 0.04. We compare with current theoretical estimates. Finally, we limit B ( D+s → e+nu) < 1.3 x 10 --4 at 90% confidence level.

BEAMING NEUTRINOS AND ANTI-NEUTRINOS ACROSS THE EARTH TO DISENTANGLE NEUTRINO MIXING PARAMETERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fargion, Daniele; D'Armiento, Daniele; Paggi, Paolo

2012-10-10

A result from MINOS seemed to indicate that the mass splitting and mixing angle of anti-neutrinos is different from that of neutrinos, suggesting a charge-parity-time (CPT) violation in the lepton sector. However, more recent MINOS data reduced the {nu}{sub {mu}}-{nu}-bar{sub {mu}} differences leading to a narrow discrepancy nearly compatible with no CPT violation. However, the last few years of OPERA activity on the appearance of a tau lepton (one unique event) still has not been probed and more tools may be required to disentangle a list of parameters ({mu}-{tau} flavor mixing, tau appearance, any eventual CPT violation, {theta}{sub 13} anglemore » value, and any hierarchy neutrino mass). Atmospheric anisotropy in muon neutrino spectra in the DeepCore, at ten to tens of GeV (unpublished), can hardly reveal asymmetry in the eventual {nu}{sub {mu}}-{nu}-bar{sub {mu}} oscillation parameters. Here we considered how the longest baseline neutrino oscillation available, crossing most of Earth's diameter, may improve the measurement and at best disentangle any hypothetical CPT violation occurring between the earliest (2010) and the present (2012) MINOS bounds (with 6{sigma} a year), while testing {tau} and even the appearance of {tau}-bar at the highest rate. The {nu}{sub {mu}} and {nu}-bar{sub {mu}} disappearance correlated with the tau appearance is considered for those events at the largest distances. We thus propose a beam of {nu}{sub {mu}} and {nu}-bar{sub {mu}} crossing through the Earth, within an OPERA-like experiment from CERN (or Fermilab), in the direction of the IceCube-DeepCore {nu} detector at the South Pole. The ideal energy lies at 21 GeV to test the disappearance or (for any tiny CPT violation) the partial {nu}-bar{sub {mu}} appearance. Such a tuned detection experiment may lead to a strong signature of {tau} or {tau}-bar generation even within its neutral current noise background events: nearly one {tau}-bar or two {tau} a day. The tau appearance signal is above (or within) 10{sigma} a year, even for a 1% OPERA-like experiment. Peculiar configurations for {theta}{sub 13} and the hierarchy neutrino mass test may also be better addressed by a DeepCore-PINGU array detector beaming {nu}{sub {mu}} and observing {nu}{sub e} at 6 GeV neutrino energy windows.« less

Method and apparatus for improving resolution in spectrometers processing output steps from non-ideal signal sources

DOEpatents

Warburton, William K.; Momayezi, Michael

2006-06-20

A method and apparatus for processing step-like output signals (primary signals) generated by non-ideal, for example, nominally single-pole ("N-1P ") devices. An exemplary method includes creating a set of secondary signals by directing the primary signal along a plurality of signal paths to a signal summation point, summing the secondary signals reaching the signal summation point after propagating along the signal paths to provide a summed signal, performing a filtering or delaying operation in at least one of said signal paths so that the secondary signals reaching said summing point have a defined time correlation with respect to one another, applying a set of weighting coefficients to the secondary signals propagating along said signal paths, and performing a capturing operation after any filtering or delaying operations so as to provide a weighted signal sum value as a measure of the integrated area Q_gT of the input signal.

Double Beta Decays and Neutrinos - Experiments and MOON

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ejiri, H.; National Institute of Radiological Sciences, Chiba, 263-8555

2008-01-24

This is a brief review of the present and future experiments of neutrino-less double beta decays (0{nu}{beta}{beta}) and the MOON (Mo Observatory Of Neutrinos) project. High sensitivity 0{nu}{beta}{beta} experiments are unique and realistic probes for studying the Majorana nature of neutrinos and the absolute mass scale as suggested by neutrino oscillation experiments. MOON aims at spectroscopic 0{nu}{beta}{beta} studies with the {nu}-mass sensitivity of 100-30 meV by means of a super ensemble of multilayer modules of scintillator plates and tracking detector planes.

NuSTAR Seeks Hidden Black Holes

NASA Image and Video Library

2015-07-06

Top: An illustration of NASA's Nuclear Spectroscopic Telescope Array, or NuSTAR, in orbit. The unique school bus-long mast allows NuSTAR to focus high energy X-rays. Lower-left: A color image from NASA's Hubble Space Telescope of one of the nine galaxies targeted by NuSTAR in search of hidden black holes. Bottom-right: An artist's illustration of a supermassive black hole, actively feasting on its surroundings. The central black hole is hidden from direct view by a thick layer of encircling gas and dust. http://photojournal.jpl.nasa.gov/catalog/PIA19348

Results from the HARP Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Catanesi, M. G.

2008-02-21

Hadron production is a key ingredient in many aspects of {nu} physics. Precise prediction of atmospheric {nu} fluxes, characterization of accelerator {nu} beams, quantification of {pi} production and capture for {nu}-factory designs, all of these would profit from hadron production measurements. HARP at the CERN PS was the first hadron production experiment designed on purpose to match all these requirements. It combines a large, full phase space acceptance with low systematic errors and high statistics. HARP was operated in the range from 3 GeV to 15 GeV. We briefly describe here the most recent results.

Optical pumping of the. nu. /sub 3/ +. nu. /sub 4/ band of the CF/sub 4/ molecule

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piltch, M.S.; Hinsley, R.; Eckhardt, R.

1979-01-01

The possible development of a room-temperature, 16 ..mu..m CF/sub 4/ laser optically pumped by 5 ..mu..m radiation from a frequency-doubled CO/sub 2/ laser was investigated. This laser would utilize pumping of the ..nu../sub 3/ + ..nu../sub 4/ band of CF/sub 4/ at 1916 cm/sup -1/ with subsequent lasing to ..nu../sub 3/ levels at 1283 cm/sup -1/ where there is essentially no thermally excited population. A spectrophone instrument was used to measure absorption cross sections of CF/sub 4/ at the second harmonic frequencies of 22 of the 10 ..mu..m CO/sub 2/ laser transitions. Lasing experiments to detect transitions at 16 ..mu..mmore » are described.« less

Installing heterobimetallic cobalt–aluminum single sites on a metal organic framework support

DOE PAGES

Thompson, Anthony B.; Pahls, Dale R.; Bernales, Varinia; ...

2016-08-22

Here, a heterobimetallic cobalt-aluminum complex was immobilized onto the metal organic framework NU-1000 using a simple solution-based deposition procedure. Characterization data are consistent with a maximum loading of a single Co-Al complex per Zr 6 node of NU-1000. Furthermore, the data support that the Co-Al bimetallic complex is evenly distributed throughout the NU-1000 particle, binds covalently to the Zr6 nodes, and occupies the NU-1000 apertures with the shortest internode distances (~8.5 Å). Heating the anchored Co-Al complex on NU-1000 at 300 °C for 1 h in air completely removes the organic ligand of the complex without affecting the structural integritymore » of the MOF support. We propose that a Co-Al oxide cluster is formed in place of the anchored complex in NU-1000 during heating. Collectively, the results suggest that well-defined heterobimetallic complexes can be effective precursors for installing two different metals simultaneously onto a MOF support. The CoAl-functionalized NU-1000 samples catalyze the oxidation of benzyl alcohol to benzaldehyde with tert-butyl hydroperoxide as a stoichiometric oxidant. Density functional theory calculations were performed to elucidate the detailed structures of the Co-Al active sites on the Zr 6-nodes, and a Co-mediated catalytic mechanism is proposed.« less

Addendum to NuMI shielding assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vaziri, Kamran; /Fermilab

2007-10-01

The original safety assessment and the Safety Envelope for the NuMI beam line corresponds to 400 kW of beam power. The Main Injector is currently capable of and approved for producing 500 kW of beam power2. However, operation of the NuMI beam line at 400 kW of power brings up the possibility of an occasional excursion above 400 kW due to better than usual tuning in one of the machines upstream of the NuMI beam line. An excursion above the DOE approved Safety Envelope will constitute a safety violation. The purpose of this addendum is to evaluate the radiological issuesmore » and modifications required to operate the NuMI beam line at 500 kW. This upgrade will allow 400 kW operations with a reasonable safety margin. Configuration of the NuMI beam line, boundaries, safety system and the methodologies used for the calculations are as described in the original NuMI SAD. While most of the calculations presented in the original shielding assessment were based on Monte Carlo simulations, which were based on the design geometries, most of the results presented in this addendum are based on the measurements conducted by the AD ES&H radiation safety group.« less

NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures

PubMed Central

Seldin, Lindsey; Muroyama, Andrew; Lechler, Terry

2016-01-01

Mitotic spindle orientation is used to generate cell fate diversity and drive proper tissue morphogenesis. A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types. Previous research proposed that cortical dynein/dynactin was sufficient to generate forces on astral microtubules (MTs) to orient the spindle, with NuMA acting as a passive tether. In this study, we demonstrate that dynein/dynactin is insufficient for spindle orientation establishment in keratinocytes and that NuMA’s MT-binding domain, which targets MT tips, is also required. Loss of NuMA-MT interactions in skin caused defects in spindle orientation and epidermal differentiation, leading to neonatal lethality. In addition, we show that NuMA-MT interactions are also required in adult mice for hair follicle morphogenesis and spindle orientation within the transit-amplifying cells of the matrix. Loss of spindle orientation in matrix cells results in defective differentiation of matrix-derived lineages. Our results reveal an additional and direct function of NuMA during mitotic spindle positioning, as well as a reiterative use of spindle orientation in the skin to build diverse structures. DOI: http://dx.doi.org/10.7554/eLife.12504.001 PMID:26765568

Environmental Assessment and Inversion Studies Based on Features of the Acoustic Vector Field in Shallow Water

DTIC Science & Technology

2008-09-30

A tte nu at io n 1 20 40 60 80 100 1.7 1.75 1.8 1.85 1.9 D en si ty 1 20 40 60 80 100 1520 1540 1560 1580 1600 S ou nd S pe ed 1 20 40 60 80 100 0...0.01 0.02 0.03 0.04 0.05 0.06 0.07 LAYER A tte nu at io n 1 20 40 60 80 100 1.3 1.35 1.4 1.45 1.5 1.55 1.6 D en si ty 1 20 40 60 80 100 1460...Hermand, ed.), no. YS-1, La Spezia, Italy: SACLANT Undersea Research Centre, Dec. 1996. 2. J.-P. Hermand, ``Broad-band geoacoustic inversion in

Theoretical study of hydrogen bonding interaction in nitroxyl (HNO) dimer: interrelationship of the two N-H...O blue-shifting hydrogen bonds.

PubMed

Liu, Ying; Liu, Wenqing; Li, Haiyang; Liu, Jianguo; Yang, Yong

2006-10-19

The hydrogen bonding interactions of the HNO dimer have been investigated using ab initio molecular orbital and density functional theory (DFT) with the 6-311++G(2d,2p) basis set. The natural bond orbital (NBO) analysis and atom in molecules (AIM) theory were applied to understand the nature of the interactions. The interrelationship between one N-H...O hydrogen bond and the other N-H...O hydrogen bond has been established by performing partial optimizations. The dimer is stabilized by the N-H...O hydrogen bonding interactions, which lead to the contractions of N-H bonds as well as the characteristic blue-shifts of the stretching vibrational frequencies nu(N-H). The NBO analysis shows that both rehybridization and electron density redistribution contribute to the large blue-shifts of the N-H stretching frequencies. A quantitative correlations of the intermolecular distance H...O (r(H...O)) with the parameters: rho at bond critical points (BCPs), s-characters of N atoms in N-H bonds, electron densities in the sigma*(N-H), the blue-shift degrees of nu(N-H) are presented. The relationship between the difference of rho (|Deltarho|) for the one hydrogen bond compared with the other one and the difference of interaction energy (DeltaE) are also illustrated. It indicates that for r(H...O) ranging from 2.05 to 2.3528 A, with increasing r(H...O), there is the descending tendency for one rho(H...O) and the ascending tendency for the other rho(H...O). r(H...O) ranging from 2.3528 to 2.85 A, there are descending tendencies for the two rho(H...O) with increasing r(H...O). On the potential energy surface of the dimer, the smaller the difference between one rho(H...O) and the other rho(H...O) is, the more stable the structure is. As r(H...O) increases, the blue-shift degrees of nu(N-H) decrease. The cooperative descending tendencies in s-characters of two N atoms with increasing r(H...O) contribute to the decreases in blue-shift degrees of nu(N-H). Ranging from 2.05 to 2.55 A, the increase of the electron density in one sigma*(N-H) with elongating r(H...O) weakens the blue-shift degrees of nu(N-H), simultaneously, the decrease of the electron density in the other sigma*(N-H) with elongating r(H...O) strengthens the blue-shift degrees of nu(N-H). Ranging from 2.55 to 2.85 A, the cooperative ascending tendencies of the electron densities in two sigma*(N-H) with increasing r(H...O) contribute to the decreases in blue-shift degrees of nu(N-H).

Nuclear Masses in the A=80 Region of Nuclei

NASA Astrophysics Data System (ADS)

Cuka, N.; Gadala-Maria, A.; Aprahamian, A.

1996-05-01

Nucleosynthesis in explosive hydrogen burning at high temperatures above 8x10^8 K is characterized by the rp-process. A recent study^1 of the reaction flow and their associated time scales showed that the reaction path may in fact proceed well beyond the A=80 region of nuclei. An accurate simulation of the nucleosynthesis and energy generation of this process strongly depends on reliable nuclear physics input parameters such as masses, lifetimes, and reaction rates. We have extended the use of the simple P-parametrization^2,3 that had been applied to the characterization of the structure contributions to the nuclear masses in the actinides to include the A=80 region. The results will be presented along with predictions of masses for presently unknown masses of nuclei along the rp-process path. ^1 R. Wallace and S. Woosley, Ap. J. Suppl. 45, 389 (81). ^2 R. F. Casten, D.S. Brenner and P.E. Haustein, Phys. Rev. Lett. 58, 658 (87). ^3 P. Haustein, D.S. Brenner and R.F. Casten, Phys. Rev. C 38, 467 (88).

THE INFLUENCE OF FRESHWATER RUNOFF ON BIOMASS, MORPHOMETRICS, AND PRODUCTION OF THALASSIA TESTUDINUM. (R827453)

EPA Science Inventory

Efforts to restore more natural freshwater flows in South Florida will impact Biscayne Bay. In order to evaluate possible effects of decreased freshwater discharge on the seagrass Thalassia testudinum, we determined the biomass, density, morphometrics (width, length, nu...

Autoantibodies in SLE but not in scleroderma react with protein-stripped nucleosomes.

PubMed

Suer, Waltraud; Dähnrich, Cornelia; Schlumberger, Wolfgang; Stöcker, Winfried

2004-06-01

Autoantibodies against nucleosomes (ANuA) are known to be sensitive markers for systemic lupus erythematosus (SLE), but their clinical relevance seemed to be limited because sera from patients with progressive systemic sclerosis (PSS) also showed positive reactions with conventional ANuA ELISA test systems (anti-Nu1 ELISA). It was generally assumed thatANuA were associated with both diseases. Using discontinuous sucrose gradient centrifugation to generate pure nucleosomes, we discovered by chance that at the 30-50% sucrose interface an antigen (Nu2) banded which was demonstrably free of non-histone components and histone H1. The two different nucleosome preparations, Nu1 and Nu2, were used in parallel as antigenic substrates in standardised ELISA tests to analyse sera from SLE (295 patients), PSS (119) and patients with other rheumatic diseases (101). With Nu1, 62% of the SLE and 52% of the PSS sera showed positive reactions. Two sera from patients suffering from Sjögren's syndrome (SS) and one from polymyositis were also positive. Using the Nu2 preparation, 58% of the SLE but none of the PSS sera showed a positive reaction. One serum from a patient with SS was also positive. It could be shown that it was the PSS-specific autoantigen Scl-70 in the nucleosome preparation (Nu1) which contributed to the positive reactions of the PSS sera in conventional ANuA test systems, whereas in the Nu2 preparation no remaining Scl-70 was detectable. The present study definitely proved that ANuA are highly and specifically associated with SLE but not with PSS.

Rayleigh-Bénard turbulence modified by two-way coupled inertial, nonisothermal particles

NASA Astrophysics Data System (ADS)

Park, Hyungwon John; O'Keefe, Kevin; Richter, David H.

2018-03-01

Direct numerical simulation (DNS) combined with the Lagrangian point particle model is used to study Rayleigh-Bénard convection in order to understand modifications due to the interaction of inertial, nonisothermal particles with buoyancy-driven turbulence. In this system, turbulence can be altered through direct momentum coupling, as well as through buoyancy modification via thermal coupling between phases. We quantify the effect of the dispersed phase by changes to the total integrated turbulent kinetic energy (TKE) and Nusselt number (Nu). The dispersed particles experience gravitational settling and are introduced at the lower wall so that turbulence must overcome the settling velocity for the particles to vertically distribute throughout the domain. We focus primarily on particle inertia, settling velocity, mass fraction, and the ratio of the particle to fluid specific heat. Furthermore, individual contributions by the momentum coupling and thermal coupling are studied to see which most significantly changes Nu and TKE. Our results show that particles with Stokes number of order unity maximize Nu, corresponding to a peak of clustering and attenuation of TKE. Increased mass fractions lead to a linear increase of Nu and decrease of TKE. With varying specific heat ratio, Nu and TKE exhibit monotonic behaviors, where in the high limit particles become isothermal and depend upon the initialized particle temperature. It is also shown that particles two-way coupled only through momentum attenuate Nu and weaken TKE, while thermal-only coupling also weakens TKE but enhances Nu. When both couplings are present, however, thermal coupling overwhelms the momentum coupling attenuation, and the net result is an enhancement of Nu.

NuMex-02- A High oleic Valencia peanut with partial resistance to Sclerotinia blight

USDA-ARS?s Scientific Manuscript database

NuMex-02 is a high oleic Valencia peanut (Arachis hypogaea L., subsp. fastigiata var. fastigiata) cultivar developed by the New Mexico Agricultural Experiment Station, Clovis, New Mexico. NuMex-02 originated from a cross made between NM Valencia A and OLin. Pedigree selection was practiced based on...

A comparison of the nutritional quality of organic and conventional ready-to-eat breakfast cereals based on NuVal scores.

PubMed

Woodbury, Nancy J; George, Valerie A

2014-07-01

To identify whether there were differences in nutritional quality between organic and conventional ready-to-eat breakfast cereals of similar types, based on NuVal scores. The current descriptive study analysed NuVal scores for 829 ready-to-eat breakfast cereals and eighteen different cereal types. ANOVA was used to compare the mean NuVal scores of 723 conventional cereals with those of 106 organic cereals. Ready-to-eat breakfast cereals (n 829) with NuVal scores. Not applicable. There was no significant difference in NuVal scores between conventional (mean 28·4 (sd 13·4)) and organic (mean 30·6 (sd 13·2)) cereal types. Consumers who choose the organic version of a ready-to-eat breakfast cereal believing that nutritional quality is superior may not be making a valid assumption. Public health nutrition educators must help consumers understand that organic cereals are not necessarily more nutritious and their consumption could result in excessive intake of undesirable nutrients, such as fat, sugar and sodium.

Picosecond coherent anti-Stokes Raman scattering (CARS) study of vibrational dephasing of carbon disulfide and benzene in solution

NASA Technical Reports Server (NTRS)

Perry, Joseph W.; Woodward, Anne M.; Stephenson, John C.

1986-01-01

The vibrational dephasing of the 656/cm mode (nu1, a1g) of CS2 and the 991/cm mode (nu2, a1g) of benzene have been studied as a function of concentration in mixtures with a number of solvents using a ps time-resolved CARS technique. This technique employs two tunable synchronously-pumped mode-locked dye lasers in a stimulated Raman pump, coherent anti-Stokes Raman probe time-resolved experiment. Results are obtained for CS2 in carbon tetrachloride, benzene, nitrobenzene, and ethanol and for benzene nu2 in CS2. The dephasing rates of CS2 nu1 increase on dilution with the polar solvents and decrease or remain constant on dilution with the nonpolar solvents. The CS2/benzene solutions show a contrasting behavior, with the CS2 nu1 dephasing rate being nearly independent of concentration whereas the benzene nu2 dephasing rate decreases on dilution. These results are compared to theoretical models for vibrational dephasing of polyatomic molecules in solution.

Distribution of the microelastic properties within the human anterior mitral leaflet.

PubMed

Jensen, Anne Skakkebaek; Baandrup, Ulrik; Hasenkam, J Michael; Kundu, Tribikram; Jørgensen, Claus Schiøtt

2006-12-01

Knowledge of the biomechanical properties of the mitral valve leaflets and their relation to histologic structure is of importance for understanding the leaflet movement characteristics under normal and pathologic conditions, but such knowledge is not yet available. The aim of this study was to determine biomechanical properties of the human anterior mitral leaflet on a microscopic scale. We used scanning acoustic microscopy (SAM) to examine the human anterior mitral leaflet. Sections of fixed human anterior mitral leaflet tissue were obtained from postmortem human anterior mitral leaflets (n = 5). We measured the speed of sound (nu(L)) in each histologic layer in three regions-of-interest (ROIs): these were at the annular edge, at the valve midpoint and close to the free edge. nu(L) varied in the three histologic layers (p < 0.01). It was higher in the fibrous layer (1.76 km/s) compared with the atrial layer (1.75 km/s) and ventricular layer (1.73 km/s). Also, nu(L) differed between positions along the length of the annulus-free edge line (p < 0.01), showing a decline from the annular edge (1.76 km/s) to the free edge (1.73 km/s), both as a whole and also within the atrial and the fibrous layer. These results demonstrate that the fibrous layer is stiffer than the atrial and ventricular layer and that the leaflet as a whole and within the atrial and the fibrous layer is stiffer at the annulus part in comparison with those near the free edge. (E-mail: ).

THE RELATIONSHIP BETWEEN {nu}{sub max} AND AGE t FROM ZAMS TO RGB-TIP FOR LOW-MASS STARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang, Y. K.; Gai, N., E-mail: tyk450@163.com, E-mail: ning.gai@hotmail.com

2013-07-10

Stellar age is an important quantity in astrophysics, which is useful for many fields both in the universe and galaxies. It cannot be determined by direct measurements, but can only be estimated or inferred. We attempt to find a useful indicator of stellar age, which is accurate from the zero-age main sequence to the tip of red giant branch for low-mass stars. Using the Yale Rotation and Evolution Code (YREC), a grid of stellar models has been constructed. Meanwhile, the frequency of maximum oscillations' power {nu}{sub max} and the large frequency separation {Delta}{nu} are calculated using the scaling relations. Formore » the stars, the masses of which are from 0.8 M{sub Sun} to 2.8 M{sub Sun }, we can obtain the {nu}{sub max} and stellar age by combing the scaling relations with the four sets of grid models (YREC, Dotter et al., Marigo et al., and YY isochrones). We find that {nu}{sub max} is tightly correlated and decreases monotonically with the age of the star from the main sequence to the red giant evolutionary stages. Moreover, we find that the line shapes of the curves in the Age versus {nu}{sub max} diagram, which is plotted by the four sets of grid models, are consistent for red giants with masses from 1.1 M{sub Sun} to 2.8 M{sub Sun }. For red giants, the differences of correlation coefficients between Age and {nu}{sub max} for different grid models are minor and can be ignored. Interestingly, we find two peaks that correspond to the subgiants and bump of red giants in the Age versus {nu}{sub max} diagram. By general linear least-squares, we make the polynomial fitting and deduce the relationship between log(Age) and log({nu}{sub max}) in red giants' evolutionary state.« less

The connection from the Sun to Planets and the Galaxy by QFT

NASA Astrophysics Data System (ADS)

Chen, Shao-Guang

I deduce the new gravitational formula from the variance in mass of QFT and GR (H05-0029-08, E15-0039 -08, E14-0032-08, D31-0054-10) in the partial differential: f (QFT) = f (GR) = delta∂ (m v)/delta∂ t = f _{P} + f _{C} , f _{P} = m delta∂ v / delta∂ t = - ( G m M /r (2) ) r / r, f _{C} = v delta∂ m / delta∂ t = - ( G mM / r (2) ) v / c (1), f (QFT) is the quasi-Casimir pressure of net virtual neutrinos nuν _{0} flux (after counteract contrary direction nuν _{0}). f (GR) is equivalent to Einstein’s equation as a new version of GR. GR can be inferred from Eq.(1) thereby from QFT, but QFT cannot be inferred from Eq.(1) or GR. f (QFT) is essential but f (GR) is phenomenological. Eq.(1) is obtained just by to absorb the essence of corpuscule collided gravitation origin ism proposed by Fatio in 1690 and 1920 Majorana’s experiment concept about gravitational shield effect again fuse with QFT. Its core content is that the gravity produced by particles collide cannot linear addition, i.e., Eq.(1) with the adding nonlinearity caused by the variable mass to replace the nonlinearity of Einstein’s equation and the nonlinear gravitation problems can be solved using the classical gradual approximation of alone f _{P} and alone f _{C}. Such as the calculation of advance of the perihelion of QFT, let the gravitational potential U = - G M /r which is just the distribution density of net nuν _{0} flux. From SR we again get Eq.(1): f (QFT) = f _{P} + f _{C}, f _{P} = - m ( delta∂ U / delta∂ r) r / r, f _{C} = - m ( delta∂U / delta∂ r) v / c , U = (1 - betaβ (2) )V, V is the Newtonian gravitational potential. f_{ P} correspond the change rate of three-dimensional momentum p, f_{C} correspond the change rate of fourth dimensional momentum i m c which show directly as a dissipative force of mass change. In my paper ‘To cross the great gap between the modern physics and classic physics, China Science &Technology Overview 129 85-91(2011)’ with the measuring value of one-way velocity of light (H05-0020-08) to replace the infinity value of light speed measured by Galileo in 1607, thereby the mass m in NM will become variable m. Or else, the energy of electron in accelerator should not larger than 0.51Mev which conflict with the experimental fact. According to the variable mass and the definition of force we again get Eq.(1) from NM without hypothesis, i.e., NM is generalized in which Galileo coordinates transformation and the action at a distance will be of no effect. Eq.(1) has more reliable experimental base and generalized NM may be applied to the high-speed and the microscopic conditions. Because of the result of a test of GR with use of a hydrogen-maser frequency standard in a spacecraft launched nearly vertically upward to 10000 km (R. F. C. Vessot et.al., Phys. Rev. Lett. 45, 2081 (1980)), the isotropy of one-way velocity of light had been validated at the 1*10 (-10) level (D2.4-0030-12, H0.1-0009-12, H0.2-0008-12). Again from the Lorentz transformation (H01-0006-08) and the uncertainty principle (H05-0036-10) deduced from the metrical results of Doppler effects, SR and QM, thereby QFT and GR, all become the inferential theorems from generalized NM. Eq.(1) is as a bridge to join the modern physics and classical physics. In my paper ‘Basal electric and magnetic fields of celestial bodies come from positive-negative charge separation caused by gravitation of quasi-Casimir pressure in weak interaction’ (D31-0054-10): According to QFT the gravitation is the statistic average pressure collided by net virtual neutrinos nuν _{0} flux, the net nuν _{0} flux can press a part freedom electrons in plasma of ionosphere into the surface of celestial bodies, the static electric force of redundant positive ions prevents electrons further falling and till reach the equilibrium of stable spatial charge distribution, which is just the cause of the geomagnetic field and the geo-electric field. In the solar surface plasma add the negative charge from ionosphere electrons again rotate, thereby come into being the solar basal magnetic field. The solar surface plasma with additional electrons get the dynamic balance between the upwards force of stable positive charge distribution in the solar upside gas and the downwards force of the vacuum net nuν _{0} flux pressure (solar gravity). When the Jupiter enter into the connecting line of Sun and the center of Galaxy, the pressure (solar gravity) observed from earth will weaken because of the Jupiter stop (shield) the most net nuν _{0} flux which shoot to Sun from the center of Galaxy. The dynamic balance of forces on the solar surface plasma at once is broken and the plasma will upwards eject as the solar wind with redundant negative charge, at the same time, the solar surface remain a cavity as a sunspot whorl with the positive charge relative to around plasma. The whorl caused by that the reaction of plasma eject front and upwards with the different velocity at different latitude of solar rotation, leads to the cavity around in the downwards and backwards helix movement. The solar rotation more slow, when the cavity is filled by around plasma in the reverse turn direction and return to small negative charge, the Jupiter at front had been produced a new cavity. Thereby we had observe the sunspot pair with different directions whorl and different magnetic polarity. Jupiter possess half mass of all planets in solar system, its action to stop net nuν _{0} flux is primary, then Jupiter’s period of 11.8 sidereal years accord basically with the period of sunspot eruptions. From the Sun to the Jupiter again to the Galaxy to be connected by the vacuum net virtual neutrinos nuν _{0} flux of QFT, its distribution density is just the gravitational potential U = - G M /r of QFT. Foregoing analysis is only an example, using the net nuν _{0} flux and U we research and dispose the connection from the Sun to Planets and the Galaxy should obtain many testable results by observation.

Riboflavin Depletion Promotes Tumorigenesis in HEK293T and NIH3T3 Cells by Sustaining Cell Proliferation and Regulating Cell Cycle-Related Gene Transcription.

PubMed

Long, Lin; He, Jian-Zhong; Chen, Ye; Xu, Xiu-E; Liao, Lian-Di; Xie, Yang-Min; Li, En-Min; Xu, Li-Yan

2018-05-07

Riboflavin is an essential component of the human diet and its derivative cofactors play an established role in oxidative metabolism. Riboflavin deficiency has been linked with various human diseases. The objective of this study was to identify whether riboflavin depletion promotes tumorigenesis. HEK293T and NIH3T3 cells were cultured in riboflavin-deficient or riboflavin-sufficient medium and passaged every 48 h. Cells were collected every 5 generations and plate colony formation assays were performed to observe cell proliferation. Subcutaneous tumorigenicity assays in NU/NU mice were used to observe tumorigenicity of riboflavin-depleted HEK293T cells. Mechanistically, gene expression profiling and gene ontology analysis were used to identify abnormally expressed genes induced by riboflavin depletion. Western blot analyses, cell cycle analyses, and chromatin immunoprecipitation were used to validate the expression of cell cycle-related genes. Plate colony formation of NIH3T3 and HEK293T cell lines was enhanced >2-fold when cultured in riboflavin-deficient medium for 10-20 generations. Moreover, we observed enhanced subcutaneous tumorigenicity in NU/NU mice following injection of riboflavin-depleted compared with normal HEK293T cells (55.6% compared with 0.0% tumor formation, respectively). Gene expression profiling and gene ontology analysis revealed that riboflavin depletion induced the expression of cell cycle-related genes. Validation experiments also found that riboflavin depletion decreased p21 and p27 protein levels by ∼20%, and increased cell cycle-related and expression-elevated protein in tumor (CREPT) protein expression >2-fold, resulting in cyclin D1 and CDK4 levels being increased ∼1.5-fold, and cell cycle acceleration. We also observed that riboflavin depletion decreased intracellular riboflavin levels by 20% and upregulated expression of riboflavin transporter genes, particularly SLC52A3, and that the changes in CREPT and SLC52A3 correlated with specific epigenetic changes in their promoters in riboflavin-depleted HEK293T cells. Riboflavin depletion contributes to HEK293T and NIH3T3 cell tumorigenesis and may be a risk factor for tumor development.

Neutrino-nucleus neutral current elastic interactions measurement in MiniBooNE

NASA Astrophysics Data System (ADS)

Perevalov, Denis

The MiniBooNE experiment at the Fermi National Accelerator Laboratory (Fermilab) was designed to search for numu → nu e neutrino oscillations at Deltam 2 ˜ 1 eV2 using an intense neutrino flux with an average energy Enu ˜ 700 MeV. From 2002 to 2009 MiniBooNE has accumulated more than 1.0x1021 protons on target (POT) in both neutrino and antineutrino modes. MiniBooNE provides a perfect platform for detailed measurements of exclusive and semi-inclusive neutrino cross-sections, for which MiniBooNE has the largest samples of events up to date, such as neutral current elastic (NCE), neutral current pi 0, charged current quasi-elastic (CCQE), charged current pi +, and other channels. These measured cross-sections, in turn, allow to improve the knowledge of nucleon structure. This thesis is devoted to the study of NCE interactions. Neutrino-nucleus neutral current elastic scattering (nuN → nu N) accounts for about 18% of all neutrino interactions in MiniBooNE. Using a high-statistics, high purity sample of NCE interactions in MiniBooNE, the flux-averaged NCE differential cross-section has been measured and is being reported here. Further study of the NCE cross-section allowed for probing the structure of nuclei. The main interest in the NCE cross-section is that it may be sensitive to the strange quark contribution to the nucleon spin, Deltas, this however requires a separation of NCE proton (nup → nu p) from NCE neutron (nun → nun ) events, which in general is a challenging task. MiniBooNE uses a Cherenkov detector, which imposes restrictions on the measured nucleon kinematic variables, mainly due to the impossibility to reconstruct the nucleon direction below the Cherenkov threshold. However, at kinetic energies above this threshold MiniBooNE is able to identify NCE proton events that do not experience final state interactions (FSI). These events were used for the Deltas measurement. In this thesis MiniBooNE reports the NCE (n+p) cross-section, the measurement of the axial mass, MA, and the Delta s parameter from the NCE data.

Infrared fluorescence efficiencies for the nu1 and nu5 bands of formaldehyde in the solar radiation field

NASA Technical Reports Server (NTRS)

Reuter, D. C.; Mumma, M. J.; Nadler, S.

1989-01-01

Formaldehyde scattering strengths have been determined for equilibrium distributions of 100 K, 50 K, 20 K, and for the the non-LTE case of an essentially fully relaxed distribution. Integrated band g factors of 2.89 x 10 to the -4th photons/s per molecule for nu1 and 3.83 x 10 to the -4th for nu 5 are obtained. The results indicate that the most promising regions to search for cometary H2CO are at about 2782/cm, at 2794.5/cm, and at about 2835/cm.

Spectroscopic Studies of Double Beta Decays and MOON

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ejiri, H.; Nuclear Science, Czech Technical University, Brehova, Prague, Czech Republic, National Institute of Radiological Sciences, Chiba, 263-8555

2007-10-12

This is a brief review of future spectroscopic experiments of neutrino-less double beta decays (0{nu}{beta}{beta}) and the MOON (Mo Observatory Of Neutrinos) project. Spectroscopic 0{nu}{beta}{beta} experiments of MOON, SuperNEMO and DCBA are planned to study Majorana masses in the quasi-degenerate (QD) and inverted mass hierarchy (IH) regions. MOON aims at 0{nu}{beta}{beta} studies with the {nu}-mass sensitivities of 100-30 meV by means of a super ensemble of multi-layer modules, each being consist of a scintillator plate, two tracking detector planes and a thin {beta}{beta} source film.

Determining neutrino mass from the cosmic microwave background alone.

PubMed

Kaplinghat, Manoj; Knox, Lloyd; Song, Yong-Seon

2003-12-12

Distortions of cosmic microwave background temperature and polarization maps caused by gravitational lensing, observable with high angular resolution and high sensitivity, can be used to measure the neutrino mass. Assuming two massless species and one with mass m(nu), we forecast sigma(m(nu))=0.15 eV from the Planck satellite and sigma(m(nu))=0.04 eV from observations with twice the angular resolution and approximately 20 times the sensitivity. A detection is likely at this higher sensitivity since the observation of atmospheric neutrino oscillations requires Deltam(2)(nu) greater, similar (0.04 eV)(2).

Mouse oocytes nucleoli rescue embryonic development of porcine enucleolated oocytes.

PubMed

Morovic, Martin; Strejcek, Frantisek; Nakagawa, Shoma; Deshmukh, Rahul S; Murin, Matej; Benc, Michal; Fulka, Helena; Kyogoku, Hirohisa; Pendovski, Lazo; Fulka, Josef; Laurincik, Jozef

2017-12-01

It is well known that nucleoli of fully grown mammalian oocytes are indispensable for embryonic development. Therefore, the embryos originated from previously enucleolated (ENL) oocytes undergo only one or two cleavages and then their development ceases. In our study the interspecies (mouse/pig) nucleolus transferred embryos (NuTE) were produced and their embryonic development was analyzed by autoradiography, transmission electron microscopy (TEM) and immunofluorescence (C23 and upstream binding factor (UBF)). Our results show that the re-injection of isolated oocyte nucleoli, either from the pig (P + P) or mouse (P + M), into previously enucleolated and subsequently matured porcine oocytes rescues their development after parthenogenetic activation and some of these develop up to the blastocyst stage (P + P, 11.8%; P + M, 13.5%). In nucleolus re-injected 8-cell and blastocyst stage embryos the number of nucleoli labeled with C23 in P + P and P + M groups was lower than in control (non-manipulated) group. UBF was localized in small foci within the nucleoli of blastocysts in control and P + P embryos, however, in P + M embryos the labeling was evenly distributed in the nucleoplasm. The TEM and autoradiographic evaluations showed the formation of functional nucleoli and de novo rRNA synthesis at the 8-cell stage in both, control and P + P group. In the P + M group the formation of comparable nucleoli was delayed. In conclusion, our results indicate that the mouse nucleolus can rescue embryonic development of enucleolated porcine oocytes, but the localization of selected nucleolar proteins, the timing of transcription activation and the formation of the functional nucleoli in NuTE compared with control group show evident aberrations.

KSC-2012-1174

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, workers rewrap NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) in a protective shroud. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1164

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, workers lift NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) from its shipping container. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

Electronic and vibrational spectroscopy and vibrationally mediated photodissociation of V+(OCO).

PubMed

Citir, Murat; Altinay, Gokhan; Metz, Ricardo B

2006-04-20

Electronic spectra of gas-phase V+(OCO) are measured in the near-infrared from 6050 to 7420 cm(-1) and in the visible from 15,500 to 16,560 cm(-1), using photofragment spectroscopy. The near-IR band is complex, with a 107 cm(-1) progression in the metal-ligand stretch. The visible band shows clearly resolved vibrational progressions in the metal-ligand stretch and rock, and in the OCO bend, as observed by Brucat and co-workers. A vibrational hot band gives the metal-ligand stretch frequency in the ground electronic state nu3'' = 210 cm(-1). The OCO antisymmetric stretch frequency in the ground electronic state (nu1'') is measured by using vibrationally mediated photodissociation. An IR laser vibrationally excites ions to nu1'' = 1. Vibrationally excited ions selectively dissociate following absorption of a second, visible photon at the nu1' = 1 <-- nu1'' = 1 transition. Rotational structure in the resulting vibrational action spectrum confirms that V+(OCO) is linear and gives nu1'' = 2392.0 cm(-1). The OCO antisymmetric stretch frequency in the excited electronic state is nu1' = 2368 cm(-1). Both show a blue shift from the value in free CO2, due to interaction with the metal. Larger blue shifts observed for complexes with fewer ligands agree with trends seen for larger V+(OCO)n clusters.

Addressing the characterisation challenge to understand catalysis in MOFs: the case of nanoscale Cu supported in NU-1000.

PubMed

Platero-Prats, Ana E; Li, Zhanyong; Gallington, Leighanne C; Peters, Aaron W; Hupp, Joseph T; Farha, Omar K; Chapman, Karena W

2017-09-01

We explore the dynamic structure and reactivity of Cu species supported on NU-1000. By combining pair distribution function (PDF) analysis and difference envelope density (DED) analysis of in situ synchrotron-based X-ray scattering data, we simultaneously probe the local structure of supported Cu-species, their distribution within NU-1000 and distortions of the NU-1000 lattice under conditions relevant to catalysis and catalyst activation. These analyses show that atomic layer deposition (ALD) of Cu in NU-1000 (Cu-AIM) leads to the formation of Cu-oxo clusters within the small pores that connect the triangular and hexagonal channels. Exposure of Cu-AIM to a reducing atmosphere at 200 °C produces metallic Cu 0 of two distinct particle sizes: ∼4 nm nanoparticles and small sub-nanometer clusters. The size of these nanoparticles appears to be constrained by NU-1000 pore dimensions, with evidence of the sub-nanometer clusters being bound within the triangular channels flanked by pyrene rings. This supported Cu 0 -NU-1000 system is catalytically active for gas-phase ethylene hydrogenation. Exposure of the catalyst to oxidative atmosphere re-oxidises the Cu species to a Cu 2 O cuprite phase. The dynamic restructuring of the system in different chemical environments underscores the importance of probing these systems in situ.

Addressing the characterisation challenge to understand catalysis in MOFs: the case of nanoscale Cu supported in NU-1000

DOE PAGES

Platero-Prats, Ana E.; Li, Zhanyong; Gallington, Leighanne C.; ...

2017-04-03

Here, we explore the dynamic structure and reactivity of Cu species supported on NU-1000. By combining pair distribution function (PDF) analysis and difference envelope density (DED) analysis ofin situsynchrotron-based X-ray scattering data, we simultaneously probe the local structure of supported Cu-species, their distribution within NU-1000 and distortions of the NU-1000 lattice under conditions relevant to catalysis and catalyst activation. Our analyses show that atomic layer deposition (ALD) of Cu in NU-1000 (Cu-AIM) leads to the formation of Cu-oxo clusters within the small pores that connect the triangular and hexagonal channels. Exposure of Cu-AIM to a reducing atmosphere at 200 °Cmore » produces metallic Cu 0of two distinct particle sizes: ~4 nm nanoparticles and small sub-nanometer clusters. The size of these nanoparticles appears to be constrained by NU-1000 pore dimensions, with evidence of the sub-nanometer clusters being bound within the triangular channels flanked by pyrene rings. This supported Cu 0–NU-1000 system is catalytically active for gas-phase ethylene hydrogenation. Exposure of the catalyst to oxidative atmosphere re-oxidises the Cu species to a Cu 2O cuprite phase. The dynamic restructuring of the system in different chemical environments underscores the importance of probing these systemsin situ.« less

Upgrade of the Minos+ Experiment Data Acquisition for the High Energy NuMI Beam Run

DOE PAGES

Badgett, William; Hahn, Steve R.; Torretta, Donatella; ...

2016-03-14

The Minos+ experiment is an extension of the Minos experiment at a higher energy and more intense neutrino beam, with the data collection having begun in the fall of 2013. The neutrino beam is provided by the Neutrinos from the Main Injector (NuMI) beam-line at Fermi National Accelerator Laboratory (Fermilab). The detector apparatus consists of two main detectors, one underground at Fermilab and the other in Soudan, Minnesota with the purpose of studying neutrino oscillations at a base line of 735 km. The original data acquisition system has been running for several years collecting data from NuMI, but with themore » extended run from 2013, parts of the system needed to be replaced due to obsolescence, reliability problems, and data throughput limitations. Specifically, we have replaced the front-end readout controllers, event builder, and data acquisition computing and trigger processing farms with modern, modular and reliable devices with few single points of failure. The new system is based on gigabit Ethernet TCP/IP communication to implement the event building and concatenation of data from many front-end VME readout crates. The simplicity and partitionability of the new system greatly eases the debugging and diagnosing process. As a result, the new system improves throughput by about a factor of three compared to the old system, up to 800 megabits per second, and has proven robust and reliable in the current run.« less

A theory of the n-i-p silicon solar cell

NASA Technical Reports Server (NTRS)

Goradia, C.; Weinberg, I.; Baraona, C.

1981-01-01

A computer model has been developed, based on an analytical theory of the high base resistivity BSF n(+)(pi)p(+) or p(+)(nu)n(+) silicon solar cell. The model makes very few assumptions and accounts for nonuniform optical generation, generation and recombination in the junction space charge region, and bandgap narrowing in the heavily doped regions. The paper presents calculated results based on this model and compares them to available experimental data. Also discussed is radiation damage in high base resistivity n(+)(pi)p(+) space solar cells.

Measurement of the angular distribution of the electron from W {r_arrow} e = {nu} decay, in p pbar at {radical}s = 1.8 TeV, as function of P{sub T}{sup W}

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-06-01

The goal of this work is to study the behavior of the angular distribution of the electron from the decay of the W boson in a specific rest frame of the W, the Collins-Soper frame. More specifically, the parameter {alpha}{sub 2} from the expression d{sigma}/d(P{sub T}{sup W}){sup 2} d cos {theta}* = k(1 + {alpha}{sub 2} cos {theta}* + {alpha}{sup 2}(cos {theta}*){sup 2}), corresponding to the distribution of cos {theta}* in the Collins-Soper frame, was measured. The experimental value of {alpha}P{sub 2} was compared with the predictions made by E. Mirkes [11] who included the radiative QCD perturbations in themore » weak-interaction B{sub boson} {r_arrow} lepton + lepton. This experimental value was extracted for the first time using knowledge about how the radiative QCD perturbations will modify the predictions given by the Electro-Weak process only.« less

NuSTAR Observations of X-Ray Flares from Young Stellar Objects

NASA Astrophysics Data System (ADS)

Vievering, Juliana; Glesener, Lindsay; Grefenstette, Brian; Smith, David

2018-01-01

Young stellar objects (YSOs), which tend to flare more frequently and at higher temperatures than what is typically observed on Sun-like stars, are excellent targets for studying the physical processes behind large flaring events. In the hard x-ray regime, radiation can penetrate through dense circumstellar material, and it is possible to measure thermal emission from hot plasma and to search for nonthermal emission from accelerated particles, which are key components for understanding the nature of energy release in these flares. Additionally, high-energy x-ray emission can ionize material in the disk, which may have implications for planet formation. To investigate hard x-ray emission from YSOs, three 50ks observations of a star-forming region called rho Ophiuchi have been taken with the Nuclear Spectroscopic Telescope Array (NuSTAR). Through use of direct focusing optics, NuSTAR provides unprecedented sensitivity in the hard x-ray regime, making these YSO observations the first of their kind. Multiple stellar flares have been identified in the data set; here we present the current spectral and timing analyses of the brightest of the these events, exploring the way energy is released as well as the effects of these large flares on the surrounding environment.

State-based verification of RTCP-nets with nuXmv

NASA Astrophysics Data System (ADS)

Biernacka, Agnieszka; Biernacki, Jerzy; Szpyrka, Marcin

2015-12-01

The paper deals with an algorithm of translation of RTCP-nets' (real-time coloured Petri nets) coverability graphs into nuXmv state machines. The approach enables users to verify RTCP-nets with model checking techniques provided by the nuXmv tool. Full details of the algorithm are presented and an illustrative example of the approach usefulness is provided.

The Debreather and NuTech: A Reply to Kleespies

ERIC Educational Resources Information Center

Ogden, Russel D.

2010-01-01

This article responds to Phillip Kleespies's (2010/this issue) commentary on NuTech fieldworkers and their use of the debreather. Non-medical assistance with suicide raises legitimate concerns about accountability, public safety, and care for those who are suffering. Given that suicide is not a crime, an outcome of the NuTech movement may be that…

Regular physical exercise improves cardiac autonomic and muscle vasodilatory responses to isometric exercise in healthy elderly.

PubMed

Sarmento, Adriana de Oliveira; Santos, Amilton da Cruz; Trombetta, Ivani Credidio; Dantas, Marciano Moacir; Oliveira Marques, Ana Cristina; do Nascimento, Leone Severino; Barbosa, Bruno Teixeira; Dos Santos, Marcelo Rodrigues; Andrade, Maria do Amparo; Jaguaribe-Lima, Anna Myrna; Brasileiro-Santos, Maria do Socorro

2017-01-01

The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults. Twenty healthy participants, 10 sedentary and 10 physically active older adults, were evaluated and paired by gender, age, and body mass index. Sympathetic and parasympathetic cardiac activity (spectral and symbolic heart rate analysis) and muscle blood flow (venous occlusion plethysmography) were measured for 10 minutes at rest (baseline) and during 3 minutes of isometric handgrip exercise at 30% of the maximum voluntary contraction (sympathetic excitatory maneuver). Variables were analyzed at baseline and during 3 minutes of isometric exercise. Cardiac autonomic parameters were analyzed by Wilcoxon and Mann-Whitney tests. Muscle vasodilatory response was analyzed by repeated-measures analysis of variance followed by Tukey's post hoc test. Sedentary older adults had higher cardiac sympathetic activity compared to physically active older adult subjects at baseline (63.13±3.31 vs 50.45±3.55 nu, P =0.02). The variance (heart rate variability index) was increased in active older adults (1,438.64±448.90 vs 1,402.92±385.14 ms, P =0.02), and cardiac sympathetic activity (symbolic analysis) was increased in sedentary older adults (5,660.91±1,626.72 vs 4,381.35±1,852.87, P =0.03) during isometric handgrip exercise. Sedentary older adults showed higher cardiac sympathetic activity (spectral analysis) (71.29±4.40 vs 58.30±3.50 nu, P =0.03) and lower parasympathetic modulation (28.79±4.37 vs 41.77±3.47 nu, P =0.03) compared to physically active older adult subjects during isometric handgrip exercise. Regarding muscle vasodilation response, there was an increase in the skeletal muscle blood flow in the second (4.1±0.5 vs 3.7±0.4 mL/min per 100 mL, P =0.01) and third minute (4.4±0.4 vs 3.9±0.3 mL/min per 100 mL, P =0.03) of handgrip exercise in active older adults. The results indicate that regular physical activity improves neurovascular control of muscle blood flow and cardiac autonomic response during isometric handgrip exercise in healthy older adult subjects.

Regular physical exercise improves cardiac autonomic and muscle vasodilatory responses to isometric exercise in healthy elderly

PubMed Central

Sarmento, Adriana de Oliveira; Santos, Amilton da Cruz; Trombetta, Ivani Credidio; Dantas, Marciano Moacir; Oliveira Marques, Ana Cristina; do Nascimento, Leone Severino; Barbosa, Bruno Teixeira; Dos Santos, Marcelo Rodrigues; Andrade, Maria do Amparo; Jaguaribe-Lima, Anna Myrna; Brasileiro-Santos, Maria do Socorro

2017-01-01

The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults. Twenty healthy participants, 10 sedentary and 10 physically active older adults, were evaluated and paired by gender, age, and body mass index. Sympathetic and parasympathetic cardiac activity (spectral and symbolic heart rate analysis) and muscle blood flow (venous occlusion plethysmography) were measured for 10 minutes at rest (baseline) and during 3 minutes of isometric handgrip exercise at 30% of the maximum voluntary contraction (sympathetic excitatory maneuver). Variables were analyzed at baseline and during 3 minutes of isometric exercise. Cardiac autonomic parameters were analyzed by Wilcoxon and Mann–Whitney tests. Muscle vasodilatory response was analyzed by repeated-measures analysis of variance followed by Tukey’s post hoc test. Sedentary older adults had higher cardiac sympathetic activity compared to physically active older adult subjects at baseline (63.13±3.31 vs 50.45±3.55 nu, P=0.02). The variance (heart rate variability index) was increased in active older adults (1,438.64±448.90 vs 1,402.92±385.14 ms, P=0.02), and cardiac sympathetic activity (symbolic analysis) was increased in sedentary older adults (5,660.91±1,626.72 vs 4,381.35±1,852.87, P=0.03) during isometric handgrip exercise. Sedentary older adults showed higher cardiac sympathetic activity (spectral analysis) (71.29±4.40 vs 58.30±3.50 nu, P=0.03) and lower parasympathetic modulation (28.79±4.37 vs 41.77±3.47 nu, P=0.03) compared to physically active older adult subjects during isometric handgrip exercise. Regarding muscle vasodilation response, there was an increase in the skeletal muscle blood flow in the second (4.1±0.5 vs 3.7±0.4 mL/min per 100 mL, P=0.01) and third minute (4.4±0.4 vs 3.9±0.3 mL/min per 100 mL, P=0.03) of handgrip exercise in active older adults. The results indicate that regular physical activity improves neurovascular control of muscle blood flow and cardiac autonomic response during isometric handgrip exercise in healthy older adult subjects. PMID:28721030

MINORITY STRESS, POSITIVE IDENTITY DEVELOPMENT, AND DEPRESSIVE SYMPTOMS: IMPLICATIONS FOR RESILIENCE AMONG SEXUAL MINORITY MALE YOUTH

PubMed Central

Bruce, Douglas; Harper, Gary W.; Bauermeister, Jose A.

2015-01-01

Introduction Minority stress processes have been shown to have significant associations with negative mental health outcomes among sexual minority populations. Given that adversity may be experienced growing up as a sexual minority in heteronormative, if not heterosexist, environments, our research on resilience among sexual minority male youth proposes that positive identity development may buffer the effects of a range of minority stress processes. Methods An ethnically diverse sample of 200 sexual minority males ages 16–24 (mean age, 20.9 years) was recruited using mixed recruitment methods. We developed and tested two new measures: concealment stress during adolescence and sexual minority-related positive identity development. We then tested a path model that assessed the effects of minority stressors, positive identity development, and social support on major depressive symptoms. Results Experience of stigma was associated with internalized homophobia (β=.138, p<.05) and major depressive symptoms (β=1.076, OR=2.933, p<.001), and internalized homophobia partially mediated experience’s effects on major depression (β=.773, OR=2.167, p<.001). Concealment stress was associated with positive identity development (β=.155, p<.05) and internalized homophobia (β=.418, p<.001), and positive identity development partially mediated concealment stress’s effects on internalized homophobia (β=−.527, p<.001). Concealment stress demonstrated a direct effect on major depression (β=1.400, OR=4.056, p<.001), and indirect paths to social support through positive identity development. Conclusions With these results, we offer an exploratory model that empirically identifies significant paths among minority stress dimensions, positive identity development, and major depressive symptoms. This study helps further our understanding of minority stress, identity development, and resources of resilience among sexual minority male youth. PMID:26478901

MINORITY STRESS, POSITIVE IDENTITY DEVELOPMENT, AND DEPRESSIVE SYMPTOMS: IMPLICATIONS FOR RESILIENCE AMONG SEXUAL MINORITY MALE YOUTH.

PubMed

Bruce, Douglas; Harper, Gary W; Bauermeister, Jose A

2015-09-01

Minority stress processes have been shown to have significant associations with negative mental health outcomes among sexual minority populations. Given that adversity may be experienced growing up as a sexual minority in heteronormative, if not heterosexist, environments, our research on resilience among sexual minority male youth proposes that positive identity development may buffer the effects of a range of minority stress processes. An ethnically diverse sample of 200 sexual minority males ages 16-24 (mean age, 20.9 years) was recruited using mixed recruitment methods. We developed and tested two new measures: concealment stress during adolescence and sexual minority-related positive identity development. We then tested a path model that assessed the effects of minority stressors, positive identity development, and social support on major depressive symptoms. Experience of stigma was associated with internalized homophobia (β=.138, p<.05) and major depressive symptoms (β=1.076, OR=2.933, p<.001), and internalized homophobia partially mediated experience's effects on major depression (β=.773, OR=2.167, p<.001). Concealment stress was associated with positive identity development (β=.155, p<.05) and internalized homophobia (β=.418, p<.001), and positive identity development partially mediated concealment stress's effects on internalized homophobia (β=-.527, p<.001). Concealment stress demonstrated a direct effect on major depression (β=1.400, OR=4.056, p<.001), and indirect paths to social support through positive identity development. With these results, we offer an exploratory model that empirically identifies significant paths among minority stress dimensions, positive identity development, and major depressive symptoms. This study helps further our understanding of minority stress, identity development, and resources of resilience among sexual minority male youth.

Oceanographic upwelling conditions influence signaling pathways involved in muscle growth of intertidal fish.

PubMed

Zuloaga, Rodrigo; Almarza, Oscar; Valdés, Juan A; Molina, Alfredo; Pulgar, José

2018-04-01

Few studies have addressed the impact of the upwelling oceanographical conditions on biological processes, such as growth, using a molecular and physiological approach. Upwelling conditions are characterized by low temperature seawater and high nutrient availability, which represents an ideal opportunity to understand how habitat modulates animal performance at different levels of biological complexity. We aimed to assess intraspecific variations in weight, oxygen consumption, protein content, and key signaling pathways involved in muscle-growth (protein kinase B (AKT) and extracellular signal-regulated kinase (ERK)) under experimental trials considering high/low seawater temperatures with full/restricted food rations. For this purpose, we studied Girella laevifrons, one of the most abundant fish species inhabiting rocky intertidal zones along the Eastern South Pacific coasts. Using fish obtained from upwelling (U) and non-upwelling (NU) zones, we reported that U animals displayed higher growth performance during both contrasting trials, with a weight gain (~3 g), lower oxygen consumption (~12%), and higher protein contents (~20%). Only ERK showed significant differences during the trials (~2-fold downregulation between NU and U fish). We also found that U fish increased protein ubiquitination in high water temperature and restricted food ration in contrast to NU fish. Our results help to elucidate how upwelling conditions may influence fish growth at physiological and molecular levels. Still, future analyses are necessary to improve the information regarding the impact of U and NU condition on animals, as well as the possible applications of this data in the aquaculture industry. Copyright © 2018 Elsevier Inc. All rights reserved.

Path-Dependent Travel Time Prediction Variance and Covariance for a Global Tomographic P- and S-Velocity Model

NASA Astrophysics Data System (ADS)

Hipp, J. R.; Ballard, S.; Begnaud, M. L.; Encarnacao, A. V.; Young, C. J.; Phillips, W. S.

2015-12-01

Recently our combined SNL-LANL research team has succeeded in developing a global, seamless 3D tomographic P- and S-velocity model (SALSA3D) that provides superior first P and first S travel time predictions at both regional and teleseismic distances. However, given the variable data quality and uneven data sampling associated with this type of model, it is essential that there be a means to calculate high-quality estimates of the path-dependent variance and covariance associated with the predicted travel times of ray paths through the model. In this paper, we describe a methodology for accomplishing this by exploiting the full model covariance matrix and show examples of path-dependent travel time prediction uncertainty computed from our latest tomographic model. Typical global 3D SALSA3D models have on the order of 1/2 million nodes, so the challenge in calculating the covariance matrix is formidable: 0.9 TB storage for 1/2 of a symmetric matrix, necessitating an Out-Of-Core (OOC) blocked matrix solution technique. With our approach the tomography matrix (G which includes a prior model covariance constraint) is multiplied by its transpose (GTG) and written in a blocked sub-matrix fashion. We employ a distributed parallel solution paradigm that solves for (GTG)-1 by assigning blocks to individual processing nodes for matrix decomposition update and scaling operations. We first find the Cholesky decomposition of GTG which is subsequently inverted. Next, we employ OOC matrix multiplication methods to calculate the model covariance matrix from (GTG)-1 and an assumed data covariance matrix. Given the model covariance matrix, we solve for the travel-time covariance associated with arbitrary ray-paths by summing the model covariance along both ray paths. Setting the paths equal and taking the square root yields the travel prediction uncertainty for the single path.

KSC-2012-1140

NASA Image and Video Library

2012-01-27

VANDENBERG AIR FORCE BASE, Calif. -- Workers position the environmentally controlled shipping container enclosing NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) in the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California. The spacecraft arrived at 7:52 a.m. PST after a cross-country trip from Orbital Sciences' manufacturing plant in Dulles, Va., which began Jan. 24. The spacecraft will be offloaded into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After NuSTAR is removed from its shipping container, checkout and other processing activity will begin. The spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. After processing is completed, the rocket and spacecraft will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1139

NASA Image and Video Library

2012-01-27

VANDENBERG AIR FORCE BASE, Calif. -- Workers roll the environmentally controlled shipping container enclosing NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) through the door of the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California. The spacecraft arrived at 7:52 a.m. PST after a cross-country trip from Orbital Sciences' manufacturing plant in Dulles, Va., which began Jan. 24. The spacecraft will be offloaded into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After NuSTAR is removed from its shipping container, checkout and other processing activity will begin. The spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. After processing is completed, the rocket and spacecraft will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1132

NASA Image and Video Library

2012-01-27

VANDENBERG AIR FORCE BASE, Calif. -- NASA's Nuclear Spectroscopic Telescope Array (NuSTAR), enclosed in an environmentally controlled shipping container, is delivered by tractor-trailer to processing facility 1555 at Vandenberg Air Force Base (VAFB) in California. The spacecraft arrived at 7:52 a.m. PST after a cross-country trip from Orbital Sciences' manufacturing plant in Dulles, Va., which began Jan. 24. The spacecraft will be offloaded into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After NuSTAR is removed from its shipping container, checkout and other processing activity will begin. The spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. After processing is completed, the rocket and spacecraft will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1134

NASA Image and Video Library

2012-01-27

VANDENBERG AIR FORCE BASE, Calif. -- NASA's Nuclear Spectroscopic Telescope Array (NuSTAR), enclosed in an environmentally controlled shipping container, approaches processing facility 1555 at Vandenberg Air Force Base (VAFB) in California. The spacecraft arrived at 7:52 a.m. PST after a cross-country trip from Orbital Sciences' manufacturing plant in Dulles, Va., which began Jan. 24. The spacecraft will be offloaded into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After NuSTAR is removed from its shipping container, checkout and other processing activity will begin. The spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. After processing is completed, the rocket and spacecraft will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1135

NASA Image and Video Library

2012-01-27

VANDENBERG AIR FORCE BASE, Calif. -- NASA's Nuclear Spectroscopic Telescope Array (NuSTAR), enclosed in an environmentally controlled shipping container, arrives at processing facility 1555 at Vandenberg Air Force Base (VAFB) in California. The spacecraft arrived at 7:52 a.m. PST after a cross-country trip from Orbital Sciences' manufacturing plant in Dulles, Va., which began Jan. 24. The spacecraft will be offloaded into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After NuSTAR is removed from its shipping container, checkout and other processing activity will begin. The spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. After processing is completed, the rocket and spacecraft will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

NuSTAR Hard X-Ray Survey of the Galactic Center Region. II. X-Ray Point Sources

NASA Technical Reports Server (NTRS)

Hong, Jaesub; Mori, Kaya; Hailey, Charles J.; Nynka, Melania; Zhang, Shou; Gotthelf, Eric; Fornasini, Francesca M.; Krivonos, Roman; Bauer, Franz; Perez, Kerstin;

An unbiased view of X-ray obscuration amongst active galactic nuclei with NuLANDS

NASA Astrophysics Data System (ADS)

Boorman, Peter Gregory; Gandhi, Poshak; Stern, Daniel; Harrison, Fiona; NuSTAR Obscured AGN Team

2018-01-01

Nearly all active galactic nuclei (AGN) are obscured in X-rays behind column densities of NH ≥ 1022 cm-2. Hard X-ray studies have proven very effective to quanitfy the levels of obscuration amongst AGN, up to and just above the Compton-thick limit (NH ˜ 1.5 × 1024 cm-2). However, Compton-thick sources with NH values beyond this limit are typically missed in hard X-ray all-sky surveys such as Swift/BAT, requiring many studies to apply considerable bias corrections to account for the loss. Incorrectly quanitfying the heavily obscured AGN population can have a dramatic effect on synthesis models designed to fit the Cosmic X-ray Background spectrum, due to their significant contribution to the peak flux of the background at ~30 keV. This is what motivated the NuSTAR Local AGN NH Distribution Survey (NuLANDS) - a NuSTAR 1 Ms legacy survey of an obscuration-independent, infrared selected sample of AGN, undetected by BAT and unobserved by NuSTAR before - a considerable number of which are predicted to be heavily obscured. NuSTAR is the first true X-ray focusing instrument capable of spectral analysis > 10 keV, and as such can and will place robust constraints on the NH values of these elusive AGN. In this poster, I will present the first results from NuLANDS, including multiple newly identified Compton-thick AGN, previously undetected in the Swift/BAT 70-month catalog. I will further highlight the exciting prospects for the complete NuLANDS sample, with the ultimate goal of constructing a representative NH distribution of AGN in the local Universe, requiring minimal bias corrections.

Measurement of B(D+-->K(*0)l(+)nu(l)).

PubMed

Brandenburg, G; Ershov, A; Kim, D Y-J; Wilson, R; Benslama, K; Eisenstein, B I; Ernst, J; Gollin, G D; Hans, R M; Karliner, I; Lowrey, N; Marsh, M A; Plager, C; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Edwards, K W; Ammar, R; Besson, D; Zhao, X; Anderson, S; Frolov, V V; Kubota, Y; Lee, S J; Li, S Z; Poling, R; Smith, A; Stepaniak, C J; Urheim, J; Ahmed, S; Alam, M S; Jian, L; Saleem, M; Wappler, F; Eckhart, E; Gan, K K; Gwon, C; Hart, T; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pedlar, T K; Thayer, J B; Von Toerne, E; Wilksen, T; Zoeller, M M; Richichi, S J; Severini, H; Skubic, P; Dytman, S A; Nam, S; Savinov, V; Chen, S; Hinson, J W; Lee, J; Miller, D H; Pavlunin, V; Shibata, E I; Shipsey, I P J; Cronin-Hennessy, D; Lyon, A L; Park, C S; Park, W; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Maravin, Y; Narsky, I; Stroynowski, R; Ye, J; Artuso, M; Boulahouache, C; Bukin, K; Dambasuren, E; Mountain, R; Skwarnicki, T; Stone, S; Wang, J C; Mahmood, A H; Csorna, S E; Danko, I; Xu, Z; Bonvicini, G; Cinabro, D; Dubrovin, M; McGee, S; Bornheim, A; Lipeles, E; Pappas, S P; Shapiro, A; Sun, W M; Weinstein, A J; Masek, G; Paar, H P; Mahapatra, R; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G; Vogel, H; Adam, N E; Alexander, J P; Bebek, C; Berkelman, K; Blanc, F; Boisvert, V; Cassel, D G; Drell, P S; Duboscq, J E; Ecklund, K M; Ehrlich, R; Gibbons, L; Gittelman, B; Gray, S W; Hartill, D L; Heltsley, B K; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Magerkurth, A; Mahlke-Krüger, H; Meyer, T O; Mistry, N B; Nordberg, E; Palmer, M; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Thayer, J G; Urner, D; Valant-Spaight, B; Viehhauser, G; Warburton, A; Weinberger, M; Athar, S B; Avery, P; Stoeck, H; Yelton, J

2002-11-25

Using 13.53 fb(-1) of CLEO data, we have measured the ratios of the branching fractions R(+)(e),R(+)(mu) and the combined branching fraction ratio R(+)(l), defined by R(+)(l)=[B(D+-->K(*0)l(+)nu(l))]/[B(D+-->K-pi(+)pi(+))]. We find R(+)(e)=0.74+/-0.04+/-0.05, R(+)(mu)=0.72+/-0.10+/-0.05, and R(+)(l)=0.74+/-0.04+/-0.05, where the first and second errors are statistical and systematic, respectively. The known branching fraction B(D+-->K-pi(+)pi(+)) leads to B(D+-->K(*0)e(+)nu(e))=(6.7+/-0.4+/-0.5+/-0.4)%, B(D+-->K(*0)mu(+)nu(mu))=(6.5+/-0.9+/-0.5+/-0.4)%, and B(D+-->K(*0)l(+)nu(l))=(6.7+/-0.4+/-0.5+/-0.4)%, where the third error is due to the uncertainty in B(D+-->K-pi(+)pi(+)).

Infrared laser absorption spectroscopy of the nu4 (sigma u) fundamental and associated nu11(pi u) hot band of C7 - Evidence for alternating rigidity in linear carbon clusters

NASA Technical Reports Server (NTRS)

Heath, J. R.; Saykally, R. J.

1991-01-01

The first characterization of the bending potential of the C7 cluster is reported via the observation of the v = 1(1) and v = 2 deg levels of the nu11 (pi u) bend as hot bands associated with the nu4 (sigma u) antisymmetric stretch fundamental. The lower state hot band rotational constants are measured to be 1004.4(1.3) and 1123.6(9.0) MHz, constituting a 9.3 and 22 percent increase over the ground state rotational constant, 918.89 (41) MHz. These large increases are strong quartic and sextic centrifugal distortion constants determined for the ground and nu 4 = 1 states are found to be anomalously large and negative, evidencing strong perturbations between stretching and bending modes.

The First Focused Hard X-Ray Images of the Sun with NuSTAR

NASA Technical Reports Server (NTRS)

Grefenstette, Brian W.; Glesener, Lindsay; Kruckner, Sam; Hudson, Hugh; Hannah, Iain G.; Smith, David M.; Vogel, Julia K.; White, Stephen M.; Madsen, Kristin K.; Marsh, Andrew J.;

‘GREENER’ SURFACTANTS FROM BIO-BASED WASTE AS EFFICIENT ALTERNATIVES TO NONYLPHENOL ETHOXYLATES

EPA Science Inventory

All bio-based surfactants synthesized over the course of the project will be tested for their ability to lower the surface tension at the air-water interface using a Du Nüoy ring tensiometer. The cleaning efficiency of the surfactants will be tested at the Toxics Use Reduc...

In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice.

PubMed

Tsutsui, Ayumi; Ogura, Akihiro; Tahara, Tsuyoshi; Nozaki, Satoshi; Urano, Sayaka; Hara, Mitsuko; Kojima, Soichi; Kurbangalieva, Almira; Onoe, Hirotaka; Watanabe, Yasuyoshi; Taniguchi, Naoyuki; Tanaka, Katsunori

2016-06-15

Advanced glycation end products (AGEs) are associated with various diseases, especially during aging and the development of diabetes and uremia. To better understand these biological processes, investigation of the in vivo kinetics of AGEs, i.e., analysis of trafficking and clearance properties, was carried out by molecular imaging. Following the preparation of Cy7.5-labeled AGE-albumin and intravenous injection in BALB/cA-nu/nu mice, noninvasive fluorescence kinetics analysis was performed. In vivo imaging and fluorescence microscopy analysis revealed that non-enzymatic AGEs were smoothly captured by scavenger cells in the liver, i.e., Kupffer and other sinusoidal cells, but were unable to be properly cleared from the body. Overall, these results highlight an important link between AGEs and various disorders associated with them, which may serve as a platform for future research to better understand the processes and mechanisms of these disorders.

[Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism].

PubMed

Rybus-Kalinowska, Barbara; Zwirska-Korczala, Krystyna; Kalinowski, Mariusz; Kukla, Michał; Birkner, Ewa; Jochem, Jerzy

2009-01-01

The recent investigations point out the significant role of oxidative stress in the development of thyroid gland disease. The present study was designed to investigate the variation of oxidative stae in women with non-autoimmunological subclinical hyperthyroidism. The study was conducted on 20 females with non-autoimmunological subclinical hyperthyroidism and 15 healthy women. Manganase-containing superoxide dismutase (Mn-SOD) and extracellular superoxide dismutase (EC-SOD) plasma activity, and malondialdehyde (MDA) plasma concentration were measured. EC-SOD plasma activity was significantly higher in women with subclinical hyperthyroidism when compared with the control group (13.3 +/- 2.1 vs. 10.9 +/- 1.4 NU/ml; p < 0.05), unlike Mn-SOD (4.2 +/- 0.5 vs. 4.0 +/- 1.0 NU/ml). MDA plasma concentration increased significantly in women with subclinical hyperthyroidism (3.5 +/- 1.2 vs. 2.0 +/- 0.6 micromol/l; p < 0.05). The increased EC-SOD plasma activity may reflect disturbances of oxidative state in subclinical hyperthyroidism. Parallel increase of MDA plasma concentration may indicate enhancement of lipid peroxidationin in patients with subclinical hyperthyroidism.

Absolute branching fraction measurements for D+ and D0 inclusive semileptonic decays.

PubMed

Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; Athar, S B; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Wiss, J; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Severini, H; Dytman, S A; Love, W; Savinov, V; Aquines, O; Li, Z; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Brock, I; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L

2006-12-22

We present measurements of the inclusive branching fractions for the decays D+-->Xe+ nu(e) and D0-->Xe+ nu(e), using 281 pb(-1) of data collected on the psi(3770) resonance with the CLEO-c detector. We find B(D0-->Xe+ nu(e)) = (6.46+/-0.17+/-0.13)% and B(D+-->Xe+ nu(e)) = (16.13+/-0.20+/-0.33)%. Using the known D meson lifetimes, we obtain the ratio Gamma(D+)sl/Gamma(D0)sl = 0.985+/-0.028+/-0.015, confirming isospin invariance at the level of 3%. The positron momentum spectra from D+ and D0 have consistent shapes.

Measurement of νμ and νe Events in an Off-Axis Horn-Focused Neutrino Beam

NASA Astrophysics Data System (ADS)

Adamson, P.; Aguilar-Arevalo, A. A.; Anderson, C. E.; Bazarko, A. O.; Bishai, M.; Brice, S. J.; Brown, B. C.; Bugel, L.; Cao, J.; Choudhary, B. C.; Coney, L.; Conrad, J. M.; Cox, D. C.; Curioni, A.; Djurcic, Z.; Finley, D. A.; Fleming, B. T.; Ford, R.; Gallagher, H. R.; Garcia, F. G.; Garvey, G. T.; Green, C.; Green, J. A.; Harris, D.; Hart, T. L.; Hawker, E.; Hylen, J.; Imlay, R.; Johnson, R. A.; Karagiorgi, G.; Kasper, P.; Katori, T.; Kobilarcik, T.; Kopp, S.; Kourbanis, I.; Koutsoliotas, S.; Laird, E. M.; Linden, S. K.; Link, J. M.; Liu, Y.; Liu, Y.; Loiacono, L.; Louis, W. C.; Marchionni, A.; Mahn, K. B. M.; Marsh, W.; McGregor, G.; Messier, M. D.; Metcalf, W.; Meyers, P. D.; Mills, F.; Mills, G. B.; Monroe, J.; Moore, C. D.; Nelson, J. K.; Nelson, R. H.; Nguyen, V. T.; Nienaber, P.; Nowak, J. A.; Ouedraogo, S.; Patterson, R. B.; Pavlovic, Z.; Perevalov, D.; Polly, C. C.; Prebys, E.; Raaf, J. L.; Ray, H.; Roe, B. P.; Russell, A. D.; Sandberg, V.; Schirato, R.; Schmitz, D.; Shaevitz, M. H.; Shoemaker, F. C.; Smart, W.; Smith, D.; Sodeberg, M.; Sorel, M.; Spentzouris, P.; Stancu, I.; Stefanski, R. J.; Sung, M.; Tanaka, H. A.; Tayloe, R.; Tzanov, M.; Vahle, P.; van de Water, R.; Viren, B.; Wascko, M. O.; White, D. H.; Wilking, M. J.; Yang, H. J.; Yumiceva, F. X.; Zeller, G. P.; Zimmerman, E. D.; Zwaska, R.

2009-05-01

We report the first observation of off-axis neutrino interactions in the MiniBooNE detector from the NuMI beam line at Fermilab. The MiniBooNE detector is located 745 m from the NuMI production target, at 110 mrad angle (6.3°) with respect to the NuMI beam axis. Samples of charged-current quasielastic νμ and νe interactions are analyzed and found to be in agreement with expectation. This provides a direct verification of the expected pion and kaon contributions to the neutrino flux and validates the modeling of the NuMI off-axis beam.

Intensity of the /R/Q sub zero branch in the nu-9 fundamental of ethane. [laboratory spectra for Jupiter and Saturn IR observations

NASA Technical Reports Server (NTRS)

Tokunaga, A.; Varanasi, P.

1976-01-01

Recent observations of Jupiter and Saturn at 12 microns have shown strong emission in the nu-9 fundamental of ethane. In order to derive the abundance of ethane from the planetary observations, the absolute intensity of the (R)Q sub zero branch of the nu-9 fundamental was measured, yielding a value of 0.74 plus or minus 0.09/sq cm/atm at 300 K. In order to study the absorption features of the nu-9 fundamental, the computed rotational structure of the band was compared with the laboratory spectrum.

Large extra dimensions, sterile neutrinos and solar neutrino data.

PubMed

Caldwell, D O; Mohapatra, R N; Yellin, S J

2001-07-23

Solar, atmospheric, and LSND neutrino oscillation results require a light sterile neutrino, nu(B), which can exist in the bulk of extra dimensions. Solar nu(e), confined to the brane, can oscillate in the vacuum to the zero mode of nu(B) and via successive Mikheyev-Smirnov-Wolfenstein transitions to Kaluza-Klein states of nu(B). This new way to fit solar data is provided by both low and intermediate string scale models. From average rates seen in the three types of solar experiments, the Super-Kamiokande spectrum is predicted with 73% probability, but dips characteristic of the 0.06 mm extra dimension should be seen in the SNO spectrum.

Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program

PubMed Central

Hamey, Fiona K.; Errami, Youssef

2017-01-01

Differentiation of lineage-committed cells from multipotent progenitors requires the establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters, which is mediated by pioneer transcription factors that recruit activating chromatin remodeling complexes. Here we show that the Mbd3/nucleosome remodeling and deacetylation (NuRD) chromatin remodeling complex opposes this transcriptional pioneering during B cell programming of multipotent lymphoid progenitors by restricting chromatin accessibility at B cell enhancers and promoters. Mbd3/NuRD-deficient lymphoid progenitors therefore prematurely activate a B cell transcriptional program and are biased toward overproduction of pro–B cells at the expense of T cell progenitors. The striking reduction in early thymic T cell progenitors results in compensatory hyperproliferation of immature thymocytes and development of T cell lymphoma. Our results reveal that Mbd3/NuRD can regulate multilineage differentiation by constraining the activation of dormant lineage-specific enhancers and promoters. In this way, Mbd3/NuRD protects the multipotency of lymphoid progenitors, preventing B cell–programming transcription factors from prematurely enacting lineage commitment. Mbd3/NuRD therefore controls the fate of lymphoid progenitors, ensuring appropriate production of lineage-committed progeny and suppressing tumor formation. PMID:28899870

Study of \\Bpilnu and \\Brholnu decays and determination of \\Vub at \\babar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wulsin, H.Wells

2011-02-07

The authors report a measurement of the branching fractions for B{sup 0} {yields} {pi}{sup -}{ell}{sup +}{nu} and B{sup 0} {yields} {rho}{sup -}{ell}{sup +}{nu} decays using charged and neutral B decays with isospin constraints. They find {beta}(B{sup 0} {yields} {pi}{sup -}{ell}{sup +}{nu}) = (1.41 {+-} 0.05 {+-} 0.07) x 10{sup -4}, and {beta}(B{sup 0} {yields} {rho}{sup -}{ell}{sup +}{nu}) = (1.75 {+-} 0.15 {+-} 0.27) x 10{sup -4}, where the first error is statistical and the second is systematic. They measure {Delta}{beta}/{Delta}q{sup 2}, with 6 q{sup 2} bins for B{sup 0} {yields} {pi}{sup -}{ell}{sup +}{nu} and 3 q{sup 2} bins for B{supmore » 0} {yields} {rho}{sup -}{ell}{sup +}{nu}, and compare the distributions in data with theoretical predictions for the form factors. They use these branching fractions and form-factor calculations to determine |V{sub ub}|. Based on a combined fit to the FNAL/MILC lattice QCD calculation and data over the full q{sup 2} range, they find |V{sub ub}| = (2.95 {+-} 0.31) x 10{sup -3}.« less

Rayleigh-Benard turbulence modified by two-way coupled particles

NASA Astrophysics Data System (ADS)

Park, Hyungwon; O'Keefe, Kevin; Richter, David

2017-11-01

Direct numerical simulation (DNS) with Lagrangian point particles is used to study Rayleigh-Bénard convection to understand modifications due to the interaction of inertial particle, gauged by the turbulent kinetic energy (TKE) and Nusselt number (Nu). The initially dispersed particles experience gravitational settling, and become introduced at the lower wall such that turbulence must overcome the settling velocity for the particles to vertically distribute throughout the domain. The particle properties of interest are inertia, as characterized by the Stokes number, and settling velocity. Furthermore, individual contributions by the momentum-coupling and thermal-coupling are studied to see which most significantly changes Nu and TKE. Our results show that particles with Stokes number of order unity maximize Nu, corresponding to a peak of clustering and attenuation of TKE. It is also shown that particles two-way coupled only through momentum attenuate Nu and weaken TKE, while thermal-only coupling also weakens TKE but enhances Nu. When both couplings are present, however, thermal coupling overwhelms the attenuation caused by momentum coupling and the net result is an enhancement of Nu. NSF - Grant No. AGS-1429921, ONR - Grant No. N00014-16-1-2472, and Notre Dame Center for Research Computing.

Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD.

PubMed

Reddy, B Ashok; Bajpe, Prashanth Kumar; Bassett, Andrew; Moshkin, Yuri M; Kozhevnikova, Elena; Bezstarosti, Karel; Demmers, Jeroen A A; Travers, Andrew A; Verrijzer, C Peter

2010-11-01

ATP-dependent chromatin-remodeling complexes (remodelers) are essential regulators of chromatin structure and gene transcription. How remodelers can act in a gene-selective manner has remained enigmatic. A yeast two-hybrid screen for proteins binding the Drosophila transcription factor Tramtrack69 (TTK69) identified MEP1. Proteomic characterization revealed that MEP1 is a tightly associated subunit of the NuRD remodeler, harboring the Mi2 enzymatic core ATPase. In addition, we identified the fly homolog of human Deleted in oral cancer 1 (DOC1), also known as CDK2-associated protein 1 (CDK2AP1), as a bona fide NuRD subunit. Biochemical and genetic assays supported the functional association between MEP1, Mi2, and TTK69. Genomewide expression analysis established that TTK69, MEP1, and Mi2 cooperate closely to control transcription. The TTK69 transcriptome profile correlates poorly with remodelers other than NuRD, emphasizing the selectivity of remodeler action. On the genes examined, TTK69 is able to bind chromatin in the absence of NuRD, but targeting of NuRD is dependent on TTK69. Thus, there appears to be a hierarchical relationship in which transcription factor binding precedes remodeler recruitment.

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

PubMed Central

Zhang, Yi; Ng, Huck-Hui; Erdjument-Bromage, Hediye; Tempst, Paul; Bird, Adrian; Reinberg, Danny

1999-01-01

ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation represent mechanisms to alter nucleosome structure. NuRD is a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. The histone deacetylases HDAC1 and HDAC2 and the histone binding proteins RbAp48 and RbAp46 form a core complex shared between NuRD and Sin3-histone deacetylase complexes. The histone deacetylase activity of the core complex is severely compromised. A novel polypeptide highly related to the metastasis-associated protein 1, MTA2, and the methyl-CpG-binding domain-containing protein, MBD3, were found to be subunits of the NuRD complex. MTA2 modulates the enzymatic activity of the histone deacetylase core complex. MBD3 mediates the association of MTA2 with the core histone deacetylase complex. MBD3 does not directly bind methylated DNA but is highly related to MBD2, a polypeptide that binds to methylated DNA and has been reported to possess demethylase activity. MBD2 interacts with the NuRD complex and directs the complex to methylated DNA. NuRD may provide a means of gene silencing by DNA methylation. PMID:10444591

Joint NuSTAR and IRIS observation of a microflaring active region

NASA Astrophysics Data System (ADS)

Hannah, I. G.; Kleint, L.; Krucker, S.; Glesener, L.; Grefenstette, B.

2017-12-01

We present observations of a weakly microflaring active region observed in X-rays with NuSTAR, UV with IRIS and EUV with SDO/AIA. NuSTAR was pointed at this unnamed active region near the East limb between 23:27UT and 23:37UT 26-July-2016, finding mostly quiescent emission except for a small microflare about 23:35UT. The NuSTAR spectrum for the pre-microflare time (23:27UT to 23:34UT) is well fitted by a single thermal component of about 3MK and combined with SDO/AIA we can determine the differential emission measure (DEM), finding it, as expected, drops very sharply to higher temperatures. During the subsequent microflare, the increase in NuSTAR counts matches a little brightening loop observed with IRIS SJI 1400Å and SDO/AIA. Fortuitously the IRIS slit crosses this microflaring loop and we find an increased emission in Si IV 1394Å, Si IV 1403Å and O IV 1402Å but only average line widths and velocities. The NuSTAR microflare spectrum shows heating to higher temperatures and also allows us to investigate the energetics of this event.

The Double Beta Decay of NEODYMIUM-150 and Molybdenum -100

NASA Astrophysics Data System (ADS)

Nelson, Matthew Alan

1995-01-01

The double beta decays of ^{150 }Nd and ^{100}Mo were studied in a Time Projection Chamber (TPC) located at an underground site at Hoover Dam. Studies of 6286.6 h of data obtained from 15.48 g of Nd_2O _3 enriched to 91% in ^{150 }Nd reveal a two-neutrino half-life of T _sp{1/2}{2nu}=(6.27_sp {-.049}{+.049}+/-1.2)times10 ^{18} y at the 90% confidence level, and 90% CL half-life limits for the zero-neutrino and majoron decay channels of T_sp{1/2 }{0nu}>1.10times10^{21 } y, and T_sp{1/2} {0nu,chi}>3.30times10^ {20} y, respectively. Similar studies on 3274.7 h of data from a 16.7 g sample of metallic Mo enriched to 97.4% in ^{100}Mo resulted in measurements of T_sp{1/2 }{2nu}=(6.59_sp{-0.51} {+0.52}+/-1.3)times10^{1 8} {rm y}, T_sp {1/2}{0nu}>1.12times10^ {21} {rm y and} T _sp{1/2}{0nu,chi}>4.07 times10^{20} y, all at the 90% CL.

Five years of searches for point sources of astrophysical neutrinos with the AMANDA-II neutrino telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Achterberg, A.; Duvoort, M. R.; Heise, J.

2007-05-15

We report the results of a five-year survey of the northern sky to search for point sources of high energy neutrinos. The search was performed on the data collected with the AMANDA-II neutrino telescope in the years 2000 to 2004, with a live time of 1001 days. The sample of selected events consists of 4282 upward going muon tracks with high reconstruction quality and an energy larger than about 100 GeV. We found no indication of point sources of neutrinos and set 90% confidence level flux upper limits for an all-sky search and also for a catalog of 32 selectedmore » sources. For the all-sky search, our average (over declination and right ascension) experimentally observed upper limit {phi}{sup 0}=((E/1 TeV)){sup {gamma}}{center_dot}(d{phi}/dE) to a point source flux of muon and tau neutrino (detected as muons arising from taus) is {phi}{sub {nu}{sub {mu}}+{nu}{sub {mu}}{sup 0}}+{phi}{sub {nu}{sub {tau}}+{nu}{sub {tau}}}{sup 0}=11.1x 10{sup -11} TeV{sup -1} cm{sup -2} s{sup -1}, in the energy range between 1.6 TeV and 2.5 PeV for a flavor ratio {phi}{sub {nu}{sub {mu}}+{nu}{sub {mu}}{sup 0}}/{phi}{sub {nu}{sub {tau}}+{nu}{sub {tau}}}{sup 0}=1 and assuming a spectral index {gamma}=2. It should be noticed that this is the first time we set upper limits to the flux of muon and tau neutrinos. In previous papers we provided muon neutrino upper limits only neglecting the sensitivity to a signal from tau neutrinos, which improves the limits by 10% to 16%. The value of the average upper limit presented in this work corresponds to twice the limit on the muon neutrino flux {phi}{sub {nu}{sub {mu}}+{nu}{sub {mu}}}{sup 0}=5.5x10{sup -11} TeV{sup -1} cm{sup -2} s{sup -1}. A stacking analysis for preselected active galactic nuclei and a search based on the angular separation of the events were also performed. We report the most stringent flux upper limits to date, including the results of a detailed assessment of systematic uncertainties.« less

Predicting the Starquakes in PSR J0537-6910

NASA Technical Reports Server (NTRS)

Middleditch, J.; Marshall, F. E.; Wang, Q. D.; Gotthelf, E. V.; Zhang, W.

2007-01-01

We report the results of more than seven years of monitoring of PSR J0537-6910, the 16 ms pulsar in the Large Magellanic Cloud, using data acquired with the Rossi X-ray Timing Explorer. During this campaign the pulsar experienced 22 sudden increases in frequency ("glitches" - 21 with increases of at least eight microHz) amounting to a total gain of over six parts per million of rotation frequency superposed on its gradual spindown of nu-dot = -2 x 10(exp -l0) Hz /s. The time interval from one glitch to the next obeys a strong linear correlation to the amplitude of the first glitch, with a mean slope of about 400 days per part per million (6.5 days per micro Hz), such that these intervals can be predicted to within a few days, an accuracy which has never before been seen in any other pulsar. There appears to be an upper limit of approximately 40 micro Hz for the size of glitches in all pulsars, with the 1999 April glitch of PSR J0537-6910 as the largest so far. The change of its spindown across the glitches, delta (nu-dot), appears to have the same hard lower limit of -1.5 x 10 (exp -13) Hz/s, as, again, that observed in all other pulsars. The spindown continues to increase in the long term, nu-dot = -10(exp -21) Hz / s(exp 2), and thus the timing age of PSR 505374910 (-0.5 nu nu-dot (exp -1) continues to decrease at a rate of nearly one year every year, consistent with movement of its magnetic moment away from its rotational axis by one radian every 10,000 years, or about one meter per year. PSR J0537-6910 was likely to have been born as a nearly-aligned rotator spinning at 75-80 Hz, with a absolute value of nu considerably smaller than its current value of 2x 10(exp -10) Hz per second. Its pulse profile consists of a single pulse which is found to be flat at its peak for at least 0.02 cycles. Glitch activity may grow exponentially with a timescale of 170 years nu nu-dot ((nu nu-dot)(sub crab))exp -l in all young pulsars.

Electron correlations in partially filled lowest and excited Landau levels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wojs, Arkadiusz

2001-03-15

The electron correlations near the half-filling of the lowest and excited Landau levels (LL's) are studied using numerical diagonalization. It is shown that in the low-lying states electrons avoid pair states with relative angular momenta R corresponding to positive anharmonicity of the interaction pseudopotential V(R). In the lowest LL, the superharmonic behavior of V(R) causes Laughlin correlations (avoiding pairs with R=1) and the Laughlin-Jain series of incompressible ground states. In the first excited LL, V(R) is harmonic at short range and a different series of incompressible states results. Similar correlations occur in the paired Moore-Read {nu}=5/2 state and in themore » {nu}=7/3 and 8/3 states, all having small total parentage from R=1 and 3 and large parentage from R=5. The {nu}=7/3 and 8/3 states are different from Laughlin {nu}=1/3 and 2/3 states and, in finite systems, occur at a different LL degeneracy (flux). The series of Laughlin-correlated states of electron pairs at {nu}=2+2/(q{sub 2}+2)=8/3, 5/2, 12/5, and 7/3 is proposed, although only in the {nu}=5/2 state pairing has been confirmed numerically. In the second excited LL, V(R) is subharmonic at short range and (near the half-filling) the electrons group into spatially separated larger {nu}=1 droplets to minimize the number of strongly repulsive pair states at R=3 and 5.« less

A Suzaku Search for Nonthermal Emission at Hard X-Ray Energies in the Coma Cluster

DTIC Science & Technology

2008-09-01

monochromatic fluxes FR(νR), FX (νX) at frequencies νR , νX, for a power-law distribution of electrons, from which we can derive an expression for the magnetic...field as B = C(p)(1 + z)(p+5)/(p+1) ( FR FX )2/(p+1) ( νR νX )(p−1)/(p+1) , (14) where p is the index of the electron distribution N (E) ∝ E−p and is...IN THE COMA CLUSTER 1711 like NuStar,10 Astro -H (previously NeXT),11 and Simbol-X.12 If the IC emission is localized, then our joint fitting

Principles of Metamorphic Petrology

NASA Astrophysics Data System (ADS)

Williams, Michael L.

2009-05-01

The field of metamorphic petrology has seen spectacular advances in the past decade, including new X-ray mapping techniques for characterizing metamorphic rocks and minerals, new internally consistent thermobarometers, new software for constructing and viewing phase diagrams, new methods to date metamorphic processes, and perhaps most significant, revised petrologic databases and the ability to calculate accurate phase diagrams and pseudosections. These tools and techniques provide new power and resolution for constraining pressure-temperature (P-T) histories and tectonic events. Two books have been fundamental for empowering petrologists and structural geologists during the past decade. Frank Spear's Metamorphic Phase Equilibria and Pressure-Temperature-Time Paths, published in 1993, builds on his seminal papers to provide a quantitative framework for P-T path analysis. Spear's book lays the foundation for modern quantitative metamorphic analysis. Cees Passchier and Rudolph Trouw's Microtectonics, published in 2005, with its superb photos and figures, provides the tools and the theory for interpreting deformation textures and inferring deformation processes.

Litho-tectonic mapping of the North Afar region from Sentinel-2A multispectral imagery and ALOS AW3D30 digital elevation data: Controls on Danakil-Nubia plate motion between the Erta'Ale ridge and the Gulf of Zula

NASA Astrophysics Data System (ADS)

Hartnady, Chris; Hartnady, Michael; Wise, Edward; Blake, Dylan; McGibbon, David; Hay, E. Rowena

2017-04-01

The Danakil Depression in the North Afar region of Ethiopia reaches elevations deeper than 120 m below sea level and contains a Pleistocene-Holocene evaporite sequence currently investigated for potash mineral deposits. Separated from the main Ethiopian escarpment by the Dogua horst mountains, the asymmetric half-graben is bordered on its western (Nubian) side by the active, normal Main Danakil Rift-border Fault (MDRF). Above the MDRF, a series of piedmont alluvial fans (bajadas) fringes the Dogua Horst, emanating from a series of wadi catchments between the larger perennial rivers (Ragali, Saba) that drain from the high (>2000 m) Ethiopian Plateau. On its eastern side, the Danakil block contains Proterozoic-Palaeozoic sequences correlated with similar units in the Dogua range, and forms a microplate rotating independently between the larger Nubian and Arabian plates (McClusky et al., 2010). An understanding of the sedimentary and tectonic evolution of the Danakil-Nubia (DA-NU) plate system is crucial to the beneficial development of fresh groundwater resources and to an assessment of seismotectonic and volcanic geohazards in the area. Between the Mt Alid caldera in the Dandeiro graben and the Erta'Ale crater in the south Danakil, the rate of present-day DA-NU motion is 10.9 - 13.5 mm/yr, with direction azimuths N106E- N096E (after Schettino et al., 2016). DA-NU relative motion is focussed along the east-dipping MDRF in the Danakil but switches to an eastern (west-dipping) rift-border normal fault in the Dandiero, a northward extension of the Renda-Maglalla-Coma graben, separating the Dogua Horst from the main part of the NU plate. This change in rifting asymmetry occurs across a WNW/ESE-striking zone of basement faulting that terminates the Dogua Horst and functions as a left-stepping proto-transform fault zone, across the NNW direction of DA-NU proto-rift propagation. From 13-channel multispectral data of the European Space Agency satellite Sentinel-2A, a false-colour composite image, centred about MDRF and covering a wide region across the Ethiopia-Eritrea border, was created by combination of selected spectral band-ratios. This Sentinel-2A-based lithological mapping is integrated with the new ALOS AW3D30 digital elevation model, providing geomorphometric analysis and morphotectonic interpretations that allow 1) revision of previous fault-zone mapping, 2) seismotectonic contextualization of the earthquake record, and 3) improved discrimination of volcanic units and centres, both basaltic and silicic, along the northward propagating DA-NU rift zone. References McClusky, S., et al., 2010. Kinematics of the southern Red Sea-Afar Triple Junction and implications for plate dynamics. Geophys. Res. Lett., 37, L05301, doi:10.1029/2009GL041127 Schettino, A., Macchiavelli, C., Pierantoni, P.P., Zanoni, D., and Rasul, N., 2016. Recent kinematics of the tectonic plates surrounding the Red Sea and Gulf of Aden. Geophys. J. Int., 207, 457-480, doi: 10.1093/gji/gg

The NuMI neutrino beam

NASA Astrophysics Data System (ADS)

Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; Barish, B.; Barr, G.; Barrett, W. L.; Bernstein, R. H.; Biggs, J.; Bishai, M.; Blake, A.; Bocean, V.; Bock, G. J.; Boehnlein, D. J.; Bogert, D.; Bourkland, K.; Cao, S. V.; Castromonte, C. M.; Childress, S.; Choudhary, B. C.; Coelho, J. A. B.; Cobb, J. H.; Corwin, L.; Crane, D.; Cravens, J. P.; Cronin-Hennessy, D.; Ducar, R. J.; De Jong, J. K.; Devan, A. V.; Devenish, N. E.; Diwan, M. V.; Erwin, A. R.; Escobar, C. O.; Evans, J. J.; Falk, E.; Feldman, G. J.; Fields, T. H.; Ford, R.; Frohne, M. V.; Gallagher, H. R.; Garkusha, V.; Gomes, R. A.; Goodman, M. C.; Gouffon, P.; Graf, N.; Gran, R.; Grossman, N.; Grzelak, K.; Habig, A.; Hahn, S. R.; Harding, D.; Harris, D.; Harris, P. G.; Hartnell, J.; Hatcher, R.; Hays, S.; Heller, K.; Holin, A.; Huang, J.; Hylen, J.; Ibrahim, A.; Indurthy, D.; Irwin, G. M.; Isvan, Z.; Jaffe, D. E.; James, C.; Jensen, D.; Johnstone, J.; Kafka, T.; Kasahara, S. M. S.; Koizumi, G.; Kopp, S.; Kordosky, M.; Kreymer, A.; Lang, K.; Laughton, C.; Lefeuvre, G.; Ling, J.; Litchfield, P. J.; Loiacono, L.; Lucas, P.; Mann, W. A.; Marchionni, A.; Marshak, M. L.; Mayer, N.; McGivern, C.; Medeiros, M. M.; Mehdiyev, R.; Meier, J. R.; Messier, M. D.; Michael, D. G.; Milburn, R. H.; Miller, J. L.; Miller, W. H.; Mishra, S. R.; Moed Sher, S.; Moore, C. D.; Morfín, J.; Mualem, L.; Mufson, S.; Murgia, S.; Murtagh, M.; Musser, J.; Naples, D.; Nelson, J. K.; Newman, H. B.; Nichol, R. J.; Nowak, J. A.; O`Connor, J.; Oliver, W. P.; Olsen, M.; Orchanian, M.; Osprey, S.; Pahlka, R. B.; Paley, J.; Para, A.; Patterson, R. B.; Patzak, T.; Pavlović, Ž.; Pawloski, G.; Perch, A.; Peterson, E. A.; Petyt, D. A.; Pfützner, M. M.; Phan-Budd, S.; Plunkett, R. K.; Poonthottathil, N.; Prieto, P.; Pushka, D.; Qiu, X.; Radovic, A.; Rameika, R. A.; Ratchford, J.; Rebel, B.; Reilly, R.; Rosenfeld, C.; Rubin, H. A.; Ruddick, K.; Sanchez, M. C.; Saoulidou, N.; Sauer, L.; Schneps, J.; Schoo, D.; Schreckenberger, A.; Schreiner, P.; Shanahan, P.; Sharma, R.; Smart, W.; Smith, C.; Sousa, A.; Stefanik, A.; Tagg, N.; Talaga, R. L.; Tassotto, G.; Thomas, J.; Thompson, J.; Thomson, M. A.; Tian, X.; Timmons, A.; Tinsley, D.; Tognini, S. C.; Toner, R.; Torretta, D.; Trostin, I.; Tzanakos, G.; Urheim, J.; Vahle, P.; Vaziri, K.; Villegas, E.; Viren, B.; Vogel, G.; Webber, R. C.; Weber, A.; Webb, R. C.; Wehmann, A.; White, C.; Whitehead, L.; Whitehead, L. H.; Wojcicki, S. G.; Wong-Squires, M. L.; Yang, T.; Yumiceva, F. X.; Zarucheisky, V.; Zwaska, R.

2016-01-01

This paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important design details of individual components are described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

Psychological and Ethical Considerations Concerning the Debreather and Assisted Suicide: A Commentary on Ogden

ERIC Educational Resources Information Center

Kleespies, Phillip M.

2010-01-01

This article offers a commentary on the report by Russel Ogden (2010/this issue) on the use of the "debreather" for suicide assistance by the NuTech (or New Technologies for Self-Deliverance) program. The emergence of NuTech is set within its historical and political context. Nu Tech is criticized for its anarchic and extreme advocacy of…

Cloud Inhomogeneity from MODIS

NASA Technical Reports Server (NTRS)

Oreopoulos, Lazaros; Cahalan, Robert F.

2004-01-01

Two full months (July 2003 and January 2004) of MODIS Atmosphere Level-3 data from the Terra and Aqua satellites are analyzed in order to characterize the horizontal variability of cloud optical thickness and water path at global scales. Various options to derive cloud variability parameters are discussed. The climatology of cloud inhomogeneity is built by first calculating daily parameter values at spatial scales of l degree x 1 degree, and then at zonal and global scales, followed by averaging over monthly time scales. Geographical, diurnal, and seasonal changes of inhomogeneity parameters are examined separately for the two cloud phases, and separately over land and ocean. We find that cloud inhomogeneity is weaker in summer than in winter, weaker over land than ocean for liquid clouds, weaker for local morning than local afternoon, about the same for liquid and ice clouds on a global scale, but with wider probability distribution functions (PDFs) and larger latitudinal variations for ice, and relatively insensitive to whether water path or optical thickness products are used. Typical mean values at hemispheric and global scales of the inhomogeneity parameter nu (roughly the mean over the standard deviation of water path or optical thickness), range from approximately 2.5 to 3, while for the inhomogeneity parameter chi (the ratio of the logarithmic to linear mean) from approximately 0.7 to 0.8. Values of chi for zonal averages can occasionally fall below 0.6 and for individual gridpoints below 0.5. Our results demonstrate that MODIS is capable of revealing significant fluctuations in cloud horizontal inhomogenity and stress the need to model their global radiative effect in future studies.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Price, H.L.

Much of the polymer composites industry is built around the thermochemical conversion of raw material into useful composites. The raw materials (molding compound, prepreg) often are made up of thermosetting resins and small fibers or particles. While this conversion can follow a large number of paths, only a few paths are efficient, economical and lead to desirable composite properties. Processing instrument (P/I) technology enables a computer to sense and interpret changes taking place during the cure of prepreg or molding compound. P/I technology has been used to make estimates of gel time and cure time, thermal diffusivity measurements and transitionmore » temperature measurements. Control and sensing software is comparatively straightforward. The interpretation of results with appropriate software is under development.« less

Apical Transportation, Centering Ability, and Cleaning Effectiveness of Reciprocating Single-file System Associated with Different Glide Path Techniques.

PubMed

de Carvalho, Guilherme Moreira; Sponchiado Junior, Emílio Carlos; Garrido, Angela Delfina Bittencourt; Lia, Raphael Carlos Comelli; Garcia, Lucas da Fonseca Roberti; Marques, André Augusto Franco

2015-12-01

The aim of this study was to evaluate the apical transportation, the centering ability, and the cleaning effectiveness of a reciprocating single-file system associated to different glide path techniques. The mesial root canals of 52 mandibular molars were randomly distributed into 4 groups (n = 13) according to the different glide path techniques used before biomechanical preparation with Reciproc System (RS): KF/RS (sizes 10 and 15 K-files), NGP/RS (no glide path, only reciprocating system), PF/RS (sizes 13, 16, and 19 PathFile instruments), and NP (no preparation). Cone-beam computed tomography analysis was performed before and after instrumentation for apical third images acquisition. Apical transportation and its direction were evaluated by using the formula D = (X1 - X2) - (Y1 - Y2), and the centering ability was analyzed by the formula CC = (X1 - X2/Y1 - Y2 or Y1 - Y2/X1 - X2). The samples were submitted to histologic processing and analyzed under a digital microscope for debris quantification. The values were statistically analyzed (Kruskal-Wallis, the Dunn multiple comparisons test, P < .05). All groups had similar apical transportation values, with no significant difference among them (P > .05). Groups had a tendency toward transportation in the mesial direction. No technique had perfect centering ability (=1.0), with no significant difference among them. KF/RS had larger amount of debris, with statistically significant difference in comparison with NGP/RS (P > .05). The different glide path techniques promoted minimal apical transportation, and the reciprocating single-file system tested remained relatively centralized within the root canal. Also, the different techniques interfered in the cleaning effectiveness of the reciprocating system. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

First NuSTAR Observations of the BL Lac-Type Blazar PKS 2155-304: Constraints on the Jet Content and Distribution of Radiating Particles

NASA Technical Reports Server (NTRS)

Madejski, G. M.; Nalewajko, K.; Madsen, K. K.; Chiang, J.; Balokovic, M.; Paneque, D.; Furniss, A. K.; Hayashida, M.; Urry, C. M.; Sikora, M.;

Plasmid-mediated AmpC-type beta-lactamase isolated from Klebsiella pneumoniae confers resistance to broad-spectrum beta-lactams, including moxalactam.

PubMed Central

Horii, T; Arakawa, Y; Ohta, M; Ichiyama, S; Wacharotayankun, R; Kato, N

1993-01-01

Klebsiella pneumoniae NU2936 was isolated from a patient and was found to produce a plasmid-encoded beta-lactamase (MOX-1) which conferred resistance to broad spectrum beta-lactams, including moxalactam, flomoxef, ceftizoxime, cefotaxime, and ceftazidime. Resistance could be transferred from K. pneumoniae NU2936 to Escherichia coli CSH2 by conjugation with a transfer frequency of 5 x 10(-7). The structural gene of MOX-1 (blaMOX-1) was cloned and expressed in E. coli HB101. The MIC of moxalactam for E. coli HB101 producing MOX-1 was > 512 micrograms/ml. The apparent molecular mass and pI of this enzyme were calculated to be 38 kDa and 8.9, respectively. Hg2+ and Cu2+ failed to block enzyme activity, and the presence of EDTA in the reaction buffer did not reduce the enzyme activity. However, clavulanate and cloxacillin, serine beta-lactamase inhibitors, inhibited the enzyme activity competitively (Kis = 5.60 and 0.35 microM, respectively). The kinetic study of MOX-1 suggested that it effectively hydrolyzed broad-spectrum beta-lactams. A hybridization study confirmed that blaMOX-1 is encoded on a large resident plasmid (pRMOX1; 180 kb) of strain NU2936. By deletion analysis, the functional region was localized within a 1.2-kb region of the plasmid. By amino acid sequencing, 18 of 33 amino acid residues at the N terminus of MOX-1 were found to be identical to those of Pseudomonas aeruginosa AmpC. These findings suggest that MOX-1 is a plasmid-mediated AmpC-type beta-lactamase that provides enteric bacteria resistance to broad-spectrum beta-lactams, including moxalactam. Images PMID:8517725

GRANULATION IN RED GIANTS: OBSERVATIONS BY THE KEPLER MISSION AND THREE-DIMENSIONAL CONVECTION SIMULATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mathur, S.; Hekker, S.; Trampedach, R.

2011-11-10

The granulation pattern that we observe on the surface of the Sun is due to hot plasma rising to the photosphere where it cools down and descends back into the interior at the edges of granules. This is the visible manifestation of convection taking place in the outer part of the solar convection zone. Because red giants have deeper convection zones than the Sun, we cannot a priori assume that their granulation is a scaled version of solar granulation. Until now, neither observations nor one-dimensional analytical convection models could put constraints on granulation in red giants. With asteroseismology, this studymore » can now be performed. We analyze {approx}1000 red giants that have been observed by Kepler during 13 months. We fit the power spectra with Harvey-like profiles to retrieve the characteristics of the granulation (timescale {tau}{sub gran} and power P{sub gran}). We search for a correlation between these parameters and the global acoustic-mode parameter (the position of maximum power, {nu}{sub max}) as well as with stellar parameters (mass, radius, surface gravity (log g), and effective temperature (T{sub eff})). We show that {tau}{sub eff}{proportional_to}{nu}{sup -0.89}{sub max} and P{sub gran}{proportional_to}{nu}{sup -1.90}{sub max}, which is consistent with the theoretical predictions. We find that the granulation timescales of stars that belong to the red clump have similar values while the timescales of stars in the red giant branch are spread in a wider range. Finally, we show that realistic three-dimensional simulations of the surface convection in stars, spanning the (T{sub eff}, log g) range of our sample of red giants, match the Kepler observations well in terms of trends.« less

Calculating Path-Dependent Travel Time Prediction Variance and Covariance fro a Global Tomographic P-Velocity Model

NASA Astrophysics Data System (ADS)

Ballard, S.; Hipp, J. R.; Encarnacao, A.; Young, C. J.; Begnaud, M. L.; Phillips, W. S.

2012-12-01

Seismic event locations can be made more accurate and precise by computing predictions of seismic travel time through high fidelity 3D models of the wave speed in the Earth's interior. Given the variable data quality and uneven data sampling associated with this type of model, it is essential that there be a means to calculate high-quality estimates of the path-dependent variance and covariance associated with the predicted travel times of ray paths through the model. In this paper, we describe a methodology for accomplishing this by exploiting the full model covariance matrix and show examples of path-dependent travel time prediction uncertainty computed from SALSA3D, our global, seamless 3D tomographic P-velocity model. Typical global 3D models have on the order of 1/2 million nodes, so the challenge in calculating the covariance matrix is formidable: 0.9 TB storage for 1/2 of a symmetric matrix, necessitating an Out-Of-Core (OOC) blocked matrix solution technique. With our approach the tomography matrix (G which includes Tikhonov regularization terms) is multiplied by its transpose (GTG) and written in a blocked sub-matrix fashion. We employ a distributed parallel solution paradigm that solves for (GTG)-1 by assigning blocks to individual processing nodes for matrix decomposition update and scaling operations. We first find the Cholesky decomposition of GTG which is subsequently inverted. Next, we employ OOC matrix multiplication methods to calculate the model covariance matrix from (GTG)-1 and an assumed data covariance matrix. Given the model covariance matrix, we solve for the travel-time covariance associated with arbitrary ray-paths by summing the model covariance along both ray paths. Setting the paths equal and taking the square root yields the travel prediction uncertainty for the single path.

Laplace approximation for Bessel functions of matrix argument

NASA Astrophysics Data System (ADS)

Butler, Ronald W.; Wood, Andrew T. A.

2003-06-01

We derive Laplace approximations to three functions of matrix argument which arise in statistics and elsewhere: matrix Bessel A[nu]; matrix Bessel B[nu]; and the type II confluent hypergeometric function of matrix argument, [Psi]. We examine the theoretical and numerical properties of the approximations. On the theoretical side, it is shown that the Laplace approximations to A[nu], B[nu] and [Psi] given here, together with the Laplace approximations to the matrix argument functions 1F1 and 2F1 presented in Butler and Wood (Laplace approximations to hyper-geometric functions with matrix argument, Ann. Statist. (2002)), satisfy all the important confluence relations and symmetry relations enjoyed by the original functions.

Temperature dependence of nu3 and nu4 bandwidths and complex refractive indices for crystalline methane

NASA Technical Reports Server (NTRS)

Ngoh, M. A.; Khanna, R. K.; Fox, K.

1993-01-01

Infrared spectra of thin films of pure CH4 have been measured for a range of temperatures from 22 to 68 K. The bandwidth for the fundamental nu3 near 3000/cm varies from 12.7 to 33.2/cm, while that for nu4 near 1300/cm varies from 6.2 to 16.0/cm. The real and imaginary parts of the index of refraction also exhibit significant dependence on temperature. These broadband measurements at low temperatures are useful for an understanding of clouds and hazes in the atmosphere of Uranus, clouds and ices in the atmosphere of Titan, and ices on the surfaces of Pluto and Triton.

Threats and Challenges in Reconfigurable Hardware Security

DTIC Science & Technology

2008-07-01

Same as Report (SAR) 18. NUMBER OF PAGES 12 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE...g e F P G A MemoryMemory Codec A/DD/A F P G A B o a rd System Developers Avnet, Digilent, NuHorizons Application Development Stage Deployment...Rohatgi, and B . Sunar. Trojan detection using IC fingerprinting. In Proceedings of IEEE Symposium on Security and Privacy, 2007. [3] K. Austin. Data

Beauty Baryons at CDF and DO

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kryemadhi, Abaz

The results from Tevatron in the baryonic sector are presented. The lifetime of {lambda}b {yields} J/{psi}{lambda}, the observation of hadronic decay of {lambda}b {yields} {lambda}c{pi}, the semileptonic decays of {lambda}b {yields} {lambda}c{mu}{nu}, the hadronization of the b-baryons, and the {lambda}b decays to {lambda}b {yields} p{pi} and {lambda}b {yields} pK are discussed. These measurements paint a nice picture of our understanding of the beauty baryons.

Persistence of growth stunting in a Peruvian high altitude community, 1964-1999.

PubMed

Pawson, Ivan G; Huicho, Luis

2010-01-01

The growth of children living in Nuñoa, a Peruvian high-altitude community, was studied over a 35-year period using data collected in 1964 and 1999. There had been evidence of a secular trend in growth in the mid-1980s, but this was before a period of sociopolitical upheaval lasting until the late 1990s partly linked to the activities of the Shining Path group and the Peruvian government's response. Anthropometric data for 576 children examined in 1964-1966 were compared with data from 361 children examined in 1999. Data were converted to Z Scores using NCHS/WHO reference standards. Compared with the 1964 cohort, boys in 1999 had marginally greater height Z Scores, but among females, the trend was reversed. Stunting prevalence had decreased from 1964 levels, but still approached 60% in both sexes, among the highest rates recorded for a modern world population. The prevalence of low weight for height was less than expected, possibly because of the compensatory effect of enlarged chest diameter. This anatomical feature may represent the effect of chronic hypoxic stress, causing growth of the chest cavity at the expense of growth in height. In view of modest improvements during the late 1980s in this population, we believe that the relatively poor growth status of children a decade later may result from food disruption associated with later political instability. Compared with children in a nearby community, which benefits from the socioeconomic infrastructure associated with a large copper mine, Nuñoa children continue to fare relatively poorly.

FTIR study of CO2 and H2O/CO2 nanoparticles and their temporal evolution at 80 K.

PubMed

Taraschewski, M; Cammenga, H K; Tuckermann, R; Bauerecker, S

2005-04-21

Fourier transform infrared (FTIR) spectroscopy combined with a long-path collisional cooling cell was used to investigate the temporal evolution of CO2 nanoparticles and binary H2O/CO2 nanocomposites in the aerosol phase at 80 K. The experimental conditions for the formation of different CO2 particle shapes as slab, shell, sphere, cube, and needle have been studied by comparison with calculated data from the literature. The H2O/CO2 nanoparticles were generated with a newly developed multiple-pulse injection technique and with the simpler flow-in technique. The carbon dioxide nu3-vibration band at 2360 cm(-1) and the water ice OH-dangling band at 3700 cm(-1) were used to study the evolution of structure, shape, and contact area of the nanocomposites over 150 s. Different stages of binary nanocomposites with primary water ice cores were identified dependent on the injected CO2 portion: (a) disordered (amorphous) CO2 slabs on water particle surfaces, (b) globular crystalline CO2 humps sticking on the water cores, and (c) water cores being completely enclosed in bigger predominantly crystalline CO2 nanoparticles. However, regular CO2 shell structures on primary water particles showing both longitudinal (LO) and transverse (TO) optical mode features of the nu3-vibration band could not be observed. Experiments with reversed nucleation order indicate that H2O/CO2 composite particles with different initial structures evolve toward similar molecular nanocomposites with separated CO2 and H2O regions.

Anti-endotoxic shock effects of cyproheptadine in rats.

PubMed

Wang, Lizan; Zhang, Qingzhu; Hu, Xiuzhou; Lun, Ning; Wang, Baosheng; Zhu, Fanhe

2002-03-01

To investigate the antagonistic effect and mechanism of the effect of cyproheptadine (Cyp) on endotoxic shock in rats. Endotoxic shock was produced in rats by i.v. injection of lipopolysaccharides (LPS) (5 mg/kg). Tumor necrosis factor (TNF(alpha)) mRNA expression was assessed by Northern blot. Plasma TNF(alpha) content was measured by radioimmunoassay. Plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were measured. The intracellular free calcium concentration ([Ca(2+)](i)) in single endothelial cells was determined by laser scanning confocal microscopy (LSCM). Cyp 5 mg/kg injected immediately after i.v. LPS raised the mean arterial blood pressure (MABP) of shocked rats and improved their 24 h survival rate. Meanwhile, Cyp markedly decreased TNF(alpha) mRNA levels in rat liver (18 +/- 10 vs. LPS + saline 38 +/- 10, P < 0.01) as well as plasma TNF(alpha) content [(7.8 +/- 2.4) microg/L vs. LPS + saline (21.5 +/- 3.2) microg/L, P < 0.01)]. It enhanced plasma SOD activity [(1037.2 +/- 112.8) NU/L vs LPS + saline (615.4 +/- 92.6) NU/L, P < 0.01], reduced the MDA content [(5.2 +/- 1.1) micromol/L vs. LPS + saline (9.8 +/- 1.5) micromol/L, P < 0.01], and inhibited TNF(alpha)-induced [Ca(2+)](i) elevation. Cyp exerts an anti-endotoxic shock effect by inhibiting TNF(alpha) gene expression, enhancing SOD activity, reducing lipid peroxidation, and preventing [Ca(2+)](i) overload.

DOE Office of Scientific and Technical Information (OSTI.GOV)

MacKay,W.W.

For a ring like RHIC with two full Siberian snakes on opposite sides of the ring, the spin tune for a flat orbit will be 1/2 if the snake rotation axes are perpendicular, {Delta}{phi} = {phi}{sub 9}-{phi}{sub 3} = {pi}/2. Here {phi}{sup 9} and {phi}{sub 3} are respectively the direction of the rotation axes of the 9 o'clock and 3 o'clock snakes relative to the design trajectory as shown in Figure 1. If the two snakes are slightly detuned by the same amount such that the rotation axes are no longer perpendicular, then the deviation of the closed-orbit spin tunemore » {nu}{sub 0} from 1/2 is given by {Delta}{nu}{sub 0} {approx_equal} ({Delta}{mu}){sup 2}/4{pi} cosG{gamma}{pi} - 2{Delta}{phi}/{pi} {approx_equal} 2{Delta}{phi}/180{sup o} with G{gamma} at a half integer, and where {Delta}{mu} is the deviation of snake rotation angle from 180{sup o}. It should be noted that there is a sign ambiguity in {Delta}{mu}{sub 0} since a spin tune of 0.495 is also a spin tune of 0.505, depending on the direction taken along the stable spin axis. In order to understand the effect of energy scaling on the snake axis direction, I have integrated the trajectory and spin rotation through a model of a RHIC snake (bi9-snk7) and found the energy (U) dependence of the snake axis angle {phi}{sub 9} and rotation angle {mu} as shown. A {approx_equal} p{sup -2} scaling of errors is typical in helical snakes. To first order, the orbit excursion drops as p{sup -1} and the spin precessions about transverse fields increase as {gamma} giving an approximate cancellation with energy, so we do not expect much change during the field ramp. The next order term which comes in is primarily proportional to p{sup -2}; although naively one might expect a slight effect inversely proportional to the velocity since {gamma}/p {proportional_to} c/{nu} {approx_equal} 1 + 1/2{gamma}{sup 2}.« less

nuSTORM Costing document

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bross, Alan D.

2013-10-01

Detailed costing of the nuSTORM conventional facilities has been done by the Fermilab Facilities Engineering Services Section (FESS) and is reported on in the nuSTORM Project Definition Report (PDR) 6-13-1. Estimates for outfitting the primary proton beam line, the target station, the pion capture/transport line and decay ring are based on either experience from existing Fermilab infrastructure (NuMI) or is based on the detailed costing exercises for DOE CD-1 approval for future experiments (mu2e and LBNE). The detector costing utilized the Euronu costing for the Neutrino Factory Magnetized Iron Neutrino Detector (MIND), extrapolations from MINOS as-built costs and from recentmore » vendor quotes. Costs included all manpower and are fully burdened (FY2013 dollars). The costs are not escalated, however, beyond the 5-year project timeline, since a project start for nuSTORM is unknown. Escalation can be estimated from various models (see Figure 1). LBNE has used the Jacob’s model to determine their cost escalation.« less

The cardiac TBX5 interactome reveals a chromatin remodeling network essential for cardiac septation

PubMed Central

Waldron, Lauren; Steimle, Jeffrey D.; Greco, Todd M.; Gomez, Nicholas C.; Dorr, Kerry M.; Kweon, Junghun; Temple, Brenda; Yang, Xinan Holly; Wilczewski, Caralynn M.; Davis, Ian J.; Cristea, Ileana M.; Moskowitz, Ivan P.; Conlon, Frank L.

2016-01-01

SUMMARY Human mutations in the cardiac transcription factor gene TBX5 cause Congenital Heart Disease (CHD), however the underlying mechanism is unknown. We report characterization of the endogenous TBX5 cardiac interactome and demonstrate that TBX5, long considered a transcriptional activator, interacts biochemically and genetically with the Nucleosome Remodeling and Deacetylase (NuRD) repressor complex. Incompatible gene programs are repressed by TBX5 in the developing heart. CHD missense mutations that disrupt the TBX5-NuRD interaction cause depression of a subset of repressed genes. Furthermore, the TBX5-NuRD interaction is required for heart development. Phylogenetic analysis showed that the TBX5-NuRD interaction domain evolved during early diversification of vertebrates, simultaneous with the evolution of cardiac septation. Collectively, this work defines a TBX5-NuRD interaction essential to cardiac development and the evolution of the mammalian heart, and when altered may contribute to human CHD. PMID:26859351

The first focused hard X-ray images of the sun with NuSTAR

DOE PAGES

Grefenstette, Brian W.; Glesener, Lindsay; Krucker, Sam; ...

2016-07-18

Here, we present results from the the first campaign of dedicated solar observations undertaken by the Nuclear Spectroscopic Telescope ARray (NuSTAR) hard X-ray (HXR) telescope. Designed as an astrophysics mission, NuSTAR nonetheless has the capability of directly imaging the Sun at HXR energies (>3 keV) with an increase in sensitivity of at least two magnitude compared to current non-focusing telescopes. In this paper we describe the scientific areas where NuSTAR will make major improvements on existing solar measurements. We report on the techniques used to observe the Sun with NuSTAR, their limitations and complications, and the procedures developed to optimizemore » solar data quality derived from our experience with the initial solar observations. These first observations are briefly described, including the measurement of the Fe K-shell lines in a decaying X-class flare, HXR emission from high in the solar corona, and full-disk HXR images of the Sun.« less

NuSTAR view of the central region of M31

NASA Astrophysics Data System (ADS)

Stiele, H.; Kong, A. K. H.

2018-04-01

Our neighbouring large spiral galaxy, the Andromeda galaxy (M31 or NGC 224), is an ideal target to study the X-ray source population of a nearby galaxy. NuSTAR observed the central region of M31 in 2015 and allows studying the population of X-ray point sources at energies higher than 10 keV. Based on the source catalogue of the large XMM-Newton survey of M31, we identified counterparts to the XMM-Newton sources in the NuSTAR data. The NuSTAR data only contain sources of a brightness comparable (or even brighter) than the selected sources that have been detected in XMM-Newton data. We investigate hardness ratios, spectra, and long-term light curves of individual sources obtained from NuSTAR data. Based on our spectral studies, we suggest four sources as possible X-ray binary candidates. The long-term light curves of seven sources that have been observed more than once show low (but significant) variability.

On Rosen's theory of gravity and cosmology

NASA Technical Reports Server (NTRS)

Barnes, R. C.

1980-01-01

Formal similarities between general relativity and Rosen's bimetric theory of gravity were used to analyze various bimetric cosmologies. The following results were found: (1) physically plausible model universes which have a flat static background metric, have a Robertson-Walker fundamental metric, and which allow co-moving coordinates do not exist in bimetric cosmology. (2) it is difficult to use the Robertson-Walker metric for both the background metric (gamma mu nu) and the fundamental metric tensor of Riemannian geometry( g mu nu) and require that g mu nu and gamma mu nu have different time dependences. (3) A consistency relation for using co-moving coordinates in bimetric cosmology was derived. (4) Certain spatially flat bimetric cosmologies of Babala were tested for the presence of particle horizons. (5) An analytic solution for Rosen's k = +1 model was found. (6) Rosen's singularity free k = +1 model arises from what appears to be an arbitary choice for the time dependent part of gamma mu nu.

Efficacy of contact lens disinfecting solutions against Staphylococcus aureus and Pseudomonas aeruginosa.

PubMed

Manuj, Kapur; Gunderson, Charlise; Troupe, John; Huber, Mary E

2006-07-01

To evaluate the disinfection properties of multipurpose contact lens disinfection solutions, based on the International Organization for Standardization (ISO) 14729 guidelines. ReNu with MoistureLoc Multi-Purpose Solution, OPTI-FREE Express with Aldox Multi-Purpose Solution, Betadine 5% sterile ophthalmic preparation solution (povidone iodine), and 0.9% normal saline solution were inoculated with strains of Staphylococcus aureus and Pseudomonas aeruginosa. Surviving bacteria were quantified at specified times. ReNu with MoistureLoc, OPTI-FREE Express, and 5% ophthalmic povidone iodine were effective in achieving a 5-log reduction in bacterial count. Additionally, all three products maintained their effectivity at 72 hours. However, ReNu with MoistureLoc and povidone iodine resulted in the greatest reduction in bacterial colonization. ReNu with MoistureLoc, OPTI-FREE Express, and 5% ophthalmic povidone iodine meet the ISO 14729 guidelines for standalone contact lens solutions. However, ReNu with MoistureLoc and 5% ophthalmic povidone iodine are most efficient in reducing and maintaining low bacterial count for a period of 72 hours.

The first focused hard X-ray images of the sun with NuSTAR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grefenstette, Brian W.; Glesener, Lindsay; Krucker, Sam

Here, we present results from the the first campaign of dedicated solar observations undertaken by the Nuclear Spectroscopic Telescope ARray (NuSTAR) hard X-ray (HXR) telescope. Designed as an astrophysics mission, NuSTAR nonetheless has the capability of directly imaging the Sun at HXR energies (>3 keV) with an increase in sensitivity of at least two magnitude compared to current non-focusing telescopes. In this paper we describe the scientific areas where NuSTAR will make major improvements on existing solar measurements. We report on the techniques used to observe the Sun with NuSTAR, their limitations and complications, and the procedures developed to optimizemore » solar data quality derived from our experience with the initial solar observations. These first observations are briefly described, including the measurement of the Fe K-shell lines in a decaying X-class flare, HXR emission from high in the solar corona, and full-disk HXR images of the Sun.« less

THE FIRST FOCUSED HARD X-RAY IMAGES OF THE SUN WITH NuSTAR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grefenstette, Brian W.; Madsen, Kristin K.; Forster, Karl

We present results from the the first campaign of dedicated solar observations undertaken by the Nuclear Spectroscopic Telescope ARray ( NuSTAR ) hard X-ray (HXR) telescope. Designed as an astrophysics mission, NuSTAR nonetheless has the capability of directly imaging the Sun at HXR energies (>3 keV) with an increase in sensitivity of at least two magnitude compared to current non-focusing telescopes. In this paper we describe the scientific areas where NuSTAR will make major improvements on existing solar measurements. We report on the techniques used to observe the Sun with NuSTAR , their limitations and complications, and the procedures developedmore » to optimize solar data quality derived from our experience with the initial solar observations. These first observations are briefly described, including the measurement of the Fe K-shell lines in a decaying X-class flare, HXR emission from high in the solar corona, and full-disk HXR images of the Sun.« less

Measurements of Tc (Q,P): Depression of the Superfluid Transition Temperature by a Heat Current Along the Lambda Line

NASA Technical Reports Server (NTRS)

Liu, Yuan-Ming; Larson, Melora; Israelsson, Ulf

1999-01-01

We report experimental measurements of Tc (Q,P) for heat currents (Q) between I1and 100 micro W/sq cm and pressure (P) between SVP and 15 bar. The measurements were performed in a normal gravity environment, using the low-gravity simulator facility at JPL without the magnet being energized. The sample pressure was controlled to 0.1 micro bar using a hot volume, and a Straty-Adams capacitive pressure gauge. The total volume of helium in the sample cell and the hot volume was held constant using a pneumatic low temperature valve. A melting curve thermometer (MCT) measured the transition temperature (Tc) with a resolution of about 10 nK through a sidewall probe of the thermal conductivity sample cell. We employed the same measurement technique and procedure described by DAS. Preliminary results indicate that Tc (Q,P) depends very little on the pressure in the pressure range between SVP and 15 bar with a variation in the amplitude of Tc(Q,P) of less than about 5% observable in this pressure range. According to the Renormalization-group theory calculation by Haussmann and Dohm, the amplitude of Tc (Q,P) has a leading pressure-dependence term proportional to xi(sub 0) (sup (1/nu)), where xi(sub 0) is the correlation-length amplitude and nu is the correlation-length exponent. Thus, a small pressure dependence of the amplitude of Tc (Q,P) is expected since xi(sub 0) is very weakly dependent on pressure between SVP and 15 bar, consistent with our measurements.

31P NMR spectroscopy studies of phospholipid metabolism in human melanoma xenograft lines differing in rate of tumour cell proliferation.

PubMed

Lyng, H; Olsen, D R; Petersen, S B; Rofstad, E K

1995-04-01

The concentration of phospholipid metabolites in tumours has been hypothesized to be related to rate of cell membrane turnover and may reflect rate of cell proliferation. The purpose of the study reported here was to investigate whether 31P NMR resonance ratios involving the phosphomonoester (PME) or phosphodiester (PDE) resonance are correlated to fraction of cells in S-phase or volume-doubling time in experimental tumours. Four human melanoma xenograft lines (BEX-t, HUX-t, SAX-t, WIX-t) were included in the study. The tumours were grown subcutaneously in male BALB/c-nu/nu mice. 31P NMR spectroscopy was performed at a magnetic field strength of 4.7 T. Fraction of cells in S-phase was measured by flow cytometry. Tumour volume-doubling time was determined by Gompertzian analysis of volumetric growth data. BEX-t and SAX-t tumours differed in fraction of cells in S-phase and volume-doubling time, but showed similar 31P NMR resonance ratios. BEX-t and WIX-t tumours showed significantly different 31P NMR resonance ratios but similar fractions of cells in S-phase. The 31P NMR resonance ratios were significantly different for small and large HUX-t tumours even though fraction of cells in S-phase and volume-doubling time did not differ with tumour volume. None of the 31P NMR resonance ratios showed significant increase with increasing fraction of cells in S-phase or significant decrease with increasing tumour volume-doubling time across the four xenograft lines.(ABSTRACT TRUNCATED AT 250 WORDS)

Secular resonances. [of asteroidal dynamics

NASA Technical Reports Server (NTRS)

Scholl, H.; Froeschle, CH.; Kinoshita, H.; Yoshikawa, M.; Williams, J. G.

1989-01-01

Theories and numerical experiments regarding secular resonances are reviewed. The basic dynamics and the positions of secular resonances are discussed, and secular perturbation theories for the nu16 resonance case, the nu6 resonance, and the nu5 resonance are addressed. What numerical experiments have revealed about asteroids located in secular resonances, the stability of secular resonances, variations of eccentricities and inclinations, and chaotic orbits is considered. Resonant transport of meteorites is discussed.

The nu sub 2 band CHD3; ground state parameters for CHD3 from combination differences

NASA Technical Reports Server (NTRS)

Jennings, D. E.; Blass, W. E.

1974-01-01

The nu sub 2 fundamental band of CHD3, centered near 2143/cm, was recorded at a resolution of 0.015-0.25/cm. Analysis of ground state combination differences yielded well-determined values for the ground state molecular parameters for CHD3. These parameters were used in the determination of the alpha and beta molecular parameters for nu sub 2.

The NuMI neutrino beam

DOE PAGES

Adamson, P.; Anderson, K.; Andrews, M.; ...

2015-10-20

Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

NuSTAR Observation of SN2017eaw

NASA Astrophysics Data System (ADS)

Grefensetette, Brian; Harrison, Fiona; Brightman, Murray

2017-05-01

Following the detection of the young Type IIp supernova SN2017eaw in NGC 6946 (ATELs #10374, #10376, #10377) and the subsequent detection of soft X-ray flux by Swift (ATEL #10380), we executed a NuSTAR DDT observation of the supernova from 2017-05-21T15:26:09 to 2017-05-22T23:36:09 corresponding to 66.5 ks of on-target time per NuSTAR telescope.

Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Timothy C.; Vermeulen, Nicolaas A.; Kim, In Soo

The synthesis of NU-1000, a highly robust mesoporous (containing pores >2 nm) metal-organic framework (MOF), can be conducted efficiently on a multigram scale from inexpensive starting materials. Tetrabromopyrene and (4-(ethoxycarbonyl)phenyl)boronic acid can easily be coupled to prepare the requisite organic strut with four metal-binding sites in the form of four carboxylic acids, while zirconyl chloride octahydrate is used as a precursor for the well-defined metal oxide clusters. NU-1000 has been reported as an excellent candidate for the separation of gases, and it is a versatile scaffold for heterogeneous catalysis. In particular, it is ideal for the catalytic deactivation of nervemore » agents, and it shows great promise as a new generic platform for a wide range of applications. Multiple post-synthetic modification protocols have been developed using NU-1000 as the parent material, making it a potentially useful scaffold for several catalytic applications. The procedure for the preparation of NU-1000 can be scaled up reliably, and it is suitable for the production of 50 g of the tetracarboxylic acid containing organic linker and 200 mg–2.5 g of NU-1000. The entire synthesis is performed without purification by column chromatography and can be completed within 10 d.« less

Evidence for the decay D0-->K(-)pi(+)pi(-)e(+)nu(e).

PubMed

Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Naik, P; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Ecklund, K M; Severini, H; Love, W; Savinov, V; Aquines, O; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F

2007-11-09

Using a 281 pb{-1} data sample collected at the psi(3770) with the CLEO-c detector, we present the first absolute branching fraction measurement of the decay D0-->K(-)pi(+)pi(-)e(+)nu(e) at a statistical significance of about 4.0 standard deviations. We find 10 candidates consistent with the decay D0-->K(-)pi(+)pi(-)e(+)nu(e). The probability that a background fluctuation accounts for this signal is less than 4.1 x 10{-5}. We find B(D0-->K(-)pi(+)pi(-)e(+)nu(e)) = [2.8{-1.1}{+1.4}(stat)+/-0.3(syst)]x10{-4}. By restricting the invariant mass of the hadronic system to be consistent with K1(1270), we obtain the product of branching fractions B(D{0}-->K{1}{-}(1270)e{+}nu{e})xB(K1-(1270)-->K{-}pi{+}pi{-})=[2.5{-1.0}{+1.3}(stat)+/-0.2(syst)]x10{-4}. Using B(K1-(1270)-->K{-}pi{+}pi{-})=(33+/-3)%, we obtain B(D{0}-->K{1}{-}(1270)e{+}nu{e})=[7.6{-3.0}{+4.1}(stat)+/-0.6(syst)+/-0.7]x10{-4}. The last error accounts for the uncertainties in the measured K1-(1270)-->K{-}pi{+}pi{-} branching fractions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Platero-Prats, Ana E.; Li, Zhanyong; Gallington, Leighanne C.

Here, we explore the dynamic structure and reactivity of Cu species supported on NU-1000. By combining pair distribution function (PDF) analysis and difference envelope density (DED) analysis ofin situsynchrotron-based X-ray scattering data, we simultaneously probe the local structure of supported Cu-species, their distribution within NU-1000 and distortions of the NU-1000 lattice under conditions relevant to catalysis and catalyst activation. Our analyses show that atomic layer deposition (ALD) of Cu in NU-1000 (Cu-AIM) leads to the formation of Cu-oxo clusters within the small pores that connect the triangular and hexagonal channels. Exposure of Cu-AIM to a reducing atmosphere at 200 °Cmore » produces metallic Cu 0of two distinct particle sizes: ~4 nm nanoparticles and small sub-nanometer clusters. The size of these nanoparticles appears to be constrained by NU-1000 pore dimensions, with evidence of the sub-nanometer clusters being bound within the triangular channels flanked by pyrene rings. This supported Cu 0–NU-1000 system is catalytically active for gas-phase ethylene hydrogenation. Exposure of the catalyst to oxidative atmosphere re-oxidises the Cu species to a Cu 2O cuprite phase. The dynamic restructuring of the system in different chemical environments underscores the importance of probing these systemsin situ.« less

Drosophila Transcription Factor Tramtrack69 Binds MEP1 To Recruit the Chromatin Remodeler NuRD ▿ †

PubMed Central

Reddy, B. Ashok; Bajpe, Prashanth Kumar; Bassett, Andrew; Moshkin, Yuri M.; Kozhevnikova, Elena; Bezstarosti, Karel; Demmers, Jeroen A. A.; Travers, Andrew A.; Verrijzer, C. Peter

2010-01-01

ATP-dependent chromatin-remodeling complexes (remodelers) are essential regulators of chromatin structure and gene transcription. How remodelers can act in a gene-selective manner has remained enigmatic. A yeast two-hybrid screen for proteins binding the Drosophila transcription factor Tramtrack69 (TTK69) identified MEP1. Proteomic characterization revealed that MEP1 is a tightly associated subunit of the NuRD remodeler, harboring the Mi2 enzymatic core ATPase. In addition, we identified the fly homolog of human Deleted in oral cancer 1 (DOC1), also known as CDK2-associated protein 1 (CDK2AP1), as a bona fide NuRD subunit. Biochemical and genetic assays supported the functional association between MEP1, Mi2, and TTK69. Genomewide expression analysis established that TTK69, MEP1, and Mi2 cooperate closely to control transcription. The TTK69 transcriptome profile correlates poorly with remodelers other than NuRD, emphasizing the selectivity of remodeler action. On the genes examined, TTK69 is able to bind chromatin in the absence of NuRD, but targeting of NuRD is dependent on TTK69. Thus, there appears to be a hierarchical relationship in which transcription factor binding precedes remodeler recruitment. PMID:20733004

Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000.

PubMed

Wang, Timothy C; Vermeulen, Nicolaas A; Kim, In Soo; Martinson, Alex B F; Stoddart, J Fraser; Hupp, Joseph T; Farha, Omar K

2016-01-01

The synthesis of NU-1000, a highly robust mesoporous (containing pores >2 nm) metal-organic framework (MOF), can be conducted efficiently on a multigram scale from inexpensive starting materials. Tetrabromopyrene and (4-(ethoxycarbonyl)phenyl)boronic acid can easily be coupled to prepare the requisite organic strut with four metal-binding sites in the form of four carboxylic acids, while zirconyl chloride octahydrate is used as a precursor for the well-defined metal oxide clusters. NU-1000 has been reported as an excellent candidate for the separation of gases, and it is a versatile scaffold for heterogeneous catalysis. In particular, it is ideal for the catalytic deactivation of nerve agents, and it shows great promise as a new generic platform for a wide range of applications. Multiple post-synthetic modification protocols have been developed using NU-1000 as the parent material, making it a potentially useful scaffold for several catalytic applications. The procedure for the preparation of NU-1000 can be scaled up reliably, and it is suitable for the production of 50 g of the tetracarboxylic acid containing organic linker and 200 mg-2.5 g of NU-1000. The entire synthesis is performed without purification by column chromatography and can be completed within 10 d.

Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes

PubMed Central

Vignali, Marissa; Steger, David J.; Neely, Kristen E.; Workman, Jerry L.

2000-01-01

We analyzed the targeting of histone acetyltransferase (HAT) complexes by DNA-binding activators during transcriptional activation and the resulting distribution of acetylated histones. An in vitro competition assay was developed to acetylate and transcribe a nucleosomal array template in the presence of excess non-specific chromatin, which mimics in vivo conditions. Stimulation of transcription from the nucleosomal array template under competitive conditions by the SAGA and NuA4 HAT complexes depended on the presence of the Gal4-VP16 activator, which recognizes sites in the promoter and directly interacts with these HATs. Importantly, the stimulation of transcription by SAGA and NuA4 depended on the presence of Gal4-VP16 during histone acetylation, and Gal4-VP16-bound nucleosomal templates were acetylated preferentially by SAGA and NuA4 relative to the competitor chromatin. While targeting of the SAGA complex led to H3 acetylation of promoter-proximal nucleosomes, targeting of the NuA4 complex led to a broader domain of H4 acetylation of >3 kbp. Thus, either promoter-proximal H3 acetylation by SAGA or broadly distributed acetylation of H4 by NuA4 activated transcription from chromatin templates. PMID:10835360

Application of 2D-Nonlinear Shallow Water Model of Tsunami by using Adomian Decomposition Method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waewcharoen, Sribudh; Boonyapibanwong, Supachai; Koonprasert, Sanoe

2008-09-01

One of the most important questions in tsunami modeling is the estimation of tsunami run-up heights at different points along a coastline. Methods for numerical simulation of tsunami wave propagation in deep and shallow seas are well developed and have been widely used by many scientists (2001-2008). In this paper, we consider a two-dimensional nonlinear shallow water model of tsunami given by Tivon Jacobson is work [1]. u{sub t}+uu{sub x}+{nu}u{sub y} -c{sup 2}(h{sub x}+(h{sub b}){sub x}) {nu}{sub t}+u{nu}{sub x}+{nu}{nu}{sub y} = -c{sup 2}(h{sub y}+(h{sub b}){sub y}) h{sub t}+(hu){sub x}+(h{nu}){sub y} = 0 g-shore, h is surface elevation and s, tmore » is time, u is velocity of cross-shore, {nu} is velocity of along-shore, h is surface elevation and h{sub b} is function of shore. This is a nondimensionalized model with the gravity g and constant reference depth H factored into c = {radical}(gH). We apply the Adomian Decompostion Method (ADM) to solve the tsunami model. This powerful method has been used to obtain explicit and numerical solutions of three types of diffusion-convection-reaction (DECR) equations. The ADM results for the tsunami model yield analytical solutions in terms of a rapidly convergent infinite power series. Symbolic computation, numerical results and graphs of solutions are obtained by Maple program.« less

An algorithm for automated ROI definition in water or epoxy-filled NEMA NU-2 image quality phantoms.

PubMed

Pierce, Larry A; Byrd, Darrin W; Elston, Brian F; Karp, Joel S; Sunderland, John J; Kinahan, Paul E

2016-01-08

Drawing regions of interest (ROIs) in positron emission tomography/computed tomography (PET/CT) scans of the National Electrical Manufacturers Association (NEMA) NU-2 Image Quality (IQ) phantom is a time-consuming process that allows for interuser variability in the measurements. In order to reduce operator effort and allow batch processing of IQ phantom images, we propose a fast, robust, automated algorithm for performing IQ phantom sphere localization and analysis. The algorithm is easily altered to accommodate different configurations of the IQ phantom. The proposed algorithm uses information from both the PET and CT image volumes in order to overcome the challenges of detecting the smallest spheres in the PET volume. This algorithm has been released as an open-source plug-in to the Osirix medical image viewing software package. We test the algorithm under various noise conditions, positions within the scanner, air bubbles in the phantom spheres, and scanner misalignment conditions. The proposed algorithm shows run-times between 3 and 4 min and has proven to be robust under all tested conditions, with expected sphere localization deviations of less than 0.2 mm and variations of PET ROI mean and maximum values on the order of 0.5% and 2%, respectively, over multiple PET acquisitions. We conclude that the proposed algorithm is stable when challenged with a variety of physical and imaging anomalies, and that the algorithm can be a valuable tool for those who use the NEMA NU-2 IQ phantom for PET/CT scanner acceptance testing and QA/QC.

Galactic Sources Detected in the NuSTAR Serendipitous Survey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tomsick, John A.; Clavel, Maïca; Chiu, Jeng-Lun

The Nuclear Spectroscopic Telescope Array (NuSTAR) provides an improvement in sensitivity at energies above 10 keV by two orders of magnitude over non-focusing satellites, making it possible to probe deeper into the Galaxy and universe. Lansbury and collaborators recently completed a catalog of 497 sources serendipitously detected in the 3–24 keV band using 13 deg{sup 2} of NuSTAR coverage. Here, we report on an optical and X-ray study of 16 Galactic sources in the catalog. We identify 8 of them as stars (but some or all could have binary companions), and use information from Gaia to report distances and X-ray luminositiesmore » for 3 of them. There are 4 CVs or CV candidates, and we argue that NuSTAR J233426–2343.9 is a relatively strong CV candidate based partly on an X-ray spectrum from XMM-Newton . NuSTAR J092418–3142.2, which is the brightest serendipitous source in the Lansbury catalog, and NuSTAR J073959–3147.8 are low-mass X-ray binary candidates, but it is also possible that these 2 sources are CVs. One of the sources is a known high-mass X-ray binary (HMXB), and NuSTAR J105008–5958.8 is a new HMXB candidate that has strong Balmer emission lines in its optical spectrum and a hard X-ray spectrum. We discuss the implications of finding these HMXBs for the surface density (log N –log S ) and luminosity function of Galactic HMXBs. We conclude that with the large fraction of unclassified sources in the Galactic plane detected by NuSTAR in the 8–24 keV band, there could be a significant population of low-luminosity HMXBs.« less

Calculating Path-Dependent Travel Time Prediction Variance and Covariance for the SALSA3D Global Tomographic P-Velocity Model with a Distributed Parallel Multi-Core Computer

NASA Astrophysics Data System (ADS)

Hipp, J. R.; Encarnacao, A.; Ballard, S.; Young, C. J.; Phillips, W. S.; Begnaud, M. L.

2011-12-01

Recently our combined SNL-LANL research team has succeeded in developing a global, seamless 3D tomographic P-velocity model (SALSA3D) that provides superior first P travel time predictions at both regional and teleseismic distances. However, given the variable data quality and uneven data sampling associated with this type of model, it is essential that there be a means to calculate high-quality estimates of the path-dependent variance and covariance associated with the predicted travel times of ray paths through the model. In this paper, we show a methodology for accomplishing this by exploiting the full model covariance matrix. Our model has on the order of 1/2 million nodes, so the challenge in calculating the covariance matrix is formidable: 0.9 TB storage for 1/2 of a symmetric matrix, necessitating an Out-Of-Core (OOC) blocked matrix solution technique. With our approach the tomography matrix (G which includes Tikhonov regularization terms) is multiplied by its transpose (GTG) and written in a blocked sub-matrix fashion. We employ a distributed parallel solution paradigm that solves for (GTG)-1 by assigning blocks to individual processing nodes for matrix decomposition update and scaling operations. We first find the Cholesky decomposition of GTG which is subsequently inverted. Next, we employ OOC matrix multiply methods to calculate the model covariance matrix from (GTG)-1 and an assumed data covariance matrix. Given the model covariance matrix we solve for the travel-time covariance associated with arbitrary ray-paths by integrating the model covariance along both ray paths. Setting the paths equal gives variance for that path. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buchanan, Charles D.; Cline, David B.; Byers, N.

Progress in the various components of the UCLA High-Energy Physics Research program is summarized, including some representative figures and lists of resulting presentations and published papers. Principal efforts were directed at the following: (I) UCLA hadronization model, PEP4/9 e{sup +}e{sup {minus}} analysis, {bar P} decay; (II) ICARUS and astroparticle physics (physics goals, technical progress on electronics, data acquisition, and detector performance, long baseline neutrino beam from CERN to the Gran Sasso and ICARUS, future ICARUS program, and WIMP experiment with xenon), B physics with hadron beams and colliders, high-energy collider physics, and the {phi} factory project; (III) theoretical high-energy physics;more » (IV) H dibaryon search, search for K{sub L}{sup 0} {yields} {pi}{sup 0}{gamma}{gamma} and {pi}{sup 0}{nu}{bar {nu}}, and detector design and construction for the FNAL-KTeV project; (V) UCLA participation in the experiment CDF at Fermilab; and (VI) VLPC/scintillating fiber R D.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Progress in the various components of the UCLA High-Energy Physics Research program is summarized, including some representative figures and lists of resulting presentations and published papers. Principal efforts were directed at the following: (I) UCLA hadronization model, PEP4/9 e{sup +}e{sup {minus}} analysis, {bar P} decay; (II) ICARUS and astroparticle physics (physics goals, technical progress on electronics, data acquisition, and detector performance, long baseline neutrino beam from CERN to the Gran Sasso and ICARUS, future ICARUS program, and WIMP experiment with xenon), B physics with hadron beams and colliders, high-energy collider physics, and the {phi} factory project; (III) theoretical high-energy physics;more » (IV) H dibaryon search, search for K{sub L}{sup 0} {yields} {pi}{sup 0}{gamma}{gamma} and {pi}{sup 0}{nu}{bar {nu}}, and detector design and construction for the FNAL-KTeV project; (V) UCLA participation in the experiment CDF at Fermilab; and (VI) VLPC/scintillating fiber R & D.« less

Soluble copper phthalocyanine applied for organic solar cells.

PubMed

Zhang, Tianhui; Piao, Lingyu; Zha, Suling; Jiang, Chao; Xu, Zheng; Gao, Liyan; Wu, Qian; Kong, Chao

2011-11-01

A soluble derivative of copper phthalocyanine, that is 2,9,16,23-tetra carboxyl copper phthalocyanine (CuTCPc), is synthesized in this paper. The applications of CuTCPc as donor and interlayer materials in solar cell devices are investigated. The results demonstrate that when CuTCPc is used as a donor material, the performance of the device ITO/CuTCPc/PCBM/Al shows an open circuit voltage (V(OC)) of 0.54 V, a short circuit current (J(SC)) of 0.825 mA/cm2, a fill factor (FF) of 32.3% and the power conversion efficiency (nu) of 0.14%. When CuTCPc acts as an interlayer, the performance of the device ITO/CuTCPc/P3HT:PCBM/Al is improved: J(SC) increases to 3.12 mA/cm2, V(OC) increases to 0.59 V, FF increases to 33.8%, and the corresponding nu is 0.62%.

First measurement of the ratio of branching fractions B({lambda}{sub b}{sup 0}{yields}{lambda}{sub c}{sup +}{mu}{sup -}{nu}{sub {mu}})/B({lambda}{sub b}{sup 0}{yields}{lambda}{sub c}{sup +}{pi}{sup -})

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaltonen, T.; Maki, T.; Mehtala, P.

2009-02-01

This article presents the first measurement of the ratio of branching fractions B({lambda}{sub b}{sup 0}{yields}{lambda}{sub c}{sup +}{mu}{sup -}{nu}{sub {mu}})/B({lambda}{sub b}{sup 0}{yields}{lambda}{sub c}{sup +}{pi}{sup -}). Measurements in two control samples using the same technique B(B{sup 0}{yields}D{sup +}{mu}{sup -}{nu}{sub {mu}})/B(B{sup 0}{yields}D{sup +}{pi}{sup -}) and B(B{sup 0}{yields}D*(2010){sup +}{mu}{sup -}{nu}{sub {mu}})/B(B{sup 0}{yields}D*(2010){sup +}{pi}{sup -}) are also reported. The analysis uses data from an integrated luminosity of approximately 172 pb{sup -1} of pp collisions at {radical}(s)=1.96 TeV, collected with the CDF II detector at the Fermilab Tevatron. The relative branching fractions are measured to be (B({lambda}{sub b}{sup 0}{yields}{lambda}{sub c}{sup +}{mu}{sup -}{nu}{sub {mu}})/B({lambda}{sub b}{sup 0}{yields}{lambda}{sub c}{supmore » +}{pi}{sup -}))=16.6{+-}3.0(stat){+-}1.0(syst)(+2.6/-3.4)(PDG){+-}0.3 (EBR), (B(B{sup 0}{yields}D{sup +}{mu}{sup -}{nu}{sub {mu}})/B(B{sup 0}{yields}D{sup +}{pi}{sup -}))9.9{+-}1.0(stat){+-}0.6(syst){+-}0.4(PDG){+-}0.5(EBR), and (B(B{sup 0}{yields}D*(2010){sup +}{mu}{sup -}{nu}{sub {mu}})/B(B{sup 0}{yields}D*(2010){sup +}{pi}{sup -}))=16.5{+-}2.3(stat){+-} 0.6(syst){+-}0.5(PDG){+-}0.8(EBR). The uncertainties are from statistics (stat), internal systematics (syst), world averages of measurements published by the Particle Data Group or subsidiary measurements in this analysis (PDG), and unmeasured branching fractions estimated from theory (EBR), respectively. This article also presents measurements of the branching fractions of four new {lambda}{sub b}{sup 0} semileptonic decays: {lambda}{sub b}{sup 0}{yields}{lambda}{sub c}(2595){sup +}{mu}{sup -}{nu}{sub {mu}}, {lambda}{sub b}{sup 0}{yields}{lambda}{sub c}(2625){sup +}{mu}{sup -}{nu}{sub {mu}}, {lambda}{sub b}{sup 0}{yields}{sigma}{sub c}(2455){sup 0}{pi}{sup +}{mu}{sup -}{nu}{sub {mu}}, and {lambda}{sub b}{sup 0}{yields}{sigma}{sub c}(2455){sup ++}{pi}{sup -}{mu}{sup -}{nu}{sub {mu}}, relative to the branching fraction of the {lambda}{sub b}{sup 0}{yields}{lambda}{sub c}{sup +}{mu}{sup -}{nu}{sub {mu}} decay. Finally, the transverse-momentum distribution of {lambda}{sub b}{sup 0} baryons produced in pp collisions is measured and found to be significantly different from that of B{sup 0} mesons, which results in a modification in the production cross-section ratio {sigma}{sub {lambda}{sub b}{sup 0}}/{sigma}{sub B{sup 0}} with respect to the CDF I measurement.« less

pO{sub 2} Fluctuation Pattern and Cycling Hypoxia in Human Cervical Carcinoma and Melanoma Xenografts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ellingsen, Christine; Ovrebo, Kirsti Marie; Galappathi, Kanthi

2012-07-15

Purpose: Blood perfusion in tumors is spatially and temporally heterogeneous, resulting in local fluctuations in tissue oxygen tension (pO{sub 2}) and tissue regions showing cycling hypoxia. In this study, we investigated whether the pO{sub 2} fluctuation pattern and the extent of cycling hypoxia differ between tumor types showing high (e.g., cervical carcinoma xenograft) and low (e.g., melanoma xenograft) fractions of connective tissue-associated blood vessels. Methods and Materials: Two cervical carcinoma lines (CK-160 and TS-415) and two melanoma lines (A-07 and R-18) transplanted into BALB/c nu/nu mice were included in the study. Tissue pO{sub 2} was measured simultaneously in two positionsmore » in each tumor by using a two-channel OxyLite fiber-optic oxygen-sensing device. The extent of acute and chronic hypoxia was assessed by combining a radiobiological and a pimonidazole-based immunohistochemical assay of tumor hypoxia. Results: The proportion of tumor regions showing pO{sub 2} fluctuations, the pO{sub 2} fluctuation frequency in these regions, and the relative amplitude of the pO{sub 2} fluctuations were significantly higher in the melanoma xenografts than in the cervical carcinoma xenografts. Cervical carcinoma and melanoma xenografts did not differ significantly in the fraction of acutely hypoxic cells or the fraction of chronically hypoxic cells. However, the ratio between fraction of acutely hypoxic cells and fraction of chronically hypoxic cells was significantly higher in melanoma than in cervical carcinoma xenografts. Conclusions: Temporal heterogeneity in blood flow and tissue pO{sub 2} in tumors may depend on tumor histology. Connective tissue surrounding microvessels may stabilize blood flow and pO{sub 2} and, thus, protect tumor tissue from cycling hypoxia.« less

Cosmological neutrino simulations at extreme scale

DOE PAGES

Emberson, J. D.; Yu, Hao-Ran; Inman, Derek; ...

2017-08-01

Constraining neutrino mass remains an elusive challenge in modern physics. Precision measurements are expected from several upcoming cosmological probes of large-scale structure. Achieving this goal relies on an equal level of precision from theoretical predictions of neutrino clustering. Numerical simulations of the non-linear evolution of cold dark matter and neutrinos play a pivotal role in this process. We incorporate neutrinos into the cosmological N-body code CUBEP3M and discuss the challenges associated with pushing to the extreme scales demanded by the neutrino problem. We highlight code optimizations made to exploit modern high performance computing architectures and present a novel method ofmore » data compression that reduces the phase-space particle footprint from 24 bytes in single precision to roughly 9 bytes. We scale the neutrino problem to the Tianhe-2 supercomputer and provide details of our production run, named TianNu, which uses 86% of the machine (13,824 compute nodes). With a total of 2.97 trillion particles, TianNu is currently the world’s largest cosmological N-body simulation and improves upon previous neutrino simulations by two orders of magnitude in scale. We finish with a discussion of the unanticipated computational challenges that were encountered during the TianNu runtime.« less

XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans.

PubMed

Cardoso, Carlos; Couillault, Carole; Mignon-Ravix, Cecile; Millet, Anne; Ewbank, Jonathan J; Fontés, Michel; Pujol, Nathalie

2005-02-01

Mutations in the XNP/ATR-X gene cause several X-linked mental retardation syndromes in humans. The XNP/ATR-X gene encodes a DNA-helicase belonging to the SNF2 family. It has been proposed that XNP/ATR-X might be involved in chromatin remodelling. The lack of a mouse model for the ATR-X syndrome has, however, hampered functional studies of XNP/ATR-X. C. elegans possesses one homolog of the XNP/ATR-X gene, named xnp-1. By analysing a deletion mutant, we show that xnp-1 is required for the development of the embryo and the somatic gonad. Moreover, we show that abrogation of xnp-1 function in combination with inactivation of genes of the NuRD complex, as well as lin-35/Rb and hpl-2/HP1 leads to a stereotyped block of larval development with a cessation of growth but not of cell division. We also demonstrate a specific function for xnp-1 together with lin-35 or hpl-2 in the control of transgene expression, a process known to be dependent on chromatin remodelling. This study thus demonstrates that in vivo XNP-1 acts in association with RB, HP1 and the NuRD complex during development.

Recent Chandra/HETGS and NuSTAR observations of the quasar PDS 456 and its Ultra-Fast Outflow

NASA Astrophysics Data System (ADS)

Boissay Malaquin, Rozenn; Marshall, Herman L.; Nowak, Michael A.

2018-01-01

Evidence is growing that the interaction between outflows from active galactic nuclei (AGN) and their surrounding medium may play an important role in galaxy evolution, i.e. in the regulation of star formation in galaxies, through AGN feedback processes. Indeed, powerful outflows, such as the ultra-fast outflows (UFOs) that can reach mildly relativistic velocities of 0.2-0.4c, could blow away a galaxy’s reservoir of star-forming gas and hence quench the star formation in host galaxies. The low-redshift (z=0.184) radio-quiet quasar PDS 456 has showed the presence of a strong and blueshifted absorption trough in the Fe K band above 7 keV, that has been associated with the signature of such a fast and highly ionized accretion disk wind of a velocity of 0.25-0.3c. This persistent and variable feature has been detected in many observations of PDS 456, in particular by XMM-Newton, Suzaku and NuSTAR, together with other blueshifted absorption lines in the soft energy band (e.g. Nardini et al. 2015, Reeves et al. 2016). I will present here the results of the analysis of recent and contemporaneous high-resolution Chandra/HETGS and NuSTAR observations of PDS 456, and compare them with the previous findings.

Structural studies and molecular dynamics simulations suggest a processive mechanism of exolytic lytic transglycosylase from Campylobacter jejuni.

PubMed

Vijayaraghavan, Jagamya; Kumar, Vijay; Krishnan, Nikhil P; Kaufhold, Ross T; Zeng, Ximin; Lin, Jun; van den Akker, Focco

2018-01-01

The bacterial soluble lytic transglycosylase (LT) breaks down the peptidoglycan (PG) layer during processes such as cell division. We present here crystal structures of the soluble LT Cj0843 from Campylobacter jejuni with and without bulgecin A inhibitor in the active site. Cj0843 has a doughnut shape similar but not identical to that of E. coli SLT70. The C-terminal catalytic domain is preceded by an L-domain, a large helical U-domain, a flexible linker, and a small N-terminal NU-domain. The flexible linker allows the NU-domain to reach over and complete the circular shape, using residues conserved in the Epsilonproteobacteria LT family. The inner surface of the Cj0843 doughnut is mostly positively charged including a pocket that has 8 Arg/Lys residues. Molecular dynamics simulations with PG strands revealed a potential functional role for this pocket in anchoring the negatively charged terminal tetrapeptide of the PG during several steps in the reaction including homing and aligning the PG strand for exolytic cleavage, and subsequent ratcheting of the PG strand to enhance processivity in degrading PG strands.

KSC-2012-1150

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, preparations are under way to remove the environmentally controlled shipping container from around NASA's Nuclear Spectroscopic Telescope Array (NuSTAR). The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1162

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, workers position a lifting fixture toward NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) during preparations to hoist it from its shipping container. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1151

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, a crane is connected to the environmentally controlled shipping container during preparations to lift it away from NASA's Nuclear Spectroscopic Telescope Array (NuSTAR). The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1156

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, the top half of the shipping container is lifted away from NASA's Nuclear Spectroscopic Telescope Array (NuSTAR), wrapped in a protective shroud. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1158

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, workers prepare to remove the protective shroud from around NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) as it rests in the bottom half of a shipping container. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1165

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, a lifting fixture is employed to hoist NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) from its shipping container. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1163

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, workers attach a lifting fixture to NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) during preparations to hoist it from its shipping container. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1152

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, a crane lifts half of the environmentally controlled shipping container, providing a glimpse of NASA's Nuclear Spectroscopic Telescope Array (NuSTAR). The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1159

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, workers start to remove the protective shroud from around NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) as it rests in the bottom half of a shipping container. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1161

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, workers remove the protective shroud from around NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) as it rests in the bottom half of a shipping container. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1153

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, the environmentally controlled shipping container is lifted from around NASA's Nuclear Spectroscopic Telescope Array (NuSTAR), wrapped in a protective shroud. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1167

NASA Image and Video Library

2012-01-28

VANDENBERG AIR FORCE BASE, Calif. -- In the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California, workers prepare a handling dolly to receive NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) as it glides away from its shipping container. The spacecraft arrived at VAFB Jan. 27 after a cross-country trip which began from Orbital Sciences' manufacturing plant in Dulles, Va., on Jan. 24. Next, NuSTAR will be transferred from the airlock into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After checkout and other processing activities are complete, the spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. The rocket and spacecraft then will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy X-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

Calibration and Compensation of Instrumental Errors in Imaging Polarimeters

DTIC Science & Technology

2007-04-01

procedures for polarimeters 3. Examine impact of focal plane nonuniformity on polarimeters 4. Understand the role of bandwidth in broadband polarimetry. 5... nonuniformity (NU) noise. NU noise is a results from pixel-to-pixel variations in the photodetector response. NU noise is a persistent problem for all... nonuniformity noise in imaging polarimeters," Proc SPIE Vol. 5888: Polarization Science and Remote Sensing 11, pp. 58880J 1 - 10, J. A. Shaw and J. S

Measurement of the decay constant f(Ds+) using D(s+)-->l+ nu.

PubMed

Artuso, M; Blusk, S; Butt, J; Khalil, S; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Naik, P; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Ecklund, K M; Severini, H; Love, W; Savinov, V; Aquines, O; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F

2007-08-17

We measure the decay constant f(Ds+) using the D(s+)-->l+ nu channel, where the l+ designates either a mu+ or a tau+, when the tau+ -->pi+ nu. Using both measurements we find f(Ds+)=274+/-13+/-7 MeV. Combining with our previous determination of f(D+), we compute the ratio f(Ds+)/f(D+)=1.23+/-0.11+/-0.04. We compare with theoretical estimates.

CF.sub.4 laser

DOEpatents

Wittig, Curt; Tiee, Joe J.

1979-01-01

A CF.sub.4 laser for producing near 16 .mu.m radiation utilizing a line tunable CO.sub.2 laser as an optical pumping source. The device uses a cryogenically cooled optically pumped cell containing molecular CF.sub.4 gas. An optical resonant cavity formed around the optically pumped cell induces oscillations of near 16 .mu.m radiation from the .nu..sub.2 +.nu..sub.4 .fwdarw..nu..sub.2 transition in the molecular CF.sub.4 gas.

Psychometric properties of Malay neuropsychiatry unit cognitive assessment tool among Alzheimer's disease patients in comparison to Malay Montreal Cognitive Assessment.

PubMed

Thong, Kai Shin; Chee, Kok Yoon; Ng, Chong Guan; Walterfang, Mark; Velakoulis, Dennis

2016-09-01

This study aims to establish psychometric properties of the Malay Neuropsychiatry Unit Cognitive Assessment Tool (Malay NuCOG) in Alzheimer's disease. NuCOG was translated to Malay language and compared with Montreal Cognitive Assessment Tool on 80 individuals. The Malay NuCOG showed good internal consistency and reliability (Cronbach's alpha = 0.895). It demonstrated 100% sensitivity and 87.5% specificity at the cutoff score of 78.50/100. The Malay NuCOG is a valid and reliable cognitive instrument that is sensitive and specific for the detection of dementia and has clinical advantages in its ability to examine individual cognitive domains. © 2015 Wiley Publishing Asia Pty Ltd.

Average size of random polygons with fixed knot topology.

PubMed

Matsuda, Hiroshi; Yao, Akihisa; Tsukahara, Hiroshi; Deguchi, Tetsuo; Furuta, Ko; Inami, Takeo

2003-07-01

We have evaluated by numerical simulation the average size R(K) of random polygons of fixed knot topology K=,3(1),3(1) musical sharp 4(1), and we have confirmed the scaling law R(2)(K) approximately N(2nu(K)) for the number N of polygonal nodes in a wide range; N=100-2200. The best fit gives 2nu(K) approximately 1.11-1.16 with good fitting curves in the whole range of N. The estimate of 2nu(K) is consistent with the exponent of self-avoiding polygons. In a limited range of N (N greater, similar 600), however, we have another fit with 2nu(K) approximately 1.01-1.07, which is close to the exponent of random polygons.

Study of exclusive charmless semileptonic B decays and |Vub|.

PubMed

Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; Athar, S B; Patel, R; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Ecklund, K M; Severini, H; Love, W; Savinov, V; Aquines, O; Li, Z; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L

2007-07-27

We study semileptonic B decay to the exclusive charmless states pi, rho/omega, eta, and eta;{'} using the 16 fb(-1) CLEO Upsilon(4S) data sample. We find B(B0-->pi-l+nu)=(1.37+/-0.15stat+/-0.11sys)x10(-4) and B(B0-->rho-l+nu)=(2.93+/-0.37stat+/-0.37sys)x10(-4) and find evidence for B+-->eta'l+nu, with B(B+-->eta'l+nu)=(2.66+/-0.80stat+/-0.56sys)x10(-4). From our B-->pilnu rate for q2>16 GeV2 and lattice QCD, we find |Vub|=(3.6+/0.4stat+/0.2syst-0.4thy+0.6)x10(-3) [corrected

A serach for moderate- and high-energy neturino emission correlated with gamma-ray bursts

NASA Technical Reports Server (NTRS)

Becker-Szendy, R.; Bratton, C. B.; Breault, J.; Casper, D.; Dye, S. T.; Gajewski, W.; Goldhaber, M.; Haines, T. J.; Halverson, P. G.; Kielczewska, D.

1995-01-01

A temporal correlation analysis between moderate- (60 Mev less than or equal to E(sub nu)greater than or equal to 2500 MeV) and high-energy (E(sub nu) greater than or equal to 2000 MeV) neutrino interactions consist of two types: the moderate-energy interactions that are contained within the volume of IMB-3 and the upward-going muons produced by high-energy nu(sub mu) interactions in the rock around the detector. No evidence is found for moderate- or high-energy neutrino emission from GRBs nor for any neutrino/neutrino correlation. The nonobservation of nu/GRB correlations allows upper limits to be placed on the neutrino flux associated with GRBs.

Next-to-leading order QCD corrections to W{sup +}W{sup +}jj and W{sup -}W{sup -}jj production via weak-boson fusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jaeger, B.; Oleari, C.; Zeppenfeld, D.

2009-08-01

We present a next-to-leading order QCD calculation for e{sup +}{nu}{sub e}{mu}{sup +}{nu}{sub {mu}}jj and e{sup -}{nu}{sub e}{mu}{sup -}{nu}{sub {mu}}jj production via weak-boson fusion at a hadron collider in the form of a fully flexible parton-level Monte Carlo program, which allows for the calculation of experimentally accessible observables within realistic selection cuts. The QCD corrections to the integrated cross sections are found to be modest, while the shapes of some kinematical distributions change appreciably compared to leading order. The residual scale uncertainties of the next-to-leading order results are at the few-percent level.

KSC-2012-1138

NASA Image and Video Library

2012-01-27

VANDENBERG AIR FORCE BASE, Calif. -- Workers position NASA's Nuclear Spectroscopic Telescope Array (NuSTAR), enclosed in an environmentally controlled shipping container, onto a payload transporter for transfer of the telescope into the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California. The spacecraft arrived at 7:52 a.m. PST after a cross-country trip from Orbital Sciences' manufacturing plant in Dulles, Va., which began Jan. 24. The spacecraft will be offloaded into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After NuSTAR is removed from its shipping container, checkout and other processing activity will begin. The spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. After processing is completed, the rocket and spacecraft will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

KSC-2012-1137

NASA Image and Video Library

2012-01-27

VANDENBERG AIR FORCE BASE, Calif. -- A forklift is enlisted to transfer NASA's Nuclear Spectroscopic Telescope Array (NuSTAR), enclosed in an environmentally controlled shipping container, from the tractor-trailer on which it arrived into the airlock of processing facility 1555 at Vandenberg Air Force Base (VAFB) in California. The spacecraft arrived at 7:52 a.m. PST after a cross-country trip from Orbital Sciences' manufacturing plant in Dulles, Va., which began Jan. 24. The spacecraft will be offloaded into the processing hangar, joining the Pegasus XL rocket that is set to carry it to space. After NuSTAR is removed from its shipping container, checkout and other processing activity will begin. The spacecraft will be integrated with the Pegasus in mid-February and encapsulation in the vehicle fairing will follow. After processing is completed, the rocket and spacecraft will be flown on Orbital's L-1011 carrier aircraft to the Ronald Reagan Ballistic Missile Defense Test Site at the Pacific Ocean's Kwajalein Atoll for launch in March. The high-energy x-ray telescope will conduct a census for black holes, map radioactive material in young supernovae remnants, and study the origins of cosmic rays and the extreme physics around collapsed stars. For more information, visit http://www.nasa.gov/nustar. Photo credit: NASA/Randy Beaudoin, VAFB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miftakov, V

The BABAR experiment at SLAC provides an opportunity for measurement of the Standard Model parameters describing CP violation. A method of measuring the CKM matrix element |V{sub cb}| using Inclusive Semileptonic B decays in events tagged by a fully reconstructed decay of one of the B mesons is presented here. This mode is considered to be one of the most powerful approaches due to its large branching fraction, simplicity of the theoretical description and very clean experimental signatures. Using fully reconstructed B mesons to flag B{bar B} event we were able to produce the spectrum and branching fraction for electronmore » momenta P{sub C.M.S.} > 0.5 GeV/c. Extrapolation to the lower momenta has been carried out with Heavy Quark Effective Theory. The branching fractions are measured separately for charged and neutral B mesons. For 82 fb{sup -1} of data collected at BABAR we obtain: BR(B{sup {+-}} {yields} X e{bar {nu}}) = 10.63 {+-} 0.24 {+-} 0.29%, BR(B{sup 0} {yields} X e{bar {nu}}) = 10.68 {+-} 0.34 {+-} 0.31%, averaged BR(B {yields} X e{bar {nu}}) = 10.65 {+-} 0.19 {+-} 0.27%, ratio of Branching fractions BR(B{sup {+-}})/BR(B{sup 0}) = 0.996 {+-} 0.039 {+-} 0.015 (errors are statistical and systematic, respectively). They also obtain V{sub cb} = 0.0409 {+-} 0.00074 {+-} 0.0010 {+-} 0.000858 (errors are: statistical, systematic and theoretical).« less

Living in the Here and Now: Interrelationships between Impulsivity, Mindfulness, and Alcohol Misuse

PubMed Central

Murphy, Cara; MacKillop, James

2013-01-01

Rationale Impulsivity and mindfulness both emphasize orientation to the present, and both have been linked to alcohol misuse, but the relationship between the two is not clearly understood. Objectives To examine the relationships between elements of impulsivity and mindfulness, and to examine both variables in relation to alcohol misuse. Method Young adults (N = 116) were assessed for alcohol use, mindfulness, and impulsivity using psychometrically validated measures. Results Numerous significant associations were present among the facets of impulsivity and mindfulness. The variable most substantially associated with alcohol misuse was Negative Urgency (NU; i.e., proneness to act out under conditions of negative affect). After controlling for other variables, Negative Urgency (NU), Positive Urgency (PU), and delay discounting (DD) were significantly related to alcohol consumption. When examining drinking related consequences, only Lack of Premeditation (LoP) and Negative Urgency (NU) were significant associated. Conclusions There was considerable overlap between some elements of impulsivity and mindfulness while the overlap was negligible for other facets. The associations between mindfulness and alcohol misuse were entirely a function of impulsivity. In particular, acting on impulses while experiencing negative affect was significantly associated with level of alcohol consumption and level of alcohol-related risk. Steep discounting of future rewards was associated with alcohol consumption while poor premeditation was associated with adverse drinking consequences. These findings illustrate the importance of jointly studying impulsivity when examining purported effects of mindfulness traits. PMID:22169883

Materials Properties Data Management--Approaches to a Critical National Need

DTIC Science & Technology

1983-09-01

President. Research & l)cvcloprn:nuDirector. Lexington Laboratory Air Products & Chemical%. IncThe Kendall Co. Dr. Alan Lawlev P.O. Box 538Lexington...of DelawareEngineering & Research Staff Newark, DE 19"! !1• Frd Motor Co. K M. Zwilsky. txcumie Daek:ior P.O. kx 2053 Dearborn. MI 4h 121 W.. X" 5/M...UNCLASSIFIED SECURITY CLASSIFICATION OF TNIS PAGE (When Dole EnElo4 -, UNCLASSIFIED UiCUNTIV CLASSIFICATION OF THIS PA6E(Uhm b0 filo generates the major

Master equation for a kinetic model of a trading market and its analytic solution.

PubMed

Chatterjee, Arnab; Chakrabarti, Bikas K; Stinchcombe, Robin B

2005-08-01

We analyze an ideal-gas-like model of a trading market with quenched random saving factors for its agents and show that the steady state income (m) distribution P(m) in the model has a power law tail with Pareto index nu exactly equal to unity, confirming the earlier numerical studies on this model. The analysis starts with the development of a master equation for the time development of P(m) . Precise solutions are then obtained in some special cases.

Density functional calculations on the effect of sulfur substitution for 2'-hydroxypropyl-p-nitrophenyl phosphate: C-O vs. P-O bond cleavage.

PubMed

Xia, Futing; Zhu, Hua

2012-02-01

Density functional theory calculations have been used to investigate the intra-molecular attack of 2'-hydroxypropyl-p-nitrophenyl phosphate (HPpNP) and its analogous compound 2-thiouridyl-p-nitrophenyl phosphate (s-2'pNP). Bulk solvent effect has been tested at the geometry optimization level with the polarized continuum model. It is found that the P-path involving the intra-molecular attack at the phosphorus atom and C-path involving the attack at the beta carbon atom proceed through the S(N)2-type mechanism for HPpNP and s-2'pNP. The calculated results indicate that the P-path with the free energy barrier of about 11 kcal/mol is more accessible than the C-path for the intra-molecular attack of HPpNP, which favors the formation of the five-membered phosphate diester. While for s-2'pNP, the C-path with the free energy barrier of about 21 kcal/mol proceeds more favorably than the P-path. The calculated energy barriers of the favorable pathways for HPpNP and s-2'pNP are both in agreement with the experimental results. Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved.

Fully quantum-state resolved study of NO{sub 2} photodissociation. Correlated NO({sup 2}{Pi}{sub {Omega}}, {nu} = 0 J,A) + O({sup 3}P{sub j}) distributions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanov, A.; Bieler, C.R.; Reisler, H.

1995-09-14

Relative O({sup 3}P{sub j} = 2.1.0) spin-orbit populations correlated with specific NO[{sup 2}{Pi}{sub {Omega}} = {1/2}, 3/2; {nu} = 0; f; {Lambda} = {Pi}(A{prime}), {Pi}(A{double_prime})] product states were obtained following photolysis of NO{sub 2} at excess energies E{sup {+-}} = 390, 425, and 1054 cm{sup -1}. These fully quantum state-resolved measurements were carried out by recording spatial profiles of recoiling NO({sup 2}{Pi}{sub {Omega}}, J, {Lambda}) products using polarized radiation for photolysis and state-selective laser ionization detection. The relative O({sup 3}P{sub j}) populations correlated with each NO({sup 2}{Pi}{sub {Omega}}, J, {Lambda}) state show marked fluctuations at each excess energy as amore » function of rotational state and {Lambda}-doublet component. The relative populations also fluctuate as a function of excess energy. The O({sup 3}P{sub j}) spin-orbit population ratios, when averaged over all measurements, exhibit distributions that are colder than statistical, in agreement with previous results. In particular, we find that, on average, O({sup 3}P{sub 1}):O({sup 3}P{sub 2}) population ratios correlated with the ground NO({sup 2}{Pi}{sub {1/2}}) state are colder than the corresponding ratios correlated with the excited NO({sup 2}{Pi}{sub 3/2}) spin-orbit state. These results are in agreement with the state-specific calculations of Katigiri and Kato. 45 refs., 12 figs., 3 tabs.« less

NuSTAR results from the Galactic Center - diffuse emission

NASA Astrophysics Data System (ADS)

Hailey, Charles

2016-03-01

The Nuclear Spectroscopic Telescope Array (NuSTAR) was launched in June 2012. It carried the first true, hard X-ray (>~10 keV-79 keV) focusing telescopes into orbit. Its twin telescopes provide 10 times better angular resolution and 100 times better sensitivity than previously obtainable in the hard X-ray band. Consequently NuSTAR is able to resolve faint diffuse structures whose hard X-rays offer insight into some of the most energetic processes in the Galactic Center. One of the surprising discoveries that NuSTAR made in the Galactic Center is the central hard X-ray emission (CHXE). The CHXE is a diffuse emission detected from ~10 keV to beyond 50 keV in X-ray energy, and extending spatially over a region ~8 parsecs x ~4 parsecs in and out of the plane of the galaxy respectively, and centered on the supermassive black hole Sgr A*. The CHXE was speculated to be due to a large population of unresolved black hole X-ray binaries, millisecond pulsars (MSP), a class of highly magnetized white dwarf binaries called intermediate polars, or to particle outflows from Sgr A*. The presence of an unexpectedly large population of MSP in the Galactic Center would be particularly interesting, since MSP emitting at higher energies and over a much larger region have been posited to be the origin of the gamma-ray emission that is also ascribed to dark matter annihilation in the galaxy. In addition, the connection of the CHXE to the ~9000 unidentified X-ray sources in the central the the ~100 pc detected by the Chandra Observatory, to the soft X-ray emission detected by the Chandra and XMM/Newton observatories in the Galactic Center, and to the hard X-ray emission detected by both the RXTE and INTEGRAL observatories in the Galactic Ridge, is unclear. I review these results and present recent NuSTAR observations that potentially resolve the origin of the CHXE and point to a unified origin for all these X-ray emissions. Two other noteworthy classes of diffuse structures in the Galactic Center will be discussed. The first class are the giant molecular clouds, which are strong hard X-ray emitters. These hard X-rays are believed to be produced when one or more giant outbursts from the supermassive black hole Sgr A*, more than a century ago, resulted in hard X-rays being reflected from the clouds, and detected only today. I discuss how these hard X-rays are used to elucidate the past history of the supermassive black hole, and to compare and contrast these past giant outbursts with those observed from the supermassive black hole more recently. The second class are non-thermal filaments, magnetized structures with both radio and soft X-ray emission that have now been shown by NuSTAR to be hard X-ray emitters. The electrons generating the hard X-rays observed in one of these filaments are the most energetic that have been observed in the galaxy. The filaments are a heterogeneous class of hard X-ray emitters, and the various mechanisms by which they produce hard X-ray emission will be discussed. Future NuSTAR observations of the Galactic Center with NuSTAR will also be discussed.

Pregnancy as a Window to Future Cardiovascular Health: Design and Implementation of the nuMoM2b Heart Health Study

PubMed Central

Haas, David M; Ehrenthal, Deborah B; Koch, Matthew A; Catov, Janet M; Barnes, Shannon E; Facco, Francesca; Parker, Corette B; Mercer, Brian M; Bairey-Merz, C Noel; Silver, Robert M; Wapner, Ronald J; Simhan, Hyagriv N; Hoffman, Matthew K; Grobman, William A; Greenland, Philip; Wing, Deborah A; Saade, George R; Parry, Samuel; Zee, Phyllis C; Reddy, Uma M; Pemberton, Victoria L; Burwen, Dale R

2016-01-01

Abstract The National Institute of Child Health and Human Development's Nulliparous Pregnancy Outcomes Study-Monitoring Mothers-to-Be (nuMoM2b) Heart Health Study (HHS) was designed to investigate the relationships between adverse pregnancy outcomes and modifiable risk factors for cardiovascular disease. The ongoing nuMoM2b-HHS, which started in 2013, is a prospective follow-up of the nuMoM2b cohort, which included 10,038 women recruited between 2010 and 2013 from 8 centers across the United States who were initially observed over the course of their first pregnancies. In this report, we detail the design and study procedures of the nuMoM2b-HHS. Women in the pregnancy cohort who consented to be contacted for participation in future studies were approached at 6-month intervals to ascertain health information and to maintain ongoing contact. Two to 5 years after completion of the pregnancy documented in the nuMoM2b, women in the nuMoM2b-HHS were invited to an in-person study visit. During this visit, they completed psychosocial and medical history questionnaires and had clinical measurements and biological specimens obtained. A subcohort of participants who had objective assessments of sleep-disordered breathing during pregnancy were asked to repeat this investigation. This unique prospective observational study includes a large, geographically and ethnically diverse cohort, rich depth of phenotypic information about adverse pregnancy outcomes, and clinical data and biospecimens from early in the index pregnancy onward. Data obtained from this cohort will provide mechanistic and clinical insights into how data on a first pregnancy can provide information about the potential development of subsequent risk factors for cardiovascular disease. PMID:26825925

Pan-antimicrobial failure of alexidine as a contact lens disinfectant when heated in Bausch & Lomb plastic containers: implications for the worldwide Fusarium keratitis epidemic of 2004 to 2006.

PubMed

Elder, B Laurel; Bullock, John D; Warwar, Ronald E; Khamis, Harry J; Khalaf, Shaden Z

2012-07-01

ReNu with MoistureLoc (ReNuML), containing the antimicrobial agent alexidine 0.00045%, was associated with the Fusarium keratitis epidemic of 2004 to 2006. Although a single-point source contamination was ruled out, only Fusarium organisms were reported during the outbreak. This study investigated whether the reported loss of antimicrobial effectiveness toward Fusarium of ReNuML after exposure to heat in high-density polyethylene (HDPE) plastic containers could also be demonstrated with other common fungal and bacterial agents of keratitis. A buffered solution of alexidine 0.00045% was incubated in glass and ReNu HDPE plastic containers at room temperature (RT) and 56°C for 4 weeks, serially diluted, and tested for its ability to inhibit the growth of 20 bacterial isolates, 12 non-Fusarium fungal isolates, and 7 Fusarium isolates originally involved in the keratitis epidemic. A statistically significant loss of antimicrobial capability was seen with all fungi, all gram-positive bacteria, and all isolates of Klebsiella when alexidine 0.00045% was incubated at 56°C in ReNu HDPE containers compared with RT or glass incubation (P≤0.0001). Heating of an alexidine solution in ReNu HDPE plastic (but not glass) containers results in the same loss of anti-Fusarium activity as reported when testing the original ReNuML solution. This loss of inhibitory activity is not specific to Fusarium and occurs with other fungi and bacteria that cause keratitis. The reasons for the lack of reports of bacterial and/or non-Fusarium fungal keratitis during the original Fusarium keratitis epidemic remain unclear at this time.

The NuSTAR View of the Non-Thermal Emission from PSR J0437-4715

NASA Technical Reports Server (NTRS)

Guillot, S.; Kaspi, V. M.; Archibald, R. F.; Bachetti, M.; Flynn, C.; Jankowski, F.; Bailes, M.; Boggs, S.; Christensen, F. E.; Craig, W. W.;

The NuSTAR Education and Public Outreach Program

NASA Astrophysics Data System (ADS)

Cominsky, Lynn R.; McLin, K. M.; NuSTAR Team

2010-01-01

The Nuclear Spectroscopic Telescope Array (NuSTAR) is a NASA Small Explorer mission led by Caltech, managed by JPL, and implemented by an international team of scientists and engineers, under the direction of CalTech Professor Fiona Harrison, principal investigator. NuSTAR is a pathfinder mission that will open the high-energy X-ray sky for sensitive study for the first time. By focusing X-rays at higher energies (up to 79 keV) NuSTAR will answer fundamental questions about the Universe: How are black holes distributed through the cosmos? How were the elements that compose our bodies and the Earth forged in the explosions of massive stars? What powers the most extreme active galaxies? Perhaps most exciting is the opportunity to fill a blank map with wonders we have not yet dreamed of: NuSTAR offers the opportunity to explore our Universe in an entirely new way. The purpose of the NuSTAR E/PO program is to increase student and public understanding of the science of the high-energy Universe, by capitalizing on the synergy of existing high-energy astrophysics E/PO programs to support the mission's objectives. Our goals are to: facilitate understanding of the nature of collapsed objects, develop awareness of the role of supernovae in creating the chemical elements and to facilitate understanding of the physical properties of the extreme Universe. We will do this through a program that includes educator workshops through NASA's Astrophysics Educator Ambassador program, by writing articles for Physics Teacher and Science Scope magazines to reach a broader community of educators, and by working with informal educators through museums and planetaria to develop an exhibit that includes a model of NuSTAR and describes the mission's science objectives. We will also develop printed materials such as a mission factsheet that describes the mission.

The NuSTAR Education and Public Outreach Program

NASA Astrophysics Data System (ADS)

Cominsky, Lynn R.; McLin, K. M.; NuSTAR Team

2010-03-01

NuSTAR is a NASA Small Explorer mission led by Caltech, managed by JPL, and implemented by an international team of scientists and engineers, under the direction of CalTech Professor Fiona Harrison, principal investigator. NuSTAR is a pathfinder mission that will open the high-energy X-ray sky for sensitive study for the first time. By focusing X-rays at higher energies (up to 79 keV) NuSTAR will answer fundamental questions about the Universe: How are black holes distributed through the cosmos? How were the elements that compose our bodies and the Earth forged in the explosions of massive stars? What powers the most extreme active galaxies? Perhaps most exciting is the opportunity to fill a blank map with wonders we have not yet dreamed of: NuSTAR offers the opportunity to explore our Universe in an entirely new way. The purpose of the NuSTAR E/PO program is to increase student and public understanding of the science of the high-energy Universe, by capitalizing on the synergy of existing high-energy astrophysics E/PO programs to support the mission's objectives. Our goals are to: facilitate understanding of the nature of collapsed objects, develop awareness of the role of supernovae in creating the chemical elements and to facilitate understanding of the physical properties of the extreme Universe. We will do this through a program that includes educator workshops through NASA's Astrophysics Educator Ambassador program, by writing articles for Physics Teacher and Science Scope magazines to reach a broader community of educators, and by working with informal educators through museums and planetaria to develop an exhibit that includes a model of NuSTAR and describes the mission's science objectives. We will also develop printed materials such as a mission factsheet that describes the mission.

Assessing the Fidelity of Ancient DNA Sequences Amplified From Nuclear Genes

PubMed Central

Binladen, Jonas; Wiuf, Carsten; Gilbert, M. Thomas P.; Bunce, Michael; Barnett, Ross; Larson, Greger; Greenwood, Alex D.; Haile, James; Ho, Simon Y. W.; Hansen, Anders J.; Willerslev, Eske

2006-01-01

To date, the field of ancient DNA has relied almost exclusively on mitochondrial DNA (mtDNA) sequences. However, a number of recent studies have reported the successful recovery of ancient nuclear DNA (nuDNA) sequences, thereby allowing the characterization of genetic loci directly involved in phenotypic traits of extinct taxa. It is well documented that postmortem damage in ancient mtDNA can lead to the generation of artifactual sequences. However, as yet no one has thoroughly investigated the damage spectrum in ancient nuDNA. By comparing clone sequences from 23 fossil specimens, recovered from environments ranging from permafrost to desert, we demonstrate the presence of miscoding lesion damage in both the mtDNA and nuDNA, resulting in insertion of erroneous bases during amplification. Interestingly, no significant differences in the frequency of miscoding lesion damage are recorded between mtDNA and nuDNA despite great differences in cellular copy numbers. For both mtDNA and nuDNA, we find significant positive correlations between total sequence heterogeneity and the rates of type 1 transitions (adenine → guanine and thymine → cytosine) and type 2 transitions (cytosine → thymine and guanine → adenine), respectively. Type 2 transitions are by far the most dominant and increase relative to those of type 1 with damage load. The results suggest that the deamination of cytosine (and 5-methyl cytosine) to uracil (and thymine) is the main cause of miscoding lesions in both ancient mtDNA and nuDNA sequences. We argue that the problems presented by postmortem damage, as well as problems with contamination from exogenous sources of conserved nuclear genes, allelic variation, and the reliance on single nucleotide polymorphisms, call for great caution in studies relying on ancient nuDNA sequences. PMID:16299392

Search for the rare leptonic decay B+-->mu(+)nu(mu).

PubMed

Aubert, B; Barate, R; Boutigny, D; Couderc, F; Gaillard, J-M; Hicheur, A; Karyotakis, Y; Lees, J P; Tisserand, V; Zghiche, A; Palano, A; Pompili, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; LeClerc, C; Levi, M E; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Shelkov, V G; Telnov, A V; Wenzel, W A; Ford, K; Harrison, T J; Hawkes, C M; Morgan, S E; Watson, A T; Watson, N K; Fritsch, M; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schmuecker, H; Steinke, M; Boyd, J T; Chevalier, N; Cottingham, W N; Kelly, M P; Latham, T E; Mackay, C; Wilson, F F; Abe, K; Cuhadar-Donszelmann, T; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Kyberd, P; McKemey, A K; Teodorescu, L; Blinov, V E; Bukin, A D; Golubev, V B; Ivanchenko, V N; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Yushkov, A N; Best, D; Bruinsma, M; Chao, M; Eschrich, I; Kirkby, D; Lankford, A J; Mandelkern, M; Mommsen, R K; Roethel, W; Stoker, D P; Buchanan, C; Hartfiel, B L; Gary, J W; Layter, J; Shen, B C; Wang, K; del Re, D; Hadavand, H K; Hill, E J; MacFarlane, D B; Paar, H P; Rahatlou, Sh; Sharma, V; Berryhill, J W; Campagnari, C; Dahmes, B; Levy, S L; Long, O; Lu, A; Mazur, M A; Richman, J D; Verkerke, W; Beck, T W; Beringer, J; Eisner, A M; Heusch, C A; Lockman, W S; Schalk, T; Schmitz, R E; Schumm, B A; Seiden, A; Spradlin, P; Walkowiak, W; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dubois-Felsmann, G P; Dvoretskii, A; Erwin, R J; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Yang, S; Jayatilleke, S; Mancinelli, G; Meadows, B T; Sokoloff, M D; Abe, T; Blanc, F; Bloom, P; Chen, S; Clark, P J; Ford, W T; Nauenberg, U; Olivas, A; Rankin, P; Roy, J; Smith, J G; van Hoek, W C; Zhang, L; Harton, J L; Hu, T; Soffer, A; Toki, W H; Wilson, R J; Zhang, J; Altenburg, D; Brandt, T; Brose, J; Colberg, T; Dickopp, M; Feltresi, E; Hauke, A; Lacker, H M; Maly, E; Müller-Pfefferkorn, R; Nogowski, R; Otto, S; Schubert, J; Schubert, K R; Schwierz, R; Spaan, B; Bernard, D; Bonneaud, G R; Brochard, F; Grenier, P; Thiebaux, Ch; Vasileiadis, G; Verderi, M; Bard, D J; Khan, A; Lavin, D; Muheim, F; Playfer, S; Andreotti, M; Azzolini, V; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Piemontese, L; Sarti, A; Treadwell, E; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Patteri, P; Piccolo, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Crosetti, G; Lo Vetere, M; Macri, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Bailey, S; Morii, M; Won, E; Dubitzky, R S; Langenegger, U; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Gaillard, J R; Morton, G W; Nash, J A; Taylor, G P; Grenier, G J; Lee, S-J; Mallik, U; Cochran, J; Crawley, H B; Lamsa, J; Meyer, W T; Prell, S; Rosenberg, E I; Yi, J; Davier, M; Grosdidier, G; Höcker, A; Laplace, S; Le Diberder, F; Lepeltier, V; Lutz, A M; Petersen, T C; Plaszczynski, S; Schune, M H; Tantot, L; Wormser, G; Brigljević, V; Cheng, C H; Lange, D J; Simani, M C; Wright, D M; Bevan, A J; Coleman, J P; Fry, J R; Gabathuler, E; Gamet, R; Kay, M; Parry, R J; Payne, D J; Sloane, R J; Touramanis, C; Back, J J; Harrison, P F; Mohanty, G B; Brown, C L; Cowan, G; Flack, R L; Flaecher, H U; George, S; Green, M G; Kurup, A; Marker, C E; McMahon, T R; Ricciardi, S; Salvatore, F; Vaitsas, G; Winter, M A; Brown, D; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Hart, P A; Hodgkinson, M C; Lafferty, G D; Lyon, A J; Williams, J C; Farbin, A; Hulsbergen, W D; Jawahery, A; Kovalskyi, D; Lae, C K; Lillard, V; Roberts, D A; Blaylock, G; Dallapiccola, C; Flood, K T; Hertzbach, S S; Kofler, R; Koptchev, V B; Moore, T B; Saremi, S; Staengle, H; Willocq, S; Cowan, R; Sciolla, G; Taylor, F; Yamamoto, R K; Mangeol, D J J; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Cote-Ahern, D; Taras, P; Nicholson, H; Cartaro, C; Cavallo, N; De Nardo, G; Fabozzi, F; Gatto, C; Lista, L; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; Wilden, L; Jessop, C P; LoSecco, J M; Gabriel, T A; Allmendinger, T; Brau, B; Gan, K K; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pulliam, T; Ter-Antonyan, R; Wong, Q K; Brau, J; Frey, R; Igonkina, O; Potter, C T; Sinev, N B; Strom, D; Torrence, E; Colecchia, F; Dorigo, A; Galeazzi, F; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Tiozzo, G; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; de la Vaissière, Ch; Del Buono, L; Hamon, O; John, M J J; Leruste, Ph; Ocariz, J; Pivk, M; Roos, L; T'Jampens, S; Therin, G; Manfredi, P F; Re, V; Behera, P K; Gladney, L; Guo, Q H; Panetta, J; Anulli, F; Biasini, M; Peruzzi, I M; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Bucci, F; Calderini, G; Carpinelli, M; Del Gamba, V; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Martinez-Vidal, F; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Walsh, J; Haire, M; Judd, D; Paick, K; Wagoner, D E; Danielson, N; Elmer, P; Lu, C; Miftakov, V; Olsen, J; Smith, A J S; Varnes, E W; Bellini, F; Cavoto, G; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Mazzoni, M A; Morganti, S; Pierini, M; Piredda, G; Safai Tehrani, F; Voena, C; Christ, S; Wagner, G; Waldi, R; Adye, T; De Groot, N; Franek, B; Geddes, N I; Gopal, G P; Olaiya, E O; Xella, S M; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Giraud, P-F; Hamel de Monchenault, G; Kozanecki, W; Langer, M; Legendre, M; London, G W; Mayer, B; Schott, G; Vasseur, G; Yeche, Ch; Zito, M; Purohit, M V; Weidemann, A W; Yumiceva, F X; Aston, D; Bartoldus, R; Berger, N; Boyarski, A M; Buchmueller, O L; Convery, M R; Cristinziani, M; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W; Elsen, E E; Field, R C; Glanzman, T; Gowdy, S J; Hadig, T; Halyo, V; Hryn'ova, T; Innes, W R; Kelsey, M H; Kim, P; Kocian, M L; Leith, D W G S; Libby, J; Luitz, S; Luth, V; Lynch, H L; Marsiske, H; Messner, R; Muller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Petrak, S; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Simi, G; Snyder, A; Soha, A; Stelzer, J; Su, D; Sullivan, M K; Va'vra, J; Wagner, S R; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wright, D H; Young, C C; Burchat, P R; Edwards, A J; Meyer, T I; Petersen, B A; Roat, C; Ahmed, M; Ahmed, S; Alam, M S; Ernst, J A; Saeed, M A; Saleem, M; Wappler, F R; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Kim, H; Ritchie, J L; Satpathy, A; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bona, M; Gallo, F; Gamba, D; Borean, C; Bosisio, L; Cossutti, F; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Poropat, P; Vitale, L; Vuagnin, G; Panvini, R S; Banerjee, Sw; Brown, C M; Fortin, D; Jackson, P D; Kowalewski, R; Roney, J M; Band, H R; Dasu, S; Datta, M; Eichenbaum, A M; Johnson, J R; Kutter, P E; Li, H; Liu, R; Lodovico, F Di; Mihalyi, A; Mohapatra, A K; Pan, Y; Prepost, R; Sekula, S J; von Wimmersperg-Toeller, J H; Wu, J; Wu, S L; Yu, Z; Neal, H; Christinziani, B

2004-06-04

We have performed a search for the rare leptonic decay B+-->mu(+)nu(mu) with data collected at the Upsilon(4S) resonance by the BABAR experiment at the PEP-II storage ring. In a sample of 88.4 x 10(6) BB pairs, we find no significant evidence for a signal and set an upper limit on the branching fraction B(B+-->my(+)nu(my))< 6.6 x 10(-6) at the 90% confidence level.

Quasiparticle random phase approximation uncertainties and their correlations in the analysis of 0{nu}{beta}{beta} decay

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faessler, Amand; Rodin, V.; Fogli, G. L.

2009-03-01

The variances and covariances associated to the nuclear matrix elements of neutrinoless double beta decay (0{nu}{beta}{beta}) are estimated within the quasiparticle random phase approximation. It is shown that correlated nuclear matrix elements uncertainties play an important role in the comparison of 0{nu}{beta}{beta} decay rates for different nuclei, and that they are degenerate with the uncertainty in the reconstructed Majorana neutrino mass.

NuLat: A Novel Design for a Reactor Anti-Neutrino Detector

NASA Astrophysics Data System (ADS)

Rountree, S. Derek; NuLat Collaboration

2015-04-01

NuLat is a proposed very-short baseline (3-10m) reactor electron antineutrino (anti-νe) experiment that will probe the current best fit for light sterile neutrino mixing, the 5 MeV excess seen in current short baseline reactor experiments, and serve as a portable surface detector for cooperative (~ 30m baseline) surface monitoring of reactors. The NuLat detector will use an optically segmented 3D Raghavan optical lattice (ROL) detector that channels light via total internal reflection from a scintillation event down the 3 primary axes to the detector faces. The high degree of segmentation allows for each voxel's energy to be determined independently of other voxels, thus providing high temporal and spatial resolution and energy reconstruction independent of position. NuLat detects anti-νe via inverse beta decay (IBD), which produces a positron and a neutron. Most of the time, the positron deposits its kinetic energy into a single voxel allowing superior derivation of the incident anti-νe's energy. The final state neutron is captured via (n, α) on 6 Li or 10 B after a characteristic delay time giving a coincidence tag. This talk will discuss the physics reach of NuLat using a solid loaded scintillator, and the timeline of the NuLat reactor anti-νe program. This research has been funded in part by the National Science Foundation on Award Numbers 1001394 and 1001078.

Effects of ionizing radiation in combination with Erufosine on T98G glioblastoma xenograft tumours: a study in NMRI nu/nu mice.

PubMed

Henke, Guido; Meier, Verena; Lindner, Lars H; Eibl, Hansjörg; Bamberg, Michael; Belka, Claus; Budach, Wilfried; Jendrossek, Verena

2012-10-18

Erufosine is a promising anticancer drug that increases the efficacy of radiotherapy in glioblastoma cell lines in vitro. Moreover, treatment of nude mice with repeated intraperitoneal or subcutaneous injections of Erufosine is well tolerated and yields drug concentrations in the brain tissue that are higher than the concentrations required for cytotoxic drug effects on glioblastoma cell lines in vitro. In the present study we aimed to evaluate the effects of a combined treatment with radiotherapy and Erufosine on growth and local control of T98G subcutaneous glioblastoma xenograft-tumours in NMRI nu/nu mice. We show that repeated intraperitoneal injections of Erufosine resulted in a significant drug accumulation in T98G xenograft tumours on NMRI nu/nu mice. Moreover, short-term treatment with 5 intraperitoneal Erufosine injections caused a transient decrease in the growth of T98G tumours without radiotherapy. Furthermore, an increased radiation-induced growth delay of T98G xenograft tumours was observed when fractionated irradiation was combined with short-term Erufosine-treatment. However, no beneficial drug effects on fractionated radiotherapy in terms of local tumour control were observed. We conclude that short-term treatment with Erufosine is not sufficient to significantly improve local control in combination with radiotherapy in T98G glioblastoma xenograft tumours. Further studies are needed to evaluate efficacy of extended drug treatment schedules.

Acetylation of Histone Deacetylase 1 Regulates NuRD Corepressor Complex Activity*

PubMed Central

Yang, Tao; Jian, Wei; Luo, Yi; Fu, Xueqi; Noguchi, Constance; Bungert, Jörg; Huang, Suming; Qiu, Yi

2012-01-01

Histone deacetylases (HDACs) play important roles in regulating cell proliferation and differentiation. The HDAC1-containing NuRD complex is generally considered as a corepressor complex and is required for GATA-1-mediated repression. However, recent studies also show that the NuRD complex is involved in GATA-1-mediated gene activation. We tested whether the GATA-1-associated NuRD complex loses its deacetylase activity and commits the GATA-1 complex to become an activator during erythropoiesis. We found that GATA-1-associated deacetylase activity gradually decreased upon induction of erythroid differentiation. GATA-1-associated HDAC1 is increasingly acetylated after differentiation. It has been demonstrated earlier that acetylated HDAC1 has no deacetylase activity. Indeed, overexpression of an HDAC1 mutant, which mimics acetylated HDAC1, promotes GATA-1-mediated transcription and erythroid differentiation. Furthermore, during erythroid differentiation, acetylated HDAC1 recruitment is increased at GATA-1-activated genes, whereas it is significantly decreased at GATA-1-repressed genes. Interestingly, deacetylase activity is not required for Mi2 remodeling activity, suggesting that remodeling activity may be required for both activation and repression. Thus, our data suggest that NuRD can function as a coactivator or repressor and that acetylated HDAC1 converts the NuRD complex from a repressor to an activator during GATA-1-directed erythroid differentiation. PMID:23014989

Chinese Milk Vetch Improves Plant Growth, Development and 15N Recovery in the Rice-Based Rotation System of South China.

PubMed

Xie, Zhijian; He, Yaqin; Tu, Shuxin; Xu, Changxu; Liu, Guangrong; Wang, Huimin; Cao, Weidong; Liu, Hui

2017-06-15

Chinese milk vetch (CMV) is vital for agriculture and environment in China. A pot experiment combined with 15 N labeling (including three treatments: control, no fertilizer N and CMV; 15 N-labeled urea alone, 15 NU; substituting partial 15 NU with CMV, 15 NU-M) was conducted to evaluate the impact of CMV on plant growth, development and 15 NU recovery in rice-based rotation system. The 15 NU-M mitigated oxidative damage by increasing antioxidant enzymes activities and chlorophyll content while decreased malondialdehyde content in rice root and shoot, increased the biomass, total N and 15 N uptake of plant shoots by 8%, 12% and 39% respectively, thus inducing a noticeable increase of annual 15 N recovery by 77% versus 15 NU alone. Remarkable increases in soil NH 4 + and populations of bacteria, actinomycetes and azotobacter were obtained in legume-rice rotation system while an adverse result was observed in soil NO 3 - content versus fallow-rice. CMV as green manure significantly increased the fungal population which was decreased with cultivating CMV as cover crop. Therefore, including legume cover crop in rice-based rotation system improves plant growth and development, annual N conservation and recovery probably by altering soil nitrogen forms plus ameliorating soil microbial communities and antioxidant system which alleviates oxidative damages in plants.

Millimeter-wave spectroscopy of CoNO Produced by UV laser photolysis of Co(CO){sub 3}NO

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sakamoto, Ai; Hayashi, Masato; Harada, Kensuke

2008-10-07

The rotational spectrum of cobalt mononitrosyl (CoNO) produced by ultraviolet photolysis of Co(CO){sub 3}NO was observed in the millimeter-wave region. Seven rotational transitions in the ground state ranging from J=6-5 to 12-11, with hyperfine splittings due to the Co nucleus (I=7/2), were detected in a supersonic jet environment, while higher-frequency transitions in the range from J=29-28 to 35-34 were measured in the ground, {nu}{sub 1}, {nu}{sub 2}, {nu}{sub 3}, and 2{nu}{sub 2} vibrational states using a free-space absorption cell. It was confirmed from the observed spectral pattern that the CoNO molecule has a linear structure with the electronic ground statemore » of {sup 1}{sigma}{sup +} symmetry. The rotational lines in the 2{nu}{sub 2}({sigma}) and {nu}{sub 3} states were observed to be perturbed by Fermi resonance. The equilibrium rotational constant B{sub e} is determined to be 4682.207(15) MHz. The CoN bond length is derived to be 1.5842 A assuming the NO bond length of 1.1823 A. A large nuclear spin-rotation interaction constant, C{sub I}=123.8(11) kHz, was determined, suggesting a {sup 1}{pi} electronic excited state lying close to the ground state.« less

Investigations of interhydrogen bond dynamical coupling effects in the polarized IR spectra of acetanilide crystals.

PubMed

Flakus, Henryk T; Michta, Anna

2010-02-04

This Article presents the investigation results of the polarized IR spectra of the hydrogen bond in acetanilide (ACN) crystals measured in the frequency range of the proton and deuteron stretching vibration bands, nu(N-H) and nu(N-D). The basic spectral properties of the crystals were interpreted quantitatively in terms of the "strong-coupling" theory. The model of the centrosymmetric dimer of hydrogen bonds postulated by us facilitated the explanation of the well-developed, two-branch structure of the nu(N-H) and nu(N-D) bands as well as the isotopic dilution effects in the spectra. On the basis of the linear dichroic and temperature effects in the polarized IR spectra of ACN crystals, the H/D isotopic "self-organization" effects were revealed. A nonrandom distribution of hydrogen isotope atoms (H or D) in the lattice was deduced from the spectra of isotopically diluted ACN crystals. It was also determined that identical hydrogen isotope atoms occupy both hydrogen bonds in the dimeric systems, where each hydrogen bond belongs to a different chain. A more complex fine structure pattern of nu(N-H) and nu(N-D) bands in ACN spectra in comparison with the spectra of other secondary amides (e.g., N-methylacetamide) can be explained in terms of the "relaxation" theory of the IR spectra of hydrogen-bonded systems.

Performance Evaluation of a PEM Scanner Using the NEMA NU 4—2008 Small Animal PET Standards

NASA Astrophysics Data System (ADS)

Luo, Weidong; Anashkin, Edward; Matthews, Christopher G.

2010-02-01

The recently published NEMA NU 4-2008 Standards has been specially designed for evaluating the performance of small animal PET scanners used in preclinical applications. In this paper, we report on the NU 4 performance of a clinical positron emission mammography (PEM) system. Since there are no PEM specific performance test protocols available, and the NU 2 protocol (intended for whole-body PET scanners) cannot be applied without modification due to the compact design of the PEM scanner, we decided to evaluate the NU 4 Standards as an alternative. We obtained the following results: Trans-axial spatial resolution 1.8 mm FWHM for high resolution reconstruction mode and 2.4 mm FWHM for standard resolution reconstruction mode with no significant variation within the field of view. The total system sensitivity was 0.16 cps/Bq. In image quality testing, the uniformity was found to be 3.9% STD at the standard resolution mode and 5.6% at the high resolution mode when measured with a 34 mm paddle separation. The NEMA NU 4-2008 Standards were found to be a practicable tool to evaluate the performance of the PEM scanner after some modifications to address the specifics of its detector configuration. Furthermore, the PEM scanner's in-plane spatial resolution was comparable to other small animal PET scanners with good image quality.

Temperature dependence of Lorentz air-broadening and pressure-shift coefficients of (12)CH4 lines in the 2.3-micron spectral region

NASA Technical Reports Server (NTRS)

Devi, V. Malathy; Benner, D. Chris; Smith, M. A. H.; Rinsland, C. P.

1994-01-01

High-resolution (0.01/cm) absorption spectra of lean mixtures of CH4 in dry air were recorded with the McMath-Pierce Fourier transform spectrometer (FTS) of the National Solar Observatory on Kitt Peak at various temperatures between 24 and -61 C. The spectra have been analyzed to determine the values at room temperature of pressure-broadened widths and pressure-induced shifts of more than 740 transitions. The temperature dependence of air-broadened widths and pressure-induced shifts was deduced for approx. 370 transitions in the nu(sub 1) + nu(sub 4), nu(sub 3) + nu(sub 4), and nu(sub 2) + nu(sub 3) bands of (12)CH4 located between 4118 and 4615/cm. These results were obtained by analyzing a total of 29 spectra simultaneously using a multi-spectral non-linear least-squares fitting technique. This new technique allowed the determination of correlated spectral line parameters (e.g. intensity and broadening coefficient) better than the procedure of averaging values obtained by fitting the spectra individually. This method also provided a direct determination of the uncertainties in the retrieved parameters due to random errors. For each band analysed in this study the dependence of the various spectral line parameters upon the tetrahedral symmetry species and the rotational quantum numbers of the transitions is also presented.

The heating and acceleration actions of the solar plasma wave by QFT

NASA Astrophysics Data System (ADS)

Chen, Shao-Guang

I deduce the new gravitational formula from the variance in mass of QFT and GR (H05-0029-08, E15-0039 -08, E14-0032-08, D31-0054-10) in the partial differential: f (QFT) = f (GR) = delta∂ (m v)/delta∂ t = f _{P} + f _{C} , f _{P} = m delta∂ v / delta∂ t = - ( G m M /r (2) ) r / r, f _{C} = v delta∂ m / delta∂ t = - ( G mM / r (2) ) v / c (1), f (QFT) is the quasi-Casimir pressure of net virtual neutrinos nuν _{0} flux (after counteract contrary direction nuν _{0}). f (GR) is equivalent to Einstein’s equation as a new version of GR. GR can be inferred from Eq.(1) thereby from QFT, but QFT cannot be inferred from Eq.(1) or GR. f (QFT) is essential but f (GR) is phenomenological. Eq.(1) is obtained just by to absorb the essence of corpuscule collided gravitation origin ism proposed by Fatio in 1690 and 1920 Majorana’s experiment concept about gravitational shield effect again fuse with QFT. Its core content is that the gravity produced by particles collide cannot linear addition, i.e., Eq.(1) with the adding nonlinearity caused by the variable mass to replace the nonlinearity of Einstein’s equation and the nonlinear gravitation problems can be solved using the classical gradual approximation of alone f _{P} and alone f _{C}. Such as the calculation of advance of the perihelion of QFT, let the gravitational potential U = - G M /r which is just the distribution density of net nuν _{0} flux. From SR we again get Eq.(1): f (QFT) = f _{P} + f _{C}, f _{P} = - m ( delta∂ U / delta∂ r) r / r, f _{C} = - m ( delta∂U / delta∂ r) v / c , U = (1 - betaβ (2) )V, V is the Newtonian gravitational potential. f_{ P} correspond the change rate of three-dimensional momentum p, f_{C} correspond the change rate of fourth dimensional momentum i m c which show directly as a dissipative force of mass change. In my paper ‘To cross the great gap between the modern physics and classic physics, China Science &Technology Overview 129 85-91(2011)’ with the measuring value of one-way velocity of light (H05-0006-08) to replace the infinity value of light speed measured by Galileo in 1607, thereby the mass m in NM will become variable m. Or else, the energy of electron in accelerator should not larger than 0.51Mev which conflict with the experimental fact. According to the variable mass and the definition of force we again get Eq.(1) from NM without hypothesis, i.e., NM is generalized in which Galileo coordinates transformation and the action at a distance will be of no effect. Eq.(1) has more reliable experimental base and generalized NM may be applied to the high-speed and the microscopic conditions. Because of the result of a test of GR with use of a hydrogen-maser frequency standard in a spacecraft launched nearly vertically upward to 10000 km (R. F. C. Vessot et.al., Phys. Rev. Lett. 45, 2081 (1980)), the isotropy of one-way velocity of light had been validated at the 1*10 (-10) level (D2.4-0030-12, H0.1-0009-12, H0.2-0008-12). Again from the Lorentz transformation (H01-0006-08) and the uncertainty principle (H05-0036-10) deduced from the metrical results of Doppler effects, SR and QM, thereby QFT and GR, all become the inferential theorems from generalized NM. Eq.(1) is as a bridge to join the modern physics and classical physics. In my paper ‘Basal electric and magnetic fields of celestial bodies come from positive-negative charge separation caused by gravitation of quasi-Casimir pressure in weak interaction’ (D31-0054-10): According to QFT the gravitation is the statistic average pressure collided by net virtual neutrinos nuν _{0} flux, the net nuν _{0} flux can press a part freedom electrons in plasma of ionosphere into the surface of celestial bodies, the static electric force of redundant positive ions prevents electrons further falling and till reach the equilibrium of stable spatial charge distribution, which is just the cause of the geomagnetic field and the geo-electric field. In the solar surface plasma add the negative charge from ionosphere electrons again rotate, thereby come into being the solar basal magnetic field. The solar surface plasma with additional electrons get the dynamic balance between the upwards force of stable positive charge distribution in the solar upside gas and the downwards force of the vacuum net nuν _{0} flux pressure (solar gravity). When the Jupiter enter into the connecting line of Sun and the center of Galaxy, the pressure (solar gravity) observed from earth will weaken because of the Jupiter stop (shield) the most net nuν _{0} flux which shoot to Sun from the center of Galaxy. The dynamic balance of forces on the solar surface plasma at once is broken and the plasma will upwards eject as the solar wind with redundant negative charge, at the same time, the solar surface remain a cavity as a sunspot whorl with the positive charge relative to around plasma. The whorl caused by that the reaction of plasma eject front and upwards with the different velocity at different latitude of solar rotation, leads to the cavity around in the downwards and backwards helix movement. The solar rotation more slow, when the cavity is filled by around plasma in the reverse turn direction and return to small negative charge, the Jupiter at front had been produced a new cavity. Thereby we had observe the sunspot pair with different directions whorl and different magnetic polarity. Jupiter possess half mass of all planets in solar system, its action to stop net nuν _{0} flux is primary, then Jupiter’s period of 11.8 sidereal years accord basically with the period of sunspot eruptions. The negative electric solar plasma upwards eject into the positive electric ionosphere, the upwards force will decrease and the downwards net nuν_{0} flux pressure again to be large than the upwards force, it makes the solar plasma again downwards and ceaselessly up-down vibrating. At the same time, in the solar magnetic field the positive - negative charge of the outflow solar plasma will left-right separate by Lorentz force and by the feedback mechanism of Lorentz force the positive - negative charge will left-right vibrate. The plasma on the move will accompany with up-down and left-right vibrating and become the wave. Though the frequent of the plasma wave is not high, but its heating and acceleration actions will be not less then that of the microwave and laser because of its mass and energy far large then that of the microwave and laser.

Think-Aloud Process Superior to Thought-Listing in Increasing Children's Critical Processing of Advertising

ERIC Educational Resources Information Center

Rozendaal, Esther; Buijzen, Moniek; Valkenburg, Patti M.

2012-01-01

This study develops and tests a model of children's critical processing of advertising. Within this model, 2 paths to reduced advertising susceptibility (i.e., attitude toward the advertised brand) were hypothesized: a cognitive path and an affective path. The secondary aim was to compare these paths for different thought verbalization processes:…

The ecological impacts of primary education facilities based on a child-friendly neighborhood unit criteria in Surakarta

NASA Astrophysics Data System (ADS)

Rini, E. F.; Putri, R. A.; Mulyanto; Handayani, N.

2018-03-01

A city should accommodate the citizen needs, especially for children. The absence of elementary school in a neighborhood unit (NU) will increase the use of transportation by children in the NU, every day at the same time. This activity will produce large quantities of - carbon dioxide (CO2) that can trigger climate change. This article aims at discovering the ecological impacts of CO2 emitted from the transportation used by children when commuting to their school, based on the conformity of each NU to the criteria of the a child-friendly city. Quantitative and spatial analysis techniques were employed in these four stages: (1) dividing the NU; (2) constructing the NU’s typology based on a child-friendly criteria; (3) identifying the characteristic of children movements in each NU when accessing their elementary school; and (4) analyzing the ecological impacts (in CO2 form). The result shows that 88.14% of CO2 emissions in Surakarta can be reduced by interventions through the fulfillment of all NU’s child-friendly criterias.

Status of the nuSTORM Facility and a Possible Extension for Long-Baseline $$\

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bross, Alan D.; Liu, Ao; Lagrange, Jean-Baptiste

2015-11-03

Neutrino beams produced from the decay of muons in a racetrack-like decay ring (the so called Neutrino Factory) provide a powerful way to study neutrino oscillation physics and, in addition, provide unique beams for neutrino interaction studies. The Neutrinos from STORed Muons (nuSTORM) facility uses a neutrino factory-like design. Due to the particular nature of nuSTORM, it can also provide an intense, very pure, muon neutrino beam from pion decay. This so-called “Neo-conventional" muon neutrino beam from nuSTORM makes nuSTORM a hybrid neutrino factory. In this paper we describe the facility and give a detailed description of the neutrino beammore » fluxes that are available and the precision to which these fluxes can be determined. We then present sensitivity plots that indicated how well the facility can perform for short-baseline oscillation searches and show its potential for a neutrino interaction physics program. Finally, we comment on the performance potential of the "Neo-conventional" muon neutrino beam optimized for long- baseline neutrino-oscillation physics.« less

Methane Oxidation to Methanol Catalyzed by Cu-Oxo Clusters Stabilized in NU-1000 Metal-Organic Framework.

PubMed

Ikuno, Takaaki; Zheng, Jian; Vjunov, Aleksei; Sanchez-Sanchez, Maricruz; Ortuño, Manuel A; Pahls, Dale R; Fulton, John L; Camaioni, Donald M; Li, Zhanyong; Ray, Debmalya; Mehdi, B Layla; Browning, Nigel D; Farha, Omar K; Hupp, Joseph T; Cramer, Christopher J; Gagliardi, Laura; Lercher, Johannes A

2017-08-02

Copper oxide clusters synthesized via atomic layer deposition on the nodes of the metal-organic framework (MOF) NU-1000 are active for oxidation of methane to methanol under mild reaction conditions. Analysis of chemical reactivity, in situ X-ray absorption spectroscopy, and density functional theory calculations are used to determine structure/activity relations in the Cu-NU-1000 catalytic system. The Cu-loaded MOF contained Cu-oxo clusters of a few Cu atoms. The Cu was present under ambient conditions as a mixture of ∼15% Cu + and ∼85% Cu 2+ . The oxidation of methane on Cu-NU-1000 was accompanied by the reduction of 9% of the Cu in the catalyst from Cu 2+ to Cu + . The products, methanol, dimethyl ether, and CO 2 , were desorbed with the passage of 10% water/He at 135 °C, giving a carbon selectivity for methane to methanol of 45-60%. Cu oxo clusters stabilized in NU-1000 provide an active, first generation MOF-based, selective methane oxidation catalyst.