Characterization of nuclear graphite elastic properties using laser ultrasonic methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeng, Fan W; Han, Karen; Olasov, Lauren R

2015-01-01

Laser ultrasonic methods have been used to characterize the elastic behaviors of commercially-available and legacy nuclear graphites. Since ultrasonic techniques are sensitive to various aspects of graphite microstructure including preferred grain orientation, microcrack orientation and porosity, laser ultrasonics is a candidate technique for monitoring graphite degradation and structural integrity in environments expected in high-temperature, gas-cooled nuclear reactors. Aspects of materials texture can be assessed by studying ultrasonic wavespeeds as a function of propagation direction and polarization. Shear wave birefringence measurements, in particular, can be used to evaluate elastic anisotropy. In this work, laser ultrasonic measurements of graphite moduli have beenmore » made to provide insight into the relationship between the microstructures and the macroscopic stiffnesses of these materials. In particular, laser ultrasonic measurements have been made using laser line sources to produce shear waves with specific polarizations. By varying the line orientation relative to the sample, shear wave birefringence measurements have been recorded. Results from shear wave birefringence measurements show that an isostatically molded graphite, such as PCIB, behaves isotropically, while an extruded graphite, such as H-451, displays significant ultrasonic texture. Graphites have complicated microstructures that depend on the manufacturing processes used, and ultrasonic texture in these materials could originate from grain orientation and preferred microcrack alignment. Effects on material isotropy due to service related microstructural changes are possible and the ultimate aim of this work is to determine the degree to which these changes can be assessed nondestructively using laser ultrasonics measurements« less

Depth profiling of high energy nitrogen ions implanted in the <1 0 0>, <1 1 0> and randomly oriented silicon crystals

NASA Astrophysics Data System (ADS)

Erić, M.; Petrović, S.; Kokkoris, M.; Lagoyannis, A.; Paneta, V.; Harissopulos, S.; Telečki, I.

2012-03-01

This work reports on the experimentally obtained depth profiles of 4 MeV 14N2+ ions implanted in the <1 0 0>, <1 1 0> and randomly oriented silicon crystals. The ion fluence was 1017 particles/cm2. The nitrogen depth profiling has been performed using the Nuclear Reaction Analysis (NRA) method, via the study of 14N(d,α0)12C and 14N(d,α1)12C nuclear reactions, and with the implementation of SRIM 2010 and SIMNRA computer simulation codes. For the randomly oriented silicon crystal, change of the density of silicon matrix and the nitrogen "bubble" formation have been proposed as the explanation for the difference between the experimental and simulated nitrogen depth profiles. During the implantation, the RBS/C spectra were measured on the nitrogen implanted and on the virgin crystal spots. These spectra provide information on the amorphization of the silicon crystals induced by the ion implantation.

The Colombian nuclear scenario: Challenges and opportunities

NASA Astrophysics Data System (ADS)

Martinez, Isabel

2016-07-01

In Colombia, the absence of nuclear-oriented policies based on technical knowledge, the closing of the Nuclear Affairs Institute (1956-1998), the association of the word "nuclear" with weapons, plus the country's last six decades of internal conflict and narcotraffic have discourage the technical, social and environmental nuclear advance. However, there are technical, social and economic national challenges that could be faced by the present nuclear technical capacities.

Resonant polarization transfer from electron spins to nuclear spins-or to muon spins-in semiconductors

NASA Astrophysics Data System (ADS)

Henstra, A.; Wenckebach, W. Th.

1991-02-01

A review is given of newly developed pulsed Electron Spin Resonance (ESR) methods for dynamic polarization of nuclear spins. The application of two of these methods, Nuclear Orientation Via Electron spin Locking (NOVEL) and the Integrated Solid Effect (ISE), for the polarization of nuclear spins in semiconductors is discussed in more detail. It is proposed to use these methods to study the ESR spectrum of unpaired electrons in the vicinity of muons that are bound in a solid. Thus, ESR would be observed with a sensitivity which is enhanced by about ten orders of magnitude compared to conventional ESR.

The electron-spin--nuclear-spin interaction studied by polarized neutron scattering.

PubMed

Stuhrmann, Heinrich B

2007-11-01

Dynamic nuclear spin polarization (DNP) is mediated by the dipolar interaction of paramagnetic centres with nuclear spins. This process is most likely to occur near paramagnetic centres at an angle close to 45 degrees with respect to the direction of the external magnetic field. The resulting distribution of polarized nuclear spins leads to an anisotropy of the polarized neutron scattering pattern, even with randomly oriented radical molecules. The corresponding cross section of polarized coherent neutron scattering in terms of a multipole expansion is derived for radical molecules in solution. An application using data of time-resolved polarized neutron scattering from an organic chromium(V) molecule is tested.

Manned space flight nuclear system safety. Volume 4: Space shuttle nuclear system transportation. Part 1: Space shuttle nuclear safety

NASA Technical Reports Server (NTRS)

1972-01-01

An analysis of the nuclear safety aspects (design and operational considerations) in the transport of nuclear payloads to and from earth orbit by the space shuttle is presented. Three representative nuclear payloads used in the study were: (1) the zirconium hydride reactor Brayton power module, (2) the large isotope Brayton power system and (3) small isotopic heat sources which can be a part of an upper stage or part of a logistics module. Reference data on the space shuttle and nuclear payloads are presented in an appendix. Safety oriented design and operational requirements were identified to integrate the nuclear payloads in the shuttle mission. Contingency situations were discussed and operations and design features were recommended to minimize the nuclear hazards. The study indicates the safety, design and operational advantages in the use of a nuclear payload transfer module. The transfer module can provide many of the safety related support functions (blast and fragmentation protection, environmental control, payload ejection) minimizing the direct impact on the shuttle.

Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 2. Nuclear Weapons Effects and Shelter.

ERIC Educational Resources Information Center

Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

Basic information about nuclear weapons is presented so that their effects can be meaningfully related to the defensive countermeasures which will be most effective against them. Major topics include: (1) Explosive power of nuclear weapons, (2) Major effects of nuclear explosions, (3) Two basic types of nuclear explosions, (4) Contrast between air…

Geometry and solid angle corrections for accurate measurement of multipole and parity mixing ratios using nuclear orientation

NASA Astrophysics Data System (ADS)

Roccia, S.; Gaulard, C.; Étilé, A.; Chakma, R.

2017-07-01

In the context of nuclear orientation, we propose a new method to correct the multipole mixing ratios for asymmetries in the geometry of the setup but also in the detection system. This method is also robust against temperature fluctuations, beam intensity fluctuations and uncertainties in the nuclear structure of the nuclei. Additionally, this method provides a natural way to combine data from different detectors and make good use of all available statistics. We could use this method to demonstrate the accuracy that can be reached with the PolarEx setup now installed at the ALTO facility.

Conformational distribution of n-hexane in a nematic liquid crystal obtained from nuclear spin dipolar couplings by Monte Carlo sampling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luzar, M.; Rosen, M.E.; Caldarelli, S.

Motionally averaged proton-proton dipolar couplings measured by nuclear magnetic resonance (NMR) spectroscopy can provide information about the conformations and orientations sampled by partially oriented molecules. In this study, the measured dipolar couplings between pairs of protons on n-hexane dissolved in a nematic liquid crystal solvent are used as constraints in a Monte Carlo sampling of the conformations and orientations of n-hexane. Rotation about each carbon-carbon bond in the molecule is modeled by the complete sinusoidal torsional potential of Ryckaert and Bellemans rather than by the three-state rotational isomeric states (RIS) model that has been used in previous studies. Comparison ofmore » the results of the simulations using the Ryckaert-Bellemans potential and the RIS model indicates little difference in the values of the adjustable parameters and the quality of the fits to the experimental data. The primary difference between the models appears in the calculated conformer probability distributions for n-hexane, highlighting the importance of the exact shape of the torsional potential used to model carbon-carbon bond rotation in organic molecules. 23 refs., 3 figs., 4 tabs.« less

Progress and challenges of nuclear science development in Vietnam - an outlook on the occassion of the 10-th anniversary of the Dalat Nuclear Research Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hien, P.D.

1994-12-31

Over ten years since the commissioning of the Dalat nuclear research reactor a number of nuclear techniques have been developed and applied in Vietnam Manufacturing of radioisotopes and nuclear instruments, development of isotope tracer and nuclear analytical techniques for environmental studies, exploitation of filtered neutron beams, ... have been major activities of reactor utilizations. Efforts made during ten years of reactor operation have resulted also in establishing and sustaining the applications of nuclear techniques in medicine, industry, agriculture, etc. The successes achieved and lessons teamed over the past ten years are discussed illustrating the approaches taken for developing the nuclearmore » science in the conditions of a country having a very low national income and experiencing a transition from a centrally planned to a market-oriented economic system.« less

Multiphysics Object-Oriented Simulation Environment (MOOSE)

ScienceCinema

None

2017-12-09

Nuclear reactor operators can expand safety margins with more precise information about how materials behave inside operating reactors. INL's new simulation platform makes such studies easier & more informative by letting researchers "plug-n-play" their mathematical models, skipping years of computer code development.

Circumnuclear Structures in Megamaser Host Galaxies

NASA Astrophysics Data System (ADS)

Pjanka, Patryk; Greene, Jenny E.; Seth, Anil C.; Braatz, James A.; Henkel, Christian; Lo, Fred K. Y.; Läsker, Ronald

2017-08-01

Using the Hubble Space Telescope, we identify circumnuclear (100-500 pc scale) structures in nine new H2O megamaser host galaxies to understand the flow of matter from kpc-scale galactic structures down to the supermassive black holes (SMBHs) at galactic centers. We double the sample analyzed in a similar way by Greene et al. and consider the properties of the combined sample of 18 sources. We find that disk-like structure is virtually ubiquitous when we can resolve <200 pc scales, in support of the notion that non-axisymmetries on these scales are a necessary condition for SMBH fueling. We perform an analysis of the orientation of our identified nuclear regions and compare it with the orientation of megamaser disks and the kpc-scale disks of the hosts. We find marginal evidence that the disk-like nuclear structures show increasing misalignment from the kpc-scale host galaxy disk as the scale of the structure decreases. In turn, we find that the orientation of both the ˜100 pc scale nuclear structures and their host galaxy large-scale disks is consistent with random with respect to the orientation of their respective megamaser disks.

Simulation of orientational coherent effects via Geant4

NASA Astrophysics Data System (ADS)

Bagli, E.; Asai, M.; Brandt, D.; Dotti, A.; Guidi, V.; Verderi, M.; Wright, D.

2017-10-01

Simulation of orientational coherent effects via Geant4 beam manipulation of high-and very-high-energy particle beams is a hot topic in accelerator physics. Coherent effects of ultra-relativistic particles in bent crystals allow the steering of particle trajectories thanks to the strong electrical field generated between atomic planes. Recently, a collimation experiment with bent crystals was carried out at the CERN-LHC, paving the way to the usage of such technology in current and future accelerators. Geant4 is a widely used object-oriented tool-kit for the Monte Carlo simulation of the interaction of particles with matter in high-energy physics. Moreover, its areas of application include also nuclear and accelerator physics, as well as studies in medical and space science. We present the first Geant4 extension for the simulation of orientational effects in straight and bent crystals for high energy charged particles. The model allows the manipulation of particle trajectories by means of straight and bent crystals and the scaling of the cross sections of hadronic and electromagnetic processes for channeled particles. Based on such a model, an extension of the Geant4 toolkit has been developed. The code and the model have been validated by comparison with published experimental data regarding the deflection efficiency via channeling and the variation of the rate of inelastic nuclear interactions.

An analysis of 12th-grade students' reasoning styles and competencies when presented with an environmental problem in a social and scientific context

NASA Astrophysics Data System (ADS)

Yang, Fang-Ying

This study examined reasoning and problem solving by 182 12th grade students in Taiwan when considering a socio-scientific issue regarding the use of nuclear energy. Students' information preferences, background characteristics, and eleven everyday scientific thinking skills were scrutinized. It was found most participants displayed a willingness to take into account both scientific and social information in reasoning the merits of a proposed construction of a nuclear power plant. Students' reasoning scores obtained from the "information reasoning style" test ranged from -0.5 to 1.917. And, the distribution was approximately normal with mean and median at around 0.5. For the purpose of categorization, students whose scores were within one standard deviation from the mean were characterized as having a "equally disposed" reasoning style. One hundred and twenty-five subjects, about 69%, belonged to this category. Students with scores locating at the two tails of the distribution were assigned to either the "scientifically oriented" or the "socially oriented" reasoning category. Among 23 background characteristics investigated using questionnaire data and ANOVA statistical analysis, only students' science performance and knowledge about nuclear energy were statistically significantly related to their information reasoning styles (p < 0.05). The assessed background characteristics addressed dimensions such as gender, academic performances, class difference, future education, career expectation, commitment to study, assessment to educational enrichment, family conditions, epistemological views about science, religion, and the political party preference. For everyday scientific thinking skills, interview data showed that both "scientifically oriented" students and those who were categorized as "equally disposed to using scientific and social scientific sources of data" displayed higher frequencies than "socially oriented" ones in using these skills, except in the use of the "multidisciplinary thinking" skill. Among the 11 skills assessed, the "scientifically oriented" students outperformed the "equally disposed" ones only in the use of 3 thinking skills; namely, searching for or recalling scientific concepts/evidence, recognizing and evaluating alternatives, and making conclusions based on the scientific intuition.

Detection of alterations in human sperm using magnetic orientation techniques

NASA Astrophysics Data System (ADS)

Sakhnini, Lama; Dairi, Maheen; Manaa, Hacene

2007-09-01

In this study we report on magnetic orientation of human sperms. Samples were taken from 17 donors. Normal human sperms became oriented with their long axis perpendicular to the magnetic field ( 1 Tesla maximum). Total orientation was achieved with magnetic field at about one Tesla, while for abnormal sperms the magnetic behavior was different. The dependence of the measured degree of orientation on the intensity of the magnetic field was in good agreement with the theoretical equation for the magnetic orientation of diamagnetic substances. As a result for a numerical analysis based on the equation, the anisotropic diamagnetic susceptibility of normal sperm was found to be ▵ χ= 8×10 -20 J/T2. The degree of orientation was influenced by the alterations in the shape of the head, body or the tail. It has been suggested that the DNA in the sperm head retain the strong magnetic anisotropy to counter balance the magnetic anisotropy retained by flagellum microtubules. Recent studies demonstrated a well-defined nuclear architecture in human sperm nucleus, where the head morphology has significant correlation with sperm chromatin structure assay SCSA. Then as the methods to evaluate SCSA can be difficult and expensive our simple magnetic orientation technique can be an alternative to diagnose alteration in DNA.

Room-temperature coupling between electrical current and nuclear spins in OLEDs

NASA Astrophysics Data System (ADS)

Malissa, H.; Kavand, M.; Waters, D. P.; van Schooten, K. J.; Burn, P. L.; Vardeny, Z. V.; Saam, B.; Lupton, J. M.; Boehme, C.

2014-09-01

The effects of external magnetic fields on the electrical conductivity of organic semiconductors have been attributed to hyperfine coupling of the spins of the charge carriers and hydrogen nuclei. We studied this coupling directly by implementation of pulsed electrically detected nuclear magnetic resonance spectroscopy in organic light-emitting diodes (OLEDs). The data revealed a fingerprint of the isotope (protium or deuterium) involved in the coherent spin precession observed in spin-echo envelope modulation. Furthermore, resonant control of the electric current by nuclear spin orientation was achieved with radiofrequency pulses in a double-resonance scheme, implying current control on energy scales one-millionth the magnitude of the thermal energy.

Reliability database development for use with an object-oriented fault tree evaluation program

NASA Technical Reports Server (NTRS)

Heger, A. Sharif; Harringtton, Robert J.; Koen, Billy V.; Patterson-Hine, F. Ann

1989-01-01

A description is given of the development of a fault-tree analysis method using object-oriented programming. In addition, the authors discuss the programs that have been developed or are under development to connect a fault-tree analysis routine to a reliability database. To assess the performance of the routines, a relational database simulating one of the nuclear power industry databases has been constructed. For a realistic assessment of the results of this project, the use of one of existing nuclear power reliability databases is planned.

Proton electron nuclear double resonance from nitrosyl horse heart myoglobin: the role of His-E7 and Val-E11.

PubMed Central

Flores, M; Wajnberg, E; Bemski, G

2000-01-01

Electron nuclear double resonance (ENDOR) spectroscopy has been used to study protons in nitrosyl horse heart myoglobin (MbNO). (1)H ENDOR spectra were recorded for different settings of the magnetic field. Detailed analysis of the ENDOR powder spectra, using computer simulation, based on the "orientation-selection" principle, leads to the identification of the available protons in the heme pocket. We observe hyperfine interactions of the N(HisF8)-Fe(2+)-N(NO) complex with five protons in axial and with eight protons in the rhombic symmetry along different orientations, including those of the principal axes of the g-tensor. Protons from His-E7 and Val-E11 residues are identified in the two symmetries, rhombic and axial, exhibited by MbNO. Our results indicate that both residues are present inside the heme pocket and help to stabilize one particular conformation. PMID:10733988

The Race Against Nuclear Terror

DTIC Science & Technology

2005-09-01

orientation (central planning vs . market economy); or (3) systemic or state-specific incentives, such as new norms, emerge that diminish the appeal of... franchised version of the nuclear “Wal-Mart” cannot be discounted. Yet, if we are 49 Christopher Clary. “Dr... independent capability. To do so would require specific enrichment technology developed indigenously or obtained illegally. Most exporters of nuclear

Analytic treatment of nuclear spin-lattice relaxation for diffusion in a cone model

NASA Astrophysics Data System (ADS)

Sitnitsky, A. E.

2011-12-01

We consider nuclear spin-lattice relaxation rate resulted from a diffusion equation for rotational wobbling in a cone. We show that the widespread point of view that there are no analytical expressions for correlation functions for wobbling in a cone model is invalid and prove that nuclear spin-lattice relaxation in this model is exactly tractable and amenable to full analytical description. The mechanism of relaxation is assumed to be due to dipole-dipole interaction of nuclear spins and is treated within the framework of the standard Bloemberger, Purcell, Pound-Solomon scheme. We consider the general case of arbitrary orientation of the cone axis relative the magnetic field. The BPP-Solomon scheme is shown to remain valid for systems with the distribution of the cone axes depending only on the tilt relative the magnetic field but otherwise being isotropic. We consider the case of random isotropic orientation of cone axes relative the magnetic field taking place in powders. Also we consider the cases of their predominant orientation along or opposite the magnetic field and that of their predominant orientation transverse to the magnetic field which may be relevant for, e.g., liquid crystals. Besides we treat in details the model case of the cone axis directed along the magnetic field. The latter provides direct comparison of the limiting case of our formulas with the textbook formulas for free isotropic rotational diffusion. The dependence of the spin-lattice relaxation rate on the cone half-width yields results similar to those predicted by the model-free approach.

Effect of deformation and orientation on spin orbit density dependent nuclear potential

NASA Astrophysics Data System (ADS)

Mittal, Rajni; Kumar, Raj; Sharma, Manoj K.

2017-11-01

Role of deformation and orientation is investigated on spin-orbit density dependent part VJ of nuclear potential (VN=VP+VJ) obtained within semi-classical Thomas Fermi approach of Skyrme energy density formalism. Calculations are performed for 24-54Si+30Si reactions, with spherical target 30Si and projectiles 24-54Si having prolate and oblate shapes. The quadrupole deformation β2 is varying within range of 0.023 ≤ β2 ≤0.531 for prolate and -0.242 ≤ β2 ≤ -0.592 for oblate projectiles. The spin-orbit dependent potential gets influenced significantly with inclusion of deformation and orientation effect. The spin-orbit barrier and position gets significantly influenced by both the sign and magnitude of β2-deformation. Si-nuclei with β22<0 have higher spin-orbit barrier (compact spin-orbit configuration) in comparison to systems with β2>0. The possible role of spin-orbit potential on barrier characteristics such as barrier height, barrier curvature and on the fusion pocket is also probed. In reference to prolate and oblate systems, the angular dependence of spin-orbit potential is further studied on fusion cross-sections.

Nuclear resonant forward scattering of synchrotron radiation by randomly oriented iron complexes which exhibit nuclear Zeeman interaction

NASA Astrophysics Data System (ADS)

Haas, M.; Realo, E.; Winkler, H.; Meyer-Klaucke, W.; Trautwein, A. X.; Leupold, O.; Rüter, H. D.

1997-12-01

An expression for the amplitude of a pulse of synchrotron radiation (SR) coherently scattered in forward direction by a randomly oriented Mössbauer absorber is derived from the theory of γ optics. It is assumed that the hyperfine splittings present in the Mössbauer nuclei can be described in the framework of the spin-Hamiltonian formalism. In the general case of a thick Mössbauer sample, which consists of randomly oriented paramagnetic iron-containing molecules (for example, a frozen solution of a 57Fe protein) in an applied magnetic field, the response of this sample on an incident monochromatic and fully polarized SR beam cannot be given analytically because of the integrations involved. The way to evaluate nuclear forward-scattering spectra for this general case numerically is outlined and results of calculations with a corresponding program package called SYNFOS are shown and compared with experimental results obtained by measurements of the high-spin iron (II) ``picket-fence'' porphyrin [Fe(CH3COO)TPpivP]- in an applied field of 6 T.

Lift-based up-ender and methods using same to manipulate a shipping container containing unirradiated nuclear fuel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nilles, Michael J.

A shipping container containing an unirradiated nuclear fuel assembly is lifted off the ground by operating a crane to raise a lifting tool comprising a winch. The lifting tool is connected with the shipping container by a rigging line connecting with the shipping container at a lifting point located on the shipping container between the top and bottom of the shipping container, and by winch cabling connecting with the shipping container at the top of the shipping container. The shipping container is reoriented by operating the winch to adjust the length of the winch cabling so as to rotate themore » shipping container about the lifting point. Shortening the winch cabling rotates the shipping container about the lifting point from a horizontal orientation to a vertical orientation, while lengthening the winch cabling rotates the shipping container about the lifting point from the vertical orientation to the horizontal orientation.« less

The U. S. nuclear industry; A changing complexion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zorpette, G

This article addresses the changes which have occurred in the U.S. nuclear industry as a response to the decline in the construction of new plants. The author focuses on the segments of the industry which chiefly design and produce nuclear power plants, the architect-engineers and the suppliers, and how they have become more service oriented in response to the construction decline. The movement toward diversification to non-nuclear industries is also discussed.

Synthesis of new oligothiophene derivatives and their intercalation compounds: Orientation effects

USGS Publications Warehouse

Ibrahim, M.A.; Lee, B.-G.; Park, N.-G.; Pugh, J.R.; Eberl, D.D.; Frank, A.J.

1999-01-01

The orientation dependence of intercalated oligothiophene derivatives in vermiculite and metal disulfides MS2 (M = Mo, Ti and Zr) on the pendant group on the thiophene ring and the host material was studied by X-ray diffraction (XRD) and solid state nuclear magnetic resonance spectroscopy. Amino and nitro derivatives of bi-, ter- and quarter-thiophenes were synthesized for the first time. The amino-oligothiophenes were intercalated into vermiculite by an exchange reaction with previously intercalated octadecylammonium vermiculite and into MS2 by the intercalation-exfoliation technique. Analysis of the XRD data indicates that a monolayer of amino-oligothiophene orients perpendicularly to the silicate surface in vermiculite and lies flat in the van der Waals gap of MS2.

Aging and Economics: The Future Is Now.

ERIC Educational Resources Information Center

Wall, Ronald W.

1986-01-01

Examines the economic and social implications of world aging (social welfare costs, strain on family finances, diversion of youth-oriented expenditures to elderly-oriented expenditures, need for containment of inflation, return to a nuclear family) and the role of home economists in preparing people for this future. (CT)

Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 1. Civil Defense - Protection Against What?

ERIC Educational Resources Information Center

Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

An explanation of the need for civil defense in nuclear and natural disasters is presented. A brief historical background of civil defense is given. Major topics include: (1) Types of disasters, (2) Probable objectives of a nuclear attack on the United States, (3) The major defensive measures against a nuclear attack, (4) Some reasons for low…

The Formation Mechanism of Nuclear Rings

NASA Astrophysics Data System (ADS)

Regan, M. W.; Teuben, P. J.

2001-12-01

Nuclear star forming rings are found in many barred galaxies. In some of these galaxies the majority of the star formation is occurring in the ring. Although there is circumstantial evidence that an inner Lindblad resonance is required for the ring to form, very little work has been done on why this is so. In this talk we will present some of the first analytical work on why, where, and under what conditions rings form. By using both hydrodynamic simulations and numerically integrated stellar orbits we are able to show the relationship between the extent of the X2 orbit family and the nuclear ring radius. This provides the first clear evidence that the ring is formed by the conflict between gas on X2 orbits oriented perpendicular to the bar major axis and gas on X1 orbits oriented along the bar major axis.

Standardization and economics of nuclear spacecraft: Executive summary

NASA Technical Reports Server (NTRS)

1973-01-01

Feasibility and cost benefits of nuclear-powered standardized spacecraft were investigated. The study indicates that two shuttle-launched nuclear-powered spacecraft should be able to serve the majority of unmanned NASA missions anticipated for the 1980's. The standard spacecraft include structure, thermal control, power, attitude control, some propulsion capability and tracking, telemetry, and command subsystems. One spacecraft design, powered by the radioisotope thermoelectric generator, can serve missions requiring up to 450 watts. The other spacecraft design, powered by similar nuclear heat sources in a Brayton-cycle generator, can serve missions requiring up to 2200 watts. Design concepts and trade-offs are discussed. The conceptual designs selected are presented and successfully tested against a variety of missions. The thermal design is such that both spacecraft are capable of operating in any earth orbit and any orientation without modification.

The orientation distribution of tunneling-related quantities

NASA Astrophysics Data System (ADS)

Seif, W. M.; Refaie, A. I.; Botros, M. M.

2018-03-01

In the nuclear tunneling processes involving deformed nuclei, most of the tunneling-related quantities depend on the relative orientations of the participating nuclei. In the presence of different multipole deformations, we study the variation of a few relevant quantities for the α-decay and the sub-barrier fusion processes, in an orientation degree of freedom. The knocking frequency and the penetration probability are evaluated within the Wentzel-Kramers-Brillouin approximation. The interaction potential is calculated with Skyrme-type nucleon-nucleon interaction. We found that the width of the potential pocket, the Coulomb barrier radius, the penetration probability, the α-decay width, and the fusion cross-section follow consistently the orientation-angle variation of the radius of the deformed nucleus. The orientation distribution patterns of the pocket width, the barrier radius, the logarithms of the penetrability, the decay width, and the fusion cross-section are found to be highly analogous to pattern of the deformed-nucleus radius. The curve patterns of the orientation angle distributions of the internal pocket depth, the Coulomb barrier height and width, as well as the knocking frequency simulate inversely the variation of the deformed nucleus radius. The predicted orientation behaviors will be of a special interest in predicting the optimum orientations for the tunneling processes.

Senior High School Students' Preference and Reasoning Modes about Nuclear Energy Use.

ERIC Educational Resources Information Center

Yang, Fang-Ying; Anderson, O. Roger

2003-01-01

Examines senior high school students' cognitive orientation toward scientific or social information, designated as information preference, and associated preferential reasoning modes when presented with an environmental issue concerning nuclear energy usage. Investigates the association of information preference variable with academic and personal…

Effect of nuclear vibrations, temperature, and orientation on injection and recombination conditions in amino-phenyl acid dyes on TiO2

NASA Astrophysics Data System (ADS)

Manzhos, Sergei; Segawa, Hiroshi; Yamashita, Koichi

2012-06-01

Adsorption geometry, nuclear vibrations, and molecular orientation of the dye with respect to the oxide surface affect significantly the performance of dye-sensitized solar cells. We compute the influence of these factors on injection and recombination conditions in organic amino-phenyl acid dyes differing by the donor group on the anatase (101) surface of titania. Nuclear motions affect significantly and differently between the dyes the driving force to injection Δ G. A temperature increase from 300 to 350 K does not have a noticeable effect on the distribution of injection rates in all studied system. Molecular dynamics simulations predict configurations in which dyes tend to lay flat on the oxide surface. The resulting proximity of the oxidation equivalent hole to the oxide is expected to promote recombination. Temporal evolution of the driving force to injection is found to be independent of dye orientation and uncorrelated to the oscillations of the Odye Ti bonds through which the dye is attached to the surface. We conclude that the dynamics of Δ G(t) is explained by uncorrelated evolution of the energies of the dye excited state and of the conduction band minimum of the oxide due to their respective vibrations. This suggests that it must be possible to control independently conditions of recombination (e.g. by preventing the dye oxidation hole from approaching TiO2 by using co-adsorbates) and of injection (e.g. by designing dyes where non-equilibrium geometries strongly destabilize dye's LUMO to increase Δ G).

On-line nuclear orientation of the deformed neutron-deficient Eu, Sm and Pm isotopes

NASA Astrophysics Data System (ADS)

Singleton, B. D. D.; Walker, P. M.; Bhagwat, A.; Al-Ghamdi, S. S.; Barham, C. G.; Grant, I. S.; Griffiths, A. G.; Rikovska, J.; Stone, N. J.

1992-11-01

Low-temperature nuclear orientation measurements made on-line at the SERC Daresbury Laboratory on142 m Eu,141 m Sm, and141Pm, with known magnetic dipole moments, have yielded the magnitude of the hyperfine fields of these isotopes in an iron host lattice. Thus measurements for the isotopes139, 138Eu,139 m Sm, and138Pm yielded values for the respective magnetic moments. Limits on the thermal relaxation times of Eu and Sm isotopes in Fe were also deduced. The results for138Eu appear to contradict the earlier πh11/2⊗νh11/2 ground-state configuration assignment.

Experimental determination of torsion angles in the polypeptide backbone of the gramicidin A channel by solid state nuclear magnetic resonance.

PubMed

Teng, Q; Nicholson, L K; Cross, T A

1991-04-05

An analytical method for the determination of torsion angles from solid state 15N nuclear magnetic resonance (n.m.r.) spectroscopic data is demonstrated. Advantage is taken of the 15N-1H and 15N-13C dipolar interactions as well as the 15N chemical shift interaction in oriented samples. The membrane-bound channel conformation of gramicidin A has eluded an atomic resolution structure determination by more traditional approaches. Here, the torsion angles for the Ala3 site are determined by obtaining the n.m.r. data for both the Gly2-Ala3 and Ala3-Leu4 peptide linkages. Complete utilization of the orientational constraints derived from these orientation-dependent nuclear spin interactions in restricting the conformational space is most effectively achieved by utilizing spherical trigonometry. Two possible sets of torsion angles for the Ala3 site are obtained (phi, psi = -129 degrees, 153 degrees and -129 degrees, 122 degrees), both of which are consistent with a right-handed beta-helix. Other functional and computational evidence strongly supports the set for which the carbonyl oxygen atom of the Ala3-Leu4 linkage is rotated into the channel lumen.

Sum frequency generation and solid-state NMR study of the structure, orientation, and dynamics of polystyrene-adsorbed peptides

PubMed Central

Weidner, Tobias; Breen, Nicholas F.; Li, Kun; Drobny, Gary P.; Castner, David G.

2010-01-01

The power of combining sum frequency generation (SFG) vibrational spectroscopy and solid-state nuclear magnetic resonance (ssNMR) spectroscopy to quantify, with site specificity and atomic resolution, the orientation and dynamics of side chains in synthetic model peptides adsorbed onto polystyrene (PS) surfaces is demonstrated in this study. Although isotopic labeling has long been used in ssNMR studies to site-specifically probe the structure and dynamics of biomolecules, the potential of SFG to probe side chain orientation in isotopically labeled surface-adsorbed peptides and proteins remains largely unexplored. The 14 amino acid leucine-lysine peptide studied in this work is known to form an α-helical secondary structure at liquid-solid interfaces. Selective, individual deuteration of the isopropyl group in each leucine residue was used to probe the orientation and dynamics of each individual leucine side chain of LKα14 adsorbed onto PS. The selective isotopic labeling methods allowed SFG analysis to determine the orientations of individual side chains in adsorbed peptides. Side chain dynamics were obtained by fitting the deuterium ssNMR line shape to specific motional models. Through the combined use of SFG and ssNMR, the dynamic trends observed for individual side chains by ssNMR have been correlated with side chain orientation relative to the PS surface as determined by SFG. This combination provides a more complete and quantitative picture of the structure, orientation, and dynamics of these surface-adsorbed peptides than could be obtained if either technique were used separately. PMID:20628016

Hydride Microstructure at the Metal-Oxide Interface of Zircaloy-4 from H.B. Robinson Nuclear Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cinbiz, Mahmut N; Edmondson, Philip D; Terrani, Kurt A

2017-01-01

This study investigates the hydride rim microstructure at the metal-oxide interface of Zircaloy-4 cladding segment removed from H.B. Robinson Nuclear Reactor by utilizing high resolution electron microscopy techniques with energy dispersive x-ray spectroscopy at Oak Ridge National Laboratory under the NSUF Rapid Turnout Experiment program. A complex stacking and orientation of hydride platelets has been observed below the sub-oxide layer. Furthermore, radial hydride platelets have been observed. EDS signals of both Fe and Cr has been reduced within hydrides whereas EDS signal of Sn is unaffected.

A new sample environment for cryogenic nuclear resonance scattering experiments on single crystals and microsamples at P01, PETRA III

NASA Astrophysics Data System (ADS)

Rackwitz, Sergej; Faus, Isabelle; Schmitz, Markus; Kelm, Harald; Krüger, Hans-Jörg; Andersson, K. Kristoffer; Hersleth, Hans-Petter; Achterhold, Klaus; Schlage, Kai; Wille, Hans-Christian; Schünemann, Volker; Wolny, Juliusz A.

2014-04-01

In order to carry out orientation dependent nuclear resonance scattering (NRS) experiments on small single crystals of e.g. iron proteins and/or chemical complexes but also on surfaces and other micrometer-sized samples a 2-circle goniometer including sample positioning optics has been installed at beamline P01, PETRA III, DESY, Hamburg. This sample environment is now available for all users of this beamline. Sample cooling is performed with a cryogenic gas stream which allows NRS measurements in the temperature range from 80 up to 400 K. In a first test this new sample environment has been used in order to investigate the orientation dependence of the nuclear inelastic scattering (NIS) signature of (i) a dinuclear iron(II) spin crossover (SCO) system and (ii) a hydrogen peroxide treated metmyoglobin single crystal.

Stabilization of the electron-nuclear spin orientation in quantum dots by the nuclear quadrupole interaction.

PubMed

Dzhioev, R I; Korenev, V L

2007-07-20

The nuclear quadrupole interaction eliminates the restrictions imposed by hyperfine interaction on the spin coherence of an electron and nuclei in a quantum dot. The strain-induced nuclear quadrupole interaction suppresses the nuclear spin flip and makes possible the zero-field dynamic nuclear polarization in self-organized InP/InGaP quantum dots. The direction of the effective nuclear magnetic field is fixed in space, thus quenching the magnetic depolarization of the electron spin in the quantum dot. The quadrupole interaction suppresses the zero-field electron spin decoherence also for the case of nonpolarized nuclei. These results provide a new vision of the role of the nuclear quadrupole interaction in nanostructures: it elongates the spin memory of the electron-nuclear system.

Stabilization of the Electron-Nuclear Spin Orientation in Quantum Dots by the Nuclear Quadrupole Interaction

NASA Astrophysics Data System (ADS)

Dzhioev, R. I.; Korenev, V. L.

2007-07-01

The nuclear quadrupole interaction eliminates the restrictions imposed by hyperfine interaction on the spin coherence of an electron and nuclei in a quantum dot. The strain-induced nuclear quadrupole interaction suppresses the nuclear spin flip and makes possible the zero-field dynamic nuclear polarization in self-organized InP/InGaP quantum dots. The direction of the effective nuclear magnetic field is fixed in space, thus quenching the magnetic depolarization of the electron spin in the quantum dot. The quadrupole interaction suppresses the zero-field electron spin decoherence also for the case of nonpolarized nuclei. These results provide a new vision of the role of the nuclear quadrupole interaction in nanostructures: it elongates the spin memory of the electron-nuclear system.

Nuclear orientation of antimony and bromine isotopes

NASA Astrophysics Data System (ADS)

Barham, Christopher G.

The technique of Low Temperature Nuclear Orientation has been used to study neutron deficient antimony and bromine isotopes. The antimony and bromine isotopes were produced using Daresbury Laboratory's Nuclear Sctructure Facility by the reactions [28]Si([93]Nb) and [28]Si([54]Fe) respectively, both at 150 MeV. Further anisotropy measurements on [72.74m,75]Br at lower temperature have been used to extend previous data. The magnetic moment of [72]Br has been limited to be within the range 0.54mu[N]

High levels of absorption in orientation-unbiased, radio-selected 3CR Active Galaxies

NASA Astrophysics Data System (ADS)

Wilkes, Belinda J.; Haas, Martin; Barthel, Peter; Leipski, Christian; Kuraszkiewicz, Joanna; Worrall, Diana; Birkinshaw, Mark; Willner, Steven P.

2014-08-01

A critical problem in understanding active galaxies (AGN) is the separation of intrinsic physical differences from observed differences that are due to orientation. Obscuration of the active nucleus is anisotropic and strongly frequency dependent leading to complex selection effects for observations in most wavebands. These can only be quantified using a sample that is sufficiently unbiased to test orientation effects. Low-frequency radio emission is one way to select a close-to orientation-unbiased sample, albeit limited to the minority of AGN with strong radio emission.Recent Chandra, Spitzer and Herschel observations combined with multi-wavelength data for a complete sample of high-redshift (1 24.2) = 2.5:1.4:1 in these high-luminosity (log L(0.3-8keV) ~ 44-46) sources. These ratios are consistent with current expectations based on modelingthe Cosmic X-ray Background. A strong correlation with radio orientation constrains the geometry of the obscuring disk/torus to have a ~60 degree opening angle and ~12 degree Compton-thick cross-section. The deduced ~50% obscured fraction of the population contrasts with typical estimates of ~20% obscured in optically- and X-ray-selected high-luminosity samples. Once the primary nuclear emission is obscured, AGN X-ray spectra are frequently dominated by unobscured non-nuclear or scattered nuclear emission which cannot be distinguished from direct nuclear emission with a lower obscuration level unless high quality data is available. As a result, both the level of obscuration and the estimated instrinsic luminosities of highly-obscured AGN are likely to be significantly (*10-1000) underestimated for 25-50% of the population. This may explain the lower obscured fractions reported for optical and X-ray samples which have no independent measure of the AGN luminosity. Correcting AGN samples for these underestimated luminosities would result in flatter derived luminosity functions and potentially change their evolution.

Determining the Orientation and Localization of Membrane-Bound Peptides

PubMed Central

Hohlweg, Walter; Kosol, Simone; Zangger, Klaus

2012-01-01

Many naturally occurring bioactive peptides bind to biological membranes. Studying and elucidating the mode of interaction is often an essential step to understand their molecular and biological functions. To obtain the complete orientation and immersion depth of such compounds in the membrane or a membrane-mimetic system, a number of methods are available, which are separated in this review into four main classes: solution NMR, solid-state NMR, EPR and other methods. Solution NMR methods include the Nuclear Overhauser Effect (NOE) between peptide and membrane signals, residual dipolar couplings and the use of paramagnetic probes, either within the membrane-mimetic or in the solvent. The vast array of solid state NMR methods to study membrane-bound peptide orientation and localization includes the anisotropic chemical shift, PISA wheels, dipolar waves, the GALA, MAOS and REDOR methods and again the use of paramagnetic additives on relaxation rates. Paramagnetic additives, with their effect on spectral linewidths, have also been used in EPR spectroscopy. Additionally, the orientation of a peptide within a membrane can be obtained by the anisotropic hyperfine tensor of a rigidly attached nitroxide label. Besides these magnetic resonance techniques a series of other methods to probe the orientation of peptides in membranes has been developed, consisting of fluorescence-, infrared- and oriented circular dichroism spectroscopy, colorimetry, interface-sensitive X-ray and neutron scattering and Quartz crystal microbalance. PMID:22044140

The relationship of bull fertility to sperm nuclear shape

USGS Publications Warehouse

Ostermeier, G.C.; Sargeant, G.A.; Yandell, B.S.; Parrish, J.J.

2001-01-01

group had a linear relationship (r .89, P .05) with fertility. To construct a plot of mean sperm shapes, a novel technique to automatically orient and identify the anterior tip of the sperm head was developed. The mean nuclear shape of high-fertility sperm was more elongated and tapered than those of lower fertility. A discriminant function (P .05) was also constructed that separated the 6 bulls into 2 groups based only on the harmonic amplitudes or sperm nuclear shape. The bulls were correctly classified into the 2 fertility groups. A comparison of sperm chromatin structure analysis (SCSA) and harmonic amplitudes found that overall size variance, anterior roundness, and posterior taperedness of sperm nuclei were related to chromatin stability (P .05). Some of the differences observed in sperm nuclear shape between the high- and lower-fertility bulls may be explained by varying levels of chromatin stability. However, sperm nuclear shape appears to contain additional information from chromatin stability alone. In this particular study, with 6 bulls, all with good chromatin quality, sperm nuclear shape was a better predictor of bull fertility.

Cognitive-emotional hyperarousal in the offspring of parents vulnerable to insomnia: a nuclear family study.

PubMed

Fernandez-Mendoza, Julio; Shaffer, Michele L; Olavarrieta-Bernardino, Sara; Vgontzas, Alexandros N; Calhoun, Susan L; Bixler, Edward O; Vela-Bueno, Antonio

2014-10-01

Cognitive-emotional hyperarousal is believed to be a predisposing factor for insomnia; however, there is limited information on the association of familial vulnerability to insomnia and cognitive-emotional hyperarousal. The aim of this study was to estimate the heritability of stress-related insomnia and examine whether parental vulnerability to stress-related insomnia is associated with cognitive-emotional hyperarousal in their offspring. We studied a volunteer sample of 135 nuclear families comprised of 270 middle-aged (51.5 ± 5.4 years) fathers and mothers and one of their biological offspring (n = 135, 20.2 ± 1.1 years). We measured vulnerability to stress-related insomnia (i.e. Ford Insomnia Response to Stress Test: FIRST), perceived stress, depression and anxiety in all participants, and arousability, presleep cognitive and somatic arousal, coping and personality in the offspring. We found a heritability estimate of 29% for FIRST scores. High FIRST parents had three to seven times the odds of having offspring highly vulnerable to stress-related insomnia. Offspring of high FIRST parents showed higher arousability, presleep cognitive arousal and emotion-oriented coping. Furthermore, high FIRST mothers contributed to offspring's higher anxiety and lower task-oriented coping, while high FIRST fathers contributed to offspring's higher presleep somatic arousal and conscientiousness. Vulnerability to stress-related insomnia is significantly heritable. Parents vulnerable to stress-related insomnia have offspring with cognitive-emotional hyperarousal who rely upon emotion-oriented coping. These data give support to the notion that arousability and maladaptive coping are key factors in the aetiology of insomnia. © 2014 European Sleep Research Society.

Nuclear weapons in the 1980s: MAD versus NUTS. Mutual hostage relationship of the superpowers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keeny, S.M. Jr.; Panofsky, W.K.H.

Critics of the strategic relationship of Mutual Assured Destruction (MAD) developed during the 1960s claim it immorally holds entire civilian populations hostage. Some advocate the Nuclear Utilization Target Selection (NUTS) concept, while others argue for a defense-oriented military posture. The interrelationships of these concepts are examined against the background of stockpiled nuclear weapons capable of massive devastation, the technical limits to defense, and the uncertainty that a nuclear war could be controlled. The evidence shows that a MAD world prevails despite NUTS proposals, which may have increased the danger by giving nuclear war the illusion of acceptability. (DCK)

Degradation studies on highly oriented poly(glycolic acid) fibres with different lamellar structures.

PubMed

de Oca, Horacio Montes; Farrar, David F; Ward, Ian M

2011-04-01

Highly oriented poly(glycolic acid) (PGA) fibres with an initial tensile strength of 1.1 GPa and different lamellar morphologies were prepared and studied during degradation in aqueous media at 37°C. A combination of small- and wide-angle X-ray scattering was used to study the structural changes during degradation and to generate two structural models of highly oriented PGA fibres with different lamellar morphologies. It is shown that as a result of crystallisation during degradation PGA crystals grow preferentially along the (110) and (020) directions of the crystal lattice or perpendicular to the orientation direction of the fibres. (1)H nuclear magnetic resonance measurements revealed three phases within the fibres with different relaxation times: (1) a mobile amorphous phase with a short relaxation time; (2) a semi-rigid phase with an intermediate relaxation time; (3) a rigid crystalline phase with a longer relaxation time. It is shown that the mobile amorphous phase degrades very rapidly and that it plays only a small role in the tensile mechanical behaviour of the fibres during degradation. It is shown that semi-rigid chains connecting crystalline domains are responsible for transferring the stress between crystalline domains and carrying the tensile deformation. It is proposed that once these tie molecules degrade considerably the oriented fibres very rapidly lose their strength retention. Copyright © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Zeeman perturbed nuclear quadrupole spin echo envelope modulations for spin 3/2 nuclei in polycrystalline specimens

NASA Astrophysics Data System (ADS)

Ramachandran, R.; Narasimhan, P. T.

The results of theoretical and experimental studies of Zeeman-perturbed nuclear quadrupole spin echo envelope modulations (ZSEEM) for spin 3/2 nuclei in polycrystalline specimens are presented. The response of the Zeeman-perturbed spin ensemble to resonant two pulse excitations has been calculated using the density matrix formalism. The theoretical calculation assumes a parallel orientation of the external r.f. and static Zeeman fields and an arbitrary orientation of these fields to the principal axes system of the electric field gradient. A numerical powder averaging procedure has been adopted to simulate the response of the polycrystalline specimens. Using a coherent pulsed nuclear quadrupole resonance spectrometer the ZSEEM patterns of the 35Cl nuclei have been recorded in polycrystalline specimens of potassium chlorate, barium chlorate, mercuric chloride (two sites) and antimony trichloride (two sites) using the π/2-τ-π/2 sequence. The theoretical and experimental ZSEEM patterns have been compared. In the case of mercuric chloride, the experimental 35Cl ZSEEM patterns are found to be nearly identical for the two sites and correspond to a near-zero value of the asymmetry parameter, η, of the electric field gradient tensor. The difference in the η values for the two 35Cl sites (η ˜0·06 and η˜0·16) in antimony trichloride is clearly reflected in the experimental and theoretical ZSEEM patterns. The present study indicates the feasibility of evaluating η for spin 3/2 nuclei in polycrystalline specimens from ZSEEM investigations.

Nuclear reactor support and seismic restraint with in-vessel core retention cooling features

DOE Office of Scientific and Technical Information (OSTI.GOV)

Edwards, Tyler A.; Edwards, Michael J.

A nuclear reactor including a lateral seismic restraint with a vertically oriented pin attached to the lower vessel head and a mating pin socket attached to the floor. Thermally insulating materials are disposed alongside the exterior surface of a lower portion of the reactor pressure vessel including at least the lower vessel head.

Working Party on International Nuclear Data Evaluation Cooperation (WPEC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dupont, E., E-mail: wpec@oecd-nea.org; Chadwick, M.B.; Danon, Y.

The OECD Nuclear Energy Agency (NEA) organizes cooperation between the major nuclear data evaluation projects in the world. The NEA Working Party on International Nuclear Data Evaluation Cooperation (WPEC) was established to promote the exchange of information on nuclear data evaluation, measurement, nuclear model calculation, validation, and related topics, and to provide a framework for cooperative activities between the participating projects. The working party assesses nuclear data improvement needs and addresses these needs by initiating joint activities in the framework of dedicated WPEC subgroups. Studies recently completed comprise a number of works related to nuclear data covariance and associated processingmore » issues, as well as more specific studies related to the resonance parameter representation in the unresolved resonance region, the gamma production from fission product capture reactions, the {sup 235}U capture cross section, the EXFOR database, and the improvement of nuclear data for advanced reactor systems. Ongoing activities focus on the evaluation of {sup 239}Pu in the resonance region, scattering angular distribution in the fast energy range, and reporting/usage of experimental data for evaluation in the resolved resonance region. New activities include two subgroups on improved fission product yield evaluation methodologies and on modern nuclear database structures. Future activities under discussion include a pilot project for a Collaborative International Evaluated Library Organization (CIELO) and methods to provide feedback from nuclear and covariance data adjustment for improvement of nuclear data. In addition to the above mentioned short-term task-oriented subgroups, WPEC also hosts a longer-term subgroup charged with reviewing and compiling the most important nuclear data requirements in a high priority request list (HPRL)« less

Working Party on International Nuclear Data Evaluation Cooperation (WPEC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giuseppe Palmiotti

The OECD Nuclear Energy Agency (NEA) is organizing the cooperation between the major nuclear data evaluation projects in the world. The NEA Working Party on International Nuclear Data Evaluation Cooperation (WPEC) was established to promote the exchange of information on nuclear data evaluation, measurement, nuclear model calculation, validation, and related topics, and to provide a framework for cooperative activities between the participating projects. The working party assesses nuclear data improvement needs and addresses these needs by initiating joint activities in the framework of dedicated WPEC subgroups. Studies recently completed comprise a number of works related to nuclear data covariance andmore » associated processing issues, as well as more specific studies related to the resonance parameter representation in the unresolved resonance region, the gamma production from fission-product capture reactions, the U-235 capture cross-section, the EXFOR database, and the improvement of nuclear data for advanced reactor systems. Ongoing activities focus on the evaluation of Pu-239 in the resonance region, scattering angular distribution in the fast energy range, and reporting/usage of experimental data for evaluation in the resolved resonance region. New activities include two new subgroups on improved fission product yield evaluation methodologies and on modern nuclear database structures. Future activities under discussion include a pilot project of a Collaborative International Evaluated Library (CIELO) and methods to provide feedback from nuclear and covariance data adjustment for improvement of nuclear data. In addition to the above mentioned short-term, task-oriented subgroups, the WPEC also hosts a longer-term subgroup charged with reviewing and compiling the most important nuclear data requirements in a high priority request list (HPRL).« less

Working Party on International Nuclear Data Evaluation Cooperation (WPEC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dupont, E.; Herman, M.; Dupont, E.

The OECD Nuclear Energy Agency (NEA) organizes cooperation between the major nuclear data evaluation projects in the world. Moreover, the NEA Working Party on International Nuclear Data Evaluation Cooperation (WPEC) was established to promote the exchange of information on nuclear data evaluation, measurement, nuclear model calculation, validation, and related topics, and to provide a framework for cooperative activities between the participating projects. The working party assesses nuclear data improvement needs and addresses these needs by initiating joint activities in the framework of dedicated WPEC subgroups. Studies recently completed comprise a number of works related to nuclear data covariance and associatedmore » processing issues, as well as more specific studies related to the resonance parameter representation in the unresolved resonance region, the gamma production from fission product capture reactions, the 235U capture cross section, the EXFOR database, and the improvement of nuclear data for advanced reactor systems. Ongoing activities focus on the evaluation of 239Pu in the resonance region, scattering angular distribution in the fast energy range, and reporting/usage of experimental data for evaluation in the resolved resonance region. New activities include two subgroups on improved fission product yield evaluation methodologies and on modern nuclear database structures. Some future activities under discussion include a pilot project for a Collaborative International Evaluated Library Organization (CIELO) and methods to provide feedback from nuclear and covariance data adjustment for improvement of nuclear data. In addition to the above mentioned short-term task-oriented subgroups, WPEC also hosts a longer-term subgroup charged with reviewing and compiling the most important nuclear data requirements in a high priority request list (HPRL).« less

Selective Optical Addressing of Nuclear Spins through Superhyperfine Interaction in Rare-Earth Doped Solids.

PubMed

Car, B; Veissier, L; Louchet-Chauvet, A; Le Gouët, J-L; Chanelière, T

2018-05-11

In Er^{3+}:Y_{2}SiO_{5}, we demonstrate the selective optical addressing of the ^{89}Y^{3+} nuclear spins through their superhyperfine coupling with the Er^{3+} electronic spins possessing large Landé g factors. We experimentally probe the electron-nuclear spin mixing with photon echo techniques and validate our model. The site-selective optical addressing of the Y^{3+} nuclear spins is designed by adjusting the magnetic field strength and orientation. This constitutes an important step towards the realization of long-lived solid-state qubits optically addressed by telecom photons.

Selective Optical Addressing of Nuclear Spins through Superhyperfine Interaction in Rare-Earth Doped Solids

NASA Astrophysics Data System (ADS)

Car, B.; Veissier, L.; Louchet-Chauvet, A.; Le Gouët, J.-L.; Chanelière, T.

2018-05-01

In Er3 +:Y2SiO5 , we demonstrate the selective optical addressing of the Y89 3 + nuclear spins through their superhyperfine coupling with the Er3 + electronic spins possessing large Landé g factors. We experimentally probe the electron-nuclear spin mixing with photon echo techniques and validate our model. The site-selective optical addressing of the Y3 + nuclear spins is designed by adjusting the magnetic field strength and orientation. This constitutes an important step towards the realization of long-lived solid-state qubits optically addressed by telecom photons.

Limited War Under the Nuclear Umbrella: An Analysis of India’s Cold Start Doctrine and Its Implications for Stability on the Subcontinent

DTIC Science & Technology

2010-06-01

theory, by creating an offensive oriented 10 Tariq M. Ashraf , “Doctrinal Reawakening of the Indian...5Cpapers23%5Cpaper2293.html (accessed July 19, 2009). 19 Ashraf , “Doctrinal Reawakening,” 58. 10 nuclear threshold emerges as one of the major constraints...20 Ashraf , “Doctrinal Reawakening,” 59. 21 Ikram Sehgal, “War-Gaming Nuclear Armageddon,” The News, 29 January 2009

Kinesin-related KIP3 of Saccharomyces cerevisiae Is Required for a Distinct Step in Nuclear Migration

PubMed Central

DeZwaan, Todd M.; Ellingson, Eric; Pellman, David; Roof, David M.

1997-01-01

Spindle orientation and nuclear migration are crucial events in cell growth and differentiation of many eukaryotes. Here we show that KIP3, the sixth and final kinesin-related gene in Saccharomyces cerevisiae, is required for migration of the nucleus to the bud site in preparation for mitosis. The position of the nucleus in the cell and the orientation of the mitotic spindle was examined by microscopy of fixed cells and by time-lapse microscopy of individual live cells. Mutations in KIP3 and in the dynein heavy chain gene defined two distinct phases of nuclear migration: a KIP3-dependent movement of the nucleus toward the incipient bud site and a dynein-dependent translocation of the nucleus through the bud neck during anaphase. Loss of KIP3 function disrupts the unidirectional movement of the nucleus toward the bud and mitotic spindle orientation, causing large oscillations in nuclear position. The oscillatory motions sometimes brought the nucleus in close proximity to the bud neck, possibly accounting for the viability of a kip3 null mutant. The kip3 null mutant exhibits normal translocation of the nucleus through the neck and normal spindle pole separation kinetics during anaphase. Simultaneous loss of KIP3 and kinesin-related KAR3 function, or of KIP3 and dynein function, is lethal but does not block any additional detectable movement. This suggests that the lethality is due to the combination of sequential and possibly overlapping defects. Epitope-tagged Kip3p localizes to astral and central spindle microtubules and is also present throughout the cytoplasm and nucleus. PMID:9281581

Neck formation and deformation effects in a preformed cluster model of exotic cluster decays

NASA Astrophysics Data System (ADS)

Kumar, Satish; Gupta, Raj K.

1997-01-01

Using the nuclear proximity approach and the two center nuclear shape parametrization, the interaction potential between two deformed and pole-to-pole oriented nuclei forming a necked configuration in the overlap region is calculated and its role is studied for the cluster decay half-lives. The barrier is found to move to a larger relative separation, with its proximity minimum lying in the neighborhood of the Q value of decay and its height and width reduced considerably. For cluster decay calculations in the preformed cluster model of Malik and Gupta, due to deformations and orientations of nuclei, the (empirical) preformation factor is found to get reduced considerably and agrees nicely with other model calculations known to be successful for their predictions of cluster decay half-lives. Comparison with the earlier case of nuclei treated as spheres suggests that the effects of both deformations and neck formation get compensated by choosing the position of cluster preformation and the inner classical turning point for penetrability calculations at the touching configuration of spherical nuclei.

NASA Growth Space Station missions and candidate nuclear/solar power systems

NASA Technical Reports Server (NTRS)

Heller, Jack A.; Nainiger, Joseph J.

1987-01-01

A brief summary is presented of a NASA study contract and in-house investigation on Growth Space Station missions and appropriate nuclear and solar space electric power systems. By the year 2000 some 300 kWe will be needed for missions and housekeeping power for a 12 to 18 person Station crew. Several Space Station configurations employing nuclear reactor power systems are discussed, including shielding requirements and power transmission schemes. Advantages of reactor power include a greatly simplified Station orientation procedure, greatly reduced occultation of views of the earth and deep space, near elimination of energy storage requirements, and significantly reduced station-keeping propellant mass due to very low drag of the reactor power system. The in-house studies of viable alternative Growth Space Station power systems showed that at 300 kWe a rigid silicon solar cell array with NiCd batteries had the highest specific mass at 275 kg/kWe, with solar Stirling the lowest at 40 kg/kWe. However, when 10 year propellant mass requirements are factored in, the 300 kWe nuclear Stirling exhibits the lowest total mass.

Seismic attenuation system for a nuclear reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liszkai, Tamas; Cadell, Seth

A system for attenuating seismic forces includes a reactor pressure vessel containing nuclear fuel and a containment vessel that houses the reactor pressure vessel. Both the reactor pressure vessel and the containment vessel include a bottom head. Additionally, the system includes a base support to contact a support surface on which the containment vessel is positioned in a substantially vertical orientation. An attenuation device is located between the bottom head of the reactor pressure vessel and the bottom head of the containment vessel. Seismic forces that travel from the base support to the reactor pressure vessel via the containment vesselmore » are attenuated by the attenuation device in a direction that is substantially lateral to the vertical orientation of the containment vessel.« less

Hospital organizational response to the nuclear accident at Three Mile Island: implications for future-oriented disaster planning.

PubMed Central

Maxwell, C

1982-01-01

The 1979 nuclear accident at Three Mile Island (TMI) near Harrisburg, Pennsylvania, caused severe organizational problems for neighboring health care institutions. Dauphin County, just north of TMI, contained four hospitals ranging in distance from 9.5 to 13.5 miles from the stricken plant. Crash plans put into effect within 48 hours of the initial incident successfully reduced hospital census to below 50 per cent of capacity, but retained bedridden and critically ill patients within the risk-zone. No plans existed for area-wide evacuation of hospitalized patients. Future-oriented disaster planning should include resource files of host institution bed capacity and transportation capabilities for the crash evacuation of hospitalized patients during non-traditional disasters. PMID:7058968

Hospital organizational response to the nuclear accident at Three Mile Island: implications for future-oriented disaster planning.

PubMed

Maxwell, C

1982-03-01

The 1979 nuclear accident at Three Mile Island (TMI) near Harrisburg, Pennsylvania, caused severe organizational problems for neighboring health care institutions. Dauphin County, just north of TMI, contained four hospitals ranging in distance from 9.5 to 13.5 miles from the stricken plant. Crash plans put into effect within 48 hours of the initial incident successfully reduced hospital census to below 50 per cent of capacity, but retained bedridden and critically ill patients within the risk-zone. No plans existed for area-wide evacuation of hospitalized patients. Future-oriented disaster planning should include resource files of host institution bed capacity and transportation capabilities for the crash evacuation of hospitalized patients during non-traditional disasters.

Reconstructing the public in old and new governance: a Korean case of nuclear energy policy.

PubMed

Kim, Hyomin

2014-04-01

Korean nuclear energy regulatory policies started to change from earlier exclusively technocratic policies into open dialogues after several anti-nuclear protests in the 1990s. However, technocratic policies still coexist with the new regulatory orientation towards openness, participation and institutional accountability. This paper analyzes Korean nuclear regulatory policies since approximately 2005 as a blend of old and new governance. The aim of the paper is not to decide whether new nuclear governance is deliberative or not by completely reviewing Korean nuclear policies after the 2000s. Instead, it provides an empirical account of how seemingly more participatory processes in decision-making entail new problems while they work with and reproduce social assumptions of different groups of the public.

MetroFission: New high-temperature references and sensors for the nuclear industry

NASA Astrophysics Data System (ADS)

Sadli, M.; del Campo, D.; de Podesta, M.; Deuzé, T.; Failleau, G.; Elliott, C. J.; Fourrez, S.; García, C.; Pearce, J. V.

2013-09-01

The European metrology research programme (EMRP) allows funding for metrology-oriented projects in the frame of targeted calls aimed at improving metrology for important contemporary and future needs in different fields such as energy, environment and industry. A joint research project (JRP), called "MetroFission", was selected for funding in the "Energy" call of 2010. This JRP, led by NPL (UK), aims to anticipate and to start addressing the metrological needs of the next generation of nuclear power plants. The need for improving the accuracy and reliability of temperature measurements at temperatures higher than those currently measured in nuclear power plants is dealt with in the first workpackage of the project. This project started in September 2010 and will last for three years. This paper summarizes the activities of the first half of the project and the expected final achievements, which will be essentially oriented towards new temperature references and new devices, adapted to the high temperature range as well as the particularly harsh working conditions.

A Dynamic/Anisotropic Low Earth Orbit (LEO) Ionizing Radiation Model

NASA Technical Reports Server (NTRS)

Badavi, Francis F.; West, Katie J.; Nealy, John E.; Wilson, John W.; Abrahms, Briana L.; Luetke, Nathan J.

2006-01-01

The International Space Station (ISS) provides the proving ground for future long duration human activities in space. Ionizing radiation measurements in ISS form the ideal tool for the experimental validation of ionizing radiation environmental models, nuclear transport code algorithms, and nuclear reaction cross sections. Indeed, prior measurements on the Space Transportation System (STS; Shuttle) have provided vital information impacting both the environmental models and the nuclear transport code development by requiring dynamic models of the Low Earth Orbit (LEO) environment. Previous studies using Computer Aided Design (CAD) models of the evolving ISS configurations with Thermo Luminescent Detector (TLD) area monitors, demonstrated that computational dosimetry requires environmental models with accurate non-isotropic as well as dynamic behavior, detailed information on rack loading, and an accurate 6 degree of freedom (DOF) description of ISS trajectory and orientation.

Packed rod neutron shield for fast nuclear reactors

DOEpatents

Eck, John E.; Kasberg, Alvin H.

1978-01-01

A fast neutron nuclear reactor including a core and a plurality of vertically oriented neutron shield assemblies surrounding the core. Each assembly includes closely packed cylindrical rods within a polygonal metallic duct. The shield assemblies are less susceptible to thermal stresses and are less massive than solid shield assemblies, and are cooled by liquid coolant flow through interstices among the rods and duct.

Introduction to Nuclear Fusion Power and the Design of Fusion Reactors. An Issue-Oriented Module.

ERIC Educational Resources Information Center

Fillo, J. A.

This three-part module focuses on the principles of nuclear fusion and on the likely nature and components of a controlled-fusion power reactor. The physical conditions for a net energy release from fusion and two approaches (magnetic and inertial confinement) which are being developed to achieve this goal are described. Safety issues associated…

Strategic perspective: Nuclear issues in the New Zealand media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fridriksson, L.N.

New Zealand's anti-nuclear policy drew international attention and threw the nation into a foreign policy crisis with the United States over the trilateral mutual security pact ANZUS. After more than a year of diminished intelligence and military cooperation, New Zealand was expelled from the alliance. This study involved a content analysis of coverage of these events and other nuclear issues in selected newspapers of New Zealand and the United States. Research points to the roles of the media as a critical one in the overall relations among countries. Through their frequent use of official government sources, the media tend tomore » uphold the government line or status quo with regard to foreign affairs. This study sought to identify the nuclear issues covered in the New Zealand and US media, the characteristics of that coverage, the sources of that coverage and how coverage varied during changing US-New Zealand relations. The official frame prevailed in coverage of nuclear issues. In the New Zealand and US newspapers under study, most sources of nuclear issue news were government officials. This research also found that most coverage of nuclear issues in the New Zealand media was related to some aspect of US interests, and that coverage of New Zealand's policy in the US media was covered most often when related to the United States. Nuclear issue coverage was most often not crisis-oriented in New Zealand and US newspapers, but coverage of all nuclear issues increased dramatically during the period of the ANZUS policy crisis. This study found a number of changes in nuclear issue coverage in the New Zealand media after the policy crisis was resolved. Among those changes were a tendency to focus less on economic and trade effects of the anti-nuclear policy, a tendency to focus more on ties with other South Pacific nations, use more sources from those countries, and a tendency to focus less on the moral and ethical position of the country.« less

Order-parameter tensor description of HPr in a medium of oriented bicelles.

PubMed

van Lune, Franciska; Manning, Linda; Dijkstra, Klaas; Berendsen, Herman J C; Scheek, Ruud M

2002-07-01

Residual dipolar couplings between 15N and 1H nuclear spins in HPr were used to determine the protein's orientation in a medium of bicelles, oriented by a magnetic field. In the case of wild-type HPr the protein's non-spherical shape can explain its orientation in this medium. In the case of the F48W mutant it was found that at least one other mechanism contributes to the observed orientation of the protein, to a degree that depends on the concentration of phosphate ions in the medium. We propose that the F48W mutant has a weak affinity towards the bicelle-surfaces that decreases with increasing phosphate concentrations. We used an order-parameter description to analyse this situation and to determine the axis of main order and the sign of the order parameter pertaining to this additional orientation mechanism.

Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome.

PubMed

Dahl, Kris Noel; Scaffidi, Paola; Islam, Mohammad F; Yodh, Arjun G; Wilson, Katherine L; Misteli, Tom

2006-07-05

The nuclear lamina is a network of structural filaments, the A and B type lamins, located at the nuclear envelope and throughout the nucleus. Lamin filaments provide the nucleus with mechanical stability and support many basic activities, including gene regulation. Mutations in LMNA, the gene encoding A type lamins, cause numerous human diseases, including the segmental premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). Here we show that structural and mechanical properties of the lamina are altered in HGPS cells. We demonstrate by live-cell imaging and biochemical analysis that lamins A and C become trapped at the nuclear periphery in HGPS patient cells. Using micropipette aspiration, we show that the lamina in HGPS cells has a significantly reduced ability to rearrange under mechanical stress. Based on polarization microscopy results, we suggest that the lamins are disordered in the healthy nuclei, whereas the lamins in HGPS nuclei form orientationally ordered microdomains. The reduced deformability of the HGPS nuclear lamina possibly could be due to the inability of these orientationally ordered microdomains to dissipate mechanical stress. Surprisingly, intact HGPS cells exhibited a degree of resistance to acute mechanical stress similar to that of cells from healthy individuals. Thus, in contrast to the nuclear fragility seen in lmna null cells, the lamina network in HGPS cells has unique mechanical properties that might contribute to disease phenotypes by affecting responses to mechanical force and misregulation of mechanosensitive gene expression.

Advanced sample environments for in situ neutron diffraction studies of nuclear materials

NASA Astrophysics Data System (ADS)

Reiche, Helmut Matthias

Generation IV nuclear reactor concepts, such as the supercritical-water-cooled nuclear reactor (SCWR), are actively researched internationally. Operating conditions above the critical point of water (374°C, 22.1 MPa) and fuel core temperature that potentially exceed 1850°C put a high demand on the surrounding materials. For their safe application, it is essential to characterize and understand the material properties on an atomic scale such as crystal structure and grain orientation (texture) changes as a function of temperature and stress. This permits the refinement of models predicting the macroscopic behavior of the material. Neutron diffraction is a powerful tool in characterizing such crystallographic properties due to their deep penetration depth into condensed matter. This leads to the ability to study bulk material properties, as opposed to surface effects, and allows for complex sample environments to study e.g. the individual contributions of thermo-mechanical processing steps during manufacturing, operating or accident scenarios. I present three sample environments for in situ neutron diffraction studies that provide such crystallographic information and have been successfully commissioned and integrated into the user program of the High Pressure -- Preferred Orientation (HIPPO) diffractometer at the Los Alamos Neutron Science Center (LANSCE) user facility. I adapted a sample changer for reliable and fast automated texture measurements of multiple specimens. I built a creep furnace combining a 2700 N load frame with a resistive vanadium furnace, capable of temperatures up to 1000°C, and manipulated by a pair of synchronized rotation stages. This combination allows following deformation and temperature dependent texture and strain evolutions in situ. Utilizing the presented sample changer and creep furnace we studied pressure tubes made of Zr-2.5wt%Nb currently employed in CANDURTM nuclear reactors and proposed for future SCWRs, acting as the primary containment vessel of high temperature heavy water (D2O) inside the reactor core. The measured sample texture shows that upon traversing the phase transition, which proceeded according to the Burger orientation relationship, variant selection occurred during heating and cooling of the zirconium alloy. Experimental results of lattice strains depending on the crystallographic orientation can be used to calculate strain pole figures which grant insight into the three-dimensional mechanical response of a polycrystalline aggregate and represent an extremely powerful material model validation tool. Lastly, I developed a resistive graphite high-temperature furnace with sample motion for in situ crystal structure and texture measurements of nuclear materials at steady-state temperatures up to at least 2200°C. This permits in situ observation of e.g. phase transitions and coefficients of thermal expansion, as well as phase formation and texture development during solidification. Utilizing this apparatus, I investigated the carbothermic reduction of UO2 nanopowder forming uranium carbide, a promising Generation IV reactor fuel. The onset of the UO2 + 2C → UC + CO2 reaction was observed at 1440°C with the bulk portion being complete at 1500°C. I describe the novel synthesis for this nanoparticle UO2 powder, which closely imitates observed nano grains in partially burnt reactor fuels. Of the three opposing structure models reported for the non-quenchable cubic UC2 phase, stable between 1769°C and 2560°C, the NaCl-type structure according to Bowman is found to be correct. This is deemed major progress as the CaF2-type structure was used for recent thermal modeling of safety critical factors in nuclear reactors. A temperature dependent increase in density due to carbon diffusion has been observed and quantified. I provide first experimental data of an unspecified, reversible order-disorder transition in this delta-phase with its onset at ˜1800°C which is likely due to rotating C2 molecules in the sublattice.

Anisotropic 2H-nuclear magnetic resonance spin-lattice relaxation in cerebroside- and phospholipid-cholesterol bilayer membranes.

PubMed

Siminovitch, D J; Ruocco, M J; Olejniczak, E T; Das Gupta, S K; Griffin, R G

1988-09-01

The axially symmetric powder pattern 2H-nuclear magnetic resonance (NMR) lineshapes observed in the liquid crystalline phase of pure lipid or lipid/cholesterol bilayers are essentially invariant to temperature, or, equivalently, to variations in the correlation times characterizing C-2H bond reorientations. In either of these melted phases, where correlation times for C-2H bond motions are shorter than 10(-7) s, information on the molecular dynamics of the saturated hydrocarbon chain would be difficult to obtain using lineshape analyses alone, and one must resort to other methods, such as the measurement of 2H spin-lattice relaxation rates, in order to obtain dynamic information. In pure lipid bilayers, the full power of the spin-lattice relaxation technique has yet to be realized, since an important piece of information, namely the orientation dependence of the 2H spin-lattice relaxation rates is usually lost due to orientational averaging of T1 by rapid lateral diffusion. Under more favorable circumstances, such as those encountered in the lipid/cholesterol mixtures of this study, the effects of orientational averaging by lateral diffusion are nullified, due to either a marked reduction (by at least an order of magnitude) in the diffusion rate, or a marked increase in the radii of curvature of the liposomes. In either case, the angular dependence of 2H spin-lattice relaxation is accessible to experimental study, and can be used to test models of molecular dynamics in these systems. Simulations of the partially recovered lineshapes indicate that the observed T1 anisotropies are consistent with large amplitude molecular reorientation of the C-2H bond among a finite number of sites. Furthermore, from the observed orientation dependence of the 2H spin-lattice relaxation rates, we conclude that order director fluctuations cannot provide the dominant relaxation pathway for acyl chain deuterons.

Orientations in adolescent use of information and communication technology: a digital divide by sociodemographic background, educational career, and health.

PubMed

Koivusilta, Leena K; Lintonen, Tomi P; Rimpelä, Arja H

2007-01-01

The role of information and communication technology (ICT) in adolescents' lives was studied, with emphasis on whether there exists a digital divide based on sociodemographic background, educational career, and health. The assumption was that some groups of adolescents use ICT more so that their information utilization skills improve (computer use), while others use it primarily for entertainment (digital gaming, contacting friends by mobile phone). Data were collected by mailed survey from a nationally representative sample of 12- to 18-year-olds (n=7,292; response 70%) in 2001 and analysed using ANOVA. Computer use was most frequent among adolescents whose fathers had higher education or socioeconomic status, who came from nuclear families, and who continued studies after compulsory education. Digital gaming was associated with poor school achievement and attending vocational rather than upper secondary school. Mobile phone use was frequent among adolescents whose fathers had lower education or socioeconomic status, who came from non-nuclear families, and whose educational prospects were poor. Intensive use of each ICT form, especially of mobile phones, was associated with health problems. High social position, nuclear family, and a successful educational career signified good health in general, independently of the diverse usage of ICT. There exists a digital divide among adolescents: orientation to computer use is more common in educated well-off families while digital gaming and mobile phone use accumulate at the opposite end of the spectrum. Poorest health was reported by mobile phone users. High social background and success at school signify better health, independently of the ways of using ICT.

Kink-bands: Shock deformation of biotite resulting from a nuclear explosion

USGS Publications Warehouse

Cummings, D.

1965-01-01

Microscopic examination of granodiorite samples from the shock region around a nuclear explosion reveals sharply folded lens-shaped zones (kink-bands) in the mineral biotite. Fifty percent of these zones are oriented approximately 90?? to the direction of shock-wave propagation, but other zones are symmetrically concentrated at shear angles of 50?? and 70?? to the direction of shock-wave propagation.

Studying Nuclear Receptor Complexes in the Cellular Environment.

PubMed

Schaufele, Fred

2016-01-01

The ligand-regulated structure and biochemistry of nuclear receptor complexes are commonly determined by in vitro studies of isolated receptors, cofactors, and their fragments. However, in the living cell, the complexes that form are governed not just by the relative affinities of isolated cofactors for the receptor but also by the cell-specific sequestration or concentration of subsets of competing or cooperating cofactors, receptors, and other effectors into distinct subcellular domains and/or their temporary diversion into other cellular activities. Most methods developed to understand nuclear receptor function in the cellular environment involve the direct tagging of the nuclear receptor or its cofactors with fluorescent proteins (FPs) and the tracking of those FP-tagged factors by fluorescence microscopy. One of those approaches, Förster resonance energy transfer (FRET) microscopy, quantifies the transfer of energy from a higher energy "donor" FP to a lower energy "acceptor" FP attached to a single protein or to interacting proteins. The amount of FRET is influenced by the ligand-induced changes in the proximities and orientations of the FPs within the tagged nuclear receptor complexes, which is an indicator of the structure of the complexes, and by the kinetics of the interaction between FP-tagged factors. Here, we provide a guide for parsing information about the structure and biochemistry of nuclear receptor complexes from FRET measurements in living cells.

White paper on nuclear astrophysics and low-energy nuclear physics, Part 2: Low-energy nuclear physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlson, Joe; Carpenter, Michael P.; Casten, Richard

In preparation for the 2015 NSAC Long Range Plan (LRP), the DNP town meetings on Nuclear Astrophysics and Low-Energy Nuclear Physics were held at the Mitchell Center on the campus of Texas A&M University August 21–23, 2014. Participants met in a number of topic-oriented working groups to discuss progress since the 2007 LRP, compelling science opportunities, and the resources needed to advance them. These considerations were used to determine priorities for the next five to ten years. In addition, approximately 270 participants attended the meetings, coming from US national laboratories, a wide range of US universities and other research institutionsmore » and universities abroad.« less

White paper on nuclear astrophysics and low-energy nuclear physics, Part 2: Low-energy nuclear physics

DOE PAGES

Carlson, Joe; Carpenter, Michael P.; Casten, Richard; ...

2017-01-04

In preparation for the 2015 NSAC Long Range Plan (LRP), the DNP town meetings on Nuclear Astrophysics and Low-Energy Nuclear Physics were held at the Mitchell Center on the campus of Texas A&M University August 21–23, 2014. Participants met in a number of topic-oriented working groups to discuss progress since the 2007 LRP, compelling science opportunities, and the resources needed to advance them. These considerations were used to determine priorities for the next five to ten years. In addition, approximately 270 participants attended the meetings, coming from US national laboratories, a wide range of US universities and other research institutionsmore » and universities abroad.« less

Dynamic nuclear spin polarization in the resonant laser excitation of an InGaAs quantum dot.

PubMed

Högele, A; Kroner, M; Latta, C; Claassen, M; Carusotto, I; Bulutay, C; Imamoglu, A

2012-05-11

Resonant optical excitation of lowest-energy excitonic transitions in self-assembled quantum dots leads to nuclear spin polarization that is qualitatively different from the well-known optical orientation phenomena. By carrying out a comprehensive set of experiments, we demonstrate that nuclear spin polarization manifests itself in quantum dots subjected to finite external magnetic field as locking of the higher energy Zeeman transition to the driving laser field, as well as the avoidance of the resonance condition for the lower energy Zeeman branch. We interpret our findings on the basis of dynamic nuclear spin polarization originating from noncollinear hyperfine interaction and find excellent agreement between experiment and theory. Our results provide evidence for the significance of noncollinear hyperfine processes not only for nuclear spin diffusion and decay, but also for buildup dynamics of nuclear spin polarization in a coupled electron-nuclear spin system.

Room-temperature in situ nuclear spin hyperpolarization from optically pumped nitrogen vacancy centres in diamond

DOE PAGES

King, Jonathan P.; Jeong, Keunhong; Vassiliou, Christophoros C.; ...

2015-12-07

Low detection sensitivity stemming from the weak polarization of nuclear spins is a primary limitation of magnetic resonance spectroscopy and imaging. Methods have been developed to enhance nuclear spin polarization but they typically require high magnetic fields, cryogenic temperatures or sample transfer between magnets. Here we report bulk, room-temperature hyperpolarization of 13C nuclear spins observed via high-field magnetic resonance. The technique harnesses the high optically induced spin polarization of diamond nitrogen vacancy centres at room temperature in combination with dynamic nuclear polarization. We observe bulk nuclear spin polarization of 6%, an enhancement of ~170,000 over thermal equilibrium. The signal ofmore » the hyperpolarized spins was detected in situ with a standard nuclear magnetic resonance probe without the need for sample shuttling or precise crystal orientation. In conclusion, hyperpolarization via optical pumping/dynamic nuclear polarization should function at arbitrary magnetic fields enabling orders of magnitude sensitivity enhancement for nuclear magnetic resonance of solids and liquids under ambient conditions.« less

Psychotherapist countertransference in the nuclear age: Effects on therapeutic interventions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oderberg, N.A.

Since the early 1980s, there has been considerable attention in the psychology literature to mental health problems related to living in a world threatened by nuclear destruction. Questionnaires were mailed to 630 psychotherapists from the Colorado Psychological Association, California Psychotherapists for Social Responsibility, California Psychologists for Social Responsibility, the US Army, and the APA Division of Military Psychology; 174 questionnaires were returned. It was hypothesized that liberalism, nuclear weapons opposition, nuclear concern, nuclear awareness, and anti-nuclear activism in psychotherapists would facilitate perception of, and openness to working with, a client's nuclear concerns and thus, would be positively correlated with intentionsmore » to discuss nuclear issues with clients in three different clinical vignettes. Results indicated that when controlling for subject group, psychotherapy orientation, age, sex, and income, all five independent variables were positively correlated with responses to all three clinical vignettes, with nuclear concern having the strongest unique effect in accounting for variance in responses to the vignettes.« less

SLK-dependent activation of ERMs controls LGN–NuMA localization and spindle orientation

PubMed Central

Machicoane, Mickael; de Frutos, Cristina A.; Fink, Jenny; Rocancourt, Murielle; Lombardi, Yannis; Garel, Sonia; Piel, Matthieu

2014-01-01

Mitotic spindle orientation relies on a complex dialog between the spindle microtubules and the cell cortex, in which F-actin has been recently implicated. Here, we report that the membrane–actin linkers ezrin/radixin/moesin (ERMs) are strongly and directly activated by the Ste20-like kinase at mitotic entry in mammalian cells. Using microfabricated adhesive substrates to control the axis of cell division, we found that the activation of ERMs plays a key role in guiding the orientation of the mitotic spindle. Accordingly, impairing ERM activation in apical progenitors of the mouse embryonic neocortex severely disturbed spindle orientation in vivo. At the molecular level, ERM activation promotes the polarized association at the mitotic cortex of leucine-glycine-asparagine repeat protein (LGN) and nuclear mitotic apparatus (NuMA) protein, two essential factors for spindle orientation. We propose that activated ERMs, together with Gαi, are critical for the correct localization of LGN–NuMA force generator complexes and hence for proper spindle orientation. PMID:24958772

Visualisation of collagen fibrils in joint cartilage using STIM

NASA Astrophysics Data System (ADS)

Reinert, T.; Reibetanz, U.; Vogt, J.; Butz, T.; Werner, A.; Gründer, W.

2001-07-01

The scanning transmission ion microscopy (STIM) method was used to investigate the collagen network structure of the articular cartilage from a pig's knee in comparison with high resolution nuclear magnetic resonance imaging (microscopic NMR-tomography) and polarised light microscopy (PLM). Single collagen fibrils down to 200 nm in diameter were visualised. It was proved that the cartilage collagen network consists partly of zones of oriented fibrils as suggested by NMR measurements. Radially oriented fibrils were found in the zone near the calcified zone (hypertrophic zone) of both tibia and femur, and in the tibial radial zone. Tangentially oriented fibrils were found in the femoral and tibial superficial zone and in a second zone of the femoral cartilage. Polarisation light microscopy reveals broader zones of orientation than it was found with STIM.

Rapid, portable detection of endocrine disrupting chemicals through ligand-nuclear hormone receptor interactions.

PubMed

Hunt, J Porter; Schinn, Song-Min; Jones, Matthew D; Bundy, Bradley C

2017-12-04

Endocrine disrupting chemicals (EDC) are structurally diverse compounds that can interact with nuclear hormone receptors, posing significant risk to human and ecological health. Unfortunately, many conventional biosensors have been too structure-specific, labor-intensive or laboratory-oriented to detect broad ranges of EDC effectively. Recently, several technological advances are providing more rapid, portable, and affordable detection of endocrine-disrupting activity through ligand-nuclear hormone receptor interactions. Here, we overview these recent advances applied to EDC biosensors - including cell lyophilization, cell immobilization, cell-free systems, smartphone-based signal detection, and improved competitive binding assays.

Spin disorder in maghemite nanoparticles investigated using polarized neutrons and nuclear resonant scattering

NASA Astrophysics Data System (ADS)

Herlitschke, M.; Disch, S.; Sergueev, I.; Schlage, K.; Wetterskog, E.; Bergström, L.; Hermann, R. P.

2016-04-01

The manuscript reports the investigation of spin disorder in maghemite nanoparticles of different shape by a combination of polarized small-angle neutron scattering (SANSPOL) and nuclear forward scattering (NFS) techniques. Both methods are sensitive to magnetization on the nanoscale. SANSPOL allows for investigation of the particle morphology and spatial magnetization distribution and NFS extends this nanoscale information to the atomic scale, namely the orientation of the hyperfine field experienced by the iron nuclei. The studied nanospheres and nanocubes with diameters of 7.4 nm and 10.6 nm, respectively, exhibit a significant spin disorder. This effect leads to a reduction of the magnetization to 44% and 58% of the theoretical maghemite bulk value, observed consistently by both techniques.

Pulsed electron nuclear double resonance studies of the photoexcited triplet state of pentacene in p-terphenyl crystals at room temperature.

PubMed

Yago, Tomoaki; Link, Gerhard; Kothe, Gerd; Lin, Tien-Sung

2007-09-21

Pulsed electron nuclear double resonance (ENDOR) using a modified Davies-type [Phys. Lett. 47A, 1 (1974)] sequence is employed to study the hyperfine (HF) structure of the photoexcited triplet state of pentacene dispersed in protonated and deuterated p-terphenyl single crystals. The strong electron spin polarization and long phase memory time of triplet pentacene enable us to perform the ENDOR measurements on the S=1 spin system at room temperature. Proton HF tensor elements and spin density values of triplet pentacene are extracted from a detailed angular-dependent study in which the orientation of the magnetic field is varied systematically in two different pentacene planes. Analysis reveals that the pentacene molecule is no longer planar in the p-terphenyl host lattice. The distortion is more pronounced in the deuterated crystal where the unit cell dimensions are slightly smaller than those of the protonated crystal.

Nuclear Spin relaxation mediated by Fermi-edge electrons in n-type GaAs

NASA Astrophysics Data System (ADS)

Kotur, M.; Dzhioev, R. I.; Kavokin, K. V.; Korenev, V. L.; Namozov, B. R.; Pak, P. E.; Kusrayev, Yu. G.

2014-03-01

A method based on the optical orientation technique was developed to measure the nuclear-spin lattice relaxation time T 1 in semiconductors. It was applied to bulk n-type GaAs, where T 1 was measured after switching off the optical excitation in magnetic fields from 400 to 1200 G at low (< 30 K) temperatures. The spin-lattice relaxation of nuclei in the studied sample with n D = 9 × 1016 cm-3 was found to be determined by hyperfine scattering of itinerant electrons (Korringa mechanism) which predicts invariability of T 1 with the change in magnetic field and linear dependence of the relaxation rate on temperature. This result extends the experimentally verified applicability of the Korringa relaxation law in degenerate semiconductors, previously studied in strong magnetic fields (several Tesla), to the moderate field range.

The ENSDF Java Package

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sonzogni, A.A.

2005-05-24

A package of computer codes has been developed to process and display nuclear structure and decay data stored in the ENSDF (Evaluated Nuclear Structure Data File) library. The codes were written in an object-oriented fashion using the java language. This allows for an easy implementation across multiple platforms as well as deployment on web pages. The structure of the different java classes that make up the package is discussed as well as several different implementations.

Nuclear magnetic resonance of Al-27 in topaz, Al2SiO4/F, OH/2.

NASA Technical Reports Server (NTRS)

Tsang, T.; Ghose, S.

1972-01-01

The Al-27 nuclear quadrupolar coupling constant and asymmetry parameter (eta) in topaz have been determined to be 1.67 (plus or minus 0.03) MHz and 0.38 plus or minus 0.05, respectively. These values and the orientations of the principal axes are consistent with the Fe(3+) paramagnetic resonance data and with the symmetry of the AlO4F2 octahedron.

NUCLEAR REACTORS

DOEpatents

Long, E.; Ashby, J.W.

1958-09-16

ABS>A graphite moderator structure is presented for a nuclear reactor compriscd of an assembly of similarly orientated prismatic graphite blocks arranged on spaced longitudinal axes lying in common planes wherein the planes of the walls of the blocks are positioned so as to be twisted reintive to the planes of said axes so thatthe unlmpeded dtrect paths in direction wholly across the walls of the blocks are limited to the width of the blocks plus spacing between the blocks.

Conformational study of 13C-enriched fibroin in the solid state, using the cross polarization nuclear magnetic resonance method.

PubMed

Fujiwara, T; Kobayashi, Y; Kyogoku, Y; Kataoka, K

1986-01-05

Silk fibroin with the alanyl carboxyl carbon enriched with 13C was obtained by giving a diet containing 13C-enriched alanine to the larvae of Bombyx mori and Antheraea pernyi at the fifth instar. Sericin-free fibroin fibers were prepared from cocoons, and gut was made from the liquid silk in the gland. The final 13C content was about 13%. Cross polarization/magic angle sample spinning spectra at 25 MHz and 75 MHz were measured for each sample at different orientations. Spectra were simulated using the principal values and orientations of the shielding tensor in the alanine crystal. The results indicate that the beta-structure of the fibroin may be a little more flattened than the typical pleated sheet beta-structure.

Micronuclei and other erythrocyte nuclear abnormalities in fishes from the Great Lakes Basin, USA

USGS Publications Warehouse

Braham, Ryan P.; Blazer, Vicki S.; Shaw, Cassidy H.; Mazik, Patricia M.

2017-01-01

Biological markers (biomarkers) sensitive to genotoxic and mutagenic contamination in fishes are widely used to identify exposure effects in aquatic environments. The micronucleus assay was incorporated into a suite of indicators to assess exposure to genotoxic and mutagenic contamination at five Great Lakes Areas of Concern (AOCs), as well as one non-AOC (reference) site. The assay allowed enumeration of micronuclei as well as other nuclear abnormalities for both site and species comparisons. Erythrocyte abnormality data was also compared to skin and liver tumor prevalence and hepatic transcript abundance. Erythrocyte abnormalities were observed at all sites with variable occurrence and severity among sites and species. Benthic-oriented brown bullhead (Ameiurus nebulosus) and white sucker (Catostomus commersonii) expressed lower rates of erythrocyte abnormalities, but higher rates of skin and liver neoplasms, when compared to pelagic-oriented largemouth bass (Micropterus salmoides) or smallmouth bass (Micropterus dolomieu) at the same site. The reduced erythrocyte abnormalities, increased transcript abundance associated with Phase I and II toxicant responsive pathways, and increased neoplastic lesions among benthic-oriented taxa may indicate the development of contaminant resistance of these species to more acute effects.

Understanding the molecular aspects of oriental obesity pattern differentiation using DNA microarray.

PubMed

Hong, Sun Woo; Yoo, Jae-Wook; Bose, Shambhunath; Park, Jung-Hyun; Han, Kyungsun; Kim, Soyoun; Lim, Chi-Yeon; Kim, Hojun; Lee, Dong-Ki

2015-10-19

Human constitution, the fundamental basis of oriental medicine, is categorized into different patterns for a particular disease according to the physical, physiological, and clinical characteristics of the individuals. Obesity, a condition of metabolic disorder, is classified according to six patterns in oriental medicine, as follows: spleen deficiency syndrome, phlegm fluid syndrome, yang deficiency syndrome (YDS), food accumulation syndrome (FAS), liver depression syndrome (LDS), and blood stasis syndrome. In oriental medicine, identification of the disease pattern for individual obese patients is performed on the basis of differentiation in obesity syndrome index and, accordingly, personalized treatment is provided to the patients. The aim of the current study was to understand the obesity patterns in oriental medicine from the genomic point of view via determining the gene expression signature of obese patients using peripheral blood mononuclear cells as the samples. The study was conducted in 23 South Korean obese subjects (19 female and four male) with BMI ≥25 kg/m(2). Identification of oriental obesity pattern was based on the software-guided evaluation of the responses of the subjects to a questionnaire developed by the Korean Institute of Oriental Medicine. The expression profiles of genes were determined using DNA microarray and the level of transcription of genes of interest was further evaluated using quantitative real-time PCR (qRT-PCR). Gene clustering analysis of the microarray data from the FAS, LDS, and YDS subjects exhibited disease pattern-specific upregulation of expression of several genes in a particular cluster. Further analysis of transcription of selected genes using qRT-PCR led to identification of specific genes, including prostaglandin endoperoxide synthase 2, G0/G1 switch 2, carcinoembryonic antigen-related cell adhesion molecule 3, cystein-serine-rich nuclear protein 1, and interleukin 8 receptor, alpha which were highly expressed in LDS obesity constitution. Our current study can be considered as a valuable contribution to the understanding of possible explanation for obesity pattern differentiation in oriental medicine. Further studies can address a novel possibility that the genomic and oriental empirical approaches can be combined and implemented in systematic and synergistic development of personalized medicine. This clinical trial was registered in Clinical Research Information Service of Korea National Institute of Health ( https://cris.nih.go.kr/cris/index.jsp ). KCT0000387.

The Role of SncN and Ski in Mammary Epithelial Cell Transformation

DTIC Science & Technology

2005-07-01

cellular activities through the Smad proteins. Upon phosphorylation by the active TGFβ receptor kinases, Smad2 and Smad3 oligomerize with Smad4, translocate...sequence in sense and antisense orientation with an intervening linker . Primer pairs were designed to generate single-strand overhangs upon annealing...nuclear protein, based on studies of ectopically expressed SnoN and endogenous SnoN in cancer cell lines. In the nucleus, SnoN binds to Smad2, Smad3 , and

Experimental test of the polarization direction correlation method (PDCO)

NASA Astrophysics Data System (ADS)

Starosta, K.; Morek, T.; Droste, Ch.; Rohoziński, S. G.; Srebrny, J.; Wierzchucka, A.; Bergström, M.; Herskind, B.; Melby, E.; Czosnyka, T.; Napiorkowski, P. J.

1999-02-01

The study of the polarization direction correlation method (PDCO) for γ quanta emitted from the nuclear states oriented in fusion-evaporation reactions is discussed with emphasis on making unique multipolarity assignments. The method is applied to the data coming from a typical experiment performed with the EUROGAM II array, where polarization-sensitive CLOVER detectors were used. The accuracy obtained in the experiment for the studied transitions was high enough to exclude, using the PDCO method, most of the ambiguities which occur if the assignments are made on the basis of angular correlation measurements alone.

Effect of microstructure on the corrosion of CVD-SiC exposed to supercritical water

NASA Astrophysics Data System (ADS)

Tan, L.; Allen, T. R.; Barringer, E.

2009-10-01

Silicon carbide (SiC) is an important engineering material being studied for potential use in multiple nuclear energy systems including high-temperature gas-cooled reactors and water-cooled reactors. The corrosion behavior of SiC exposed to supercritical water (SCW) is critical for examining its applications in nuclear reactors. Although the hydrothermal corrosion of SiC has been the subject of many investigations, the study on the microstructural effects on the corrosion is limited. This paper presents the effect of residual strain, grain size, grain boundary types, and surface orientations on the corrosion of chemical vapor deposited (CVD) β-SiC exposed to SCW at 500 °C and 25 MPa. Weight loss occurred on all the samples due to localized corrosion. Residual strains associated with small grains showed the most significant effect on the corrosion compared to the other factors.

Risk Analysis as Regulatory Science: Toward The Establishment of Standards

PubMed Central

Murakami, Michio

2016-01-01

Understanding how to establish standards is essential for risk communication and also provides perspectives for further study. In this paper, the concept of risk analysis as regulatory science for the establishment of standards is demonstrated through examples of standards for evacuation and provisional regulation values in foods and drinking water. Moreover, academic needs for further studies related to standards are extracted. The concepts of the traditional ‘Standard I’, which has a paternalistic orientation, and ‘Standard II’, established through stakeholder consensus, are then systemized by introducing the current status of the new standards-related movement that developed after the Fukushima nuclear power plant accident, and the perspectives of the standards are discussed. Preparation of standards on the basis of stakeholder consensus through intensive risk dialogue before a potential nuclear power plant accident is suggested to be a promising approach to ensure a safe society and enhance subjective well-being. PMID:27475751

Risk Analysis as Regulatory Science: Toward The Establishment of Standards.

PubMed

Murakami, Michio

2016-09-01

Understanding how to establish standards is essential for risk communication and also provides perspectives for further study. In this paper, the concept of risk analysis as regulatory science for the establishment of standards is demonstrated through examples of standards for evacuation and provisional regulation values in foods and drinking water. Moreover, academic needs for further studies related to standards are extracted. The concepts of the traditional 'Standard I', which has a paternalistic orientation, and 'Standard II', established through stakeholder consensus, are then systemized by introducing the current status of the new standards-related movement that developed after the Fukushima nuclear power plant accident, and the perspectives of the standards are discussed. Preparation of standards on the basis of stakeholder consensus through intensive risk dialogue before a potential nuclear power plant accident is suggested to be a promising approach to ensure a safe society and enhance subjective well-being. © The Author 2016. Published by Oxford University Press.

Spin disorder in maghemite nanoparticles investigated using polarized neutrons and nuclear resonant scattering

DOE PAGES

Herlitschke, Marcus; Disch, Sabrina; Sergueev, I.; ...

2016-05-11

The manuscript reports the investigation of spin disorder in maghemite nanoparticles of different shape by a combination of polarized small-angle neutron scattering (SANSPOL) and nuclear forward scattering (NFS) techniques. Both methods are sensitive to magnetization on the nanoscale. SANSPOL allows for investigation of the particle morphology and spatial magnetization distribution and NFS extends this nanoscale information to the atomic scale, namely the orientation of the hyperfine field experienced by the iron nuclei. The studied nanospheres and nanocubes with diameters of 7.4nm and 10.6 nm, respectively, exhibit a significant spin disorder. This effect leads to a reduction of the magnetization tomore » 44% and 58% of the theoretical maghemite bulk value, observed consistently by both techniques.« less

Spin coherent states phenomena probed by quantum state tomography in Zeeman perturbed nuclear quadrupole resonance

NASA Astrophysics Data System (ADS)

Teles, João; Auccaise, Ruben; Rivera-Ascona, Christian; Araujo-Ferreira, Arthur G.; Andreeta, José P.; Bonagamba, Tito J.

2018-07-01

Recently, we reported an experimental implementation of quantum information processing (QIP) by nuclear quadrupole resonance (NQR). In this work, we present the first quantum state tomography (QST) experimental implementation in the NQR QIP context. Two approaches are proposed, employing coherence selection by temporal and spatial averaging. Conditions for reduction in the number of cycling steps are analyzed, which can be helpful for larger spin systems. The QST method was applied to the study of spin coherent states, where the alignment-to-orientation phenomenon and the evolution of squeezed spin states show the effect of the nonlinear quadrupole interaction intrinsic to the NQR system. The quantum operations were implemented using a single-crystal sample of KClO3 and observing ^{35}Cl nuclei, which posses spin 3/2.

Spin disorder in maghemite nanoparticles investigated using polarized neutrons and nuclear resonant scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herlitschke, Marcus; Disch, Sabrina; Sergueev, I.

The manuscript reports the investigation of spin disorder in maghemite nanoparticles of different shape by a combination of polarized small-angle neutron scattering (SANSPOL) and nuclear forward scattering (NFS) techniques. Both methods are sensitive to magnetization on the nanoscale. SANSPOL allows for investigation of the particle morphology and spatial magnetization distribution and NFS extends this nanoscale information to the atomic scale, namely the orientation of the hyperfine field experienced by the iron nuclei. The studied nanospheres and nanocubes with diameters of 7.4nm and 10.6 nm, respectively, exhibit a significant spin disorder. This effect leads to a reduction of the magnetization tomore » 44% and 58% of the theoretical maghemite bulk value, observed consistently by both techniques.« less

Energy in perspective: an orientation conference for educators. [28 presentations

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKlveen, J.W.

An awareness of energy and the pertinent economic, environmental, and risk/benefit consideration must be presented to the public. A logical beginning point is in the classroom, through knowledgeable and motivated educators. Ms. Carolyn Warner, Superintendent of Public Instruction, State of Arizona, presented the first paper, Energy and the Educator. Papers on all aspects of energy were presented at the conference by experts from throughout the United States. The papers were: Energy Resources: World and U.S.A.; Coal Technology: Mining, Energy Generation, Wastes, and Environmental Considerations; Energy Conservation; Arizona's Energy Resources and Development; Gas and Oil: Natural Gas, S.N.G., Oil, Oil Shale,more » and Tar Sands; Geothermal Energy Perspective; Solar Energy; Solar Technology; Natural Radiation Environment; Fission Theory; Arizona's Palo Verde Nuclear Generation Complex; Gas Cooled Reactors, Liquid Metal Reactors and Alternatives; Radioactive Wastes: Disposal Alternatives; Reactor Safety; Nuclear Safeguards; Fusion Power; Genetic and Somatic Radiation Effects; Energy Economics; Religion, Philosophy, and Energy; Nuclear Studies in Fine Arts and Archeology; Nuclear Methods Applied to Agriculture and Food Preservation; Nuclear Methods in Criminology; Environmental Impact of Energy Generation; and Risk and Insurance Consideration--Energy for Tomorrow. The tours to energy installations conducted during the conference and demonstration related to energy are cited. (MCW)« less

Newly discovered geological features and their potential impact on Darlington and Pickering. Report No. INFO-0342

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wallach, J.L.

1990-01-01

The design basis seismic ground motion for the nuclear generating stations at Darlington and at Pickering were determined solely through the assessment of previous earthquakes with no geological, or any other geophysical, input. Since then geophysical maps, showing a north-northwest oriented linear feature with some possible associated seismic activity, were examined. This report discusses the impact of these new discoveries on the Darlington and Pickering nuclear generating stations and on the already known geophysical features of the area.

The Nature of Russia’s Threat to NATO’s Enhanced Forward Presence in the Baltic States

DTIC Science & Technology

2017-12-01

Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) N /A...OOB order of battle OODA observe, orient, decide, act OSCE Organization for Security and Cooperation in Europe OSK Joint Strategic Command OSK- N ...Russia’s Nuclear Threats,” 7–9; Shamanov, “Non-nuclear Forces.” 9 Roger N . McDermott, Brothers Disunited: Russia’s Use of Military Power in Ukraine (Ft

Exploration for fossil and nuclear fuels from orbital altitudes. [results of ERTS program for oil exploration

NASA Technical Reports Server (NTRS)

Short, N. M.

1974-01-01

Results from the ERTS program pertinent to exploration for oil, gas, and uranium are discussed. A review of achievements in relevant geological studies from ERTS, and a survey of accomplishments oriented towards exploration for energy sources are presented along with an evaluation of the prospects and limitations of the space platform approach to fuel exploration, and an examination of continuing programs designed to prove out the use of ERTS and other space system in exploring for fuel resources.

Study of heavy-ion induced fission for heavy-element synthesis

NASA Astrophysics Data System (ADS)

Nishio, K.; Ikezoe, H.; Hofmann, S.; Heßberger, F. P.; Ackermann, D.; Antalic, S.; Aritomo, Y.; Comas, V. F.; Düllman, Ch. E.; Gorshkov, A.; Graeger, R.; Heinz, S.; Heredia, J. A.; Hirose, K.; Khuyagbaatar, J.; Kindler, B.; Kojouharov, I.; Lommel, B.; Makii, H.; Mann, R.; Mitsuoka, S.; Nagame, Y.; Nishinaka, I.; Ohtsuki, T.; Popeko, A. G.; Saro, S.; Schädel, M.; Türler, A.; Wakabayashi, Y.; Watanabe, Y.; Yakushev, A.; Yeremin, A. V.

2014-03-01

Fission fragment mass distributions were measured in heavy-ion induced fissions using 238U target nucleus. The measured mass distributions changed drastically with incident energy. The results are explained by a change of the ratio between fusion and qasifission with nuclear orientation. A calculation based on a fluctuation dissipation model reproduced the mass distributions and their incident energy dependence. Fusion probability was determined in the analysis, and the values were consistent with those determined from the evaporation residue cross sections.

System modeling with the DISC framework: evidence from safety-critical domains.

PubMed

Reiman, Teemu; Pietikäinen, Elina; Oedewald, Pia; Gotcheva, Nadezhda

2012-01-01

The objective of this paper is to illustrate the development and application of the Design for Integrated Safety Culture (DISC) framework for system modeling by evaluating organizational potential for safety in nuclear and healthcare domains. The DISC framework includes criteria for good safety culture and a description of functions that the organization needs to implement in order to orient the organization toward the criteria. Three case studies will be used to illustrate the utilization of the DISC framework in practice.

Strategic Studies Quarterly, Volume 4, Number 3, Fall 2010

DTIC Science & Technology

2010-01-01

Story of the Aum Doomsday Cult, from the Subways of Tokyo to the Nuclear Arsenals of Russia (New York: Crown Publishers, 1996 ), 108-12. 32. Lt Col John...Attraction," Journal of Personality andSocial Psychology󈨊, no. 2 (February 1996 ). 26. As Siebold and Lindsay put it, "A central tenet of current [1999...Ralph M. Carney, eds., Out in Force: Sexual Orientation and the Miliuiry (Chicago: University of Chicago Press, 1996 ), 166. 29. Om Prakash, "The

Nanotopographical Modulation of Cell Function through Nuclear Deformation

PubMed Central

Wang, Kai; Bruce, Allison; Mezan, Ryan; Kadiyala, Anand; Wang, Liying; Dawson, Jeremy; Rojanasakul, Yon; Yang, Yong

2016-01-01

Although nanotopography has been shown to be a potent modulator of cell behavior, it is unclear how the nanotopographical cue, through focal adhesions, affects the nucleus, eventually influencing cell phenotype and function. Thus, current methods to apply nanotopography to regulate cell behavior are basically empirical. We, herein, engineered nanotopographies of various shapes (gratings and pillars) and dimensions (feature size, spacing and height), and thoroughly investigated cell spreading, focal adhesion organization and nuclear deformation of human primary fibroblasts as the model cell grown on the nanotopographies. We examined the correlation between nuclear deformation and cell functions such as cell proliferation, transfection and extracellular matrix protein type I collagen production. It was found that the nanoscale gratings and pillars could facilitate focal adhesion elongation by providing anchoring sites, and the nanogratings could orient focal adhesions and nuclei along the nanograting direction, depending on not only the feature size but also the spacing of the nanogratings. Compared with continuous nanogratings, discrete nanopillars tended to disrupt the formation and growth of focal adhesions and thus had less profound effects on nuclear deformation. Notably, nuclear volume could be effectively modulated by the height of nanotopography. Further, we demonstrated that cell proliferation, transfection, and type I collagen production were strongly associated with the nuclear volume, indicating that the nucleus serves as a critical mechanosensor for cell regulation. Our study delineated the relationships between focal adhesions, nucleus and cell function and highlighted that the nanotopography could regulate cell phenotype and function by modulating nuclear deformation. This study provides insight into the rational design of nanotopography for new biomaterials and the cell–substrate interfaces of implants and medical devices. PMID:26844365

Transmutation of Radioactive Nuclear Waste — Present Status and Requirement for the Problem-Oriented Nuclear Database: Approach to Scheduling the Experiments (Reactor, Target, Blanket)

NASA Astrophysics Data System (ADS)

Artisyuk, V.; Ignatyuk, A.; Korovin, Yu.; Lopatkin, A.; Matveenko, I.; Stankovskiy, A.; Titarenko, Yu.

2005-05-01

Transmutation of nuclear wastes (Minor Actinides and Long-Lived Fission Products) remains an important option to reduce the burden of high-level waste on final waste disposal in deep geological structures. Accelerator-Driven Systems (ADS) are considered as possible candidates to perform transmutation due to their subcritical operation mode that eliminates some of the serious safety penalties unavoidable in critical reactors. Specific requirements to nuclear data necessary for ADS transmutation analysis is the main subject of the ISTC Project ♯2578 which started in 2004 to identify the areas of research priorities in the future. The present paper gives a summary of ongoing project stressing the importance of nuclear data for blanket performance (reactivity behavior with associated safety characteristics) and uncertainties that affect characteristics of neutron producing target.

Operations Nougat and Whetstone events: Hard Hat, Danny Boy, Marshmallow, Mudpack, Wishbone, Gumdrop, Diluted Waters, and Tiny Tot, 15 February 1962-17 June 1965. Final report 15 Feb 62-19 Jun 68

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brady, W.J.; Horton, K.K.; Eubank, B.F.

1984-01-31

This report is a personnel oriented history of DOD participation in underground nuclear weapons testing during Operations NOUGAT and WHETSTONE, test events HARD HAT, DANNY BOY, MARSHMALLOW, MUDPACK, WISHBONE, GUMDROP, DILUTED WATERS, and TINY TOT. It is the first in a series of historical reports which will include all DOD underground nuclear weapons tests and DOE underground nuclear weapons tests with significant DOD participation from 1962 forward. In addition to these volumes presenting a history of the underground nuclear test program, a later restricted volume will identify all DOD participants, (military, civilian, and their contractors) and will list their dosimetrymore » data.« less

Modern NMR Spectroscopy.

ERIC Educational Resources Information Center

Jelinski, Lynn W.

1984-01-01

Discusses direct chemical information that can be obtained from modern nuclear magnetic resonance (NMR) methods, concentrating on the types of problems that can be solved. Shows how selected methods provide information about polymers, bipolymers, biochemistry, small organic molecules, inorganic compounds, and compounds oriented in a magnetic…

The Keller Plan: A Successful Experiment in Engineering Education.

ERIC Educational Resources Information Center

Koen, Billy; And Others

1985-01-01

Discusses the Keller Plan or personalized system of instruction (PSI), a mastery-oriented, self-paced, modular teaching strategy using student/peer proctors. Success for PSI in chemical engineering, operations research, electrical engineering, and nuclear engineering courses is explained. (DH)

Box C/D sRNA stem ends act as stabilizing anchors for box C/D di-sRNPs

PubMed Central

Yip, W. S. Vincent; Shigematsu, Hideki; Taylor, David W.; Baserga, Susan J.

2016-01-01

Ribosomal RNA (rRNA) modifications are essential for ribosome function in all cellular organisms. Box C/D small (nucleolar) ribonucleoproteins [s(no)RNPs] catalyze 2′-O-methylation, one rRNA modification type in Eukarya and Archaea. Negatively stained electron microscopy (EM) models of archaeal box C/D sRNPs have demonstrated the dimeric sRNP (di-sRNP) architecture, which has been corroborated by nuclear magnetic resonance (NMR) studies. Due to limitations of the structural techniques, the orientation of the box C/D sRNAs has remained unclear. Here, we have used cryo-EM to elucidate the sRNA orientation in a M. jannaschii box C/D di-sRNP. The cryo-EM reconstruction suggests a parallel orientation of the two sRNAs. Biochemical and structural analyses of sRNPs assembled with mutant sRNAs indicate a potential interaction between the sRNA stem ends. Our results suggest that the parallel arrangement of the sRNAs juxtaposes their stem ends into close proximity to allow for a stabilizing interaction that helps maintain the di-sRNP architecture. PMID:27342279

Influence of crystal orientation and ion bombardment on the nitrogen diffusivity in single-crystalline austenitic stainless steel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martinavicius, A.; Abrasonis, G.; Moeller, W.

2011-10-01

The nitrogen diffusivity in single-crystalline AISI 316L austenitic stainless steel (ASS) during ion nitriding has been investigated at different crystal orientations ((001), (110), (111)) under variations of ion flux (0.3-0.7 mA cm{sup -2}), ion energy (0.5-1.2 keV), and temperature (370-430 deg. C). The nitrogen depth profiles obtained from nuclear reaction analysis are in excellent agreement with fits using the model of diffusion under the influence of traps, from which diffusion coefficients were extracted. At fixed ion energy and flux, the diffusivity varies by a factor up to 2.5 at different crystal orientations. At (100) orientation, it increases linearly with increasingmore » ion flux or energy. The findings are discussed on the basis of atomistic mechanisms of interstitial diffusion, potential lattice distortions, local decomposition, and ion-induced lattice vibrational excitations.« less

Nuclear magnetic relaxation induced by exchange-mediated orientational randomization: longitudinal relaxation dispersion for spin I = 1.

PubMed

Nilsson, Tomas; Halle, Bertil

2012-08-07

The frequency dependence of the longitudinal relaxation rate, known as the magnetic relaxation dispersion (MRD), can provide a frequency-resolved characterization of molecular motions in complex biological and colloidal systems on time scales ranging from 1 ns to 100 μs. The conformational dynamics of immobilized proteins and other biopolymers can thus be probed in vitro or in vivo by exploiting internal water molecules or labile hydrogens that exchange with a dominant bulk water pool. Numerous water (1)H and (2)H MRD studies of such systems have been reported, but the widely different theoretical models currently used to analyze the MRD data have resulted in divergent views of the underlying molecular motions. We have argued that the essential mechanism responsible for the main dispersion is the exchange-mediated orientational randomization (EMOR) of anisotropic nuclear (electric quadrupole or magnetic dipole) couplings when internal water molecules or labile hydrogens escape from orientationally confining macromolecular sites. In the EMOR model, the exchange process is thus not just a means of mixing spin populations but it is also the direct cause of spin relaxation. Although the EMOR theory has been used in several studies to analyze water (2)H MRD data from immobilized biopolymers, the fully developed theory has not been described. Here, we present a comprehensive account of a generalized version of the EMOR theory for spin I = 1 nuclides like (2)H. As compared to a previously described version of the EMOR theory, the present version incorporates three generalizations that are all essential in applications to experimental data: (i) a biaxial (residual) electric field gradient tensor, (ii) direct and indirect effects of internal motions, and (iii) multiple sites with different exchange rates. In addition, we describe and assess different approximations to the exact EMOR theory that are useful in various regimes. In particular, we consider the experimentally important dilute regime, for which approximate analytical results are derived. As shown by the analytical expressions, and confirmed by exact numerical calculations, the dispersion is governed by the pure nuclear quadrupole resonance frequencies in the ultraslow-motion regime, where the relaxation rate also exhibits a much stronger dependence on the electric field gradient asymmetry than in the motional-narrowing regime.

Nuclear magnetic relaxation induced by exchange-mediated orientational randomization: longitudinal relaxation dispersion for a dipole-coupled spin-1/2 pair.

PubMed

Chang, Zhiwei; Halle, Bertil

2013-10-14

In complex biological or colloidal samples, magnetic relaxation dispersion (MRD) experiments using the field-cycling technique can characterize molecular motions on time scales ranging from nanoseconds to microseconds, provided that a rigorous theory of nuclear spin relaxation is available. In gels, cross-linked proteins, and biological tissues, where an immobilized macromolecular component coexists with a mobile solvent phase, nuclear spins residing in solvent (or cosolvent) species relax predominantly via exchange-mediated orientational randomization (EMOR) of anisotropic nuclear (electric quadrupole or magnetic dipole) couplings. The physical or chemical exchange processes that dominate the MRD typically occur on a time scale of microseconds or longer, where the conventional perturbation theory of spin relaxation breaks down. There is thus a need for a more general relaxation theory. Such a theory, based on the stochastic Liouville equation (SLE) for the EMOR mechanism, is available for a single quadrupolar spin I = 1. Here, we present the corresponding theory for a dipole-coupled spin-1/2 pair. To our knowledge, this is the first treatment of dipolar MRD outside the motional-narrowing regime. Based on an analytical solution of the spatial part of the SLE, we show how the integral longitudinal relaxation rate can be computed efficiently. Both like and unlike spins, with selective or non-selective excitation, are treated. For the experimentally important dilute regime, where only a small fraction of the spin pairs are immobilized, we obtain simple analytical expressions for the auto-relaxation and cross-relaxation rates which generalize the well-known Solomon equations. These generalized results will be useful in biophysical studies, e.g., of intermittent protein dynamics. In addition, they represent a first step towards a rigorous theory of water (1)H relaxation in biological tissues, which is a prerequisite for unravelling the molecular basis of soft-tissue contrast in clinical magnetic resonance imaging.

Limited period of graviresponsiveness in germinating spores of Ceratopteris richardii

NASA Technical Reports Server (NTRS)

Edwards, E. S.; Roux, S. J.

1994-01-01

Rhizoids of the fern Ceratopteris richardii Brogn. usually emerge 40 h after germination is initiated by light, and more than 90% of them emerge growing in a downward direction. However, when the spores are germinated on a clinostat, the emerging rhizoids show no preferential orientation. This indicates that under normal 1 g conditions the initial growth direction of rhizoids can be oriented by gravity. If the orientation of the spores is changed 3 h or less after the start of germination, the growth direction of most emerging rhizoids becomes downward relative to the new orientation. However, if the orientation of the spores is changed by 180 degrees 8 h or more after germination is initiated by light, most rhizoids emerge growing upward; i.e., the same direction as if there had been no orientation change. Emerged rhizoids also do not change their direction of growth if their orientation is changed. These results indicate that the growth direction of emerging rhizoids is set by gravity prior to actual emergence, and that the time of full orientation responsiveness is limited to a period ranging from the initiation of germination to about 3-4 h after the start of germination. There is a gravity-oriented nuclear movement beginning at about 13 h after germination, and this movement appears to predict the initial growth direction of rhizoids.

Limited period of graviresponsiveness in germinating spores of Ceratopteris richardii.

PubMed

Edwards, E S; Roux, S J

1994-01-01

Rhizoids of the fern Ceratopteris richardii Brogn. usually emerge 40 h after germination is initiated by light, and more than 90% of them emerge growing in a downward direction. However, when the spores are germinated on a clinostat, the emerging rhizoids show no preferential orientation. This indicates that under normal 1 g conditions the initial growth direction of rhizoids can be oriented by gravity. If the orientation of the spores is changed 3 h or less after the start of germination, the growth direction of most emerging rhizoids becomes downward relative to the new orientation. However, if the orientation of the spores is changed by 180 degrees 8 h or more after germination is initiated by light, most rhizoids emerge growing upward; i.e., the same direction as if there had been no orientation change. Emerged rhizoids also do not change their direction of growth if their orientation is changed. These results indicate that the growth direction of emerging rhizoids is set by gravity prior to actual emergence, and that the time of full orientation responsiveness is limited to a period ranging from the initiation of germination to about 3-4 h after the start of germination. There is a gravity-oriented nuclear movement beginning at about 13 h after germination, and this movement appears to predict the initial growth direction of rhizoids.

A special method for analyzing anisotropic nuclear magnetic resonance parameters: Acetonitrile in liquid crystals

NASA Astrophysics Data System (ADS)

Lounila, Juhani; Ala-Korpela, Mika; Jokisaari, Jukka

1990-12-01

A reliable analysis of the nuclear magnetic resonance (NMR) spectral parameters of partially oriented molecules requires the calculation of the effects of the correlation between the molecular vibration and rotation. However, in many cases the information content of the spectral data is not sufficient for an unambiguous determination of all the adjustable parameters involved in such an analysis. The present paper describes a special method to simplify the analysis significantly, so as to make seemingly underdetermined problems solvable. The method is applicable to the molecules which contain segments composed of one or more light bonds attached to a heavier bond. It is applied to the anisotropic couplings Dij of acetonitrile (CH3CN) oriented in various liquid crystals. The analysis leads to the following rα geometry: ∠HCH=109.22°±0.06°, rCH/rCC =0.751±0.002 and rCN/rCC =0.788±0.005. In addition, detailed information on (1) the indirect coupling anisotropies ΔJCC and 2ΔJCN, (2) the 1H and 13C chemical shift anisotropies, (3) the external torques acting on the CH bonds, and (4) the orientational order parameters of the CH3C segment of the acetonitrile molecule is obtained.

Integrated head package cable carrier for a nuclear power plant

DOEpatents

Meuschke, Robert E.; Trombola, Daniel M.

1995-01-01

A cabling arrangement is provided for a nuclear reactor located within a containment. Structure inside the containment is characterized by a wall having a near side surrounding the reactor vessel defining a cavity, an operating deck outside the cavity, a sub-space below the deck and on a far side of the wall spaced from the near side, and an operating area above the deck. The arrangement includes a movable frame supporting a plurality of cables extending through the frame, each connectable at a first end to a head package on the reactor vessel and each having a second end located in the sub-space. The frame is movable, with the cables, between a first position during normal operation of the reactor when the cables are connected to the head package, located outside the sub-space proximate the head package, and a second position during refueling when the cables are disconnected from the head package, located in the sub-space. In a preferred embodiment, the frame straddles the top of the wall in a substantially horizontal orientation in the first position, pivots about an end distal from the head package to a substantially vertically oriented intermediate position, and is guided, while remaining about vertically oriented, along a track in the sub-space to the second position.

Electron tomography of the microtubule cytoskeleton in multinucleated hyphae of Ashbya gossypii.

PubMed

Gibeaux, Romain; Lang, Claudia; Politi, Antonio Z; Jaspersen, Sue L; Philippsen, Peter; Antony, Claude

2012-12-01

We report the mechanistic basis guiding the migration pattern of multiple nuclei in hyphae of Ashbya gossypii. Using electron tomography, we reconstructed the cytoplasmic microtubule (cMT) cytoskeleton in three tip regions with a total of 13 nuclei and also the spindle microtubules of four mitotic nuclei. Each spindle pole body (SPB) nucleates three cMTs and most cMTs above a certain length grow according to their plus-end structure. Long cMTs closely align for several microns along the cortex, presumably marking regions where dynein generates pulling forces on nuclei. Close proximity between cMTs emanating from adjacent nuclei was not observed. The majority of nuclei carry duplicated side-by-side SPBs, which together emanate an average of six cMTs, in most cases in opposite orientation with respect to the hyphal growth axis. Such cMT arrays explain why many nuclei undergo short-range back and forth movements. Only occasionally do all six cMTs orient in one direction, a precondition for long-range nuclear bypassing. Following mitosis, daughter nuclei carry a single SPB with three cMTs. The increased probability that all three cMTs orient in one direction explains the high rate of nuclear bypassing observed in these nuclei. The A. gossypii mitotic spindle was found to be structurally similar to that of Saccharomyces cerevisiae in terms of nuclear microtubule (nMT) number, length distribution and three-dimensional organization even though the two organisms differ significantly in chromosome number. Our results suggest that two nMTs attach to each kinetochore in A. gossypii and not only one nMT like in S. cerevisiae.

How to think about nuclear war

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luttwak, E.N.

1982-08-01

Mr. Luttwak, a professional defense consultant, observes the arguments of nuclear freeze proponents can be refuted on both strategic and moral grounds. The freeze concept is illogical, he notes, because it is political systems - not state boundaries - that separate sides and because the Warsaw Pact countries are more heavily armed than the North Atlantic Treaty Organization (NATO) countries. An important factor keeping NATO forces at a disadvantage is their defensive orientation, which keeps forces militarily diffuse and dependent on nuclear weapons and preemptive action as a deterrent. Mr. Luttwak feels the shock effect of any use of nuclearmore » weapons would probably shorten a war rather than expand it because of the instinct for survival on both sides; further only nuclear weapons have this awesome power to deter. The proposal for universal disarmament under world government control is not a serious one, he thinks, and reflects an indifference to the possibility of a long non-nuclear war. The effect would be to trade the risk of nuclear death for the inevitability of many non-nuclear casualties. (DCK)« less

Module-oriented modeling of reactive transport with HYTEC

NASA Astrophysics Data System (ADS)

van der Lee, Jan; De Windt, Laurent; Lagneau, Vincent; Goblet, Patrick

2003-04-01

The paper introduces HYTEC, a coupled reactive transport code currently used for groundwater pollution studies, safety assessment of nuclear waste disposals, geochemical studies and interpretation of laboratory column experiments. Based on a known permeability field, HYTEC evaluates the groundwater flow paths, and simulates the migration of mobile matter (ions, organics, colloids) subject to geochemical reactions. The code forms part of a module-oriented structure which facilitates maintenance and improves coding flexibility. In particular, using the geochemical module CHESS as a common denominator for several reactive transport models significantly facilitates the development of new geochemical features which become automatically available to all models. A first example shows how the model can be used to assess migration of uranium from a sub-surface source under the effect of an oxidation front. The model also accounts for alteration of hydrodynamic parameters (local porosity, permeability) due to precipitation and dissolution of mineral phases, which potentially modifies the migration properties in general. The second example illustrates this feature.

Low-energy nuclear reactions in crystal structures

NASA Astrophysics Data System (ADS)

Bagulya, A. V.; Dalkarov, O. D.; Negodaev, M. A.; Rusetskii, A. S.

2017-09-01

Results of studying low-energy nuclear reactions at the HELIS facility (LPI) are presented. Investigations of yields from DD reactions in deuterated crystal structures at deuteron energies of 10 to 25 keV show a considerable enhancement effect. It is shown that exposure of the deuterated targets to the H+ (proton) and Ne+ beams with energies from 10 to 25 keV and an X-ray beam with the energy of 20 to 30 keV stimulates DD reaction yields. For the CVD diamond target, it is shown that its orientation with respect to the deuteron beam affects the neutron yield. The D+ beam is shown to cause much higher heat release in the TiDx target than the H+ and Ne+ beams, and this heat release depends on the deuterium concentration in the target and the current density of the deuteron beam.

Nuclear resonance tomography with a toroid cavity detector

DOEpatents

Woelk, K.; Rathke, J.W.; Klingler, R.J.

1996-11-12

A toroid cavity detection system is described for determining the spectral properties and distance from a fixed point for a sample using Nuclear Magnetic Resonance. The detection system consists of a toroid with a central conductor oriented along the main axis of the toroidal cylinder and perpendicular to a static uniform magnetic field oriented along the main axis of the toroid. An rf signal is input to the central conductor to produce a magnetic field perpendicular to the central axis of the toroid and whose field strength varies as the inverse of the radius of the toroid. The toroid cavity detection system can be used to encapsulate a sample, or the detection system can be perforated to allow a sample to flow into the detection device or to place the samples in specified sample tubes. The central conductor can also be coated to determine the spectral property of the coating and the coating thickness. The sample is then subjected to the respective magnetic fields and the responses measured to determine the desired properties. 4 figs.

Nuclear resonance tomography with a toroid cavity detector

DOEpatents

Woelk, Klaus; Rathke, Jerome W.; Klingler, Robert J.

1996-01-01

A toroid cavity detection system for determining the spectral properties and distance from a fixed point for a sample using Nuclear Magnetic Resonance. The detection system consists of a toroid with a central conductor oriented along the main axis of the toroidal cylinder and perpendicular to a static uniform magnetic field oriented along the main axis of the toroid. An rf signal is inputted to the central conductor to produce a magnetic field perpendicular to the central axis of the toroid and whose field strength varies as the inverse of the radius of the toroid. The toroid cavity detection system can be used to encapsulate a sample, or the detection system can be perforated to allow a sample to flow into the detection device or to place the samples in specified sample tubes. The central conductor can also be coated to determine the spectral property of the coating and the coating thickness. The sample is then subjected to the respective magnetic fields and the responses measured to determine the desired properties.

Nuclear magnetic resonance studies on yeast tRNAPhe. II. Assignment of the iminoproton resonances of the anticodon and T stem by means of nuclear Overhauser effect experiments at 500 MHz.

PubMed Central

Heerschap, A; Haasnoot, C A; Hilbers, C W

1983-01-01

Resonances of the water exchangeable iminoprotons of the T and anticodon stem of yeast tRNAPhe were assigned by means of Nuclear Overhauser Effects (NOE's). Together with our previous assignments of iminoproton resonances from the acceptor and D stem (A. Heerschap, C.A.G. Haasnoot and C.W. Hilbers (1982) Nucleic Acids Res. 10, 6981-7000) the present results constitute a complete assignment of all resonances of iminoprotons involved in the secondary structure of yeast tRNAPhe with a reliability and spectral resolution not reached heretofore. Separate identification of the methylprotons in m5C40 and m5C49 was also possible due to specific NOE patterns in the lowfield part of the spectrum. Our experiments indicate that in solution the psi 39 residue in the anticodon stem is orientated in a syn conformation in contrast to the normally observed anti orientation of the uracil base in AU basepairs. Evidence is presented that in solution the acceptor stem is stacked upon the T stem. Furthermore, it turns out that in a similar way the anticodon stem forms a continuous stack with the D stem, but here the m2(2)G26 residue is located between the latter two stems (as is found in the X-ray crystal structure). The stacking of these stems is not strictly dependent on the presence of magnesium ions. NOE experiments show that these structural features are preserved when proceeding from a buffer with magnesium ions to a buffer without magnesium ions although differences in chemical shifts and NOE intensities indicate changes in the conformation of the tRNA. PMID:6346268

Orientation Uncertainty of Structures Measured in Cored Boreholes: Methodology and Case Study of Swedish Crystalline Rock

NASA Astrophysics Data System (ADS)

Stigsson, Martin

2016-11-01

Many engineering applications in fractured crystalline rocks use measured orientations of structures such as rock contact and fractures, and lineated objects such as foliation and rock stress, mapped in boreholes as their foundation. Despite that these measurements are afflicted with uncertainties, very few attempts to quantify their magnitudes and effects on the inferred orientations have been reported. Only relying on the specification of tool imprecision may considerably underestimate the actual uncertainty space. The present work identifies nine sources of uncertainties, develops inference models of their magnitudes, and points out possible implications for the inference on orientation models and thereby effects on downstream models. The uncertainty analysis in this work builds on a unique data set from site investigations, performed by the Swedish Nuclear Fuel and Waste Management Co. (SKB). During these investigations, more than 70 boreholes with a maximum depth of 1 km were drilled in crystalline rock with a cumulative length of more than 34 km including almost 200,000 single fracture intercepts. The work presented, hence, relies on orientation of fractures. However, the techniques to infer the magnitude of orientation uncertainty may be applied to all types of structures and lineated objects in boreholes. The uncertainties are not solely detrimental, but can be valuable, provided that the reason for their presence is properly understood and the magnitudes correctly inferred. The main findings of this work are as follows: (1) knowledge of the orientation uncertainty is crucial in order to be able to infer correct orientation model and parameters coupled to the fracture sets; (2) it is important to perform multiple measurements to be able to infer the actual uncertainty instead of relying on the theoretical uncertainty provided by the manufacturers; (3) it is important to use the most appropriate tool for the prevailing circumstances; and (4) the single most important parameter to decrease the uncertainty space is to avoid drilling steeper than about -80°.

The alternative strategies of the development of the nuclear power industry in the 21st century

NASA Astrophysics Data System (ADS)

Goverdovskii, A. A.; Kalyakin, S. G.; Rachkov, V. I.

2014-05-01

This paper emphasizes the urgency of scientific-and-technical and sociopolitical problems of the modern nuclear power industry without solving of which the transition from local nuclear power systems now in operation to a large-scale nuclear power industry would be impossible. The existing concepts of the longterm strategy of the development of the nuclear power industry have been analyzed. On the basis of the scenarios having been developed it was shown that the most promising alternative is the orientation towards the closed nuclear fuel cycle with fast neutron reactors (hereinafter referred to as fast reactors) that would meet the requirements on the acceptable safety. It was concluded that the main provisions of "The Strategy of the Development of the Nuclear Power Industry of Russia for the First Half of the 21st Century" approved by the Government of the Russian Federation in the year 2000 remain the same at present as well, although they require to be elaborated with due regard for new realities in the market for fossil fuels, the state of both the Russian and the world economy, as well as tightening of requirements related to safe operation of nuclear power stations (NPSs) (for example, after the severe accident at the Fukushima nuclear power station, Japan) and nonproliferation of nuclear weapons.

Peptide backbone orientation and dynamics in spider dragline silk and two-photon excitation in nuclear magnetic and quadrupole resonance

NASA Astrophysics Data System (ADS)

Eles, Philip Thomas

2005-07-01

In the first part of the dissertation, spider dragline silk is studied by solid state NMR techniques. The dependence of NMR frequency on molecular orientation is exploited using the DECODER experiment to determine the orientation of the protein backbone within the silk fibre. Practical experimental considerations require that the silk fibres be wound about a cylindrical axis perpendicular to the external magnetic field, complicating the reconstruction of the underlying orientation distribution and necess-itating the development of numerical techniques for this purpose. A two-component model of silk incorporating static b-sheets and polyglycine II helices adequately fits the NMR data and suggests that the b-sheets are well aligned along the silk axis (20 FWHM) while the helices are poorly aligned (68 FWHM). The effects of fibre strain, draw rate and hydration on orientation are measured. Measurements of the time-scale for peptide backbone motion indicate that when wet, a strain-dependent frac-tion of the poorly aligned component becomes mobile. This suggests a mechanism for the supercontraction of silk involving latent entropic springs that undergo a local strain-dependent phase transition, driving supercontraction. In the second part of this dissertation a novel method is developed for exciting NMR and nuclear quadrupole resonance (NQR) by rf irradiation at multiple frequencies that sum to (or differ by) the resonance frequency. This is fundamentally different than traditional NMR experiments where irradiation is applied on-resonance. With excitation outside the detection bandwidth, two-photon excitation allows for detection of free induction signals during excitation, completely eliminating receiver dead-time. A theoretical approach to describing two-photon excitation is developed based on average Hamiltonian theory. An intuition for two-photon excitation is gained by analogy to the coherent absorption of multiple photons requiring conservation of total energy and momentum. It is shown that two-photon excitation efficiency impro-ves when the two applied rf frequencies deviate from half-resonance. For two-photon NQR, it is shown that observable magnetization appears perpendicular to the excita-tion coil, requiring a second coil for detection, and that double quantum coherences are also generated. Several model systems and experimental geometries are used to demonstrate the peculiarities of two-photon excitation in NMR and NQR.

Framing political messages to fit the audience's regulatory orientation: how to improve the efficacy of the same message content.

PubMed

Mannetti, Lucia; Brizi, Ambra; Giacomantonio, Mauro; Higgins, E Tory

2013-01-01

This research investigates how the impact of persuasive messages in the political domain can be improved when fit is created by subliminally priming recipients' regulatory focus (either promotion or prevention) and by linguistic framing of the message (either strategic approach framing or strategic avoidance framing). Results of two studies show that regulatory fit: a) increases the impact of a political message favoring nuclear energy on implicit attitudes of the target audience (Study 1); and b) induces a more positive evaluation of, and intentions to vote for, the political candidate who is delivering a message concerning immigration policies (Study 2).

GIS Modelling of Radionuclide Transport from the Semipalatinsk Test Site

NASA Astrophysics Data System (ADS)

Balakay, L.; Zakarin, E.; Mahura, A.; Baklanov, A.; Sorensen, J. H.

2009-04-01

In this study, the software complex GIS-project MigRad (Migration of Radionuclide) was developed, tested and applied for the territory of the Semipalatinsk test site/ polygon (Republic of Kazakhstan), where since 1961, in total 348 underground nuclear explosions were conducted. The MigRad is oriented on integration of large volumes of different information (mapping, ground-based, and satellite-based survey): and also includes modeling on its base local redistribution of radionuclides by precipitation and surface waters and by long-range transport of radioactive aerosols. The existing thermal anomaly on territory of the polygon was investigated in details, and the object-oriented analysis was applied for the studied area. Employing the RUNOFF model, the simulation of radionuclides migration with surface waters was performed. Employing the DERMA model, the simulation of long-term atmospheric transport, dispersion and deposition patterns for cesium was conducted from 3 selected locations (Balapan, Delegen, and Experimental Field). Employing geoinformation technology, the mapping of the of the high temperature zones and epicenters of radioactive aerosols transport for the territory of the test site was carried out with post-processing and integration of modelling results into GIS environment. Contamination levels of pollution due to former nuclear explosions for population and environment of the surrounding polygon territories of Kazakhstan as well as adjacent countries were analyzed and evaluated. The MigRad was designed as instrument for comprehensive analysis of complex territorial processes influenced by former nuclear explosions on the territory of Semipalatinsk test site. It provides possibilities in detailed analyses for (i) extensive cartographic material, remote sensing, and field measurements data collected in different level databases; (ii) radionuclide migration with flows using accumulation and redistribution of soil particles; (iii) thermal anomalies caused by explosions and observed on the test site and adjacent territories, and (iv) long-range transport of radioactive aerosols with analysis of dynamics of spatial distribution, averaged and accumulated fields for concentration and deposition patterns.

Heme orientational disorder in human adult hemoglobin reconstituted with a ring fluorinated heme and its functional consequences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagao, Satoshi; Hirai, Yueki; Kawano, Shin

2007-03-16

A ring fluorinated heme, 13,17-bis(2-carboxylatoethyl)-3,8-diethyl-2-fluoro-7,12, 18-trimethyl-porphyrin-atoiron(III), has been incorporated into human adult hemoglobin (Hb A). The heme orientational disorder in the individual subunits of the protein has been readily characterized using {sup 19}F NMR and the O{sub 2} binding properties of the protein have been evaluated through the oxygen equilibrium analysis. The equilibrated orientations of hemes in {alpha}- and {beta}- subunits of the reconstituted protein were found to be almost completely opposite to each other, and hence were largely different from those of the native and the previously reported reconstituted proteins [T. Jue, G.N. La Mar, Heme orientational heterogeneity inmore » deuterohemin-reconstituted horse and human hemoglobin characterized by proton nuclear magnetic resonance spectroscopy, Biochem. Biophys. Res. Commun. 119 (1984) 640-645]. Despite the large difference in the degree of the heme orientational disorder in the subunits of the proteins, the O{sub 2} affinity and the cooperativity of the protein reconstituted with 2-MF were similar to those of the proteins reconstituted with a series of hemes chemically modified at the heme 3- and 8-positions [K. Kawabe, K. Imaizumi, Z. Yoshida, K. Imai, I. Tyuma, Studies on reconstituted myoglobins and hemoglobins II. Role of the heme side chains in the oxygenation of hemoglobin, J. Biochem. 92 (1982) 1713-1722], whose O{sub 2} affinity and cooperativity were higher and lower, respectively, relative to those of native protein. These results indicated that the heme orientational disorder could exert little effect, if any, on the O{sub 2} affinity properties of Hb A. This finding provides new insights into structure-function relationship of Hb A.« less

Brainstem efferents from the interface between the nucleus medialis and the nucleus interpositus in the rat.

PubMed

Buisseret-Delmas, C; Angaut, P; Compoint, C; Diagne, M; Buisseret, P

1998-12-14

In a previous report (Buisseret-Delmas et al. [1993] Neurosci. Res. 16:195-207), the authors identified the interface between the cerebellar nuclei medialis and interpositus as the origin of the nuclear output from cortical zone X. They named this nuclear interface the interstitial cell group (icg). In this study, the authors analyzed the icg efferents to the brainstem by using the anterograde and retrograde tracer biotinylated dextran amine. The main targets of these efferents are from rostral to caudal: 1) the accessory oculomotor nuclear region, essentially, the interstitial nucleus of Cajal; 2) the caudoventral region of the red nucleus; 3) a dorsal zone of the nucleus reticularis tegmenti pontis; 4) restricted regions of the four main vestibular nuclei; and 5) three restricted areas in the inferior olive, one that is caudal in the medial accessory subnucleus and two others that are rostral and caudal in the dorsal accessory subnucleus, respectively. These data support the notion that the icg contributes to the control of gaze-orientation mechanisms, particularly those that are related to the vestibuloocular reflex.

Cytomorphological effects of mitomycin C on urothelial cells: eosinophils may be clue to the drug-induced changes.

PubMed

Guler Simsek, Gulcin; Vargol, Erdem; Simsek, Hulya

2014-01-01

Cytomorphological changes of mitomycin C on urothelial cells may be misinterpreted as a neoplastic process. A 60-year old male patient who was given an eight-week course of intravesical mitomycin C due to non-invasive low grade transitional cell carcinoma. During his follow-up care, the findings of a urine cytology exam were as follows: nuclear enlargement of cells, wrinkled nuclear membranes, little hyperchromasia, pleomorphism, abnormal nuclear morphology and disordered orientation of the urothelium. Furthermore, there were eosinophils nearby the atypical cells. This report aimed at reminding the cytomorphologic changes of mitomycin C may be misinterpreted as carcinoma, so the presence of eosinophils is required to predict the drug-induced changes.

PET Mapping for Brain-Computer Interface Stimulation of the Ventroposterior Medial Nucleus of the Thalamus in Rats with Implanted Electrodes.

PubMed

Zhu, Yunqi; Xu, Kedi; Xu, Caiyun; Zhang, Jiacheng; Ji, Jianfeng; Zheng, Xiaoxiang; Zhang, Hong; Tian, Mei

2016-07-01

Brain-computer interface (BCI) technology has great potential for improving the quality of life for neurologic patients. This study aimed to use PET mapping for BCI-based stimulation in a rat model with electrodes implanted in the ventroposterior medial (VPM) nucleus of the thalamus. PET imaging studies were conducted before and after stimulation of the right VPM. Stimulation induced significant orienting performance. (18)F-FDG uptake increased significantly in the paraventricular thalamic nucleus, septohippocampal nucleus, olfactory bulb, left crus II of the ansiform lobule of the cerebellum, and bilaterally in the lateral septum, amygdala, piriform cortex, endopiriform nucleus, and insular cortex, but it decreased in the right secondary visual cortex, right simple lobule of the cerebellum, and bilaterally in the somatosensory cortex. This study demonstrated that PET mapping after VPM stimulation can identify specific brain regions associated with orienting performance. PET molecular imaging may be an important approach for BCI-based research and its clinical applications. © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Follicular morphological characteristics may be associated with invasion in follicular thyroid neoplasms with papillary-like nuclear features.

PubMed

Can, Nuray; Celik, Mehmet; Sezer, Yavuz Atakan; Ozyilmaz, Filiz; Ayturk, Semra; Tastekin, Ebru; Sut, Necdet; Gurkan, Hakan; Ustun, Funda; Bulbul, Buket Yilmaz; Guldiken, Sibel; Puyan, Fulya Oz

2017-08-20

The newly proposed nomenclature and diagnostic criteria for encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), the noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), could improve the consistency and accuracy of diagnosing this entity. Diagnosis of NIFTP requires evaluation of the complete tumor border or capsule. The presence of tumor invasion in follicular thyroid neoplasms with papillary-like nuclear features has been recently discussed by many authors. In this study, we examined the predictive value and association of follicular morphological characteristics with the tumor invasion. In addition, we analyzed the association between tumor encapsulation and molecular profile in EFVPTC/NIFTP cases. A total of 106 cases of FVPTC were included in the study. The tumors were grouped based on the presence of tumor capsule and characteristics of tumor border, as 1) completely encapsulated tumors without invasion, 2) encapsulated tumors with invasion, 3) infiltrative tumors without a capsule. Clinicopathological features, histomorphological features [nuclear criteria, minor diagnostic features, follicles oriented perpendicular to tumor border/capsule (FOPBC)] and molecular alterations in BRAF, NRAS, and KRAS genes were evaluated. FOPBC were significantly more frequently seen in encapsulated tumors with invasion (p = 0.008). The nuclear features were not associated with the presence of encapsulation and characteristics of tumor border. BRAF mutation was more frequent in infiltrative tumors, while NRAS mutation was more frequent in encapsulated tumors, but the results were not statistically significant (p = 0.917). In conclusion, FOPBC histomorphological feature may be associated with tumor invasion in EFVPTC/NIFTP. Additionally, BRAF/KRAS/NRAS mutation analysis may prevent inadequate treatment in these patients.

A Course in Natural Science and National Security in the Nuclear Age.

ERIC Educational Resources Information Center

Blumberg, Avrom A.

1983-01-01

Topics and instructional strategies for an upper-level, problem-oriented science and society course at De Paul University are described. Objectives and grading procedures for "Problems in Modern Warfare, Arms Control, and Disarmament" are also described. Course syllabus, bibliography, and sample quizzes/examinations are available from…

J-resistance curves for Inconel 690 and Incoloy 800 nuclear steam generators tubes at room temperature and at 300 °C

NASA Astrophysics Data System (ADS)

Bergant, Marcos A.; Yawny, Alejandro A.; Perez Ipiña, Juan E.

2017-04-01

The structural integrity of steam generator tubes is a relevant issue concerning nuclear plant safety. In the present work, J-resistance curves of Inconel 690 and Incoloy 800 nuclear steam generator tubes with circumferential and longitudinal through wall cracks were obtained at room temperature and 300 °C using recently developed non-standard specimens' geometries. It was found that Incoloy 800 tubes exhibited higher J-resistance curves than Inconel 690 for both crack orientations. For both materials, circumferential cracks resulted into higher fracture resistance than longitudinal cracks, indicating a certain degree of texture anisotropy introduced by the tube fabrication process. From a practical point of view, temperature effects have found to be negligible in all cases. The results obtained in the present work provide a general framework for further application to structural integrity assessments of cracked tubes in a variety of nuclear steam generator designs.

REIMR - A Process for Utilizing Liquid Rocket Propulsion-Oriented 'Lessons Learned' to Mitigate Development Risk in Nuclear Thermal Propulsion

NASA Technical Reports Server (NTRS)

Ballard, RIchard O.

2006-01-01

This paper is a summary overview of a study conducted at the NASA Marshall Space Flight Center (NASA MSFC) during the initial phases of the Space Launch Initiative (SLI) program to evaluate a large number of technical problems associated with the design, development, test, evaluation and operation of several major liquid propellant rocket engine systems (i.e., SSME, Fastrac, J-2, F-1). One of the primary results of this study was the identification of the Fundamental Root Causes that enabled the technical problems to manifest, and practices that can be implemented to prevent them from recurring in future propulsion system development efforts, such as that which is currently envisioned in the field of nuclear thermal propulsion (NTF). This paper will discuss the Fundamental Root Causes, cite some examples of how the technical problems arose from them, and provide a discussion of how they can be mitigated or avoided in the development of an NTP system

Experimental and theoretical NMR and IR studies of the side-chain orientation effects on the backbone conformation of dehydrophenylalanine residue.

PubMed

Buczek, Aneta M; Ptak, Tomasz; Kupka, Teobald; Broda, Małgorzata A

2011-06-01

Conformation of N-acetyl-(E)-dehydrophenylalanine N', N'-dimethylamide (Ac-(E)-ΔPhe-NMe(2)) in solution, a member of (E)-α, β-dehydroamino acids, was studied by NMR and infrared spectroscopy and the results were compared with those obtained for (Z) isomer. To support the spectroscopic interpretation, the Φ, Ψ potential energy surfaces were calculated at the MP2/6-31 + G(d,p) level of theory in chloroform solution modeled by the self-consistent reaction field-polarizable continuum model method. All minima were fully optimized by the MP2 method and their relative stabilities were analyzed in terms of π-conjugation, internal H-bonds and dipole interactions between carbonyl groups. The obtained NMR spectral features were compared with theoretical nuclear magnetic shieldings, calculated using Gauge Independent Atomic Orbitals (GIAO) approach and rescaled to theoretical chemical shifts using benzene as reference. The calculated indirect nuclear spin-spin coupling constants were compared with available experimental parameters. Copyright © 2011 John Wiley & Sons, Ltd.

Co1 DNA supports conspecificity of Geomyphilus pierai and G. barrerai (Coleoptera, Scarabaeidae, Aphodiinae) and is a good marker for their phylogeographic investigation in Mexican mountains

PubMed Central

Arriaga-Jiménez, Alfonsina; Roy, Lise

2015-01-01

Abstract Members of Geomyphilus are associated with rodent burrows, such as pocket gophers and prairie dogs. In Mexico, they are found in the mountains of the Mexican Volcanic Belt and in Sierra Madre Oriental. Our study aims to initiate the exploration of the dispersal modes of Geomyphilus pierai and Geomyphilus barrerai from burrows of pocket gophers. In order to estimate the dispersal scale of the beetles, the utility of mitochondrial and nuclear molecular markers for studying the phylogeographic structure of this complex of species (Geomyphilus pierai and Geomyphilus barrerai) was tested from 49 beetle individuals. High intraspecific and intra-mountain nucleotidic diversity was captured from this sample using Co1 mitochondrial sequences, whilst the ITS2 nuclear ribosomal sequence did not allow observing informative variation. Mitochondrial phylogenetic analysis revealed that the specific delineation between the two species under study was doubtful. In this preliminary study, Co1 was shown to be a good marker for elucidating dispersal routes of the burrowing rodent-associated beetles. PMID:26257561

Box C/D sRNA stem ends act as stabilizing anchors for box C/D di-sRNPs.

PubMed

Yip, W S Vincent; Shigematsu, Hideki; Taylor, David W; Baserga, Susan J

2016-10-14

Ribosomal RNA (rRNA) modifications are essential for ribosome function in all cellular organisms. Box C/D small (nucleolar) ribonucleoproteins [s(no)RNPs] catalyze 2'-O-methylation, one rRNA modification type in Eukarya and Archaea. Negatively stained electron microscopy (EM) models of archaeal box C/D sRNPs have demonstrated the dimeric sRNP (di-sRNP) architecture, which has been corroborated by nuclear magnetic resonance (NMR) studies. Due to limitations of the structural techniques, the orientation of the box C/D sRNAs has remained unclear. Here, we have used cryo-EM to elucidate the sRNA orientation in a M. jannaschii box C/D di-sRNP. The cryo-EM reconstruction suggests a parallel orientation of the two sRNAs. Biochemical and structural analyses of sRNPs assembled with mutant sRNAs indicate a potential interaction between the sRNA stem ends. Our results suggest that the parallel arrangement of the sRNAs juxtaposes their stem ends into close proximity to allow for a stabilizing interaction that helps maintain the di-sRNP architecture. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Micronuclei and other erythrocyte nuclear abnormalities in fishes from the Great Lakes Basin, USA

PubMed Central

Braham, Ryan P.; Shaw, Cassidy H.; Mazik, Patricia M.; Umbuzeiro, G.

2017-01-01

Biological markers (biomarkers) sensitive to genotoxic and mutagenic contamination in fishes are widely used to identify exposure effects in aquatic environments. The micronucleus assay was incorporated into a suite of indicators to assess exposure to genotoxic and mutagenic contamination at five Great Lakes Areas of Concern (AOCs), as well as one non‐AOC (reference) site. The assay allowed enumeration of micronuclei as well as other nuclear abnormalities for both site and species comparisons. Erythrocyte abnormality data was also compared to skin and liver tumor prevalence and hepatic transcript abundance. Erythrocyte abnormalities were observed at all sites with variable occurrence and severity among sites and species. Benthic‐oriented brown bullhead (Ameiurus nebulosus) and white sucker (Catostomus commersonii) expressed lower rates of erythrocyte abnormalities, but higher rates of skin and liver neoplasms, when compared to pelagic‐oriented largemouth bass (Micropterus salmoides) or smallmouth bass (Micropterus dolomieu) at the same site. The reduced erythrocyte abnormalities, increased transcript abundance associated with Phase I and II toxicant responsive pathways, and increased neoplastic lesions among benthic‐oriented taxa may indicate the development of contaminant resistance of these species to more acute effects. Environ. Mol. Mutagen. 58:570–581, 2017. © 2017 This article is a U.S. Government work and is in the public domain in the USA. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society PMID:28868735

On-Going International Research Program on Irradiated Concrete Conducted by DOE, EPRI and Japan Research Institutions. Roadmap, Achievements and Path Forward

DOE Office of Scientific and Technical Information (OSTI.GOV)

Le Pape, Yann; Rosseel, Thomas M.

The Joint Department of Energy (DOE)-Electric Power Research Institute (EPRI) Program (Light Water Reactor Sustainability (LWRS) Program–Material Pathway–Concrete and Long-Term Operation (LTO) Program) and US Nuclear Regulatory Commission (NRC) research studies aim at understanding the most prominent degradation modes and their effects on the long-term operation of concrete structures to nuclear power generation. Based on the results of the Expanded Materials Degradation Analysis (EMDA), (NUREG/CR-7153, ORNL/TM-2011/545), irradiated concrete and alkali-silica reaction (ASR)-affected concrete structures are the two prioritized topics of on-going research. This report focuses specifically on the topic of irradiated concrete and summarizes the main accomplishments obtained by thismore » joint program, but also provides an overview of current relevant activities domestically and internationally. Possible paths forward are also suggested to help near-future orientation of this program.« less

Diffusion of water in the endosperm tissue of wheat grains as studied by pulsed field gradient nuclear magnetic resonance.

PubMed

Callaghan, P T; Jolley, K W; Lelievre, J

1979-10-01

Pulsed field gradient nuclear magnetic resonance has been used to measure water self-diffusion coefficients in the endosperm tissue of wheat grains as a function of the tissue water content. A model that confines the water molecules to a randomly oriented array of capillaries with both transverse dimension less than 100 nm has been used to fit the data and give a unique diffusion coefficient at each water content. The diffusion rates vary from 1.8 x 10(-10) m2s-1 at the lowest to 1.2 x 10(-9) m2s-1 at the highest moisture content. This variation can be explained in terms of an increase in water film thickness from approximately 0.5 to approximately 2.5 nm over the moisture range investigated (200-360 mg g-1).

The Inner Structure of OH Megamaser Galaxies: The Genesis of the Unified Scheme of Active Galactic Nuclei

NASA Astrophysics Data System (ADS)

Axon, David

OH megamaser galaxies (OHMG) represent a key post-merger phase in the evolution of the Ultra-Luminous Infrared Galaxies (ULIRGs) population, in which an edge-on circum-nuclear gas disk (proto-torus) has already formed. Detailed interferometric mapping of maser sources implies that they originate in dense edge-on rotating molecular gas within a few tens of parsecs of the AGN. In addition, the OH lines are often broad (Doppler widths ~ 1000 km/s), implying large dynamical masses in the central few parsecs. In many systems the OH lines also show high velocity asymmetric tails suggesting large-scale outflows that could be clearing away enshrouding dense molecular material. Taken together this evidence points to a picture in which an OHMG hosts a nascent QSO surrounded by a flattened distribution of dense molecular gas that is in the process of being cleared away along the rotation axis of the maser disk. A great advantage of studying OHMG systems over the general ULIRG population is that the circum-nuclear disks are effectively "fixed" at an edge on orientation, thereby breaking the degeneracy between the number of clumps and inclination in state of the art clumpy torus models. We have been awarded HST time in cycle 17 to conduct a comprehensive study of structure of the circum-nuclear gas, and its relationship to the radio structure and that of the maser disk, of large sample (80) of OHMG. This work is supported by ground-based spectropolarimetry, integral field spectroscopy and new radio continuum observations, Our overall objective is to probe the final stages of evolution immediately before the full- emergence of an enshrouded AGN as the circum-nuclear dust is dispersed by starburst and AGN-induced outflows. The specific scientific goals of this ADP proposal are to retrieve and analyze the Spitzer thermal-IR 5-70 micron imaging and IRS spectra of the subset of 72 of our targets for which Spitzer observations are available in the archive. We aim to establish the relationship between host and circum-nuclear ionized gas and dust structures in different OHMG spectroscopic types (AGN, Starburst, Composite) and model the AGN and starburst contributions to the mid-IR SED. Combining these with our other data we will address a number of important questions: is the mid-IR SED consistent with an edge-on circum-nuclear dust structure, as expected from the maser observations? What is the relative orientation of the Maser molecular structure and the ionized gas? Is there a connection between AGN heating of the circum-nuclear dust and wind or radiation driven outflows from the nucleus? How does the bolometric luminosity of the AGN relate to the OH line luminosity, FWHM and line shape? In turn these will relate the ionizing luminosity to the covering factor of the torus and the enclosed dynamical mass. When complete, this study should provide new insights on the relationships between the fundamental physical parameters of the AGN, including black hole mass, accretion and mass outflow rates, and the large scale properties of the host galaxy.

Flight test techniques for validating simulated nuclear electromagnetic pulse aircraft responses

NASA Technical Reports Server (NTRS)

Winebarger, R. M.; Neely, W. R., Jr.

1984-01-01

An attempt has been made to determine the effects of nuclear EM pulses (NEMPs) on aircraft systems, using a highly instrumented NASA F-106B to document the simulated NEMP environment at the Kirtland Air Force Base's Vertically Polarized Dipole test facility. Several test positions were selected so that aircraft orientation relative to the test facility would be the same in flight as when on the stationary dielectric stand, in order to validate the dielectric stand's use in flight configuration simulations. Attention is given to the flight test portions of the documentation program.

Is there evidence for a nuclear Foucault pendulum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hilton, R.R.

1990-12-03

Recent observations of the giant dipole resonance in states at high angular momentum and temperature have shown an effective narrowing of the resonance. It is pointed out that this may be interpreted as a signature of rotation of the nucleus about a symmetry axis. In this limit, the giant dipole orientation freezes in the plane of rotation, the analog of the Foucault pendulum positioned at the North Pole. All effects of rotation, other than those of pure deformation, cease to be present. In this region it is thus possible to probe the nuclear shape directly, uncontaminated by rotational effects.

Framing Political Messages to Fit the Audience’s Regulatory Orientation: How to Improve the Efficacy of the Same Message Content

PubMed Central

Mannetti, Lucia; Brizi, Ambra; Giacomantonio, Mauro; Higgins, E. Tory

2013-01-01

This research investigates how the impact of persuasive messages in the political domain can be improved when fit is created by subliminally priming recipients’ regulatory focus (either promotion or prevention) and by linguistic framing of the message (either strategic approach framing or strategic avoidance framing). Results of two studies show that regulatory fit: a) increases the impact of a political message favoring nuclear energy on implicit attitudes of the target audience (Study 1); and b) induces a more positive evaluation of, and intentions to vote for, the political candidate who is delivering a message concerning immigration policies (Study 2). PMID:24130831

Preparing to understand and use science in the real world: interdisciplinary study concentrations at the Technical University of Darmstadt.

PubMed

Liebert, Wolfgang J

2013-12-01

In order to raise awareness of the ambiguous nature of scientific-technological progress, and of the challenging problems it raises, problems which are not easily addressed by courses in a single discipline and cannot be projected onto disciplinary curricula, Technical University of Darmstadt has established three interdisciplinary study concentrations: "Technology and International Development", "Environmental Sciences", and "Sustainable Shaping of Technology and Science". These three programmes seek to overcome the limitations of strictly disciplinary research and teaching by developing an integrated, problem-oriented approach. For example, one course considers fundamental nuclear dilemmas and uses role-playing techniques to address a controversy in the area of nuclear security. At the same time, incorporating interdisciplinary teaching into a university that is organized around mono- or multi-disciplinary faculties also poses a number of challenges. Recognition in disciplinary curricula, and appropriate organizational support and funding are examples of those challenges. It is expected that science and engineering students, empowered by such interdisciplinary study programmes, will be better prepared to act responsibly with regard to scientific and technological challenges.

The NIAID Radiation Countermeasures Program Business Model

PubMed Central

Hafer, Nathaniel; Maidment, Bert W.

2010-01-01

The National Institute of Allergy and Infectious Diseases (NIAID) Radiation/Nuclear Medical Countermeasures Development Program has developed an integrated approach to providing the resources and expertise required for the research, discovery, and development of radiation/nuclear medical countermeasures (MCMs). These resources and services lower the opportunity costs and reduce the barriers to entry for companies interested in working in this area and accelerate translational progress by providing goal-oriented stewardship of promising projects. In many ways, the radiation countermeasures program functions as a “virtual pharmaceutical firm,” coordinating the early and mid-stage development of a wide array of radiation/nuclear MCMs. This commentary describes the radiation countermeasures program and discusses a novel business model that has facilitated product development partnerships between the federal government and academic investigators and biopharmaceutical companies. PMID:21142762

The NIAID Radiation Countermeasures Program business model.

PubMed

Hafer, Nathaniel; Maidment, Bert W; Hatchett, Richard J

2010-12-01

The National Institute of Allergy and Infectious Diseases (NIAID) Radiation/Nuclear Medical Countermeasures Development Program has developed an integrated approach to providing the resources and expertise required for the research, discovery, and development of radiation/nuclear medical countermeasures (MCMs). These resources and services lower the opportunity costs and reduce the barriers to entry for companies interested in working in this area and accelerate translational progress by providing goal-oriented stewardship of promising projects. In many ways, the radiation countermeasures program functions as a "virtual pharmaceutical firm," coordinating the early and mid-stage development of a wide array of radiation/nuclear MCMs. This commentary describes the radiation countermeasures program and discusses a novel business model that has facilitated product development partnerships between the federal government and academic investigators and biopharmaceutical companies.

Operations FLINTLOCK and LATCHKEY events RED HOT, PIN STRIPE, DISCUS THROWER, PILE DRIVER, DOUBLE PLAY, NEWPOINT, MIDI MIST, 5 March 1966-26 Jun 1967. Technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horton, K.K.; Eubank, B.F.; Brady, W.J.

1984-10-01

This report is a personnel-oriented history of DOD participation in underground nuclear weapons testing during Operations FLINTLOCK and LATCHKEY, test events RED HOT, PIN STRIPE, DISCUS THROWER, PILE DRIVER, DOUBLE PLAY, NEW POINT, and MIDI MIST, from 5 March 1966 to 26 June 1967. It is the second in a series of historical reports which will include all DOD underground nuclear weapons tests and all DOE underground nuclear weapons tests with significant DOD participation from 1962 forward. In addition to these historical volumes, a later restricted distribution volume will identify all DOD participants (military, civilian, and civilian contractors) and willmore » list their radiation dosimetry data.« less

Nuclear accident at Three Mile Island: its effect on a local community

DOE Office of Scientific and Technical Information (OSTI.GOV)

Behler, G.T. Jr.

1987-01-01

This dissertation consists of a longitudinal case study of the extent to which the structure of community power in Riverside, (a pseudonym) Pennsylvania (the largest community located within five miles of the Three Mile Island nuclear facility) changed as a result of the March, 1979 accident. The investigation centers around testing a basic working hypothesis. Simply stated, this working hypothesis argues that Riverside's power structure has become more pluralistic in response to the Three Mile Island nuclear accident. An additional corollary to this working hypothesis is also tested. This corollary asserts that many of Riverside's community power actors have becomemore » much more cosmopolitan in their political-action tactics and problem-solving orientations as a results of the TMI crisis. The aforementioned working hypothesis and associated corollary are tested via the combined utilization of three different techniques for measuring the distribution of social power. The findings of the study clearly demonstrate the existence of increased pluralism, politicization, and cosmopolitanism within Riverside since March of 1979. Furthermore, these research results, and the entire dissertation itself, contribute to a number of subfields within the discipline of sociology. In particular,contributions are noted for the subfields of community power, social movements, and disaster research.« less

Fractures in outcrops in the vicinity of drill hole USW G-4. Yucca Mountain, Nevada; data analysis and compilation

USGS Publications Warehouse

Barton, Christopher C.; Page, William R.; Morgan, Terrance L.

1989-01-01

Fractures on outcrops in the vicinity of drill hole USW G-4, Yucca Mountain, Nevada, were studied in order to contribute to characterization of fractures for hydrologjc, geomechanical, and tectonic modeling of the Yucca Mountain block and to characterize fractures prior to the excavation of a proposed exploratory shaft located near USW G-4. Yucca Mountain is a prospective site for the construction of an underground repository for high-level nuclear waste.Measurements were taken and recorded on 5,000 fractures at 50 outcrop stations primarily in the upper lithophysal unit of the Tiva Canyon Member of the Miocene Paintbrush Tuff. Fracture orientation and surface roughness were recorded for each fracture. Additionally, notes were taken on fracture abutting, crossing, and offsetting relations, swarming, curvature, brecciation, slickensides, and fracture fillings. Frequency distributions of orientation and roughness were plotted and analyzed. Fractures with low roughness coefficients (0-4) group tightly into two sets based on orientation. We conclude that such fractures are cooling joints and that all other fractures are tectonic. The development of small-scale fractures adjacent, subparallel, and possibly related to the Ghost Dance fault has been addressed in a preliminary way based on data collected in this study. Such sympathetic fractures are abundant in the upper cliff unit but not in the upper lithophysal unit.

Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agents.

PubMed

Lu, Junxuan; Kim, Sung-Hoon; Jiang, Cheng; Lee, HyoJeong; Guo, Junming

2007-09-01

Androgen and androgen receptor (AR) signaling are crucial for the genesis of prostate cancer (PCa), which can often develop into androgen-ligand-independent diseases that are lethal to the patients. Recent studies show that even these hormone-refractory PCa require ligand-independent AR signaling for survival. As current chemotherapy is largely ineffective for PCa and has serious toxic sideeffects, we have initiated a collaborative effort to identify and develop novel, safe and naturally occurring agents that target AR signaling from Oriental medicinal herbs for the chemoprevention and treatment of PCa. We highlight our discovery of decursin from an Oriental formula containing Korean Angelica gigas Nakai (Dang Gui) root as a novel anti-androgen/AR agent. We have identified the following mechanisms to account for the specific anti-AR actions: rapid block of AR nuclear translocation, inhibition of binding of 5alpha-dihydrotestesterone to AR and increased proteasomal degradation of AR protein. Furthermore, decursin lacks the agonist activity of the "pure" anti-androgen bicalutamide and is more potent than bicalutamide in inducing PCa apoptosis. Structure-activity analyses reveal a critical requirement of the side-chain on decursin or its structural isomer decursinol angelate for anti-AR, cell cycle arrest and proapoptotic activities. This work demonstrates the feasibility of using activity-guided fractionation in cell culture assays combined with mechanistic studies to identify novel anti-androgen/ AR agents from complex herbal mixtures.

Intimal cushions and endothelial nuclear elongation around mouse aortic branches and their spatial correspondence with patterns of lipid deposition

PubMed Central

Bond, Andrew R.; Ni, Chih-Wen; Jo, Hanjoong

2010-01-01

Spatial variation in hemodynamic stresses acting on the arterial wall may explain the nonuniform distribution of atherosclerosis. In thoracic aortas of LDL receptor/apolipoprotein E double knockout mice, lesions develop preferentially around the entire circumference of intercostal branch ostia, regardless of age, with the highest prevalence occurring upstream. Additional chevron-shaped lesions occur further upstream of the ostia. This pattern differs from the age-related ones occurring in people and rabbits. In the present study, patterns of near-wall blood flow around intercostal ostia in wild-type mice were estimated from the morphology of endothelial nuclei, which were shown in vitro to elongate in response to elevated shear stress and to align with the flow, and wall structure was assessed from confocal and scanning electron microscopy. A triangular intimal cushion surrounded the upstream part of most ostia. Nuclear length-to-width ratios were lowest over this cushion and highest at the sides of branches, regardless of age. Nuclear orientations were consistent with flow diverging around the branch. The pattern of nuclear morphology differed from the age-related ones observed in rabbits. The intimal cushion and the distribution of shear stress inferred from these observations can partly account for the pattern of lesions observed in knockout mice. Nuclear elongation in nonbranch regions was approximately constant across animals of different size, demonstrating the existence of a mechanism by which endothelial cells compensate for the dependence of mean aortic wall shear stress on body mass. PMID:19933414

Children's adjustment in non-traditional families in Israel: the effect of parental sexual orientation and the number of parents on children's development.

PubMed

Shechner, T; Slone, M; Lobel, T E; Shechter, R

2013-03-01

This study examined differences in children's psychological and social indicators in non-traditional families in Israel, focusing on fatherless families headed by lesbian mothers and single mothers by choice. Although Israel is considered an industrialized westernized country, centrality of the traditional nuclear family predominates this country. This factorial design study included four family types: lesbian and heterosexual mothers, each in both single and coupled parenthood. Children's measures included the Child Behavior Checklist, perception of peer relations and perceived self-competence. Children from single parent as opposed to two-parent families exhibited more externalizing behaviour problems and aggressiveness. Children of lesbian mothers reported more prosocial behaviours and less loneliness than children from heterosexual families. No differences emerged for perceived self-competence across family types. Mother's sexual orientation did not affect children's adjustment negatively, whereas single parenthood placed children at greater risk for some difficulties. Implications include the need for apprising health professionals of effects of family types on children's development. © 2011 Blackwell Publishing Ltd.

Location and ion-binding of membrane-associated valinomycin, a proton nuclear magnetic resonance study.

PubMed

Meers, P; Feigenson, G W

1988-03-03

Valinomycin, incorporated in small unilamellar vesicles of perdeuterated dimyristoylphosphatidylcholine, reveals several well-resolved 1H-NMR resonances. These resonances were used to examine the location, orientation and ion-binding of membrane-bound valinomycin. The order of affinity of membrane-bound valinomycin for cations is Rb+ greater than K+ greater than Cs+ greater than Ba2+, and binding is sensitive to surface change. The exchange between bound and free forms is fast on the NMR time scale. The intrinsic binding constants, extrapolated to zero anion concentration, are similar to those determined in aqueous solution. Rb+ and K+ show 1:1 binding to valinomycin, whereas the stoichiometry of Cs+ and Ba2+ is not certain. Paramagnetic chemical shift reagents and nitroxide spin label relaxation probes were used to study the location and orientation of valinomycin in the membrane. Despite relatively fast exchange of bound cations, the time average location of the cation-free form of valinomycin is deep within the bilayer under the conditions of these experiments. Upon complexation to K+, valinomycin moves closer to the interfacial region.

Numerical study of ultra-low field nuclear magnetic resonance relaxometry utilizing a single axis magnetometer for signal detection.

PubMed

Vogel, Michael W; Vegh, Viktor; Reutens, David C

2013-05-01

This paper investigates optimal placement of a localized single-axis magnetometer for ultralow field (ULF) relaxometry in view of various sample shapes and sizes. The authors used finite element method for the numerical analysis to determine the sample magnetic field environment and evaluate the optimal location of the single-axis magnetometer. Given the different samples, the authors analysed the magnetic field distribution around the sample and determined the optimal orientation and possible positions of the sensor to maximize signal strength, that is, the power of the free induction decay. The authors demonstrate that a glass vial with flat bottom and 10 ml volume is the best structure to achieve the highest signal out of samples studied. This paper demonstrates the importance of taking into account the combined effects of sensor configuration and sample parameters for signal generation prior to designing and constructing ULF systems with a single-axis magnetometer. Through numerical simulations the authors were able to optimize structural parameters, such as sample shape and size, sensor orientation and location, to maximize the measured signal in ultralow field relaxometry.

Inhibitory effect of traditional oriental medicine-derived monoamine oxidase B inhibitor on radioresistance of non-small cell lung cancer.

PubMed

Son, Beomseok; Jun, Se Young; Seo, HyunJeong; Youn, HyeSook; Yang, Hee Jung; Kim, Wanyeon; Kim, Hyung Kook; Kang, ChulHee; Youn, BuHyun

2016-02-24

Increased survival of cancer cells mediated by high levels of ionizing radiation (IR) reduces the effectiveness of radiation therapy for non-small cell lung cancer (NSCLC). In the present study, danshensu which is a selected component of traditional oriental medicine (TOM) compound was found to reduce the radioresistance of NSCLC by inhibiting the nuclear factor-κB (NF-κB) pathway. Of the various TOM compounds reported to inhibit the IR activation of NF-κB, danshensu was chosen as a final candidate based on the results of structural comparisons with human metabolites and monoamine oxidase B (MAOB) was identified as the putative target enzyme. Danshensu decreased the activation of NF-κB by inhibiting MAOB activity in A549 and NCI-H1299 NSCLC cells. Moreover, it suppressed IR-induced epithelial-to-mesenchymal transition, expressions of NF-κB-regulated prosurvival and proinflammatory genes, and in vivo radioresistance of mouse xenograft models. Taken together, this study shows that danshensu significantly reduces MAOB activity and attenuates NF-κB signaling to elicit the radiosensitization of NSCLC.

73Ge-NMR study on magnetic fluctuations of ferromagnetic superconductor UGe2

NASA Astrophysics Data System (ADS)

Noma, Y.; Kotegawa, H.; Kubo, T.; Tou, H.; Harima, H.; Haga, Y.; Yamamoto, E.; Ōnuki, Y.; Itoh, K. M.; Haller, E. E.; Nakamura, A.; Homma, Y.; Honda, F.; Aoki, D.

2018-05-01

We report 73Ge-NMR measurement on the ferromagnetic superconductor UGe2 at ambient pressure. The observed NMR spectrum supports that the electric field gradient at three inequivalent Ge sites is correctly deduced by a LDA calculation. The temperature dependences of the nuclear spin lattice relaxation rate 1 /T1 for H0 ⊥ a (easy axis) and H0 ∥ a were obtained for the oriented sample. The contrasting behavior in 1 /T1 for H0 ⊥ a and H0 ∥ a reveals that the magnetic fluctuation of UGe2 is highly anisotropic.

The fine structure of the sperm of the round goby (Neogobius melanostomus)

USGS Publications Warehouse

Allen, Jeffrey D.; Walker, Glenn K.; Nichols, Susan J.; Sorenson, Dorothy

2004-01-01

The fine structural details of the spermatozoon of the round goby are presented for the first time in this study. Scanning and transmission electron microscopic examination of testis reveals an anacrosomal spermatozoon with a slightly elongate head and uniformly compacted chromatin. The midpiece contains a single, spherical mitochondrion. Two perpendicularly oriented centrioles lie in a deep, eccentric nuclear fossa with no regularly observed connection to the nucleus. The flagellum develops bilateral fins soon after emerging from the fossa; each extends approximately 1 A?m from the axoneme and persists nearly the length of the flagellum.

Status of Initial Assessment of Physical and Mechanical Properties of Graphite Grades for NGNP Appkications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strizak, Joe P; Burchell, Timothy D; Windes, Will

2011-12-01

Current candidate graphite grades for the core structures of NGNP include grades NBG-17, NBG-18, PCEA and IG-430. Both NBG-17 and NBG-18 are manufactured using pitch coke, and are vibrationally molded. These medium grain products are produced by SGL Carbon SAS (France). Tayo Tanso (Japan) produces IG-430 which is a petroleum coke, isostatically molded, nuclear grade graphite. And PCEA is a medium grain, extruded graphite produced by UCAR Carbon Co. (USA) from petroleum coke. An experimental program has been initiated to develop physical and mechanical properties data for these current candidate graphites. The results will be judged against the requirements formore » nuclear grade graphites set forth in ASTM standard D 7219-05 "Standard Specification for Isotropic and Near-isotropic Nuclear Graphites". Physical properties data including thermal conductivity and coefficient of thermal expansion, and mechanical properties data including tensile, compressive and flexural strengths will be obtained using the established test methods covered in D-7219 and ASTM C 781-02 "Standard Practice for Testing Graphite and Boronated Graphite Components for High-Temperature Gas-Cooled Nuclear Reactors". Various factors known to effect the properties of graphites will be investigated. These include specimen size, spatial location within a graphite billet, specimen orientation (ag and wg) within a billet, and billet-to-billet variations. The current status of the materials characterization program is reported herein. To date billets of the four graphite grades have been procured, and detailed cut up plans for obtaining the various specimens have been prepared. Particular attention has been given to the traceability of each specimen to its spatial location and orientation within a billet.« less

Effect of specimen size and grain orientation on the mechanical and physical properties of NBG-18 nuclear graphite

DOE PAGES

Vasudevamurthy, G.; Byun, T. S.; Pappano, Pete; ...

2015-03-13

Here we present a comparison of the measured baseline mechanical and physical properties of with grain (WG) and against grain (AG) non-ASTM size NBG-18 graphite. The objectives of the experiments were twofold: (1) assess the variation in properties with grain orientation; (2) establish a correlation between specimen tensile strength and size. The tensile strength of the smallest sized (4 mm diameter) specimens were about 5% higher than the standard specimens (12 mm diameter) but still within one standard deviation of the ASTM specimen size indicating no significant dependence of strength on specimen size. The thermal expansion coefficient and elastic constantsmore » did not show significant dependence on specimen size. Lastly, experimental data indicated that the variation of thermal expansion coefficient and elastic constants were still within 5% between the different grain orientations, confirming the isotropic nature of NBG-18 graphite in physical properties.« less

Developing the nuclear idea: concept, technique, and process.

PubMed

Billow, Richard M

2013-10-01

I introduce an approach to group that has remained undeveloped in the literature, but represents an essence of relationally oriented group psychotherapy. Evolving from the verbalizations and enactments through which the group symbolizes and becomes known-a nuclear idea takes shape. It emerges from the nucleus of the group process: co-created from intersubjective forces and locations that cannot be fully specified, yet may be possible to observe, name, and utilize clinically. Groups organize themselves by developing nuclear ideas, with the therapist's active participation. They are vehicles through which a group comes to think about its thinking: not only what it thinks, but also how it thinks, or chooses not to think, and when and why. Developing the nuclear idea provides a framework for how the therapist-and the group itself-goes about the task of containing. With its emphasis on meaning and the development of meaning as transformational, the concept of the nuclear idea supplements the whole group, interpersonal, and intrapsychic lenses through which the therapist comes to understand group experience and base interventions. Clinical vignettes illustrate how the therapist may develop nuclear ideas thematically, conceptualize further, and negotiate meaning with the co-participation of other group members.

The CCONE Code System and its Application to Nuclear Data Evaluation for Fission and Other Reactions

NASA Astrophysics Data System (ADS)

Iwamoto, O.; Iwamoto, N.; Kunieda, S.; Minato, F.; Shibata, K.

2016-01-01

A computer code system, CCONE, was developed for nuclear data evaluation within the JENDL project. The CCONE code system integrates various nuclear reaction models needed to describe nucleon, light charged nuclei up to alpha-particle and photon induced reactions. The code is written in the C++ programming language using an object-oriented technology. At first, it was applied to neutron-induced reaction data on actinides, which were compiled into JENDL Actinide File 2008 and JENDL-4.0. It has been extensively used in various nuclear data evaluations for both actinide and non-actinide nuclei. The CCONE code has been upgraded to nuclear data evaluation at higher incident energies for neutron-, proton-, and photon-induced reactions. It was also used for estimating β-delayed neutron emission. This paper describes the CCONE code system indicating the concept and design of coding and inputs. Details of the formulation for modelings of the direct, pre-equilibrium and compound reactions are presented. Applications to the nuclear data evaluations such as neutron-induced reactions on actinides and medium-heavy nuclei, high-energy nucleon-induced reactions, photonuclear reaction and β-delayed neutron emission are mentioned.

Proliferation-dependent positioning of individual centromeres in the interphase nucleus of human lymphoblastoid cell lines

PubMed Central

Ollion, Jean; Loll, François; Cochennec, Julien; Boudier, Thomas; Escudé, Christophe

2015-01-01

The cell nucleus is a highly organized structure and plays an important role in gene regulation. Understanding the mechanisms that sustain this organization is therefore essential for understanding genome function. Centromeric regions (CRs) of chromosomes have been known for years to adopt specific nuclear positioning patterns, but the significance of this observation is not yet completely understood. Here, using a combination of fluorescence in situ hybridization and immunochemistry on fixed human cells and high-throughput imaging, we directly and quantitatively investigated the nuclear positioning of specific human CRs. We observe differential attraction of individual CRs toward both the nuclear border and the nucleoli, the former being enhanced in nonproliferating cells and the latter being enhanced in proliferating cells. Similar positioning patterns are observed in two different lymphoblastoid cell lines. Moreover, the positioning of CRs differs from that of noncentromeric regions, and CRs display specific orientations within chromosome territories. These results suggest the existence of not-yet-characterized mechanisms that drive the nuclear positioning of CRs and therefore pave the way toward a better understanding of how CRs affect nuclear organization. PMID:25947134

Chiral discrimination in NMR spectroscopy: computation of the relevant molecular pseudoscalars

NASA Astrophysics Data System (ADS)

Buckingham, A. David; Lazzeretti, Paolo; Pelloni, Stefano

2015-07-01

Nuclear magnetic resonance (NMR) is normally blind to chirality but it has been predicted that precessing nuclear spins in a strong magnetic field induce a rotating electric polarisation that is of opposite sign for enantiomers. The polarisation is determined by two pseudoscalars, ? and ?. The former arises from the distortion of the electronic structure by the nuclear magnetic moment in the presence of the strong magnetic field and is equivalent to the linear effect of an electric field on the nuclear shielding tensor. ? determines the temperature-dependent partial orientation of the permanent electric dipole moment of the molecule by the antisymmetric part of the nuclear shielding tensor. Computations of these two contributions are reported for the nuclei in the chiral molecules N-methyloxaziridine, 2-methyloxirane, 1,3-dimethylallene, 1-fluoroethanol, 2-fluoroazirine, 1,2-M-dioxin, 1,2-M-dithiin, 1,2-M-diselenin and 1,2-M-ditellurin. For strongly dipolar molecules, ? is typically two to three orders of magnitude greater than ?, raising hopes for the detection of chirality in NMR spectroscopy. This paper is dedicated to the memory of Prof. Nicholas Handy, F.R.S.

The design of photoelectric signal processing system for a nuclear magnetic resonance gyroscope based on FPGA

NASA Astrophysics Data System (ADS)

Zhang, Xian; Zhou, Binquan; Li, Hong; Zhao, Xinghua; Mu, Weiwei; Wu, Wenfeng

2017-10-01

Navigation technology is crucial to the national defense and military, which can realize the measurement of orientation, positioning, attitude and speed for moving object. Inertial navigation is not only autonomous, real-time, continuous, hidden, undisturbed but also no time-limited and environment-limited. The gyroscope is the core component of the inertial navigation system, whose precision and size are the bottleneck of the performance. However, nuclear magnetic resonance gyroscope is characteristic of the advantage of high precision and small size. Nuclear magnetic resonance gyroscope can meet the urgent needs of high-tech weapons and equipment development of new generation. This paper mainly designs a set of photoelectric signal processing system for nuclear magnetic resonance gyroscope based on FPGA, which process and control the information of detecting laser .The photoelectric signal with high frequency carrier is demodulated by in-phase and quadrature demodulation method. Finally, the processing system of photoelectric signal can compensate the residual magnetism of the shielding barrel and provide the information of nuclear magnetic resonance gyroscope angular velocity.

Orientational alignment in solids from bidimensional isotropic-anisotropic nuclear magnetic resonance spectroscopy: applications to the analysis of aramide fibers.

PubMed

Sachleben, J R; Frydman, L

1997-02-01

The use of two-dimensional isotropic-anisotropic correlation spectroscopy for the analysis of orientational alignment in solids is presented. The theoretical background and advantages of this natural-abundance 13C NMR method of measurement are discussed, and demonstrated with a series of powder and single-crystal variable-angle correlation spectroscopy (VACSY) experiments on model systems. The technique is subsequently employed to analyze the orientational distributions of three polymer fibers: Kevlar 29, Kevlar 49 and Kevlar 149. Using complementary two-dimensional NMR data recorded on synthetic samples of poly(p-phenyleneterephthalamide), the precursor of Kevlar, it was found that these commercial fibers possess molecules distributed over a very narrow orientational range with respect to the macroscopic director. The widths measured for these director distribution arrangements were (12 +/- 1.5) degrees for Kevlar 29, (15 +/- 1.5) degrees for Kevlar 49, and (8 +/- 1.5) degrees for Kevlar 149. These figures compare well with previous results obtained for non-commercial fiber samples derived from the same polymer.

Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 3. Natural Disasters.

ERIC Educational Resources Information Center

Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

The effects of natural disasters and the implications which those effects have for community emergency preparedness are discussed. Major topics include: (1) Similarities and differences in types of responses required by a nuclear and natural disasters, (2) The civil defense function in natural disasters, (3) Vulnerability analysis, (4) Warning…

The Job Creation Potential of Solar and Conservation: A Critical Evaluation.

ERIC Educational Resources Information Center

Schachter, Mary

Solar proponents claim that a solar- and conservation-oriented economy will create vastly larger numbers of jobs than the conventional and nuclear alternatives. Comparing energy alternatives in terms of job creation potential is tenuous at best due to the paucity of analysis in this area. Ideally, both the quantitative and qualitative aspects of…

Low-Field Nuclear Polarization Using Nitrogen Vacancy Centers in Diamonds

NASA Astrophysics Data System (ADS)

Hovav, Y.; Naydenov, B.; Jelezko, F.; Bar-Gill, N.

2018-02-01

It was recently demonstrated that bulk nuclear polarization can be obtained using nitrogen vacancy (NV) color centers in diamonds, even at ambient conditions. This is based on the optical polarization of the NV electron spin, and using several polarization transfer methods. One such method is the nuclear orientation via electron spin locking (NOVEL) sequence, where a spin-locked sequence is applied on the NV spin, with a microwave power equal to the nuclear precession frequency. This was performed at relatively high fields, to allow for both polarization transfer and noise decoupling. As a result, this scheme requires accurate magnetic field alignment in order preserve the NV properties. Such a requirement may be undesired or impractical in many practical scenarios. Here we present a new sequence, termed the refocused NOVEL, which can be used for polarization transfer (and detection) even at low fields. Numerical simulations are performed, taking into account both the spin Hamiltonian and spin decoherence, and we show that, under realistic parameters, it can outperform the NOVEL sequence.

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.

PubMed

Fung, Ho Yee Joyce; Fu, Szu-Chin; Chook, Yuh Min

2017-03-10

Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015). Here, we show crystal structures of CRM1 bound to eight additional NESs which reveal diverse conformations that range from loop-like to all-helix, which occupy different extents of the invariant NES-binding groove. Analysis of all NES structures show 5-6 distinct backbone conformations where the only conserved secondary structural element is one turn of helix that binds the central portion of the CRM1 groove. All NESs also participate in main chain hydrogen bonding with human CRM1 Lys568 side chain, which acts as a specificity filter that prevents binding of non-NES peptides. The large conformational range of NES backbones explains the lack of a fixed pattern for its 3-5 hydrophobic anchor residues, which in turn explains the large array of peptide sequences that can function as NESs.

Gas Transport and Detection Following Underground Nuclear Explosions

NASA Astrophysics Data System (ADS)

Carrigan, C. R.; Sun, Y.; Wagoner, J. L.; Zucca, J. J.

2011-12-01

Some extremely rare radioactive noble gases are by-products of underground nuclear explosions, and the detection of significant levels of these gases (e.g., Xe-133 and Ar-37) at the surface is a very strong indicator of the occurrence of an underground nuclear event. Because of their uniqueness, such noble gas signatures can be confirmatory of the nuclear nature of an event while signatures from other important detection methods, such as anomalous seismicity, are generally not. As a result, noble gas detection at a suspected underground nuclear test site is considered to be the most important technique available to inspectors operating under the On-Site-Inspection protocol of the Comprehensive Nuclear Test Ban Treaty. A one-kiloton chemical underground explosion, the Non-Proliferation Experiment (NPE), was carried out at the Nevada Test Site in 1993 and represented the first On-Site-Inspection oriented test of subsurface gas transport with subsequent detection at the surface using soil gas sampling methods. A major conclusion of the experiment was that noble gases from underground nuclear tests have a good possibility of being detected even if the test is well contained. From this experiment and from computer simulations, we have also learned significant lessons about the modes of gas transport to the surface and the importance of careful subsurface sampling to optimize the detected noble gas signature. Understanding transport and sampling processes for a very wide range of geologic and testing scenarios presents significant challenges that we are currently addressing using sensitivity studies, which we attempt to verify using experiments such as the NPE and a new subsurface gas migration experiment that is now being undertaken at the National Center for Nuclear Security. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Nuclear Science Symposium, 21st, Scintillation and Semiconductor Counter Symposium, 14th, and Nuclear Power Systems Symposium, 6th, Washington, D.C., December 11-13, 1974, Proceedings

NASA Technical Reports Server (NTRS)

1975-01-01

Papers are presented dealing with latest advances in the design of scintillation counters, semiconductor radiation detectors, gas and position sensitive radiation detectors, and the application of these detectors in biomedicine, satellite instrumentation, and environmental and reactor instrumentation. Some of the topics covered include entopistic scintillators, neutron spectrometry by diamond detector for nuclear radiation, the spherical drift chamber for X-ray imaging applications, CdTe detectors in radioimmunoassay analysis, CAMAC and NIM systems in the space program, a closed loop threshold calibrator for pulse height discriminators, an oriented graphite X-ray diffraction telescope, design of a continuous digital-output environmental radon monitor, and the optimization of nanosecond fission ion chambers for reactor physics. Individual items are announced in this issue.

An automated geometric correction system for airborne multispectral scanner imagery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis-King, E.; Tinney, L.; Brickey, D.

1996-10-01

The United States Department of Energy (USDOE) maintains a Remote Sensing Laboratory (RSL) to support nuclear related programs of the US Government. The mission of the organization includes both emergency response and more routine environmental assessments of nuclear facilities. The USDOE RSL maintains a small fleet of specially equipped aircraft that are used as platforms for remote sensor systems. The aircraft include helicopters, light aircraft, and a business jet suitable for high altitude acquisitions. Multispectral scanners flown on these platforms are subject to geometric distortions related to variations in aircraft orientation (pitch, roll, and yaw), position, and velocity during datamore » acquistions.« less

Analysis of Measurement Error and Estimator Shape in Three-Point Hydraulic Gradient Estimators

NASA Astrophysics Data System (ADS)

McKenna, S. A.; Wahi, A. K.

2003-12-01

Three spatially separated measurements of head provide a means of estimating the magnitude and orientation of the hydraulic gradient. Previous work with three-point estimators has focused on the effect of the size (area) of the three-point estimator and measurement error on the final estimates of the gradient magnitude and orientation in laboratory and field studies (Mizell, 1980; Silliman and Frost, 1995; Silliman and Mantz, 2000; Ruskauff and Rumbaugh, 1996). However, a systematic analysis of the combined effects of measurement error, estimator shape and estimator orientation relative to the gradient orientation has not previously been conducted. Monte Carlo simulation with an underlying assumption of a homogeneous transmissivity field is used to examine the effects of uncorrelated measurement error on a series of eleven different three-point estimators having the same size but different shapes as a function of the orientation of the true gradient. Results show that the variance in the estimate of both the magnitude and the orientation increase linearly with the increase in measurement error in agreement with the results of stochastic theory for estimators that are small relative to the correlation length of transmissivity (Mizell, 1980). Three-point estimator shapes with base to height ratios between 0.5 and 5.0 provide accurate estimates of magnitude and orientation across all orientations of the true gradient. As an example, these results are applied to data collected from a monitoring network of 25 wells at the WIPP site during two different time periods. The simulation results are used to reduce the set of all possible combinations of three wells to those combinations with acceptable measurement errors relative to the amount of head drop across the estimator and base to height ratios between 0.5 and 5.0. These limitations reduce the set of all possible well combinations by 98 percent and show that size alone as defined by triangle area is not a valid discriminator of whether or not the estimator provides accurate estimates of the gradient magnitude and orientation. This research was funded by WIPP programs administered by the U.S Department of Energy. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

A Slowly Precessing Disk in the Nucleus of M31 as the Feeding Mechanism for a Central Starburst

NASA Astrophysics Data System (ADS)

Lockhart, K. E.; Lu, J. R.; Peiris, H. V.; Rich, R. M.; Bouchez, A.; Ghez, A. M.

2018-02-01

We present a kinematic study of the nuclear stellar disk in M31 at infrared wavelengths using high spatial resolution integral field spectroscopy. The spatial resolution achieved, FWHM = 0.″12 (0.45 pc at the distance of M31), has only previously been equaled in spectroscopic studies by space-based long-slit observations. Using adaptive-optics-corrected integral field spectroscopy from the OSIRIS instrument at the W. M. Keck Observatory, we map the line-of-sight kinematics over the entire old stellar eccentric disk orbiting the supermassive black hole (SMBH) at a distance of r < 4 pc. The peak velocity dispersion is 381 ± 55 km s‑1, offset by 0.″13 ± 0.″03 from the SMBH, consistent with previous high-resolution long-slit observations. There is a lack of near-infrared (NIR) emission at the position of the SMBH and young nuclear cluster, suggesting a spatial separation between the young and old stellar populations within the nucleus. We compare the observed kinematics with dynamical models from Peiris & Tremaine. The best-fit disk orientation to the NIR flux is [θ l , θ i , θ a ] = [‑33° ± 4°, 44° ± 2°, ‑15° ± 15°], which is tilted with respect to both the larger-scale galactic disk and the best-fit orientation derived from optical observations. The precession rate of the old disk is Ω P = 0.0 ± 3.9 km s‑1 pc‑1, lower than the majority of previous observations. This slow precession rate suggests that stellar winds from the disk will collide and shock, driving rapid gas inflows and fueling an episodic central starburst as suggested in Chang et al.

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. Carmack; L. Braase; F. Goldner

The mission of the Advanced Fuels Campaign (AFC) is to perform Research, Development, and Demonstration (RD&D) activities for advanced fuel forms (including cladding) to enhance the performance and safety of the nation’s current and future reactors, enhance proliferation resistance of nuclear fuel, effectively utilize nuclear energy resources, and address the longer-term waste management challenges. This includes development of a state of the art Research and Development (R&D) infrastructure to support the use of a “goal oriented science based approach.” AFC uses a “goal oriented, science based approach” aimed at a fundamental understanding of fuel and cladding fabrication methods and performancemore » under irradiation, enabling the pursuit of multiple fuel forms for future fuel cycle options. This approach includes fundamental experiments, theory, and advanced modeling and simulation. One of the most challenging aspects of AFC is the management, integration, and coordination of major R&D activities across multiple organizations. AFC interfaces and collaborates with Fuel Cycle Technologies (FCT) campaigns, universities, industry, various DOE programs and laboratories, federal agencies (e.g., Nuclear Regulatory Commission [NRC]), and international organizations. Key challenges are the development of fuel technologies to enable major increases in fuel performance (safety, reliability, power and burnup) beyond current technologies, and development of characterization methods and predictive fuel performance models to enable more efficient development and licensing of advanced fuels. Challenged with the research and development of fuels for two different reactor technology platforms, AFC targeted transmutation fuel development and focused ceramic fuel development for Advanced LWR Fuels.« less

Two-dimensional H2 in Si: Raman scattering and modeling study

NASA Astrophysics Data System (ADS)

Melnikov, V. V.; Hiller, M.; Lavrov, E. V.

2018-03-01

Molecular hydrogen trapped within {111}-oriented platelets in silicon is studied by means of Raman scattering and first principles theory. The rotational transition S0(0 ) (J =0 →J =2 ) of para-H2 (nuclear spin I =0 ) at 353 cm-1 is used as a probe. We find that for temperatures below 100 K the S0(0 ) Raman line starts to broaden asymmetrically, which is interpreted as the onset of a phase transition from a state with a short-range order ("gaseous" or "liquid" phase) to a two-dimensional molecular crystal lying in the {111} plane of silicon. The shape of the S0(0 ) line at helium temperatures strongly depends on the relative content of ortho- (nuclear spin I =1 ) and para-H2 revealing the details of the intermolecular interaction. A comprehensive theoretical analysis based on ab initio calculations, molecular dynamics simulations, and rotational spectra modeling reveals that the phase transition to the crystalline state of the two-dimensional hydrogen does occur at temperatures substantially higher compared to those of bulk H2.

Water dynamics on ice and hydrate lattices studied by second-order central-line stimulated-echo oxygen-17 nuclear magnetic resonance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adjei-Acheamfour, Mischa; Tilly, Julius F.; Beerwerth, Joachim

Oxygen-17 stimulated-echo spectroscopy is a novel nuclear magnetic resonance (NMR) technique that allows one to investigate the time scale and geometry of ultraslow molecular motions in materials containing oxygen. The method is based on detecting orientationally encoded frequency changes within oxygen’s central-transition NMR line that are caused by second-order quadrupolar interactions. In addition to the latter, the present theoretical analysis of various two-pulse echo and stimulated-echo pulse sequences takes also heteronuclear dipolar interactions into account. As an experimental example, the ultraslow water motion in polycrystals of tetrahydrofuran clathrate hydrate is studied via two-time oxygen-17 stimulated-echo correlation functions. The resulting correlationmore » times and those of hexagonal ice are similar to those from previous deuteron NMR measurements. Calculations of the echo functions’ final-state correlations for various motional models are compared with the experimental data of the clathrate hydrate. It is found that a six-site model including the oxygen-proton dipolar interaction describes the present results.« less

Unit-Sphere Multiaxial Stochastic-Strength Model Applied to Anisotropic and Composite Materials

NASA Technical Reports Server (NTRS)

Nemeth, Noel, N.

2013-01-01

Models that predict the failure probability of brittle materials under multiaxial loading have been developed by authors such as Batdorf, Evans, and Matsuo. These "unit-sphere" models assume that the strength-controlling flaws are randomly oriented, noninteracting planar microcracks of specified geometry but of variable size. This methodology has been extended to predict the multiaxial strength response of transversely isotropic brittle materials, including polymer matrix composites (PMCs), by considering (1) flaw-orientation anisotropy, whereby a preexisting microcrack has a higher likelihood of being oriented in one direction over another direction, and (2) critical strength, or K (sub Ic) orientation anisotropy, whereby the level of critical strength or fracture toughness for mode I crack propagation, K (sub Ic), changes with regard to the orientation of the microstructure. In this report, results from finite element analysis of a fiber-reinforced-matrix unit cell were used with the unit-sphere model to predict the biaxial strength response of a unidirectional PMC previously reported from the World-Wide Failure Exercise. Results for nuclear-grade graphite materials under biaxial loading are also shown for comparison. This effort was successful in predicting the multiaxial strength response for the chosen problems. Findings regarding stress-state interactions and failure modes also are provided.

Weak Broadband Electromagnetic Fields are More Disruptive to Magnetic Compass Orientation in a Night-Migratory Songbird (Erithacus rubecula) than Strong Narrow-Band Fields

PubMed Central

Schwarze, Susanne; Schneider, Nils-Lasse; Reichl, Thomas; Dreyer, David; Lefeldt, Nele; Engels, Svenja; Baker, Neville; Hore, P. J.; Mouritsen, Henrik

2016-01-01

Magnetic compass orientation in night-migratory songbirds is embedded in the visual system and seems to be based on a light-dependent radical pair mechanism. Recent findings suggest that both broadband electromagnetic fields ranging from ~2 kHz to ~9 MHz and narrow-band fields at the so-called Larmor frequency for a free electron in the Earth’s magnetic field can disrupt this mechanism. However, due to local magnetic fields generated by nuclear spins, effects specific to the Larmor frequency are difficult to understand considering that the primary sensory molecule should be organic and probably a protein. We therefore constructed a purpose-built laboratory and tested the orientation capabilities of European robins in an electromagnetically silent environment, under the specific influence of four different oscillating narrow-band electromagnetic fields, at the Larmor frequency, double the Larmor frequency, 1.315 MHz or 50 Hz, and in the presence of broadband electromagnetic noise covering the range from ~2 kHz to ~9 MHz. Our results indicated that the magnetic compass orientation of European robins could not be disrupted by any of the relatively strong narrow-band electromagnetic fields employed here, but that the weak broadband field very efficiently disrupted their orientation. PMID:27047356

The dynamic three-dimensional organization of the diploid yeast genome

PubMed Central

Kim, Seungsoo; Liachko, Ivan; Brickner, Donna G; Cook, Kate; Noble, William S; Brickner, Jason H; Shendure, Jay; Dunham, Maitreya J

2017-01-01

The budding yeast Saccharomyces cerevisiae is a long-standing model for the three-dimensional organization of eukaryotic genomes. However, even in this well-studied model, it is unclear how homolog pairing in diploids or environmental conditions influence overall genome organization. Here, we performed high-throughput chromosome conformation capture on diverged Saccharomyces hybrid diploids to obtain the first global view of chromosome conformation in diploid yeasts. After controlling for the Rabl-like orientation using a polymer model, we observe significant homolog proximity that increases in saturated culture conditions. Surprisingly, we observe a localized increase in homologous interactions between the HAS1-TDA1 alleles specifically under galactose induction and saturated growth. This pairing is accompanied by relocalization to the nuclear periphery and requires Nup2, suggesting a role for nuclear pore complexes. Together, these results reveal that the diploid yeast genome has a dynamic and complex 3D organization. DOI: http://dx.doi.org/10.7554/eLife.23623.001 PMID:28537556

Shugoshins function as a guardian for chromosomal stability in nuclear division.

PubMed

Yao, Yixin; Dai, Wei

2012-07-15

Accurate chromosome segregation during mitosis and meiosis is regulated and secured by several distinctly different yet intricately connected regulatory mechanisms. As chromosomal instability is a hallmark of a majority of tumors as well as a cause of infertility for germ cells, extensive research in the past has focused on the identification and characterization of molecular components that are crucial for faithful chromosome segregation during cell division. Shugoshins, including Sgo1 and Sgo2, are evolutionarily conserved proteins that function to protect sister chromatid cohesion, thus ensuring chromosomal stability during mitosis and meiosis in eukaryotes. Recent studies reveal that Shugoshins in higher animals play an essential role not only in protecting centromeric cohesion of sister chromatids and assisting bi-orientation attachment at the kinetochores, but also in safeguarding centriole cohesion/engagement during early mitosis. Many molecular components have been identified that play essential roles in modulating/mediating Sgo functions. This review primarily summarizes recent advances on the mechanisms of action of Shugoshins in suppressing chromosomal instability during nuclear division in eukaryotic organisms.

Self organizing map neural networks approach for lithologic interpretation of nuclear and electrical well logs in basaltic environment, Southern Syria.

PubMed

Asfahani, J; Ahmad, Z; Ghani, B Abdul

2018-07-01

An approach based on self organizing map (SOM) artificial neural networks is proposed herewith oriented towards interpreting nuclear and electrical well logging data. The well logging measurements of Kodana well in Southern Syria have been interpreted by applying the proposed approach. Lithological cross-section model of the basaltic environment has been derived and four different kinds of basalt have been consequently distinguished. The four basalts are hard massive basalt, hard basalt, pyroclastic basalt and the alteration basalt products- clay. The results obtained by SOM artificial neural networks are in a good agreement with the previous published results obtained by other different techniques. The SOM approach is practiced successfully in the case study of the Kodana well logging data, and can be therefore recommended as a suitable and effective approach for handling huge well logging data with higher number of variables required for lithological discrimination purposes. Copyright © 2018 Elsevier Ltd. All rights reserved.

Reliability assessment of MVP-BURN and JENDL-4.0 related to nuclear transmutation of light platinum group elements

NASA Astrophysics Data System (ADS)

Terashima, Atsunori; Nilsson, Mikael; Ozawa, Masaki; Chiba, Satoshi

2017-09-01

The Aprés ORIENT research program, as a concept of advanced nuclear fuel cycle, was initiated in FY2011 aiming at creating stable, highly-valuable elements by nuclear transmutation from ↓ssion products. In order to simulate creation of such elements by (n, γ) reaction succeeded by β- decay in reactors, a continuous-energy Monte Carlo burnup calculation code MVP-BURN was employed. Then, it is one of the most important tasks to con↓rm the reliability of MVP-BURN code and evaluated neutron cross section library. In this study, both an experiment of neutron activation analysis in TRIGA Mark I reactor at University of California, Irvine and the corresponding burnup calculation using MVP-BURN code were performed for validation of the simulation on transmutation of light platinum group elements. Especially, some neutron capture reactions such as 102Ru(n, γ)103Ru, 104Ru(n, γ)105Ru, and 108Pd(n, γ)109Pd were dealt with in this study. From a comparison between the calculation (C) and the experiment (E) about 102Ru(n, γ)103Ru, the deviation (C/E-1) was signi↓cantly large. Then, it is strongly suspected that not MVP-BURN code but the neutron capture cross section of 102Ru belonging to JENDL-4.0 used in this simulation have made the big di↑erence as (C/E-1) >20%.

Capabilities of GRO/OSSE for observing solar flares

NASA Technical Reports Server (NTRS)

Kurfess, J. D.; Johnson, W. N.; Share, G. H.; Hulburt, E. O.; Matz, S. M.; Murphy, R. J.

1989-01-01

The launch of the Gamma Ray Observatory (GRO) near solar maximum makes solar flare studies early in the mission particularly advantageous. The Oriented Scintillation Spectrometer Experiment (OSSE) on GRO, covering the energy range 0.05 to 150 MeV, has some significant advantages over the previous generation of satellite-borne gamma-ray detectors for solar observations. The OSSE detectors will have about 10 times the effective area of the Gamma-Ray Spectrometer (GRS) on Solar Maximum Mission (SMM) for both photons and high-energy neutrons. The OSSE also has the added capability of distinguishing between high-energy neutrons and photons directly. The OSSE spectral accumulation time (approx. 4s) is four times faster than that of the SMM/GRS; much better time resolution is available in selected energy ranges. These characteristics will allow the investigation of particle acceleration in flares based on the evolution of the continuum and nuclear line components of flare spectra, nuclear emission in small flares, the anisotropy of continuum emission in small flares, and the relative intensities of different nuclear lines. The OSSE observational program will be devoted primarily to non-solar sources. Therefore, solar observations require planning and special configurations. The instrumental and operational characteristics of OSSE are discussed in the context of undertaking solar observations. The opportunities for guest investigators to participate in solar flare studies with OSSE is also presented.

Consequences of the nuclear power plant accident at Chernobyl.

PubMed Central

Ginzburg, H M; Reis, E

1991-01-01

The Chernobyl Nuclear Power Plant accident, in the Ukrainian Soviet Socialist Republic (SSR), on April 26, 1986, was the first major nuclear power plant accident that resulted in a large-scale fire and subsequent explosions, immediate and delayed deaths of plant operators and emergency service workers, and the radioactive contamination of a significant land area. The release of radioactive material, over a 10-day period, resulted in millions of Soviets, and other Europeans, being exposed to measurable levels of radioactive fallout. Because of the effects of wind and rain, the radioactive nuclide fallout distribution patterns are not well defined, though they appear to be focused in three contiguous Soviet Republics: the Ukrainian SSR, the Byelorussian SSR, and the Russian Soviet Federated Socialist Republic. Further, because of the many radioactive nuclides (krypton, xenon, cesium, iodine, strontium, plutonium) released by the prolonged fires at Chernobyl, the long-term medical, psychological, social, and economic effects will require careful and prolonged study. Specifically, studies on the medical (leukemia, cancers, thyroid disease) and psychological (reactive depressions, post-traumatic stress disorders, family disorganization) consequences of continued low dose radiation exposure in the affected villages and towns need to be conducted so that a coherent, comprehensive, community-oriented plan may evolve that will not cause those already affected any additional harm and confusion. Images p38-a p38-b PMID:1899937

Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 4. Warning, Emergency Operations, and Support Programs.

ERIC Educational Resources Information Center

Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

The need for, and a description of, emergency functions required to save lives and protect property in nuclear or natural disasters are presented. Topics discussed include: (1) The Civil Defense Warning System, (2) Introduction to the Emergency Operations Program, (3) Five subprograms of the Emergency Operations Program, (4) Emergency Operations…

Semiquantitative Multiplexed Tandem PCR for Detection and Differentiation of Four Theileria orientalis Genotypes in Cattle

PubMed Central

Perera, Piyumali K.; Gasser, Robin B.; Firestone, Simon M.; Smith, Lee; Roeber, Florian

2014-01-01

Oriental theileriosis is an emerging, tick-borne disease of bovines in the Asia-Pacific region and is caused by one or more genotypes of the Theileria orientalis complex. This study aimed to establish and validate a multiplexed tandem PCR (MT-PCR) assay using three distinct markers (major piroplasm surface protein, 23-kDa piroplasm membrane protein, and the first internal transcribed spacer of nuclear DNA), for the simultaneous detection and semiquantification of four genotypes (Buffeli, Chitose, Ikeda, and type 5) of the T. orientalis complex. Analytical specificity, analytical sensitivity, and repeatability of the established MT-PCR assay were assessed in a series of experiments. Subsequently, the assay was evaluated using 200 genomic DNA samples collected from cattle from farms on which oriental theileriosis outbreaks had occurred, and 110 samples from a region where no outbreaks had been reported. The results showed the MT-PCR assay specifically and reproducibly detected the expected genotypes (i.e., genotypes Buffeli, Chitose, Ikeda, and type 5) of the T. orientalis complex, reliably differentiated them, and was able to detect as little as 1 fg of genomic DNA from each genotype. The diagnostic specificity and sensitivity of the MT-PCR were estimated at 94.0% and 98.8%, respectively. The MT-PCR assay established here is a practical and effective diagnostic tool for the four main genotypes of T. orientalis complex in Australia and should assist studies of the epidemiology and pathophysiology of oriental theileriosis in the Asia-Pacific region. PMID:25339402

Triple Differential Cross Sections for single ionization of the Ethane molecule

NASA Astrophysics Data System (ADS)

Ali, Esam; Nixon, Kate; Ning, Chuangang; Murray, Andrew; Madison, Don

2015-09-01

We report experimental and theoretical results for electron-impact (e,2e) ionization of the Ethane molecule (C2H6) in the coplanar scattering geometry for four different ejected electron energies Ea = 5,10,15, and 20 eV respectively, and for each ejected electron energy, the projectile scattering angle is fixed at 10°. We will show that the TDCS is very sensitive for the case of two heavy nuclei surrounded by lighter H nuclei. On the theoretical side, we have used the M3DW coupled with the Orientation Averaged Molecular Orbital (OAMO) approximation and proper average (PA) over all orientations. These approximations show good agreement with experimental data for the binary peaks. However, for the recoil peak region, experiment finds a noticeable peak while theory predicts no peak. No recoil peak suggests no (or very weak) nuclear scattering, so we have investigated the importance of nuclear scattering by moving the nuclei closer to the center of mass. This work is supported by the US National Science Foundation under Grant No. PHY-1068237 and XSEDE resources provided by the Texas Advanced Computing Center (Grant No. TG-MCA07S029).

Nuclear magnetic moment of {sup 69}As from on-line {beta}-NMR on oriented nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Golovko, V.V.; Kraev, I.S.; Phalet, T.

2005-12-15

A precise value for the magnetic moment of the {sup 69}As 5/2{sup -} ground state has been obtained from nuclear magnetic resonance on oriented nuclei (NMR/ON) using the NICOLE {sup 3}He-{sup 4}He dilution refrigerator setup at ISOLDE/CERN. The NMR/ON signal was observed by monitoring the anisotropy of the {sup 69}As {beta} particles. The center frequency {nu}[B{sub ext}=0.0994(10)T]=169.98(9) MHz corresponds to {mu}[{sup 69}As]=+1.6229(16){mu}{sub N}. This result differs considerably from the {pi}f{sub 5/2} single-particle value obtained with g factors for a free proton but is in reasonable agreement with the value obtained with effective g factors and with values from a coremore » polarization calculation and from calculations in the framework of the interacting boson-fermion model. Assuming a single exponential spin-lattice relaxation behavior a relaxation time T{sub 1}{sup '}=10(25) s was observed for {sup 69}AsFe{sub -bar} at a temperature of about 20 mK in a magnetic field B=0.1 T.« less

Isolation driven divergence: speciation in a widespread North American songbird (Aves: Certhiidae)

PubMed Central

Manthey, Joseph D.; Klicka, John; Spellman, Garth M.

2011-01-01

Lineage, or true “species,” trees may differ from gene trees because of stochastic processes in molecular evolution leading to gene-tree heterogeneity. Problems with inferring species trees due to excessive incomplete lineage sorting may be exacerbated in lineages with rapid diversification or recent divergences necessitating the use of multiple loci and individuals. Many recent multilocus studies that investigate divergence times identify lineage splitting to be more recent than single locus studies, forcing the revision of biogeographic scenarios driving divergence. Here we use 21 nuclear loci from regional populations to reevaluate hypotheses identified in an mtDNA phylogeographic study of the Brown Creeper (Certhia americana), as well as identify processes driving divergence. Nuclear phylogeographic analyses identified hierarchical genetic structure, supporting a basal split at roughly 32°N latitude, splitting northern and southern populations, with mixed patterns of genealogical concordance and discordance between datasets within the major lineages. Coalescent-based analyses identify isolation, with little to no gene flow, as the primary driver of divergence between lineages. Recent isolation appears to have caused genetic bottlenecks in populations in the Sierra Madre Oriental and coastal mountain ranges of California, which may be targets for conservation concerns. PMID:21933295

Properties of a U1 RNA enhancer-like sequence.

PubMed Central

Ciliberto, G; Palla, F; Tebb, G; Mattaj, I W; Philipson, L

1987-01-01

The properties of a X.laevis U1B snRNA gene enhancer have been studied by microinjection in Xenopus oocytes. The enhancer-like sequence, defined as a short DNA stretch that is able to activate transcription in an orientation independent manner, is interchangeable between different U snRNA genes. The enhancer sequence alone does not, however, efficiently activate transcription from an SV40 pol II promoter but regains its activity when combined with the U-gene specific proximal sequence element. DNase I protection experiments show that the X.laevis U1B enhancer can interact specifically with a nuclear factor present in mammalian cells. Images PMID:3031597

In-beam Fission Study at JAEA

NASA Astrophysics Data System (ADS)

Nishio, Katsuhisa

2013-12-01

Fission fragment mass distributions were measured in heavy-ion induced fissions using 238U target nucleus. The measured mass distributions changed drastically with incident energy. The results are explained by a change of the ratio between fusion and quasifission with nuclear orientation. A calculation based on a fluctuation dissipation model reproduced the mass distributions and their incident energy dependence. Fusion probability was determined in the analysis. Evaporation residue cross sections were calculated with a statistical model in the reactions of 30Si + 238U and 34S + 238U using the obtained fusion probability in the entrance channel. The results agree with the measured cross sections for seaborgium and hassium isotopes.

In-beam fission study for Heavy Element Synthesis

NASA Astrophysics Data System (ADS)

Nishio, Katsuhisa

2013-12-01

Fission fragment mass distributions were measured in heavy-ion induced fissions using 238U target nucleus. The measured mass distributions changed drastically with incident energy. The results are explained by a change of the ratio between fusion and qasifission with nuclear orientation. A calculation based on a fluctuation dissipation model reproduced the mass distributions and their incident energy dependence. Fusion probability was determined in the analysis. Evaporation residue cross sections were calculated with a statistical model in the reactions of 30Si + 238U and 34S + 238U using the obtained fusion probability in the entrance channel. The results agree with the measured cross sections for seaborgium and hassium isotopes.

A Literature Review and Compilation of Nuclear Waste Management System Attributes for Use in Multi-Objective System Evaluations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalinina, Elena Arkadievna; Samsa, Michael

The purpose of this work was to compile a comprehensive initial set of potential nuclear waste management system attributes. This initial set of attributes is intended to serve as a starting point for additional consideration by system analysts and planners to facilitate the development of a waste management system multi-objective evaluation framework based on the principles and methodology of multi-attribute utility analysis. The compilation is primarily based on a review of reports issued by the Canadian Nuclear Waste Management Organization (NWMO) and the Blue Ribbon Commission on America's Nuclear Future (BRC), but also an extensive review of the available literaturemore » for similar and past efforts as well. Numerous system attributes found in different sources were combined into a single objectives-oriented hierarchical structure. This study provides a discussion of the data sources and the descriptions of the hierarchical structure. A particular focus of this study was on collecting and compiling inputs from past studies that involved the participation of various external stakeholders. However, while the important role of stakeholder input in a country's waste management decision process is recognized in the referenced sources, there are only a limited number of in-depth studies of the stakeholders' differing perspectives. Compiling a comprehensive hierarchical listing of attributes is a complex task since stakeholders have multiple and often conflicting interests. The BRC worked for two years (January 2010 to January 2012) to "ensure it has heard from as many points of view as possible." The Canadian NWMO study took four years and ample resources, involving national and regional stakeholders' dialogs, internet-based dialogs, information and discussion sessions, open houses, workshops, round tables, public attitude research, website, and topic reports. The current compilation effort benefited from the distillation of these many varied inputs conducted by the previous studies.« less

Dynamic nuclear polarization methods in solids and solutions to explore membrane proteins and membrane systems.

PubMed

Cheng, Chi-Yuan; Han, Songi

2013-01-01

Membrane proteins regulate vital cellular processes, including signaling, ion transport, and vesicular trafficking. Obtaining experimental access to their structures, conformational fluctuations, orientations, locations, and hydration in membrane environments, as well as the lipid membrane properties, is critical to understanding their functions. Dynamic nuclear polarization (DNP) of frozen solids can dramatically boost the sensitivity of current solid-state nuclear magnetic resonance tools to enhance access to membrane protein structures in native membrane environments. Overhauser DNP in the solution state can map out the local and site-specific hydration dynamics landscape of membrane proteins and lipid membranes, critically complementing the structural and dynamics information obtained by electron paramagnetic resonance spectroscopy. Here, we provide an overview of how DNP methods in solids and solutions can significantly increase our understanding of membrane protein structures, dynamics, functions, and hydration in complex biological membrane environments.

Scale models: A proven cost-effective tool for outage planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, R.; Segroves, R.

1995-03-01

As generation costs for operating nuclear stations have risen, more nuclear utilities have initiated efforts to improve cost effectiveness. Nuclear plant owners are also being challenged with lower radiation exposure limits and new revised radiation protection related regulations (10 CFR 20), which places further stress on their budgets. As source term reduction activities continue to lower radiation fields, reducing the amount of time spent in radiation fields becomes one of the most cost-effective ways of reducing radiation exposure. An effective approach for minimizing time spent in radiation areas is to use a physical scale model for worker orientation planning andmore » monitoring maintenance, modifications, and outage activities. To meet the challenge of continued reduction in the annual cumulative radiation exposures, new cost-effective tools are required. One field-tested and proven tool is the physical scale model.« less

New Brunswick Laboratory: Progress report, October 1993 through September 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The mission of the New Brunswick Laboratory of the US Department of Energy (DOE) is to serve as the National Certifying Authority for nuclear reference materials and to provide an independent Federal technical staff and laboratory resource performing nuclear material measurement, safeguards and non-proliferation functions in support of multiple program sponsors. During FY 94 New Brunswick Laboratory (NBL) completed development of a Strategic Plan which will aid in better defining performance oriented laboratory goals and objectives in each functional area consistent with the changing needs of the global nuclear community. This annual report describes accomplishments achieved in carrying out NBL`smore » assigned missions. Details of completed projects are reported in separate topical reports or as open-literature publications. Programs discussed here are: (1) safeguards assistance; (2) reference materials program; (3) measurement evaluation; (4) measurement services; and (5) measurement development.« less

Electron quantum dynamics in atom-ion interaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sabzyan, H., E-mail: sabzyan@sci.ui.ac.ir; Jenabi, M. J.

2016-04-07

Electron transfer (ET) process and its dependence on the system parameters are investigated by solving two-dimensional time-dependent Schrödinger equation numerically using split operator technique. Evolution of the electron wavepacket occurs from the one-electron species hydrogen atom to another bare nucleus of charge Z > 1. This evolution is quantified by partitioning the simulation box and defining regional densities belonging to the two nuclei of the system. It is found that the functional form of the time-variations of these regional densities and the extent of ET process depend strongly on the inter-nuclear distance and relative values of the nuclear charges, whichmore » define the potential energy surface governing the electron wavepacket evolution. Also, the initial electronic state of the single-electron atom has critical effect on this evolution and its consequent (partial) electron transfer depending on its spreading extent and orientation with respect to the inter-nuclear axis.« less

Micronuclei and other erythrocyte nuclear abnormalities in fishes from the Great Lakes Basin, USA.

PubMed

Braham, Ryan P; Blazer, Vicki S; Shaw, Cassidy H; Mazik, Patricia M

2017-10-01

Biological markers (biomarkers) sensitive to genotoxic and mutagenic contamination in fishes are widely used to identify exposure effects in aquatic environments. The micronucleus assay was incorporated into a suite of indicators to assess exposure to genotoxic and mutagenic contamination at five Great Lakes Areas of Concern (AOCs), as well as one non-AOC (reference) site. The assay allowed enumeration of micronuclei as well as other nuclear abnormalities for both site and species comparisons. Erythrocyte abnormality data was also compared to skin and liver tumor prevalence and hepatic transcript abundance. Erythrocyte abnormalities were observed at all sites with variable occurrence and severity among sites and species. Benthic-oriented brown bullhead (Ameiurus nebulosus) and white sucker (Catostomus commersonii) expressed lower rates of erythrocyte abnormalities, but higher rates of skin and liver neoplasms, when compared to pelagic-oriented largemouth bass (Micropterus salmoides) or smallmouth bass (Micropterus dolomieu) at the same site. The reduced erythrocyte abnormalities, increased transcript abundance associated with Phase I and II toxicant responsive pathways, and increased neoplastic lesions among benthic-oriented taxa may indicate the development of contaminant resistance of these species to more acute effects. Environ. Mol. Mutagen. 58:570-581, 2017. © 2017 This article is a U.S. Government work and is in the public domain in the USA. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society. © 2017 This article is a U.S. Government work and is in the public domain in the USA. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society.

Giant titanium electron wave function in gallium oxide: A potential electron-nuclear spin system for quantum information processing

NASA Astrophysics Data System (ADS)

Mentink-Vigier, Frédéric; Binet, Laurent; Vignoles, Gerard; Gourier, Didier; Vezin, Hervé

2010-11-01

The hyperfine interactions of the unpaired electron with eight surrounding G69a and G71a nuclei in Ti-doped β-Ga2O3 were analyzed by electron paramagnetic resonance (EPR) and electron-nuclear double resonance (ENDOR) spectroscopies. They are dominated by strong isotropic hyperfine couplings due to a direct Fermi contact interaction with Ga nuclei in octahedral sites of rutile-type chains oriented along b axis, revealing a large anisotropic spatial extension of the electron wave function. Titanium in β-Ga2O3 is thus best described as a diffuse (Ti4+-e-) pair rather than as a localized Ti3+ . Both electron and G69a nuclear spin Rabi oscillations could be observed by pulsed EPR and pulsed ENDOR, respectively. The electron spin decoherence time is about 1μs (at 4 K) and an upper bound of 520μs (at 8 K) is estimated for the nuclear decoherence time. Thus, β-Ga2O3:Ti appears to be a potential spin-bus system for quantum information processing with a large nuclear spin quantum register.

Nuclear fluxes during coherent tunnelling in asymmetric double well potentials

NASA Astrophysics Data System (ADS)

Liu, ChunMei; Manz, Jörn; Yang, Yonggang

2015-08-01

Previous results for nuclear fluxes during coherent tunnelling of molecules with symmetric double well potentials are extended to fluxes in asymmetric double well potentials. The theory is derived using the two-state approximation (TSA). The symmetric system serves as a reference. As an example, we consider the one-dimensional model of the tunnelling inversion of oriented ammonia, with semiclassical dipole coupling to an electric field. The tunnelling splitting increases with the dipole coupling by a factor f≥slant 1. The tunnelling time decreases by 1/f. The nuclear density appears as the sum of two parts: The tunnelling part decreases as {1/f}2 times the density of the symmetric reference, whereas the non-tunnelling part is the initial density times ≤ft({{1-1}/f}2\\right). Likewise, the nuclear flux decreases by 1/f, with essentially the same shape as for the symmetric reference, with maximum value at the potential barrier. Coherent nuclear tunnellings starting from the upper or lower wells of the asymmetric potential are equivalent. The results are universal, in the frame of the TSA, hence they allow straightforward extrapolations from one system to others. This is demonstrated by the prediction of isotope effects for five isotopomers of ammonia.

Computerized morphometry as an aid in distinguishing recurrent versus nonrecurrent meningiomas.

PubMed

Noy, Shawna; Vlodavsky, Euvgeni; Klorin, Geula; Drumea, Karen; Ben Izhak, Ofer; Shor, Eli; Sabo, Edmond

2011-06-01

To use novel digital and morphometric methods to identify variables able to better predict the recurrence of intracranial meningiomas. Histologic images from 30 previously diagnosed meningioma tumors that recurred over 10 years of follow-up were consecutively selected from the Rambam Pathology Archives. Images were captured and morphometrically analyzed. Novel algorithms of digital pattern recognition using Fourier transformation and fractal and nuclear texture analyses were applied to evaluate the overall growth pattern complexity of the tumors, as well as the chromatin texture of individual tumor nuclei. The extracted parameters were then correlated with patient prognosis. Kaplan-Meier analyses revealed statistically significant associations between tumor morphometric parameters and recurrence times. Tumors with less nuclear orientation, more nuclear density, higher fractal dimension, and less regular chromatin textures tended to recur faster than those with a higher degree of nuclear order, less pattern complexity, lower density, and more homogeneous chromatin nuclear textures (p < 0.01). To our knowledge, these digital morphometric methods were used for the first time to accurately predict tumor recurrence in patients with intracranial meningiomas. The use of these methods may bring additional valuable information to the clinician regarding the optimal management of these patients.

Transient nutation electron spin resonance spectroscopy on spin-correlated radical pairs: A theoretical analysis on hyperfine-induced nuclear modulations

NASA Astrophysics Data System (ADS)

Weber, Stefan; Kothe, Gerd; Norris, James R.

1997-04-01

The influence of anisotropic hyperfine interaction on transient nutation electron paramagnetic resonance (EPR) of light-induced spin-correlated radical pairs is studied theoretically using the density operator formalism. Analytical expressions for the time evolution of the transient EPR signal during selective microwave excitation of single transitions are derived for a model system comprised of a weakly coupled radical pair and one hyperfine-coupled nucleus with I=1/2. Zero-quantum electron coherence and single-quantum nuclear coherence are created as a result of the sudden light-induced generation of the radical pair state from a singlet-state precursor. Depending on the relative sizes of the nuclear Zeeman frequency and the secular and pseudo-secular parts of the hyperfine coupling, transitions between levels with different nuclear spin orientations are predicted to modulate the time-dependent EPR signal. These modulations are in addition to the well-known transient nutations and electron zero-quantum precessions. Our calculations provide insight into the mechanism of recent experimental observations of coherent nuclear modulations in the time-resolved EPR signals of doublets and radical pairs. Two distinct mechanisms of the modulations are presented for various microwave magnetic field strengths. The first modulation scheme arises from electron and nuclear coherences initiated by the laser excitation pulse and is "read out" by the weak microwave magnetic field. While the relative modulation depth of these oscillations with respect to the signal intensity is independent of the Rabi frequency, ω1, the frequencies of this coherence phenomenon are modulated by the effective microwave amplitude and determined by the nuclear Zeeman interaction and hyperfine coupling constants as well as the electron-electron spin exchange and dipolar interactions between the two radical pair halves. In a second mechanism the modulations are both created and detected by the microwave radiation. Here, the laser pulse merely defines the beginning of the microwave-induced coherent time evolution. This second mechanism appears the most consistent with current experimental observations.

Stopping effects in U+U collisions with a beam energy of 520 MeV/nucleon

NASA Astrophysics Data System (ADS)

Luo, Xiao-Feng; Dong, Xin; Shao, Ming; Wu, Ke-Jun; Li, Cheng; Chen, Hong-Fang; Xu, Hu-Shan

2007-10-01

A relativistic transport model (ART1.0) is applied to simulate the stopping effects in tip-tip and body-body U+U collisions, at a beam kinetic energy of 520 MeV/nucleon. Our simulation results have demonstrated that both central collisions of the two extreme orientations can achieve full stopping and also form a bulk of hot, dense nuclear matter with a sufficiently large volume and long duration, because of the largely deformed uranium nuclei. The nucleon sideward flow in the tip-tip collisions is nearly three times larger than that in body-body ones at the normalized impact parameter b/bmax<0.5, and that the body-body central collisions have a large negative nucleon elliptic flow v2=-12% in contrast to zero in tip-tip ones. Thus the extreme circumstance and the novel experimental observables in tip-tip and body-body collisions can provide a good condition and sensitive probe for studying the nuclear EoS, respectively. The cooling storage ring (CSR) external target facility (ETF) to be built at Lanzhou, China, delivering a uranium beam up to 520 MeV/nucleon is expected to make a significant contribution to exploring the nuclear equation of state (EoS).

Large-Scale Weibull Analysis of H-451 Nuclear- Grade Graphite Specimen Rupture Data

NASA Technical Reports Server (NTRS)

Nemeth, Noel N.; Walker, Andrew; Baker, Eric H.; Murthy, Pappu L.; Bratton, Robert L.

2012-01-01

A Weibull analysis was performed of the strength distribution and size effects for 2000 specimens of H-451 nuclear-grade graphite. The data, generated elsewhere, measured the tensile and four-point-flexure room-temperature rupture strength of specimens excised from a single extruded graphite log. Strength variation was compared with specimen location, size, and orientation relative to the parent body. In our study, data were progressively and extensively pooled into larger data sets to discriminate overall trends from local variations and to investigate the strength distribution. The CARES/Life and WeibPar codes were used to investigate issues regarding the size effect, Weibull parameter consistency, and nonlinear stress-strain response. Overall, the Weibull distribution described the behavior of the pooled data very well. However, the issue regarding the smaller-than-expected size effect remained. This exercise illustrated that a conservative approach using a two-parameter Weibull distribution is best for designing graphite components with low probability of failure for the in-core structures in the proposed Generation IV (Gen IV) high-temperature gas-cooled nuclear reactors. This exercise also demonstrated the continuing need to better understand the mechanisms driving stochastic strength response. Extensive appendixes are provided with this report to show all aspects of the rupture data and analytical results.

Experiment S009: Nuclear Emulsion

NASA Technical Reports Server (NTRS)

Odell, F. W.; Shapiro, M. M.; Silberberg, R.; Stiller, B.; Tsao, C. H.; Durgaprasad, N.; Fichtel, C. E.; Guss, D. E.; Reames, D. V.

1971-01-01

The first exposure on a spacecraft of a nuclear emulsion apparatus designed to collect 1000 high quality tracks of heavy nuclei under a negligible thickness of matter (0.07 g/sq cm) is described. The cosmic ray detector consisted of a stack of nuclear emulsions that were designed to register at least 400 heavy nuclei tracks for each 10 hours of useful exposure. The spacecraft had to be oriented in a heads-up attitude during the 10-hour period to eliminate atmospheric albedo particles. The results are as follows: (1) a definite odd-even effect, with low abundances for elements of atomic number 7, 9, and 11; (2) a ratio O/C approximately 0.9; (3) Ne/C, Mg/C, and Si/C ratios between 0.2 and 0.3; (4) an abundance gap in the region 15 less than or equal to Z less than or equal to 19; and (5) a ratio (20 less than or equal to Z less than or equal to 28)/C 0.2, with a large concentration at Z = 26. These results are indicative that successful exposures of nuclear emulsions were obtained on the Gemini 11 mission.

Beyond detection: nuclear physics with a webcam in an educational setting

NASA Astrophysics Data System (ADS)

Pallone, Arthur

2015-03-01

Nuclear physics affects our daily lives in such diverse fields from medicine to art. I believe three obstacles - limited time, lack of subject familiarity and thus comfort on the part of educators, and equipment expense - must be overcome to produce a nuclear-educated populace. Educators regularly use webcams to actively engage students in scientific discovery as evidenced by a literature search for the term webcam paired with topics such as astronomy, biology, and physics. Inspired by YouTube videos that demonstrate alpha particle detection by modified webcams, I searched for examples that go beyond simple detection with only one education-oriented result - the determination of the in-air range of alphas using a modified CCD camera. Custom-built, radiation-hardened CMOS detectors exist in high energy physics and for soft x-ray detection. Commercial CMOS cameras are used for direct imaging in electron microscopy. I demonstrate charged-particle spectrometry with a slightly modified CMOS-based webcam. When used with inexpensive sources of radiation and free software, the webcam charged-particle spectrometer presents educators with a simple, low-cost technique to include nuclear physics in science education.

New French Regulation for NPPs and Code Consequences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faidy, Claude

2006-07-01

On December 2005, the French regulator issued a new regulation for French nuclear power plants, in particular for pressure equipment (PE). This regulation need first to agree with non-nuclear PE regulation and add to that some specific requirements, in particular radiation protection requirements. Different advantages are in these proposal, it's more qualitative risk oriented and it's an important link with non-nuclear industry. Only few components are nuclear specific. But, the general philosophy of the existing Codes (RCC-M [15], KTA [16] or ASME [17]) have to be improved. For foreign Codes, it's plan to define the differences in the user specifications.more » In parallel to that, a new safety classification has been developed by French utility. The consequences is the need to cross all these specifications to define a minimum quality level for each components or systems. In the same time a new concept has been developed to replace the well known 'Leak Before Break methodology': the 'Break Exclusion' methodology. This paper will summarize the key aspects of these different topics. (authors)« less

Tourism Impacts of Three Mile Island and Other Adverse Events: Implications for Lincoln County and Other Rural Counties Bisected by Radioactive Wastes Intended for Yucca Mountain.

ERIC Educational Resources Information Center

Himmelberger, Jeffery J.; And Others

1995-01-01

Summarizes key research implications of Three Mile Island and other major hazard events as related to tourism. Examines how the proposed Yucca Mountain nuclear waste repository system will impact tourism in southern Nevada and other visitor-oriented rural counties bisected by planned waste transportation corridors. (AIM)

Structure of Cellulose Microfibrils in Primary Cell Walls from Collenchyma1[C][W][OA

PubMed Central

Thomas, Lynne H.; Forsyth, V. Trevor; Šturcová, Adriana; Kennedy, Craig J.; May, Roland P.; Altaner, Clemens M.; Apperley, David C.; Wess, Timothy J.; Jarvis, Michael C.

2013-01-01

In the primary walls of growing plant cells, the glucose polymer cellulose is assembled into long microfibrils a few nanometers in diameter. The rigidity and orientation of these microfibrils control cell expansion; therefore, cellulose synthesis is a key factor in the growth and morphogenesis of plants. Celery (Apium graveolens) collenchyma is a useful model system for the study of primary wall microfibril structure because its microfibrils are oriented with unusual uniformity, facilitating spectroscopic and diffraction experiments. Using a combination of x-ray and neutron scattering methods with vibrational and nuclear magnetic resonance spectroscopy, we show that celery collenchyma microfibrils were 2.9 to 3.0 nm in mean diameter, with a most probable structure containing 24 chains in cross section, arranged in eight hydrogen-bonded sheets of three chains, with extensive disorder in lateral packing, conformation, and hydrogen bonding. A similar 18-chain structure, and 24-chain structures of different shape, fitted the data less well. Conformational disorder was largely restricted to the surface chains, but disorder in chain packing was not. That is, in position and orientation, the surface chains conformed to the disordered lattice constituting the core of each microfibril. There was evidence that adjacent microfibrils were noncovalently aggregated together over part of their length, suggesting that the need to disrupt these aggregates might be a constraining factor in growth and in the hydrolysis of cellulose for biofuel production. PMID:23175754

Structure of cellulose microfibrils in primary cell walls from collenchyma.

PubMed

Thomas, Lynne H; Forsyth, V Trevor; Sturcová, Adriana; Kennedy, Craig J; May, Roland P; Altaner, Clemens M; Apperley, David C; Wess, Timothy J; Jarvis, Michael C

2013-01-01

In the primary walls of growing plant cells, the glucose polymer cellulose is assembled into long microfibrils a few nanometers in diameter. The rigidity and orientation of these microfibrils control cell expansion; therefore, cellulose synthesis is a key factor in the growth and morphogenesis of plants. Celery (Apium graveolens) collenchyma is a useful model system for the study of primary wall microfibril structure because its microfibrils are oriented with unusual uniformity, facilitating spectroscopic and diffraction experiments. Using a combination of x-ray and neutron scattering methods with vibrational and nuclear magnetic resonance spectroscopy, we show that celery collenchyma microfibrils were 2.9 to 3.0 nm in mean diameter, with a most probable structure containing 24 chains in cross section, arranged in eight hydrogen-bonded sheets of three chains, with extensive disorder in lateral packing, conformation, and hydrogen bonding. A similar 18-chain structure, and 24-chain structures of different shape, fitted the data less well. Conformational disorder was largely restricted to the surface chains, but disorder in chain packing was not. That is, in position and orientation, the surface chains conformed to the disordered lattice constituting the core of each microfibril. There was evidence that adjacent microfibrils were noncovalently aggregated together over part of their length, suggesting that the need to disrupt these aggregates might be a constraining factor in growth and in the hydrolysis of cellulose for biofuel production.

Strength and Anisotropy in Tournemire Shale: Temperature, Pressure and Time Dependences

NASA Astrophysics Data System (ADS)

Bonnelye, A.; Schubnel, A.; Zhi, G.; David, C.; Dick, P.

2017-12-01

Time and temperature dependent rock deformation has both scientific and socio-economic implications for natural hazards, the oil and gas industry and nuclear waste disposal. During the past decades, most studies on brittle creep have focused on igneous rocks and porous sedimentary rocks. To our knowledge, only few studies have been carried out on the brittle creep behavior of shale. We conducted a series of creep experiments on shale specimens coming from the French Institute for Nuclear Safety (IRSN) underground research laboratory located in Tournemire, France, under two different temperatures (26°C, 75°C) and confining pressures (10 MPa, 80 MPa), for three orientations (σ1along, perpendicular and 45° to bedding). In these long-term experiments (approximately 10 days), stress and strains were recorded continuously, while ultrasonic acoustic velocities were recorded every 1 15 minutes. The brittle creep failure stress of our Tournemire shale samples was systematically observed 50% higher than its short-term peak strength, with larger final axial strain accumulated. During creep, ultrasonic wave velocities first decreased, and then increased gradually. The magnitude of elastic wave velocity variations showed an important orientation and temperature dependence: velocities measured perpendicular to bedding showed increased variation, variation that was enhanced at higher temperature and higher pressure. The case of complete elastic anisotropy reversal was observed for sample deformed perpendicular to bedding, with amount of axial strain needed to reach anisotropy reversal reduced at higher temperature. SEM observations highlight the competition between crack growth, sealing/healing, and possibly mineral rotation, pressure solution or anisotropic compaction during creep defromation. Our study highlights that the short-term peak strength has little meaning in shale material, which can over-consolidate importantly by `plastic' flow. In addition, we show that elastic anisotropy can switch and even reverse over relatively short time periods (<10 days) and for relatively small amount of plastic deformation (<5%).

Verification of threshold activation detection (TAD) technique in prompt fission neutron detection using scintillators containing 19F

NASA Astrophysics Data System (ADS)

Sibczynski, P.; Kownacki, J.; Moszyński, M.; Iwanowska-Hanke, J.; Syntfeld-Każuch, A.; Gójska, A.; Gierlik, M.; Kaźmierczak, Ł.; Jakubowska, E.; Kędzierski, G.; Kujawiński, Ł.; Wojnarowicz, J.; Carrel, F.; Ledieu, M.; Lainé, F.

2015-09-01

In the present study ⌀ 5''× 3'' and ⌀ 2''× 2'' EJ-313 liquid fluorocarbon as well as ⌀ 2'' × 3'' BaF2 scintillators were exposed to neutrons from a 252Cf neutron source and a Sodern Genie 16GT deuterium-tritium (D+T) neutron generator. The scintillators responses to β- particles with maximum endpoint energy of 10.4 MeV from the n+19F reactions were studied. Response of a ⌀ 5'' × 3'' BC-408 plastic scintillator was also studied as a reference. The β- particles are the products of interaction of fast neutrons with 19F which is a component of the EJ-313 and BaF2 scintillators. The method of fast neutron detection via fluorine activation is already known as Threshold Activation Detection (TAD) and was proposed for photofission prompt neutron detection from fissionable and Special Nuclear Materials (SNM) in the field of Homeland Security and Border Monitoring. Measurements of the number of counts between 6.0 and 10.5 MeV with a 252Cf source showed that the relative neutron detection efficiency ratio, defined as epsilonBaF2 / epsilonEJ-313-5'', is 32.0% ± 2.3% and 44.6% ± 3.4% for front-on and side-on orientation of the BaF2, respectively. Moreover, the ⌀ 5'' EJ-313 and side-on oriented BaF2 were also exposed to neutrons from the D+T neutron generator, and the relative efficiency epsilonBaF2 / epsilonEJ-313-5'' was estimated to be 39.3%. Measurements of prompt photofission neutrons with the BaF2 detector by means of data acquisition after irradiation (out-of-beam) of nuclear material and between the beam pulses (beam-off) techniques were also conducted on the 9 MeV LINAC of the SAPHIR facility.

{sup 75}As NMR study of the oriented pnictide superconducting compound NdFeAsO{sub 0.83}F{sub 0.17}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pahari, Bholanath

Magnetization and {sup 75}As nuclear magnetic resonance (NMR) measurements in the superconductor NdFeAsO{sub 0.83}F{sub 0.17} (T{sub C}~46 K) are performed in order to investigate the effect of the Nd 4f electrons in the superconducting property. The magnetization curve displays a Nd 4f moments generated Curie-Weiss signal in the field of 7 T. {sup 75}As NMR spectra in the oriented sample (H{sub 0}‖ab) are recorded at 7 T in the temperature range 10–300 K and temperature dependent {sup 75}As NMR shift, K{sub ab} has been obtained. The K{sub ab} curve shows a Curie-Weiss type contribution. The magnitude of hyperfine field, H{submore » hf} (4.4 kOe/μ{sub B}) estimated from the K{sub ab} vs χ plot indicates a non-negligible RKKY-type interaction between localized Nd 4f moments mediated by itinerant Fe 3d electrons.« less

Estimatining biases in the stellar dynamical black hole mass measurements in barred galaxies and prospects for measuring SMBH masses with JWST

NASA Astrophysics Data System (ADS)

Valluri, Monica; Vasiliev, Eugene; Bentz, Misty; Shen, Juntai

2018-04-01

Although 60% of disk galaxies are barred, stellar dynamical measurements of the masses of supermassive black holes (SMBH) in barred galaxies have always been obtained under the assumption that the bulges are axisymmetric. We use N-body simulations with self-consistently grown SMBHs in barred and unbarred galaxies to create a suite of mock Integral Field Spectrographic (IFS) datasets for galaxies with various observed orientations. We then apply an axisymmetric orbit superposition code to these mock IFS datasets to assess the reliability with which SMBH masses can be recovered. We also assess which disk and bar orientations give rise to biases. We use these simulations to assess whether or not existing SMBH measurements in barred galaxies are likely to be biased. We also present a brief preview of our JWST Early Release Science proposal to study the nuclear dynamics of nearby Seyfert I galaxy NGC 4151 with the NIRSpec Integral Field Spectrograph and describe how simulations of disk galaxies will used to create mock NIRSpec data to prepare for the real data.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kadmensky, S. G., E-mail: kadmensky@phys.vsu.ru; Kostryukov, P. V.

It is shown that a quantum system whose Hamiltonian is independent of time is T -invariant if this Hamiltonian contains only those terms that do not change sign upon time reversal. It is also shown that the coincidence of the amplitudes for multistep direct and statistical nuclear reactions with the timereversed amplitudes for the reactions being studied is a condition that ensures the T -invariance of the amplitudes in question, the transition from the original amplitudes to their time-reversed counterparts being accomplished, first, upon introducing the inverse-reactionmatrices T instead of the original-reaction matrix T and, second, upon replacing the wavemore » functions for the initial, final, and intermediate states of the system by the respective time-reversed functions. It is found that the T -even (T -odd) asymmetries in cross sections for nuclear reactions stem from the interference between the amplitudes characterizing these reactions and having identical (opposite) T -parities. It is shown that the T -invariance condition for the above T -even (T -odd) asymmetries is related to the conservation of (change in) the sign of these asymmetries upon going over from original to inverse nuclear reactions. Mechanisms underlying the appearance of possible T -even and T-odd asymmetries in the cross sections for the cold-polarizedneutron- induced binary and ternary fission of oriented target nuclei are analyzed for the case of employing T -invariant Hamiltonians for the systems under study. It is also shown that the asymmetries in question satisfy the T -invariance condition if the reactions being considered have a sequential multistep statistical character. It is concluded that T -invariance is violated in the limiting case where, in ternary nuclear fission, the emission of a light third particle froma fissile compound nucleus formed upon incident-neutron capture by a target nucleus and its separation to two fission fragments are simultaneous events.« less

NMR studies of protein-nucleic acid interactions.

PubMed

Varani, Gabriele; Chen, Yu; Leeper, Thomas C

2004-01-01

Protein-DNA and protein-RNA complexes play key functional roles in every living organism. Therefore, the elucidation of their structure and dynamics is an important goal of structural and molecular biology. Nuclear magnetic resonance (NMR) studies of protein and nucleic acid complexes have common features with studies of protein-protein complexes: the interaction surfaces between the molecules must be carefully delineated, the relative orientation of the two species needs to be accurately and precisely determined, and close intermolecular contacts defined by nuclear Overhauser effects (NOEs) must be obtained. However, differences in NMR properties (e.g., chemical shifts) and biosynthetic pathways for sample productions generate important differences. Chemical shift differences between the protein and nucleic acid resonances can aid the NMR structure determination process; however, the relatively limited dispersion of the RNA ribose resonances makes the process of assigning intermolecular NOEs more difficult. The analysis of the resulting structures requires computational tools unique to nucleic acid interactions. This chapter summarizes the most important elements of the structure determination by NMR of protein-nucleic acid complexes and their analysis. The main emphasis is on recent developments (e.g., residual dipolar couplings and new Web-based analysis tools) that have facilitated NMR studies of these complexes and expanded the type of biological problems to which NMR techniques of structural elucidation can now be applied.

The reform of energy subsidies for the enhancement of marine sustainability: An empirical analysis of energy subsidies worldwide and an in-depth case study of South Korea's energy subsidy policies

NASA Astrophysics Data System (ADS)

Shim, Jae Hyun

This dissertation seeks to raise awareness about harmful effects of fossil fuel and nuclear energy subsidies that have blocked transition from conventional energy to a decarbonized, renewable energy system. Today, humans face daunting challenges in the form of global warming, which results mainly from the burning of fossil fuels. To avoid catastrophe, the transition to a renewable energy regime should be an urgent priority; however, the reality is that the progress of renewable energy is very slow due to the various political and economic factors when compared to conventional energy resources. A chief factor is that the energy subsidy for fossil fuel and nuclear energy obstructs the "level playing field" for renewable energy. Energy subsidies for conventional energy can be understood in the context of the commodification paradigm, which regards nature as an object of conquest and supports the principle of more is better. Although fossil fuel energy damages the environment, economy, and social equity, all countries subsidize such energy, no matter the country's state of development. This holds true as much in the U.S. and the EU as in China, India and South Korea. The oceans, which cover 71% of the earth, are threatened by the activities of conventional energy, which are underpinned by subsidies. These subsidies have contributed to the destruction of the marine ecosystem through increased GHG emissions like CO2 and NOx which cause a sea temperature increase and coral bleaching. Subsidies also significantly affect fishery overexploitation, oil pollution, and thermal pollution. In-depth empirical analysis of South Korea showed how fossil fuel and nuclear energy activities have threatened marine sustainability through thermal pollution, algae bloom (red tides), overexploitation, and oil-related marine pollution. Reforming subsidies of fossil fuel and nuclear energy should be a global priority because of imminent of global warming. As strategies for energy subsidy reforms, first of all, humans need a new energy paradigm to replace the hitherto dominant commodification paradigm. On an international level, creation of an international renewable energy agency and creation of renewable funds will spur on energy subsidy reforms of all nations, especially developing countries. On a national level, government's role should change from growth-oriented economic policy to sustainable development that includes environmentally friendly energy systems. In terms of social welfare, energy subsidies should be transformed to direct income policy, which is more effective for the welfare of the poor. The South Korean government should exchange its current supply-oriented fishery policy, which relies heavily on energy subsidies, to a Marine Reserves policy and direct income policy. For successful energy subsidy reforms, the government, NGOs, and private market should cooperate. Specifically, NGOs' role in monitoring and pushing government's energy subsidy reform is invaluable, considering the limits of modern bureaucracy and the profit-oriented market character. Most environmental problems, including global warming, have a close relation with fossil fuel and nuclear energy use. Historically, these energy systems have become entrenched deeply in society through energy subsidy policy. Energy subsidy reforms are a key to the environmental problem and accelerated transition to renewable energy.

The use of biomaterials for cell function enhancement: acceleration of fibroblast migration and promotion of stem cell proliferation

NASA Astrophysics Data System (ADS)

Qin, Sisi

Wound healing and tissue regeneration proceed via fibroblast migration along three dimensional scaffolds composed of fibers with different diameters, spacing, and junction angles. In order to understand how each of these factors influences fibroblast migration, a technique for preparation of three dimensional fibrillar scaffolds was developed where the fiber diameters and the angles between adjacent fiber layers could be precisely controlled. In order to study the en-mass migration process, the agarose droplet method was chosen since it enabled accurate determinations of the dependence of the migration speed, focal adhesion distribution, and nuclear deformation on the fiber structures. Results showed that on oriented single fiber layers, if the fiber diameters exceeded 1microm, large focal adhesion complexes formed in a linear arrangement along the fiber axis and cell motion was highly correlated. For fibers 1microm or less, some cell alignment along the fiber direction was measured, but no correlation between the distribution of focal adhesion points and fiber orientation was found. On multi layered scaffolds the focal adhesion sites were found to concentrate at the junction points and the migration speed followed a parabolic function with a distinct minimum at 35°. When compared to fibroblasts plated on 90° fibers, fibroblasts plated on 30° fibers showed a decrease of 25% in the degree of nuclear deformation and an increase of 25% in the number of focal adhesion sites, indicating that cell migration speed was correlated to the angle and distance of approach to the junction point. The time dependence of the migration velocity on oriented fibers was measured for four days and compared to the value measured on flat surfaces. After the initial 24 hour incubation period, the cells on both the 8microm fibers and flat surfaces migrated with a similar speed. During the next three days the migration speed for the cells on the fibrillar surfaces doubled in magnitude, while remained constant for the cells on the flat surfaces. The increased speed on the 8microm fiber surfaces could be correlated with a 20% increase in the nuclear deformation, and a decrease around 30% in the number of focal adhesion during the same observation period. RNA expression of Myosin IIA, a protein which complexes to the actin and is responsible for exertion of traction forces during migration was not upregulated during this process. On the other hand, histochemical staining of Myosin IIA showed that the protein had re-organized into large fibers which spanned the length of the cells. Observation of the cell morphology indicated that a new mode of motion had been established. Rather than the classical retraction of the cytoplasm followed by center of mass translation, which was observed on the flat surfaces, the cells were now moving by a contractile motion around the nucleus similar to that found in muscular motion. This mode was found to be more efficient when undergoing oriented motion. In addition to orientation, surface mechanics are also important in the tissue regeneration process. This study demonstrated that mechanical factors are important for the maintenance of pluripotency and control of proliferation rates. CD34+ hematopoietic stem cells (HSCs) were transduced with ICD (intracellular domain)-Notch and plated on gelatin hydrogels, whose moduli were controlled by the crosslinking ratio. On the softer hydrogel, a synergy was achieved which resulted in more than a five-fold increase in proliferation and a four-fold increase in the preservation of stemness, while HSCs maintained their ability to differentiate into multiple blood cell lineages. These results point the way for achieving clinically significant expansion of human HSCs.

Probing a chemical compass: novel variants of low-frequency reaction yield detected magnetic resonance.

PubMed

Maeda, Kiminori; Storey, Jonathan G; Liddell, Paul A; Gust, Devens; Hore, P J; Wedge, C J; Timmel, Christiane R

2015-02-07

We present a study of a carotenoid-porphyrin-fullerene triad previously shown to function as a chemical compass: the photogenerated carotenoid-fullerene radical pair recombines at a rate sensitive to the orientation of an applied magnetic field. To characterize the system we develop a time-resolved Low-Frequency Reaction Yield Detected Magnetic Resonance (tr-LF-RYDMR) technique; the effect of varying the relative orientation of applied static and 36 MHz oscillating magnetic fields is shown to be strongly dependent on the strength of the oscillating magnetic field. RYDMR is a diagnostic test for involvement of the radical pair mechanism in the magnetic field sensitivity of reaction rates or yields, and has previously been applied in animal behavioural experiments to verify the involvement of radical-pair-based intermediates in the magnetic compass sense of migratory birds. The spectroscopic selection rules governing RYDMR are well understood at microwave frequencies for which the so-called 'high-field approximation' is valid, but at lower frequencies different models are required. For example, the breakdown of the rotating frame approximation has recently been investigated, but less attention has so far been given to orientation effects. Here we gain physical insights into the interplay of the different magnetic interactions affecting low-frequency RYDMR experiments performed in the challenging regime in which static and oscillating applied magnetic fields as well as internal electron-nuclear hyperfine interactions are of comparable magnitude. Our observations aid the interpretation of existing RYDMR-based animal behavioural studies and will inform future applications of the technique to verify and characterize further the biological receptors involved in avian magnetoreception.

Applying AN Object-Oriented Database Model to a Scientific Database Problem: Managing Experimental Data at Cebaf.

NASA Astrophysics Data System (ADS)

Ehlmann, Bryon K.

Current scientific experiments are often characterized by massive amounts of very complex data and the need for complex data analysis software. Object-oriented database (OODB) systems have the potential of improving the description of the structure and semantics of this data and of integrating the analysis software with the data. This dissertation results from research to enhance OODB functionality and methodology to support scientific databases (SDBs) and, more specifically, to support a nuclear physics experiments database for the Continuous Electron Beam Accelerator Facility (CEBAF). This research to date has identified a number of problems related to the practical application of OODB technology to the conceptual design of the CEBAF experiments database and other SDBs: the lack of a generally accepted OODB design methodology, the lack of a standard OODB model, the lack of a clear conceptual level in existing OODB models, and the limited support in existing OODB systems for many common object relationships inherent in SDBs. To address these problems, the dissertation describes an Object-Relationship Diagram (ORD) and an Object-oriented Database Definition Language (ODDL) that provide tools that allow SDB design and development to proceed systematically and independently of existing OODB systems. These tools define multi-level, conceptual data models for SDB design, which incorporate a simple notation for describing common types of relationships that occur in SDBs. ODDL allows these relationships and other desirable SDB capabilities to be supported by an extended OODB system. A conceptual model of the CEBAF experiments database is presented in terms of ORDs and the ODDL to demonstrate their functionality and use and provide a foundation for future development of experimental nuclear physics software using an OODB approach.

Reparameterization of RNA chi Torsion Parameters for the AMBER Force Field and Comparison to NMR Spectra for Cytidine and Uridine.

PubMed

Yildirim, Ilyas; Stern, Harry A; Kennedy, Scott D; Tubbs, Jason D; Turner, Douglas H

2010-05-11

A reparameterization of the torsional parameters for the glycosidic dihedral angle, chi, for the AMBER99 force field in RNA nucleosides is used to provide a modified force field, AMBER99chi. Molecular dynamics simulations of cytidine, uridine, adenosine, and guanosine in aqueous solution using the AMBER99 and AMBER99chi force fields are compared with NMR results. For each nucleoside and force field, 10 individual molecular dynamics simulations of 30 ns each were run. For cytidine with AMBER99chi force field, each molecular dynamics simulation time was extended to 120 ns for convergence purposes. Nuclear magnetic resonance (NMR) spectroscopy, including one-dimensional (1D) (1)H, steady-state 1D (1)H nuclear Overhauser effect (NOE), and transient 1D (1)H NOE, was used to determine the sugar puckering and preferred base orientation with respect to the ribose of cytidine and uridine. The AMBER99 force field overestimates the population of syn conformations of the base orientation and of C2'-endo sugar puckering of the pyrimidines, while the AMBER99chi force field's predictions are more consistent with NMR results. Moreover, the AMBER99 force field prefers high anti conformations with glycosidic dihedral angles around 310 degrees for the base orientation of purines. The AMBER99chi force field prefers anti conformations around 185 degrees , which is more consistent with the quantum mechanical calculations and known 3D structures of folded ribonucleic acids (RNAs). Evidently, the AMBER99chi force field predicts the structural characteristics of ribonucleosides better than the AMBER99 force field and should improve structural and thermodynamic predictions of RNA structures.

Nuclear core and fuel assemblies

DOEpatents

Downs, Robert E.

1981-01-01

A fast flux nuclear core of a plurality of rodded, open-lattice assemblies having a rod pattern rotated relative to a rod support structure pattern. Elongated fuel rods are oriented on a triangular array and laterally supported by grid structures positioned along the length of the assembly. Initial inter-assembly contact is through strongbacks at the corners of the support pattern and peripheral fuel rods between adjacent assemblies are nested so as to maintain a triangular pitch across a clearance gap between the other portions of adjacent assemblies. The rod pattern is rotated relative to the strongback support pattern by an angle .alpha. equal to sin .sup.-1 (p/2c), where p is the intra-assembly rod pitch and c is the center-to-center spacing among adjacent assemblies.

NEUTRON-IRRADIATED STRUCTURES

DOEpatents

Ashley, E.L.; Ashley, J.W.; Bowker, H.W.; Hall, R.H.; Kendall, J.W.

1959-02-01

A moderator structure is described for a nuclear reactor of the heterogensous type wherein a large mass of moderator is provided with channels therethrough for the introduction of uranium serving as nuclear fuel and for the passage of a cooling fluid. The structure is comprised of blocks of moderator material in superposed horizontal layers, the blocks of each layer being tied together with spaces between them and oriented to have horizontal Wigner growth. The ties are strips of moderator material, the same as the blocks, with transverse Wigner growth, disposed horizontally along lines crossing at vertical axes of the blocks. The blocks are preferably rectangular with a larger or length dimension transverse to the directions of Wiguer growth and are stood on end to provide for horizontal growth.

Computational Nuclear Physics and Post Hartree-Fock Methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lietz, Justin; Sam, Novario; Hjorth-Jensen, M.

We present a computational approach to infinite nuclear matter employing Hartree-Fock theory, many-body perturbation theory and coupled cluster theory. These lectures are closely linked with those of chapters 9, 10 and 11 and serve as input for the correlation functions employed in Monte Carlo calculations in chapter 9, the in-medium similarity renormalization group theory of dense fermionic systems of chapter 10 and the Green's function approach in chapter 11. We provide extensive code examples and benchmark calculations, allowing thereby an eventual reader to start writing her/his own codes. We start with an object-oriented serial code and end with discussions onmore » strategies for porting the code to present and planned high-performance computing facilities.« less

Nuclear reactor internals alignment configuration

DOEpatents

Gilmore, Charles B [Greensburg, PA; Singleton, Norman R [Murrysville, PA

2009-11-10

An alignment system that employs jacking block assemblies and alignment posts around the periphery of the top plate of a nuclear reactor lower internals core shroud to align an upper core plate with the lower internals and the core shroud with the core barrel. The distal ends of the alignment posts are chamfered and are closely received within notches machined in the upper core plate at spaced locations around the outer circumference of the upper core plate. The jacking block assemblies are used to center the core shroud in the core barrel and the alignment posts assure the proper orientation of the upper core plate. The alignment posts may alternately be formed in the upper core plate and the notches may be formed in top plate.

Determination of the Order of Passes of AN Austenitic Weld by Optimization of AN Inversion Process of Ultrasound Data

NASA Astrophysics Data System (ADS)

Gueudré, C.; Marrec, L. Le; Chekroun, M.; Moysan, J.; Chassignole, B.; Corneloup, G.

2011-06-01

Multipass welds made in austenitic stainless steel, in the primary circuit of nuclear power plants with pressurized water reactors, are characterized by an anisotropic and heterogeneous structure that disturbs the ultrasonic propagation and challenge the ultrasonic non-destructive testing. The simulation in this type of structure is now possible thanks to the MINA code which allows the grain orientation modeling taking into account the welding process, and the ATHENA code to exactly simulate the ultrasonic propagation. We propose studying the case where the order of the passes is unknown to estimate the possibility of reconstructing this important parameter by ultrasound measures. The first results are presented.

New irradiation facilities for development of production methods of medical radionuclides at cyclotrons at Forschungszentrum Jülich

NASA Astrophysics Data System (ADS)

Spellerberg, S.; Scholten, B.; Spahn, I.; Felden, O.; Gebel, R.; Qaim, S. M.; Bai, M.; Neumaier, B.

2017-05-01

An essential basis for research and development work on radiopharmaceuticals is the efficient production of radionuclides of high quality. In this process research-oriented studies aiming for elucidation of biochemical processes require novel products. The radionuclide development at INM-5 entails basic research, e.g. the determination of nuclear reaction data, as well as technical aspects of practical production, such as high-current targetry, chemical separation, formulation and quality control. In this work developments, adaptation and optimization of irradiation facilities at the BC 1710, JULIC as Injector of COSY and COSY itself are summarized, which shall allow the extension of radionuclide production possibilities, aiming at innovations in medical applications.

Structure-Property Relationships in Surface-Modified Ceramics. NATO advanced Science Institutes, Series E: Applied Sciences, Volume 170

DTIC Science & Technology

1989-01-01

channelling and scanning electron microscopy (SEM) of highly oriented pyrolytic graphite ( HOPG ), comparative scratch testing results and some ideas on...electrode graphite , HOPG and carbon fibers also show enhanced wear resistance followoing irradiation (6), the extent of which depends upon the initial...literature dealing with damage effects and physical property changes following neutron irradiation of graphite (single and polycrystalline ) in nuclear

Nanometer-Scale Force Detected Nuclear Magnetic Resonance Imaging

DTIC Science & Technology

2013-01-01

different crystallographic orientation. Single crystal thin films should thus minimize the stray electric fields by reducing the number of grain ...from epitaxial Ag films, rather than polycrystalline Ag films. It is thought that grain boundaries in polycrystalline metal films give rise to stray...electric fields near the surface of the film. The electric fields are produced as a consequence of the work func- tion difference between grains of

Chromophore orientation in bacteriorhodopsin determined from the angular dependence of deuterium nuclear magnetic resonance spectra of oriented purple membranes.

PubMed

Moltke, S; Nevzorov, A A; Sakai, N; Wallat, I; Job, C; Nakanishi, K; Heyn, M P; Brown, M F

1998-08-25

The orientation of prosthetic groups in membrane proteins is of considerable importance in understanding their functional role in energy conversion, signal transduction, and ion transport. In this work, the orientation of the retinylidene chromophore of bacteriorhodopsin (bR) was investigated using 2H NMR spectroscopy. Bacteriorhodopsin was regenerated with all-trans-retinal stereospecifically deuterated in one of the geminal methyl groups on C1 of the cyclohexene ring. A highly oriented sample, which is needed to obtain individual bond orientations from 2H NMR, was prepared by forming hydrated lamellar films of purple membranes on glass slides. A Monte Carlo method was developed to accurately simulate the 2H NMR line shape due to the distribution of bond angles and the orientational disorder of the membranes. The number of free parameters in the line shape simulation was reduced by independent measurements of the intrinsic line width (1.6 kHz from T2e experiments) and the effective quadrupolar coupling constant (38. 8-39.8 kHz from analysis of the line shape of a powder-type sample). The angle between the C1-(1R)-1-CD3 bond and the purple membrane normal was determined with high accuracy from the simultaneous analysis of a series of 2H NMR spectra recorded at different inclinations of the uniaxially oriented sample in the magnetic field at 20 and -50 degrees C. The value of 68.7 +/- 2.0 degrees in dark-adapted bR was used, together with the previously determined angle of the C5-CD3 bond, to calculate the possible orientations of the cyclohexene ring in the membrane. The solutions obtained from 2H NMR were then combined with additional constraints from linear dichroism and electron cryomicroscopy to obtain the allowed orientations of retinal in the noncentrosymmetric membrane structure. The combined data indicate that the methyl groups on the polyene chain point toward the cytoplasmic side of the membrane and the N-H bond of the Schiff base to the extracellular side, i.e., toward the side of proton release in the pump pathway.

Development of Innovative Design Processor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Y.S.; Park, C.O.

2004-07-01

The nuclear design analysis requires time-consuming and erroneous model-input preparation, code run, output analysis and quality assurance process. To reduce human effort and improve design quality and productivity, Innovative Design Processor (IDP) is being developed. Two basic principles of IDP are the document-oriented design and the web-based design. The document-oriented design is that, if the designer writes a design document called active document and feeds it to a special program, the final document with complete analysis, table and plots is made automatically. The active documents can be written with ordinary HTML editors or created automatically on the web, which ismore » another framework of IDP. Using the proper mix-up of server side and client side programming under the LAMP (Linux/Apache/MySQL/PHP) environment, the design process on the web is modeled as a design wizard style so that even a novice designer makes the design document easily. This automation using the IDP is now being implemented for all the reload design of Korea Standard Nuclear Power Plant (KSNP) type PWRs. The introduction of this process will allow large reduction in all reload design efforts of KSNP and provide a platform for design and R and D tasks of KNFC. (authors)« less

Dynamic nuclear polarisation via the integrated solid effect II: experiments on naphthalene-h8 doped with pentacene-d14

NASA Astrophysics Data System (ADS)

Eichhorn, T. R.; van den Brandt, B.; Hautle, P.; Henstra, A.; Wenckebach, W. Th.

2014-07-01

In dynamic nuclear polarisation (DNP), also called hyperpolarisation, a small amount of unpaired electron spins is added to the sample containing the nuclear spins, and the polarisation of these unpaired electron spins is transferred to the nuclear spins by means of a microwave field. Traditional DNP polarises the electron spin of stable paramagnetic centres by cooling down to low temperature and applying a strong magnetic field. Then weak continuous wave microwave fields are used to induce the polarisation transfer. Complicated cryogenic equipment and strong magnets can be avoided using short-lived photo-excited triplet states that are strongly aligned in the optical excitation process. However, a much faster transfer of the electron spin polarisation is needed and pulsed DNP methods like nuclear orientation via electron spin locking (NOVEL) and the integrated solid effect (ISE) are used. To describe the polarisation transfer with the strong microwave fields in NOVEL and ISE, the usual perturbation methods cannot be used anymore. In the previous paper, we presented a theoretical approach to calculate the polarisation transfer in ISE. In the present paper, the theory is applied to the system naphthalene-h8 doped with pentacene-d14 yielding the photo-excited triplet states and compared with experimental results.

Observation of a new coherent transient in NMR -- nutational two-pulse stimulated echo in the angular distribution of γ-radiation from oriented nuclei

NASA Astrophysics Data System (ADS)

Shakhmuratova, L. N.; Hutchison, W. D.; Isbister, D. J.; Chaplin, D. H.

1997-07-01

A new coherent transient in pulsed NMR, the two-pulse nutational stimulated echo, is reported for the ferromagnetic system 60CoFe using resonant perturbations on the directional emission of anisotropic γ-radiation from thermally oriented nuclei. The new spin echo is a result of non-linear nuclear spin dynamics due to large Larmor inhomogeneity active during radiofrequency pulse application. It is made readily observable through the gross detuning between NMR radiofrequency excitation and gamma radiation detection, and inhomogeneity in the Rabi frequency caused by metallic skin-effect. The method of concatenation of perturbation factors in a statistical tensor formalism is quantitatively applied to successfully predict and then fit in detail the experimental time-domain data.

Portable nuclear material detector and process

DOEpatents

Hofstetter, Kenneth J [Aiken, SC; Fulghum, Charles K [Aiken, SC; Harpring, Lawrence J [North Augusta, SC; Huffman, Russell K [Augusta, GA; Varble, Donald L [Evans, GA

2008-04-01

A portable, hand held, multi-sensor radiation detector is disclosed. The detection apparatus has a plurality of spaced sensor locations which are contained within a flexible housing. The detection apparatus, when suspended from an elevation, will readily assume a substantially straight, vertical orientation and may be used to monitor radiation levels from shipping containers. The flexible detection array can also assume a variety of other orientations to facilitate any unique container shapes or to conform to various physical requirements with respect to deployment of the detection array. The output of each sensor within the array is processed by at least one CPU which provides information in a usable form to a user interface. The user interface is used to provide the power requirements and operating instructions to the operational components within the detection array.

GEM detector development for tokamak plasma radiation diagnostics: SXR poloidal tomography

NASA Astrophysics Data System (ADS)

Chernyshova, Maryna; Malinowski, Karol; Ziółkowski, Adam; Kowalska-Strzeciwilk, Ewa; Czarski, Tomasz; Poźniak, Krzysztof T.; Kasprowicz, Grzegorz; Zabołotny, Wojciech; Wojeński, Andrzej; Kolasiński, Piotr; Krawczyk, Rafał D.

2015-09-01

An increased attention to tungsten material is related to a fact that it became a main candidate for the plasma facing material in ITER and future fusion reactor. The proposed work refers to the studies of W influence on the plasma performances by developing new detectors based on Gas Electron Multiplier GEM) technology for tomographic studies of tungsten transport in ITER-oriented tokamaks, e.g. WEST project. It presents current stage of design and developing of cylindrically bent SXR GEM detector construction for horizontal port implementation. Concept to overcome an influence of constraints on vertical port has been also presented. It is expected that the detecting unit under development, when implemented, will add to the safe operation of tokamak bringing creation of sustainable nuclear fusion reactors a step closer.

Nucleus detection using gradient orientation information and linear least squares regression

NASA Astrophysics Data System (ADS)

Kwak, Jin Tae; Hewitt, Stephen M.; Xu, Sheng; Pinto, Peter A.; Wood, Bradford J.

2015-03-01

Computerized histopathology image analysis enables an objective, efficient, and quantitative assessment of digitized histopathology images. Such analysis often requires an accurate and efficient detection and segmentation of histological structures such as glands, cells and nuclei. The segmentation is used to characterize tissue specimens and to determine the disease status or outcomes. The segmentation of nuclei, in particular, is challenging due to the overlapping or clumped nuclei. Here, we propose a nuclei seed detection method for the individual and overlapping nuclei that utilizes the gradient orientation or direction information. The initial nuclei segmentation is provided by a multiview boosting approach. The angle of the gradient orientation is computed and traced for the nuclear boundaries. Taking the first derivative of the angle of the gradient orientation, high concavity points (junctions) are discovered. False junctions are found and removed by adopting a greedy search scheme with the goodness-of-fit statistic in a linear least squares sense. Then, the junctions determine boundary segments. Partial boundary segments belonging to the same nucleus are identified and combined by examining the overlapping area between them. Using the final set of the boundary segments, we generate the list of seeds in tissue images. The method achieved an overall precision of 0.89 and a recall of 0.88 in comparison to the manual segmentation.

Novel NMR tools to study structure and dynamics of biomembranes.

PubMed

Gawrisch, Klaus; Eldho, Nadukkudy V; Polozov, Ivan V

2002-06-01

Nuclear magnetic resonance (NMR) studies on biomembranes have benefited greatly from introduction of magic angle spinning (MAS) NMR techniques. Improvements in MAS probe technology, combined with the higher magnetic field strength of modern instruments, enables almost liquid-like resolution of lipid resonances. The cross-relaxation rates measured by nuclear Overhauser enhancement spectroscopy (NOESY) provide new insights into conformation and dynamics of lipids with atomic-scale resolution. The data reflect the tremendous motional disorder in the lipid matrix. Transfer of magnetization by spin diffusion along the proton network of lipids is of secondary relevance, even at a long NOESY mixing time of 300 ms. MAS experiments with re-coupling of anisotropic interactions, like the 13C-(1)H dipolar couplings, benefit from the excellent resolution of 13C shifts that enables assignment of the couplings to specific carbon atoms. The traditional 2H NMR experiments on deuterated lipids have higher sensitivity when conducted on oriented samples at higher magnetic field strength. A very large number of NMR parameters from lipid bilayers is now accessible, providing information about conformation and dynamics for every lipid segment. The NMR methods have the sensitivity and resolution to study lipid-protein interaction, lateral lipid organization, and the location of solvents and drugs in the lipid matrix.

Monte Carlo simulations in X-ray imaging

NASA Astrophysics Data System (ADS)

Giersch, Jürgen; Durst, Jürgen

2008-06-01

Monte Carlo simulations have become crucial tools in many fields of X-ray imaging. They help to understand the influence of physical effects such as absorption, scattering and fluorescence of photons in different detector materials on image quality parameters. They allow studying new imaging concepts like photon counting, energy weighting or material reconstruction. Additionally, they can be applied to the fields of nuclear medicine to define virtual setups studying new geometries or image reconstruction algorithms. Furthermore, an implementation of the propagation physics of electrons and photons allows studying the behavior of (novel) X-ray generation concepts. This versatility of Monte Carlo simulations is illustrated with some examples done by the Monte Carlo simulation ROSI. An overview of the structure of ROSI is given as an example of a modern, well-proven, object-oriented, parallel computing Monte Carlo simulation for X-ray imaging.

Resonant Electromagnetic Interaction in Low Energy Nuclear Reactions

NASA Astrophysics Data System (ADS)

Chubb, Scott

2008-03-01

Basic ideas about how resonant electromagnetic interaction (EMI) can take place in finite solids are reviewed. These ideas not only provide a basis for conventional, electron energy band theory (which explains charge and heat transport in solids), but they also explain how through finite size effects, it is possible to create many of the kinds of effects envisioned by Giuliano Preparata. The underlying formalism predicts that the orientation of the external fields in the SPAWAR protocolootnotetextKrivit, Steven B., New Energy Times, 2007, issue 21, item 10. http://newenergytimes.com/news/2007/NET21.htm^,ootnotetextSzpak, S.; Mosier-Boss, P.A.; Gordon, F.E. Further evidence of nuclear reactions in the Pd lattice: emission of charged particles. Naturwissenschaften 94,511(2007)..has direct bearing on the emission of high-energy particles. Resonant EMI also implies that nano-scale solids, of a particular size, provide an optimal environment for initiating Low Energy Nuclear Reactions (LENR) in the PdD system.

Advanced fuels campaign 2013 accomplishments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Braase, Lori; Hamelin, Doug

The mission of the Advanced Fuels Campaign (AFC) is to perform Research, Development, and Demonstration (RD&D) activities for advanced fuel forms (including cladding) to enhance the performance and safety of the nation’s current and future reactors; enhance proliferation resistance of nuclear fuel; effectively utilize nuclear energy resources; and address the longer-term waste management challenges. This includes development of a state-of-the art Research and Development (R&D) infrastructure to support the use of “goal-oriented science-based approach.” In support of the Fuel Cycle Research and Development (FCRD) program, AFC is responsible for developing advanced fuels technologies to support the various fuel cycle optionsmore » defined in the Department of Energy (DOE) Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. Accomplishments made during fiscal year (FY) 2013 are highlighted in this report, which focuses on completed work and results. The process details leading up to the results are not included; however, the technical contact is provided for each section.« less

Nuclear fuel pellet sintering boat unloading apparatus and method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huggins, T.B.; Widener, W.H.; Klapper, K.K.

1990-05-22

This patent describes a method for unloading nuclear fuel pellets from a sintering boat having an open top. It comprises: pivoting a transfer housing loaded with the boat filled with nuclear fuel pellets about a generally horizontal axis from an upright position remote from a pellet deposit surface to an inverted position adjacent to the deposit surface to move the boat from an upright to inverted orientation with the pellets retained within the boat by a latched lid in a closed condition on the housing; unlatching the lid of the housing as the housing reaches its inverted position but engagingmore » the unlatched lid with the deposit surface to retain it in its closed condition; and reverse pivoting the housing from its inverted position back toward its upright position to permit the unlatched lid to pivot from the closed condition to an opened condition thereby allowing pellets to slide out of the open top of the inverted boat and down the opened lid of the housing to the deposit site.« less

Three-Dimensional Orientation of Anisotropic Plasmonic Aggregates at Intracellular Nuclear Indentation Sites by Integrated Light Sheet Super-Resolution Microscopy.

PubMed

Chakkarapani, Suresh Kumar; Sun, Yucheng; Lee, Seungah; Fang, Ning; Kang, Seong Ho

2018-05-22

Three-dimensional (3D) orientations of individual anisotropic plasmonic nanoparticles in aggregates were observed in real time by integrated light sheet super-resolution microscopy ( iLSRM). Asymmetric light scattering of a gold nanorod (AuNR) was used to trigger signals based on the polarizer angle. Controlled photoswitching was achieved by turning the polarizer and obtaining a series of images at different polarization directions. 3D subdiffraction-limited super-resolution images were obtained by superlocalization of scattering signals as a function of the anisotropic optical properties of AuNRs. Varying the polarizer angle allowed resolution of the orientation of individual AuNRs. 3D images of individual nanoparticles were resolved in aggregated regions, resulting in as low as 64 nm axial resolution and 28 nm spatial resolution. The proposed imaging setup and localization approach demonstrates a convenient method for imaging under a noisy environment where the majority of scattering noise comes from cellular components. This integrated 3D iLSRM and localization technique was shown to be reliable and useful in the field of 3D nonfluorescence super-resolution imaging.

Numerical Modeling of S-Wave Generation by Fracture Damage in Underground Nuclear Explosions

DTIC Science & Technology

2009-09-30

Element Package, ABAQUS. A user -defined subroutine , VUMAT, was written that incorporates the micro-mechanics based damage constitutive law described...dynamic damage evolution on the elastic and anelastic response. 2) whereas the Ashby/Sammis model was only applicable to the case where the initial cracks ...are all parallel and the same size, we can now include a specified distribution of initial crack sizes with random azimuthal orientation about the

The Multilateralization of Regional Security in Southeast and Northeast Asia: The Role of the Soviet Union

DTIC Science & Technology

1991-04-01

strategic, much less economic, mixed and conflicting strategies pursued by the advantages. Moreover, the socioeconomic gap principal regional and...By the early of Africa (Ethiopia) in favor of Moscow-backed 1980s, the market -oriented states of the West and forces. Japan, associated in the...incorporation of these economies into the capitalist nuclear war. Since each held the other hostage, only global market system. The gross inefficiencies

FERRET data analysis code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmittroth, F.

1979-09-01

A documentation of the FERRET data analysis code is given. The code provides a way to combine related measurements and calculations in a consistent evaluation. Basically a very general least-squares code, it is oriented towards problems frequently encountered in nuclear data and reactor physics. A strong emphasis is on the proper treatment of uncertainties and correlations and in providing quantitative uncertainty estimates. Documentation includes a review of the method, structure of the code, input formats, and examples.

Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F.

PubMed

Loftus, Kyle M; Cui, Heying; Coutavas, Elias; King, David S; Ceravolo, Amanda; Pereiras, Dylan; Solmaz, Sozanne R

2017-08-03

Centromere protein F (CENP-F) is a component of the kinetochore and a regulator of cell cycle progression. CENP-F recruits the dynein transport machinery and orchestrates several cell cycle-specific transport events, including transport of the nucleus, mitochondria and chromosomes. A key regulatory step for several of these functions is likely the G2 phase-specific export of CENP-F from the nucleus to the cytosol, where the cytoplasmic dynein transport machinery resides; however, the molecular mechanism of this process is elusive. Here, we have identified 3 phosphorylation sites within the bipartite classical nuclear localization signal (cNLS) of CENP-F. These sites are specific for cyclin-dependent kinase 1 (Cdk1), which is active in G2 phase. Phosphomimetic mutations of these residues strongly diminish the interaction of the CENP-F cNLS with its nuclear transport receptor karyopherin α. These mutations also diminish nuclear localization of the CENP-F cNLS in cells. Notably, the cNLS is phosphorylated in the -1 position, which is important to orient the adjacent major motif for binding into its pocket on karyopherin α. We propose that localization of CENP-F is regulated by a cNLS, and a nuclear export pathway, resulting in nuclear localization during most of interphase. In G2 phase, the cNLS is weakened by phosphorylation through Cdk1, likely resulting in nuclear export of CENP-F via the still active nuclear export pathway. Once CENP-F resides in the cytosol, it can engage in pathways that are important for cell cycle progression, kinetochore assembly and the faithful segregation of chromosomes into daughter cells.

In-Beam Studies of High-Spin States in Mercury -184 and MERCURY-193 and Polarization Studies

NASA Astrophysics Data System (ADS)

Deng, Jingkang

The high-spin states in ^{184 }Hg and ^{193}Hg were studied by using the reactions ^{156 }Gd(^{32}S, 4n)^{184}Hg, in the spin spectrometer and ^{150}Nd( ^{48}Ca, 5n)^ {193}Hg, in the gamma -ray spectrometer, respectively, with the beams provided by the 25 MV tandem accelerator at the Holifield Heavy Ion Research Facility. Seven new rotational bands were observed for the first time in ^{184}Hg based on gamma-gamma coincidences with the use of a multiplicity filter. Spin assignments were based on the measured directional correlations for oriented nuclei (DCO ratios). The well-deformed prolate band was tentatively extended to 26^+ state. One new band in ^{184} Hg has a moment of inertia very similar to that of the s-band in ^{186}Hg which is assigned a (651, 1/2) otimes (770, 1/2) neutron configuration. However, it starts with a spin state of 5hbar, while the s-band in the ^{186}Hg starts with a I^pi = 11 ^- state. Some other bands were found in ^{184}Hg which are similar to ones in ^{186}Hg. However a pair of signature partner bands without signature splitting not seen in ^{186}Hg is observed. It shows the same alignment pattern below the band crossing with the bands in ^{182 }Pt and ^{180}Os lying in the N = 104 chain which consist of a nu(i_{13/2}h_{9/2} ) or nu(i_{13/2}f _{7/2}) configuration. A decay sequence above the 47/2, 5.4 MeV level in ^{193}Hg was established through discrete gamma-ray spectroscopy. This sequence was shown to feed several previously known levels in ^{193}Hg. The new energy levels exhibit non-collective single-particle character implying the dominant role of particle alignment mode at the moderate spin. This is in contrast to the collective bands observed in nearby lead isotope. The polarization detection efficiency of a symmetrical four Ge detector Compton polarimeter with the four detectors housed in one cryostat was measured by using the UNISOR low temperature nuclear orientation facility at HHIRF. It was shown that this Compton polarimeter has superior polarization detection efficiency compared to three detector and multisegment detector designs. It is suitable for polarization measurements in both low temperature and in-beam nuclear orientation studies. This detector was used during an in-beam spectroscopic study of ^{186}Hg and provided the crucial data which yielded a change in parity for the new band with deformation intermediate between normal and superdeformation in ^{186 }Hg.

The nuclear high excitation outflow cone in NGC 1365

NASA Astrophysics Data System (ADS)

Per Lindblad, Olof; Hjelm, Maja; Jörsäter, Steven; Kristen, Helmuth

The morphology and kinematics of the high excitation outflow cone in the nuclear region of the Seyfert 1.5 galaxy NGC 1365 is investigated. An empirical model based on ground-based [OIII] emission line data consists of a somewhat hollow double cone with its apex at the Seyfert nucleus. The cone axis is well aligned in space with the normal to the symmetry plane of the galaxy and the position angle of its projection on the sky coincides closely with that of a jet-like radio feature. The opening angle of the cone is 100° and the orientation such that the line of sight to the Seyfert 1.5 nucleus falls inside the cone. The outflow velocities within the cone are accelerated and fall off towards the edge.

Dynamical approach to heavy-ion induced fusion using actinide target

NASA Astrophysics Data System (ADS)

Aritomo, Y.; Hagino, K.; Chiba, S.; Nishio, K.

2012-10-01

To treat heavy-ion reactions using actinide target nucleus, we propose a model which takes into account the coupling to the collective states of interacting nuclei in the penetration of the Coulomb barrier and the dynamical evolution of nuclear shape from the contact configuration. A fluctuation-dissipation model (Langevin equation) was applied in the dynamical calculation, where effect of nuclear orientation at the initial impact on the prolately deformed target nucleus was considered. Using this model, we analyzed the experimental data for the mass distribution of fission fragments (MDFF) in the reaction of 36S+238U at several incident energies. Fusion-fission, quasifission and deep-quasi-fission are separated as different trajectories on the potential energy surface. We estimated the fusion cross section of the reaction.

Getting ready for petaflop capacities and beyond: a utility perspective

NASA Astrophysics Data System (ADS)

Hamelin, J. F.; Berthou, J. Y.

2008-07-01

Why should EDF, the leading producer and marketer of electricity in Europe, start adding teraflops to its terawatt-hours and become involved in high-performance computing (HPC)? In this paper we answer this question through examples of major opportunities that HPC brings to our business today and, we hope well into the future of petaflop and exaflop computing. Five cases are presented dealing with nondestructive testing, nuclear fuel management, mechanical behavior of nuclear fuel assemblies, water management, and energy management. For each case we show the benefits brought by HPC, describe the current level of numerical simulation performance, and discuss the perspectives for future steps. We also present the general background that explains why EDF is moving to this technology and briefly comment on the development of user-oriented simulation platforms.

The Development of Study Orientations and Study Success in Students of Pharmacy

ERIC Educational Resources Information Center

Nieminen, Juha; Lindblom-Ylanne, Sari; Lonka, Kirsti

2004-01-01

In research literature, two study orientations have been identified: meaning orientation and reproducing orientation. Few studies have examined how study orientations and conceptions of knowledge (epistemologies) interrelate. Further, longitudinal studies of the development of orientations and of conceptions of knowledge in relation to academic…

Effect of Velocity of Detonation of Explosives on Seismic Radiation

NASA Astrophysics Data System (ADS)

Stroujkova, A. F.; Leidig, M.; Bonner, J. L.

2014-12-01

We studied seismic body wave generation from four fully contained explosions of approximately the same yields (68 kg of TNT equivalent) conducted in anisotropic granite in Barre, VT. The explosions were detonated using three types of explosives with different velocities of detonation (VOD): Black Powder (BP), Ammonium Nitrate Fuel Oil/Emulsion (ANFO), and Composition B (COMP B). The main objective of the experiment was to study differences in seismic wave generation among different types of explosives, and to determine the mechanism responsible for these differences. The explosives with slow burn rate (BP) produced lower P-wave amplitude and lower corner frequency, which resulted in lower seismic efficiency (0.35%) in comparison with high burn rate explosives (2.2% for ANFO and 3% for COMP B). The seismic efficiency estimates for ANFO and COMP B agree with previous studies for nuclear explosions in granite. The body wave radiation pattern is consistent with an isotropic explosion with an added azimuthal component caused by vertical tensile fractures oriented along pre-existing micro-fracturing in the granite, although the complexities in the P- and S-wave radiation patterns suggest that more than one fracture orientation could be responsible for their generation. High S/P amplitude ratios and low P-wave amplitudes suggest that a significant fraction of the BP source mechanism can be explained by opening of the tensile fractures as a result of the slow energy release.

MOOSE: A PARALLEL COMPUTATIONAL FRAMEWORK FOR COUPLED SYSTEMS OF NONLINEAR EQUATIONS.

DOE Office of Scientific and Technical Information (OSTI.GOV)

G. Hansen; C. Newman; D. Gaston

Systems of coupled, nonlinear partial di?erential equations often arise in sim- ulation of nuclear processes. MOOSE: Multiphysics Ob ject Oriented Simulation Environment, a parallel computational framework targeted at solving these systems is presented. As opposed to traditional data / ?ow oriented com- putational frameworks, MOOSE is instead founded on mathematics based on Jacobian-free Newton Krylov (JFNK). Utilizing the mathematical structure present in JFNK, physics are modularized into “Kernels” allowing for rapid production of new simulation tools. In addition, systems are solved fully cou- pled and fully implicit employing physics based preconditioning allowing for a large amount of ?exibility even withmore » large variance in time scales. Background on the mathematics, an inspection of the structure of MOOSE and several rep- resentative solutions from applications built on the framework are presented.« less

The angular dependence of pulse shape discrimination and detection sensitivity in cylindrical and cubic EJ-309 organic liquid scintillators

NASA Astrophysics Data System (ADS)

Jones, A. R.; Joyce, M. J.

2017-01-01

Liquid scintillators are used widely for neutron detection and for the assay of nuclear materials. However, due to the constituents of the detector and the nitrogen void within the detector cell, usually incorporated to accommodate any expansion that might occur to avoid leakage, fluctuations in detector response have been observed associated with the orientation of the detector when in use. In this work the angular dependence of the pulse-shape discrimination performance in an EJ309 liquid scintillator has been investigated with 252Cf in terms of the separation of γ -ray and neutron events, described quantitatively by the figure-of-merit. A subtle dependence in terms of pulse-shape discrimination is observed. In contrast, a more significant dependence of detection sensitivity with the angle of orientation is evident.

MOOSE: A parallel computational framework for coupled systems of nonlinear equations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Derek Gaston; Chris Newman; Glen Hansen

Systems of coupled, nonlinear partial differential equations (PDEs) often arise in simulation of nuclear processes. MOOSE: Multiphysics Object Oriented Simulation Environment, a parallel computational framework targeted at the solution of such systems, is presented. As opposed to traditional data-flow oriented computational frameworks, MOOSE is instead founded on the mathematical principle of Jacobian-free Newton-Krylov (JFNK) solution methods. Utilizing the mathematical structure present in JFNK, physics expressions are modularized into `Kernels,'' allowing for rapid production of new simulation tools. In addition, systems are solved implicitly and fully coupled, employing physics based preconditioning, which provides great flexibility even with large variance in timemore » scales. A summary of the mathematics, an overview of the structure of MOOSE, and several representative solutions from applications built on the framework are presented.« less

Open-Access, Low-Magnetic-Field MRI System for Lung Research

NASA Technical Reports Server (NTRS)

Mair, Ross W.; Rosen, Matthew S.; Tsai, Leo L.; Walsworth, Ronald L.; Hrovat, Mirko I.; Patz, Samuel; Ruset, Iullian C.; Hersman, F. William

2009-01-01

An open-access magnetic resonance imaging (MRI) system is being developed for use in research on orientational/gravitational effects on lung physiology and function. The open-access geometry enables study of human subjects in diverse orientations. This system operates at a magnetic flux density, considerably smaller than the flux densities of typical other MRI systems, that can be generated by resistive electromagnet coils (instead of the more-expensive superconducting coils of the other systems). The human subject inhales air containing He-3 or Xe-129 atoms, the nuclear spins of which have been polarized by use of a laser beam to obtain a magnetic resonance that enables high-resolution gas space imaging at the low applied magnetic field. The system includes a bi-planar, constant-current, four-coil electromagnet assembly and associated electronic circuitry to apply a static magnetic field of 6.5 mT throughout the lung volume; planar coils and associated circuitry to apply a pulsed magnetic-field-gradient for each spatial dimension; a single, detachable radio-frequency coil and associated circuitry for inducing and detecting MRI signals; a table for supporting a horizontal subject; and electromagnetic shielding surrounding the electromagnet coils.

Factors to consider for trace element deposition biomonitoring surveys with lichen transplants

USGS Publications Warehouse

Ayrault, S.; Clochiatti, R.; Carrot, F.; Daudin, L.; Bennett, J.P.

2007-01-01

A trace element deposition biomonitoring experiment with transplants of the fruticose lichen Evernia prunastri was developed, aimed at monitoring the effects of different exposure parameters (exposure orientation and direct rain) and to the elements Ti, V, Cr, Co, Cu, Zn, Rb, Cd, Sb and Pb. Accumulations were observed for most of the elements, confirming the ability of Evernia transplants for atmospheric metal deposition monitoring. The accumulation trends were mainly affected by the exposure orientation and slightly less so by the protection from rain. The zonation of the trace elements inside the thallus was also studied. It was concluded that trace element concentrations were not homogeneous in Evernia, thus imposing some cautions on the sampling approach. A nuclear microprobe analysis of an E. prunastri transplanted thallus in thin cross-sections concluded that the trace elements were mainly concentrated on the cortex of the thallus, except Zn, Ca and K which were also present in the internal layers. The size of the particles deposited or entrapped on the cortex surface averaged 7????m. A list of key parameters to ensure the comparability of surveys aiming at observing temporal or spatial deposition variation is presented. ?? 2006 Elsevier B.V. All rights reserved.

Magnetic moment of the fragmentation-aligned 61Fe (9/2(+)) isomer.

PubMed

Matea, I; Georgiev, G; Daugas, J M; Hass, M; Neyens, G; Astabatyan, R; Baby, L T; Balabanski, D L; Bélier, G; Borremans, D; Goldring, G; Goutte, H; Himpe, P; Lewitowicz, M; Lukyanov, S; Méot, V; Santos, F de Oliveira; Penionzhkevich, Yu E; Roig, O; Sawicka, M

2004-10-01

We report on the g factor measurement of an isomer in the neutron-rich (61)(26)Fe (E(*)=861 keV and T(1/2)=239(5) ns). The isomer was produced and spin aligned via a projectile-fragmentation reaction at intermediate energy, the time dependent perturbed angular distribution method being used for the measurement of the g factor. For the first time, due to significant improvements of the experimental technique, an appreciable residual alignment of the nuclear spin ensemble has been observed, allowing a precise determination of its g factor, including the sign: g=-0.229(2). In this way we open the possibility to study moments of very neutron-rich short-lived isomers, not accessible via other production and spin-orientation methods.

A SMALL-ANGLE DRILL-HOLE WHIPSTOCK

DOEpatents

Nielsen, D.E.; Olsen, J.L.; Bennett, W.P.

1963-01-29

A small angle whipstock is described for accurately correcting or deviating a drill hole by a very small angle. The whipstock is primarily utilized when drilling extremely accurate, line-of-slight test holes as required for diagnostic studies related to underground nuclear test shots. The invention is constructed of a length of cylindrical pipe or casing, with a whipstock seating spike extending from the lower end. A wedge-shaped segment is secured to the outer circumference of the upper end of the cylinder at a position diametrically opposite the circumferential position of the spike. Pin means are provided for affixing the whipstock to a directional drill bit and stem to alloy orienting and setting the whipstock properly in the drill hole. (AEC)

Research on Modeling Technology of Virtual Robot Based on LabVIEW

NASA Astrophysics Data System (ADS)

Wang, Z.; Huo, J. L.; Y Sun, L.; Y Hao, X.

2017-12-01

Because of the dangerous working environment, the underwater operation robot for nuclear power station needs manual teleoperation. In the process of operation, it is necessary to guide the position and orientation of the robot in real time. In this paper, the geometric modeling of the virtual robot and the working environment is accomplished by using SolidWorks software, and the accurate modeling and assembly of the robot are realized. Using LabVIEW software to read the model, and established the manipulator forward kinematics and inverse kinematics model, and realized the hierarchical modeling of virtual robot and computer graphics modeling. Experimental results show that the method studied in this paper can be successfully applied to robot control system.

Temporal and spatial coordination of chromosome movement, spindle formation, and nuclear envelope breakdown during prometaphase in Drosophila melanogaster embryos.

PubMed

Hiraoka, Y; Agard, D A; Sedat, J W

1990-12-01

The spatial and temporal dynamics of diploid chromosome organization, microtubule arrangement, and the state of the nuclear envelope have been analyzed in syncytial blastoderm embryos of Drosophila melanogaster during the transition from prophase to metaphase, by three-dimensional optical sectioning microscopy. Time-lapse, three-dimensional data recorded in living embryos revealed that congression of chromosomes (the process whereby chromosomes move to form the metaphase plate) at prometaphase occurs as a wave, starting at the top of the nucleus near the embryo surface and proceeding through the nucleus to the bottom. The time-lapse analysis was augmented by a high-resolution analysis of fixed embryos where it was possible to unambiguously trace the three-dimensional paths of individual chromosomes. In prophase, the centromeres were found to be clustered at the top of the nucleus while the telomeres were situated at the bottom of the nucleus or towards the embryo interior. This polarized centromere-telomere orientation, perpendicular to the embryo surface, was preserved during the process of prometaphase chromosome congression. Correspondingly, breakdown of the nuclear envelope started at the top of the nucleus with the mitotic spindle being formed at the positions of the partial breakdown of the nuclear envelope. Our observation provide an example in which nuclear structures are spatially organized and their functions are locally and coordinately controlled in three dimensions.

Influence of oxide microstructure on corrosion behavior of zirconium-based model alloys

NASA Astrophysics Data System (ADS)

Silva, Marcelo Jose Gomes Da

The extensive utilization of zirconium-based alloys in fuel cladding and other reactor internal components in the nuclear power industry has led to the continuous improvement of these alloys. At the present moment, demands for better performing nuclear fuel cladding materials are increasing. Also, new reactor designs have been proposed that would require the materials to withstand even more rigorous conditions. One of the factors that limit s fuel cladding utilization in nuclear reactors is uniform corrosion and the consequent hydriding of the fuel. In an attempt to develop mechanistic understanding of the role of alloying elements in the growth of a stable protective oxide, a series of model zirconium-based alloys was prepared (Zr-xFe-yCr, Zr-xCu-yMo, Zr-xNb-ySn, for various x and y, pure Zr and Zircaloy-4) and examined with advanced characterization techniques. The alloys were corrosion tested in autoclaves under three different conditions: 360°C water, 500°C steam and 500°C supercritical water in excess of 400 days. These autoclave testing conditions simulate nuclear reactor environment for both current designs (360°C water) and the new supercritical water reactor (500°C steam and 500°C supercritical water) proposed by the generation-IV initiative. The oxide films formed were systematically examined at the Advanced Photon Source using microbeam synchrotron radiation diffraction and fluorescence of cross-sectional samples to determine the oxide phases present and their crystallographic texture as a function of distance from the metal/oxide interface. Also, the overall texture of the oxide layers was investigated using synchrotron radiation diffraction in frontal geometry. The corrosion kinetics is a function of the alloy system and showed a wide range of behaviors, from immediately unstable oxide growth to stable behavior. The corrosion weight gains from testing at high temperature are a factor of five higher than those measured at 360°C but the protectiveness ranking of the alloys is similar. Measured pole figures from different oxides in different corrosion regimes showed that monoclinic oxides grow in slightly distinct directions: protective oxides grow along the (-904)m pole, whether non-protective oxides grow along or close to the (-302)m pole. The angle in between these two directions ((-904)m and (-302)m) is about 6°. Microbeam synchrotron radiation diffraction and fluorescence was performed in the oxide layers and systematic differences are observed in protective and non-protective oxides, both near the oxide/metal interface and in the bulk of the oxide layers. The non-protective oxide interfaces show a smooth transition from metal to oxide with metal diffraction peaks disappearing as the monoclinic oxide peaks appear. In contrast, in a protective oxide, a complex structure near the oxide/metal interface was seen, showing peaks from Zr 3O suboxide and a highly oriented tetragonal oxide phase with specific orientation relationships with the monoclinic oxide and the base metal. The highly oriented tetragonal phase, only present in protective oxides, is believed to be a precursor to the formation of monoclinic oxide found in the bulk of the oxide layer. This plane may promote stable growth by causing the oxide to form in a manner that maximizes occupation of the substrate surface and minimizes stress accumulation, leading to more stable oxide growth. The association seen in this work of the precursor oxide phase with protective oxides and its orientation relationship with the monoclinic oxide, combined with the difference in oxide growth direction seen between protective and non-protective oxides, is interpreted as evidence that this phase allows a more properly oriented oxide to grow, in a way that minimizes stress accumulation and therefore delays the oxide transition to larger oxide thicknesses.

Web Application Design Using Server-Side JavaScript

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hampton, J.; Simons, R.

1999-02-01

This document describes the application design philosophy for the Comprehensive Nuclear Test Ban Treaty Research & Development Web Site. This design incorporates object-oriented techniques to produce a flexible and maintainable system of applications that support the web site. These techniques will be discussed at length along with the issues they address. The overall structure of the applications and their relationships with one another will also be described. The current problems and future design changes will be discussed as well.

Input data requirements for special processors in the computation system containing the VENTURE neutronics code. [LMFBR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vondy, D.R.; Fowler, T.B.; Cunningham, G.W.

1979-07-01

User input data requirements are presented for certain special processors in a nuclear reactor computation system. These processors generally read data in formatted form and generate binary interface data files. Some data processing is done to convert from the user oriented form to the interface file forms. The VENTURE diffusion theory neutronics code and other computation modules in this system use the interface data files which are generated.

A fifth major genetic group among honeybees revealed in Syria.

PubMed

Alburaki, Mohamed; Bertrand, Bénédicte; Legout, Hélène; Moulin, Sibyle; Alburaki, Ali; Sheppard, Walter Steven; Garnery, Lionel

2013-12-06

Apiculture has been practiced in North Africa and the Middle-East from antiquity. Several thousand years of selective breeding have left a mosaic of Apis mellifera subspecies in the Middle-East, many uniquely adapted and survived to local environmental conditions. In this study we explore the genetic diversity of A. mellifera from Syria (n = 1258), Lebanon (n = 169) and Iraq (n = 35) based on 14 short tandem repeat (STR) loci in the context of reference populations from throughout the Old World (n = 732). Our data suggest that the Syrian honeybee Apis mellifera syriaca occurs in both Syrian and Lebanese territories, with no significant genetic variability between respective populations from Syria and Lebanon. All studied populations clustered within a new fifth independent nuclear cluster, congruent with an mtDNA Z haplotype identified in a previous study. Syrian honeybee populations are not associated with Oriental lineage O, except for sporadic introgression into some populations close to the Turkish and Iraqi borders. Southern Syrian and Lebanese populations demonstrated high levels of genetic diversity compared to the northern populations. This study revealed the effects of foreign queen importations on Syrian bee populations, especially for the region of Tartus, where extensive introgression of A. m. anatolica and/or A. m. caucasica alleles were identified. The policy of creating genetic conservation centers for the Syrian subspecies should take into consideration the influence of the oriental lineage O from the northern Syrian border and the large population of genetically divergent indigenous honeybees located in southern Syria.

Resolving the Nuclear Obscuring Disk in the Compton-thick Seyfert Galaxy NGC 5643 with ALMA

NASA Astrophysics Data System (ADS)

Alonso-Herrero, A.; Pereira-Santaella, M.; García-Burillo, S.; Davies, R. I.; Combes, F.; Asmus, D.; Bunker, A.; Díaz-Santos, T.; Gandhi, P.; González-Martín, O.; Hernán-Caballero, A.; Hicks, E.; Hönig, S.; Labiano, A.; Levenson, N. A.; Packham, C.; Ramos Almeida, C.; Ricci, C.; Rigopoulou, D.; Rosario, D.; Sani, E.; Ward, M. J.

2018-06-01

We present ALMA Band 6 12CO(2–1) line and rest-frame 232 GHz continuum observations of the nearby Compton-thick Seyfert galaxy NGC 5643 with angular resolutions 0.″11–0.″26 (9–21 pc). The CO(2–1) integrated line map reveals emission from the nuclear and circumnuclear region with a two-arm nuclear spiral extending ∼10″ on each side. The circumnuclear CO(2–1) kinematics can be fitted with a rotating disk, although there are regions with large residual velocities and/or velocity dispersions. The CO(2–1) line profiles of these regions show two different velocity components. One is ascribed to the circular component and the other to the interaction of the AGN outflow, as traced by the [O III]λ5007 Å emission, with molecular gas in the disk a few hundred parsecs from the AGN. On nuclear scales, we detected an inclined CO(2–1) disk (diameter 26 pc, FWHM) oriented almost in a north–south direction. The CO(2–1) nuclear kinematics can be fitted with a rotating disk that appears to be tilted with respect to the large-scale disk. There are strong non-circular motions in the central 0.″2–0.″3 with velocities of up to 110 km s‑1. In the absence of a nuclear bar, these motions could be explained as radial outflows in the nuclear disk. We estimate a total molecular gas mass for the nuclear disk of M(H2) = 1.1 × 107 M ⊙ and an H2 column density toward the location of the AGN of N(H2) ∼ 5 × 1023 cm‑2, for a standard CO-to-H2 conversion factor. We interpret this nuclear molecular gas disk as the obscuring torus of NGC 5643 as well as the collimating structure of the ionization cone.

A multi wavelength study of the circumnuclear region of NGC 1365

NASA Astrophysics Data System (ADS)

Kristen, H.; Sandqvist, A. A.; Lindblad, P. O.

We select a sample of five barred spiral galaxies in order to test previous findings concerning NGC 1365. The H I halos of the investigated objects are found to be compact. The effect of companions on the H I extent is illustrated. The central region of NGC 1365 has been mapped in the J = 3-2 CO emission line with the 15-m SEST, which has a HPBW of 15" at the frequency of this transition. The observing grid has a 5"-spacing in the inner and a 10"-spacing in the outer region. A Maximum Entropy Method (MEM) deconvolution has been performed on the inner region observations. A circumnuclear molecular torus with a radius of about 5" is the dominant feature. Molecular emission is also seen coming from various dust streamers in the bar of the galaxy. The velocity field of the molecular region agrees well with predictions of models of gas streaming in the bar and nuclear region. Comparisons with 7"-resolution VLA observations of H I absorption in the nuclear region are discussed. The morphology and kinematics of the high excitation outflow cone in the nuclear region of the Seyfert 1.5 galaxy NGC 1365 is investigated. The opening angle of the cone is 100 degrees, and the orientation such that the line of sight to the Seyfert 1.5 nucleus falls inside the cone. The outflow velocities within the cone are accelerated and fall off towards the edge. An HST FOC exposure of the nuclear region in [OIII] emission shows the cone to contain a large number of discrete clouds. Seen in the B band, a number of star forming regions surround the nucleus, of which the brightest seem to have absolute magnitudes of about -16.6 magnitudes.

Investigations on optimization of accident management measures following a station blackout accident in a VVER-1000 pressurized water reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tusheva, P.; Schaefer, F.; Kliem, S.

2012-07-01

The reactor safety issues are of primary importance for preserving the health of the population and ensuring no release of radioactivity and fission products into the environment. A part of the nuclear research focuses on improvement of the safety of existing nuclear power plants. Studies, research and efforts are a continuing process at improving the safety and reliability of existing and newly developed nuclear power plants at prevention of a core melt accident. Station blackout (loss of AC power supply) is one of the dominant accidents taken into consideration at performing accident analysis. In case of multiple failures of safetymore » systems it leads to a severe accident. To prevent an accident to turn into a severe one or to mitigate the consequences, accident management measures must be performed. The present paper outlines possibilities for application and optimization of accident management measures following a station blackout accident. Assessed is the behaviour of the nuclear power plant during a station blackout accident without accident management measures and with application of primary/secondary side oriented accident management measures. Discussed are the possibilities for operators ' intervention and the influence of the performed accident management measures on the course of the accident. Special attention has been paid to the effectiveness of the passive feeding and physical phenomena having an influence on the system behaviour. The performed simulations show that the effectiveness of the secondary side feeding procedure can be limited due to an early evaporation or flashing effects in the feed water system. The analyzed cases show that the effectiveness of the accident management measures strongly depends on the initiation criteria applied for depressurization of the reactor coolant system. (authors)« less

Use of the Fracture Continuum Model for Numerical Modeling of Flow and Transport of Deep Geologic Disposal of Nuclear Waste in Crystalline Rock

NASA Astrophysics Data System (ADS)

Hadgu, T.; Kalinina, E.; Klise, K. A.; Wang, Y.

2015-12-01

Numerical modeling of disposal of nuclear waste in a deep geologic repository in fractured crystalline rock requires robust characterization of fractures. Various methods for fracture representation in granitic rocks exist. In this study we used the fracture continuum model (FCM) to characterize fractured rock for use in the simulation of flow and transport in the far field of a generic nuclear waste repository located at 500 m depth. The FCM approach is a stochastic method that maps the permeability of discrete fractures onto a regular grid. The method generates permeability fields using field observations of fracture sets. The original method described in McKenna and Reeves (2005) was designed for vertical fractures. The method has since then been extended to incorporate fully three-dimensional representations of anisotropic permeability, multiple independent fracture sets, and arbitrary fracture dips and orientations, and spatial correlation (Kalinina et al. 20012, 2014). For this study the numerical code PFLOTRAN (Lichtner et al., 2015) has been used to model flow and transport. PFLOTRAN solves a system of generally nonlinear partial differential equations describing multiphase, multicomponent and multiscale reactive flow and transport in porous materials. The code is designed to run on massively parallel computing architectures as well as workstations and laptops (e.g. Hammond et al., 2011). Benchmark tests were conducted to simulate flow and transport in a specified model domain. Distributions of fracture parameters were used to generate a selected number of realizations. For each realization, the FCM method was used to generate a permeability field of the fractured rock. The PFLOTRAN code was then used to simulate flow and transport in the domain. Simulation results and analysis are presented. The results indicate that the FCM approach is a viable method to model fractured crystalline rocks. The FCM is a computationally efficient way to generate realistic representation of complex fracture systems. This approach is of interest for nuclear waste disposal models applied over large domains.

Thermal barrier and support for nuclear reactor fuel core

DOEpatents

Betts, Jr., William S.; Pickering, J. Larry; Black, William E.

1987-01-01

A thermal barrier/core support for the fuel core of a nuclear reactor having a metallic cylinder secured to the reactor vessel liner and surrounded by fibrous insulation material. A top cap is secured to the upper end of the metallic cylinder that locates and orients a cover block and post seat. Under normal operating conditions, the metallic cylinder supports the entire load exerted by its associated fuel core post. Disposed within the metallic cylinder is a column of ceramic material, the height of which is less than that of the metallic cylinder, and thus is not normally load bearing. In the event of a temperature excursion beyond the design limits of the metallic cylinder and resulting in deformation of the cylinder, the ceramic column will abut the top cap to support the fuel core post.

HOMOGENEOUS NUCLEAR REACTOR

DOEpatents

Hammond, R.P.; Busey, H.M.

1959-02-17

Nuclear reactors of the homogeneous liquid fuel type are discussed. The reactor is comprised of an elongated closed vessel, vertically oriented, having a critical region at the bottom, a lower chimney structure extending from the critical region vertically upwardly and surrounded by heat exchanger coils, to a baffle region above which is located an upper chimney structure containing a catalyst functioning to recombine radiolyticallydissociated moderator gages. In operation the liquid fuel circulates solely by convection from the critical region upwardly through the lower chimney and then downwardly through the heat exchanger to return to the critical region. The gases formed by radiolytic- dissociation of the moderator are carried upwardly with the circulating liquid fuel and past the baffle into the region of the upper chimney where they are recombined by the catalyst and condensed, thence returning through the heat exchanger to the critical region.

Acquisition of gamma camera and physiological data by computer.

PubMed

Hack, S N; Chang, M; Line, B R; Cooper, J A; Robeson, G H

1986-11-01

We have designed, implemented, and tested a new Research Data Acquisition System (RDAS) that permits a general purpose digital computer to acquire signals from both gamma camera sources and physiological signal sources concurrently. This system overcomes the limited multi-source, high speed data acquisition capabilities found in most clinically oriented nuclear medicine computers. The RDAS can simultaneously input signals from up to four gamma camera sources with a throughput of 200 kHz per source and from up to eight physiological signal sources with an aggregate throughput of 50 kHz. Rigorous testing has found the RDAS to exhibit acceptable linearity and timing characteristics. In addition, flood images obtained by this system were compared with flood images acquired by a commercial nuclear medicine computer system. National Electrical Manufacturers Association performance standards of the flood images were found to be comparable.

Detection and evaluation of weld defects in stainless steel using alternating current field measurement

NASA Astrophysics Data System (ADS)

Wei-Li, Ma, Weiping; Pan-Qi, Wen-jiao, Dou; Yuan, Xin'an; Yin, Xiaokang

2018-04-01

Stainless steel is widely used in nuclear power plants, such as various high-radioactive pool, tools storage and fuel transportation channel, and serves as an important barrier to stop the leakage of high-radioactive material. NonDestructive Evaluation (NDE) methods, eddy current testing (ET), ultrasonic examination (UT), penetration testing (PT) and hybrid detection method, etc., have been introduced into the inspection of a nuclear plant. In this paper, the Alternating Current Field Measurement (ACFM) was fully applied to detect and evaluate the defects in the welds of the stainless steel. Simulations were carried out on different defect types, crack lengths, and orientation to reveal the relationship between the signals and dimensions to determine whether methods could be validated by the experiment. A 3-axis ACFM probe was developed and three plates including 16 defects, which served in nuclear plant before, were examined by automatic detection equipment. The result shows that the minimum detectable crack length on the surface is 2mm and ACFM shows excellent inspection results for a weld in stainless steel and gives an encouraging prospect of broader application.

The Nuclear Transport Factor Kap121 Is Required for Stability of the Dam1 Complex and Mitotic Kinetochore Bi-orientation.

PubMed

Cairo, Lucas V; Wozniak, Richard W

2016-03-15

The karyopherin (Kap) family of nuclear transport factors facilitates macromolecular transport through nuclear pore complexes (NPCs). The binding of Kaps to their cargos can also regulate, both temporally and spatially, the interactions of the cargo protein with interacting partners. Here, we show that the essential yeast Kap, Kap121, binds Dam1 and Duo1, components of the microtubule (MT)-associated Dam1 complex required for linking dynamic MT ends with kinetochores (KTs). Like mutations in the Dam1 complex, loss of Kap121 function compromises the formation of normal KT-MT attachments during mitosis. We show that the stability of the Dam1 complex in vivo is dependent on its association with Kap121. Furthermore, we show that the Kap121/Duo1 complex is maintained in the presence of RanGTP but Kap121 is released by the cooperative actions of RanGTP and tubulin. We propose that Kap121 stabilizes the Dam1 complex and participates in escorting it to spindle MTs. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

The effectiveness of 28S and 16S molecular regions in resolving phylogeny of Malaysian microgastrinae (Hymenoptera: Braconidae)

NASA Astrophysics Data System (ADS)

Zuki, Ameyra Aman; Mohammed, Muhamad Azmi; Md-Zain, Badrul Munir; Yaakop, Salmah

2018-04-01

The phylogenetic relationships of Microgastrinae remains unclear though some studies have been conducted to resolve it. The function of Microgastrinae as endoparasitoids of Lepidopteran larvae makes this subfamily an ideal and potential species to be applied as biological control agent of infesting crops. In this study, a total of 13 microgastrine samples under 13 genera were collected from nine localities throughout Peninsular Malaysia. Two molecular regions, 28S nuclear marker and 16S mitochondrial marker were utilized in this study to examine the effectiveness of those regions in resolving the relationships within Microgastrinae. Total of 36 sequences were implemented in the analyses of NJ, MP and Bayesian for both markers. Results obtained from this study were supported by morphological and biological characters. Henceforth, the outcome from this study provides a proof of effectiveness of 28S and 16S molecular markers in studying the phylogenetic relationships of Microgastrinae from Malaysia exclusively and Oriental generally.

Optimal segmentation and packaging process

DOEpatents

Kostelnik, Kevin M.; Meservey, Richard H.; Landon, Mark D.

1999-01-01

A process for improving packaging efficiency uses three dimensional, computer simulated models with various optimization algorithms to determine the optimal segmentation process and packaging configurations based on constraints including container limitations. The present invention is applied to a process for decontaminating, decommissioning (D&D), and remediating a nuclear facility involving the segmentation and packaging of contaminated items in waste containers in order to minimize the number of cuts, maximize packaging density, and reduce worker radiation exposure. A three-dimensional, computer simulated, facility model of the contaminated items are created. The contaminated items are differentiated. The optimal location, orientation and sequence of the segmentation and packaging of the contaminated items is determined using the simulated model, the algorithms, and various constraints including container limitations. The cut locations and orientations are transposed to the simulated model. The contaminated items are actually segmented and packaged. The segmentation and packaging may be simulated beforehand. In addition, the contaminated items may be cataloged and recorded.

Organizational Behavior: A Brief Overview and Safety Orientation.

PubMed

Waller, Mary J

2015-12-01

Organizational Behavior (OB) is a discipline of social science that seeks explanations for human behavior in organizations. OB draws on core disciplines such as psychology, sociology, anthropology, economics, communication, and law to create and investigate multilevel explanations of why people engage in particular behaviors, and which behaviors under which circumstances lead to better outcomes in organizations. Created using an applied or pragmatic lens and tested with a wide range of both quantitative and qualitative methodologies, most OB theories and research have direct implications for managers and for other organizational participants. Not surprisingly, one focal area of OB research concerns safety in organizations, and a growing body of safety-oriented literature in OB is based on data collected during simulation training across a variety of organizations such as hospitals, airlines, nuclear power plants, and other high reliability organizations. Copyright © 2015 Mosby, Inc. All rights reserved.

Crossed-coil detection of two-photon excited nuclear quadrupole resonance

NASA Astrophysics Data System (ADS)

Eles, Philip T.; Michal, Carl A.

2005-08-01

Applying a recently developed theoretical framework for determining two-photon excitation Hamiltonians using average Hamiltonian theory, we calculate the excitation produced by half-resonant irradiation of the pure quadrupole resonance of a spin-3/2 system. This formalism provides expressions for the single-quantum and double-quantum nutation frequencies as well as the Bloch-Siegert shift. The dependence of the excitation strength on RF field orientation and the appearance of the free-induction signal along an axis perpendicular to the excitation field provide an unmistakable signature of two-photon excitation. We demonstrate single- and double-quantum excitation in an axially symmetric system using 35Cl in a single crystal of potassium chlorate ( ωQ = 28 MHz) with crossed-coil detection. A rotation plot verifies the orientation dependence of the two-photon excitation, and double-quantum coherences are observed directly with the application of a static external magnetic field.

High-level waste disposal, ethics and thermodynamics

NASA Astrophysics Data System (ADS)

Schwartz, Michael O.

2008-06-01

Moral philosophy applied to nuclear waste disposal can be linked to paradigmatic science. Simple thermodynamic principles tell us something about rightness or wrongness of our action. Ethical judgement can be orientated towards the chemical compatibility between waste container and geological repository. A container-repository system as close as possible to thermodynamic equilibrium is ethically acceptable. It aims at unlimited stability, similar to the stability of natural metal deposits within the Earth’s crust. The practicability of the guideline can be demonstrated.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Y.W.; Labouriau, A.; Taylor, C.M.

Dynamics and structure of tri-n-butyltin fluoride in n-hexane solutions were probed using (tin-119) nuclear magnetic resonance spin relaxation methodologies. Significant relaxation-induced polarization transfer effects were observed and exploited. The experimental observations indicate that the tri-n-butyl fluoride exists in a polymeric form in solution. For a 0.10% (w/w) solution at 25 [degree]C, NMR reveals significant orientational/exchange relaxation on both the microsecond and nanosecond time scales. Solution-state and solid-state parameters are compared and contrasted. 26 refs., 3 figs., 1 tab.

Biologically relevant conformational features of linear and cyclic proteolipid protein (PLP) peptide analogues obtained by high-resolution nuclear magnetic resonance and molecular dynamics

NASA Astrophysics Data System (ADS)

Kordopati, Golfo G.; Tzoupis, Haralambos; Troganis, Anastassios N.; Tsivgoulis, Gerasimos M.; Golic Grdadolnik, Simona; Simal, Carmen; Tselios, Theodore V.

2017-09-01

Proteolipid protein (PLP) is one of the main proteins of myelin sheath that are destroyed during the progress of multiple sclerosis (MS). The immunodominant PLP139-151 epitope is known to induce experimental autoimmune encephalomyelitis (EAE, animal model of MS), wherein residues 144 and 147 are recognized by T cell receptor (TCR) during the formation of trimolecular complex with peptide-antigen and major histocompability complex. The conformational behavior of linear and cyclic peptide analogues of PLP, namely PLP139-151 and cyclic (139-151) (L144, R147) PLP139-151, have been studied in solution by means of nuclear magnetic resonance (NMR) methods in combination with unrestrained molecular dynamics simulations. The results indicate that the side chains of mutated amino acids in the cyclic analogue have different spatial orientation compared with the corresponding side chains of the linear analogue, which can lead to reduced affinity to TCR. NMR experiments combined with theoretical calculations pave the way for the design and synthesis of potent restricted peptides of immunodominant PLP139-151 epitope as well as non peptide mimetics that rises as an ultimate goal.

Watching hydrogen-bond dynamics in a β-turn by transient two-dimensional infrared spectroscopy

NASA Astrophysics Data System (ADS)

Kolano, Christoph; Helbing, Jan; Kozinski, Mariusz; Sander, Wolfram; Hamm, Peter

2006-11-01

X-ray crystallography and nuclear magnetic resonance measurements provide us with atomically resolved structures of an ever-growing number of biomolecules. These static structural snapshots are important to our understanding of biomolecular function, but real biomolecules are dynamic entities that often exploit conformational changes and transient molecular interactions to perform their tasks. Nuclear magnetic resonance methods can follow such structural changes, but only on millisecond timescales under non-equilibrium conditions. Time-resolved X-ray crystallography has recently been used to monitor the photodissociation of CO from myoglobin on a subnanosecond timescale, yet remains challenging to apply more widely. In contrast, two-dimensional infrared spectroscopy, which maps vibrational coupling between molecular groups and hence their relative positions and orientations, is now routinely used to study equilibrium processes on picosecond timescales. Here we show that the extension of this method into the non-equilibrium regime allows us to observe in real time in a short peptide the weakening of an intramolecular hydrogen bond and concomitant opening of a β-turn. We find that the rate of this process is two orders of magnitude faster than the `folding speed limit' established for contact formation between protein side chains.

POU2F2-oriented network promotes human gastric cancer metastasis

PubMed Central

Wang, Si-Meng; Tie, Jun; Wang, Wen-Lan; Hu, Si-Jun; Yin, Ji-Peng; Yi, Xiao-Fang; Tian, Zu-Hong; Zhang, Xiang-Yuan; Li, Meng-Bin; Li, Zeng-Shan; Nie, Yong-Zhan; Wu, Kai-Chun; Fan, Dai-Ming

2016-01-01

Background and aims Aberrant upregulation of POU2F2 expression has been discovered in metastatic gastric cancer (GC). However, the mechanisms underlying the aberrant upregulation and the potential functions of POU2F2 remain uncertain. Design The role and mechanism of POU2F2 in GC metastasis were investigated in gastric epithelial cells, GC cell lines and an experimental metastasis animal model by gain of function and loss of function. Upstream and downstream targets of POU2F2 were selected by bioinformatics and identified by luciferase reporter assay, electrophoretic mobility shift assay and chromatin immunoprecipitation PCR. The influence of miR-218 on its putative target genes (POU2F2, ROBO1 and IKK-β) and GC metastasis was further explored via in vitro and in vivo approaches. Results Increased POU2F2 expression was detected in metastatic GC cell lines and patient samples. POU2F2 was induced by the activation of nuclear factor (NF)-κB and, in turn, regulated ROBO1 transcription, thus functionally contributing to GC metastasis. Finally, miR-218 was found to suppress GC metastasis by simultaneously mediating multiple molecules in the POU2F2-oriented network. Conclusions This study demonstrated that NF-κB and the SLIT2/ROBO1 interaction network with POU2F2 as the central part may exert critical effects on tumour metastasis. Blocking the activation of the POU2F2-oriented metastasis network using miR-218 precursors exemplified a promising approach that sheds light on new strategies for GC treatment. PMID:26019213

Conceptual design of a thermalhydraulic loop for multiple test geometries at supercritical conditions named Supercritical Phenomena Experimental Test Apparatus (SPETA)

NASA Astrophysics Data System (ADS)

Adenariwo, Adepoju

The efficiency of nuclear reactors can be improved by increasing the operating pressure of current nuclear reactors. Current CANDU-type nuclear reactors use heavy water as coolant at an outlet pressure of up to 11.5 MPa. Conceptual SuperCritical Water Reactors (SCWRs) will operate at a higher coolant outlet pressure of 25 MPa. Supercritical water technology has been used in advanced coal plants and its application proves promising to be employed in nuclear reactors. To better understand how supercritical water technology can be applied in nuclear power plants, supercritical water loops are used to study the heat transfer phenomena as it applies to CANDU-type reactors. A conceptual design of a loop known as the Supercritical Phenomena Experimental Apparatus (SPETA) has been done. This loop has been designed to fit in a 9 m by 2 m by 2.8 m enclosure that will be installed at the University of Ontario Institute of Technology Energy Research Laboratory. The loop include components to safely start up and shut down various test sections, produce a heat source to the test section, and to remove reject heat. It is expected that loop will be able to investigate the behaviour of supercritical water in various geometries including bare tubes, annulus tubes, and multi-element-type bundles. The experimental geometries are designed to match the fluid properties of Canadian SCWR fuel channel designs so that they are representative of a practical application of supercritical water technology in nuclear plants. This loop will investigate various test section orientations which are the horizontal, vertical, and inclined to investigate buoyancy effects. Frictional pressure drop effects and satisfactory methods of estimating hydraulic resistances in supercritical fluid shall also be estimated with the loop. Operating limits for SPETA have been established to be able to capture the important heat transfer phenomena at supercritical conditions. Heat balance and flow calculations have been done to appropriately size components in the loop. Sensitivity analysis has been done to find the optimum design for the loop.

Q-Band Electron-Nuclear Double Resonance Reveals Out-of-Plane Hydrogen Bonds Stabilize an Anionic Ubisemiquinone in Cytochrome bo3 from Escherichia coli.

PubMed

Sun, Chang; Taguchi, Alexander T; Vermaas, Josh V; Beal, Nathan J; O'Malley, Patrick J; Tajkhorshid, Emad; Gennis, Robert B; Dikanov, Sergei A

2016-10-11

The respiratory cytochrome bo 3 ubiquinol oxidase from Escherichia coli has a high-affinity ubiquinone binding site that stabilizes the one-electron reduced ubisemiquinone (SQ H ), which is a transient intermediate during the electron-mediated reduction of O 2 to water. It is known that SQ H is stabilized by two strong hydrogen bonds from R71 and D75 to ubiquinone carbonyl oxygen O1 and weak hydrogen bonds from H98 and Q101 to O4. In this work, SQ H was investigated with orientation-selective Q-band (∼34 GHz) pulsed 1 H electron-nuclear double resonance (ENDOR) spectroscopy on fully deuterated cytochrome (cyt) bo 3 in a H 2 O solvent so that only exchangeable protons contribute to the observed ENDOR spectra. Simulations of the experimental ENDOR spectra provided the principal values and directions of the hyperfine (hfi) tensors for the two strongly coupled H-bond protons (H1 and H2). For H1, the largest principal component of the proton anisotropic hfi tensor T z' = 11.8 MHz, whereas for H2, T z' = 8.6 MHz. Remarkably, the data show that the direction of the H1 H-bond is nearly perpendicular to the quinone plane (∼70° out of plane). The orientation of the second strong hydrogen bond, H2, is out of plane by ∼25°. Equilibrium molecular dynamics simulations on a membrane-embedded model of the cyt bo 3 Q H site show that these H-bond orientations are plausible but do not distinguish which H-bond, from R71 or D75, is nearly perpendicular to the quinone ring. Density functional theory calculations support the idea that the distances and geometries of the H-bonds to the ubiquinone carbonyl oxygens, along with the measured proton anisotropic hfi couplings, are most compatible with an anionic (deprotonated) ubisemiquinone.

Integration of 3D Printed and Micropatterned Polycaprolactone Scaffolds for Guidance of Oriented Collagenous Tissue Formation In Vivo.

PubMed

Pilipchuk, Sophia P; Monje, Alberto; Jiao, Yizu; Hao, Jie; Kruger, Laura; Flanagan, Colleen L; Hollister, Scott J; Giannobile, William V

2016-03-01

Scaffold design incorporating multiscale cues for clinically relevant, aligned tissue regeneration has potential to improve structural and functional integrity of multitissue interfaces. The objective of this preclinical study is to develop poly(ε-caprolactone) (PCL) scaffolds with mesoscale and microscale architectural cues specific to human ligament progenitor cells and assess their ability to form aligned bone-ligament-cementum complexes in vivo. PCL scaffolds are designed to integrate a 3D printed bone region with a micropatterned PCL thin film consisting of grooved pillars. The patterned film region is seeded with human ligament cells, fibroblasts transduced with bone morphogenetic protein-7 genes seeded within the bone region, and a tooth dentin segment positioned on the ligament region prior to subcutaneous implantation into a murine model. Results indicate increased tissue alignment in vivo using micropatterned PCL films, compared to random-porous PCL. At week 6, 30 μm groove depth significantly enhances oriented collagen fiber thickness, overall cell alignment, and nuclear elongation relative to 10 μm groove depth. This study demonstrates for the first time that scaffolds with combined hierarchical mesoscale and microscale features can align cells in vivo for oral tissue repair with potential for improving the regenerative response of other bone-ligament complexes. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Effect of hydrogenation conditions on the microstructure and mechanical properties of zirconium hydride

NASA Astrophysics Data System (ADS)

Muta, Hiroaki; Nishikane, Ryoji; Ando, Yusuke; Matsunaga, Junji; Sakamoto, Kan; Harjo, Stefanus; Kawasaki, Takuro; Ohishi, Yuji; Kurosaki, Ken; Yamanaka, Shinsuke

2018-03-01

Precipitation of brittle zirconium hydrides deteriorate the fracture toughness of the fuel cladding tubes of light water reactor. Although the hydride embrittlement has been studied extensively, little is known about physical properties of the hydride due to the experimental difficulties. In the present study, to elucidate relationship between mechanical properties and microstructure, two δ-phase zirconium hydrides and one ε-phase zirconium hydride were carefully fabricated considering volume changes at the metal-to-hydride transformation. The δ-hydride that was fabricated from α-zirconium exhibits numerous inner cracks due to the large volume change. Analyses of the neutron diffraction pattern and electron backscatter diffraction (EBSD) data show that the sample displays significant stacking faults in the {111} plane and in the pseudo-layered microstructure. On the other hand, the δ-hydride sample fabricated from β-zirconium at a higher temperature displays equiaxed grains and no cracks. The strong crystal orientation dependence of mechanical properties were confirmed by indentation test and EBSD observation. The δ-hydride hydrogenated from α-zirconium displays a lower Young's modulus than that prepared from β-zirconium. The difference is attributed to stacking faults within the {111} plane, for which the Young's modulus exhibits the highest value in the perpendicular direction. The strong influence of the crystal orientation and dislocation density on the mechanical properties should be considered when evaluating hydride precipitates in nuclear fuel cladding.

Theoretical investigations of open-shell systems: 1. Spectral simulation of the 2s(2)p(2) (2)D <- 2s(2)2p (2)P(o) valence transition in the boron diargon cluster, and 2. Quantum Monte Carlo calculations of boron in solid molecular hydrogen

NASA Astrophysics Data System (ADS)

Krumrine, Jennifer Rebecca

This dissertation is concerned in part with the construction of accurate pairwise potentials, based on reliable ab initio potential energy surfaces (PES's), which are fully anisotropic in the sense that multiple PES's are accessible to systems with orientational electronic properties. We have carried out several investigations of B (2s 22p 2Po) with spherical ligands: (1)an investigation of the electronic spectrum of the BAr2 complex and (2)two related studies of the equilibrium properties and spectral simulation of B embedded in solid pH 2. Our investigations suggest that it cannot be assumed that nuclear motion in an open-shell system occurs on a single PES. The 2s2p2 2 D <-- 2s22p 2Po valence transition in the BAr 2 cluster is investigated. The electronic transition within BAr 2 is modeled theoretically; the excited potential energy surfaces of the five-fold degenerate B(2s2p2 2D) state within the ternary complex are computed using a pairwise-additive model. A collaborative path integral molecular dynamics investigation of the equilibrium properties of boron trapped in solid para-hydrogen (pH2) and a path integral Monte Carlo spectral simulation. Using fully anisotropic pair potentials, coupling of the electronic and nuclear degrees of freedom is observed, and is found to be an essential feature in understanding the behavior and determining the energy of the impure solid, especially in highly anisotropic matrices. We employ the variational Monte Carlo method to further study the behavior of ground state B embedded in solid pH2. When a boron atom exists in a substitutional site in a lattice, the anisotropic distortion of the local lattice plays a minimal role in the energetics. However, when a nearest neighbor vacancy is present along with the boron impurity, two phenomena are found to influence the behavior of the impure quantum solid: (1)orientation of the 2p orbital to minimize the energy of the impurity and (2)distortion of the local lattice structure to promote an energetically favorable nuclear configuration. This research was supported by the Joint Program for Atomic, Molecular and Optical Science sponsored by the University of Maryland at College Park and the National Insititute of Standards and Technology, and by the U.S. Air Force Office of Scientific Research. (Abstract shortened by UMI.)

Advanced Fuels Campaign FY 2014 Accomplishments Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Braase, Lori; May, W. Edgar

The mission of the Advanced Fuels Campaign (AFC) is to perform Research, Development, and Demonstration (RD&D) activities for advanced fuel forms (including cladding) to enhance the performance and safety of the nation’s current and future reactors; enhance proliferation resistance of nuclear fuel; effectively utilize nuclear energy resources; and address the longer-term waste management challenges. This includes development of a state-of-the art Research and Development (R&D) infrastructure to support the use of a “goal-oriented science-based approach.” In support of the Fuel Cycle Research and Development (FCRD) program, AFC is responsible for developing advanced fuels technologies to support the various fuel cyclemore » options defined in the Department of Energy (DOE) Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. AFC uses a “goal-oriented, science-based approach” aimed at a fundamental understanding of fuel and cladding fabrication methods and performance under irradiation, enabling the pursuit of multiple fuel forms for future fuel cycle options. This approach includes fundamental experiments, theory, and advanced modeling and simulation. The modeling and simulation activities for fuel performance are carried out under the Nuclear Energy Advanced Modeling and Simulation (NEAMS) program, which is closely coordinated with AFC. In this report, the word “fuel” is used generically to include fuels, targets, and their associated cladding materials. R&D of light water reactor (LWR) fuels with enhanced accident tolerance is also conducted by AFC. These fuel systems are designed to achieve significantly higher fuel and plant performance to allow operation to significantly higher burnup, and to provide enhanced safety during design basis and beyond design basis accident conditions. The overarching goal is to develop advanced nuclear fuels and materials that are robust, have high performance capability, and are more tolerant to accident conditions than traditional fuel systems. AFC management and integration activities included continued support for international collaborations, primarily with France, Japan, the European Union, Republic of Korea, and China, as well as various working group and expert group activities in the Organization for Economic Cooperation and Development Nuclear Energy Agency (OECD-NEA) and the International Atomic Energy Agency (IAEA). Three industry-led Funding Opportunity Announcements (FOAs) and two university-led Integrated Research Projects (IRPs), funded in 2013, made significant progress in fuels and materials development. All are closely integrated with AFC and Accident Tolerant Fuels (ATF) research. Accomplishments made during fiscal year (FY) 2014 are highlighted in this report, which focuses on completed work and results. The process details leading up to the results are not included; however, the lead technical contact is provided for each section.« less

Small-molecule modulators of PXR and CAR

PubMed Central

Chai, Sergio C.; Cherian, Milu T.; Wang, Yue-Ming; Chen, Taosheng

2016-01-01

Two nuclear receptors, the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR), participate in the xenobiotic detoxification system by regulating the expression of drug-metabolizing enzymes and transporters in order to degrade and excrete foreign chemicals or endogenous metabolites. This review aims to expand the perceived relevance of PXR and CAR beyond their established role as master xenosensors to disease-oriented areas, emphasizing their modulation by small molecules. Structural studies of these receptors have provided much-needed insight into the nature of their binding promiscuity and the important elements that lead to ligand binding. Reports of species- and isoform-selective activation highlight the need for further scrutiny when extrapolating from animal data to humans, as animal models are at the forefront of early drug discovery. PMID:26921498

Numerical Simulation of Metallic Uranium Sintering

NASA Astrophysics Data System (ADS)

Berry, Bruce

Conventional ceramic oxide nuclear fuels are limited in their thermal and life-cycle properties. The desire to operate at higher burnups as is required by current utility economics has proven a formidable challenge for oxide fuel designs. Metallic formulations have superior thermal performance but are plagued by volumetric swelling due to fission gas buildup. In this study, we consider a number of specific microstructure configurations that have been experimentally shown to exhibit considerable resistance to porosity loss. Specifically, a void sizing that is bimodally distributed was shown to resist early pore loss and could provide collection sites for fission gas buildup. We employ the phase field model of Cahn and Hilliard, solved via the finite element method using the open source Multi-User Object Oriented Simulation Environment (MOOSE) developed by INL.

ELECTRON MICROSCOPY OF MITOSIS IN AMEBAE

PubMed Central

Roth, L. E.

1967-01-01

The mitotic apparatus (MA) of the giant ameba, Chaos carolinensis, has characteristic sequences of microtubule arrays and deployment of nuclear envelope fragments. If mitotic organisms are subjected to 2°C for 5 min, the MA microtubules are completely degraded, and the envelope fragments are released from the chromosomes which remain condensed but lose their metaphase-plate orientation. On warming, microtubules reform but show partial loss of their parallel alignment; displacement of the envelope fragments persists or is increased by microtubule reformation. This study demonstrates that cooling causes destruction of microtubules and intermicrotubular cross-bonds and further shows that such controlled dissolution and reformation can provide an in vivo test sequence for studies on the effects of inhibitor-compounds on microtubule subunit aggregation. Urea, at the comparatively low concentration of 0.8 M, inhibited reformation following cooling and rewarming but was ineffective in altering microtubules that had formed before treatment. PMID:6040537

Modeling of Austenite Grain Growth During Austenitization in a Low Alloy Steel

NASA Astrophysics Data System (ADS)

Dong, Dingqian; Chen, Fei; Cui, Zhenshan

2016-01-01

The main purpose of this work is to develop a pragmatic model to predict austenite grain growth in a nuclear reactor pressure vessel steel. Austenite grain growth kinetics has been investigated under different heating conditions, involving heating temperature, holding time, as well as heating rate. Based on the experimental results, the mathematical model was established by regression analysis. The model predictions present a good agreement with the experimental data. Meanwhile, grain boundary precipitates and pinning effects on grain growth were studied by transmission electron microscopy. It is found that with the increasing of the temperature, the second-phase particles tend to be dissolved and the pinning effects become smaller, which results in a rapid growth of certain large grains with favorable orientation. The results from this study provide the basis for the establishment of large-sized ingot heating specification for SA508-III steel.

Crystal orientation effects on helium ion depth distributions and adatom formation processes in plasma-facing tungsten

DOE PAGES

Hammond, Karl D.; Wirth, Brian D.

2014-10-09

Here, we present atomistic simulations that show the effect of surface orientation on helium depth distributions and surface feature formation as a result of low-energy helium plasma exposure. We find a pronounced effect of surface orientation on the initial depth of implanted helium ions, as well as a difference in reflection and helium retention across different surface orientations. Our results indicate that single helium interstitials are sufficient to induce the formation of adatom/substitutional helium pairs under certain highly corrugated tungsten surfaces, such as {1 1 1}-orientations, leading to the formation of a relatively concentrated layer of immobile helium immediately belowmore » the surface. The energies involved for helium-induced adatom formation on {1 1 1} and {2 1 1} surfaces are exoergic for even a single adatom very close to the surface, while {0 0 1} and {0 1 1} surfaces require two or even three helium atoms in a cluster before a substitutional helium cluster and adatom will form with reasonable probability. This phenomenon results in much higher initial helium retention during helium plasma exposure to {1 1 1} and {2 1 1} tungsten surfaces than is observed for {0 0 1} or {0 1 1} surfaces and is much higher than can be attributed to differences in the initial depth distributions alone. Lastly, the layer thus formed may serve as nucleation sites for further bubble formation and growth or as a source of material embrittlement or fatigue, which may have implications for the formation of tungsten “fuzz” in plasma-facing divertors for magnetic-confinement nuclear fusion reactors and/or the lifetime of such divertors.« less

Dimension changing phase transitions in instanton crystals

NASA Astrophysics Data System (ADS)

Kaplunovsky, Vadim; Sonnenschein, Jacob

2014-04-01

We investigate lattices of instantons and the dimension-changing transitions between them. Our ultimate goal is the 3D → 4D transition, which is holographically dual to the phase transition between the baryonic and the quarkyonic phases of cold nuclear matter. However, in this paper (just as in [1]) we focus on lower dimensions — the 1D lattice of instantons in a harmonic potential V ∝ , and the zigzag-shaped lattice as a first stage of the 1D → 2D transition. We prove that in the low- and moderate-density regimes, interactions between the instantons are dominated by two-body forces. This drastically simplifies finding the ground state of the instantons' orientations, so we made a numeric scan of the whole orientation space instead of assuming any particular ansatz. We find that depending on the M 2 /M 3 /M 4 ratios, the ground state of instanton orientations can follow a wide variety of patterns. For the straight 1D lattices, we found orientations periodically running over elements of a , Klein, prismatic, or dihedral subgroup of the , as well as irrational but link-periodic patterns. For the zigzag-shaped lattices, we detected 4 distinct orientation phases — the anti-ferromagnet, another abelian phase, and two non-abelian phases. Allowing the zigzag amplitude to vary as a function of increasing compression force, we obtained the phase diagrams for the straight and zigzag-shaped lattices in the (force , M 3 /M 4), (chemical potential , M 3 /M 4), and (density , M 3 /M 4) planes. Some of the transitions between these phases are second-order while others are first-order. Our techniques can be applied to other types of non-abelian crystals.

The chicken skeletal alpha-actin gene promoter region exhibits partial dyad symmetry and a capacity to drive bidirectional transcription.

PubMed Central

Grichnik, J M; French, B A; Schwartz, R J

1988-01-01

The chicken skeletal alpha-actin gene promoter region (-202 to -12) provides myogenic transcriptional specificity. This promoter contains partial dyad symmetry about an axis at nucleotide -108 and in transfection experiments is capable of directing transcription in a bidirectional manner. At least three different transcription initiation start sites, oriented toward upstream sequences, were mapped 25 to 30 base pairs from TATA-like regions. The opposing transcriptional activity was potentiated upon the deletion of sequences proximal to the alpha-actin transcription start site. Thus, sequences which serve to position RNA polymerase for alpha-actin transcription may allow, in their absence, the selection of alternative and reverse-oriented start sites. Nuclear runoff transcription assays of embryonic muscle indicated that divergent transcription may occur in vivo but with rapid turnover of nuclear transcripts. Divergent transcriptional activity enabled us to define the 3' regulatory boundary of the skeletal alpha-actin promoter which retains a high level of myogenic transcriptional activity. The 3' regulatory border was detected when serial 3' deletions bisected the element (-91 CCAAA TATGG -82) which reduced transcriptional activity by 80%. Previously we showed that disruption of its upstream counterpart (-127 CCAAAGAAGG -136) resulted in about a 90% decrease in activity. These element pairs, which we describe as CCAAT box-associated repeats, are conserved in all sequenced vertebrate sarcomeric actin genes and may act in a cooperative manner to facilitate transcription in myogenic cells. Images PMID:3211124

Conventional and Bimodal Nuclear Thermal Rocket (NTR) Artificial Gravity Mars Transfer Vehicle Concepts

NASA Technical Reports Server (NTRS)

Borowski, Stanley K.; McCurdy, David R.; Packard, Thomas W.

2016-01-01

A variety of countermeasures have been developed to address the debilitating physiological effects of zero-gravity (0-g) experienced by cosmonauts and astronauts during their approximately 0.5 to 1.2 year long stays in low Earth orbit (LEO). Longer interplanetary flights, combined with possible prolonged stays in Mars orbit, could subject crewmembers to up to approximately 2.5 years of weightlessness. In view of known and recently diagnosed problems associated with 0-g, an artificial gravity (AG) spacecraft offers many advantages and may indeed be an enabling technology for human flights to Mars. A number of important human factors must be taken into account in selecting the rotation radius, rotation rate, and orientation of the habitation module or modules. These factors include the gravity gradient effect, radial and tangential Coriolis forces, along with cross-coupled acceleration effects. Artificial gravity Mars transfer vehicle (MTV) concepts are presented that utilize both conventional NTR, as well as, enhanced bimodal nuclear thermal rocket (BNTR) propulsion. The NTR is a proven technology that generates high thrust and has a specific impulse (Isp) capability of approximately 900 s-twice that of today's best chemical rockets. The AG/MTV concepts using conventional Nuclear Thermal Propulsion (NTP) carry twin cylindrical International Space Station (ISS)- type habitation modules with their long axes oriented either perpendicular or parallel to the longitudinal spin axis of the MTV and utilize photovoltaic arrays (PVAs) for spacecraft power. The twin habitat modules are connected to a central operations hub located at the front of the MTV via two pressurized tunnels that provide the rotation radius for the habitat modules. For the BNTR AG/MTV option, each engine has its own closed secondary helium(He)-xenon (Xe) gas loop and Brayton Rotating Unit (BRU) that can generate 10s of kilowatts (kWe) of spacecraft electrical power during the mission coast phase eliminating the need for large PVAs. A single inflatable TransHab-type habitation module is also used with multiple vertical floors oriented radial to the MTV spin axis. The BNTR MTV's geometry-long and linear-is naturally compatible with AG operation. By rotating the vehicle about its center-of-mass (CM) and perpendicular to its flight vector at approximately 3.0 to 5.2 rpm, a centrifugal force and AG environment corresponding to approximately 0.38 to 1.0 g can be established to help maintain crew fitness out to Mars and back. Vehicles using NTP/ Bimodal Nuclear Thermal Propulsion (BNTP) can more readily accommodate the heavier payload mass and increased RCS propellant loading associated with AG operation, and can travel faster to and from Mars thereby reducing the crew's exposure to galactic cosmic radiation and solar flares. Mission scenario descriptions, key vehicle features and operational characteristics for each propulsion option are presented using the lift capability and payload volumes estimated for the Space Launch System (SLS)-1B and followon Heavy Lift Vehicle (HLV).

Evolution of Binary Supermassive Black Holes in Rotating Nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rasskazov, Alexander; Merritt, David

The interaction of a binary supermassive black hole with stars in a galactic nucleus can result in changes to all the elements of the binary’s orbit, including the angles that define its orientation. If the nucleus is rotating, the orientation changes can be large, causing large changes in the binary’s orbital eccentricity as well. We present a general treatment of this problem based on the Fokker–Planck equation for f , defined as the probability distribution for the binary’s orbital elements. First- and second-order diffusion coefficients are derived for the orbital elements of the binary using numerical scattering experiments, and analyticmore » approximations are presented for some of these coefficients. Solutions of the Fokker–Planck equation are then derived under various assumptions about the initial rotational state of the nucleus and the binary hardening rate. We find that the evolution of the orbital elements can become qualitatively different when we introduce nuclear rotation: (1) the orientation of the binary’s orbit evolves toward alignment with the plane of rotation of the nucleus and (2) binary orbital eccentricity decreases for aligned binaries and increases for counteraligned ones. We find that the diffusive (random-walk) component of a binary’s evolution is small in nuclei with non-negligible rotation, and we derive the time-evolution equations for the semimajor axis, eccentricity, and inclination in that approximation. The aforementioned effects could influence gravitational wave production as well as the relative orientation of host galaxies and radio jets.« less

Managing emergencies and abnormal situations in air traffic control (part II): teamwork strategies.

PubMed

Malakis, Stathis; Kontogiannis, Tom; Kirwan, Barry

2010-07-01

Team performance has been studied in many safety-critical organizations including aviation, nuclear power plant, offshore oil platforms and health organizations. This study looks into teamwork strategies that air traffic controllers employ to manage emergencies and abnormal situations. Two field studies were carried out in the form of observations of simulator training in emergency and unusual scenarios of novices and experienced controllers. Teamwork strategies covered aspects of team orientation and coordination, information exchange, change management and error handling. Several performance metrics were used to rate the efficiency of teamwork and test the construct validity of a prototype model of teamwork. This is a companion study to an earlier investigation of taskwork strategies in the same field (part I) and contributes to the development of a generic model for Taskwork and Teamwork strategies in Emergencies in Air traffic Management (T(2)EAM). Suggestions are made on how to use T(2)EAM to develop training programs, assess team performance and improve mishap investigations. Copyright 2010 Elsevier Ltd. All rights reserved.

3D Motions of Iron in Six-Coordinate {FeNO} 7 Hemes by Nuclear Resonance Vibration Spectroscopy [3-D Motions of Iron in Six-coordinate {FeNO} 7 Hemes by NRVS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, Qian; Pavlik, Jeffrey W.; Silvernail, Nathan J.

The vibrational spectrum of a six-coordinate nitrosyl iron porphyrinate, monoclinic [Fe(T pFPP)(1-MeIm)(NO)] (T pFPP = tetra- para-fluorophenylporphyrin; 1-MeIm=1-methylimidazole), has been studied by oriented single-crystal nuclear resonance vibrational spectroscopy (NRVS). The crystal was oriented to give spectra perpendicular to the porphyrin plane and two in-plane spectra perpendicular or parallel to the projection of the FeNO plane. These enable assignment of the FeNO bending and stretching modes. The measurements reveal that the two in-plane spectra have substantial differences that result from the strongly bonded axial NO ligand. The direction of the in-plane iron motion is found to be largely parallel and perpendicularmore » to the projection of the bent FeNO on the porphyrin plane. The out-of-plane Fe-N-O stretching and bending modes are strongly mixed with each other, as well as with porphyrin ligand modes. The stretch is mixed with v 50 as was also observed for dioxygen complexes. The frequency of the assigned stretching mode of eight Fe-X-O (X= N, C, and O) complexes is correlated with the Fe XO bond lengths. The nature of highest frequency band at ≈560 cm -1 has also been examined in two additional new derivatives. Previously assigned as the Fe NO stretch (by resonance Raman), it is better described as the bend, as the motion of the central nitrogen atom of the FeNO group is very large. There is significant mixing of this mode. In conclusion, the results emphasize the importance of mode mixing; the extent of mixing must be related to the peripheral phenyl substituents.« less

3D Motions of Iron in Six-Coordinate {FeNO} 7 Hemes by Nuclear Resonance Vibration Spectroscopy [3-D Motions of Iron in Six-coordinate {FeNO} 7 Hemes by NRVS

DOE PAGES

Peng, Qian; Pavlik, Jeffrey W.; Silvernail, Nathan J.; ...

2016-03-21

The vibrational spectrum of a six-coordinate nitrosyl iron porphyrinate, monoclinic [Fe(T pFPP)(1-MeIm)(NO)] (T pFPP = tetra- para-fluorophenylporphyrin; 1-MeIm=1-methylimidazole), has been studied by oriented single-crystal nuclear resonance vibrational spectroscopy (NRVS). The crystal was oriented to give spectra perpendicular to the porphyrin plane and two in-plane spectra perpendicular or parallel to the projection of the FeNO plane. These enable assignment of the FeNO bending and stretching modes. The measurements reveal that the two in-plane spectra have substantial differences that result from the strongly bonded axial NO ligand. The direction of the in-plane iron motion is found to be largely parallel and perpendicularmore » to the projection of the bent FeNO on the porphyrin plane. The out-of-plane Fe-N-O stretching and bending modes are strongly mixed with each other, as well as with porphyrin ligand modes. The stretch is mixed with v 50 as was also observed for dioxygen complexes. The frequency of the assigned stretching mode of eight Fe-X-O (X= N, C, and O) complexes is correlated with the Fe XO bond lengths. The nature of highest frequency band at ≈560 cm -1 has also been examined in two additional new derivatives. Previously assigned as the Fe NO stretch (by resonance Raman), it is better described as the bend, as the motion of the central nitrogen atom of the FeNO group is very large. There is significant mixing of this mode. In conclusion, the results emphasize the importance of mode mixing; the extent of mixing must be related to the peripheral phenyl substituents.« less

(Limiting the greenhouse effect)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fulkerson, W.

1991-01-10

The Dahlem Conference on controlling CO{sub 2} in the atmosphere focused on research needs broadly defined. The RD D needs discussed tended to be social-institutional rather than technically oriented perhaps because of the propensity of most attendees, but many important ideas emerged, including those related to questions on technology adoption by both developed, emerging, or transition economics. The European attendees appeared to be strongly devoted to reducing emissions, and doing it soon using efficiency improvement and ultimately renewables. The importance of efficiency improvement was universally accepted, but the extent to which it can be relied upon is a major uncertaintymore » for everyone except the most zealous. There was no detailed discussion of what could be done to encourage the more rapid adoption of renewables. Most attendees seemed to have discounted nuclear, but, at any rate, the problems of reviving nuclear worldwide were not discussed in detail.« less

Multiple stable states of a periodically driven electron spin in a quantum dot using circularly polarized light

NASA Astrophysics Data System (ADS)

Korenev, V. L.

2011-06-01

The periodical modulation of circularly polarized light with a frequency close to the electron spin resonance frequency induces a sharp change of the single electron spin orientation. Hyperfine interaction provides a feedback, thus fixing the precession frequency of the electron spin in the external and the Overhauser field near the modulation frequency. The nuclear polarization is bidirectional and the electron-nuclear spin system (ENSS) possesses a few stable states. The same physics underlie the frequency-locking effect for two-color and mode-locked excitations. However, the pulsed excitation with mode-locked laser brings about the multitudes of stable states in ENSS in a quantum dot. The resulting precession frequencies of the electron spin differ in these states by the multiple of the modulation frequency. Under such conditions ENSS represents a digital frequency converter with more than 100 stable channels.

A digital acquisition and elaboration system for nuclear fast pulse detection

NASA Astrophysics Data System (ADS)

Esposito, B.; Riva, M.; Marocco, D.; Kaschuck, Y.

2007-03-01

A new digital acquisition and elaboration system has been developed and assembled in ENEA-Frascati for the direct sampling of fast pulses from nuclear detectors such as scintillators and diamond detectors. The system is capable of performing the digital sampling of the pulses (200 MSamples/s, 14-bit) and the simultaneous (compressed) data transfer for further storage and software elaboration. The design (FPGA-based) is oriented to real-time applications and has been developed in order to allow acquisition with no loss of pulses and data storage for long-time intervals (tens of s at MHz pulse count rates) without the need of large on-board memory. A dedicated pulse analysis software, written in LabVIEWTM, performs the treatment of the acquired pulses, including pulse recognition, pile-up rejection, baseline removal, pulse shape particle separation and pulse height spectra analysis. The acquisition and pre-elaboration programs have been fully integrated with the analysis software.

Centromere pairing precedes meiotic chromosome pairing in plants.

PubMed

Zhang, Jing; Han, Fangpu

2017-11-01

Meiosis is a specialized eukaryotic cell division, in which diploid cells undergo a single round of DNA replication and two rounds of nuclear division to produce haploid gametes. In most eukaryotes, the core events of meiotic prophase I are chromosomal pairing, synapsis and recombination. To ensure accurate chromosomal segregation, homologs have to identify and align along each other at the onset of meiosis. Although much progress has been made in elucidating meiotic processes, information on the mechanisms underlying chromosome pairing is limited in contrast to the meiotic recombination and synapsis events. Recent research in many organisms indicated that centromere interactions during early meiotic prophase facilitate homologous chromosome pairing, and functional centromere is a prerequisite for centromere pairing such as in maize. Here, we summarize the recent achievements of chromosome pairing research on plants and other organisms, and outline centromere interactions, nuclear chromosome orientation, and meiotic cohesin, as main determinants of chromosome pairing in early meiotic prophase.

Dynamical approach to fusion-fission process in superheavy mass region

NASA Astrophysics Data System (ADS)

Aritomo, Y.; Hinde, D. J.; Wakhle, A.; du Rietz, R.; Dasgupta, M.; Hagino, K.; Chiba, S.; Nishio, K.

2012-10-01

In order to describe heavy-ion fusion reactions around the Coulomb barrier with an actinide target nucleus, we propose a model which combines the coupled-channels approach and a fluctuation-dissipation model for dynamical calculations. This model takes into account couplings to the collective states of the interacting nuclei in the penetration of the Coulomb barrier and the subsequent dynamical evolution of a nuclear shape from the contact configuration. In the fluctuation-dissipation model with a Langevin equation, the effect of nuclear orientation at the initial impact on the prolately deformed target nucleus is considered. Fusion-fission, quasifission and deep quasifission are separated as different Langevin trajectories on the potential energy surface. Using this model, we analyze the experimental data for the mass distribution of fission fragments (MDFF) in the reaction of 36S+238U at several incident energies around the Coulomb barrier.

Organizational/institutional factors affecting performance in the nuclear power industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benson, J.L.

1992-01-01

The dramatic macro experiences occurring at Three Mile Island and Chernobyl as well as the cumulative micro experiences represented by sky-rocketing costs and public concerns have demonstrated how the institutionally and organizationally related aspects of the nuclear power industry have dominated and shaped the technical ones. Further, given the relatively stable or evolutionary nature of the technology as it is currently applied, these institutional and organizational factors contain the roots of most of the complications/problems associated with the industry relative to achieving any or all of its future performance objectives (technical, economic, and safety). Some technology transfer was attempted bymore » the author from the field of general systems/cybernetics, which was explicitly aimed at dealing with the organizational/institutional factors, i.e., the problems and issues were approached using principles and methodology substantially different from that typically seen from applications based on the more traditional paradigmic engineering/industrial management orientation.« less

Time encoded radiation imaging

DOEpatents

Marleau, Peter; Brubaker, Erik; Kiff, Scott

2014-10-21

The various technologies presented herein relate to detecting nuclear material at a large stand-off distance. An imaging system is presented which can detect nuclear material by utilizing time encoded imaging relating to maximum and minimum radiation particle counts rates. The imaging system is integrated with a data acquisition system that can utilize variations in photon pulse shape to discriminate between neutron and gamma-ray interactions. Modulation in the detected neutron count rates as a function of the angular orientation of the detector due to attenuation of neighboring detectors is utilized to reconstruct the neutron source distribution over 360 degrees around the imaging system. Neutrons (e.g., fast neutrons) and/or gamma-rays are incident upon scintillation material in the imager, the photons generated by the scintillation material are converted to electrical energy from which the respective neutrons/gamma rays can be determined and, accordingly, a direction to, and the location of, a radiation source identified.

Preliminary research on eddy current bobbin quantitative test for heat exchange tube in nuclear power plant

NASA Astrophysics Data System (ADS)

Qi, Pan; Shao, Wenbin; Liao, Shusheng

2016-02-01

For quantitative defects detection research on heat transfer tube in nuclear power plants (NPP), two parts of work are carried out based on the crack as the main research objects. (1) Production optimization of calibration tube. Firstly, ASME, RSEM and homemade crack calibration tubes are applied to quantitatively analyze the defects depth on other designed crack test tubes, and then the judgment with quantitative results under crack calibration tube with more accuracy is given. Base on that, weight analysis of influence factors for crack depth quantitative test such as crack orientation, length, volume and so on can be undertaken, which will optimize manufacture technology of calibration tubes. (2) Quantitative optimization of crack depth. Neural network model with multi-calibration curve adopted to optimize natural crack test depth generated in in-service tubes shows preliminary ability to improve quantitative accuracy.

Polarity-defective mutants of Aspergillus nidulans.

PubMed

Osherov, N; Mathew, J; May, G S

2000-12-01

We have identified two polarity-defective (pod) mutants in Aspergillus nidulans from a collection of heat-sensitive lethal mutants. At restrictive temperature, these mutants are capable of nuclear division but are unable to establish polar hyphal growth. We cloned the two pod genes by complementation of their heat-sensitive lethal phenotypes. The libraries used to clone the pod genes are under the control of the bidirectional niaD and niiA promoters. Complementation of the pod mutants is dependent on growth on inducing medium. We show that rescue of the heat-sensitive phenotype on inducing media is independent of the orientation of the gene relative to the niaD or niiA promoters, demonstrating that the intergenic region between the niaD and the niiA genes functions as an orientation-independent enhancer and repressor that is capable of functioning over long distances. The products of the podG and the podH genes were identified as homologues of the alpha subunit of yeast mitochondrial phenylalanyl--tRNA synthetase and transcription factor IIF interacting component of the CTD phosphatase. Neither of these gene products would have been predicted to produce a pod mutant phenotype based on studies of cellular polarity mutants in other organisms. The implications of these results are discussed. Copyright 2000 Academic Press.

Off-resonance NOVEL

NASA Astrophysics Data System (ADS)

Jain, Sheetal K.; Mathies, Guinevere; Griffin, Robert G.

2017-10-01

Dynamic nuclear polarization (DNP) is theoretically able to enhance the signal in nuclear magnetic resonance (NMR) experiments by a factor γe/γn, where γ 's are the gyromagnetic ratios of an electron and a nuclear spin. However, DNP enhancements currently achieved in high-field, high-resolution biomolecular magic-angle spinning NMR are well below this limit because the continuous-wave DNP mechanisms employed in these experiments scale as ω0-n where n ˜ 1-2. In pulsed DNP methods, such as nuclear orientation via electron spin-locking (NOVEL), the DNP efficiency is independent of the strength of the main magnetic field. Hence, these methods represent a viable alternative approach for enhancing nuclear signals. At 0.35 T, the NOVEL scheme was demonstrated to be efficient in samples doped with stable radicals, generating 1H NMR enhancements of ˜430. However, an impediment in the implementation of NOVEL at high fields is the requirement of sufficient microwave power to fulfill the on-resonance matching condition, ω0I = ω1S, where ω0I and ω1S are the nuclear Larmor and electron Rabi frequencies, respectively. Here, we exploit a generalized matching condition, which states that the effective Rabi frequency, ω1S e f f, matches ω0I. By using this generalized off-resonance matching condition, we generate 1H NMR signal enhancement factors of 266 (˜70% of the on-resonance NOVEL enhancement) with ω1S/2π = 5 MHz. We investigate experimentally the conditions for optimal transfer of polarization from electrons to 1H both for the NOVEL mechanism and the solid-effect mechanism and provide a unified theoretical description for these two historically distinct forms of DNP.

A fifth major genetic group among honeybees revealed in Syria

PubMed Central

2013-01-01

Background Apiculture has been practiced in North Africa and the Middle-East from antiquity. Several thousand years of selective breeding have left a mosaic of Apis mellifera subspecies in the Middle-East, many uniquely adapted and survived to local environmental conditions. In this study we explore the genetic diversity of A. mellifera from Syria (n = 1258), Lebanon (n = 169) and Iraq (n = 35) based on 14 short tandem repeat (STR) loci in the context of reference populations from throughout the Old World (n = 732). Results Our data suggest that the Syrian honeybee Apis mellifera syriaca occurs in both Syrian and Lebanese territories, with no significant genetic variability between respective populations from Syria and Lebanon. All studied populations clustered within a new fifth independent nuclear cluster, congruent with an mtDNA Z haplotype identified in a previous study. Syrian honeybee populations are not associated with Oriental lineage O, except for sporadic introgression into some populations close to the Turkish and Iraqi borders. Southern Syrian and Lebanese populations demonstrated high levels of genetic diversity compared to the northern populations. Conclusion This study revealed the effects of foreign queen importations on Syrian bee populations, especially for the region of Tartus, where extensive introgression of A. m. anatolica and/or A. m. caucasica alleles were identified. The policy of creating genetic conservation centers for the Syrian subspecies should take into consideration the influence of the oriental lineage O from the northern Syrian border and the large population of genetically divergent indigenous honeybees located in southern Syria. PMID:24314104

Magnetohydrodynamical Effects on Nuclear Deflagration Fronts in Type Ia Supernovae

NASA Astrophysics Data System (ADS)

Hristov, Boyan; Collins, David C.; Hoeflich, Peter; Weatherford, Charles A.; Diamond, Tiara R.

2018-05-01

This article presents a study of the effects of magnetic fields on non-distributed nuclear burning fronts as a possible solution to a fundamental problem for the thermonuclear explosion of a Chandrasekhar mass ({M}Ch}) white dwarf (WD), the currently favored scenario for the majority of Type Ia SNe. All existing 3D hydrodynamical simulations predict strong global mixing of the burning products due to Rayleigh–Taylor (RT) instabilities, which contradicts observations. As a first step toward studying the flame physics, we present a set of computational magnet-hydrodynamic models in rectangular flux tubes, resembling a small inner region of a WD. We consider initial magnetic fields up to {10}12 {{G}} of various orientations. We find an increasing suppression of RT instabilities starting at about {10}9 {{G}}. The front speed tends to decrease with increasing magnitude up to about {10}11 {{G}}. For even higher fields new small-scale, finger-like structures develop, which increase the burning speed by a factor of 3 to 4 above the field-free RT-dominated regime. We suggest that the new instability may provide sufficiently accelerated energy production during the distributed burning regime to go over the Chapman–Jougey limit and trigger a detonation. Finally, we discuss the possible origins of high magnetic fields during the final stage of the progenitor evolution or the explosion.

Effect of orientation on deformation behavior of Fe nanowires: A molecular dynamics study

NASA Astrophysics Data System (ADS)

Sainath, G.; Srinivasan, V. S.; Choudhary, B. K.; Mathew, M. D.; Jayakumar, T.

2014-04-01

Molecular dynamics simulations have been carried out to study the effect of crystal orientation on tensile deformation behaviour of single crystal BCC Fe nanowires at 10 K. Two nanowires with an initial orientation of <100>/{100} and <110>/{111} have been chosen for this study. The simulation results show that the deformation mechanisms varied with crystal orientation. The nanowire with an initial orientation of <100>/{100} deforms predominantly by twinning mechanism, whereas the nanowire oriented in <110>/{111}, deforms by dislocation plasticity. In addition, the single crystal oriented in <110>/{111} shows higher strength and elastic modulus than <100>/{100} oriented nanowire.

[Psychometric evaluation of the Coach Orientation Questionnaire with a Spanish sample of handball coaches].

PubMed

Feu, Sebastián; Ibáñez, Sergio José; Graça, Amândio; Sampaio, Jaime

2007-11-01

The purpose of this study was to develop a questionnaire to investigate volleyball coaches' orientations toward the coaching process. The study was preceded by four developmental stages in order to improve user understanding, validate the content, and refine the psychometric properties of the instrument. Participants for the reliability and validity study were 334 Spanish volleyball team coaches, 86.5% men and 13.2% women. The following 6 factors emerged from the exploratory factor analysis: team-work orientation, technological orientation, innovative orientation, dialogue orientation, directive orientation, and social climate orientation. Statistical results indicated that the instrument produced reliable and valid scores in all the obtained factors (a> .70), showing that this questionnaire is a useful tool to examine coaches' orientations towards coaching.

Vulnerability assessment of a space based weapon platform electronic system exposed to a thermonuclear weapon detonation

NASA Astrophysics Data System (ADS)

Perez, C. L.; Johnson, J. O.

Rapidly changing world events, the increased number of nations with inter-continental ballistic missile capability, and the proliferation of nuclear weapon technology will increase the number of nuclear threats facing the world today. Monitoring these nation's activities and providing an early warning and/or intercept system via reconnaissance and surveillance satellites and space based weapon platforms is a viable deterrent against a surprise nuclear attack. However, the deployment of satellite and weapon platform assets in space will subject the sensitive electronic equipment to a variety of natural and man-made radiation environments. These include Van Allen Belt protons and electrons; galactic and solar flare protons; and neutrons, gamma rays, and x-rays from intentionally detonated fission and fusion weapons. In this paper, the MASH vl.0 code system is used to estimate the dose to the critical electronics components of an idealized space based weapon platform from neutron and gamma-ray radiation emitted from a thermonuclear weapon detonation in space. Fluence and dose assessments were performed for the platform fully loaded, and in several stages representing limited engagement scenarios. The results indicate vulnerabilities to the Command, Control, and Communication bay instruments from radiation damage for a nuclear weapon detonation for certain source/platform orientations. The distance at which damage occurs will depend on the weapon yield (n,(gamma)/kiloton) and size (kilotons).

Pro-Social Goals in Achievement Situations: Amity Goal Orientation Enhances the Positive Effects of Mastery Goal Orientation.

PubMed

Levontin, Liat; Bardi, Anat

2018-04-01

Research has neglected the utility of pro-social goals within achievement situations. In this article, four studies demonstrate that amity goal orientation, promoting mutual success of oneself together with others, enhances the utility of mastery goal orientation. We demonstrate this in longitudinally predicting performance (Studies 1 and 2) and in maintaining motivation after a disappointing performance (Studies 3 and 4). The studies demonstrate the same interaction effect in academic and in work achievement contexts. Specifically, whereas amity goal orientation did not predict achievement on its own, it enhanced the positive effect of mastery goal orientation. Together, these studies establish the importance of amity goal orientation while also advancing our understanding of the effects of other achievement goal orientations. We suggest future directions in examining the utility of amity goals in other contexts.

Nuclear Blast Response Computer Program. Volume I. Program Description.

DTIC Science & Technology

1981-08-01

VEL 13 - AAS / , \\ / I ’ / I 4 2 Y VERTICAL PLANE NRMAL ’ , TO XAAs 3 / / , / 12 -’C’- Figure 6. Blast Orientations for Aero Module The spacing of...lag across 75 ’ " -0- Zi I ,AAS \\ \\ &,8 (8) VEgrrCA PLANE S .NORMAL TO YAAS XAAS VEL / ) - . +/ f \\ " 4 (4) 2 (2) 3 (3) Corresponding Aero...DEFINITION CDIl I Li NTFM-MXOPD ANUM TEMPORARY ARRAYS FOP 2 L2 NTFM-MXOFD ADEN FORMING TRANSFEF 3 L3 2-MXCRE ATEN FUNCTION POLYNOMIALS 4 L4 2.MXCRE

Space nuclear power applied to electric propulsion

NASA Technical Reports Server (NTRS)

Vicente, F. A.; Karras, T.; Darooka, D.; Isenberg, L.

1989-01-01

Space reactor power systems with characteristics ideal for advanced spacecraft systems applications are discussed. These characteristics are: high power-to-weight ratio (15 to 33 W/kg); high volume density (high ballistic coefficient); no preferential orientation in orbit; long operational life; high reliability; and total launch and operational safety. These characteristics allow the use of electric propulsion to raise spacecraft from low earth parking orbits to operational orbits, greatly increasing the useful orbit payload for a given launch vehicle by eliminating the need for a separation injection stage. A proposed demonstration mission is described.

NMR spectrum analysis for CrAs at ambient pressure

NASA Astrophysics Data System (ADS)

Kotegawa, H.; Nakahara, S.; Matsushima, K.; Tou, H.; Matsuoka, E.; Sugawara, H.; Harima, H.

2018-05-01

We report NMR spectrum analysis for CrAs, which was recently reported to be superconducting under pressure. The NMR spectrum obtained by the powdered single crystals shows a typical powder pattern reproduced by the electric field gradient (EFG) parameters and isotropic Knight shift, indicating anisotropy of Knight shift is not remarkable in CrAs. For the oriented sample, the spectrum can be understood by considering that the crystals are aligned for H ∥ b . The temperature dependence of Knight shift was successfully obtained from NMR spectrum with large nuclear quadrupole interaction.

Pulsed ENDOR Determination of Relative Orientation of g- and Molecular-Frames of Imidazole-Coordinated Heme Center of iNOS

PubMed Central

Astashkin, Andrei V.; Fan, Weihong; Elmore, Bradley O.; Guillemette, J. Guy; Feng, Changjian

2011-01-01

Mammalian nitric oxide synthase (NOS) is a flavo-hemoprotein that catalyzes the oxidation of L-arginine to nitric oxide. Information about the relative alignment of the heme and FMN domains of NOS is important for understanding the electron transfer between the heme and FMN centers, but no crystal structure data for NOS holoenzyme are available. In our previous work [Astashkin, A. V.; Elmore, B. O.; Fan, W.; Guillemette, J. G.; Feng, C. J. Am. Chem. Soc. 2010, 132, 12059–12067], the distance between the imidazole-coordinated low-spin Fe(III) heme and FMN semiquinone in a human inducible NOS (iNOS) oxygenase/FMN construct has been determined by pulsed electron paramagnetic resonance (EPR). The orientation of the Fe – FMN radius-vector, RFe-FMN, with respect to the heme g-frame was also determined. In the present study, pulsed electron-nuclear double resonance (ENDOR) investigation of the deuterons at carbons C2 and C5 in the deuterated coordinated imidazole was used to determine the relative orientation of the heme g- and molecular frames, from which RFe-FMN can be referenced to the heme molecular frame. Numerical simulations of the ENDOR spectra showed that the g-factor axis corresponding to the low-field EPR turning point is perpendicular to the heme plane, while the axis corresponding to the high-field turning point is in the heme plane and makes an angle of about 80° with the coordinated imidazole plane. The FMN-heme domain docking model obtained in the previous work was found to be in qualitative agreement with the combined experimental results of the two pulsed EPR works. PMID:21834532

Investigation of Local Structures in Cation-ordered Microwave Dielectric A Solid-state NMR and First Principle Calculation Study

NASA Astrophysics Data System (ADS)

Kalfarisi, Rony G.

Solid-state Nuclear Magnetic Resonance (ssNMR) spectroscopy has proven to be a powerful method to probe the local structure and dynamics of a system. In powdered solids, the nuclear spins experience various anisotropic interactions which depend on the molecular orientation. These anisotropic interactions make ssNMR very useful as they give a specific appearance to the resonance lines of the spectra. The position and shape of these resonance lines can be related to local structure and dynamics of the system under study. My research interest has focused around studying local structures and dynamics of quadrupolar nuclei in materials using ssNMR spectroscopy. 7Li and 93Nb ssNMR magic angle spinning (MAS) spectra, acquired at 17.6 and 7.06 T, have been used to evaluate the structural and dynamical properties of cation-ordered microwave dielectric materials. Microwave dielectric materials are essential in the application of wireless telecommunication, biomedical engineering, and other scientific and industrial implementations that use radio and microwave signals. The study of the local environment with respect to average structure, such as X-ray diffraction study, is essential for the better understanding of the correlations between structures and properties of these materials. The investigation for short and medium range can be performed with the use of ssNMR techniques. Even though XRD results show cationic ordering at the B-site (third coordination sphere), NMR spectra show a presence of disorder materials. This was indicated by the observation of a distribution in NMR parameters derived from experimental . {93}Nb NMR spectraand supported by theoretical calculations.

[Digitalization of radiological imaging information and consequences for patient care in the hospital ].

PubMed

den Heeten, G J; Barneveld Binkhuysen, F H

2001-08-25

Determining the rate at which radiology must be digitalised has been a controversial issue for many years. Much radiological information is still obtained from the film-screen combination (X-rays) with all of its known inherent restrictions. The importance of imaging information in the healthcare process continues to increase for both radiologists and referring physicians, and the ongoing developments in information technology means that it is possible to integrate imaging information and electronic patient files. The healthcare process can only become more effective and efficient when the appropriate information is in the right place at the right time, something that conventional methods, using photos that need to be physically moved, can scarcely satisfy. There is also a desire for integration with information obtained from nuclear medicine, pathology and endoscopy, and eventually of all stand-alone data systems with relevance for the individually oriented hospital healthcare. The transition from a conventional to a digital process is complex; it is accompanied by the transition from a data-oriented to a process-oriented system. Many years have already been invested in the integration of information systems and the development of digital systems within radiology, the current performance of which is such that many hospitals are considering the digitalisation process or are already implementing parts of it.

Interpolation by fast Wigner transform for rapid calculations of magnetic resonance spectra from powders.

PubMed

Stevensson, Baltzar; Edén, Mattias

2011-03-28

We introduce a novel interpolation strategy, based on nonequispaced fast transforms involving spherical harmonics or Wigner functions, for efficient calculations of powder spectra in (nuclear) magnetic resonance spectroscopy. The fast Wigner transform (FWT) interpolation operates by minimizing the time-consuming calculation stages, by sampling over a small number of Gaussian spherical quadrature (GSQ) orientations that are exploited to determine the spectral frequencies and amplitudes from a 10-70 times larger GSQ set. This results in almost the same orientational averaging accuracy as if the expanded grid was utilized explicitly in an order of magnitude slower computation. FWT interpolation is applicable to spectral simulations involving any time-independent or time-dependent and noncommuting spin Hamiltonian. We further show that the merging of FWT interpolation with the well-established ASG procedure of Alderman, Solum and Grant [J. Chem. Phys. 134, 3717 (1986)] speeds up simulations by 2-7 times relative to using ASG alone (besides greatly extending its scope of application), and between 1-2 orders of magnitude compared to direct orientational averaging in the absence of interpolation. Demonstrations of efficient spectral simulations are given for several magic-angle spinning scenarios in NMR, encompassing half-integer quadrupolar spins and homonuclear dipolar-coupled (13)C systems.

Does cultural exposure partially explain the association between personality and political orientation?

PubMed

Xu, Xiaowen; Mar, Raymond A; Peterson, Jordan B

2013-11-01

Differences in political orientation are partly rooted in personality, with liberalism predicted by Openness to Experience and conservatism by Conscientiousness. Since Openness is positively associated with intellectual and creative activities, these may help shape political orientation. We examined whether exposure to cultural activities and historical knowledge mediates the relationship between personality and political orientation. Specifically, we examined the mediational role of print exposure (Study 1), film exposure (Study 2), and knowledge of American history (Study 3). Studies 1 and 2 found that print and film exposure mediated the relationships Openness to Experience and Conscientiousness have with political orientation. In Study 3, knowledge of American history mediated the relationship between Openness and political orientation, but not the association between Conscientiousness and political orientation. Exposure to culture, and a corollary of this exposure in the form of acquiring knowledge, can therefore partially explain the associations between personality and political orientation.

The Importance of International Technical Nuclear Forensics to Deter Illicit Trafficking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, D K

2007-01-30

Illicit trafficking of nuclear materials is a transboundary problem that requires a cooperative approach involving international nuclear forensics to ensure all states understand the threat posed by nuclear smuggling as well as a means to best deter the movement of nuclear contraband. To achieve the objectives, all cases involving illicit trafficking of nuclear and radiological materials must be vigorously pursued and prosecuted when appropriate. The importance of outreach and formal government-to-government relationships with partner nations affected by nuclear trafficking cannot be under-estimated. States that are situated on smuggling routes may be well motivated to counter nuclear crimes to bolster theirmore » own border and transportation security as well as strengthen their economic and political viability. National law enforcement and atomic energy agencies in these states are aggressively pursuing a comprehensive strategy to counter nuclear smuggling through increasing reliance on technical nuclear forensics. As part of these activities, it is essential that these organizations be given adequate orientation to the best practices in this emerging discipline including the categorization of interdicted nuclear material, collection of traditional and nuclear forensic evidence, data analysis using optimized analytical protocols, and how to best fuse forensics information with reliable case input to best develop a law enforcement or national security response. The purpose of formalized USG relationship is to establish an institutional framework for collaboration in international forensics, improve standards of forensics practice, conduct joint exercises, and pursue case-work that benefits international security objectives. Just as outreach and formalized relationships are important to cultivate international nuclear forensics, linking nuclear forensics to ongoing national assistance in border and transpiration security, including port of entry of entry monitoring, nuclear safeguards, and emerging civilian nuclear power initiatives including the Global Nuclear Energy Partnership are crucial components of a successful nuclear detection and security architecture. Once illicit shipments of nuclear material are discovered at a border, the immediate next question will be the nature and the source of the material, as well as the identity of the individual(s) involved in the transfer as well as their motivations. The Nuclear Smuggling International Technical Working Group (ITWG) is a forum for the first responder, law enforcement, policy, and diplomatic community to partner with nuclear forensics experts worldwide to identify requirements and develop technical solutions in common. The ITWG was charted in 1996 and since that time approximately 30 member states and organizations have participated in 11 annual international meetings. The ITWG also works closely with the IAEA to provide countries with support for forensic analyses. Priorities include the development of common protocols for the collection of nuclear forensic evidence and laboratory investigations, organization of forensic round-robin analytical exercises and technical forensic assistance to requesting nations. To promote the science of nuclear forensics within the ITWG the Nuclear Forensics Laboratory Group was organized in 2004. A Model Action Plan for nuclear forensics was developed by the ITWG and published as an IAEA Nuclear security Series document to guide member states in their own forensics investigations. Through outreach, formalized partnerships, common approaches and security architectures, and international working groups, nuclear forensics provides an important contribution to promoting nuclear security and accountability.« less

Study of Heavy-ion Induced Fission for Heavy Element Synthesis

NASA Astrophysics Data System (ADS)

Nishio, K.; Ikezoe, H.; Hofmann, S.; Ackermann, D.; Aritomo, Y.; Comas, V. F.; Düllmann, Ch. E.; Heinz, S.; Heredia, J. A.; Heßberger, F. P.; Hirose, K.; Khuyagbaatar, J.; Kindler, B.; Kojouharov, I.; Lommel, B.; Makii, M.; Mann, R.; Mitsuoka, S.; Nishinaka, I.; Ohtsuki, T.; Saro, S.; Schädel, M.; Popeko, A. G.; Türler, A.; Wakabayashi, Y.; Watanabe, Y.; Yakushev, A.; Yeremin, A.

2014-05-01

Fission fragment mass distributions were measured in heavy-ion induced fission of 238U. The mass distributions changed drastically with incident energy. The results are explained by a change of the ratio between fusion and quasifission with nuclear orientation. A calculation based on a fluctuation dissipation model reproduced the mass distributions and their incident energy dependence. Fusion probability was determined in the analysis. Evaporation residue cross sections were calculated with a statistical model for the reactions of 30Si+238U and 34S+238U using the obtained fusion probability in the entrance channel. The results agree with the measured cross sections of 263,264Sg and 267,268Hs, produced by 30Si+238U and 34S+238U, respectively. It is also suggested that sub-barrier energies can be used for heavy element synthesis.

Actomyosin contractility rotates the cell nucleus

PubMed Central

Kumar, Abhishek; Maitra, Ananyo; Sumit, Madhuresh; Ramaswamy, Sriram; Shivashankar, G. V.

2014-01-01

The cell nucleus functions amidst active cytoskeletal filaments, but its response to their contractile stresses is largely unexplored. We study the dynamics of the nuclei of single fibroblasts, with cell migration suppressed by plating onto micro-fabricated patterns. We find the nucleus undergoes noisy but coherent rotational motion. We account for this observation through a hydrodynamic approach, treating the nucleus as a highly viscous inclusion residing in a less viscous fluid of orientable filaments endowed with active stresses. Lowering actin contractility selectively by introducing blebbistatin at low concentrations drastically reduced the speed and coherence of the angular motion of the nucleus. Time-lapse imaging of actin revealed a correlated hydrodynamic flow around the nucleus, with profile and magnitude consistent with the results of our theoretical approach. Coherent intracellular flows and consequent nuclear rotation thus appear to be an intrinsic property of cells. PMID:24445418

Actomyosin contractility rotates the cell nucleus.

PubMed

Kumar, Abhishek; Maitra, Ananyo; Sumit, Madhuresh; Ramaswamy, Sriram; Shivashankar, G V

2014-01-21

The cell nucleus functions amidst active cytoskeletal filaments, but its response to their contractile stresses is largely unexplored. We study the dynamics of the nuclei of single fibroblasts, with cell migration suppressed by plating onto micro-fabricated patterns. We find the nucleus undergoes noisy but coherent rotational motion. We account for this observation through a hydrodynamic approach, treating the nucleus as a highly viscous inclusion residing in a less viscous fluid of orientable filaments endowed with active stresses. Lowering actin contractility selectively by introducing blebbistatin at low concentrations drastically reduced the speed and coherence of the angular motion of the nucleus. Time-lapse imaging of actin revealed a correlated hydrodynamic flow around the nucleus, with profile and magnitude consistent with the results of our theoretical approach. Coherent intracellular flows and consequent nuclear rotation thus appear to be an intrinsic property of cells.

Identification of ortho-Substituted Benzoic Acid/Ester Derivatives via the Gas-Phase Neighboring Group Participation Effect in (+)-ESI High Resolution Mass Spectrometry.

PubMed

Blincoe, William D; Rodriguez-Granillo, Agustina; Saurí, Josep; Pierson, Nicholas A; Joyce, Leo A; Mangion, Ian; Sheng, Huaming

2018-04-01

Benzoic acid/ester/amide derivatives are common moieties in pharmaceutical compounds and present a challenge in positional isomer identification by traditional tandem mass spectrometric analysis. A method is presented for exploiting the gas-phase neighboring group participation (NGP) effect to differentiate ortho-substituted benzoic acid/ester derivatives with high resolution mass spectrometry (HRMS 1 ). Significant water/alcohol loss (>30% abundance in MS 1 spectra) was observed for ortho-substituted nucleophilic groups; these fragment peaks are not observable for the corresponding para and meta-substituted analogs. Experiments were also extended to the analysis of two intermediates in the synthesis of suvorexant (Belsomra) with additional analysis conducted with nuclear magnetic resonance (NMR), density functional theory (DFT), and ion mobility spectrometry-mass spectrometry (IMS-MS) studies. Significant water/alcohol loss was also observed for 1-substituted 1, 2, 3-triazoles but not for the isomeric 2-substituted 1, 2, 3-triazole analogs. IMS-MS, NMR, and DFT studies were conducted to show that the preferred orientation of the 2-substituted triazole rotamer was away from the electrophilic center of the reaction, whereas the 1-subtituted triazole was oriented in close proximity to the center. Abundance of NGP product was determined to be a product of three factors: (1) proton affinity of the nucleophilic group; (2) steric impact of the nucleophile; and (3) proximity of the nucleophile to carboxylic acid/ester functional groups. Graphical Abstract ᅟ.

Identification of ortho-Substituted Benzoic Acid/Ester Derivatives via the Gas-Phase Neighboring Group Participation Effect in (+)-ESI High Resolution Mass Spectrometry

NASA Astrophysics Data System (ADS)

Blincoe, William D.; Rodriguez-Granillo, Agustina; Saurí, Josep; Pierson, Nicholas A.; Joyce, Leo A.; Mangion, Ian; Sheng, Huaming

2018-02-01

Benzoic acid/ester/amide derivatives are common moieties in pharmaceutical compounds and present a challenge in positional isomer identification by traditional tandem mass spectrometric analysis. A method is presented for exploiting the gas-phase neighboring group participation (NGP) effect to differentiate ortho-substituted benzoic acid/ester derivatives with high resolution mass spectrometry (HRMS1). Significant water/alcohol loss (>30% abundance in MS1 spectra) was observed for ortho-substituted nucleophilic groups; these fragment peaks are not observable for the corresponding para and meta-substituted analogs. Experiments were also extended to the analysis of two intermediates in the synthesis of suvorexant (Belsomra) with additional analysis conducted with nuclear magnetic resonance (NMR), density functional theory (DFT), and ion mobility spectrometry-mass spectrometry (IMS-MS) studies. Significant water/alcohol loss was also observed for 1-substituted 1, 2, 3-triazoles but not for the isomeric 2-substituted 1, 2, 3-triazole analogs. IMS-MS, NMR, and DFT studies were conducted to show that the preferred orientation of the 2-substituted triazole rotamer was away from the electrophilic center of the reaction, whereas the 1-subtituted triazole was oriented in close proximity to the center. Abundance of NGP product was determined to be a product of three factors: (1) proton affinity of the nucleophilic group; (2) steric impact of the nucleophile; and (3) proximity of the nucleophile to carboxylic acid/ester functional groups. [Figure not available: see fulltext.

The Bologna complete sample of nearby radio sources. II. Phase referenced observations of faint nuclear sources

NASA Astrophysics Data System (ADS)

Liuzzo, E.; Giovannini, G.; Giroletti, M.; Taylor, G. B.

2009-10-01

Aims: To study statistical properties of different classes of sources, it is necessary to observe a sample that is free of selection effects. To do this, we initiated a project to observe a complete sample of radio galaxies selected from the B2 Catalogue of Radio Sources and the Third Cambridge Revised Catalogue (3CR), with no selection constraint on the nuclear properties. We named this sample “the Bologna Complete Sample” (BCS). Methods: We present new VLBI observations at 5 and 1.6 GHz for 33 sources drawn from a sample not biased toward orientation. By combining these data with those in the literature, information on the parsec-scale morphology is available for a total of 76 of 94 radio sources with a range in radio power and kiloparsec-scale morphologies. Results: The fraction of two-sided sources at milliarcsecond resolution is high (30%), compared to the fraction found in VLBI surveys selected at centimeter wavelengths, as expected from the predictions of unified models. The parsec-scale jets are generally found to be straight and to line up with the kiloparsec-scale jets. A few peculiar sources are discussed in detail. Tables 1-4 are only available in electronic form at http://www.aanda.org

Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells.

PubMed

Ruan, H; Zhan, Y Y; Hou, J; Xu, B; Chen, B; Tian, Y; Wu, D; Zhao, Y; Zhang, Y; Chen, X; Mi, P; Zhang, L; Zhang, S; Wang, X; Cao, H; Zhang, W; Wang, H; Li, H; Su, Y; Zhang, X K; Hu, T

2017-12-14

Berberine, an isoquinoline alkaloid, is a traditional oriental medicine used to treat diarrhea and gastroenteritis. Recently, we reported that it could inhibit the growth of intestinal polyp in animals and in patients with the familial adenomatous polyposis by downregulating β-catenin signaling. However, the intracellular target mediating the effects of berberine remains elusive. Here, we provide evidence that berberine inhibits β-catenin function via directly binding to a unique region comprising residues Gln275, Arg316 and Arg371 in nuclear receptor retinoid X receptor alpha (RXRα), where berberine concomitantly binding to and synergistically activating RXRα with 9-cis-retinoic acid (9-cis-RA), a natural ligand binding to the classical ligand-binding pocket of RXRα. Berberine binding promotes RXRα interaction with nuclear β-catenin, leading to c-Cbl mediated degradation of β-catenin, and consequently inhibits the proliferation of colon cancer cells. Furthermore, berberine suppresses the growth of human colon carcinoma xenograft in nude mice in an RXRα-dependent manner. Together, our study not only identifies RXRα as a direct protein target for berberine but also dissects their binding mode and validates that berberine indeed suppresses β-catenin signaling and cell growth in colon cancer via binding RXRα, which provide new strategies for the design of new RXRα-based antitumor agents and drug combinations.

Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells

PubMed Central

Ruan, H; Zhan, Y Y; Hou, J; Xu, B; Chen, B; Tian, Y; Wu, D; Zhao, Y; Zhang, Y; Chen, X; Mi, P; Zhang, L; Zhang, S; Wang, X; Cao, H; Zhang, W; Wang, H; Li, H; Su, Y; Zhang, X K; Hu, T

2017-01-01

Berberine, an isoquinoline alkaloid, is a traditional oriental medicine used to treat diarrhea and gastroenteritis. Recently, we reported that it could inhibit the growth of intestinal polyp in animals and in patients with the familial adenomatous polyposis by downregulating β-catenin signaling. However, the intracellular target mediating the effects of berberine remains elusive. Here, we provide evidence that berberine inhibits β-catenin function via directly binding to a unique region comprising residues Gln275, Arg316 and Arg371 in nuclear receptor retinoid X receptor alpha (RXRα), where berberine concomitantly binding to and synergistically activating RXRα with 9-cis-retinoic acid (9-cis-RA), a natural ligand binding to the classical ligand-binding pocket of RXRα. Berberine binding promotes RXRα interaction with nuclear β-catenin, leading to c-Cbl mediated degradation of β-catenin, and consequently inhibits the proliferation of colon cancer cells. Furthermore, berberine suppresses the growth of human colon carcinoma xenograft in nude mice in an RXRα-dependent manner. Together, our study not only identifies RXRα as a direct protein target for berberine but also dissects their binding mode and validates that berberine indeed suppresses β-catenin signaling and cell growth in colon cancer via binding RXRα, which provide new strategies for the design of new RXRα-based antitumor agents and drug combinations. PMID:28846104

Optimal segmentation and packaging process

DOEpatents

Kostelnik, K.M.; Meservey, R.H.; Landon, M.D.

1999-08-10

A process for improving packaging efficiency uses three dimensional, computer simulated models with various optimization algorithms to determine the optimal segmentation process and packaging configurations based on constraints including container limitations. The present invention is applied to a process for decontaminating, decommissioning (D and D), and remediating a nuclear facility involving the segmentation and packaging of contaminated items in waste containers in order to minimize the number of cuts, maximize packaging density, and reduce worker radiation exposure. A three-dimensional, computer simulated, facility model of the contaminated items are created. The contaminated items are differentiated. The optimal location, orientation and sequence of the segmentation and packaging of the contaminated items is determined using the simulated model, the algorithms, and various constraints including container limitations. The cut locations and orientations are transposed to the simulated model. The contaminated items are actually segmented and packaged. The segmentation and packaging may be simulated beforehand. In addition, the contaminated items may be cataloged and recorded. 3 figs.

Enhanced light extraction of plastic scintillator using large-area photonic crystal structures fabricated by hot embossing.

PubMed

Chen, Xueye; Liu, Bo; Wu, Qiang; Zhu, Zhichao; Zhu, Jingtao; Gu, Mu; Chen, Hong; Liu, Jinliang; Chen, Liang; Ouyang, Xiaoping

2018-04-30

Plastic scintillators are widely used in various radiation measurement systems. However, detection efficiency and signal-to-noise are limited due to the total internal reflection, especially for weak signal detection situations. In the present investigation, large-area photonic crystals consisting of an array of periodic truncated cone holes were prepared based on hot embossing technology aiming at coupling with the surface of plastic scintillator to improve the light extraction efficiency and directionality control. The experimental results show that a maximum enhancement of 64% at 25° emergence angle along Γ-M orientation and a maximum enhancement of 58% at 20° emergence angle along Γ-K orientation were obtained. The proposed fabrication method of photonic crystal scintillator can avoid complicated pattern transfer processes used in most traditional methods, leading to a simple, economical method for large-area preparation. The photonic crystal scintillator demonstrated in this work is of great value for practical applications of nuclear radiation detection.

ODIN-object-oriented development interface for NMR.

PubMed

Jochimsen, Thies H; von Mengershausen, Michael

2004-09-01

A cross-platform development environment for nuclear magnetic resonance (NMR) experiments is presented. It allows rapid prototyping of new pulse sequences and provides a common programming interface for different system types. With this object-oriented interface implemented in C++, the programmer is capable of writing applications to control an experiment that can be executed on different measurement devices, even from different manufacturers, without the need to modify the source code. Due to the clear design of the software, new pulse sequences can be created, tested, and executed within a short time. To post-process the acquired data, an interface to well-known numerical libraries is part of the framework. This allows a transparent integration of the data processing instructions into the measurement module. The software focuses mainly on NMR imaging, but can also be used with limitations for spectroscopic experiments. To demonstrate the capabilities of the framework, results of the same experiment, carried out on two NMR imaging systems from different manufacturers are shown and compared with the results of a simulation.

Differentiating Amino Acid Residues and Side Chain Orientations in Peptides Using Scanning Tunneling Microscopy

PubMed Central

Claridge, Shelley A.; Thomas, John C.; Silverman, Miles A.; Schwartz, Jeffrey J.; Yang, Yanlian; Wang, Chen; Weiss, Paul S.

2014-01-01

Single-molecule measurements of complex biological structures such as proteins are an attractive route for determining structures of the large number of important biomolecules that have proved refractory to analysis through standard techniques such as X-ray crystallography and nuclear magnetic resonance. We use a custom-built low-current scanning tunneling microscope to image peptide structure at the single-molecule scale in a model peptide that forms β sheets, a structural motif common in protein misfolding diseases. We successfully differentiate between histidine and alanine amino acid residues, and further differentiate side chain orientations in individual histidine residues, by correlating features in scanning tunneling microscope images with those in energy-optimized models. Beta sheets containing histidine residues are used as a model system due to the role histidine plays in transition metal binding associated with amyloid oligomerization in Alzheimer’s and other diseases. Such measurements are a first step toward analyzing peptide and protein structures at the single-molecule level. PMID:24219245

Top-down contingent feature-specific orienting with and without awareness of the visual input.

PubMed

Ansorge, Ulrich; Horstmann, Gernot; Scharlau, Ingrid

2011-01-01

In the present article, the role of endogenous feature-specific orienting for conscious and unconscious vision is reviewed. We start with an overview of orienting. We proceed with a review of masking research, and the definition of the criteria of experimental protocols that demonstrate endogenous and exogenous orienting, respectively. Against this background of criteria, we assess studies of unconscious orienting and come to the conclusion that so far studies of unconscious orienting demonstrated endogenous feature-specific orienting. The review closes with a discussion of the role of unconscious orienting in action control.

Xenon NMR of liquid crystals confined to cylindrical nanocavities: a simulation study.

PubMed

Karjalainen, Jouni; Vaara, Juha; Straka, Michal; Lantto, Perttu

2015-03-21

Applications of liquid crystals (LCs), such as smart windows and the ubiquitous display devices, are based on controlling the orientational and translational order in a small volume of LC medium. Hence, understanding the effects of confinement to the liquid crystal phase behaviour is essential. The NMR shielding of (129)Xe atoms dissolved in LCs constitutes a very sensitive probe to the details of LC environment. Linking the experimental results to microscopic phenomena calls for molecular simulations. In this work, the NMR shielding of atomic (129)Xe dissolved in a uniaxial thermotropic LC confined to nanosized cylindrical cavities is computed from coarse-grained (CG) isobaric Monte Carlo (MC) simulations with a quantum-chemically (QC) pre-parameterised pairwise-additive model for the Xe nuclear shielding tensor. We report the results for the (129)Xe nuclear shielding and its connection to the structure and order of the LC appropriate to two different cavity sizes, as well as a comparison to the results of bulk (non-confined) simulations. We find that the confinement changes the LC phase structure dramatically and gives rise to the coexistence of varying degrees of LC order, which is reflected in the Xe shielding. Furthermore, we qualitatively reproduce the behaviour of the mean (129)Xe chemical shift with respect to temperature for atomic Xe dissolved in LC confined to controlled-pore glass materials. In the small-radius cavity the nematic - paranematic phase transition is revealed only by the anisotropic component of the (129)Xe nuclear shielding. In the larger cavity, the nematic - paranematic - isotropic transition is clearly seen in the Xe shielding. The simulated (129)Xe NMR shielding is insensitive to the smectic-A - nematic transition, since in the smectic-A phase, the Xe atoms largely occupy the imperfect layer structure near the cavity walls. The direct contribution of the cavity wall to (129)Xe nuclear shielding is dependent on the cavity size but independent of temperature. Our results show that the combination of CG simulations and a QC pre-parameterised (129)Xe NMR shielding allows efficient studies of the phase behaviour and structure of complex systems containing thousands of molecules, and brings us closer to the simulation of NMR experiments.

Regular oscillatory behavior of aqueous solutions of CuII salts related to effects on equilibrium dynamics of ortho/para hydrogen spin isomers of water.

PubMed

Morré, D J; Orczyk, J; Hignite, H; Kim, C

2008-02-01

Cell surface and growth-related NADH oxidases with protein disulfide-thiol interchange activity, ECTO-NOX, exhibit copper-dependent, clock-related, temperature-independent and entrainable patterns of regular oscillations in the rate of oxidation of NAD(P)H as do aqueous solutions of copper salts. Because of time scale similarities, a basis for the oscillatory patterns in nuclear spin orientations of the hydrogen atoms of the copper-associated water was sought. Extended X-ray absorption fine structure (EXAFS) measurements at 9302 eV on pure water were periodic with a ca. 3.5 min peak to peak separation. Decomposition fits revealed 5 unequally spaced maxima similar to those observed previously for Cu(II)Cl(2) to generate a period length of about 18 min. With D(2)O, the period length was proportionately increased by 30% to 24 min. The redox potential of water and of D(2)O also oscillated with 18 and 24 min period lengths, respectively. Measurements in the middle infrared spectral region above a water sample surface revealed apparent oscillations in the two alternative orientations of the nuclear spins (ortho and para) of the hydrogen atoms of the water or D(2)O with 5 unequally spaced maxima and respective period lengths of 18 and 24 min. Thus, the time keeping oscillations of ECTO-NOX proteins appear to reflect the equilibrium dynamics of ortho-para hydrogen atom spin ratios of water where the presence of metal cations such as Cu(II) in solution determine period length.

Mental-orientation: A new approach to assessing patients across the Alzheimer's disease spectrum.

PubMed

Peters-Founshtein, Gregory; Peer, Michael; Rein, Yanai; Kahana Merhavi, Shlomzion; Meiner, Zeev; Arzy, Shahar

2018-05-21

This study aims to assess the role of mental-orientation in the diagnosis of mild cognitive impairment and Alzheimer's disease using a novel task. A behavioral study (Experiment 1) compared the mental-orientation task to standard neuropsychological tests in patients across the Alzheimer's disease spectrum. A functional MRI study (Experiment 2) in young adults compared activations evoked by the mental-orientation and standard-orientation tasks as well as their overlap with brain regions susceptible to Alzheimer's disease pathology. The mental-orientation task differentiated mild cognitively impaired and healthy controls at 95% accuracy, while the Addenbrooke's Cognitive Examination, Mini-Mental State Examination and standard-orientation achieved 74%, 70% and 50% accuracy, respectively. Functional MRI revealed the mental-orientation task to preferentially recruit brain regions exhibiting early Alzheimer's-related atrophy, unlike the standard-orientation test. Mental-orientation is suggested to play a key role in Alzheimer's disease, and consequently in early detection and follow-up of patients along the Alzheimer's disease spectrum. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Toward a domain-specific approach to the study of parental psychological control: distinguishing between dependency-oriented and achievement-oriented psychological control.

PubMed

Soenens, Bart; Vansteenkiste, Maarten; Luyten, Patrick

2010-02-01

Theory and research suggest that psychologically controlling parenting can be driven by parental concerns in two different domains, that is, interpersonal closeness and achievement. Three studies addressing this hypothesis are presented. Study 1 provides evidence for the validity of the Dependency-Oriented and Achievement-Oriented Psychological Control Scale (DAPCS), a new measure assessing psychological control in these two domains. Study 2 showed that dependency-oriented and achievement-oriented psychological control were related in expected ways to parental separation anxiety and perfectionism in a sample of mothers and fathers. Finally, Study 3 showed that dependency-oriented and achievement-oriented psychological control were differentially related to middle adolescent dependency and self-criticism and that these personality features act as specific intervening variables between the domain-specific expressions of psychological control and depressive symptoms. It is argued that the distinction between two domain-specific expressions of psychological control may allow for a more intricate analysis of the processes involved in intrusive parenting.

Learning to Embrace Nuclear Physics through Education

NASA Astrophysics Data System (ADS)

Avadanei, Camelia

2010-01-01

Due to its achievements, nuclear physics is more and more present in life of every member of the society. Its applications in the medical field and in nuclear energy, as well as the advanced research, always pushing the limits of science towards micro cosmos and macro cosmos, are subjects frequently presented in the media. In addition to their invaluable benefits, these achievements involve also particular rules to prevent potential risks. These risks are also underlined by the media, often being presented in an unfriendly manner. Specialists in nuclear physics are familiar with these problems complying with the specific rules in order to reduce risks at insignificant levels. The development of a specific field ("Radiation protection") defining norms and requirements for "assuring the radiological safety of the workers, population and environment," and its dynamics represent a proof of a responsible attitude regarding nuclear safety. Dedicated international bodies and experts analyze and rigorously evaluate risks in order to draw the right ways of managing activity in the field. The improvement of the formal and informal education of public regarding the real risks of nuclear applications is very important in order to understand and better assimilate some general rules concerning the use of these techniques, as well as for their correct perception, leading to an increase of interest towards nuclear physics. This educational update can be started even from elementary school and continued in each stage of formal education in adapted forms. The task of informing general public is to be carried out mainly by specialists who, unlike 30-40 years ago, can rely on a much more efficient generation of communications' mean. Taking into account the lack of interest for nuclear, an attractive way of presenting the achievements and future possibilities of nuclear physics would contribute to youth orientation towards specific universities in order to become next generation of specialists in the field. Facing new challenges, society becomes aware of the fact that education represents the real solution to escalade them. Nuclear physics plays an important role in ensuring energetic resources for the near future and in reducing greenhouse effects. On the other hand, especially nuclear physics will permit to solve the enigma of universe birth. As in any other field, development involves continuous education and knowledge upgrading for all categories carrying out nuclear activities. For radiation protection workers and specialists, periodically refreshment courses are mandatory, in compliance with the national and international specific requirements.

Nuclear Time Delay Effects on K-Vacancy Production in Deep-Inelastic U+U Collisions

NASA Astrophysics Data System (ADS)

Molitoris, John David

1987-09-01

Atomic K-vacancy production in 7.5-MeV/u U+U collisons has been studied for small-impact-parameter (b) elastic scattering and for deep-inelastic nuclear reactions, by measuring coincidences between U x-rays and scattered U particles. The K-vacancy production probability (P(,K)(b)) in elastic U+U collisions was measured as a function of b and it is shown that P(,K) follows a scaling law from b = 10 to 85 fm. Below 10 fm, P(,K)(b) increases sharply from 0.91 (+OR-) 0.08 at 11.6 fm to a maximum of 1.8 (+OR -) 0.18 vacancies per collison at 7 fm. This behavior at small b could be due to rotational coupling of the 2p(,3/2)(pi), 2p(,3/2)(sigma) (--->) 2p(,1/2)(sigma) molecular orbitals, but present theoretical calculations do not reflect this. Since internal conversion is a major background in these measurements, it was necessary to observe how the internal conversion changes in elastic collisions as b (--->) 0, so that the internal conversion for atomic collisons accompanied by nuclear reactions could be understood. Nuclear-reaction effects of P(,K)(b (DBLTURN) 0) were studied as a function of the total kinetic energy loss (TKEL) of the nuclear interaction for 2-body break -up (U + U (--->) U' + U'') and 3-body break-up (U + U ( --->) U' + 2ff). In 4-body break-up (U + U (--->) 2ff' + 2ff''), P(,K) was measured over all TKEL. In 2-body break-up a 78% reduction of P(,K) is observed between TKEL = 0 and 275 MeV. This trend matches a theoretical decrease in P(,K)(T(,D)), where T(,D) in the nuclear interaction time or delay time. A parametric relation between TKEL and T(,D) can be formed between the theoretical calculation and the experimental result. A delay time of (0.52 (+OR -) 0.17) x 10('-21) sec at TKEL = 100 MeV is deter- mined. There is overall agreement between this atomic physics result and nuclear diffusion model calculations. The measured P(,K)(TKEL) for 3-body break-up is nearly identical to that of 2-body break-up. This indicates that there is a large compo- nent of fissioning nuclei ((TURN)50%) whose fission time (T(,f)) can not be much smaller than the U K-vacancy decay time (T(,K)(U) (DBLTURN) 10('-18) sec). The overall P(,K)('3-body) results and a study of distinct spatial orientations of the fission fragments in relation to the surviving U-like partner show a reduction in P(,K)('3-body) for TKEL >(, )175 MeV. This could imply that T(,f) (LESSTHEQ) 10('-18) sec for TKEL >(, )175 MeV. Measurement of the net U K x-ray yield over all TKEL in 4-body break-up reveals that P(,K)('4-body) = 0.36 (+OR-) 0.08. When compared to similar net probabilities for 2- and 3-body break-up, this indicates that about 50% of the U-like reaction partners which ultimately fission live at least 10('-18) sec. This result is in overall agreement with the 3-body results, but exceeds usual nuclear physics estimates of T(,f) (TURN) 10('-20) sec. However, crystal blocking techniques have observed long lived fission components (T(,f) (GREATERTHEQ) 10('-18) sec) in some nuclear reactions.

Brittle Creep of Tournemire Shale: Orientation, Temperature and Pressure Dependences

NASA Astrophysics Data System (ADS)

Geng, Zhi; Bonnelye, Audrey; Dick, Pierre; David, Christian; Chen, Mian; Schubnel, Alexandre

2017-04-01

Time and temperature dependent rock deformation has both scientific and socio-economic implications for natural hazards, the oil and gas industry and nuclear waste disposal. During the past decades, most studies on brittle creep have focused on igneous rocks and porous sedimentary rocks. To our knowledge, only few studies have been carried out on the brittle creep behavior of shale. Here, we conducted a series of creep experiments on shale specimens coming from the French Institute for Nuclear Safety (IRSN) underground research laboratory located in Tournemire, France. Conventional tri-axial experiments were carried under two different temperatures (26˚ C, 75˚ C) and confining pressures (10 MPa, 80 MPa), for three orientations (σ1 along, perpendicular and 45˚ to bedding). Following the methodology developed by Heap et al. [2008], differential stress was first increased to ˜ 60% of the short term peak strength (10-7/s, Bonnelye et al. 2016), and then in steps of 5 to 10 MPa every 24 hours until brittle failure was achieved. In these long-term experiments (approximately 10 days), stress and strains were recorded continuously, while ultrasonic acoustic velocities were recorded every 1˜15 minutes, enabling us to monitor the evolution of elastic wave speed anisotropy. Temporal evolution of anisotropy was illustrated by inverting acoustic velocities to Thomsen parameters. Finally, samples were investigated post-mortem using scanning electron microscopy. Our results seem to contradict our traditional understanding of loading rate dependent brittle failure. Indeed, the brittle creep failure stress of our Tournemire shale samples was systematically observed ˜50% higher than its short-term peak strength, with larger final axial strain accumulated. At higher temperatures, the creep failure strength of our samples was slightly reduced and deformation was characterized with faster 'steady-state' creep axial strain rates at each steps, and larger final axial strain accumulated. At each creep step, ultrasonic wave velocities first decreased, and then increased gradually. The magnitude of elastic wave velocity variations showed an important orientation and temperature dependence. Velocities measured perpendicular to bedding showed increased variation, variation that was enhanced at higher temperature and higher pressure. The case of complete elastic anisotropy reversal was even observed for sample deformed perpendicular to bedding, with a reduction amount of axial strain needed to reach anisotropy reversal at higher temperature. Our data were indicative of competition between crack growth, sealing/healing, and possibly mineral rotation or anisotropic compaction during creep. SEM investigation confirmed evidence of time dependent pressure solution and crack sealing/healing. Our research not only has practical engineering consequence but, more importantly, can provide valuable insights into the underlying mechanisms of creep in complex media like shale. In particular, our study highlights that the short-term peak strength has little meaning in shale material, which can over-consolidate importantly by 'plastic' flow. In addition, we showed that elastic anisotropy can switch and even reverse over relatively short time periods (<10 days) and for relatively small amount of plastic deformation (<5%).

Visual Search for Object Orientation Can Be Modulated by Canonical Orientation

ERIC Educational Resources Information Center

Ballaz, Cecile; Boutsen, Luc; Peyrin, Carole; Humphreys, Glyn W.; Marendaz, Christian

2005-01-01

The authors studied the influence of canonical orientation on visual search for object orientation. Displays consisted of pictures of animals whose axis of elongation was either vertical or tilted in their canonical orientation. Target orientation could be either congruent or incongruent with the object's canonical orientation. In Experiment 1,…

Goal orientations of health profession students throughout the undergraduate program: a multilevel study.

PubMed

Kool, Ada; Mainhard, Tim; Brekelmans, Mieke; van Beukelen, Peter; Jaarsma, Debbie

2016-03-31

The achievement goal theory defines two major foci of students' learning goals (1) primarily interested in truly mastering a task (mastery orientation), and (2) striving to show ones competences to others (performance orientation). The present study is undertaken to better understand if and how health profession students' goal orientations change during the undergraduate program and to what degree gender, academic achievement, and self-efficacy are associated with mastery and performance orientation between students and within students over time. By means of an online questionnaire, students of medical, pharmaceutical, and veterinary sciences (N = 2402) were asked to rate themselves on mastery orientation, performance orientation, and self-efficacy at the beginning of five consecutive semesters. Data on grades and gender were drawn from university's files. Multilevel analyses were used for data analysis. Students' goal orientations showed relative stability over time, but substantial fluctuations within individual students were found. These fluctuations were associated with fluctuations in self-efficacy. Students' gender, high school grades, study grades, and self-efficacy were all associated with differences in mastery or performance orientation between students. Self-efficacy was the strongest predictor for mastery orientation and grades for performance orientation. The relatively strong association between the goal orientations and students' self-efficacy found in this study emphasizes the potential of enhancing self-efficacy in health profession students. Also, for educators and researchers, fluctuations of both goal orientations within individual students are important to consider.

Future orientation, school contexts, and problem behaviors: a multilevel study.

PubMed

Chen, Pan; Vazsonyi, Alexander T

2013-01-01

The association between future orientation and problem behaviors has received extensive empirical attention; however, previous work has not considered school contextual influences on this link. Using a sample of N = 9,163 9th to 12th graders (51.0 % females) from N = 85 high schools of the National Longitudinal Study of Adolescent Health, the present study examined the independent and interactive effects of adolescent future orientation and school contexts (school size, school location, school SES, school future orientation climate) on problem behaviors. Results provided evidence that adolescent future orientation was associated independently and negatively with problem behaviors. In addition, adolescents from large-size schools reported higher levels of problem behaviors than their age mates from small-size schools, controlling for individual-level covariates. Furthermore, an interaction effect between adolescent future orientation and school future orientation climate was found, suggesting influences of school future orientation climate on the link between adolescent future orientation and problem behaviors as well as variations in effects of school future orientation climate across different levels of adolescent future orientation. Specifically, the negative association between adolescent future orientation and problem behaviors was stronger at schools with a more positive climate of future orientation, whereas school future orientation climate had a significant and unexpectedly positive relationship with problem behaviors for adolescents with low levels of future orientation. Findings implicate the importance of comparing how the future orientation-problem behaviors link varies across different ecological contexts and the need to understand influences of school climate on problem behaviors in light of differences in psychological processes among adolescents.

Action versus state orientation and self-control performance after depletion.

PubMed

Gröpel, Peter; Baumeister, Roy F; Beckmann, Jürgen

2014-04-01

Three studies investigated the role of action versus state orientation in how people deal with depletion of self-control resources. Action-oriented persons were expected to continue allocating resources and hence to perform better than state-oriented persons who were expected to conserve strength. Consistent with this, action-oriented persons performed better on the d2 test of attention than state-oriented persons after a strenuous physical exercise (Study 1), showed higher acuity on the critical fusion frequency test after a test of vigilance (Study 2), and performed better on the Stroop test after a depleting sensorimotor task (Study 3). No differences emerged between action- and state-oriented persons in their initial performance and in a non-depleting context. The impact of depletion on subsequent performance is thus not fixed, but moderated by personality.

Complete genome sequence and integrated protein localization and interaction map for alfalfa dwarf virus, which combines properties of both cytoplasmic and nuclear plant rhabdoviruses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bejerman, Nicolás, E-mail: n.bejerman@uq.edu.au; Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072; Giolitti, Fabián

Summary: We have determined the full-length 14,491-nucleotide genome sequence of a new plant rhabdovirus, alfalfa dwarf virus (ADV). Seven open reading frames (ORFs) were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, in the order 3′-N-P-P3-M-G-P6-L-5′. The ORFs are separated by conserved intergenic regions and the genome coding region is flanked by complementary 3′ leader and 5′ trailer sequences. Phylogenetic analysis of the nucleoprotein amino acid sequence indicated that this alfalfa-infecting rhabdovirus is related to viruses in the genus Cytorhabdovirus. When transiently expressed as GFP fusions in Nicotiana benthamiana leaves, most ADV proteins accumulated in the cellmore » periphery, but unexpectedly P protein was localized exclusively in the nucleus. ADV P protein was shown to have a homotypic, and heterotypic nuclear interactions with N, P3 and M proteins by bimolecular fluorescence complementation. ADV appears unique in that it combines properties of both cytoplasmic and nuclear plant rhabdoviruses. - Highlights: • The complete genome of alfalfa dwarf virus is obtained. • An integrated localization and interaction map for ADV is determined. • ADV has a genome sequence similarity and evolutionary links with cytorhabdoviruses. • ADV protein localization and interaction data show an association with the nucleus. • ADV combines properties of both cytoplasmic and nuclear plant rhabdoviruses.« less

Picking up the shield: Incorporating defense into strategic nuclear doctrine. Research report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruotsala, M.G.

Picking up the Shield is an interesting and enlightening account of the evolution of strategic nuclear doctrine. It puts the offense-defense relationship into a historical perspective that lends important insight into the ongoing debate over strategic defenses. Although this debate centers on the active defenses contemplated by the strategic defense initiative, Lt Col Michael G. Ruotsala makes the point that passive defenses are also an important component of strategic defense. He sees the inherent passive defenses of the Triad as being a key to maintaining offense-oriented deterrence, and he makes a good case for survivable Peacekeeper basing and a smallmore » mobile intercontinental ballistic missile (ICBM) to enhance deterrence and pave the way for active defense. Although the future may hold a strategic defense with new, even revolutionary, weapons, any future program will embody old concepts of offense and defense. For the foreseeable future, offensive strategic forces will continue to play a dominant role in US defense policy. However, strategic defenses are consistent with US strategic doctrine. More important for deterrence, defenses are consistent with Soviet doctrine. Clearly, complementing roles for both the offense and defense are critical for developing a doctrine that enhances deterrence of a nuclear exchange between the United States and the Soviet Union. It is also clear that Picking up the Shield makes a significant contribution to understanding the challenge we face as we incorporate defense into strategic nuclear doctrine.« less

Pessimistic orientation in relation to telomere length in older men: the VA Normative Aging Study

PubMed Central

Ikeda, Ai; Schwartz, Joel; Peters, Junenette L.; Baccarelli, Andrea A.; Hoxha, Mirjam; Dioni, Laura; Spiro, Avron; Sparrow, David; Vokonas, Pantel; Kubzansky, Laura D.

2014-01-01

Background Recent research suggests pessimistic orientation is associated with shorter leukocyte telomere length (LTL). However, this is the first study to look not only at effects of pessimistic orientation on average LTL at multiple time points, but also at effects on the rate of change in LTL over time. Methods Participants were older men from the VA Normative Aging Study (n=490). The Life Orientation Test (LOT) was used to measure optimistic and pessimistic orientations at study baseline, and relative LTL by telomere to single copy gene ratio (T:S ratio) was obtained repeatedly over the course of the study (1999-2008). A total of 1,010 observations were included in the analysis. Linear mixed effect models with a random subject intercept were used to estimate associations. Results Higher pessimistic orientation scores were associated with shorter average LTL (percent difference by 1-SD increase in pessimistic orientation (95% CI): -3.08 (-5.62, -0.46)), and the finding was maintained after adjusting for the higher likelihood that healthier individuals return for follow-up visits (-3.44 (-5.95,-0.86)). However, pessimistic orientation scores were not associated with rate of change in LTL over time. No associations were found between overall optimism and optimistic orientation subscale scores and LTL. Conclusion Higher pessimistic orientation scores were associated with shorter LTL in older men. While there was no evidence that pessimistic orientation was associated with rate of change in LTL over time, higher levels of pessimistic orientation were associated with shorter LTL at baseline and this association persisted over time. PMID:24636503

The biphasic interphase-mitotic polarity of cell nuclei induced under DNA replication stress seems to be correlated with Pin2 localization in root meristems of Allium cepa.

PubMed

Żabka, Aneta; Trzaskoma, Paweł; Winnicki, Konrad; Polit, Justyna Teresa; Chmielnicka, Agnieszka; Maszewski, Janusz

2015-02-01

Long-term treatment of Allium cepa seedlings with low concentration of hydroxyurea (HU) results in a disruption of cell cycle checkpoints, leading root apex meristem (RAM) cells to an abnormal organization of nuclear structures forming interphase (I) and mitotic (M) domains of chromatin at opposite poles of the nucleus. Thus far, both critical cell length and an uneven distribution of cyclin B-like proteins along the nuclear axis have been recognized as essential factors needed to facilitate the formation of biphasic interphase-mitotic (IM) cells. Two new aspects with respect to their emergence are investigated in this study. The first concerns a relationship between the polarity of increasing chromatin condensation (IM orientation) and the acropetal (base→apex) alignment of RAM cell files. The second problem involves the effects of auxin (IAA), on the frequency of IM cells. We provide evidence that there is an association between the advanced M-poles of the IM cell nuclei and the polarized accumulation sites of auxin efflux carriers (PIN2 proteins) and IAA. Furthermore, our observations reveal exclusion regions for PIN2 proteins in the microtubule-rich structures, such as preprophase bands (PPBs) and phragmoplast. The current and previous studies have prompted us to formulate a hypothetical mechanism linking PIN2-mediated unilateral localization of IAA and the induction of bipolar IM cells in HU-treated RAMs of A. cepa. Copyright © 2014 Elsevier GmbH. All rights reserved.

Development of an object-oriented ORIGEN for advanced nuclear fuel modeling applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skutnik, S.; Havloej, F.; Lago, D.

2013-07-01

The ORIGEN package serves as the core depletion and decay calculation module within the SCALE code system. A recent major re-factor to the ORIGEN code architecture as part of an overall modernization of the SCALE code system has both greatly enhanced its maintainability as well as afforded several new capabilities useful for incorporating depletion analysis into other code frameworks. This paper will present an overview of the improved ORIGEN code architecture (including the methods and data structures introduced) as well as current and potential future applications utilizing the new ORIGEN framework. (authors)

Communication path for extreme environments

NASA Technical Reports Server (NTRS)

Jorgensen, Charles C. (Inventor); Betts, Bradley J. (Inventor)

2010-01-01

Methods and systems for using one or more radio frequency identification devices (RFIDs), or other suitable signal transmitters and/or receivers, to provide a sensor information communication path, to provide location and/or spatial orientation information for an emergency service worker (ESW), to provide an ESW escape route, to indicate a direction from an ESW to an ES appliance, to provide updated information on a region or structure that presents an extreme environment (fire, hazardous fluid leak, underwater, nuclear, etc.) in which an ESW works, and to provide accumulated thermal load or thermal breakdown information on one or more locations in the region.

An exploratory study of the categorical versus spectrum nature of sexual orientation.

PubMed

Savin-Williams, Ritch C

2014-01-01

This exploratory study investigated the nature of sexual orientation (categorical or spectrum) by assessing the relative ability of sexual and romantic indicators to be predicted by sexual orientation labels. Young adults from a variety of community and college venues (N =292) reported their sexual orientation label on a 9-point scale; from a 10-item list, their sexual identity; and the percentage of their sexual attraction, fantasy, genital contact, infatuation, and romantic relationship directed to males and females. Although the five indicators were significantly intercorrelated and sexual orientation labels predicted each indicator, discrepancies existed across indicators in relationship to sexual orientation (highest for attraction, lowest for romantic relationship). Sexual identity and sexual orientation label were strongly related at the ends of the sexual spectrum, less so in the middle. Men were nearly as nonexclusive as women. Study results supported the perspective that sexual orientation is a continuously distributed individual characteristic.

Path-integral simulation of solids.

PubMed

Herrero, C P; Ramírez, R

2014-06-11

The path-integral formulation of the statistical mechanics of quantum many-body systems is described, with the purpose of introducing practical techniques for the simulation of solids. Monte Carlo and molecular dynamics methods for distinguishable quantum particles are presented, with particular attention to the isothermal-isobaric ensemble. Applications of these computational techniques to different types of solids are reviewed, including noble-gas solids (helium and heavier elements), group-IV materials (diamond and elemental semiconductors), and molecular solids (with emphasis on hydrogen and ice). Structural, vibrational, and thermodynamic properties of these materials are discussed. Applications also include point defects in solids (structure and diffusion), as well as nuclear quantum effects in solid surfaces and adsorbates. Different phenomena are discussed, as solid-to-solid and orientational phase transitions, rates of quantum processes, classical-to-quantum crossover, and various finite-temperature anharmonic effects (thermal expansion, isotopic effects, electron-phonon interactions). Nuclear quantum effects are most remarkable in the presence of light atoms, so that especial emphasis is laid on solids containing hydrogen as a constituent element or as an impurity.

Assessment of MARMOT. A Mesoscale Fuel Performance Code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tonks, M. R.; Schwen, D.; Zhang, Y.

2015-04-01

MARMOT is the mesoscale fuel performance code under development as part of the US DOE Nuclear Energy Advanced Modeling and Simulation Program. In this report, we provide a high level summary of MARMOT, its capabilities, and its current state of validation. The purpose of MARMOT is to predict the coevolution of microstructure and material properties of nuclear fuel and cladding. It accomplished this using the phase field method coupled to solid mechanics and heat conduction. MARMOT is based on the Multiphysics Object-Oriented Simulation Environment (MOOSE), and much of its basic capability in the areas of the phase field method, mechanics,more » and heat conduction come directly from MOOSE modules. However, additional capability specific to fuel and cladding is available in MARMOT. While some validation of MARMOT has been completed in the areas of fission gas behavior and grain growth, much more validation needs to be conducted. However, new mesoscale data needs to be obtained in order to complete this validation.« less

Synthesis, stereochemical, structural, and biological studies of a series of N‧-(2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-ylidene)pyrazine-2-carbohydrazides

NASA Astrophysics Data System (ADS)

Mangalam, M.; Sebastian Antony Selvan, C.; Sankar, C.

2017-02-01

A new series of N‧-(2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-ylidene)pyrazine-2-carbohydrazides (8-14) were synthesized by the corresponding 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-ones (1-7) reaction with pyrazine-2-carbohydrazide. The stereochemistry of the newly synthesized compounds were unambiguously assigned using FT-IR, 1H, 13C, and 2D (COSY, HSQC, HMBC, ROESY) nuclear magnetic resonance (NMR) spectral data. The chemical shifts suggest that all these compounds adopt twin-chair conformation with equatorial orientation of aryl substitutions in solution. Hydrazones were screened for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv and antibacterial activity against a set of pathogenic bacteria. Most of the halogenated compounds showed promising antitubercular and antibacterial activities.

Intercalation complex of proflavine with DNA: Structure and dynamics by solid-state NMR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang, Pei; Juang, Chilong; Harbison, G.S.

1990-07-06

The structure of the complex formed between the intercalating agent proflavine and fibrous native DNA was studied by one- and two-dimensional high-resolution solid-state nuclear magnetic resonance (NMR). Carbon-13-labeled proflavine was used to show that the drug is stacked with the aromatic ring plane perpendicular to the fiber axis and that it is essentially immobile. Natural abundance carbon-13 NMR of the DNA itself shows that proflavine binding does not change the puckering of the deoxyribose ring. However, phosphorus-31 NMR spectra show profound changes in the orientation of the phosphodiester grouping on proflavine binding, with some of the phosphodiesters tilting almost parallelmore » to the helix axis, and a second set almost perpendicular. The first group to the phosphodiesters probably spans the intercalation sites, whereas the tilting of the second set likely compensates for the unwinding of the DNA by the intercalator.« less

Fusion-fission Study at JAEA for Heavy-element Synthesis

NASA Astrophysics Data System (ADS)

Nishio, K.

Fission fragment mass distributions were measured in the heavy-ion induced fission using 238U target nucleus. The mass distribu- tions changed drastically with incident energy. The results are explained by a change of the ratio between fusion and qasifission with nuclear orientation. A calculation based on a fluctuation dissipation model reproduced the mass distributions and their inci- dent energy dependence. Fusion probability was determined in the analysis. Evaporation residue cross sections were calculated with a statistical model in the reactions of 30Si+238U and 34S+238U using the obtained fusion probability in the entrance channel. The results agree with the measured cross sections of 263,264Sg and 267,268Hs, produced by 30Si+238U and 34S+238U, respectively. It is also suggested that the sub-barrier energies can be used for heavy element synthesis.

In-beam fissio study at JAEA for heavy element synthesis

NASA Astrophysics Data System (ADS)

Nishio, K.; Ikezoe, H.; Hofmann, S.; Ackermann, D.; Aritomo, Y.; Comas, V. F.; Düllmann, Ch. E.; Heinz, S.; Heredia, J. A.; Heßberger, F. P.; Hirose, K.; Khuyagbaatar, J.; Kindler, B.; Kojouharov, I.; Lommel, B.; Makii, M.; Mann, R.; Mitsuoka, S.; Nishinaka, I.; Ohtsuki, T.; Saro, S.; Schädel, M.; Popeko, A. G.; Türler, A.; Wakabayashi, Y.; Watanabe, Y.; Yakushev, A.; Yeremin, A.

2013-04-01

Fission fragment mass distributions were measured in the heavy-ion induced fission using 238U target nucleus. The mass distributions changed drastically with incident energy. The results are explained by a change of the ratio between fusion and qasifission with nuclear orientation. A calculation based on a fluctuation dissipation model reproduced the mass distributions and their incident energy dependence. Fusion probability was determined in the analysis. Evaporation residue cross sections were calculated with a statistical model in the reactions of 30Si+238U and 34S+238U using the obtained fusion probability in the entrance channel. The results agree with the measured cross sections of 263,264Sg and 267,268Hs, produced by 30Si+238U and 34S+238U, respectively. It is also suggested that the sub-barrier energies can be used for heavy element synthesis.

Measurements of the electric form factor of the neutron up to Q2=3.4 GeV2 using the reaction 3He(e,e'n)pp.

PubMed

Riordan, S; Abrahamyan, S; Craver, B; Kelleher, A; Kolarkar, A; Miller, J; Cates, G D; Liyanage, N; Wojtsekhowski, B; Acha, A; Allada, K; Anderson, B; Aniol, K A; Annand, J R M; Arrington, J; Averett, T; Beck, A; Bellis, M; Boeglin, W; Breuer, H; Calarco, J R; Camsonne, A; Chen, J P; Chudakov, E; Coman, L; Crowe, B; Cusanno, F; Day, D; Degtyarenko, P; Dolph, P A M; Dutta, C; Ferdi, C; Fernández-Ramírez, C; Feuerbach, R; Fraile, L M; Franklin, G; Frullani, S; Fuchs, S; Garibaldi, F; Gevorgyan, N; Gilman, R; Glamazdin, A; Gomez, J; Grimm, K; Hansen, J-O; Herraiz, J L; Higinbotham, D W; Holmes, R; Holmstrom, T; Howell, D; de Jager, C W; Jiang, X; Jones, M K; Katich, J; Kaufman, L J; Khandaker, M; Kelly, J J; Kiselev, D; Korsch, W; LeRose, J; Lindgren, R; Markowitz, P; Margaziotis, D J; Beck, S May-Tal; Mayilyan, S; McCormick, K; Meziani, Z-E; Michaels, R; Moffit, B; Nanda, S; Nelyubin, V; Ngo, T; Nikolenko, D M; Norum, B; Pentchev, L; Perdrisat, C F; Piasetzky, E; Pomatsalyuk, R; Protopopescu, D; Puckett, A J R; Punjabi, V A; Qian, X; Qiang, Y; Quinn, B; Rachek, I; Ransome, R D; Reimer, P E; Reitz, B; Roche, J; Ron, G; Rondon, O; Rosner, G; Saha, A; Sargsian, M M; Sawatzky, B; Segal, J; Shabestari, M; Shahinyan, A; Shestakov, Yu; Singh, J; Sirca, S; Souder, P; Stepanyan, S; Stibunov, V; Sulkosky, V; Tajima, S; Tobias, W A; Udias, J M; Urciuoli, G M; Vlahovic, B; Voskanyan, H; Wang, K; Wesselmann, F R; Vignote, J R; Wood, S A; Wright, J; Yao, H; Zhu, X

2010-12-31

The electric form factor of the neutron was determined from studies of the reaction 3He(e,e'n)pp in quasielastic kinematics in Hall A at Jefferson Lab. Longitudinally polarized electrons were scattered off a polarized target in which the nuclear polarization was oriented perpendicular to the momentum transfer. The scattered electrons were detected in a magnetic spectrometer in coincidence with neutrons that were registered in a large-solid-angle detector. More than doubling the Q2 range over which it is known, we find G(E)(n)=0.0236±0.0017(stat)±0.0026(syst), 0.0208±0.0024±0.0019, and 0.0147±0.0020±0.0014 for Q(2)=1.72, 2.48, and 3.41 GeV2, respectively.

The nature of the MDI/wood bond

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marcinko, J.J.; Phanopoulos, C.; Newman, W.H.

1995-12-01

Polymeric diphenylmethane diisocyanate (pMDI) binders have been used in the wood composite industry for 20 years. Almost one half of the oriented strand board (OSB) manufactures in North America are taking advantage of its processing speed and superior board performance. MDI`s current use in Strandboard, MDF (medium density fiber board), LVL (laminated veneer lumber), Plywood, and Particleboard is wide spread. A fundamental understanding of the role of MIDI as a binder in these complex composites is essential for further processing optimization. Experimental data is presented which investigates the nature of the chemical bonding in wood composites. Solid state nuclear magneticmore » resonance (NMR) data is combined with data from thermal analysis and fluorescence microscopy to investigate the chemistry, penetration, and morphology of the isocyanate/wood interphase. Structure property relationships are developed and related to composite performance. The study contrasts isocyanate and phenol formaldehyde binder systems.« less

Measurements of the Electric Form Factor of the Neutron up to Q2 = 3.4 GeV2 using the Reaction He-3(e,e'n)pp

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riordan, Seamus; Craver, Brandon; Kelleher, Aidan

The electric form factor of the neutron was determined from studies of the reaction \\rea{} in quasi-elastic kinematics in Hall A at Jefferson Lab. Longitudinally polarized electrons were scattered off a polarized target in which the nuclear polarization was oriented perpendicular to the momentum transfer. The scattered electrons were detected in a magnetic spectrometer in coincidence with neutrons that were registered in a large-solid-angle detector. More than doubling themore » $Q^2$$-range over which it is known, we find \\GEn{}$$ = 0.0225 \\pm 0.0017 (stat) \\pm 0.0024 (syst)$, $$0.0200 \\pm 0.0023 \\pm 0.0018$$, and $$0.0142 \\pm 0.0019 \\pm 0.0013$$ for $Q^2$ = 1.72, 2.48, and 3.41~\\gevsq, respectively.« less

Implicit and explicit measures of sexual orientation attitudes: in group preferences and related behaviors and beliefs among gay and straight men.

PubMed

Jellison, William A; McConnell, Allen R; Gabriel, Shira

2004-05-01

The relations among implicit and explicit measures of sexual orientation attitudes and sexual-orientation-related behavior and beliefs among gay men (Study 1) and straight men (Studies 1 and 2) were explored. Study 1 found relations between implicit and explicit measures of sexual orientation attitudes, large differences between gay and straight men on both implicit and explicit measures, and that these measures predicted sexual-orientation-related behaviors among gay men. Also, only straight men exhibited a negative relation between their attitudes toward homosexuality and heterosexuality. Study 2 found that as straight men held more negative attitudes toward homosexuality, they more strongly endorsed the importance of heterosexual identity and of traditional masculine gender roles. These endorsements mediated the negative relation between their attitudes toward heterosexuality and homosexuality. Implications for assessing attitudes toward sexual orientation and their relations for sexual orientation identity are discussed.

An Empirical Study on the Effect of Work/Life Commitment to Work-Life Conflict

NASA Astrophysics Data System (ADS)

Ma, Li; Yin, Jie-lin

This study examined the relation between work and life orientation and work interfere with personal life or personal life interfere with work of employees in China. Cluster analysis results showed that there are four profiles of orientation: work orientation, life orientation, integration and disengagement orientation. There are significant differences in work interfere personal life and personal life interfere work between different profiles.

The measurement of threat orientations.

PubMed

Thompson, Suzanne C; Schlehofer, Michèle M; Bovin, Michelle J

2006-01-01

To develop measures of 3 threat orientations that affect responses to health behavior messages. In Study 1, college students (N = 47) completed items assessing threat orientations and health behaviors. In Study 2, college students and community adults (N = 110) completed the threat orientation items and measures of convergent and discriminant validity. In Study 1, the control-based, denial-based, and heightened-sensitivity-based threat orientation scales demonstrated good internal consistency and correlated with engagement in health behaviors. In Study 2, the convergent and discriminant validity of the 3 measures was established. The 3 scales have good internal reliability and construct validity.

Goal Orientation, Deep Learning, and Sustainable Feedback in Higher Business Education

ERIC Educational Resources Information Center

Geitz, Gerry; Brinke, Desirée Joosten-ten; Kirschner, Paul A.

2015-01-01

Relations between and changeability of goal orientation and learning behavior have been studied in several domains and contexts. To alter the adopted goal orientation into a mastery orientation and increase a concomitant deep learning in international business students, a sustainable feedback intervention study was carried out. Sustainable…

Outcomes of a College Wilderness Orientation Program

ERIC Educational Resources Information Center

Lien, Matt; Goldenberg, Marni

2012-01-01

Wilderness orientation programs have been utilized by colleges and universities in the United States for nearly 75 years. This study, using means-end theory, reveals the outcomes of a wilderness orientation program for incoming students. A retroactive study was conducted for all participants who had taken part in a wilderness orientation program…

A work observation study of nuclear medicine technologists: interruptions, resilience and implications for patient safety

PubMed Central

Larcos, George; Prgomet, Mirela; Georgiou, Andrew; Westbrook, Johanna

2017-01-01

Background Errors by nuclear medicine technologists during the preparation of radiopharmaceuticals or at other times can cause patient harm and may reflect the impact of interruptions, busy work environments and deficient systems or processes. We aimed to: (a) characterise the rate and nature of interruptions technologists experience and (b) identify strategies that support safety. Methods We performed 100 hours of observation of 11 technologists at a major public hospital and measured the proportions of time spent in eight categories of work tasks, location of task, interruption rate and type and multitasking (tasks conducted in parallel). We catalogued specific safety-oriented strategies used by technologists. Results Technologists completed 5227 tasks and experienced 569 interruptions (mean, 4.5 times per hour; 95% CI 4.1 to 4.9). The highest interruption rate occurred when technologists were in transit between rooms (10.3 per hour (95% CI 8.3 to 12.5)). Interruptions during radiopharmaceutical preparation occurred a mean of 4.4 times per hour (95% CI 3.3 to 5.6). Most (n=426) tasks were interrupted once only and all tasks were resumed after interruption. Multitasking occurred 16.6% of the time. At least some interruptions were initiated by other technologists to convey important information and/or to render assistance. Technologists employed a variety of verbal and non-verbal strategies in all work areas (notably in the hot-lab) to minimise the impact of interruptions and optimise the safe conduct of procedures. Although most were due to individual choices, some strategies reflected overt or subliminal departmental policy. Conclusions Some interruptions appear beneficial. Technologists' self-initiated strategies to support safe work practices appear to be an important element in supporting a resilient work environment in nuclear medicine. PMID:27707869

Psychology and the prevention of nuclear war

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, R.K.

This book is about our ways of thinking and about how they need to be and can be changed. It is not about the ''unparalleled catastrophe.'' By now many of us know much about that, and unless we an see clear, acceptable, and practical ways to prevent it, our minds recoil from the whole horrible subject. Therefore, the book is about the prevention of nuclear war and nothing else. At least, that is its purpose. Yet its method is primarily descriptive and analytical rather than action-oriented. It explores from different perspectives the possible causes of a world war that couldmore » be at the outset, or become, nuclear, with a special focus on the often-neglected psychological aspects of those causes. It is diagnosis more than prescription. In fact, it might be described as a many-sided effort to understand the nature and roots of the ''madness'' of our present drift toward a great war that each side is urgently-desperately-anxious to avoid. In so doing it draws on some of the insights of psychiatry (from the psychiatrists Robert Jay Lifton, John E. Mack, Jerome D. Frank, and Erich Fromm), as well as on the three disciplines that provide the chief foundation for the book: history, political science, and social psychology.« less

Spin Choreography: Basic Steps in High Resolution NMR (by Ray Freeman)

NASA Astrophysics Data System (ADS)

Minch, Michael J.

1998-02-01

There are three orientations that NMR courses may take. The traditional molecular structure course focuses on the interpretation of spectra and the use of chemical shifts, coupling constants, and nuclear Overhauser effects (NOE) to sort out subtle details of structure and stereochemistry. Courses can also focus on the fundamental quantum mechanics of observable NMR parameters and processes such a spin-spin splitting and relaxation. More recently there are courses devoted to the manipulation of nuclear spins and the basic steps of one- and two-dimensional NMR experiments. Freeman's book is directed towards the latter audience. Modern NMR methods offer a myriad ways to extract information about molecular structure and motion by observing the behavior of nuclear spins under a variety of conditions. In Freeman's words: "We can lead the spins through an intricate dance, carefully programmed in advance, to enhance, simplify, correlate, decouple, edit or assign NMR spectra." This is a carefully written, well-illustrated account of how this dance is choreographed by pulse programming, double resonance, and gradient effects. Although well written, this book is not an easy read; every word counts. It is recommended for graduate courses that emphasize the fundamentals of magnetic resonance. It is not a text on interpretation of spectra.

The Bloch equation with terms induced by an electric field

NASA Astrophysics Data System (ADS)

Garbacz, Piotr

2018-01-01

The Bloch equation of the nuclear magnetization of spin-1/2 nuclei in molecules, which have permanent electric dipole moments μe that are placed simultaneously in a magnetic field B and an electric field E, is derived. It is shown that if the principal components of the nuclear magnetic shielding tensor σ and the dipole moment μe are known, then the measurement of the transverse component to the magnetic field B of the nuclear magnetization, which is induced by the application of the electric field oscillating at the half of the spin precession frequency, allows determining the orientation of the dipole moment μe with respect to the principal axis system of the symmetric part of the tensor σ. Four-component relativistic density functional theory computations, which have been performed for several molecules containing heavy nuclei, i.e., 207Pb, 205Tl, 199Hg, 195Pt, and 125Te, indicate that coefficients of the relaxation matrix perturbed by the electric field E are in favorable cases of the order of 1000 pm2 V-2 T-2. Therefore, the spin dynamics is perturbed at experimentally observable levels for the strengths of electric and magnetic fields E = 5 kV/mm and B = 10 T, respectively.

Implementation of ALARA at the design stage of Nuclear Power Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brissaud, A.; Ridoux, P.

1995-03-01

In the 1970s, Electricite de France (EdF) had limited knowledge and experience of pressurized water reactors (PWRs). Electricity generation by nuclear units was oriented towards gas-graphite reactors, even though EdF had a share in the PWR unit of CHOOZ A-1 (250 MWe, later upgraded to 320 MWe). Some facts about the origin of doses in that king of reactor were known to the research and development (R&D) support staff of EdF, which mainly comprises the French Atomic Commission (CEA), but only a few of EdF`s engineers were aware of these facts. One has to bear in mind that CHOOZ A-1more » only went critical in April 1967 and was officially connected to the grid in May 1970 after some important problems had been solved. Meanwhile, the nuclear program was launched at full speed, beginning with the order for FESSENHEIM 1 in 1970, FESSENHEIM 2 and BUGEY 2 and 3 in 1971. TIHANGE 1, in which EdF had a share, went on-line in September 1975. Also, supposing that EdF had had such knowledge and experience, it is quite evident that it would have been very difficult to modify the lay-out inside the reactor building.« less

Host Galaxies, Obscuration, and Nuclear Structure of Three Nearby Compact Symmetric Objects

NASA Astrophysics Data System (ADS)

Perlman, Eric S.; Stocke, John T.; Conway, John; Reynolds, Chris

2001-08-01

We present three-band Hubble Space Telescope imaging of three nearby (z<=0.1) compact symmetric objects: 4C 31.04, 1946+708, and 1146+596. These objects were chosen on the basis of proximity to Earth as well as H I 21 cm line absorption. The inner H-band isophotes of these galaxies are well fitted by Nuker models, typical of nearby elliptical galaxies. Each shows a significant flattening in the isophotal profile at radii ~0.5", as well as significant variations in ellipticity and P.A. However, as previous authors have noted, neither is uncommon for elliptical galaxies. All three objects show modest departures from Nuker law models at radii of 1-5 h-160 kpc. Each galaxy shows large well-distributed dust features, which are somewhat concentrated in the nuclear regions in features that resemble disks or tori. We find that the amount of dust in these galaxies is about 10 times higher than normal for elliptical galaxies and radio galaxy hosts. The major axes of the nuclear dust disks tend to be oriented roughly perpendicular to the radio axis. One galaxy, 4C 31.04, exhibits bright nuclear regions well aligned with the radio axis, while another, 1146+596, shows a significant near-IR excess resembling a stellar bar along its dust disk. The combination of outwardly normal isophotal profiles with significant variations in P.A. and ellipticity is consistent with the host galaxies being relatively recent merger remnants and the mergers having occurred >~108 yr ago. Such a merger could have ``triggered'' the onset of the current active phase seen in these objects, but our data require a significant time delay between the merger event and the onset of nuclear activity. However, these data are also consistent with the hypothesis that the onset of nuclear activity in radio galaxies is due to relatively minor ``feeding'' events and/or the formation of ``bars within bars,'' events which would disturb the internal kinematics only slightly.

Firm performance model in small and medium enterprises (SMEs) based on learning orientation and innovation

NASA Astrophysics Data System (ADS)

Lestari, E. R.; Ardianti, F. L.; Rachmawati, L.

2018-03-01

This study investigated the relationship between learning orientation, innovation, and firm performance. A conceptual model and hypothesis were empirically examined using structural equation modelling. The study involved a questionnaire-based survey of owners of small and medium enterprises (SMEs) operating in Batu City, Indonesia. The results showed that both variables of learning orientation and innovation effect positively on firm performance. Additionally, learning orientation has positive effect innovation. This study has implication for SMEs aiming at increasing their firm performance based on learning orientation and innovation capability.

Use of abnormal preprophase bands to decipher division plane determination

NASA Technical Reports Server (NTRS)

Granger, C.; Cyr, R.

2001-01-01

Many premitotic plant cells possess a cortical preprophase band of microtubules and actin filaments that encircles the nucleus. In vacuolated cells, the preprophase band is visibly connected to the nucleus by a cytoplasmic raft of actin filaments and microtubules termed the phragmosome. Typically, the location of the preprophase band and phragmosome corresponds to, and thus is thought to influence, the location of the cell division plane. To better understand the function of the preprophase band and phragmosome in orienting division, we used a green fluorescent protein-based microtubule reporter protein to observe mitosis in living tobacco bright yellow 2 cells possessing unusual preprophase bands. Observations of mitosis in these unusual cells support the involvement of the preprophase band/phragmosome in properly positioning the preprophase nucleus, influencing spindle orientation such that the cytokinetic phragmoplast initially grows in an appropriate direction, and delineating a region in the cell cortex that attracts microtubules and directs later stages of phragmoplast growth. Thus, the preprophase band/phragmosome appears to perform several interrelated functions to orient the division plane. However, functional information associated with the preprophase band is not always used or needed and there appears to be an age or distance-dependent character to the information. Cells treated with the anti-actin drug, latrunculin B, are still able to position the preprophase nucleus suggesting that microtubules may play a dominant role in premitotic positioning. Furthermore, in treated cells, spindle location and phragmoplast insertion are frequently abnormal suggesting that actin plays a significant role in nuclear anchoring and phragmoplast guidance. Thus, the microtubule and actin components of the preprophase band/phragmosome execute complementary activities to ensure proper orientation of the division plane.

Modulation and Functional Role of the Orientations of the N- and P-Domains of Cu+ -Transporting ATPase along the Ion Transport Cycle.

PubMed

Meng, Dan; Bruschweiler-Li, Lei; Zhang, Fengli; Brüschweiler, Rafael

2015-08-18

Ion transport of different P-type ATPases is regulated similarly through the interplay of multiple protein domains. In the presence of ATP, binding of a cation to the ion binding site in the transmembrane helices leads to the phosphorylation of the P-domain, allowing ion transfer across the membrane. The details of the mechanism, however, are not clear. Here, we report the modulation of the orientation between the N- and P-domains of Cu(+)-transporting ATPase along the ion transport cycle using high-resolution nuclear magnetic resonance spectroscopy in solution. On the basis of residual dipolar coupling measurements, it is found that the interdomain orientation (relative openness) of the N- and P-domains is distinctly modulated depending on the specific state of the N- and P-domains along the ion translocation cycle. The two domains' relative position in the apo state is semiopen, whereas it becomes closed upon binding of ATP to the N-domain. After phosphorylation of the P-domain and the release of ADP, the opening, however, becomes the widest among all the states. We reason such wide opening resulting from the departure of ADP prepares the N- and P-domains to accommodate the A-domain for interaction and, hence, promote ion transport and allow dephosphorylation of the P-domain. Such wide interdomain opening is abolished when an Asn to Asp mutation is introduced into the conserved DXXK motif located in the hinge region of the N- and P-domains of Cu(+)-ATPase, suggesting the indispensible role of the N- and P-interdomain orientation during ion transportation. Our results shed new light on the structural and mechanistic details of P-type ATPase function at large.

For the love of learning science: Connecting learning orientation and career productivity in physics and chemistry

NASA Astrophysics Data System (ADS)

Hazari, Zahra; Potvin, Geoff; Tai, Robert H.; Almarode, John

2010-06-01

An individual’s motivational orientation serves as a drive to action and can influence their career success. This study examines how goal orientation toward the pursuit of a graduate degree in physics and chemistry influences later success outcomes of practicing physicists and chemists. Two main categories of goal orientation are examined in this paper: performance orientation or motivation to demonstrate one’s ability or performance to others, and learning orientation or motivation through the desire to learn about a topic. The data were obtained as part of Project Crossover, a mixed-methods study which focused on studying the transition from graduate student to scientist in the physical sciences and included a survey of members of two national professional physical science organizations. Using regression analysis on data from 2353 physicists and chemists, results indicate that physicists and chemists who reported a learning orientation as their motivation for going to graduate school were more productive, in terms of total career primary and/or first-author publications and grant funding, than those reporting a performance orientation. Furthermore, given equal salary, learning-oriented individuals produced more primary and/or first-author publications than their nonlearning oriented counterparts.

Culture and social hierarchy: Self- and other-oriented correlates of socioeconomic status across cultures.

PubMed

Miyamoto, Yuri; Yoo, Jiah; Levine, Cynthia S; Park, Jiyoung; Boylan, Jennifer Morozink; Sims, Tamara; Markus, Hazel Rose; Kitayama, Shinobu; Kawakami, Norito; Karasawa, Mayumi; Coe, Christopher L; Love, Gayle D; Ryff, Carol D

2018-05-17

Current theorizing on socioeconomic status (SES) focuses on the availability of resources and the freedom they afford as a key determinant of the association between high SES and stronger orientation toward the self and, by implication, weaker orientation toward others. However, this work relies nearly exclusively on data from Western countries where self-orientation is strongly sanctioned. In the present work, we predicted and found that especially in East Asian countries, where other-orientation is strongly sanctioned, high SES is associated with stronger other-orientation as well as with self-orientation. We first examined both psychological attributes (Study 1, N = 2,832) and socialization values (Study 2a, N = 4,675) in Japan and the United States. In line with the existent evidence, SES was associated with greater self-oriented psychological attributes and socialization values in both the U.S. and Japan. Importantly, however, higher SES was associated with greater other orientation in Japan, whereas this association was weaker or even reversed in the United States. Study 2b (N = 85,296) indicated that the positive association between SES and self-orientation is found, overall, across 60 nations. Further, Study 2b showed that the positive association between SES and other-orientation in Japan can be generalized to other Confucian cultures, whereas the negative association between SES and other-orientation in the U.S. can be generalized to other Frontier cultures. Implications of the current findings for modernization and globalization are discussed. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Selection of Amino Acid Chirality via Neutrino Interactions with 14N in Crossed Electric and Magnetic Fields

PubMed Central

Boyd, Richard N.; Kajino, Toshitaka; Onaka, Takashi

2018-01-01

Abstract Previous work has suggested that the chirality of the amino acids could be established in the magnetic field of a nascent neutron star from a core-collapse supernova or massive collapsar. The magnetic field would orient the 14N nuclei, and the alignment of its nuclear spin with respect to those of the electron antineutrinos emitted from the collapsing star would determine the probability of destruction of the 14N nuclei by interactions with the antineutrinos. Subsequent work estimated the bulk polarization of the 14N nuclei in large rotating meteoroids in such an environment. The present work adds a crucial piece of this model by describing the details by which the selective 14N nuclear destruction would produce molecular chiral selectivity. The effects of the neutrino-induced interactions on the 14N nuclei bound in amino acids polarized in strong magnetic fields are studied. It is shown that electric fields in the reference frame of the nuclei modify the magnetic field at the nucleus, creating nuclear magnetizations that are asymmetric in chirality. The antineutrino cross sections depend on this magnetization, creating a selective destructive effect. The environmental conditions and sites in which such a selection mechanism could occur are discussed. Selective destruction of D-enantiomers results in enantiomeric excesses which may be sufficient to drive subsequent autocatalysis necessary to produce the few-percent enantiomeric excesses found in meteorites and subsequent homochirality. Molecular quantum chemical calculations were performed for alanine, and the chirality-dependent effects studied were included. A preference for left-handed molecules was found, and enantiomeric excesses as high as 0.02% were estimated for molecules in the electromagnetic conditions expected from a core-collapse supernova. Key Words: Amino acids—Supernovae—Antineutrinos—Enantiomeric excess—Chirality. Astrobiology 18, 190–206. PMID:29160728

The phylogeny of the family Lacertidae (Reptilia) based on nuclear DNA sequences: convergent adaptations to arid habitats within the subfamily Eremiainae.

PubMed

Mayer, Werner; Pavlicev, Mihaela

2007-09-01

The family Lacertidae encompasses more than 250 species distributed in the Palearctis, Ethiopis and Orientalis. Lacertids have been subjected in the past to several morphological and molecular studies to establish their phylogeny. However, the problems of convergent adaptation in morphology and of excessively variable molecular markers have hampered the establishment of well supported deeper phylogenetic relationships. Particularly the adaptations to xeric environments have often been used to establish a scenario for the origin and radiation of major lineages within lacertids. Here we present a molecular phylogenetic study based on two nuclear marker genes and representatives of 37 lacertid genera and distinct species groups (as in the case of the collective genus Lacerta). Roughly 1600 bp of the nuclear rag1 and c-mos genes were sequenced and analyzed. While the results provide good support to the hitherto suggested main subfamilies of Gallotiinae (Gallotia and Psammodromus), Eremiainae and Lacertinae [Harris, D.J., Arnold, E.N., Thomas, R.H., 1998. Relationships of lacertid lizards (Reptilia: Lacertidae) estimated from mitochondrial DNA sequences and morphology. Proc. R. Soc. Lond. B 265, 1939-1948], they also suggest unexpected relationships. In particular, the oriental genus Takydromus, previously considered the sister-group to the three subfamilies, is nested within Lacertinae. Moreover, the genera within the Eremiainae are further divided into two groups, roughly corresponding to their respective geographical distributions in the Ethiopian and the Saharo-Eurasian ranges. The results support an independent origin of adaptations to xeric conditions in different subfamilies. The relationships within the subfamily Lacertinae could not be resolved with the markers used. The species groups of the collective genus Lacerta show a bush-like topology in the inferred Bayesian tree, suggesting rapid radiation. The composition of the subfamilies Eremiainae and Lacertinae as well as their phylogeography are discussed.

Possibilities of the Integration of the Method of the Ecologically Oriented Independent Scientific Research in the Study Process

NASA Astrophysics Data System (ADS)

Grizans, Jurijs; Vanags, Janis

2010-01-01

The aim of this paper is to analyse possibilities of the integration of the method of the ecologically oriented independent scientific research in the study process. In order to achieve the set aim, the following scientific research methods were used: analysis of the conceptual guidelines for the development of environmentally oriented entrepreneurship, interpretation of the experts' evaluation of the ecologically oriented management, analysis of the results of the students' ecologically oriented independent scientific research, as well as monographic and logically constructive methods. The results of the study give an opportunity to make conclusions and to develop conceptual recommendations on how to introduce future economics and business professionals with the theoretical and practical aspects of ecologically oriented management during the study process.

Impacts of fiber orientation and milling on observed crystallinity in jack pine

Treesearch

Umesh P. Agarwal; Sally A. Ralph; Richard S. Reiner; Roderquita K. Moore; Carlos Baez

2014-01-01

Influences of fiber orientation and milling on wood cellulose crystallinity were studied using jack pine wood. The fiber orientation effects were measured by sampling rectangular wood blocks in radial, tangential, and cross-sectional orientations. The influence of milling was studied by analyzing the unsieved and sieved milled wood fractions (all

Wilhelm von Humboldt and the "Orient": On Edward W. Said's Remarks on Humboldt's Orientalist Studies

ERIC Educational Resources Information Center

Messling, Markus

2008-01-01

From an epistemological perspective, Wilhelm von Humboldt's studies on the Oriental and East Asian languages and writing systems (Egyptian hieroglyphs, Sanskrit, Chinese, Polynesian) raise the question of his position in the Orientalist discourse of his time. Said [Said, E.W., 1978. "Orientalism. Western Conceptions of the Orient, fourth…

Relationship between Running Speed and Cognitive Processes in Orienteering: Two Empirical Studies.

ERIC Educational Resources Information Center

Cheshikhina, Valentina V.

1993-01-01

Fourteen qualified orienteers completed a stepwise increased treadmill velocity test in which controls had to be transferred from a master map. Orienteering accuracy was greatest at the anaerobic threshold speed. In a second study, 17 orienteers performed arithmetic tasks before and after a treadmill workout. Performance was significantly better…

For the Love of Science: Learning Orientation and Physical Science Success

NASA Astrophysics Data System (ADS)

Hazari, Zahra; Potvin, Geoff; Tai, Robert; Almarode, John

2010-02-01

An individual's motivational orientation serves as a drive to action and can influence their productivity. This study examines how the goal orientation of students towards the pursuit of their graduate degree in physics and chemistry influences their future success outcomes as practicing scientists. Two main orientations are focused on: performance (or ego/ability) orientation and learning (or task/mastery) orientation. The data was obtained as part of Project Crossover, which applied a mixed methodological approach to studying the transition from graduate student to scientist in the physical sciences. Using regression analysis on survey data from 2353 PhD holders in physics and chemistry, we found that individuals exhibiting a learning orientation were more productive than those exhibiting a performance orientation in terms of first-author publications and grant funding. Furthermore, given equal salary, learning-oriented physical scientists produced more first-author publications than average. )

Gender differences in positive life orientation among the nursing home elders in China: A cross-sectional study.

PubMed

Jin, Cheng; Zheng, Zhibo; Xian, Wei; Bai, Ming; Jin, Liying; Li, Yuting; Yang, Xiufei; Sheng, Yang; Ai, Wensi; Liu, Hongbo

2017-09-01

Life orientation among the nursing home elders would differ from those of community-dwelling elders due to the different living environment, but may have greater differences in gender. This study was designed to investigate the positive life orientation and explore the potential risk factors including gender disparities among nursing home elders in China. This cross-sectional study was conducted in Northeast China. Two steps cluster sampling procedure were chosen. Basic activities of daily living (BADL) and instrumental activities of daily living (IADL) systems were used to estimate the functional status. Positive life orientation was measured using the six-question life orientation scale (LOS). 2512 nursing home elders were enrolled in the study. The mean age of the participants was 73.14±6.746years. Of the 1308 men and 1204 women, 14.9% had a positive life orientation in women and 16.1% in men. Higher level of education, independent in BADL and IADL were related to positive life orientation both in men and women. Age and BMI were also found to be significantly associated with positive life orientation in men (OR=0.587, 1.132, respectively). For women, the influence of income and vision on positive life orientation was also significant (OR=1.967, 1.926, respectively). The positive life orientation was higher in men than women. The gender-specific differences contribute to take more effective measures to improve the positive life orientation. Copyright © 2017 Elsevier B.V. All rights reserved.

Public perceptions of the risks of an unfamiliar technology: The case of using nuclear energy sources for space missions

NASA Astrophysics Data System (ADS)

Maharik, Michael

This thesis addresses the public perception of the risk of a technology not widely known to laypeople. Its aims were (1) to characterize public perceptions of the risk of using nuclear energy in space and decisions related to this risk, and (2) to extend the 'mental model' methodology to studying public perception of unfamiliar, risky technologies. A model of the physical processes capable of creating risks from using nuclear energy sources in space was first constructed. Then, knowledge and beliefs related to this topic were elicited from three different groups of people. The generality of the findings was examined in a constructive replication with environmentally-oriented people. The possibility of involving the public in decision-making processes related to engineering macro-design was then investigated. Finally, a communication regarding these risk processes was developed and evaluated in an experiment comparing it with communications produced by NASA. Although they included large portions of the expert model, people's beliefs also had gaps and misconceptions. Respondents often used scientific terms without a clear understanding of what they meant. Respondents' mental models sometimes contained scattered and inconsistent entries. The impact of pre-existing mental models was clearly seen. Different groups of people had different patterns of knowledge and beliefs. Nevertheless, respondents expressed reasonable and coherent opinions on choices among engineering options. The CMU brochure, derived from the study of readers' existing mental models, provided a better risk communication tool than NASA's material, reflecting primarily experts' perspective. The better performance of subjects reading either brochure generally reflected adding knowledge on issues that they had not previously known, rather than correcting wrong beliefs. The communication study confirmed a hypothesis that improving knowledge on risk processes related to the use of a technology causes a more favorable attitude towards that technology. Recommendations related to the design and targeting of risk communication, and to public participation in decision-making on using new and risky technologies, are derived. Additional studies that will elicit laypeople's definitions of risk related to specific technologies, and link their detailed understanding of risk-development processes to the perceived dimensions of risk, are suggested.

Collectivistic orientation, acculturative stress, cultural self-efficacy, and depression: A longitudinal study among Chinese internal migrants

PubMed Central

Du, Hongfei; Li, Xiaoming; Lin, Danhua; Tam, Cheuk Chi

2014-01-01

The current study examined the longitudinal relationship of collectivistic orientation and depression and the mediating effects of acculturative stress and cultural self-efficacy between collectivistic orientation and depression. We expect that collectivistic orientation would decrease acculturative stress and increase cultural self-efficacy, and in turn, improve depression. Using data from 641 Chinese internal migrants during a one-year period, the results supported the hypothesis that collectivistic orientation predicted decreased depression. Moreover, collectivistic orientation alleviated depression through reducing acculturative stress. Although cultural self-efficacy was also a significant mediator, collectivistic orientation relieved depression through decreasing cultural self-efficacy. Implications for future research directions and counseling are discussed. PMID:25480108

Feeling Better When Someone Is Alike: Poor Emotion Regulators Profit From Pro-Social Values and Priming for Similarities With Close Others.

PubMed

Chatterjee, Monischa B; Baumann, Nicola; Koole, Sander L

2017-12-01

The dispositional inability to self-regulate one's own emotions intuitively is described as state orientation and has been associated with numerous psychological impairments. The necessity to search for buffering effects against negative outcomes of state orientation is evident. Research suggests that state-oriented individuals can benefit from feeling close to others. Yet, there are individual differences in the extent to which supportive relationships are valued. The objective of the present article was to examine whether high importance of relatedness increases the utilization of its situational activation among state-oriented individuals. In two studies, we examined whether situational activation of relatedness (by priming for similarities with a close other) is particularly advantageous for state-oriented individuals who attach high importance to relatedness (i.e., benevolence values). The sample consisted of 170 psychology undergraduates in Study 1 and 177 in Study 2. In both studies, state-oriented participants high in benevolence had reduced negative mood after thinking about similarities (vs. differences). State-oriented participants low in benevolence did not benefit from priming for similarities. In Study 2, physical presence of a close other did not boost priming effects for state-oriented participants but stimulated action-oriented participants to attune their self-regulatory efforts to the context. The results show that state-oriented individuals who value benevolence do benefit from a situational activation of relatedness. © 2016 Wiley Periodicals, Inc.

A conditioned visual orientation requires the ellipsoid body in Drosophila

PubMed Central

Guo, Chao; Du, Yifei; Yuan, Deliang; Li, Meixia; Gong, Haiyun; Gong, Zhefeng

2015-01-01

Orientation, the spatial organization of animal behavior, is an essential faculty of animals. Bacteria and lower animals such as insects exhibit taxis, innate orientation behavior, directly toward or away from a directional cue. Organisms can also orient themselves at a specific angle relative to the cues. In this study, using Drosophila as a model system, we established a visual orientation conditioning paradigm based on a flight simulator in which a stationary flying fly could control the rotation of a visual object. By coupling aversive heat shocks to a fly's orientation toward one side of the visual object, we found that the fly could be conditioned to orientate toward the left or right side of the frontal visual object and retain this conditioned visual orientation. The lower and upper visual fields have different roles in conditioned visual orientation. Transfer experiments showed that conditioned visual orientation could generalize between visual targets of different sizes, compactness, or vertical positions, but not of contour orientation. Rut—Type I adenylyl cyclase and Dnc—phosphodiesterase were dispensable for visual orientation conditioning. Normal activity and scb signaling in R3/R4d neurons of the ellipsoid body were required for visual orientation conditioning. Our studies established a visual orientation conditioning paradigm and examined the behavioral properties and neural circuitry of visual orientation, an important component of the insect's spatial navigation. PMID:25512578

Customer orientation among employees in public administration: a transnational, longitudinal study.

PubMed

Korunka, Christian; Scharitzer, Dieter; Carayon, Pascale; Hoonakker, Peter; Sonnek, Angelika; Sainfort, Francois

2007-05-01

The relation between ergonomic principles and quality management initiatives, both, in the private and public sector, has received increasing attention in the recent years. Customer orientation among employees is not only an important quality principle, but also an essential prerequisite for customer satisfaction, especially in service organizations. In this context, the objective of introducing new public management (NPM) in public-service organizations is to increase customer orientation among employees who are at the forefront of service providing. In this study, we developed a short scale to measure perceived customer orientation. In two separate longitudinal studies carried out in Austria and the US, we analyzed changes in customer orientation resulting from the introduction of NPM. In both organizations, we observed a significant increase in customer orientation. Perceived customer orientation was related to job characteristics, organizational characteristics and employee quality of working life. Creating positive influences on these characteristics within the framework of an organizational change process has positive effects on employee customer orientation.

University Students' Study Orientations, Learning Experiences and Study Success in Innovative Courses

ERIC Educational Resources Information Center

Honkimaki, Sanna; Tynjala, Paivi; Valkonen, Sakari

2004-01-01

The aim of this study was to find out whether university students' study orientations on four innovative courses differed from their usual orientations to their studies. Furthermore, students' study success and learning experiences were examined. The pedagogical innovations carried out on the courses included different kinds of activating…

Phase Transition of H 2 in Subnanometer Pores Observed at 75 K

DOE PAGES

Olsen, Raina J.; Gillespie, Andrew K.; Contescu, Cristian I.; ...

2017-10-30

In this paper, we report a phase transition in H 2 adsorbed in a locally graphitic Saran carbon with subnanometer pores 0.5–0.65 nm in width, in which two layers of hydrogen can just barely squeeze, provided they pack tightly. The phase transition is observed at 75 K, temperatures far higher than other systems in which an adsorbent is known to increase phase transition temperatures: for instance, H 2 melts at 14 K in the bulk, but at 20 K on graphite because the solid H 2 is stabilized by the surface structure. Here we observe a transition at 75 Kmore » and 77–200 bar: from a low-temperature, low-density phase to a high-temperature, higher density phase. We model the low-density phase as a monolayer commensurate solid composed mostly of para-H 2 (the ground nuclear spin state, S = 0) and the high-density phase as an orientationally ordered bilayer commensurate solid composed mostly of ortho-H 2 (S = 1). We attribute the increase in density with temperature to the fact that the oblong ortho-H 2 can pack more densely. The transition is observed using two experiments. The high-density phase is associated with an increase in neutron backscatter by a factor of 7.0 ± 0.1. Normally, hydrogen produces no backscatter (scattering angle >90°). This backscatter appears along with a discontinuous increase in the excitation mass from 1.2 amu to 21.0 ± 2.3 amu, which we associate with collective nuclear spin excitations in the orientationally ordered phase. Film densities were measured using hydrogen adsorption. Finally, no phase transition was observed in H 2 adsorbed in control activated carbon materials.« less

Phase Transition of H 2 in Subnanometer Pores Observed at 75 K

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olsen, Raina J.; Gillespie, Andrew K.; Contescu, Cristian I.

In this paper, we report a phase transition in H 2 adsorbed in a locally graphitic Saran carbon with subnanometer pores 0.5–0.65 nm in width, in which two layers of hydrogen can just barely squeeze, provided they pack tightly. The phase transition is observed at 75 K, temperatures far higher than other systems in which an adsorbent is known to increase phase transition temperatures: for instance, H 2 melts at 14 K in the bulk, but at 20 K on graphite because the solid H 2 is stabilized by the surface structure. Here we observe a transition at 75 Kmore » and 77–200 bar: from a low-temperature, low-density phase to a high-temperature, higher density phase. We model the low-density phase as a monolayer commensurate solid composed mostly of para-H 2 (the ground nuclear spin state, S = 0) and the high-density phase as an orientationally ordered bilayer commensurate solid composed mostly of ortho-H 2 (S = 1). We attribute the increase in density with temperature to the fact that the oblong ortho-H 2 can pack more densely. The transition is observed using two experiments. The high-density phase is associated with an increase in neutron backscatter by a factor of 7.0 ± 0.1. Normally, hydrogen produces no backscatter (scattering angle >90°). This backscatter appears along with a discontinuous increase in the excitation mass from 1.2 amu to 21.0 ± 2.3 amu, which we associate with collective nuclear spin excitations in the orientationally ordered phase. Film densities were measured using hydrogen adsorption. Finally, no phase transition was observed in H 2 adsorbed in control activated carbon materials.« less

Control of electron spin decoherence in nuclear spin baths

NASA Astrophysics Data System (ADS)

Liu, Ren-Bao

2011-03-01

Nuclear spin baths are a main mechanism of decoherence of spin qubits in solid-state systems, such as quantum dots and nitrogen-vacancy (NV) centers of diamond. The decoherence results from entanglement between the electron and nuclear spins, established by quantum evolution of the bath conditioned on the electron spin state. When the electron spin is flipped, the conditional bath evolution is manipulated. Such manipulation of bath through control of the electron spin not only leads to preservation of the center spin coherence but also demonstrates quantum nature of the bath. In an NV center system, the electron spin effectively interacts with hundreds of 13 C nuclear spins. Under repeated flip control (dynamical decoupling), the electron spin coherence can be preserved for a long time (> 1 ms) . Thereforesomecharacteristicoscillations , duetocouplingtoabonded 13 C nuclear spin pair (a dimer), are imprinted on the electron spin coherence profile, which are very sensitive to the position and orientation of the dimer. With such finger-print oscillations, a dimer can be uniquely identified. Thus, we propose magnetometry with single-nucleus sensitivity and atomic resolution, using NV center spin coherence to identify single molecules. Through the center spin coherence, we could also explore the many-body physics in an interacting spin bath. The information of elementary excitations and many-body correlations can be extracted from the center spin coherence under many-pulse dynamical decoupling control. Another application of the preserved spin coherence is identifying quantumness of a spin bath through the back-action of the electron spin to the bath. We show that the multiple transition of an NV center in a nuclear spin bath can have longer coherence time than the single transition does, when the classical noises due to inhomogeneous broadening is removed by spin echo. This counter-intuitive result unambiguously demonstrates the quantumness of the nuclear spin bath. This work was supported by Hong Kong RGC/GRF CUHK402207, CUHK402209, and CUHK402410. The author acknowledges collaboration with Nan Zhao, Jian-Liang Hu, Sai Wah Ho, Jones T. K. Wan, and Jiangfeng Du.

The past is the key to the future

USGS Publications Warehouse

Doe, B.R.

1983-01-01

A new major frontier of geological research, which was initiated in the 1970's, involves predicting future geologic trends or events through study of the present and past, rather than trying to understand the past, often using what one knows about the present. Like most scientific frontiers, this one began from practical considerations-environmental concerns. The lack of formal recognition of this frontier results from fragmentation among many Federal agencies and highly focused mission-oriented programs (e.g., earthquake prediction, CO2, nuclear-energy safety, etc.). Most programs aim to predict only the next 50-100 years, but much longer periods of the past need to be studied to do this. Nuclear-waste disposal has sometimes been considered in terms of the next million years, a period of time permitting significant and broad geologic changes. Decreasing public interest in environmental concerns relegates many questions from the realm of applied research back to that of basic research. Most of these questions are so fascinating, however, that the frontier is still worth pursuing. Such questions include whether a phenomenon will or will not take place and the rates at which it can develop (e.g., how fast do rifts form, how fast can a caldera event begin, and how quickly can a glacial maximum arrive?). Common elements of all studies include the historic record, trends in the Quaternary, analogues in various periods of the geologic time scale, and allowance for phenomena never experienced before. Other examples of studies include the Cretaceous as a period of a climatic extreme, an especially interesting time period; establishing the amount of paleocloudiness, a particularly challenging and important research area; acid rain as a possible new phenomenon. Geochemistry has much to contribute to this frontier science. ?? 1983.

Look Here! The Development of Attentional Orienting to Symbolic Cues

ERIC Educational Resources Information Center

Jakobsen, Krisztina Varga; Frick, Janet E.; Simpson, Elizabeth A.

2013-01-01

Although much research has examined the development of orienting to social directional cues (e.g., eye gaze), little is known about the development of orienting to nonsocial directional cues, such as arrows. Arrow cues have been used in numerous studies as a means to study attentional orienting, but the development of children's understanding of…

Two Studies of the Empirical Basis of Two Learning Resource-Oriented Motivational Strategies for Gifted Educators

ERIC Educational Resources Information Center

Vladut, Anamaria; Vialle, Wilma; Ziegler, Albert

2016-01-01

Two learning resource-oriented motivational strategies for gifted educators are introduced: a homeostatic orientation that aims for balance and an allostatic orientation that aims at growth. In order to establish the empirical basis of these motivational strategies, two studies were conducted with samples of students from a specialized…

Vesicle Size Distribution as a Novel Nuclear Forensics Tool

DOE PAGES

Donohue, Patrick H.; Simonetti, Antonio

2016-09-22

The first nuclear bomb detonation on Earth involved a plutonium implosion-type device exploded at the Trinity test site (33°40'38.28"N, 106°28'31.44"W), White Sands Proving Grounds, near Alamogordo, New Mexico. Melting and subsequent quenching of the local arkosic sand produced glassy material, designated “Trinitite”. In cross section, Trinitite comprises a thin (1–2 mm), primarily glassy surface above a lower zone (1–2 cm) of mixed melt and mineral fragments from the precursor sand. Multiple hypotheses have been put forward to explain these well-documented but heterogeneous textures. In this study, we report the first quantitative textural analysis of vesicles in Trinitite to constrain theirmore » physical and thermal history. Vesicle morphology and size distributions confirm the upper, glassy surface records a distinct processing history from the lower region, that is useful in determining the original sample surface orientation. Specifically, the glassy layer has lower vesicle density, with larger sizes and more rounded population in cross-section. This vertical stratigraphy is attributed to a two-stage evolution of Trinitite glass from quench cooling of the upper layer followed by prolonged heating of the subsurface. Finally, defining the physical regime of post-melting processes constrains the potential for surface mixing and vesicle formation in a post-detonation environment.« less

Effects of phalloidin microinjection and localization of fluorescein-labeled phalloidin in living sand dollar eggs.

PubMed

Hamaguchi, Y; Mabuchi, I

1982-01-01

Effects of microinjection of phalloidin on fertilization and cleavage of sand dollar (Clypeaster japonicus and Scaphechinus mirabilis) eggs were studied. The drug, previously injected into unfertilized eggs, showed no effect on the elevation of the fertilization membrane upon insemination up to an intracellular concentration of 50 microM. However, the movement of the egg pronucleus to the sperm pronucleus was inhibited and the fusion of pronuclei did not occur. The subsequent development no longer took place. When phalloidin was injected into fertilized eggs, the thickness of the cortical layer increased and the microvilli became conspicuous. Both nuclear division and cleavage were inhibited at the intracellular concentration of more than 20 microM, though the latter seemed to be more sensitive to phalloidin than the former. Fluorescein-labeled phalloidin (FL-phalloidin) was injected into eggs in order to investigate F-actin localization by fluorescence microscopy. In both unfertilized and fertilized eggs, FL-phalloidin was localized in the cortical layer within 1 min after injection. It was also localized in the cortical layer as radially oriented rod-like structures when injected into fertilized eggs before the disappearance of the nuclear membrane. No distinct fluorescence was detected in the mitotic apparatus or in the cleavage furrow. FL-phalloidin redistributed gradually into egg cytoplasm. In unfertilized eggs, fluorescent rods were found especially in the egg pronucleus 30 min after injection.

Inhibition of Macrophage Nuclear Factor-κB Leads to a Dominant Anti-Inflammatory Phenotype that Attenuates Glomerular Inflammation in Vivo

PubMed Central

Wilson, Heather M.; Chettibi, Salah; Jobin, Christian; Walbaum, David; Rees, Andrew J.; Kluth, David C.

2005-01-01

Infiltrating macrophages (mφ) can cause injury or facilitate repair, depending on how they are activated by the microenvironment. Studies in vitro have defined the roles of individual cytokines and signaling pathways in activation, but little is known about how macrophages integrate the multiple signals they receive in vivo. We inhibited nuclear factor-κB in bone marrow-derived macrophages (BMDMs) by using a recombinant adenovirus expressing dominant-negative IκB (Ad-IκB). This re-orientated macrophage activation so they became profoundly anti-inflammatory in settings where they would normally be classically activated. In vitro, the lipopolysaccharide-induced nitric oxide, interleukin-12, and tumor necrosis factor-α synthesis was abrogated while interleukin-10 synthesis increased. In vivo, fluorescently labeled BMDMs transduced with Ad-IκB and injected into the renal artery significantly reduced inducible nitric oxide synthase and MHC class II expression when activated naturally in glomeruli of rats with nephrotoxic nephritis. Furthermore, although they only comprised 15% of glomerular macrophages, their presence significantly reduced glomerular infiltration and activation of host macrophages. Injury in nephrotoxic nephritis was also decreased when assessed morphologically and by severity of albuminuria. The results demonstrate the power of Ad-IκB-transduced BMDMs to inhibit injury when activated by acute immune-mediated inflammation within the glomerulus. PMID:15972949

X-ray absorption spectroscopy and EPR studies of oriented spinach thylakoid preparations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andrews, J.C.

In this study, oriented Photosystem II (PS II) particles from spinach chloroplasts are studied with electron paramagnetic resonance (EPR) and x-ray absorption spectroscopy (XAS) to determine more details of the structure of the oxygen evolving complex (OEC). The nature of halide binding to Mn is also studied with Cl K-edge and Mn EXAFS (extended x-ray absorption fine structure) of Mn-Cl model compounds, and with Mn EXAFS of oriented PS II in which Br has replaced Cl. Attention is focused on the following: photosynthesis and the oxygen evolving complex; determination of mosaic spread in oriented photosystem II particles from signal IImore » EPR measurement; oriented EXAFS--studies of PS II in the S{sub 2} state; structural changes in PS II as a result of treatment with ammonia: EPR and XAS studies; studies of halide binding to Mn: Cl K-edge and Mn EXAFS of Mn-Cl model compounds and Mn EXAFS of oriented Br-treated photosystem II.« less

Effects of Imidazole Deprotonation on Vibrational Spectra of High-Spin Iron(II) Porphyrinates

PubMed Central

Hu, Chuanjiang; Peng, Qian; Silvernail, Nathan J.; Barabanschikov, Alexander; Zhao, Jiyong; Alp, E. Ercan; Sturhahn, Wolfgang; Sage, J. Timothy; Scheidt, W. Robert

2013-01-01

The effects of the deprotonation of coordinated imidazole on the dynamics of five-coordinate high-spin iron(II) porphyrinates have been investigated using nuclear resonance vibrational spectroscopy. Two complexes have been studied in detail with both powder and oriented single-crystal measurements. Changes in the vibrational spectra are clearly related to structural differences in the molecular structures that occur when imidazole is deprotonated. Most modes involving the simultaneous motion of iron and imidazolate are unresolved but the one mode that is resolved is found at higher frequency in the imidazolates. These out-of-plane results are in accord with earlier resonance Raman studies of heme proteins. We also show the imidazole vs. imidazolate differences in the in-plane vibrations that are not accessible to resonance Raman studies. The in-plane vibrations are at lower frequency in the imidazolate derivatives; the doming mode shifts are inconclusive. The stiffness, an experimentally determined force constant that averages the vibrational details to quantify the nearest-neighbor interactions, confirms that deprotonation inverts the relative strengths of axial and equatorial coordination. PMID:23470205

Is the racial composition of your surroundings associated with your levels of social dominance orientation?

PubMed

Radke, Helena R M; Hornsey, Matthew J; Sibley, Chris G; Thai, Michael; Barlow, Fiona Kate

2017-01-01

We investigate the extent to which minority group members are surrounded by outgroup members in their immediate environment as a predictor of social dominance orientation. Using a large representative sample of New Zealanders, we found that minority group members in outgroup dense environments reported lower levels of social dominance orientation (Study 1). In studies 2 and 3, Asian Australian and Black American participants who were surrounded by outgroup members reported lower social dominance orientation. For majority group (White) participants there was no association between social dominance orientation and outgroup density. Study 4 explained the overall pattern: Black Americans surrounded by outgroup members perceived their group to be of lower status in their immediate environment, and through this, reported lower social dominance orientation. This article adds to growing literature on contextual factors that predict social dominance orientation, especially among minority group members.

Fathers' Orientation to Their Children's Autism Diagnosis: A Grounded Theory Study

ERIC Educational Resources Information Center

Hannon, Michael D.; Hannon, LaChan V.

2017-01-01

Sixteen fathers of individuals with autism were interviewed to develop a grounded theory explaining how they learned about their children's autism diagnosis. Results suggest the orientation process entails at least two phases: orienting oneself and orienting others. The orienting oneself phase entailed fathers having suspicion of developmental…

Petaminer: Using ROOT for efficient data storage in MySQL database

NASA Astrophysics Data System (ADS)

Cranshaw, J.; Malon, D.; Vaniachine, A.; Fine, V.; Lauret, J.; Hamill, P.

2010-04-01

High Energy and Nuclear Physics (HENP) experiments store Petabytes of event data and Terabytes of calibration data in ROOT files. The Petaminer project is developing a custom MySQL storage engine to enable the MySQL query processor to directly access experimental data stored in ROOT files. Our project is addressing the problem of efficient navigation to PetaBytes of HENP experimental data described with event-level TAG metadata, which is required by data intensive physics communities such as the LHC and RHIC experiments. Physicists need to be able to compose a metadata query and rapidly retrieve the set of matching events, where improved efficiency will facilitate the discovery process by permitting rapid iterations of data evaluation and retrieval. Our custom MySQL storage engine enables the MySQL query processor to directly access TAG data stored in ROOT TTrees. As ROOT TTrees are column-oriented, reading them directly provides improved performance over traditional row-oriented TAG databases. Leveraging the flexible and powerful SQL query language to access data stored in ROOT TTrees, the Petaminer approach enables rich MySQL index-building capabilities for further performance optimization.

Modeling pressure-driven assembly of polymer coated nanoparticles

NASA Astrophysics Data System (ADS)

Lane, J. Matthew D.; Salerno, K. Michael; Grest, Gary S.; Fan, Hongyou

2017-06-01

High-pressure experiments have successfully produced a variety of gold nanostructures by compressing polymer coated spherical nanoparticles. We apply atomistic simulation to understand the role of the soft polymer response in determining the pressure-driven assembly of gold nanostructures. Quasi-isentropic experiments have shown that 1D, 2D and 3D nanostructures can be formed and recovered from dynamic compression of fcc superlattices of alkanethiol-coated gold nanocrystals on Sandia's Veloce pulsed power accelerator. Molecular modeling has shown that the dimensionality of the final structures depends on the orientation of the superlattice and the uniaxial loading. We describe the role of coating ligand length and grafting density, on ligand migration and deformation processes during pressure-driven coalescence of the cores into permanent nanowires, nanosheets and 3D structures. The role of uniaxial vs isotropic pressure and the effects of compression along various superlattice orientations will be discussed. Sandia National Laboratories is a multi-mission laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

Outer-Sphere Contributions to the Electronic Structure of Type Zero Copper Proteins

PubMed Central

Lancaster, Kyle M.; Zaballa, María-Eugenia; Sproules, Stephen; Sundararajan, Mahesh; DeBeer, Serena; Richards, John H.; Vila, Alejandro J.; Neese, Frank; Gray, Harry B.

2016-01-01

Bioinorganic canon states that active-site thiolate coordination promotes rapid electron transfer (ET) to and from type 1 copper proteins. In recent work, we have found that copper ET sites in proteins also can be constructed without thiolate ligation (called “type zero” sites). Here we report multifrequency electron paramagnetic resonance (EPR), magnetic circular dichroism (MCD), and nuclear magnetic resonance (NMR) spectroscopic data together with density functional theory (DFT) and spectroscopy-oriented configuration interaction (SORCI) calculations for type zero Pseudomonas aeruginosa azurin variants. Wild-type (type 1) and type zero copper centers experience virtually identical ligand fields. Moreover, O-donor covalency is enhanced in type zero centers relative that in the C112D (type 2) protein. At the same time, N-donor covalency is reduced in a similar fashion to type 1 centers. QM/MM and SORCI calculations show that the electronic structures of type zero and type 2 are intimately linked to the orientation and coordination mode of the carboxylate ligand, which in turn is influenced by outer-sphere hydrogen bonding. PMID:22563915

Mission impossible? - Government Agencies And Public Relations For Nuclear Waste Disposal In Germany

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landsmann, B.; Brauer, V.

2007-07-01

Analyzing the opinion of European Union citizens on the management of radioactive waste a survey of 2005 shows that European citizens are almost unanimous in the need to set up a national strategy for high-level radioactive waste disposal without any delay. While 45% of respondents consider that deep underground disposal represents the most appropriate solution for long-term management of highly radioactive waste, 38% disagree. In Germany, the divergence of opinion in this respect is very distinctive and it shows that, although experts believe that selected sites represent the best solution, this information does not yet seem to have reached themore » public. The reason therefore is both the lack of interesting and comprehensible information of issues related to nuclear waste disposal and negative media reporting always coupled with the negative public opinion about atomic energy in Germany. In Germany the siting, construction, and operation of a repository for radioactive waste is a national task. The Federal Institute for Geosciences and Natural Resources (BGR) as a government agency is a praxis oriented science institution and works on all geo-scientific and geotechnical issues in the German repository projects. According to its guidance BGR feels responsible for the future generations and is acting as a neutral and anticipatory partner for ministries and public authorities as well as a partner for industry, society and scientific bodies. BGR therefore is able to accomplish an essential contribution for the creation of public confidence for radioactive waste disposal due to precise public relations strategies. Sending the following messages is BGR's communication goal: - Radioactive waste can safely be disposed of in deep geological formations; - BGR is capable to handle this duty and delivers reliable results. Thereby, the BGR is in particular interested in passing on the information about nuclear waste disposal in a current and comprehensible way as well as providing arguments for the public. Public relations work of an authority should not only be to announce its expertise and consulting competence, but also to operate goal-orientated as a dialog partner and service provider of the community. BGR as an authority meets this challenge with the important advantage of accomplishing scientific research itself and thus delivering information first hand. In the last couple of years the BGR started to build its own public relations about its geo-scientific research. The BGR is planning to handle this dialog continuously, consistently and even strengthen it. Target groups are not only experts like research institutes and universities but also citizens as well as stakeholders and decision-makers. In order to fulfil the requirements of a comprehensive geo-scientific information policy, BGR is continuously enlarging its internet offer to the issue of nuclear waste disposal. The focal point concentrates on current, generally understandable words as well as on a wide offer about expert knowledge. Furthermore, the citizens shall be informed and sensitized about the topic of disposal by continuous media and press work. Through a target group oriented information in dialog with the public, state authorities, such as the BGR, are able to give an important contribution for the objectification of the 'disposal issue' and therefore more acceptance which could lead to more confidence within the population. BGR is analyzing international public relation concepts and is trying to transfer suitable strategies for public communication in Germany. Experience in Public Relations in the last four years have demonstrated that exciting as well as comprehensible information and an active presentation of topics of nuclear waste disposal consistently showed positive reactions and interest among the participants. (authors)« less

A Study on the Difficulties of Learning Phase Transition in Object-Oriented Analysis and Design from the Viewpoint of Semantic Distance

ERIC Educational Resources Information Center

Shin, Shin-Shing

2015-01-01

Students in object-oriented analysis and design (OOAD) courses typically encounter difficulties transitioning from object-oriented analysis (OOA) to logical design (OOLD). This study conducted an empirical experiment to examine these learning difficulties by evaluating differences between OOA-to-OOLD and OOLD-to-object-oriented-physical-design…

The Meaning of Being Predominantly Present-Oriented in Middle Age and in Non-Western Context.

ERIC Educational Resources Information Center

Shirai, Toshiaki

This paper describes a study of time orientation and preferences of people in western and nonwestern cultures at various life stages. Data were gathered by means of a literature review and a time orientation questionnaire completed by 1,657 individuals in Belgium and Japan. Findings of the study suggest that the time orientation that enhances…

Social power facilitates the effect of prosocial orientation on empathic accuracy.

PubMed

Côté, Stéphane; Kraus, Michael W; Cheng, Bonnie Hayden; Oveis, Christopher; van der Löwe, Ilmo; Lian, Hua; Keltner, Dacher

2011-08-01

Power increases the tendency to behave in a goal-congruent fashion. Guided by this theoretical notion, we hypothesized that elevated power would strengthen the positive association between prosocial orientation and empathic accuracy. In 3 studies with university and adult samples, prosocial orientation was more strongly associated with empathic accuracy when distinct forms of power were high than when power was low. In Study 1, a physiological indicator of prosocial orientation, respiratory sinus arrhythmia, exhibited a stronger positive association with empathic accuracy in a face-to-face interaction among dispositionally high-power individuals. In Study 2, experimentally induced prosocial orientation increased the ability to accurately judge the emotions of a stranger but only for individuals induced to feel powerful. In Study 3, a trait measure of prosocial orientation was more strongly related to scores on a standard test of empathic accuracy among employees who occupied high-power positions within an organization. Study 3 further showed a mediated relationship between prosocial orientation and career satisfaction through empathic accuracy among employees in high-power positions but not among employees in lower power positions. Discussion concentrates upon the implications of these findings for studies of prosociality, power, and social behavior.

The biological basis of human sexual orientation: is there a role for epigenetics?

PubMed

Ngun, Tuck C; Vilain, Eric

2014-01-01

Sexual orientation is one of the largest sex differences in humans. The vast majority of the population is heterosexual, that is, they are attracted to members of the opposite sex. However, a small but significant proportion of people are bisexual or homosexual and experience attraction to members of the same sex. The origins of the phenomenon have long been the subject of scientific study. In this chapter, we will review the evidence that sexual orientation has biological underpinnings and consider the involvement of epigenetic mechanisms. We will first discuss studies that show that sexual orientation has a genetic component. These studies show that sexual orientation is more concordant in monozygotic twins than in dizygotic ones and that male sexual orientation is linked to several regions of the genome. We will then highlight findings that suggest a link between sexual orientation and epigenetic mechanisms. In particular, we will consider the case of women with congenital adrenal hyperplasia (CAH). These women were exposed to high levels of testosterone in utero and have much higher rates of nonheterosexual orientation compared to non-CAH women. Studies in animal models strongly suggest that the long-term effects of hormonal exposure (such as those experienced by CAH women) are mediated by epigenetic mechanisms. We conclude by describing a hypothetical framework that unifies genetic and epigenetic explanations of sexual orientation and the continued challenges facing sexual orientation research. Copyright © 2014 Elsevier Inc. All rights reserved.

Characterizing the Achievement Motivation Orientation of Children from Low- and Middle-Income Families

ERIC Educational Resources Information Center

Day, Crystal A.; Burns, Barbara M.

2011-01-01

Research Findings: The current study examined achievement motivation orientation in preschool-age children from low- and middle-income families. Participants were 126 children who were attending an urban Head Start site or a private preschool. Children's motivation orientation was assessed as being performance oriented or mastery oriented using a…

Development of Academic Goal Orientation Inventory for Senior Secondary School Students of Kerala

ERIC Educational Resources Information Center

Gafoor, K. Abdul; Abidha, Kurukkan

2015-01-01

Research interest in achievement motivation and its correlates has grown in recent years. Though there are thousands of studies on goal orientation, the number of instruments to identify goal orientation based on four-fold model viz., performance approach goal orientation (PAP), performance avoidance goal orientation (PAV), mastery approach goal…

The Impact of Market Orientation on Patient Safety Climate Among Hospital Nurses.

PubMed

Weng, Rhay-Hung; Chen, Jung-Chien; Pong, Li-Jung; Chen, Li-Mei; Lin, Tzu-Chi

2016-03-01

Improving market orientation and patient safety have become the key concerns of nursing management. For nurses, establishing a patient safety climate is the key to enhancing nursing quality. This study explores how market orientation affects the climate of patient safety among hospital nurses. We proposed adopting a cross-sectional research design and using questionnaires to collect responses from nurses working in two Taiwanese hospitals. Three-hundred and forty-three valid samples were obtained. Multiple regression and path analyses were conducted to test the study. Market orientation was defined as the combination of customer orientation, competitor orientation, and interfunctional coordination. Customer orientation directly affects the climate of patient safety. Although the findings only supported Hypothesis 1, competitor orientation and interfunctional coordination positively affected the patient safety climate through the mediating effects of hospital support for staff. Health care managers could encourage nurses to adopt customer-oriented perspectives to enhance their nursing care. In addition, to enhance competitor orientation, interfunctional coordination, and the patient safety climate, hospital managers could strengthen their support for staff members. © The Author(s) 2014.

Minnesota anglers' fisheries-related value orientations and their stewardship of fish resources

USGS Publications Warehouse

Bruskotter, J.T.; Fulton, D.C.

2008-01-01

Research on natural resource-related values and value orientations has grown substantially over the past decade. However, existing studies have focused almost exclusively on value orientations related to wildlife and forests. This article reports data from two mail surveys of Minnesota anglers used to develop scales for measuring fisheries-related value orientations. We report results of regression analyses examining the relationship between anglers' value orientations and norms concerning fisheries stewardship and the use of technological aids to angling. Results indicate 10 items reliably measure three value orientations we termed utilitarianism, dominance, and protectionism. Regression analyses suggest anglers' stewardship norms are influenced by all three value orientation types, while support for the use of technological aids was related with protectionism and utilitarianism, but not dominance. Results suggest anglers' fisheries-related value orientations cannot be adequately captured using single domain scales. Implications for the study of natural resources-related value orientations are discussed. Copyright ?? Taylor & Francis Group, LLC.

Improving orientation in head injured adults by repeated practice, multi-sensory input and peer participation.

PubMed

Zencius, A H; Wesolowski, M D; Rodriguez, I M

1998-01-01

The efficacy of using antecedent control procedures (practice, multi-sensory input and peer participation) in facilitating orientation to person, place and time with two survivors of traumatic brain injuries were tested in two studies. In the first investigation, a 23-year-old male was treated by presenting the orientation questions orally while being shown questions on written flashcards. Results suggest that correct responses to orientation questions only occurred when flashcards were coupled with oral questioning. The participant responded correctly to nearly 100% of all orientation questions within 2 weeks of initiating flashcards. In the second study, a 19-year-old male was asked to respond in writing to 20 orientation questions in a small group. The group had a leader and 4 TBI patients. Following this, group members who correctly answered the orientation questions, took turns reading orientation questions and providing the correct responses.

Hails from the crypt: a terror management health model investigation of the effectiveness of health-oriented versus celebrity-oriented endorsements.

PubMed

McCabe, Simon; Vail, Kenneth E; Arndt, Jamie; Goldenberg, Jamie L

2014-03-01

Interfacing the terror management health model with the meaning transfer model, we offer novel hypotheses concerning the effectiveness of celebrity and medical endorsements for consumer products and health behavior decisions. Studies 1 and 2 revealed that, compared with control topic primes, death thoughts in focal attention increased the effectiveness of health-oriented (doctor) endorsers but not culture-oriented (celebrity) endorsers, whereas death thoughts outside of focal attention increased the effectiveness of culture-oriented endorsers but not health-oriented endorsers. Studies 3 and 4 then focus more specifically on the valence and specificity of culture-oriented endorsements, revealing that death thoughts outside focal attention increase the effectiveness of culture-oriented endorsers only on the behaviors specifically endorsed and only when the endorser is characterized as possessing cultural value. Discussion focuses on everyday management of existential concerns and implications for persuasive communications in the health domain.

Is moral elevation an approach-oriented emotion?

PubMed Central

Van de Vyver, Julie; Abrams, Dominic

2017-01-01

Abstract Two studies were designed to test whether moral elevation should be conceptualized as an approach-oriented emotion. The studies examined the relationship between moral elevation and the behavioral activation and inhibition systems. Study 1 (N = 80) showed that individual differences in moral elevation were associated with individual differences in behavioral activation but not inhibition. Study 2 (N = 78) showed that an elevation-inducing video promoted equally high levels of approach orientation as an anger-inducing video and significantly higher levels of approach orientation than a control video. Furthermore, the elevation-inducing stimulus (vs. the control condition) significantly promoted prosocial motivation and this effect was sequentially mediated by feelings of moral elevation followed by an approach-oriented state. Overall the results show unambiguous support for the proposal that moral elevation is an approach-oriented emotion. Applied and theoretical implications are discussed. PMID:28191027

Adaptive multi-resolution 3D Hartree-Fock-Bogoliubov solver for nuclear structure

NASA Astrophysics Data System (ADS)

Pei, J. C.; Fann, G. I.; Harrison, R. J.; Nazarewicz, W.; Shi, Yue; Thornton, S.

2014-08-01

Background: Complex many-body systems, such as triaxial and reflection-asymmetric nuclei, weakly bound halo states, cluster configurations, nuclear fragments produced in heavy-ion fusion reactions, cold Fermi gases, and pasta phases in neutron star crust, are all characterized by large sizes and complex topologies in which many geometrical symmetries characteristic of ground-state configurations are broken. A tool of choice to study such complex forms of matter is an adaptive multi-resolution wavelet analysis. This method has generated much excitement since it provides a common framework linking many diversified methodologies across different fields, including signal processing, data compression, harmonic analysis and operator theory, fractals, and quantum field theory. Purpose: To describe complex superfluid many-fermion systems, we introduce an adaptive pseudospectral method for solving self-consistent equations of nuclear density functional theory in three dimensions, without symmetry restrictions. Methods: The numerical method is based on the multi-resolution and computational harmonic analysis techniques with a multi-wavelet basis. The application of state-of-the-art parallel programming techniques include sophisticated object-oriented templates which parse the high-level code into distributed parallel tasks with a multi-thread task queue scheduler for each multi-core node. The internode communications are asynchronous. The algorithm is variational and is capable of solving coupled complex-geometric systems of equations adaptively, with functional and boundary constraints, in a finite spatial domain of very large size, limited by existing parallel computer memory. For smooth functions, user-defined finite precision is guaranteed. Results: The new adaptive multi-resolution Hartree-Fock-Bogoliubov (HFB) solver madness-hfb is benchmarked against a two-dimensional coordinate-space solver hfb-ax that is based on the B-spline technique and a three-dimensional solver hfodd that is based on the harmonic-oscillator basis expansion. Several examples are considered, including the self-consistent HFB problem for spin-polarized trapped cold fermions and the Skyrme-Hartree-Fock (+BCS) problem for triaxial deformed nuclei. Conclusions: The new madness-hfb framework has many attractive features when applied to nuclear and atomic problems involving many-particle superfluid systems. Of particular interest are weakly bound nuclear configurations close to particle drip lines, strongly elongated and dinuclear configurations such as those present in fission and heavy-ion fusion, and exotic pasta phases that appear in neutron star crust.

Nuclear chemistry of returned lunar samples: Nuclide analysis by gamma-ray spectrometry

NASA Technical Reports Server (NTRS)

Okelley, G. D.

1975-01-01

Primordial and cosmogenic radionuclide concentrations are determined nondestructively by gamma-ray spectrometry in soil and rock samples from the returned Apollo 17 sample collection from Taurus-Littrow and Descartes. Geochemical evidence in support of field geology speculation concerning layering of the subfloor basalt flows is demonstrated along with a possible correlation of magmatic fractionation of K/U as a function of depth. The pattern of radionuclide concentrations observed in these samples is distinct due to proton bombardment by the intense solar flares of August 4-9, 1972. Such radionuclide determinations are used in determining lunar sample orientation and characterizing solar flare activity.

Monte Carlo Simulation of Spacecraft Particle Detectors to Assess the True Human Risk

NASA Technical Reports Server (NTRS)

O'Neill, Patrick M.

2002-01-01

Particle detectors (DOSTEL, CPDS, and TEPC) measure the energy deposition spectrum inside earth orbiting - manned spacecraft (shuttle, space station). These instruments attempt to emulate the deposition of energy in human tissue to evaluate the health risk. However, the measurements are often difficult to relate to tissue equivalent because nuclear fragmentation (internuclear cascade/evaporation), energy-loss straggling, heavy ions, spacecraft shielding and detector geometry/orientation, and coincidence thresholds significantly affect the measured spectrum. 'A le have developed a high fidelity Monte Carlo model addressing each of these effects that significantly improves interpretation of these instruments and the resulting assessment of radiation risk to humans.

Ultrastructural pathology of cortical capillary pericytes in human traumatic brain oedema.

PubMed

Castejón, Orlando J

2011-01-01

In human traumatic brain oedema pericytes exhibit remarkable oedematous changes, increased vacuolar and vesicular transport, transient transpericytal channels, and tubular structures demonstrating pericyte brain barrier dysfunction. They show nuclear invaginations, actin and myosin-like filaments, and coupled interaction with endothelial cells through the macula occludens. Some pericytes display hypertrophic and necrotic changes, and phagocytic capacity. Hypertrophic pericytes induce basement membrane splitting. Degenerated pericytes exhibit lacunar enlargement of endoplasmic reticulum, dense osmiophilic bodies, glycogen granules, vacuolization, oedematous Golgi apparatus, and pleomorphic mitochondria. Certain micropinocytotic vesicles are orientated to the Golgi complex and multivesicular bodies, suggesting that pericytes play some role in oedema resolution.

Performance testing and analyses of the VSC-17 ventilated concrete cask. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKinnon, M.A.; Dodge, R.E.; Schmitt, R.C.

1992-05-01

This document details performance test which was conducted on a Pacific Sierra Nuclear VSC-17 ventilated concrete storage cask configured for pressurized-water reactor (PWR) spent fuel. The performance test consisted of loading the VSC-17 cask with 17 canisters of consolidated PWR spent fuel from Virginia Power`s Surry and Florida Power & Light Turkey Point reactors. Cask surface, concrete, air channel surfaces, and fuel canister guide tube temperatures were measured, as were cask surface gamma and neutron dose rates. Testing was performed with vacuum, nitrogen, and helium backfill environments in a vertical cask orientation. Data on spent fuel integrity were also obtained.

A complete sample of double-lobed radio quasars for VLBI tests of source models - Definition and statistics

NASA Technical Reports Server (NTRS)

Hough, D. H.; Readhead, A. C. S.

1989-01-01

A complete, flux-density-limited sample of double-lobed radio quasars is defined, with nuclei bright enough to be mapped with the Mark III VLBI system. It is shown that the statistics of linear size, nuclear strength, and curvature are consistent with the assumption of random source orientations and simple relativistic beaming in the nuclei. However, these statistics are also consistent with the effects of interaction between the beams and the surrounding medium. The distribution of jet velocities in the nuclei, as measured with VLBI, will provide a powerful test of physical theories of extragalactic radio sources.

Submersible sodium pump

DOEpatents

Brynsvold, Glen V.; Lopez, John T.; Olich, Eugene E.; West, Calvin W.

1989-01-01

An electromagnetic submerged pump has an outer cylindrical stator with an inner cylindrical conductive core for the submerged pumping of sodium in the cylindrical interstitial volume defined between the stator and core. The cylindrical interstitial volume is typically vertically oriented, and defines an inlet at the bottom and an outlet at the top. The outer stator generates upwardly conveyed toroidal magnetic fields, which fields convey preferably from the bottom of the pump to the top of the pump liquid sodium in the cold leg of a sodium cooled nuclear reactor. The outer cylindrical stator has a vertically disposed duct surrounded by alternately stacked layers of coil units and laminates.

Submersible sodium pump

DOEpatents

Brynsvold, G.V.; Lopez, J.T.; Olich, E.E.; West, C.W.

1989-11-21

An electromagnetic submerged pump has an outer cylindrical stator with an inner cylindrical conductive core for the submerged pumping of sodium in the cylindrical interstitial volume defined between the stator and core. The cylindrical interstitial volume is typically vertically oriented, and defines an inlet at the bottom and an outlet at the top. The outer stator generates upwardly conveyed toroidal magnetic fields, which fields convey preferably from the bottom of the pump to the top of the pump liquid sodium in the cold leg of a sodium cooled nuclear reactor. The outer cylindrical stator has a vertically disposed duct surrounded by alternately stacked layers of coil units and laminates. 14 figs.

The Observed Longitudinal Relationship between Future Orientation and Substance Use Among a Cohort of Youth with Serious Criminal Offenses.

PubMed

Brooks, Merrian; Miller, Elizabeth; Abebe, Kaleab; Mulvey, Edward

2018-03-06

Future orientation (FO), an essential construct in youth development, encompassing goals, expectations for life, and ability to plan for the future. This study uses a multidimensional measure of future orientation to assess the relationship between change in future orientation and change in substance use over time. Data were from the Pathways to Desistence study. Justice involved youth (n = 1,354), ages 14 to 18 at time of recruitment, completed interviews every six months for three years. Multiple measures were chosen a priori as elements of future orientation. After evaluating the psychometrics of a new measure for future orientation, we ran mixed effects cross-lagged panel models to assess the relationship between changes in future orientation and substance use (tobacco, marijuana, hard drugs, and alcohol). There was a significant bidirectional relationship between future orientation and all substance use outcomes. Adjusted models accounted for different sites, sex, age, ethnicity, parental education, and proportion of time spent in a facility. In adjusted models, higher levels of future orientation resulted in smaller increases in substance use at future time points. Future orientation and substance use influence each other in this sample of adolescent offenders. Treating substance use disorders is also likely to increase future orientation, promoting positive youth development more generally. This study expands our understanding of the longitudinal relationship between changes in future orientation and changes in levels of substance use in a sample of justice involved youth with high levels of substance use, a group of considerable clinical and policy interest.

Fathers' Orientation to their Children's Autism Diagnosis: A Grounded Theory Study.

PubMed

Hannon, Michael D; Hannon, LaChan V

2017-07-01

Sixteen fathers of individuals with autism were interviewed to develop a grounded theory explaining how they learned about their children's autism diagnosis. Results suggest the orientation process entails at least two phases: orienting oneself and orienting others. The orienting oneself phase entailed fathers having suspicion of developmental differences, engaging in research and education activities, having their children formally evaluated; inquiring about their children's prognosis, and having curiosities about autism's etiology. The orienting others phase entailed orientating family members and orienting members of their broader communities. Recommendations for responsive service provision, support for fathers, and future research are offered.

Multiple case studies of STEM teachers' orientations to science teaching through engineering design

NASA Astrophysics Data System (ADS)

Rupp, Madeline

The following master's thesis is composed of two manuscripts describing STEM teachers' orientations to science teaching through engineering within the context of the Science Learning through Engineering Design (SLED) partnership. The framework guiding both studies was science teaching orientations, a component of pedagogical content knowledge. Data were collected via semi-structured interviews, multi-day classroom observations, pre- and post-observation interviews, implementation plans, and written reflections. Data sources were analyzed to generate two orientations to science teaching through engineering design for each participant. The first manuscript illustrates a single case study conducted with a sixth grade STEM teacher. Results of this study revealed a detailed picture of the teacher's goals, practices, assessments, and general views when teaching science through engineering design. Common themes across the teacher's instruction were used to characterize her orientations to science teaching through engineering design. Overall, the teacher's orientations showed a shift in her practice from didactic to student-centered methods of teaching as a result of integrating engineering design-based curriculum. The second manuscript describes a comparative case study of two sixth grade SLED participants. Results of this study revealed more complex and diverse relationships between the teachers' orientations to teaching science through engineering design and their instruction. Participants' orientations served as filters for instruction, guided by their divergent purposes for science teaching. Furthermore, their orientations and resulting implementation were developed from knowledge gained in teacher education, implying that teacher educators and researchers can use this framework to learn more about how teachers' knowledge is used to integrate engineering and science practices in the K-12 classroom.

Somatic association of telocentric chromosomes carrying homologous centromeres in common wheat.

PubMed

Mello-Sampayo, T

1973-01-01

Measurements of distances between telocentric chromosomes, either homologous or representing the opposite arms of a metacentric chromosome (complementary telocentrics), were made at metaphase in root tip cells of common wheat carrying two homologous pairs of complementary telocentrics of chromosome 1 B or 6 B (double ditelosomic 1 B or 6 B). The aim was to elucidate the relative locations of the telocentric chromosomes within the cell. The data obtained strongly suggest that all four telocentrics of chromosome 1 B or 6 B are spacially and simultaneously co-associated. In plants carrying two complementary (6 B (S) and 6 B (L)) and a non-related (5 B (L)) telocentric, only the complementary chromosomes were found to be somatically associated. It is thought, therefore, that the somatic association of chromosomes may involve more than two chromosomes in the same association and, since complementary telocentrics are as much associated as homologous, that the homology between centromeres (probably the only homologous region that exists between complementary telocentrics) is a very important condition for somatic association of chromosomes. The spacial arrangement of chromosomes was studied at anaphase and prophase and the polar orientation of chromosomes at prophase was found to resemble anaphase orientation. This was taken as good evidence for the maintenance of the chromosome arrangement - the Rabl orientation - and of the peripheral location of the centromere and its association with the nuclear membrane. Within this general arrangement homologous telocentric chromosomes were frequently seen to have their centromeres associated or directed towards each other. The role of the centromere in somatic association as a spindle fibre attachment and chromosome binder is discussed. It is suggested that for non-homologous chromosomes to become associated in root tips, the only requirement needed should be the homology of centromeres such as exists between complementary telocentrics, or, as a possible alternative, common repeated sequences of DNA molecules around the centromere region.

Unravelling the Influence of Cognitive Style on Chinese Students' Classroom Behaviours: The Mediating Effects of the Structure-Oriented/Depth-Oriented Learning Approach

ERIC Educational Resources Information Center

Cheng, Hong-Yu; Guan, Shu-Yi

2015-01-01

This study was designed to investigate how cognitive style affects Chinese students' learning behaviours in the classroom. A concept labelled as the structure-oriented vs. depth-oriented learning approach was constructed, and its mediating effects in the link between cognitive style and learning behaviour were proposed and examined in this study.…

Curriculum Orientations and Educational Philosophies of High School Arabic Teachers

ERIC Educational Resources Information Center

Alsalem, Abeer Saleh

2018-01-01

This study aims to investigate the curriculum orientations of High school Arabic teacher in Riyadh city and to examine the relationship between curriculum orientation and their educational philosophies. The quantitative method (descriptive study) was adopted in this questionnaire survey-based study. Mean and standard deviation for the overall of…

The dampening effect of employees' future orientation on cyberloafing behaviors: the mediating role of self-control.

PubMed

Zhang, Heyun; Zhao, Huanhuan; Liu, Jingxuan; Xu, Yan; Lu, Hui

2015-01-01

Previous studies on reducing employees' cyberloafing behaviors have primarily examined the external control factors but seldomly taken individual internal subjective factors into consideration. Future orientation, an important individual factor, is defined as the extent to which one plans for future time and considers future consequences of one's current behavior. To explore further whether and how employees' future orientation can dampen their cyberloafing behaviors, two studies were conducted to examine the relationship between employees' future orientation and cyberloafing behaviors. The mediation effect of employees' objective and subjective self-control between them was also examined. In Study 1, a set of questionnaires was completed, and the results revealed that the relationship between employees' future orientation and cyberloafing behaviors was negative, and objective self-control mediated the relationship. Next, we conducted a priming experiment (Study 2) to examine the causal relationship and psychological mechanism between employees' future orientation and cyberloafing behaviors. The results demonstrated that employees' future-orientation dampened their attitudes and intentions to engage in cyberloafing, and subjective self-control mediated this dampening effect. Theoretical and practical implications of these findings are also discussed.

Study of relationship between the organizational structure and market orientation from the viewpoint of nurse managers.

PubMed

Bahadori, Mohammadkarim; Yaghoubi, Maryam; Javadi, Marzieh; Rahimi, Zahreh Agha

2015-01-01

Considering globalization of health care and quality improvement trend to respond to competition and customer orientation, attention to organizational structure and its relationship with market orientation is essential. Therefore, this study reviews the relationship between organizational structure and market orientation in selected hospitals of Isfahan (Iran). This study was a descriptive survey. The study population comprised nurse managers from selected hospitals (n = 80). Data collection tools were two questionnaires (market orientation questionnaire and organizational structure) that the validity and reliability were confirmed (r = 0.83 for market orientation questionnaire and r = 0.87 for organizational structure). SPSS (Ver. 16) software was used for the analyses. The mean score of organizational structure was 65.4 (11.2) and total mean of market orientation was 51.14 (17.6). All aspects of the organizational structure (Organization Centralization, Formalization in Organization, and Organization Complication) and market orientation (responding to competition, accountability, customer satisfaction, intelligent organization)-except by responding to clients with Formalization in Organization-as well as all aspects of the Systemic attitude (the system of internal coordination and communication systems_ and market orientation (responding to competition, accountability, customer satisfaction, intelligent organization), there was a meaningful relationship (P < 0.05). Market orientation and its dimensions have a significant relationship with organizational structure and can lead managers' view to the analysis and recognizing elements of success and achievement to goals. With increasing competition in markets, globalization of health services, and presence in international markets and more attention to patients' satisfaction, hospitals need to understand and use of market orientation in order to promote quality and services in the health care system.

Study of relationship between the organizational structure and market orientation from the viewpoint of nurse managers

PubMed Central

Bahadori, Mohammadkarim; Yaghoubi, Maryam; Javadi, Marzieh; Rahimi, Zahreh Agha

2015-01-01

Background: Considering globalization of health care and quality improvement trend to respond to competition and customer orientation, attention to organizational structure and its relationship with market orientation is essential. Therefore, this study reviews the relationship between organizational structure and market orientation in selected hospitals of Isfahan (Iran). Materials and Methods: This study was a descriptive survey. The study population comprised nurse managers from selected hospitals (n = 80). Data collection tools were two questionnaires (market orientation questionnaire and organizational structure) that the validity and reliability were confirmed (r = 0.83 for market orientation questionnaire and r = 0.87 for organizational structure). SPSS (Ver. 16) software was used for the analyses. Results: The mean score of organizational structure was 65.4 (11.2) and total mean of market orientation was 51.14 (17.6). All aspects of the organizational structure (Organization Centralization, Formalization in Organization, and Organization Complication) and market orientation (responding to competition, accountability, customer satisfaction, intelligent organization)—except by responding to clients with Formalization in Organization—as well as all aspects of the Systemic attitude (the system of internal coordination and communication systems_ and market orientation (responding to competition, accountability, customer satisfaction, intelligent organization), there was a meaningful relationship (P < 0.05). Conclusion: Market orientation and its dimensions have a significant relationship with organizational structure and can lead managers’ view to the analysis and recognizing elements of success and achievement to goals. With increasing competition in markets, globalization of health services, and presence in international markets and more attention to patients’ satisfaction, hospitals need to understand and use of market orientation in order to promote quality and services in the health care system. PMID:25861660

Fantasy Orientation Constructs and Related Executive Function Development in Preschool: Developmental Benefits to Executive Functions by Being a Fantasy-Oriented Child

ERIC Educational Resources Information Center

Pierucci, Jillian M.; O'Brien, Christopher T.; McInnis, Melissa A.; Gilpin, Ansley Tullos; Barber, Angela B.

2014-01-01

This study explored unique constructs of fantasy orientation and whether there are developmental benefits for fantasy-oriented children. By age 3, children begin developing executive functions, with some children exhibiting high fantasy orientation in their cognitions and behaviors. Preschoolers ("n" = 106) completed fantasy orientation…

Preliminary results of radiation measurements on EURECA

NASA Technical Reports Server (NTRS)

Benton, E. V.; Frank, A. L.

1995-01-01

The eleven-month duration of the EURECA mission allows long-term radiation effects to be studied similarly to those of the Long Duration Exposure Facility (LDEF). Basic data can be generated for projections to crew doses and electronic and computer reliability on spacecraft missions. A radiation experiment has been designed for EURECA which uses passive integrating detectors to measure average radiation levels. The components include a Trackoscope, which employs fourteen plastic nuclear track detector (PNTD) stacks to measure the angular dependence of high LET (greater than or equal to 6 keV/micro m) radiation. Also included are TLD's for total absorbed doses, thermal/resonance neutron detectors (TRND's) for low energy neutron fluences and a thick PNTD stack for depth dependence measurements. LET spectra are derived from the PNTD measurements. Preliminary TLD results from seven levels within the detector array show that integrated does inside the flight canister varied from 18.8 +/- 0.6 cGy to 38.9 +/- 1.2 cGy. The TLD's oriented toward the least shielded direction averaged 53% higher in dose than those oriented away from the least shielded direction (minimum shielding toward the least shielded direction varied from 1.13 to 7.9 g/cm(exp 2), Al equivalent). The maximum dose rate on EURECA (1.16 mGy/day) was 37% of the maximum measured on LDEF and dose rates at all depths were less than measured on LDEF. The shielding external to the flight canister covered a greater solid angle about the canister than the LDEF experiments.

Is medical students' moral orientation changeable after preclinical medical education?

PubMed

Lin, Chaou-Shune; Tsou, Kuo-Inn; Cho, Shu-Ling; Hsieh, Ming-Shium; Wu, Hsi-Chin; Lin, Chyi-Her

2012-03-01

Moral orientation can affect ethical decision-making. Very few studies have focused on whether medical education can change the moral orientation of the students. The purpose of the present study was to document the types of moral orientation exhibited by medical students, and to study if their moral orientation was changed after preclinical education. From 2007 to 2009, the Mojac scale was used to measure the moral orientation of Taiwan medical students. The students included 271 first-year and 109 third-year students. They were rated as a communitarian, dual, or libertarian group and followed for 2 years to monitor the changes in their Mojac scores. In both first and third-year students, the dual group after 2 years of preclinical medical education did not show any significant change. In the libertarian group, first and third-year students showed a statistically significant increase from a score of 99.4 and 101.3 to 103.0 and 105.7, respectively. In the communitarian group, first and third-year students showed a significant decline from 122.8 and 126.1 to 116.0 and 121.5, respectively. During the preclinical medical education years, students with communitarian orientation and libertarian orientation had changed in their moral orientation to become closer to dual orientation. These findings provide valuable hints to medical educators regarding bioethics education and the selection criteria of medical students for admission.

AGN fuelling: Bridging Large and Small Scales - Overlapping Inflows as Catalysts of Accretion

NASA Astrophysics Data System (ADS)

Manuel Carmona Loaiza, Juan Manuel

2015-05-01

One of the biggest challenges in understanding the fuelling of supermassive black holes in active galactic nuclei (AGN) is not on accounting for the source of fuel, as a galaxy can comfortably supply the required mass budget, but on its actual delivery. While a clear picture has been developed for the large scale (~ kpc) down to the intermediate one (~ 100 pc), and for the smallest scales (~ 0.1 pc) where an accretion disc likely forms, a bridge that has proven difficult to build is that between ~ 100 pc and ~ 0.1 pc. It is feared that gas at these scales might still retain enough angular momentum and settle into a larger scale disc with very low or no inflow to form or replenish the inner accretion disc (on ~ 0.01 pc scales). In this Thesis, I present numerical simulations in which a rotating gaseous shell flows towards a SMBH because of its lack of rotational support. As inflow proceeds, gas from the shell impacts an already present nuclear (~ 10pc) disc. The cancellation of angular momentum and redistribution of gas, due to the misalignment between the angular momentum of the shell and that of the disc, is studied in this scenario. The underlying hypothesis is that even if transport of angular momentum at these scales may be inefficient, the interaction of an inflow with a nuclear disc would still provide a mechanism to bring mass inwards because of the cancellation of angular momentum. I quantify the amount of gas such a cancellation would bring to the central parsec under different circumstances: Co- and counter-rotation between the disc and the shell and the presence or absence of an initial turbulent kick; I also discuss the impact of self gravity in our simulations. The scenario we study is highly idealized and designed to capture the specific outcomes produced by the mechanism proposed. I find that angular momentum cancellation and redistribution via hydrodynamical shocks leads to sub-pc inflows enhanced by more than 2-3 orders of magnitude. In all of our simulations, the gas inflow rate across the inner parsec is higher than in the absence of the interaction. Gas mixing changes the orientation of the nuclear disc as the interaction proceeds until warped discs or nested misaligned rings form as relic structures. The amount of inflow depends mainly on the spin orientation of the shell relative to the disc, while the relic warped disc structure depends mostly on the turbulent kick given to the gaseous shell in the initial conditions. The main conclusion of this Thesis is that actual cancellation of angular momentum within galactic nuclei can have a significant impact on feeding super massive black holes. Such cancellation by inflow-disc interactions would leave warped 10 - 20 pc discs as remnants.

Labour-Market Orientation and Approaches to Studying--A Study of the First "Bologna Students" at a Swedish Regional University

ERIC Educational Resources Information Center

Nelson, Anders; Sandberg, Mikael

2017-01-01

This study investigated labour-market orientations of students at a Swedish University with a dual/diverse focus on vocational/academic objectives. The aim was to investigate whether and how levels of students' labour-market orientation vary with social background, change during the study period, and are related to approaches to studying and…

Acoustic correlates of sexual orientation and gender-role self-concept in women's speech.

PubMed

Kachel, Sven; Simpson, Adrian P; Steffens, Melanie C

2017-06-01

Compared to studies of male speakers, relatively few studies have investigated acoustic correlates of sexual orientation in women. The present investigation focuses on shedding more light on intra-group variability in lesbians and straight women by using a fine-grained analysis of sexual orientation and collecting data on psychological characteristics (e.g., gender-role self-concept). For a large-scale women's sample (overall n = 108), recordings of spontaneous and read speech were analyzed for median fundamental frequency and acoustic vowel space features. Two studies showed no acoustic differences between lesbians and straight women, but there was evidence of acoustic differences within sexual orientation groups. Intra-group variability in median f0 was found to depend on the exclusivity of sexual orientation; F1 and F2 in /iː/ (study 1) and median f0 (study 2) were acoustic correlates of gender-role self-concept, at least for lesbians. Other psychological characteristics (e.g., sexual orientation of female friends) were also reflected in lesbians' speech. Findings suggest that acoustic features indexicalizing sexual orientation can only be successfully interpreted in combination with a fine-grained analysis of psychological characteristics.

Reciprocal relationships between value orientation and motivational interference during studying and leisure.

PubMed

Hofer, Manfred; Schmid, Sebastian; Fries, Stefan; Kilian, Britta; Kuhnle, Claudia

2010-12-01

Motivational interference is defined as the amount of impairment in a target activity due to the incentives of a non-chosen attractive alternative. The amount to which pupils experience motivational interference while studying or while performing a leisure activity in a school-leisure conflict situation is seen as depending on the values they attach to achievement and well-being. At the same time, values may also be effects of frequent experience of motivational interference in the respective areas. The study is aimed at investigating the reciprocal relationship between personal value orientations and the experience of motivational interference during studying and leisure. A total of 363 pupils (sixth to eighth graders at the time of first measurement) completed the same questionnaire twice in a 2-year interval. The questionnaire included measures of achievement and well-being value orientation and the experience of motivational interference during studying and during leisure in school-leisure conflicts. For this, two scenarios were created. In regression analyses, achievement and well-being value orientations as well as their interaction terms were used as predictors for experience of motivational interference at t(2) while controlling for experience of motivational interference at t(1), and vice versa. Additionally in path models, these relations were tested in an integrative way. Pupils' achievement value orientations were connected to differential changes in experiencing motivational interference during leisure and during studying in one scenario but only for pupils low or medium in well-being value orientation. Conversely, experience of motivational interference at t(1) was related to changes in value orientations 2 years later. High motivational interference during studying led to an increase in well-being value orientation, while high motivational interference during leisure was followed by a decrease in well-being value orientation and an increase in achievement value orientation. Overall, path models supported these results. The results are discussed in terms of value change and are linked to self-control and motivation research.

Investigation of Li/Nb-sublattices in ion implanted LiNbO3 by RBS and NRA in channelling configuration

NASA Astrophysics Data System (ADS)

Schmidt, E.; Ritter, K.; Gärtner, K.; Wendler, E.

2017-10-01

Differently oriented LiNbO3 crystals were implanted at room temperature with 1 MeV iodine ions to fluences between 2 × 1013 and 1 × 1014 cm-2, which cover the transition from a low damage level up to complete amorphisation. The aim of this work was to explore the use of nuclear reaction analysis (NRA) in combination with Rutherford backscattering spectrometry (RBS) in channelling configuration for studying the damage evolution as a function of the ion fluence in both the Li and Nb sublattice. Protons with energies between 1.4 and 1.6 MeV and a standard RBS setup were used. Scattering events detected at low energies result from Rutherford backscattering of protons on Nb and O atoms. At high energies alpha particles are registered, which result from the nuclear reaction between protons and Li atoms. Along different low-index crystallographic directions channelling effects within both the RBS and NRA part of the spectra are observed. However, the strength of channeling within the NRA part depends on the crystallographic direction investigated. These effects are explained by the nature of ion-channelling with respect to the small atomic number of Li and is supported by calculations of minimum yields (ratio of scattering yield in aligned and random direction) applying the computer code DICADA. The consequence is that damage studies with NRA can be only performed in Z-direction of LiNbO3. In this case, the Li and Nb sublattice were found to be similarly damaged after 1 MeV iodine implantation.

Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO).

PubMed

Alborghetti, Marcos Rodrigo; Furlan, Ariane da Silva; da Silva, Júlio César; Sforça, Maurício Luís; Honorato, Rodrigo Vargas; Granato, Daniela Campos; dos Santos Migueleti, Deivid Lucas; Neves, Jorge L; de Oliveira, Paulo Sergio Lopes; Paes-Leme, Adriana Franco; Zeri, Ana Carolina de Mattos; de Torriani, Iris Concepcion Linares; Kobarg, Jörg

2013-01-01

Cytoskeleton and protein trafficking processes, including vesicle transport to synapses, are key processes in neuronal differentiation and axon outgrowth. The human protein FEZ1 (fasciculation and elongation protein zeta 1 / UNC-76, in C. elegans), SCOCO (short coiled-coil protein / UNC-69) and kinesins (e.g. kinesin heavy chain / UNC116) are involved in these processes. Exploiting the feature of FEZ1 protein as a bivalent adapter of transport mediated by kinesins and FEZ1 protein interaction with SCOCO (proteins involved in the same path of axonal growth), we investigated the structural aspects of intermolecular interactions involved in this complex formation by NMR (Nuclear Magnetic Resonance), cross-linking coupled with mass spectrometry (MS), SAXS (Small Angle X-ray Scattering) and molecular modelling. The topology of homodimerization was accessed through NMR (Nuclear Magnetic Resonance) studies of the region involved in this process, corresponding to FEZ1 (92-194). Through studies involving the protein in its monomeric configuration (reduced) and dimeric state, we propose that homodimerization occurs with FEZ1 chains oriented in an anti-parallel topology. We demonstrate that the interaction interface of FEZ1 and SCOCO defined by MS and computational modelling is in accordance with that previously demonstrated for UNC-76 and UNC-69. SAXS and literature data support a heterotetrameric complex model. These data provide details about the interaction interfaces probably involved in the transport machinery assembly and open perspectives to understand and interfere in this assembly and its involvement in neuronal differentiation and axon outgrowth.

Structural Analysis of Intermolecular Interactions in the Kinesin Adaptor Complex Fasciculation and Elongation Protein Zeta 1/ Short Coiled-Coil Protein (FEZ1/SCOCO)

PubMed Central

da Silva, Júlio César; Sforça, Maurício Luís; Honorato, Rodrigo Vargas; Granato, Daniela Campos; dos Santos Migueleti, Deivid Lucas; Neves, Jorge L.; de Oliveira, Paulo Sergio Lopes; Paes-Leme, Adriana Franco; Zeri, Ana Carolina de Mattos; de Torriani, Iris Concepcion Linares; Kobarg, Jörg

2013-01-01

Cytoskeleton and protein trafficking processes, including vesicle transport to synapses, are key processes in neuronal differentiation and axon outgrowth. The human protein FEZ1 (fasciculation and elongation protein zeta 1 / UNC-76, in C. elegans), SCOCO (short coiled-coil protein / UNC-69) and kinesins (e.g. kinesin heavy chain / UNC116) are involved in these processes. Exploiting the feature of FEZ1 protein as a bivalent adapter of transport mediated by kinesins and FEZ1 protein interaction with SCOCO (proteins involved in the same path of axonal growth), we investigated the structural aspects of intermolecular interactions involved in this complex formation by NMR (Nuclear Magnetic Resonance), cross-linking coupled with mass spectrometry (MS), SAXS (Small Angle X-ray Scattering) and molecular modelling. The topology of homodimerization was accessed through NMR (Nuclear Magnetic Resonance) studies of the region involved in this process, corresponding to FEZ1 (92-194). Through studies involving the protein in its monomeric configuration (reduced) and dimeric state, we propose that homodimerization occurs with FEZ1 chains oriented in an anti-parallel topology. We demonstrate that the interaction interface of FEZ1 and SCOCO defined by MS and computational modelling is in accordance with that previously demonstrated for UNC-76 and UNC-69. SAXS and literature data support a heterotetrameric complex model. These data provide details about the interaction interfaces probably involved in the transport machinery assembly and open perspectives to understand and interfere in this assembly and its involvement in neuronal differentiation and axon outgrowth. PMID:24116125

Effects of Process-Oriented and Product-Oriented Worked Examples and Prior Knowledge on Learner Problem Solving and Attitude: A Study in the Domain of Microeconomics

ERIC Educational Resources Information Center

Brooks, Christopher Darren

2009-01-01

The purpose of this study was to investigate the effectiveness of process-oriented and product-oriented worked example strategies and the mediating effect of prior knowledge (high versus low) on problem solving and learner attitude in the domain of microeconomics. In addition, the effect of these variables on learning efficiency as well as the…

Supply chain dynamics in healthcare services.

PubMed

Samuel, Cherian; Gonapa, Kasiviswanadh; Chaudhary, P K; Mishra, Ananya

2010-01-01

The purpose of this paper is to analyse health service supply chain systems. A great deal of literature is available on supply chain management in finished goods inventory situations; however, little research exists on managing service capacity when finished goods inventories are absent. System dynamics models for a typical service-oriented supply chain such as healthcare processes are developed, wherein three service stages are presented sequentially. Just like supply chains with finished goods inventory, healthcare service supply chains also show dynamic behaviour. Comparing options, service reduction, and capacity adjustment delays showed that reducing capacity adjustment and service delays gives better results. The study is confined to health service-oriented supply chains. Further work includes extending the study to service-oriented supply chains with parallel processing, i.e. having more than one stage to perform a similar operation and also to study the behaviour in service-oriented supply chains that have re-entrant orders and applications. Specific case studies can also be developed to reveal factors relevant to particular service-oriented supply chains. The paper explains the bullwhip effect in healthcare service-oriented supply chains. Reducing stages and capacity adjustment are strategic options for service-oriented supply chains. The paper throws light on policy options for managing healthcare service-oriented supply chain dynamics.

The relationship between operative and radiographic acetabular component orientation: which factors influence resultant cup orientation?

PubMed

Grammatopoulos, G; Pandit, H G; da Assunção, R; McLardy-Smith, P; De Smet, K A; Gill, H S; Murray, D W

2014-10-01

There is great variability in acetabular component orientation following hip replacement. The aims of this study were to compare the component orientation at impaction with the orientation measured on post-operative radiographs and identify factors that influence the difference between the two. A total of 67 hip replacements (52 total hip replacements and 15 hip resurfacings) were prospectively studied. Intra-operatively, the orientation of the acetabular component after impaction relative to the operating table was measured using a validated stereo-photogrammetry protocol. Post-operatively, the radiographic orientation was measured; the mean inclination/anteversion was 43° (sd 6°)/ 19° (sd 7°). A simulated radiographic orientation was calculated based on how the orientation would have appeared had an on-table radiograph been taken intra-operatively. The mean difference between radiographic and intra-operative inclination/anteversion was 5° (sd 5°)/ -8° (sd 8°). The mean difference between simulated radiographic and intra-operative inclination/anteversion, which quantifies the effect of the different way acetabular orientation is measured, was 3°/-6° (sd 2°). The mean difference between radiographic and simulated radiographic orientation inclination/anteversion, which is a manifestation of the change in pelvic position between component impaction and radiograph, was 1°/-2° (sd 7°). This study demonstrated that in order to achieve a specific radiographic orientation target, surgeons should implant the acetabular component 5° less inclined and 8° more anteverted than their target. Great variability (2 sd about ± 15°) in the post-operative radiographic cup orientation was seen. The two equally contributing causes for this are variability in the orientation at which the cup is implanted, and the change in pelvic position between impaction and post-operative radiograph. ©2014 The British Editorial Society of Bone & Joint Surgery.

Russian University Education in Nuclear Safeguards and Security

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, Cristen L.; Kryuchkov, Eduard F.; Geraskin, Nikolay I.

2009-03-15

As safeguards and security (S&S) systems are installed and upgraded in nuclear facilities throughout Russia, it becomes increasingly important to develop mechanisms for educating future Russian nuclear scientists and engineers in the technologies and methodologies of physical protection (PP) and nuclear material control and accounting (MC&A). As part of the U.S. Department of Energy’s (DOE) program to secure nuclear materials in Russia, the Education Project supports technical S&S degree programs at key Russian universities and nonproliferation education initiatives throughout the Russian Federation that are necessary to achieve the overall objective of fostering qualified and vigilant Russian S&S personnel. The Educationmore » Project supports major educational degree programs at the Moscow Engineering Physics Institute (MEPhI) and Tomsk Polytechnic University (TPU). The S&S Graduate Program is available only at MEPhI and is the world’s first S&S degree program. Ten classes of students have graduated with a total of 79 Masters Degrees as of early 2009. At least 84% of the graduates over the ten years are still working in the S&S field. Most work at government agencies or research organizations, and some are pursuing their PhD. A 5½ year Engineering Degree Program (EDP) in S&S is currently under development at MEPhI and TPU. The EDP is more tailored to the needs of nuclear facilities. The program’s first students (14) graduated from MEPhI in February 2007. Similar-sized classes are graduating from MEPhI each February. All of the EDP graduates are working in the S&S field, many at nuclear facilities. TPU also established an EDP and graduated its first class of approximately 18 students in February 2009. For each of these degree programs, the American project team works with MEPhI and TPU to develop appropriate curriculum, identify and acquire various training aids, develop and publish textbooks, and strengthen instructor skills. The project has also supported the instruction of policy-oriented nonproliferation courses at various Russian universities. These courses are targeted towards future workers in the nuclear field to help build an effective nonproliferation awareness within the nuclear complex. A long-range goal of this project is to assist the educational programs at MEPhI and TPU in becoming self-sustainable and therefore able to maintain the three degree programs without DOE support. This paper describes current development of these education programs and new initiatives. The paper also describes general nonproliferation education activities supported by DOE that complement the more technical S&S degree programs.« less

The relationship between religious orientation, and gender with a cognitive distortion.

PubMed

Amirsardari, Leili; Azari, Shafie; Esmali Kooraneh, Ahmad

2014-01-01

The objective of this study was to determine the relationship between religious orientation (intrinsic-external) and cognitive distortions. General design of this study considered as a descriptive and correlational method. Universal population in this research consist all students of the Urmia Azad University, which were studying during 2012 and 2013 (n = 250). All respondents filled the Alports religious and cognitive distortions questionnaires. The answers were analyzed with step by step regression and correlation method. The research showed a significant relationship between the religious orientation and cognitive distortions (p < 0.005) (p < 0.001). The results suggest that religious orientation is an important factor in cognitive distortions and individuals with intrinsic religious orientation have less cognitive distortion.

Use of multiscale zirconium alloy deformation models in nuclear fuel behavior analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montgomery, Robert; Tomé, Carlos; Liu, Wenfeng

Accurate prediction of cladding mechanical behavior is a key aspect of modeling nuclear fuel behavior, especially for conditions of pellet-cladding interaction (PCI), reactivity-initiated accidents (RIA), and loss of coolant accidents (LOCA). Current approaches to fuel performance modeling rely on empirical models for cladding creep, growth and plastic deformation, which are limited to the materials and conditions for which the models were developed. CASL has endeavored to improve upon this approach by incorporating a microstructurally-based, atomistically-informed, zirconium alloy mechanical deformation analysis capability into the BISON-CASL engineering scale fuel performance code. Specifically, the viscoplastic self-consistent (VPSC) polycrystal plasticity modeling approach, developed bymore » Lebensohn and Tome´ [2], has been coupled with BISON-CASL to represent the mechanistic material processes controlling the deformation behavior of the cladding. A critical component of VPSC is the representation of the crystallographic orientation of the grains within the matrix material and the ability to account for the role of texture on deformation. The multiscale modeling of cladding deformation mechanisms allowed by VPSC far exceed the functionality of typical semi-empirical constitutive models employed in nuclear fuel behavior codes to model irradiation growth and creep, thermal creep, or plasticity. This paper describes the implementation of an interface between VPSC and BISON-CASL and provides initial results utilizing the coupled functionality.« less

A new oxidation based technique for artifact free TEM specimen preparation of nuclear graphite

NASA Astrophysics Data System (ADS)

Johns, Steve; Shin, Wontak; Kane, Joshua J.; Windes, William E.; Ubic, Rick; Karthik, Chinnathambi

2018-07-01

Graphite is a key component in designs of current and future nuclear reactors whose in-service lifetimes are dependent upon the mechanical performance of the graphite. Irradiation damage from fast neutrons creates lattice defects which have a dynamic effect on the microstructure and mechanical properties of graphite. Transmission electron microscopy (TEM) can offer real-time monitoring of the dynamic atomic-level response of graphite subjected to irradiation; however, conventional TEM specimen-preparation techniques, such as argon ion milling itself, damage the graphite specimen and introduce lattice defects. It is impossible to distinguish these defects from the ones created by electron or neutron irradiation. To ensure that TEM specimens are artifact-free, a new oxidation-based technique has been developed. Bulk nuclear grades of graphite (IG-110 and NBG-18) and highly oriented pyrolytic graphite (HOPG) were initially mechanically thinned to ∼60 μm. Discs 3 mm in diameter were then oxidized at temperatures between 575 °C and 625 °C in oxidizing gasses using a new jet-polisher-like set-up in order to achieve optimal oxidation conditions to create self-supporting electron-transparent TEM specimens. The quality of these oxidized specimens were established using optical and electron microscopy. Samples oxidized at 575 °C exhibited large areas of electron transparency and the corresponding lattice imaging showed no apparent damage to the graphite lattice.

A new oxidation based technique for artifact free TEM specimen preparation of nuclear graphite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johns, Steve; Shin, Wontak; Kane, Joshua J.

Graphite is a key component in designs of current and future nuclear reactors whose in-service lifetimes are dependent upon the mechanical performance of the graphite. Irradiation damage from fast neutrons creates lattice defects which have a dynamic effect on the microstructure and mechanical properties of graphite. Transmission electron microscopy (TEM) can offer real-time monitoring of the dynamic atomic-level response of graphite subjected to irradiation; however, conventional TEM specimen-preparation techniques, such as argon ion milling itself, damage the graphite specimen and introduce lattice defects. It is impossible to distinguish these defects from the ones created by electron or neutron irradiation. Thus,tomore » ensure that TEM specimens are artifact-free, a new oxidation-based technique has been developed. Bulk nuclear grades of graphite (IG-110 and NBG-18) and highly oriented pyrolytic graphite (HOPG) were initially mechanically thinned to ~60μm. Discs 3mm in diameter were then oxidized at temperatures between 575°C and 625°C in oxidizing gasses using a new jet-polisher-like set-up in order to achieve optimal oxidation conditions to create self-supporting electron-transparent TEM specimens. The quality of these oxidized specimens were established using optical and electron microscopy. Samples oxidized at 575°C exhibited large areas of electron transparency and the corresponding lattice imaging showed no apparent damage to the graphite lattice.« less

Dendrobium moniliforme Exerts Inhibitory Effects on Both Receptor Activator of Nuclear Factor Kappa-B Ligand-Mediated Osteoclast Differentiation in Vitro and Lipopolysaccharide-Induced Bone Erosion in Vivo.

PubMed

Baek, Jong Min; Kim, Ju-Young; Ahn, Sung-Jun; Cheon, Yoon-Hee; Yang, Miyoung; Oh, Jaemin; Choi, Min Kyu

2016-03-01

Dendrobium moniliforme (DM) is a well-known plant-derived extract that is widely used in Oriental medicine. DM and its chemical constituents have been reported to have a variety of pharmacological effects, including anti-oxidative, anti-inflammatory, and anti-tumor activities; however, no reports discuss the beneficial effects of DM on bone diseases such as osteoporosis. Thus, we investigated the relationship between DM and osteoclasts, cells that function in bone resorption. We found that DM significantly reduced receptor activator of nuclear factor kappa-B ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP)-positive osteoclast formation; DM directly induced the down-regulation of c-Fos and nuclear factor of activated T cells c1 (NFATc1) without affecting other RANKL-dependent transduction pathways. In the later stages of osteoclast maturation, DM negatively regulated the organization of filamentous actin (F-actin), resulting in impaired bone-resorbing activity by the mature osteoclasts. In addition, micro-computed tomography (μ-CT) analysis of the murine model revealed that DM had a beneficial effect on lipopolysaccharide (LPS)-mediated bone erosion. Histological analysis showed that DM attenuated the degradation of trabecular bone matrix and formation of TRAP-positive osteoclasts in bone tissues. These results suggest that DM is a potential candidate for the treatment of metabolic bone disorders such as osteoporosis.

A new oxidation based technique for artifact free TEM specimen preparation of nuclear graphite

DOE PAGES

Johns, Steve; Shin, Wontak; Kane, Joshua J.; ...

2018-04-03

Graphite is a key component in designs of current and future nuclear reactors whose in-service lifetimes are dependent upon the mechanical performance of the graphite. Irradiation damage from fast neutrons creates lattice defects which have a dynamic effect on the microstructure and mechanical properties of graphite. Transmission electron microscopy (TEM) can offer real-time monitoring of the dynamic atomic-level response of graphite subjected to irradiation; however, conventional TEM specimen-preparation techniques, such as argon ion milling itself, damage the graphite specimen and introduce lattice defects. It is impossible to distinguish these defects from the ones created by electron or neutron irradiation. Thus,tomore » ensure that TEM specimens are artifact-free, a new oxidation-based technique has been developed. Bulk nuclear grades of graphite (IG-110 and NBG-18) and highly oriented pyrolytic graphite (HOPG) were initially mechanically thinned to ~60μm. Discs 3mm in diameter were then oxidized at temperatures between 575°C and 625°C in oxidizing gasses using a new jet-polisher-like set-up in order to achieve optimal oxidation conditions to create self-supporting electron-transparent TEM specimens. The quality of these oxidized specimens were established using optical and electron microscopy. Samples oxidized at 575°C exhibited large areas of electron transparency and the corresponding lattice imaging showed no apparent damage to the graphite lattice.« less

Structural and Hydrologic Implications of Joint Orientations in the Warner Creek and Stony Clove Drainage Basins, Catskill Mountains, Eastern New York

NASA Astrophysics Data System (ADS)

Haskins, M. N.; Vollmer, F. W.; Rayburn, J. A.; Gurdak, J. J.

2010-12-01

To investigate joint control on hydrology as well as tectonic implications, we conducted a study of joint orientations near the Stony Clove and Warner Creek drainages of the Catskill Mountains, Eastern New York. Specific goals of this research were to determine joint control on stream orientations and groundwater flow, to compare results with previous studies in the area, and to investigate their tectonic significance. Trails, streams, and road cuts were traversed to locate bedrock outcrops whose positions were determined using topographic maps and a handheld GPS unit. Additional outcrops were located using aerial photographs and GIS data. Joint orientations were measured using a standard Brunton pocket transit. The data was analyzed using Orient (Vollmer, 2010), an orientation analysis program, to plot joint and stream orientations on rose diagrams. ArcGIS was used to produce topographic, hill-shade, and stream drainage maps. Over 500 joint orientations at over 100 outcrop stations were collected. The data were plotted on a rose diagrams, and two major joint sets were found, one with a mean strike of 021° and one with a mean strike of 096°. Stream orientations were also plotted on a rose diagram showing an axial mean of 022°, and indicate that the joint set with mean strike of 021 may have a significant control on stream orientations. The hill-shade maps also demonstrate clearly the strong control of jointing on the topography. The data collected in this research expands on previous joint orientation studies of Engelder and Geiser (1980) in the southwestern and central Catskills, and is similar to joint orientations found by Isachsen et al. (1977) in their study of the Panther Mountain circular structure, a possible impact-related feature. The origin of this jointing is thought to be related to Alleghanian (Permian) and possibly Acadian (Devonian) orogenic events.

Facing Off: Comparing an In-Person Library Orientation Lecture with an Asynchronous Online Library Orientation

ERIC Educational Resources Information Center

Gall, Dan

2014-01-01

A study to compare the effectiveness of an in-person library orientation with an online asynchronous orientation was conducted with three sections of Social Work Research Methods, a required course in the University of Iowa's Master of Social Work program. Two sections of the course received an online orientation involving short videos, text and…

Orientation of Zn3P2 films via phosphidation of Zn precursors

NASA Astrophysics Data System (ADS)

Katsube, Ryoji; Nose, Yoshitaro

2017-02-01

Orientation of solar absorber is an important factor to achieve high efficiency of thin film solar cells. In the case of Zn3P2 which is a promising absorber of low-cost and high-efficiency solar cells, (110)/(001) orientation was only reported in previous studies. We have successfully prepared (101)-oriented Zn3P2 films by phosphidation of (0001)-oriented Zn films at 350 °C. The phosphidation mechanism of Zn is discussed through STEM observations on the partially-reacted sample and the consideration of the relationship between the crystal structures of Zn and Zn3P2 . We revealed that (0001)-oriented Zn led to nucleation of (101)-oriented Zn3P2 due to the similarity in atomic arrangement between Zn and Zn3P2 . The electrical resistivity of the (101)-oriented Zn3P2 film was lower than those of (110)/(001)-oriented films, which is an advantage of the phosphidation technique to the growth processes in previous works. The results in this study demonstrated that well-conductive Zn3P2 films could be obtained by controlling orientations of crystal grains, and provide a guiding principle for microstructure control in absorber materials.

Therapeutic orientations, professional efficacy, and burnout among substance abuse social workers in Israel.

PubMed

Tartakovsky, Eugene; Kovardinsky, Slava

2013-07-01

This study investigates the therapeutic orientations of substance abuse social workers and the relationship between these orientations and burnout. Ninety-two social workers who provided outpatient treatment to people suffering from substance-related disorders in Israel participated in the study. The results obtained demonstrated that the substance abuse social workers adhere more to the psychodynamic and ecosystemic therapeutic orientations than to the cognitive-behavioral orientation. A greater adherence to the cognitive-behavioral orientation was associated with a higher sense of professional efficacy; a greater adherence to the psychodynamic orientation was associated with a higher level of exhaustion; and greater adherence to the ecosystemic orientation was associated with lower levels of exhaustion and cynicism. Female social workers reported lower levels of exhaustion and cynicism. The cognitive-behavioral orientation mediated the connection between the social workers' experience in the field of substance abuse and two dimensions of burnout-exhaustion and professional efficacy. Significance of the findings for improving the well-being of substance abuse social workers and for the advancement of psychosocial services is discussed. Copyright © 2013 Elsevier Inc. All rights reserved.

"Think" versus "feel" framing effects in persuasion.

PubMed

Mayer, Nicole D; Tormala, Zakary L

2010-04-01

Three studies explored think ("I think . . . ") versus feel ("I feel . . . ") message framing effects on persuasion.The authors propose a matching hypothesis, suggesting that think framing will be more persuasive when the target attitude or message recipient is cognitively oriented, whereas feel framing will be more persuasive when the target attitude or message recipient is affectively oriented. Study 1 presented cognitively and affectively oriented individuals with a think- or feel-framed message. Study 2 primed cognitive or affective orientation and then presented a think- or feel-framed message. Study 3 presented male and female participants with an advertisement containing think- or feel-framed arguments. Results indicated that think (feel) framing was more persuasive when the target attitude or recipient was cognitively (affectively) oriented. Moreover, Study 2 demonstrated that this matching effect was mediated by processing fluency. Theoretical and practical implications are discussed.

The role of radionuclide imaging in the surgical management of primary hyperparathyroidism.

PubMed

Hindié, Elif; Zanotti-Fregonara, Paolo; Tabarin, Antoine; Rubello, Domenico; Morelec, Isabelle; Wagner, Tristan; Henry, Jean-François; Taïeb, David

2015-05-01

Primary hyperparathyroidism is a frequent and potentially debilitating endocrine disorder for which surgery is the only curative treatment. The modalities of parathyroid surgery have changed over the last 2 decades, as conventional bilateral neck exploration is no longer the only surgical approach. Parathyroid scintigraphy plays a major role in defining the surgical strategy, given its ability to orient a targeted (focused) parathyroidectomy and to recognize ectopic locations or multiglandular disease. This review, which represents a collaborative effort between nuclear physicians, endocrinologists, and endocrine surgeons, emphasizes the importance of performing imaging before any surgery for primary hyperparathyroidism, even in the case of conventional bilateral neck exploration. We discuss the advantages and drawbacks of targeted parathyroidectomy and the performance of various scintigraphic protocols to guide limited surgery. We also discuss the optimal strategy to localize the offending gland before reoperation for persistent or recurrent hyperparathyroidism. Finally, we describe the potential applications of novel PET tracers, with special emphasis on (18)F-fluorocholine. © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

A fast and complete GEANT4 and ROOT Object-Oriented Toolkit: GROOT

NASA Astrophysics Data System (ADS)

Lattuada, D.; Balabanski, D. L.; Chesnevskaya, S.; Costa, M.; Crucillà, V.; Guardo, G. L.; La Cognata, M.; Matei, C.; Pizzone, R. G.; Romano, S.; Spitaleri, C.; Tumino, A.; Xu, Y.

2018-01-01

Present and future gamma-beam facilities represent a great opportunity to validate and evaluate the cross-sections of many photonuclear reactions at near-threshold energies. Monte Carlo (MC) simulations are very important to evaluate the reaction rates and to maximize the detection efficiency but, unfortunately, they can be very cputime-consuming and in some cases very hard to reproduce, especially when exploring near-threshold cross-section. We developed a software that makes use of the validated tracking GEANT4 libraries and the n-body event generator of ROOT in order to provide a fast, realiable and complete MC tool to be used for nuclear physics experiments. This tool is indeed intended to be used for photonuclear reactions at γ-beam facilities with ELISSA (ELI Silicon Strip Array), a new detector array under development at the Extreme Light Infrastructure - Nuclear Physics (ELI-NP). We discuss the results of MC simulations performed to evaluate the effects of the electromagnetic induced background, of the straggling due to the target thickness and of the resolution of the silicon detectors.

Ultrastructure of the enteromonad flagellate Caviomonas mobilis.

PubMed

Brugerolle, G; Regnault, J P

2001-08-01

Caviomonas mobilis was collected from the caecum of mice harbouring a controlled fauna. Phase contrast and immunofluorescence microscopy using an anti-tubulin antibody and electron microscopy demonstrated the presence of one basal body bearing a flagellum and a second barren basal body, both inserted in the face of two cup-like depressions in the nuclear surface, as in other enteromonad/diplomonad genera. Three microtubular fibres arise close to the main basal body: the first, composed of three microtubules cross-linked with a dense structure, lies within a groove above the nuclear surface; the second is oriented antero-dorsally and corresponds to the peristyle as observed by light microscopy; and the third is situated ventrally, below the proximal part of the recurrent flagellum, and corresponds to the funis. There is no mitochondrion, no Golgi body, the endoplasmic reticulum is reduced, there is no cytostome, the cell feeds by pinocytosis and phagocytosis and the division spindle is intranuclear. The cytological characters of Caviomonas are homologous to those of genera which comprise the enteromonad/diplomonad evolutionary lineage, as previously presumed.

Protein targeting and integration signal for the chloroplastic outer envelope membrane.

PubMed Central

Li, H M; Chen, L J

1996-01-01

Most proteins in chloroplasts are encoded by the nuclear genome and synthesized in the cytosol. With the exception of most quter envelope membrane proteins, nuclear-encoded chloroplastic proteins are synthesized with N-terminal extensions that contain the chloroplast targeting information of these proteins. Most outer membrane proteins, however, are synthesized without extensions in the cytosol. Therefore, it is not clear where the chloroplastic outer membrane targeting information resides within these polypeptides. We have analyzed a chloroplastic outer membrane protein, OEP14 (outer envelope membrane protein of 14 kD, previously named OM14), and localized its outer membrane targeting and integration signal to the first 30 amino acids of the protein. This signal consists of a positively charged N-terminal portion followed by a hydrophobic core, bearing resemblance to the signal peptides of proteins targeted to the endoplasmic reticulum. However, a chimeric protein containing this signal fused to a passenger protein did not integrate into the endoplasmic reticulum membrane. Furthermore, membrane topology analysis indicated that the signal inserts into the chloroplastic outer membrane in an orientation opposite to that predicted by the "positive inside" rule. PMID:8953775

Micropatterned Azopolymer Surfaces Modulate Cell Mechanics and Cytoskeleton Structure.

PubMed

Rianna, Carmela; Ventre, Maurizio; Cavalli, Silvia; Radmacher, Manfred; Netti, Paolo A

2015-09-30

Physical and chemical characteristics of materials are important regulators of cell behavior. In particular, cell elasticity is a fundamental parameter that reflects the state of a cell. Surface topography finely modulates cell fate and function via adhesion mediated signaling and cytoskeleton generated forces. However, how topographies alter cell mechanics is still unclear. In this work we have analyzed the mechanical properties of peripheral and nuclear regions of NIH-3T3 cells on azopolymer substrates with different topographic patterns. Micrometer scale patterns in the form of parallel ridges or square lattices of surface elevations were encoded on light responsive azopolymer films by means of contactless optical methods. Cell mechanics was investigated by atomic force microscopy (AFM). Cells and consequently the cell cytoskeleton were oriented along the linear patterns affecting cytoskeletal structures, e.g., formation of actin stress fibers. Our data demonstrate that topographic substrate patterns are recognized by cells and mechanical information is transferred by the cytoskeleton. Furthermore, cytoskeleton generated forces deform the nucleus, changing its morphology that appears to be related to different mechanical properties in the nuclear region.

Quantum-Critical Dynamics of the Skyrmion Lattice.

NASA Astrophysics Data System (ADS)

Green, Andrew G.

2002-03-01

Slightly away from exact filling of the lowest Landau level, the quantum Hall ferromagnet contains a finite density of magnetic vortices or Skyrmions[1,2]. These Skyrmions are expected to form a square lattice[3], the low energy excitations of which (translation/phonon modes and rotation/breathing modes) lead to dramatically enhanced nuclear relaxation[4,5]. Upon changing the filling fraction, the rotational modes undergo a quantum phase transition where zero-point fluctuations destroy the orientational order of the Skyrmions[4,6]. I will discuss the effect of this quantum critical point upon nuclear spin relaxation[7]. [1]S. L. Sondhi et al., Phys. Rev. B47, 16419 (1993). [2]S. E. Barrett et al., Phys. Rev. Lett. 74, 5112 (1995), A. Schmeller et al., Phys. Rev. Lett. 75, 4290 (1995). [3]L. Brey et al, Phys. Rev. Lett. 75, 2562 (1995). [4]R. Côté et al., Phys. Rev. Lett. 78, 4825 (1997). [5]R. Tycko et al., Science 268, 1460 (1995). [6]Yu V. Nazarov and A. V. Khaetskii, Phys. Rev. Lett. 80, 576 (1998). [7]A. G. Green, Phys. Rev. B61, R16 299 (2000).

Theoretical comparison and experimental test of the secular and nonperturbative approaches on the ESR lineshapes of randomly oriented, anisotropic systems undergoing internal motion

NASA Astrophysics Data System (ADS)

Benetis, N. P.; Sjöqvist, L.; Lund, A.; Maruani, J.

The nuclear Zeeman and the electronic nonsecular parts of the spin Hamiltonian complicate the ESR lineshape of exchanging anisotropic spin systems by introducing, at high field, "forbidden" transitions and, at low field, additional shift and splitting. We compare the nonperturbative with the secular approach for such systems. The exchange is treated within the Kaplan-Alexander limit and both A and g tensors are included, resulting in spectrum asymmetry, in contrast to previous separate treatments. The two approaches are then used to simulate the powder spectrum of OCH 2COO - and compare the results to experimental spectra of an irradiated powder of ZnAc. The powder X-band spectra simulations using the secular approach appear to be accurate. For both the low-field (20 to 200 G) and the high-field (Q-band) regions, however, the nonsecular part of the electronic term and the nuclear Zeeman term, respectively, cannot be neglected. On the other hand, the approximate approach is much faster and consequently more appropriate for treating large, multisite exchanging systems.

A baculovirus dual expression vector derived from the Autographa californica nuclear polyhedrosis virus polyhedrin and p10 promoters: co-expression of two influenza virus genes in insect cells.

PubMed

Weyer, U; Possee, R D

1991-12-01

A baculovirus transfer vector, pAcUW3, was developed to facilitate the insertion of two influenza virus genes, those encoding the haemagglutinin (HA) and neuraminidase (NA) membrane glycoproteins, into the Autographa californica nuclear polyhedrosis virus genome in a single cotransfection experiment. The NA gene was inserted in place of the polyhedrin coding sequences under the control of the polyhedrin promoter, whereas the HA gene was placed under the control of a copy of the p10 promoter at a site upstream of and in opposite orientation to the polyhedrin promoter. After infection of Spodoptera frugiperda cells with the recombinant virus, AcUW3HANA, both HA and NA were expressed in the very late phase of infection and were shown to be functional in appropriate assays. Immunofluorescence assays demonstrated their localization at the surface of infected insect cells. The expression of both foreign genes in the recombinant virus was found to be stable for at least 12 passages in cell culture.