Sample records for nuclear structure summary

  1. Co-ordination of the International Network of Nuclear Structure and Decay Data Evaluators; Summary Report of an IAEA Technical Meeting

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abriola, D.; Tuli, J.

    The IAEA Nuclear Data Section convened the 18th meeting of the International Network of Nuclear Structure and Decay Data Evaluators at the IAEA Headquarters, Vienna, 23 to 27 March 2009. This meeting was attended by 22 scientists from 14 Member States, plus IAEA staff, concerned with the compilation, evaluation and dissemination of nuclear structure and decay data. A summary of the meeting, recommendations/conclusions, data centre reports, and various proposals considered, modified and agreed by the participants are contained within this document. The International Network of Nuclear Structure and Decay Data (NSDD) Evaluators holds biennial meetings under the auspices of themore » IAEA, and consists of evaluation groups and data service centres in several countries. This network has the objective of providing up-to-date nuclear structure and decay data for all known nuclides by evaluating all existing experimental data. Data resulting from this international evaluation collaboration is included in the Evaluated Nuclear Structure Data File (ENSDF) and published in the journals Nuclear Physics A and Nuclear Data Sheets (NDS).« less

  2. Nuclear Data Sheets for A = 148

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nica, N.

    2014-04-02

    The experimental nuclear structure data available through October 2013 have been reviewed. A summary of information obtained in various reaction and decay experiments is presented, together with adopted level schemes.

  3. Comparative analysis of structural concrete Quality Assurance practices on nine nuclear and three fossil fuel power plant construction projects. Final summary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Willenbrock, J.H.; Thomas, H.R. Jr.; Burati, J.J. Jr.

    1978-12-01

    A summary of two reports, COO/4120-1 and COO/4120-2, is given. A comparative analysis was made of the Quality Assurance practices related to the structural concrete phase on nine nuclear and three fossil fuel power plant projects which are (or have been) under construction in the United States in the past ten years. For the nuclear projects the analysis identified the response of each Quality Assurance program to the applicable criteria of 10 CFR Part 50, Appendix B as well as to the pertinent regulatory requirements and industry standards. For the fossil projects the analysis identified the response of each Qualitymore » Assurance program to criteria similar to those which were applicable in the nuclear situation. The major emphasis was placed on the construction aspects of the structural concrete phase of each project. The engineering and design aspects were examined whenever they interfaced with the construction aspects.« less

  4. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ricard-McCutchan, E.; Dimitriou, P.; Nichols, A. L.

    The 21st meeting of the International Network of Nuclear Structure and Decay Data Evaluators was convened at the IAEA Headquarters, Vienna, from 20 to 24 April 2015 under the auspices of the IAEA Nuclear Data Section. This meeting was attended by 36 scientists from 15 Member States, plus IAEA staff, concerned with the compilation, evaluation and dissemination of nuclear structure and decay data. A summary of the meeting, data centre reports, various proposals considered, and actions agreed by the participants, as well as recommendations/conclusions are presented within this document.

  5. INDC International Nuclear Data Committee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nichols, A.; McCutchan, E.; Dimitriou, P.

    The 22nd meeting of the International Network of Nuclear Structure and Decay Data Evaluators was convened at the Lawrence Berkeley National Laboratory, Berkeley, USA, from 22 to 26 May 2017 under the auspices of the IAEA Nuclear Data Section. This meeting was attended by 38 scientists from 12 Member States and the IAEA, all of whom are concerned primarily with the measurement, evaluation and dissemination of nuclear structure and decay data. A summary of the meeting, data centre reports, various proposals considered, technical discussions, actions agreed by the participants, and the resulting recommendations/conclusions are presented within this document.

  6. 10 CFR 74.17 - Special nuclear material physical inventory summary report.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Special nuclear material physical inventory summary report. 74.17 Section 74.17 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL General Reporting and Recordkeeping Requirements § 74.17 Special nuclear...

  7. 10 CFR 74.17 - Special nuclear material physical inventory summary report.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Special nuclear material physical inventory summary report. 74.17 Section 74.17 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL General Reporting and Recordkeeping Requirements § 74.17 Special nuclear...

  8. 10 CFR 74.17 - Special nuclear material physical inventory summary report.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Special nuclear material physical inventory summary report. 74.17 Section 74.17 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL General Reporting and Recordkeeping Requirements § 74.17 Special nuclear...

  9. 10 CFR 74.17 - Special nuclear material physical inventory summary report.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Special nuclear material physical inventory summary report. 74.17 Section 74.17 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL General Reporting and Recordkeeping Requirements § 74.17 Special nuclear...

  10. 10 CFR 74.17 - Special nuclear material physical inventory summary report.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Special nuclear material physical inventory summary report. 74.17 Section 74.17 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL General Reporting and Recordkeeping Requirements § 74.17 Special nuclear...

  11. Operation REDWING. Technical Summary of Military Effects. Programs 1-9

    DTIC Science & Technology

    1981-05-15

    study chorioretinal burns. The primary objective of the program on effects on aircraft structures was to ascer- tain the reliability of current weapons...other aircraft. In the program of tests on service equipment and studies of electromagnetic effects,I 4k. the emphasis was placed on studying long...range detection of nuclear explosions. An additional objective was the study of the effects of nuclear detonations on the ionosphere and microwave

  12. Summary Report of a Specialized Workshop on Nuclear Structure and Decay Data (NSDD) Evaluations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nichols, Alan L.; Dimitrious, P.; Kondev, F. G.

    2015-04-27

    A three-day specialised workshop on Nuclear Structure and Decay Data Evaluations was organised and held at the headquarters of the International Atomic Energy Agency in Vienna, Austria, from 27 to 29 April 2015. This workshop covered a wide range of important topics and issues addressed when evaluating and maintaining the Evaluated Nuclear Structure Data File (ENSDF). The primary aim was to improve evaluators’ abilities to identify and understand the most appropriate evaluation processes to adopt in the formulation of individual ENSDF data sets. Participants assessed and reviewed existing policies, procedures and codes, and round-table discussions included the debate and resolutionmore » of specific difficulties experienced by ENSDF evaluators (i.e., all workshop participants). The contents of this report constitute a record of this workshop, based on the presentations and subsequent discussions.« less

  13. FAMILY STRUCTURE, DYNAMICS AND PSYCHIATRIC DISORDER IN INDIA1

    PubMed Central

    Chopra, H.D.

    1984-01-01

    SUMMARY This paper briefly reviews the literature on family structure, dynamics and relationships between family-jointness and different psychiatric disorders in India. Many recent studies indicate that the nuclear families are more vulnerable and plea is made for maintaining the traditional joint family system, even in some modified forms, because of its “built-in-immunity” and supportive networks. PMID:21966010

  14. Summary of Prometheus Radiation Shielding Nuclear Design Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J. Stephens

    2006-01-13

    This report transmits a summary of radiation shielding nuclear design studies performed to support the Prometheus project. Together, the enclosures and references associated with this document describe NRPCT (KAPL & Bettis) shielding nuclear design analyses done for the project.

  15. NASA/DOE/DOD nuclear propulsion technology planning: Summary of FY 1991 interagency panel results

    NASA Technical Reports Server (NTRS)

    Clark, John S.; Wickenheiser, Timothy J.; Doherty, Michael P.; Marshall, Albert; Bhattacharryya, Samit K.; Warren, John

    1992-01-01

    Interagency (NASA/DOE/DOD) technical panels worked in 1991 to evaluate critical nuclear propulsion issues, compare nuclear propulsion concepts for a manned Mars mission on a consistent basis, and to continue planning a technology development project for the Space Exploration Initiative (SEI). Panels were formed to address mission analysis, nuclear facilities, safety policy, nuclear fuels and materials, nuclear electric propulsion technology, and nuclear thermal propulsion technology. A summary of the results and recommendations of the panels is presented.

  16. OAST Space Theme Workshop. Volume 2: Theme summary. 2: Space industrialization (no. 8). A. Theme statement. B. 26 April 1976 presentation. C. Summary statement. D. Initiative action (form 5)

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Enabling technology needs and other requirements to support space industrialization include: large space structures; fabrication and joining processes; single stage to orbit and heavy lift launch vehicles; nuclear and solar space power systems; robotics, manipulators, and teleoperators; biotechnology in space; artificial gravity; the utilization of lunar materials for construction; and the extraction of oxygen and metals from lunar resources. New initiatives (FY 1978) directly supportive or partly related to space industrialization are listed.

  17. Nuclear Data Sheets for A=243

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nesaraja, Caroline D; McCutchan, Elizabeth A.

    2014-09-30

    We present available information pertaining to the nuclear structure of all nuclei with mass numbers A=243. Various decay and reaction data are evaluated and compared. Adopted data, levels, spin, parity and configuration assignments are given. When there are insufficient data, expected values from systematics of nuclear properties or/and theoretical calculations are quoted. Unexpected or discrepant experimental results are also noted. A summary and compilation of the discovery of various isotopes in this mass region is given in 2013Fr02 ( 243Np, 243Pu, 243Am, 243Cm, 243Bk, and 243Cf), 2011Me01 ( 243Es), and 2013Th02 ( 243Fm).

  18. Transactions of the Twenty-First Water Reactor Safety Information Meeting

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Monteleone, S.

    1993-10-01

    This report contains summaries of papers on reactor safety research to be presented at the 21st Water Reactor Safety Information Meeting at the Bethesda Marriott Hotel, Bethesda, Maryland, October 25--27, 1993. The summaries briefly describe the programs and results of nuclear safety research sponsored by the Office of Nuclear Regulatory Research, US NRC. Summaries of invited papers concerning nuclear safety issues from US government laboratories, the electric utilities, the Electric Power Research Institute (EPRI), the nuclear industry, and from foreign governments and industry are also included. The summaries have been compiled in one report to provide a basis for meaningfulmore » discussion and information exchange during the course of the meeting and are given in the order of their presentation in each session.« less

  19. High elongation elastomers

    NASA Technical Reports Server (NTRS)

    Brady, V. L.; Reed, R.; Merwin, L.; Nissan, R.

    1994-01-01

    A new class of liquid curable elastomers with unusual strength and elasticity has been developed at the Naval Air Warfare Center Weapons Division, China Lake. Over the years, studies have been conducted on polymer structure and its influence on the mechanical properties of the ensuing composites. Different tools, including nuclear magnetic resonance, have been used. This paper presents a summary of the factors controlling the mechanical behavior of composites produced with the new liquid curable elastomers, including the effects of plasticizers. It also provides an overview of the nuclear magnetic resonance study on polymer structure, the composition and properties of some live and inert formulations produced at China Lake, and some possible peace-time applications for these new elastomeric materials.

  20. Maintenance of a functional higher order chromatin structure: The role of the nuclear matrix in normal and disease states

    PubMed Central

    Linnemann, Amelia K.; Krawetz, Stephen A.

    2010-01-01

    Summary The ordered packaging of DNA within the nucleus of somatic cells reflects a dynamic supportive structure that facilitates stable transcription interrupted by intermittent cycles of extreme condensation. This dynamic mode of packing and unpacking chromatin is intimately linked to the ability of the genome to specifically complex with both histones and non-histone proteins. Understanding the underlying mechanism that governs the formation of higher order chromatin structures is a key to understanding how local architecture modulates transcription. In part, the formation of these structures appears to be regulated through genomic looping that is dynamically mediated by attachment to the nuclear scaffold/matrix at S/MARs, i.e., Scaffold/Matrix Attachment Regions. Although the mechanism guiding the formation and use of these higher-ordered structures remains unknown, S/MARs continue to reveal a multitude of roles in development and the pathogenesis of disease. PMID:20948980

  1. Summary Proceedings of the Congress of International Physicians for the Prevention of Nuclear War (2nd, Cambridge, England, April, 1982).

    ERIC Educational Resources Information Center

    International Physicians for the Prevention of Nuclear War, Inc., Boston, MA.

    This conference was held to alert physicians worldwide of the mortal peril of nuclear war to public health, with the hope that they will help educate their communities about the effects of nuclear war. Summary papers prepared during the conference include: medical consequences of nuclear war with special reference to Europe--immediate problems for…

  2. International nuclear fuel cycle fact book. Revision 4

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harmon, K.M.; Lakey, L.T.; Leigh, I.W.

    This Fact Book has been compiled in an effort to provide (1) an overview of worldwide nuclear power and fuel cycle programs and (2) current data concerning fuel cycle and waste management facilities, R and D programs, and key personnel in countries other than the United States. Additional information on each country's program is available in the International Source Book: Nuclear Fuel Cycle Research and Development, PNL-2478, Rev. 2. The Fact Book is organized as follows: (1) Overview section - summary tables which indicate national involvement in nuclear reactor, fuel cycle, and waste management development activities; (2) national summaries -more » a section for each country which summarizes nuclear policy, describes organizational relationships and provides addresses, names of key personnel, and facilities information; (3) international agencies - a section for each of the international agencies which has significant fuel cycle involvement; (4) energy supply and demand - summary tables, including nuclear power projections; (5) fuel cycle - summary tables; and (6) travel aids - international dialing instructions, international standard time chart, passport and visa requirements, and currency exchange rate.« less

  3. International Nuclear Fuel Cycle Fact Book. Revision 5

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harmon, K.M.; Lakey, L.T.; Leigh, I.W.

    This Fact Book has been compiled in an effort to provide: (1) an overview of worldwide nuclear power and fuel cycle programs; and (2) current data concerning fuel cycle and waste management facilities, R and D programs, and key personnel in countries other than the United States. Additional information on each country's program is available in the International Source Book: Nuclear Fuel Cycle Research and Development, PNL-2478, Rev. 2. The Fact Book is organized as follows: (1) Overview section - summary tables which indicate national involvement in nuclear reactor, fuel cycle, and waste management development activities; (2) national summaries -more » a section for each country which summarizes nuclear policy, describes organizational relationships and provides addresses, names of key personnel, and facilities information; (3) international agencies - a section for each of the international agencies which has significant fuel cycle involvement; (4) energy supply and demand - summary tables, including nuclear power projections; (5) fuel cycle - summary tables; and (6) travel aids international dialing instructions, international standard time chart, passport and visa requirements, and currency exchange rate.« less

  4. Justification and Persuasion about Cloning: Arguments in Hwang's Paper and Journalistic Reported Versions

    ERIC Educational Resources Information Center

    Jimenez-Aleixandre, Maria Pilar; Federico-Agraso, Marta

    2009-01-01

    We examine the argumentative structure of Hwang et al.'s (2004) paper about human somatic cell nuclear transfer (SCNT, or "therapeutic cloning"), contrasted with four Journalistic Reported Versions (JRV) of it, and with students' summaries of one JRV. As the evaluation of evidence is one of the critical features of argumentation…

  5. Bonner Prize Address: Measurements of the electromagnetic properties of nucleons and nuclei at short distance scales

    NASA Astrophysics Data System (ADS)

    Raymond, Arnold

    2000-04-01

    The talk will present the story of a series of experiments, beginning in 1973 and continuing today, that have measured the internal structure of nuclei and the nucleons using high energy beams of electrons and photons at the Stanford Linear Accelerator Center. These experiments have probed nuclear and nucleon structure in the energy and momentum transfer region where the meson-nucleon description merges with the quark-gluon picture. The experiments have worked at the border between nuclear and particle physics, and were conducted by large collaborative teams. Some were carried out in the context of a special program, called NPAS (Nuclear Physics at SLAC). The early results from these measurements helped stimulate the ideas and helped train and motivate the physicists who went on to build the Jefferson Laboratory. A brief summary of some highlights from the early measurements and updates on recent results will be given.

  6. Living near nuclear power plants and thyroid cancer risk: A systematic review and meta-analysis.

    PubMed

    Kim, Jaeyoung; Bang, Yejin; Lee, Won Jin

    2016-02-01

    There has been public concern regarding the safety of residing near nuclear power plants, and the extent of risk for thyroid cancer among adults living near nuclear power plants has not been fully explored. In the present study, a systematic review and meta-analysis of epidemiologic studies was conducted to investigate the association between living near nuclear power plants and the risk of thyroid cancer. A comprehensive literature search was performed on studies published up to March 2015 on the association between nuclear power plants and thyroid cancer risk. The summary standardized incidence ratio (SIR), standardized mortality ratio (SMR), and 95% confidence intervals (CIs) were calculated using a random-effect model of meta-analysis. Sensitivity analyses were performed by study quality. Thirteen studies were included in the meta-analysis, covering 36 nuclear power stations in 10 countries. Overall, summary estimates showed no significant increased thyroid cancer incidence or mortality among residents living near nuclear power plants (summary SIR=0.98; 95% CI 0.87-1.11, summary SMR=0.80; 95% CI 0.62-1.04). The pooled estimates did not reveal different patterns of risk by gender, exposure definition, or reference population. However, sensitivity analysis by exposure definition showed that living less than 20 km from nuclear power plants was associated with a significant increase in the risk of thyroid cancer in well-designed studies (summary OR=1.75; 95% CI 1.17-2.64). Our study does not support an association between living near nuclear power plants and risk of thyroid cancer but does support a need for well-designed future studies. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Summary documentation of LASL nuclear data evaluations for ENDF/B-V

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Young, P.G.

    1979-01-01

    Summaries are presented of nuclear data evaluations performed at Los Alamos Scientific Laboratory (LASL) that will comprise part of Version V of the Evaluated Nuclear Data File, ENDF/B. A total of 18 general purpose evaluations of neutron-induced data are summarized, together with 6 summaries directed specifically at covariance data evaluations. The general purpose evaluation summaries cover the following isotopes: /sup 1 -3/H, /sup 3/ /sup 4/He, /sup 6/ /sup 7/Li, /sup 10/B, /sup 14/ /sup 15/N, /sup 16/O, /sup 27/Al, /sup 182/ /sup 183/ /sup 184/ /sup 186/W, /sup 233/U, and /sup 242/Pu. The covariance data summaries are given formore » /sup 1/H, /sup 6/Li, /sup 10/B, /sup 14/N, /sup 16/O, and /sup 27/Al. 28 figures.« less

  8. Nuclear Data Sheets for A=241

    DOE PAGES

    Nesaraja, Caroline D.

    2015-11-27

    This paper presents available information pertaining to the nuclear structure of ground and excited states for all known nuclei with mass numbers A=24, which have been compiled and evaluated. The adopted level and decay schemes, as well as the detailed nuclear properties and configuration assignments based on experimental data are presented for these nuclides. When there are insufficient data, expected values from systematics of nuclear properties or/and theoretical calculations are quoted. Unexpected or discrepant experimental results are also noted. A summary and compilation of the discovery of various isotopes in this mass region is given in 2013Fr02 ( 241Np, 241Pu,more » 241Am, 241Cm, 241Bk, and 241Cf), 2011Me01 (241Es), and 2013Th02 ( 241Fm).« less

  9. Instituting Nuclear Age Education: Towards a Cooperative Future. Proceedings of the International Student Pugwash Symposium (Atlanta, Georgia, January 20-23, 1983). [Summary].

    ERIC Educational Resources Information Center

    International Student Pugwash, Washington, DC.

    Proceedings of a symposium which focused on issues related to nuclear weapons and arms control are presented. In addition to a list of participants (including both high school and college educators) and symposium schedule, summaries/highlights of symposium sessions are provided. These include summaries of three working groups which discussed…

  10. Neuronal differentiation modulates the dystrophin Dp71d binding to the nuclear matrix

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rodriguez-Munoz, Rafael; Villarreal-Silva, Marcela; Gonzalez-Ramirez, Ricardo

    The function of dystrophin Dp71 in neuronal cells remains unknown. To approach this issue, we have selected the PC12 neuronal cell line. These cells express both a Dp71f cytoplasmic variant and a Dp71d nuclear isoform. In this study, we demonstrated by electron and confocal microscopy analyses of in situ nuclear matrices and Western blotting evaluation of cell extracts that Dp71d associates with the nuclear matrix. Interestingly, this binding is modulated during NGF-induced neuronal differentiation of PC12 cells with a twofold increment in the differentiated cells, compared to control cells. Also, distribution of Dp71d along the periphery of the nuclear matrixmore » observed in the undifferentiated cells is replaced by intense fluorescent foci localized in Center of the nucleoskeletal structure. In summary, we revealed that Dp71d is a dynamic component of nuclear matrix that might participate in the nuclear modeling occurring during neuronal differentiation.« less

  11. Transmutation of Radioactive Nuclear Waste — Present Status and Requirement for the Problem-Oriented Nuclear Database: Approach to Scheduling the Experiments (Reactor, Target, Blanket)

    NASA Astrophysics Data System (ADS)

    Artisyuk, V.; Ignatyuk, A.; Korovin, Yu.; Lopatkin, A.; Matveenko, I.; Stankovskiy, A.; Titarenko, Yu.

    2005-05-01

    Transmutation of nuclear wastes (Minor Actinides and Long-Lived Fission Products) remains an important option to reduce the burden of high-level waste on final waste disposal in deep geological structures. Accelerator-Driven Systems (ADS) are considered as possible candidates to perform transmutation due to their subcritical operation mode that eliminates some of the serious safety penalties unavoidable in critical reactors. Specific requirements to nuclear data necessary for ADS transmutation analysis is the main subject of the ISTC Project ♯2578 which started in 2004 to identify the areas of research priorities in the future. The present paper gives a summary of ongoing project stressing the importance of nuclear data for blanket performance (reactivity behavior with associated safety characteristics) and uncertainties that affect characteristics of neutron producing target.

  12. Nuclear Data Sheets for A = 196

    NASA Astrophysics Data System (ADS)

    Xiaolong, Huang

    2007-06-01

    The 1998 version of nuclear data sheets for A = 196 has been revised and updated on the basis of the experimental results from various decay and reaction studies before January 2006. The experimental data for all known nuclei of A = 196 (Os,Ir,Pt,Au,Hg, Tl,Pb,Bi,Po,At,Rn) have been reevaluated. The experimental methods, references,Jπ arguments,and necessary comments are given in the text. Summary band structure drawings and level schemes from both radioactive decay and reaction studies are presented. Also of special interest are the new identification of superdeformed bands in 196Pb and 196Bi.

  13. 1L Mark-IV Target Design Review

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Koehler, Paul E.

    This presentation includes General Design Considerations; Current (Mark-III) Lower Tier; Mark-III Upper Tier; Performance Metrics; General Improvements for Material Science; General Improvements for Nuclear Science; Improving FOM for Nuclear Science; General Design Considerations Summary; Design Optimization Studies; Expected Mark-IV Performance: Material Science; Expected Mark-IV Performance: Nuclear Science (Disk); Mark IV Enables Much Wider Range of Nuclear-Science FOM Gains than Mark III; Mark-IV Performance Summary; Rod or Disk? Center or Real FOV?; and Project Cost and Schedule.

  14. Standardization and economics of nuclear spacecraft: Executive summary

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Feasibility and cost benefits of nuclear-powered standardized spacecraft were investigated. The study indicates that two shuttle-launched nuclear-powered spacecraft should be able to serve the majority of unmanned NASA missions anticipated for the 1980's. The standard spacecraft include structure, thermal control, power, attitude control, some propulsion capability and tracking, telemetry, and command subsystems. One spacecraft design, powered by the radioisotope thermoelectric generator, can serve missions requiring up to 450 watts. The other spacecraft design, powered by similar nuclear heat sources in a Brayton-cycle generator, can serve missions requiring up to 2200 watts. Design concepts and trade-offs are discussed. The conceptual designs selected are presented and successfully tested against a variety of missions. The thermal design is such that both spacecraft are capable of operating in any earth orbit and any orientation without modification.

  15. Summary Report of the Workshop on The Experimental Nuclear Reaction Data Database

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Semkova, V.; Pritychenko, B.

    2014-12-01

    The Workshop on the Experimental Nuclear Reaction Data Database (EXFOR) was held at IAEA Headquarters in Vienna from 6 to 10 October 2014. The workshop was organized to discuss various aspects of the EXFOR compilation process including compilation rules, different techniques for nuclear reaction data measurements, software developments, etc. A summary of the presentations and discussions that took place during the workshop is reported here.

  16. Nuclear power plant Generic Aging Lessons Learned (GALL). Main report and appendix A

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kaza, K.E.; Diercks, D.R.; Holland, J.W.

    The purpose of this generic aging lessons learned (GALL) review is to provide a systematic review of plant aging information in order to assess materials and component aging issues related to continued operation and license renewal of operating reactors. Literature on mechanical, structural, and thermal-hydraulic components and systems reviewed consisted of 97 Nuclear Plant Aging Research (NPAR) reports, 23 NRC Generic Letters, 154 Information Notices, 29 Licensee Event Reports (LERs), 4 Bulletins, and 9 Nuclear Management and Resources Council Industry Reports (NUMARC IRs) and literature on electrical components and systems reviewed consisted of 66 NPAR reports, 8 NRC Generic Letters,more » 111 Information Notices, 53 LERs, 1 Bulletin, and 1 NUMARC IR. More than 550 documents were reviewed. The results of these reviews were systematized using a standardized GALL tabular format and standardized definitions of aging-related degradation mechanisms and effects. The tables are included in volume s 1 and 2 of this report. A computerized data base has also been developed for all review tables and can be used to expedite the search for desired information on structures, components, and relevant aging effects. A survey of the GALL tables reveals that all ongoing significant component aging issues are currently being addressed by the regulatory process. However, the aging of what are termed passive components has been highlighted for continued scrutiny. This document is Volume 1, consisting of the executive summary, summary and observations, and an appendix listing the GALL literature review tables.« less

  17. 77 FR 40091 - Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating, Units 2 and 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-247 and 50-286; NRC-2008-0672] Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating, Units 2 and 3 AGENCY: Nuclear Regulatory Commission... renewal of nuclear plants; availability. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the...

  18. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nesaraja, C.D.

    Available information pertaining to the nuclear structure of all nuclei with mass numbers A=247 is presented. Various decay and reaction data are evaluated and compared. Adopted data, levels, spin, parity and configuration assignments are given. When there are insufficient data, expected values from systematics of nuclear properties or/and theoretical calculations are quoted. Unexpected or discrepant experimental results are also noted. A summary and compilation of the discovery of various isotopes in this mass region is given in 2013Fr02 ({sup 247}Pu, {sup 247}Am, {sup 247}Cm, {sup 243}Bk, {sup 247}Cf), 2011Me01 ({sup 247}Es), and 2013Th02 ({sup 247}Fm, {sup 247}Md)

  19. Materials technology for an advanced space power nuclear reactor concept: Program summary

    NASA Technical Reports Server (NTRS)

    Gluyas, R. E.; Watson, G. K.

    1975-01-01

    The results of a materials technology program for a long-life (50,000 hr), high-temperature (950 C coolant outlet), lithium-cooled, nuclear space power reactor concept are reviewed and discussed. Fabrication methods and compatibility and property data were developed for candidate materials for fuel pins and, to a lesser extent, for potential control systems, reflectors, reactor vessel and piping, and other reactor structural materials. The effects of selected materials variables on fuel pin irradiation performance were determined. The most promising materials for fuel pins were found to be 85 percent dense uranium mononitride (UN) fuel clad with tungsten-lined T-111 (Ta-8W-2Hf).

  20. 76 FR 23798 - Nuclear Energy Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee; Meeting AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear... [email protected]nuclear.energy.gov . SUPPLEMENTARY INFORMATION: Background: The Nuclear Energy Advisory...

  1. 78 FR 52987 - Entergy Nuclear Operations, Inc., Indian Point Nuclear Generating Unit 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 50-286; NRC-2013-0063] Entergy Nuclear Operations, Inc., Indian Point Nuclear Generating Unit 3 AGENCY: Nuclear Regulatory Commission. ACTION: Environmental assessment and finding of no significant impact; issuance. SUMMARY: The U.S. Nuclear Regulatory Commission...

  2. 77 FR 70847 - Entergy Nuclear Indian Point 2, LLC; Entergy Nuclear Operations, Inc., Indian Point Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 50-247; NRC-2012-0284] Entergy Nuclear Indian Point 2, LLC; Entergy Nuclear Operations, Inc., Indian Point Nuclear Generating Unit No. 2, Request for Action AGENCY: Nuclear Regulatory Commission. ACTION: Request for Action; receipt. SUMMARY: The U.S. Nuclear...

  3. World Energy Data System (WENDS). Volume XI. Nuclear fission program summaries

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1979-06-01

    Brief management and technical summaries of nuclear fission power programs are presented for nineteen countries. The programs include the following: fuel supply, resource recovery, enrichment, fuel fabrication, light water reactors, heavy water reactors, gas cooled reactors, breeder reactors, research and test reactors, spent fuel processing, waste management, and safety and environment. (JWR)

  4. Secondary Fire Analysis.

    DTIC Science & Technology

    1981-09-01

    of wood frame and brick veneer, slab on grade construction), killed 33, injured more than 1,000, derailed a train, destroyed 4,000 cars, uprooted most... of a nuclear detonation) in or near structures, with emphasis on critical facil- ities and industries. Assessment of the potential for secondary fires...and/or 517 East Dayshore, Redwood City, CA 94063 DistI pial (DETACHABLE SUMMARY) SECONDARY FIRE ANALYSIS This report presents the results of a

  5. Florida state information handbook: formerly utilized sites remedial action program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the federal and state levels, the pertinent programs they administer, each affected state legislature, and current federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Florida. It contains a description ofmore » the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.« less

  6. 78 FR 39018 - Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating Unit Nos. 2 and 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-247 and 50-286; NRC-2008-0672] Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating Unit Nos. 2 and 3 AGENCY: Nuclear Regulatory Commission... Renewal of Nuclear Plants; issuance. SUMMARY: Notice is hereby given that the U.S. Nuclear Regulatory...

  7. 78 FR 26795 - Announcement of Requirements and Registration for the National Radiological and Nuclear Detection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-08

    ... Radiological and Nuclear Detection Challenge AGENCY: Domestic Nuclear Detection Office, DHS. ACTION: Notice. SUMMARY: DNDO announces the National Radiological and Nuclear Detection (Rad/Nuc) Challenge, a...), Domestic Nuclear Detection Office (DNDO), announces the National Radiological and Nuclear Detection (Rad...

  8. 10 CFR 2.1205 - Summary disposition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Summary disposition. 2.1205 Section 2.1205 Energy NUCLEAR... Hearing Procedures for NRC Adjudications § 2.1205 Summary disposition. (a) Unless the presiding officer or the Commission directs otherwise, motions for summary disposition may be submitted to the presiding...

  9. 76 FR 65541 - Assuring the Availability of Funds for Decommissioning Nuclear Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... NUCLEAR REGULATORY COMMISSION [NRC-2009-0263] Assuring the Availability of Funds for Decommissioning Nuclear Reactors AGENCY: Nuclear Regulatory Commission. ACTION: Regulatory guide; issuance. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or Commission) is issuing a revision to Regulatory...

  10. Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells

    PubMed Central

    Costello, M. Joseph; Brennan, Lisa A.; Gilliland, Kurt O.; Johnsen, Sönke; Kantorow, Marc

    2016-01-01

    An unresolved issue in structural biology is how the encapsulated lens removes membranous organelles to carry out its role as a transparent optical element. In this ultrastructural study, we establish a mechanism for nuclear elimination in the developing chick lens during the formation of the organelle-free zone. Day 12–15 chick embryo lenses were examined by high-resolution confocal light microscopy and thin section transmission electron microscopy (TEM) following fixation in 10% formalin and 4% paraformaldehyde, and then processing for confocal or TEM as described previously. Examination of developing fiber cells revealed normal nuclei with dispersed chromatin and clear nucleoli typical of cells in active ribosome production to support protein synthesis. Early signs of nuclear degradation were observed about 300 μm from the lens capsule in Day 15 lenses where the nuclei display irregular nuclear stain and prominent indentations that sometimes contained a previously undescribed macromolecular aggregate attached to the nuclear envelope. We have termed this novel structure the nuclear excisosome. This complex by confocal is closely adherent to the nuclear envelope and by TEM appears to degrade the outer leaflet of the nuclear envelope, then the inner leaflet up to 500 μm depth. The images suggest that the nuclear excisosome separates nuclear membrane proteins from lipids, which then form multilamellar assemblies that stain intensely in confocal and in TEM have 5 nm spacing consistent with pure lipid bilayers. The denuded nucleoplasm then degrades by condensation and loss of structure in the range 600 to 700 μm depth producing pyknotic nuclear remnants. None of these stages display any classic autophagic vesicles or lysosomes associated with nuclei. Uniquely, the origin of the nuclear excisosome is from filopodial-like projections of adjacent lens fiber cells that initially contact, and then appear to fuse with the outer nuclear membrane. These filopodial-like projections appear to be initiated with a clathrin-like coat and driven by an internal actin network. In summary, a specialized cellular organelle, the nuclear excisosome, generated in part by adjacent fiber cells degrades nuclei during fiber cell differentiation and maturation. PMID:27536868

  11. Evaluation of Nuclear Facility Decommissioning Projects program: a reference research reactor. Project summary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baumann, B.L.; Miller, R.L.

    1983-10-01

    This document presents, in summary form, generic conceptual information relevant to the decommissioning of a reference research reactor (RRR). All of the data presented were extracted from NUREG/CR-1756 and arranged in a form that will provide a basis for future comparison studies for the Evaluation of Nuclear Facility Decommissioning Projects (ENFDP) program.

  12. 78 FR 59982 - Revisions to Radiation Protection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0268] Revisions to Radiation Protection AGENCY: Nuclear Regulatory Commission. ACTION: Standard review plan section; issuance. SUMMARY: The U.S. Nuclear Regulatory... for the Review of Safety Analysis Reports for Nuclear Power Plants: LWR Edition'': Section 12.1...

  13. 78 FR 66785 - Korea Hydro and Nuclear Power Co., Ltd., and Korea Electric Power Corporation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... NUCLEAR REGULATORY COMMISSION [Project No. 0782; NRC-2013-0244] Korea Hydro and Nuclear Power Co., Ltd., and Korea Electric Power Corporation AGENCY: Nuclear Regulatory Commission. ACTION: Notice of receipt; availability. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) staff acknowledges receipt of...

  14. 76 FR 31379 - Notice of Issuance of Bulletin 2011-01, Mitigating Strategies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ..., Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission. Telephone: 301-415-2963; e-mail... NUCLEAR REGULATORY COMMISSION [NRC-2011-0120] Notice of Issuance of Bulletin 2011-01, Mitigating Strategies AGENCY: U.S. Nuclear Regulatory Commission. ACTION: Notice of Issuance. SUMMARY: The U.S. Nuclear...

  15. 77 FR 45697 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0149] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending U.S. Nuclear... Budget and solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites...

  16. 77 FR 29697 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0066] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending U.S. Nuclear... Budget and solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites...

  17. 78 FR 76599 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-18

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of Renewal. SUMMARY: Pursuant to Section 14(a)(2)(A) of the Federal..., General Services Administration, notice is hereby given that the Nuclear Energy Advisory Committee (NEAC...

  18. 77 FR 67809 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). Federal Advisory Committee Act requires that public notice of these...

  19. Nuclear Energy Innovation Workshops. Executive Summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Allen, Todd; Jackson, John; Hildebrandt, Phil

    The nuclear energy innovation workshops were organized and conducted by INL on March 2-4, 2015 at the five NUC universities and Boise State University. The output from these workshops is summarized with particular attention to final summaries that were provided by technical leads at each of the workshops. The current revision includes 3-4 punctuation corrections and a correction of the month of release from May to June.

  20. Power conditioning for space nuclear reactor systems

    NASA Technical Reports Server (NTRS)

    Berman, Baruch

    1987-01-01

    This paper addresses the power conditioning subsystem for both Stirling and Brayton conversion of space nuclear reactor systems. Included are the requirements summary, trade results related to subsystem implementation, subsystem description, voltage level versus weight, efficiency and operational integrity, components selection, and shielding considerations. The discussion is supported by pertinent circuit and block diagrams. Summary conclusions and recommendations derived from the above studies are included.

  1. Licensed operating reactors: Status summary report, data as of December 31, 1995. Volume 20

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-06-01

    The US Nuclear Regulatory Commission`s monthly summary of licensed nuclear power reactor data is based primarily on the operating data report submitted by licensees for each unit. This report is divided into two sections: the first contains summary highlights and the second contains data on each individual unit in commercial operation. Section 1 availability factors, capacity factors, and forced outage rates are simple arithmetic averages. Section 2 items in the cumulative column are generally as reported by the licensees and notes to the use of weighted averages and starting dates other than commercial operation are provided.

  2. 78 FR 77606 - Security Requirements for Facilities Storing Spent Nuclear Fuel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... regulatory basis; availability of responses to public comments. SUMMARY: The U.S. Nuclear Regulatory... to Carol Gallagher; telephone: 301-287- 3422; email: [email protected] . For technical... Nuclear Security and Incident Response, U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001...

  3. 75 FR 67351 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  4. 78 FR 29125 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). Federal Advisory Committee Act (Pub. L. 94-463, 86 Stat. 770) requires...

  5. 76 FR 67717 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  6. 78 FR 70932 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Public Law No. 94-463, 86 Stat. 770...

  7. 75 FR 13269 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  8. 77 FR 26274 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-03

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. Law 92-463, 86 Stat. 770...

  9. Summary report on transportation of nuclear fuel materials in Japan : transportation infrastructure, threats identified in open literature, and physical protection regulations.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cochran, John Russell; Ouchi, Yuichiro; Furaus, James Phillip

    2008-03-01

    This report summarizes the results of three detailed studies of the physical protection systems for the protection of nuclear materials transport in Japan, with an emphasis on the transportation of mixed oxide fuel materials1. The Japanese infrastructure for transporting nuclear fuel materials is addressed in the first section. The second section of this report presents a summary of baseline data from the open literature on the threats of sabotage and theft during the transport of nuclear fuel materials in Japan. The third section summarizes a review of current International Atomic Energy Agency, Japanese and United States guidelines and regulations concerningmore » the physical protection for the transportation of nuclear fuel materials.« less

  10. United Campuses to Prevent Nuclear War: Nuclear War Course Summaries.

    ERIC Educational Resources Information Center

    Journal of College Science Teaching, 1983

    1983-01-01

    Briefly describes 46 courses on nuclear war available from United Campuses to Prevent Nuclear War (UCAM). These courses are currently being or have been taught at colleges/universities, addressing effects of nuclear war, arms race history, new weapons, and past arms control efforts. Syllabi (with assignments/reading lists) are available from UCAM.…

  11. Inspection of Nuclear Power Plant Containment Structures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Graves, H.L.; Naus, D.J.; Norris, W.E.

    1998-12-01

    Safety-related nuclear power plant (NPP) structures are designed to withstand loadings from a number of low-probability external and interval events, such as earthquakes, tornadoes, and loss-of-coolant accidents. Loadings incurred during normal plant operation therefore generally are not significant enough to cause appreciable degradation. However, these structures are susceptible to aging by various processes depending on the operating environment and service conditions. The effects of these processes may accumulate within these structures over time to cause failure under design conditions, or lead to costly repair. In the late 1980s and early 1990s several occurrences of degradation of NPP structures were discoveredmore » at various facilities (e.g., corrosion of pressure boundary components, freeze- thaw damage of concrete, and larger than anticipated loss of prestressing force). Despite these degradation occurrences and a trend for an increasing rate of occurrence, in-service inspection of the safety-related structures continued to be performed in a somewhat cursory manner. Starting in 1991, the U.S. Nuclear Regulatory Commission (USNRC) published the first of several new requirements to help ensure that adequate in-service inspection of these structures is performed. Current regulatory in-service inspection requirements are reviewed and a summary of degradation experience presented. Nondestructive examination techniques commonly used to inspect the NPP steel and concrete structures to identify and quantify the amount of damage present are reviewed. Finally, areas where nondestructive evaluation techniques require development (i.e., inaccessible portions of the containment pressure boundary, and thick heavily reinforced concrete sections are discussed.« less

  12. Radiochemistry and the Study of Fission

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rundberg, Robert S.

    These are slides from a lecture given at UC Berkeley. Radiochemistry has been used to study fission since its discovery. Radiochemical methods are used to determine cumulative mass yields. These measurements have led to the two-mode fission hypothesis to model the neutron energy dependence of fission product yields. Fission product yields can be used for the nuclear forensics of nuclear explosions. The mass yield curve depends on both the fuel and the neutron spectrum of a device. Recent studies have shown that the nuclear structure of the compound nucleus can affect the mass yield distribution. The following topics are covered:more » In the beginning: the discovery of fission; forensics using fission products: what can be learned from fission products, definitions of R-values and Q-values, fission bases, K-factors and fission chambers, limitations; the neutron energy dependence of the mass yield distribution (the two mode fission hypothesis); the influence of nuclear structure on the mass yield distribution. In summary: Radiochemistry has been used to study fission since its discovery. Radiochemical measurement of fission product yields have provided the highest precision data for developing fission models and for nuclear forensics. The two-mode fission hypothesis provides a description of the neutron energy dependence of the mass yield curve. However, data is still rather sparse and more work is needed near second and third chance fission. Radiochemical measurements have provided evidence for the importance of nuclear states in the compound nucleus in predicting the mass yield curve in the resonance region.« less

  13. Filopodia-like Actin Cables Position Nuclei in Association with Perinuclear Actin in Drosophila Nurse Cells

    PubMed Central

    Huelsmann, Sven; Ylänne, Jari; Brown, Nicholas H.

    2013-01-01

    Summary Controlling the position of the nucleus is vital for a number of cellular processes from yeast to humans. In Drosophila nurse cells, nuclear positioning is crucial during dumping, when nurse cells contract and expel their contents into the oocyte. We provide evidence that in nurse cells, continuous filopodia-like actin cables, growing from the plasma membrane and extending to the nucleus, achieve nuclear positioning. These actin cables move nuclei away from ring canals. When nurse cells contract, actin cables associate laterally with the nuclei, in some cases inducing nuclear turning so that actin cables become partially wound around the nuclei. Our data suggest that a perinuclear actin meshwork connects actin cables to nuclei via actin-crosslinking proteins such as the filamin Cheerio. We provide a revised model for how actin structures position nuclei in nurse cells, employing evolutionary conserved machinery. PMID:24091012

  14. Epstein-Barr Viral Productive Amplification Reprograms Nuclear Architecture, DNA Replication and Histone Deposition

    PubMed Central

    Chiu, Ya-Fang; Sugden, Arthur U.; Sugden, Bill

    2014-01-01

    Summary The spontaneous transition of Epstein-Barr Virus (EBV) from latency to productive infection is infrequent, making its analysis in the resulting mixed cell populations difficult. We engineered cells to support this transition efficiently and developed EBV DNA variants that could be visualized and measured as fluorescent signals over multiple cell cycles. This approach revealed that EBV’s productive replication began synchronously for viral DNAs within a cell but asynchronously between cells. EBV DNA amplification was delayed until early S-phase and occurred in factories characterized by the absence of cellular DNA and histones, by a sequential redistribution of PCNA, and by localization away from the nuclear periphery. The earliest amplified DNAs lacked histones accompanying a decline in four histone chaperones. Thus, EBV transitions from being dependent on the cellular replication machinery during latency to commandeering both that machinery and nuclear structure for its own reproductive needs. PMID:24331459

  15. 75 FR 53685 - Blue Ribbon Commission on America's Nuclear Future

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Blue Ribbon Commission on America's Nuclear Future (the Commission). The Commission was...

  16. 76 FR 71334 - Blue Ribbon Commission on America's Nuclear Future

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Blue Ribbon Commission on America's Nuclear Future (the Commission). The Commission was...

  17. 75 FR 65465 - Blue Ribbon Commission on America's Nuclear Future, Disposal Subcommittee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future, Disposal Subcommittee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This... subcommittee of the Blue Ribbon Commission on America's Nuclear Future (the Commission). The establishment of...

  18. 77 FR 62538 - Advisory Committee on the Medical Uses of Isotopes: Call for Nominations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ...) nuclear medicine physicist; (d) therapy medical physicist; (e) radiation safety officer; (f) nuclear... NUCLEAR REGULATORY COMMISSION Advisory Committee on the Medical Uses of Isotopes: Call for Nominations AGENCY: U.S. Nuclear Regulatory Commission. ACTION: Call for nominations. SUMMARY: The U.S...

  19. 76 FR 46856 - Qualification of Connection Assemblies for Nuclear Power Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... Power Plants AGENCY: Nuclear Regulatory Commission. ACTION: Regulatory guide; issuance. SUMMARY: The U.S..., ``Qualification of Connection Assemblies for Nuclear Power Plants.'' This guide describes a method that the NRC... in nuclear power plants. The environmental qualification helps ensure that connection assemblies can...

  20. 78 FR 716 - DOE/NSF Nuclear Science Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ... DEPARTMENT OF ENERGY DOE/NSF Nuclear Science Advisory Committee AGENCY: Office of Science, DOE. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the DOE/NSF Nuclear Science... Energy and the National Science Foundation on scientific priorities within the field of basic nuclear...

  1. 76 FR 78252 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of Renewal. SUMMARY: Pursuant to Section 14(a)(2)(A) of the Federal... hereby given that the Nuclear Energy Advisory Committee will be renewed for a two-year period. The...

  2. Structural materials for Gen-IV nuclear reactors: Challenges and opportunities

    NASA Astrophysics Data System (ADS)

    Murty, K. L.; Charit, I.

    2008-12-01

    Generation-IV reactor design concepts envisioned thus far cater toward a common goal of providing safer, longer lasting, proliferation-resistant and economically viable nuclear power plants. The foremost consideration in the successful development and deployment of Gen-IV reactor systems is the performance and reliability issues involving structural materials for both in-core and out-of-core applications. The structural materials need to endure much higher temperatures, higher neutron doses and extremely corrosive environment, which are beyond the experience of the current nuclear power plants. Materials under active consideration for use in different reactor components include various ferritic/martensitic steels, austenitic stainless steels, nickel-base superalloys, ceramics, composites, etc. This paper presents a summary of various Gen-IV reactor concepts, with emphasis on the structural materials issues depending on the specific application areas. This paper also discusses the challenges involved in using the existing materials under both service and off-normal conditions. Tasks become increasingly complex due to the operation of various fundamental phenomena like radiation-induced segregation, radiation-enhanced diffusion, precipitation, interactions between impurity elements and radiation-produced defects, swelling, helium generation and so forth. Further, high temperature capability (e.g. creep properties) of these materials is a critical, performance-limiting factor. It is demonstrated that novel alloy and microstructural design approaches coupled with new materials processing and fabrication techniques may mitigate the challenges, and the optimum system performance may be achieved under much demanding conditions.

  3. 75 FR 36647 - Blue Ribbon Commission on America's Nuclear Future

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future AGENCY: Office of Nuclear Energy, DOE. ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Blue... directed that the Blue Ribbon Commission on America's Nuclear Future (the Commission) be established to...

  4. 76 FR 5354 - Public Availability of Defense Nuclear Facilities Safety Board FY 2010 Service Contract Inventory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Public Availability of Defense Nuclear Facilities Safety Board FY 2010 Service Contract Inventory AGENCY: Defense Nuclear Facilities Safety Board (Board). ACTION: Notice of public availability of FY 2010 Service Contract Inventories. SUMMARY: In accordance with...

  5. Potential Nuclear Conflict: Attention Adult Educators.

    ERIC Educational Resources Information Center

    Gleazer, Edmund J.

    1983-01-01

    Teaching about potential nuclear conflict is increasing in schools, colleges, and universities. A group of faculty from many universities across the United States has formed United Campuses to Prevent Nuclear War (UCAM) to produce teaching materials and publish summaries of courses on nuclear war. One such course at Lafayette College…

  6. 76 FR 1608 - Blue Ribbon Commission on America's Nuclear Future

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open...- 0544; e-mail [email protected]nuclear.energy.gov . Additional information may also be available at http...

  7. 75 FR 35000 - Blue Ribbon Commission on America's Nuclear Future, Disposal Subcommittee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future, Disposal Subcommittee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of Open Meeting. SUMMARY: This... Avenue, SW., Washington DC 20585, e-mail to [email protected]nuclear.energy.gov , or post comments on the...

  8. 75 FR 25850 - Blue Ribbon Commission on America's Nuclear Future

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    ... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open...-4243 or facsimile (202) 586- 0544; e-mail [email protected]nuclear.energy.gov . Additional information may...

  9. 75 FR 10791 - Blue Ribbon Commission on America's Nuclear Future

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open...; telephone (202) 586-4243 or facsimile (202) 586- 0544; e-mail [email protected]nuclear.energy.gov...

  10. 75 FR 51247 - Blue Ribbon Commission on America's Nuclear Future, Disposal Subcommittee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future, Disposal Subcommittee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This...; telephone (202) 586-4243 or facsimile (202) 586- 0544; e-mail [email protected]nuclear.energy.gov . Additional...

  11. 77 FR 64562 - Draft Emergency Preparedness Frequently Asked Questions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0248] Draft Emergency Preparedness Frequently Asked... Nuclear Regulatory Commission. Mark Thaggard, Deputy Director for Emergency Preparedness, Division of... comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is making available for comment Emergency...

  12. 76 FR 76192 - NRC Enforcement Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... NUCLEAR REGULATORY COMMISSION [NRC-2011-0273] NRC Enforcement Policy AGENCY: Nuclear Regulatory Commission. ACTION: Proposed enforcement policy revision; request for comment. SUMMARY: The U.S. Nuclear... licensees, vendors, and contractors), on proposed revisions to the NRC's Enforcement Policy (the Policy) and...

  13. 78 FR 73897 - SHINE Medical Technologies, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 50-608; NRC-2013-0053] SHINE Medical Technologies, Inc. AGENCY: Nuclear Regulatory Commission. ACTION: License application; docketing. SUMMARY: The U.S. Nuclear... construction permit, submitted by SHINE Medical Technologies, Inc. (SHINE) is acceptable for docketing...

  14. 77 FR 34194 - Advance Notification to Native American Tribes of Transportation of Certain Types of Nuclear Waste

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... NUCLEAR REGULATORY COMMISSION 10 CFR Parts 71 and 73 RIN 3150-AG41 [NRC-1999-0005] Advance Notification to Native American Tribes of Transportation of Certain Types of Nuclear Waste AGENCY: Nuclear Regulatory Commission. ACTION: Final rule. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is amending...

  15. 77 FR 66650 - Proposed Revisions to Radiation Protection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0268] Proposed Revisions to Radiation Protection AGENCY: Nuclear Regulatory Commission. ACTION: Standard review plan-draft section revision; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the Commission) is revising the following sections...

  16. 77 FR 6827 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-09

    ... NUCLEAR REGULATORY COMMISSION [NRC-2011-0280] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC action to... public comment. SUMMARY: The Nuclear Regulatory Commission (NRC) invites public comment about our...

  17. 77 FR 51943 - Procedures for Safety Investigations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1708 Procedures for Safety Investigations AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Proposed rule; extension of comment period. SUMMARY: The Defense Nuclear Facilities Safety Board is extending the time for comments on its proposed...

  18. Nuclear Winter: Uncertainties Surround the Long-Term Effects of Nuclear War. Report to the Congress.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    Nuclear winter, a term used to describe potential long-term climate and environmental effects of nuclear war, has been a subject of debate and controversy. This report examines and presents scientific and policy implications of nuclear winter. Contents include: (1) an executive summary (highlighting previous and current studies on the topic); (2)…

  19. 78 FR 66785 - Luminant Generation Company, LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 52-034 and 52-035; NRC-2008-0594] Luminant Generation Company, LLC AGENCY: Nuclear Regulatory Commission. ACTION: Notice of receipt; availability. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is giving notice once each week for four consecutive weeks...

  20. 77 FR 70192 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0263] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  1. 76 FR 72982 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2011-0271] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  2. 77 FR 69661 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0230] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  3. 78 FR 70353 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2013-0248] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  4. 77 FR 21813 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0058] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  5. 77 FR 58872 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0198] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  6. 78 FR 66078 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2013-0238] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  7. 78 FR 42112 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2013-0116] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  8. 78 FR 28244 - Agency Information Collection Activities; Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2013-0085] Agency Information Collection Activities; Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  9. 77 FR 44289 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0150] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  10. 77 FR 5279 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0009] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The Nuclear Regulatory Commission (NRC) invites public comment about...

  11. 76 FR 72983 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2011-0250] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  12. 77 FR 54617 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0184] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  13. 76 FR 33788 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2011-0009] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... (OMB) and solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites...

  14. 77 FR 44290 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0155] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  15. 77 FR 48555 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0172] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  16. 76 FR 17627 - Sunshine Act Meeting Postponed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Meeting Postponed AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice of public meeting postponement. SUMMARY: The Defense Nuclear Facilities Safety Board (Board) published a document in the Federal Register of March 3, 2011 (76 FR 11764...

  17. 78 FR 79500 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2013-0279] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) invites public comment...

  18. 77 FR 12089 - Proposed Generic Communication; Regulatory Issue Summary 2012-XX: Developing Inservice Testing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0048] Proposed Generic Communication; Regulatory Issue... CFR) Part 52, ``Licenses, Certifications, and Approvals for Nuclear Power Plants,'' to satisfy the... inservice testing programs during the initial 120-month program interval following nuclear power plant...

  19. 77 FR 63893 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0228] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of pending NRC... solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the Commission) invites...

  20. 75 FR 27228 - Proposed FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 Proposed FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice of proposed rulemaking. SUMMARY: Pursuant to 10 CFR 1703.107(b)(6) of the Board's regulations, the Defense Nuclear Facilities Safety Board is...

  1. 77 FR 41258 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to...

  2. 76 FR 28194 - Proposed FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-16

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 Proposed FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice of proposed rulemaking. SUMMARY: Pursuant to 10 CFR 1703.107(b)(6) of the Board's regulations, the Defense Nuclear Facilities Safety Board is...

  3. 76 FR 43819 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to...

  4. 78 FR 20625 - Extension of Hearing Record Closure Date

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Extension of Hearing Record Closure Date AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Extension of hearing record closure date. SUMMARY: The Defense Nuclear Facilities Safety Board (Board) published a document in the Federal Register on January 22, 2013...

  5. 77 FR 65871 - Extension of Hearing Record Closure Date

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Extension of Hearing Record Closure Date AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Extension of hearing record closure date. SUMMARY: The Defense Nuclear Facilities Safety Board (Board) published a document in the Federal Register on August 15, 2012...

  6. 78 FR 1206 - Second Extension of Hearing Record Closure Date

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Second Extension of Hearing Record Closure Date AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Second extension of hearing record closure date. SUMMARY: The Defense Nuclear Facilities Safety Board (Board) published a document in the Federal Register on...

  7. 78 FR 69140 - CSMI, LLC; Request for Action

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2013-0250] CSMI, LLC; Request for Action AGENCY: Nuclear Regulatory Commission. ACTION: Request for action; receipt. SUMMARY: The U.S. Nuclear Regulatory... petitioner) has requested that the NRC take action with regard to CSMI. The petitioner's requests are...

  8. JPRS Report, China, Handbook of Military Knowledge for Commanders

    DTIC Science & Technology

    1988-03-07

    Chemical and Biological Weapons Chapter I Nuclear Weapons (178) A. Summary Statement on Nuclear Weapons (178) 1. Basic Principles of Nuclear...199) 1. Basic Principles of Protection Against Nuclear, Chemical and Biological Weapons* (199) 2. Maior Actions For Protection Against Nuclear...people’s bodies through the digestive tract. Skin contact. Biological warfare agents may enter the body directly through the skin , mucous membranes or

  9. Transcriptional Control by PARP-1: Chromatin Modulation, Enhancer-binding, Coregulation, and Insulation

    PubMed Central

    Kraus, W. Lee

    2008-01-01

    Summary The regulation of gene expression requires a wide array of protein factors that can modulate chromatin structure, act at enhancers, function as transcriptional coregulators, or regulate insulator function. Poly(ADP-ribose) polymerase-1 (PARP-1), an abundant and ubiquitous nuclear enzyme that catalyzes the NAD+-dependent addition of ADP-ribose polymers on a variety of nuclear proteins, has been implicated in all of these functions. Recent biochemical, genomic, proteomic, and cell-based studies have highlighted the role of PARP-1 in each of these processes and provided new insights about the molecular mechanisms governing PARP-1-dependent regulation of gene expression. In addition, these studies have demonstrated how PARP-1 functions as an integral part of cellular signaling pathways that culminate in gene regulatory outcomes. PMID:18450439

  10. The Great Nuclear Power Debate (1)--A Summary

    ERIC Educational Resources Information Center

    Douglas, John H.

    1976-01-01

    Five issues concerning nuclear power--economics, danger from accidents, environmental effects, terrorism, and alternatives are debated, with one paragraph statements from opponents and advocates on each of the topics. (CP)

  11. Summary of sessions on nuclear astrophysics

    NASA Astrophysics Data System (ADS)

    Rolfs, C.

    In the minds of some there exists the patronizing belief that nuclear physics is a mature science. The same is not believed about nuclear astrophysics, which has been an active branch of astrophysics for over fifty years, but is now in the midst of an exciting revival in experimental and theoretical research around the world. The ultimate goal is to understand how nuclear processes generate the energy of stars over their lifetimes and, in doing so, synthesize heavier elements from the primordial hydrogen and helium produced in the Big Bang, which led to the expanding universe. Impressive progress has been made in this goal and this was rewarded. However, there are major puzzles, such as the solar neutrino problem to name just one, which challenge the fundaments of the field. To solve these problems, new nuclear physics data are needed employing novel experimental techniques such as radioactive ion beams and underground accelerator facilities. Without such new data, much of the work done so far will - in an optimistic view - be incomplete and - in a pessimistic view - be possibly wrong. Thus, new data do not represent a fine structure information or a cleaning-up job, but they represent the major next step in this exciting field&

  12. 78 FR 28652 - Advisory Committee on the Medical Uses of Isotopes: Call for Nominations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ...; (d) therapy physicist; (e) radiation safety officer; (f) nuclear pharmacist; (g) two radiation... NUCLEAR REGULATORY COMMISSION Advisory Committee on the Medical Uses of Isotopes: Call for Nominations AGENCY: U.S. Nuclear Regulatory Commission. ACTION: Call for Nominations. SUMMARY: The U.S...

  13. 76 FR 24831 - Alternative to Minimum Days Off Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... NUCLEAR REGULATORY COMMISSION 10 CFR Part 26 RIN 3150-AI94 [NRC-2011-0058] Alternative to Minimum Days Off Requirements AGENCY: Nuclear Regulatory Commission. ACTION: Proposed rule; correction. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is correcting a proposed rule that appeared in the...

  14. 78 FR 65978 - Draft Revised Strategic Plan for FY 2014-2018

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Draft Revised Strategic Plan for FY 2014-2018 AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice. SUMMARY: In accordance with Office of Management and Budget Circular No. A-11, the Defense Nuclear Facilities Safety Board (DNFSB) is soliciting...

  15. 75 FR 4794 - Draft Revised Strategic Plan for FY 2010-2015

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Draft Revised Strategic Plan for FY 2010-2015 AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice. SUMMARY: In accordance with OMB Circular No. A-11, the Defense Nuclear Facilities Safety Board is soliciting comments from all interested and potentially...

  16. 78 FR 16601 - List of Approved Spent Fuel Storage Casks: MAGNASTOR® System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... Storage Casks: MAGNASTOR[supreg] System AGENCY: Nuclear Regulatory Commission. ACTION: Direct final rule. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is amending its spent fuel storage regulations by revising the NAC International, Inc. (NAC) Modular Advanced Generation Nuclear All-purpose Storage...

  17. 77 FR 19278 - Informational Meeting on Nuclear Fuel Cycle Options

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... DEPARTMENT OF ENERGY Informational Meeting on Nuclear Fuel Cycle Options AGENCY: Office of Fuel Cycle Technologies, Office of Nuclear Energy, Department of Energy. ACTION: Notice of meeting. SUMMARY: The Office of Fuel Cycle Technologies will be hosting a one- day informational meeting at the Argonne...

  18. 76 FR 62050 - DOE/NSF Nuclear Science Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... DEPARTMENT OF ENERGY DOE/NSF Nuclear Science Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of renewal. SUMMARY: Pursuant to Section 14(a)(2)(A) of the Federal... Services Administration, notice is hereby given that the DOE/NSF Nuclear Science Advisory Committee (NSAC...

  19. Summary Report for the Radiation Detection for Nuclear Security Summer School 2014

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Runkle, Robert C.; Baciak, James E.; Woodring, Mitchell L.

    Executive Summary The Pacific Northwest National Laboratory (PNNL) hosted students from across the United States at the 3rd Radiation Detection for Nuclear Security Summer School from 16 – 27 June 2014. The summer school provided students with a unique understanding of nuclear security challenges faced in the field and exposed them to the technical foundations, analyses, and insight that will be required by future leaders in technology development and implementation. The course heavily emphasized laboratory and field demonstrations including direct measurements of special nuclear material. Student evaluations and feedback from student advisors indicates that the summer school achieved its objectivesmore » of 1) exposing students to the range of nuclear security applications for which radiation detection is necessary, 2) articulating the relevance of student research into the broader context, and 3) exciting students about the possibility of future careers in nuclear security. In fact, we are beginning to see previous students both enroll in graduate programs (former undergraduates) and complete internships at agencies like the National Nuclear Security Administration.« less

  20. Russian Compliance with the Intermediate Range Nuclear Forces (INF) Treaty: Background and Issues for Congress

    DTIC Science & Technology

    2017-01-27

    Russian Compliance with the Intermediate Range Nuclear Forces (INF) Treaty: Background and Issues for Congress Amy F. Woolf Specialist in... Nuclear Weapons Policy January 27, 2017 Congressional Research Service 7-5700 www.crs.gov R43832 Russian Compliance with the Intermediate Range... Nuclear Forces (INF) Treaty Congressional Research Service Summary The United States and Soviet Union signed the Intermediate-Range Nuclear Forces

  1. 76 FR 40755 - Impact of Reduced Dose Limits on NRC Licensed Activities; Solicitation of Public Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... NUCLEAR REGULATORY COMMISSION [NRC-2009-0279] Impact of Reduced Dose Limits on NRC Licensed Activities; Solicitation of Public Comment AGENCY: Nuclear Regulatory Commission. ACTION: Solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or Commission) is seeking public...

  2. 78 FR 11686 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0230] Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory.... SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review the...

  3. 76 FR 76327 - Installation of Radiation Alarms for Rooms Housing Neutron Sources

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... NUCLEAR REGULATORY COMMISSION 10 CFR Part 73 [Docket Nos. PRM-73-15; NRC-2011-0251] Installation of Radiation Alarms for Rooms Housing Neutron Sources AGENCY: Nuclear Regulatory Commission. ACTION: Petition for rulemaking; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the...

  4. 78 FR 11686 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0263] Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory.... SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review the...

  5. 76 FR 77560 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2011-0181] Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory.... SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review the...

  6. 77 FR 15398 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2011-0271] Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory.... SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review the...

  7. 78 FR 63249 - OMB Agency Information Collection Activities: Submission for the Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2013-0116] OMB Agency Information Collection Activities: Submission for the Office of Management and Budget Review; Comment Request AGENCY: Nuclear... comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review...

  8. 76 FR 50767 - Southern Nuclear Operating Co., et al.; Combined Licenses for Vogtle Electric Generating Plant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... Limited Work Authorizations AGENCY: Nuclear Regulatory Commission. ACTION: Notice of hearing. SUMMARY: The... Southern Nuclear Operating Company for two combined licenses (COLs) seeking approval to construct and...), as well as for two limited work authorizations (LWAs) to engage in selected construction activities...

  9. 78 FR 59073 - Pacific Gas and Electric Company; Humboldt Bay Independent Spent Fuel Storage Installation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... AGENCY: Nuclear Regulatory Commission. ACTION: License amendment application; issuance. SUMMARY: The U.S...: 301-287- 3422; email: [email protected] . For technical questions, contact the individual(s...: Chris Allen, Office of Nuclear Material Safety and Safeguards, U.S. Nuclear Regulatory Commission...

  10. 78 FR 63501 - Request To Submit a Two-Part Application-Northwest Medical Isotopes, LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... NUCLEAR REGULATORY COMMISSION [Project No. 0803; NRC-2013-0235] Request To Submit a Two-Part Application--Northwest Medical Isotopes, LLC AGENCY: Nuclear Regulatory Commission. ACTION: Exemption. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is issuing an exemption in response to an August 9, 2013...

  11. 75 FR 34439 - Defense Science Board Task Force on Nuclear Treaty Monitoring and Verification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... DEPARTMENT OF DEFENSE Office of the Secretary Defense Science Board Task Force on Nuclear Treaty... meetings. SUMMARY: The Defense Science Board Task Force on Nuclear Treaty Monitoring and Verification will... Applications International Corporation, 4001 North Fairfax Drive, Suite 300, Arlington, VA. FOR FURTHER...

  12. 77 FR 12624 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2011-0263] Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory.... SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review the...

  13. 77 FR 69662 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0172] Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory.... SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review the...

  14. 77 FR 69663 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2012-0155] Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory.... SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review the...

  15. 76 FR 44963 - Advisory Committee on the Medical Uses of Isotopes: Call for Nominations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... byproduct material; (d) therapy physicist; (e) radiation safety officer; (f) nuclear pharmacist; (g) two... NUCLEAR REGULATORY COMMISSION Advisory Committee on the Medical Uses of Isotopes: Call for Nominations AGENCY: U.S. Nuclear Regulatory Commission. ACTION: Call for Nominations. SUMMARY: The U.S...

  16. 78 FR 70588 - STP Nuclear Operating Company; South Texas Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... efficiency; (8) wind power; (9) solar power; (10) hydroelectric power; (11) ocean wave and current energy... generic environmental impact statement for license renewal of nuclear plants; issuance. SUMMARY: Notice is hereby given that the U.S. Nuclear Regulatory Commission (NRC) has published the final, plant-specific...

  17. 77 FR 22361 - Energy Northwest, Columbia Generating Station; Final Supplement 47 to the Generic Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ...) solar power; (9) wind power; (10) biomass waste; (11) hydroelectric power; (12) ocean wave and current... Nuclear Plants AGENCY: Nuclear Regulatory Commission. ACTION: Final Supplement 47 to the Generic Environmental Impact Statement for License Renewal of Nuclear Plants; issuance. SUMMARY: Notice is hereby given...

  18. 75 FR 14212 - Proposed Generic Communications; Applicability of 10 CFR Part 21 Requirements to Applicants for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0122] Proposed Generic Communications; Applicability of 10 CFR Part 21 Requirements to Applicants for Standard Design Certifications AGENCY: Nuclear Regulatory Commission. ACTION: Notice of opportunity for public comment. SUMMARY: The U.S. Nuclear Regulatory Commission...

  19. 78 FR 4404 - DOE Response to Recommendation 2012-2 of the Defense Nuclear Facilities Safety Board, Hanford...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... DEPARTMENT OF ENERGY DOE Response to Recommendation 2012-2 of the Defense Nuclear Facilities Safety Board, Hanford Tank Farms Flammable Gas Safety Strategy AGENCY: Department of Energy. ACTION: Notice. SUMMARY: On September 28, 2012 the Defense Nuclear Facilities Safety Board submitted...

  20. 76 FR 44865 - Domestic Licensing of Source Material-Amendments/Integrated Safety Analysis

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... NUCLEAR REGULATORY COMMISSION 10 CFR Part 40 RIN 3150-AI50 [NRC-2009-0079 and NRC-2011-0080] Domestic Licensing of Source Material--Amendments/Integrated Safety Analysis AGENCY: Nuclear Regulatory Commission. ACTION: Extension of public comment period and public meeting. SUMMARY: The U.S. Nuclear...

  1. International nuclear fuel cycle fact book. [Contains glossary of organizations, facilities, technical and other terms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-09-01

    The International Nuclear Fuel Cycle Fact Book has been compiled in an effort to provide current data concerning fuel cycle and waste management facilities, R D programs and key personnel on 23 countries, including the US, four multi-national agencies, and 21 nuclear societies. The Fact Book is organized as follows: National summaries-a section for each country which summarizes nuclear policy, describes organizational relationships, and provides addresses and names of key personnel and information on facilities. International agencies-a section for each of the international agencies which has significant fuel cycle involvement and a listing of nuclear societies. Glossary-a list of abbreviations/acronymsmore » of organizations, facilities, technical and other terms. The national summaries, in addition to the data described above, feature a small map for each country as well as some general information. The latter presented from the perspective of the Fact Book user in the United States.« less

  2. Historically Black Colleges and Universities Nuclear Energy Training Program: Summary of program activities, fiscal year 1986

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1987-04-27

    The Historically Black Colleges and Universities Nuclear Energy Training (HBCU NET) Program, funded by DOE, Office of Nuclear Energy and administered by ORAU, began in February 1984. The program provides support for training, study, research participation, and academic enrichment of students and faculty at designated HBCUs in nuclear science, nuclear engineering, and other nuclear-related technologes and disciplines. The program is composed of undergraduate scholarships, graduate fellowships, student and faculty research participation, and an annual student training institute.

  3. 76 FR 12373 - Notice of Availability of Final Supplement to the Environmental Assessment for the Proposed Pa...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 30-36974; NRC-2010-0374] Notice of Availability of Final... AGENCY: Nuclear Regulatory Commission. ACTION: Notice of availability. SUMMARY: Notice is hereby given that the U.S. Nuclear Regulatory Commission (NRC) has published a Final Supplement to the Environmental...

  4. 76 FR 50500 - Request for Comments on the Draft Policy Statement on Volume Reduction and Low-Level Radioactive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... NUCLEAR REGULATORY COMMISSION [NRC-2011-0183] Request for Comments on the Draft Policy Statement on Volume Reduction and Low-Level Radioactive Waste Management AGENCY: Nuclear Regulatory Commission. ACTION: Request for public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is revising its...

  5. 75 FR 43943 - Defense Science Board; Task Force on Nuclear Treaty Monitoring and Verification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... DEPARTMENT OF DEFENSE Office of the Secretary Defense Science Board; Task Force on Nuclear Treaty... meetings. SUMMARY: The Defense Science Board Task Force on Nuclear Treaty Monitoring and Verification will... held September 13-14, and 25-26, 2010. ADDRESSES: The meetings will be held at Science Applications...

  6. 77 FR 9273 - WORKSHOP Sponsored by the Nuclear Regulatory Commission and the Electric Power Research Institute...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... Commission and the Electric Power Research Institute on the Treatment of Probabilistic Risk Assessment.... SUMMARY: The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research (RES), in cooperation with the Electric Power Research Institute (EPRI), will hold a joint workshop on the Treatment of...

  7. 78 FR 15383 - Approval of Direct Transfer of Licenses and Issuance of License Amendment To Effectuate Such...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-11

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 70-7003 and 70-7004; NRC-2010-0355] Approval of Direct... Operating, LLC AGENCY: Nuclear Regulatory Commission. ACTION: Notice of approval of direct transfer of control and issuance of license amendments to effectuate such transfers. SUMMARY: The U.S. Nuclear...

  8. 77 FR 43583 - DOE Response to Recommendation 2012-1 of the Defense Nuclear Facilities Safety Board, Savannah...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... DEPARTMENT OF ENERGY DOE Response to Recommendation 2012-1 of the Defense Nuclear Facilities Safety Board, Savannah River Site Building 235-F Safety AGENCY: Department of Energy. ACTION: Notice. SUMMARY: On May 8, 2012, the Defense Nuclear Facilities Safety Board submitted Recommendation 2012-1...

  9. 75 FR 51025 - Blue Ribbon Commission on America's Nuclear Future, Reactor and Fuel Cycle Technology Subcommittee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... DEPARTMENT OF ENERGY Blue Ribbon Commission on America's Nuclear Future, Reactor and Fuel Cycle... meeting. SUMMARY: This notice announces an open meeting of the Reactor and Fuel Cycle Technology (RFCT... back end of the nuclear fuel cycle. The Commission will provide advice and make recommendations on...

  10. International nuclear waste management fact book

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abrahms, C W; Patridge, M D; Widrig, J E

    1995-11-01

    The International Nuclear Waste Management Fact Book has been compiled to provide current data on fuel cycle and waste management facilities, R and D programs, and key personnel in 24 countries, including the US; four multinational agencies; and 20 nuclear societies. This document, which is in its second year of publication supersedes the previously issued International Nuclear Fuel Cycle Fact Book (PNL-3594), which appeared annually for 12 years. The content has been updated to reflect current information. The Fact Book is organized as follows: National summaries--a section for each country that summarizes nuclear policy, describes organizational relationships, and provides addressesmore » and names of key personnel and information on facilities. International agencies--a section for each of the international agencies that has significant fuel cycle involvement and a list of nuclear societies. Glossary--a list of abbreviations/acronyms of organizations, facilities, and technical and other terms. The national summaries, in addition to the data described above, feature a small map for each country and some general information that is presented from the perspective of the Fact Book user in the US.« less

  11. Emergency Support Function 15 Standard Operating Procedures

    DTIC Science & Technology

    2013-08-01

    learned from numerous incidents to include the BP oil spill, the Fukushima nuclear incident, Hurricane Sandy and the Boston Marathon attack. Guidance is...Staffing  Operations  Activation  Incident Operations  Case Study - 2013 Boston Marathon Bombing  Case Study - 2011 Fukushima Nuclear Crisis...Quick Summary  Radiological Dispersal Device (RDD)  Improvised Nuclear Device (IND)  Federal Response  Case Studies – 2011 Fukushima Nuclear

  12. Current experiments in elementary particle physics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wohl, C.G.; Armstrong, F.E., Oyanagi, Y.; Dodder, D.C.

    1987-03-01

    This report contains summaries of 720 recent and current experiments in elementary particle physics (experiments that finished taking data before 1980 are excluded). Included are experiments at Brookhaven, CERN, CESR, DESY, Fermilab, Moscow Institute of Theoretical and Experimental Physics, Tokyo Institute of Nuclear Studies, KEK, LAMPF, Leningrad Nuclear Physics Institute, Saclay, Serpukhov, SIN, SLAC, and TRIUMF, and also experiments on proton decay. Instructions are given for searching online the computer database (maintained under the SLAC/SPIRES system) that contains the summaries. Properties of the fixed-target beams at most of the laboratories are summarized.

  13. 76 FR 70768 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... perform a probabilistic risk evaluation using the guidance contained in NRC approved NEI [Nuclear Energy... Issue Summary 2003-18, Supplement 2, ``Use of Nuclear Energy Institute (NEI) 99-01, Methodology for...

  14. National briefing summaries: Nuclear fuel cycle and waste management

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schneider, K.J.; Bradley, D.J.; Fletcher, J.F.

    Since 1976, the International Program Support Office (IPSO) at the Pacific Northwest Laboratory (PNL) has collected and compiled publicly available information concerning foreign and international radioactive waste management programs. This National Briefing Summaries is a printout of an electronic database that has been compiled and is maintained by the IPSO staff. The database contains current information concerning the radioactive waste management programs (with supporting information on nuclear power and the nuclear fuel cycle) of most of the nations (except eastern European countries) that now have or are contemplating nuclear power, and of the multinational agencies that are active in radioactivemore » waste management. Information in this document is included for three additional countries (China, Mexico, and USSR) compared to the prior issue. The database and this document were developed in response to needs of the US Department of Energy.« less

  15. Minutes of the third annual meeting of the Panel on Reference Nuclear Data. [BNL, October 5, 1978

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burrows, T.W.; Stewart, L.; Coyne, J.J.

    1979-05-01

    The major activities of the meeting were as follows: welcome; organization, approval of minutes of the second meeting, and approval of agenda; review of nuclear data compilation and evaluation efforts (national and international efforts, master data files, publications); summary of 1977 panel meeting; definition of reference nuclear data; discussion of specific data needs and possible data center contributions (reactor physics, medicine and biology, controlled thermonuclear reactors and astrophysics); establishment of current interest and future direction of the panel; adjournment. Recommendations and action items are listed. Tables on nuclear data needs in applied physics, medicine and biology, and controlled thermonuclear reactorsmore » and astrophysics are presented. Appendixes include membership lists of various committees, summaries of publication activities, survey results, correspondence, and portions of the documents Proceedings of the Magnetic Fusion Energy Blanket and Shield Workshop and National Needs for Critically Evaluated Physical and Chemical Data. (RWR)« less

  16. Summaries of research projects for fiscal years 1996 and 1997, medical applications and biophysical research

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    The Medical Applications and Biophysical Research Division of the Office of Biological and Environmental Research supports and manages research in several distinct areas of science and technology. The projects described in this book are grouped by the main budgetary areas: General Life Sciences (structural molecular biology), Medical Applications (primarily nuclear medicine) and Measurement Science (analytical chemistry instrumentation), Environmental Management Science Program, and the Small Business Innovation Research Program. The research funded by this division complements that of the other two divisions in the Office of Biological and Environmental Research (OBER): Health Effects and Life Sciences Research, and Environmental Sciences. Mostmore » of the OBER programs are planned and administered jointly by the staff of two or all three of the divisions. This summary book provides information on research supported in these program areas during Fiscal Years 1996 and 1997.« less

  17. Estrogen-related receptor β (ERRβ) – renaissance receptor or receptor renaissance?

    PubMed Central

    Divekar, Shailaja D.; Tiek, Deanna M.; Fernandez, Aileen; Riggins, Rebecca B.

    2016-01-01

    Estrogen-related receptors (ERRs) are founding members of the orphan nuclear receptor (ONR) subgroup of the nuclear receptor superfamily. Twenty-seven years of study have yet to identify cognate ligands for the ERRs, though they have firmly placed ERRα and ERRγ at the intersection of cellular metabolism and oncogenesis. The pace of discovery for novel functions of ERRβ, however, has until recently been somewhat slower than that of its family members. ERRβ has also been largely ignored in summaries and perspectives of the ONR literature. Here, we provide an overview of established and emerging knowledge of ERRβ in mouse, man, and other species, highlighting unique aspects of ERRβ biology that set it apart from the other two estrogen-related receptors, with a focus on the impact of alternative splicing on the structure and function of this receptor. PMID:27507929

  18. Theory of the n = 2 levels in muonic helium-3 ions

    NASA Astrophysics Data System (ADS)

    Franke, Beatrice; Krauth, Julian J.; Antognini, Aldo; Diepold, Marc; Kottmann, Franz; Pohl, Randolf

    2017-12-01

    The present knowledge of Lamb shift, fine-, and hyperfine structure of the 2S and 2P states in muonic helium-3 ions is reviewed in anticipation of the results of a first measurement of several 2S → 2P transition frequencies in the muonic helium-3 ion, μ3He+. This ion is the bound state of a single negative muon μ- and a bare helium-3 nucleus (helion), 3He++. A term-by-term comparison of all available sources, including new, updated, and so far unpublished calculations, reveals reliable values and uncertainties of the QED and nuclear structure-dependent contributions to the Lamb shift and the hyperfine splitting. These values are essential for the determination of the helion rms charge radius and the nuclear structure effects to the hyperfine splitting in μ3He+. With this review we continue our series of theory summaries in light muonic atoms [see A. Antognini et al., Ann. Phys. 331, 127 (2013); J.J. Krauth et al., Ann. Phys. 366, 168 (2016); and M. Diepold et al. arXiv:1606.05231 (2016)].

  19. i-PI: A Python interface for ab initio path integral molecular dynamics simulations

    NASA Astrophysics Data System (ADS)

    Ceriotti, Michele; More, Joshua; Manolopoulos, David E.

    2014-03-01

    Recent developments in path integral methodology have significantly reduced the computational expense of including quantum mechanical effects in the nuclear motion in ab initio molecular dynamics simulations. However, the implementation of these developments requires a considerable programming effort, which has hindered their adoption. Here we describe i-PI, an interface written in Python that has been designed to minimise the effort required to bring state-of-the-art path integral techniques to an electronic structure program. While it is best suited to first principles calculations and path integral molecular dynamics, i-PI can also be used to perform classical molecular dynamics simulations, and can just as easily be interfaced with an empirical forcefield code. To give just one example of the many potential applications of the interface, we use it in conjunction with the CP2K electronic structure package to showcase the importance of nuclear quantum effects in high-pressure water. Catalogue identifier: AERN_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AERN_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: GNU General Public License, version 3 No. of lines in distributed program, including test data, etc.: 138626 No. of bytes in distributed program, including test data, etc.: 3128618 Distribution format: tar.gz Programming language: Python. Computer: Multiple architectures. Operating system: Linux, Mac OSX, Windows. RAM: Less than 256 Mb Classification: 7.7. External routines: NumPy Nature of problem: Bringing the latest developments in the modelling of nuclear quantum effects with path integral molecular dynamics to ab initio electronic structure programs with minimal implementational effort. Solution method: State-of-the-art path integral molecular dynamics techniques are implemented in a Python interface. Any electronic structure code can be patched to receive the atomic coordinates from the Python interface, and to return the forces and energy that are used to integrate the equations of motion. Restrictions: This code only deals with distinguishable particles. It does not include fermonic or bosonic exchanges between equivalent nuclei, which can become important at very low temperatures. Running time: Depends dramatically on the nature of the simulation being performed. A few minutes for short tests with empirical force fields, up to several weeks for production calculations with ab initio forces. The examples provided with the code run in less than an hour.

  20. 77 FR 14047 - Guidance for Decommissioning Planning During Operations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ...)-4014, ``Decommissioning Planning During Operations.'' This action is necessary to correct the NRC's... NUCLEAR REGULATORY COMMISSION [NRC-2011-0286] Guidance for Decommissioning Planning During Operations AGENCY: Nuclear Regulatory Commission. ACTION: Draft regulatory guide; correction. SUMMARY: The U...

  1. Pulmonary disorder and present nuclear denotation: A brief summary

    PubMed Central

    Wiwanitkit, Viroj

    2011-01-01

    There are many health effects caused by leaked radiation from damaged reactors of a nuclear power plant. However, the effect on pulmonary system is not reported much. Focusing on the present nuclear denotation crisis in Japan, it is wise to review on the specific issue of pulmonary disorder and nuclear denotation. Several disorders of interest, including malignancy and non-malignancy disorders, are mentioned in the literature. PMID:21760839

  2. Peripheral re-localization of constitutive heterochromatin advances its replication timing and impairs maintenance of silencing marks.

    PubMed

    Heinz, Kathrin S; Casas-Delucchi, Corella S; Török, Timea; Cmarko, Dusan; Rapp, Alexander; Raska, Ivan; Cardoso, M Cristina

    2018-05-10

    The replication of the genome is a highly organized process, both spatially and temporally. Although a lot is known on the composition of the basic replication machinery, how its activity is regulated is mostly unknown. Several chromatin properties have been proposed as regulators, but a potential role of the nuclear DNA position remains unclear. We made use of the prominent structure and well-defined heterochromatic landscape of mouse pericentric chromosome domains as a well-studied example of late replicating constitutive heterochromatin. We established a method to manipulate its nuclear position and evaluated the effect on replication timing, DNA compaction and epigenetic composition. Using time-lapse microscopy, we observed that constitutive heterochromatin, known to replicate during late S-phase, was replicated in mid S-phase when repositioned to the nuclear periphery. Out-of-schedule replication resulted in deficient post-replicative maintenance of chromatin modifications, namely silencing marks. We propose that repositioned constitutive heterochromatin was activated in trans according to the domino model of origin firing by nearby (mid S) firing origins. In summary, our data provide, on the one hand, a novel approach to manipulate nuclear DNA position and, on the other hand, establish nuclear DNA position as a novel mechanism regulating DNA replication timing and epigenetic maintenance.

  3. 78 FR 33862 - Draft Emergency Preparedness Frequently Asked Questions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0113] Draft Emergency Preparedness Frequently Asked... Commission. William Gott, Acting Deputy Director for Emergency Preparedness, Division of Preparedness and... comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is making available for comment Emergency...

  4. 76 FR 57980 - Senior Executive Service Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Senior Executive Service Performance Review Board AGENCY... the Defense Nuclear Facilities Safety Board (DNFSB) Senior Executive Service (SES) Performance Review... summary rating of the senior executive's performance, the executive's response, and the higher level...

  5. 77 FR 54570 - Senior Executive Service Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Senior Executive Service Performance Review Board AGENCY... the Defense Nuclear Facilities Safety Board (DNFSB) Senior Executive Service (SES) Performance Review.... The PRB shall review and evaluate the initial summary rating of the senior executive's performance...

  6. Stamps Tell the Story of Nuclear Energy.

    ERIC Educational Resources Information Center

    Angelo, Joseph A., Jr.

    This document provides a summary history of the individual scientists principally responsible for the development of nuclear physics and a survey of modern utilization of atomic energy. Identified throughout the booklet are postage stamps illustrating each individual and topic discussed. (SL)

  7. 78 FR 52579 - SHINE Medical Technologies, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 50-608; NRC-2013-0053] SHINE Medical Technologies, Inc. AGENCY: Nuclear Regulatory Commission. ACTION: Notice of receipt and availability. SUMMARY: The U.S... application for a construction permit, submitted by SHINE Medical Technologies, Inc. (SHINE). ADDRESSES...

  8. Current experiments in elementary particle physics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wohl, C.G.; Armstrong, F.E.; Trippe, T.G.

    1989-09-01

    This report contains summaries of 736 current and recent experiments in elementary particle physics (experiments that finished taking data before 1982 are excluded). Included are experiments at Brookhaven, CERN, CESR, DESY, Fermilab, Tokyo Institute of Nuclear Studies, Moscow Institute of Theoretical and Experimental Physics, Joint Institute for Nuclear Research (Dubna), KEK, LAMPF, Novosibirsk, PSI/SIN, Saclay, Serpukhov, SLAC, and TRIUMF, and also several underground experiments. Also given are instructions for searching online the computer database (maintained under the SLAC/SPIRES system) that contains the summaries. Properties of the fixed-target beams at most of the laboratories are summarized.

  9. Near-field environment/processes working group summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Murphy, W.M.

    1995-09-01

    This article is a summary of the proceedings of a group discussion which took place at the Workshop on the Role of Natural Analogs in Geologic Disposal of High-Level Nuclear Waste in San Antonio, Texas on July 22-25, 1991. The working group concentrated on the subject of the near-field environment to geologic repositories for high-level nuclear waste. The near-field environment may be affected by thermal perturbations from the waste, and by disturbances caused by the introduction of exotic materials during construction of the repository. This group also discussed the application of modelling of performance-related processes.

  10. Three-Dimensional RNA Structure of the Major HIV-1 Packaging Signal Region

    PubMed Central

    Stephenson, James D.; Li, Haitao; Kenyon, Julia C.; Symmons, Martyn; Klenerman, Dave; Lever, Andrew M.L.

    2013-01-01

    Summary HIV-1 genomic RNA has a noncoding 5′ region containing sequential conserved structural motifs that control many parts of the life cycle. Very limited data exist on their three-dimensional (3D) conformation and, hence, how they work structurally. To assemble a working model, we experimentally reassessed secondary structure elements of a 240-nt region and used single-molecule distances, derived from fluorescence resonance energy transfer, between defined locations in these elements as restraints to drive folding of the secondary structure into a 3D model with an estimated resolution below 10 Å. The folded 3D model satisfying the data is consensual with short nuclear-magnetic-resonance-solved regions and reveals previously unpredicted motifs, offering insight into earlier functional assays. It is a 3D representation of this entire region, with implications for RNA dimerization and protein binding during regulatory steps. The structural information of this highly conserved region of the virus has the potential to reveal promising therapeutic targets. PMID:23685210

  11. Summary of Structural Evaluation and Design Support for the Underground Nuclear Test Program.

    DTIC Science & Technology

    1979-07-01

    consider using API -5LX pipe as this pipe has been shown to have high ductility (better than A36). This pipe comes in several grades (X42, X46, X52 , X56, X60...X65, X70) with the grade number representing the yield strength (ksi) of the steel. Grades X42 and X52 are readily available while the higher yield...strength steels are less readily available. I believe X52 has certainly a high enough yield strength (52,000 psi) for your application and that even

  12. Opportunities and challenges for structural health monitoring of radioactive waste systems and structures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Giurgiutiu, Victor; Mendez Torres, Adrian E.

    2013-07-01

    Radioactive waste systems and structures (RWSS) are safety-critical facilities in need of monitoring over prolonged periods of time. Structural health monitoring (SHM) is an emerging technology that aims at monitoring the state of a structure through the use of networks of permanently mounted sensors. SHM technologies have been developed primarily within the aerospace and civil engineering communities. This paper addresses the issue of transitioning the SHM concept to the monitoring of RWSS and evaluates the opportunities and challenges associated with this process. Guided wave SHM technologies utilizing structurally-mounted piezoelectric wafer active sensors (PWAS) have a wide range of applications basedmore » on both propagating-wave and standing-wave methodologies. Hence, opportunities exist for transitioning these SHM technologies into RWSS monitoring. However, there exist certain special operational conditions specific to RWSS such as: radiation field, caustic environments, marine environments, and chemical, mechanical and thermal stressors. In order to address the high discharge of used nuclear fuel (UNF) and the limited space in the storage pools the U.S. the Department of Energy (DOE) has adopted a 'Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste' (January 2013). This strategy endorses the key principles that underpin the Blue Ribbon Commission's on America's Nuclear Future recommendations to develop a sustainable program for deploying an integrated system capable of transporting, storing, and disposing of UNF and high-level radioactive waste from civilian nuclear power generation, defense, national security, and other activities. This will require research to develop monitoring, diagnosis, and prognosis tools that can aid to establish a strong technical basis for extended storage and transportation of UNF. Monitoring of such structures is critical for assuring the safety and security of the nation's spent nuclear fuel until a national policy for closure of the nuclear fuel cycle is defined and implemented. In addition, such tools can provide invaluable and timely information for verification of the predicted mechanical performance of RWSS (e.g. concrete or steel barriers) during off-normal occurrence and accident events such as the tsunami and earthquake event that affected Fukushima Daiichi nuclear power plant. The ability to verify the conditions, health, and degradation behavior of RWSS over time by applying nondestructive testing (NDT) as well as development of nondestructive evaluation (NDE) tools for new degradation processes will become challenging. The paper discusses some of the challenges associated to verification and diagnosis for RWSS and identifies SHM technologies which are more readily available for transitioning into RWSS applications. Fundamental research objectives that should be considered for the transition of SHM technologies (e.g., radiation hardened piezoelectric materials) for RWSS applications are discussed. The paper ends with summary, conclusions, and suggestions for further work. (authors)« less

  13. 75 FR 56999 - Senior Executive Service Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Senior Executive Service Performance Review Board AGENCY... the Defense Nuclear Facilities Safety Board (DNFSB) Senior Executive Service (SES) Performance Review... performance review boards. The PRB shall review and evaluate the initial summary rating of the senior...

  14. 324 Building spent fuel segments pieces and fragments removal summary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    SMITH, C L

    2003-01-09

    As part of the 324 Building Deactivation Project, all Spent Nuclear Fuel (SNF) and Special Nuclear Material were removed. The removal entailed packaging the material into a GNS-12 cask and shipping it to the Central Waste Complex (CWC).

  15. Justification and Persuasion about Cloning: Arguments in Hwang's Paper and Journalistic Reported Versions

    NASA Astrophysics Data System (ADS)

    Jiménez-Aleixandre, María Pilar; Federico-Agraso, Marta

    2009-05-01

    We examine the argumentative structure of Hwang et al.’s (2004) paper about human somatic cell nuclear transfer (SCNT, or ‘therapeutic cloning’), contrasted with four Journalistic Reported Versions (JRV) of it, and with students’ summaries of one JRV. As the evaluation of evidence is one of the critical features of argumentation (Jiménez-Aleixandre 2008), the analysis focuses on the use of evidence, drawing from instruments to analyze written argumentation (Kelly et al. 2008) and from studies about the structure of empirical research reports (Swales 2001). The objectives are: 1) To examine the use of evidence and the argumentative structure of Hwang et al.’s Science, 303: 1669-1674 (2004) original paper in terms of the criteria: a) pertinence of the evidence presented to the claims; b) sufficiency of the evidence for the purpose of supporting the claims; and c) coordination of the evidence across epistemic levels. 2) To explore how the structure of Hwang’s paper translates into the JRV and into university students’ perceptions about the evidence supporting the claims. The argumentative structure of Hwang’s paper is such that its apparently ostensible main claim about NT constitutes a justification for a second claim about its therapeutic applications, for which no evidence is offered. However, this second claim receives prominent treatment in the JRV and in the students’ summaries. Implications for promoting critical reading in the classroom are discussed.

  16. World Energy Data System (WENDS). Volume X. Nuclear facility profiles, PO--ZA. [Brief tabulated information

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1979-06-01

    In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then bymore » facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile.« less

  17. (Durability of building materials and components)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Naus, D.J.

    1990-11-27

    The traveler participated in the fourth meeting of RILEM 100-TSL, Techniques for Service Life Prediction,'' and The Fifth International Conference on Durability of Building Materials and Components.'' In addition, the traveler met with staff members at Taywood Engineering Ltd., Electricite de France, and AEA Technology. The meeting pertained to performance of concrete materials in nuclear power plant structures, time variation of concrete material properties, methods for evaluating concrete structures, and modeling to predict the effects of degradation factors on concrete materials. As many of the concrete structures in general civil engineering applications as well as nuclear power plant applications inmore » Europe are aging, there is increasing emphasis on assessing the durability of these structures. Information was provided of direct application to the Structural Aging Program which would not have been available without these visits. Of equal, or possibly more importance, was the individual contacts established at the organizations visited. Each organization was extremely interested in both the approach and scope of the Structural Aging Program and requested that they be informed of progress. The initial steps were taken to cooperate with several of these researchers and this should help the Structural Aging Program keep abreast of related European activities. In summary, information obtained during this trip will benefit the ongoing Structural Aging Program by informing Oak Ridge National Laboratory (ORNL) of the extensive European research programs addressing the durability of concrete structures, and also by forming and strengthening acquaintances with counterparts in other countries, thus enhancing the basis for possible international cooperation.« less

  18. SevenOperators, a Mathematica script for harmonic oscillator nuclear matrix elements arising in semileptonic electroweak interactions

    NASA Astrophysics Data System (ADS)

    Haxton, Wick; Lunardini, Cecilia

    2008-09-01

    Semi-leptonic electroweak interactions in nuclei—such as β decay, μ capture, charged- and neutral-current neutrino reactions, and electron scattering—are described by a set of multipole operators carrying definite parity and angular momentum, obtained by projection from the underlying nuclear charge and three-current operators. If these nuclear operators are approximated by their one-body forms and expanded in the nucleon velocity through order |p→|/M, where p→ and M are the nucleon momentum and mass, a set of seven multipole operators is obtained. Nuclear structure calculations are often performed in a basis of Slater determinants formed from harmonic oscillator orbitals, a choice that allows translational invariance to be preserved. Harmonic-oscillator single-particle matrix elements of the multipole operators can be evaluated analytically and expressed in terms of finite polynomials in q, where q is the magnitude of the three-momentum transfer. While results for such matrix elements are available in tabular form, with certain restriction on quantum numbers, the task of determining the analytic form of a response function can still be quite tedious, requiring the folding of the tabulated matrix elements with the nuclear density matrix, and subsequent algebra to evaluate products of operators. Here we provide a Mathematica script for generating these matrix elements, which will allow users to carry out all such calculations by symbolic manipulation. This will eliminate the errors that may accompany hand calculations and speed the calculation of electroweak nuclear cross sections and rates. We illustrate the use of the new script by calculating the cross sections for charged- and neutral-current neutrino scattering in 12C. Program summaryProgram title: SevenOperators Catalogue identifier: AEAY_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEAY_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 2227 No. of bytes in distributed program, including test data, etc.: 19 382 Distribution format: tar.gz Programming language: Mathematica Computer: Any computer running Mathematica; tested on Mac OS X PowerPC (32-bit) running Mathematica 6.0.0 Operating system: Any running Mathematica RAM: Memory requirements determined by Mathematica; 512 MB or greater RAM and hard drive space of at least 3.0 GB recommended Classification: 17.16, 17.19 Nature of problem: Algebraic evaluation of harmonic oscillator nuclear matrix elements for the one-body multipole operators governing semi-leptonic weak interactions, such as charged- or neutral-current neutrino scattering off nuclei. Solution method: Mathematica evaluation of associated angular momentum algebra and spherical Bessel function radial integrals. Running time: Depends on the complexity of the one-body density matrix employed, but times of a few seconds are typical.

  19. The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression

    PubMed Central

    Schneider, Maren; Hellerschmied, Doris; Schubert, Tobias; Amlacher, Stefan; Vinayachandran, Vinesh; Reja, Rohit; Pugh, B. Franklin; Clausen, Tim; Köhler, Alwin

    2015-01-01

    Summary Nuclear pore complexes (NPCs) influence gene expression besides their established function in nuclear transport. The TREX-2 complex localizes to the NPC basket and affects gene-NPC interactions, transcription, and mRNA export. How TREX-2 regulates the gene expression machinery is unknown. Here, we show that TREX-2 interacts with the Mediator complex, an essential regulator of RNA Polymerase (Pol) II. Structural and biochemical studies identify a conserved region on TREX-2, which directly binds the Mediator Med31/Med7N submodule. TREX-2 regulates assembly of Mediator with the Cdk8 kinase and is required for recruitment and site-specific phosphorylation of Pol II. Transcriptome and phenotypic profiling confirm that TREX-2 and Med31 are functionally interdependent at specific genes. TREX-2 additionally uses its Mediator-interacting surface to regulate mRNA export suggesting a mechanism for coupling transcription initiation and early steps of mRNA processing. Our data provide mechanistic insight into how an NPC-associated adaptor complex accesses the core transcription machinery. PMID:26317468

  20. 78 FR 52570 - Draft Emergency Preparedness Frequently Asked Questions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0197] Draft Emergency Preparedness Frequently Asked... comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is making available for comment Emergency Preparedness (EP) frequently asked questions (EPFAQs) No. 2013-004, No. 2013-006, and No. 2013-007. These...

  1. 78 FR 70079 - Appointments to Performance Review Boards for Senior Executive Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0255] Appointments to Performance Review Boards for Senior... for Senior Executive Service. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has announced the... and awarding authorities on performance appraisal ratings and performance awards for Senior Executives...

  2. 76 FR 6085 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ...-2011-0014] RIN 3150-AI49 Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice Availability of Draft Regulatory Guide. SUMMARY: The U.S. Nuclear Regulatory Commission (Commission or NRC) is issuing for public comment Draft Regulatory Guide, DG-5019, ``Reporting and...

  3. 78 FR 38411 - Vogtle Electric Generating Plant, Unit 4; Inspections, Tests, Analyses, and Acceptance Criteria

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... Plant, Unit 4; Inspections, Tests, Analyses, and Acceptance Criteria AGENCY: Nuclear Regulatory Commission. ACTION: Determination of inspections, tests, analyses, and acceptance criteria completion. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) staff has determined that the inspections, tests...

  4. QRAP: A numerical code for projected (Q)uasiparticle (RA)ndom (P)hase approximation

    NASA Astrophysics Data System (ADS)

    Samana, A. R.; Krmpotić, F.; Bertulani, C. A.

    2010-06-01

    A computer code for quasiparticle random phase approximation - QRPA and projected quasiparticle random phase approximation - PQRPA models of nuclear structure is explained in details. The residual interaction is approximated by a simple δ-force. An important application of the code consists in evaluating nuclear matrix elements involved in neutrino-nucleus reactions. As an example, cross sections for 56Fe and 12C are calculated and the code output is explained. The application to other nuclei and the description of other nuclear and weak decay processes are also discussed. Program summaryTitle of program: QRAP ( Quasiparticle RAndom Phase approximation) Computers: The code has been created on a PC, but also runs on UNIX or LINUX machines Operating systems: WINDOWS or UNIX Program language used: Fortran-77 Memory required to execute with typical data: 16 Mbytes of RAM memory and 2 MB of hard disk space No. of lines in distributed program, including test data, etc.: ˜ 8000 No. of bytes in distributed program, including test data, etc.: ˜ 256 kB Distribution format: tar.gz Nature of physical problem: The program calculates neutrino- and antineutrino-nucleus cross sections as a function of the incident neutrino energy, and muon capture rates, using the QRPA or PQRPA as nuclear structure models. Method of solution: The QRPA, or PQRPA, equations are solved in a self-consistent way for even-even nuclei. The nuclear matrix elements for the neutrino-nucleus interaction are treated as the beta inverse reaction of odd-odd nuclei as function of the transfer momentum. Typical running time: ≈ 5 min on a 3 GHz processor for Data set 1.

  5. Building Foundations for Nuclear Security Enterprise Analysis Utilizing Nuclear Weapon Data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Josserand, Terry Michael; Young, Leone; Chamberlin, Edwin Phillip

    The Nuclear Security Enterprise, managed by the National Nuclear Security Administration - a semiautonomous agency within the Department of Energy - has been associated with numerous assessments with respect to the estimating, management capabilities, and practices pertaining to nuclear weapon modernization efforts. This report identifies challenges in estimating and analyzing the Nuclear Security Enterprise through an analysis of analogous timeframe conditions utilizing two types of nuclear weapon data - (1) a measure of effort and (2) a function of time. The analysis of analogous timeframe conditions that utilizes only two types of nuclear weapon data yields four summary observations thatmore » estimators and analysts of the Nuclear Security Enterprise will find useful.« less

  6. Licensed operating reactors: Status summary report data as of December 31, 1991. Volume 16

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1992-03-01

    The Nuclear Regulatory Commission`s annual summary of licensed nuclear power reactor data is based primarily on the report of operating data submitted by licensees for each unit for the month of December because that report contains data for the month of December, the year to date (in this case calendar year 1991) and cumulative data, usually from the date of commercial operation. The data is not independently verified, but various computer checks are made. The report is divided into two sections. The first contains summary highlights and the second contains data on each individual unit in commercial operation. Section 1more » capacity and availability factors are simple arithmetic averages. Section 2 items in the cumulative column are generally as reported by the licensee and notes as to the use of weighted averages and starting dates other than commercial operation are provided.« less

  7. Licensed operating reactors. Status summary report data as of 12-31-94: Volume 19

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-04-01

    The Nuclear Regulatory Commission`s annual summary of licensed nuclear power reactor data is based primarily on the report of operating data submitted by licensees for each unit for the month of December because that report contains data for the month of December, the year to date (in this case calendar year 1994) and cumulative data, usually from the date of commercial operation. The data is not independently verified, but various computer checks are made. The report is divided into two sections. The first contains summary highlights and the second contains data on each individual unit in commercial operation. Section 1more » capacity and availability factors are simple arithmetic averages. Section 2 items in the cumulative column are generally as reported by the licensee and notes as to the use of weighted averages and starting dates other than commercial operation are provided.« less

  8. National briefing summaries: Nuclear fuel cycle and waste management

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schneider, K.J.; Lakey, L.T.; Silviera, D.J.

    The National Briefing Summaries is a compilation of publicly available information concerning the nuclear fuel cycle and radioactive waste management strategies and programs of 21 nations, including the United States and three international agencies that have publicized their activities in this field. It presents available highlight information with references that may be used by the reader for additional information. The information in this document is compiled primarily for use by the US Department of Energy and other US federal agencies and their contractors to provide summary information on radioactive waste management activities in other countries. This document provides an awarenessmore » to managers and technical staff of what is occurring in other countries with regard to strategies, activities, and facilities. The information may be useful in program planning to improve and benefit United States' programs through foreign information exchange. Benefits to foreign exchange may be derived through a number of exchange activities.« less

  9. Burning--Gravitational, Chemical, and Nuclear.

    ERIC Educational Resources Information Center

    Jones, Goronwy Tudor

    1991-01-01

    Energy problems that incorporate power generation in hydroelectric, fossil-fuel burning, and nuclear power stations are presented. The burning process and the energy released are discussed. Practice problems and solutions, a summary of various energy units and conversion factors, and lists of thought-provoking energies and powers are included. (KR)

  10. 78 FR 53484 - Inspections, Tests, Analyses, and Acceptance Criteria; Vogtle Electric Generating Plant, Unit 4

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 052-00026; NRC-2008-0252] Inspections, Tests, Analyses... Commission. ACTION: Determination of inspections, tests, analyses, and acceptance criteria (ITAAC) completion. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) staff has determined that the inspections, tests...

  11. 78 FR 65007 - Inspections, Tests, Analyses, and Acceptance Criteria; Vogtle Electric Generating Plant, Unit 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 052-00026; NRC-2008-0252] Inspections, Tests, Analyses... Commission. ACTION: Determination of inspections, tests, analyses, and acceptance criteria completion. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) staff has determined that the inspections, tests...

  12. 78 FR 53483 - Inspections, Tests, Analyses, and Acceptance Criteria; Vogtle Electric Generating Plant, Unit 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 052-00025; NRC-2008-0252] Inspections, Tests, Analyses... Commission. ACTION: Determination of inspections, tests, analyses, and acceptance criteria (ITAAC) completion. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) staff has determined that the inspections, tests...

  13. 77 FR 48177 - Fuel Oil Systems for Emergency Power Supplies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0159] Fuel Oil Systems for Emergency Power Supplies AGENCY: Nuclear Regulatory Commission. ACTION: Draft regulatory guide; extension of comment period. SUMMARY: On... Regulatory Guide, DG- 1282, ``Fuel Oil Systems for Emergency Power Supplies,'' in the Federal Register for a...

  14. 78 FR 14593 - Advisory Committee on the Medical Uses of Isotopes: Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on the Medical Uses of Isotopes: Meeting Notice AGENCY: U.S. Nuclear Regulatory Commission. ACTION: Notice of Meeting. SUMMARY: NRC will convene a... enforcement policy for Permanent Implant Brachytherapy programs; (3) medical- related events from fiscal year...

  15. State-of-the-art report on piping fracture mechanics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wilkowski, G.M.; Olson, R.J.; Scott, P.M.

    1998-01-01

    This report is an in-depth summary of the state-of-the-art in nuclear piping fracture mechanics. It represents the culmination of 20 years of work done primarily in the US, but also attempts to include important aspects from other international efforts. Although the focus of this work was for the nuclear industry, the technology is also applicable in many cases to fossil plants, petrochemical/refinery plants, and the oil and gas industry. In compiling this detailed summary report, all of the equations and details of the analysis procedure or experimental results are not necessarily included. Rather, the report describes the important aspects andmore » limitations, tells the reader where he can go for further information, and more importantly, describes the accuracy of the models. Nevertheless, the report still contains over 150 equations and over 400 references. The main sections of this report describe: (1) the evolution of piping fracture mechanics history relative to the developments of the nuclear industry, (2) technical developments in stress analyses, material property aspects, and fracture mechanics analyses, (3) unresolved issues and technically evolving areas, and (4) a summary of conclusions of major developments to date.« less

  16. 78 FR 73898 - Operator Licensing Examination Standards for Power Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... Reactors AGENCY: Nuclear Regulatory Commission. ACTION: Draft NUREG; request for comment. SUMMARY: The U.S..., Revision 10, ``Operator Licensing Examination Standards for Power Reactors.'' DATES: Submit comments [email protected] . Both of the Office of New Reactors; or Timothy Kolb, Office of Nuclear Reactor Regulation, U...

  17. 75 FR 66394 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2010-0262] Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory.... 10. Abstract: NRC Form 4 is used to record the summary of a radiation worker's cumulative...

  18. 75 FR 61780 - Advisory Committee on the Medical Uses of Isotopes: Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on the Medical Uses of Isotopes: Meeting Notice AGENCY: U.S. Nuclear Regulatory Commission (NRC). ACTION: Notice of meeting. SUMMARY: NRC will convene a... Conference of Radiation Control Program Directors on a national medical events database; (2) a discussion on...

  19. 77 FR 53769 - Receipts-Based, Small Business Size Standard; Confirmation of Effective Date

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ...-Based, Small Business Size Standard; Confirmation of Effective Date AGENCY: Nuclear Regulatory Commission. ACTION: Direct final rule; confirmation of effective date. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is confirming the effective date of August 22, 2012, for the direct final rule that appeared...

  20. 77 FR 3257 - Transfer of Land Tracts Located at Los Alamos National Laboratory, New Mexico

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... DEPARTMENT OF ENERGY Transfer of Land Tracts Located at Los Alamos National Laboratory, New Mexico AGENCY: National Nuclear Security Administration, U.S. Department of Energy. ACTION: Amended Record of Decision. SUMMARY: The U.S. Department of Energy's National Nuclear Security Administration (DOE/NNSA) is...

  1. 77 FR 55232 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-03; Compliance With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0067] Japan Lessons-Learned Project Directorate Interim...-Learned Project Directorate Interim Staff Guidance; issuance. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the Commission) is issuing the Final Japan Lessons-Learned Project Directorate (JLD...

  2. 77 FR 55231 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-02; Compliance With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0069] Japan Lessons-Learned Project Directorate Interim...-Learned Project Directorate interim staff guidance; issuance. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the Commission) is issuing the Final Japan Lessons-Learned Project Directorate Interim...

  3. 76 FR 70768 - Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and Research, Draft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... NUCLEAR REGULATORY COMMISSION [NRC-2011-0254] Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and Research, Draft Report for Comment; Correction AGENCY: Nuclear Regulatory Commission. ACTION: Draft NUREG; request for comment; correction. SUMMARY: This document corrects a notice appearing...

  4. Overview of Light Hydrogen-Based Low Energy Nuclear Reactions

    NASA Astrophysics Data System (ADS)

    Miley, George H.; Shrestha, Prajakti J.

    This paper reviews light water and hydrogen-based low-energy nuclear reactions (LENRs) including the different methodologies used to study these reactions and the results obtained. Reports of excess heat production, transmutation reactions, and nuclear radiation emission are cited. An aim of this review is to present a summary of the present status of light water LENR research and provide some insight into where this research is heading.

  5. Summary Proceedings of the Congress of International Physicians for the Prevention of Nuclear War (1st, Airlie, Virginia, March 20-25, 1981).

    ERIC Educational Resources Information Center

    International Physicians for the Prevention of Nuclear War, Inc., Boston, MA.

    Physicians charged with the responsibility for the lives of their patients and the health of the community must begin to explore a new province of prevention medicine, the prevention of nuclear war. This conference was held to alert these physicians worldwide, of the mortal peril to public health which could result from nuclear war. The hope is…

  6. Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm.

    PubMed

    Luo, Majing; Zhao, Xueya; Song, Ying; Cheng, Hanhua; Zhou, Rongjia

    2016-11-01

    Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. Studies on autophagic degradation of cytoplasmic components have generated interest in nuclear autophagy. Although its mechanisms and roles have remained elusive, tremendous progress has been made toward understanding nuclear autophagy. Nuclear autophagy is evolutionarily conserved in eukaryotes that may target various nuclear components through a series of processes, including nuclear sensing, nuclear export, autophagic substrate encapsulation and autophagic degradation in the cytoplasm. However, the molecular processes and regulatory mechanisms involved in nuclear autophagy remain largely unknown. Numerous studies have highlighted the importance of nuclear autophagy in physiological and pathological processes such as cancer. This review focuses on current advances in nuclear autophagy and provides a summary of its research history and landmark discoveries to offer new perspectives.

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kennedy, R.P.; Kincaid, R.H.; Short, S.A.

    This report presents the results of part of a two-task study on the engineering characterization of earthquake ground motion for nuclear power plant design. Task I of the study, which is presented in NUREG/CR-3805, Vol. 1, developed a basis for selecting design response spectra taking into account the characteristics of free-field ground motion found to be significant in causing structural damage. Task II incorporates additional considerations of effects of spatial variations of ground motions and soil-structure interaction on foundation motions and structural response. The results of Task II are presented in four parts: (1) effects of ground motion characteristics onmore » structural response of a typical PWR reactor building with localized nonlinearities and soil-structure interaction effects; (2) empirical data on spatial variations of earthquake ground motion; (3) soil-structure interaction effects on structural response; and (4) summary of conclusions and recommendations based on Tasks I and II studies. This report presents the results of the first part of Task II. The results of the other parts will be presented in NUREG/CR-3805, Vols. 3 to 5.« less

  8. Energy materials coordinating committee (EMaCC). Annual technical report, fiscal year 2005

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    2006-09-29

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. Topical subcommittees of the EMaCC are responsible for conducting seminars and otherwise facilitating information flow between DOE organizational units in materials areas of particular importance to the Department. The EMaCCmore » Terms of Reference were recently modified and developed into a Charter that was approved on June 5, 2003. As a result of this reorganization, the existing subcommittees were disbanded and new subcommittees are being formed. The FY 2004 budget summary for DOE Materials Activities is presented on page 8. The distribution of these funds between DOE laboratories, private industry, academia and other organizations is presented in tabular form on page 10. Following the budget summary is a set of detailed program descriptions for the FY 2004 DOE Materials activities. These descriptions are presented according to the organizational structure of the Department. A mission statement, a budget summary listing the project titles and FY 2004 funding, and detailed project summaries are presented for each Assistant Secretary office, the Office of Science, and the National Nuclear Security Administration. The project summaries also provide DOE, laboratory, academic and industrial contacts for each project, as appropriate.« less

  9. Energy materials coordinating committee (EMaCC). Annual technical report, fiscal year 2004

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    none,

    2005-08-31

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. Topical subcommittees of the EMaCC are responsible for conducting seminars and otherwise facilitating information flow between DOE organizational units in materials areas of particular importance to the Department. The EMaCCmore » Terms of Reference were recently modified and developed into a Charter that was approved on June 5, 2003. As a result of this reorganization, the existing subcommittees were disbanded and new subcommittees are being formed. The FY 2004 budget summary for DOE Materials Activities is presented on page 8. The distribution of these funds between DOE laboratories, private industry, academia and other organizations is presented in tabular form on page 10. Following the budget summary is a set of detailed program descriptions for the FY 2004 DOE Materials activities. These descriptions are presented according to the organizational structure of the Department. A mission statement, a budget summary listing the project titles and FY 2004 funding, and detailed project summaries are presented for each Assistant Secretary office, the Office of Science, and the National Nuclear Security Administration. The project summaries also provide DOE, laboratory, academic and industrial contacts for each project, as appropriate.« less

  10. DHS National Technical Nuclear Forensics Program FY 10 Summary Report: Graduate Mentoring Assistance Program (GMAP)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martha R. Finck Ph.D.

    2011-10-01

    This program provides practical training to DHS graduate fellows in the DOE laboratory complex. It involves coordinating students, their thesis advisors, and their laboratory project mentors in establishing a meaningful program of research which contributes to the graduate student's formation as a member of the nuclear forensics community. The summary report details the student/mentor experience and future plans after the first summer practicum. This program provides practical training to DHS graduate fellows in the DOE laboratory complex. It involves coordinating students, their thesis advisors, and their laboratory project mentors in establishing a meaningful program of research which contributes to themore » graduate student's formation as a member of the nuclear forensics community. This final written report includes information concerning the overall mentoring experience, including benefits (to the lab, the mentors, and the students), challenges, student research contributions, and lab mentor interactions with students home universities. Idaho National Laboratory hosted two DHS Nuclear Forensics graduate Fellows (nuclear engineering) in summer 2011. Two more Fellows (radiochemistry) are expected to conduct research at the INL under this program starting in 2012. An undergraduate Fellow (nuclear engineering) who worked in summer 2011 at the laboratory is keenly interested in applying for the NF Graduate Fellowship this winter with the aim of returning to INL. In summary, this program appears to have great potential for success in supporting graduate level students who pursue careers in nuclear forensics. This relatively specialized field may not have been an obvious choice for some who have already shown talent in the traditional areas of chemistry or nuclear engineering. The active recruiting for this scholarship program for candidates at universities across the U.S. brings needed visibility to this field. Not only does this program offer critical practical training to these students, it brings attention to a very attractive field of work where young professionals are urgently required in order for the future. The effectiveness of retaining such talent remains to be seen and may be primarily controlled by the availability of DOE laboratory research funding in this field in the years to come.« less

  11. Summary of SMIRT20 Preconference Topical Workshop – Identifying Structural Issues in Advanced Reactors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    William Richins; Stephen Novascone; Cheryl O'Brien

    Summary of SMIRT20 Preconference Topical Workshop – Identifying Structural Issues in Advanced Reactors William Richins1, Stephen Novascone1, and Cheryl O’Brien1 1Idaho National Laboratory, US Dept. of Energy, Idaho Falls, Idaho, USA, e-mail: William.Richins@inl.gov The Idaho National Laboratory (INL, USA) and IASMiRT sponsored an international forum Nov 5-6, 2008 in Porvoo, Finland for nuclear industry, academic, and regulatory representatives to identify structural issues in current and future advanced reactor design, especially for extreme conditions and external threats. The purpose of this Topical Workshop was to articulate research, engineering, and regulatory Code development needs. The topics addressed by the Workshop were selectedmore » to address critical industry needs specific to advanced reactor structures that have long lead times and can be the subject of future SMiRT technical sessions. The topics were; 1) structural/materials needs for extreme conditions and external threats in contemporary (Gen. III) and future (Gen. IV and NGNP) advanced reactors and 2) calibrating simulation software and methods that address topic 1 The workshop discussions and research needs identified are presented. The Workshop successfully produced interactive discussion on the two topics resulting in a list of research and technology needs. It is recommended that IASMiRT communicate the results of the discussion to industry and researchers to encourage new ideas and projects. In addition, opportunities exist to retrieve research reports and information that currently exists, and encourage more international cooperation and collaboration. It is recommended that IASMiRT continue with an off-year workshop series on select topics.« less

  12. Health Physics Positions Data Base: Revision 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kerr, G.D.; Borges, T.; Stafford, R.S.

    1994-02-01

    The Health Physics Positions (HPPOS) Data Base of the Nuclear Regulatory Commission (NRC) is a collection of NRC staff positions on a wide range of topics involving radiation protection (health physics). It consists of 328 documents in the form of letters, memoranda, and excerpts from technical reports. The HPPOS Data Base was developed by the NRC Headquarters and Regional Offices to help ensure uniformity in inspections, enforcement, and licensing actions. Staff members of the Oak Ridge National Laboratory (ORNL) have assisted the NRC staff in summarizing the documents during the preparation of this NUREG report. These summaries are also beingmore » made available as a {open_quotes}stand alone{close_quotes} software package for IBM and IBM-compatible personal computers. The software package for this report is called HPPOS Version 2.0. A variety of indexing schemes were used to increase the usefulness of the NUREG report and its associated software. The software package and the summaries in the report are written in the context of the {open_quotes}new{close_quotes} 10 CFR Part 20 ({section}{section}20.1001--20.2401). The purpose of this NUREG report is to allow interested individuals to familiarize themselves with the contents of the HPPOS Data Base and with the basis of many NRC decisions and regulations. The HPPOS summaries and original documents are intended to serve as a source of information for radiation protection programs at nuclear research and power reactors, nuclear medicine, and other industries that either process or use nuclear materials.« less

  13. Meteorological annual report for 1995 at the Savannah River Site

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hunter, C.H.; Tatum, C.P.

    1996-12-01

    The Environmental Technology Section (ETS) of the Savannah River Technology Center (SRTC) collects, archives, and analyzes basic meteorological data supporting a variety of activities at SRS. These activities include the design, construction, and operation of nuclear and non-nuclear facilities, emergency response, environmental compliance, resource management, and environmental research. This report contains tabular and graphical summaries of data collected during 1995 for temperature, precipitation, relative humidity, wind, barometric pressure, and solar radiation. Most of these data were collected at the central Climatology Facility. Summaries of temperature and relative humidity were generated with data from the lowest level of measurement at themore » Central Climatology Site tower (13 feet above ground). (Relative humidity is calculated from measurements of dew-point temperature.) Wind speed summaries were generated with data from the second measurement level (58 feet above ground). Wind speed measurements from this level are believed to best represent open, well-exposed areas of the Site. Precipitation summaries were based on data from the Building 773-A site since quality control algorithms for the central Climatology Facility rain gauge data were not finalized at the time this report was prepared. This report also contains seasonal and annual summaries of joint occurrence frequencies for selected wind speed categories by 22.5 degree wind direction sector (i.e., wind roses). Wind rose summaries are provided for the 200-foot level of the Central Climatology tower and for each of the eight 200-foot area towers.« less

  14. Evaluation of Nuclear Facility Decommissioning Projects program: a reference test reactor. Project summary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boing, L.E.; Miller, R.L.

    1983-10-01

    This document presents, in summary form, generic conceptual information relevant to the decommissioning of a reference test reactor (RTR). All of the data presented were extracted from NUREG/CR-1756 and arranged in a form that will provide a basis for future comparison studies for the Evaluation of Nuclear Facility Decommissioning Projects (ENFDP) program. During the data extraction process no attempt was made to challenge any of the assumptions used in the original studies nor was any attempt made to update assumed methods or processes to state-of-the-art decommissioning techniques. In a few instances obvious errors were corrected after consultation with the studymore » author.« less

  15. 78 FR 41835 - Inflation Adjustments to the Price-Anderson Act Financial Protection Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ...;Prices of new books are listed in the first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0... Price-Anderson Act Financial Protection Regulations AGENCY: Nuclear Regulatory Commission. ACTION: Final rule. SUMMARY: The Atomic Energy Act of 1954, as amended (AEA), requires the U.S. Nuclear Regulatory...

  16. 75 FR 9452 - Solicitation of Topics for Discussion at a Spent Fuel Storage and Transportation Licensing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0076] Solicitation of Topics for Discussion at a Spent...: Solicitation of Topics for Discussion at a Spent Fuel Storage and Transportation Licensing Conference. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is soliciting input on topics for discussion at a...

  17. 76 FR 42159 - Lifting of Sanctions on Person Associated With the A.Q. Khan Nuclear Procurement Network

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... DEPARTMENT OF STATE [Public Notice: 7525] Lifting of Sanctions on Person Associated With the A.Q. Khan Nuclear Procurement Network AGENCY: Bureau of International Security and Nonproliferation, Department of State. ACTION: Notice. SUMMARY: A determination has been made to lift the measures imposed on...

  18. 77 FR 13155 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ...: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of the OMB review of information collection and solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review the...

  19. 78 FR 70353 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ...: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory Commission. ACTION: Notice of the OMB review of information collection and solicitation of public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review the...

  20. 10 CFR 26.203 - General provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false General provisions. 26.203 Section 26.203 Energy NUCLEAR... his or her duties for any part of a working tour as a result of fatigue. The procedure must— (i....717: (1) A summary for each nuclear power plant site of all instances during the previous calendar...

  1. 10 CFR 26.211 - Fatigue assessments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Fatigue assessments. 26.211 Section 26.211 Energy NUCLEAR... competently perform his or her duties for any part of a working tour because of fatigue, except if, following... summary for each nuclear power plant site of instances of fatigue assessments that were conducted during...

  2. 10 CFR 26.203 - General provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false General provisions. 26.203 Section 26.203 Energy NUCLEAR... his or her duties for any part of a working tour as a result of fatigue. The procedure must— (i....717: (1) A summary for each nuclear power plant site of all instances during the previous calendar...

  3. 10 CFR 26.211 - Fatigue assessments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Fatigue assessments. 26.211 Section 26.211 Energy NUCLEAR... competently perform his or her duties for any part of a working tour because of fatigue, except if, following... summary for each nuclear power plant site of instances of fatigue assessments that were conducted during...

  4. 10 CFR 26.211 - Fatigue assessments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Fatigue assessments. 26.211 Section 26.211 Energy NUCLEAR... competently perform his or her duties for any part of a working tour because of fatigue, except if, following... summary for each nuclear power plant site of instances of fatigue assessments that were conducted during...

  5. 10 CFR 26.203 - General provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false General provisions. 26.203 Section 26.203 Energy NUCLEAR... his or her duties for any part of a working tour as a result of fatigue. The procedure must— (i....717: (1) A summary for each nuclear power plant site of all instances during the previous calendar...

  6. 75 FR 64359 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-19

    ... environmental impact statement or environmental assessment need be prepared for these amendments. If the... authorization to upgrade selected Emergency Action Levels based on Nuclear Energy Institute (NEI) 99-01... of NRC Regulatory Issue Summary 2003-18, Supplement 2, ``Use of Nuclear Energy Institute (NEI) 99-01...

  7. Nuclear Power and the Environment.

    ERIC Educational Resources Information Center

    International Atomic Energy Agency, Vienna (Austria).

    This booklet is a summary of an international symposium, held in August 1970 in New York City, on the environmental aspects of nuclear power stations. The symposium was convened under the sponsorship of the International Atomic Energy Agency (IAEA) and the U.S. Atomic Energy Commission (USAEC). The information is presented in a condensed and…

  8. Far-field environment working group summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pearcy, E.C.

    1995-09-01

    This article is a summary of the proceedings of a group discussion which took place at the Workshop on the Role of Natural Analogs in Geologic Disposal of High-Level Nuclear Waste in San Antonio, Texas on July 22-25, 1991. The working group concentrated on the subject of the potential impacts of underground disposal of high-level radioactive wastes on the far-field environment.

  9. MOOSE: A parallel computational framework for coupled systems of nonlinear equations.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Derek Gaston; Chris Newman; Glen Hansen

    Systems of coupled, nonlinear partial differential equations (PDEs) often arise in simulation of nuclear processes. MOOSE: Multiphysics Object Oriented Simulation Environment, a parallel computational framework targeted at the solution of such systems, is presented. As opposed to traditional data-flow oriented computational frameworks, MOOSE is instead founded on the mathematical principle of Jacobian-free Newton-Krylov (JFNK) solution methods. Utilizing the mathematical structure present in JFNK, physics expressions are modularized into `Kernels,'' allowing for rapid production of new simulation tools. In addition, systems are solved implicitly and fully coupled, employing physics based preconditioning, which provides great flexibility even with large variance in timemore » scales. A summary of the mathematics, an overview of the structure of MOOSE, and several representative solutions from applications built on the framework are presented.« less

  10. Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines

    PubMed Central

    Hearst, Scoty M.; Gilder, Andrew S.; Negi, Sandeep S.; Davis, Misty D.; George, Eric M.; Whittom, Angela A.; Toyota, Cory G.; Husedzinovic, Alma; Gruss, Oliver J.; Hebert, Michael D.

    2009-01-01

    Summary Cajal bodies (CBs) are nuclear structures that are thought to have diverse functions, including small nuclear ribonucleoprotein (snRNP) biogenesis. The phosphorylation status of coilin, the CB marker protein, might impact CB formation. We hypothesize that primary cells, which lack CBs, contain different phosphoisoforms of coilin compared with that found in transformed cells, which have CBs. Localization, self-association and fluorescence recovery after photobleaching (FRAP) studies on coilin phosphomutants all suggest this modification impacts the function of coilin and may thus contribute towards CB formation. Two-dimensional gel electrophoresis demonstrates that coilin is hyperphosphorylated in primary cells compared with transformed cells. mRNA levels of the nuclear phosphatase PPM1G are significantly reduced in primary cells and expression of PPM1G in primary cells induces CBs. Additionally, PPM1G can dephosphorylate coilin in vitro. Surprisingly, however, expression of green fluorescent protein alone is sufficient to form CBs in primary cells. Taken together, our data support a model whereby coilin is the target of an uncharacterized signal transduction cascade that responds to the increased transcription and snRNP demands found in transformed cells. PMID:19435804

  11. Personnel Requirements, Education, and Training for Civilian Nuclear Activities, 1984-2000. Executive Summary.

    ERIC Educational Resources Information Center

    Stevenson, Wayne

    This report provides projections of the employment of scientists, engineers, technicians, and other occupations for the civilian nuclear industry through the year 2000. Low, medium, and high projections are provided. In all cases, a substantial number of job openings are anticipated to fill needs created by employment growth, retirement, death,…

  12. BOILING NUCLEAR SUPERHEATER (BONUS) POWER STATION. Final Summary Design Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1962-05-01

    The design and construction of the Boiling Nuclear Superheater (BONUS) Power Station at Punta Higuera on the seacoast at the westernmost tip of Puerto Rico are described. The reactor has an output of 17.5 Mw(e). This report will serve as a source of information for personnel engaged in management, evaluation, and training. (N.W.R.)

  13. Nuclear Accident Crisis and Liver Disease: A Summary on Evidences

    PubMed Central

    Wiwanitkit, Viroj

    2013-01-01

    The present global concern is on the adverse effect due to exposure to nuclides expelled from the disrupted nuclear power plant accident in Japan. The exposure can induce several adverse effects. In this specific brief review, the author summarizes the evidences on the effect on liver. Discussion is focused on several liver diseases. PMID:25125994

  14. Risk Informed Assessment of Regulatory and Design Requirements for Future Nuclear Power Plants - Final Technical Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ritterbusch, Stanley; Golay, Michael; Duran, Felicia

    2003-01-29

    OAK B188 Summary of methods proposed for risk informing the design and regulation of future nuclear power plants. All elements of the historical design and regulation process are preserved, but the methods proposed for new plants use probabilistic risk assessment methods as the primary decision making tool.

  15. Seismic assessment of Technical Area V (TA-V).

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Medrano, Carlos S.

    The Technical Area V (TA-V) Seismic Assessment Report was commissioned as part of Sandia National Laboratories (SNL) Self Assessment Requirement per DOE O 414.1, Quality Assurance, for seismic impact on existing facilities at Technical Area-V (TA-V). SNL TA-V facilities are located on an existing Uniform Building Code (UBC) Seismic Zone IIB Site within the physical boundary of the Kirtland Air Force Base (KAFB). The document delineates a summary of the existing facilities with their safety-significant structure, system and components, identifies DOE Guidance, conceptual framework, past assessments and the present Geological and Seismic conditions. Building upon the past information and themore » evolution of the new seismic design criteria, the document discusses the potential impact of the new standards and provides recommendations based upon the current International Building Code (IBC) per DOE O 420.1B, Facility Safety and DOE G 420.1-2, Guide for the Mitigation of Natural Phenomena Hazards for DOE Nuclear Facilities and Non-Nuclear Facilities.« less

  16. An overview of research activities on materials for nuclear applications at the INL Safety, Tritium and Applied Research facility

    NASA Astrophysics Data System (ADS)

    Calderoni, P.; Sharpe, J.; Shimada, M.; Denny, B.; Pawelko, B.; Schuetz, S.; Longhurst, G.; Hatano, Y.; Hara, M.; Oya, Y.; Otsuka, T.; Katayama, K.; Konishi, S.; Noborio, K.; Yamamoto, Y.

    2011-10-01

    The Safety, Tritium and Applied Research facility at the Idaho National Laboratory is a US Department of Energy National User Facility engaged in various aspects of materials research for nuclear applications related to fusion and advanced fission systems. Research activities are mainly focused on the interaction of tritium with materials, in particular plasma facing components, liquid breeders, high temperature coolants, fuel cladding, cooling and blanket structures and heat exchangers. Other activities include validation and verification experiments in support of the Fusion Safety Program, such as beryllium dust reactivity and dust transport in vacuum vessels, and support of Advanced Test Reactor irradiation experiments. This paper presents an overview of the programs engaged in the activities, which include the US-Japan TITAN collaboration, the US ITER program, the Next Generation Power Plant program and the tritium production program, and a presentation of ongoing experiments as well as a summary of recent results with emphasis on fusion relevant materials.

  17. Current research in nuclear medicine and molecular imaging in Italy: highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging.

    PubMed

    Cuocolo, A

    2011-06-01

    The 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (AIMN) took place in Rimini on March 18-21, 2011 under the chairmanship of Professor Stefano Fanti. The program was of excellent quality and put a further step for the settlement of the standardized AIMN congress structure. A large industrial exhibition demonstrated the latest technological innovations and developments within the field. The congress was a great success with more than 1100 total participants and more than 360 abstracts received. Of these, 40 abstracts were accepted for oral and 285 for poster presentations. The original investigations presented were related to different areas of nuclear medicine and molecular imaging, with particular focus on advances in instrumentation and data processing, progress in radiochemistry and pharmacy, novel diagnostics and therapeutics, and new insights in well established areas of clinical application, such as oncology, cardiology, neurology, psychiatry, endocrinology, paediatrics, and infection and inflammation. Noteworthy, several presentations at this congress, focusing on quantitative interpretation of the imaging data and on pragmatic endpoints, such as adverse outcomes, identified when nuclear medicine procedures achieved clinical effectiveness for patient care and patient management and further demonstrated that nuclear medicine plays a crucial role in the contemporary medical scenario. This highlights lecture is only a brief summary of the large amount of data presented and discussed, which can be found in much greater detail in the congress abstract book, published as volume 55, supplement 1 of the Q J Nucl Med Mol Imaging in April 2011.

  18. Nuclear quantum many-body dynamics. From collective vibrations to heavy-ion collisions

    NASA Astrophysics Data System (ADS)

    Simenel, Cédric

    2012-11-01

    A summary of recent researches on nuclear dynamics with realistic microscopic quantum approaches is presented. The Balian-Vénéroni variational principle is used to derive the time-dependent Hartree-Fock (TDHF) equation describing the dynamics at the mean-field level, as well as an extension including small-amplitude quantum fluctuations which is equivalent to the time-dependent random-phase approximation (TDRPA). Such formalisms as well as their practical implementation in the nuclear physics framework with modern three-dimensional codes are discussed. Recent applications to nuclear dynamics, from collective vibrations to heavy-ion collisions are presented. Particular attention is devoted to the interplay between collective motions and internal degrees of freedom. For instance, the harmonic nature of collective vibrations is questioned. Nuclei are also known to exhibit superfluidity due to pairing residual interaction. Extensions of the theoretical approach to study such pairing vibrations are now available. Large amplitude collective motions are investigated in the framework of heavy-ion collisions leading, for instance, to the formation of a compound system. How fusion is affected by the internal structure of the collision partners, such as their deformation, is discussed. Other mechanisms in competition with fusion, and responsible for the formation of fragments which differ from the entrance channel (transfer reactions, deep-inelastic collisions, and quasi-fission) are investigated. Finally, studies of actinide collisions forming, during very short times of few zeptoseconds, the heaviest nuclear systems available on Earth, are presented.

  19. Progress on DCLL Blanket Concept

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wong, Clement; Abdou, M.; Katoh, Yutai

    2013-09-01

    Under the US Fusion Nuclear Science and Technology Development program, we have selected the Dual Coolant Lead Lithium concept (DCLL) as a reference blanket, which has the potential to be a high performance DEMO blanket design with a projected thermal efficiency of >40%. Reduced activation ferritic/martensitic (RAF/M) steel is used as the structural material. The self-cooled breeder PbLi is circulated for power conversion and for tritium breeding. A SiC-based flow channel insert (FCI) is used as a means for magnetohydrodynamic pressure drop reduction from the circulating liquid PbLi and as a thermal insulator to separate the high-temperature PbLi (~700°C) frommore » the helium-cooled RAF/M steel structure. We are making progress on related R&D needs to address critical Fusion Nuclear Science and Facility (FNSF) and DEMO blanket development issues. When performing the function as the Interface Coordinator for the DCLL blanket concept, we had been developing the mechanical design and performing neutronics, structural and thermal hydraulics analyses of the DCLL TBM module. We had estimated the necessary ancillary equipment that will be needed at the ITER site and a detailed safety impact report has been prepared. This provided additional understanding of the DCLL blanket concept in preparation for the FNSF and DEMO. This paper will be a summary report on the progress of the DCLL TBM design and R&Ds for the DCLL blanket concept.« less

  20. Pellet bed reactor for nuclear propelled vehicles: Part 2: Missions and vehicle integration trades

    NASA Technical Reports Server (NTRS)

    Haloulakos, V. E.

    1991-01-01

    Mission and vehicle integration tradeoffs involving the use of the pellet bed reactor (PBR) for nuclear powered vehicles is discussed, with much of the information being given in viewgraph form. Information is given on propellant tank geometries, shield weight requirements for conventional tank configurations, effective specific impulse, radiation mapping, radiation dose rate after shutdown, space transfer vehicle design data, a Mars mission summary, sample pellet bed nuclear orbit transfer vehicle mass breakdown, and payload fraction vs. velocity increment.

  1. RNA Seeds Higher Order Assembly of FUS Protein

    PubMed Central

    Schwartz, Jacob C.; Wang, Xueyin; Podell, Elaine R.; Cech, Thomas R.

    2014-01-01

    SUMMARY The abundant nuclear RNA-binding protein FUS binds the CTD of RNA polymerase II in an RNA-dependent manner, affecting Ser2 phosphorylation and transcription. Here we examine the mechanism of this process and find that RNA binding nucleates the formation of higher order FUS RNP assemblies that bind the CTD. Both the low-complexity domain and the RGG domain of FUS contribute to assembly. The assemblies appear fibrous by electron microscopy and have characteristics of beta-zipper structures. These results support the emerging view that the pathologic protein aggregation seen in neurodegenerative diseases such as ALS may occur by exaggeration of functionally important assemblies of RNA-binding proteins. PMID:24268778

  2. Workshop on the role of natural analogs in geologic disposal of high-level nuclear waste: Proceedings

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kovach, L.A.; Murphy, W.M.

    1995-09-01

    A Workshop on the Role of Natural Analogs in Geologic Disposal of High-Level Nuclear Waste was held in San Antonio, Texas on July 22--25, 1991. The proceedings comprise seventeen papers submitted by participants at the workshop. A series of papers addresses the relation of natural analog studies to the regulation, performance assessment, and licensing of a geologic repository. Applications of reasoning by analogy are illustrated in papers on the role of natural analogs in studies of earthquakes, petroleum, and mineral exploration. A summary is provided of a recently completed, internationally coordinated natural analog study at Pocos de Caldas, Brazil. Papersmore » also cover problems and applications of natural analog studies in four technical areas of nuclear waste management-. waste form and waste package, near-field processes and environment, far-field processes and environment, and volcanism and tectonics. Summaries of working group deliberations in these four technical areas provide reviews and proposals for natural analog applications. Individual papers have been cataloged separately.« less

  3. Analysis of nuclear waste disposal in space, phase 3. Volume 1: Executive summary of technical report

    NASA Technical Reports Server (NTRS)

    Rice, E. E.; Miller, N. E.; Yates, K. R.; Martin, W. E.; Friedlander, A. L.

    1980-01-01

    The objectives, approach, assumptions, and limitations of a study of nuclear waste disposal in space are discussed with emphasis on the following: (1) payload characterization; (2) safety assessment; (3) health effects assessment; (4) long-term risk assessment; and (5) program planning support to NASA and DOE. Conclusions are presented for each task.

  4. Bidirectional synaptic structural plasticity after chronic cocaine administration occurs through Rap1 small GTPase signaling

    PubMed Central

    Cahill, Michael E.; Bagot, Rosemary C.; Gancarz, Amy M.; Walker, Deena M.; Sun, HaoSheng; Wang, Zi-Jun; Heller, Elizabeth A.; Feng, Jian; Kennedy, Pamela J.; Koo, Ja Wook; Cates, Hannah M.; Neve, Rachael L.; Shen, Li; Dietz, David M.

    2016-01-01

    Summary Dendritic spines are the sites of most excitatory synapses in the CNS, and opposing alterations in the synaptic structure of medium spiny neurons (MSNs) of the nucleus accumbens, a primary brain reward region, are seen at early vs. late time points after cocaine administration. Here we investigate the time-dependent molecular and biochemical processes that regulate this bidirectional synaptic structural plasticity of NAc MSNs and associated changes in cocaine reward in response to chronic cocaine exposure. Our findings reveal key roles for the bidirectional synaptic expression of the Rap1b small GTPase and an associated local-synaptic protein translation network in this process. The transcriptional mechanisms and pathway-specific inputs to NAc that regulate Rap1b expression are also characterized. Collectively, these findings provide a precise mechanism by which nuclear to synaptic interactions induce “metaplasticity” in NAc MSNs, and we reveal the specific effects of this plasticity on reward behavior in a brain circuit-specific manner. PMID:26844834

  5. Structure and Biological Function of the RNA Pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus

    PubMed Central

    Messing, Simon A.J.; Gabelli, Sandra B.; Liu, Quansheng; Celesnik, Helena; Belasco, Joel G.; Piñeiro, Silvia A.; Amzel, L. Mario

    2009-01-01

    SUMMARY Until recently, the mechanism of mRNA decay in bacteria was thought to be different from that of eukaryotes. This paradigm changed with the discovery that RppH (ORF176/NudH/YgdP), an Escherichia coli enzyme that belongs to the Nudix superfamily, is an RNA resolution pyrophosphohydrolase that initiates mRNA decay by cleaving pyrophosphate from the 5′-triphosphate. Here we report the 1.9 Å structure of the Nudix hydrolase BdRppH from Bdellovibrio bacteriovorus, a bacterium that feeds on other Gram-negative bacteria. Based on the structure of the enzyme alone and in complex with GTP-Mg2+, we propose a mode of RNA binding similar to that of the nuclear decapping enzyme from Xenopus laevis, X29. In additional experiments, we show that BdRppH can indeed function in vitro and in vivo as an RNA pyrophosphohydrolase. These findings set the basis for the identification of possible decapping enzymes in other bacteria. PMID:19278661

  6. Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA

    PubMed Central

    Yunus, Ali A.; Lima, Christopher D.

    2009-01-01

    Summary Siz1 is a founding member of the Siz/PIAS RING family of SUMO E3 ligases. The x-ray structure of an active Siz1 ligase revealed an elongated tripartite architecture comprised of an N-terminal PINIT domain, a central zinc-containing RING-like SP-RING domain, and a C-terminal domain we term the SP-CTD. Structure-based mutational analysis and biochemical studies show that the SP-RING and SP-CTD are required for activation of the E2~SUMO thioester while the PINIT domain is essential for redirecting SUMO conjugation to the proliferating cell nuclear antigen (PCNA) at lysine 164, a non-consensus lysine residue that is not modified by the SUMO E2 in the absence of Siz1. Mutational analysis of Siz1 and PCNA revealed surfaces on both proteins that are required for efficient SUMO modification of PCNA in vitro and in vivo. PMID:19748360

  7. NMR Spectroscopy in Glass Science: A Review of the Elements

    PubMed Central

    2018-01-01

    The study of inorganic glass structure is critically important for basic glass science and especially the commercial development of glasses for a variety of technological uses. One of the best means by which to achieve this understanding is through application of solid-state nuclear magnetic resonance (NMR) spectroscopy, which has a long and interesting history. This technique is element specific, but highly complex, and thus, one of the many inquiries made by non-NMR specialists working in glass science is what type of information and which elements can be studied by this method. This review presents a summary of the different elements that are amenable to the study of glasses by NMR spectroscopy and provides examples of the type of atomic level structural information that can be achieved. It serves to inform the non-specialist working in glass science and technology about some of the benefits and challenges involved in the study of inorganic glass structure using modern, readily-available NMR methods. PMID:29565328

  8. Radionuclide metrology research for nuclear site decommissioning

    NASA Astrophysics Data System (ADS)

    Judge, S. M.; Regan, P. H.

    2017-11-01

    The safe and cost-effective decommissioning of legacy nuclear sites relies on accurate measurement of the radioactivity content of the waste materials, so that the waste can be assigned to the most appropriate disposal route. Such measurements are a new challenge for the science of radionuclide metrology which was established largely to support routine measurements on operating nuclear sites and other applications such as nuclear medicine. In this paper, we provide a brief summary of the international measurement system that is established to enable nuclear site operators to demonstrate that measurements are accurate, independent and fit for purpose, and highlight some of the projects that are underway to adapt the measurement system to meet the changing demands from the industry.

  9. Risk in nuclear power plants due to natural hazard phenomena

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lu, S.C.

    1995-12-01

    For the safety of nuclear power plants, it is important to identify potential areas of vulnerabilities to internal as well as external events to which nuclear power plants are exposed. This paper summarizes the risk in nuclear power plants due to natural hazard phenomena such as earthquakes, winds and tornadoes, floods, etc. The reported results are based on a limited number of probabilistic risk assessments (PRAS) performed for a few of the operating nuclear power plants within the United States. The summary includes an importance ranking of various natural hazard phenomena based on their contribution to the plant risk alongmore » with insights observed from the PRA studies.« less

  10. Possible Nuclear Safeguards Applications: Workshop on Next-Generation Laser Compton Gamma Source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Durham, J. Matthew

    2016-11-17

    These are a set of slides for the development of a next-generation photon source white paper. The following topics are covered in these slides: Nuclear Safeguards; The Nuclear Fuel Cycle; Precise isotopic determination via NRF; UF 6 Enrichment Assay; and Non-Destructive Assay of Spent Nuclear Fuel. In summary: A way to non-destructively measure precise isotopics of ~kg and larger samples has multiple uses in nuclear safeguards; Ideally this is a compact, fieldable device that can be used by international inspectors. Must be rugged and reliable; A next-generation source can be used as a testing ground for these techniques as technologymore » develops.« less

  11. 16th International Conference on Nuclear Structure: NS2016

    DOE PAGES

    Galindo-Uribarri, Alfredo

    2016-10-28

    Every two years the Nuclear Structure (NS) conference series brings together researchers from an international community of experimental and theoretical nuclear physicists to present and discuss their latest results in nuclear structure. This biennial conference covered the latest results on experimental and theoretical research into the structure of nuclei at the extremes of isospin, excitation energy, mass, and angular momentum. Topics included many of the most exciting areas of modern nuclear structure research such as transitional behavior, nuclear structure and its evolution across the nuclear landscape, shell structure, collectivity, nuclear structure with radioactive beams, and macroscopic and microscopic approaches tomore » nuclear structure.« less

  12. 16th International Conference on Nuclear Structure: NS2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Galindo-Uribarri, Alfredo

    Every two years the Nuclear Structure (NS) conference series brings together researchers from an international community of experimental and theoretical nuclear physicists to present and discuss their latest results in nuclear structure. This biennial conference covered the latest results on experimental and theoretical research into the structure of nuclei at the extremes of isospin, excitation energy, mass, and angular momentum. Topics included many of the most exciting areas of modern nuclear structure research such as transitional behavior, nuclear structure and its evolution across the nuclear landscape, shell structure, collectivity, nuclear structure with radioactive beams, and macroscopic and microscopic approaches tomore » nuclear structure.« less

  13. The Human Protein PRR14 Tethers Heterochromatin to the Nuclear Lamina During Interphase and Mitotic Exit

    PubMed Central

    Poleshko, Andrey; Mansfield, Katelyn M.; Burlingame, Caroline C.; Andrake, Mark D.; Shah, Neil R.; Katz, Richard A.

    2013-01-01

    SUMMARY The nuclear lamina is a protein meshwork that lies under the inner nuclear membrane of metazoan cells. One function of the nuclear lamina is to organize heterochromatin at the inner nuclear periphery. However, very little is known about how heterochromatin attaches to the nuclear lamina and how such attachments are restored at mitotic exit. Here we show that a previously unstudied human protein, PRR14, functions to tether heterochromatin to the nuclear periphery during interphase, through associations with heterochromatin protein 1 (HP1) and the nuclear lamina. During early mitosis, PRR14 is released from the nuclear lamina and chromatin, and remains soluble. Strikingly, at the onset of anaphase, PRR14 is incorporated rapidly into chromatin through HP1 binding. Finally, in telophase, PRR14 relocalizes to the reforming nuclear lamina. This stepwise reassembly of PRR14 suggests a novel function in the selection of HP1–bound heterochromatin for reattachment to the nuclear lamina as cells exit mitosis. PMID:24209742

  14. Nuclear condensation during mouse erythropoiesis requires caspase-3-mediated nuclear opening

    PubMed Central

    Zhao, Baobing; Mei, Yang; Schipma, Matthew J; Roth, Eric Wayne; Bleher, Reiner; Rappoport, Joshua Z.; Wickrema, Amittha; Yang, Jing; Ji, Peng

    2016-01-01

    SUMMARY Mammalian erythropoiesis involves chromatin condensation that is initiated in the early stage of terminal differentiation. The mechanisms of chromatin condensation during erythropoiesis are unclear. Here, we show that the mouse erythroblast forms large, transient, and recurrent nuclear openings that coincide with the condensation process. The opening lacks nuclear lamina, nuclear pore complexes, and nuclear membrane, but it is distinct from nuclear envelope changes that occur during apoptosis and mitosis. A fraction of the major histones are released from the nuclear opening and degraded in the cytoplasm. We demonstrate that caspase-3 is required for the nuclear opening formation throughout terminal erythropoiesis. Loss of caspase-3 or ectopic expression of a caspase-3 non-cleavable lamin B mutant blocks nuclear opening formation, histone release, chromatin condensation, and terminal erythroid differentiation. We conclude that caspase-3-mediated nuclear opening formation accompanied by histone release from the opening is a critical step towards chromatin condensation during erythropoiesis in mice. PMID:26954545

  15. A compilation of nuclear weapons test detonation data for U.S. Pacific ocean tests.

    PubMed

    Simon, S L; Robison, W L

    1997-07-01

    Prior to December 1993, the explosive yields of 44 of 66 nuclear tests conducted by the United States in the Marshall Islands were still classified. Following a request from the Government of the Republic of the Marshall Islands to the U.S. Department of Energy to release this information, the Secretary of Energy declassified and released to the public the explosive yields of the Pacific nuclear tests. This paper presents a synopsis of information on nuclear test detonations in the Marshall Islands and other locations in the mid-Pacific including dates, explosive yields, locations, weapon placement, and summary statistics.

  16. Waste forms, packages, and seals working group summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sridhar, N.

    1995-09-01

    This article is a summary of the proceedings of a group discussion which took place at the Workshop on the Role of Natural Analogs in Geologic Disposal of High-Level Nuclear Waste in San Antonio, Texas on July 22-25, 1991. The working group concentrated on the subject of radioactive waste forms and packaging. Also included is a description of the use of natural analogs in waste packaging, container materials and waste forms.

  17. Radiation Protection Research Needs Workshop: Summary Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dewji, Shaheen A.; Davis, Jason; Hertel, Nolan E.

    In order to protect humans and the environment when using ionizing radiation for the advancement and benefit of society, accurately quantifying radiation and its potential effects remains the driver for ensuring the safety and secure use of nuclear and radiological applications of technology. In the realm of radiation protection and its various applications with the nuclear fuel cycle, (nuclear) medicine, emergency response, national defense, and space exploration, the scientific and research needs to support state and federal radiation protection needs in the United States in each of these areas are still deficient.

  18. Nuclear electric propulsion mission engineering study. Volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Results of a mission engineering analysis of nuclear-thermionic electric propulsion spacecraft for unmanned interplanetary and geocentric missions are summarized. Critical technologies associated with the development of nuclear electric propulsion (NEP) are assessed. Outer planet and comet rendezvous mission analysis, NEP stage design for geocentric and interplanetary missions, NEP system development cost and unit costs, and technology requirements for NEP stage development are studied. The NEP stage design provides both inherent reliability and high payload mass capability. The NEP stage and payload integration was found to be compatible with the space shuttle.

  19. Catalog of seismic records obtained in support of the ERDA/Nevada Operations Office, October 1963 through June 1976

    USGS Publications Warehouse

    Navarro, R.; Sembera, E.D.; Jungblut, W.L.

    1977-01-01

    The United States Geological Survey (USGS), Branch of Earthquake Hazards (BEH), Las Vegas, Nevada has provided ERDA, Nevada Operations Office, with seismic monitoring support to the underground nuclear weapons test program conducted at the Nevada Test Site (NTS) since September 1961. Activities from September 15, 1961 to September 13, 1963 are summarized in the report, "Seismic Dats Summary Nuclear Detonation Program, 1961 thru 1963", (Mickey and Shugart 1964) which lists seismic records obtained from all announced underground nuclear tests conducted during that period.

  20. 1976 annual summary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1978-03-01

    Abstracts of papers published during the previous calendar year, arranged in accordance with the project titles used in the USDOE Schedule 189 Budget Proposals, are presented. The collection of abstracts supplements the listing of papers published in the Schedule 189. The following subject areas are represented: high-energy physics; nuclear physics; basic energy sciences (nuclear science, materials sciences, solid state physics, materials chemistry); molecular, mathematical, and earth sciences (fundamental interactions, processes and techniques, mathematical and computer sciences); environmental research and development; physical and technological studies (characterization, measurement and monitoring); and nuclear research and applications.

  1. New Jersey state information handbook: Formerly Utilized Sites Remedial Action Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    Under the implied authority of the Atomic Energy Act of 1954, as amended, radiological surveys and research work has been conducted to determine radiological conditions at former MED/AEC sites. As of this time, 31 sites in 13 states have been identified that require or may require remedial action. This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by POLITECH CORPORATION to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook seriesmore » contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of New Jersey. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations. The loose-leaf format used in these volumes will allow the material to be updated periodically as the Remedial Action Program progresses.« less

  2. Electron-ion collider: The next QCD frontier: Understanding the glue that binds us all

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Accardi, A.; Albacete, J. L.; Anselmino, M.

    This White Paper presents the science case of an Electron-Ion Collider (EIC), focused on the structure and interactions of gluon-dominated matter, with the intent to articulate it to the broader nuclear science community. It was commissioned by the managements of Brookhaven National Laboratory (BNL) and Thomas Jefferson National Accelerator Facility (JLab) with the objective of presenting a summary of scientific opportunities and goals of the EIC as a follow-up to the 2007 NSAC Long Range plan. This document is a culmination of a community-wide effort in nuclear science following a series of workshops on EIC physics over the past decadesmore » and, in particular, the focused ten-week program on “Gluons and quark sea at high energies” at the Institute for Nuclear Theory in Fall 2010. It contains a brief description of a few golden physics measurements along with accelerator and detector concepts required to achieve them. It has been benefited profoundly from inputs by the users’ communities of BNL and JLab. Furthermore, this White Paper offers the promise to propel the QCD science program in the US, established with the CEBAF accelerator at JLab and the RHIC collider at BNL, to the next QCD frontier.« less

  3. Electron-ion collider: The next QCD frontier: Understanding the glue that binds us all

    DOE PAGES

    Accardi, A.; Albacete, J. L.; Anselmino, M.; ...

    2016-09-08

    This White Paper presents the science case of an Electron-Ion Collider (EIC), focused on the structure and interactions of gluon-dominated matter, with the intent to articulate it to the broader nuclear science community. It was commissioned by the managements of Brookhaven National Laboratory (BNL) and Thomas Jefferson National Accelerator Facility (JLab) with the objective of presenting a summary of scientific opportunities and goals of the EIC as a follow-up to the 2007 NSAC Long Range plan. This document is a culmination of a community-wide effort in nuclear science following a series of workshops on EIC physics over the past decadesmore » and, in particular, the focused ten-week program on “Gluons and quark sea at high energies” at the Institute for Nuclear Theory in Fall 2010. It contains a brief description of a few golden physics measurements along with accelerator and detector concepts required to achieve them. It has been benefited profoundly from inputs by the users’ communities of BNL and JLab. Furthermore, this White Paper offers the promise to propel the QCD science program in the US, established with the CEBAF accelerator at JLab and the RHIC collider at BNL, to the next QCD frontier.« less

  4. Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program

    PubMed Central

    Foti, Rossana; Gnan, Stefano; Cornacchia, Daniela; Dileep, Vishnu; Bulut-Karslioglu, Aydan; Diehl, Sarah; Buness, Andreas; Klein, Felix A.; Huber, Wolfgang; Johnstone, Ewan; Loos, Remco; Bertone, Paul; Gilbert, David M.; Manke, Thomas; Jenuwein, Thomas; Buonomo, Sara C.B.

    2016-01-01

    Summary DNA replication is temporally and spatially organized in all eukaryotes, yet the molecular control and biological function of the replication-timing program are unclear. Rif1 is required for normal genome-wide regulation of replication timing, but its molecular function is poorly understood. Here we show that in mouse embryonic stem cells, Rif1 coats late-replicating domains and, with Lamin B1, identifies most of the late-replicating genome. Rif1 is an essential determinant of replication timing of non-Lamin B1-bound late domains. We further demonstrate that Rif1 defines and restricts the interactions between replication-timing domains during the G1 phase, thereby revealing a function of Rif1 as organizer of nuclear architecture. Rif1 loss affects both number and replication-timing specificity of the interactions between replication-timing domains. In addition, during the S phase, Rif1 ensures that replication of interacting domains is temporally coordinated. In summary, our study identifies Rif1 as the molecular link between nuclear architecture and replication-timing establishment in mammals. PMID:26725008

  5. North Korea’s Nuclear Weapons: Latest Developments

    DTIC Science & Technology

    2007-12-05

    time shown less confidence about what the scope of the program might be. Further, although seismographs registered the October 9, 2006, detonation and...298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 North Korea’s Nuclear Weapons: Latest Developments Summary This report summarizes what is known from...States would lead disablement activities and provide the initial funding for those activities.15 Disablement indicates a physical measure to make it

  6. Hybridization and genome size evolution: timing and magnitude of nuclear DNA content increases in Helianthus homoploid hybrid species

    PubMed Central

    Baack, Eric J.; Whitney, Kenneth D.; Rieseberg, Loren H.

    2008-01-01

    Summary Hybridization and polyploidy can induce rapid genomic changes, including the gain or loss of DNA, but the magnitude and timing of such changes are not well understood. The homoploid hybrid system in Helianthus (three hybrid-derived species and their two parents) provides an opportunity to examine the link between hybridization and genome size changes in a replicated fashion. Flow cytometry was used to estimate the nuclear DNA content in multiple populations of three homoploid hybrid Helianthus species (Helianthus anomalus, Helianthus deserticola, and Helianthus paradoxus), the parental species (Helianthus annuus and Helianthus petiolaris), synthetic hybrids, and natural hybrid-zone populations. Results confirm that hybrid-derived species have 50% more nuclear DNA than the parental species. Despite multiple origins, hybrid species were largely consistent in their DNA content across populations, although H. deserticola showed significant interpopulation differences. First- and sixth-generation synthetic hybrids and hybrid-zone plants did not show an increase from parental DNA content. First-generation hybrids differed in DNA content according to the maternal parent. In summary, hybridization by itself does not lead to increased nuclear DNA content in Helianthus, and the evolutionary forces responsible for the repeated increases in DNA content seen in the hybrid-derived species remain mysterious. PMID:15998412

  7. Baccharis dracunculifolia-based mouthrinse alters the exopolysaccharide structure in cariogenic biofilms.

    PubMed

    Aires, Carolina P; Sassaki, Guilherme L; Santana-Filho, Arquimedes P; Spadaro, Augusto C C; Cury, Jaime A

    2016-03-01

    Baccharis dracunculifolia is a native plant from Brazil with antimicrobial activity. The purpose of this study was to investigate whether a B. dracunculifolia-based mouthrinse (Bd) changes the structure of insoluble exopolysaccharides (IEPS) in Streptococcus mutans UA159 cariogenic biofilm. Biofilms were grown on glass slides and treated with Bd, its vehicle (VC), chlorhexidine digluconate (CHX), or saline solution (NaCl). Among the treatments, only CHX significantly reduced the biofilm biomass and bacterial viability (p<0.05). Gas chromatography-mass spectrometry and nuclear magnetic resonance analyses revealed that IEPS from the four biofilm samples were α- glucans containing different proportions of (1→6) and (1→3) glycosidic linkages. The structural differences among the four IEPS were compared by principal component analysis (PCA). PCA analysis indicated that IEPS from VC- and NaCl-treated biofilms were structurally similar to each other. Compared with the control, IEPS from Bd- and CHX-treated biofilms were structurally different and had distinct chemical profiles. In summary, the fact that Bd changed the IEPS chemical composition indicates that this mouthrinse may affect the cariogenic properties of the S. mutans biofilm formed. Copyright © 2015. Published by Elsevier B.V.

  8. Quantification of the Spatial Organization of the Nuclear Lamina as a Tool for Cell Classification

    PubMed Central

    Righolt, Christiaan H.; Zatreanu, Diana A.; Raz, Vered

    2013-01-01

    The nuclear lamina is the structural scaffold of the nuclear envelope that plays multiple regulatory roles in chromatin organization and gene expression as well as a structural role in nuclear stability. The lamina proteins, also referred to as lamins, determine nuclear lamina organization and define the nuclear shape and the structural integrity of the cell nucleus. In addition, lamins are connected with both nuclear and cytoplasmic structures forming a dynamic cellular structure whose shape changes upon external and internal signals. When bound to the nuclear lamina, the lamins are mobile, have an impact on the nuclear envelop structure, and may induce changes in their regulatory functions. Changes in the nuclear lamina shape cause changes in cellular functions. A quantitative description of these structural changes could provide an unbiased description of changes in cellular function. In this review, we describe how changes in the nuclear lamina can be measured from three-dimensional images of lamins at the nuclear envelope, and we discuss how structural changes of the nuclear lamina can be used for cell classification. PMID:27335676

  9. Quantification of the Spatial Organization of the Nuclear Lamina as a Tool for Cell Classification.

    PubMed

    Righolt, Christiaan H; Zatreanu, Diana A; Raz, Vered

    2013-01-01

    The nuclear lamina is the structural scaffold of the nuclear envelope that plays multiple regulatory roles in chromatin organization and gene expression as well as a structural role in nuclear stability. The lamina proteins, also referred to as lamins, determine nuclear lamina organization and define the nuclear shape and the structural integrity of the cell nucleus. In addition, lamins are connected with both nuclear and cytoplasmic structures forming a dynamic cellular structure whose shape changes upon external and internal signals. When bound to the nuclear lamina, the lamins are mobile, have an impact on the nuclear envelop structure, and may induce changes in their regulatory functions. Changes in the nuclear lamina shape cause changes in cellular functions. A quantitative description of these structural changes could provide an unbiased description of changes in cellular function. In this review, we describe how changes in the nuclear lamina can be measured from three-dimensional images of lamins at the nuclear envelope, and we discuss how structural changes of the nuclear lamina can be used for cell classification.

  10. Probabilistic accident consequence uncertainty analysis -- Late health effects uncertain assessment. Volume 2: Appendices

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Little, M.P.; Muirhead, C.R.; Goossens, L.H.J.

    1997-12-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library ofmore » uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA late health effects models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the expert panel on late health effects, (4) short biographies of the experts, and (5) the aggregated results of their responses.« less

  11. Probabilistic accident consequence uncertainty analysis -- Uncertainty assessment for internal dosimetry. Volume 2: Appendices

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goossens, L.H.J.; Kraan, B.C.P.; Cooke, R.M.

    1998-04-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library ofmore » uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA internal dosimetry models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the panel on internal dosimetry, (4) short biographies of the experts, and (5) the aggregated results of their responses.« less

  12. Use of the Homeland-Defense Operational Planning System (HOPS) for Emergency Management

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Durling, Jr., R L; Price, D E

    2005-12-16

    The Homeland-Defense Operational Planning System (HOPS), is a new operational planning tool leveraging Lawrence Livermore National Laboratory's expertise in weapons systems and in sparse information analysis to support the defense of the U.S. homeland. HOPS provides planners with a basis to make decisions to protect against acts of terrorism, focusing on the defense of facilities critical to U.S. infrastructure. Criticality of facilities, structures, and systems is evaluated on a composite matrix of specific projected casualty, economic, and sociopolitical impact bins. Based on these criteria, significant unidentified vulnerabilities are identified and secured. To provide insight into potential successes by malevolent actors,more » HOPS analysts strive to base their efforts mainly on unclassified open-source data. However, more cooperation is needed between HOPS analysts and facility representatives to provide an advantage to those whose task is to defend these facilities. Evaluated facilities include: refineries, major ports, nuclear power plants and other nuclear licensees, dams, government installations, convention centers, sports stadiums, tourist venues, and public and freight transportation systems. A generalized summary of analyses of U.S. infrastructure facilities will be presented.« less

  13. Risk Assessment Using The Homeland-Defense Operational Planning System (HOPS)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Price, D E; Durling, R L

    2005-10-10

    The Homeland-Defense Operational Planning System (HOPS), is a new operational planning tool leveraging Lawrence Livermore National Laboratory's expertise in weapons systems and in sparse information analysis to support the defense of the U.S. homeland. HOPS provides planners with a basis to make decisions to protect against acts of terrorism, focusing on the defense of facilities critical to U.S. infrastructure. Criticality of facilities, structures, and systems is evaluated on a composite matrix of specific projected casualty, economic, and sociopolitical impact bins. Based on these criteria, significant unidentified vulnerabilities are identified and secured. To provide insight into potential successes by malevolent actors,more » HOPS analysts strive to base their efforts mainly on unclassified open-source data. However, more cooperation is needed between HOPS analysts and facility representatives to provide an advantage to those whose task is to defend these facilities. Evaluated facilities include: refineries, major ports, nuclear power plants and other nuclear licensees, dams, government installations, convention centers, sports stadiums, tourist venues, and public and freight transportation systems. A generalized summary of analyses of U.S. infrastructure facilities will be presented.« less

  14. The US nuclear reaction data network. Summary of the first meeting, March 13 & 14 1996

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-03-01

    The first meeting of the US Nuclear Reaction Data Network (USNRDN) was held at the Colorado School of Mines, March 13-14, 1996 chaired by F. Edward Cecil. The Agenda of the meeting is attached. The Network, its mission, products and services; related nuclear data and data networks, members, and organization are described in Attachment 1. The following progress reports from the members of the USNRDN were distributed prior to the meeting and are given as Attachment 2. (1) Measurements and Development of Analytic Techniques for Basic Nuclear Physics and Nuclear Applications; (2) Nuclear Reaction Data Activities at the National Nuclearmore » Data Center; (3) Studies of nuclear reactions at very low energies; (4) Nuclear Reaction Data Activities, Nuclear Data Group; (5) Progress in Neutron Physics at Los Alamos - Experiments; (6) Nuclear Reaction Data Activities in Group T2; (7) Progress Report for the US Nuclear Reaction Data Network Meeting; (8) Nuclear Astrophysics Research Group (ORNL); (9) Progress Report from Ohio University; (10) Exciton Model Phenomenology; and (11) Progress Report for Coordination Meeting USNRDN.« less

  15. National Nuclear Data Center

    Science.gov Websites

    reaction data Sigma Retrieval & Plotting Nuclear structure & decay Data Nuclear Science References Experimental Unevaluated Nuclear Data List Evaluated Nuclear Structure Data File NNDC databases Ground and isomeric states properties Nuclear structure & decay data journal Nuclear reaction model code Tools and

  16. Decontamination, decommissioning, and vendor advertorial issue, 2008

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Agnihotri, Newal

    The focus of the July-August issue is on Decontamination, decommissioning, and vendor advertorials. Articles and reports in this issue include: D and D technical paper summaries; The role of nuclear power in turbulent times, by Tom Chrisopher, AREVA, NP, Inc.; Enthusiastic about new technologies, by Jack Fuller, GE Hitachi Nuclear Energy; It's important to be good citizens, by Steve Rus, Black and Veatch Corporation; Creating Jobs in the U.S., by Guy E. Chardon, ALSTOM Power; and, and, An enviroment and a community champion, by Tyler Lamberts, Entergy Nuclear Operations, Inc. The Industry Innovations article is titled Best of the bestmore » TIP achievement 2008, by Edward Conaway, STP Nuclear Operating Company.« less

  17. IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs

    PubMed Central

    Yu, Minjia; Qian, Wen; Wang, Han; Zhou, Gao; Chen, Xing; Yang, Hui; Hong, Lingzi; Zhao, Junjie; Qin, Luke; Fukuda, Koichi; Flotho, Annette; Gao, Ji; Dongre, Ashok; Carman, Julie A; Kang, Zizhen; Su, Bing; Kern, Timothy S; Smith, Jonathan D; Hamilton, Thomas A; Melchior, Frauke; Fox, Paul L

    2017-01-01

    Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 engagement promotes nuclear localization of IRAK2 to facilitate nuclear export of a specific subset of inflammation-related mRNAs for translation in murine macrophages. IRAK2 kinase activity is required for LPS-induced RanBP2-mediated IRAK2 sumoylation and subsequent nuclear translocation. Array analysis showed that an SRSF1-binding motif is enriched in mRNAs dependent on IRAK2 for nuclear export. Nuclear IRAK2 phosphorylates SRSF1 to reduce its binding to target mRNAs, which promotes the RNA binding of the nuclear export adaptor ALYREF and nuclear export receptor Nxf1 loading for the export of the mRNAs. In summary, LPS activates a nuclear function of IRAK2 that facilitates the assembly of nuclear export machinery to export selected inflammatory mRNAs to the cytoplasm for translation. PMID:28990926

  18. IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.

    PubMed

    Zhou, Hao; Bulek, Katarzyna; Li, Xiao; Herjan, Tomasz; Yu, Minjia; Qian, Wen; Wang, Han; Zhou, Gao; Chen, Xing; Yang, Hui; Hong, Lingzi; Zhao, Junjie; Qin, Luke; Fukuda, Koichi; Flotho, Annette; Gao, Ji; Dongre, Ashok; Carman, Julie A; Kang, Zizhen; Su, Bing; Kern, Timothy S; Smith, Jonathan D; Hamilton, Thomas A; Melchior, Frauke; Fox, Paul L; Li, Xiaoxia

    2017-10-09

    Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 engagement promotes nuclear localization of IRAK2 to facilitate nuclear export of a specific subset of inflammation-related mRNAs for translation in murine macrophages. IRAK2 kinase activity is required for LPS-induced RanBP2-mediated IRAK2 sumoylation and subsequent nuclear translocation. Array analysis showed that an SRSF1-binding motif is enriched in mRNAs dependent on IRAK2 for nuclear export. Nuclear IRAK2 phosphorylates SRSF1 to reduce its binding to target mRNAs, which promotes the RNA binding of the nuclear export adaptor ALYREF and nuclear export receptor Nxf1 loading for the export of the mRNAs. In summary, LPS activates a nuclear function of IRAK2 that facilitates the assembly of nuclear export machinery to export selected inflammatory mRNAs to the cytoplasm for translation.

  19. Conceptual design studies and experiments related to cavity exhaust systems for nuclear light bulb configurations

    NASA Technical Reports Server (NTRS)

    Kendall, J. S.; Stoeffler, R. C.

    1972-01-01

    Investigations of various phases of gaseous nuclear rocket technology have been conducted. The principal research efforts have recently been directed toward the closed-cycle, vortex-stabilized nuclear light bulb engine and toward a small-scale fissioning uranium plasma experiment that could be conducted in the Los Alamos Scientific Laboratory's Nuclear Furnace. The engine concept is based on the transfer of energy by thermal radiation from gaseous fissioning uranium, through a transparent wall, to hydrogen propellant. The reference engine configuration is comprised of seven unit cavities, each having its own fuel transparent wall and propellant duct. The basic design of the engine is described. Subsequent studies performed to supplement and investigate the basic design are reported. Summaries of other nuclear light bulb research programs are included.

  20. Chemical, biological, radiological and nuclear terrorism: an introduction for occupational physicians.

    PubMed

    Thornton, R; Court, B; Meara, J; Murray, V; Palmer, I; Scott, R; Wale, M; Wright, D

    2004-03-01

    Chemical, biological, radiological and nuclear terrorism poses considerable threat throughout the world. To provide occupational physicians with an understanding of this threat and its main forms and what action can be taken to counter this threat. Presenters at a conference on chemical, biological, radiological and nuclear terrorism were asked to contribute their evidence-based opinions in order to produce a review article. This paper presents a summary of the different forms of chemical, biological, radiological and nuclear terrorism and the effective counter-measures and also provides a review of current scientific literature. The threat of chemical, biological, radiological and nuclear terrorism is present throughout the world and is one that occupational physicians should be aware of, as well as the action that can be taken to counter it.

  1. Manned space flight nuclear system safety. Volume 6: Space base nuclear system safety plan

    NASA Technical Reports Server (NTRS)

    1972-01-01

    A qualitative identification of the steps required to assure the incorporation of radiological system safety principles and objectives into all phases of a manned space base program are presented. Specific areas of emphasis include: (1) radiological program management, (2) nuclear system safety plan implementation, (3) impact on program, and (4) summary of the key operation and design guidelines and requirements. The plan clearly indicates the necessity of considering and implementing radiological system safety recommendations as early as possible in the development cycle to assure maximum safety and minimize the impact on design and mission plans.

  2. ALL-UNION CONFERENCE ON APPLICATIONS OF RADIOACTIVE ISOTOPES AND NUCLEAR EMISSIONS IN THE NATIONAL INDUSTRY OF USSR (in Russian)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1960-09-01

    Papers presented at the All-Union Conference on Industrial Applications of Radioactive Isotopes and Nuclear Emissions in the National Economy of USSR, April 12 to 16, 1960, in Riga are surveyed. Short summaries are given on applications of radioactive isotopes and nuclear emissions in prospecting, developing mineral resources, metallurgy, ore enrichment processes, machine construction technology, agriculture, food processing, and medicine. Sources of alpha , beta , and gamma radiation for control and automation of processes are also discussed. The full reports from the conference will be published in 1960. (R.V.J.)

  3. Skill Transfer and Virtual Training for IND Response Decision-Making: Analysis of Decision-Making Skills for Large Scale Incidents

    DTIC Science & Technology

    2016-01-01

    issues comes from the Fukushima Daiichi nuclear disaster (2011). The local medical health professional on staff at the U.S. embassy in Tokyo was not...distribution unlimited. This page intentionally left blank. iii EXECUTIVE SUMMARY An improvised nuclear device (IND...from the phase one analysis are as follows : • There is strong consistency in both the key decisions and underlying skills emphasized by emergency

  4. Minute gun series: Diana mist event. Project officers report (sanitized version). Summary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schiff, A.T.; Tiano, D.E.

    1971-12-27

    Diana Mist was a Department of Defense underground nuclear test executed on 11 February 1970 in the n.06 drift of the U12n tunnel complex. Test chambers were located in an evacuated horizontal line-of-sight pipe at 400, 640, 755, 905, and 1110 feet from the nuclear source. The objectives of practically all other experiments were achieved through active measurements and/or posttest examination.

  5. North Korea’s Nuclear Weapons: Latest Developments

    DTIC Science & Technology

    2007-11-21

    time shown less confidence about what the scope of the program might be. Further, although seismographs registered the October 9, 2006, detonation...298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 North Korea’s Nuclear Weapons: Latest Developments Summary This report summarizes what is known from...provide the initial funding for those activities.15 Disablement indicates a physical measure to make it difficult to restart operation of a facility while

  6. Summary of measurements of high-LET particle radiation in U.S. manned space missions.

    PubMed

    Benton, E V; Peterson, D D; Henke, R P

    1977-01-01

    A summary of measurements of high-LET particle radiation inside U.S. manned spacecraft is given for ASTP (Apollo Soyuz Test Project), Skylab and Apollo missions. The results include particle fluxes, integral LET spectra, and stopping-density charge distributions derived from measurements made in plastic nuclear track detectors worn by astronauts and located at various positions inside spacecraft. The results presented for different missions cover a wide range of shielding depth and missions type.

  7. Characterization of alternative electric generation technologies for the SPS comparative assessment. Volume 1: Summary of central station technologies

    NASA Astrophysics Data System (ADS)

    1980-08-01

    The technologies selected for the detailed characterization were: solar technology; terrestrial photovoltaic (200 MWe); coal technologies; conventional high sulfur coal combustion with advanced fine gas desulfurization (1250 MWe), and open cycle gas turbine combined cycle plant with low Btu gasifier (1250 MWe); and nuclear technologies: conventional light water reactor (1250 MWe), liquid metal fast breeder reactor (1250 MWe), and magnetic fusion reactor (1320 MWe). A brief technical summary of each power plant design is given.

  8. Current experiments in elementary particle physics. Revised

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Galic, H.; Wohl, C.G.; Armstrong, B.

    This report contains summaries of 584 current and recent experiments in elementary particle physics. Experiments that finished taking data before 1986 are excluded. Included are experiments at Brookhaven, CERN, CESR, DESY, Fermilab, Tokyo Institute of Nuclear Studies, Moscow Institute of Theoretical and Experimental Physics, KEK, LAMPF, Novosibirsk, Paul Scherrer Institut (PSI), Saclay, Serpukhov, SLAC, SSCL, and TRIUMF, and also several underground and underwater experiments. Instructions are given for remote searching of the computer database (maintained under the SLAC/SPIRES system) that contains the summaries.

  9. Volcanism/tectonics working group summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kovach, L.A.

    1995-09-01

    This article is a summary of the proceedings of a group discussion which took place at the Workshop on the Role of Natural Analogs in Geologic Disposal of High-Level Nuclear Waste in San Antonio, Texas on July 22-25, 1991. The working group concentrated on the subject of the impacts of earthquakes, fault rupture, and volcanic eruption on the underground repository disposal of high-level radioactive wastes. The tectonics and seismic history of the Yucca Mountain site in Nevada is discussed and geologic analogs to that site are described.

  10. NASA Reactor Facility Hazards Summary. Volume 2

    NASA Technical Reports Server (NTRS)

    1959-01-01

    Supplements to volume 1 are presented herein. Included in these papers are information unavailable when volume 1 was written, an evaluation of the proposed nuclear facility, and answers to questions raised by the AEC concerning volume 1.

  11. 76 FR 17407 - Proposed Subsequent Arrangement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-29

    ... United States of America and the Argentine Republic Concerning Peaceful Uses of Nuclear Energy. DATES... DEPARTMENT OF ENERGY Proposed Subsequent Arrangement AGENCY: Office of Nonproliferation and International Security, Department of Energy. ACTION: Proposed subsequent arrangement. SUMMARY: This notice is...

  12. 75 FR 81593 - Proposed Subsequent Arrangement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... Institute of Nuclear Energy Research, Lungtan, Taiwan. The facility is hereby found acceptable to both... DEPARTMENT OF ENERGY Proposed Subsequent Arrangement AGENCY: Office of Nonproliferation and International Security, Department of Energy. ACTION: Proposed subsequent arrangement. SUMMARY: Pursuant to...

  13. Oak Ridge National Laboratory Health and Safety Long-Range Plan: Fiscal years 1989--1995

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1989-06-01

    The health and safety of its personnel is the first concern of ORNL and its management. The ORNL Health and Safety Program has the responsibility for ensuring the health and safety of all individuals assigned to ORNL activities. This document outlines the principal aspects of the ORNL Health and Safety Long-Range Plan and provides a framework for management use in the future development of the health and safety program. Each section of this document is dedicated to one of the health and safety functions (i.e., health physics, industrial hygiene, occupational medicine, industrial safety, nuclear criticality safety, nuclear facility safety, transportationmore » safety, fire protection, and emergency preparedness). Each section includes functional mission and objectives, program requirements and status, a summary of program needs, and program data and funding summary. Highlights of FY 1988 are included.« less

  14. Second NBL measurement evaluation program meeting: A summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spaletto, M.I.; Clapper, M.; Tolbert, M.E.M.

    New Brunswick Laboratory (NBL), the US government`s nuclear materials measurements and reference materials laboratory, administers interlaboratory measurement evaluation programs to evaluate the quality and adequacy of safeguards measurements. The NBL Measurement Evaluation Program covers several types of safeguards analytical measurements. The Safeguards Measurement Evaluation (SME) program distributes test materials destructive measurements of uranium for both elemental concentration and isotopic abundances, and of plutonium for isotopic abundances. The Calorimetry Exchange (CalEx) Program tests the quality of nondestructive measurements of plutonium isotopic abundances by gamma spectroscopy and plutonium concentration by calorimetry. In May 1997, more than 30 representatives from the Department ofmore » Energy (DOE), its contractor laboratories, and Nuclear Regulatory Commission licensees met at NBL in Argonne, Illinois, for the annual meeting of the Measurement Evaluation Program. The summary which follows details key points that were discussed or presented at the meeting.« less

  15. Induced Star Formation

    NASA Astrophysics Data System (ADS)

    Kennicutt, Robert C., Jr.

    Overview: Induced Star Formation and Interactions Introduction Historical Background: First Hints Systematic Studies: Starbursts Interactions and Nuclear activity IRAS and Ultralumious starburst Galaxies The 1990's: HST, Supercomputers, and the Distant Universe Key Questions and Issues Organization of Lectures Star Formation Properties of Normal Galaxies Observational Techniques Results: Star Formation in Normal Galaxies Interpretation: Star Formation Histories Global Star Formation in interacting Galaxies A Gallery of Interactions and Mergers Star Formation Statistics: Guilt By Association Tests SFRs in Interacting vs Noninteracting Galaxies Kinematic Properties and Regulation of SFRs Induced Nuclear Activity and Star Formation Background: Nuclear Spectra and Classification Nuclear Star Formation and Starbursts Nuclear Star Formation and Interactions Induced AGN Activity: Statistics of Seyfert Galaxies Environments of Quasars Kinematic Clues to the Triggering of AGNs Infrared Luminous Galaxies and Starbursts Background: IR Luminous Galaxies and IRAS Infrared Luminosity Function and Spectra Infrared Structure and Morphology Interstellar Gas X-Ray Emission and Superwinds Optical, UV, and Near-Infrared Spectra Radio Continuum Emission Evidence for Interactions and Mergers The Power Source: Starbursts or Dusty AGNs? Spectral Diagnostics of Starbursts Evolutionary Synthesis Models Applications: Integrated Colors of Interacting Galaxies Applications: Hα Emission, Colors, and SFRs Applications: Spectral Modelling of Evolved Starbursts Infrared Starbursts and the IMF in starbursts Triggering and Regulation of Star Formation: The Problem Introduction: Star Formation as a Nonlinear Process The schmidt Law in Normal Galaxies Star Formation Regimes in Interacting Galaxies Summary Triggering and Regulation of Starbusts: Theoretical Ideas Gravitational Star Formation Thresholds Cloud Collision Models Radial Transport of Gas: Clues from Barred Galaxies Simulations of Starbursts in Merging Galaxies The Cosmological Role of Interactions and Starbursts Interactions in Hierarchical Cosmology Interaction-Induced Star Formation Today Interaction-Induced Star Formation in the Past Disk kinematics and the Merger Rate Global Effects of Starbursts and Superwinds Concluding Remarks References

  16. Highlights lecture EANM 2014: "Gimme gimme gimme those nuclear Super Troupers".

    PubMed

    de Jong, Marion; Van Laere, Koen

    2015-04-01

    The EANM Congress 2014 took place in Gothenburg, Sweden, from 18 to 22 October under the presidency of Prof. Wim Oyen, chair of the EANM Scientific Committee. Prof. Peter Gjertsson chaired the Local Organizing Committee, according to the standardized EANM congress structure. The meeting was a highlight for the multidisciplinary community that forms the heart and soul of nuclear medicine; attendance was exceptionally high. In total almost 5,300 participants came to Gothenburg, and 1,397 colleagues participated via the EANM LIVE sessions ( http://eanmlive.eanm.org/index.php ). Participants from all continents were presented with an excellent programme consisting of symposia, scientific and featured sessions, CME sessions, and plenary lectures. These lectures were devoted to nuclear medicine therapy, hybrid imaging and molecular life sciences. Two tracks were included in the main programme, clustering multi-committee involvement: the 5th International Symposium on Targeted Radionuclide-therapy and Dosimetry (ISTARD) and the first Molecules to Man (M2M) track, an initiative of the EANM Committees for Translational Molecular Imaging, Radiopharmacy and Drug Development. The industry made a substantial contribution to the success of the congress demonstrating the latest technology and innovations in the field. During the closing Highlights Lecture, a selection of the best-rated abstracts was presented including diverse areas of nuclear medicine: physics and instrumentation, radiopharmacy, preclinical imaging, oncology (with a focus on the clinical application of newly developed tracers) and radionuclide therapy, cardiology and neurosciences. This Highlights Lecture could only be a brief summary of the large amount of data presented and discussed during the meeting, which can be found in much greater detail in the congress proceedings book, published as Volume 41, Supplement 2 of the European Journal of Nuclear Medicine and Molecular Imaging in October 2014.

  17. Cancer Risk Associated with Nuclear Atypia in Cytologically Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis.

    PubMed

    Valderrabano, Pablo; Khazai, Laila; Thompson, Zachary J; Sharpe, Susan C; Tarasova, Valentina D; Otto, Kristen J; Hallanger-Johnson, Julie E; Wadsworth, J Trad; Wenig, Bruce M; Chung, Christine H; Centeno, Barbara A; McIver, Bryan

    2018-02-01

    Indeterminate categories of thyroid cytopathology (categories B-III and B-IV of the Bethesda system) are integrated by a heterogeneous spectrum of cytological scenarios that are generally clustered for analysis and management recommendations. It has been suggested that aspirates exhibiting nuclear atypia have a higher risk of malignancy. This study aimed to assess whether cytologically indeterminate thyroid nodules with nuclear atypia have a significantly higher cancer risk than those without nuclear atypia. On June 30, 2016, PubMed and EMBASE were searched for articles in English or Spanish using a search strategy developed by an endocrinologist and a librarian. Case reports were excluded, and no date limits were used. The references of all included studies were also screened for relevant missing studies. Studies were included if the prevalences of malignancy of cytologically indeterminate thyroid nodules with histological confirmation with and without nuclear atypia were reported. Studies were excluded if they had: (i) nodules suspicious for malignancy; (ii) nodules with non-indeterminate (B-III or B-IV) cytology on repeated biopsy, if performed; (iii) nodules not consecutively evaluated; or (iv) cohorts overlapping with another larger series. Two investigators independently assessed the eligibility and risk of bias of the studies. PRISMA and MOOSE guidelines were followed. Summary data were extracted from published reports by one investigator and independently reviewed by another. Data were pooled using a random-effects model. Heterogeneity was explored using subgroup analysis and mixed-effect model meta-regression. The odds ratio for malignancy of cytologically indeterminate thyroid nodules with nuclear atypia over cytologically indeterminate thyroid nodules without nuclear atypia was calculated. Of 2571 retrieved studies, 20 were eligible. The meta-analysis was conducted on summary data of 3532 cytologically indeterminate thyroid nodules: 1162 with and 2370 without nuclear atypia. The odds ratio for malignancy in cytologically indeterminate thyroid nodules with nuclear atypia was 3.63 [confidence interval 3.06-4.35]. There was no evidence of publication bias, and heterogeneity was insignificant (I 2 < 0.01%, p = 0.40). Nuclear atypia is a significant indicator of malignancy in cytologically indeterminate thyroid nodules and needs to be standardized and implemented into clinical practice.

  18. Nuclear-effects model embedded stochastically in simulation (NEMESIS) summary report. Technical paper

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Youngren, M.A.

    1989-11-01

    An analytic probability model of tactical nuclear warfare in the theater is presented in this paper. The model addresses major problems associated with representing nuclear warfare in the theater. Current theater representations of a potential nuclear battlefield are developed in context of low-resolution, theater-level models or scenarios. These models or scenarios provide insufficient resolution in time and space for modeling a nuclear exchange. The model presented in this paper handles the spatial uncertainty in potentially targeted unit locations by proposing two-dimensional multivariate probability models for the actual and perceived locations of units subordinate to the major (division-level) units represented inmore » theater scenarios. The temporal uncertainty in the activities of interest represented in our theater-level Force Evaluation Model (FORCEM) is handled through probability models of the acquisition and movement of potential nuclear target units.« less

  19. Applications of nuclear physics

    NASA Astrophysics Data System (ADS)

    Hayes, A. C.

    2017-02-01

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applications of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.

  20. Applications of nuclear physics

    DOE PAGES

    Hayes-Sterbenz, Anna Catherine

    2017-01-10

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applicationsmore » of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Lastly, each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.« less

  1. Applications of nuclear physics.

    PubMed

    Hayes, A C

    2017-02-01

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applications of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.

  2. Applications of nuclear physics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hayes-Sterbenz, Anna Catherine

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applicationsmore » of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Lastly, each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.« less

  3. Peroxisome proliferator-activated receptors for hypertension

    PubMed Central

    Usuda, Daisuke; Kanda, Tsugiyasu

    2014-01-01

    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear receptor superfamily, which is composed of four members encoded by distinct genes (α, β, γ, and δ). The genes undergo transactivation or transrepression under specific mechanisms that lead to the induction or repression of target gene expression. As is the case with other nuclear receptors, all four PPAR isoforms contain five or six structural regions in four functional domains; namely, A/B, C, D, and E/F. PPARs have many functions, particularly functions involving control of vascular tone, inflammation, and energy homeostasis, and are, therefore, important targets for hypertension, obesity, obesity-induced inflammation, and metabolic syndrome in general. Hence, PPARs also represent drug targets, and PPARα and PPARγ agonists are used clinically in the treatment of dyslipidemia and type 2 diabetes mellitus, respectively. Because of their pleiotropic effects, they have been identified as active in a number of diseases and are targets for the development of a broad range of therapies for a variety of diseases. It is likely that the range of PPARγ agonist therapeutic actions will result in novel approaches to lifestyle and other diseases. The combination of PPARs with reagents or with other cardiovascular drugs, such as diuretics and angiotensin II receptor blockers, should be studied. This article provides a review of PPAR isoform characteristics, a discussion of progress in our understanding of the biological actions of PPARs, and a summary of PPAR agonist development for patient management. We also include a summary of the experimental and clinical evidence obtained from animal studies and clinical trials conducted to evaluate the usefulness and effectiveness of PPAR agonists in the treatment of lifestyle-related diseases. PMID:25228953

  4. Report on Activities and Programs for Countering Proliferation and NBC Terrorism. Volume 1. Executive Summary

    DTIC Science & Technology

    2011-05-01

    Homeland Security (DHS) and the Department of State (DOS), and by changing the IC’s CPRC representative from the Director of Central Intelli- gence to the...Security Strategy of the United States of America (May 2010), p. 4. 2 Nuclear Posture Review Report (April 6, 2010), p. i 3 National Strategy for...ongoing efforts with GICNT, the Nuclear Forensics International Technical Working Group (ITWG), Forensics En - gagement Working Group (FEWG), NATO

  5. Guide for Operational Configuration Management Program including the adjunct programs of design reconstitution and material condition and aging management. Part 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This standard presents program criteria and implementation guidance for an operational configuration management program for DOE nuclear and non-nuclear facilities. This Part 2 includes chapters on implementation guidance for operational configuration management, implementation guidance for design reconstitution, and implementation guidance for material condition and aging management. Appendices are included on design control, examples of design information, conduct of walkdowns, and content of design information summaries.

  6. Operation TOMODACHI: A Model for American Disaster Response Efforts and the Collective use of Military Forces Abroad

    DTIC Science & Technology

    2012-01-01

    Plant in Fukushima Daiichi (approximately 170 miles North of Tokyo). The plant consisted of six nuclear reactors and a series of spent-fuel pools...should be praised for the decision to allow family members to voluntarily evacuate areas within 200 miles of the Fukushima - Daiichi Nuclear Plant... Disaster ” (power point presentation, Airlift Tanker Association, Nashville, TN, November 4, 2011) 3 Hisaya Sugiyama, “AIA Summary of Fukushima

  7. Amarillo National Resource Center for Plutonium. Quarterly technical progress report, May 1, 1997--July 31, 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    Progress summaries are provided from the Amarillo National Center for Plutonium. Programs include the plutonium information resource center, environment, public health, and safety, education and training, nuclear and other material studies.

  8. Women in Physics.

    ERIC Educational Resources Information Center

    Roth, Laura M.; O'Fallon, Nancy M.

    This booklet presents information about career opportunities for women in physics. Included are summaries of research areas in physics (optical physics, solid-state physics, materials science, nuclear physics, high-energy physics, astrophysics, cryogenics, plasma physics, biophysics, atmospheric physics) and differences between theory and…

  9. 75 FR 82005 - Proposed Subsequent Arrangement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... Cooperation Concerning Civil Uses of Nuclear Energy Between the Government of the United States of America and... DEPARTMENT OF ENERGY Proposed Subsequent Arrangement AGENCY: Office of Nonproliferation and International Security, Department of Energy. ACTION: Proposed subsequent arrangement. SUMMARY: This notice is...

  10. Dynamic Assembly of Brambleberry Mediates Nuclear Envelope Fusion during Early Development

    PubMed Central

    Abrams, Elliott W.; Zhang, Hong; Marlow, Florence L.; Kapp, Lee; Lu, Sumei; Mullins, Mary C.

    2012-01-01

    Summary To accommodate the large cells following zygote formation, early blastomeres employ modified cell divisions. Karyomeres are one such modification, a mitotic intermediate wherein individual chromatin masses are surrounded by nuclear envelope, which then fuse to form a single mononucleus. We identified brambleberry, a maternal-effect zebrafish mutant that disrupts karyomere fusion resulting in formation of multiple micronuclei. brambleberry is a previously unannotated gene homologous to Kar5p, which participates in nuclear fusion in yeast. We demonstrate that Brambleberry is required for pronuclear fusion following fertilization in zebrafish. As karyomeres form, Brambleberry localizes to the nuclear envelope with prominent puncta evident near karyomere-karyomere interfaces corresponding to membrane fusion sites. Our studies identify the first factor acting in karyomere fusion and suggest that specialized proteins are necessary for proper nuclear division in large dividing blastomeres. PMID:22863006

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kornreich, Drew E; Vaidya, Rajendra U; Ammerman, Curtt N

    Integrated Computational Materials Engineering (ICME) is a novel overarching approach to bridge length and time scales in computational materials science and engineering. This approach integrates all elements of multi-scale modeling (including various empirical and science-based models) with materials informatics to provide users the opportunity to tailor material selections based on stringent application needs. Typically, materials engineering has focused on structural requirements (stress, strain, modulus, fracture toughness etc.) while multi-scale modeling has been science focused (mechanical threshold strength model, grain-size models, solid-solution strengthening models etc.). Materials informatics (mechanical property inventories) on the other hand, is extensively data focused. All of thesemore » elements are combined within the framework of ICME to create architecture for the development, selection and design new composite materials for challenging environments. We propose development of the foundations for applying ICME to composite materials development for nuclear and high-radiation environments (including nuclear-fusion energy reactors, nuclear-fission reactors, and accelerators). We expect to combine all elements of current material models (including thermo-mechanical and finite-element models) into the ICME framework. This will be accomplished through the use of a various mathematical modeling constructs. These constructs will allow the integration of constituent models, which in tum would allow us to use the adaptive strengths of using a combinatorial scheme (fabrication and computational) for creating new composite materials. A sample problem where these concepts are used is provided in this summary.« less

  12. Nuclear Energy Present and Future

    NASA Astrophysics Data System (ADS)

    Hutchinson, I. H.

    2006-10-01

    Nuclear power plants currently generate about 20% of US and 17% of world electricity, which makes nuclear the largest non-emitting energy source in current use. Concerns about global climate change have led to a remarkable transformation of attitudes towards nuclear energy. There remain key challenges that must be faced when considering expansion of its contribution. In summary they are: Economics, Safety, Waste Disposal, and Proliferation. Electricity from legacy fission plants is highly competitive with fossil, but perceived financial risks make the large capital cost fraction a key hurdle to new-construction, and costs of 2 per installed Watt electrical are currently considered only just economically attractive. Proliferation of nuclear-weapons-enabling technology is a major concern for global stability, in which fusion may have significant technical advantages over fission. But proliferation control requires a combination of both technical and political initiatives. The feasibility of supplying process heat or hydrogen from nuclear energy inspires additional research into novel reactor concepts and associated technologies. The presentation will lay out this overall context of the nuclear energy renaissance.

  13. Nuclear Data Networks

    Science.gov Websites

    calibrations. NSDD The international network of Nuclear Structure and Decay Data evaluators Group of and updating of nuclear structure data contained in Evaluated Nuclear Structure Data File (ENSDF

  14. Nuclear Thermal Propulsion Technology - Summary of FY 1991 Interagency Panel Planning

    NASA Technical Reports Server (NTRS)

    Clark, John S.; Mcdaniel, Patrick; Howe, Steven; Stanley, Marland

    1991-01-01

    An Interagency (NASA/DOE/DOD) technical panel has been working in 1991 to evaluate nuclear thermal propulsion (NTP) concepts on a consistent basis, and to continue technology development project planning for a joint project in nuclear propulsion for Space Exploration Initiative (SEI). This paper summarizes the efforts of the panel to date and summarizes the technology plans defined for NTP. Concepts were categorized based on probable technology readiness data, and innovative 'proof-of-concept' tests and analyses were defined. While further studies will be required to provide a consistent comparison of all of the NTP concepts, the current status of the studies is presented.

  15. Inspection applications with higher electron beam energies

    NASA Astrophysics Data System (ADS)

    Norman, D. R.; Jones, J. L.; Yoon, W. Y.; Haskell, K. J.; Sterbentz, J. W.; Zabriskie, J. M.; Hunt, A. W.; Harmon, F.; Kinlaw, M. T.

    2005-12-01

    The Idaho National Laboratory has developed prototype shielded nuclear material detection systems based on pulsed photonuclear assessment (PPA) techniques for the inspection of cargo containers. During this work, increased nuclear material detection capabilities have been demonstrated at higher electron beam energies than those allowed by federal regulations for cargo inspection. This paper gives a general overview of a nuclear material detection system, the PPA technique and discusses the benefits of using these higher energies. This paper also includes a summary of the numerical and test results from LINAC operations up to 24 MeV and discusses some of the federal energy limitations associated with cargo inspection.

  16. Overview of computational structural methods for modern military aircraft

    NASA Technical Reports Server (NTRS)

    Kudva, J. N.

    1992-01-01

    Computational structural methods are essential for designing modern military aircraft. This briefing deals with computational structural methods (CSM) currently used. First a brief summary of modern day aircraft structural design procedures is presented. Following this, several ongoing CSM related projects at Northrop are discussed. Finally, shortcomings in this area, future requirements, and summary remarks are given.

  17. Idaho National Laboratory Mission Accomplishments, Fiscal Year 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Allen, Todd Randall; Wright, Virginia Latta

    A summary of mission accomplishments for the research organizations at the Idaho National Laboratory for FY 2015. Areas include Nuclear Energy, National and Homeland Security, Science and Technology Addressing Broad DOE Missions; Collaborations; and Stewardship and Operation of Research Facilities.

  18. 75 FR 4545 - Proposed Subsequent Arrangement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ... Energy and the Agreement for Cooperation in the Peaceful Uses of Nuclear Energy between the United States... DEPARTMENT OF ENERGY Proposed Subsequent Arrangement AGENCY: Office of International Regimes and Agreements, Department of Energy. ACTION: Subsequent arrangement. SUMMARY: This notice has been issued under...

  19. 75 FR 12738 - Proposed Subsequent Arrangement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... Energy and the Agreement for Cooperation in the Peaceful Uses of Nuclear Energy Between the United States... DEPARTMENT OF ENERGY Proposed Subsequent Arrangement AGENCY: Office of International Regimes and Agreements, Department of Energy. ACTION: Subsequent arrangement. SUMMARY: This notice has been issued under...

  20. 75 FR 4545 - Proposed Subsequent Arrangement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ... Energy and the Agreement for Cooperation in the Peaceful Uses of Nuclear Energy between the United States... DEPARTMENT OF ENERGY Proposed Subsequent Arrangement AGENCY: Office of International Regimes and Agreements, Department of Energy. ACTION: Subsequent Arrangement. SUMMARY: This notice has been issued under...

  1. 75 FR 6408 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... (NRC) Regulatory Issue Summary 2003-18 Supplement 2, ``Use of Nuclear Energy Institute (NEI) 99-01... with 10 CFR 51.22. Therefore, pursuant to 10 CFR 51.22(b), no environmental impact statement or...

  2. Disarmament, Security and Development

    ERIC Educational Resources Information Center

    Bulletin of the Atomic Scientists, 1976

    1976-01-01

    Provided is a summary of the 26th Pugwash Conference on Science and World Affairs held August 26-31, 1976, in Muhlhausen, East Germany. World problems discussed included: arms limitations, military research and development, nuclear test ban, alternative energy sources, and genetic engineering. (SL)

  3. IDA Gamma-Ray Laser Annual Summary Report (1985). Investigation of the Feasibility of Developing a Laser Using Nuclear Transitions. Revised.

    DTIC Science & Technology

    1986-06-01

    beams of coherent radiation whose short wavelengths would permit greater penetration of matter than is possible with current laser sources. With that...nuclear linewidth. It is claimed that the time required for any narrowing is at least as long as the inverse of the linewidth achieved, no matter what...with the re- quired narrow line can be prepared is a different matter . The point is that the previous uncertainty principle does not forbid the

  4. Thirteen nuclear microsatellite loci for butternut (Juglans cinerea L.).

    PubMed

    Hoban, Sean; Anderson, Robert; McCleary, Tim; Schlarbaum, Scott; Romero-Severson, Jeanne

    2008-05-01

    Butternut (Juglans cinerea L.) is an eastern North American forest tree severely threatened by an exotic fungal pathogen, Sirococcus clavigignenti-juglandacearum. We report here 13 nuclear microsatellites for genetic evaluation of the remaining natural populations. Summary statistics are reported for individuals from a population of butternuts in central Kentucky (N = 63). All markers were polymorphic, with an average of 13.7 alleles per locus observed. Four loci exhibited significantly fewer heterozygotes than expected under Hardy-Weinberg equilibrium (P < 0.05). © 2007 The Authors.

  5. Advanced Fuels Campaign FY 2015 Accomplishments Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Braase, Lori Ann; Carmack, William Jonathan

    2015-10-29

    The mission of the Advanced Fuels Campaign (AFC) is to perform research, development, and demonstration (RD&D) activities for advanced fuel forms (including cladding) to enhance the performance and safety of the nation’s current and future reactors; enhance proliferation resistance of nuclear fuel; effectively utilize nuclear energy resources; and address the longer-term waste management challenges. This report is a compilation of technical accomplishment summaries for FY-15. Emphasis is on advanced accident-tolerant LWR fuel systems, advanced transmutation fuels technologies, and capability development.

  6. Analysis of space systems study for the space disposal of nuclear waste. Study report, volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Space systems concepts were identified and defined and evaluated as to their performance, risks, and technical viability in order to select the most attractive approach for disposal of high level nuclear wastes in space. Major study areas discussed include: (1) mission and operations analysis; (2) waste payload systems; (3) flight support system; (4) launch site systems; (5) launch vehicle systems; (6) orbit transfer system; (7) space disposal destinations; and (8) systems integration and evaluation.

  7. Radioactive materials released from nuclear power plants. Volume 13, Annual report 1992

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tichler, J.; Doty, K.; Lucadamo, K.

    Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1992 have been compiled and reported. The summary data for the years 1973 through 1991 are included for comparison. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1992 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

  8. Radioactive materials released from nuclear power plants. Annual report 1989: Volume 10

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tichler, J.; Norden, K.; Congemi, J.

    Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1989 have been compiled and reported. The summary data for the years 1970 through 1988 are included for comparison. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1989 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

  9. Radioactive materials released from nuclear power plants: Annual report, 1993. Volume 14

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tichler, J.; Doty, K.; Lucadamo, K.

    Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1993 have been compiled and reported. The summary data for the years 1974 through 1992 are included for comparison. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1993 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

  10. International Symposium on Radiation Physics: Summary Transactions (5th) Held in Dubrovnik, Croatia, Yugoslavia on 10-14 June 1991

    DTIC Science & Technology

    1991-06-01

    carried out and planned is given. IP-VI-4 NEUTRINO RADIATION FROM SUPERNOVAE J.A. Grifols Grup de Fisica Teorica, Universitat Autonoma de Barcelona 08193...and Pedro Gonzdlez. Instituto Nacional de Investigaciones Nucleares (ININ) Carretera M~xico-Toluca, Km. 36.5 Salazar, Mdxico. Three important...ments made with LiF:Mg,Cu,P prepared at the Instituto Nacio- nal de Investigaciones Nucleares (ININ) are presented in this paper. These results have

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carla J. Miller

    This report provides a summary of the literature review that was performed and based on previous work performed at the Idaho National Laboratory studying the Three Mile Island 2 (TMI-2) nuclear reactor accident, specifically the melted fuel debris. The purpose of the literature review was to document prior published work that supports the feasibility of the analytical techniques that were developed to provide quantitative results of the make-up of the fuel and reactor component debris located inside and outside the containment. The quantitative analysis provides a technique to perform nuclear fuel accountancy measurements

  12. IDA Gamma-Ray Laser Annual Summary Report (1990): Investigation of the Feasibility of Developing A Laser Using Nuclear Transitions

    DTIC Science & Technology

    1992-04-01

    Broadening in the Theory of Superradiant Emission," Acta Physica Polonica , Vol. A39, 1971, pp. 633-638. 8. B. Balko, I.W. Kay, and J. Neuberger, IDA...Cuopy 1 3 of 60 copies AD-A259 475 IDA PAPER P-2533 IDA GAMMA-RAY LASER ANNUAL SUMMARY REPORT (1990) Investigation of the Feasibility of Developing a ...embody results of major projects which ( a ) have a direct bearing on decisions affecting major programs, (b) address issues of significant concern to

  13. Arms control and the 1990 NPT review conference: Workshop summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pilat, J.F.

    1990-07-01

    The Center for National Security Studies of the Los Alamos National Laboratory and the Department of Energy's Office of Arms Control held a workshop on Arms Control and the 1990 NPT Review Conference'' on December 5--6, 1989, at Los Alamos. The fundamental objective of the Treaty on the Nonproliferation of Nuclear Weapons (NPT) is to prevent the spread of nuclear weapons to states that do not possess them; however, another of the NPT objectives is to encourage arms control efforts in the nuclear and nonnuclear arenas. Accordingly, under Article VI, each of the Parties to the Treaty undertakes to pursuemore » negotiations in good faith on effective measures relating to cessation of the nuclear arms race at an early date to nuclear disarmament, and on a treaty on general and complete disarmament under strict and effective international control.'' This paper discusses ideas put forward at the Review Conference.« less

  14. Summary of the Forty-Fifth NCRP annual meeting on "the future of nuclear power worldwide: safety, health and the environment".

    PubMed

    Corradini, Michael

    2011-01-01

    The role of nuclear power as a major resource in meeting the projected growth of electric power requirements in the United States and worldwide during the 21st century is a subject of great contemporary interest. The goal of the 2009 NCRP Annual Meeting was to provide a forum for an in-depth discussion of issues related to the safety, health and environmental protection aspects of new nuclear power reactor systems and related fuel-cycle facilities such as fuel production and reprocessing strategies. The meeting was an international conference with participation of almost 400 representatives from many nations, scientific organizations, nuclear industries, and governmental agencies engaged in the development and regulatory control of advanced nuclear reactor systems and fuel-cycle operations. Highlights of the meeting are summarized in this report. Copyright © 2010 Health Physics Society

  15. Calculation of energetic characteristics of C-14 emitted from Beloyarsk nuclear power plant plume with fast neutron reactor

    NASA Astrophysics Data System (ADS)

    Kolotkov, Gennady A.; Penin, Sergei

    2017-11-01

    The paper examines an update of comparative analysis of radionuclides released into the atmosphere from Beloyarsk nuclear power plant with fast-neutron reactor for nine years in a row, from 2008 to 2016. It has been shown that the main radionuclides throw out into the atmosphere from Beloyarsk nuclear power plant are beta-active radionuclides. Based on data releases of the RPA "Typhoon", it has been conclude that radiation situation become worse insignificantly; beside on the new reactor BN-800 was put in operation in 2016. Using Spencer-Fano's equation, it was carried out the summary spectrum of emitted radionuclides. On example of Beloyarsk nuclear power plant, it was considered a question about ability of remote detection of raised radioactivity in the atmospheric radioactive plume. It has been shown that it possible to detect raised radioactivity in the emission plume from Beloyarsk nuclear power plant.

  16. 78 FR 49784 - Pacific Gas and Electric Company, Humboldt Bay Power Plant, Unit 3, Notice of Public Meeting on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-15

    ...; correction. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is correcting a notice that was published...-0001, telephone: 301-287- 0949; email: [email protected] . Correction In the Federal Register (FR...

  17. Neural Differentiation in HDAC1-Depleted Cells Is Accompanied by Coilin Downregulation and the Accumulation of Cajal Bodies in Nucleoli.

    PubMed

    Krejčí, Jana; Legartová, Soňa; Bártová, Eva

    2017-01-01

    Cajal bodies (CBs) are important compartments containing accumulated proteins that preferentially regulate RNA-related nuclear events, including splicing. Here, we studied the nuclear distribution pattern of CBs in neurogenesis. In adult brains, coilin was present at a high density, but CB formation was absent in the nuclei of the choroid plexus of the lateral ventricles. Cells of the adult hippocampus were characterized by a crescent-like morphology of coilin protein. We additionally observed a 70 kDa splice variant of coilin in adult mouse brains, which was different to embryonic brains and mouse pluripotent embryonic stem cells (mESCs), characterized by the 80 kDa standard variant of coilin. Here, we also showed that depletion of coilin is induced during neural differentiation and HDAC1 deficiency in mESCs caused coilin accumulation inside the fibrillarin-positive region of the nucleoli. A similar distribution pattern was observed in adult brain hippocampi, characterized by lower levels of both coilin and HDAC1. In summary, we observed that neural differentiation and HDAC1 deficiency lead to coilin depletion and coilin accumulation in body-like structures inside the nucleoli.

  18. Summary of Planned Implementation for the HTGR Lessons Learned Applicable to the NGNP

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ian Mckirdy

    2011-09-01

    This document presents a reconciliation of the lessons learned during a 2010 comprehensive evaluation of pertinent lessons learned from past and present high temperature gas-cooled reactors that apply to the Next Generation Nuclear Plant Project along with current and planned activities. The data used are from the latest Idaho National Laboratory research and development plans, the conceptual design report from General Atomics, and the pebble bed reactor technology readiness study from AREVA. Only those lessons related to the structures, systems, and components of the Next Generation Nuclear Plant (NGNP), as documented in the recently updated lessons learned report are addressed.more » These reconciliations are ordered according to plant area, followed by the affected system, subsystem, or component; lesson learned; and finally an NGNP implementation statement. This report (1) provides cross references to the original lessons learned document, (2) describes the lesson learned, (3) provides the current NGNP implementation status with design data needs associated with the lesson learned, (4) identifies the research and development being performed related to the lesson learned, and (5) summarizes with a status of how the lesson learned has been addressed by the NGNP Project.« less

  19. Probabilistic accident consequence uncertainty analysis -- Uncertainty assessment for deposited material and external doses. Volume 2: Appendices

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goossens, L.H.J.; Kraan, B.C.P.; Cooke, R.M.

    1997-12-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library ofmore » uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA deposited material and external dose models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the panel on deposited material and external doses, (4) short biographies of the experts, and (5) the aggregated results of their responses.« less

  20. U.S. Department of Energy Office of Nuclear Technology Research and Eevelopment ((NTRD) comprehensive summary of QA assessments for FY17

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Trost, Alan L.

    The U.S. Department of Energy (DOE) Office of Nuclear Energy (NE) has developed a research and development (R&D) roadmap for its research, development, and demonstration (RD&D) activities to ensure nuclear energy remains a compelling and viable energy option for the U.S. The roadmap defines NE RD&D activities and objectives that address the challenges to research, develop and demonstrate options to the current U.S commercial fuel cycle to enable the safe, secure, economic, and sustainable expansion of nuclear energy, while minimizing proliferation and terrorism risks expanding the use of nuclear power. The roadmap enables the development of technologies and other solutionsmore » that can improve the reliability, sustain the safety, and extend the life of current reactors. In addition, it will help to develop improvements in the affordability of the new reactors to enable nuclear energy to help meet the Administration’s energy security and climate change goals.« less

  1. Summary Report for the Radiation Detection for Nuclear Security Summer School 2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Runkle, Robert C.; Baciak, James E.; Stave, Jean A.

    The Pacific Northwest National Laboratory (PNNL) hosted students from across the United States at the inaugural Radiation Detection for Nuclear Security Summer School from June 11 – 22, 2012. The summer school provided students with a unique understanding of nuclear security challenges faced in the field and exposed them to the technical foundations, analyses, and insight that will be required by future leaders in technology development and implementation. The course heavily emphasized laboratory and field demonstrations including direct measurements of special nuclear material. The first week of the summer school focused on the foundational knowledge required by technology practitioners; themore » second week focused on contemporary applications. Student evaluations and feedback from student advisors indicates that the summer school achieved its objectives of 1) exposing students to the range of nuclear security applications for which radiation detection is necessary, 2) articulating the relevance of student research into the broader context, and 3) exciting students about the possibility of future careers in nuclear security.« less

  2. Summary of the study of disposal of nuclear waste into space

    NASA Technical Reports Server (NTRS)

    Rom, F. E.

    1973-01-01

    NASA, at the request of the AEC, is conducting a preliminary study to determine the feasibility of disposing of nuclear waste material into space. The study has indicated that the Space Shuttle together with expendable and nonexpendable orbital stages such as the Space Tug or Centaur can safety dispose of waste material by ejecting it from the solar system. The safety problems associated with all phases of launching and operation (normal, emergency and accident) of such a system are being examined. From the preliminary study it appears that solutions can be found that should make the risks acceptable when compared to the benefits to be obtained from the disposal of the nuclear waste.

  3. Does perinatal asphyxia induce apoptosis in the inner ear?

    PubMed

    Schmutzhard, Joachim; Glueckert, Rudolf; Sergi, Consolato; Schwentner, Ilona; Abraham, Irene; Schrott-Fischer, Annelies

    2009-04-01

    Pre- and perinatal asphyxia is known to be an important risk factor in the development of neonatal hearing impairment. This study aims to evaluate the role of apoptosis, which is known to play an essential role in the development of the inner ear structures, in the development of neonatal hearing loss caused by pre- and perinatal asphyxia. Eight temporal bones of six different newborns were included. We performed a morphologic analysis by both light microscopy, and transmission electron microscopy, as well as immunohistochemical staining to detect the cleaved form of caspase 3 as apoptosis marker and Bcl 2 as anti-apoptotic marker. Early and late phases of apoptosis were evidenced by condensation of chromatin (electron-dense, black structure along nuclear membrane) and fragmentation of the nucleus, respectively. Changes in nuclear morphology during apoptosis correlate with cleavage by caspase 3 located downstream of Bcl 2 action. The immunohistochemistry for cleaved caspase 3 showed a particular predilection for the inner and outer hair cells, spiral ganglion cells and the marginal cells of the stria vascularis. The brain of all examined cases did not show signs of apoptosis. In summary, this investigation suggests that apoptosis takes place before brain tissue apoptosis and is probably an earlier event than thought. Apoptosis of the cochlea is known to play an essential role in the development of the inner ear. Additionally, this study shows that apoptosis may play an important role in the development of hearing impairment, caused by pre- and perinatal asphyxia.

  4. 78 FR 46621 - Status of the Office of New Reactors' Implementation of Electronic Distribution of Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... of Electronic Distribution of Advanced Reactor Correspondence AGENCY: Nuclear Regulatory Commission. ACTION: Implementation of electronic distribution of advanced reactor correspondence; issuance. SUMMARY... public that, in the future, publicly available correspondence originating from the Division of Advanced...

  5. Nuclear Reactor Safety--The APS Submits its Report

    ERIC Educational Resources Information Center

    Physics Today, 1975

    1975-01-01

    Presents the summary section of the American Physical Society (APS) report on the safety features of the light-water reactor, reviews the design, construction, and operation of a reactor and outlines the primary engineered safety features. Summarizes the major recommendations of the study group. (GS)

  6. 75 FR 32416 - Defense Science Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... DEPARTMENT OF DEFENSE Office of the Secretary Defense Science Board AGENCY: Department of Defense (DoD). ACTION: Notice of advisory committee meeting. SUMMARY: The Defense Science Board Task Force on the Survivability of DoD Systems and Assets to Electromagnetic Pulse (EMP) and other Nuclear Weapons...

  7. 75 FR 27768 - Office of International Regimes and Agreements; Proposed Subsequent Arrangement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... Article 6(iii) of the Agreement for Cooperation Concerning Peaceful Uses of Nuclear Energy (``the... DEPARTMENT OF ENERGY Office of International Regimes and Agreements; Proposed Subsequent Arrangement AGENCY: Department of Energy. ACTION: Subsequent arrangement. SUMMARY: This notice has been issued...

  8. California Alliance For Radiotracer Education, CARE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sutcliffe, Julie

    The report contains a summary of the accomplishments made during the CARE proposal. The overall goal of this proposal was to train graduate students and postdoctoral fellows in the field of radiochemistry. The goal was to expose trainees to the fundamentals of radioisotope production, radiochemistry synthesis, synthetic organic chemistry as well as applications and hands on experience in small animal imaging. In summary approximately 30 trainees were involved including trainees both at the graduate and postdoctoral levels. This funding has to date resulted in publications in high impact journals such as Med Chem Comm, Journal of Nuclear Medicine and Molecularmore » Imaging and Biology. Trainees have gone on to further their careers in both academia, industry and the private sector. The funding will result in seven Master’s and six Ph.D dissertations. Without the DOE funding it simply would not have been possible to continue to train the next generation of radiochemists needed to assure a future US-based Nuclear and Radiochemistry Expertise.« less

  9. Essentials and guidelines for clinical medical physics residency training programs: executive summary of AAPM Report Number 249.

    PubMed

    Prisciandaro, Joann I; Willis, Charles E; Burmeister, Jay W; Clarke, Geoffrey D; Das, Rupak K; Esthappan, Jacqueline; Gerbi, Bruce J; Harkness, Beth A; Patton, James A; Peck, Donald J; Pizzutiello, Robert J; Sandison, George A; White, Sharon L; Wichman, Brian D; Ibbott, Geoffrey S; Both, Stefan

    2014-05-08

    There is a clear need for established standards for medical physics residency training. The complexity of techniques in imaging, nuclear medicine, and radiation oncology continues to increase with each passing year. It is therefore imperative that training requirements and competencies are routinely reviewed and updated to reflect the changing environment in hospitals and clinics across the country. In 2010, the AAPM Work Group on Periodic Review of Medical Physics Residency Training was formed and charged with updating AAPM Report Number 90. This work group includes AAPM members with extensive experience in clinical, professional, and educational aspects of medical physics. The resulting report, AAPM Report Number 249, concentrates on the clinical and professional knowledge needed to function independently as a practicing medical physicist in the areas of radiation oncology, imaging, and nuclear medicine, and constitutes a revision to AAPM Report Number 90. This manuscript presents an executive summary of AAPM Report Number 249.

  10. Essentials and guidelines for clinical medical physics residency training programs: executive summary of AAPM Report Number 249

    PubMed Central

    Willis, Charles E.; Burmeister, Jay W.; Clarke, Geoffrey D.; Das, Rupak K.; Esthappan, Jacqueline; Gerbi, Bruce J.; Harkness, Beth A.; Patton, James A.; Peck, Donald J.; Pizzutiello, Robert J.; Sandison, George A.; White, Sharon L.; Wichman, Brian D.; Ibbott, Geoffrey S.; Both, Stefan

    2014-01-01

    There is a clear need for established standards for medical physics residency training. The complexity of techniques in imaging, nuclear medicine, and radiation oncology continues to increase with each passing year. It is therefore imperative that training requirements and competencies are routinely reviewed and updated to reflect the changing environment in hospitals and clinics across the country. In 2010, the AAPM Work Group on Periodic Review of Medical Physics Residency Training was formed and charged with updating AAPM Report Number 90. This work group includes AAPM members with extensive experience in clinical, professional, and educational aspects of medical physics. The resulting report, AAPM Report Number 249, concentrates on the clinical and professional knowledge needed to function independently as a practicing medical physicist in the areas of radiation oncology, imaging, and nuclear medicine, and constitutes a revision to AAPM Report Number 90. This manuscript presents an executive summary of AAPM Report Number 249. PACS number: 87.10.‐e PMID:24892354

  11. Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in Its Dissociation from Chromatin and the Nuclear Matrix.

    PubMed

    Kubota, Sho; Morii, Mariko; Yuki, Ryuzaburo; Yamaguchi, Noritaka; Yamaguchi, Hiromi; Aoyama, Kazumasa; Kuga, Takahisa; Tomonaga, Takeshi; Yamaguchi, Naoto

    2015-04-24

    Protein-tyrosine phosphorylation regulates a wide variety of cellular processes at the plasma membrane. Recently, we showed that nuclear tyrosine kinases induce global nuclear structure changes, which we called chromatin structural changes. However, the mechanisms are not fully understood. In this study we identify protein kinase A anchoring protein 8 (AKAP8/AKAP95), which associates with chromatin and the nuclear matrix, as a nuclear tyrosine-phosphorylated protein. Tyrosine phosphorylation of AKAP8 is induced by several tyrosine kinases, such as Src, Fyn, and c-Abl but not Syk. Nucleus-targeted Lyn and c-Src strongly dissociate AKAP8 from chromatin and the nuclear matrix in a kinase activity-dependent manner. The levels of tyrosine phosphorylation of AKAP8 are decreased by substitution of multiple tyrosine residues on AKAP8 into phenylalanine. Importantly, the phenylalanine mutations of AKAP8 inhibit its dissociation from nuclear structures, suggesting that the association/dissociation of AKAP8 with/from nuclear structures is regulated by its tyrosine phosphorylation. Furthermore, the phenylalanine mutations of AKAP8 suppress the levels of nuclear tyrosine kinase-induced chromatin structural changes. In contrast, AKAP8 knockdown increases the levels of chromatin structural changes. Intriguingly, stimulation with hydrogen peroxide induces chromatin structural changes accompanied by the dissociation of AKAP8 from nuclear structures. These results suggest that AKAP8 is involved in the regulation of chromatin structural changes through nuclear tyrosine phosphorylation. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. Nuclear EGFRvIII resists hypoxic microenvironment induced apoptosis via recruiting ERK1/2 nuclear translocation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xie, Hui; Yang, Jinfeng; Xing, Wenjing

    2016-02-05

    Glioblastoma (GBM) is the most aggressive type of primary brain tumor. Its interaction with the tumor microenvironment promotes tumor progression. Furthermore, GBM bearing expression of EGFRvIII displays more adaptation to tumor microenvironment related stress. But the mechanisms were poorly understood. Here, we presented evidence that in the human U87MG glioblastoma tumor model, EGFRvIII overexpression led aberrant kinase activation and nuclear translocation of EGFRvIII/ERK1/2 under hypoxia, which induced growth advantage by resisting apoptosis. Additionally, EGFRvIII defective in nuclear entry impaired this capacity in hypoxia adaptation, and partially interrupted ERK1/2 nuclear translocation. Pharmacology or genetic interference ERK1/2 decreased hypoxia resistance triggered bymore » EGFRvIII expression, but not EGFRvIII nuclear translocation. In summary, this study identified a novel role for EGFRvIII in hypoxia tolerance, supporting an important link between hypoxia and subcellular localization alterations of the receptor. - Highlights: • Nuclear translocation of EGFRvIII contributes to GBM cell apoptotic resistance by hypoxia. • Nuclear ERK1/2 facilitates EGFRvIII in hypoxia resistance. • EGFRvIII nuclear translocation is not dependent on ERK1/2.« less

  13. Nuclear thioredoxin-1 is required to suppress cisplatin-mediated apoptosis of MCF-7 cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, Xiao-Ping; Liu, Shou; Tang, Wen-Xin

    2007-09-21

    Different cell line with increased thioredoxin-1 (Trx-1) showed a decreased or increased sensitivity to cell killing by cisplatin. Recently, several studies found that the subcellular localization of Trx-1 is closely associated with its functions. In this study, we explored the association of the nuclear Trx-1 with the cisplatin-mediated apoptosis of breast cancer cells MCF-7. Firstly, we found that higher total Trx-1 accompanied by no change of nuclear Trx-1 can not influence apoptosis induced by cisplatin in MCF-7 cells transferred with Trx-1 cDNA. Secondly, higher nuclear Trx-1 accompanied by no change of total Trx-1 can protect cells from apoptosis induced bymore » cisplatin. Thirdly, high nuclear Trx-1 involves in the cisplatin-resistance in cisplatin-resistive cells. Meanwhile, we found that the mRNA level of p53 is closely correlated with the level of nuclear Trx-1. In summary, we concluded that the nuclear Trx-1 is required to resist apoptosis of MCF-7 cells induced by cisplatin, probably through up-regulating the anti-apoptotic gene, p53.« less

  14. Cancer Genetics Overview (PDQ®)—Health Professional Version

    Cancer.gov

    Expert-reviewed information summary in which the features of hereditary cancer and the structure and content of other PDQ cancer genetics summaries are described. The summary also contains an extensive list of genetics resources available online.

  15. Selective alterations of the host cell architecture upon infection with parvovirus minute virus of mice

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nueesch, Juerg P.F.; Lachmann, Sylvie; Rommelaere, Jean

    During a productive infection, the prototype strain of parvovirus minute virus of mice (MVMp) induces dramatic morphological alterations to the fibroblast host cell A9, resulting in cell lysis and progeny virus release. In order to understand the mechanisms underlying these changes, we characterized the fate of various cytoskeletal filaments and investigated the nuclear/cytoplasmic compartmentalization of infected cells. While most pronounced effects could be seen on micro- and intermediate filaments, manifest in dramatic rearrangements and degradation of filamentous (F-)actin and vimentin structures, only little impact could be seen on microtubules or the nuclear envelope during the entire monitored time of infection.more » To further analyze the disruption of the cytoskeletal structures, we investigated the viral impact on selective regulatory pathways. Thereby, we found a correlation between microtubule stability and MVM-induced phosphorylation of {alpha}/{beta} tubulin. In contrast, disassembly of actin filaments late in infection could be traced back to the disregulation of two F-actin associated proteins gelsolin and Wiscott-Aldrich Syndrome Protein (WASP). Thereby, an increase in the amount of gelsolin, an F-actin severing protein was observed during infection, accounting for the disruption of stress fibers upon infection. Concomitantly, the actin polymerization activity also diminished due to a loss of WASP, the activator protein of the actin polymerization machinery the Arp2/3 complex. No effects could be seen in amount and distribution of other F-actin regulatory factors such as cortactin, cofilin, and profilin. In summary, the selective attack of MVM towards distinct host cell cytoskeletal structures argues for a regulatory feature during infection, rather than a collapse of the host cell as a mere side effect of virus production.« less

  16. USP7 small-molecule inhibitors interfere with ubiquitin binding.

    PubMed

    Kategaya, Lorna; Di Lello, Paola; Rougé, Lionel; Pastor, Richard; Clark, Kevin R; Drummond, Jason; Kleinheinz, Tracy; Lin, Eva; Upton, John-Paul; Prakash, Sumit; Heideker, Johanna; McCleland, Mark; Ritorto, Maria Stella; Alessi, Dario R; Trost, Matthias; Bainbridge, Travis W; Kwok, Michael C M; Ma, Taylur P; Stiffler, Zachary; Brasher, Bradley; Tang, Yinyan; Jaishankar, Priyadarshini; Hearn, Brian R; Renslo, Adam R; Arkin, Michelle R; Cohen, Frederick; Yu, Kebing; Peale, Frank; Gnad, Florian; Chang, Matthew T; Klijn, Christiaan; Blackwood, Elizabeth; Martin, Scott E; Forrest, William F; Ernst, James A; Ndubaku, Chudi; Wang, Xiaojing; Beresini, Maureen H; Tsui, Vickie; Schwerdtfeger, Carsten; Blake, Robert A; Murray, Jeremy; Maurer, Till; Wertz, Ingrid E

    2017-10-26

    The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is ligated to substrate proteins as monomers or chains and the topology of ubiquitin modifications regulates substrate interactions with specific proteins. Thus ubiquitination directs a variety of substrate fates including proteasomal degradation. Deubiquitinase enzymes cleave ubiquitin from substrates and are implicated in disease; for example, ubiquitin-specific protease-7 (USP7) regulates stability of the p53 tumour suppressor and other proteins critical for tumour cell survival. However, developing selective deubiquitinase inhibitors has been challenging and no co-crystal structures have been solved with small-molecule inhibitors. Here, using nuclear magnetic resonance-based screening and structure-based design, we describe the development of selective USP7 inhibitors GNE-6640 and GNE-6776. These compounds induce tumour cell death and enhance cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors. Structural studies reveal that GNE-6640 and GNE-6776 non-covalently target USP7 12 Å distant from the catalytic cysteine. The compounds attenuate ubiquitin binding and thus inhibit USP7 deubiquitinase activity. GNE-6640 and GNE-6776 interact with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain, suggesting that USP7 preferentially interacts with and cleaves ubiquitin moieties that have free Lys48 side chains. We investigated this idea by engineering di-ubiquitin chains containing differential proximal and distal isotopic labels and measuring USP7 binding by nuclear magnetic resonance. This preferential binding protracted the depolymerization kinetics of Lys48-linked ubiquitin chains relative to Lys63-linked chains. In summary, engineering compounds that inhibit USP7 activity by attenuating ubiquitin binding suggests opportunities for developing other deubiquitinase inhibitors and may be a strategy more broadly applicable to inhibiting proteins that require ubiquitin binding for full functional activity.

  17. FY13 Summary Report on the Augmentation of the Spent Fuel Composition Dataset for Nuclear Forensics: SFCOMPO/NF

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brady Raap, Michaele C.; Lyons, Jennifer A.; Collins, Brian A.

    This report documents the FY13 efforts to enhance a dataset of spent nuclear fuel isotopic composition data for use in developing intrinsic signatures for nuclear forensics. A review and collection of data from the open literature was performed in FY10. In FY11, the Spent Fuel COMPOsition (SFCOMPO) excel-based dataset for nuclear forensics (NF), SFCOMPO/NF was established and measured data for graphite production reactors, Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs) were added to the dataset and expanded to include a consistent set of data simulated by calculations. A test was performed to determine whether the SFCOMPO/NF dataset willmore » be useful for the analysis and identification of reactor types from isotopic ratios observed in interdicted samples.« less

  18. Health care reform: a short summary.

    PubMed

    Harolds, Jay

    2010-09-01

    The Health Care Reform legislation has many provisions of importance to the nuclear medicine community. This article is not a complete summary of the thousands of pages in the legislation, but emphasizes some relevant aspects of the bills. When the plan is fully implemented, about 32 million more Americans will have health insurance. Pre-existing medical conditions will no longer result in insurance denials. There are many initiatives to slow the growth of spending on health care in various ways, such as by setting up the new Medicare Advisory Board. There are also new fees, taxes, penalties, subsidies, and tax deduction changes.

  19. OAST Space Theme Workshop. Volume 2: Theme summary. 4: Solar system exploration (no. 10). A: Statement of theme: B. 26 April 1976 Presentation. C. Summary. D. Initiative actions (form 5)

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Major strategies for exploring the solar system focus on the return of information and the return of matter. Both the planetary exploration facility, and an orbiting automated space station, and the sample return and exploration facility have similar requirements. The single most essential need to enable intensive study of the outer solar system is nuclear propulsion and power capability. New initiatives in 1978 related to the reactor, data and sample acquisition and return, navigation, and environmental protection are examined.

  20. Advanced Nuclear Technology: Advanced Light Water Reactors Utility Requirements Document Small Modular Reactors Inclusion Summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Loflin, Leonard; McRimmon, Beth

    2014-12-18

    This report summarizes a project by EPRI to include requirements for small modular light water reactors (smLWR) into the EPRI Utility Requirements Document (URD) for Advanced Light Water Reactors. The project was jointly funded by EPRI and the U.S. Department of Energy (DOE). The report covers the scope and content of the URD, the process used to revise the URD to include smLWR requirements, a summary of the major changes to the URD to include smLWR, and how to use the URD as revised to achieve value on new plant projects.

  1. Francis bitter national magnet laboratory annual report, July 1991 through June 1992

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-06-01

    ;Contents: Reports on Laboratory Research Programs--Magneto-Optics and Semiconductor Physics, Superconductivity and Magnetism, Solid State Nuclear Magnetic Resonance, Condensed Matter Chemistry, Biomagnetism, Magnet Technology, Instrumentation, Molecular Biophysics, Carbon Filters and Fullerenes; Reports of Visiting Scientists--Reports of Users of the High Magnetic Field Facility, Reports of the Users of the Pulsed Field Facility, Reports of the Users of the High Field NMR Facility; Appendices--Publications and Meeting Speeches, Organization, Summary of High Magnetic Field Facility Use--January 1, 1984 through June 30, 1992, Geographic Distribution of High Magnetic Field Facility Users (Excluding FBNML Staff), Summary of Educational Activities.

  2. Francis Bitter National Magnet Laboratory annual report, July 1990 through June 1991

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1991-06-01

    The contents include: reports on laboratory research programs--magneto-optics and semiconductor physics, magnetism, superconductivity, solid state nuclear magnetic resonance, condensed matter chemistry, biomagnetism, magnet technology, instrumentation, molecular biophysics; reports of visiting scientists--reports of users of the high magnetic field facility, reports of users of the pulsed field facility, reports of users of the SQUID magnetometer and Mossbauer facility, reports of users of the high field NMR facility; appendices--publications and meeting speeches, organization, summary of high magnetic field facility use, user tables, geographic distribution of high magnetic field facility users, summary of educational activities.

  3. Francis Bitter National Magnet Laboratory annual report, July 1989 through June 1990

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1990-01-01

    Contents: Reports on laboratory research programs: Magneto-optics and semiconductor physics, Magnetism, Superconductivity, Solid state nuclear magnetic resonance, Condensed matter chemistry, Biomagnetism, Magnet technology, Molecular biophysics; Reports of visiting scientists: Reports of users of the High Magnetic Field Facility, Reports of users of the pulsed field facility, Reports of users of the squid magnetometer and Mossbauer facility, Reports of users of the high field NMR facility; Appendices: Publications and meeting speeches, Organization, Summary of high magnetic field facility use, User tables, Geographic distribution of high magnetic field facility users, Summary of educational activities.

  4. OAST Space Theme Workshop. Volume 2: Theme summary. 1: Space power (no. 7). A. Theme statement. B. 26 April 1976 presentation. C. Summary. D. Initiative action

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A long-lived space-based system that converts on-orbit solar and/or nuclear energy to a suitable form for distribution to using space systems is described. Mission applications, requirements, issues, problems, benefits, and technology thrusts are identified for the multipurpose power platform. Power levels of at least 10-100Kw are required for space manufacturing, satellites, and space station operations. Two Mw are needed for a proposed passive radar system. Propulsion system requirements are in the 100Kw-100Mw range.

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Evelo, Stacie

    This report provides a summary of the radionuclide releases from the United States (U.S.) Department of Energy (DOE) National Nuclear Security Administration facilities at Sandia National Laboratories, New Mexico (SNL/NM) during Calendar Year (CY) 2015, including the data, calculations, and supporting documentation for demonstrating compliance with 40 Code of Federal Regulation (CFR) 61.

  6. 76 FR 75566 - Appointments to Performance Review Boards for Senior Executive Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... NUCLEAR REGULATORY COMMISSION [NRC-2011-0249] Appointments to Performance Review Boards for Senior... for Senior Executive Service. SUMMARY: This notice announces a change in the membership of the Senior... appointing and awarding authorities on performance appraisal ratings and performance awards for Senior...

  7. 77 FR 37717 - Electrical Cable Test Results and Analysis During Fire Exposure

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... Fire Exposure AGENCY: Nuclear Regulatory Commission. ACTION: Draft NUREG; request for comment. SUMMARY...-2128, ``Electrical Cable Test Results and Analysis during Fire Exposure (ELECTRA-FIRE), A Consolidation of the Three Major Fire-Induced Circuit and Cable Failure Experiments Performed between 2001 and 2011...

  8. Ballistic missile defense technologies

    NASA Astrophysics Data System (ADS)

    1985-09-01

    A report on Ballistic Missile Technologies includes the following: Executive summary; Introduction; Ballistic missiles then and now; Deterrence, U.S. nuclear strategy, and BMD; BMD capabilities and the strategic balance; Crisis stability, arms race stability, and arms control issues; Ballistic missile defense technologies; Feasibility; Alternative future scenarios; Alternative R&D programs.

  9. Performance-based quality assurance/quality control (QA/QC) acceptance procedures for in-place soil testing phase 3 : [summary].

    DOT National Transportation Integrated Search

    2015-01-01

    Acceptance of earthwork construction by the Florida Department of Transportation (FDOT) : requires in-place testing conducted with a nuclear density gauge (NDG) to determine : dry density, which must obtain a required percent compaction based upon a ...

  10. A brief history of Lord Rutherford's radium

    PubMed Central

    Todd, Neil

    2014-01-01

    In this paper I give a brief summary of what is known about the acquisition, use and fate of the radium sources that were in the possession of Lord Rutherford during his lifetime. The account is written in two parts, corresponding to the periods from the discovery of radium in 1898 until his death in 1937 and then from 1937 until recent times. The history of Rutherford's radium closely shadows the history of radioactivity, the evolution of nuclear physics, the race for the bomb, and the development of the nuclear industry. PMID:25254280

  11. Seismic margin assessment of the Edwin I. Hatch Nuclear Plant, Unit 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barr, W.T.; Moore, D.P.; Smith, J.E.

    1991-06-01

    This summary presents the results and lessons learned from the seismic margin assessment (SMA) of Unit 1 of the Hatch Nuclear Plant. The primary purpose of this SMA was to assess the practicality of the EPRI SMA methodology on a BWR on a soil site such as Hatch. The major findings from the Hatch SMA are briefly described along with the lessons learned during the project implementation. The experience gained on the Hatch SMA is expected to benefit others in the performance of future SMAs. 12 refs.

  12. Inorganic chemistry in nuclear imaging and radiotherapy: current and future directions

    PubMed Central

    Carroll, Valerie; Demoin, Dustin W.; Hoffman, Timothy J; Jurisson, Silvia S

    2013-01-01

    Summary Radiometals play an important role in diagnostic and therapeutic radiopharmaceuticals. This field of radiochemistry is multidisciplinary, involving radiometal production, separation of the radiometal from its target, chelate design for complexing the radiometal in a biologically stable environment, specific targeting of the radiometal to its in vivo site, and nuclear imaging and/or radiotherapy applications of the resultant radiopharmaceutical. The critical importance of inorganic chemistry in the design and application of radiometal-containing imaging and therapy agents is described from a historical perspective to future directions. PMID:25382874

  13. Simulations to Evaluate Accuracy and Patient Dose in Neutron-Stimulated, Emission-Computed Tomography (NSECT) for Diagnosis of Breast Cancer

    DTIC Science & Technology

    2009-04-01

    table 1 and includes all of the excited state transitions that are included in the BNL database. In this study we considered only states that could be...16Cross Section Evaluation Working Group, ENDEIB-VI Summary Docu- mentation, Report BNL -NCS-17541 ENDF-201, edited by P. F. Rose, National Nuclear Data...Med. Phys., vol. 34, pp. 3866–3871, 2007. [37] National Nuclear Data Center BNL , NuDat 2.3 2007. [38] A. J. Kapadia and C. E. Floyd, “An attenuation

  14. Proceedings of the Nuclear Criticality Technology Safety Workshop

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rene G. Sanchez

    1998-04-01

    This document contains summaries of most of the papers presented at the 1995 Nuclear Criticality Technology Safety Project (NCTSP) meeting, which was held May 16 and 17 at San Diego, Ca. The meeting was broken up into seven sessions, which covered the following topics: (1) Criticality Safety of Project Sapphire; (2) Relevant Experiments For Criticality Safety; (3) Interactions with the Former Soviet Union; (4) Misapplications and Limitations of Monte Carlo Methods Directed Toward Criticality Safety Analyses; (5) Monte Carlo Vulnerabilities of Execution and Interpretation; (6) Monte Carlo Vulnerabilities of Representation; and (7) Benchmark Comparisons.

  15. The 4D Nucleome: Genome Compartmentalization in an Evolutionary Context.

    PubMed

    Cremer, T; Cremer, M; Cremer, C

    2018-04-01

    4D nucleome research aims to understand the impact of nuclear organization in space and time on nuclear functions, such as gene expression patterns, chromatin replication, and the maintenance of genome integrity. In this review we describe evidence that the origin of 4D genome compartmentalization can be traced back to the prokaryotic world. In cell nuclei of animals and plants chromosomes occupy distinct territories, built up from ~1 Mb chromatin domains, which in turn are composed of smaller chromatin subdomains and also form larger chromatin domain clusters. Microscopic evidence for this higher order chromatin landscape was strengthened by chromosome conformation capture studies, in particular Hi-C. This approach demonstrated ~1 Mb sized, topologically associating domains in mammalian cell nuclei separated by boundaries. Mutations, which destroy boundaries, can result in developmental disorders and cancer. Nucleosomes appeared first as tetramers in the Archaea kingdom and later evolved to octamers built up each from two H2A, two H2B, two H3, and two H4 proteins. Notably, nucleosomes were lost during the evolution of the Dinoflagellata phylum. Dinoflagellate chromosomes remain condensed during the entire cell cycle, but their chromosome architecture differs radically from the architecture of other eukaryotes. In summary, the conservation of fundamental features of higher order chromatin arrangements throughout the evolution of metazoan animals suggests the existence of conserved, but still unknown mechanism(s) controlling this architecture. Notwithstanding this conservation, a comparison of metazoans and protists also demonstrates species-specific structural and functional features of nuclear organization.

  16. Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution

    PubMed Central

    Lambowitz, Alan M.; Belfort, Marlene

    2015-01-01

    SUMMARY This review focuses on recent developments in our understanding of group II intron function, the relationships of these introns to retrotransposons and spliceosomes, and how their common features have informed thinking about bacterial group II introns as key elements in eukaryotic evolution. Reverse transcriptase-mediated and host factor-aided intron retrohoming pathways are considered along with retrotransposition mechanisms to novel sites in bacteria, where group II introns are thought to have originated. DNA target recognition and movement by target-primed reverse transcription infer an evolutionary relationship among group II introns, non-LTR retrotransposons, such as LINE elements, and telomerase. Additionally, group II introns are almost certainly the progenitors of spliceosomal introns. Their profound similarities include splicing chemistry extending to RNA catalysis, reaction stereochemistry, and the position of two divalent metals that perform catalysis at the RNA active site. There are also sequence and structural similarities between group II introns and the spliceosome’s small nuclear RNAs (snRNAs) and between a highly conserved core spliceosomal protein Prp8 and a group II intron-like reverse transcriptase. It has been proposed that group II introns entered eukaryotes during bacterial endosymbiosis or bacterial-archaeal fusion, proliferated within the nuclear genome, necessitating evolution of the nuclear envelope, and fragmented giving rise to spliceosomal introns. Thus, these bacterial self-splicing mobile elements have fundamentally impacted the composition of extant eukaryotic genomes, including the human genome, most of which is derived from close relatives of mobile group II introns. PMID:25878921

  17. Property Data Summaries for Advanced Materials

    National Institute of Standards and Technology Data Gateway

    SRD 150 NIST Property Data Summaries for Advanced Materials (Web, free access)   Property Data Summaries are topical collections of property values derived from surveys of published data. Thermal, mechanical, structural, and chemical properties are included in the collections.

  18. Key Response Planning Factors for the Aftermath of Nuclear Terrorism

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Buddemeier, B R; Dillon, M B

    Despite hundreds of above-ground nuclear tests and data gathered from Hiroshima and Nagasaki, the effects of a ground-level, low-yield nuclear detonation in a modern urban environment are still the subject of considerable scientific debate. Extensive review of nuclear weapon effects studies and discussions with nuclear weapon effects experts from various federal agencies, national laboratories, and technical organizations have identified key issues and bounded some of the unknowns required to support response planning for a low-yield, ground-level nuclear detonation in a modern U.S. city. This study, which is focused primarily upon the hazards posed by radioactive fallout, used detailed fallout predictionsmore » from the advanced suite of three-dimensional (3-D) meteorology and plume/fallout models developed at Lawrence Livermore National Laboratory (LLNL), including extensive global Key Response Planning Factors for the Aftermath of Nuclear Terrorism geographical and real-time meteorological databases to support model calculations. This 3-D modeling system provides detailed simulations that account for complex meteorology and terrain effects. The results of initial modeling and analysis were presented to federal, state, and local working groups to obtain critical, broad-based review and feedback on strategy and messaging. This effort involved a diverse set of communities, including New York City, National Capitol Regions, Charlotte, Houston, Portland, and Los Angeles. The largest potential for reducing casualties during the post-detonation response phase comes from reducing exposure to fallout radiation. This can be accomplished through early, adequate sheltering followed by informed, delayed evacuation.B The response challenges to a nuclear detonation must be solved through multiple approaches of public education, planning, and rapid response actions. Because the successful response will require extensive coordination of a large number of organizations, supplemented by appropriate responses by local responders and the general population within the hazard zones, regional planning is essential to success. The remainder of this Executive Summary provides summary guidance for response planning in three areas: (1) Public Protection Strategy details the importance of early, adequate shelter followed by informed evacuation. (2) Responder Priorities identify how to protect response personnel, perform regional situational assessment, and support public safety. (3) Key Planning Considerations refute common myths and provide important information on planning how to respond in the aftermath of nuclear terrorism.« less

  19. Belief Structures of Students For and Against the Nuclear Freeze.

    ERIC Educational Resources Information Center

    Tankard, James W., Jr.

    An investigation of college students' belief structures underlying their support or non-support of a nuclear freeze revealed a three-dimensional structure for beliefs in the areas of nuclear weapons and national defense. A questionnaire containing 25 belief statements concerning national defense and nuclear weapons and 4 media use questions was…

  20. Nuclear Data Sheets page at the NNDC

    Science.gov Websites

    Data Sheets is a journal primarily devoted to the publication of evaluated nuclear structure and decay ; neutron, proton, alpha, cluster and cluster emission; fission. Nuclear structure and decay data are basis. The ENSDF database is the source for the nuclear structure and decay articles, which deal with a

  1. Structural Switch of Lysyl-tRNA Synthetase Between Translation and Transcription

    PubMed Central

    Ofir-Birin, Yifat; Fang, Pengfei; Bennett, Steven P.; Zhang, Hui-Min; Wang, Jing; Rachmin, Inbal; Shapiro, Ryan; Song, Jing; Dagan, Arie; Pozo, Jorge; Kim, Sunghoon; Marshall, Alan G.; Schimmel, Paul; Yang, Xiang-Lei; Nechushtan, Hovav; Razin, Ehud; Guo, Min

    2013-01-01

    SUMMARY Lysyl-tRNA synthetase (LysRS), a component of the translation apparatus, is released from the cytoplasmic multi-tRNA synthetase complex (MSC) to activate the transcription factor MITF in stimulated mast cells through undefined mechanisms. Here we show that Ser207-phosphorylation provokes a new conformer of LysRS that inactivates its translational, but activates its transcriptional function. The crystal structure of an MSC sub-complex established that LysRS is held in the MSC by binding to the N-terminus of the scaffold protein p38/AIMP2. Phosphorylation-created steric clashes at the LysRS domain interface disrupt its binding grooves for p38/AIMP2, releasing LysRS and provoking its nuclear translocation. This alteration also exposes the C-terminal domain of LysRS to bind to MITF and triggers LysRS-directed production of the second messenger Ap4A that activates MITF. Thus our results establish that a single conformational change triggered by phosphorylation leads to multiple effects driving an exclusive switch of LysRS function from translation to transcription. PMID:23159739

  2. Initial Assessment of Environmental Barrier Coatings for the Prometheus Project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    M. Frederick

    2005-12-15

    Depending upon final design and materials selections, a variety of engineering solutions may need to be considered to avoid chemical degradation of components in a notional space nuclear power plant (SNPP). Coatings are one engineered approach that was considered. A comprehensive review of protective coating technology for various space-reactor structural materials is presented, including refractory metal alloys [molybdenum (Mo), tungsten (W), rhenium (Re), tantalum (Ta), and niobium (Nb)], nickel (Ni)-base superalloys, and silicon carbide (Sic). A summary description of some common deposition techniques is included. A literature survey identified coatings based on silicides or iridium/rhenium as the primary methods formore » environmental protection of refractory metal alloys. Modified aluminide coatings have been identified for superalloys and multilayer ceramic coatings for protection of Sic. All reviewed research focused on protecting structural materials from extreme temperatures in highly oxidizing conditions. Thermodynamic analyses indicate that some of these coatings may not be protective in the high-temperature, impure-He environment expected in a Prometheus reactor system. Further research is proposed to determine extensibility of these coating materials to less-oxidizing or neutral environments.« less

  3. Gluons and the quark sea at high energies: distributions, polarization, tomography

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boer, D.; Venugopalan, R.; Diehl, M.

    2011-09-30

    This report is based on a ten-week program on Gluons and the quark sea at high-energies, which took place at the Institute for Nuclear Theory (INT) in Seattle in Fall 2010. The principal aim of the program was to develop and sharpen the science case for an Electron-Ion Collider (EIC), a facility that will be able to collide electrons and positrons with polarized protons and with light to heavy nuclei at high energies, offering unprecedented possibilities for in-depth studies of quantum chromodynamics (QCD). This report is organized around the following four major themes: (i) the spin and flavor structure ofmore » the proton, (ii) three dimensional structure of nucleons and nuclei in momentum and configuration space, (iii) QCD matter in nuclei, and (iv) Electroweak physics and the search for physics beyond the Standard Model. Beginning with an executive summary, the report contains tables of key measurements, chapter overviews for each of the major scientific themes, and detailed individual contributions on various aspects of the scientific opportunities presented by an EIC.« less

  4. 76 FR 78173 - Options for Developing the Regulatory Basis for Streamlining Non-Power Reactor License Renewal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... Emergency Preparedness AGENCY: Nuclear Regulatory Commission. ACTION: Notice of public meeting. SUMMARY: The... non-power reactor license renewal and non-power reactor emergency preparedness. This meeting is a... potential enhancements to emergency preparedness requirements. This meeting is open to the public. DATES...

  5. Hadrons registration in emulsion chamber with carbon block

    NASA Technical Reports Server (NTRS)

    Tomaszewski, A.; Wlodarczyk, Z.

    1985-01-01

    Nuclear-electro-magnetic cascade (NEC) in X-ray emulsion chambers with carbon block, which are usually used in the Pamir experiment, was Monte-Carlo simulated. Going over from optical density to Summary E sub gamma is discussed. The hole of NEC in the interpretation of energy spectra is analyzed.

  6. Spaceborne power systems preference analyses. Volume 1: Summary

    NASA Technical Reports Server (NTRS)

    Smith, J. H.; Feinberg, A.; Miles, R. F., Jr.

    1985-01-01

    Sixteen alternative spaceborne nuclear power system concepts were ranked using multiattribute decision analysis to identify promising concepts for further technology development. Four groups interviewed were: safety, systems definition and design, technology assessment, and mission analysis. The ranking results were consistent from group and for different utility function models for individuals.

  7. Training in Radiological Protection: Curricula and Programming.

    ERIC Educational Resources Information Center

    International Atomic Energy Agency, Vienna (Austria).

    A summary of training programs relating to radiation health and safety is presented in this report. Training courses are primarily categorized into five types, respectively, for specialists, personnel whose work is closely related to radiation, radiation users, nuclear installation staff, and the general public. To meet the present world needs,…

  8. 78 FR 40479 - Declaration That Circumstances Exist Justifying Authorization of Emergency Use of All Oral...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    .... ACTION: Notice. SUMMARY: The Secretary of Homeland Security determined on September 23, 2008, that there... specified biological, chemical, radiological, or nuclear agent or agents--in this case, Bacillus anthracis...). SUPPLEMENTARY INFORMATION: I. Background On September 23, 2008, former Secretary of Homeland Security, [[Page...

  9. 77 FR 40060 - Renewal of Declaration Regarding Emergency Use of All Oral Formulations of Doxycycline...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    .... ACTION: Notice. SUMMARY: The Secretary of Homeland Security determined on September 23, 2008 that there... specified biological, chemical, radiological, or nuclear agent or agents--in this case, Bacillus anthracis... free number). SUPPLEMENTARY INFORMATION: On September 23, 2008, former Secretary of Homeland Security...

  10. 77 FR 39708 - Renewal of Declaration Regarding Emergency Use of All Oral Formulations of Doxycycline...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    .... ACTION: Notice. SUMMARY: The Secretary of Homeland Security determined on September 23, 2008 that there... specified biological, chemical, radiological, or nuclear agent or agents--in this case, Bacillus anthracis... free number). SUPPLEMENTARY INFORMATION: On September 23, 2008, former Secretary of Homeland Security...

  11. 77 FR 39385 - Receipts-Based, Small Business Size Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... Business Size Standard AGENCY: Nuclear Regulatory Commission. ACTION: Direct final rule. SUMMARY: The U.S.... The NRC is increasing its receipts-based, small business size standard from $6.5 million to $7 million to conform to the standard set by the Small Business Administration (SBA). This size standard...

  12. U.S. Strategic Nuclear Forces: Background, Developments, and Issues

    DTIC Science & Technology

    2017-02-10

    This program area is specifically seeking to support the solid rocket motor research and development industrial base , so that it will have the...... Research Service Summary Even though the United States is in the process of reducing the number of warheads deployed on its long-range missiles and

  13. A review of ventilated storage cask (VSC) system projects and experience

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McConaghy, W.

    1995-12-31

    First, the author discusses the ventilated storage cask (VSC) design and an operations summary is given. Next VSC project status at Palisades, Point Beach, Arkansas Nuclear One, Fast Flux Test Facility and Zaporozhye is discussed. Lastly, VSC operational experience and VSC transportation interfaces are reviewed.

  14. 77 FR 55230 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-01; Compliance With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0068] Japan Lessons-Learned Project Directorate Interim... Commission (NRC). ACTION: Japan Lessons-Learned Project Directorate interim staff guidance; issuance. SUMMARY...-Learned Project Directorate Interim Staff Guidance (JLD-ISG), JLD-ISG-2012-01, ``Compliance with Order EA...

  15. WORKSHOP REPORT: MOLECULAR & CELLULAR BIOLOGY OF MODERATE DOSE (1-10 GY) RADIATION & POTENTIAL MECHANISMS OF RADIATION PROTECTION

    EPA Science Inventory

    EXECUTIVE SUMMARY

    Normal tissue response and injury after exposure to ionizing radiation are of great importance to patients with cancer, populations potentially subjected to military, accidental or intentional exposure including bioterrorism, and workers in the nuclear po...

  16. 76 FR 26651 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... Department of State's plan is designed to create a defined mechanism for identifying certain significant... Already Underway Independent of E.O. 13563 a. Summary of Pre-Existing Agency Efforts (Independent of E.O...--Spacecraft Systems and Associated Equipment [cir] Category XVI--Nuclear Weapons, Design and Testing Related...

  17. 77 FR 11171 - License Renewal Application for Callaway Plant, Unit 1, Union Electric Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... Callaway Plant, Unit 1, Union Electric Company AGENCY: Nuclear Regulatory Commission. ACTION: Intent to prepare environmental impact statement and conduct scoping process. SUMMARY: Union Electric Company, a..., MO. The current operating license for Callaway expires on October 18, 2024. DATES: The public scoping...

  18. Adapt-Mix: learning local genetic correlation structure improves summary statistics-based analyses

    PubMed Central

    Park, Danny S.; Brown, Brielin; Eng, Celeste; Huntsman, Scott; Hu, Donglei; Torgerson, Dara G.; Burchard, Esteban G.; Zaitlen, Noah

    2015-01-01

    Motivation: Approaches to identifying new risk loci, training risk prediction models, imputing untyped variants and fine-mapping causal variants from summary statistics of genome-wide association studies are playing an increasingly important role in the human genetics community. Current summary statistics-based methods rely on global ‘best guess’ reference panels to model the genetic correlation structure of the dataset being studied. This approach, especially in admixed populations, has the potential to produce misleading results, ignores variation in local structure and is not feasible when appropriate reference panels are missing or small. Here, we develop a method, Adapt-Mix, that combines information across all available reference panels to produce estimates of local genetic correlation structure for summary statistics-based methods in arbitrary populations. Results: We applied Adapt-Mix to estimate the genetic correlation structure of both admixed and non-admixed individuals using simulated and real data. We evaluated our method by measuring the performance of two summary statistics-based methods: imputation and joint-testing. When using our method as opposed to the current standard of ‘best guess’ reference panels, we observed a 28% decrease in mean-squared error for imputation and a 73.7% decrease in mean-squared error for joint-testing. Availability and implementation: Our method is publicly available in a software package called ADAPT-Mix available at https://github.com/dpark27/adapt_mix. Contact: noah.zaitlen@ucsf.edu PMID:26072481

  19. Semantic-Web Architecture for Electronic Discharge Summary Based on OWL 2.0 Standard.

    PubMed

    Tahmasebian, Shahram; Langarizadeh, Mostafa; Ghazisaeidi, Marjan; Safdari, Reza

    2016-06-01

    Patients' electronic medical record contains all information related to treatment processes during hospitalization. One of the most important documents in this record is the record summary. In this document, summary of the whole treatment process is presented which is used for subsequent treatments and other issues pertaining to the treatment. Using suitable architecture for this document, apart from the aforementioned points we can use it in other fields such as data mining or decision making based on the cases. In this study, at first, a model for patient's medical record summary has been suggested using semantic web-based architecture. Then, based on service-oriented architecture and using Java programming language, a software solution was designed and run in a way to generate medical record summary with this structure and at the end, new uses of this structure was explained. in this study a structure for medical record summaries along with corrective points within semantic web has been offered and a software running within Java along with special ontologies are provided. After discussing the project with the experts of medical/health data management and medical informatics as well as clinical experts, it became clear that suggested design for medical record summary apart from covering many issues currently faced in the medical records has also many advantages including its uses in research projects, decision making based on the cases etc.

  20. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Duggan, Ruth A

    In preparation for the 2005 US/Russian Weapons Laboratories Directors Meeting, the six laboratories participating in the meeting endeavored to develop a strategy for nonproliferation technology research and development. A literature review was conducted to identify possible areas of technical collaboration and technology opportunities associated with improving nonproliferation associated with the civilian nuclear fuel cycle. The issue of multinationalization of the nuclear fuel cycle was also researched. This digest is the compilation of one-page summaries used by management of the three US nuclear weapons laboratories in preparation for strategy development. Where possible, the Web site address of the complete paper ismore » referenced.3 AcknowledgementsThe author wishes to thank Jessica Ruyle, Nancy Orlando-Gay, and Barbara Dry for their research assistance and contributions.4« less

  1. Nuclear and particle physics, astrophysics and cosmology (NPAC) capability review

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Redondo, Antonio

    2010-01-01

    The present document represents a summary self-assessment of the status of the Nuclear and Particle Physics, Astrophysics and Cosmology (NPAC) capability across Los Alamos National Laboratory (LANL). For the purpose of this review, we have divided the capability into four theme areas: Nuclear Physics, Particle Physics, Astrophysics and Cosmology, and Applied Physics. For each theme area we have given a general but brief description of the activities under the area, a list of the Laboratory divisions involved in the work, connections to the goals and mission of the Laboratory, a brief description of progress over the last three years, ourmore » opinion of the overall status of the theme area, and challenges and issues.« less

  2. Summary and recommendations on nuclear electric propulsion technology for the space exploration initiative

    NASA Technical Reports Server (NTRS)

    Doherty, Michael P.; Holcomb, Robert S.

    1993-01-01

    A project in Nuclear Electric Propulsion (NEP) technology is being established to develop the NEP technologies needed for advanced propulsion systems. A paced approach has been suggested which calls for progressive development of NEP component and subsystem level technologies. This approach will lead to major facility testing to achieve TRL-5 for megawatt NEP for SEI mission applications. This approach is designed to validate NEP power and propulsion technologies from kilowatt class to megawatt class ratings. Such a paced approach would have the benefit of achieving the development, testing, and flight of NEP systems in an evolutionary manner. This approach may also have the additional benefit of synergistic application with SEI extraterrestrial surface nuclear power applications.

  3. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sublet, J.-Ch., E-mail: jean-christophe.sublet@ukaea.uk; Eastwood, J.W.; Morgan, J.G.

    Fispact-II is a code system and library database for modelling activation-transmutation processes, depletion-burn-up, time dependent inventory and radiation damage source terms caused by nuclear reactions and decays. The Fispact-II code, written in object-style Fortran, follows the evolution of material irradiated by neutrons, alphas, gammas, protons, or deuterons, and provides a wide range of derived radiological output quantities to satisfy most needs for nuclear applications. It can be used with any ENDF-compliant group library data for nuclear reactions, particle-induced and spontaneous fission yields, and radioactive decay (including but not limited to TENDL-2015, ENDF/B-VII.1, JEFF-3.2, JENDL-4.0u, CENDL-3.1 processed into fine-group-structure files, GEFY-5.2more » and UKDD-16), as well as resolved and unresolved resonance range probability tables for self-shielding corrections and updated radiological hazard indices. The code has many novel features including: extension of the energy range up to 1 GeV; additional neutron physics including self-shielding effects, temperature dependence, thin and thick target yields; pathway analysis; and sensitivity and uncertainty quantification and propagation using full covariance data. The latest ENDF libraries such as TENDL encompass thousands of target isotopes. Nuclear data libraries for Fispact-II are prepared from these using processing codes PREPRO, NJOY and CALENDF. These data include resonance parameters, cross sections with covariances, probability tables in the resonance ranges, PKA spectra, kerma, dpa, gas and radionuclide production and energy-dependent fission yields, supplemented with all 27 decay types. All such data for the five most important incident particles are provided in evaluated data tables. The Fispact-II simulation software is described in detail in this paper, together with the nuclear data libraries. The Fispact-II system also includes several utility programs for code-use optimisation, visualisation and production of secondary radiological quantities. Included in the paper are summaries of results from the suite of verification and validation reports available with the code.« less

  4. FISPACT-II: An Advanced Simulation System for Activation, Transmutation and Material Modelling

    NASA Astrophysics Data System (ADS)

    Sublet, J.-Ch.; Eastwood, J. W.; Morgan, J. G.; Gilbert, M. R.; Fleming, M.; Arter, W.

    2017-01-01

    Fispact-II is a code system and library database for modelling activation-transmutation processes, depletion-burn-up, time dependent inventory and radiation damage source terms caused by nuclear reactions and decays. The Fispact-II code, written in object-style Fortran, follows the evolution of material irradiated by neutrons, alphas, gammas, protons, or deuterons, and provides a wide range of derived radiological output quantities to satisfy most needs for nuclear applications. It can be used with any ENDF-compliant group library data for nuclear reactions, particle-induced and spontaneous fission yields, and radioactive decay (including but not limited to TENDL-2015, ENDF/B-VII.1, JEFF-3.2, JENDL-4.0u, CENDL-3.1 processed into fine-group-structure files, GEFY-5.2 and UKDD-16), as well as resolved and unresolved resonance range probability tables for self-shielding corrections and updated radiological hazard indices. The code has many novel features including: extension of the energy range up to 1 GeV; additional neutron physics including self-shielding effects, temperature dependence, thin and thick target yields; pathway analysis; and sensitivity and uncertainty quantification and propagation using full covariance data. The latest ENDF libraries such as TENDL encompass thousands of target isotopes. Nuclear data libraries for Fispact-II are prepared from these using processing codes PREPRO, NJOY and CALENDF. These data include resonance parameters, cross sections with covariances, probability tables in the resonance ranges, PKA spectra, kerma, dpa, gas and radionuclide production and energy-dependent fission yields, supplemented with all 27 decay types. All such data for the five most important incident particles are provided in evaluated data tables. The Fispact-II simulation software is described in detail in this paper, together with the nuclear data libraries. The Fispact-II system also includes several utility programs for code-use optimisation, visualisation and production of secondary radiological quantities. Included in the paper are summaries of results from the suite of verification and validation reports available with the code.

  5. A workshop on developing risk assessment methods for medical use of radioactive material. Volume 1: Summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tortorelli, J.P.

    1995-08-01

    A workshop was held at the Idaho National Engineering Laboratory, August 16--18, 1994 on the topic of risk assessment on medical devices that use radioactive isotopes. Its purpose was to review past efforts to develop a risk assessment methodology to evaluate these devices, and to develop a program plan and a scoping document for future methodology development. This report contains a summary of that workshop. Participants included experts in the fields of radiation oncology, medical physics, risk assessment, human-error analysis, and human factors. Staff from the US Nuclear Regulatory Commission (NRC) associated with the regulation of medical uses of radioactivemore » materials and with research into risk-assessment methods participated in the workshop. The workshop participants concurred in NRC`s intended use of risk assessment as an important technology in the development of regulations for the medical use of radioactive material and encouraged the NRC to proceed rapidly with a pilot study. Specific recommendations are included in the executive summary and the body of this report. An appendix contains the 8 papers presented at the conference: NRC proposed policy statement on the use of probabilistic risk assessment methods in nuclear regulatory activities; NRC proposed agency-wide implementation plan for probabilistic risk assessment; Risk evaluation of high dose rate remote afterloading brachytherapy at a large research/teaching institution; The pros and cons of using human reliability analysis techniques to analyze misadministration events; Review of medical misadministration event summaries and comparison of human error modeling; Preliminary examples of the development of error influences and effects diagrams to analyze medical misadministration events; Brachytherapy risk assessment program plan; and Principles of brachytherapy quality assurance.« less

  6. Nuclear Structure Aspects in Nuclear Astrophysics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, Michael Scott

    2006-12-01

    Nuclear Astrophysics as a broad and diverse field of study can be viewed as a magnifier of the impact of microscopic processes on the evolution of macroscopic events. One of the primary goals in Nuclear Astrophysics is the understanding of the nucleosynthesis processes that take place in the cosmos and the simulation of the correlated stellar and explosive burning scenarios. These simulations are strongly dependent on the input from Nuclear Physics which sets the time scale for all stellar dynamic processes--from giga-years of stellar evolution to milliseconds of stellar explosions--and provides the basis for most of the signatures that wemore » have for the interpretation of these events--from stellar luminosities, elemental and isotopic abundances to neutrino flux from distant supernovae. The Nuclear Physics input comes through nuclear structure, low energy reaction rates, nuclear masses, and decay rates. There is a common perception that low energy reaction rates are the most important component of the required nuclear physics input; however, in this article we take a broader approach and present an overview of the close correlation between various nuclear structure aspects and their impact on nuclear astrophysics. We discuss the interplay between the weak and the strong forces on stellar time scales due to the limitations they provide for the evolution of slow and rapid burning processes. The effects of shell structure in nuclei on stellar burning processes as well as the impact of clustering in nuclei is outlined. Furthermore we illustrate the effects of the various nuclear structure aspects on the major nucleosynthesis processes that have been identified in the last few decades. We summarize and provide a coherent overview of the impact of all aspects of nuclear structure on nuclear astrophysics.« less

  7. 75 FR 41863 - Structure and Practices of the Video Relay Service Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... Video Relay Service Program AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: In this document, the Commission takes a fresh look at its video relay service (VRS) rules so that the Commission.... SUPPLEMENTARY INFORMATION: This is a summary of the Commission's Structure and Practices of the Video Relay...

  8. Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

    PubMed Central

    Lahaye, Xavier; Satoh, Takeshi; Gentili, Matteo; Cerboni, Silvia; Silvin, Aymeric; Conrad, Cécile; Ahmed-Belkacem, Abdelhakim; Rodriguez, Elisa C.; Guichou, Jean-François; Bosquet, Nathalie; Piel, Matthieu; Le Grand, Roger; King, Megan C.; Pawlotsky, Jean-Michel; Manel, Nicolas

    2016-01-01

    Summary During the early phase of replication, HIV reverse transcribes its RNA and crosses the nuclear envelope while escaping host antiviral defenses. The host factor Cyclophilin A (CypA) is essential for these steps and binds the HIV capsid; however, the mechanism underlying this effect remains elusive. Here, we identify related capsid mutants in HIV-1, HIV-2, and SIVmac that are restricted by CypA. This antiviral restriction of mutated viruses is conserved across species and prevents nuclear import of the viral cDNA. Importantly, the inner nuclear envelope protein SUN2 is required for the antiviral activity of CypA. We show that wild-type HIV exploits SUN2 in primary CD4+ T cells as an essential host factor that is required for the positive effects of CypA on reverse transcription and infection. Altogether, these results establish essential CypA-dependent functions of SUN2 in HIV infection at the nuclear envelope. PMID:27149839

  9. Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule.

    PubMed

    Winteringham, Louise N; Endersby, Raelene; Kobelke, Simon; McCulloch, Ross K; Williams, James H; Stillitano, Justin; Cornwall, Scott M; Ingley, Evan; Klinken, S Peter

    2006-12-15

    Myeloid leukemia factor 1 (MLF1) is an oncoprotein associated with hemopoietic lineage commitment and acute myeloid leukemia. Here we show that Mlf1 associated with a novel binding partner, Mlf1-associated nuclear protein (Manp), a new heterogeneous nuclear ribonucleoprotein (hnRNP) family member, related to hnRNP-U. Manp localized exclusively in the nucleus and could redirect Mlf1 from the cytoplasm into the nucleus. The nuclear content of Mlf1 was also regulated by 14-3-3 binding to a canonical 14-3-3 binding motif within the N terminus of Mlf1. Significantly Mlf1 contains a functional nuclear export signal and localized primarily to the nuclei of hemopoietic cells. Mlf1 was capable of binding DNA, and microarray analysis revealed that it affected the expression of several genes, including transcription factors. In summary, this study reveals that Mlf1 translocates between nucleus and cytoplasm, associates with a novel hnRNP, and influences gene expression.

  10. Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex.

    PubMed Central

    Steiner, G; Hartmuth, K; Skriner, K; Maurer-Fogy, I; Sinski, A; Thalmann, E; Hassfeld, W; Barta, A; Smolen, J S

    1992-01-01

    RA33 is a nuclear autoantigen with an apparent molecular mass of 33 kD. Autoantibodies against RA33 are found in about 30% of sera from RA patients, but only occasionally in sera from patients with other connective tissue diseases. To characterize RA33, the antigen was purified from HeLa cell nuclear extracts to more than 90% homogeneity by affinity chromatography on heparin-Sepharose and by chromatofocusing. Sequence analysis of five tryptic peptides revealed that their sequences matched corresponding sequences of the A2 protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. Furthermore, RA33 was shown to be present in the 40S hnRNP complex and to behave indistinguishably from A2 in binding to single stranded DNA. In summary, these data strongly indicate that RA33 and A2 are the same protein, and thus identify on a molecular level a new autoantigen. Images PMID:1522214

  11. A novel key-frame extraction approach for both video summary and video index.

    PubMed

    Lei, Shaoshuai; Xie, Gang; Yan, Gaowei

    2014-01-01

    Existing key-frame extraction methods are basically video summary oriented; yet the index task of key-frames is ignored. This paper presents a novel key-frame extraction approach which can be available for both video summary and video index. First a dynamic distance separability algorithm is advanced to divide a shot into subshots based on semantic structure, and then appropriate key-frames are extracted in each subshot by SVD decomposition. Finally, three evaluation indicators are proposed to evaluate the performance of the new approach. Experimental results show that the proposed approach achieves good semantic structure for semantics-based video index and meanwhile produces video summary consistent with human perception.

  12. Visualizing the molecular sociology at the HeLa cell nuclear periphery.

    PubMed

    Mahamid, Julia; Pfeffer, Stefan; Schaffer, Miroslava; Villa, Elizabeth; Danev, Radostin; Cuellar, Luis Kuhn; Förster, Friedrich; Hyman, Anthony A; Plitzko, Jürgen M; Baumeister, Wolfgang

    2016-02-26

    The molecular organization of eukaryotic nuclear volumes remains largely unexplored. Here we combined recent developments in cryo-electron tomography (cryo-ET) to produce three-dimensional snapshots of the HeLa cell nuclear periphery. Subtomogram averaging and classification of ribosomes revealed the native structure and organization of the cytoplasmic translation machinery. Analysis of a large dynamic structure-the nuclear pore complex-revealed variations detectable at the level of individual complexes. Cryo-ET was used to visualize previously elusive structures, such as nucleosome chains and the filaments of the nuclear lamina, in situ. Elucidation of the lamina structure provides insight into its contribution to metazoan nuclear stiffness. Copyright © 2016, American Association for the Advancement of Science.

  13. The controversial nuclear matrix: a balanced point of view.

    PubMed

    Martelli, A M; Falcieri, E; Zweyer, M; Bortul, R; Tabellini, G; Cappellini, A; Cocco, L; Manzoli, L

    2002-10-01

    The nuclear matrix is defined as the residual framework after the removal of the nuclear envelope, chromatin, and soluble components by sequential extractions. According to several investigators the nuclear matrix provides the structural basis for intranuclear order. However, the existence itself and the nature of this structure is still uncertain. Although the techniques used for the visualization of the nuclear matrix have improved over the years, it is still unclear to what extent the isolated nuclear matrix corresponds to an in vivo existing structure. Therefore, considerable skepticism continues to surround the nuclear matrix fraction as an accurate representation of the situation in living cells. Here, we summarize the experimental evidence in favor of, or against, the presence of a diffuse nucleoskeleton as a facilitating organizational nonchromatin structure of the nucleus.

  14. Theranostics in nuclear medicine practice.

    PubMed

    Yordanova, Anna; Eppard, Elisabeth; Kürpig, Stefan; Bundschuh, Ralph A; Schönberger, Stefan; Gonzalez-Carmona, Maria; Feldmann, Georg; Ahmadzadehfar, Hojjat; Essler, Markus

    2017-01-01

    The importance of personalized medicine has been growing, mainly due to a more urgent need to avoid unnecessary and expensive treatments. In nuclear medicine, the theranostic approach is an established tool for specific molecular targeting, both for diagnostics and therapy. The visualization of potential targets can help predict if a patient will benefit from a particular treatment. Thanks to the quick development of radiopharmaceuticals and diagnostic techniques, the use of theranostic agents has been continually increasing. In this article, important milestones of nuclear therapies and diagnostics in the context of theranostics are highlighted. It begins with a well-known radioiodine therapy in patients with thyroid cancer and then progresses through various approaches for the treatment of advanced cancer with targeted therapies. The aim of this review was to provide a summary of background knowledge and current applications, and to identify the advantages of targeted therapies and imaging in nuclear medicine practices.

  15. Theranostics in nuclear medicine practice

    PubMed Central

    Yordanova, Anna; Eppard, Elisabeth; Kürpig, Stefan; Bundschuh, Ralph A; Schönberger, Stefan; Gonzalez-Carmona, Maria; Feldmann, Georg; Ahmadzadehfar, Hojjat; Essler, Markus

    2017-01-01

    The importance of personalized medicine has been growing, mainly due to a more urgent need to avoid unnecessary and expensive treatments. In nuclear medicine, the theranostic approach is an established tool for specific molecular targeting, both for diagnostics and therapy. The visualization of potential targets can help predict if a patient will benefit from a particular treatment. Thanks to the quick development of radiopharmaceuticals and diagnostic techniques, the use of theranostic agents has been continually increasing. In this article, important milestones of nuclear therapies and diagnostics in the context of theranostics are highlighted. It begins with a well-known radioiodine therapy in patients with thyroid cancer and then progresses through various approaches for the treatment of advanced cancer with targeted therapies. The aim of this review was to provide a summary of background knowledge and current applications, and to identify the advantages of targeted therapies and imaging in nuclear medicine practices. PMID:29042793

  16. Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress.

    PubMed

    Yang, Yi-Chieh; Chien, Ming-Hsien; Liu, Hsin-Yi; Chang, Yu-Chan; Chen, Chi-Kuan; Lee, Wei-Jiunn; Kuo, Tsang-Chih; Hsiao, Michael; Hua, Kuo-Tai; Cheng, Tsu-Yao

    2018-05-01

    Cancer cells encounter metabolic stresses such as hypoxia and nutrient limitations because they grow and divide more quickly than their normal counterparts. In response to glucose restriction, we found that nuclear translocation of the glycolic enzyme, pyruvate kinase M2 (PKM2), helped cancer cells survive under the metabolic stress. Restriction of glucose stimulated AMPK activation and resulted in co-translocation of AMPK and PKM2 through Ran-mediated nuclear transport. Nuclear PKM2 subsequently bound to Oct4 and promoted the expression of cancer stemness-related genes, which might enrich the cancer stem cell population under the metabolic stress. Nuclear PKM2 was also capable of promoting cancer metastasis in an orthotopic xenograft model. In summary, we found that cytosolic AMPK helped PKM2 carry out its nonmetabolic functions in the nucleus under glucose restriction and that nuclear PKM2 promoted cancer stemness and metastasis. These findings suggested a potential new targeting pathway for cancer therapy in the future. Copyright © 2018 Elsevier B.V. All rights reserved.

  17. A Unique Spatial Arrangement of the snRNPs within the Native Spliceosome Emerges from In-Silico Studies

    PubMed Central

    Frankenstein, Ziv; Sperling, Joseph; Sperling, Ruth; Eisenstein, Miriam

    2012-01-01

    Summary The spliceosome is a mega-Dalton ribonucleoprotein (RNP) assembly that processes primary RNA transcripts, producing functional mRNA. The electron microscopy structures of the native spliceosome and of several spliceosomal subcomplexes are available but the spatial arrangement of the latter within the native spliceosome is not known. We designed a new computational procedure to efficiently fit thousands of conformers into the spliceosome envelope. Despite the low resolution limitations, we obtained only one model that complies with the available biochemical data. Our model localizes the five small nuclear RNPs (snRNPs) mostly within the large subunit of the native spliceosome, requiring only minor conformation changes. The remaining free volume presumably accommodates additional spliceosomal components. The constituents of the active core of the spliceosome are juxtaposed, forming a continuous surface deep within the large spliceosomal cavity, which provides a sheltered environment for the splicing reaction. PMID:22578543

  18. Advanced teleoperation: Technology innovations and applications

    NASA Technical Reports Server (NTRS)

    Schenker, Paul S.; Bejczy, Antal K.; Kim, Won S.

    1994-01-01

    The capability to remotely, robotically perform space assembly, inspection, servicing, and science functions would rapidly expand our presence in space, and the cost efficiency of being there. There is considerable interest in developing 'telerobotic' technologies, which also have comparably important terrestrial applications to health care, underwater salvage, nuclear waste remediation and other. Such tasks, both space and terrestrial, require both a robot and operator interface that is highly flexible and adaptive, i.e., capable of efficiently working in changing and often casually structured environments. One systems approach to this requirement is to augment traditional teleoperation with computer assists -- advanced teleoperation. We have spent a number of years pursuing this approach, and highlight some key technology developments and their potential commercial impact. This paper is an illustrative summary rather than self-contained presentation; for completeness, we include representative technical references to our work which will allow the reader to follow up items of particular interest.

  19. Nuclear Proximity of Mtr4 with RNA exosome restricts DNA mutational asymmetry

    PubMed Central

    Lim, Junghyun; Giri, Pankaj Kumar; Kazadi, David; Laffleur, Brice; Zhang, Wanwei; Grinstein, Veronika; Pefanis, Evangelos; Brown, Lewis M.; Ladewig, Erik; Martin, Ophélie; Chen, Yuling; Rabadan, Raul; Boyer, François; Rothschild, Gerson; Cogné, Michel; Pinaud, Eric; Deng, Haiteng; Basu, Uttiya

    2017-01-01

    SUMMARY The distribution of sense and antisense strand DNA mutations on transcribed duplex DNA contributes to the development of immune and neural systems along with the progression of cancer. Because developmentally matured B cells undergo biologically programmed strand-specific DNA mutagenesis at focal DNA/RNA hybrid structures, they make a convenient system to investigate strand-specific mutagenesis mechanisms. We demonstrate that the sense and antisense strand DNA mutagenesis at the immunoglobulin heavy chain locus and some other regions of the B cell genome depends upon localized RNA processing protein complex formation in the nucleus. Both the physical proximity and coupled activities of RNA helicase Mtr4 (and Senataxin) with the noncoding RNA processing function of RNA exosome determine the strand specific distribution of DNA mutations. Our study suggests that strand-specific DNA mutagenesis-associated mechanisms will play major roles in other undiscovered aspects of organismic development. PMID:28431250

  20. Multivalent small molecule pan-RAS inhibitors

    PubMed Central

    Welsch, Matthew E.; Kaplan, Anna; Chambers, Jennifer M.; Stokes, Michael E.; Bos, Pieter H.; Zask, Arie; Zhang, Yan; Sanchez-Martin, Marta; Badgley, Michael A.; Huang, Christine S.; Tran, Timothy H.; Akkiraju, Hemanth; Brown, Lewis M.; Nandakumar, Renu; Cremers, Serge; Yang, Wan S.; Tong, Liang; Olive, Kenneth P.; Ferrando, Adolfo; Stockwell, Brent R.

    2017-01-01

    SUMMARY Design of small molecules that disrupt protein-protein interactions, including the interaction of RAS proteins and their effectors, have potential use as chemical probes and therapeutic agents. We describe here the synthesis and testing of potential small molecule pan-RAS ligands, which were designed to interact with adjacent sites on the surface of oncogenic KRAS. One compound, termed 3144, was found to bind to RAS proteins using microscale thermophoresis, nuclear magnetic resonance spectroscopy and isothermal titration calorimetry, and to exhibit lethality in cells partially dependent on expression of RAS proteins. This compound was metabolically stable in liver microsomes and displayed anti-tumor activity in xenograft mouse cancer models. These findings suggest that pan-RAS inhibition may be an effective therapeutic strategy for some cancers, and that structure-based design of small molecules targeting multiple adjacent sites to create multivalent inhibitors may be effective for some proteins. PMID:28235199

  1. White paper on nuclear astrophysics and low energy nuclear physics Part 1: Nuclear astrophysics

    DOE PAGES

    Arcones, Almudena; Bardayan, Dan W.; Beers, Timothy C.; ...

    2016-12-28

    This white paper informs the nuclear astrophysics community and funding agencies about the scientific directions and priorities of the field and provides input from this community for the 2015 Nuclear Science Long Range Plan. It also summarizes the outcome of the nuclear astrophysics town meeting that was held on August 21–23, 2014 in College Station at the campus of Texas A&M University in preparation of the NSAC Nuclear Science Long Range Plan. It also reflects the outcome of an earlier town meeting of the nuclear astrophysics community organized by the Joint Institute for Nuclear Astrophysics (JINA) on October 9–10, 2012more » Detroit, Michigan, with the purpose of developing a vision for nuclear astrophysics in light of the recent NRC decadal surveys in nuclear physics (NP2010) and astronomy (ASTRO2010). Our white paper is informed informed by the town meeting of the Association of Research at University Nuclear Accelerators (ARUNA) that took place at the University of Notre Dame on June 12–13, 2014. In summary we find that nuclear astrophysics is a modern and vibrant field addressing fundamental science questions at the intersection of nuclear physics and astrophysics. These questions relate to the origin of the elements, the nuclear engines that drive life and death of stars, and the properties of dense matter. A broad range of nuclear accelerator facilities, astronomical observatories, theory efforts, and computational capabilities are needed. Answers to long standing key questions are well within reach in the coming decade because of the developments outlined in this white paper.« less

  2. White paper on nuclear astrophysics and low energy nuclear physics Part 1: Nuclear astrophysics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arcones, Almudena; Bardayan, Dan W.; Beers, Timothy C.

    This white paper informs the nuclear astrophysics community and funding agencies about the scientific directions and priorities of the field and provides input from this community for the 2015 Nuclear Science Long Range Plan. It also summarizes the outcome of the nuclear astrophysics town meeting that was held on August 21–23, 2014 in College Station at the campus of Texas A&M University in preparation of the NSAC Nuclear Science Long Range Plan. It also reflects the outcome of an earlier town meeting of the nuclear astrophysics community organized by the Joint Institute for Nuclear Astrophysics (JINA) on October 9–10, 2012more » Detroit, Michigan, with the purpose of developing a vision for nuclear astrophysics in light of the recent NRC decadal surveys in nuclear physics (NP2010) and astronomy (ASTRO2010). Our white paper is informed informed by the town meeting of the Association of Research at University Nuclear Accelerators (ARUNA) that took place at the University of Notre Dame on June 12–13, 2014. In summary we find that nuclear astrophysics is a modern and vibrant field addressing fundamental science questions at the intersection of nuclear physics and astrophysics. These questions relate to the origin of the elements, the nuclear engines that drive life and death of stars, and the properties of dense matter. A broad range of nuclear accelerator facilities, astronomical observatories, theory efforts, and computational capabilities are needed. Answers to long standing key questions are well within reach in the coming decade because of the developments outlined in this white paper.« less

  3. White Paper on Nuclear Astrophysics and Low Energy Nuclear Physics - Part 1. Nuclear Astrophysics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arcones, Almudena; Escher, Jutta E.; Others, M.

    This white paper informs the nuclear astrophysics community and funding agencies about the scientific directions and priorities of the field and provides input from this community for the 2015 Nuclear Science Long Range Plan. It summarizes the outcome of the nuclear astrophysics town meeting that was held on August 21 - 23, 2014 in College Station at the campus of Texas A&M University in preparation of the NSAC Nuclear Science Long Range Plan. It also reflects the outcome of an earlier town meeting of the nuclear astrophysics community organized by the Joint Institute for Nuclear Astrophysics (JINA) on October 9more » - 10, 2012 Detroit, Michigan, with the purpose of developing a vision for nuclear astrophysics in light of the recent NRC decadal surveys in nuclear physics (NP2010) and astronomy (ASTRO2010). The white paper is furthermore informed by the town meeting of the Association of Research at University Nuclear Accelerators (ARUNA) that took place at the University of Notre Dame on June 12 - 13, 2014. In summary we find that nuclear astrophysics is a modern and vibrant field addressing fundamental science questions at the intersection of nuclear physics and astrophysics. These questions relate to the origin of the elements, the nuclear engines that drive life and death of stars, and the properties of dense matter. A broad range of nuclear accelerator facilities, astronomical observatories, theory efforts, and computational capabilities are needed. With the developments outlined in this white paper, answers to long-standing key questions are well within reach in the coming decade.« less

  4. White paper on nuclear astrophysics and low energy nuclear physics Part 1: Nuclear astrophysics

    NASA Astrophysics Data System (ADS)

    Arcones, Almudena; Bardayan, Dan W.; Beers, Timothy C.; Bernstein, Lee A.; Blackmon, Jeffrey C.; Messer, Bronson; Brown, B. Alex; Brown, Edward F.; Brune, Carl R.; Champagne, Art E.; Chieffi, Alessandro; Couture, Aaron J.; Danielewicz, Pawel; Diehl, Roland; El-Eid, Mounib; Escher, Jutta E.; Fields, Brian D.; Fröhlich, Carla; Herwig, Falk; Hix, William Raphael; Iliadis, Christian; Lynch, William G.; McLaughlin, Gail C.; Meyer, Bradley S.; Mezzacappa, Anthony; Nunes, Filomena; O'Shea, Brian W.; Prakash, Madappa; Pritychenko, Boris; Reddy, Sanjay; Rehm, Ernst; Rogachev, Grigory; Rutledge, Robert E.; Schatz, Hendrik; Smith, Michael S.; Stairs, Ingrid H.; Steiner, Andrew W.; Strohmayer, Tod E.; Timmes, F. X.; Townsley, Dean M.; Wiescher, Michael; Zegers, Remco G. T.; Zingale, Michael

    2017-05-01

    This white paper informs the nuclear astrophysics community and funding agencies about the scientific directions and priorities of the field and provides input from this community for the 2015 Nuclear Science Long Range Plan. It summarizes the outcome of the nuclear astrophysics town meeting that was held on August 21-23, 2014 in College Station at the campus of Texas A&M University in preparation of the NSAC Nuclear Science Long Range Plan. It also reflects the outcome of an earlier town meeting of the nuclear astrophysics community organized by the Joint Institute for Nuclear Astrophysics (JINA) on October 9-10, 2012 Detroit, Michigan, with the purpose of developing a vision for nuclear astrophysics in light of the recent NRC decadal surveys in nuclear physics (NP2010) and astronomy (ASTRO2010). The white paper is furthermore informed by the town meeting of the Association of Research at University Nuclear Accelerators (ARUNA) that took place at the University of Notre Dame on June 12-13, 2014. In summary we find that nuclear astrophysics is a modern and vibrant field addressing fundamental science questions at the intersection of nuclear physics and astrophysics. These questions relate to the origin of the elements, the nuclear engines that drive life and death of stars, and the properties of dense matter. A broad range of nuclear accelerator facilities, astronomical observatories, theory efforts, and computational capabilities are needed. With the developments outlined in this white paper, answers to long standing key questions are well within reach in the coming decade.

  5. International perceptions of US nuclear policy.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stanley, Elizabeth A.

    The report presents a summary of international perceptions and beliefs about US nuclear policy, focusing on four countries--China, Iran, Pakistan and Germany--chosen because they span the spectrum of states with which the United States has relationships. A paradox is pointed out: that although the goal of US nuclear policy is to make the United States and its allies safer through a policy of deterrence, international perceptions of US nuclear policy may actually be making the US less safe by eroding its soft power and global leadership position. Broadly held perceptions include a pattern of US hypocrisy and double standards--one setmore » for the US and its allies, and another set for all others. Importantly, the US nuclear posture is not seen in a vacuum, but as one piece of the United States behavior on the world stage. Because of this, the potential direct side effects of any negative international perceptions of US nuclear policy can be somewhat mitigated, dependent on other US policies and actions. The more indirect and long term relation of US nuclear policy to US international reputation and soft power, however, matters immensely to successful multilateral and proactive engagement on other pressing global issues.« less

  6. Chemical Technology Division: Progress report, January 1, 1987--June 30, 1988

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1989-02-01

    This progress report summarizes the research and development efforts conducted in the Chemical Technology Division (Chem Tech) during the period January 1, 1987, to June 30, 1988. The following major areas are covered: waste management and environmental programs, radiochemical and reactor engineering programs, basic science and technology, Nuclear Regulatory Commission programs, and administrative resources and facilities. The Administrative Summary, an appendix, presents a comprehensive listing of publications, oral presentations, awards and recognitions, and patents of Chem Tech staff members during this period. A staffing level and financial summary and lists of seminars and Chem Tech consultants for the period aremore » also included.« less

  7. ANALYTICAL CHEMISTRY IN NUCLEAR REACTOR TECHNOLOGY. Analysis of Reactor Fuels, Fission-Product Mixtures and Related Materials: Analytical Chemistry of Plutonium and the Transplutonic Elements. Third Conference, Gatlinburg, Tennessee, October 26-29, 1959

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1960-01-01

    Thirty-one papers and 10 summaries of papers presented at the Third Conference on Analytical Chemistry in Nuclear Reactor Technology held at Gatlinburg, Tennessee, October 26 to 29, 1959, are given. The papers are grouped into four sections: general, analytical chemistry of fuels, analytical chemistry of plutonium and the transplutonic elements, and the analysis of fission-product mixtures. Twenty-seven of the papers are covered by separate abstracts. Four were previously abstracted for NSA. (M.C.G.)

  8. Summary of the study of disposal of nuclear waste into space

    NASA Technical Reports Server (NTRS)

    Rom, F. E.

    1973-01-01

    The space shuttle together with expendable and nonexpendable orbital stages such as the space tug or Centaur can safely dispose of waste material by ejecting it from the solar system. The safety problems associated with all phases of launching and operation (normal, emergency, and accident) of such a system are being examined. It appears that solutions can be found that should make the risks acceptable when compared to the benefits to be obtained from the disposal of the nuclear waste. The techniques proposed to make such a system acceptable need to be carefully verified by further study and experiment.

  9. Laboratory Directed Research and Development LDRD-FY-2011

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dena Tomchak

    2012-03-01

    This report provides a summary of the research conducted at the Idaho National Laboratory (INL) during Fiscal Year (FY) 2011. This report demonstrates the types of cutting edge research the INL is performing to help ensure the nation's energy security. The research conducted under this program is aligned with our strategic direction, benefits the Department of Energy (DOE) and is in compliance with DOE order 413.2B. This report summarizes the diverse research and development portfolio with emphasis on the DOE Office of Nuclear Energy (DOE-NE) mission, encompassing both advanced nuclear science and technology and underlying technologies.

  10. New Brunswick Laboratory: Progress report, October 1987--September 1988

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    NBL has been tasked by the DOE Office of Safeguards and Security, Defense Programs (OSS/DP) to assure the application of accurate and reliable measurement technology for the safeguarding of special nuclear materials. NBL is fulfilling its mission responsibilities by identifying and addressing the measurement and measurement-related needs of the nuclear material safeguards community. These responsibilities are being addressed by activities in the following program areas: (1) reference and calibration materials, (2) measurement development, (3) measurement services, (4) measurement evaluation, (5) safeguards assessment, and (6) site-specific assistance. Highlights of each of these programs areas are provided in this summary.

  11. OAST Space Theme Workshop. Volume 3: Working group summary. 7: Material (M-1). A. Statement. B. Technology needs (form 1). C. Priority assessment (form 2)

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The approach of matching technology areas with various themes needs was not effective for the materials and thermal control discipline because of the diversity of requirements for each. Top priorities were evolved from the advanced space transportation system and the space power platform because these are essential building blocks in fulfilling some of the other themes. Important needs identified include life long-life cryogenic cooling systems for sensors, masers, and other devices and the needs for lightweight nuclear shielding materials for nuclear electric propulsion.

  12. OFFSITE ENVIRONMENTAL MONITORING REPORT. RADIATION MONITORING AROUND UNITED STATES NUCLEAR TEST AREAS, CALENDAR YEAR 1981

    EPA Science Inventory

    This report, prepared in accordance with the guidelines in DOE/E-0023 (DOE 1981), covers the program activities conducted around Nevada Test Site (NTS) for calendar year 1981. It contains descriptions of pertinent features of the NTS and its environs, summaries of the dosimetry a...

  13. SUMMARY OF ACCIDENTAL RELEASES OF RADIOACTIVITY DETECTED OFF THE NEVADA TEST SITE, 1963-1986

    EPA Science Inventory

    Of the more than 450 underground nuclear explosives tests conducted at the Nevada Test Site from August 1963 (signing of the Limited Test Ban Treaty) through the end of 1986, only 23 accidentally released radioactivity that was detectable beyond the boundary of the NTS. Of these ...

  14. Working Parents Project. Final Report. Executive Summary.

    ERIC Educational Resources Information Center

    Mason, Theresa; Espinoza, Renato

    Summarized in this report is a study designed to explore the interrelationships that develop over time between two of the most important aspects of people's lives: their work and their families. Specifically, the study focuses on how the nature of women's jobs influences the system of nuclear family relationships and affects parents' involvement…

  15. 77 FR 3259 - Notice of Intent To Prepare an Environmental Impact Statement for the Disposition of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... of Wetlands Involvement AGENCY: National Nuclear Security Administration (NNSA), U.S. Department of... scoping meeting, and notice of wetlands involvement. SUMMARY: Pursuant to the National Environmental... BFC known as the Kansas City Plant (KCP), consisting of approximately 122 acres and 38 buildings. GSA...

  16. Hiroshima: A City with Peace as Its Purpose.

    ERIC Educational Resources Information Center

    Nesbitt, Donna

    1998-01-01

    Employs a summary of the story "Sadako and the Thousand Paper Cranes" by Eleanor Coerr as an introduction to the city of Hiroshima's (Japan) quest for world peace, peace education, and strong opposition to nuclear warfare. Discusses various symbols of peace, such as paper cranes in Japanese culture, and offers five teaching activities.…

  17. 76 FR 23629 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ...: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: Nuclear Regulatory Commission (NRC). ACTION: Notice of the OMB review of information collection and solicitation of public comment. SUMMARY: The NRC has recently submitted to OMB for review the following proposal for the...

  18. 76 FR 9614 - Notice of Availability of the Proposed Models for Plant-Specific Adoption of Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... NUCLEAR REGULATORY COMMISSION [NRC-2011-0039] Notice of Availability of the Proposed Models for..., ``Technical Specifications End States, NEDC-32988-A,'' for Boiling Water Reactor Plants Using the Consolidated... Availability. SUMMARY: The NRC is announcing the availability of the model application (with model no...

  19. An Evaluation of Very Large Airplanes and Alternative Fuels: Executive Summary

    DTIC Science & Technology

    1976-12-01

    the AIAA/ SAE Eleventh Prop~ilsion Conference, Anaheim, Cal., September 1975. i 33 Rom, F. E., "Nuclear-Powered Airplane," Technology Heview, December...Department of Defense Directive No. 4140 -43, December 5, 1975. Scarbrough, D. R., C-5B and Austere C-5 Data Package, Lockheed-Georgia Co., Operations

  20. 77 FR 76474 - Extension of Public Review and Comment Period for the Draft Programmatic Environmental Assessment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... Nuclear Security Administration (NNSA) Web site at: http://www.nnsa.energy.gov/nepa . Comments on the... DEPARTMENT OF ENERGY Extension of Public Review and Comment Period for the Draft Programmatic...: Department of Energy. ACTION: Extension of public review and comment period. SUMMARY: On December 12, 2012...

  1. 78 FR 29392 - Embedded Digital Devices in Safety-Related Systems, Systems Important to Safety, and Items Relied...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0098] Embedded Digital Devices in Safety-Related Systems... (NRC) is issuing for public comment Draft Regulatory Issue Summary (RIS) 2013-XX, ``Embedded Digital... requirements for the quality and reliability of basic components with embedded digital devices. DATES: Submit...

  2. 75 FR 81315 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: U. S. Nuclear Regulatory Commission (NRC). ACTION: Notice of the OMB review of information collection and solicitation of public comment. SUMMARY: The NRC has recently submitted to OMB for review the following proposal for the...

  3. 77 FR 46766 - Public Meeting To Discuss Revision of “Criteria for Preparation and Evaluation of Radiological...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2012-0026...) AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice of public meetings. SUMMARY: The Federal Emergency Management Agency (FEMA) and the U.S. Nuclear Regulatory Commission (NRC) will hold two public...

  4. 77 FR 25104 - Petition for Rulemaking; Submitted by the Natural Resources Defense Council, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    .... ACTION: Petition for rulemaking; consideration in the rulemaking process. SUMMARY: The U.S. Nuclear...), in the rulemaking process. The petitioner requested that the NRC amend its regulations to require... may examine and purchase copies of public documents at the NRC's PDR, O1-F21, One White Flint North...

  5. Use of a structured palliative care summary in patients with established cancer is associated with reduced hospital admissions by out-of-hours general practitioners in Grampian.

    PubMed

    Ali, Asia Andeleeb; Adam, Rosalind; Taylor, David; Murchie, Peter

    2013-12-01

    Palliative care summaries are used by general practices to provide structured anticipatory care information to those providing care during the out-of-hours period. We hypothesised that the availability of a palliative care summary for individuals with established cancer would influence emergency hospital admission during the out-of-hours period. Each consultation with Grampian Medical Emergency Department (GMED) is recorded on the ADASTRA software system and the nature of the consultation is Read coded. We retrospectively reviewed consultations between 1 January 2011 and 31 December 2011 which had been coded as 'neoplasm' or 'terminal care'. The availability of a palliative care summary on ADASTRA and admission status were recorded. χ(2) Test of association was performed. Binary logistic regression was used for multivariate analysis exploring the effect of a palliative care summary on admission, while adjusting for important confounders. 401 patients with established cancer were identified who had presented to GMED in 2011. 35.7% had a palliative care summary available on ADASTRA. Of the 401 contacts, 100 patients were admitted to hospital. Not having a palliative care summary made admission significantly more likely; χ(2)=12.480, p=0.001. (OR 2.425, 95% CI 1.412 to 4.165). Availability of a structured palliative care plan can aid decision making in the out-of-hours period and prevent unplanned hospital admissions.

  6. The nuclear matrix prepared by amine modification

    PubMed Central

    Wan, Katherine M.; Nickerson, Jeffrey A.; Krockmalnic, Gabriela; Penman, Sheldon

    1999-01-01

    The nucleus is spatially ordered by attachments to a nonchromatin nuclear structure, the nuclear matrix. The nuclear matrix and chromatin are intimately connected and integrated structures, and so a major technical challenge in nuclear matrix research has been to remove chromatin while retaining a native nuclear matrix. Most methods for removing chromatin require first a nuclease digestion and then a salt extraction to remove cut chromatin. We have hypothesized that cut chromatin is held in place by charge interactions involving nucleosomal amino groups. We have tested this hypothesis by chemically modifying amino groups after nuclease digestion. By using this protocol, chromatin could be effectively removed at physiological ionic strength. We compared the ultrastructure and composition of this nuclear matrix preparation with the traditional high-salt nuclear matrix and with the third nuclear matrix preparation that we have developed from which chromatin is removed after extensive crosslinking. All three matrix preparations reveal internal nuclear matrix structures that are built on a network of branched filaments of about 10 nm diameter. That such different chromatin-removal protocols reveal similar principles of nuclear matrix construction increases our confidence that we are observing important architectural elements of the native structure in the living cell. PMID:9927671

  7. ENDF/B summary documentation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kinsey, R.

    1979-07-01

    This publication provides a localized source of descriptions for the evaluations contained in the ENDF/B Library. The summary documentation presented is intended to be a more detailed description than the (File 1) comments contained in the computer readable data files, but not so detailed as the formal reports describing each ENDF/B evaluation. The summary documentations were written by the CSEWB (Cross Section Evaluation Working Group) evaluators and compiled by NNDC (National Nuclear Data Center). This edition includes documentation for materials found on ENDF/B Version V tapes 501 to 516 (General Purpose File) excluding tape 504. ENDF/B-V also includes tapes containingmore » partial evaluations for the Special Purpose Actinide (521, 522), Dosimetry (531), Activation (532), Gas Production (533), and Fission Product (541-546) files. The materials found on these tapes are documented elsewhere. Some of the evaluation descriptions in this report contain cross sections or energy level information. (RWR)« less

  8. Integrative structure and functional anatomy of a nuclear pore complex

    NASA Astrophysics Data System (ADS)

    Kim, Seung Joong; Fernandez-Martinez, Javier; Nudelman, Ilona; Shi, Yi; Zhang, Wenzhu; Raveh, Barak; Herricks, Thurston; Slaughter, Brian D.; Hogan, Joanna A.; Upla, Paula; Chemmama, Ilan E.; Pellarin, Riccardo; Echeverria, Ignacia; Shivaraju, Manjunatha; Chaudhury, Azraa S.; Wang, Junjie; Williams, Rosemary; Unruh, Jay R.; Greenberg, Charles H.; Jacobs, Erica Y.; Yu, Zhiheng; de La Cruz, M. Jason; Mironska, Roxana; Stokes, David L.; Aitchison, John D.; Jarrold, Martin F.; Gerton, Jennifer L.; Ludtke, Steven J.; Akey, Christopher W.; Chait, Brian T.; Sali, Andrej; Rout, Michael P.

    2018-03-01

    Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation. Here we determined the structure of the entire 552-protein nuclear pore complex of the yeast Saccharomyces cerevisiae at sub-nanometre precision by satisfying a wide range of data relating to the molecular arrangement of its constituents. The nuclear pore complex incorporates sturdy diagonal columns and connector cables attached to these columns, imbuing the structure with strength and flexibility. These cables also tie together all other elements of the nuclear pore complex, including membrane-interacting regions, outer rings and RNA-processing platforms. Inwardly directed anchors create a high density of transport factor-docking Phe-Gly repeats in the central channel, organized into distinct functional units. This integrative structure enables us to rationalize the architecture, transport mechanism and evolutionary origins of the nuclear pore complex.

  9. Integrative structure and functional anatomy of a nuclear pore complex.

    PubMed

    Kim, Seung Joong; Fernandez-Martinez, Javier; Nudelman, Ilona; Shi, Yi; Zhang, Wenzhu; Raveh, Barak; Herricks, Thurston; Slaughter, Brian D; Hogan, Joanna A; Upla, Paula; Chemmama, Ilan E; Pellarin, Riccardo; Echeverria, Ignacia; Shivaraju, Manjunatha; Chaudhury, Azraa S; Wang, Junjie; Williams, Rosemary; Unruh, Jay R; Greenberg, Charles H; Jacobs, Erica Y; Yu, Zhiheng; de la Cruz, M Jason; Mironska, Roxana; Stokes, David L; Aitchison, John D; Jarrold, Martin F; Gerton, Jennifer L; Ludtke, Steven J; Akey, Christopher W; Chait, Brian T; Sali, Andrej; Rout, Michael P

    2018-03-22

    Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation. Here we determined the structure of the entire 552-protein nuclear pore complex of the yeast Saccharomyces cerevisiae at sub-nanometre precision by satisfying a wide range of data relating to the molecular arrangement of its constituents. The nuclear pore complex incorporates sturdy diagonal columns and connector cables attached to these columns, imbuing the structure with strength and flexibility. These cables also tie together all other elements of the nuclear pore complex, including membrane-interacting regions, outer rings and RNA-processing platforms. Inwardly directed anchors create a high density of transport factor-docking Phe-Gly repeats in the central channel, organized into distinct functional units. This integrative structure enables us to rationalize the architecture, transport mechanism and evolutionary origins of the nuclear pore complex.

  10. Condensins exert force on chromatin-nuclear envelope tethers to mediate nucleoplasmic reticulum formation in Drosophila melanogaster.

    PubMed

    Bozler, Julianna; Nguyen, Huy Q; Rogers, Gregory C; Bosco, Giovanni

    2014-12-30

    Although the nuclear envelope is known primarily for its role as a boundary between the nucleus and cytoplasm in eukaryotes, it plays a vital and dynamic role in many cellular processes. Studies of nuclear structure have revealed tissue-specific changes in nuclear envelope architecture, suggesting that its three-dimensional structure contributes to its functionality. Despite the importance of the nuclear envelope, the factors that regulate and maintain nuclear envelope shape remain largely unexplored. The nuclear envelope makes extensive and dynamic interactions with the underlying chromatin. Given this inexorable link between chromatin and the nuclear envelope, it is possible that local and global chromatin organization reciprocally impact nuclear envelope form and function. In this study, we use Drosophila salivary glands to show that the three-dimensional structure of the nuclear envelope can be altered with condensin II-mediated chromatin condensation. Both naturally occurring and engineered chromatin-envelope interactions are sufficient to allow chromatin compaction forces to drive distortions of the nuclear envelope. Weakening of the nuclear lamina further enhanced envelope remodeling, suggesting that envelope structure is capable of counterbalancing chromatin compaction forces. Our experiments reveal that the nucleoplasmic reticulum is born of the nuclear envelope and remains dynamic in that they can be reabsorbed into the nuclear envelope. We propose a model where inner nuclear envelope-chromatin tethers allow interphase chromosome movements to change nuclear envelope morphology. Therefore, interphase chromatin compaction may be a normal mechanism that reorganizes nuclear architecture, while under pathological conditions, such as laminopathies, compaction forces may contribute to defects in nuclear morphology. Copyright © 2015 Bozler et al.

  11. Condensins Exert Force on Chromatin-Nuclear Envelope Tethers to Mediate Nucleoplasmic Reticulum Formation in Drosophila melanogaster

    PubMed Central

    Bozler, Julianna; Nguyen, Huy Q.; Rogers, Gregory C.; Bosco, Giovanni

    2014-01-01

    Although the nuclear envelope is known primarily for its role as a boundary between the nucleus and cytoplasm in eukaryotes, it plays a vital and dynamic role in many cellular processes. Studies of nuclear structure have revealed tissue-specific changes in nuclear envelope architecture, suggesting that its three-dimensional structure contributes to its functionality. Despite the importance of the nuclear envelope, the factors that regulate and maintain nuclear envelope shape remain largely unexplored. The nuclear envelope makes extensive and dynamic interactions with the underlying chromatin. Given this inexorable link between chromatin and the nuclear envelope, it is possible that local and global chromatin organization reciprocally impact nuclear envelope form and function. In this study, we use Drosophila salivary glands to show that the three-dimensional structure of the nuclear envelope can be altered with condensin II-mediated chromatin condensation. Both naturally occurring and engineered chromatin-envelope interactions are sufficient to allow chromatin compaction forces to drive distortions of the nuclear envelope. Weakening of the nuclear lamina further enhanced envelope remodeling, suggesting that envelope structure is capable of counterbalancing chromatin compaction forces. Our experiments reveal that the nucleoplasmic reticulum is born of the nuclear envelope and remains dynamic in that they can be reabsorbed into the nuclear envelope. We propose a model where inner nuclear envelope-chromatin tethers allow interphase chromosome movements to change nuclear envelope morphology. Therefore, interphase chromatin compaction may be a normal mechanism that reorganizes nuclear architecture, while under pathological conditions, such as laminopathies, compaction forces may contribute to defects in nuclear morphology. PMID:25552604

  12. Reduced rank regression via adaptive nuclear norm penalization

    PubMed Central

    Chen, Kun; Dong, Hongbo; Chan, Kung-Sik

    2014-01-01

    Summary We propose an adaptive nuclear norm penalization approach for low-rank matrix approximation, and use it to develop a new reduced rank estimation method for high-dimensional multivariate regression. The adaptive nuclear norm is defined as the weighted sum of the singular values of the matrix, and it is generally non-convex under the natural restriction that the weight decreases with the singular value. However, we show that the proposed non-convex penalized regression method has a global optimal solution obtained from an adaptively soft-thresholded singular value decomposition. The method is computationally efficient, and the resulting solution path is continuous. The rank consistency of and prediction/estimation performance bounds for the estimator are established for a high-dimensional asymptotic regime. Simulation studies and an application in genetics demonstrate its efficacy. PMID:25045172

  13. Nuclear matrix and structural and functional compartmentalization of the eucaryotic cell nucleus.

    PubMed

    Razin, S V; Borunova, V V; Iarovaia, O V; Vassetzky, Y S

    2014-07-01

    Becoming popular at the end of the 20th century, the concept of the nuclear matrix implies the existence of a nuclear skeleton that organizes functional elements in the cell nucleus. This review presents a critical analysis of the results obtained in the study of nuclear matrix in the light of current views on the organization of the cell nucleus. Numerous studies of nuclear matrix have failed to provide evidence of the existence of such a structure. Moreover, the existence of a filamentous structure that supports the nuclear compartmentalization appears to be unnecessary, since this function is performed by the folded genome itself.

  14. Evaluated nuclear structure data file

    NASA Astrophysics Data System (ADS)

    Tuli, J. K.

    1996-02-01

    The Evaluated Nuclear Structure Data File (ENSDF) contains the evaluated nuclear properties of all known nuclides, as derived both from nuclear reaction and radioactive decay measurements. All experimental data are evaluated to create the adopted properties for each nuclide. ENSDF, together with other numeric and bibliographic files, can be accessed on-line through the INTERNET or modem, and some of the databases are also available on the World Wide Web. The structure and the scope of ENSDF are presented along with the on-line access system of the National Nuclear Data Center at Brookhaven National Laboratory.

  15. Evaluated nuclear structure data file

    NASA Astrophysics Data System (ADS)

    Tuli, J. K.

    The Evaluated Nuclear Structure Data File (ENSDF) contains the evaluated nuclear properties of all known nuclides. These properties are derived both from nuclear reaction and radioactive decay measurements. All experimental data are evaluated to create the adopted properties for each nuclide. ENSDF, together with other numeric and biographic files, can be accessed on-line through the INTERNET or modem. Some of the databases are also available on the World Wide Web. The structure and the scope of ENSDF are presented along with the on-line access system of the National Nuclear Data Center at Brookhaven National Laboratory.

  16. Generalized Nuclear Data: A New Structure (with Supporting Infrastructure) for Handling Nuclear Data

    NASA Astrophysics Data System (ADS)

    Mattoon, C. M.; Beck, B. R.; Patel, N. R.; Summers, N. C.; Hedstrom, G. W.; Brown, D. A.

    2012-12-01

    The Evaluated Nuclear Data File (ENDF) format was designed in the 1960s to accommodate neutron reaction data to support nuclear engineering applications in power, national security and criticality safety. Over the years, the scope of the format has been extended to handle many other kinds of data including charged particle, decay, atomic, photo-nuclear and thermal neutron scattering. Although ENDF has wide acceptance and support for many data types, its limited support for correlated particle emission, limited numeric precision, and general lack of extensibility mean that the nuclear data community cannot take advantage of many emerging opportunities. More generally, the ENDF format provides an unfriendly environment that makes it difficult for new data evaluators and users to create and access nuclear data. The Cross Section Evaluation Working Group (CSEWG) has begun the design of a new Generalized Nuclear Data (or 'GND') structure, meant to replace older formats with a hierarchy that mirrors the underlying physics, and is aligned with modern coding and database practices. In support of this new structure, Lawrence Livermore National Laboratory (LLNL) has updated its nuclear data/reactions management package Fudge to handle GND structured nuclear data. Fudge provides tools for converting both the latest ENDF format (ENDF-6) and the LLNL Evaluated Nuclear Data Library (ENDL) format to and from GND, as well as for visualizing, modifying and processing (i.e., converting evaluated nuclear data into a form more suitable to transport codes) GND structured nuclear data. GND defines the structure needed for storing nuclear data evaluations and the type of data that needs to be stored. But unlike ENDF and ENDL, GND does not define how the data are to be stored in a file. Currently, Fudge writes the structured GND data to a file using the eXtensible Markup Language (XML), as it is ASCII based and can be viewed with any text editor. XML is a meta-language, meaning that it has a primitive set of definitions for representing hierarchical data/text in a file. Other meta-languages, like HDF5 which stores the data in binary form, can also be used to store GND in a file. In this paper, we will present an overview of the new GND data structures along with associated tools in Fudge.

  17. Expression of DNAJB12 or DNAJB14 Causes Coordinate Invasion of the Nucleus by Membranes Associated with a Novel Nuclear Pore Structure

    PubMed Central

    Goodwin, Edward C.; Motamedi, Nasim; Lipovsky, Alex; Fernández-Busnadiego, Rubén; DiMaio, Daniel

    2014-01-01

    DNAJB12 and DNAJB14 are transmembrane proteins in the endoplasmic reticulum (ER) that serve as co-chaperones for Hsc70/Hsp70 heat shock proteins. We demonstrate that over-expression of DNAJB12 or DNAJB14 causes the formation of elaborate membranous structures within cell nuclei, which we designate DJANGOS for DNAJ-associated nuclear globular structures. DJANGOS contain DNAJB12, DNAJB14, Hsc70 and markers of the ER lumen and ER and nuclear membranes. Strikingly, they are evenly distributed underneath the nuclear envelope and are of uniform size in any one nucleus. DJANGOS are composed primarily of single-walled membrane tubes and sheets that connect to the nuclear envelope via a unique configuration of membranes, in which the nuclear pore complex appears anchored exclusively to the outer nuclear membrane, allowing both the inner and outer nuclear membranes to flow past the circumference of the nuclear pore complex into the nucleus. DJANGOS break down rapidly during cell division and reform synchronously in the daughter cell nuclei, demonstrating that they are dynamic structures that undergo coordinate formation and dissolution. Genetic studies showed that the chaperone activity of DNAJ/Hsc70 is required for the formation of DJANGOS. Further analysis of these structures will provide insight into nuclear pore formation and function, activities of molecular chaperones, and mechanisms that maintain membrane identity. PMID:24732912

  18. Automatic analysis of medical dialogue in the home hemodialysis domain: structure induction and summarization.

    PubMed

    Lacson, Ronilda C; Barzilay, Regina; Long, William J

    2006-10-01

    Spoken medical dialogue is a valuable source of information for patients and caregivers. This work presents a first step towards automatic analysis and summarization of spoken medical dialogue. We first abstract a dialogue into a sequence of semantic categories using linguistic and contextual features integrated in a supervised machine-learning framework. Our model has a classification accuracy of 73%, compared to 33% achieved by a majority baseline (p<0.01). We then describe and implement a summarizer that utilizes this automatically induced structure. Our evaluation results indicate that automatically generated summaries exhibit high resemblance to summaries written by humans. In addition, task-based evaluation shows that physicians can reasonably answer questions related to patient care by looking at the automatically generated summaries alone, in contrast to the physicians' performance when they were given summaries from a naïve summarizer (p<0.05). This work demonstrates the feasibility of automatically structuring and summarizing spoken medical dialogue.

  19. Argonne Physics Division

    Science.gov Websites

    , nuclear structure and reaction research, nuclear theory, medium energy nuclear research and accelerator structure of baryonic matter in the universe - the matter that makes up stars, planets and human life itself

  20. Molecular and Structural Traits of Insulin Receptor Substrate 1/LC3 Nuclear Structures and Their Role in Autophagy Control and Tumor Cell Survival.

    PubMed

    Lassak, Adam; Dean, Mathew; Wyczechowska, Dorota; Wilk, Anna; Marrero, Luis; Trillo-Tinoco, Jimena; Boulares, A Hamid; Sarkaria, Jann N; Del Valle, Luis; Peruzzi, Francesca; Ochoa, Augusto; Reiss, Krzysztof

    2018-05-15

    Insulin receptor substrate 1 (IRS-1) is a common cytosolic adaptor molecule involved in signal transduction from insulin and insulin-like growth factor I (IGF-I) receptors. IRS-1 can also be found in the nucleus. We report here a new finding of unique IRS-1 nuclear structures, which we observed initially in glioblastoma biopsy specimens and glioblastoma xenografts. These nuclear structures can be reproduced in vitro by the ectopic expression of IRS-1 cDNA cloned in frame with the nuclear localization signal (NLS-IRS-1). In these structures, IRS-1 localizes at the periphery, while the center harbors a key autophagy protein, LC3. These new nuclear structures are highly dynamic, rapidly exchange IRS-1 molecules with the surrounding nucleoplasm, disassemble during mitosis, and require a growth stimulus for their reassembly and maintenance. In tumor cells engineered to express NLS-IRS-1, the IRS-1/LC3 nuclear structures repress autophagy induced by either amino acid starvation or rapamycin treatment. In this process, IRS-1 nuclear structures sequester LC3 inside the nucleus, possibly preventing its cytosolic translocation and the formation of new autophagosomes. This novel mechanism provides a quick and reversible way of inhibiting autophagy, which could counteract autophagy-induced cancer cell death under severe stress, including anticancer therapies. Copyright © 2018 American Society for Microbiology.

  1. Nuclear data and related services

    NASA Astrophysics Data System (ADS)

    Tuli, J. K.

    1985-10-01

    National Nuclear Data Center (NNDC) maintains a number of data bases containing bibliographic information and evaluated as well as experimental nuclear properties. An evaluated computer file maintained by the NNDC, called the Evaluated Nuclear Structure Data File (ENSDF), contains nuclear structure information for all known nuclides. The ENSDF is the source for the journal Nuclear Data Sheets which is produced and edited by NNDC. The Evaluated Nuclear Data File (ENDF), on the other hand is designed for storage and retrieval of such evaluated nuclear data as are used in neutronic, photonic, and decay heat calculations in a large variety of applications. Some of the publications from these data bases are the Nuclear Wallet Cards, Radioactivity Handbook, and books on neutron cross sections and resonance parameters. In addition, the NNDC maintains three bibliographic files: NSR - for nuclear structure and decay data related references, CINDA - a bibliographic file for neutron induced reactions, and CPBIB for charged particle reactions. Selected retrievals from evaluated data and bibliographic files are possible on-line or on request from NNDC.

  2. Customizing clinical narratives for the electronic medical record interface using cognitive methods.

    PubMed

    Sharda, Pallav; Das, Amar K; Cohen, Trevor A; Patel, Vimla

    2006-05-01

    As healthcare practice transitions from paper-based to computer-based records, there is increasing need to determine an effective electronic format for clinical narratives. Our research focuses on utilizing a cognitive science methodology to guide the conversion of medical texts to a more structured, user-customized presentation in the electronic medical record (EMR). We studied the use of discharge summaries by psychiatrists with varying expertise-experts, intermediates, and novices. Experts were given two hypothetical emergency care scenarios with narrative discharge summaries and asked to verbalize their clinical assessment. Based on the results, the narratives were presented in a more structured form. Intermediate and novice subjects received a narrative and a structured discharge summary, and were asked to verbalize their assessments of each. A qualitative comparison of the interview transcripts of all subjects was done by analysis of recall and inference made with respect to level of expertise. For intermediate and novice subjects, recall was greater with the structured form than with the narrative. Novices were also able to make more inferences (not always accurate) from the structured form than with the narrative. Errors occurred in assessments using the narrative form but not the structured form. Our cognitive methods to study discharge summary use enabled us to extract a conceptual representation of clinical narratives from end-users. This method allowed us to identify clinically relevant information that can be used to structure medical text for the EMR and potentially improve recall and reduce errors.

  3. FY2007 Laboratory Directed Research and Development Annual Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Craig, W W; Sketchley, J A; Kotta, P R

    The Laboratory Directed Research and Development (LDRD) annual report for fiscal year 2007 (FY07) provides a summary of LDRD-funded projects for the fiscal year and consists of two parts: An introduction to the LDRD Program, the LDRD portfolio-management process, program statistics for the year, and highlights of accomplishments for the year. A summary of each project, submitted by the principal investigator. Project summaries include the scope, motivation, goals, relevance to Department of Energy (DOE)/National Nuclear Security Administration (NNSA) and Lawrence Livermore National Laboratory (LLNL) mission areas, the technical progress achieved in FY07, and a list of publications that resulted frommore » the research in FY07. Summaries are organized in sections by research category (in alphabetical order). Within each research category, the projects are listed in order of their LDRD project category: Strategic Initiative (SI), Exploratory Research (ER), Laboratory-Wide Competition (LW), and Feasibility Study (FS). Within each project category, the individual project summaries appear in order of their project tracking code, a unique identifier that consists of three elements. The first is the fiscal year the project began, the second represents the project category, and the third identifies the serial number of the proposal for that fiscal year.« less

  4. FY 1992-1993 RDT&E Descriptive Summaries: DARPA

    DTIC Science & Technology

    1991-02-01

    combining natural language and user workflow model information. * Determine effectiveness of auditory models as preprocessors for robust speech...for indexing and retrieving design knowledge. * Evaluate ability of message understanding systems to extract crisis -situation data from news wires...energy effects , underwater vehicles, neutrino detection, speech, tailored nuclear weapons, hypervelocity, nanosecond timing, and MAD/RPV. FY 1991 Planned

  5. List of DOE radioisotope customers with summary of radioisotope shipments FY 1978

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burlison, J.S.; Laidler, R.I.

    1979-05-01

    The purpose of the document is to list DOE's radioisotopes production and distribution activities by its facilities at Argonne National Laboratory; Pacific Northwest Laboratory; Brookhaven National Laboratory; Hanford Engineering Development Laboratory; Idaho Operations Office; Los Alamos Scientific Laboratory; Mound Facility; Oak Ridge National Laboratory; Savannah River Laboratory; and UNC Nuclear Industries, Inc.

  6. 75 FR 59297 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ...: Submission for the Office of Management and Budget (OMB) Review; Comment Request AGENCY: U.S. Nuclear Regulatory Commission (NRC). ACTION: Notice of the OMB review of information collection and solicitation of public comment. SUMMARY: The NRC has recently submitted to OMB for review the following proposal for the...

  7. A hydrogen energy carrier. Volume 1: Summary. [for meeting energy requirements

    NASA Technical Reports Server (NTRS)

    Savage, R. L. (Editor); Blank, L. (Editor); Cady, T. (Editor); Cox, K. E. (Editor); Murray, R. (Editor); Williams, R. D. (Editor)

    1973-01-01

    The production, technology, transportation, and implementation of hydrogen into the energy system are discussed along with the fossil fuel cycle, hydrogen fuel cycle, and the demands for energy. The cost of hydrogen production by coal gasification; electrolysis by nuclear energy, and solar energy are presented. The legal aspects of a hydrogen economy are also discussed.

  8. 78 FR 28897 - Lost Creek ISR, LLC, Lost Creek Uranium In-Situ Recovery Project; Sweetwater County, Wyoming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... ISR, LLC, Lost Creek Uranium In-Situ Recovery Project; Sweetwater County, Wyoming AGENCY: Nuclear... amendment, correction. SUMMARY: This document corrects a notice appearing in the Federal Register on April 3, 2013 [78 FR 20146], that listed, in tabular format, documents that related to the notice. This action...

  9. 75 FR 54384 - Notice of Intent To Prepare an Environmental Impact Statement for the Gas Hills Uranium Project...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ..., the reader is referred to the Nuclear Regulatory Commission's Generic EIS of In-Situ Leach Uranium.... SUMMARY: Pursuant to the National Environmental Policy Act of 1969, as amended, (NEPA) and in response to... to solicit public comments regarding issues and resource information for the proposed Gas Hills in...

  10. 78 FR 26810 - Adequacy of Design Features and Functional Capabilities Identified and Described for Withstanding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-08

    .... ACTION: Standard review plan section; issuance. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is issuing a new section of NUREG-0800, ``Standard Review Plan for the Review of Safety Analysis Reports for... impacts.'' DATES: The effective date of this Standard Review Plan (SRP) update is June 7, 2013. ADDRESSES...

  11. A summary of the SOTANCP3 workshop

    NASA Astrophysics Data System (ADS)

    Baye, Daniel

    2014-12-01

    This text summarizes the talks presented at the 3rd International Workshop on State of the Art in Nuclear Cluster Physics (SOTANCP3) held in Yokohama (Japan) from 26 to 30 May 2014. Some personal opinions are also expressed on two much debated topics: the 12C spectrum in the continuum and conflicting interpretations of cluster wave functions.

  12. Tumour suppressor TRIM33 targets nuclear β-catenin degradation

    PubMed Central

    Xue, Jianfei; Chen, Yaohui; Wu, Yamei; Wang, Zhongyong; Zhou, Aidong; Zhang, Sicong; Lin, Kangyu; Aldape, Kenneth; Majumder, Sadhan; Lu, Zhimin; Huang, Suyun

    2014-01-01

    Aberrant activation of β-catenin in the nucleus has been implicated in a variety of human cancers but the fate of nuclear β-catenin is unknown. Here we demonstrate that tripartite motif-containing protein 33 (TRIM33), acting as an E3 ubiquitin ligase, reduces the abundance of nuclear β-catenin protein. TRIM33-mediated β-catenin is destabilized and is GSK-3β or β-TrCP independent. TRIM33 interacts with and ubiquitylates nuclear β-catenin. Moreover, protein kinase Cδ, which directly phosphorylates β-catenin at Ser715, is required for the TRIM33–β-catenin interaction. The function of TRIM33 in suppressing tumour cell proliferation and brain tumour development depends on TRIM33-promoted β-catenin degradation. In human glioblastoma specimens, endogenous TRIM33 levels are inversely correlated with β-catenin. In summary, our findings identify TRIM33 as a tumour suppressor that can abolish tumour cell proliferation and tumorigenesis by degrading nuclear β-catenin. This work suggests a new therapeutic strategy against human cancers caused by aberrant activation of β-catenin. PMID:25639486

  13. Kaon Condensation and the Non-Uniform Nuclear Matter

    NASA Astrophysics Data System (ADS)

    Maruyama, Toshiki; Tatsumi, Toshitaka; Voskresensky, Dmitri N.; Tanigawa, Tomonori; Chiba, Satoshi

    2004-04-01

    Non-uniform structures of nuclear matter are studied in a wide density-range. Using the density functional theory with a relativistic mean-field model, we examine non-uniform structures at sub-nuclear densities (nuclear "pastas") and at high densities, where kaon condensate is expected. We try to give a unified view about the change of the matter structure as density increases, carefully taking into account the Coulomb screening effects from the viewpoint of first-order phase transition.

  14. Assessment of Titanium Aluminide Alloys for High-Temperature Nuclear Structural Applications

    NASA Astrophysics Data System (ADS)

    Zhu, Hanliang; Wei, Tao; Carr, David; Harrison, Robert; Edwards, Lyndon; Hoffelner, Wolfgang; Seo, Dongyi; Maruyama, Kouichi

    2012-12-01

    Titanium aluminide (TiAl) alloys exhibit high specific strength, low density, good oxidation, corrosion, and creep resistance at elevated temperatures, making them good candidate materials for aerospace and automotive applications. TiAl alloys also show excellent radiation resistance and low neutron activation, and they can be developed to have various microstructures, allowing different combinations of properties for various extreme environments. Hence, TiAl alloys may be used in advanced nuclear systems as high-temperature structural materials. Moreover, TiAl alloys are good materials to be used for fundamental studies on microstructural effects on irradiation behavior of advanced nuclear structural materials. This article reviews the microstructure, creep, radiation, and oxidation properties of TiAl alloys in comparison with other nuclear structural materials to assess the potential of TiAl alloys as candidate structural materials for future nuclear applications.

  15. On the existence of Rydberg nuclear molecules

    NASA Astrophysics Data System (ADS)

    Bertulani, C. A.; Frederico, T.; Hussein, M. S.

    2017-11-01

    Present nuclear detection techniques prevents us from determining if the analogue of a Rydberg molecule exists for the nuclear case. But nothing in nature disallows their existence. As in the atomic case, Rydberg nuclear molecules would be a laboratory for new aspects and applications of nuclear physics. We propose that Rydberg nuclear molecules, which represent the exotic, halo nuclei version, such as 11Be +11Be, of the well known quasimolecules observed in stable nuclei such as 12C +12C, might be common structures that could manifest their existence along the dripline. A study of possible candidates and the expected structure of such exotic clustering of two halo nuclei: the Rydberg nuclear molecules, is made on the basis of three different methods. It is shown that such cluster structures might be stable and unexpectedly common.

  16. A high-performance Fortran code to calculate spin- and parity-dependent nuclear level densities

    NASA Astrophysics Data System (ADS)

    Sen'kov, R. A.; Horoi, M.; Zelevinsky, V. G.

    2013-01-01

    A high-performance Fortran code is developed to calculate the spin- and parity-dependent shell model nuclear level densities. The algorithm is based on the extension of methods of statistical spectroscopy and implies exact calculation of the first and second Hamiltonian moments for different configurations at fixed spin and parity. The proton-neutron formalism is used. We have applied the method for calculating the level densities for a set of nuclei in the sd-, pf-, and pf+g- model spaces. Examples of the calculations for 28Si (in the sd-model space) and 64Ge (in the pf+g-model space) are presented. To illustrate the power of the method we estimate the ground state energy of 64Ge in the larger model space pf+g, which is not accessible to direct shell model diagonalization due to the prohibitively large dimension, by comparing with the nuclear level densities at low excitation energy calculated in the smaller model space pf. Program summaryProgram title: MM Catalogue identifier: AENM_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AENM_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 193181 No. of bytes in distributed program, including test data, etc.: 1298585 Distribution format: tar.gz Programming language: Fortran 90, MPI. Computer: Any architecture with a Fortran 90 compiler and MPI. Operating system: Linux. RAM: Proportional to the system size, in our examples, up to 75Mb Classification: 17.15. External routines: MPICH2 (http://www.mcs.anl.gov/research/projects/mpich2/) Nature of problem: Calculating of the spin- and parity-dependent nuclear level density. Solution method: The algorithm implies exact calculation of the first and second Hamiltonian moments for different configurations at fixed spin and parity. The code is parallelized using the Message Passing Interface and a master-slaves dynamical load-balancing approach. Restrictions: The program uses two-body interaction in a restricted single-level basis. For example, GXPF1A in the pf-valence space. Running time: Depends on the system size and the number of processors used (from 1 min to several hours).

  17. LEAP 96 Conference summary

    NASA Astrophysics Data System (ADS)

    Montanet, Lucien

    1997-06-01

    The following pages represent a short summary of the many new results in low energy antiproton (p¯) physics presented and discussed at the LEAP 96 Conference. They cover a broad field of physics, from atomic physics to nuclear physics, from hadronic physics to parton physics. The impact of these results on "soft QCD", the part of strong interactions which we do not yet understand, and on the limits that we can establish to the "fundamental symmetries" which govern Nature are original and important. Within these twelve pages, I cannot do justice to all contributions. I present my apologizes for the omissions, hoping however that the serious reader will find the missing information in these proceedings.

  18. Francis Bitter National Magnet Laboratory annual report, July 1988 through June 1989

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1989-01-01

    Contents include: reports on laboratory research programs--magneto-optics and semiconductor physics, magnetism, superconductivity, solid-state nuclear magnetic resonance, condensed-matter chemistry, biomagnetism, magnet technology, instrumentation for high-magnetic-field research, molecular biophysics; reports of visiting scientists--reports of users of the High Magnetic Field Facility, reports of users of the Pulsed Field Facility, reports of users of the SQUID Magnetometer and Moessbauer Facility, reports of users of the High-Field NMR Facility; Appendices--publications and meeting speeches, organization, summary of High-Field Magnet Facility use January 1, 1981 through December 31, 1988; geographic distribution of High-Field Magnet users (excluding laboratory staff); and summary of educational activities.

  19. Nuclear Cartography: Patterns in Binding Energies and Subatomic Structure

    ERIC Educational Resources Information Center

    Simpson, E. C.; Shelley, M.

    2017-01-01

    Nuclear masses and binding energies are some of the first nuclear properties met in high school physics, and can be used to introduce radioactive decays, fusion, and fission. With relatively little extension, they can also illustrate fundamental concepts in nuclear physics, such as shell structure and pairing, and to discuss how the elements…

  20. Manned space programs accident/incident summaries (1963 - 1969)

    NASA Technical Reports Server (NTRS)

    1970-01-01

    This summary is a compilation of 508 mishaps assembled from company and NASA records which cover several years of manned space flight activity. The purpose is to provide information to be applied towards accident prevention. The accident/incident summaries are categorized by the following ten systems: cryogenic; electrical; facility/GSE; fuel and propellant; life support; ordnance; pressure; propulsion; structural; and transport/handling. Each accident/incident summary has been summarized by description, cause and recommended preventive action.

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