Sample records for numer methods eng

  1. A comparative study between two smoothing strategies for the simulation of contact with large sliding

    NASA Astrophysics Data System (ADS)

    Batailly, Alain; Magnain, Benoît; Chevaugeon, Nicolas

    2013-05-01

    The numerical simulation of contact problems is still a delicate matter especially when large transformations are involved. In that case, relative large slidings can occur between contact surfaces and the discretization error induced by usual finite elements may not be satisfactory. In particular, usual elements lead to a facetization of the contact surface, meaning an unavoidable discontinuity of the normal vector to this surface. Uncertainty over the precision of the results, irregularity of the displacement of the contact nodes and even numerical oscillations of contact reaction force may result of such discontinuity. Among the existing methods for tackling such issue, one may consider mortar elements (Fischer and Wriggers, Comput Methods Appl Mech Eng 195:5020-5036, 2006; McDevitt and Laursen, Int J Numer Methods Eng 48:1525-1547, 2000; Puso and Laursen, Comput Methods Appl Mech Eng 93:601-629, 2004), smoothing of the contact surfaces with additional geometrical entity (B-splines or NURBS) (Belytschko et al., Int J Numer Methods Eng 55:101-125, 2002; Kikuchi, Penalty/finite element approximations of a class of unilateral contact problems. Penalty method and finite element method, ASME, New York, 1982; Legrand, Modèles de prediction de l'interaction rotor/stator dans un moteur d'avion Thèse de doctorat. PhD thesis, École Centrale de Nantes, Nantes, 2005; Muñoz, Comput Methods Appl Mech Eng 197:979-993, 2008; Wriggers and Krstulovic-Opara, J Appl Math Mech (ZAMM) 80:77-80, 2000) and, the use of isogeometric analysis (Temizer et al., Comput Methods Appl Mech Eng 200:1100-1112, 2011; Hughes et al., Comput Methods Appl Mech Eng 194:4135-4195, 2005; de Lorenzis et al., Int J Numer Meth Eng, in press, 2011). In the present paper, we focus on these last two methods which are combined with a finite element code using the bi-potential method for contact management (Feng et al., Comput Mech 36:375-383, 2005). A comparative study focusing on the pros and cons of each method regarding geometrical precision and numerical stability for contact solution is proposed. The scope of this study is limited to 2D contact problems for which we consider several types of finite elements. Test cases are given in order to illustrate this comparative study.

  2. Advantages of formulating an evolution equation directly for elastic distortional deformation in finite deformation plasticity

    NASA Astrophysics Data System (ADS)

    Rubin, M. B.; Cardiff, P.

    2017-11-01

    Simo (Comput Methods Appl Mech Eng 66:199-219, 1988) proposed an evolution equation for elastic deformation together with a constitutive equation for inelastic deformation rate in plasticity. The numerical algorithm (Simo in Comput Methods Appl Mech Eng 68:1-31, 1988) for determining elastic distortional deformation was simple. However, the proposed inelastic deformation rate caused plastic compaction. The corrected formulation (Simo in Comput Methods Appl Mech Eng 99:61-112, 1992) preserves isochoric plasticity but the numerical integration algorithm is complicated and needs special methods for calculation of the exponential map of a tensor. Alternatively, an evolution equation for elastic distortional deformation can be proposed directly with a simplified constitutive equation for inelastic distortional deformation rate. This has the advantage that the physics of inelastic distortional deformation is separated from that of dilatation. The example of finite deformation J2 plasticity with linear isotropic hardening is used to demonstrate the simplicity of the numerical algorithm.

  3. On making cuts for magnetic scalar potentials in multiply connected regions

    NASA Astrophysics Data System (ADS)

    Kotiuga, P. R.

    1987-04-01

    The problem of making cuts is of importance to scalar potential formulations of three-dimensional eddy current problems. Its heuristic solution has been known for a century [J. C. Maxwell, A Treatise on Electricity and Magnetism, 3rd ed. (Clarendon, Oxford, 1981), Chap. 1, Article 20] and in the last decade, with the use of finite element methods, a restricted combinatorial variant has been proposed and solved [M. L. Brown, Int. J. Numer. Methods Eng. 20, 665 (1984)]. This problem, in its full generality, has never received a rigorous mathematical formulation. This paper presents such a formulation and outlines a rigorous proof of existence. The technique used in the proof expose the incredible intricacy of the general problem and the restrictive assumptions of Brown [Int. J. Numer. Methods Eng. 20, 665 (1984)]. Finally, the results make rigorous Kotiuga's (Ph. D. Thesis, McGill University, Montreal, 1984) heuristic interpretation of cuts and duality theorems via intersection matrices.

  4. Numerical calculation of thermo-mechanical problems at large strains based on complex step derivative approximation of tangent stiffness matrices

    NASA Astrophysics Data System (ADS)

    Balzani, Daniel; Gandhi, Ashutosh; Tanaka, Masato; Schröder, Jörg

    2015-05-01

    In this paper a robust approximation scheme for the numerical calculation of tangent stiffness matrices is presented in the context of nonlinear thermo-mechanical finite element problems and its performance is analyzed. The scheme extends the approach proposed in Kim et al. (Comput Methods Appl Mech Eng 200:403-413, 2011) and Tanaka et al. (Comput Methods Appl Mech Eng 269:454-470, 2014 and bases on applying the complex-step-derivative approximation to the linearizations of the weak forms of the balance of linear momentum and the balance of energy. By incorporating consistent perturbations along the imaginary axis to the displacement as well as thermal degrees of freedom, we demonstrate that numerical tangent stiffness matrices can be obtained with accuracy up to computer precision leading to quadratically converging schemes. The main advantage of this approach is that contrary to the classical forward difference scheme no round-off errors due to floating-point arithmetics exist within the calculation of the tangent stiffness. This enables arbitrarily small perturbation values and therefore leads to robust schemes even when choosing small values. An efficient algorithmic treatment is presented which enables a straightforward implementation of the method in any standard finite-element program. By means of thermo-elastic and thermo-elastoplastic boundary value problems at finite strains the performance of the proposed approach is analyzed.

  5. A new approximation for pore pressure accumulation in marine sediment due to water waves

    NASA Astrophysics Data System (ADS)

    Jeng, D.-S.; Seymour, B. R.; Li, J.

    2007-01-01

    The residual mechanism of wave-induced pore water pressure accumulation in marine sediments is re-examined. An analytical approximation is derived using a linear relation for pore pressure generation in cyclic loading, and mistakes in previous solutions (Int. J. Numer. Anal. Methods Geomech. 2001; 25:885-907; J. Offshore Mech. Arctic Eng. (ASME) 1989; 111(1):1-11) are corrected. A numerical scheme is then employed to solve the case with a non-linear relation for pore pressure generation. Both analytical and numerical solutions are verified with experimental data (Laboratory and field investigation of wave-sediment interaction. Joseph H. Defrees Hydraulics Laboratory, School of Civil and Environmental Engineering, Cornell University, Ithaca, NY, 1983), and provide a better prediction of pore pressure accumulation than the previous solution (J. Offshore Mech. Arctic Eng. (ASME) 1989; 111(1):1-11). The parametric study concludes that the pore pressure accumulation and use of full non-linear relation of pore pressure become more important under the following conditions: (1) large wave amplitude, (2) longer wave period, (3) shallow water, (4) shallow soil and (5) softer soils with a low consolidation coefficient. Copyright

  6. Small Engine Technology (SET) - Task 14 Axisymmetric Engine Simulation Environment

    NASA Technical Reports Server (NTRS)

    Miller, Max J.

    1999-01-01

    As part of the NPSS (Numerical Propulsion Simulation System) project, NASA Lewis has a goal of developing an U.S. industry standard for an axisymmetric engine simulation environment. In this program, AlliedSignal Engines (AE) contributed to this goal by evaluating the ENG20 software and developing support tools. ENG20 is a NASA developed axisymmetric engine simulation tool. The project was divided into six subtasks which are summarized below: Evaluate the capabilities of the ENG20 code using an existing test case to see how this procedure can capture the component interactions for a full engine. Link AE's compressor and turbine axisymmetric streamline curvature codes (UD0300M and TAPS) with ENG20, which will provide the necessary boundary conditions for an ENG20 engine simulation. Evaluate GE's Global Data System (GDS), attempt to use GDS to do the linking of codes described in Subtask 2 above. Use a turbofan engine test case to evaluate various aspects of the system, including the linkage of UD0300M and TAPS with ENG20 and the GE data storage system. Also, compare the solution results with cycle deck results, axisymmetric solutions (UD0300M and TAPS), and test data to determine the accuracy of the solution. Evaluate the order of accuracy and the convergence time for the solution. Provide a monthly status report and a final formal report documenting AE's evaluation of ENG20. Provide the developed interfaces that link UD0300M and TAPS with ENG20, to NASA. The interface that links UD0300M with ENG20 will be compatible with the industr,, version of UD0300M.

  7. A metagenome-derived thermostable β-glucanase with an unusual module architecture which defines the new glycoside hydrolase family GH148.

    PubMed

    Angelov, Angel; Pham, Vu Thuy Trang; Übelacker, Maria; Brady, Silja; Leis, Benedikt; Pill, Nicole; Brolle, Judith; Mechelke, Matthias; Moerch, Matthias; Henrissat, Bernard; Liebl, Wolfgang

    2017-12-11

    The discovery of novel and robust enzymes for the breakdown of plant biomass bears tremendous potential for the development of sustainable production processes in the rapidly evolving new bioeconomy. By functional screening of a metagenomic library from a volcano soil sample a novel thermostable endo-β-glucanase (EngU) which is unusual with regard to its module architecture and cleavage specificity was identified. Various recombinant EngU variants were characterized. Assignment of EngU to an existing glycoside hydrolase (GH) family was not possible. Two regions of EngU showed weak sequence similarity to proteins of the GH clan GH-A, and acidic residues crucial for catalytic activity of EngU were identified by mutation. Unusual, a carbohydrate-binding module (CBM4) which displayed binding affinity for β-glucan, lichenin and carboxymethyl-cellulose was found as an insertion between these two regions. EngU hydrolyzed β-1,4 linkages in carboxymethyl-cellulose, but displayed its highest activity with mixed linkage (β-1,3-/β-1,4-) glucans such as barley β-glucan and lichenin, where in contrast to characterized lichenases cleavage occurred predominantly at the β-1,3 linkages of C4-substituted glucose residues. EngU and numerous related enzymes with previously unknown function represent a new GH family of biomass-degrading enzymes within the GH-A clan. The name assigned to the new GH family is GH148.

  8. Numerical Modelling of Solitary Wave Experiments on Rubble Mound Breakwaters

    NASA Astrophysics Data System (ADS)

    Guler, H. G.; Arikawa, T.; Baykal, C.; Yalciner, A. C.

    2016-12-01

    Performance of a rubble mound breakwater protecting Haydarpasa Port, Turkey, has been tested under tsunami attack by physical model tests conducted at Port and Airport Research Institute (Guler et al, 2015). It is aimed to understand dynamic force of the tsunami by conducting solitary wave tests (Arikawa, 2015). In this study, the main objective is to perform numerical modelling of solitary wave tests in order to verify accuracy of the CFD model IHFOAM, developed in OpenFOAM environment (Higuera et al, 2013), by comparing results of the numerical computations with the experimental results. IHFOAM is the numerical modelling tool which is based on VARANS equations with a k-ω SST turbulence model including realistic wave generation, and active wave absorption. Experiments are performed using a Froude scale of 1/30, measuring surface elevation and flow velocity at several locations in the wave channel, and wave pressure around the crown wall of the breakwater. Solitary wave tests with wave heights of H=7.5 cm and H=10 cm are selected which represent the results of the experiments. The first test (H=7.5 cm) is the case that resulted in no damage whereas the second case (H=10 cm) resulted in total damage due to the sliding of the crown wall. After comparison of the preliminary results of numerical simulations with experimental data for both cases, it is observed that solitary wave experiments could be accurately modeled using IHFOAM focusing water surface elevations, flow velocities, and wave pressures on the crown wall of the breakwater (Figure, result of sim. at t=29.6 sec). ACKNOWLEDGEMENTSThe authors acknowledge developers of IHFOAM, further extend their acknowledgements for the partial supports from the research projects MarDiM, ASTARTE, RAPSODI, and TUBITAK 213M534. REFERENCESArikawa (2015) "Consideration of Characteristics of Pressure on Seawall by Solitary Waves Based on Hydraulic Experiments", Jour. of Japan. Soc. of Civ. Eng. Ser. B2 (Coast. Eng.), Vol 71, p I889-I894 Guler, Arikawa, Oei, Yalciner (2015) "Performance of Rubble Mound Breakwaters under Tsunami Attack, A Case Study: Haydarpasa Port, Istanbul, Turkey", Coast. Eng. 104, 43-53 Higuera, Lara, Losada (2013) "Realistic Wave Generation and Active Wave Absorption for Navier-Stokes Models, Application to OpenFOAM", Coast. Eng. 71, 102-118

  9. A New Homotopy Perturbation Scheme for Solving Singular Boundary Value Problems Arising in Various Physical Models

    NASA Astrophysics Data System (ADS)

    Roul, Pradip; Warbhe, Ujwal

    2017-08-01

    The classical homotopy perturbation method proposed by J. H. He, Comput. Methods Appl. Mech. Eng. 178, 257 (1999) is useful for obtaining the approximate solutions for a wide class of nonlinear problems in terms of series with easily calculable components. However, in some cases, it has been found that this method results in slowly convergent series. To overcome the shortcoming, we present a new reliable algorithm called the domain decomposition homotopy perturbation method (DDHPM) to solve a class of singular two-point boundary value problems with Neumann and Robin-type boundary conditions arising in various physical models. Five numerical examples are presented to demonstrate the accuracy and applicability of our method, including thermal explosion, oxygen-diffusion in a spherical cell and heat conduction through a solid with heat generation. A comparison is made between the proposed technique and other existing seminumerical or numerical techniques. Numerical results reveal that only two or three iterations lead to high accuracy of the solution and this newly improved technique introduces a powerful improvement for solving nonlinear singular boundary value problems (SBVPs).

  10. Analysis and computation of a least-squares method for consistent mesh tying

    DOE PAGES

    Day, David; Bochev, Pavel

    2007-07-10

    We report in the finite element method, a standard approach to mesh tying is to apply Lagrange multipliers. If the interface is curved, however, discretization generally leads to adjoining surfaces that do not coincide spatially. Straightforward Lagrange multiplier methods lead to discrete formulations failing a first-order patch test [T.A. Laursen, M.W. Heinstein, Consistent mesh-tying methods for topologically distinct discretized surfaces in non-linear solid mechanics, Internat. J. Numer. Methods Eng. 57 (2003) 1197–1242]. This paper presents a theoretical and computational study of a least-squares method for mesh tying [P. Bochev, D.M. Day, A least-squares method for consistent mesh tying, Internat. J.more » Numer. Anal. Modeling 4 (2007) 342–352], applied to the partial differential equation -∇ 2φ+αφ=f. We prove optimal convergence rates for domains represented as overlapping subdomains and show that the least-squares method passes a patch test of the order of the finite element space by construction. To apply the method to subdomain configurations with gaps and overlaps we use interface perturbations to eliminate the gaps. Finally, theoretical error estimates are illustrated by numerical experiments.« less

  11. High-performance parallel analysis of coupled problems for aircraft propulsion

    NASA Technical Reports Server (NTRS)

    Felippa, C. A.; Farhat, C.; Chen, P.-S.; Gumaste, U.; Leoinne, M.; Stern, P.

    1995-01-01

    This research program deals with the application of high-performance computing methods to the numerical simulation of complete jet engines. The program was initiated in 1993 by applying two-dimensional parallel aeroelastic codes to the interior gas flow problem of a by-pass jet engine. The fluid mesh generation, domain decomposition and solution capabilities were successfully tested. Attention was then focused on methodology for the partitioned analysis of the interaction of the gas flow with a flexible structure and with the fluid mesh motion driven by these structural displacements. The latter is treated by an ALE technique that models the fluid mesh motion as that of a fictitious mechanical network laid along the edges of near-field fluid elements. New partitioned analysis procedures to treat this coupled 3-component problem were developed in 1994. These procedures involved delayed corrections and subcycling, and have been successfully tested on several massively parallel computers. For the global steady-state axisymmetric analysis of a complete engine we have decided to use the NASA-sponsored ENG10 program, which uses a regular FV-multiblock-grid discretization in conjunction with circumferential averaging to include effects of blade forces, loss, combustor heat addition, blockage, bleeds and convective mixing. A load-balancing preprocessor for parallel versions of ENG10 has been developed. It is planned to use the steady-state global solution provided by ENG10 as input to a localized three-dimensional FSI analysis for engine regions where aeroelastic effects may be important.

  12. Simulation of chemical-vapor-deposited silicon carbide for a cold wall vertical reactor

    NASA Astrophysics Data System (ADS)

    Lee, Y. L.; Sanchez, J. M.

    1997-07-01

    The growth rate of silicon carbide obtained by low-pressure chemical vapor deposition from tetramethylsilane is numerically simulated for a cold wall vertical reactor. The transport equations for momentum, heat, and mass transfer are simultaneously solved by employing the finite volume method. A model for reaction rate is also proposed in order to predict the measured growth rates [A. Figueras, S. Garelik, J. Santiso, R. Rodroguez-Clemente, B. Armas, C. Combescure, R. Berjoan, J.M. Saurel and R. Caplain, Mater. Sci. Eng. B 11 (1992) 83]. Finally, the effects of thermal diffusion on the growth rate are investigated.

  13. A unified monolithic approach for multi-fluid flows and fluid-structure interaction using the Particle Finite Element Method with fixed mesh

    NASA Astrophysics Data System (ADS)

    Becker, P.; Idelsohn, S. R.; Oñate, E.

    2015-06-01

    This paper describes a strategy to solve multi-fluid and fluid-structure interaction (FSI) problems using Lagrangian particles combined with a fixed finite element (FE) mesh. Our approach is an extension of the fluid-only PFEM-2 (Idelsohn et al., Eng Comput 30(2):2-2, 2013; Idelsohn et al., J Numer Methods Fluids, 2014) which uses explicit integration over the streamlines to improve accuracy. As a result, the convective term does not appear in the set of equations solved on the fixed mesh. Enrichments in the pressure field are used to improve the description of the interface between phases.

  14. Body composition and bone mineral density in users of the etonogestrel-releasing contraceptive implant.

    PubMed

    Modesto, Waleska; Dal Ava, Natália; Monteiro, Ilza; Bahamondes, Luis

    2015-12-01

    There is scarce information about bone mineral density (BMD) and body composition (BC) among users of the etonogestrel (ENG)-releasing implant. To evaluate BC and BMD in ENG-releasing implant users as compared to copper intrauterine device (Cu-IUD)-users. A prospective study was conducted on 75 users of both contraceptive methods. BMD was evaluated at femoral neck (FN) and lumbar spine (LS) (L1-L4) and BC at baseline and at 12 months after insertion. The mean (±SD) age was 30.4 ± 6.8 and 29.8 ± 8.4 years and body mass index (kg/m(2)) was 24.9 ± 4.1 and 24.6 ± 3.5 in ENG-releasing implant- and Cu-IUD-users, respectively. ENG-releasing implant users did not show significant differences on BMD at the LS and FN at 12 months of use. Furthermore, ENG-implant users had an increase in body weight at 12 months (p < 0.001) and an increase of 2 % in the percentage of body fat, when compared with Cu-IUD users. There was a significant increase in lean mass in ENG-implant users at 12 months (p = 0.020). No significant changes of BMD were seen after the first year of use among the ENG-releasing implant-users, albeit an increase of weight and fat mass was seen when compared to Cu-IUD users.

  15. Simulating Astrophysical Jets with Inertial Confinement Fusion Machines

    NASA Astrophysics Data System (ADS)

    Blue, Brent

    2005-10-01

    Large-scale directional outflows of supersonic plasma, also known as `jets', are ubiquitous phenomena in astrophysics. The traditional approach to understanding such phenomena is through theoretical analysis and numerical simulations. However, theoretical analysis might not capture all the relevant physics and numerical simulations have limited resolution and fail to scale correctly in Reynolds number and perhaps other key dimensionless parameters. Recent advances in high energy density physics using large inertial confinement fusion devices now allow controlled laboratory experiments on macroscopic volumes of plasma of direct relevance to astrophysics. This talk will present an overview of these facilities as well as results from current laboratory astrophysics experiments designed to study hydrodynamic jets and Rayleigh-Taylor mixing. This work is performed under the auspices of the U. S. DOE by Lawrence Livermore National Laboratory under Contract No. W-7405-ENG-48, Los Alamos National Laboratory under Contract No. W-7405-ENG-36, and the Laboratory for Laser Energetics under Contract No. DE-FC03-92SF19460.

  16. Modeling Supernova Shocks with Intense Lasers.

    NASA Astrophysics Data System (ADS)

    Blue, Brent

    2006-04-01

    Large-scale directional outflows of supersonic plasma are ubiquitous phenomena in astrophysics, with specific application to supernovae. The traditional approach to understanding such phenomena is through theoretical analysis and numerical simulations. However, theoretical analysis might not capture all the relevant physics and numerical simulations have limited resolution and fail to scale correctly in Reynolds number and perhaps other key dimensionless parameters. Recent advances in high energy density physics using large inertial confinement fusion devices now allow controlled laboratory experiments on macroscopic volumes of plasma of direct relevance to astrophysics. This talk will present an overview of these facilities as well as results from current laboratory astrophysics experiments designed to study hydrodynamic jets and Rayleigh-Taylor mixing. This work is performed under the auspices of the U. S. DOE by Lawrence Livermore National Laboratory under Contract No. W-7405-ENG-48, Los Alamos National Laboratory under Contract No. W-7405-ENG-36, and the Laboratory for Laser Energetics under Contract No. DE-FC03-92SF19460.

  17. Modeling surface topography of state-of-the-art x-ray mirrors as a result of stochastic polishing process: recent developments

    NASA Astrophysics Data System (ADS)

    Yashchuk, Valeriy V.; Centers, Gary; Tyurin, Yuri N.; Tyurina, Anastasia

    2016-09-01

    Recently, an original method for the statistical modeling of surface topography of state-of-the-art mirrors for usage in xray optical systems at light source facilities and for astronomical telescopes [Opt. Eng. 51(4), 046501, 2012; ibid. 53(8), 084102 (2014); and ibid. 55(7), 074106 (2016)] has been developed. In modeling, the mirror surface topography is considered to be a result of a stationary uniform stochastic polishing process and the best fit time-invariant linear filter (TILF) that optimally parameterizes, with limited number of parameters, the polishing process is determined. The TILF model allows the surface slope profile of an optic with a newly desired specification to be reliably forecast before fabrication. With the forecast data, representative numerical evaluations of expected performance of the prospective mirrors in optical systems under development become possible [Opt. Eng., 54(2), 025108 (2015)]. Here, we suggest and demonstrate an analytical approach for accounting the imperfections of the used metrology instruments, which are described by the instrumental point spread function, in the TILF modeling. The efficacy of the approach is demonstrated with numerical simulations for correction of measurements performed with an autocollimator based surface slope profiler. Besides solving this major metrological problem, the results of the present work open an avenue for developing analytical and computational tools for stitching data in the statistical domain, obtained using multiple metrology instruments measuring significantly different bandwidths of spatial wavelengths.

  18. A modified Gurson-type plasticity model at finite strains: formulation, numerical analysis and phase-field coupling

    NASA Astrophysics Data System (ADS)

    Aldakheel, Fadi; Wriggers, Peter; Miehe, Christian

    2017-12-01

    The modeling of failure in ductile materials must account for complex phenomena at the micro-scale, such as nucleation, growth and coalescence of micro-voids, as well as the final rupture at the macro-scale, as rooted in the work of Gurson (J Eng Mater Technol 99:2-15, 1977). Within a top-down viewpoint, this can be achieved by the combination of a micro-structure-informed elastic-plastic model for a porous medium with a concept for the modeling of macroscopic crack discontinuities. The modeling of macroscopic cracks can be achieved in a convenient way by recently developed continuum phase field approaches to fracture, which are based on the regularization of sharp crack discontinuities, see Miehe et al. (Comput Methods Appl Mech Eng 294:486-522, 2015). This avoids the use of complex discretization methods for crack discontinuities, and can account for complex crack patterns. In this work, we develop a new theoretical and computational framework for the phase field modeling of ductile fracture in conventional elastic-plastic solids under finite strain deformation. It combines modified structures of Gurson-Tvergaard-Needelman GTN-type plasticity model outlined in Tvergaard and Needleman (Acta Metall 32:157-169, 1984) and Nahshon and Hutchinson (Eur J Mech A Solids 27:1-17, 2008) with a new evolution equation for the crack phase field. An important aspect of this work is the development of a robust Explicit-Implicit numerical integration scheme for the highly nonlinear rate equations of the enhanced GTN model, resulting with a low computational cost strategy. The performance of the formulation is underlined by means of some representative examples, including the development of the experimentally observed cup-cone failure mechanism.

  19. Masculinities in Organizational Cultures in Engineering Education in Europe: Results of the European Union Project WomEng

    ERIC Educational Resources Information Center

    Sagebiel, F.; Dahmen, J.

    2006-01-01

    The paper describes elements of engineering organizational cultures and structures in higher engineering education from the European project WomEng. Hypotheses, based on state of the art, refer to: women friendly presentation, attractiveness of interdisciplinary teaching methods, single sex education, perceptions of minority status, feelings of…

  20. Twelve-month discontinuation rates of levonorgestrel intrauterine system 13.5 mg and subdermal etonogestrel implant in women aged 18-44: A retrospective claims database analysis.

    PubMed

    Law, Amy; Liao, Laura; Lin, Jay; Yaldo, Avin; Lynen, Richard

    2018-04-21

    To investigate the 12-month discontinuation rates of levonorgestrel intrauterine system 13.5 mg (LNG-IUS 13.5) and subdermal etonogestrel (ENG) implant in the US. We identified women aged 18-44 who had an insertion of LNG-IUS 13.5 or ENG implant from the MarketScan Commercial claims database (7/1/2013-9/30/2014). Women were required to have 12 months of continuous insurance coverage prior to the insertion (baseline) and at least 12-months after (follow-up). Discontinuation was defined as presence of an insurance claim for pregnancy-related services, hysterectomy, female sterilization, a claim for another contraceptive method, or removal of the index contraceptive without re-insertion within 30 days. Using Cox regression we examined the potential impact of ENG implant vs. LNG-IUS 13.5 on the likelihood for discontinuation after controlling for patient characteristics. A total of 3680 (mean age: 25.4 years) LNG-IUS 13.5 and 23,770 (mean age: 24.6 years) ENG implant users met the selection criteria. Prior to insertion, 56.6% of LNG-IUS 13.5 and 42.1% of ENG implant users had used contraceptives, with oral contraceptives being most common (LNG-IUS 13.5: 42.1%; ENG implant: 28.5%). Among users of LNG-IUS 13.5 and ENG implant, rates of discontinuation were similar during the 12-month follow-up (LNG-IUS 13.5: 24.9%; ENG implant: 24.0%). Regression results showed that women using LNG-IUS 13.5 vs. ENG implant had similar likelihood for discontinuation (hazard ratio: 0.97, 95% confidence interval: 0.90-1.05, p=.41). In the real-world US setting, women aged 18-44 using LNG-IUS 13.5 and ENG implant have similar discontinuation rates after 12 months. In the United States, women aged 18-44 using levonorgestrel intrauterine system (13.5 mg) and subdermal etonogestrel implant have similar discontinuation rates after 12 months. Copyright © 2018 Elsevier Inc. All rights reserved.

  1. Towards medium-term (order of months) morphodynamic modelling of the Teign estuary, UK

    NASA Astrophysics Data System (ADS)

    Bernardes, Marcos E. C.; Davidson, Mark A.; Dyer, Keith R.; George, Ken J.

    2006-07-01

    The main objective of this paper is to address the principal mechanisms involved in the medium-term (order of months to years) morphodynamic evolution of estuaries through the application of a process-based numerical modelling. The Teign estuary (Teignmouth, UK) is the selected site. The system is forced by the macrotidal semi-diurnal tide in the English Channel and is perturbed to a minor extent by high river discharge events (freshets). Although waves have a definite influence on the adjacent coastal area, Wells (Teignmouth Quay Development Environmental Statement: Changes to Physical Processes. Report R.984c:140. ABP Marine Environmental Research Ltd., Southampton, 2002b) suggested that swell waves do not enter the estuary. Hence, wave effects are neglected in this study, as only tides and the river discharge are taken into account. The sediment grain size is highly variable, but mainly sandy. Within the frame of the COAST3D project ( http://www.hrwallingford.co.uk/projects/COAST3D ), four bathymetric surveys of the adjacent coastal area were carried out at a nearly weekly intervals. The outer estuary and the adjacent coastal area were also surveyed every 6 months as part of the COASTVIEW project ( http://thecoastviewproject.org ). Based on these data and on continuously measured parameters, such as water level, waves, wind and river discharge, numerical modelling of the morphodynamic processes can be tested. To replicate the morphological changes in the medium-term within a feasible simulation time, forcing conditions are reduced through the use of an input reduction method (called ensemble technique). In this study, simulations are based on the coupling between Telemac-2D and its non-cohesive sediment transport module, Sisyphe (version 5.3 for both modules). Three different sediment transport formulae were tested: (1) Engelund and Hansen (A monograph on sediment transport in alluvial streams, 3rd edn. Technological University of Denmark, Copenhagen, 1967) including the modifications proposed by Chollet and Cunge (J Hydraul Eng 17(1):1-13, 1979); (2) Bijker (Mechanics of sediment transport by the combination of waves and current. In: Design and reliability of coastal structures. 23rd international conference on Coastal Engineering, pp 147-173, 1968) and (3) Soulsby (Dynamics of Marine Sands. A manual for practical applications. HR Wallingford, Wallingford, p 142, 1997) modified version of van Rijn [J Hydraul Eng 110(10):1431-1456, 1984a, J Hydraul Eng 110(11):1613-1641, 1984b] formulation. Both a qualitative (i.e. visual comparison) and a quantitative tool [Brier Skill Score (BSS); described in Sutherland et al. in Coast Eng 51:917-939, 2004b] are applied to assess the similarity of simulations when compared to model predictions and observations. Tests confirmed the reliability and time efficiency of the ensemble technique, since it reproduced very well the results of a reference run, a computation based on the observed boundary conditions. For the spring-neap cycle modelled, the BSS was of 0.91 (a perfect modelling would have a BSS of 1), with a reduction in the simulation time on the order of 80%. For the 6-month-period simulation, results were also excellent: BSS=0.92 and a computer time reduction of 85%. In principle, this method has the advantage of being applied to any process-based numerical model.

  2. Prognostic value of endoglin-assessed microvessel density in cancer patients: a systematic review and meta-analysis

    PubMed Central

    Zhang, Jinguo; Zhang, Lingyun; Lin, Qunbo; Ren, Weimin; Xu, Guoxiong

    2018-01-01

    Background Endoglin (ENG, CD105), an auxiliary receptor for several TGF-β superfamily ligands, is constitutively expressed in tumor microvessels. The prognostic value of ENG-assessed microvessel density (MVD) has not been systemically analyzed. This meta-analysis reviews and evaluates the association between ENG expression and prognosis in cancer patients. Materials and Methods Thirty published studies involving in 3613 patients were included after searching of PubMed, Web of Science, and EMBASE. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) were calculated using random-effects models. The publication bias was detected by a Begg’s test and Egger’s test. The outcome stability was verified by sensitivity analysis. Results The high ENG-assessed MVD was significantly associated with poor OS (HR = 2.14, 95% CI 1.62–2.81; P < 0.001), DFS (HR = 3.23, 95% CI 2.10–4.95; P < 0.001), CSS (HR = 3.33, 95% CI 1.32–8.37; P < 0.001). Furthermore, subgroup analysis revealed that the association between the overexpression of ENG in tumor microvessels and the outcome endpoints (OS or DFS) were also significant in the Asians and Caucasians patients with different cancer types. Conclusions ENG of tumor microvessels is a predictor of poor OS, DFS and CSS and may be a prognostic marker of patients with cancer. PMID:29484142

  3. Bibliography on Cold Regions Science and Technology. Volume 52. Part 2,

    DTIC Science & Technology

    1998-12-01

    eng] 52-5087 spheric gases from antarctic ice cores. Gillaik, T., et al, in sediments and biota from four US arctic lakes. Allen-Gil, Study of the...1996,eng] 52-2678 52-690 Solomon , S., et at, [1997,eng] 52-879 Studies of cloud ice water path and optical thickness during Homogeneous ice...of clouds: a wave ota, D., et al, [1995,eng] 52-5364 flash rate. Solomon , R.C., [1997,eng] 52-1070 cloud case study . Ackerman, S.A., et al, [1998,eng

  4. Extended use up to 5 years of the etonogestrel-releasing subdermal contraceptive implant: comparison to levonorgestrel-releasing subdermal implant

    PubMed Central

    Ali, Moazzam; Akin, Ayse; Bahamondes, Luis; Brache, Vivian; Habib, Ndema; Landoulsi, Sihem; Hubacher, David

    2016-01-01

    STUDY QUESTION Is it possible to extend the use of the 3-year one-rod etonogestrel (ENG)-releasing subdermal contraceptive implant to 5 years? SUMMARY ANSWER The extended use of the one-rod ENG-releasing subdermal contraceptive implant showed 100% efficacy in years 4 and 5. WHAT IS KNOWN ALREADY The initial regulated trials on the ENG-releasing subdermal contraceptive implant conducted in the 1990 s were designed to measure cumulative 3-year efficacy. The ENG-implant has both well established safety and efficacy for up to 3 years. Pharmacokinetic data on ENG show high levels at 3 years and some previous clinical research confirms efficacy beyond the current approved duration of 3 years. Today, many women, because the labeled duration has been reached, have the ENG implant removed at 3 years, increasing costs, inconvenience and risks. STUDY DESIGN SIZE, DURATION For the first 3 years, this study was an open-label, multi-centre randomized trial comparing the 3-year ENG implant to the 5-year levonorgestrel (LNG)-releasing implant. After 3 years, a subset of 390 ENG participants, consented to extended use. We compared efficacy, side effects and removal procedures of both implants. We used Kaplan–Meier (K–M) analysis. We included an observational cohort of copper intrauterine device (IUD) users as non-users of hormonal contraceptive method for comparative purposes. PARTICIPANTS/MATERIALS, SETTING, METHODS The study took place in family planning clinics in seven countries worldwide. Women were enlisted after an eligibility check and informed consent, and 1328 women were enrolled: 390, 522 and 416 in the ENG-implant, LNG-implant and IUD groups, respectively. MAIN RESULTS AND THE ROLE OF CHANCE Over 200 women used the ENG implant for at least 5 years. No pregnancies occurred during the additional 2 years of follow up in the ENG or LNG implant group. The overall 5-year K–M cumulative pregnancy rates for ENG- and LNG- implants were 0.6 per 100 women-years (W-Y) [95% confidence interval (CI): 0.2–1.8] and 0.8 per 100 W-Y [95% CI: 0.2–2.3], respectively. Complaints of bleeding changes were similar; however, ENG-users were more likely than LNG-users to experience heavy bleeding (p < 0.05). The median duration of the implant removal procedure was 64 seconds shorter for the one-rod ENG-implant (inter-quartile range (IQR) = 30.5, 117.5) compared to the two-rod LNG product (IQR = 77.0, 180.0). The 2-year rate for pregnancy in the IUD group compared with the two implant groups combined was 4.1 per 100 W-Y [95% CI: 2.5–6.5]. LIMITATIONS, REASONS FOR CAUTION Few women were ≤19 years old or nulligravida. Although there was no weight limit for enrolment in the study, the number of women ≥70 kg were few. WIDER IMPLICATIONS OF THE FINDINGS The results from this study corroborate previous evidence showing high contraceptive efficacy through 4 years for the ENG-implant. Data through 5 years are a novel contribution and further proof of the product's capability to provide safe and effective contraception that rivals the current 5-year LNG-subdermal implant. The findings provide valuable information for policy makers, family planning programmers and clinicians that the ENG-releasing subdermal implant is still highly effective up to 5 years after insertion. Compared to previous efforts, our study population was geographically diverse and our study had the highest number of participants completing at least 5 years of use. TRIAL REGISTRATION The trial was registered as ISRCTN33378571. STUDY FUNDING/COMPETING INTEREST(S) The contraceptive devices and funds for conduct of the study were provided by the United Nations Development Programme/United Nations Population Fund/World Health Organization (WHO)/UNICEF/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research (RHR), WHO. This report contains the collective views of an international group of experts, and does not necessarily represent the decisions or the stated policy of the WHO. All stated authors have no conflict of interest, except Dr Hubacher who reported grants from United States Agency for International Development, during the conduct of the study; other from Advisory Boards (Teva, Bayer, OCON), outside the submitted work. PMID:27671673

  5. High-Performance Parallel Analysis of Coupled Problems for Aircraft Propulsion

    NASA Technical Reports Server (NTRS)

    Felippa, C. A.; Farhat, C.; Park, K. C.; Gumaste, U.; Chen, P.-S.; Lesoinne, M.; Stern, P.

    1997-01-01

    Applications are described of high-performance computing methods to the numerical simulation of complete jet engines. The methodology focuses on the partitioned analysis of the interaction of the gas flow with a flexible structure and with the fluid mesh motion driven by structural displacements. The latter is treated by a ALE technique that models the fluid mesh motion as that of a fictitious mechanical network laid along the edges of near-field elements. New partitioned analysis procedures to treat this coupled three-component problem were developed. These procedures involved delayed corrections and subcycling, and have been successfully tested on several massively parallel computers, including the iPSC-860, Paragon XP/S and the IBM SP2. The NASA-sponsored ENG10 program was used for the global steady state analysis of the whole engine. This program uses a regular FV-multiblock-grid discretization in conjunction with circumferential averaging to include effects of blade forces, loss, combustor heat addition, blockage, bleeds and convective mixing. A load-balancing preprocessor for parallel versions of ENG10 was developed as well as the capability for the first full 3D aeroelastic simulation of a multirow engine stage. This capability was tested on the IBM SP2 parallel supercomputer at NASA Ames.

  6. Facilitation of endoglin-targeting cancer therapy by development/utilization of a novel genetically engineered mouse model expressing humanized endoglin (CD105).

    PubMed

    Toi, Hirofumi; Tsujie, Masanori; Haruta, Yuro; Fujita, Kanako; Duzen, Jill; Seon, Ben K

    2015-01-15

    Endoglin (ENG) is a TGF-β coreceptor and essential for vascular development and angiogenesis. A chimeric antihuman ENG (hENG) monoclonal antibody (mAb) c-SN6j (also known as TRC105) shows promising safety and clinical efficacy features in multiple clinical trials of patients with various advanced solid tumors. Here we developed a novel genetically engineered mouse model to optimize the ENG-targeting clinical trials. We designed a new targeting vector that contains exons 4-8 of hENG gene to generate novel genetically engineered mice (GEMs) expressing functional human/mouse chimeric (humanized) ENG with desired epitopes. Genotyping of the generated mice confirmed that we generated the desired GEMs. Immunohistochemical analysis demonstrated that humanized ENG protein of the GEMs expresses epitopes defined by 7 of our 8 anti-hENG mAbs tested. Surprisingly the homozygous GEMs develop normally and are healthy. Established breast and colon tumors as well as metastasis and tumor microvessels in the GEMs were effectively suppressed by systemic administration of anti-hENG mAbs. Additionally, test result indicates that synergistic potentiation of antitumor efficacy can be induced by simultaneous targeting of two distinct epitopes by anti-hENG mAbs. Sorafenib and capecitabine also showed antitumor efficacy in the GEMs. The presented novel GEMs are the first GEMs that express the targetable humanized ENG. Test results indicate utility of the GEMs for the clinically relevant studies. Additionally, we generated GEMs expressing a different humanized ENG containing exons 5-6 of hENG gene, and the homozygous GEMs develop normally and are healthy. © 2014 UICC.

  7. Pulse Coupled Neural Networks for the Segmentation of Magnetic Resonance Brain Images.

    DTIC Science & Technology

    1996-12-01

    PULSE COUPLED NEURAL NETWORKS FOR THE SEGMENTATION OF MAGNETIC RESONANCE BRAIN IMAGES THESIS Shane Lee Abrahamson First Lieutenant, USAF AFIT/GCS/ENG...COUPLED NEURAL NETWORKS FOR THE SEGMENTATION OF MAGNETIC RESONANCE BRAIN IMAGES THESIS Shane Lee Abrahamson First Lieutenant, USAF AFIT/GCS/ENG/96D-01...research develops an automated method for segmenting Magnetic Resonance (MR) brain images based on Pulse Coupled Neural Networks (PCNN). MR brain image

  8. Proceedings of oceans 87. The ocean - an international workplace

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1987-01-01

    This book includes proceedings containing 347 papers. Some of the topics are: ICE -Cold ocean and ice research; ICE-1-Icebergs; ICE-2-Sea ice and structures; IE-3-Cold ocean instrumentation; ICE-4-Ocean and ice; INS-Oceanographic instrumentation; INS-1-Acoustic Doppler Current profilers; ENG-1-New solutions to old problems; ENG-2-energy from the ocean; ENG-3-Cables and connectors; POL-Policy, education and technology transfer; POL-1-International issues; POL-2-Ocean space utilization; POL-3-Economics, planning and management; SCI-6-fish stock assessment; ACI-7-Coastal currents and sediment; SCI-9-Satellite navigation; SCI-10-Deep sea minerals and methods of recovery; ODS-Fifth working symposium on oceanographic data system; ODS-1-Data base management; UND-Underwater work systems; UND-1-Diving for science.

  9. An Adaptive Method for Scheduling the Sequence and Route of Builder Trials for a New Ship

    DTIC Science & Technology

    2015-09-01

    EML ’, ’SPD’, ’ZZ1’, ’UWN’, ’CS1’, ’IN1’, ’AIS’, ’INC’, ’ECD’, ’CBT’, ’FCS’, ’CWS’, ’GUN’, ’OAV’, ’CRA...37, 2), 77) EML ((35, 24), 7) AMV** ((21, 5), 81) HFE ((22, 17), 60) MTR ((13, 16), 54) SPD ((36, 25), 7) AMV** ((11, 5), 105) MSB ((17, 17), 79) NTX...Log EML 45 30 GY2; ENG; RDR 15 0.65 0.13 1 1 46 zigzag ZZ1 45 50 GY2; ENG; RDR; SPD 20 0.65 0.13 2 2 Turning Circle TC1 30 50 RDR; GY2; ENG; SPD

  10. Annual Report for 1990: Laboratory Graduate Fellowship Program

    DTIC Science & Technology

    1991-04-30

    Statitiocs of feasureeint~ ad Sam- the qitadrature approximation of the axial pluvg. 700 pp.. American Society of Agronomy, Madison . Wis.. integral...numerical solutions for solid diffusion in fixed Amewrican Society of Agronomy. Madison . Wis., 190%6. beds. hId. Eng. Chem.. 46(g). 1590-1594. 1954...Department of Engineering Professional Development, University of Wisconsin- Madison , Madison , Wisconsin, September 20-21, 1989. "Review of Soil Vapor

  11. Extended use up to 5 years of the etonogestrel-releasing subdermal contraceptive implant: comparison to levonorgestrel-releasing subdermal implant.

    PubMed

    Ali, Moazzam; Akin, Ayse; Bahamondes, Luis; Brache, Vivian; Habib, Ndema; Landoulsi, Sihem; Hubacher, David

    2016-11-01

    Is it possible to extend the use of the 3-year one-rod etonogestrel (ENG)-releasing subdermal contraceptive implant to 5 years? The extended use of the one-rod ENG-releasing subdermal contraceptive implant showed 100% efficacy in years 4 and 5. The initial regulated trials on the ENG-releasing subdermal contraceptive implant conducted in the 1990 s were designed to measure cumulative 3-year efficacy. The ENG-implant has both well established safety and efficacy for up to 3 years. Pharmacokinetic data on ENG show high levels at 3 years and some previous clinical research confirms efficacy beyond the current approved duration of 3 years. Today, many women, because the labeled duration has been reached, have the ENG implant removed at 3 years, increasing costs, inconvenience and risks. For the first 3 years, this study was an open-label, multi-centre randomized trial comparing the 3-year ENG implant to the 5-year levonorgestrel (LNG)-releasing implant. After 3 years, a subset of 390 ENG participants, consented to extended use. We compared efficacy, side effects and removal procedures of both implants. We used Kaplan-Meier (K-M) analysis. We included an observational cohort of copper intrauterine device (IUD) users as non-users of hormonal contraceptive method for comparative purposes. The study took place in family planning clinics in seven countries worldwide. Women were enlisted after an eligibility check and informed consent, and 1328 women were enrolled: 390, 522 and 416 in the ENG-implant, LNG-implant and IUD groups, respectively. Over 200 women used the ENG implant for at least 5 years. No pregnancies occurred during the additional 2 years of follow up in the ENG or LNG implant group. The overall 5-year K-M cumulative pregnancy rates for ENG- and LNG- implants were 0.6 per 100 women-years (W-Y) [95% confidence interval (CI): 0.2-1.8] and 0.8 per 100 W-Y [95% CI: 0.2-2.3], respectively. Complaints of bleeding changes were similar; however, ENG-users were more likely than LNG-users to experience heavy bleeding (p < 0.05). The median duration of the implant removal procedure was 64 seconds shorter for the one-rod ENG-implant (inter-quartile range (IQR) = 30.5, 117.5) compared to the two-rod LNG product (IQR = 77.0, 180.0). The 2-year rate for pregnancy in the IUD group compared with the two implant groups combined was 4.1 per 100 W-Y [95% CI: 2.5-6.5]. Few women were ≤19 years old or nulligravida. Although there was no weight limit for enrolment in the study, the number of women ≥70 kg were few. The results from this study corroborate previous evidence showing high contraceptive efficacy through 4 years for the ENG-implant. Data through 5 years are a novel contribution and further proof of the product's capability to provide safe and effective contraception that rivals the current 5-year LNG-subdermal implant. The findings provide valuable information for policy makers, family planning programmers and clinicians that the ENG-releasing subdermal implant is still highly effective up to 5 years after insertion. Compared to previous efforts, our study population was geographically diverse and our study had the highest number of participants completing at least 5 years of use. The trial was registered as ISRCTN33378571. The contraceptive devices and funds for conduct of the study were provided by the United Nations Development Programme/United Nations Population Fund/World Health Organization (WHO)/UNICEF/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research (RHR), WHO. This report contains the collective views of an international group of experts, and does not necessarily represent the decisions or the stated policy of the WHO. All stated authors have no conflict of interest, except Dr Hubacher who reported grants from United States Agency for International Development, during the conduct of the study; other from Advisory Boards (Teva, Bayer, OCON), outside the submitted work. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.

  12. Automation of the Reporting and Tracking Requirements of Architect-Engineering Type Contracts.

    DTIC Science & Technology

    1984-09-01

    Electrical Eng 03 Oceano rahers 04 -- 10 Architect 05 Estimatcrs 06-- Urban Planners 07 Chemical Eng 08 -- Geologists 09--3 Sanitary Eng 10 -25 Civil Eng...geographic dispersicn of the activities, cc:tzal centers for information exchange should L idert iEd (newsletters, regional periodic meetizgs, sol r

  13. Plane stress problems using hysteretic rigid body spring network models

    NASA Astrophysics Data System (ADS)

    Christos, Sofianos D.; Vlasis, Koumousis K.

    2017-10-01

    In this work, a discrete numerical scheme is presented capable of modeling the hysteretic behavior of 2D structures. Rigid Body Spring Network (RBSN) models that were first proposed by Kawai (Nucl Eng Des 48(1):29-207, 1978) are extended to account for hysteretic elastoplastic behavior. Discretization is based on Voronoi tessellation, as proposed specifically for RBSN models to ensure uniformity. As a result, the structure is discretized into convex polygons that form the discrete rigid bodies of the model. These are connected with three zero length, i.e., single-node springs in the middle of their common facets. The springs follow the smooth hysteretic Bouc-Wen model which efficiently incorporates classical plasticity with no direct reference to a yield surface. Numerical results for both static and dynamic loadings are presented, which validate the proposed simplified spring-mass formulation. In addition, they verify the model's applicability on determining primarily the displacement field and plastic zones compared to the standard elastoplastic finite element method.

  14. The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure

    PubMed Central

    Garfoot, Andrew L.; Shen, Qian; Wüthrich, Marcel; Klein, Bruce S.

    2016-01-01

    ABSTRACT The fungal pathogen Histoplasma capsulatum parasitizes host phagocytes. To avoid antimicrobial immune responses, Histoplasma yeasts must minimize their detection by host receptors while simultaneously interacting with the phagocyte. Pathogenic Histoplasma yeast cells, but not avirulent mycelial cells, secrete the Eng1 protein, which is a member of the glycosylhydrolase 81 (GH81) family. We show that Histoplasma Eng1 is a glucanase that hydrolyzes β-(1,3)-glycosyl linkages but is not required for Histoplasma growth in vitro or for cell separation. However, Histoplasma yeasts lacking Eng1 function have attenuated virulence in vivo, particularly during the cell-mediated immunity stage. Histoplasma yeasts deficient for Eng1 show increased exposure of cell wall β-glucans, which results in enhanced binding to the Dectin-1 β-glucan receptor. Consistent with this, Eng1-deficient yeasts trigger increased tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) cytokine production from macrophages and dendritic cells. While not responsible for large-scale cell wall structure and function, the secreted Eng1 reduces levels of exposed β-glucans at the yeast cell wall, thereby diminishing potential recognition by Dectin-1 and proinflammatory cytokine production by phagocytes. In α-glucan-producing Histoplasma strains, Eng1 acts in concert with α-glucan to minimize β-glucan exposure: α-glucan provides a masking function by covering the β-glucan-rich cell wall, while Eng1 removes any remaining exposed β-glucans. Thus, Histoplasma Eng1 has evolved a specialized pathogenesis function to remove exposed β-glucans, thereby enhancing the ability of yeasts to escape detection by host phagocytes. PMID:27094334

  15. Physical Model Study of Cross Vanes and Ice

    DTIC Science & Technology

    2009-08-01

    spacing since, in the pre-scour state, experiments and the HEC - RAS hydraulic model (USACE 2002b) found that water surface ele- vation merged with the...docs/eng-manuals/em1110- 2-1612/toc.htm. USACE (2002b) HEC - RAS , Hydraulic Reference Manual. US Army Corps of Engineers Hydrologic Engineering Center...Currently little design guidance is available for constructing these structures on ice-affected rivers . This study used physical and numerical

  16. Micromorphic approach for gradient-extended thermo-elastic-plastic solids in the logarithmic strain space

    NASA Astrophysics Data System (ADS)

    Aldakheel, Fadi

    2017-11-01

    The coupled thermo-mechanical strain gradient plasticity theory that accounts for microstructure-based size effects is outlined within this work. It extends the recent work of Miehe et al. (Comput Methods Appl Mech Eng 268:704-734, 2014) to account for thermal effects at finite strains. From the computational viewpoint, the finite element design of the coupled problem is not straightforward and requires additional strategies due to the difficulties near the elastic-plastic boundaries. To simplify the finite element formulation, we extend it toward the micromorphic approach to gradient thermo-plasticity model in the logarithmic strain space. The key point is the introduction of dual local-global field variables via a penalty method, where only the global fields are restricted by boundary conditions. Hence, the problem of restricting the gradient variable to the plastic domain is relaxed, which makes the formulation very attractive for finite element implementation as discussed in Forest (J Eng Mech 135:117-131, 2009) and Miehe et al. (Philos Trans R Soc A Math Phys Eng Sci 374:20150170, 2016).

  17. Generalized Fokker-Planck theory for electron and photon transport in biological tissues: application to radiotherapy.

    PubMed

    Olbrant, Edgar; Frank, Martin

    2010-12-01

    In this paper, we study a deterministic method for particle transport in biological tissues. The method is specifically developed for dose calculations in cancer therapy and for radiological imaging. Generalized Fokker-Planck (GFP) theory [Leakeas and Larsen, Nucl. Sci. Eng. 137 (2001), pp. 236-250] has been developed to improve the Fokker-Planck (FP) equation in cases where scattering is forward-peaked and where there is a sufficient amount of large-angle scattering. We compare grid-based numerical solutions to FP and GFP in realistic medical applications. First, electron dose calculations in heterogeneous parts of the human body are performed. Therefore, accurate electron scattering cross sections are included and their incorporation into our model is extensively described. Second, we solve GFP approximations of the radiative transport equation to investigate reflectance and transmittance of light in biological tissues. All results are compared with either Monte Carlo or discrete-ordinates transport solutions.

  18. Evaluation of Site Effects Using Numerical and Experimental Analyses In Cittas Di Castello (italy)

    NASA Astrophysics Data System (ADS)

    Pergalani, F.; de Franco, R.; Compagnoni, M.; Caielli, G.

    In the paper the results of the numerical and experimental analyses, in a site of the Umbria Region (Città di Castello - PG), finalized to the evaluations of site effects are shown. The aim of the work was to compare the two type of analyses, to give some methodologies that may be used at the level of urban planning, to consider these as- pects. Therefore a series of geologic, geomorphologic (1:5.000 scale), geotechnic and seismic analyses have been carried out, to identify the areas affected to local effects and to characterize the lithotechnic units. The expected seismic inputs are been indi- viduated and 2D (Quad4M, Hudson et al., 1993) numerical analyses have been done. An experimental analysis, using the registrations of small events, has been done. The results, for the two approaches, were performed in terms of elastic pseudo-acceleration spectra and amplification factors, as a ratio between spectral intensity (Housner, 1952), calculated using the pseudo-velocity spectra, in the periods of 0.1-0.5 s and 0.1-2.5 s of output and input. The results have been analyzed and compared, to give a method- ology that may be exhaustive and precise. The conclusions can be summarized in the following points: u° the results of the two approaches are coherent; u° the differences between the two approaches are: the use of the numerical analysis is easy and quick but, in this case, the use of 2D analysis produces a simplification of real geometry; the use of experimental analysis allows to consider the 3D conditions, but, in this case, the registrations of events characterized by low energy, do not allow to consider the non linear behavior of materials, moreover it is necessary to perform the registrations for a period depending from the seismicity of the region (1 month - two years); u° the possi- bility of integration of the two methodologies allows to perform a complete analysis, using the advantages of the two methods. Housner G.W., Spectrum Intensities of strong motion earthquakes. Proc. of the Symp. on Earth. and Blast Effects on Structures. Earth. Eng. Res. Inst., 1952. Hudson M.B., Idriss I.M., Beikae M. QUAD4M, A computer program for evaluating the seismic response of soil structure by variable damping finite element procedures. Report of Dip. of Civil & Env. Eng., University of California, Davis, 1993.

  19. EDITORIAL: Special section on gaze-independent brain-computer interfaces Special section on gaze-independent brain-computer interfaces

    NASA Astrophysics Data System (ADS)

    Treder, Matthias S.

    2012-08-01

    Restoring the ability to communicate and interact with the environment in patients with severe motor disabilities is a vision that has been the main catalyst of early brain-computer interface (BCI) research. The past decade has brought a diversification of the field. BCIs have been examined as a tool for motor rehabilitation and their benefit in non-medical applications such as mental-state monitoring for improved human-computer interaction and gaming has been confirmed. At the same time, the weaknesses of some approaches have been pointed out. One of these weaknesses is gaze-dependence, that is, the requirement that the user of a BCI system voluntarily directs his or her eye gaze towards a visual target in order to efficiently operate a BCI. This not only contradicts the main doctrine of BCI research, namely that BCIs should be independent of muscle activity, but it can also limit its real-world applicability both in clinical and non-medical settings. It is only in a scenario devoid of any motor activity that a BCI solution is without alternative. Gaze-dependencies have surfaced at two different points in the BCI loop. Firstly, a BCI that relies on visual stimulation may require users to fixate on the target location. Secondly, feedback is often presented visually, which implies that the user may have to move his or her eyes in order to perceive the feedback. This special section was borne out of a BCI workshop on gaze-independent BCIs held at the 2011 Society for Applied Neurosciences (SAN) Conference and has then been extended with additional contributions from other research groups. It compiles experimental and methodological work that aims toward gaze-independent communication and mental-state monitoring. Riccio et al review the current state-of-the-art in research on gaze-independent BCIs [1]. Van der Waal et al present a tactile speller that builds on the stimulation of the fingers of the right and left hand [2]. H¨ohne et al analyze the ergonomic aspects of stimuli and systematic class confusions in auditory BCIs [3]. Andersson et al use fMRI for online-decoding of covert shifts of visual attention [4]. Thurlings et al show that multi-sensory integration of tactile and visual information can enhance the amplitude of ERP components [5]. Schaeff et al investigate the use of motion VEPs in gaze-independent visual BCIs [6]. Wilson et al substitute visual feedback by mapping the screen's cursor onto a tactor grid that stimulates the tongue [7]. Brouwer et al explore the use of ERP features and spectral features for estimating mental workload in an n-back task [8]. Falzon et al extend the Common Spatial Patterns (CSP) method to the complex plane, taking into account both amplitude and phase relationships [9]. Eliseyev et al present a method for the sparse sub-selection of electrodes for classification [10]. Tonin et al demonstrate that the classification of covert attention shifts is improved by considering sub-bands of the alpha band [11]. Aloise et al investigate effects of classification scheme and decimation on the performance of a gaze-independent BCI [12]. References [1] Riccio A et al 2012 J. Neural Eng. 9 045001 [2] van der Waal M et al 2012 J. Neural Eng. 9 045002 [3] Höhne J et al 2012 J. Neural Eng. 9 045003 [4] Andersson P et al 2012 J. Neural Eng. 9 045004 [5] Thurlings M E et al 2012 J. Neural Eng. 9 045005 [6] Schaeff S et al 2012 J. Neural Eng. 9 045006 [7] Wilson J A et al 2012 J. Neural Eng. 9 045007 [8] Brouwer A-M et al 2012 J. Neural Eng. 9 045008 [9] Falzon O et al 2012 J. Neural Eng. 9 045009 [10] Eliseyev A et al 2012 J. Neural Eng. 9 045010 [11] Tonin L et al 2012 J. Neural Eng. 9 045011 [12] Aloise F et al 2012 J. Neural Eng. 9 045012

  20. JPRS Report, Science & Technology, Japan, 1987 S&T Paper

    DTIC Science & Technology

    1988-08-26

    council recommended in its report increasing the amount of subsidies for scientific research, vitalizing the scientific research systems at...activities that have recently been progressing in Japan. Greatest importance was attached to "the development of an effective means of preventing cancer...natter COKPENDEX (Engineering —Civil enginsering, environmental eng, —Hetal, resource eng —Hechanical eng. —ChBnical, agric . eng —Agricultural, nana

  1. Quantifying Variations In Multi-parameter Models With The Photon Clean Method (PCM) And Bootstrap Methods

    NASA Astrophysics Data System (ADS)

    Carpenter, Matthew H.; Jernigan, J. G.

    2007-05-01

    We present examples of an analysis progression consisting of a synthesis of the Photon Clean Method (Carpenter, Jernigan, Brown, Beiersdorfer 2007) and bootstrap methods to quantify errors and variations in many-parameter models. The Photon Clean Method (PCM) works well for model spaces with large numbers of parameters proportional to the number of photons, therefore a Monte Carlo paradigm is a natural numerical approach. Consequently, PCM, an "inverse Monte-Carlo" method, requires a new approach for quantifying errors as compared to common analysis methods for fitting models of low dimensionality. This presentation will explore the methodology and presentation of analysis results derived from a variety of public data sets, including observations with XMM-Newton, Chandra, and other NASA missions. Special attention is given to the visualization of both data and models including dynamic interactive presentations. This work was performed under the auspices of the Department of Energy under contract No. W-7405-Eng-48. We thank Peter Beiersdorfer and Greg Brown for their support of this technical portion of a larger program related to science with the LLNL EBIT program.

  2. Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglin.

    PubMed

    Wipff, J; Avouac, J; Borderie, D; Zerkak, D; Lemarechal, H; Kahan, A; Boileau, C; Allanore, Y

    2008-07-01

    SSc is a CTD characterized by early generalized microangiopathy with disturbed angiogenesis. Soluble endoglin (sENG), a serum anti-angiogenic protein, has recently been described as a major actor in pre-eclampsia, another severe vascular disease with abnormal angiogenesis. The aim of this study was to investigate, in a cross-sectional study, sENG levels together with other serum vascular markers. Serum levels of sENG were assessed by ELISA in consecutive SSc patients and controls matched for age and sex. We also measured by ELISA serum levels of VEGF and asymmetric dimethylarginine (ADMA), as respective markers of angiogenesis and endothelial dysfunction. We included 235 unrelated subjects: 187 SSc patients and 48 controls. Higher concentrations of sENG (P = 0.002) and sVEGF (P < 0.0001) were found in SSc patients compared with controls whereas there was no difference for ADMA. In multivariate analysis, sENG levels were significantly increased in SSc patients with cutaneous ulcerations (P = 0.0003), positive for ACAs (P = 0.009) and with abnormal diffusing capacity for carbon monoxide divided by alveolar volume (P = 0.03). Soluble ENG levels negatively correlated with ADMA, but no relationship was found between sENG and sVEGF. This study shows increased values of sENG in a large SSc cohort and a relevant association with a vascular phenotype. The predictive value of the biomarker sENG and its potential role on cellular endothelial disturbances remain to be determined.

  3. A Rigorous Sharp Interface Limit of a Diffuse Interface Model Related to Tumor Growth

    NASA Astrophysics Data System (ADS)

    Rocca, Elisabetta; Scala, Riccardo

    2017-06-01

    In this paper, we study the rigorous sharp interface limit of a diffuse interface model related to the dynamics of tumor growth, when a parameter ɛ, representing the interface thickness between the tumorous and non-tumorous cells, tends to zero. More in particular, we analyze here a gradient-flow-type model arising from a modification of the recently introduced model for tumor growth dynamics in Hawkins-Daruud et al. (Int J Numer Math Biomed Eng 28:3-24, 2011) (cf. also Hilhorst et al. Math Models Methods Appl Sci 25:1011-1043, 2015). Exploiting the techniques related to both gradient flows and gamma convergence, we recover a condition on the interface Γ relating the chemical and double-well potentials, the mean curvature, and the normal velocity.

  4. The Association Between Vestibular Physical Examination, Vertigo Questionnaires, and the Electronystagmography in Patients With Vestibular Symptoms.

    PubMed

    Gofrit, Shany G; Mayler, Yulia; Eliashar, Ron; Bdolah-Abram, Tali; Ilan, Ophir; Gross, Menachem

    2017-04-01

    Dizziness makes up a diagnostic and treatment challenge. The diagnostic accuracy of the medical history and vestibular physical examination in cases of vestibular symptoms is not clear. The aim of this study is to determine the association between vestibular physical examination, vestibular questionnaires, and electronystagmography (ENG) test in patients with vestibular symptoms. This is a prospective study of 135 adults with vestibular symptoms. The subjects underwent targeted physical examination and filled vestibular questionnaires, including the Dizziness Handicap Inventory (DHI), before ENG testing. The results of the physical examination and questionnaires were compared with the final ENG findings. Of patients who had normal ENG results, 32.1% (17/52) showed abnormal physical examination, and 48.8% (40/82) of the patient who had normal physical examination showed abnormal ENG results ( P = .46). Among patients with severe disability by DHI, 46.4% (13/28) had an abnormal ENG, and 42.9% (12/28) had a normal ENG ( P = .39). This study did not demonstrate association between vestibular physical examination, vestibular questionnaires, and ENG results. Although history (augmented by questionnaires) and physical examination are the initial steps in the evaluation of vertigo, the current study suggests that they should be complemented by objective testing for evaluation of inner ear origin of vertigo.

  5. An efficient technique for the numerical solution of the bidomain equations.

    PubMed

    Whiteley, Jonathan P

    2008-08-01

    Computing the numerical solution of the bidomain equations is widely accepted to be a significant computational challenge. In this study we extend a previously published semi-implicit numerical scheme with good stability properties that has been used to solve the bidomain equations (Whiteley, J.P. IEEE Trans. Biomed. Eng. 53:2139-2147, 2006). A new, efficient numerical scheme is developed which utilizes the observation that the only component of the ionic current that must be calculated on a fine spatial mesh and updated frequently is the fast sodium current. Other components of the ionic current may be calculated on a coarser mesh and updated less frequently, and then interpolated onto the finer mesh. Use of this technique to calculate the transmembrane potential and extracellular potential induces very little error in the solution. For the simulations presented in this study an increase in computational efficiency of over two orders of magnitude over standard numerical techniques is obtained.

  6. A pepper mottle virus-based vector enables systemic expression of endoglucanase D in non-transgenic plants.

    PubMed

    Song, Eun Gyeong; Ryu, Ki Hyun

    2017-12-01

    Plant-virus-based expression vectors have been used as an alternative to the creation of transgenic plants. Using a virus-based vector, we investigated the feasibility of producing the endoglucanase D (EngD) from Clostridium cellulovorans in Nicotiana benthamiana. This protein has endoglucanase, xylanase, and exoglucanase activities and may be of value for cellulose digestion in the generation of biofuels from plant biomass. The EngD gene was cloned between the nuclear inclusion b (NIb)- and coat protein (CP)-encoding sequences of pSP6PepMoV-Vb1. In vitro transcripts derived from the clone (pSP6PepMoV-Vb1/EngD) were infectious in N. benthamiana but caused milder symptoms than wild-type PepMoV-Vb1. RT-PCR amplification of total RNA from non-inoculated upper leaves infected with PepMoV-Vb1/EngD produced the target band for the CP, partial NIb and EngD-CP regions of PepMoV-V1/EngD, in addition to nonspecific bands. Western blot analysis showed the CP target bands of PepMoV-Vb1/EngD as well as non-target bands. EngD enzymatic activity in infected plants was detected using a glucose assay. The plant leaves showed increased senescence compared with healthy and PepMoV-Vb1-infected plants. Our study suggests the feasibility of using a viral vector for systemic infection of plants for expression of heterologous engD for the purpose of digesting a cellulose substrate in plant cells for biomass production.

  7. Decreased Endoglin expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia rat model.

    PubMed

    Zimmer, Julia; Takahashi, Toshiaki; Hofmann, Alejandro D; Puri, Prem

    2017-02-01

    Pulmonary hypertension (PH) remains a therapeutical challenge in neonates born with congenital diaphragmatic hernia (CDH). Endoglin (Eng), an auxiliary receptor component of the transforming growth factor β (TGFβ) signalling pathway, is expressed mainly by endothelial cells and has been found to be involved in angiogenesis and vascular remodelling. Genetic studies have linked TGFβ and Eng mutations to human arterial PH and other cardiovascular syndromes. Eng interacts with the TGFβ receptors 1 and 2 (Tgfβr1, Tgfβr2). We designed this study to investigate the hypothesis that Eng is altered in the pulmonary vasculature of rats with nitrofen-induced CDH subjected to its interdependency with Tgfβr1 and Tgfβr2. After ethical approval (Rec 913b), time-pregnant Sprague-Dawley rats received either nitrofen or olive oil on gestational day (D9). The foetuses (n = 22) were sacrificed and divided into CDH and control group on D21. Gene and protein expressions of Eng, Tgfβr1 and Tgfβr2 were assessed via qRT-PCR and western blotting. Immunofluorescence staining for Eng was combined with CD34 to evaluate Eng expression in the pulmonary vasculature. Relative mRNA levels of Eng, Tgfβr1 and Tgfβr2 were significantly downregulated in CDH lungs compared to controls (Eng CDH 0.341 ± 0.022, Eng Ctrl 0.471 ± 0.031, p = 0.0015; Tgfβr1 CDH 0.161 ± 0.008, Tgfβr1 Ctrl 0.194 ± 0.01, p = 0.0114; Tgfβr2 CDH 0.896 ± 0.099, Tgfβr2 Ctrl 1.379 ± 0.081, p = 0.0006) Western blotting confirmed the reduced pulmonary protein expression of these three proteins in the CDH lungs. A markedly diminished endothelial expression of Eng in the pulmonary vasculature of nitrofen-exposed foetuses compared to controls was seen in laser scanning confocal-microscopy. This study demonstrates for the first time a reduced expression of Endoglin in the pulmonary vasculature of nitrofen-induced CDH. Abnormal Eng/Tgfβr1/Tgfβr2 signalling may contribute to impaired vascular remodelling and development of PH in this CDH animal model.

  8. SMC Systems Engineering: Specialty Engineering Disciplines Framework and Descriptions. Volume 2

    DTIC Science & Technology

    2011-10-03

    Engineering Disciplines Updale SNiEng Planning to Meet Program Objectives 1- -----:;..._- .-----------------, I Update SIW Eng T as1<s & Timing ol T asl<s...Analyses 1-Dev SNi Eng Products e.g. Assessmenls, Rills, Certs 1- ID & Manage Resources: Tools, Equip, Skills Assess Contractors’ Compian<:e to SIW Eng...Approaches to Meet SIW Ol>jeclives S1ipulale Contraclllal Risk and Actions lot Mitigations Review Contraclors’ Tech Data (Technical & Training Manuals

  9. 75 FR 56667 - Facilitating Shareholder Director Nominations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ... Company (``DuPont''); Eaton Corporation (``Eaton''); Michael Eng (``M. Eng''); FedEx Corporation (``FedEx... Corporation (``ExxonMobil''); FedEx; Financial Services Roundtable (``Financial Services Roundtable...; Cummins; Davis Polk; Dewey; DuPont; Eaton; M. Eng; FedEx; FMC Corp.; FPL Group; Frontier; GE; General...

  10. Classification of Acousto-Optic Correlation Signatures of Spread Spectrum Signals Using Artificial Neural Networks

    DTIC Science & Technology

    1989-12-01

    Ohio ’aPw iorlipuab muo i 0I2, AFIT/GE/ENG/89D-10 CLASSIFICATION OF ACOUSTO - OPTIC CORRELATION SIGNATURES OF SPREAD SPECTRUM SIGNALS USING ARTIFICIAL...ENG/89D- 10 CLASSIFICATION OF ACOUSTO - OPTIC CORRELATION SIGNATURES OF SPREAD SPECTRUM SIGNALS USING ARTIFICIAL NEURAL NETWORKS THESIS John W. DeBerry...Captain, USAF AFIT/GE/ENG/89D- 10 Approved for public release; distribution unlimited. AFIT/GE/ENG/89D-10 CLASSIFICATION OF ACOUSTO - OPTIC CORRELATION

  11. Bibliography on Cold Regions Science and Technology. Volume 40, Part 2, 1986

    DTIC Science & Technology

    1986-12-01

    affecting teabird oc- currence in the Scotia and Weddell Seaa [1984, |> 119-121, eng] 40-22« Ice edges and seabird occurrence in Antarctica [1^36...catclunent[1989, p.Ul-147, eng] 40-2411 Brl>tM,E. Obacrvatioiu of plankton organianu obtained by bongo ueta during the Nove nber-December 1983 ice-edge...p.293-312, eng] 40-2510 Characteristics of marine icing in Canadian waten [1989, p.78-94, eng] 40-2498 Climatology of severe storms affecting

  12. Polytype stability and defects in differently doped bulk SiC

    NASA Astrophysics Data System (ADS)

    Schmitt, Erwin; Straubinger, Thomas; Rasp, Michael; Vogel, Michael; Wohlfart, Andreas

    2008-03-01

    In this work, we present recent results on development and production of n-type 4 H bulk material. From previous studies it is evident that inclusions of foreign polytypes can act as origin of severe structural imperfections [N. Schulze, D.L. Barret, G. Pensl, S. Rohmfeld, M. Hundhausen, Mater. Sci. Eng. B 61-62 (1999) 44; D. Hofmann, E. Schmitt, M. Bickermann, M. Kölbl, P.J. Wellmann, A. Winnacker, Mater. Sci. Eng. B 61-62 (1999) 48], accompanied by defects like micropipes, stacking faults and dislocations. For that reason, we have carried out investigations to sustain polytype stability throughout the entire process, including nucleation and subsequent growth. Assisted by numerical calculations the influence of growth conditions, especially with respect to thermal field, Si/C ratio and doping, was examined. Several methods for the evaluation of material properties were applied to determine the quality most precisely, e.g. KOH-defect etching, optical microscopy, electron microscopy, X-ray diffraction and resistivity mapping. The key experience we gained was that moderate growth conditions with reduced temperature gradients are only one prerequisite for the reduction of defect density. Also stoichiometry in the gas phase and its modulation by nitrogen doping have to be taken into account and must be adjusted on the prevailing growth regime. We finally identified an optimized process that initiated a considerable improvement of material quality. Best values for 3″ 4 H wafers show that EPD<5×10 3 cm -2 and MPD<0.1 cm -2 can be achieved.

  13. Industrial & Manufacturing Engineering | Classification | College of

    Science.gov Websites

    Engineering(414)229-6597msahmed@uwm.eduEng & Math Sciences EMS W383 profile photo Dr. Onur AsanAdjunct Assistant ProfessorIndustrial & Manufacturing Engineeringoasan@mcw.eduEng & Math Sciences profile ChandlerAdjunct InstructorIndustrial & Manufacturing Engineeringchandlec@uwm.eduEng & Math Sciences

  14. The hydrophobic repeated domain of the Clostridium cellulovorans cellulose-binding protein (CbpA) has specific interactions with endoglucanases.

    PubMed Central

    Takagi, M; Hashida, S; Goldstein, M A; Doi, R H

    1993-01-01

    We overexpressed one of the hydrophobic repeated domains (HBDs) (110 amino acid residues) of the cellulose-binding protein (CbpA) from Clostridium cellulovorans by making a hybrid protein with the Escherichia coli maltose-binding protein (MalE). The HBD was purified to homogeneity, and interactions between the HBD and endoglucanases were analyzed by a novel interaction Western blotting (immunoblotting) method. The HBD had specific interactions with endoglucanases (EngB and EngD) from C. cellulovorans. These results indicated that the HBD was an endoglucanase binding site of CbpA. Images PMID:8226657

  15. Canadian Ranger Rifle: Human Factors Requirements Validation

    DTIC Science & Technology

    2010-08-01

    index-eng.asp retrieved 9 February 2010 2 http://www.armee.forces.gc.ca/land-terre/cr-rc/history- histoire -eng.asp retrieved 9 February 2010 3 http... histoire -eng.asp Department of National Defence. (2010). Canadian Ranger Patrol (CRPG). Retrieved June 3, 2010, from http://www.army.forces.gc.ca

  16. Abnormal computerized dynamic posturography findings in dizzy patients with normal ENG results.

    PubMed

    Sataloff, Robert T; Hawkshaw, Mary J; Mandel, Heidi; Zwislewski, Amy B; Armour, Jonathan; Mandel, Steven

    2005-04-01

    The complexities of the balance system create difficulties for professionals interested in testing equilibrium function objectively. Traditionally, electronystagmography (ENG) has been used for this purpose, but it provides information on only a limited portion of the equilibrium system. Computerized dynamic posturography (CDP) is less specific than ENG, but it provides more global insight into a patient's ability to maintain equilibrium under more challenging environmental circumstances. CD Palso appears to be valuable in obtaining objective confirmation of an abnormality in some dizzy patients whose ENG findings are normal. Our review of 33 patients with normal ENG results and abnormal CDP findings suggests that posturography is useful for confirming or quantifying a balance abnormality in some patients whose complaints cannot be confirmed by other tests frequently used by otologists.

  17. Numerical investigation of the effects of channel geometry on platelet activation and blood damage.

    PubMed

    Wu, Jingshu; Yun, B Min; Fallon, Anna M; Hanson, Stephen R; Aidun, Cyrus K; Yoganathan, Ajit P

    2011-02-01

    Thromboembolic complications in Bileaflet mechanical heart valves (BMHVs) are believed to be due to the combination of high shear stresses and large recirculation regions. Relating blood damage to design geometry is therefore essential to ultimately optimize the design of BMHVs. The aim of this research is to quantitatively study the effect of 3D channel geometry on shear-induced platelet activation and aggregation, and to choose an appropriate blood damage index (BDI) model for future numerical simulations. The simulations in this study use a recently developed lattice-Boltzmann with external boundary force (LBM-EBF) method [Wu, J., and C. K. Aidun. Int. J. Numer. Method Fluids 62(7):765-783, 2010; Wu, J., and C. K. Aidun. Int. J. Multiphase flow 36:202-209, 2010]. The channel geometries and flow conditions are re-constructed from recent experiments by Fallon [The Development of a Novel in vitro Flow System to Evaluate Platelet Activation and Procoagulant Potential Induced by Bileaflet Mechanical Heart Valve Leakage Jets in School of Chemical and Biomolecular Engineering. Atlanta: Georgia Institute of Technology] and Fallon et al. [Ann. Biomed. Eng. 36(1):1]. The fluid flow is computed on a fixed regular 'lattice' using the LBM, and each platelet is mapped onto a Lagrangian frame moving continuously throughout the fluid domain. The two-way fluid-solid interactions are determined by the EBF method by enforcing a no-slip condition on the platelet surface. The motion and orientation of the platelet are obtained from Newtonian dynamics equations. The numerical results show that sharp corners or sudden shape transitions will increase blood damage. Fallon's experimental results were used as a basis for choosing the appropriate BDI model for use in future computational simulations of flow through BMHVs.

  18. Electrical Engineering | Classification | College of Engineering & Applied

    Science.gov Websites

    ) 229-6916bsra@uwm.eduEng & Math Sciences 995 profile photo Robert Cuzner, Ph.D.Assistant ChairDepartment Chair of Electrical Engineering(414) 229-3885george@uwm.eduEng & Math Sciences 1245 profile photo Hossein Hosseini, Ph.D.ProfessorComputer Science(414) 229-5184hosseini@uwm.eduEng & Math

  19. Biomedical Engineering | Classification | College of Engineering & Applied

    Science.gov Websites

    Engineering, Biomedical Engineering(414) 229-6614wjchang@uwm.eduEng & Math Sciences 1113 profile photo Malkoc, Ph.D.Visiting Assistant ProfessorBiomedical Engineering414-229-6919malkoc@uwm.eduEng & Math Engineering / Electrical Engineering(414) 229-3327misra@uwm.eduEng & Math Sciences E-314 profile photo

  20. Computer Science | Classification | College of Engineering & Applied

    Science.gov Websites

    EMS 1011 profile photo Adrian Dumitrescu, Ph.D.ProfessorComputer Science(414) 229-4265Eng & Math @uwm.eduEng & Math Sciences 919 profile photo Hossein Hosseini, Ph.D.ProfessorComputer Science(414) 229 -5184hosseini@uwm.eduEng & Math Sciences 1091 profile photo Amol Mali, Ph.D.Associate ProfessorComputer

  1. Physiology driven adaptivity for the numerical solution of the bidomain equations.

    PubMed

    Whiteley, Jonathan P

    2007-09-01

    Previous work [Whiteley, J. P. IEEE Trans. Biomed. Eng. 53:2139-2147, 2006] derived a stable, semi-implicit numerical scheme for solving the bidomain equations. This scheme allows the timestep used when solving the bidomain equations numerically to be chosen by accuracy considerations rather than stability considerations. In this study we modify this scheme to allow an adaptive numerical solution in both time and space. The spatial mesh size is determined by the gradient of the transmembrane and extracellular potentials while the timestep is determined by the values of: (i) the fast sodium current; and (ii) the calcium release from junctional sarcoplasmic reticulum to myoplasm current. For two-dimensional simulations presented here, combining the numerical algorithm in the paper cited above with the adaptive algorithm presented here leads to an increase in computational efficiency by a factor of around 250 over previous work, together with significantly less computational memory being required. The speedup for three-dimensional simulations is likely to be more impressive.

  2. Mechanical Engineering | Classification | College of Engineering & Applied

    Science.gov Websites

    ProfessorMechanical Engineering(414) 229-6949avdeev@uwm.eduEng & Math Sciences 975 profile photo Robert Balmer, Sc . D.Professor EmeritusMechanical Engineering(414) 229-3374balmer@uwm.eduEng & Math Sciences E260 profile -6614wjchang@uwm.eduEng & Math Sciences 1113 profile photo Junhong Chen Ph.D.UWM Distinguished

  3. Materials Science & Engineering | Classification | College of Engineering &

    Science.gov Websites

    ChairMaterials Science and Engineering(414) 229-2668nidal@uwm.eduEng & Math Sciences E351 profile photo (414) 229-2615jhchen@uwm.eduEng & Math Sciences 1225 profile photo Benjamin Church, Ph.D.Associate ProfessorMaterials Science & Engineering(414) 229-2825church@uwm.eduEng & Math Sciences EMS 1175 profile

  4. Endoglin regulates renal ischaemia-reperfusion injury.

    PubMed

    Docherty, Neil G; López-Novoa, José M; Arevalo, Miguel; Düwel, Annette; Rodriguez-Peña, Ana; Pérez-Barriocanal, Fernando; Bernabeu, Carmelo; Eleno, Nélida

    2006-08-01

    Renal ischaemia-reperfusion (I-R) can cause acute tubular necrosis and chronic renal deterioration. Endoglin, an accessory receptor for Transforming Growth Factor-beta1 (TGF-beta1), is expressed on activated endothelium during macrophage maturation and implicated in the control of fibrosis, angiogenesis and inflammation. Endoglin expression was monitored over 14 days after renal I-R in rats. As endoglin-null mice are not viable, the role of endoglin in I-R was studied by comparing renal I-R injury in haploinsufficient mice (Eng(+/-)) and their wild-type littermates (Eng(+/+)). Renal function, morphology and molecular markers of acute renal injury and inflammation were compared. Endoglin mRNA up-regulation in the post-ischaemic kidneys of rats occurred at 12 h after I-R; endoglin protein levels were elevated throughout the study period. Expression was initially localized to the vascular endothelium, then extended to fibrotic and inflamed areas of the interstitium. Two days after I-R, plasma creatinine elevation and acute tubular necrosis were less marked in Eng(+/-) than in Eng(+/+) mice. Significant up-regulation of endoglin protein was found only in the post-ischaemic kidneys of Eng(+/+) mice and coincided with an increased mRNA expression of the TGF-beta1 and collagen IV (alpha1) chain genes. Significant increases in vascular cell adhesion molecule-1 (VCAM-1) and inducible nitric oxide synthase (iNOS) expression, nitrosative stress, myeloperoxidase activity and CD68 staining for macrophages were evident in post-ischaemic kidneys of Eng(+/+), but not Eng(+/-) mice, suggesting that impaired endothelial activation and macrophage maturation may account for the reduced injury in post-ischaemic kidneys of Eng(+/-) mice. Endoglin is up-regulated in the post-ischaemic kidney and endoglin-haploinsufficient mice are protected from renal I-R injury. Endoglin may play a primary role in promoting inflammatory responses following renal I-R.

  5. DD 21A-A Capable, Affordable, Modular 21st Century Destroyer

    DTIC Science & Technology

    1993-12-01

    1 1.000 2 0.OOOOE+00 3 0.OOOOE+00 4 1.000 5 1.000 ARRANGEMENT OPERATION SEP SS GEN OP ARRAY = ( 2X 1) 1 2.000 2 2.000 ARRANGEMENT CG MACHY KG IND... GEN SIZE IND = GIVEN SEP SS GEN KW = 2000.00 KW SS ENGINES SS ENG SELECT IND = GIVEN SS ENG MODEL IND = DDA-501-K17 SS ENG TYPE IND = GT SS ENG SIZE...1733.6 PROPELLERS: 2 - CP - 17.0 FT DIA AREA SUMMARY - FT2 SEP GEN : 3 CT 0 2000.0 KW HULL AREA - 55529.2 SUPERSTRUCTURE AREA - 21232.1 24 HR LOAD 1858.1

  6. Electronystagmography outcome and neuropsychological findings in tinnitus patients.

    PubMed

    Jozefowicz-Korczynska, Magdalena; Ciechomska, Elzbieta Agata; Pajor, Anna Maria

    2005-01-01

    Because psychological aspects often are underscored in the generation of tinnitus, we assessed the neuropsychological status in our group of patients. We found an increased number of abnormal electronystagmography (ENG) recordings in tinnitus patients. The aim of this study was to compare the ENG outcome with the patients' neuropsychological status. We carried out the study on 69 subjects complaining of tinnitus and on 43 healthy persons. We performed clinical neurootological examinations and ENG tests on all patients. Neuropsychological evaluation was conducted by means of the Beck Depression Inventory (BDI), the Hospital Anxiety and Depression (HAD) test, the Mini Mental Status (MMS) test, and the Trail-Making Test (TMT). In 46 patients (66.6%), we found abnormal ENG outcomes (central, 42%; peripheral, 13.0%; mixed, 11.6%). Neuropsychological tests revealed abnormal scores: for the BDI, 43.5% of patients; for the HAD-A, 72.5%; for the HAD-D, 47.8%; for the MMS, 27.5%; and for the TMT, 55.1%. We did not find correlation between the ENG outcomes and neuropsychological test scores. We did not find correlation between the overall ENG outcomes and neuropsychological test scores, with one exception; we found the occurrence of abnormal neuropsychological test scores and the ENG outcome indicating central vestibular dysfunction. Our study showed that despite a high frequency of vestibular system dysfunction signs and a high incidence of abnormal neuropsychological test scores in tinnitus patients, only one correlation existed between these two results.

  7. Ukrainian network of Optical Stations for man-made space objects observation

    NASA Astrophysics Data System (ADS)

    Sybiryakova, Yevgeniya

    2016-07-01

    The Ukrainian Network of Optical Stations (UNOS) for man-made objects research was founded in 2012 as an association of professional astronomers. The main goals of network are: positional and photometric observations of man-made space objects, calculation of orbital elements, research of shape and period of rotation. The network consists of 8 stations: Kiev, Nikolaev, Odesa, Uzhgorod, Lviv, Yevpatoriya, Alchevsk. UNOS has 12 telescopes for observation of man-made space objects. The new original methods of positional observation were developed for optical observation of geosynchronous and low earth orbit satellites. The observational campaigns of LEO satellites held in the network every year. The numerical model of space object motion, developed in UNOS, is using for orbit calculation. The results of orbital elements calculation are represented on the UNOS web-site http://umos.mao.kiev.ua/eng/. The photometric observation of selected objects is also carried out in network.

  8. Translations on Environmental Quality, Number 135

    DTIC Science & Technology

    1977-04-15

    Commission for Environmental Protection; I . Albulet, deputy secretary of the Mehedinti RCP County Committee; Prof. V. Ianovici, chairman of the National...of.pesticide poisoning during handling or from accidental ingestion. "Problems and Trends in the Research and Manufacture of Selective and I \\lon...Artemiza Dragomir, Eng I . Vacarciuc, Eng M. Pascu, and Eng Ileana Savescu: experiments conducted by the authors suggest the formulation of projects

  9. Translations on Eastern Europe, Scientific Affairs, Number 546.

    DTIC Science & Technology

    1977-05-27

    Tsurvenkov Prof. Tsvyatko Petkov Eng. Kiril Dochev Eng. Georgi Dimitrov Eng. Dimitur Petrov 26 Central Council of the Scientific and Technical...first deputy chairman of the Council of Ministers; Kiril Zarev, deputy chairman of the Council of Ministers and the chairman of the State Committee...deputy chairman: Engineer Georgi Dimitrov , deputy director for technical affairs and chairman of the scientific and technical society at the Vazovski

  10. Silicon Carbide Capacitive High Temperature MEMS Strain Transducer

    DTIC Science & Technology

    2012-03-22

    SILICON CARBIDE CAPACITIVE HIGH TEMPURATURE MEMS STRAIN TRANSDUCER THESIS Richard P. Weisenberger, DR01, USAF AFIT/GE/ENG...declared a work of the U.S. Government and is not subject to copyright protection in the United States AFIT/GE/ENG/12-43 SILICON CARBIDE CAPACITIVE...STATEMENT A. APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED AFIT/GE/ENG/12-43 SILICON CARBIDE CAPACITIVE IDGH TEMPURATURE MEMS STRAIN TRANSDUCER

  11. Circulating Soluble Endoglin Levels in Pregnant Women in Cameroon and Malawi—Associations with Placental Malaria and Fetal Growth Restriction

    PubMed Central

    Leke, Rose G. F.; Leke, Robert J. I.; Gwanmesia, Philomina; Molyneux, Malcolm E.; Wallace, Diane Taylor; Rogerson, Stephen J.; Kain, Kevin C.

    2011-01-01

    Placental infections with Plasmodium falciparum are associated with fetal growth restriction resulting in low birth weight (LBW). The mechanisms that mediate these effects have yet to be completely described; however, they are likely to involve inflammatory processes and dysregulation of angiogenesis. Soluble endoglin (sEng), a soluble receptor of transforming growth factor (TGF)-β previously associated with preeclampsia in pregnant women and with severe malaria in children, regulates the immune system and influences angiogenesis. We hypothesized that sEng may play a role in development of LBW associated with placental malaria (PM). Plasma levels of sEng were measured in women (i) followed prospectively throughout pregnancy in Cameroon (n = 52), and (ii) in a case-control study at delivery in Malawi (n = 479). The relationships between sEng levels and gravidity, peripheral and placental parasitemia, gestational age, and adverse outcomes of PM including maternal anemia and LBW were determined. In the longitudinal cohort from Cameroon, 28 of 52 women (54%) experienced at least one malaria infection during pregnancy. In Malawi we enrolled two aparasitemic gravidity-matched controls for every case with PM. sEng levels varied over the course of gestation and were significantly higher in early and late gestation as compared to delivery (P<0.006 and P<0.0001, respectively). Circulating sEng levels were higher in primigravidae than multigravidae from both Cameroon and Malawi, irrespective of malarial infection status (p<0.046 and p<0.001, respectively). Peripheral parasitemia in Cameroonian women and PM in Malawian women were each associated with elevated sEng levels following correction for gestational age and gravidity (p = 0.006 and p = 0.033, respectively). Increased sEng was also associated with the delivery of LBW infants in primigravid Malawian women (p = 0.017); the association was with fetal growth restriction (p = 0.003) but not pre-term delivery (p = 0.286). Increased circulating maternal sEng levels are associated with P. falciparum infection in pregnancy and with fetal growth restriction in primigravidae with PM. PMID:21966395

  12. Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction.

    PubMed

    Silver, Karlee L; Conroy, Andrea L; Leke, Rose G F; Leke, Robert J I; Gwanmesia, Philomina; Molyneux, Malcolm E; Taylor, Diane Wallace; Wallace, Diane Taylor; Rogerson, Stephen J; Kain, Kevin C

    2011-01-01

    Placental infections with Plasmodium falciparum are associated with fetal growth restriction resulting in low birth weight (LBW). The mechanisms that mediate these effects have yet to be completely described; however, they are likely to involve inflammatory processes and dysregulation of angiogenesis. Soluble endoglin (sEng), a soluble receptor of transforming growth factor (TGF)-β previously associated with preeclampsia in pregnant women and with severe malaria in children, regulates the immune system and influences angiogenesis. We hypothesized that sEng may play a role in development of LBW associated with placental malaria (PM). Plasma levels of sEng were measured in women (i) followed prospectively throughout pregnancy in Cameroon (n = 52), and (ii) in a case-control study at delivery in Malawi (n = 479). The relationships between sEng levels and gravidity, peripheral and placental parasitemia, gestational age, and adverse outcomes of PM including maternal anemia and LBW were determined. In the longitudinal cohort from Cameroon, 28 of 52 women (54%) experienced at least one malaria infection during pregnancy. In Malawi we enrolled two aparasitemic gravidity-matched controls for every case with PM. sEng levels varied over the course of gestation and were significantly higher in early and late gestation as compared to delivery (P<0.006 and P<0.0001, respectively). Circulating sEng levels were higher in primigravidae than multigravidae from both Cameroon and Malawi, irrespective of malarial infection status (p<0.046 and p<0.001, respectively). Peripheral parasitemia in Cameroonian women and PM in Malawian women were each associated with elevated sEng levels following correction for gestational age and gravidity (p = 0.006 and p = 0.033, respectively). Increased sEng was also associated with the delivery of LBW infants in primigravid Malawian women (p = 0.017); the association was with fetal growth restriction (p = 0.003) but not pre-term delivery (p = 0.286). Increased circulating maternal sEng levels are associated with P. falciparum infection in pregnancy and with fetal growth restriction in primigravidae with PM.

  13. Simultaneous quantitation of multiple contraceptive hormones in human serum by LC-MS/MS.

    PubMed

    Blue, Steven W; Winchell, Andrea J; Kaucher, Amy V; Lieberman, Rachel A; Gilles, Christopher T; Pyra, Maria N; Heffron, Renee; Hou, Xuanlin; Coombs, Robert W; Nanda, Kavita; Davis, Nicole L; Kourtis, Athena P; Herbeck, Joshua T; Baeten, Jared M; Lingappa, Jairam R; Erikson, David W

    2018-04-01

    The objective was to develop a method to simultaneously quantify five commonly used hormonal contraceptives (HCs) and two endogenous sex steroids by liquid chromatography-tandem triple quadrupole mass spectrometry (LC-MS/MS) and apply this method to human serum samples. We developed a method to simultaneously analyze ethinyl estradiol (EE2), etonogestrel (ENG), levonorgestrel (LNG), medroxyprogesterone acetate (MPA) and norethisterone (NET), along with estradiol (E2) and progesterone (P4), in human serum for a Shimadzu Nexera-LCMS-8050 LC-MS/MS platform. We analyzed serum collected from women self-reporting use of oral contraceptives, contraceptive implants or injectable contraceptives (n=14) and normally cycling women using no HC (n=15) as well as pooled samples from women administered various HCs (ENG, n=6; LNG, n=14; MPA, n=7; NET, n=5). Limits of quantitation were 0.010ng/mL for E2, EE2 and P4; 0.020ng/mL for ENG, LNG and MPA; and 0.040ng/mL for NET. Precisions for all assays, as indicated by coefficient of variation, were less than or equal to 12.1%. Accuracies for all assays were in the range of 95%-108%. Endogenous hormone values obtained from analysis of human serum samples are in agreement with levels previously reported in the literature for normally cycling women as well as for women taking the appropriate HC. We have developed a robust, accurate and sensitive method for simultaneously analyzing commonly used contraceptive steroids and endogenous sex steroids in human serum. This analytical method can be used for quantitating contraceptive steroid levels in women for monitoring systemic exposure to determine drug interactions, nonadherence, misreporting and proper dosing. Copyright © 2018 Elsevier Inc. All rights reserved.

  14. Surface polaritons in grating composed of left-handed materials

    NASA Astrophysics Data System (ADS)

    Tiwari, D. C.; Premlal, P. L.; Chaturvedi, Vandana

    2018-01-01

    In this work, we developed a unique mathematical model to solve dispersion relation for surface polaritons (SPs) in artificial composite materials grating. Here, we have taken two types of materials for analysis. In the first case, the grating composed of epsilon-negative (ENG) material and air interface. In second case, grating composed of left-handed materials (LHMs) and ENG medium interface is considered. The dispersion curves of both p and s polarized SPs modes are obtained analytically. In the case of ENG grating and air interface, polaritons dispersion curves exist for p-polarization only, whereas for LHM grating and ENG medium interface, the polaritons dispersion curves for both p and s polarization are observed.

  15. Immediate postpartum initiation of etonogestrel-releasing implant: A randomized controlled trial on breastfeeding impact.

    PubMed

    Braga, Giordana Campos; Ferriolli, Eduardo; Quintana, Silvana Maria; Ferriani, Rui Alberto; Pfrimer, Karina; Vieira, Carolina Sales

    2015-12-01

    Breast milk volume has never been evaluated when the etonogestrel (ENG) implant was inserted immediately postpartum. Thus, this study evaluated if the immediate postpartum insertion of the ENG implant alters breast milk volume. Twenty-four postpartum women and their newborns (NBs) were randomized into two groups: Implant group (ENG implant inserted within 48 h after delivery) and Control group (absence of contraceptive method). The primary outcome was the amount of breast milk intake by the NBs in the first 6 weeks after delivery. Five and ten grams of deuterium (D(2)O) were orally administered to the postpartum women on the day of randomization (day 0) and on the 29th study day, respectively. Saliva samples were collected from the mother-NB pairs prior to each D(2)O dose administration and after D(2)O ingestion (periodic collection). The amount of breast milk ingested by the NBs was estimated by the amount of deuterium (D(2)O) ingested by the NBs through breastfeeding, using mass spectrometry in the saliva samples. Twenty-four postpartum women and their NB were randomized (12 per group). The median of breast milk intake by NBs following the two D(2)O doses were similar between groups {first D(2)O dose [Implant: 340 mL/day (240-420 mL/day) vs. 330 mL/day (300-530 mL/day), p=.54]; second D(2)O dose [Implant: 845 mL/day (770-980 mL/day) vs. 785 mL/day (680-980 mL/day), p=.63]}. The exclusive breastfeeding rate and NB weight were similar between groups in the first 6 weeks postpartum. ENG implant insertion immediately postpartum does not alter the volume of breast milk intake by NBs. Considering the benefits of immediate postpartum initiation of ENG implant on reducing unintended pregnancy and pregnancy recurrence, especially in vulnerable populations, our study adds safety data on breastfeeding effect of this practice. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Behavioral Profiling of Scada Network Traffic Using Machine Learning Algorithms

    DTIC Science & Technology

    2014-03-27

    BEHAVIORAL PROFILING OF SCADA NETWORK TRAFFIC USING MACHINE LEARNING ALGORITHMS THESIS Jessica R. Werling, Captain, USAF AFIT-ENG-14-M-81 DEPARTMENT...subject to copyright protection in the United States. AFIT-ENG-14-M-81 BEHAVIORAL PROFILING OF SCADA NETWORK TRAFFIC USING MACHINE LEARNING ...AFIT-ENG-14-M-81 BEHAVIORAL PROFILING OF SCADA NETWORK TRAFFIC USING MACHINE LEARNING ALGORITHMS Jessica R. Werling, B.S.C.S. Captain, USAF Approved

  17. Security Verification of Secure MANET Routing Protocols

    DTIC Science & Technology

    2012-03-22

    SECURITY VERIFICATION OF SECURE MANET ROUTING PROTOCOLS THESIS Matthew F. Steele, Captain, USAF AFIT/GCS/ ENG /12-03 DEPARTMENT OF THE AIR FORCE AIR...States AFIT/GCS/ ENG /12-03 SECURITY VERIFICATION OF SECURE MANET ROUTING PROTOCOLS THESIS Presented to the Faculty Department of Electrical and Computer...DISTRIBUTION UNLIMITED AFIT/GCS/ ENG /12-03 SECURITY VERIFICATION OF SECURE MANET ROUTING PROTOCOLS Matthew F. Steele, B.S.E.E. Captain, USAF

  18. Recurrent Vestibular Migraine Vertigo Attacks Associated With the Development of Profound Bilateral Vestibulopathy: A Case Series.

    PubMed

    Wester, Jacob L; Ishiyama, Akira; Ishiyama, Gail

    2017-09-01

    Bilateral vestibulopathy (BVP) is a debilitating condition characterized by gait ataxia, oscillopsia, and imbalance. Case series of patients with migraine-linked vertigo spells and profound BVP. PATIENT 1:: A 69-year-old man presented with a history of recurrent severe vertigo spells lasting up to 3 days in duration associated with prostrating migraine headaches starting at age 60. His symptoms were misdiagnosed as an anxiety syndrome. At age 68, electronystagmography (ENG) revealed bilaterally absent caloric responses and complete BVP. His hearing was normal. PATIENT 2:: A 51-year-old man presented with a history of "earthquake-like" vertigo, sharp head pain, and phonophobia. These episodes occurred a handful of times over a 7-year period. Previous ENG testing at age 43 was normal. However, his ENG at age 48 revealed complete BVP. He was started on acetazolamide and noted improved balance, although subsequent ENG was unchanged. PATIENT 3:: A 49-year-old woman presented with a history of recurrent migraines with visual aura associated with vertigo lasting 1 hour. ENG at age 50 revealed complete BVP. Subjectively, she noted improved balance with acetazolamide and subsequent ENG demonstrated mild improvement. PATIENT 4:: A 43-year-old man presented with a 5-year history of optical migraines and recurrent vertigo spells, lasting 30 seconds, which was misdiagnosed as positional vertigo. He additionally had a 10-year history of oscillopsia. ENG at age 61 revealed complete BVP. In these cases, vestibular migraine was linked to recurrent vertigo spells that eventually led to complete bilateral vestibulopathy.

  19. A 12-month multicenter, randomized study comparing the levonorgestrel intrauterine system with the etonogestrel subdermal implant.

    PubMed

    Apter, Dan; Briggs, Paula; Tuppurainen, Marjo; Grunert, Julia; Lukkari-Lax, Eeva; Rybowski, Sarah; Gemzell-Danielsson, Kristina

    2016-07-01

    To compare the levonorgestrel intrauterine system (LNG-IUS 8), which has an average levonorgestrel release rate of ∼8 μg/24 hours during the first year (total levonorgestrel content 13.5 mg; Jaydess/Skyla), with the etonogestrel (ENG) subdermal implant (total content, 68 mg) with regard to the 12-month discontinuation rate (primary outcome). Randomized, open-label, phase III study. Thirty-eight centers in six European countries. Study population of 766 healthy nulliparous and parous women aged 18-35 years. The LNG-IUS 8 or the ENG implant. Discontinuation rate, by treatment group, at Month 12. The 12-month discontinuation rates were 19.6% and 26.8% in the LNG-IUS 8 and ENG implant groups, respectively. The -7.2% difference was statistically significant (95% confidence interval -13.2%, -1.2%). Fewer women in the LNG-IUS 8 group than in the ENG implant group discontinued because of increased bleeding (3.2% vs. 11.3%) or adverse events (14.3% vs. 21.8%). At 12 months, more women in the LNG-IUS 8 group than in the ENG implant group were "very/somewhat satisfied" with their bleeding pattern (60.9% vs. 33.6%) and reported a preference to use their study treatment after study completion (70.1% vs. 58.5%). The LNG-IUS 8 was associated with a significantly lower 12-month discontinuation rate compared with the ENG implant; mainly because ENG implant users frequently discontinued due to increased bleeding. More LNG-IUS 8 users than ENG implant users reported being "very/somewhat satisfied" with their bleeding pattern, and reported a preference to continue using their study treatment after the study. NCT01397097. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  20. Solubility Prediction of Active Pharmaceutical Compounds with the UNIFAC Model

    NASA Astrophysics Data System (ADS)

    Nouar, Abderrahim; Benmessaoud, Ibtissem; Koutchoukali, Ouahiba; Koutchoukali, Mohamed Salah

    2016-03-01

    The crystallization from solution of an active pharmaceutical ingredient requires the knowledge of the solubility in the entire temperature range investigated during the process. However, during the development of a new active ingredient, these data are missing. Its experimental determination is possible, but tedious. UNIFAC Group contribution method Fredenslund et al. (Vapor-liquid equilibria using UNIFAC: a group contribution method, 1977; AIChE J 21:1086, 1975) can be used to predict this physical property. Several modifications on this model have been proposed since its development in 1977, modified UNIFAC of Dortmund Weidlich et al. (Ind Eng Chem Res 26:1372, 1987), Gmehling et al. (Ind Eng Chem Res 32:178, 1993), Pharma-modified UNIFAC Diedrichs et al. (Evaluation und Erweiterung thermodynamischer Modelle zur Vorhersage von Wirkstofflöslichkeiten, PhD Thesis, 2010), KT-UNIFAC Kang et al. (Ind Eng Chem Res 41:3260, 2002), ldots In this study, we used UNIFAC model by considering the linear temperature dependence of interaction parameters as in Pharma-modified UNIFAC and structural groups as defined by KT-UNIFAC first-order model. More than 100 binary datasets were involved in the estimation of interaction parameters. These new parameters were then used to calculate activity coefficient and solubility of some molecules in various solvents at different temperatures. The model gives better results than those from the original UNIFAC and shows good agreement between the experimental solubility and the calculated one.

  1. Efficient and accurate two-scale FE-FFT-based prediction of the effective material behavior of elasto-viscoplastic polycrystals

    NASA Astrophysics Data System (ADS)

    Kochmann, Julian; Wulfinghoff, Stephan; Ehle, Lisa; Mayer, Joachim; Svendsen, Bob; Reese, Stefanie

    2018-06-01

    Recently, two-scale FE-FFT-based methods (e.g., Spahn et al. in Comput Methods Appl Mech Eng 268:871-883, 2014; Kochmann et al. in Comput Methods Appl Mech Eng 305:89-110, 2016) have been proposed to predict the microscopic and overall mechanical behavior of heterogeneous materials. The purpose of this work is the extension to elasto-viscoplastic polycrystals, efficient and robust Fourier solvers and the prediction of micromechanical fields during macroscopic deformation processes. Assuming scale separation, the macroscopic problem is solved using the finite element method. The solution of the microscopic problem, which is embedded as a periodic unit cell (UC) in each macroscopic integration point, is found by employing fast Fourier transforms, fixed-point and Newton-Krylov methods. The overall material behavior is defined by the mean UC response. In order to ensure spatially converged micromechanical fields as well as feasible overall CPU times, an efficient but simple solution strategy for two-scale simulations is proposed. As an example, the constitutive behavior of 42CrMo4 steel is predicted during macroscopic three-point bending tests.

  2. Efficient and accurate two-scale FE-FFT-based prediction of the effective material behavior of elasto-viscoplastic polycrystals

    NASA Astrophysics Data System (ADS)

    Kochmann, Julian; Wulfinghoff, Stephan; Ehle, Lisa; Mayer, Joachim; Svendsen, Bob; Reese, Stefanie

    2017-09-01

    Recently, two-scale FE-FFT-based methods (e.g., Spahn et al. in Comput Methods Appl Mech Eng 268:871-883, 2014; Kochmann et al. in Comput Methods Appl Mech Eng 305:89-110, 2016) have been proposed to predict the microscopic and overall mechanical behavior of heterogeneous materials. The purpose of this work is the extension to elasto-viscoplastic polycrystals, efficient and robust Fourier solvers and the prediction of micromechanical fields during macroscopic deformation processes. Assuming scale separation, the macroscopic problem is solved using the finite element method. The solution of the microscopic problem, which is embedded as a periodic unit cell (UC) in each macroscopic integration point, is found by employing fast Fourier transforms, fixed-point and Newton-Krylov methods. The overall material behavior is defined by the mean UC response. In order to ensure spatially converged micromechanical fields as well as feasible overall CPU times, an efficient but simple solution strategy for two-scale simulations is proposed. As an example, the constitutive behavior of 42CrMo4 steel is predicted during macroscopic three-point bending tests.

  3. Bibliography on Cold Regions Science and Technology. Volume 51, Part 2.

    DTIC Science & Technology

    1997-12-01

    sediments, Tuktoyaktuk Coast- lands, western arctic Canada [1996, eng] 51-241 Musaeva ,E.I. Comparison of various Zooplankton sampling tools...catches in the Bering Sea. Musaeva , E.I., et al, [1996,eng] 51-638 Copepod vertical distribution in ice-covered Resolute Passage, Canada. Hattori, H., ct...various Zooplankton sampling tools based on catches in the Bering Sea. Musaeva , E.I., et al, [1996,eng] 51-638 Conference portfolio. International

  4. Lynn Westdal | NREL

    Science.gov Websites

    Process-relevant Biomass-derived Pentoses in a Biphasic Reaction System," ACS Sustainable Chem. Eng Biomass-derived Pentoses in a Biphasic Reaction System." ACS Sustainable Chem. Eng. (2017)

  5. Transforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation.

    PubMed

    Tal, Reshef; Seifer, David B; Shohat-Tal, Aya; Grazi, Richard V; Malter, Henry E

    2013-08-01

    To evaluate the relationship between transforming growth factor (TGF)-β1 and its receptor, soluble endoglin (sENG), in the serum and follicular fluid of women with polycystic ovarian syndrome (PCOS) compared with that of non-PCOS normal ovulating women during controlled ovarian stimulation (COS). Prospective case-control study. Academic-affiliated assisted reproductive technology unit. Fourteen PCOS and 14 matched non-PCOS control women undergoing COS. Serum was collected on day 3 (baseline), day of hCG, and day of retrieval. Follicular fluid (FF) was collected on day of oocyte retrieval. ELISA was performed to determine TGF-β1 and sENG protein levels. Serum and FF levels of TGF-β1 and sENG. Serum TGF-β1 did not change significantly during COS but was increased in PCOS compared with non-PCOS women on day 3 and days of hCG administration and oocyte retrieval. Serum sENG increased after hCG administration only in the non-PCOS control group. In addition, serum sENG was decreased in PCOS compared with non-PCOS control women on the days of hCG and retrieval. Accordingly, the bioavailability of TGF-β1 (TGF-β1/sENG ratio) was increased in women with PCOS compared with non-PCOS controls at all three time points. No differences in either factor were noted in FF between groups. The increased TGF-β1 bioavailability in PCOS is not only due to increased TGF-β1 levels but also to decreased levels of its receptor, sENG. These data suggest that increased TGF-β1 bioavailability may contribute to the pathogenesis of PCOS and its increased risk for ovarian hyperstimulation. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  6. Goal-oriented explicit residual-type error estimates in XFEM

    NASA Astrophysics Data System (ADS)

    Rüter, Marcus; Gerasimov, Tymofiy; Stein, Erwin

    2013-08-01

    A goal-oriented a posteriori error estimator is derived to control the error obtained while approximately evaluating a quantity of engineering interest, represented in terms of a given linear or nonlinear functional, using extended finite elements of Q1 type. The same approximation method is used to solve the dual problem as required for the a posteriori error analysis. It is shown that for both problems to be solved numerically the same singular enrichment functions can be used. The goal-oriented error estimator presented can be classified as explicit residual type, i.e. the residuals of the approximations are used directly to compute upper bounds on the error of the quantity of interest. This approach therefore extends the explicit residual-type error estimator for classical energy norm error control as recently presented in Gerasimov et al. (Int J Numer Meth Eng 90:1118-1155, 2012a). Without loss of generality, the a posteriori error estimator is applied to the model problem of linear elastic fracture mechanics. Thus, emphasis is placed on the fracture criterion, here the J-integral, as the chosen quantity of interest. Finally, various illustrative numerical examples are presented where, on the one hand, the error estimator is compared to its finite element counterpart and, on the other hand, improved enrichment functions, as introduced in Gerasimov et al. (2012b), are discussed.

  7. Wavelet Packet Analysis for Angular Data Extraction from Muscle Afferent Cuff Electrode Signals

    DTIC Science & Technology

    2001-10-25

    from rabbits. In order to estimate ankle flexion/extension angles, we recorded ENG signals from the left Tibial and Peroneal nerves, both during FES...afferent ENG. II. METHODOLOGY A. Experimental Setup Acute experiments were conducted with 2 female New Zealand rabbits. The rabbits were pre-anesthetized...fixating the knee and ankle joints in place (see [3] for more details) . For extracting the ENG signals, tripolar cuff electrodes were implanted onto the

  8. Tactical AI in Real Time Strategy Games

    DTIC Science & Technology

    2015-03-26

    TACTICAL AI IN REAL TIME STRATEGY GAMES THESIS Donald A. Gruber, Capt, USAF AFIT-ENG-MS-15-M-021 DEPARTMENT OF THE AIR FORCE AIR UNIVERSITY AIR FORCE...protection in the United States. AFIT-ENG-MS-15-M-021 TACTICAL AI IN REAL TIME STRATEGY GAMES THESIS Presented to the Faculty Department of Electrical...DISTRIBUTION STATEMENT A APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. AFIT-ENG-MS-15-M-021 TACTICAL AI IN REAL TIME STRATEGY GAMES THESIS Donald A

  9. Student Modeling in an Intelligent Tutoring System

    DTIC Science & Technology

    1996-12-17

    Multi-Agent Architecture." Advances in Artificial Intelligence : Proceedings of the 12 th Brazilian Symposium on Aritificial Intelligence , edited by...STUDENT MODELING IN AN INTELLIGENT TUTORING SYSTEM THESIS Jeremy E. Thompson Captain, USAF AFIT/GCS/ENG/96D-27 DIMTVMON* fCKAJWINT A Appr"v*d t=i...Air Force Base, Ohio AFIT/GCS/ENG/96D-27 STUDENT MODELING IN AN INTELLIGENT TUTORING SYSTEM THESIS Jeremy E. Thompson Captain, USAF AFIT/GCS/ENG/96D

  10. A 3-year multicentre randomized controlled trial of etonogestrel- and levonorgestrel-releasing contraceptive implants, with non-randomized matched copper-intrauterine device controls.

    PubMed

    Bahamondes, Luis; Brache, Vivian; Meirik, Olav; Ali, Moazzam; Habib, Ndema; Landoulsi, Sihem

    2015-11-01

    Is there any difference in the clinical performance of the 3-year one-rod etonogestrel (ENG)- and the 5-year two-rod levonorgestrel (LNG)-releasing contraceptive implants during 3 years of insertion, and between implant and intrauterine device (IUD) contraception, in particular complaints possibly related to hormonal contraceptives? The cumulative contraceptive effectiveness after 3 years and method continuation through 2.5 years were not significantly different between ENG and LNG implants, but both outcomes were significantly worse in the non-randomized age-matched group of IUD users than in the combined implant group. ENG- and LNG-releasing implants are safe and highly efficacious contraceptives with pregnancy rates reported to be 0.0-0.5 per 100 women-years (W-Y). No head-to-head comparative study of the two implants has been undertaken, and little information is available on comparisons of complaints of side effects of implant and copper IUD users. This was an open parallel group RCT with 1:1 allocation ratio of the ENG and the LNG implants with non-randomized control group of women choosing TCu380A IUD to address lack of reliable data on common side effects typically attributed to the use of progestogen-only contraceptives. After device(s) placement, follow-ups were at 2 weeks, 3 and 6 months, and semi-annually thereafter for 3 years or until pregnancy, removal or expulsion of the implant/IUD occurred. The study took place in family planning clinics in Brazil, Chile, Dominican Republic, Hungary, Thailand, Turkey and Zimbabwe. Women seeking long-term contraception were enlisted after an eligibility check and informed consent, and 2982 women were enrolled: 1003, 1005 and 974 in the ENG-implant, LNG-implant and IUD groups, respectively; 995, 997 and 971, respectively, were included in the per protocol analysis reported here. ENG and LNG implants each had the same 3-year cumulative pregnancy rate of 0.4 per 100 W-Y [95% confidence interval (CI) 0.1-1.4]. A weight of ≥70 kg at admission was unrelated to pregnancy. Method continuation rates for ENG and LNG implants at 2.5 years were 69.8 (95% CI 66.8-72.6) and 71.8 per 100 W-Y (68.8-74.5), and at 3 years 12.1 (95% CI 5.2-22.0) and 52.0 per 100 W-Y (95% CI 41.8-61.2), respectively. Bleeding disturbances, the most frequent reason for method discontinuation, were significantly more common in the ENG group [16.7 (95% CI 14.4-19.3)] than in the LNG group [12.5 (95% CI 10.5-14.9)] (P 0.019). The 3-year cumulative loss to follow-up was lower in the ENG- than in the LNG-implant group, 8.1 (95% CI 6.4-10.2) and 14.4 per 100 W-Y (95% CI 12.1-17.1), respectively. The median duration of implant removal was 50 s shorter among women with ENG than among women with LNG implant (P < 0.0001). In the observational comparison between IUD and implant users, the 3-year relative risk for pregnancy in IUD group compared with the combined implant group was 5.7 per 100 W-Y (95% CI 4.4-7.3) (P = 0.0003). The 3-year expulsion rate of the IUD was 17.8 per 100 W-Y (95% CI 14.5-21.9), while the discontinuation rate for bleeding disturbances was 8.5 (95% CI 6.7-10.9). Frequency of complaints of headache and dizziness was not significantly different between implant and IUD users (P = 0.16 and 0.77, respectively), acne and bleeding irregularities were more frequent among implant users (P < 0.0001), while heavy bleeding and lower abdominal pain occurred more often among IUD than implant users (P < 0.0001). Few women were ≤19 years old or nulligravida, the proportion of implant users ≥70 kg was <20% and <8% were obese. Findings of the study can inform policy makers and clinicians about choice of implant, but also about TCu380A IUD in relation to implants. UNDP/UNFPA/WHO/UNICEF/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research (RHR), World Health Organization (WHO). This report contains the views of an international expert group and does not necessarily represent the decisions or the stated policy of the WHO. ISRCTN33378571 registered on 22 March 2004. The first participant was enrolled on 12 May 2003. © The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  11. The effect of mental alerting on peripheral vestibular nystagmus during spontaneous, gaze (30 degrees left, 30 degrees right) and body positional (left & right lateral lying) testing using electronystagmography (ENG).

    PubMed

    McGovern, Tracey N; Fitzgerald, John E

    2008-10-01

    The performance of mental alerting during caloric testing has always been considered important, however its use/benefit during electronystagmography (ENG)/videonystagmography (VNG) testing has been questioned. The aim of this study was to investigate the effect of mental alerting tasks on peripheral type vestibular nystagmus recorded during ENG. Thirty patients with significant spontaneous/gaze or positional nystagmus (slow phase velocity >or= 6 degrees /s) were recruited from consecutive referrals for vestibular assessment. Nystagmus was recorded by ENG both in the presence and absence of mental alerting for each patient. Investigation of nystagmus by analysis of variance (ANOVA) revealed significantly larger nystagmus (higher value SPV) with mental alerting than with no alerting (p<0.001), and for some patients nystagmus traces were reduced to a flat line (no nystagmus) with no alerting. The study demonstrates the importance of mental alerting in helping overcome central suppression of nystagmus and highlights its importance to help identify peripheral type nystagmus during ENG.

  12. A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia.

    PubMed

    Ermini, Leonardo; Ausman, Jonathan; Melland-Smith, Megan; Yeganeh, Behzad; Rolfo, Alessandro; Litvack, Michael L; Todros, Tullia; Letarte, Michelle; Post, Martin; Caniggia, Isabella

    2017-09-22

    Preeclampsia (PE), an hypertensive disorder of pregnancy, exhibits increased circulating levels of a short form of the auxillary TGF-beta (TGFB) receptor endoglin (sENG). Until now, its release and functionality in PE remains poorly understood. Here we show that ENG selectively interacts with sphingomyelin(SM)-18:0 which promotes its clustering with metalloproteinase 14 (MMP14) in SM-18:0 enriched lipid rafts of the apical syncytial membranes from PE placenta where ENG is cleaved by MMP14 into sENG. The SM-18:0 enriched lipid rafts also contain type 1 and 2 TGFB receptors (TGFBR1 and TGFBR2), but not soluble fms-like tyrosine kinase 1 (sFLT1), another protein secreted in excess in the circulation of women with PE. The truncated ENG is then released into the maternal circulation via SM-18:0 enriched exosomes together with TGFBR1 and 2. Such an exosomal TGFB receptor complex could be functionally active and block the vascular effects of TGFB in the circulation of PE women.

  13. Maxwell-Stefan diffusion coefficient estimation for ternary systems: an ideal ternary alcohol system.

    PubMed

    Allie-Ebrahim, Tariq; Zhu, Qingyu; Bräuer, Pierre; Moggridge, Geoff D; D'Agostino, Carmine

    2017-06-21

    The Maxwell-Stefan model is a popular diffusion model originally developed to model diffusion of gases, which can be considered thermodynamically ideal mixtures, although its application has been extended to model diffusion in non-ideal liquid mixtures as well. A drawback of the model is that it requires the Maxwell-Stefan diffusion coefficients, which are not based on measurable quantities but they have to be estimated. As a result, numerous estimation methods, such as the Darken model, have been proposed to estimate these diffusion coefficients. However, the Darken model was derived, and is only well defined, for binary systems. This model has been extended to ternary systems according to two proposed forms, one by R. Krishna and J. M. van Baten, Ind. Eng. Chem. Res., 2005, 44, 6939-6947 and the other by X. Liu, T. J. H. Vlugt and A. Bardow, Ind. Eng. Chem. Res., 2011, 50, 10350-10358. In this paper, the two forms have been analysed against the ideal ternary system of methanol/butan-1-ol/propan-1-ol and using experimental values of self-diffusion coefficients. In particular, using pulsed gradient stimulated echo nuclear magnetic resonance (PGSTE-NMR) we have measured the self-diffusion coefficients in various methanol/butan-1-ol/propan-1-ol mixtures. The experimental values of self-diffusion coefficients were then used as the input data required for the Darken model. The predictions of the two proposed multicomponent forms of this model were then compared to experimental values of mutual diffusion coefficients for the ideal alcohol ternary system. This experimental-based approach showed that the Liu's model gives better predictions compared to that of Krishna and van Baten, although it was only accurate to within 26%. Nonetheless, the multicomponent Darken model in conjunction with self-diffusion measurements from PGSTE-NMR represents an attractive method for a rapid estimation of mutual diffusion in multicomponent systems, especially when compared to exhaustive MD simulations.

  14. Computational cardiology: the bidomain based modified Hill model incorporating viscous effects for cardiac defibrillation

    NASA Astrophysics Data System (ADS)

    Cansız, Barış; Dal, Hüsnü; Kaliske, Michael

    2017-10-01

    Working mechanisms of the cardiac defibrillation are still in debate due to the limited experimental facilities and one-third of patients even do not respond to cardiac resynchronization therapy. With an aim to develop a milestone towards reaching the unrevealed mechanisms of the defibrillation phenomenon, we propose a bidomain based finite element formulation of cardiac electromechanics by taking into account the viscous effects that are disregarded by many researchers. To do so, the material is deemed as an electro-visco-active material and described by the modified Hill model (Cansız et al. in Comput Methods Appl Mech Eng 315:434-466, 2017). On the numerical side, we utilize a staggered solution method, where the elliptic and parabolic part of the bidomain equations and the mechanical field are solved sequentially. The comparative simulations designate that the viscoelastic and elastic formulations lead to remarkably different outcomes upon an externally applied electric field to the myocardial tissue. Besides, the achieved framework requires significantly less computational time and memory compared to monolithic schemes without loss of stability for the presented examples.

  15. Bibliography on Cold Regions Science and Technology Volume 53, Part 2

    DTIC Science & Technology

    1999-12-01

    A.T. Claud, C. 53-1504 Interaction of ice floes with ships on offshore structures Case study of antarctic mesolow [1995, eng] 53-329 Coffey, M.T. [1992...in a dry-snow Dethloff, K Biogeochemistry of antarctic sea ice: a case study on avalanche [1998, eng] 53-2018 Climate variability in a nonlinear...concrete with respect to Effect of the Endicott Causeway on the population of Ferguson, M.E. frost resistance: a case study [1998, eng] 53-952 broad

  16. A Radiosity Approach to Realistic Image Synthesis

    DTIC Science & Technology

    1992-12-01

    AD-A259 082 AFIT/GCE/ENG/92D-09 A RADIOSITY APPROACH TO REALISTIC IMAGE SYNTHESIS THESIS Richard L. Remington Captain, USAF fl ECTE AFIT/GCE/ENG/92D...09 SJANl 1993U 93-00134 Approved for public release; distribution unlimited 93& 1! A -A- AFIT/GCE/ENG/92D-09 A RADIOSITY APPROACH TO REALISTIC IMAGE...assistance in creating the input geometry file for the AWACS aircraft interior. Without his assistance, a good model for the diffuse radiosity implementation

  17. Multimedia Archiving: Videotape, Compact Disc (CD), Digital Versatile Disc (DVD), and Blu-Ray Disc (BD) Media

    DTIC Science & Technology

    2010-02-01

    color and memory SMPTE Society of Motion Picture and Television Engineers SP Superior Performance ( Betacam SP) S-VHS Super VHS TBC time base...modified Iron Oxide 1.5 mil 3/4 inch ENG, Independent production Betamax 1/2 inch Consumer Betacam Cobalt-modified Iron Oxide, Chromium Dioxide 0.8...mil 1/2 inch ENG, Independent production, Government Betacam SP Metal particle 0.55 mil 1/2 inch ENG, Independent production M-II Metal particle

  18. High-Performance Parallel Analysis of Coupled Problems for Aircraft Propulsion

    NASA Technical Reports Server (NTRS)

    Felippa, C. A.; Farhat, C.; Park, K. C.; Gumaste, U.; Chen, P.-S.; Lesoinne, M.; Stern, P.

    1996-01-01

    This research program dealt with the application of high-performance computing methods to the numerical simulation of complete jet engines. The program was initiated in January 1993 by applying two-dimensional parallel aeroelastic codes to the interior gas flow problem of a bypass jet engine. The fluid mesh generation, domain decomposition and solution capabilities were successfully tested. Attention was then focused on methodology for the partitioned analysis of the interaction of the gas flow with a flexible structure and with the fluid mesh motion driven by these structural displacements. The latter is treated by a ALE technique that models the fluid mesh motion as that of a fictitious mechanical network laid along the edges of near-field fluid elements. New partitioned analysis procedures to treat this coupled three-component problem were developed during 1994 and 1995. These procedures involved delayed corrections and subcycling, and have been successfully tested on several massively parallel computers, including the iPSC-860, Paragon XP/S and the IBM SP2. For the global steady-state axisymmetric analysis of a complete engine we have decided to use the NASA-sponsored ENG10 program, which uses a regular FV-multiblock-grid discretization in conjunction with circumferential averaging to include effects of blade forces, loss, combustor heat addition, blockage, bleeds and convective mixing. A load-balancing preprocessor tor parallel versions of ENG10 was developed. During 1995 and 1996 we developed the capability tor the first full 3D aeroelastic simulation of a multirow engine stage. This capability was tested on the IBM SP2 parallel supercomputer at NASA Ames. Benchmark results were presented at the 1196 Computational Aeroscience meeting.

  19. Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14.

    PubMed

    Letteboer, Tom G W; Benzinou, Michael; Merrick, Christopher B; Quigley, David A; Zhau, Kechen; Kim, Il-Jin; To, Minh D; Jablons, David M; van Amstel, Johannes K P; Westermann, Cornelius J J; Giraud, Sophie; Dupuis-Girod, Sophie; Lesca, Gaetan; Berg, Jonathan H; Balmain, Allan; Akhurst, Rosemary J

    2015-01-01

    HHT shows clinical variability within and between families. Organ site and prevalence of arteriovenous malformations (AVMs) depend on the HHT causative gene and on environmental and genetic modifiers. We tested whether variation in the functional ENG allele, inherited from the unaffected parent, alters risk for pulmonary AVM in HHT1 mutation carriers who are ENG haploinsufficient. Genetic association was found between rs10987746 of the wild type ENG allele and presence of pulmonary AVM [relative risk = 1.3 (1.0018-1.7424)]. The rs10987746-C at-risk allele associated with lower expression of ENG RNA in a panel of human lymphoblastoid cell lines (P = 0.004). Moreover, in angiogenically active human lung adenocarcinoma tissue, but not in uninvolved quiescent lung, rs10987746-C was correlated with expression of PTPN14 (P = 0.004), another modifier of HHT. Quantitative TAQMAN expression analysis in a panel of normal lung tissues from 69 genetically heterogeneous inter-specific backcross mice, demonstrated strong correlation between expression levels of Eng, Acvrl1, and Ptpn14 (r2 = 0.75-0.9, P < 1 × 10(-12)), further suggesting a direct or indirect interaction between these three genes in lung in vivo. Our data indicate that genetic variation within the single functional ENG gene influences quantitative and/or qualitative differences in ENG expression that contribute to risk of pulmonary AVM in HHT1, and provide correlative support for PTPN14 involvement in endoglin/ALK1 lung biology in vivo. PTPN14 has been shown to be a negative regulator of Yap/Taz signaling, which is implicated in mechanotransduction, providing a possible molecular link between endoglin/ALK1 signaling and mechanical stress. EMILIN2, which showed suggestive genetic association with pulmonary AVM, is also reported to interact with Taz in angiogenesis. Elucidation of the molecular mechanisms regulating these interactions in endothelial cells may ultimately provide more rational choices for HHT therapy.

  20. [Historia magistra vitae: on the methods of historical demography].

    PubMed

    Botev, N

    1992-01-01

    Indirect estimation techniques are applied to data for Bulgaria from 1891 to 1958 to assess trends in population dynamics. An interdisciplinary approach is suggested for the study of countries where data are often incomplete. (SUMMARY IN ENG AND RUS)

  1. PEMFC for aeronautic applications: A review on the durability aspects

    NASA Astrophysics Data System (ADS)

    Dyantyi, Noluntu; Parsons, Adrian; Sita, Cordellia; Pasupathi, Sivakumar

    2017-11-01

    Proton exchange membrane fuel cells (PEMFC) not only offer more efficient electrical energy conversion, relative to on-ground/backup turbines but generate by-products useful in aircraft such as heat for ice prevention, deoxygenated air for fire retardation and drinkable water for use on-board. Consequently, several projects (e.g. DLR-H2 Antares and RAPID2000) have successfully tested PEMFC-powered auxiliary unit (APU) for manned/unmanned aircraft. Despite the progress from flying PEMFC-powered small aircraft with 20 kW power output as high as 1 000 m at 100 km/h to 33 kW at 2 558 m, 176 km/h [1, 2, 3], durability and reliability remain key challenges. This review reports on the inadequate understanding of behaviour of PEMFC under aeronautic conditions and the lack of predictive methods conducive for aircraft that provide real-time information on the State of Health of PEMFCs. To minimize performance loss due to high altitude and inclination by adjusting cathode stoichiometric ratio. To improve quality of oxygen-depleted air by controlling operating temperature and stoichiometric ratio. Need to devise real time prediction methods conducive for determining PEMFC SoH in aircraft.

  2. L-Endoglin Overexpression Increases Renal Fibrosis after Unilateral Ureteral Obstruction

    PubMed Central

    Arévalo, Miguel; Núñez-Gómez, Elena; Pérez-Roque, Lucía; Pericacho, Miguel; González-Núñez, María; Langa, Carmen; Martínez-Salgado, Carlos; Perez-Barriocanal, Fernando; Bernabeu, Carmelo; Lopez-Novoa, José M.

    2014-01-01

    Transforming growth factor-β (TGF-β) plays a pivotal role in renal fibrosis. Endoglin, a 180 KDa membrane glycoprotein, is a TGF-β co-receptor overexpressed in several models of chronic kidney disease, but its function in renal fibrosis remains uncertain. Two membrane isoforms generated by alternative splicing have been described, L-Endoglin (long) and S-Endoglin (short) that differ from each other in their cytoplasmic tails, being L-Endoglin the most abundant isoform. The aim of this study was to assess the effect of L-Endoglin overexpression in renal tubulo-interstitial fibrosis. For this purpose, a transgenic mouse which ubiquitously overexpresses human L-Endoglin (L-ENG+) was generated and unilateral ureteral obstruction (UUO) was performed in L-ENG+ mice and their wild type (WT) littermates. Obstructed kidneys from L-ENG+ mice showed higher amounts of type I collagen and fibronectin but similar levels of α-smooth muscle actin (α-SMA) than obstructed kidneys from WT mice. Smad1 and Smad3 phosphorylation were significantly higher in obstructed kidneys from L-ENG+ than in WT mice. Our results suggest that the higher increase of renal fibrosis observed in L-ENG+ mice is not due to a major abundance of myofibroblasts, as similar levels of α-SMA were observed in both L-ENG+ and WT mice, but to the higher collagen and fibronectin synthesis by these fibroblasts. Furthermore, in vivo L-Endoglin overexpression potentiates Smad1 and Smad3 pathways and this effect is associated with higher renal fibrosis development. PMID:25313562

  3. Numerical computation of gravitational field of general extended body and its application to rotation curve study of galaxies

    NASA Astrophysics Data System (ADS)

    Fukushima, Toshio

    2017-06-01

    Reviewed are recently developed methods of the numerical integration of the gravitational field of general two- or three-dimensional bodies with arbitrary shape and mass density distribution: (i) an axisymmetric infinitely-thin disc (Fukushima 2016a, MNRAS, 456, 3702), (ii) a general infinitely-thin plate (Fukushima 2016b, MNRAS, 459, 3825), (iii) a plane-symmetric and axisymmetric ring-like object (Fukushima 2016c, AJ, 152, 35), (iv) an axisymmetric thick disc (Fukushima 2016d, MNRAS, 462, 2138), and (v) a general three-dimensional body (Fukushima 2016e, MNRAS, 463, 1500). The key techniques employed are (a) the split quadrature method using the double exponential rule (Takahashi and Mori, 1973, Numer. Math., 21, 206), (b) the precise and fast computation of complete elliptic integrals (Fukushima 2015, J. Comp. Appl. Math., 282, 71), (c) Ridder's algorithm of numerical differentiaion (Ridder 1982, Adv. Eng. Softw., 4, 75), (d) the recursive computation of the zonal toroidal harmonics, and (e) the integration variable transformation to the local spherical polar coordinates. These devices succesfully regularize the Newton kernel in the integrands so as to provide accurate integral values. For example, the general 3D potential is regularly integrated as Φ (\\vec{x}) = - G \\int_0^∞ ( \\int_{-1}^1 ( \\int_0^{2π} ρ (\\vec{x}+\\vec{q}) dψ ) dγ ) q dq, where \\vec{q} = q (√{1-γ^2} cos ψ, √{1-γ^2} sin ψ, γ), is the relative position vector referred to \\vec{x}, the position vector at which the potential is evaluated. As a result, the new methods can compute the potential and acceleration vector very accurately. In fact, the axisymmetric integration reproduces the Miyamoto-Nagai potential with 14 correct digits. The developed methods are applied to the gravitational field study of galaxies and protoplanetary discs. Among them, the investigation on the rotation curve of M33 supports a disc-like structure of the dark matter with a double-power-law surface mass density distribution. Fortran 90 subroutines to execute these methods and their test programs and sample outputs are available from the author's WEB site: https://www.researchgate.net/profile/Toshio_Fukushima/

  4. Comparison of empirical and numerical methods for the assessment of coastal vulnerability to erosion

    NASA Astrophysics Data System (ADS)

    Kokkinos, Dimitris; Prinos, Panagiotis

    2017-04-01

    Assessing the vulnerability to erosion is an important step in order to identify the prone areas and propose an adaptation policy to climate change in coastal areas. In this paper two coastal areas at the Northern part of the Aegean Sea are selected to examine their vulnerability to erosion. The first case is Lesbos Island where the most common feature is pocket beaches and the second one is the coast of Thrace composed by long sandy beaches. In both case studies, the same simplified methodology proposed by Mendoza and Jimenez (2009) is used, which links the vulnerability to erosion with morphodynamic parameters such as beach retreat and beach width. The key parameter for the vulnerability assessment is the beach retreat. For its calculation two different approaches are used and compared. The first approach divides the eroded volume with the eroded depth and it is based on an empirical formula, derived for the Greek seas from the CCSEAWAVS project (Kokkinos et al, 2014), which links the eroded volume with JA parameter, a beach erosion predictor proposed by Jimenez (1993). The sediment fall velocity, the beach slope and the wave characteristics are the only necessary parameters to calculate JA. The second approach is based on the results derived from the numerical model Xbeach (Roelvink et al., 2009), which is an open source, state-of the-art, two-dimensional model including the hydrodynamic processes of short and long wave transformation, wave-induced setup, overwash, inundation, as well as the morphodynamic processes of bed load and suspended sediment transport, dune face avalanching, bed update and breaching. The results indicate that the area of Thrace is very prone to erosion at the eastern and western part of the study area, while the Island of Lesbos appears to have very low vulnerability. The application of this methodology with the two different approaches aims to generate useful information about the vulnerability to erosion, to examine the reliability of the empirical approach and to support studies for an adaptation policy to climate change. References: Jiménez, J.A., Sánchez-Arcilla, A., Stive, M.J.F., (1993), "Discussion on prediction of storm/normal beach profiles" Journal of Waterway Port, Coast. & Oc. Eng., 19(4): 466-468. Kokkinos D., Prinos P., Galiatsatou G., Jimenez J.A. (2014), "Estimation of Erosion Potential and Erosion Vulnerability Indices in the study sites" CCSEAWAVS, Report-Deliverable 4.2, THALES research project (In Greek) Mendoza, E.T. and Jiménez, J.A, (2009) "Regional geomorphic vulnerability analysis to storms for Catalan beaches", P. I. Civil Eng-Mar. En., 162(3): 127-135 Roelvink D., Reniers A., Van Dongeren A., De Vries J.T., McCall R., Lescinski J. (2009), "Modelling storm impacts on beaches, dunes and barrier islands", Coast. Eng., 56: 1133-1152

  5. Comparisons of auction mechanisms in a multiple unit setting: A consideration for restructuring electric power markets

    NASA Astrophysics Data System (ADS)

    Bernard, John Charles

    The objective of this study was to compare the performance of five single sided auctions that could be used in restructured electric power markets across different market sizes in a multiple unit setting. Auction selection would profoundly influence an industry over $200 billion in size in the United States, and the consequences of implementing an inappropriate mechanism would be great. Experimental methods were selected to analyze the auctions. Two rounds of experiments were conducted, the first testing the sealed offer last accepted offer (LAO) and first rejected offer (FRO), and the clock English (ENG) and sealed offer English (SOE) in markets of sizes two and six. The FRO, SOE, and ENG used the same pricing rule. Second round testing was on the LAO, FRO, and the nonuniform price multiple unit Vickrey (MUV) in markets of sizes two, four, and six. Experiments lasted 23 and 75 periods for rounds 1 and 2 respectively. Analysis of variance and contrast analysis were used to examine the data. The four performance measures used were price, efficiency, profits per unit, and supply revelation. Five basic principles were also assessed: no sales at losses, all low cost capacity should be offered and sold, no high cost capacity should sell, and the market should clear. It was expected group size and auction type would affect performance. For all performance measures, group size was a significant variable, with smaller groups showing poorer performance. Auction type was significant only for the efficiency performance measure, where clock auctions outperformed the others. Clock auctions also proved superior for the first four principles. The FRO performed poorly in almost all situations, and should not be a preferred mechanism in any market. The ENG was highly efficient, but expensive for the buyer. The SOE appeared superior to the FRO and ENG. The clock improves efficiency over the FRO while less information kept prices under the ENG. The MUV was superior in revealing costs, but performed less well in other categories. While concerns existed for all the mechanisms investigated, the commonly proposed LAO was the best option for restructured electric power markets.

  6. Very Low Frequency Seismo-Acoustic Noise Below the Sea Floor (0.2-10 Hz).

    DTIC Science & Technology

    1994-02-01

    applications see Stoffa et al., 1981 and Kappus et al., 1990). Fricke (1991, 1993) outlines a method for calculating the Radon transform on "ser...of Ocean Eng., OE-6, 50-58, 1981. Kappus , M. E. , A. J. Harding, and J. A. Orcutt, A comparison of tau-p transforms methods, Geophysics, 55, 1202

  7. HNF1(beta) is required for mesoderm induction in the Xenopus embryo.

    PubMed

    Vignali, R; Poggi, L; Madeddu, F; Barsacchi, G

    2000-04-01

    XHNF1(&bgr;) is a homeobox-containing gene initially expressed at the blastula stage in the vegetal part of the Xenopus embryo. We investigated its early role by functional ablation, through mRNA injection of an XHNF1(beta)/engrailed repressor fusion construct (XHNF1(beta)/EngR). Dorsal injections of XHNF1(beta)/EngR mRNA abolish dorsal mesoderm formation, leading to axial deficiencies; ventral injections disrupt ventral mesoderm formation without affecting axial development. XHNF1(beta)/EngR phenotypic effects specifically depend on the DNA-binding activity of its homeodomain and are fully rescued by coinjection of XHNF1(beta) mRNA. Vegetal injection of XHNF1(beta)/EngR mRNA blocks the mesoderm-inducing ability of vegetal explants. Both B-Vg1 and VegT maternal determinants trigger XHNF1(beta) expression in animal caps. XHNF1(beta)/EngR mRNA blocks B-Vg1-mediated, but not by eFGF-mediated, mesoderm induction in animals caps. However, wild-type XHNF1(beta) mRNA does not trigger Xbra expression in animal caps. We conclude that XHNF1(beta) function is essential, though not sufficient, for mesoderm induction in the Xenopus embryo.

  8. Bibliography on Cold Regions Science and Technology. Volume 44, Part 2

    DTIC Science & Technology

    1990-01-01

    eng441404 Lewis icing research tunnel t1 989 , 13p., eng 44-792 um and companion elements in lichen heath near Baker Khodnkov, V. Two-dimensional...elements in lichen heath near Baker Lindstrm, G. Mountains t1 9 88 . p.21-22. chi] 44-631 Lake N.W.T. (1989. 42p.. eng] 44-2114 Modelling extreme...elements in lichen heath sear Baker 10th, Tokyo, Dec. 8-9, 1987 Nixn, J.F. Lake N.W.T. E11989. 482p., engl 44-2114 Proceedings of the NIPR Symposium on

  9. Uteroplacental arterio-venous difference in soluble VEGFR-1 (sFlt-1), but not in soluble endoglin concentrations in preeclampsia.

    PubMed

    Paasche Roland, M C; Lorentzen, B; Godang, K; Henriksen, T

    2012-03-01

    The aim was to determine plasma levels of sFlt-1 and sEng on the arterial and venous side of the uteroplacental circulation in preeclamptic patients and healthy controls. Preeclamptic patients had higher arterial concentrations than controls of sFlt-1 (17,450 vs. 5055 pg/ml, p = 0.003) and sEng (68.7 vs. 28.7 ng/ml, p = 0.003). In the preclampsia group sFlt-1 was higher in the uterine vein than in the radial artery (22,450 vs. 17,450 pg/ml, p = 0.005). We found no gradient for sEng. Our results support the hypothesis that excess sFlt-1 at least partly originates in placenta, while excess sEng appears to have a different origin. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Transient Simulation of Accumulating Particle Deposition in Pipe Flow

    NASA Astrophysics Data System (ADS)

    Hewett, James; Sellier, Mathieu

    2015-11-01

    Colloidal particles that deposit in pipe systems can lead to fouling which is an expensive problem in both the geothermal and oil & gas industries. We investigate the gradual accumulation of deposited colloids in pipe flow using numerical simulations. An Euler-Lagrangian approach is employed for modelling the fluid and particle phases. Particle transport to the pipe wall is modelled with Brownian motion and turbulent diffusion. A two-way coupling exists between the fouled material and the pipe flow; the local mass flux of depositing particles is affected by the surrounding fluid in the near-wall region. This coupling is modelled by changing the cells from fluid to solid as the deposited particles exceed each local cell volume. A similar method has been used to model fouling in engine exhaust systems (Paz et al., Heat Transfer Eng., 34(8-9):674-682, 2013). We compare our deposition velocities and deposition profiles with an experiment on silica scaling in turbulent pipe flow (Kokhanenko et al., 19th AFMC, 2014).

  11. Alignment of leading-edge and peak-picking time of arrival methods to obtain accurate source locations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Roussel-Dupre, R.; Symbalisty, E.; Fox, C.

    2009-08-01

    The location of a radiating source can be determined by time-tagging the arrival of the radiated signal at a network of spatially distributed sensors. The accuracy of this approach depends strongly on the particular time-tagging algorithm employed at each of the sensors. If different techniques are used across the network, then the time tags must be referenced to a common fiducial for maximum location accuracy. In this report we derive the time corrections needed to temporally align leading-edge, time-tagging techniques with peak-picking algorithms. We focus on broadband radio frequency (RF) sources, an ionospheric propagation channel, and narrowband receivers, but themore » final results can be generalized to apply to any source, propagation environment, and sensor. Our analytic results are checked against numerical simulations for a number of representative cases and agree with the specific leading-edge algorithm studied independently by Kim and Eng (1995) and Pongratz (2005 and 2007).« less

  12. Computationally efficient simulation of unsteady aerodynamics using POD on the fly

    NASA Astrophysics Data System (ADS)

    Moreno-Ramos, Ruben; Vega, José M.; Varas, Fernando

    2016-12-01

    Modern industrial aircraft design requires a large amount of sufficiently accurate aerodynamic and aeroelastic simulations. Current computational fluid dynamics (CFD) solvers with aeroelastic capabilities, such as the NASA URANS unstructured solver FUN3D, require very large computational resources. Since a very large amount of simulation is necessary, the CFD cost is just unaffordable in an industrial production environment and must be significantly reduced. Thus, a more inexpensive, yet sufficiently precise solver is strongly needed. An opportunity to approach this goal could follow some recent results (Terragni and Vega 2014 SIAM J. Appl. Dyn. Syst. 13 330-65 Rapun et al 2015 Int. J. Numer. Meth. Eng. 104 844-68) on an adaptive reduced order model that combines ‘on the fly’ a standard numerical solver (to compute some representative snapshots), proper orthogonal decomposition (POD) (to extract modes from the snapshots), Galerkin projection (onto the set of POD modes), and several additional ingredients such as projecting the equations using a limited amount of points and fairly generic mode libraries. When applied to the complex Ginzburg-Landau equation, the method produces acceleration factors (comparing with standard numerical solvers) of the order of 20 and 300 in one and two space dimensions, respectively. Unfortunately, the extension of the method to unsteady, compressible flows around deformable geometries requires new approaches to deal with deformable meshes, high-Reynolds numbers, and compressibility. A first step in this direction is presented considering the unsteady compressible, two-dimensional flow around an oscillating airfoil using a CFD solver in a rigidly moving mesh. POD on the Fly gives results whose accuracy is comparable to that of the CFD solver used to compute the snapshots.

  13. Producer-retailer integrated EMQ system with machine breakdown, rework failures, and a discontinuous inventory issuing policy.

    PubMed

    Chiu, Singa Wang; Chen, Shin-Wei; Chiu, Yuan-Shyi Peter; Li, Ting-Wei

    2016-01-01

    This study develops two extended economic manufacturing quantity (EMQ)-based models with a discontinuous product issuing policy, random machine breakdown, and rework failures. Various real conditions in production processes, end-product delivery, and intra-supply chains such as a producer-retailer integrated scheme are examined. The first model incorporates a discontinuous multi-delivery policy into a prior work (Chiu et al. in Proc Inst Mech Eng B J Eng 223:183-194, 2009) in lieu of their continuous policy. Such an enhanced model can address situations in supply chain environments, where finished products are transported to outside retail stores (or customers). The second model further combines retailer's stock holding costs into the first model. This extended EMQ model is applicable in situations in present-day manufacturing firms where finished products are distributed to company's own retail stores (or regional sales offices) and stocked there for sale. Two aforementioned extended EMQ models are investigated, respectively. Mathematical modeling along with iterative algorithms are employed to derive the optimal production run times that minimize the expected total system costs, including the costs incurred in production units, transportation, and retail stores, for these integrated EMQ systems. Numerical examples are provided to demonstrate the practical application of the research results.

  14. Cadaverous Particles and Infection in Injured Man,

    DTIC Science & Technology

    1993-01-01

    reported that, by and radiographically confirmed inhalation injury and this method, the diagnosis of necrotizing fasciitis was there has been a...tially fatal necrotizing fasciitis : The use of frozen-section burn pathogen? Antibiot Chemother 1989; 42: 103-108. biopsy. N EngI J Med 1984; 310: 1689

  15. From virtual clustering analysis to self-consistent clustering analysis: a mathematical study

    NASA Astrophysics Data System (ADS)

    Tang, Shaoqiang; Zhang, Lei; Liu, Wing Kam

    2018-03-01

    In this paper, we propose a new homogenization algorithm, virtual clustering analysis (VCA), as well as provide a mathematical framework for the recently proposed self-consistent clustering analysis (SCA) (Liu et al. in Comput Methods Appl Mech Eng 306:319-341, 2016). In the mathematical theory, we clarify the key assumptions and ideas of VCA and SCA, and derive the continuous and discrete Lippmann-Schwinger equations. Based on a key postulation of "once response similarly, always response similarly", clustering is performed in an offline stage by machine learning techniques (k-means and SOM), and facilitates substantial reduction of computational complexity in an online predictive stage. The clear mathematical setup allows for the first time a convergence study of clustering refinement in one space dimension. Convergence is proved rigorously, and found to be of second order from numerical investigations. Furthermore, we propose to suitably enlarge the domain in VCA, such that the boundary terms may be neglected in the Lippmann-Schwinger equation, by virtue of the Saint-Venant's principle. In contrast, they were not obtained in the original SCA paper, and we discover these terms may well be responsible for the numerical dependency on the choice of reference material property. Since VCA enhances the accuracy by overcoming the modeling error, and reduce the numerical cost by avoiding an outer loop iteration for attaining the material property consistency in SCA, its efficiency is expected even higher than the recently proposed SCA algorithm.

  16. Medical History in the Hellenic Journal of Nuclear Medicine.

    PubMed

    Otte, Andreas

    2017-01-01

    The Hellenic Journal of Nuclear Medicine is about to celebrate its 20th anniversary end of 2017. On board of the editorial team since 2003, this journal has influenced me like a good friend over the many past years. From time to time, the journal has published interesting and valuable historical notes. They show that nuclear medicine has a history and that medicine is its basis. They also teach us today, and some of the ancient perspectives and approaches are still valid. The reader of HJNM may be interested in these historical contributions, as they are timeless. Therefore, it was our idea to summarize these in the following pages. Where there is a link to the free article, this is noted. Upon opening all articles, you will find out that these are a book or so of its own. In thanks to the editor-in-chief of the Journal for his continuing support on the historical section. Below we refer to the historical papers of the Journal: History of Nuclear Medicine. Nuclear Medicine and History of Science and Philosophy: Atomic Theory of the Matter. G.N. Sfakianakis, 2001; 4(3); 155-60. Editorial. Pioneers of nuclear medicine, Madame Curie. P.C. Grammaticos. 2004; 7(1); 29-30. http://nuclmed.web.auth.gr/ magazine/eng/jan04/editorial.htm Editor's note. Hippocrates' Oath. The editor. 2004; 7(1); 31. Editorial. Useful known and unknown views of the father of modern medicine, Hippocrates and his teacher Democritus. P. Grammaticos, A. Diamantis. 2008; 11(1): 2-4. http://nuclmed.web.auth.gr/magazine/eng/jan08/2.pdf Special Article. The contribution of Maria Sklodowska-Curie and Pierre Curie to Nuclear and Medical Physics. A hundred and ten years after the discovery of radium. A. Diamantis, E. Magiorkinis, 2008; 11(1): 33-8. http://nuclmed.web.auth.gr/magazine/ eng/jan08/33.pdf Brief Historical Review. Lymphatic system and lymphoscintigraphy. P. Valsamaki. 2009; 12(1): 87-89. http://nuclmed.web. auth.gr/magazine/eng/jan09/89.pdf (In Greek) Historical Review. The philosophic and biological views of the "atomic" philosophers, Leucippus and Democritus. E. Magiorkinis. A. Beloukas, A. Diamantis. 2010; 13(2): 111-117. http://nuclmed.web.auth.gr/magazine/eng/may10/9.pdf Correspondence. Neuroimaging in mild traumatic brain injury and M. Ravel's injury. A. Otte. 2012; 15(1): 76. http://nuclmed. web.auth.gr/magazine/eng/jan12/3.pdf Selected Brief Contributions. The "atomic theory" of Leucippus, and its impact on medicine before Hippocrates. G. Tsoucalas, K. Laios et al. 2013; 16(1): 68-9. http://nuclmed.web.auth.gr/magazine/eng/jan13/72.pdf Selected Brief Contributions. Computed tomography alone reveals the secrets of ancient mummies in medical archaeology. A. Otte, T. Thieme et al. 2013; 16(2): 148-9. http://nuclmed.web.auth.gr/magazine/eng/may13/70.pdf Editorial. The timeless influence of Hippocratic ideas on diet, salicylates and personalized medicine. T.C. Karagiannis. 2014; 17(1): 2-6. http://nuclmed.web.auth.gr/magazine/eng/jan14/1.pdf Historical Article. The physician who first applied radiotherapy, Victor Despeignes, on 1896. M. Sgantzos, G. Tsoucalas et al. 2014; 17(1): 45-6. http://nuclmed.web.auth.gr/magazine/eng/jan14/11.pdf Original Articles. Medical practice applied in the ancient Asclepeion in Kos island. M. Mironidou-Tzouveleki, P.M. Tzitzis. 2014; 17(3): 167-70. http://www.nuclmed.web.auth.gr/magazine/eng/sept14/3.pdf Special Historical Article. How a tertiary medical nuclear medicine department at the Himalayan area in India can be established and function in an exemplary manner. Basic rules revisited. V.K. Dhingra, S. Saini et al. 2015; 18(3): 252-6. http:// nuclmed.web.auth.gr/magazine/eng/sept15/13.pdf Historical and Commentary Note. Johann Sebastian Bach's "Goldberg variations" to treat insomnia from renal lithiasis pain. Sleep research in Nuclear Medicine. A. Otte. 2016; 19(1): 13-4. http://nuclmed.web.auth.gr/magazine/eng/jan16/06.pdf Historical Review. The first medical ethics and deontology in Europe as derived from Greek mythology. M.K. Konstantinidou. 2016; 19(2): 155-8.http://nuclmed.web.auth.gr/magazine/eng/may16/11.pdf Historical-Technical Article. The beginning of using X-rays and the evolution of equipment for the treatment of ocular cancer. K. Laios, M. Zozoglou. 2017; 20(1): Ahead of print. And hopefully many more to follow!

  17. Biological and Catalytic Conversion of Sugars and Lignin Publications |

    Science.gov Websites

    mechanism of free and cellulosomal enzyme synergy, ACS Sustainable Chem. Eng. Evaluation of clean Free Energy, J. Amer. Chem. Soc. Process Design and Economics for the Conversion of Lignocellulosic Processive Cellulase with Multiple Absolute Binding Free Energy Methods, J. Biol. Chem. Optimizing Nucleus

  18. Main principles and technique of electronystagmography (a brief survey of the literature)

    NASA Technical Reports Server (NTRS)

    Tanchev, K. S.

    1980-01-01

    Electronystagmography (ENG) is one of the modern methods for objective recording of nystagmus, its quantitative and qualitative assessment. It is used more and more often in clinical practice. A brief review of the history of recording of nystagmus and a survey of the relevant literature is presented.

  19. [The role of international comparison in surveying divorce trends].

    PubMed

    Cseh-szombathy, L

    1982-04-01

    In this study, the main survey methods and approaches to analyzing data on divorce in different countries are described. Some problems concerning the international comparability of divorce statistics are examined, and the value of international comparative studies for identifying common factors affecting divorce is stressed. (summary in ENG, RUS)

  20. Flow Visualization Study of Natural Convection from a Heated Protrusion in a Liquid Filled Rectangular Enclosure.

    DTIC Science & Technology

    1983-12-01

    PROPOSED SOLUTIONS Many papers have been published outlining alternative methods of thermally controlling microelectronic devices. Hannemann [3] describes...Workshop, NSF Grant ENG-7701297, Directions of Heat Transfer in Electronic Equipment, Fy R. C. Chu, 1977. 3. Hannemann , R., "Electronic System Thermal

  1. Internal friction between fluid particles of MHD tangent hyperbolic fluid with heat generation: Using coefficients improved by Cash and Karp

    NASA Astrophysics Data System (ADS)

    Salahuddin, T.; Khan, Imad; Malik, M. Y.; Khan, Mair; Hussain, Arif; Awais, Muhammad

    2017-05-01

    The present work examines the internal resistance between fluid particles of tangent hyperbolic fluid flow due to a non-linear stretching sheet with heat generation. Using similarity transformations, the governing system of partial differential equations is transformed into a coupled non-linear ordinary differential system with variable coefficients. Unlike the current analytical works on the flow problems in the literature, the main concern here is to numerically work out and find the solution by using Runge-Kutta-Fehlberg coefficients improved by Cash and Karp (Naseer et al., Alexandria Eng. J. 53, 747 (2014)). To determine the relevant physical features of numerous mechanisms acting on the deliberated problem, it is sufficient to have the velocity profile and temperature field and also the drag force and heat transfer rate all as given in the current paper.

  2. Method of improving superconducting qualities of fabricated constructs by shock preprocessing of precursor materials

    DOEpatents

    Nellis, William J.; Maple, M. Brian

    1992-01-01

    Disclosed is a method of improving the physical properties of superconducting materials which comprises: a. applying a high strain rate deformation to said materi The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the U.S. Department of Energy and the University of California, for the operation of Lawrence Livermore National Laboratory.

  3. Restructuring Graduate Engineering Education: The M.Eng. Program at Cornell.

    ERIC Educational Resources Information Center

    Cady, K. Bingham; And Others

    1988-01-01

    Discusses the restructuring of the graduate program to accommodate emerging fields in engineering. Notes half of the graduate degrees Cornell grants each year are M.Eng. degrees. Offers 12 specialties: aerospace, agriculture, chemical, civil, electrical, mechanical and nuclear engineering; computer science, engineering physics; geological…

  4. Full Eulerian simulations of biconcave neo-Hookean particles in a Poiseuille flow

    NASA Astrophysics Data System (ADS)

    Sugiyama, Kazuyasu; , Satoshi, II; Takeuchi, Shintaro; Takagi, Shu; Matsumoto, Yoichiro

    2010-03-01

    For a given initial configuration of a multi-component geometry represented by voxel-based data on a fixed Cartesian mesh, a full Eulerian finite difference method facilitates solution of dynamic interaction problems between Newtonian fluid and hyperelastic material. The solid volume fraction, and the left Cauchy-Green deformation tensor are temporally updated on the Eulerian frame, respectively, to distinguish the fluid and solid phases, and to describe the solid deformation. The simulation method is applied to two- and three-dimensional motions of two biconcave neo-Hookean particles in a Poiseuille flow. Similar to the numerical study on the red blood cell motion in a circular pipe (Gong et al. in J Biomech Eng 131:074504, 2009), in which Skalak’s constitutive laws of the membrane are considered, the deformation, the relative position and orientation of a pair of particles are strongly dependent upon the initial configuration. The increase in the apparent viscosity is dependent upon the developed arrangement of the particles. The present Eulerian approach is demonstrated that it has the potential to be easily extended to larger system problems involving a large number of particles of complicated geometries.

  5. A randomized clinical trial of the effect of intensive versus non-intensive counselling on discontinuation rates due to bleeding disturbances of three long-acting reversible contraceptives.

    PubMed

    Modesto, Waleska; Bahamondes, M Valeria; Bahamondes, Luis

    2014-07-01

    Does intensive counselling before insertion and throughout the first year of use have any influence on discontinuation rates due to unpredictable menstrual bleeding in users of three long-acting reversible contraceptives (LARCs)? Intensive counselling had a similar effect to routine counselling in terms of discontinuation rates due to unpredictable menstrual bleeding in new users of the contraceptives. Contraceptive efficacy and satisfaction rates are very high with LARCs, including the etonogestrel (ENG)-releasing implant, the levonorgestrel-releasing intrauterine system (LNG-IUS) and the TCu380A intrauterine device (IUD). However, unpredictable menstrual bleeding constitutes the principal reason for premature discontinuation, particularly in the cases of the ENG-implant and the LNG-IUS. A randomized clinical trial was conducted between 2011 and 2013, and involved 297 women: 98 ENG-implant users, 99 LNG-IUS users and 100 TCu380A IUD users. Women accepting each contraceptive method were randomized into two groups after the women chose their contraceptive method. Group I received routine counselling at the clinic, including information on safety, efficacy and side effects, as well as what to expect regarding bleeding disturbances. Group II received 'intensive counselling'. In addition to the information provided to those in Group I, these women also received leaflets on their chosen method and were seen by the same three professionals, the most experienced at the clinic, throughout the year of follow-up. These three professionals went over all the information provided at each consultation. Women in both groups were instructed to return to the clinic after 45 (±7) days and at 6 and 12 (±1) months after insertion. They were instructed to record all bleeding episodes on a menstrual calendar specifically provided for this purpose. Additionally, satisfaction with the method was evaluated by a questionnaire completed by the women after 12 months of use of the contraceptive method. There were no significant differences between the intensive and routine counselling groups on the discontinuation rates due to unpredictable menstrual bleeding of the three contraceptives under evaluation. The 1-year cumulative discontinuation rates due to menstrual bleeding irregularities were 2.1, 2.7 and 4.0% and the continuation rates were 82.6, 81.0 and 73.2%, for the ENG-implant, the LNG-IUS or the TCu380A IUD users, respectively. The main reasons for discontinuation of the methods were weight gain in users of the ENG-implant and expulsion of the TCu380A. The main limitations are that we cannot assure generalization of the results to another settings and that the routine counselling provided by our counsellors may already be appropriate for the women attending the clinic and so consequently intensive counselling including written leaflets was unable to influence the premature discontinuation rate due to unpredictable menstrual bleeding. Additionally, counselling could discourage some women from using the LARC methods offered in the study and consequently those women may have decided on other contraceptives. Routine counselling may be sufficient for many women to help reduce premature discontinuation rates and improve continuation rates and user satisfaction among new users of LARC methods. The trial was registered at clinicaltrials.gov (NCT01392157). The study was partially funded by the Fundação de Apoio a Pesquisa do Estado de São Paulo (FAPESP) grant # 2012/01379-0, the Brazilian National Research Council (CNPq) grant #573747/2008-3 and by Merck (MSD), Brazil under an unrestricted grant. The LNG-IUS were donated by the International Contraceptive Access Foundation (ICA) and the copper IUD by Injeflex, São Paulo, Brazil. L.B. has occasionally served on the Board of MSD, Bayer and Vifor.

  6. Developing a Hybrid Virtualization Platform Design for Cyber Warfare Training and Education

    DTIC Science & Technology

    2010-06-01

    CYBER WARFARE TRAINING AND EDUCATION THESIS Kyle E. Stewart 2nd...Government. AFIT/GCE/ENG/10-06 DEVELOPING A HYBRID VIRTUALIZATION PLATFORM DESIGN FOR CYBER WARFARE TRAINING...APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. AFIT/GCE/ENG/10-06 DEVELOPING A HYBRID VIRTUALIZATION PLATFORM DESIGN FOR CYBER WARFARE

  7. Assessment of Attack Reconnaissance Helicopter (ARH) Machining, Cutting and Drilling Operations

    DTIC Science & Technology

    2006-09-29

    Date: June 20, 2006 Name Organization Email Jim Corwin Consultant JCAI/Army corwinj@att.net Cindy Fenny Process Engineer Bell / Process Engineering...bellhelicopter.textron.com Cindy Fenny Process Eng 817-280-2549 cfenny@bellhelicopter.textron.com Max Trull Process Eng 817-280-2678 mtrull@bellhelicopter.textron.com Ron

  8. 33 CFR 325.5 - Forms of permits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) DA permits under this regulation will be in the form of individual permits or general permits. The basic format shall be ENG Form 1721, DA Permit (Appendix A). (2) The general conditions included in ENG... be required. (2) Nationwide permits. Nationwide permits are a type of general permit and represent DA...

  9. Safety issues in cultural heritage management and critical infrastructures management

    NASA Astrophysics Data System (ADS)

    Soldovieri, Francesco; Masini, Nicola; Alvarez de Buergo, Monica; Dumoulin, Jean

    2013-12-01

    This special issue is the fourth of its kind in Journal of Geophysics and Engineering , containing studies and applications of geophysical methodologies and sensing technologies for the knowledge, conservation and security of products of human activity ranging from civil infrastructures to built and cultural heritage. The first discussed the application of novel instrumentation, surface and airborne remote sensing techniques, as well as data processing oriented to both detection and characterization of archaeological buried remains and conservation of cultural heritage (Eppelbaum et al 2010). The second stressed the importance of an integrated and multiscale approach for the study and conservation of architectural, archaeological and artistic heritage, from SAR to GPR to imaging based diagnostic techniques (Masini and Soldovieri 2011). The third enlarged the field of analysis to civil engineering structures and infrastructures, providing an overview of the effectiveness and the limitations of single diagnostic techniques, which can be overcome through the integration of different methods and technologies and/or the use of robust and novel data processing techniques (Masini et al 2012). As a whole, the special issue put in evidence the factors that affect the choice of diagnostic strategy, such as the material, the spatial characteristics of the objects or sites, the value of the objects to be investigated (cultural or not), the aim of the investigation (knowledge, conservation, restoration) and the issues to be addressed (monitoring, decay assessment). In order to complete the overview of the application fields of sensing technologies this issue has been dedicated to monitoring of cultural heritage and critical infrastructures to address safety and security issues. Particular attention has been paid to the data processing methods of different sensing techniques, from infrared thermography through GPR to SAR. Cascini et al (2013) present the effectiveness of a remote sensing technique known as synthetic aperture radar at medium (ERS-ENVISAT) and high (COSMO-SkyMed) resolution for the detection and monitoring of facilities (i.e. buildings/infrastructures) in subsiding areas. In this paper, the results are presented with reference to a densely urbanized flat area in southern Italy, so as to show how the appropriate use of DInSAR data at different scales can help in the detection and monitoring of damageable facilities. Battaglini et al (2013) deal with a methodology for accurately estimating the behaviour of a landfill system in terms of biogas release to the atmosphere. In addition, the link between the flux measurements of biogas release and thermal anomalies detected by infrared radiometry is also discussed. The main benefit of the approach presented is a significant increase to the energy recovered from the landfill site by means of an optimal collection of biogas, which implies a reduction of the total anthropogenic methane originated from the disposal of waste. Dumoulin et al (2013) present an interesting technological solution for the thermal monitoring of a bridge deck. The system integrates an uncooled infrared camera with other sensors (i.e. a weather station and a GPS) and the detection of the inner structure of the deck is achieved by pulse phase thermography (PPT) and principal component thermography (PCT) approaches, so that a first characterization of the inner structure of the deck is proposed. Pappalardo et al (2013) show the advanced versions of the BSC-XRF (beam stability controlled—x-ray fluorescence) and PIXE-alpha (particle induced x-ray emission, using low energy alpha particles) portable spectrometers, developed at the Landis laboratory of the LNS-INFN and IBAM-CNR in Catania, Italy. Several analysis results are reviewed for data from various Sicilian sites and recent data, about the Via Capuana settlement in Licodia Eubea, are also presented and discussed for the first time. Drdácký and Slížková (2013) present two methods as peeling tests, also known as the 'Scotch tape' method, and surface water uptake measurements, using a digitized micro-tube for assessing material characteristics and consolidation effects on historic stone and mortar. Both methods are reviewed by pointing out both the advantages and the drawbacks. Solimene et al (2013) present a novel data processing technique based on the inverse electromagnetic scattering for small and weak target detection and localization. They start from the idea of applying a two-stage MUSIC algorithm. In the first stage strong scatterers are detected. Then, information concerning their number and location is employed to detect and localize the weak scatterers. The role of an adequate scattering model is emphasized to drastically improve detection performance in realistic scenarios. Kadioglu et al (2013) deal with the exploitation of ground penetrating radar, enhanced by advanced data processing based on microwave tomography, for the detection and the assessment of structural damage affecting foundation healthiness, of significant relevance for safety management in cultural heritage. An interesting case of the effectiveness of the joint procedure is shown by processing measurements collected during a survey at the Great Mosque of Ilyas Bey, one of the most important cultural heritage features from ancient Miletos-Iona in Soke Aydin, Turkey. Finally, Nordebo et al (2013) provide an interesting analysis of the optimal accuracy and resolution in electrical impedance tomography (EIT), based on the Cramer-Rao lower bound. This study is very important in the set up and analysis of the regularization strategies for the linearized problem at hand. References Battaglini R, Raco B and Scozzari A 2013 Effective monitoring of landfills: flux measurements and thermography enhance efficiency and reduce environmental impact J. Geophys. Eng. 10 064002 Cascini L, Peduto D, Reale D, Arena L, Ferlisi S, Verde S and Fornaro G 2013 Detection and monitoring of facilities exposed to subsidence phenomena via past and current generation SAR sensors J. Geophys. Eng. 10 064001 Drdácký M and Slížková Z 2013 Enhanced affordable methods for assessing material characteristics and consolidation effects on stone and mortar J. Geophys. Eng. 10 064005 Dumoulin J, Crinière A and Averty R 2013 The detection and thermal characterization of the inner structure of the 'Musmeci' bridge deck by infrared thermography monitoring J. Geophys. Eng. 10 064003 Eppelbaum L, Masini N and Soldovieri F 2010 Near surface geophysics for the study and the management of historical resources J. Geophys. Eng. 7 E01 Kadioglu S, Kadioglu Y K, Catapano I and Soldovieri F 2013 Ground penetrating radar and microwave tomography for the safety management of a cultural heritage site: Miletos Ilyas Bey Mosque (Turkey) J. Geophys. Eng. 10 064007 Masini N and Soldovieri F 2011 Integrated non-invasive sensing techniques and geophysical methods for the study and conservation of architectural, archaeological and artistic heritage J. Geophys. Eng. 8 E01 Masini N, Soldovieri F, Alvarez de Buergo M and Dumoulin J 2012 Cultural heritage and civil engineering J. Geophys. Eng. 9 E01 Nordebo S, Gustafsson M, Nilsson B, Sjöden T and Soldovieri F 2013 Fisher information analysis in electrical impedance tomography J. Geophys. Eng. 10 064008 Pappalardo L, Romano F P, Bracchitta D, Massimino A, Palio O and Rizzo F 2013 Obsidian provenance determination using the beam stability controlled BSC-XRF and the PIXE-alpha portable spectrometers of the LANDIS laboratory: the case of the Via Capuana settlement in Licodia Eubea (Sicily) J. Geophys. Eng. 10 064004 Solimene R, Leone G and Dell'Aversano A 2013 MUSIC algorithms for rebar detection J. Geophys. Eng. 10 064006

  10. Mutation in BMPR2 Promoter: A ‘Second Hit’ for Manifestation of Pulmonary Arterial Hypertension?

    PubMed Central

    Ehlken, Nicola; Fischer, Christine; Lichtblau, Mona; Grünig, Ekkehard; Hinderhofer, Katrin

    2015-01-01

    Background Hereditary pulmonary arterial hypertension (HPAH) can be caused by autosomal dominant inherited mutations of TGF-β genes, such as the bone morphogenetic protein receptor 2 (BMPR2) and Endoglin (ENG) gene. Additional modifier genes may play a role in disease manifestation and severity. In this study we prospectively assessed two families with known BMPR2 or ENG mutations clinically and genetically and screened for a second mutation in the BMPR2 promoter region. Methods We investigated the BMPR2 promoter region by direct sequencing in two index-patients with invasively confirmed diagnosis of HPAH, carrying a mutation in the BMPR2 and ENG gene, respectively. Sixteen family members have been assessed clinically by non-invasive methods and genetically by direct sequencing. Results In both index patients with a primary BMPR2 deletion (exon 2 and 3) and Endoglin missense variant (c.1633G>A, p.(G545S)), respectively, we detected a second mutation (c.-669G>A) in the promoter region of the BMPR2 gene. The index patients with 2 mutations/variants were clinically severely affected at early age, whereas further family members with only one mutation had no manifest HPAH. Conclusion The finding of this study supports the hypothesis that additional mutations may lead to an early and severe manifestation of HPAH. This study shows for the first time that in the regulatory region of the BMPR2 gene the promoter may be important for disease penetrance. Further studies are needed to assess the incidence and clinical relevance of mutations of the BMPR2 promoter region in a larger patient cohort. PMID:26167679

  11. F-111D, DT and E Evaluation of Environmental Control, Airframe, Flight Control, and Secondary Power Subsystems. Appendix 1

    DTIC Science & Technology

    1973-12-01

    Temperature, oil tank L/H eng Pressure, oil tank breather L/H eng Pressure, P&D valve primary fuel outlet L/H eng ^ , ^ Pressure, P&D valve ...T o -J -’ -« ^ u. >- *-• »- r C »- x c- r^ ► t- k-j vT (M r J ^ uT -- if J c t -r j a a •■ t xT tf1 l^ «T v.’ 0...f .t -» J -5 -t -* * J JJJJ^^-J-* i! ir LT ir ir i tr U" U" L U IT IT tf1 t. b (^ IT tf IT

  12. CTN summary of DSREDS, EDCARS, EDMICS CALS readiness testing. [Computer-aided Acquisition and Logistic Support (CALS) CALS Test Network (CTN), Digital Storage Retrieval Eng. Data System (DSREDS), Eng. Data Computer Assisted Retrieval System (EDCARS), Eng. Data Management Information and Control System (EDMICS)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mitschkowetz, N.; Vickers, D.L.

    This report provides a summary of the Computer-aided Acquisition and Logistic Support (CALS) Test Network (CTN) Laboratory Acceptance Test (LAT) and User Application Test (UAT) activities undertaken to evaluate the CALS capabilities being implemented as part of the Department of Defense (DOD) engineering repositories. Although the individual testing activities provided detailed reports for each repository, a synthesis of the results, conclusions, and recommendations is offered to provide a more concise presentation of the issues and the strategies, as viewed from the CTN perspective.

  13. The role of continuity in residual-based variational multiscale modeling of turbulence

    NASA Astrophysics Data System (ADS)

    Akkerman, I.; Bazilevs, Y.; Calo, V. M.; Hughes, T. J. R.; Hulshoff, S.

    2008-02-01

    This paper examines the role of continuity of the basis in the computation of turbulent flows. We compare standard finite elements and non-uniform rational B-splines (NURBS) discretizations that are employed in Isogeometric Analysis (Hughes et al. in Comput Methods Appl Mech Eng, 194:4135 4195, 2005). We make use of quadratic discretizations that are C 0-continuous across element boundaries in standard finite elements, and C 1-continuous in the case of NURBS. The variational multiscale residual-based method (Bazilevs in Isogeometric analysis of turbulence and fluid-structure interaction, PhD thesis, ICES, UT Austin, 2006; Bazilevs et al. in Comput Methods Appl Mech Eng, submitted, 2007; Calo in Residual-based multiscale turbulence modeling: finite volume simulation of bypass transition. PhD thesis, Department of Civil and Environmental Engineering, Stanford University, 2004; Hughes et al. in proceedings of the XXI international congress of theoretical and applied mechanics (IUTAM), Kluwer, 2004; Scovazzi in Multiscale methods in science and engineering, PhD thesis, Department of Mechanical Engineering, Stanford Universty, 2004) is employed as a turbulence modeling technique. We find that C 1-continuous discretizations outperform their C 0-continuous counterparts on a per-degree-of-freedom basis. We also find that the effect of continuity is greater for higher Reynolds number flows.

  14. Local finite element enrichment strategies for 2D contact computations and a corresponding post-processing scheme

    NASA Astrophysics Data System (ADS)

    Sauer, Roger A.

    2013-08-01

    Recently an enriched contact finite element formulation has been developed that substantially increases the accuracy of contact computations while keeping the additional numerical effort at a minimum reported by Sauer (Int J Numer Meth Eng, 87: 593-616, 2011). Two enrich-ment strategies were proposed, one based on local p-refinement using Lagrange interpolation and one based on Hermite interpolation that produces C 1-smoothness on the contact surface. Both classes, which were initially considered for the frictionless Signorini problem, are extended here to friction and contact between deformable bodies. For this, a symmetric contact formulation is used that allows the unbiased treatment of both contact partners. This paper also proposes a post-processing scheme for contact quantities like the contact pressure. The scheme, which provides a more accurate representation than the raw data, is based on an averaging procedure that is inspired by mortar formulations. The properties of the enrichment strategies and the corresponding post-processing scheme are illustrated by several numerical examples considering sliding and peeling contact in the presence of large deformations.

  15. 32 CFR 644.458 - Documenting lease terminations and restoration settlements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... release from the lessor as of the date the premises are vacated and Government improvements removed. Releases will also be obtained as indicated in § 644.462. (a) Form to be used. Releases will be executed, in triplicate, on ENG Form 232-R, Release (Corporation), or ENG Form 231, Release (Partnership...

  16. Wireless Sensor Network Applications for the Combat Air Forces

    DTIC Science & Technology

    2006-06-13

    WIRELESS SENSOR NETWORK APPLICATIONS FOR THE COMBAT AIR FORCES GRADUATE RESEARCH PROJECT...Government. AFIT/IC4/ENG/06-05 WIRELESS SENSOR NETWORK APPLICATIONS FOR THE COMBAT AIR FORCES GRADUATE RESEARCH PROJECT Presented to the...Major, USAF June 2006 APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED AFIT/IC4/ENG/06-05 WIRELESS SENSOR NETWORK APPLICATIONS

  17. Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression.

    PubMed

    Gilbert, Jeffrey S; Gilbert, Sara A B; Arany, Marietta; Granger, Joey P

    2009-02-01

    Recent clinical studies indicate that an excess of angiostatic factors, such as soluble endoglin (sEng), is related to the occurrence of preeclampsia. Although recent clinical studies report that sEng is increased in preeclamptic women, the mechanisms underlying its overexpression remain unclear. Evidence suggests that hypoxia and induction of heme oxygenase-1 have opposing effects on sEng expression, the former stimulatory and the latter inhibitory. Hence, we hypothesized that placental ischemia because of reduced uterine perfusion pressure (RUPP) in the pregnant rat would increase sEng expression and decrease heme oxygenase-1. Mean arterial pressure was obtained via arterial catheter, and serum and placental proteins were measured by Western blot. Mean arterial pressure was increased (132+/-3 mm Hg versus 102+/-2 mm Hg; P<0.001), and fetal (2.35+/-0.05 g versus 1.76+/-0.08 g; P<0.001) and placental weight were decreased (0.47+/-0.04 g versus 0.58+/-0.03 g; P<0.01) in the RUPP compared with normal pregnant controls. Serum sEng (0.10+/-0.02 arbitrary pixel units [apu] versus 0.05+/-0.01 apu; P<0.05) and placental endoglin (4.7+/-2.3 apu versus 1.45+/-0.42 apu; P<0.05) were increased along with placental hypoxia inducible factor-1 alpha (1.42+/-0.25 apu versus 0.68+/-0.09 apu; P<0.05) expression in the RUPP versus the normal pregnant dams. Placental HO-1 (1.4+/-0.3 apu versus 2.5+/-0.1 apu; P<0.05) expression decreased in the RUPP compared with normal pregnant dams. The present findings support our hypothesis that placental ischemia because of RUPP increases the expression of sEng and shifts the balance of angiogenic factors in the maternal circulation toward an angiostatic state. The present study provides further evidence that placental ischemia is a strong in vivo stimulus of angiostatic factors during pregnancy.

  18. ARC: An open-source library for calculating properties of alkali Rydberg atoms

    NASA Astrophysics Data System (ADS)

    Šibalić, N.; Pritchard, J. D.; Adams, C. S.; Weatherill, K. J.

    2017-11-01

    We present an object-oriented Python library for the computation of properties of highly-excited Rydberg states of alkali atoms. These include single-body effects such as dipole matrix elements, excited-state lifetimes (radiative and black-body limited) and Stark maps of atoms in external electric fields, as well as two-atom interaction potentials accounting for dipole and quadrupole coupling effects valid at both long and short range for arbitrary placement of the atomic dipoles. The package is cross-referenced to precise measurements of atomic energy levels and features extensive documentation to facilitate rapid upgrade or expansion by users. This library has direct application in the field of quantum information and quantum optics which exploit the strong Rydberg dipolar interactions for two-qubit gates, robust atom-light interfaces and simulating quantum many-body physics, as well as the field of metrology using Rydberg atoms as precise microwave electrometers. Program Files doi:http://dx.doi.org/10.17632/hm5n8w628c.1 Licensing provisions: BSD-3-Clause Programming language: Python 2.7 or 3.5, with C extension External Routines: NumPy [1], SciPy [1], Matplotlib [2] Nature of problem: Calculating atomic properties of alkali atoms including lifetimes, energies, Stark shifts and dipole-dipole interaction strengths using matrix elements evaluated from radial wavefunctions. Solution method: Numerical integration of radial Schrödinger equation to obtain atomic wavefunctions, which are then used to evaluate dipole matrix elements. Properties are calculated using second order perturbation theory or exact diagonalisation of the interaction Hamiltonian, yielding results valid even at large external fields or small interatomic separation. Restrictions: External electric field fixed to be parallel to quantisation axis. Supplementary material: Detailed documentation (.html), and Jupyter notebook with examples and benchmarking runs (.html and .ipynb). [1] T.E. Oliphant, Comput. Sci. Eng. 9, 10 (2007). http://www.scipy.org/. [2] J.D. Hunter, Comput. Sci. Eng. 9, 90 (2007). http://matplotlib.org/.

  19. Analysis of a diffuse interface model of multispecies tumor growth

    NASA Astrophysics Data System (ADS)

    Dai, Mimi; Feireisl, Eduard; Rocca, Elisabetta; Schimperna, Giulio; Schonbek, Maria E.

    2017-04-01

    We consider a diffuse interface model for tumor growth recently proposed in Chen et al (2014 Int. J. Numer. Methods Biomed. Eng. 30 726-54). In this new approach sharp interfaces are replaced by narrow transition layers arising due to adhesive forces among the cell species. Hence, a continuum thermodynamically consistent model is introduced. The resulting PDE system couples four different types of equations: a Cahn-Hilliard type equation for the tumor cells (which include proliferating and dead cells), a Darcy law for the tissue velocity field, whose divergence may be different from 0 and depend on the other variables, a transport equation for the proliferating (viable) tumor cells, and a quasi-static reaction diffusion equation for the nutrient concentration. We establish existence of weak solutions for the PDE system coupled with suitable initial and boundary conditions. In particular, the proliferation function at the boundary is supposed to be nonnegative on the set where the velocity \\mathbf{u} satisfies \\mathbf{u}\\centerdot ν >0 , where ν is the outer normal to the boundary of the domain.

  20. Using IMPRINT to Guide Experimental Design with Simulated Task Environments

    DTIC Science & Technology

    2015-06-18

    USING IMPRINT TO GUIDE EXPERIMENTAL DESIGN OF SIMULATED TASK ENVIRONMENTS THESIS Gregory...ENG-MS-15-J-052 USING IMPRINT TO GUIDE EXPERIMENTAL DESIGN WITH SIMULATED TASK ENVIRONMENTS THESIS Presented to the Faculty Department...Civilian, USAF June 2015 DISTRIBUTION STATEMENT A. APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. AFIT-ENG-MS-15-J-052 USING IMPRINT

  1. 78 FR 40266 - Agency Information Collection Activity Under OMB Review; Reports, Forms and Recordkeeping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ...- 70-ENG2, KP2-71-ENG3. Abstract: 46 U.S.C. 51309 authorizes the Academy to confer academic degrees. To maintain the appropriate academic standards, the program must be accredited by the appropriate accreditation body. The survey is part of USMMA's academic accreditation process. Annual Estimated Burden Hours...

  2. An Analysis of Curriculum Renewal in EAP Context

    ERIC Educational Resources Information Center

    Yurekli, Aynur

    2012-01-01

    This study aims at describing the new approach to English for Academic Purposes (EAP) teaching based on the results of the curriculum renewal conducted for the freshman "Academic Skills in English" courses (ENG 101 and ENG 102) with reference to the Faculty of Computer Sciences. The study is based on the results of the needs analysis…

  3. A Survey of Electronic News Gathering and Television News Coverage.

    ERIC Educational Resources Information Center

    Stone, Vernon A.; DiCioccio, John P.

    A 1977 national survey of 216 television stations that use electronic news gathering (ENG) and of 224 stations that still use only film for camera reporting showed little difference in the types of news the two kinds of operations covered, although stations using ENG shot more stories than did those still using only film. The persons making…

  4. A Study of Dim Object Detection for the Space Surveillance Telescope

    DTIC Science & Technology

    2013-03-21

    ENG-13-M-32 Abstract Current methods of dim object detection for space surveillance make use of a Gaussian log-likelihood-ratio-test-based...quantitatively comparing the efficacy of two methods for dim object detection , termed in this paper the point detector and the correlator, both of which rely... applications . It is used in national defense for detecting satellites. It is used to detecting space debris, which threatens both civilian and

  5. Planning of a Demonstration Project for Main Channel Disposal of Dredged Material.

    DTIC Science & Technology

    1980-07-01

    S imon Eng lieerlng Reserch Center Y.. C Colorado State University Fort C.Ilin, Colredo- 0 -d - *-¢ i ,.., . . . FOREWORD This study was...program which identifies data needs, equipment needs and methods for collection and analyses of samples , sampling frequencies and spacing and cost...4.3.1 Data Needs .. ........ ....... 65 4.3.2 Equipment Needs and Methods for Collection and Analyses of Samples . 5 4.3.3 Sampling Frequencies and

  6. Dynamic Modeling of Cell-Free Biochemical Networks Using Effective Kinetic Models

    DTIC Science & Technology

    2015-03-16

    sensitivity value was the maximum uncertainty in that value estimated by the Sobol method. 2.4. Global Sensitivity Analysis of the Reduced Order Coagulation...sensitivity analysis, using the variance-based method of Sobol , to estimate which parameters controlled the performance of the reduced order model [69]. We...Environment. Comput. Sci. Eng. 2007, 9, 90–95. 69. Sobol , I. Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates

  7. Dynamic Modeling of the Human Coagulation Cascade Using Reduced Order Effective Kinetic Models (Open Access)

    DTIC Science & Technology

    2015-03-16

    shaded region around each total sensitivity value was the maximum uncertainty in that value estimated by the Sobol method. 2.4. Global Sensitivity...Performance We conducted a global sensitivity analysis, using the variance-based method of Sobol , to estimate which parameters controlled the...Hunter, J.D. Matplotlib: A 2D Graphics Environment. Comput. Sci. Eng. 2007, 9, 90–95. 69. Sobol , I. Global sensitivity indices for nonlinear

  8. Overview of the Enhanced Natural Gestures Instructional Approach and Illustration of Its Use with Three Students with Angelman Syndrome

    ERIC Educational Resources Information Center

    Calculator, Stephen; Diaz-Caneja Sela, Patricia

    2015-01-01

    Background: This investigation details procedures used to teach enhanced natural gestures (ENGs) and illustrates its use with three students with Angelman syndrome (AS). Materials and Methods: Themes were extracted, using a process of content analysis, to organize individuals' feedback pertaining to previous versions of the instructional…

  9. [The segregation of young adult migrants in Indonesia].

    PubMed

    Bandiyono, S

    1985-06-01

    "The purpose of this paper is to [describe] the segregation of young adult migrants in Indonesia using the index of dissimilarity method. The paper argues that the existence of urban bias has created migration to urban areas." The author suggests that urban areas attract young people with more education and better occupational qualifications and skills. (summary in ENG) excerpt

  10. Manufacturing Methods and Technology Measure for Fabrication of Silicon Transcalent Rectifier.

    DTIC Science & Technology

    1980-09-01

    Prod Test/Eval’, z HA Kotler a Patent- Power & E 1 RM Roderick Env. Eng. & Test 1 JB Grosh Iron Mouptain - .l TUBE PARTS MFG. 5 RL SPALDING...AFAL/PODI ATTN: Working Group on Pwr. Devices (Mr. Philip Herron) 201 Varick Street Wright Patterson AFB, OH 45433 New York, NY 10014 Commander Mr

  11. Evaluation of biochemical markers combined with uterine artery Doppler parameters in fetuses with growth restriction: a case-control study.

    PubMed

    Zamarian, Ana Cristina Perez; Araujo Júnior, Edward; Daher, Sílvia; Rolo, Liliam Cristine; Moron, Antonio Fernandes; Nardozza, Luciano Marcondes Machado

    2016-10-01

    Assessing the biochemical markers levels and the uterine artery Doppler (UtA) parameters in fetuses with growth restriction (FGR). Prospective case-control study included 66 patients with diagnosis of FGR and 64 healthy pregnancies at 24-41 weeks of gestation. For both groups, maternal circulating concentrations of biochemical factors of soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin(sEng), adiponectin, A disintegrin and metalloproteinases (ADAM-12), pregnancy-associated plasma protein-A (PAPP-A), angiopoietin-2 (ANGI-2), vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) were assayed by ELISA and UtA by Doppler were performed. ANOVA, Mann-Whitney tests and Pearson correlation coefficient were applied to compare the biochemical factors, UtA Doppler and EFW Z-score between the groups. Concentrations of sFlt-1, sEng, PAPP-A were significantly higher in FGR than controls (p < 0.0001, p = 0.02 and p = 0.03, respectively), but concentration of ANGI-2 (p < 0.0001) was significantly lower in FGR than controls and ADAM-12 levels had a tendency to be lower in the FGR, though not statistically significant (p = 0.059). Increased sEng concentrations were correlated with abnormal UtA Doppler in FGR. Fetal growth restriction fetuses showed increased serum levels of sFlt-1, sEng and PAPP-A with levels of ANGI-2 decreased and a positive association between elevated concentrations of sEng and changing impedance of UtA Doppler were observed.

  12. Reimagining "English 1311: Expository English Composition" as "Introduction to Rhetoric and Writing Studies"

    ERIC Educational Resources Information Center

    Ruecker, Todd

    2011-01-01

    English 1311: Expository English Composition is the first semester course in a two-semester first-year composition (FYC) sequence. Both ENG 1311 and its second-semester counterpart, ENG 1312, are required for all students unless they have transfer credit covering this requirement or place out of one or both of the courses via the College-Level…

  13. 4. "ARCHITECTURAL, FLOOR PLANELEVATIONSSECTIONS, OBSERVATION BUNKERS." Specifications No. ENG (NASA)04353631; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. "ARCHITECTURAL, FLOOR PLAN-ELEVATIONS-SECTIONS, OBSERVATION BUNKERS." Specifications No. ENG (NASA)04-353-63-1; Drawing No. 60-09-34; sheet 325. Ref. No. A-13. D.O. SERIES 1597/87. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunker 1-D-3, Test Area 1-125, northwest end of Altair Boulevard, Boron, Kern County, CA

  14. Solidification of a binary alloy: Finite-element, single-domain simulation and new benchmark solutions

    NASA Astrophysics Data System (ADS)

    Le Bars, Michael; Worster, M. Grae

    2006-07-01

    A finite-element simulation of binary alloy solidification based on a single-domain formulation is presented and tested. Resolution of phase change is first checked by comparison with the analytical results of Worster [M.G. Worster, Solidification of an alloy from a cooled boundary, J. Fluid Mech. 167 (1986) 481-501] for purely diffusive solidification. Fluid dynamical processes without phase change are then tested by comparison with previous numerical studies of thermal convection in a pure fluid [G. de Vahl Davis, Natural convection of air in a square cavity: a bench mark numerical solution, Int. J. Numer. Meth. Fluids 3 (1983) 249-264; D.A. Mayne, A.S. Usmani, M. Crapper, h-adaptive finite element solution of high Rayleigh number thermally driven cavity problem, Int. J. Numer. Meth. Heat Fluid Flow 10 (2000) 598-615; D.C. Wan, B.S.V. Patnaik, G.W. Wei, A new benchmark quality solution for the buoyancy driven cavity by discrete singular convolution, Numer. Heat Transf. 40 (2001) 199-228], in a porous medium with a constant porosity [G. Lauriat, V. Prasad, Non-darcian effects on natural convection in a vertical porous enclosure, Int. J. Heat Mass Transf. 32 (1989) 2135-2148; P. Nithiarasu, K.N. Seetharamu, T. Sundararajan, Natural convective heat transfer in an enclosure filled with fluid saturated variable porosity medium, Int. J. Heat Mass Transf. 40 (1997) 3955-3967] and in a mixed liquid-porous medium with a spatially variable porosity [P. Nithiarasu, K.N. Seetharamu, T. Sundararajan, Natural convective heat transfer in an enclosure filled with fluid saturated variable porosity medium, Int. J. Heat Mass Transf. 40 (1997) 3955-3967; N. Zabaras, D. Samanta, A stabilized volume-averaging finite element method for flow in porous media and binary alloy solidification processes, Int. J. Numer. Meth. Eng. 60 (2004) 1103-1138]. Finally, new benchmark solutions for simultaneous flow through both fluid and porous domains and for convective solidification processes are presented, based on the similarity solutions in corner-flow geometries recently obtained by Le Bars and Worster [M. Le Bars, M.G. Worster, Interfacial conditions between a pure fluid and a porous medium: implications for binary alloy solidification, J. Fluid Mech. (in press)]. Good agreement is found for all tests, hence validating our physical and numerical methods. More generally, the computations presented here could now be considered as standard and reliable analytical benchmarks for numerical simulations, specifically and independently testing the different processes underlying binary alloy solidification.

  15. The spikes from Richtmyer-Meshkov instabilities in pused power cylindrical experiments

    NASA Astrophysics Data System (ADS)

    Rousculp, Chris; Cheng, Baolian; Oro, David; Griego, Jeffrey; Patten, Austin; Neukirch, Levi; Reinovsky, Robert; Turchi, Peter; Bradley, Joeph; Reass, Wlliam; Fierro, Franklin; Saunders, Alexsander; Mariam, Fesseha; Freeman, Matthew; Tang, Zhaowen

    2017-06-01

    The time evolution of the metal spikes resulting from the Richtmyer-Meshkov instability (RMI) of single-mode perturbations on the inside surface of a tin sample in cylindrical geometry has been measured for the first time. The shock condition was produced by a magnetically driven aluminum flyer utilizing the PHELIX capacitor bank. By varying the flyer velocity, a set of experiments conducted at the Los Alamos National Laboratory has explored the RMI evolution in the different release states (fluid, mixed, solid) of tin. The perturbation inversion and growth rate of the spikes were diagnosed in each experiment with a 21-image proton radiography (pRad) movie. Both theoretical model and numerical simulations are performed. Numerical simulations, theory and experimental data are in good agreement. Detailed analysis of the spike growth rates, comparison to planer geometry, as well as theory and computations will be presented. This work was conducted under the auspices of the U.S. Department of Energy by the Los Alamos National Laboratory under Contract No. W-7405-ENG-36.

  16. Recording of electroneurograms from the nerves innervating the pancreas of a dog.

    PubMed

    Rozman, J; Zorko, B; Bunc, M

    2001-12-15

    Electroneurograms (ENGs) from the vagus, splanchnic and pancreatic nerves innervating the pancreas of a dog, were recorded with chronically implanted silicone multi-electrode circular cuffs in an intact pancreas and in a pancreas partly disabled with alloxan. The cuffs contained 33 platinum electrodes (0.6x1.5 mm) arranged in three parallel circular groups integrated into the inner surface of the cuff. Each circular group contained 11 electrodes at a distance of 0.5 mm apart, with 6 mm between the circular groups. The cuffs had an inner diameter of 2.5 mm and the length of 18 mm. In a 2-year study, the cuffs were implanted into two adult Beagle dogs (one female and one male). In the vagus nerve, the cuff was installed on the nerve at the neck, whilst in the splanchnic nerve, the cuff was installed on the nerve before the celiac ganglion, and in the pancreatic nerve, the cuff was installed on the nerve just before it enters the pancreas. In each of the three implanted cuffs, the electrodes of the central circular group were connected to each other and this signal provided one input to a multi-channel ENG amplifying system. The electrodes of each of the two outer spiral groups were connected to each other and then both these groups were short-circuited. This signal then provided another input to the multi-channel ENG amplifying system. The ENG amplifying system was designed to amplify the ENGs 100000 times and to pass frequencies of between 500 and 10 kHz. In our study, three recordings in each animal were conducted. Recordings in the intact pancreas were conducted 2 and 6 months after the implantation, while the recording in the partly disabled pancreas, was conducted 10 months after the implantation and 10 days after the disablement. Due to the fact that the results obtained in both animals were actually quite similar, we present the results of the recordings obtained in one animal. In both animals the cuffs were left implanted for more than 1 year and were used for pancreatic stimulation, although this is not in this paper. The results show that cuffs implanted chronically on the nerves innervating the pancreas of a dog could reliably record the ENGs. This information could be used effectively in further study of pancreatic innervation and its function. Moreover, the results suggest that cuffs could also be useful in recording the ENGs from other nerves of the autonomic nervous system that innervate various glands and internal organs.

  17. Progress in development of HEDP capabilities in FLASH's Unsplit Staggered Mesh MHD solver

    NASA Astrophysics Data System (ADS)

    Lee, D.; Xia, G.; Daley, C.; Dubey, A.; Gopal, S.; Graziani, C.; Lamb, D.; Weide, K.

    2011-11-01

    FLASH is a publicly available astrophysical community code designed to solve highly compressible multi-physics reactive flows. We are adding capabilities to FLASH that will make it an open science code for the academic HEDP community. Among many important numerical requirements, we consider the following features to be important components necessary to meet our goals for FLASH as an HEDP open toolset. First, we are developing computationally efficient time-stepping integration methods that overcome the stiffness that arises in the equations describing a physical problem when there are disparate time scales. To this end, we are adding two different time-stepping schemes to FLASH that relax the time step limit when diffusive effects are present: an explicit super-time-stepping algorithm (Alexiades et al. in Com. Num. Mech. Eng. 12:31-42, 1996) and a Jacobian-Free Newton-Krylov implicit formulation. These two methods will be integrated into a robust, efficient, and high-order accurate Unsplit Staggered Mesh MHD (USM) solver (Lee and Deane in J. Comput. Phys. 227, 2009). Second, we have implemented an anisotropic Spitzer-Braginskii conductivity model to treat thermal heat conduction along magnetic field lines. Finally, we are implementing the Biermann Battery term to account for spontaneous generation of magnetic fields in the presence of non-parallel temperature and density gradients.

  18. Fractional Step Like Schemes for Free Surface Problems with Thermal Coupling Using the Lagrangian PFEM

    NASA Astrophysics Data System (ADS)

    Aubry, R.; Oñate, E.; Idelsohn, S. R.

    2006-09-01

    The method presented in Aubry et al. (Comput Struc 83:1459-1475, 2005) for the solution of an incompressible viscous fluid flow with heat transfer using a fully Lagrangian description of motion is extended to three dimensions (3D) with particular emphasis on mass conservation. A modified fractional step (FS) based on the pressure Schur complement (Turek 1999), and related to the class of algebraic splittings Quarteroni et al. (Comput Methods Appl Mech Eng 188:505-526, 2000), is used and a new advantage of the splittings of the equations compared with the classical FS is highlighted for free surface problems. The temperature is semi-coupled with the displacement, which is the main variable in a Lagrangian description. Comparisons for various mesh Reynolds numbers are performed with the classical FS, an algebraic splitting and a monolithic solution, in order to illustrate the behaviour of the Uzawa operator and the mass conservation. As the classical fractional step is equivalent to one iteration of the Uzawa algorithm performed with a standard Laplacian as a preconditioner, it will behave well only in a Reynold mesh number domain where the preconditioner is efficient. Numerical results are provided to assess the superiority of the modified algebraic splitting to the classical FS.

  19. The Development of Morphological Awareness in Young Bilinguals: Effects of Age and L1 Background

    ERIC Educational Resources Information Center

    Lam, Boji Pak-Wing; Sheng, Li

    2016-01-01

    Purpose: Current understanding about the effect of first language (L1) background on morphological awareness (MA) development in those who are bilingual is largely limited to school-aged second-language learners. This study examined the development of MA in bilingual Mandarin-English (ManEngBi) and Spanish-English (SpaEngBi) children ages 4 to 7…

  20. Instrumentation and control building, architectural, floor plans. Specifications no. Eng043535572; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Instrumentation and control building, architectural, floor plans. Specifications no. Eng-04-353-55-72; Drawing No. 60-09-12' sheet 64 of 148; file no. 1321/15. Stamped: record drawing - as constructed. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Control Center, Test Area 1-115, near Altair & Saturn Boulevards, Boron, Kern County, CA

  1. 26. "TEST STAND, STRUCTURAL, FOUNDATION PLAN." Specifications No. ENG043535572; Drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. "TEST STAND, STRUCTURAL, FOUNDATION PLAN." Specifications No. ENG-04-353-55-72; Drawing No. 60-0912; sheet 25 of 148; file no. 1320/76. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

  2. Bibliography on Cold Regions Science and Technology. Volume 41. Part 2

    DTIC Science & Technology

    1987-12-01

    Aletschgletscher [1984, p.9-25, eng, 41-622 Aleksandrov, B.M. Multivariate regression analysis of the process of frozen peat dehydration [1986. p.15-19...freezing of high- way bridge decks [1977. 5p., eng] 41-4604 Britton, K.B. Low temperature effects on sorption. hydrolysis ...snowy season in 1986 at Sapporo [1986. p.17-23. jpn) 41-3503 Ishikawa, S. Experimental decomposition of

  3. Development, Parameterization, and Validation of a Visco-Plastic Material Model for Sand with DifferentLevels of Water Saturation

    DTIC Science & Technology

    2009-01-01

    Generali- zed cap model for geological materials. J. Geotech . Eng. Div. ASME, 1976, 102(GT7), 638–699. 25 Sandler, I. S. and Rubin, D. An algorithm and a...under high strain rate loading. J. Geotech . Geoenviron. Eng., 2007, 133(2), 206–214. 27 Wong, J. R. and Reece, A. R. Prediction of rigid wheel

  4. Improving the Quality of Service and Security of Military Networks with a Network Tasking Order Process

    DTIC Science & Technology

    2010-09-01

    IMPROVING THE QUALITY OF SERVICE AND SECURITY OF MILITARY NETWORKS WITH A NETWORK TASKING ORDER...United States. AFIT/DCS/ENG/10-09 IMPROVING THE QUALITY OF SERVICE AND SECURITY OF MILITARY NETWORKS WITH A NETWORK TASKING ORDER PROCESS...USAF September 2010 APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED AFIT/DCS/ENG/10-09 IMPROVING THE QUALITY OF SERVICE AND

  5. YouTube War: Fighting in a World of Cameras in Every Cell Phone and Photoshop on Every Computer

    DTIC Science & Technology

    2009-11-01

    free MovieMaker 2 program that Microsoft includes with its Windows XP operating system. Mike Wendland, “From ENG to SNG : TV Technology for Covering the...the deployed soldier. 51. Wendland, “From ENG to SNG .” 52. This is based in part on the typology in Ben Venzke, “Jihadi Master Video Guide, JMVG

  6. Novel multipurpose pod-intravaginal ring for the prevention of HIV, HSV, and unintended pregnancy: Pharmacokinetic evaluation in a macaque model.

    PubMed

    Smith, James M; Moss, John A; Srinivasan, Priya; Butkyavichene, Irina; Gunawardana, Manjula; Fanter, Rob; Miller, Christine S; Sanchez, Debbie; Yang, Flora; Ellis, Shanon; Zhang, Jining; Marzinke, Mark A; Hendrix, Craig W; Kapoor, Amita; Baum, Marc M

    2017-01-01

    Globally, women bear an uneven burden for sexual HIV acquisition. Results from two clinical trials evaluating intravaginal rings (IVRs) delivering the antiretroviral agent dapivirine have shown that protection from HIV infection can be achieved with this modality, but high adherence is essential. Multipurpose prevention technologies (MPTs) can potentially increase product adherence by offering protection against multiple vaginally transmitted infections and unintended pregnancy. Here we describe a coitally independent, long-acting pod-IVR MPT that could potentially prevent HIV and HSV infection as well as unintended pregnancy. The pharmacokinetics of MPT pod-IVRs delivering tenofovir alafenamide hemifumarate (TAF2) to prevent HIV, acyclovir (ACV) to prevent HSV, and etonogestrel (ENG) in combination with ethinyl estradiol (EE), FDA-approved hormonal contraceptives, were evaluated in pigtailed macaques (N = 6) over 35 days. Pod IVRs were exchanged at 14 days with the only modification being lower ENG release rates in the second IVR. Plasma progesterone was monitored weekly to determine the effect of ENG/EE on menstrual cycle. The mean in vivo release rates (mg d-1) for the two formulations over 30 days ranged as follows: TAF2 0.35-0.40; ACV 0.56-0.70; EE 0.03-0.08; ENG (high releasing) 0.63; and ENG (low releasing) 0.05. Mean peak progesterone levels were 4.4 ± 1.8 ng mL-1 prior to IVR insertion and 0.075 ± 0.064 ng mL-1 for 5 weeks after insertion, suggesting that systemic EE/ENG levels were sufficient to suppress menstruation. The TAF2 and ACV release rates and resulting vaginal tissue drug concentrations (medians: TFV, 2.4 ng mg-1; ACV, 0.2 ng mg-1) may be sufficient to protect against HIV and HSV infection, respectively. This proof of principle study demonstrates that MPT-pod IVRs could serve as a potent biomedical prevention tool to protect women's sexual and reproductive health and may increase adherence to HIV PrEP even among younger high-risk populations.

  7. Comparison of analytical and numerical approaches for CT-based aberration correction in transcranial passive acoustic imaging

    NASA Astrophysics Data System (ADS)

    Jones, Ryan M.; Hynynen, Kullervo

    2016-01-01

    Computed tomography (CT)-based aberration corrections are employed in transcranial ultrasound both for therapy and imaging. In this study, analytical and numerical approaches for calculating aberration corrections based on CT data were compared, with a particular focus on their application to transcranial passive imaging. Two models were investigated: a three-dimensional full-wave numerical model (Connor and Hynynen 2004 IEEE Trans. Biomed. Eng. 51 1693-706) based on the Westervelt equation, and an analytical method (Clement and Hynynen 2002 Ultrasound Med. Biol. 28 617-24) similar to that currently employed by commercial brain therapy systems. Trans-skull time delay corrections calculated from each model were applied to data acquired by a sparse hemispherical (30 cm diameter) receiver array (128 piezoceramic discs: 2.5 mm diameter, 612 kHz center frequency) passively listening through ex vivo human skullcaps (n  =  4) to emissions from a narrow-band, fixed source emitter (1 mm diameter, 516 kHz center frequency). Measurements were taken at various locations within the cranial cavity by moving the source around the field using a three-axis positioning system. Images generated through passive beamforming using CT-based skull corrections were compared with those obtained through an invasive source-based approach, as well as images formed without skull corrections, using the main lobe volume, positional shift, peak sidelobe ratio, and image signal-to-noise ratio as metrics for image quality. For each CT-based model, corrections achieved by allowing for heterogeneous skull acoustical parameters in simulation outperformed the corresponding case where homogeneous parameters were assumed. Of the CT-based methods investigated, the full-wave model provided the best imaging results at the cost of computational complexity. These results highlight the importance of accurately modeling trans-skull propagation when calculating CT-based aberration corrections. Although presented in an imaging context, our results may also be applicable to the problem of transmit focusing through the skull.

  8. A mathematical analysis of the ABCD criteria for diagnosing malignant melanoma

    NASA Astrophysics Data System (ADS)

    Lee, Hyunju; Kwon, Kiwoon

    2017-03-01

    The medical community currently employs the ABCD (asymmetry, border irregularity, color variegation, and diameter of the lesion) criteria in the early diagnosis of a malignant melanoma. Although many image segmentation and classification methods are used to analyze the ABCD criteria, it is rare to see a study containing mathematical justification of the parameters that are used to quantify the ABCD criteria. In this paper, we suggest new parameters to assess asymmetry, border irregularity, and color variegation, and explain the mathematical meaning of the parameters. The suggested parameters are then tested with 24 skin samples. The parameters suggested for the 24 skin samples are displayed in three-dimensional coordinates and are compared to those presented in other studies (Ercal et al 1994 IEEE Trans. Biomed. Eng. 41 837-45, Cheerla and Frazier 2014 Int. J. Innovative Res. Sci., Eng. Technol. 3 9164-83) in terms of Pearson correlation coefficient and classification accuracy in determining the malignancy of the lesions.

  9. Keyphrase based Evaluation of Automatic Text Summarization

    NASA Astrophysics Data System (ADS)

    Elghannam, Fatma; El-Shishtawy, Tarek

    2015-05-01

    The development of methods to deal with the informative contents of the text units in the matching process is a major challenge in automatic summary evaluation systems that use fixed n-gram matching. The limitation causes inaccurate matching between units in a peer and reference summaries. The present study introduces a new Keyphrase based Summary Evaluator KpEval for evaluating automatic summaries. The KpEval relies on the keyphrases since they convey the most important concepts of a text. In the evaluation process, the keyphrases are used in their lemma form as the matching text unit. The system was applied to evaluate different summaries of Arabic multi-document data set presented at TAC2011. The results showed that the new evaluation technique correlates well with the known evaluation systems: Rouge1, Rouge2, RougeSU4, and AutoSummENG MeMoG. KpEval has the strongest correlation with AutoSummENG MeMoG, Pearson and spearman correlation coefficient measures are 0.8840, 0.9667 respectively.

  10. Stick-slip chaos in a mechanical oscillator with dry friction

    NASA Astrophysics Data System (ADS)

    Kousaka, Takuji; Asahara, Hiroyuki; Inaba, Naohiko

    2018-03-01

    This study analyzes a forced mechanical dynamical system with dry friction that can generate chaotic stick-slip vibrations. We find that the dynamics proposed by Yoshitake et al. [Trans. Jpn. Soc. Mech. Eng. C 61, 768 (1995)] can be expressed as a nonautonomous constraint differential equation owing to the static friction force. The object is constrained to the surface of a moving belt by a static friction force from when it sticks to the surface until the force on the object exceeds the maximal static friction force. We derive a 1D Poincaré return map from the constrained mechanical system, and prove numerically that this 1D map has an absolutely continuous invariant measure and a positive Lyapunov exponent, providing strong evidence for chaos.

  11. [Overpopulation--a cause of war? Notes on the population theory of Thomas Robert Malthus].

    PubMed

    Wenig, A

    1985-01-01

    The relationship between Malthusian pressures and the frequency of wars in seventeenth- and eighteenth-century Europe is examined. The author concludes that Europe at that time could easily support its population above subsistence level. "It was the political regime of absolutism which established mechanisms of income distribution that impoverished a large fraction of the society. The numerous barriers to market entry of the guild system and primogeniture as the predominant bequest rule among nobles left many young men, commoners and nobles alike, no choice but to join the army. In order to reduce the number of expensive mercenaries it was then individually rational for the princes to more or less continuously participate in militant conflicts." (summary in ENG, FRE) excerpt

  12. Soluble fms-Like Tyrosine Kinase 1 (sFlt1), Endoglin and Placental Growth Factor (PlGF) in Preeclampsia among High Risk Pregnancies

    PubMed Central

    Powers, Robert W.; Jeyabalan, Arun; Clifton, Rebecca G.; Van Dorsten, Peter; Hauth, John C.; Klebanoff, Mark A.; Lindheimer, Marshall D.; Sibai, Baha; Landon, Mark; Miodovnik, Menachem

    2010-01-01

    Background Differences in circulating concentrations of antiangiogenic factors sFlt1 and soluble endoglin (sEng) and the pro-angiogenic growth factor PlGF are reported to precede the onset of preeclampsia weeks to months in low-risk pregnant women. The objective of this study was to investigate whether similar changes can be detected in pregnant women at high-risk to develop the syndrome. Methods This study is a secondary analysis of the NICHD MFMU trial of aspirin to prevent preeclampsia in high-risk pregnancies. Serum samples were available from 194 women with pre-existing diabetes, 313 with chronic hypertension, 234 with multifetal gestation, and 252 with a history of preeclampsia in a previous pregnancy. Samples collected across pregnancy were analyzed in a blinded fashion for sFlt1, sEng and PlGF. Results The odds of developing preeclampsia were significantly increased among women with multiple fetuses for each 2-fold elevation in sFlt1, sEng and the ratio of angiogenic factors (e.g. OR 2.18, 95% CI 1.46-3.32), and significantly decreased for each 2-fold elevation in circulating PlGF (OR 0.50, 95% CI 0.30-0.82) between 7 and 26 weeks' gestation. Cross-sectional analysis of the angiogenic factors across gestation showed significant differences during the third trimester in women who develop preeclampsia compared with appropriate controls in all high-risk groups. However, when data were examined in relation to the gestational week when preeclampsia was diagnosed only sFlt1 was significantly higher 2 to 5 weeks before the clinical onset of preeclampsia and only in women with previous preeclampsia. Conclusions The pattern of elevated concentrations of sFlt1 and sEng, and low PlGF in high-risk pregnant subjects who develop preeclampsia is similar to that reported in low-risk pregnant women. However, differences in these factors among high-risk women who do and do not develop preeclampsia are modest, and do not appear to be clinically useful predictors in these high-risk pregnant women. PMID:20948996

  13. Improved colour matching technique for fused nighttime imagery with daytime colours

    NASA Astrophysics Data System (ADS)

    Hogervorst, Maarten A.; Toet, Alexander

    2016-10-01

    Previously, we presented a method for applying daytime colours to fused nighttime (e.g., intensified and LWIR) imagery (Toet and Hogervorst, Opt.Eng. 51(1), 2012). Our colour mapping not only imparts a natural daylight appearance to multiband nighttime images but also enhances the contrast and visibility of otherwise obscured details. As a result, this colourizing method leads to increased ease of interpretation, better discrimination and identification of materials, faster reaction times and ultimately improved situational awareness (Toet e.a., Opt.Eng.53(4), 2014). A crucial step in this colouring process is the choice of a suitable colour mapping scheme. When daytime colour images and multiband sensor images of the same scene are available the colour mapping can be derived from matching image samples (i.e., by relating colour values to sensor signal intensities). When no exact matching reference images are available the colour transformation can be derived from the first-order statistical properties of the reference image and the multiband sensor image (Toet, Info. Fus. 4(3), 2003). In the current study we investigated new colour fusion schemes that combine the advantages of the both methods, using the correspondence between multiband sensor values and daytime colours (1st method) in a smooth transformation (2nd method). We designed and evaluated three new fusion schemes that focus on: i) a closer match with the daytime luminances, ii) improved saliency of hot targets and iii) improved discriminability of materials

  14. The Impact of Army Transformation on the Integration of Enlisted Women

    DTIC Science & Technology

    2003-04-07

    Como & Info Ops 320 5421 5741 94% 6 CMF 31/Signal Ops 2783 20449 23232 88% CMF 37/Psych Ops 109 394 503 78% CMF 51/Gen Eng 293 5099 5392 95% CMF 54...31/Signal Ops 2499 20449 12% CMF 37/Psych Ops 36 394 9% CMF 51/Gen Eng 428 5099 8% CMF 54/Chemical 1237 4980 25% CMF 55/Ammunition 850 3322 26% CMF 81

  15. Actively Transmitting New DCPs - Hydrometeorological Automated Data System

    Science.gov Websites

    . 2016193 Map ALBERT 44409382 010000 AB ATHABASCA R. BEL. CASCADE RAPID 56.6203 -111.687 SIGNAL ENG. HG TA SIGNAL ENG. HG TA VB IM ID 2016104 Map ALBERT 4440F664 010000 AB ATHABASCA RIVER BELOW CROOKED R 56.5803 2016118 Map ALBERT 4441A4E2 010000 AB L. BOW R. BELOW TWIN VALLEY RES 50.2250 -113.397 HANDAR HG VB

  16. 10. "ARCHITECTURAL, SECTIONS AND DETAILS." Specifications No. ENG043535572; Drawing No. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. "ARCHITECTURAL, SECTIONS AND DETAILS." Specifications No. ENG-04-353-55-72; Drawing No. 60-09-12; sheet 23 of 148; file no. 1320/74. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

  17. Semantic Interpretation of An Artificial Neural Network

    DTIC Science & Technology

    1995-12-01

    ARTIFICIAL NEURAL NETWORK .7,’ THESIS Stanley Dale Kinderknecht Captain, USAF 770 DEAT7ET77,’H IR O C 7... ARTIFICIAL NEURAL NETWORK THESIS Stanley Dale Kinderknecht Captain, USAF AFIT/GCS/ENG/95D-07 Approved for public release; distribution unlimited The views...Government. AFIT/GCS/ENG/95D-07 SEMANTIC INTERPRETATION OF AN ARTIFICIAL NEURAL NETWORK THESIS Presented to the Faculty of the School of Engineering of

  18. Development of a Resource Manager Framework for Adaptive Beamformer Selection

    DTIC Science & Technology

    2013-12-27

    DEVELOPMENT OF A RESOURCE MANAGER FRAMEWORK FOR ADAPTIVE BEAMFORMER SELECTION DISSERTATION Jeremy P. Stringer, Major, USAF AFIT-ENG-DS-13-D-01...Force, the United States Department of Defense or the United States Government. AFIT-ENG-DS-13-D-01 DEVELOPMENT OF A RESOURCE MANAGER FRAMEWORK FOR...ADAPTIVE BEAMFORMER SELECTION DISSERTATION Presented to the Faculty Graduate School of Engineering and Management Air Force Institute of Technology Air

  19. Precision Relative Positioning for Automated Aerial Refueling from a Stereo Imaging System

    DTIC Science & Technology

    2015-03-01

    PRECISION RELATIVE POSITIONING FOR AUTOMATED AERIAL REFUELING FROM A STEREO IMAGING SYSTEM THESIS Kyle P. Werner, 2Lt, USAF AFIT-ENG-MS-15-M-048...REFUELING FROM A STEREO IMAGING SYSTEM THESIS Presented to the Faculty Department of Electrical and Computer Engineering Graduate School of...RELEASE; DISTRIBUTION UNLIMITED. AFIT-ENG-MS-15-M-048 PRECISION RELATIVE POSITIONING FOR AUTOMATED AERIAL REFUELING FROM A STEREO IMAGING SYSTEM THESIS

  20. Proceedings of the Symposium on Research in Biology and Biotechnology in Developing Countries (National University of Singapore, November 2-4, 1983). Selected Papers.

    ERIC Educational Resources Information Center

    Rao, A. N., Ed.

    These proceedings of a symposium designed to increase public awareness of current research in biology and biotechnology include: welcoming addresses by Chau Sian Eng and S. Radhakrishna; an opening address by Tay Eng Soon; five papers; four abstracts; summary; symposium program; and list of participants. The five papers are: (1) "The Role of…

  1. Angiogenic factors for prediction of preeclampsia and intrauterine growth restriction onset in high-risk women: AngioPred study.

    PubMed

    Raia-Barjat, Tiphaine; Prieux, Carole; Gris, Jean-Christophe; Chapelle, Céline; Laporte, Silvy; Chauleur, Céline

    2017-09-22

    The study aimed to compare the level of two angiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt1) and soluble endoglin (sEng), for the prediction of preeclampsia and intrauterine growth restriction in high-risk pregnant women. A prospective multicenter cohort study of 200 pregnant patients was conducted between June 2008 and October 2010. sFlt1 and sEng were measured by enzyme-linked immunosorbent assay. Forty-five patients developed a placenta-mediated adverse pregnancy outcome. Plasma levels of sFlt1 and sEng were higher in patients who will experience a preeclampsia at 28, 32, and 36 weeks compared with patients with no complication. The same results were observed for intrauterine growth restriction. Plasma levels of sFlt1 and sEng were not significantly different for patients with preeclampsia compare to patients with intrauterine growth restriction. Patients with early pre-eclampsia (PE) had very high rates of angiogenic factors at 20, 24, and 28 weeks. Patients with late PE and early and late intrauterine growth retardation (IUGR) had high rates at 32 and 36 weeks. In high-risk women, angiogenic factors are disturbed before the onset of preeclampsia and this is true for intrauterine growth restriction.

  2. Large Extremity Peripheral Nerve Repair

    DTIC Science & Technology

    2014-10-01

    nerve allotransplantation in rats immunosuppressed with transient or long-term FK-506. Journal of reconstructive microsurgery . 1996 Oct;12(7):451-9...outcomes in sensory, mixed, and motor nerve reconstructions . Microsurgery . 2012 Jan;32(1):1-14. PubMed PMID: 22121093. Epub 2011/11/29. eng. 12...method can provide fixation strengths 5 approaching that of conventional microsurgery and that the PTB repair is unlikely to be disturbed in vivo

  3. Air Force Institute of Technology Research Report 2008

    DTIC Science & Technology

    2009-05-01

    Chapter) Instructor of the Year, March 2008. PETERSON , GILBERT L. Air Force Junior Scientist of the Year, September 2008. RAINES, RICHARD A...DIRECTORATE RODRIGUEZ, BENJAMIN M., II, JPEG Steganography Embedding Methods. AFIT/DEE/ENG/08-20. Faculty Advisor: Dr. Gilbert L. Peterson . Sponsor...Faculty Advisor: Dr. Gilbert L. Peterson . Sponsor: AFRL/RY. GIRARD, JASON A., Material Perturbations to Enhance Performance of the Theile Half-Width

  4. A Three Dimensional Electronic Retina Architecture.

    DTIC Science & Technology

    1987-12-01

    not guarantee that a biological entity is in fact the best design because of the unique constraining factors of a biological organism and the associated...4. PERFORMING ORGANIZATION REPORT NUMBER(S) 5. MONITORING ORGANIZATION REPORT NUMBER(S) AFIT/GCS/ENG/87D-23 6a. NAME OF PERFORMING ORGANIZATION 6b...OFFICE SYMBOL 7a. NAME OF MONITORING ORGANIZATION (If applicable) School of Engineering AFIT/ENG 6c. ADDRESS (City, State, and ZIP Code) 7b. ADDRESS

  5. 7. "LAUNCH SILOS; SECTIONS, DETAILS." Specifications No. ENG043535973; Drawing No. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. "LAUNCH SILOS; SECTIONS, DETAILS." Specifications No. ENG-04-353-59-73; Drawing No. 5841-S-4; D.O. SERIES AW1525/26 Rev. A.; Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract No. 6601, Rev. A., Date 11 Sep 59. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Missile Silo Type, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

  6. Evaluation of Traditional Security Solutions in the SCADA Environment

    DTIC Science & Technology

    2012-03-01

    Evaluation of Traditional Security Solutions in the SCADA Environment THESIS Robert D. Larkin, Captain, USAF AFIT/GCO/ENG/12-06 DEPARTMENT OF THE AIR...views expressed in this thesis are those of the author and do not reflect the official policy or position of the United States Air Force, Department...United States. AFIT/GCO/ENG/12-06 Evaluation of Traditional Security Solutions in the SCADA Environment THESIS Presented to the Faculty Department of

  7. Actively Transmitting New DCPs - Hydrometeorological Automated Data System

    Science.gov Websites

    CT ASPETUCK RIVER NEAR ASPETUCK, C 411343 -0731926 SIGNAL ENG. HG VB 2013085 USGS01 DE2234D6 010000 CT BYRAM RIVER AT PEMBERWICK 410137 -0733940 SIGNAL ENG. HG PC VB 2013085 USGS01 17955470 010000 CT CT-CL 223 411832 -0723255 UNKNOWN HG WV WV VB HG WV WV HG EC EC EC EC EC EC 2016154 USGS01 DD3C65BA

  8. Air-to-Air Missile Enhanced Scoring with Kalman Smoothing

    DTIC Science & Technology

    2012-03-01

    Samuel and Robert Popoli. Modern Tracking Systems. Artech House, 1999. 3. Brown , Robert G. and Patrick Y. C. Hwang . Introduction to Random Signals and...Air-to-Air Missile Enhanced Scoring with Kalman Smoothing THESIS Jonathon Gipson, Captain, USAF AFIT/GE/ENG/12-18 DEPARTMENT OF THE AIR FORCE AIR...AFIT/GE/ENG/12-18 Air-to-Air Missile Enhanced Scoring with Kalman Smoothing THESIS Presented to the Faculty Department of Electrical and Computer

  9. PLC Hardware Discrimination using RF-DNA fingerprinting

    DTIC Science & Technology

    2014-06-19

    PLC HARDWARE DISCRIMINATION USING RF-DNA FINGERPRINTING THESIS Bradley C. Wright, Civilian, USAF AFIT-ENG-T-14-J-12 DEPARTMENT OF THE AIR FORCE AIR...protection in the United States. AFIT-ENG-T-14-J-12 PLC HARDWARE DISCRIMINATION USING RF-DNA FINGERPRINTING THESIS Presented to the Faculty Department...DISCRIMINATION USING RF-DNA FINGERPRINTING Bradley C. Wright, B.S.E.E. Civilian, USAF Approved: /signed/ Maj Samuel J. Stone, PhD (Chairman) /signed/ Michael A

  10. Angle of Arrival Detection Through Artificial Neural Network Analysis of Optical Fiber Intensity Patterns

    DTIC Science & Technology

    1990-12-01

    ARTIFICIAL NEURAL NETWORK ANALYSIS OF OPTICAL FIBER INTENSITY PATTERNS THESIS Scott Thomas Captain, USAF AFIT/GE/ENG/90D-62 DTIC...ELECTE ao • JAN08 1991 Approved for public release; distribution unlimited. AFIT/GE/ENG/90D-62 ANGLE OF ARRIVAL DETECTION THROUGH ARTIFICIAL NEURAL NETWORK ANALYSIS... ARTIFICIAL NEURAL NETWORK ANALYSIS OF OPTICAL FIBER INTENSITY PATTERNS L Introduction The optical sensors of United States Air Force reconnaissance

  11. 30. "CONSTRUCTION PHASING, STATION '50' AREA." Specifications No. ENG043535775, Drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. "CONSTRUCTION PHASING, STATION '50' AREA." Specifications No. ENG-04-353-57-75, Drawing No. AF-4502-19, sheet 4 of 5, D.O. Series No. AF 1439/26. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 5296, Date: 10 NOV. 59. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

  12. (YIP 2011) Unsteady Output-based Adaptive Simulation of Separated and Transitional Flows

    DTIC Science & Technology

    2015-03-19

    Investigator Aerospace Eng. U. Michigan Marco Ceze Ph.D. student/postdoctoral associate Aerospace Eng. U. Michigan Steven Kast Ph.D. student Aerospace...13] S. M. Kast , M. A. Ceze, and K. J. Fidkowski. Output-adaptive solution strategies for unsteady aerodynamics on deformable domains. Seventh...International Conference on Computational Fluid Dynamics ICCFD7-3802, 2012. [14] S. M. Kast and K. J. Fidkowski. Output-based mesh adaptation for high order

  13. Benchmarking on Tsunami Currents with ComMIT

    NASA Astrophysics Data System (ADS)

    Sharghi vand, N.; Kanoglu, U.

    2015-12-01

    There were no standards for the validation and verification of tsunami numerical models before 2004 Indian Ocean tsunami. Even, number of numerical models has been used for inundation mapping effort, evaluation of critical structures, etc. without validation and verification. After 2004, NOAA Center for Tsunami Research (NCTR) established standards for the validation and verification of tsunami numerical models (Synolakis et al. 2008 Pure Appl. Geophys. 165, 2197-2228), which will be used evaluation of critical structures such as nuclear power plants against tsunami attack. NCTR presented analytical, experimental and field benchmark problems aimed to estimate maximum runup and accepted widely by the community. Recently, benchmark problems were suggested by the US National Tsunami Hazard Mitigation Program Mapping & Modeling Benchmarking Workshop: Tsunami Currents on February 9-10, 2015 at Portland, Oregon, USA (http://nws.weather.gov/nthmp/index.html). These benchmark problems concentrated toward validation and verification of tsunami numerical models on tsunami currents. Three of the benchmark problems were: current measurement of the Japan 2011 tsunami in Hilo Harbor, Hawaii, USA and in Tauranga Harbor, New Zealand, and single long-period wave propagating onto a small-scale experimental model of the town of Seaside, Oregon, USA. These benchmark problems were implemented in the Community Modeling Interface for Tsunamis (ComMIT) (Titov et al. 2011 Pure Appl. Geophys. 168, 2121-2131), which is a user-friendly interface to the validated and verified Method of Splitting Tsunami (MOST) (Titov and Synolakis 1995 J. Waterw. Port Coastal Ocean Eng. 121, 308-316) model and is developed by NCTR. The modeling results are compared with the required benchmark data, providing good agreements and results are discussed. Acknowledgment: The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 603839 (Project ASTARTE - Assessment, Strategy and Risk Reduction for Tsunamis in Europe)

  14. The Department of the Navy Systems Engineering Career Competency Model

    DTIC Science & Technology

    2015-04-30

    competencies (Delgado, 2014). The SECCM has enhanced the current ENG model through the addition of extensive sets of KSAs mapped to each of the...SECCM then added KSA details from several other existing systems engineering competency models , many provided to the original NDIA SE WG, from a...to generate as complete a scope of SE KSA as possible. The ENG (formerly SPRDE) Career Field Competency Model was used as a basis for the set of

  15. Developing Cyberspace Data Understanding: Using CRISP-DM for Host-based IDS Feature Mining

    DTIC Science & Technology

    2010-03-01

    Developing Cyberspace Data Understanding: Using CRISP - DM for Host-based IDS Feature Mining THESIS Joseph R. Erskine, Captain, USAF AFIT/GCS/ENG/10-01...Air Force, Department of Defense, or the United States Government. AFIT/GCS/ENG/10-01 Developing Cyberspace Data Understanding: Using CRISP - DM for...Developing Cyberspace Data Understanding: Using CRISP - DM for Host-based IDS Feature Mining Joseph R. Erskine, B.S.C.S. Captain, USAF Approved: /signed/ 12

  16. Australian Disaster Research Directory (Including Some Contributions from New Zealand). Provisional--1983.

    DTIC Science & Technology

    1983-06-01

    storm surge, cyclone,fire) * social and physical effects of nuclear attack * volcanic hazards statistics of abnormal sea levels * management of high...strengths and weaknesses of these responses * Impact of environmental change on present and future disaster strategies SOME QUESTIONNAIRE STATISTICS Some of...James Cook Univ Black , Mr R G 99 Sen Lec, Civil Eng, QIT Blackman. Dr D R 86 Sen Lec, Dept Mech Eng, V---ash Blong, Dr Russell 80 Sen Lec, Earth

  17. Distributed Localization of Active Transmitters in a Wireless Sensor Network

    DTIC Science & Technology

    2012-03-01

    Distributed Localization of Active Transmitters in a Wireless Sensor Network THESIS Oba L. Vincent, 2nd Lieutenant, USAF AFIT/GE/ENG/12-41 DEPARTMENT...protection in the United States. AFIT/GE/ENG/12-41 Distributed Localization of Active Transmitters in a Wireless Sensor Network THESIS Presented to the...Transmitters in a Wireless Sensor Network Oba L. Vincent, B.S.E.E. 2nd Lieutenant, USAF Approved: /signed/ 29 Feb 2012 Maj. Mark D. Silvius, Ph.D. (Chairman

  18. Explicit Finite Element Method for Transparency Impact Analysis

    DTIC Science & Technology

    1991-06-01

    investigators have employed a similar concept for fiber-reinforced composite laminates (Chow 1971, 1975; Noor 1975, 1989; Chatterjee, 1979). Consider...Intense Impulsive Loads, It. J. Nuon. Meth. Engng. 14, 1865- 1871. Jones, R. M. (1975), Mechanics of Composite Materials, Scripta Book Co., Washington, D...Structural Dynamics, J. Eng. Mech. Div. 85, 67-94. Noor, A. K. (1975), Stability of Multilayered Composite Plates, Fibre Sci. Tech. 8, 81-89. Noor, A. K

  19. Vapor Intrusion Assessment and Mitigation 2012

    DTIC Science & Technology

    2012-03-26

    1 Geosyntec 0 consultants Vapor Intrusion Assessment and Mitigation 2012 Robert Ettinger, M.S., P.E., Todd McAiary, M.Sc., P.Eng., P.G...REPORT DATE 26 MAR 2012 2. REPORT TYPE 3. DATES COVERED 00-00-2012 to 00-00-2012 4. TITLE AND SUBTITLE Vapor Intrusion Assessment and...Updates • Typical Assessment Approaches and Common Challenges • Methods to Distinguish Background Sources (McHugh) • Significance • Compound

  20. Method and apparatus for secondary laser pumping by electron beam excitation

    DOEpatents

    George, E. Victor; Krupke, William F.; Murray, John R.; Powell, Howard T.; Swingle, James C.; Turner, Jr., Charles E.; Rhodes, Charles K.

    1978-01-01

    An electron beam of energy typically 100 keV excites a fluorescer gas which emits ultraviolet radiation. This radiation excites and drives an adjacent laser gas by optical pumping or photolytic dissociation to produce high efficiency pulses. The invention described herein was made in the course of, or under, United States Energy Research and Development Administration Contract No. W-7405-Eng-48 with the University of California.

  1. Catecholamine Enhancement and Visual Cortex Plasticity in Developing Kittens.

    DTIC Science & Technology

    1982-03-01

    ohm impedance tungsten-in-glass micro- electrode ( Levick , 1970). The output voltage changes were transmitted to an audio monitor through selectable...osmotic minipump. B . Illustration of injection method to fill iminpump and the assembled system. Figure 2 - Ocular dominance histograms of each...suppression with 6-hydroxydopamine. J. Neurophysiol. 45(2)t 254-266. Levick , W.R. (1972) Another tungsten microelectrode. Ked. and Fiol. Eng. 101 510-515

  2. [Automated processing of data from the 1985 population and housing census].

    PubMed

    Cholakov, S

    1987-01-01

    The author describes the method of automated data processing used in the 1985 census of Bulgaria. He notes that the computerization of the census involves decentralization and the use of regional computing centers as well as data processing at the Central Statistical Office's National Information Computer Center. Special attention is given to problems concerning the projection and programming of census data. (SUMMARY IN ENG AND RUS)

  3. Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis.

    PubMed

    Prystupa, Andrzej; Kiciński, Paweł; Luchowska-Kocot, Dorota; Błażewicz, Anna; Kurys-Denis, Ewa; Niedziałek, Jarosław; Sak, Jarosław; Panasiuk, Lech

    2017-09-21

    Liver cirrhosis is a disease involving the liver parenchyma, which is characterised by fibrosis and impaired architectonics of the parenchyma with regenerative nodules. The aim of the study was to determine the relationship between stage of alcoholic liver cirrhosis, concentrations of selenium, zinc and profibrotic and proangiogenic cytokines (FGF-19, ENG). The study included 99 patients with alcoholic cirrhosis and 20 healthy subjects. Ion chromatography with UV/VIS detection was used for determination of zinc ions in the previously mineralized serum samples. The measurements of selenium were performed with the ContrAA700 high-resolution continuum source graphite tube atomic absorption spectrometer. ELISA was used to determine concentration of FGF-19 and ENG in serum samples. Concentrations of zinc and selenium were significantly decreased in cirrhotic patients (p<0.001 for both). The highest concentration of FGF-19 was found in Child-Pugh stage C liver cirrhosis patients (806.9±650.3 pg/ml), and was significantly higher than observed in controls (p=0.005) and stage A patients (compensated cirrhosis) (p=0.02). The highest concentration of ENG was demonstrated in the control group (3.24±148 ng/ml) while the lowest in patients with decompensated cirrhosis (7.32±5.39 ng/ml and 7.92±4.18 ng/ml for stage B and C; p=0.03 and p=0.02, respectively). The use of the multiple-variable model demonstrated that the independent factors affecting the concentration of ENG were the concentration of bilirubin (p=0.02), INR (p=0.01) and duration of alcohol abuse (p=0.02). The independent determinants of FGF-19 concentrations were found to be the stage (severity) of liver cirrhosis (p=0.04) and INR (p=0.03). Concentrations of zinc and selenium in serum of patients with alcoholic liver cirrhosis are not independently related to concentrations of FGF-19 and ENG.

  4. Mammalian Cardiovascular Patterning as Determined by Hemodynamic Forces and Blood Vessel Genetics

    NASA Astrophysics Data System (ADS)

    Anderson, Gregory Arthur

    Cardiovascular development is a process that involves the timing of multiple molecular events, and numerous subtle three-dimensional conformational changes. Traditional developmental biology techniques have provided large quantities of information as to how these complex organ systems develop. However, the major drawback of the majority of current developmental biological imaging is that they are two-dimensional in nature. It is now well recognized that circulation of blood is required for normal patterning and remodeling of blood vessels. Normal blood vessel formation is dependent upon a complex network of signaling pathways, and genetic mutations in these pathways leads to impaired vascular development, heart failure, and lethality. As such, it is not surprising that mutant mice with aberrant cardiovascular patterning are so common, since normal development requires proper coordination between three systems: the heart, the blood, and the vasculature. This thesis describes the implementation of a three-dimensional imaging technique, optical projection tomography (OPT), in conjunction with a computer-based registration algorithm to statistically analyze developmental differences in groups of wild-type mouse embryos. Embryos that differ by only a few hours' gestational time are shown to have developmental differences in blood vessel formation and heart development progression that can be discerned. This thesis describes how we analyzed mouse models of cardiovascular perturbation by OPT to detect morphological differences in embryonic development in both qualitative and quantitative ways. Both a blood vessel specific mutation and a cardiac specific mutation were analyzed, providing evidence that developmental defects of these types can be quantified. Finally, we describe the implementation of OPT imaging to identify statistically significant phenotypes from three different mouse models of cardiovascular perturbation across a range of developmental time points. Image registration methods, combined with intensity- and deformation-based analyses are described and utilized to fully characterize myosin light chain 2a (Mlc2a), delta-like ligand 4 (Dll4), and Endoglin (Eng) mutant mouse embryos. We show that Eng mutant embryos are statistically similar to the Mlc2a phenotype, confirming that these mouse mutants suffer from a primary cardiac developmental defect. Thus, a loss of hemodynamic force caused by defective pumping of the heart is the primary developmental defect affecting these mice.

  5. Computing correct truncated excited state wavefunctions

    NASA Astrophysics Data System (ADS)

    Bacalis, N. C.; Xiong, Z.; Zang, J.; Karaoulanis, D.

    2016-12-01

    We demonstrate that, if a wave function's truncated expansion is small, then the standard excited states computational method, of optimizing one "root" of a secular equation, may lead to an incorrect wave function - despite the correct energy according to the theorem of Hylleraas, Undheim and McDonald - whereas our proposed method [J. Comput. Meth. Sci. Eng. 8, 277 (2008)] (independent of orthogonality to lower lying approximants) leads to correct reliable small truncated wave functions. The demonstration is done in He excited states, using truncated series expansions in Hylleraas coordinates, as well as standard configuration-interaction truncated expansions.

  6. Experimental and numerical analysis of penetration/removal response of endodontic instrument made of single crystal Cu-based SMA: comparison with NiTi SMA instruments

    NASA Astrophysics Data System (ADS)

    Vincent, M.; Xolin, P.; Gevrey, A.-M.; Thiebaud, F.; Engels-Deutsch, M.; Ben Zineb, T.

    2017-04-01

    This paper presents an experimental and numerical study showing that single crystal shape memory alloy (SMA) Cu-based endodontic instruments can lead to equivalent mechanical performances compared to NiTi-based instruments besides their interesting biological properties. Following a previous finite element analysis (FEA) of single crystal CuAlBe endodontic instruments (Vincent et al 2015 J. Mater. Eng. Perform. 24 4128-39), prototypes with the determined geometrical parameters were machined and experimentally characterized in continuous rotation during a penetration/removal (P/R) protocol in artificial canals. The obtained mechanical responses were compared to responses of NiTi endodontic files in the same conditions. In addition, FEA was conducted and compared with the experimental results to validate the adopted modeling and to evaluate the local quantities inside the instrument as the stress state and the distribution of volume fraction of martensite. The obtained results highlight that single crystal CuAlBe SMA prototypes show equivalent mechanical responses to its NiTi homologous prototypes in the same P/R experimental conditions.

  7. Sonobuoy-Based, 3-D Acoustic Characterization of Shallow-Water Environments

    DTIC Science & Technology

    2015-09-30

    10.1109/JOE.2014.2362838, ( IEEE Xplore Early Access, 4 Dec 2014)]. For each type of buoy, the eigenvalues at 50, 75, 125, and 175 Hz were used as input...using sonobuoys,” IEEE J. Ocean. Eng., vol. 40, no. 3, pp. 607-620, Jul. 2015 (DOI: 10.1109/JOE.2014.2362838, ( IEEE Xplore Early Access, 4 Dec 2014...et al, “Modal mapping experiment and geoacoustic inversion using sonobuoys,” IEEE J. Ocean. Eng., vol. 40, no. 3, pp. 607- 620, Jul. 2015 (DOI

  8. Bibliography on Cold Regions Science and Technology. Volume 47, Part 2, 1993

    DTIC Science & Technology

    1993-01-01

    characteristics of aluminum galvanic anodes 47-2608 Ai~oritlsm for remote sensing of vertical salt density distribu- in an arctic seawater (1993, p.261-27 7 . eng...trochemical characteristics of aluminum galvanic anodes 6 u 721 detector ( 19Ŗ. 9p.. eng1 47W95 in ’an arctic seawater (1993. p. 26 1 - 277 . engl...Electrochemical characteristics of aluminum galvanic See alo: Economic analysis cng 474999 anodes in an arctic seawater. Tamada. A.. et al. ( 1993

  9. CH-47F Improved Cargo Helicopter (CH-47F)

    DTIC Science & Technology

    2015-12-01

    Confidence Level Confidence Level of cost estimate for current APB: 50% The Confidence Level of the CH-47F APB cost estimate, which was approved on April...M) Initial PAUC Development Estimate Changes PAUC Production Estimate Econ Qty Sch Eng Est Oth Spt Total 10.316 -0.491 3.003 -0.164 2.273 7.378...SAR Baseline to Current SAR Baseline (TY $M) Initial APUC Development Estimate Changes APUC Production Estimate Econ Qty Sch Eng Est Oth Spt Total

  10. 2005 40th Annual Armament Systems: Guns - Ammunition - Rockets - Missiles Conference and Exhibition. Volume 3: Wednesday

    DTIC Science & Technology

    2005-04-28

    Lessons Learned, Mr. David F. Fair, US Army ARDEC Propellant Replacement for the 105-mm M67 Propelling Charge, Ms. Adriana L. Eng, US Army ARDEC Lead...Application of Lessons Learned Mr. David F. Fair, US Army ARDEC Propellant Replacement for the 105-mm Artillery Propelling Charge Ms. Adriana L. Eng...high voltage power supply (several kV and kA ) • Solid state Switching device • Appropriate dimensions en properties of: • Exploding foil • Flyer

  11. Bibliography on Cold Regions Science and Technology, Volume 46, Part 2, 1992

    DTIC Science & Technology

    1992-01-01

    Modelling of heat capacity-temperature data for sucrose- conditions: trial study . Peck, L.. 1)992. 15p.. eng) Comparison of four cold hardiness tests on...authors are listed along with the title, date, pagination, and language of the document and the accession number. The subject index is composed of four ...eng1 46-1074 Radar backscatter measurements during the Winter Weddell Abramov Glacier and the runoff in its basin (1989. p.85- Aakjaer. P.D. Gyre Study

  12. 15. "TEST STANDS NOS. 11, 13, & 15; STRUCTURAL STEEL; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. "TEST STANDS NOS. 1-1, 1-3, & 1-5; STRUCTURAL STEEL; PLAN & DETAILS." Specifications No. ENG 04-353-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/34, Rev. A. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. A, no change; Date: 21 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  13. 9. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. ENG 04-35350-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/13. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, no change; Date: 17 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  14. 16. "TEST STANDS NOS. 11, 13, & 15; STRUCTURAL STEEL; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. "TEST STANDS NOS. 1-1, 1-3, & 1-5; STRUCTURAL STEEL; ELEVATIONS AND SECTIONS." Specifications No. ENG 04353-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/35, Rev. A. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04-353 Eng. 177, Rev. A; Date: 29 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  15. Psychosocial work characteristics predicting daytime sleepiness in day and shift workers.

    PubMed

    Takahashi, Masaya; Nakata, Akinori; Haratani, Takashi; Otsuka, Yasumasa; Kaida, Kosuke; Fukasawa, Kenji

    2006-01-01

    Characteristics of work organization other than working time arrangements may contribute importantly to daytime sleepiness. The present study was designed to identify the psychosocial factors at work that predict daytime sleepiness in a sample of day and shift workers. Participants working at a pulp and chemical factory completed an annual questionnaire regarding psychosocial factors at work using the U.S. National Institute for Occupational Safety and Health Generic Job Stress Questionnaire (i.e., quantitative workload, variance in workload, job control, support from supervisor, coworkers, or family/friends, job satisfaction, and depressive symptoms), as well as daytime sleepiness (through the Epworth Sleepiness Scale [ESS]) and sleep disturbances for three years starting in 2002 (response rates, 94.6-99.0%). The present analysis included 55 day workers (11 women) and 57 shift workers (all men) who participated in all three years of the study, worked under the same work schedule throughout the study period, and had no missing data on any of the daytime sleep items. A repeated-measures analysis of covariance (ANCOVA) was used to test the effects of work schedule (day vs. shift work) and psychosocial factors at work in 2002 on the ESS scores in subsequent years, with sleep duration, insomnia symptoms, chronic diseases, and sleepiness levels at baseline as covariates. Given significant and near-significant interactions of work schedules with psychosocial factor or study year, the ANCOVA, with the factors of psychosocial work characteristics and study year, was performed by type of work schedule. The results indicated a significant main effect of psychosocial work characteristics (p = 0.010, partial eng2 = 0.14) and an almost significant main effect of study year (p = 0.067, partial eng2 = 0.06) and interaction between psychosocial work characteristics and study year (p = 0.085, partial eng2 = 0.06) for variance in workload among the day work group. The day workers reporting high variance in workload in 2002 exhibited significantly higher ESS scores in 2003 and 2004 than did those reporting low variance in workload. The ANCOVA for the shift work group showed a main effect of psychosocial work characteristics for job satisfaction (p = 0.026, partial eng2 = 0.10) and depressive symptoms (p = 0.094, partial eng2 = 0.06) with the interaction between psychosocial work characteristics and study year for job satisfaction (p = 0.172, partial eng2 = 0.04) and depressive symptoms (p = 0.035, partial eng2 = 0.07). The shift workers with low job satisfaction and high symptoms of depression in 2002 showed significantly greater ESS scores in 2003 and/or 2004 than did those with opposite characteristics. These results may suggest a potential predictive value of variance in workload for day workers as well as job satisfaction and depressive symptoms for shift workers with respect to daytime sleepiness. The present findings may imply that redesigning these aspects of work environment would be of help in managing daytime sleepiness.

  16. An analysis on the roles of angiogenesis-related factors including serum vitamin D, soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt1), and vascular endothelial growth factor (VEGF) in the diagnosis and severity of late-onset preeclampsia.

    PubMed

    Cim, Numan; Kurdoglu, Mertihan; Ege, Serhat; Yoruk, Ibrahim; Yaman, Gorkem; Yildizhan, Recep

    2017-07-01

    The aim of this study was to evaluate the roles of proangiogenic factors including serum vitamin D and vascular endothelial growth factor (VEGF) and anti-angiogenic factors including soluble endoglin (sEng) and soluble fms-like tyrosine kinase 1 (sFlt1) in the diagnosis and severity of late-onset preeclampsia. The study was conducted at Yuzuncu Yil University Research and Education Hospital Department of Gynecology and Obstetrics. The study included a patient group of 40 women with late-onset preeclampsia who were pregnant at ≥32 weeks of gestation according to the last menstrual period (LMP) or ultrasonographic fetal biometric measurement and a control group of 40 healthy pregnant women who presented to our clinic for routine pregnancy examination and were at the same age and gestational period with those in the patient group. The two groups were compared in terms of maternal age, gravida, parity, week of gestation, systolic/diastolic blood pressure, total protein in spot urine sample, 24-h urine protein, white blood cell (WBC), hemoglobin (Hgb), platelet count, urea, creatinine, liver function tests (AST, ALT, LDH), vitamin D 3 , 25(OH) vitamin D 3 , 1,25(OH) vitamin D 3 , sEng, sFlt1, and VEGF levels, mode of delivery, the infant APGAR score at 1 and 5 min after delivery, and infant weight at delivery. The groups were similar in terms of age, gravida, parity, week of gestation, serum vitamin D 3 , 25(OH) vitamin D 3 , 1,25(OH) 2 vitamin D 3 and VEGF levels, and infant weight at delivery (p > 0.05). Systolic/diastolic blood pressure, total protein in spot urine sample, 24-h urine protein, WBC, Hgb, serum urea, creatine, AST, ALT, and LDH were significantly higher in the preeclamptic group compared to the healthy group (p < 0.05). However, thrombocyte level and the APGAR score at 1 and 5 min after delivery were significantly lower in the preeclamptic group compared to the healthy group (p < 0.05). No significant correlation was found between serum sEng, sFlt1, VEGF, vitamin D 3 , 25(OH) vitamin D 3 , and 1,25(OH) 2 vitamin D 3 levels. The sEng level was higher in the women with severe preeclampsia compared to the women with mild preeclampsia (p < 0.05) and no significant difference was observed in serum sFlt1, VEGF, vitamin D 3 , 25(OH) vitamin D 3 , and 1,25(OH) 2 vitamin D 3 levels between the subgroups of preeclampsia (p > 0.05). Both sEng and sFlt1 levels are remarkably high in patients with late-onset preeclampsia; however, only sEng may be a useful tool in the determination of the severity of preeclampsia.

  17. An Experimental Study of Large Compressive Loads Upon Residual Strain Fields and the Interaction Between Surface Strain Fields Created by Coldworking Fastener Holes.

    DTIC Science & Technology

    1981-02-01

    Strains" (J. of Basic Eng., Vol. 82, Series D, June 1960), pp, 426-434. 10. Morse, S., A.J. Durelli, and C.A. Sciammarella , "Geo- metry of Moire...grid Method, a Practical Moire Stress-analysis Tool" (Exp. Mech., Vol. 7, July 1967), pp. 19A-22A. 20. Sciammarella , C., "Moire-fringe Multiplication

  18. One-year vestibular and balance outcomes of Oklahoma City bombing survivors.

    PubMed

    Van Campen, L E; Dennis, J M; King, S B; Hanlin, R C; Velderman, A M

    1999-10-01

    This multisite investigation assessed subjective, behavioral, and objective balance function in 30 blast survivors. Subjects with vertigo, dizziness, or imbalance were screened (n = 6) or evaluated (n = 27) during 1 year. Tests included a questionnaire, electronystagmography (ENG), and computerized dynamic posturography (CDP). Ninety-seven percent of subjects were located inside a building during the blast, and 63 percent of subjects experienced dysequilibrium within 48 hours. Forty-three percent of symptoms could not be attributed to head injury. Sixty percent of subjects had abnormal ENG and/or CDP; ENG abnormalities mostly were peripheral or nonlocalizing, whereas CDP patterns were "vestibular," "surface dependent," and "physiologically inconsistent." At 1-year postblast, 55 percent of initially abnormal CDP results were normal, and 72 percent of subjects said symptoms were unchanged or occurred intermittently. A serial, test battery approach is recommended to assess symptoms. Blast-related dysequilibrium had clinically significant manifestations and should be considered a valid component of aural blast injury.

  19. Evaluation of PET texture features with heterogeneous phantoms: complementarity and effect of motion and segmentation method

    NASA Astrophysics Data System (ADS)

    Carles, M.; Torres-Espallardo, I.; Alberich-Bayarri, A.; Olivas, C.; Bello, P.; Nestle, U.; Martí-Bonmatí, L.

    2017-01-01

    A major source of error in quantitative PET/CT scans of lung cancer tumors is respiratory motion. Regarding the variability of PET texture features (TF), the impact of respiratory motion has not been properly studied with experimental phantoms. The primary aim of this work was to evaluate the current use of PET texture analysis for heterogeneity characterization in lesions affected by respiratory motion. Twenty-eight heterogeneous lesions were simulated by a mixture of alginate and 18 F-fluoro-2-deoxy-D-glucose (FDG). Sixteen respiratory patterns were applied. Firstly, the TF response for different heterogeneous phantoms and its robustness with respect to the segmentation method were calculated. Secondly, the variability for TF derived from PET image with (gated, G-) and without (ungated, U-) motion compensation was analyzed. Finally, TF complementarity was assessed. In the comparison of TF derived from the ideal contour with respect to TF derived from 40%-threshold and adaptive-threshold PET contours, 7/8 TF showed strong linear correlation (LC) (p  <  0.001, r  >  0.75), despite a significant volume underestimation. Independence of lesion movement (LC in 100% of the combined pairs of movements, p  <  0.05) was obtained for 1/8 TF with U-image (width of the volume-activity histogram, WH) and 4/8 TF with G-image (WH and energy (ENG), local-homogeneity (LH) and entropy (ENT), derived from the co-ocurrence matrix). Their variability in terms of the coefficient of variance ({{C}\\text{V}} ) resulted in {{C}\\text{V}} (WH)  =  0.18 on the U-image and {{C}\\text{V}} (WH)  =  0.24, {{C}\\text{V}} (ENG)  =  0.15, {{C}\\text{V}} (LH)  =  0.07 and {{C}\\text{V}} (ENT)  =  0.06 on the G-image. Apart from WH (r  >  0.9, p  <  0.001), not one of these TF has shown LC with C max. Complementarity was observed for the TF pairs: ENG-LH, CONT (contrast)-ENT and LH-ENT. In conclusion, the effect of respiratory motion should be taken into account when the heterogeneity of lung cancer is quantified on PET/CT images. Despite inaccurate volume delineation, TF derived from 40% and COA contours could be reliable for their prognostic use. The TF that exhibited simultaneous added value and independence of lesion movement were ENG and ENT computed from the G-image. Their use is therefore recommended for heterogeneity quantification of lesions affected by respiratory motion.

  20. A Biographical Approach to Chinese Political Analysis

    DTIC Science & Technology

    1975-10-01

    Liu Po-ch’eng Chang Kuo -t ’ao Ch’en I Su Yll Lin Piao Nieh Jung -chen Sources: William Whitson, "The Field Army in Chinese Communist Military...since 1954 Founders 1, 2, 3, 5, 6 Ho Lung 12, 13, 14, 15, HeU Haiang-ch’ien 16, 18, 60 (in Liu Po-ch ’eng Szechwan), 61, 62 Chang Kuo -t’ ao 20...66, 67. 68 Nieh Jung -chen Sources: William Whitson, "The Field Army in Chinese Communist Military Politics," The China Quarterly, No, 37, Januar y

  1. Supporting Data for FY 1990/1991 Biennial Budget: Budget Estimates Descriptive Summaries Submitted to Congress January 1989, Research, Development, Test & Evaluation, Navy

    DTIC Science & Technology

    1989-01-01

    necessitate de -emphasizing network interface demonstrations in favor of real-time network interface technologies and slip ICEX demonstration of...Aperture Radar target classi- fication and Fault Diagnosis issues. o Demonstrate a complete, transportable , fully functional software engineering...BLK 3 MS 3B 109D MS 3A Blk 3 MS 2 TASM Milestones MS 3A 109D IOC Flex Upgrade MS 3B SW-3 MS 3B Blk 3 IOC Blk 3 Engineering Eng Dev Eng Dev DES Rev

  2. Development of High-Activity Para- to Ortho-Hydrogen Conversion Catalysts. Volume 2

    DTIC Science & Technology

    1989-09-28

    Proc. Roy. Soc. London AllO, 464 (1925). 2 1929 Para- and ortho-hydrogen, Barmois, E., La Nature No. 2820, 400-1 (1929) C.A. 24,, 1020b. K. F...U.S. At. Energy Comm. LA -2719, 40 pp. (1962); cf. 3. Chem. Eng. Data 7, 179(1962). C.A. 58, 10750g. Schmidt number for normal hydrogen and...A-L);- p 181-9; in Eng. Briones, A. G.; Garcia de la Banda, J. F.; Inst. Quim. Fis. Quim., Madrid, Anales Real. Soc. Espan. Fis. Quim. (Madrid); Ser

  3. A Computer Program for the Performance Analysis of Scarfed Nozzles

    DTIC Science & Technology

    1984-05-01

    University of Utah, Dept. of Mech. Eng. Attn: Prof. Gary A. Flandro 1 "..4. Merrill Eng. Bldg. or MEB 3008 Salt Lake City, UT 84112 Talley Industries...Copies ,.. - Hercules, Inc. - Attn: Gary D. Berg 1 P. O.1 Box 98 Magna, UT 84044 ’.’>" .. NASA, Lewis Research Center Attn: Mr. D. Bittker, MS 54-6-1...8217;’: _-• DISTRIBUTION LIST (CONT),I. No. Copies . ’ SEA, Incorporated Atti: Mr. Gary R. Nickerson 񓘸 Brookhollow Drive Santa Ana, CA 92705 p. , "Commander 00

  4. Analytic model for the long-term evolution of circular Earth satellite orbits including lunar node regression

    NASA Astrophysics Data System (ADS)

    Zhu, Ting-Lei; Zhao, Chang-Yin; Zhang, Ming-Jiang

    2017-04-01

    This paper aims to obtain an analytic approximation to the evolution of circular orbits governed by the Earth's J2 and the luni-solar gravitational perturbations. Assuming that the lunar orbital plane coincides with the ecliptic plane, Allan and Cook (Proc. R. Soc. A, Math. Phys. Eng. Sci. 280(1380):97, 1964) derived an analytic solution to the orbital plane evolution of circular orbits. Using their result as an intermediate solution, we establish an approximate analytic model with lunar orbital inclination and its node regression be taken into account. Finally, an approximate analytic expression is derived, which is accurate compared to the numerical results except for the resonant cases when the period of the reference orbit approximately equals the integer multiples (especially 1 or 2 times) of lunar node regression period.

  5. A Study on New Song of the Sky Pacers

    NASA Astrophysics Data System (ADS)

    Ahn, Sang-Hyeon

    2009-12-01

    We investigated `Song of the Sky Pacers, Adopted to the New Methods' (新法步天歌), the latest version of Joseon's `Song of the Sky Pacers' (步天歌). Due to the influence of new knowledge on Chinese asterisms imported from the Ching dynasty, `Song of the Sky Pacers with New Star-Charts' was written in the eighteenth century. However, the disagreement between song and star-charts was causing confusion in practical applications such as Joseon's national examination for selecting astronomers. In order to improve this situation, Royal Observatory of the Joseon dynasty (觀象監) published `Song of the Sky Pacers, Adopted to the New Methods' based upon star-charts and song in the Sequel of I-Hsiang-K'ao-ch'eng (欽定儀象考成續編). The New Song was edited by a middle-class professional astronomer Yi Jun-yang (李俊養), and corrected by a nobleman Nam Byeong-gil (南秉吉). We establish a brief biography of Yi Jun-yang. The New Song preserves the genuine characteristics of previous Joseon's Song including the format of title of each lunar mansion and description on the location of the Milky Way in the asterisms. The description of the Milky Way was newly written based on the data in volume 31 and 32 of the Sequel of I-Hsiang-K'ao-ch'eng.

  6. Comparison of Protein Immunoprecipitation-Multiple Reaction Monitoring with ELISA for Assay of Biomarker Candidates in Plasma

    PubMed Central

    2013-01-01

    Quantitative analysis of protein biomarkers in plasma is typically done by ELISA, but this method is limited by the availability of high-quality antibodies. An alternative approach is protein immunoprecipitation combined with multiple reaction monitoring mass spectrometry (IP-MRM). We compared IP-MRM to ELISA for the analysis of six colon cancer biomarker candidates (metalloproteinase inhibitor 1 (TIMP1), cartilage oligomeric matrix protein (COMP), thrombospondin-2 (THBS2), endoglin (ENG), mesothelin (MSLN) and matrix metalloproteinase-9 (MMP9)) in plasma from colon cancer patients and noncancer controls. Proteins were analyzed by multiplex immunoprecipitation from plasma with the ELISA capture antibodies, further purified by SDS-PAGE, digested and analyzed by stable isotope dilution MRM. IP-MRM provided linear responses (r = 0.978–0.995) between 10 and 640 ng/mL for the target proteins spiked into a “mock plasma” matrix consisting of 60 mg/mL bovine serum albumin. Measurement variation (coefficient of variation at the limit of detection) for IP-MRM assays ranged from 2.3 to 19%, which was similar to variation for ELISAs of the same samples. IP-MRM and ELISA measurements for all target proteins except ENG were highly correlated (r = 0.67–0.97). IP-MRM with high-quality capture antibodies thus provides an effective alternative method to ELISA for protein quantitation in biological fluids. PMID:24224610

  7. Poster - 28: Shielding of X-ray Rooms in Ontario in the Absence of Best Practice

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Frimeth, Jeff; Richer, Jeff; Nesbitt, James

    This poster will be strictly based on the Healing Arts Radiation Protection (HARP) Act, Regulation 543 under this Act (X-ray Safety Code), and personal communication the presenting author has had. In Ontario, the process of approval of an X-ray machine installation by the Director of the X-ray Inspection Service (XRIS) follows a certain protocol. Initially, the applicant submits a series of forms, including recommended shielding amounts, in order to satisfy the law. This documentation is then transferred to a third-party vendor (i.e. a professional engineer – P.Eng.) outsourced by the Ministry of Health and Long-term Care (MOHLTC). The P.Eng. thenmore » evaluates the submitted documentation for appropriate fulfillment of the HARP Act and Reg. 543 requirements. If the P.Eng.’s evaluation of the documentation is to their satisfaction, the XRIS is then notified. Finally, the Director will then issue a letter of approval to install the equipment at the facility. The methodology required to be used by the P.Eng. in order to determine the required amounts of protective barriers, and recommended to be used by the applicant, is contained within Safety Code 20A. However, Safety Code 35 has replaced the obsolete Safety Code 20A document and employs best practices in shielding design. This talk will focus further on specific intentions and limitations of Safety Code 20A. Furthermore, this talk will discuss the definition of the “practice of professional engineering” in Ontario. COMP members who are involved in shielding design are strongly encouraged to attend.« less

  8. On cuff imbalance and tripolar ENG amplifier configurations.

    PubMed

    Triantis, Iasonas F; Demosthenous, Andreas; Donaldson, Nick

    2005-02-01

    Electroneurogram (ENG) recording techniques benefit from the use of tripolar cuffs because they assist in reducing interference from sources outside the cuff. However, in practice the performance of ENG amplifier configurations, such as the quasi-tripole and the true-tripole, has been widely reported to be degraded due to the departure of the tripolar cuff from ideal behavior. This paper establishes the presence of cuff imbalance and investigates its relationship to cuff asymmetry, cuff end-effects and interference source proximity. The paper also presents a comparison of the aforementioned amplifier configurations with a new alternative, termed the adaptive-tripole, developed to automatically compensate for cuff imbalance. The output signal-to-interference ratio of the three amplifier configurations were compared in vivo for two interference signals (stimulus artifact and M-wave) superimposed on compound action potentials. The experiments showed (for the first time) that the two interference signals result in different cuff imbalance values. Nevertheless, even with two distinct cuff imbalances present, the adaptive-tripole performed better than the other two systems in 61.9% of the trials.

  9. Balance of antiangiogenic and angiogenic factors in the context of the etiology of preeclampsia.

    PubMed

    Seki, Hiroyuki

    2014-10-01

    The "two-stage disorder" theory that is assumed for the etiology of preeclampsia hypothesizes that antiangiogenic and angiogenic factors and/or placental debris play an important role in this disorder. The physiological actions of placental debris occur via the balance between antiangiogenic and angiogenic factors. Accordingly, this balance between antiangiogenic and angiogenic factors should be investigated to elucidate the various pathological features of preeclampsia. Their accurate evaluation is needed to investigate not only antiangiogenic factors (such as sFlt-1 and sEng) and angiogenic factors (such as vascular endothelial growth factor, placental growth factor and transforming growth factor-β) but also the expression level of their receptors such as Flt-1 and Eng. However, it is ethically and technically difficult to investigate the above-mentioned factors at antepartum in human patients. The examination of the ratios of sFlt-1/vascular endothelial growth factor receptor ligands and sEng/transforming vascular endothelial growth factor-β and the use of experimental animal models may help in elucidating various unresolved issues in preeclampsia. © 2014 Nordic Federation of Societies of Obstetrics and Gynecology.

  10. An ENG resonator-based microwave sensor for the characterization of aqueous glucose

    NASA Astrophysics Data System (ADS)

    Kumari, Ratnesh; Patel, Piyush N.; Yadav, Rahul

    2018-02-01

    This work proposes a microwave filter with a notched frequency of transmission using an epsilon negative (ENG) unit-cell resonator as a sensor device. The device finds important application for the characterization of life-saving samples such as glucose. The ENG structure consists of two complementary geometries in the shape of ring and horn. The structure efficiently inhibits the incoming RF signal and creates a stopband resonance at 2.074 GHz. The printed circuit board of the layout was realized using FR-4 substrate of relative permittivity ɛ r  =  4.4, and height of 1.6 mm. It is experimentally seen that in the complementary area of horn and circular ring, the glucose sample perturbs the air-dielectric fringing fields which exist over the complementary area and modifies the frequency of stopband resonance. A change in sensor resonance was recorded and calibrated for different concentrations of glucose sample. The sensor exhibits a linear response for glucose concentration ranging from 20 to 100 mg ml-1 in the sensing area.

  11. Are thiazides effective on hypertensive vertigo? A preliminary study.

    PubMed

    Eryaman, Esra; Gökcan, Gökçen; Parmaksız, Ergün; Acar, Nurhan Ozdemir; Ozlüoğlu, Levent Naci

    2012-01-01

    In this study, we aimed to investigate whether the symptoms of vertigo related to hypertension resulted from endolymphatic hydrops and the efficacy of the thiazides in the treatment. A total of 24 vertigo patients without peripheric or central vestibular pathologies or hyperlipidemia were included. The study group comprised 15 patients with hypertension, including nine with regulated non-insulin-dependent diabetes mellitus (DM). The control group comprised nine patients without hypertension or DM. The patients in the study group received hydrochlorothiazide treatment. The European Evaluation of Vertigo Scale (EEVS) and Vertigo Handicap Questionnaire (VHQ), puretone audiometry, tympanometry, electronystagmography (ENG) for nystagmus tests, oculomotor tests, and caloric test were carried out initially and at three weeks for both groups. The results of the study group were compared to those of the control group. There was a statistically significant decrease in the scores of EEVS and VHQ at three weeks in the study group, compared to the baseline scores (for both groups p≤0.01). Our study results showed that thiazides alleviated vertigo symptoms in hypertensive patients, as measured by qualitative methods (i.e. EEVS, VHQ), but not with quantitative measurements (i.e. ENG).

  12. Computer simulation of heterogeneous polymer photovoltaic devices

    NASA Astrophysics Data System (ADS)

    Kodali, Hari K.; Ganapathysubramanian, Baskar

    2012-04-01

    Polymer-based photovoltaic devices have the potential for widespread usage due to their low cost per watt and mechanical flexibility. Efficiencies close to 9.0% have been achieved recently in conjugated polymer based organic solar cells (OSCs). These devices were fabricated using solvent-based processing of electron-donating and electron-accepting materials into the so-called bulk heterojunction (BHJ) architecture. Experimental evidence suggests that a key property determining the power-conversion efficiency of such devices is the final morphological distribution of the donor and acceptor constituents. In order to understand the role of morphology on device performance, we develop a scalable computational framework that efficiently interrogates OSCs to investigate relationships between the morphology at the nano-scale with the device performance. In this work, we extend the Buxton and Clarke model (2007 Modelling Simul. Mater. Sci. Eng. 15 13-26) to simulate realistic devices with complex active layer morphologies using a dimensionally independent, scalable, finite-element method. We incorporate all stages involved in current generation, namely (1) exciton generation and diffusion, (2) charge generation and (3) charge transport in a modular fashion. The numerical challenges encountered during interrogation of realistic microstructures are detailed. We compare each stage of the photovoltaic process for two microstructures: a BHJ morphology and an idealized sawtooth morphology. The results are presented for both two- and three-dimensional structures.

  13. High Attenuation Rate for Shallow, Small Earthquakes in Japan

    NASA Astrophysics Data System (ADS)

    Si, Hongjun; Koketsu, Kazuki; Miyake, Hiroe

    2017-09-01

    We compared the attenuation characteristics of peak ground accelerations (PGAs) and velocities (PGVs) of strong motion from shallow, small earthquakes that occurred in Japan with those predicted by the equations of Si and Midorikawa (J Struct Constr Eng 523:63-70, 1999). The observed PGAs and PGVs at stations far from the seismic source decayed more rapidly than the predicted ones. The same tendencies have been reported for deep, moderate, and large earthquakes, but not for shallow, moderate, and large earthquakes. This indicates that the peak values of ground motion from shallow, small earthquakes attenuate more steeply than those from shallow, moderate or large earthquakes. To investigate the reason for this difference, we numerically simulated strong ground motion for point sources of M w 4 and 6 earthquakes using a 2D finite difference method. The analyses of the synthetic waveforms suggested that the above differences are caused by surface waves, which are predominant at stations far from the seismic source for shallow, moderate earthquakes but not for shallow, small earthquakes. Thus, although loss due to reflection at the boundaries of the discontinuous Earth structure occurs in all shallow earthquakes, the apparent attenuation rate for a moderate or large earthquake is essentially the same as that of body waves propagating in a homogeneous medium due to the dominance of surface waves.

  14. RF wave simulation for cold edge plasmas using the MFEM library

    NASA Astrophysics Data System (ADS)

    Shiraiwa, S.; Wright, J. C.; Bonoli, P. T.; Kolev, T.; Stowell, M.

    2017-10-01

    A newly developed generic electro-magnetic (EM) simulation tool for modeling RF wave propagation in SOL plasmas is presented. The primary motivation of this development is to extend the domain partitioning approach for incorporating arbitrarily shaped SOL plasmas and antenna to the TORIC core ICRF solver, which was previously demonstrated in the 2D geometry [S. Shiraiwa, et. al., "HISTORIC: extending core ICRF wave simulation to include realistic SOL plasmas", Nucl. Fusion in press], to larger and more complicated simulations by including a 3D realistic antenna and integrating RF rectified sheath potential model. Such an extension requires a scalable high fidelity 3D edge plasma wave simulation. We used the MFEM [http://mfem.org], open source scalable C++ finite element method library, and developed a Python wrapper for MFEM (PyMFEM), and then a radio frequency (RF) wave physics module in Python. This approach allows for building a physics layer rapidly, while separating the physics implementation being apart from the numerical FEM implementation. An interactive modeling interface was built on pScope [S Shiraiwa, et. al. Fusion Eng. Des. 112, 835] to work with an RF simulation model in a complicated geometry.

  15. Fetal ECG Extraction From Maternal Body Surface Measurement Using Independent Component Analysis

    DTIC Science & Technology

    2001-10-25

    Ibaraki 305-0901, Japan Abstract – A method applying independent component analysis (ICA) to detect the electrocardiogram of a prenatal cattle foetus is...monitoring the health status of an unborn cattle foetus is indispensable in preventing natural abortion and premature birth [3]. One of the applicable...and Y. Honda, “ECG and Heart Rate Detection of Prenatal Cattle Foetus Using Adaptive Digital Filtering,” World Congress on Med. Phys.& Biomed. Eng., Chicago TU-CXH-75, pp. 1-4, 2000.

  16. Assessment of Governor Control Parameter Settings of a Submarine Diesel Engine

    DTIC Science & Technology

    2013-03-01

    on the mean back pressure. The amplitude was 6.25 kPa (corresponding to a significant wave height of 1.25 m ) and a period of 7.4 s . The peak-peak...was 30 kPa (corresponding to a significant wave height of 6 m ) and a period of 10.3 s . The results are shown in Figure 17 to Figure 20. Comparison of... a loss in the system. Hopka et al. [9] obtain the ‘indicated torque’ from an empirical relationship  1 2 3 4 5 ,find f cc eng out in in eng m b

  17. Numerical study of magnetohydrodynamic viscous plasma flow in rotating porous media with Hall currents and inclined magnetic field influence

    NASA Astrophysics Data System (ADS)

    Bég, O. Anwar; Sim, Lik; Zueco, J.; Bhargava, R.

    2010-02-01

    A numerical solution is developed for the viscous, incompressible, magnetohydrodynamic flow in a rotating channel comprising two infinite parallel plates and containing a Darcian porous medium, the plates lying in the x-z plane, under constant pressure gradient. The system is subjected to a strong, inclined magnetic field orientated to the positive direction of the y-axis (rotational axis, normal to the x-z plane). The Navier-Stokes flow equations for a general rotating hydromagnetic flow are reduced to a pair of linear, viscous partial differential equations neglecting convective acceleration terms, for primary velocity (u‧) and secondary velocity (v‧) where these velocities are directed along the x and y axes. Only viscous terms are retained in the momenta equations. The model is non-dimensionalized and shown to be controlled by a number of dimensionless parameters. The resulting dimensionless ordinary differential equations are solved using a robust numerical method, Network Simulation Methodology. Full details of the numerics are provided. The present solutions are also benchmarked against the analytical solutions presented recently by Ghosh and Pop [Ghosh SK, Pop I. An analytical approach to MHD plasma behaviour of a rotating environment in the presence of an inclined magnetic field as compared to excitation frequency. Int J Appl Mech Eng 2006;11(4):845-856] for the case of a purely fluid medium (infinite permeability). We study graphically the influence of Hartmann number (Ha, magnetic field parameter), Ekman number (Ek, rotation parameter), Hall current parameter (Nh), Darcy number (Da, permeability parameter), pressure gradient (Np) and also magnetic field inclination (θ) on primary and secondary velocity fields. Additionally we investigate the effects of these multiphysical parameters on the dimensionless shear stresses at the plates. Both primary and secondary velocity are seen to be increased with a rise in Darcy number, owing to a simultaneous reduction in Darcian drag force. Primary velocity is seen to decrease with an increase in Hall current parameter (Nh) but there is a decrease in secondary velocity. The study finds important applications in magnetic materials processing, hydromagnetic plasma energy generators, magneto-geophysics and planetary astrophysics.

  18. A numerical study on the influence of the Portevin Le Chatelier effect on necking in an aluminium alloy

    NASA Astrophysics Data System (ADS)

    Hopperstad, O. S.; Børvik, T.; Berstad, T.; Lademo, O.-G.; Benallal, A.

    2007-10-01

    The constitutive relation proposed by McCormick (1988 Acta Metall. 36 3061-7) for materials exhibiting negative steady-state strain-rate sensitivity and the Portevin-Le Chatelier (PLC) effect is incorporated into an elastic-viscoplastic model for metals with plastic anisotropy. The constitutive model is implemented in LS-DYNA for corotational shell elements. Plastic anisotropy is taken into account by use of the yield criterion Yld2000/Yld2003 proposed by Barlat et al (2003 J. Plast. 19 1297-319) and Aretz (2004 Modelling Simul. Mater. Sci. Eng. 12 491-509). The parameters of the constitutive equations are determined for a rolled aluminium alloy (AA5083-H116) exhibiting negative steady-state strain-rate sensitivity and serrated yielding. The parameter identification is based on existing experimental data. A numerical investigation is conducted to determine the influence of the PLC effect on the onset of necking in uniaxial and biaxial tension for different overall strain rates. The numerical simulations show that the PLC effect leads to significant reductions in the strain to necking for both uniaxial and biaxial stress states. Increased surface roughness with plastic deformation is predicted for strain rates giving serrated yielding in uniaxial tension. It is likely that this is an important reason for the reduced critical strains. The characteristics of the deformation bands (orientation, width, velocity and strain rate) are also studied.

  19. Study of dispersive and nonlinear effects of coastal wave dynamics with a fully nonlinear potential flow model

    NASA Astrophysics Data System (ADS)

    Benoit, Michel; Yates, Marissa L.; Raoult, Cécile

    2017-04-01

    Efficient and accurate numerical models simulating wave propagation are required for a variety of engineering projects including the evaluation of coastal risks, the design of protective coastal structures, and the estimation of the potential for marine renewable energy devices. Nonlinear and dispersive effects are particularly significant in the coastal zone where waves interact with the bottom, the shoreline, and coastal structures. The main challenge in developing a numerical models is finding a compromise between computational efficiency and the required accuracy of the simulated wave field. Here, a potential approach is selected and the (fully nonlinear) water wave problem is formulated using the Euler-Zakharov equations (Zakharov, 1968) describing the temporal evolution of the free surface elevation and velocity potential. The proposed model (Yates and Benoit, 2015) uses a spectral approach in the vertical (i.e. the vertical variation of the potential is approximated by a linear combination of the first NT+1 Chebyshev polynomials, following the work of Tian and Sato (2008)). The Zakharov equations are integrated in time using a fourth-order Runge-Kutta scheme with a constant time step. At each sub-timestep, the Laplace Boundary Value Problem (BVP) is solved to estimate the free surface vertical velocity using the spectral approach, with typical values of NT between 5 to 8 for practical applications. The 1DH version of the code is validated with comparisons to the experimental data set of Becq-Girard et al. (1999), which studied the propagation of irregular waves over a beach profile with a submerged bar. The nonlinear and dispersive capacities of the model are verified with the correct representation of wave-wave interactions, in particular the transfer of energy between different harmonic components during wave propagation (analysis of the transformation of the variance spectrum along the channel). Evolution of wave skewness, asymmetry and kurtosis along the bathymetric profile also compare well with the measured values. The statistical distributions of the free surface elevation and wave height, calculated from the simulated time series, are compared to those of the measurements, with particular attention paid to the extreme waves. To use this model for realistic cases with complex bathymetric variations and multidirectional wave fields, the model has been extended to two horizontal dimensions (2DH). The spectral approach in the vertical dimension is retained, while the horizontal plane is discretized with scattered nodes to maintain the model's flexibility. The horizontal derivatives are estimated with finite-difference type formulas using Radial Basis Functions (Wright and Fornberg, 2006). The 2DH version of the code is applied to simulate the propagation of regular waves over a semi-circular step, which acts as a focusing lens. The simulation results are compared to the experimental data set of Whalin (1971). The evolution of the higher harmonic amplitudes in the shallow-water zone demonstrates the ability of the model to simulate wave propagation over complex 2DH coastal bathymetries. References: Becq-Girard F., Forget P., Benoit M. (1999) Non-linear propagation of unidirectional wave fields over varying topography. Coastal Eng., 38, 91-113. Tian Y., Sato S. (2008) A numerical model on the interaction between nearshore nonlinear waves and strong currents. Coast. Eng. Journal, 50(4), 369-395. Whalin R.W. (1971) The limit of applicability of linear wave refraction theory in a convergence zone. Technical report, DTIC Documents. Wright G.B., Fornberg B. (2006) Scattered node compact finite difference-type formulas generated from radial basis functions. J. Comp. Phys., 212, 99-123. Yates M.L., Benoit M. (2015) Accuracy and efficiency of two numerical methods of solving the potential flow problem for highly nonlinear and dispersive water waves. Int. J. Numer. Meth. Fluids, 77, 616-640. Zakharov V.E. (1968) Stability of periodic waves of finite amplitude on the surface of a deep fluid. J. Appl. Mech. Tech. Phys., 9(2), 190-194.

  20. Dislocation dynamics in non-convex domains using finite elements with embedded discontinuities

    NASA Astrophysics Data System (ADS)

    Romero, Ignacio; Segurado, Javier; LLorca, Javier

    2008-04-01

    The standard strategy developed by Van der Giessen and Needleman (1995 Modelling Simul. Mater. Sci. Eng. 3 689) to simulate dislocation dynamics in two-dimensional finite domains was modified to account for the effect of dislocations leaving the crystal through a free surface in the case of arbitrary non-convex domains. The new approach incorporates the displacement jumps across the slip segments of the dislocations that have exited the crystal within the finite element analysis carried out to compute the image stresses on the dislocations due to the finite boundaries. This is done in a simple computationally efficient way by embedding the discontinuities in the finite element solution, a strategy often used in the numerical simulation of crack propagation in solids. Two academic examples are presented to validate and demonstrate the extended model and its implementation within a finite element program is detailed in the appendix.

  1. The kinetics of heterogeneous nucleation and growth: an approach based on a grain explicit model

    NASA Astrophysics Data System (ADS)

    Rouet-Leduc, B.; Maillet, J.-B.; Denoual, C.

    2014-04-01

    A model for phase transitions initiated on grain boundaries is proposed and tested against numerical simulations: this approach, based on a grain explicit model, allows us to consider the granular structure, resulting in accurate predictions for a wide span of nucleation processes. Comparisons are made with classical models of homogeneous (JMAK: Johnson and Mehl 1939 Trans. Am. Inst. Min. Eng. 135 416; Avrami 1939 J. Chem. Phys. 7 1103; Kolmogorov 1937 Bull. Acad. Sci. USSR, Mat. Ser. 1 335) as well as heterogeneous (Cahn 1996 Thermodynamics and Kinetics of Phase Transformations Im et al (Pittsburgh: Materials Research Society)) nucleation. A transition scale based on material properties is proposed, allowing us to discriminate between random and site-saturated regimes. Finally, we discuss the relationship between an Avrami-type exponent and the transition regime, establishing conditions for its extraction from experiments.

  2. Circulating Angiogenic Factors and the Risk of Preeclampsia in Systemic Lupus Erythematosus Pregnancies.

    PubMed

    Leaños-Miranda, Alfredo; Campos-Galicia, Inova; Berumen-Lechuga, María Guadalupe; Molina-Pérez, Carlos José; García-Paleta, Yolanda; Isordia-Salas, Irma; Ramírez-Valenzuela, Karla Leticia

    2015-07-01

    To investigate whether angiogenic factors are associated with risk of developing preeclampsia in pregnant women with systemic lupus erythematosus (SLE). We performed a nested case-control study within a cohort of SLE women with singleton pregnancies. The study included 42 patients with SLE who eventually developed preeclampsia and 75 normal SLE pregnancies. Serum samples were collected at 4-week intervals (from weeks 12 to 36). Serum samples were analyzed for soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng). Women destined to develop preeclampsia had lower PlGF levels and higher sFlt-1 and sEng levels, and a higher sFlt-1/PlGF ratio than normal pregnancies. These changes became significant at 12 weeks in patients destined to develop either early onset (< 34 weeks, p ≤ 0.003) or late-onset preeclampsia (≥ 34 weeks, p ≤ 0.02). The risk to develop preeclampsia was higher among patients with PlGF concentration values in the lowest quartile or with sFlt-1 and sEng levels, and sFlt-1/PlGF ratio, in the highest quartile of the normal SLE pregnancies distribution. The OR were higher and appeared earlier in patients destined to develop early onset preeclampsia (OR ≥ 16.2, from Week 12 onward) than in patients who presented preeclampsia later (OR ≥ 8.9, from Week 24 onward). Changes in circulating concentrations of sFlt-1, PlGF, sEng, and the sFlt-1/PlGF ratio precede the onset of preeclampsia in SLE pregnancies. The risk profile of circulating angiogenic factors for developing preeclampsia distinctly evolves depending on whether this condition is manifested earlier or later.

  3. SMAD4 gene mutation increases the risk of aortic dilation in patients with hereditary haemorrhagic telangiectasia.

    PubMed

    Vorselaars, V M M; Diederik, A; Prabhudesai, V; Velthuis, S; Vos, J-A; Snijder, R J; Westermann, C J J; Mulder, B J; Ploos van Amstel, J K; Mager, J J; Faughnan, M E; Post, M C

    2017-10-15

    Mutations in the genes ENG, ACVRL1 and SMAD4 that are part of the transforming growth factor-beta signalling pathway cause hereditary haemorrhagic telangiectasia (HHT). Mutations in non-HHT genes within this same pathway have been found to associate with aortic dilation. Therefore, we investigated the presence of aortic dilation in a large cohort of HHT patients as compared to non-HHT controls. Chest computed tomography of consecutive HHT patients (ENG, ACVRL1 and SMAD4 mutation carriers) and non-HHT controls were reviewed. Aortic root dilation was defined as a z-score>1.96. Ascending and descending aorta dimensions were corrected for age, gender and body surface area. In total 178 subjects (57.3% female, mean age 43.9±14.9years) were included (32 SMAD4, 47 ENG, 50 ACVRL1 mutation carriers and 49 non-HHT controls). Aortopathy was present in a total of 42 subjects (24% of total). Aortic root dilatation was found in 31% of SMAD4, 2% of ENG, 6% of ACVRL1 mutation carriers, and 4% in non-HHT controls (p<0.001). The aortic root diameter was 36.3±5.2mm in SMAD4 versus 32.7±3.9mm in the non-SMAD4 group (p=0.001). SMAD4 was an independent predictor for increased aortic root (β-coefficient 3.5, p<0.001) and ascending aorta diameter (β-coefficient 1.6, p=0.04). SMAD4 gene mutation in HHT patients is independently associated with a higher risk of aortic root and ascending aortic dilation as compared to other HHT patients and non-HHT controls. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Comparing the curative efficacy of topical treatment with thiamphenicol and oxytetracycline on digital dermatitis lesions in dairy cattle.

    PubMed

    Holzhauer, M; Ploegmakers-van Deventer, R; Smits, D; Swart, W

    2017-05-20

    The efficacy of two topically applied antibiotics for the treatment of painful ulcerative stage of bovine digital dermatitis (BDD) lesions was compared in a clinical trial conducted on five dairy farms in the Netherlands during the autumn of 2015. A total of 109 cows with an ulcerative (M2) stage of BDD were randomly appointed a treatment with an antibiotic-based spray. One treatment contained thiamphenicol as active ingredient (TAF). The other treatment had oxytetracycline as active ingredient (ENG). The experimental unit for this study was the hind claw with the presence of an ulcerative BDD lesion. On day 0, claws with ulcerative BDD lesions were trimmed, cleaned, photographed and thereafter treated randomly either with TAF or ENG. Cure was defined as the transition of an ulcerative lesion into a non-painful chronic (M4) or into a healed (M0) stage of BDD at day 28 post-treatment. The cure rate at day 28 of M2 BDD lesions treated with TAF was 89 per cent (95 per cent CI 0.78 to 0.94), and for ENG 75 per cent (95 per cent CI 0.67 to 0.86). So the difference in cure rate was 14 per cent (95 per cent CI 0.00 to 0.27), which was statistically significant. The P value in this experiment is very close to 0.05 indicating that the effect is quite small. If a two-sided test would be used, the small significant effect, in this experiment, will disappear. Overall, the significant better curative effect of TAF on BDD M2 lesions was small, compared with ENG. British Veterinary Association.

  5. Erratum: Erratum: Denoising Phase Unwrapping Algorithm for Precise Phase Shifting Interferometry

    NASA Astrophysics Data System (ADS)

    Phuc, Phan Huy; Rhee, Hyug-Gyo; Ghim, Young-Sik

    2018-06-01

    This is a revision of the reference list reported in the original article. In order to clear the contribution of the previous work on the incremental breadth-first search (IBFS) method applied to the PUMA algorithm, we add one more reference to the existing reference list, as in this erratum. Page 83 : In this paper, we propose an algorithm that modifies the Boykov-Kolmogorov (BK) algorithm using the incremental breadth-first search (IBFS) method [27, 28] to find paths from the source to the sink of a graph. [28] S. Ali, H. Khan, I. Shaik and F. Ali, Int. J. Eng. and Technol. 7, 254 (2015).

  6. [An adjustment to the age structure of the Italian population in the 1971 census].

    PubMed

    Caselli, G; Golini, A; Capocaccia, R

    1989-01-01

    "Having verified, in the 1971 [Italian] census, the presence of certain anomalous data for cohorts born in 1900, 1911, 1920, 1924, 1930, 1936, 1940, 1948, 1950 and 1960, we assessed the size of the error and estimated the new population total which emerged both by age and year of birth. The method used [is similar] to more classical methods to correct biases in age structure in previous censuses and in those countries where the data available are somewhat lacking. The adjusted values, referring to Italy as a whole, are contained in the text...." (SUMMARY IN ENG AND FRE) excerpt

  7. Aircraft Alerting Systems Standardization Study. Volume I. Candidate System Validation and Time-Critical Display Evaluation.

    DTIC Science & Technology

    1981-01-01

    SELCAL FLT ALT ATNI AUO ALT BRK CANSELCAL OVSO CALL CONTRL ALRT _ I7CT be SPLR b 0 11CALL Figure 5.4.4-1 Pilot’s Response Panel Figure 5.4.4-2 Flight...Galley bus off 27 GLY BUS OFF A RP ELEC CYCLE SWITCH Utility bus off 28 UTIL BUS OFF A RP ELEC CYCLE SWITCH Right engine 29 R ENG HYD PUMP A RP HYD...CYCLE SWITCH hydraulic pump Left engine 30 L ENG FIRE DET A RP FIRE RP FIRE fire detector Left brake overheat 31 L BRAKE OVHT A RP BRK RP BRK Right

  8. Genetics of solvent-producing clostridia. Final technical report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    Specific Aims 1 and 2 of the original project proposal were specifically addressed during this project period. This involved the development of the pCAK1 phagemid delivery vector, refinement of the C. acetobutylicum electroporation protocol, selection and characterization of the engB cellulase gene from C. cellulovorans and the introduction and successful expression of this heterologous engB gene from C. cellulovorans in C. acetobutylicum. The successful expression of a heterologous engB gene from C. cellulovorans in C. acetobutylicum ATCC 824 has important industrial significance for the utilization of cellulose by this ABE fermentation microorganism. Conversion efficiency testing of the developed recombinant strainsmore » in batch and continuous culture (Specific Aim 3) will be carried out once suitable strains have been developed which can utilize cellulose as sole carbon source. The functionality of pCAK1 in the E. coli host system, especially in generating ssDNA, in the absence of impairing E. coli cell viability, together with successful introduction of pCAK1 into C. acetobutylicum and C. perfringens is the basis for the construction of a M13-like genetic system for the genus Clostridium and is expected to allow for more sophisticated molecular genetic analysis of this genus.« less

  9. AGM-88E Advanced Anti-Radiation Guided Missile (AGM-88E AARGM)

    DTIC Science & Technology

    2015-12-01

    0.0 0.0 Acq O&M 0.0 0.0 -- 0.0 0.0 0.0 0.0 Total 1528.5 1661.1 N/A 2107.4 1861.4 2026.2 2663.7 1 APB Breach Confidence Level Confidence Level of...normal conditions, encountering average levels of technical, schedule, and programmatic risk and external interference. Based on the rigor in methods...SAR Baseline to Current SAR Baseline (TY $M) Initial PAUC Development Estimate Changes PAUC Production Estimate Econ Qty Sch Eng Est Oth Spt Total

  10. [Estimation of infant and child mortality in the eastern provinces of Cuba].

    PubMed

    Gonzalez, G; Herrera, L

    1986-01-01

    An estimate of infant and child mortality in the eastern provinces of Cuba is presented using the Brass method as adapted by Trussell. "Estimations by urban and rural zones are also performed within the provinces studied, and results are compared with those possible to obtain by continuous statistics. Results obtained show that in the eastern [part] of the country Holguin and Guantanamo are the provinces with highest infantile mortality rates, and the lowest rates correspond to Granma, followed by Santiago de Cuba." (SUMMARY IN ENG AND FRE) excerpt

  11. A multilayer shallow water system for polydisperse sedimentation

    NASA Astrophysics Data System (ADS)

    Fernández-Nieto, E. D.; Koné, E. H.; Morales de Luna, T.; Bürger, R.

    2013-04-01

    This work considers the flow of a fluid containing one disperse substance consisting of small particles that belong to different species differing in size and density. The flow is modelled by combining a multilayer shallow water approach with a polydisperse sedimentation process. This technique allows one to keep information on the vertical distribution of the solid particles in the mixture, and thereby to model the segregation of the particle species from each other, and from the fluid, taking place in the vertical direction of the gravity body force only. This polydisperse sedimentation process is described by the well-known Masliyah-Lockett-Bassoon (MLB) velocity functions. The resulting multilayer sedimentation-flow model can be written as a hyperbolic system with nonconservative products. The definitions of the nonconservative products are related to the hydrostatic pressure and to the mass and momentum hydrodynamic transfer terms between the layers. For the numerical discretization a strategy of two steps is proposed, where the first one is also divided into two parts. In the first step, instead of approximating the complete model, we approximate a reduced model with a smaller number of unknowns. Then, taking advantage of the fact that the concentrations are passive scalars in the system, we approximate the concentrations of the different species by an upwind scheme related to the numerical flux of the total concentration. In the second step, the effect of the transference terms defined in terms of the MLB model is introduced. These transfer terms are approximated by using a numerical flux function used to discretize the 1D vertical polydisperse model, see Bürger et al. [ R. Bürger, A. García, K.H. Karlsen, J.D. Towers, A family of numerical schemes for kinematic flows with discontinuous flux, J. Eng. Math. 60 (2008) 387-425]. Finally, some numerical examples are presented. Numerical results suggest that the multilayer shallow water model could be adequate in situations where the settling takes place from a suspension that undergoes horizontal movement.

  12. A high-throughput screen of the GTPase activity of Escherichia coli EngA to find an inhibitor of bacterial ribosome biogenesis

    PubMed Central

    Bharat, Amrita; Blanchard, Jan E.; Brown, Eric D.

    2014-01-01

    The synthesis of ribosomes is an essential process, which is aided by a variety of transacting factors in bacteria. Among these is a group of GTPases essential for bacterial viability and emerging as promising targets for new antibacterial agents. Herein, we describe a robust high-throughput screening process for inhibitors of one such GTPase, the Escherichia coli EngA protein. The primary screen employed an assay of phosphate production in 384-well density. Reaction conditions were chosen to maximize sensitivity for the discovery of competitive inhibitors while maintaining a strong signal amplitude and low noise. In a pilot screen of 31,800 chemical compounds, 44 active compounds were identified. Further, we describe the elimination of non-specific inhibitors that were detergent-sensitive or reactive as well as those that interfered with the high-throughput phosphate assay. Four inhibitors survived these common counter-screens for non-specificity but these chemicals were also inhibitors of the unrelated enzyme dihydrofolate reductase, suggesting that they too were promiscuously active. The high-throughput screen of the EngA protein described here provides a meticulous pilot study in the search for specific inhibitors of GTPases involved in ribosome biogenesis. PMID:23606650

  13. Addressing Loss of Efficiency Due to Misclassification Error in Enriched Clinical Trials for the Evaluation of Targeted Therapies Based on the Cox Proportional Hazards Model.

    PubMed

    Tsai, Chen-An; Lee, Kuan-Ting; Liu, Jen-Pei

    2016-01-01

    A key feature of precision medicine is that it takes individual variability at the genetic or molecular level into account in determining the best treatment for patients diagnosed with diseases detected by recently developed novel biotechnologies. The enrichment design is an efficient design that enrolls only the patients testing positive for specific molecular targets and randomly assigns them for the targeted treatment or the concurrent control. However there is no diagnostic device with perfect accuracy and precision for detecting molecular targets. In particular, the positive predictive value (PPV) can be quite low for rare diseases with low prevalence. Under the enrichment design, some patients testing positive for specific molecular targets may not have the molecular targets. The efficacy of the targeted therapy may be underestimated in the patients that actually do have the molecular targets. To address the loss of efficiency due to misclassification error, we apply the discrete mixture modeling for time-to-event data proposed by Eng and Hanlon [8] to develop an inferential procedure, based on the Cox proportional hazard model, for treatment effects of the targeted treatment effect for the true-positive patients with the molecular targets. Our proposed procedure incorporates both inaccuracy of diagnostic devices and uncertainty of estimated accuracy measures. We employed the expectation-maximization algorithm in conjunction with the bootstrap technique for estimation of the hazard ratio and its estimated variance. We report the results of simulation studies which empirically investigated the performance of the proposed method. Our proposed method is illustrated by a numerical example.

  14. Downscattered Neutron Imaging for ICF

    NASA Astrophysics Data System (ADS)

    Moran, Michael; Haan, Steven; Hatchett, Stephen; Izumi, Nobuhiko; Koch, Jeffrey; Lerche, Richard; Phillips, Thomas

    2002-11-01

    Diagnostics which measure the performance of implosions are critical for the success of ignition. Neutron yield, fusion-burn time history, and images are examples of important diagnostics. Neutron and x-ray images will record the geometries of compressed targets during the fusion-burn process. Such images provide a critical test of the accuracy of numerical modeling of ICF experiments. Imaging of downscattered neutrons, by using energy-resolved detection, offers the intriguing advantage of being able to provide independent images of burning and non-burning regions of the nuclear fuel. The usefulness of downscattered neutron imaging depends on both the information content of the data and on the quality of the data that can be recorded. The information content will relate to the characteristic neutron spectra that are associated with emission from different regions of the source. Numerical modeling of ICF fusion burn will be required to interpret the corresponding energy-dependent images. The exercise will be useful only if the images can be recorded with sufficient definition to reveal the spatial and energy-dependent features of interest. Several options are being evaluated with respect to the feasibility of providing the desired simultaneous spatial and energy resolution. This work was performed under the auspices of the U.S. Department of Energy by the University of California, Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48.

  15. Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload.

    PubMed

    Kapur, Navin K; Qiao, Xiaoying; Paruchuri, Vikram; Mackey, Emily E; Daly, Gerard H; Ughreja, Kishan; Ughreja, Keshan; Morine, Kevin J; Levine, Jonathan; Aronovitz, Mark J; Hill, Nicholas S; Jaffe, Iris Z; Letarte, Michelle; Karas, Richard H

    2014-07-11

    Right ventricular (RV) failure is a major cause of mortality worldwide and is often a consequence of RV pressure overload (RVPO). Endoglin is a coreceptor for the profibrogenic cytokine, transforming growth factor beta 1 (TGF-β1). TGF-β1 signaling by the canonical transient receptor protein channel 6 (TRPC-6) was recently reported to stimulate calcineurin-mediated myofibroblast transformation, a critical component of cardiac fibrosis. We hypothesized that reduced activity of the TGF-β1 coreceptor, endoglin, limits RV calcineurin expression and improves survival in RVPO. We first demonstrate that endoglin is required for TGF-β1-mediated calcineurin/TRPC-6 expression and up-regulation of alpha-smooth muscle antigen (α-SMA), a marker of myofibroblast transformation, in human RV fibroblasts. Using endoglin haploinsufficient mice (Eng(+/-)) we show that reduced endoglin activity preserves RV function, limits RV fibrosis, and attenuates activation of the calcineurin/TRPC-6/α-SMA pathway in a model of angio-obliterative pulmonary hypertension. Next, using Eng(+/-) mice or a neutralizing antibody (Ab) against endoglin (N-Eng) in wild-type mice, we show that reduced endoglin activity improves survival and attenuates RV fibrosis in models of RVPO induced by pulmonary artery constriction. To explore the utility of targeting endoglin, we observed a reversal of RV fibrosis and calcineurin levels in wild-type mice treated with a N-Eng Ab, compared to an immunoglobulin G control. These data establish endoglin as a regulator of TGF-β1 signaling by calcineurin and TRPC-6 in the RV and identify it as a potential therapeutic target to limit RV fibrosis and improve survival in RVPO, a common cause of death in cardiac and pulmonary disease. © 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  16. Tripolar-cuff deviation from ideal model: assessment by bioelectric field simulations and saline-bath experiments.

    PubMed

    Triantis, Iasonas F; Demosthenous, Andreas

    2008-06-01

    Ideally, interference in neural measurements due to signals from nearby muscles can be completely eliminated with the use of tripolar cuffs, in combination with appropriate amplifier configurations, such as the quasi-tripole (QT) and the true-tripole (TT). The operation of these amplifiers, is based on the theoretical property of the nerve cuff to produce a linear relationship of potential versus distance along its length, internally, when external potentials appear between its ends. Thus, in principle, electroneurogram (ENG) recordings from an ideal tripolar cuff would be free from electromyogram (EMG) interference generated by nearby muscles. However, in practice the cuff exhibits non-ideal behaviour leading to "cuff imbalance". The main focus of this paper is to investigate the causes of cuff imbalance, to demonstrate that it should be incorporated as a main parameter in the theoretical ENG-recording cuff electrode model. In addition to cuff asymmetry and tissue growth, the proximity of the interference source to the cuff is shown to result in cuff imbalance. The influence of proximity imbalance on the performance of the QT and TT amplifiers is also considered. Proximity imbalance is studied using bioelectric field simulations and saline-bath experiments. Variation is observed with both distance (40 mm and 70 mm was examined) and orientation (0-180 degrees), with the latter causing a more severe effect especially when the source dipole and the cuff are vertical to each other. The simulations and measurements are in close agreement. Tissue growth imbalance and asymmetry imbalance are also investigated in vitro. Finally, the signal-to-interference ratio (SIR; ENG/EMG) of the QT and TT amplifiers is examined in the presence of cuff imbalance. It is shown that proximity imbalance results in their SIR to peak only at certain cuff orientation values. This important finding offers an insight as to why in practice ENG recordings using these amplifiers have been widely reported to be degraded by EMG interference.

  17. Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity

    PubMed Central

    Zhu, Wan; Shen, Fanxia; Mao, Lei; Zhan, Lei; Kang, Shuai; Sun, Zhengda; Nelson, Jeffrey; Zhang, Rui; Zou, Dingquan; McDougall, Cameron M.; Lawton, Michael T.; Vu, Thiennu H.; Wu, Zhijian; Scaria, Abraham; Colosi, Peter; Forsayeth, John; Su, Hua

    2017-01-01

    Background and Purpose Brain arteriovenous malformation (bAVM) is an important risk factor for intracranial hemorrhage. Current therapies are associated with high morbidities. Excessive vascular endothelial growth factor (VEGF) has been implicated in bAVM pathophysiology. Because soluble FLT1 binds to VEGF with high affinity, we tested intravenous (IV) delivery of an adeno-associated viral vector serotype 9 expressing soluble FLT1 (AAV9-sFLT1) to alleviate the bAVM phenotype. Methods Two mouse models were used. Model 1: bAVM was induced in R26CreER;Eng2f/2f mice through global Eng gene deletion and brain focal angiogenic stimulation; AAV2-sFLT02 (an AAV expressing a shorter form of sFLT1) was injected into the brain at the time of model induction, and AAV9-sFLT1, IV-injected eight weeks after. Model 2: SM22αCre;Eng2f/2f mice had a 90% occurrence of spontaneous bAVM at 5 weeks of age and 50% mortality at 6 weeks; AAV9-sFLT1 was IV-delivered into 4–5-week-old mice. Tissue samples were collected four weeks after AAV9-sFLT1 delivery. Results AAV2-sFLT02 inhibited bAVM formation and AAV9-sFLT1 reduced abnormal vessels in Model 1 (GFP vs sFLT1: 3.66 ± 1.58/200 vessels vs 1.98 ± 1.29, p<0.05). AAV9-sFLT1 reduced the occurrence of bAVM (GFP vs sFLT1: 100% vs 36%) and mortality [GFP vs sFLT1: 57% (12/22 mice) vs 24% (4/19 mice), p<0.05] in Model 2. Kidney and liver function did not change significantly. Minor liver inflammation was found in 56% of AAV9-sFLT1-treated Model 1 mice. Conclusion By applying a regulated mechanism to restrict sFLT1 expression to bAVM, AAV9-sFLT1 can potentially be developed into a safer therapy to reduce the bAVM severity. PMID:28325846

  18. Research and Development of Methods for Estimating Physicochemical Properties of Organic Compounds of Environmental Concern. Part 2.

    DTIC Science & Technology

    1981-06-01

    they be used outside the temperature range of 10 to 40°C. See J. Gmehling et al., Ind. Eng. Chem. Process Des. Dev., 21:118 (1982) for new set of para ...Mumford, S.A. and J.W.C. Phillips, "The Evaluation and Interpretation of Para - chors," J. Chem. Soc., 1929, 2112-33. 20. Ogata, Y. and M. Tsuchida...naphthylamnines 1.03 a. For mixed systems, Kr for the OH group takes precedence. Thus, KF for P- aminophenol is 1.15. Source: Fishtine [4]. (4) Assume A&b

  19. Comment on `A novel experimental method: Electrochemical detection of phase transition in ferroelectric single crystals', Chem. Phys. Lett. 384 (2004) 262 by K. Gatner and R. Jakubas

    NASA Astrophysics Data System (ADS)

    Ćwikiel, K.; Matlak, M.

    2006-03-01

    We comment the Letter 'A novel experimental method: electrochemical detection of phase transition in ferroelectric single crystals', Chem. Phys. Lett. 384 (2004) 262 by K. Gatner and R. Jakubas. We indicate that the method used in this Letter is not 'A novel method' but the application of the method described in Refs. [M. Matlak, M. Pietruszka, E. Rówiński, Phys. Rev. B 63 (2001) 52101; M. Matlak, M. Pietruszka, E. Rówiński, Phys. Stat. Sol. A 184 (2001) 335; W. Gaweł, E. Zaleska, Z. Sztuba, Met. Sci. Eng. A 324 (2002) 255], well known to Gatner, but not cited in the commented Letter. Additionally Gatner, cooperating with us, has used our TGS samples and published the results in the commented Letter without our knowledge and permission.

  20. Using ambient vibration measurements for risk assessment at an urban scale: from numerical proof of concept to Beirut case study (Lebanon)

    NASA Astrophysics Data System (ADS)

    Salameh, Christelle; Bard, Pierre-Yves; Guillier, Bertrand; Harb, Jacques; Cornou, Cécile; Gérard, Jocelyne; Almakari, Michelle

    2017-04-01

    Post-seismic investigations repeatedly indicate that structures having frequencies close to foundation soil frequencies exhibit significantly heavier damages (Caracas 1967; Mexico 1985; Pujili, Ecuador 1996; L'Aquila 2009). However, observations of modal frequencies of soils and buildings in a region or within a current seismic risk analysis are not fully considered together, even when past earthquakes have demonstrated that coinciding soil and building frequencies leads to greater damage. The present paper thus focuses on a comprehensive numerical analysis to investigate the effect of coincidence between site and building frequencies. A total of 887 realistic soil profiles are coupled with a set of 141 single-degree-of-freedom elastoplastic oscillators, and their combined (nonlinear) response is computed for both linear and nonlinear soil behaviors, for a large number (60) of synthetic input signals with various PGA levels and frequency contents. The associated damage is quantified on the basis of the maximum displacement as compared to both yield and ultimate post-elastic displacements, according to the RISK-UE project recommendations (Lagomarsino and Giovinazzi in Bull Earthq Eng 4(4):415-443, 2006), and compared with the damage obtained in the case of a similar building located on rock. The correlation between this soil/rock damage increment and a number of simplified mechanical and loading parameters is then analyzed using a neural network approach. The results emphasize the key role played by the building/soil frequency ratio even when both soil and building behave nonlinearly; other important parameters are the PGA level, the soil/rock velocity contrast and the building ductility. A numerical investigation based on simulation of ambient noise for the whole set of 887 profiles also indicates that the amplitude of H/ V ratio may be considered as a satisfactory proxy for site amplification when applied to measurements at urban scale. A very easy implementation of this method, using ambient vibration measurements both at ground level and within buildings, is illustrated with an example application for the city of Beirut (Lebanon).[Figure not available: see fulltext.

  1. Pulsed Flow Pinch

    NASA Astrophysics Data System (ADS)

    Hartman, Charles

    2005-10-01

    Formation of a Pulsed Flow Pinch is discussed, based on 2-D, MHD numerical calculations. The PFP utilizes the observed stable, Btheta magnetic ``bubble'' which propagates from breach to muzzle during the run-down phase of the coaxial Marshall gun. We consider two ways of launching a PFP onto a fiber or cylindrical gas cloud: 1) by propagating the bubble to small radius along an exponentially-decreasing-radius center conductor and, 2) by a radial launch to form reflex PFP's propagating in opposite directions along a fiber. We show that the bubble velocity increases to high values as the radius is decreased making the rise time of Btheta at an axial point very short. A bubble, launched into uniform gas is found to undergo unstable pinching of the front. Results will be presented of calculations of a PFP driven, neutron-producing, snow-plow pinch. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48.

  2. Optimal lot sizing in screening processes with returnable defective items

    NASA Astrophysics Data System (ADS)

    Vishkaei, Behzad Maleki; Niaki, S. T. A.; Farhangi, Milad; Rashti, Mehdi Ebrahimnezhad Moghadam

    2014-07-01

    This paper is an extension of Hsu and Hsu (Int J Ind Eng Comput 3(5):939-948, 2012) aiming to determine the optimal order quantity of product batches that contain defective items with percentage nonconforming following a known probability density function. The orders are subject to 100 % screening process at a rate higher than the demand rate. Shortage is backordered, and defective items in each ordering cycle are stored in a warehouse to be returned to the supplier when a new order is received. Although the retailer does not sell defective items at a lower price and only trades perfect items (to avoid loss), a higher holding cost incurs to store defective items. Using the renewal-reward theorem, the optimal order and shortage quantities are determined. Some numerical examples are solved at the end to clarify the applicability of the proposed model and to compare the new policy to an existing one. The results show that the new policy provides better expected profit per time.

  3. Embryonic expression of the transforming growth factor beta ligand and receptor genes in chicken.

    PubMed

    Cooley, James R; Yatskievych, Tatiana A; Antin, Parker B

    2014-03-01

    Transforming growth factor-beta (TGFβ) signaling regulates a myriad of biological processes during embryogenesis, in the adult, and during the manifestation of disease. TGFβ signaling is propagated through one of three TGFβ ligands interacting with Type I and Type II receptors, and Type III co-receptors. Although TGFβ signaling is regulated partly by the combinatorial expression patterns of TGFβ receptors and ligands, a comprehensive gene expression analysis has not been published. Here we report the embryonic mRNA expression patterns in chicken embryos of the canonical TGFβ ligands (TGFB1, TGFB2, and TGFB3) and receptors (TGFBR1, TGFBR2, TGFBR3), plus the Activin A receptor, type 1 (ACVR1) and co receptor Endoglin (ENG) that also transduce TGFβ signaling. TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures. Integrating expression information identifies combinations of ligands and receptors that are involved in specific developmental processes including somitogenesis, cardiogenesis and vasculogenesis. Copyright © 2013 Wiley Periodicals, Inc.

  4. Modelling of masonry infill walls participation in the seismic behaviour of RC buildings using OpenSees

    NASA Astrophysics Data System (ADS)

    Furtado, André; Rodrigues, Hugo; Arêde, António

    2015-06-01

    Recent earthquakes show that masonry infill walls should be taken into account during the design and assessment process of structures, since this type of non-structural elements increase the in-plane stiffness of the structure and consequently the natural period. An overview of the past researches conducted on the modelling of masonry infilled frame issues has been done, with discussion of past analytical investigations and different modelling approaches that many authors have proposed, including micro- and macro-modelling strategies. After this, the present work presents an improved numerical model, based on the Rodrigues et al. (J Earthq Eng 14:390-416, 2010) approach, for simulating the masonry infill walls behaviour in the computer program OpenSees. The main results of the in-plane calibration analyses obtained with one experimental test are presented and discussed. For last, two reinforced concrete regular buildings were studied and subjected to several ground motions, with and without infills' walls.

  5. Invasive urodynamic testing prior to surgical treatment for stress urinary incontinence in women: cost-effectiveness and value of information analyses in the context of a mixed methods feasibility study.

    PubMed

    Homer, Tara; Shen, Jing; Vale, Luke; McColl, Elaine; Tincello, Douglas G; Hilton, Paul

    2018-01-01

    INVESTIGATE-I (INVasive Evaluation before Surgical Treatment of Incontinence Gives Added Therapeutic Effect?) was a mixed methods study to assess the feasibility of a future randomised controlled trial of invasive urodynamic testing (IUT) prior to surgery for stress urinary incontinence (SUI) in women. Here we report one of the study's five components, with the specific objectives of (i) exploring the cost-effectiveness of IUT compared with clinical assessment plus non-invasive tests (henceforth described as 'IUT' and 'no IUT' respectively) in women with SUI or stress-predominant mixed urinary incontinence (MUI) prior to surgery, and (ii) determining the expected net gain (ENG) from additional research. Study participants were women with SUI or stress-predominant MUI who had failed to respond to conservative treatments recruited from seven UK urogynaecology and female urology units. They were randomised to receive either 'IUT' or 'no IUT' before undergoing further treatment. Data from 218 women were used in the economic analysis. Cost utility, net benefit and value of information (VoI) analyses were performed within a randomised controlled pilot trial. Costs and quality-adjusted life years (QALYs) were estimated over 6 months to determine the incremental cost per QALY of 'IUT' compared to 'no IUT'. Net monetary benefit informed the VoI analysis. The VoI estimated the ENG and optimal sample size for a future definitive trial. At 6 months, the mean difference in total average cost was £138 ( p  = 0.071) in favour of 'IUT'; there was no difference in QALYs estimated from the SF-12 (difference 0.004; p  = 0.425) and EQ-5D-3L (difference - 0.004; p  = 0.725); therefore, the probability of IUT being cost-effective remains uncertain. The estimated ENG was positive for further research to address this uncertainty with an optimal sample size of 404 women. This is the largest economic evaluation of IUT. On average, up to 6 months after treatment, 'IUT' may be cost-saving compared to 'no IUT' because of the reduction in surgery following invasive investigation. However, uncertainty remains over the probability of 'IUT' being considered cost-effective, especially in the longer term. The VoI analysis indicated that further research would be of value. ISRCTN. ISRCTN71327395. Registered 7 June 2010.

  6. Retrospective analysis of serum and nasal mucus from cattle in Northern Ireland for evidence of infection with influenza A virus.

    PubMed

    Graham, D A; Calvert, V; McLaren, E

    2002-02-16

    Eighty-four pairs of acute and convalescent serum samples collected in 1998 and 1999 from 17 outbreaks of respiratory disease, milk drop syndrome or diarrhoea in cattle were tested by haemagglutination inhibition against human influenza viruses A/Eng/333/80 (HIN1) and A/Eng/427/88 (H3N2). Antibodies to these viruses were present in the convalescent sera of 56.5 per cent and 58.8 per cent cattle tested, respectively, with 56 per cent of the animals seroconverting to one or both viruses. Titres were typically higher to A/Eng/427/88 (H3N2). Further testing of a subset of 21 of these serum pairs against the predominant H1N1 and H3N2 human and porcine strains circulating when the samples were collected revealed that the highest reactivity, in terms of both the magnitude of the recorded titres and the number of positive sera, was to human H3N2 strains. The titres to human H1N1 strains and to both porcine subtypes were low or absent. Attempts to isolate influenza A virus from nasal mucus or swab samples from 142 cattle from 46 cases of respiratory disease and/or milk drop syndrome by passage in embryonated specific pathogen-free eggs were unsuccessful.

  7. A multicenter phase IIb study of a novel combination of intramuscular androgen (testosterone decanoate) and oral progestogen (etonogestrel) for male hormonal contraception.

    PubMed

    Hay, Cathy J; Brady, Brian M; Zitzmann, Michael; Osmanagaoglu, Kaan; Pollanen, Pasi; Apter, Dan; Wu, Frederick C W; Anderson, Richard A; Nieschlag, Eberhard; Devroey, Paul; Huhtaniemi, Ilpo; Kersemaekers, Wendy M

    2005-04-01

    The effect of a novel combination of oral etonogestrel (ENG) and im testosterone decanoate (TD) on suppression of gonadotropins and spermatogenesis as a potential lead for male contraception was investigated. Healthy male volunteers were randomized into two groups receiving 300 microg ENG daily and 400 mg TD every 4 (n = 55) or 6 (n = 57) wk for 48 wk. At wk 48, all men except one in the 6-wk group suppressed sperm concentration to less than 1 million/ml. Faster suppression occurred in the 4-wk group. Gonadotropins were suppressed in both groups and most consistently in the 4-wk group. During treatment, trough testosterone levels increased into the normal range in the 4-wk group but remained just below normal in the 6-wk group. All peak levels were within the normal range. After treatment cessation, recovery of sperm counts and gonadotropins to normal levels occurred in both groups. Minor effects on weight and cholesterol were noted. Fourteen subjects withdrew because of an adverse event with those possibly related to the study medication reported more frequently in the 6-wk group (nine vs. one). In conclusion, the combination of 300 microg ENG with 400 mg TD every 4 wk was superior in terms of efficacy, hormone profiles, and safety. This represents a promising approach to male hormonal contraception.

  8. Dizziness

    MedlinePlus

    ... help walking when you have a loss of balance during a vertigo attack. Avoid bright lights, TV, ... include: Blood pressure reading Electrocardiogram ( ECG ) Hearing tests Balance testing ( ENG ) Magnetic Resonance Imaging (MRI) Your provider ...

  9. [The prospects for the development of human resources in Indonesia].

    PubMed

    Swasono, Y; Boediono

    1990-12-01

    Human resource development and associated policies are examined for Indonesia. The authors discuss the importance of education, health, women's status, population policy, and employment opportunities. (SUMMARY IN ENG)

  10. Radiation arteriopathy in the transgenic arteriovenous fistula model.

    PubMed

    Lawton, Michael T; Arnold, Christine M; Kim, Yung J; Bogarin, Ernesto A; Stewart, Campbell L; Wulfstat, Amanda A; Derugin, Nikita; Deen, Dennis; Young, William L

    2008-05-01

    The transgenic arteriovenous fistula model, surgically constructed with transgenic mouse aorta interposed in common carotid artery-to-external jugular vein fistulae in nude rats, has a 4-month experimental window because patency and transgenic phenotype are lost over time. We adapted this model to investigate occlusive arteriopathy in brain arteriovenous malformations after radiosurgery by radiating grafted aorta before insertion in the fistula. We hypothesized that high-dose radiation would reproduce the arteriopathy observed clinically within the experimental time window and that deletions of endoglin (ENG) and endothelial nitric oxide synthase (eNOS) genes would modify the radiation response. Radiation arteriopathy in the common carotid arteries of 171 wild-type mice was examined with doses of 25, 80, 120, or 200 Gy (Experiment 1). Radiation arteriopathy in 68 wild-type arteriovenous fistulae was examined histologically and morphometrically with preoperative radiation doses of 0, 25, or 200 Gy (Experiment 2). Radiation arteriopathy in 51 transgenic arteriovenous fistulae (36 ENG and 15 eNOS knock-out fistulae) was examined using preoperative radiation doses of 0, 25, or 200 Gy (Experiment 3). High-dose radiation (200 Gy) of mouse common carotid arteries induced only mild arteriopathy (mean score, 0.66) without intimal hyperplasia and with high mortality (68%). Radiation arteriopathy in wild-type arteriovenous fistulae was severe (mean score, 3.5 at 200 Gy), with intimal hyperplasia and medial disruption at 3 months, decreasing luminal areas with increasing dose, and no mortality. Arteriopathy was robust in transgenic arteriovenous fistulae with ENG +/- and with eNOS +/-, with thick intimal hyperplasia in the former and distinct smooth muscle cell proliferation in the latter. The transgenic arteriovenous fistula model can be adapted to rapidly reproduce radiation arteriopathy observed in resected brain arteriovenous malformations after radiosurgery. High radiation doses accelerate the progression of arteriopathy to fit the 4-month time limitation of the model, allowing transgenic tissues to retain their phenotypes throughout the experimental window. Modified radiation responses in ENG and eNOS knock-out fistulae indicate that arteriopathy after arteriovenous malformation radiosurgery might potentially be enhanced by altered gene expression.

  11. Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglin.

    PubMed

    Tannetta, Dionne S; Dragovic, Rebecca A; Gardiner, Chris; Redman, Christopher W; Sargent, Ian L

    2013-01-01

    The placental syncytiotrophoblast releases micro and nanovesicles (STBM), into the maternal circulation in normal pregnancy and in increased amounts in pre-eclampsia (PE), which have proinflammatory and antiangiogenic activity and are implicated in PE pathophysiology. Better characterisation of STBM is essential to understand their role in PE. STBM prepared by placental lobe dual perfusion (pSTBM) and mechanical disruption (mSTBM) were analysed by four colour flow cytometry (4CFC), nanoparticle tracking analysis (NTA) and Western blotting to determine vesicle size, purity and Flt-1 and endoglin (Eng) expression. Biological activity of STBM associated Flt-1 and endoglin was assessed by the ability of VEGF, PlGF and TGFβ to bind to mSTBM and inhibit mSTBM induced endothelial monolayer disruption. STBM content was consistently high (~87-95%) across the different preparations. However, surface antigen intensities differed, with significantly lower placental alkaline phosphatase (P<0.05) and Eng (P<0.05) expression on mSTBM, and Flt-1 (P<0.05) expression on pSTBM. For PE placenta derived preparations, pSTBM contained lower Eng positive STBM (P<0.05) and mSTBM Eng expression was increased (P<0.05). Western blotting revealed increased Flt-1/sFlt-1 (P<0.02) and decreased placental alkaline phosphatase (P = 0.0002) content of PE placenta pSTBM. Using NTA, perfused PE placentas released significantly larger MV (P<0.001). Finally, VEGF, PlGF and TGFβ bound to mSTBM at physiologically relevant concentrations and inhibited mSTBM induced endothelial disruption (P<0.05-P<0.001). This study has found differences in physical and antigenic characteristics of normal and PE placenta STBM preparations produced by placental perfusion or mechanical disruption. We have also demonstrated that large quantities of biologically active STBM associated endoglin and Flt-1/sFlt-1 could contribute to the increased circulating levels measured in PE patients and add to the perturbation of the maternal vascular endothelium, normally attributed to non-membrane bound sFlt-1 and sEndoglin.

  12. Synthesis, characterization, shrinkage and curing kinetics of a new low-shrinkage urethane dimethacrylate monomer for dental applications.

    PubMed

    Atai, Mohammad; Ahmadi, Mehdi; Babanzadeh, Samal; Watts, David C

    2007-08-01

    The aim of the study was to synthesize and characterize an isophorone-based urethane dimethacrylate (IP-UDMA) resin-monomer and to investigate its shrinkage and curing kinetics. The IP-UDMA monomer was synthesized through the reaction of polyethylene glycol 400 and isophorone diisocyanate followed by reacting with HEMA to terminate it with methacrylate end groups. The reaction was followed using a standard back titration method and FTIR spectroscopy. The final product was purified and characterized using FTIR, (1)H NMR, elemental analysis and refractive index measurement. The shrinkage-strain of the specimens photopolymerized at circa 700mW/cm(2) was measured using the bonded-disk technique at 23, 35, and 45 degrees C. Initial shrinkage-strain-rates were obtained by numerical differentiation of shrinkage-strain data with respect to time. Degree-of-conversion of the specimens was measured using FTIR spectroscopy. The thermal curing kinetics of the monomer were also studied by differential scanning calorimetry (DSC). The characterization methods confirmed the suggested reaction route and the synthesized monomer. A low shrinkage-strain of about 4% was obtained for the new monomer. The results showed that the shrinkage-strain-rate of the monomer followed the autocatalytic model of Kamal and Sourour [Kamal MR, Sourour S. Kinetic and thermal characterization of thermoset cure. Polym Eng Sci 1973;13(1):59-64], which is used to describe the reaction kinetics of thermoset resins. The model parameters were calculated by linearization of the equation. The model prediction was in a good agreement with the experimental data. The properties of the new monomer compare favorably with properties of the commercially available resins.

  13. Improved nine-node shell element MITC9i with reduced distortion sensitivity

    NASA Astrophysics Data System (ADS)

    Wisniewski, K.; Turska, E.

    2017-11-01

    The 9-node quadrilateral shell element MITC9i is developed for the Reissner-Mindlin shell kinematics, the extended potential energy and Green strain. The following features of its formulation ensure an improved behavior: 1. The MITC technique is used to avoid locking, and we propose improved transformations for bending and transverse shear strains, which render that all patch tests are passed for the regular mesh, i.e. with straight element sides and middle positions of midside nodes and a central node. 2. To reduce shape distortion effects, the so-called corrected shape functions of Celia and Gray (Int J Numer Meth Eng 20:1447-1459, 1984) are extended to shells and used instead of the standard ones. In effect, all patch tests are passed additionally for shifts of the midside nodes along straight element sides and for arbitrary shifts of the central node. 3. Several extensions of the corrected shape functions are proposed to enable computations of non-flat shells. In particular, a criterion is put forward to determine the shift parameters associated with the central node for non-flat elements. Additionally, the method is presented to construct a parabolic side for a shifted midside node, which improves accuracy for symmetric curved edges. Drilling rotations are included by using the drilling Rotation Constraint equation, in a way consistent with the additive/multiplicative rotation update scheme for large rotations. We show that the corrected shape functions reduce the sensitivity of the solution to the regularization parameter γ of the penalty method for this constraint. The MITC9i shell element is subjected to a range of linear and non-linear tests to show passing the patch tests, the absence of locking, very good accuracy and insensitivity to node shifts. It favorably compares to several other tested 9-node elements.

  14. Genetics Home Reference: Cowden syndrome

    MedlinePlus

    ... MS, Eng C. A clinical scoring system for selection of patients for PTEN mutation testing is proposed ... should consult with a qualified healthcare professional . About Selection Criteria for Links Data Files & API Site Map ...

  15. Free-standing oxide superconducting articles

    DOEpatents

    Wu, Xin D.; Muenchausen, Ross E.

    1993-01-01

    A substrate-free, free-standing epitaxially oriented superconductive film including a layer of a template material and a layer of a ceramic superconducting material is provided together with a method of making such a substrate-free ceramic superconductive film by coating an etchable material with a template layer, coating the template layer with a layer of a ceramic superconductive material, coating the layer of ceramic superconductive material with a protective material, removing the etchable material by an appropriate means so that the etchable material is separated from a composite structure including the template lay This invention is the result of a contract with the Department of Energy (Contract No. W-7405-ENG-36).

  16. 3. "TEST STAND NO. 13, EXCAVATION PLAN & SECTIONS." Specifications ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. "TEST STAND NO. 1-3, EXCAVATION PLAN & SECTIONS." Specifications No. ENG 04-353-50-10; Drawing No. 60-0906; no sheet number within title block; D.O. SERIES 1109/10. Stamped: AS BUILT. No revisions or revision dates. Last work date on this drawing "Checked by EAG, 1/31/49." Though this drawing is specific to Test Stand 1-3, it also illustrates the general methods used for excavation design and retaining wall construction at Test Stand 1-5. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-3, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  17. [Demography perspectives and forecasts of the demand for electricity].

    PubMed

    Roy, L; Guimond, E

    1995-01-01

    "Demographic perspectives form an integral part in the development of electric load forecasts. These forecasts in turn are used to justify the addition and repair of generating facilities that will supply power in the coming decades. The goal of this article is to present how demographic perspectives are incorporated into the electric load forecasting in Quebec. The first part presents the methods, hypotheses and results of population and household projections used by Hydro-Quebec in updating its latest development plan. The second section demonstrates applications of such demographic projections for forecasting the electric load, with a focus on the residential sector." (SUMMARY IN ENG AND SPA) excerpt

  18. 46 CFR 160.076-5 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Definitions. As used in this part: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop...

  19. 46 CFR 164.120-3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop 7509, 2703 Martin...: SPECIFICATIONS AND APPROVAL MATERIALS Fire Retardant Resins for Lifeboats and Rescue Boats § 164.120-3...

  20. 46 CFR 160.076-5 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Definitions. As used in this part: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division, Life Saving and Fire Safety Division: Commandant (CG-ENG-4), U.S. Coast Guard Headquarters, 2100...

  1. 46 CFR 160.076-5 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Definitions. As used in this part: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop...

  2. 46 CFR 164.120-3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop 7509, 2703 Martin...: SPECIFICATIONS AND APPROVAL MATERIALS Fire Retardant Resins for Lifeboats and Rescue Boats § 164.120-3...

  3. 46 CFR 169.115 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... text of certain industrial standards and specifications are referred to as the governing requirements... 20408 and at the U.S. Coast Guard, Office of Design and Engineering Standards, (CG-ENG), 2100 2nd St...

  4. A review of the PERSIANN family global satellite precipitation data products

    NASA Astrophysics Data System (ADS)

    Nguyen, P.; Ombadi, M.; Ashouri, H.; Thorstensen, A.; Hsu, K. L.; Braithwaite, D.; Sorooshian, S.; William, L.

    2017-12-01

    Precipitation is an integral part of the hydrologic cycle and plays an important role in the water and energy balance of the Earth. Careful and consistent observation of precipitation is important for several reasons. Over the last two decades, the PERSIANN system of precipitation products have been developed at the Center for Hydrometeorology and Remote Sensing (CHRS) at the University of California, Irvine in collaboration with NASA, NOAA and the UNESCO G-WADI program. The PERSIANN family includes three main satellite-based precipitation estimation products namely PERSIANN, PERSIANN-CCS, and PERSIANN-CDR. They are accessible through several web-based interfaces maintained by CHRS to serve the needs of researchers, professionals and general public. These interfaces are CHRS iRain, Data Portal and RainSphere, which can be accessed at http://irain.eng.uci.edu, http://chrsdata.eng.uci.edu, and http://rainsphere.eng.uci.edu respectively and can be used for visualization, analysis or download of the data. The main objective of this presentation is to provide a concise and clear summary of the similarities and differences between the three products in terms of attributes and algorithm structure. Moreover, the presentation aims to provide an evaluation of the performance of the products over the Contiguous United States (CONUS) using Climate Prediction Center (CPC) precipitation dataset as a baseline of comparison. Also, an assessment of the behavior of PERSIANN family products over the globe (60°S - 60°N) is performed.

  5. Mechanisms of Morphology Development and Control in Polymer- Polymer Blends

    NASA Astrophysics Data System (ADS)

    Macosko, Christopher W.

    1998-03-01

    Polymer-polymer blends continue to be the most important method for achieving optimization of properties in plastics products. Over 30 percent of all plastics are blends. While miscible blends generally give average properties between the components, immiscible blends offer synergistic possibilities such as high modulus with high toughness; high flow with high impact strength or diffusion barriers with good mechanical properties and low cost. The key to performance of these immiscible blends is their morphology. There are several important types of morphology which can lead to valuable property improvement: emulsion - small polymer spheres well dispersed in a polymer matrix. double emulsion - spheres inside spheres which are dispersed in another matrix. microlayer - thin, parallel layers of one polymer in a matrix. cocontinuous - two (or more) continuous, interpenetrating polymer phases. To be economical it is desirable to create these morphologies via melt mixing of powder or pellets in conventional compounding equipment. The melting stage during compounding is very important for morphology development. This presentation will demonstrate the role of melting or softening of each phase as well as their viscosity, elasticity and interfacial tension in morphology development. Interfacial modification with premade block copolymers or reactively formed copolymers can greatly alter morphology formation and stability. Experimental results will be presented which quantify the role of these additives. References to recent work in this area by our group are listed below: DeBrule, M. B., L. Levitt and C.W. Macosko, "The Rheology and Morphology of Layered Polymer Melts in Shear," Soc. Plastics Eng. Tech Papers (ANTEC), 84-89 (1996). Guegan, P., C. W. Macosko, T. Ishizone, A. Hirao and S. Nakahama, "Kinetics of Chain Coupling at Melt Interfaces, Macromol. 27, 4993-4997 (1994). Lee, M. S., T.P. Lodge, and C. W. Macosko, "Can Random Copolymers Serve as Effective Polymeric Compatibilizers?" accepted for publication by Journal of Polymer Science, Polymer Physics Edition, 1997. Levitt, L. and C. W. Macosko, "Extensional Rheometry of Polymer Multilayers: A Sensitive Probe of Interfaces," J. Rheol, 41, 3, 671-685, (1997). Levitt, L., C.W. Macosko and S.D. Pearson, "Influence of Normal Stress Difference on Polymer Drop Deformation," Polym. Eng. Sci., 36, Part 12, 1647-1655 (1996). Nakayama, A., T. Inoue, A. Hirao, P. Guegan, A. Khandpur, and C. W. Macosko, "Compatibilization of Blends: Effect of Reaction Rate," PPS Proceedings, Sorrento, May 1996. Levitt, L., "Microlayer Morphology Via Polymer Melt Processing, Ph.D. Thesis, Department of Chemical Engineering & Materials Science, University of Minnesota, 1997. Orr, C. A., A. Adedeji, A. Hirao, F. S. Bates, and C. W. Macosko, "Flow-Induced Reactive Self-Assembly", Macromolecules, 30, 4, 1243-1246, (1997). Orr, C. A., "Reactive Compatibilization of Polymer Blends," Ph.D. Thesis, Department of Chemical Engineering & Materials Science, University of Minnesota, 1997. Scott, C. E., and C. W. Macosko, "Morphology Development During the Initial Stages of Polymer-Polymer Blending," Polymer, 36, 461-470 (1995). Scott, C. E. and C. W. Macosko, "Model Experiments Concerning Morphology Development During the Initial Stages of Polymer Blending," Polymer Bulletin 26, 341- 348 (1991). Sundararaj, U., C. K. Shih, and C. W. Macosko, "Evidence For Inversion of Phase Continuity During Morphology Development in Polymer Blending," Polymer Eng. and Sci., 36, 1769-1781 (1996). Sundararaj, U., and C. W. Macosko, "Drop Breakup and Coalescence in Polymer Blends: The Effects of Concentration and Compatibilization, Macromolecules, 28, 2647-2657 (1995). Sundararaj, U., Y. Dori and C. W. Macosko, "Sheet Formation in Immiscible Polymer Blends: Model Experiments on Initial Blend Morphology," Polymer, 36, 1957-1968 (1995). Sundararaj, U., C. W. Macosko, A. Nakayama, and T. Inoue, "Milligrams to Kilograms: An Evaluation of Mixers for Reactive Polymer Blending," Polym. Eng. Sci. 35, 100-114 (1995). Sundararaj, U, R. J. Rolando, H. T. Chan and C. W. Macosko, "Morphology Development in Polymer Blends," Polymer Eng. Sci. 32, 1814-1823 (1992). Utracki, L., Polymer Alloys and Blends; Hanser: New York, 1989.

  6. Inference of missing data and chemical model parameters using experimental statistics

    NASA Astrophysics Data System (ADS)

    Casey, Tiernan; Najm, Habib

    2017-11-01

    A method for determining the joint parameter density of Arrhenius rate expressions through the inference of missing experimental data is presented. This approach proposes noisy hypothetical data sets from target experiments and accepts those which agree with the reported statistics, in the form of nominal parameter values and their associated uncertainties. The data exploration procedure is formalized using Bayesian inference, employing maximum entropy and approximate Bayesian computation methods to arrive at a joint density on data and parameters. The method is demonstrated in the context of reactions in the H2-O2 system for predictive modeling of combustion systems of interest. Work supported by the US DOE BES CSGB. Sandia National Labs is a multimission lab managed and operated by Nat. Technology and Eng'g Solutions of Sandia, LLC., a wholly owned subsidiary of Honeywell Intl, for the US DOE NCSA under contract DE-NA-0003525.

  7. Genetics Home Reference: Bannayan-Riley-Ruvalcaba syndrome

    MedlinePlus

    ... VP, Eng C, Hudgins L. The spectrum and evolution of phenotypic findings in PTEN mutation positive cases ... Accessibility FOIA Viewers & Players U.S. Department of Health & Human Services National Institutes of Health National Library of ...

  8. 46 CFR 160.170-3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety... Safety of Life at Sea, 1974, as amended. [USCG-2010-0048, 76 FR 63007, Oct. 11, 2011, as amended by USCG...

  9. 46 CFR 160.133-3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety... Convention for the Safety of Life at Sea, 1974, as amended. [USCG-2010-0048, 76 FR 62983, Oct. 11, 2011, as...

  10. 46 CFR 160.170-3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety... Safety of Life at Sea, 1974, as amended. [USCG-2010-0048, 76 FR 63007, Oct. 11, 2011, as amended by USCG...

  11. INDOT Technical Training Plan : Appendix B

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  12. INDOT Technical Training Plan : Appendix M

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  13. INDOT Technical Training Plan : Appendix P

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  14. 32 CFR 644.70 - Closing of cases.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... made before satisfaction of all tax liens. The tax receipt should be forwarded to HQDA (DAEN-REP-S... Department of the Treasury Form and completed ENG Forms 1569 and 1571. (x) Certified copy of any waiver...

  15. 32 CFR 644.70 - Closing of cases.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... made before satisfaction of all tax liens. The tax receipt should be forwarded to HQDA (DAEN-REP-S... Department of the Treasury Form and completed ENG Forms 1569 and 1571. (x) Certified copy of any waiver...

  16. 32 CFR 644.70 - Closing of cases.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... made before satisfaction of all tax liens. The tax receipt should be forwarded to HQDA (DAEN-REP-S... Department of the Treasury Form and completed ENG Forms 1569 and 1571. (x) Certified copy of any waiver...

  17. 32 CFR 644.70 - Closing of cases.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... made before satisfaction of all tax liens. The tax receipt should be forwarded to HQDA (DAEN-REP-S... Department of the Treasury Form and completed ENG Forms 1569 and 1571. (x) Certified copy of any waiver...

  18. INDOT Technical Training Plan : Appendix F

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  19. INDOT Technical Training Plan : Appendix H

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  20. INDOT Technical Training Plan : Appendix E

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  1. INDOT Technical Training Plan : Appendix O

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  2. INDOT Technical Training Plan : Appendix J

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  3. INDOT Technical Training Plan : Appendix L

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  4. INDOT Technical Training Plan : Appendix A

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  5. INDOT Technical Training Plan : Appendix D

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  6. Electric Vehicles : Impacts on Transportation Revenue

    DOT National Transportation Integrated Search

    2017-06-07

    The maintenance of transportation infrastructures has traditionally been funded from federal and state taxes collected by the state from fossil fuel distributors, included into fuel price at the pump and ultimately paid by all internal combustion eng...

  7. INDOT Technical Training Plan : Appendix K

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  8. INDOT Technical Training Plan : Appendix G

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  9. INDOT Technical Training Plan : Appendix I

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  10. INDOT Technical Training Plan : Appendix N

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  11. INDOT Technical Training Plan : Appendix C

    DOT National Transportation Integrated Search

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  12. Primary FRCS Eng

    PubMed Central

    Tresidder, Gerald

    1974-01-01

    The importance of establishing that a candidate can communicate in English—spoken and written—is stressed. The value of written answers is that they show a candidate's understanding of the subject and his ability to express himself lucidly and logically. PMID:4417892

  13. [Not Available].

    PubMed

    Gourevitch, Danielle

    2016-01-01

    After a paper by Jacques Chevallier (Histoire des sciences médicales, XLIX, 2015, 179-188), the author presents two unpublished letters from Engène Brieux, a popular write, and amateur of cruises, to Dr. Édouard Toulouse, a famous psychiatrist.

  14. An Integrated Procedure for the Structural Design of a Composite Rotor-Hydrofoil of a Water Current Turbine (WCT)

    NASA Astrophysics Data System (ADS)

    Oller Aramayo, S. A.; Nallim, L. G.; Oller, S.

    2013-12-01

    This paper shows an integrated structural design optimization of a composite rotor-hydrofoil of a water current turbine by means the finite elements method (FEM), using a Serial/Parallel mixing theory (Rastellini et al. Comput. Struct. 86:879-896, 2008, Martinez et al., 2007, Martinez and Oller Arch. Comput. Methods. 16(4):357-397, 2009, Martinez et al. Compos. Part B Eng. 42(2011):134-144, 2010) coupled with a fluid-dynamic formulation and multi-objective optimization algorithm (Gen and Cheng 1997, Lee et al. Compos. Struct. 99:181-192, 2013, Lee et al. Compos. Struct. 94(3):1087-1096, 2012). The composite hydrofoil of the turbine rotor has been design using a reinforced laminate composites, taking into account the optimization of the carbon fiber orientation to obtain the maximum strength and lower rotational-inertia. Also, these results have been compared with a steel hydrofoil remarking the different performance on both structures. The mechanical and geometrical parameters involved in the design of this fiber-reinforced composite material are the fiber orientation, number of layers, stacking sequence and laminate thickness. Water pressure in the rotor of the turbine is obtained from a coupled fluid-dynamic simulation (CFD), whose detail can be found in the reference Oller et al. (2012). The main purpose of this paper is to achieve a very low inertia rotor minimizing the start-stop effect, because it is applied in axial water flow turbine currently in design by the authors, in which is important to take the maximum advantage of the kinetic energy. The FEM simulation codes are engineered by CIMNE (International Center for Numerical Method in Engineering, Barcelona, Spain), COMPack for the solids problem application, KRATOS for fluid dynamic application and RMOP for the structural optimization. To validate the procedure here presented, many turbine rotors made of composite materials are analyzed and three of them are compared with the steel one.

  15. Census of U.S. Civil Aircraft, Calendar Year 1985.

    DTIC Science & Technology

    1985-12-31

    LIMITED BN-2B-2 10 5’ 2 0 1 BN-26-21 10 51 2 0 1 1 F/W MULTI REC. ENG 51 0 2 2 TOTAL 0 2 2 . PINE AIR % SUPER V 4 51 2 0 1 F/W MULTI REC. ENG 51 0 1 1... Plymouth 32 12 15 2 2 1Pocahontas 22 7 13 1 1Polk 405 104 180 36 17 23 1 8 3 2 1 30 *Pottawatta 68 12 39 7 2 6 3 0 . Powes"In 21 7 10 2 2 Ringgold 3 2 1...2 Ballard 3 2 Barren 22 4 14 1 3 Bath 2 1 Bell 12 1 8 2 Boone 17 4 9 1 1 2 Bourbon 5 1 3 Boyd 37 8 14 6 2 2 2 Boyle 12 4 Bracken 3 2 1 Breatnitt 9

  16. Effective Thermal Conductivity of Graphite Materials with Cracks

    NASA Astrophysics Data System (ADS)

    Pestchaanyi, S. E.; Landman, I. S.

    The dependence of effective thermal diffusivity on temperature caused by volumetric cracks is modelled for macroscopic graphite samples using the three-dimensional thermomechanics code Pegasus-3D. At high off-normal heat loads typical of the divertor armour, thermostress due to the anisotropy of graphite grains is much larger than that due to the temperature gradient. Numerical simulation demonstrated that the volumetric crack density both in fine grain graphites and in the CFC matrix depends mainly on the local sample temperature, not on the temperature gradient. This allows to define an effective thermal diffusivity for graphite with cracks. The results obtained are used to explain intense cracking and particle release from carbon based materials under electron beam heat load. Decrease of graphite thermal diffusivity with increase of the crack density explains particle release mechanism in the experiments with CFC where a clear energy threshold for the onset of particle release has been observed in J. Linke et al. Fusion Eng. Design, in press, Bazyler et al., these proceedings. Surface temperature measurement is necessary to calibrate the Pegasus-3D code for simulation of ITER divertor armour brittle destruction.

  17. Disruption forces on the tokamak wall with and without poloidal currents

    NASA Astrophysics Data System (ADS)

    Pustovitov, V. D.

    2017-05-01

    The contributions into the disruption radial force on the tokamak vacuum vessel wall are calculated and analyzed. One is due to the induced toroidal current in the wall, and another is due to the poloidal current. The latter is not accounted for in the models that represent the wall as a set of isolated toroidal filaments. It is shown that such modeling must lead to significant errors in the evaluation of the force during either thermal or current quench. The analytical derivations are performed here for an arbitrary tokamak configuration with final estimates for a circular large-aspect-ratio plasma and a coaxial wall reacting on perturbations as a perfect conductor. The results are compared with those recently obtained numerically by the codes DINA, MAXFEA and CarMa0NL. The discrepancies between the DINA simulations (Khayrutdinov et al 2016 Plasma Phys. Control. Fusion 58 115012) and earlier analytical predictions are explained. The recent conclusion (Villone et al 2015 Fusion Eng. Des. 93 57) on the role of the disruption-induced poloidal current in the wall is confirmed and extended to a wider area.

  18. A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary.

    PubMed

    Lun, K; Brand, M

    1998-08-01

    Generation of cell diversity in the vertebrate central nervous system starts during gastrulation stages in the ectodermal germ layer and involves specialized cell groups, such as the organizer located at the midbrain-hindbrain boundary (MHB). Mutations in the zebrafish no isthmus (noi) gene alter development of the MHB, and affect the pax2.1 gene (formerly pax(zf-b)). Analysis of the structure of pax2.1 reveals at least 12 normal splice variants. The noi alleles can be arranged, by molecular and phenotypic criteria, into a series of five alleles of differing strength, ranging from a null allele to weak alleles. In keeping with a role in development of the MHB organizer, gene expression is already affected in the MHB primordium of the gastrula neural ectoderm in noi mutants. eng3 activation is completely and eng2 activation is strongly dependent on noi function. In contrast, onset of wnt1, fgf8 and her5 expression occurs normally in the null mutants, but is eliminated later on. Our observations suggest that three signaling pathways, involving pax2.1, wnt1 and fgf8, are activated independently in early anterior-posterior patterning of this area. In addition, analysis of the allelic series unexpectedly suggests that noi activity is also required during dorsal-ventral patterning of the MHB in somitogenesis stages, and possibly in a later eng expression phase. We propose that noi/pax2.1 participates in sequential signaling processes as a key integrator of midbrain-hindbrain boundary development.

  19. DHPLC-based mutation analysis of ENG and ALK-1 genes in HHT Italian population.

    PubMed

    Lenato, Gennaro M; Lastella, Patrizia; Di Giacomo, Marilena C; Resta, Nicoletta; Suppressa, Patrizia; Pasculli, Giovanna; Sabbà, Carlo; Guanti, Ginevra

    2006-02-01

    Hereditary haemorrhagic telangiectasia (HHT or Rendu-Osler-Weber syndrome) is an autosomal dominant disorder characterized by localized angiodysplasia due to mutations in endoglin, ALK-1 gene, and a still unidentified locus. The lack of highly recurrent mutations, locus heterogeneity, and the presence of mutations in almost all coding exons of the two genes makes the screening for mutations time-consuming and costly. In the present study, we developed a DHPLC-based protocol for mutation detection in ALK1 and ENG genes through retrospective analysis of known sequence variants, 20 causative mutations and 11 polymorphisms, and a prospective analysis on 47 probands with unknown mutation. Overall DHPLC analysis identified the causative mutation in 61 out 66 DNA samples (92.4%). We found 31 different mutations in the ALK1 gene, of which 15 are novel, and 20, of which 12 are novel, in the ENG gene, thus providing for the first time the mutational spectrum in a cohort of Italian HHT patients. In addition, we characterized the splicing pattern of ALK1 gene in lymphoblastoid cells, both in normal controls and in two individuals carrying a mutation in the non-invariant -3 position of the acceptor splice site upstream exon 6 (c.626-3C>G). Functional essay demonstrated the existence, also in normal individuals, of a small proportion of ALK1 alternative splicing, due to exon 5 skipping, and the presence of further aberrant splicing isoforms in the individuals carrying the c.626-3C>G mutation. 2006 Wiley-Liss, Inc.

  20. An ERP study of second language learning after childhood: effects of proficiency.

    PubMed

    Ojima, Shiro; Nakata, Hiroki; Kakigi, Ryusuke

    2005-08-01

    Whether there is an absolute critical period for acquiring language is a matter of continuous debate. One approach to address this issue is to compare the processes of second language (L2) learning after childhood and those of first language (L1) learning during childhood. To study the cortical process of postchildhood L2 learning, we compared event-related brain potentials recorded from two groups of adult Japanese speakers who attained either high or intermediate proficiency in English after childhood (J-High and J-Low), and adult native English speakers (ENG). Semantic anomalies embedded in English sentences evoked a clear N400 component in all three groups, with only the time course of the brain activation varying among the groups. Syntactic violations elicited a left-lateralized negativity similar to the left anterior negativity in ENG and J-High, but not in J-Low. In ENG, a P600 component was additionally found. These results suggest that semantic processing is robust from early on in L2 learning, whereas the development of syntactic processing is more dependent on proficiency as evidenced by the lack of the left-lateralized negativity in J-Low. Because early maturation and stability of semantic processing as opposed to syntactic processing are also a feature of L1 processing, postchildhood L2 learning may be governed by the same brain properties as those which govern childhood L1 learning. We argue that these processes are qualitatively similar in many respects, with only restricted domains of language processing being subject to absolute critical period effects.

  1. Association between an endoglin gene polymorphism and systemic sclerosis-related pulmonary arterial hypertension.

    PubMed

    Wipff, J; Kahan, A; Hachulla, E; Sibilia, J; Cabane, J; Meyer, O; Mouthon, L; Guillevin, L; Junien, C; Boileau, C; Allanore, Y

    2007-04-01

    Systemic sclerosis (SSc) is a connective tissue disorder characterized by early generalized microangiopathy with disturbed angiogenesis. Endoglin gene (ENG) encodes a transmembrane glycoprotein which acts as an accessory receptor for the transforming growth factor-beta (TGF-beta) superfamily, and is crucial for maintaining vascular integrity. A 6-base insertion in intron 7 (6bINS) of ENG has been reported to be associated with microvascular disturbance. Our objective was to investigate the relationship between 6bINS and the vascular complication pulmonary arterial hypertension (PAH) in SSc in a French Caucasian population. Two hundred eighty SSc cases containing 29/280 having PAH diagnosed by catheterism were compared with 140 patients with osteoarthritis. Genotyping was performed by polymerase-chain-reaction-based fluorescence and direct sequencing of genomic DNA. The polymorphism was in Hardy-Weinberg equilibrium. We observed a significant lower frequency of 6bINS allele in SSc patients with associated PAH compared with controls [10.3 vs 23.9%, P = 0.01; odds ratio (OR) 0.37, 95% confidence interval (CI) 0.15-0.89], and a trend in comparison with SSc patients without PAH (10.3 vs 20.3%, P = 0.05; OR: 0.45, 95% CI: 0.19-1.08). Genotypes carrying allele 6bINS were also less frequent in SSc patients with PAH than in controls (20.7 vs 42.9%, P = 0.02). Thus the frequency of 6bINS differs between SSc patients with or without PAH, suggesting the implication of ENG in this devastating vascular complication of SSc.

  2. [Organization of domestic groups in the hinterlands of Lisbon: a study of different conducts].

    PubMed

    Da Silva, A F

    1993-01-01

    The author analyzes "methods of domestic organization in a hinterland area in Lisbon, [Portugal, particularly] in Oeiras, between 1730 and 1810. Results show the existence of two systems of domestic group organization: farmers and workers. The [farmers] set up a succession strategy associated with the defence of familiar heritage.... Workers consider that their organization strategy is based on both setting up new families and giving up any system of generation succession by which the principal aim is the perpetuation of the familiar heritage.... Both systems are the results of different economic and hierarchical positions in the Oeiras society." (SUMMARY IN ENG AND FRE AND SPA) excerpt

  3. Improving spatial resolution in skin-contact thermography: comparison between a spline based and linear interpolation.

    PubMed

    Giansanti, Daniele

    2008-07-01

    A wearable device for skin-contact thermography [Giansanti D, Maccioni G. Development and testing of a wearable integrated thermometer sensor for skin contact thermography. Med Eng Phys 2006 [ahead of print

  4. MISR Level 1A Products

    Atmospheric Science Data Center

    2013-04-01

    ... MISR Level 1A Products Level 1A Engineering Data File Type 1 and Level 1A Navigation Data Processing ... Product Specification Rev K  (PDF). Transparent software rebuild with Irix 6.5.2 OS. F01_0007 (FM_ENG), ...

  5. 46 CFR 147.7 - Incorporation by reference.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES HAZARDOUS SHIPS' STORES... approved material is available for inspection at Coast Guard Headquarters. Contact Commandant (CG-ENG... is also available for inspection at the National Archives and Records Administration (NARA). For...

  6. Vitamin D Supplementation Decreases TGF-β1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial.

    PubMed

    Irani, Mohamad; Seifer, David B; Grazi, Richard V; Julka, Nitasha; Bhatt, Devika; Kalgi, Bharati; Irani, Sara; Tal, Oded; Lambert-Messerlian, Geralyn; Tal, Reshef

    2015-11-01

    There is an abnormal increase in TGF-β1 bioavailability in women with polycystic ovary syndrome (PCOS), which might play a role in the pathophysiology of this syndrome. Vitamin D (VD) supplementation improves various clinical manifestations of PCOS and decreases TGF-β1 levels in several diseases including myelofibrosis. The objective of the study was to determine the effect of VD supplementation on TGF-β1 bioavailability in VD-deficient women with PCOS and assess whether changes in TGF-β1/soluble endoglin (sENG) levels correlate with an improvement in PCOS clinical manifestations. This was a prospective, randomized, placebo-controlled trial. The study was conducted at an academic-affiliated medical center. Sixty-eight VD-deficient women with PCOS who were not pregnant or taking any exogenous hormones were recruited between October 2013 and January 2015. Forty-five women received 50 000 IU of oral vitamin D3 and 23 women received oral placebo once weekly for 8 weeks. Serum TGF-β1, sENG, lipid profile, testosterone, dehydroepiandrosterone sulfate, and insulin resistance were measured. The clinical parameters were evaluated before and 2 months after treatment. The VD level significantly increased and normalized after VD supplementation (16.3 ± 0.9 [SEM] to 43.2 ± 2.4 ng/mL; P < .01), whereas it did not significantly change after placebo. After the VD supplementation, there was a significant decrease in the following: the interval between menstrual periods (80 ± 9 to 60 ± 6 d; P = .04), Ferriman-Gallwey score (9.8 ± 1.5 to 8.1 ± 1.5; P < .01), triglycerides (138 ± 22 to 117 ± 20 mg/dL; P = .03), and TGF-β1 to sENG ratio (6.7 ± 0.4 to 5.9 ± 0.4; P = .04). In addition, the ΔTGF-β1 to sENG ratio was positively correlated with Δtriglycerides (r = 0.59; P = .03). VD supplementation in VD-deficient women with PCOS significantly decreases the bioavailability of TGF-β1, which correlates with an improvement in some abnormal clinical parameters associated with PCOS. This is a novel mechanism that could explain the beneficial effects of VD supplementation in women with PCOS. These findings may support new treatment modalities for PCOS, such as the development of anti-TGF-β drugs.

  7. Percolation and permeability of heterogeneous fracture networks

    NASA Astrophysics Data System (ADS)

    Adler, Pierre; Mourzenko, Valeri; Thovert, Jean-François

    2013-04-01

    Natural fracture fields are almost necessarily heterogeneous with a fracture density varying with space. Two classes of variations are quite frequent. In the first one, the fracture density is decreasing from a given surface; the fracture density is usually (but not always see [1]) an exponential function of depth as it has been shown by many measurements. Another important example of such an exponential decrease consists of the Excavated Damaged Zone (EDZ) which is created by the excavation process of a gallery [2,3]. In the second one, the fracture density undergoes some local random variations around an average value. This presentation is mostly focused on the first class and numerical samples are generated with an exponentially decreasing density from a given plane surface. Their percolation status and hydraulic transmissivity can be calculated by the numerical codes which are detailed in [4]. Percolation is determined by a pseudo diffusion algorithm. Flow determination necessitates the meshing of the fracture networks and the discretisation of the Darcy equation by a finite volume technique; the resulting linear system is solved by a conjugate gradient algorithm. Only the flow properties of the EDZ along the directions which are parallel to the wall are of interest when a pressure gradient parallel to the wall is applied. The transmissivity T which relates the total flow rate per unit width Q along the wall through the whole fractured medium to the pressure gradient grad p, is defined by Q = - T grad p/mu where mu is the fluid viscosity. The percolation status and hydraulic transmissivity are systematically determined for a wide range of decay lengths and anisotropy parameters. They can be modeled by comparison with anisotropic fracture networks with a constant density. A heuristic power-law model is proposed which accurately describes the results for the percolation threshold over the whole investigated range of heterogeneity and anisotropy. Then, the data for transmissivity are presented. A simple parallel flow model is introduced. The flow properties of the medium vary with the distance z from the wall. However, the macroscopic pressure gradient does not depend on z, and the flow lines are in average parallel to the wall. Hence, the overall transmissivity is tentatively estimated by a parallel flow model, where a layer at depth z behaves as a fractured medium with uniform properties corresponding to the state at this position in the medium. It yields an explicit analytical expression for the transmissivity as a function of the heterogeneity and anisotropy parameters, and it successfully accounts for all the numerical data. Graphical tools are provided from which first estimates can be quickly and easily obtained. A short overview of the second class of heterogeneous media will be given. [1] Barton C.A., Zoback M.D., J. Geophys. Res., 97B, 5181-5200 (1992). [2] Bossart P. et al, Eng. Geol., vol. 66, 19-38 (2002). [3] Thovert J.-F. et al, Eng. Geol., 117, 39-51 (2011). [4] Adler P.M. et al, Fractured porous media, Oxford U. Press, 2012.

  8. Closed-Form Solutions for a Circular Tunnel in Elastic-Brittle-Plastic Ground with the Original and Generalized Hoek-Brown Failure Criteria

    NASA Astrophysics Data System (ADS)

    Chen, Ran; Tonon, Fulvio

    2011-03-01

    The paper presents a closed-form solution for the convergence curve of a circular tunnel in an elasto-brittle-plastic rock mass with both the Hoek-Brown and generalized Hoek-Brown failure criteria, and a linear flow rule, i.e., the ratio between the minor and major plastic strain increments is constant. The improvement over the original solution of Brown et al. (J Geotech Eng ASCE 109(1):15-39, 1983) consists of taking into account the elastic strain variation in the plastic annulus, which was assumed to be fixed in the original solution by Brown et al. The improvement over Carranza-Torres' solution (Int J Rock Mech Min Sci 41(Suppl 1):629-639, 2004) consists of providing a closed-form solution, rather than resorting to numerical integration of an ordinary differential equation. The presented solution, by rigorously following the theory of plasticity, takes into account that the elastic strain components change with radial and circumferential stress changes within the plastic annulus. For the original Hoek-Brown failure criterion, disregarding the elastic strain change leads to underestimate the convergence by up to 55%. For a rock mass failing according to the generalized Hoek-Brown failure criterion, using the original failure criterion leads to a high probability (97%) of underestimating the convergence by up to 100%. As a consequence, the onset or degree of squeezing may be underestimated, and the loading on the support/reinforcement calculated with the convergence/confinement method may be largely underestimated.

  9. 46 CFR 78.01-2 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...), and at the U.S. Coast Guard, Lifesaving and Fire Safety Division (CG-ENG-4), 2100 2nd St., SW., Stop... Kingdom. Resolution A.654(16), Graphical Symbols for Fire Control Plans—78.45-1 [CGD 95-028, 62 FR 51204...

  10. [Female employment and emigration: from the countries of Africa and Asia to Rome].

    PubMed

    Arena, G

    1983-06-01

    Recent trends in female labor migration from third world countries to Rome, Italy, are analyzed. The impact of the demand for various types of labor and of religious background is considered. (summary in ENG, FRE)

  11. 46 CFR 154.520 - Piping calculations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... allowable stress values under § 56.07-10 of this chapter and, if the design temperature is −110 °C (−166 °F) or lower, the stress analysis must be specially approved by the Commandant (CG-ENG) and must include...

  12. 46 CFR 154.520 - Piping calculations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... allowable stress values under § 56.07-10 of this chapter and, if the design temperature is −110 °C (−166 °F) or lower, the stress analysis must be specially approved by the Commandant (CG-ENG) and must include...

  13. JPRS Report Nuclear Developments

    DTIC Science & Technology

    1988-09-02

    cracks in Atucha I were detected during the administration of Eng Alberto Constantini. Last year Constantini resigned as CNEA president due to...days, Finance Minister Mailson da Nobrega, Mines and Energy Minis- ter Aureliano Chaves, and Planning Minister Joao Batista de Abreu should be

  14. EFFECTS OF GAMMA RADIATION ON TWO DECAPOD CRUSTACEANS, PALAEMONETES PUGIO AND UCA PUGNAX

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rees, G.H.

    1962-03-01

    Experiments are described that were undertaken with the objective of determining the lethal dosages of gamma radiation, particularly the doses at which 50% succumb (LD/sub 50/), for 2 decapod crustaceans. (Pub. Health Eng. Abstr.)

  15. 3D Neutronic Analysis in MHD Calculations at ARIES-ST Fusion Reactors Systems

    NASA Astrophysics Data System (ADS)

    Hançerliogulları, Aybaba; Cini, Mesut

    2013-10-01

    In this study, we developed new models for liquid wall (FW) state at ARIES-ST fusion reactor systems. ARIES-ST is a 1,000 MWe fusion reactor system based on a low aspect ratio ST plasma. In this article, we analyzed the characteristic properties of magnetohydrodynamics (MHD) and heat transfer conditions by using Monte-Carlo simulation methods (ARIES Team et al. in Fusion Eng Des 49-50:689-695, 2000; Tillack et al. in Fusion Eng Des 65:215-261, 2003) . In fusion applications, liquid metals are traditionally considered to be the best working fluids. The working liquid must be a lithium-containing medium in order to provide adequate tritium that the plasma is self-sustained and that the fusion is a renewable energy source. As for Flibe free surface flows, the MHD effects caused by interaction with the mean flow is negligible, while a fairly uniform flow of thick can be maintained throughout the reactor based on 3-D MHD calculations. In this study, neutronic parameters, that is to say, energy multiplication factor radiation, heat flux and fissile fuel breeding were researched for fusion reactor with various thorium and uranium molten salts. Sufficient tritium amount is needed for the reactor to work itself. In the tritium breeding ratio (TBR) >1.05 ARIES-ST fusion model TBR is >1.1 so that tritium self-sufficiency is maintained for DT fusion systems (Starke et al. in Fusion Energ Des 84:1794-1798, 2009; Najmabadi et al. in Fusion Energ Des 80:3-23, 2006).

  16. Choosing the best rehabilitation treatment for Bell's palsy.

    PubMed

    Dalla Toffola, E; Tinelli, C; Lozza, A; Bejor, M; Pavese, C; Degli Agosti, I; Petrucci, L

    2012-12-01

    It is useful to perform neurophysiologic electromyography and electroneurography (EMG/ENG) on patients with peripheral facial palsy during the acute phase of paralysis in order to assess the severity of their nerve lesion and thus plan rehabilitation treatment and evaluate its results. To evaluate the motor recovery of patients with Bell's palsy with respect to the severity of their neurological lesion and to compare the results of two different rehabilitation treatments, with electromyographic biofeedback (EMG-BFB) and mirror visual biofeedback (mirror-BFB), in patients with Bell's palsy and neurophysiologic pattern of axonotmesis. Cohort study on retrospective clinical records. 102 patients with Bell's facial palsy were clinically assessed according to the House scale both during the acute phase of paralysis and 12 months after onset. All patients underwent EMG/ENG examination 3-4 weeks after the onset of paralysis; 29 patients had an EMG pattern of neurapraxia and were not given rehabilitation treatment; 73 patients who presented with signs of denervation had an EMG pattern of axonotmesis. The group, which was homogenous in terms of lesion severity, was divided into two parts: 38 patients were treated with electromyographic biofeedback (EMG-BFB) and 35 were treated with mirror visual feedback (mirror-BFB). All 29 patients with neurapraxia made a full spontaneous recovery; Although the 73 patients with axonotmesis received different types of rehabilitation treatment, they obtained similar results regarding quality of recovery, development of synkinesis, rehabilitation timing and resources used. Rehabilitation treatment is not necessary for patients with neurapraxia. The two biofeedback methods used to treat patients with axonotmesis resulted in similar rehabilitation outcomes.

  17. 46 CFR 97.01-2 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., Lifesaving and Fire Safety Division (CG-ENG-4), 2100 2nd St. SW., Stop 7126, Washington, DC 20593-7126, or at... Symbols for Fire Control Plans—97.36-1 [CGD 95-028, 62 FR 51207, Sept. 30, 1997, as amended by USCG 1998...

  18. 77 FR 59768 - Shipping and Transportation; Technical, Organizational, and Conforming Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    .... Abbreviations II. Regulatory History III. Basis and Purpose IV. Background V. Regulatory Analyses A. Regulatory....S.C. United States Code II. Regulatory History We did not publish a notice of proposed rulemaking... its place, the text ``(CG-ENG)''. [[Page 59778

  19. Statistical Software Engineering

    DTIC Science & Technology

    1998-04-13

    multiversion software subject to coincident errors. IEEE Trans. Software Eng. SE-11:1511-1517. Eckhardt, D.E., A.K Caglayan, J.C. Knight, L.D. Lee, D.F...J.C. and N.G. Leveson. 1986. Experimental evaluation of the assumption of independence in multiversion software. IEEE Trans. Software

  20. LADOTD pavement management system (PMS) for project level applications.

    DOT National Transportation Integrated Search

    2011-06-01

    To fully address the research needs described in the problem statement, the primary objective of this project is to develop guidelines that provide information on how network level PMS data can be used at a project level in activities of pavement eng...

  1. Defense and Arms Control Studies Program

    DTIC Science & Technology

    1991-01-01

    States Military Academy, Poli. Sci. Massachusetts Institute of Technol- ogy, Electr. Eng. Craig Wheeler Cynthia Womack University of California-San...of the Assistant Secretary of Defense (Program Analysis and Evaluation), "Total Force Policy" November 6 - M. Gen. Gene A. Deegan , USMC Vice Director

  2. The Proposal Project

    ERIC Educational Resources Information Center

    Pierce, Elizabeth

    2007-01-01

    The proposal project stretches over a significant portion of the semester-long sophomore course Professional Communication (ENG 250) at Monroe Community College. While developing their proposal project, students need to use time management skills to successfully complete a quality project on time. In addition, excellent oral and written…

  3. Ulnar neuropathy and ulnar neuropathy-like symptoms in relation to biomechanical exposures assessed by a job exposure matrix: a triple case-referent study.

    PubMed

    Svendsen, Susanne Wulff; Johnsen, Birger; Fuglsang-Frederiksen, Anders; Frost, Poul

    2012-11-01

    We aimed to evaluate relations between occupational biomechanical exposures and (1) ulnar neuropathy confirmed by electroneurography (ENG) and (2) ulnar neuropathy-like symptoms with normal ENG. In this triple case-referent study, we identified all patients aged 18-65 years, examined with ENG at a neurophysiological department on suspicion of ulnar neuropathy, 2001-2007. We mailed a questionnaire to 546 patients with ulnar neuropathy, 633 patients with ulnar neuropathy-like symptoms and two separate groups of community referents, matched on sex, age and primary care centre (risk set sampling). The two patient groups were also compared to each other directly. We constructed a Job Exposure Matrix to provide estimates of exposure to non-neutral postures, repetitive movements, hand-arm vibrations and forceful work. Conditional and unconditional logistic regressions were used. The proportion who responded was 59%. Ulnar neuropathy was related to forceful work with an exposure-response pattern reaching an OR of 3.85 (95% CI 2.04 to 7.24); non-neutral postures strengthened effects of forceful work. No relation was observed with repetitive movements. Ulnar neuropathy-like symptoms were related to repetitive movements with an OR of 1.89 (95% CI 1.01 to 3.52) in the highest-exposure category (≥2.5 h/day); forceful work was unrelated to the outcome. Ulnar neuropathy and ulnar neuropathy-like symptoms differed with respect to associations with occupational biomechanical exposures. Findings suggested specific effects of forceful work on the ulnar nerve. Thus, results corroborated the importance of an electrophysiological diagnosis when evaluating risk factors for ulnar neuropathy. Preventive effects may be achieved by reducing biomechanical exposures at work.

  4. Correlations between the clinical, histological and neurophysiological examinations in patients before and after parotid gland tumor surgery: verification of facial nerve transmission.

    PubMed

    Wiertel-Krawczuk, Agnieszka; Huber, Juliusz; Wojtysiak, Magdalena; Golusiński, Wojciech; Pieńkowski, Piotr; Golusiński, Paweł

    2015-05-01

    Parotid gland tumor surgery sometimes leads to facial nerve paralysis. Malignant more than benign tumors determine nerve function preoperatively, while postoperative observations based on clinical, histological and neurophysiological studies have not been reported in detail. The aims of this pilot study were evaluation and correlations of histological properties of tumor (its size and location) and clinical and neurophysiological assessment of facial nerve function pre- and post-operatively (1 and 6 months). Comparative studies included 17 patients with benign (n = 13) and malignant (n = 4) tumors. Clinical assessment was based on House-Brackmann scale (H-B), neurophysiological diagnostics included facial electroneurography [ENG, compound muscle action potential (CMAP)], mimetic muscle electromyography (EMG) and blink-reflex examinations (BR). Mainly grade I of H-B was recorded both pre- (n = 13) and post-operatively (n = 12) in patients with small (1.5-2.4 cm) benign tumors located in superficial lobes. Patients with medium size (2.5-3.4 cm) malignant tumors in both lobes were scored at grade I (n = 2) and III (n = 2) pre- and mainly VI (n = 4) post-operatively. CMAP amplitudes after stimulation of mandibular marginal branch were reduced at about 25 % in patients with benign tumors after surgery. In the cases of malignant tumors CMAPs were not recorded following stimulation of any branch. A similar trend was found for BR results. H-B and ENG results revealed positive correlations between the type of tumor and surgery with facial nerve function. Neurophysiological studies detected clinically silent facial nerve neuropathy of mandibular marginal branch in postoperative period. Needle EMG, ENG and BR examinations allow for the evaluation of face muscles reinnervation and facial nerve regeneration.

  5. Angiogenic profile and smoking in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort.

    PubMed

    Jääskeläinen, Tiina; Suomalainen-König, Sanna; Hämäläinen, Esa; Pulkki, Kari; Romppanen, Jarkko; Heinonen, Seppo; Laivuori, Hannele

    2017-11-01

    The biological mechanism by which smoking reduces the risk of pre-eclampsia (PE) is unresolved. We studied serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and their ratio, in addition to soluble endoglin (sEng) in early and late pregnancy to ascertain whether these factors are altered in women who smoke. First trimester serum samples were available from 217 women who later developed PE and 238 women who did not develop PE. Second/third trimester serum samples were available from 174 PE and 54 non-PE women. PE women who smoked during pregnancy had elevated first trimester concentrations of serum PlGF [geometric mean (95% CI): 39.8 (32.6-48.5) pg/ml, p = .001] and reduced sEng concentration [5.0 (4.6-5.6) ng/ml, p = .047] compared to PE non-smokers [30.0 (28.1-32.1) pg/ml and 6.1 (5.9-6.4) ng/ml, respectively]. Non-smoking women in the PE group had the highest sFlt-1/PlGF ratio in early and late pregnancy. The protective effect of smoking in reducing the risk of PE may be due to the early pregnancy change towards pro-angiogenic marker profile. Also, in late pregnancy, smoking exerted effect in sFlt-1/PlGF ratio in PE pregnancies, and may complicate its use as a prognostic and diagnostic marker. Key messages Smoking appears to have angiogenic effects in early pregnancy with reduced sEng concentrations and elevated PlGF concentrations in both normal and PE pregnancies. Throughout pregnancy, smoking exerted effect in PlGF concentration and sFlt-1/PlGF ratio in PE pregnancies, and thus may complicate its use as a prognostic and diagnostic marker.

  6. A comparison of the quality of care in accident and emergency departments in England and the Netherlands as experienced by patients.

    PubMed

    Bos, Nanne; Seccombe, Ian J; Sturms, Leontien M; Stellato, Rebecca; Schrijvers, Augustinus J P; van Stel, Henk F

    2016-06-01

    Measuring patients' experiences to determine health-care performance and quality of care from their perspective can provide valuable evidence for international improvements in the quality of care. We compare patients' experiences in Accident & Emergency departments (A&E) in England and the Netherlands and discuss the usefulness of this comparison. A cross-sectional survey was conducted among patients attending A&Es aged 18 years and older. In England, 134 A&Es were surveyed. In the Netherlands, nine hospitals participated in the study. Main outcome measures were patients' experiences represented by six domain scores aggregated on the country level or on the A&E level. In England, 43 892 completed questionnaires were received (40%). In the Netherlands, 1865 completed questionnaires were received (42%). Three of six domain scores were significantly higher for patients in the Netherlands: 'waiting time' [mean scores of 73.8 (NL) versus 67.2 (ENG)], 'doctors and nurses' [mean scores of 85.7 (NL) versus 80.6 (ENG)] and 'your care and treatment' [mean scores of 82.6 (NL) and 80.2 (ENG)]. The variance among the English A&Es was large. The best and worst practices on five domains were English. The mean quality of care in the A&E appeared to be better in the Netherlands on three domains, but the best practices were English A&Es. The within-country differences between A&Es were much larger than differences between countries. Healthcare performance in the A&E can be compared between countries by surveying patients' experiences, and there seems much to learn across A&Es both within and among countries. © 2014 John Wiley & Sons Ltd.

  7. Mathematical simulation of forced expiration.

    PubMed

    Elad, D; Kamm, R D; Shapiro, A H

    1988-07-01

    Flow limitation during forced expiration is simulated by a mathematical model. This model draws on the pressure-area law obtained in the accompanying paper, and the methods of analysis for one-dimensional flow in collapsible tubes developed by Shapiro (Trans. ASME J. Biomech. Eng. 99: 126-147, 1977). These methods represent an improvement over previous models in that 1) the effects of changing lung volume and of parenchymal-bronchial interdependence are simulated; 2) a more realistic representation of collapsed airways is employed; 3) a solution is obtained mouthward of the flow-limiting site by allowing for a smooth transition from sub- to supercritical flow speeds, then matching mouth pressure by imposing an elastic jump (an abrupt transition from super- to subcritical flow speeds) at the appropriate location; and 4) the effects of levels of effort (or vacuum pressure) in excess of those required to produce incipient flow limitation are examined, including the effects of potential physiological limitation.

  8. Single event mass spectrometry

    DOEpatents

    Conzemius, Robert J.

    1990-01-16

    A means and method for single event time of flight mass spectrometry for analysis of specimen materials. The method of the invention includes pulsing an ion source imposing at least one pulsed ion onto the specimen to produce a corresponding emission of at least one electrically charged particle. The emitted particle is then dissociated into a charged ion component and an uncharged neutral component. The ion and neutral components are then detected. The time of flight of the components are recorded and can be used to analyze the predecessor of the components, and therefore the specimen material. When more than one ion particle is emitted from the specimen per single ion impact, the single event time of flight mass spectrometer described here furnis This invention was made with Government support under Contract No. W-7405-ENG82 awarded by the Department of Energy. The Government has certain rights in the invention.

  9. Tsunami focusing and leading wave height

    NASA Astrophysics Data System (ADS)

    Kanoglu, Utku

    2016-04-01

    Field observations from tsunami events show that sometimes the maximum tsunami amplitude might not occur for the first wave, such as the maximum wave from the 2011 Japan tsunami reaching to Papeete, Tahiti as a fourth wave 72 min later after the first wave. This might mislead local authorities and give a wrong sense of security to the public. Recently, Okal and Synolakis (2016, Geophys. J. Int. 204, 719-735) discussed "the factors contributing to the sequencing of tsunami waves in the far field." They consider two different generation mechanisms through an axial symmetric source -circular plug; one, Le Mehaute and Wang's (1995, World Scientific, 367 pp.) formalism where irritational wave propagation is formulated in the framework of investigating tsunamis generated by underwater explosions and two, Hammack's formulation (1972, Ph.D. Dissertation, Calif. Inst. Tech., 261 pp., Pasadena) which introduces deformation at the ocean bottom and does not represent an immediate deformation of the ocean surface, i.e. time dependent ocean surface deformation. They identify the critical distance for transition from the first wave being largest to the second wave being largest. To verify sequencing for a finite length source, Okal and Synolakis (2016) is then used NOAA's validated and verified real time forecasting numerical model MOST (Titov and Synolakis, 1998, J. Waterw. Port Coast. Ocean Eng., 124, 157-171) through Synolakis et al. (2008, Pure Appl. Geophys. 165, 2197-2228). As a reference, they used the parameters of the 1 April 2014 Iquique, Chile earthquake over real bathymetry, variants of this source (small, big, wide, thin, and long) over a flat bathymetry, and 2010 Chile and 211 Japan tsunamis over both real and flat bathymetries to explore the influence of the fault parameters on sequencing. They identified that sequencing more influenced by the source width rather than the length. We extend Okal and Synolakis (2016)'s analysis to an initial N-wave form (Tadepalli and Synolakis, 1994, Proc. R. Soc. A: Math. Phys. Eng. Sci., 445, 99-112) with a finite crest length, which is most common tsunami initial waveform. We fit earthquake initial waveform calculated through Okada (1985, Bull. Seismol. Soc. Am. 75, 1135-1040) to the N-wave form presented by Tadepalli and Synolakis (1994). First, we investigate focusing phenomena as presented by Kanoglu et al. (2013, Proc. R. Soc. A: Math. Phys. Eng. Sci., 469, 20130015) and compare our results with their non-dispersive and dispersive linear analytical solutions. We confirm focusing phenomena, which amplify the wave height in the leading depression side. We then study sequencing of an N-wave profile with a finite crest length. Our preliminary results show that sequencing is more pronounced on the leading depression side. We perform parametric study to understand sequencing in terms of N-wave, hence earthquake, parameters. We then discuss the results both in terms of tsunami focusing and leading wave amplitude. Acknowledgment: The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 603839 (Project ASTARTE - Assessment, Strategy and Risk Reduction for Tsunamis in Europe).

  10. Experimental demonstration of passive acoustic imaging in the human skull cavity using CT-based aberration corrections

    PubMed Central

    Jones, Ryan M.; O’Reilly, Meaghan A.; Hynynen, Kullervo

    2015-01-01

    Purpose: Experimentally verify a previously described technique for performing passive acoustic imaging through an intact human skull using noninvasive, computed tomography (CT)-based aberration corrections Jones et al. [Phys. Med. Biol. 58, 4981–5005 (2013)]. Methods: A sparse hemispherical receiver array (30 cm diameter) consisting of 128 piezoceramic discs (2.5 mm diameter, 612 kHz center frequency) was used to passively listen through ex vivo human skullcaps (n = 4) to acoustic emissions from a narrow-band fixed source (1 mm diameter, 516 kHz center frequency) and from ultrasound-stimulated (5 cycle bursts, 1 Hz pulse repetition frequency, estimated in situ peak negative pressure 0.11–0.33 MPa, 306 kHz driving frequency) Definity™ microbubbles flowing through a thin-walled tube phantom. Initial in vivo feasibility testing of the method was performed. The performance of the method was assessed through comparisons to images generated without skull corrections, with invasive source-based corrections, and with water-path control images. Results: For source locations at least 25 mm from the inner skull surface, the modified reconstruction algorithm successfully restored a single focus within the skull cavity at a location within 1.25 mm from the true position of the narrow-band source. The results obtained from imaging single bubbles are in good agreement with numerical simulations of point source emitters and the authors’ previous experimental measurements using source-based skull corrections O’Reilly et al. [IEEE Trans. Biomed. Eng. 61, 1285–1294 (2014)]. In a rat model, microbubble activity was mapped through an intact human skull at pressure levels below and above the threshold for focused ultrasound-induced blood–brain barrier opening. During bursts that led to coherent bubble activity, the location of maximum intensity in images generated with CT-based skull corrections was found to deviate by less than 1 mm, on average, from the position obtained using source-based corrections. Conclusions: Taken together, these results demonstrate the feasibility of using the method to guide bubble-mediated ultrasound therapies in the brain. The technique may also have application in ultrasound-based cerebral angiography. PMID:26133635

  11. Runtime Simulation for Post-Disaster Data Fusion Visualization

    DTIC Science & Technology

    2006-10-01

    Center for Multisource Information Fusion ( CMIF ) The State University of New York at Buffalo Buffalo, NY 14260 USA kesh@eng.buffalo.edu ABSTRACT...Fusion ( CMIF ) The State University of New York at Buffalo Buffalo, NY 14260 USA 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING

  12. Applying successfully proven measures in roadway safety to reduce harmful collisions in SC.

    DOT National Transportation Integrated Search

    2017-06-06

    The overall goal of this research was to identify proven successful safety programs used in other states and assess the potential for safety improvement if similar programs were implemented in South Carolina. The research team not only sought out eng...

  13. 46 CFR 59.01-2 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING REPAIRS TO BOILERS... Engineering Standards (CG-ENG), 2100 2nd St., SW., Stop 7126, Washington, DC 20593-7126, and is available from the sources listed below. (b) American Society of Mechanical Engineers (ASME) International, Three...

  14. 46 CFR 59.01-2 - Incorporation by reference.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING REPAIRS TO BOILERS...-ENG), Attn: Office of Design and Engineering Systems, U.S. Coast Guard Stop 7509, 2703 Martin Luther... below. (b) American Society of Mechanical Engineers (ASME) International, Three Park Avenue, New York...

  15. 46 CFR 59.01-2 - Incorporation by reference.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING REPAIRS TO BOILERS...-ENG), Attn: Office of Design and Engineering Systems, U.S. Coast Guard Stop 7509, 2703 Martin Luther... below. (b) American Society of Mechanical Engineers (ASME) International, Three Park Avenue, New York...

  16. Isostaticity in Cosserat Continuum

    DTIC Science & Technology

    2012-01-01

    Geotech . Eng. Div. 106(4), 419–433 (1980) 13. Walker, D.M., Tordesillas, A., Thornton, C., Behringer, R.P., Zhang, J., Peters, J.F.: Percolating contact...thermomicromechanical approach to multiscale continuum modeling of dense granular materials. Acta Geotech . 3, 225–240 (2008) 17. Oda, M., Takemura, T

  17. 46 CFR 160.076-11 - Incorporation by reference.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the public. All approved material is available for inspection at the National Archives and Records Administration (NARA) and at Coast Guard Headquarters. Contact Commandant (CG-ENG-4), Attn: Lifesaving and Fire.../federal_register/code_of_federal_regulations/ibr_locations.html. (b) Underwriters Laboratories (UL...

  18. 46 CFR 160.076-11 - Incorporation by reference.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the public. All approved material is available for inspection at the National Archives and Records Administration (NARA) and at Coast Guard Headquarters. Contact Commandant (CG-ENG-4), Attn: Lifesaving and Fire.../federal_register/code_of_federal_regulations/ibr_locations.html. (b) Underwriters Laboratories (UL...

  19. [Demography of children in the Czech Republic in the 1980s].

    PubMed

    Fialova, L

    1996-01-01

    The author analyzes demographic trends affecting children in the Czech Republic in the 1980s. Aspects considered include parental age, employment status of mothers, divorce and remarriage, marriage patterns and living arrangements of young adults, and births outside marriage. (SUMMARY IN ENG)

  20. High-spin states in the N=50 nucleus ^87Rb

    NASA Astrophysics Data System (ADS)

    Fotiades, N.; Cizewski, J. A.; Krücken, R.; Clark, R. M.; Fallon, P.; Lee, I. Y.; Macchiavelli, A. O.; Becker, J. A.; Bernstein, L. A.; McNabb, D. P.; Younes, W.

    2001-10-01

    High-spin states in ^87Rb have been studied following the fission of two compound nuclei (^199Tl and ^197Pb) formed in different fusion-evaporation reactions. The Gammasphere array at LBNL was used to detect γ-ray coincidences. The level scheme has been extended above the previously known 1578 keV, 9/2^+ isomer by observation of many states up to ~7.2 MeV excitation energy. Coupling of the odd g_9/2 proton to the yrast states in the ^86Kr core accounts for the first excited states observed above the 9/2^+ isomer. The level scheme of ^87Rb is also compared to excitations in ^85Kr and the ^89Y isotone. This work has been supported in part by the U.S. Department of Energy under Contracts No. W-7405-ENG-36 (LANL), FG02-91ER-40609 (Yale), W-7405-ENG-48 (LLNL) and AC03-76SF00098 (LBNL) and by the National Science Foundation (Rutgers).

  1. Electronystagmography and audio potentials in space flight

    NASA Technical Reports Server (NTRS)

    Thornton, William E.; Biggers, W. P.; Pool, Sam L.; Thomas, W. G.; Thagard, Norman E.

    1985-01-01

    Beginning with the fourth flight of the Space Transport System (STS-4), objective measurements of inner ear function were conducted in near-zero G conditions in earth orbit. The problem of space motion sickness (SMS) was approached much like any disequilibrium problem encountered clinically. However, objective testing techniques had built-in limitations superimposed by the strict parameters inherent in each mission. An attempt was made to objectively characterize SMS, and to first ascertain whether the objective measurements indicated that this disorder was of peripheral or central origin. Electronystagmography and auditory brain stem response recordings were the primary investigative tools. One of the authors (W.E.T.) was a mission specialist on board the orbiter Challenger on the eighth shuttle mission (STS-8) and had the opportunity to make direct and personal observations regarding SMS, an opportunity which has added immeasurably to our understanding of this disorder. Except for two abnormal ENG records, which remain to be explained, the remaining ENG records and all the ABR records made in the weightless environment of space were normal.

  2. Experimental investigations of castellated monoblock structures in TEXTOR

    NASA Astrophysics Data System (ADS)

    Litnovsky, A.; Philipps, V.; Wienhold, P.; Sergienko, G.; Emmoth, B.; Rubel, M.; Breuer, U.; Wessel, E.

    2005-03-01

    To insure the thermo-mechanical durability of ITER it is planned to manufacture the castellated armour of the divertor i.e. to split the armour into cells [W. Daener et al., Fusion Eng. Des. 61&62 (2002) 61]. This will cause an increase of the surface area and may lead to carbon deposition and tritium accumulation in the gaps in between cells. To investigate the processes of deposition and fuel accumulation in gaps, a castellated test-limiter was exposed to the SOL plasma of TEXTOR. The geometry of castellation used was the same as proposed for the vertical divertor target in ITER [W. Daener et al., Fusion Eng. Des. 61&62 (2002) 61]. After exposure the limiter was investigated with various surface diagnostic techniques. Deposited layers containing carbon, hydrogen, deuterium and boron were found both on top plasma-facing surfaces and in the gaps. The amount of deuterium in the gaps was at least 30% of that found on the top surfaces.

  3. Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies

    PubMed Central

    Troisi, Rebecca; Braekke, Kristin; Harsem, Nina Kittelsen; Hyer, Marianne; Hoover, Robert N.; Staff, Anne Cathrine

    2008-01-01

    Objective The objective of the study was to determine whether blood pressure increases are associated with maternal angiogenic factors in uncomplicated and preeclamptic pregnancies. Study Design Associations of blood pressure increases from mid- to late pregnancy with maternal serum concentrations of soluble fms-like tyrosine kinase receptor (sFlt1), soluble endoglin (sEng), and placental growth factor (PlGF) at delivery were analyzed in 43 uncomplicated and 44 preeclamptic pregnancies. Results In uncomplicated pregnancies, increases in diastolic and mean arterial pressure were inversely associated with PlGF at delivery and positively associated with sEng and sFlt1/PlGF ratio. There were no significant associations between blood pressure increases and angiogenic factor concentrations in preeclampsia. Conclusion These data suggest that angiogenic factors are involved in blood pressure modulation in normotensive pregnancy and are consistent with the hypothesis that angiogenic balance plays a role in maternal breast cancer risk reduction associated with mid- to late blood pressure increases in uncomplicated pregnancies. PMID:18722574

  4. A Comparison of Neutron-Based Non-Destructive Assessment Methods for Chemical Warfare Materiel and High Explosives

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    E.H. Seabury; D.L. Chichester; C.J. Wharton

    2008-08-01

    Prompt Gamma Neutron Activation Analysis (PGNAA) systems employ neutrons as a probe to interrogate items, e.g. chemical warfare materiel-filled munitions. The choice of a neutron source in field-portable systems is determined by its ability to excite nuclei of interest, operational concerns such as radiological safety and ease-of-use, and cost. Idaho National Laboratory’s PINS Chemical Assay System has traditionally used a Cf-252 isotopic neutron source, but recently a Deuterium-Tritium (DT) Electronic Neutron Generator (ENG) has been tested as an alternate neutron source. This paper presents the results of using both of these neutron sources to interrogate chemical warfare materiel (CWM) andmore » high explosive (HE) filled munitions.« less

  5. A Comparison of Neutron-Based Non-Destructive Assessment Methods for Chemical Warfare Material and High Explosives

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Seabury, E. H.; Chichester, D. L.; Wharton, C. J.

    2009-03-10

    Prompt Gamma Neutron Activation Analysis (PGNAA) systems employ neutrons as a probe to interrogate items, e.g. chemical warfare materiel-filled munitions. The choice of a neutron source in field-portable systems is determined by its ability to excite nuclei of interest, operational concerns such as radiological safety and ease-of-use, and cost. Idaho National Laboratory's PINS Chemical Assay System has traditionally used a {sup 252}Cf isotopic neutron source, but recently a deuterium-tritium (DT) electronic neutron generator (ENG) has been tested as an alternate neutron source. This paper presents the results of using both of these neutron sources to interrogate chemical warfare materiel (CWM)more » and high explosive (HE) filled munitions.« less

  6. The interrelationship of complement-activation fragments and angiogenesis-related factors in early pregnancy and their association with pre-eclampsia

    PubMed Central

    Lynch, AM; Murphy, JR; Gibbs, RS; Levine, RJ; Giclas, PC; Salmon, JE; Holers, VM

    2016-01-01

    Objective To determine the interrelationships during early pregnancy of complement-activation fragments Bb, C3a and sC5b-9, and angiogenesis-related factors placental growth factor (PiGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), and their associations with pre-eclampsia. Design Prospective cohort study. Setting Denver complement study (June 2005–June 2008). Population A total of 668 pregnant women with singleton gestations, recruited between 10 and 15 weeks of gestation. Methods Using univariable and multivariable logistic regression analysis, concentrations of complement-activation fragments and angiogenesis-related factors were compared between 10 and 15 weeks of gestation in women who subsequently did or did not develop pre-eclampsia. Interrelationships between these variables were tested using the non-parametric Spearman rank correlation coefficient. Main outcome measure Pre-eclampsia. The association of complement-activation fragments and angiogenesis-related factors with obesity was also examined. Results The mean (±SD) levels of complement Bb in early pregnancy among women who did and did not develop pre-eclampsia were 0.84 (±0.26) µg/ml and 0.69 (±0.2) µg/ml, respectively (P = 0.001). Concentrations of PiGF were significantly (P = 0.01) lower (31 ± 12 pg/ml) in early pregnancy in the pre-eclamptic group of women, as compared with the normotensive group (39 ± 32 pg/ml). The adjusted odds ratio (AOR) of Bb and PiGF were 2.1 (CI = 1.4–3.1, P < 0.0003) and 0.2 (CI = 0.07–0.7, P = 0.01), respectively. There was no significant difference in the levels of C3a, sC5b-9, sFlt-1 and sEng in early pregnancy among women who developed pre-eclampsia, compared with women who remained normotensive during pregnancy. Higher levels of Bb (P = 0.0001) and C3a (P = 0.03), and lower levels of sFlt-1 (P = 0.0002) and sEng (P = 0.0001) were found among women with obesity, compared with non-obese controls. No meaningful relationships were found between the complement-activation fragments and the angiogenesis-related factors. Conclusions In this cohort during early pregnancy, increased concentrations of complement-activation factor Bb and lower concentrations of PiGF were associated with the development of pre-eclampsia later in pregnancy. PMID:20074261

  7. Frictional weakening of Landslides in the Solar System

    NASA Astrophysics Data System (ADS)

    Lucas, Antoine; Mangeney, Anne; Ampuero, Jean-Paul

    2014-05-01

    Landslides are an important phenomenon that shapes the surface morphology of solid planetary bodies, including planets and small bodies. In addition, landslide science aims to predict the maximum distance travelled and the maximum velocity reached by a potential landslide in order to quantify the damage it may cause. On the one hand, observations show that the so-called Heim's ratio (i.e. the ratio between the difference of the height of the initial mass and that of the deposit, and the traveling distance) decreases with increasing volume for landslides observed on Earth [1] and other planets like Mars and icy moons like Iapetus [2], but whether this quantity is a good representation of the effective friction during the flow is still a controversial issue. On the other hand, numerical simulations (either continuous or discrete) of real landslides commonly require the assumption of very small friction coefficient to reproduce the extension of deposits [2-5]. We investigate if a common origin can explain the characteristics of landslides in such variety of planetary environments. Based on analytical and numerical solutions for granular flows constrained by remote-sensing observations [3, 7], we developed a consistent method to estimate the effective friction coefficient of landslides, i.e., the constant basal friction coefficient that reproduces their first-order properties. We show that: i) the Heim's ratio is not equivalent to the effective friction coefficient; ii) the friction coefficient decreases with increasing volume or, more fundamentally, with increasing sliding velocity. Inspired by frictional weakening mechanisms thought to operate during earthquakes [8], we propose an empirical velocity-weakening friction law under an unifying phenomenological framework applicable to small to large landslides observed on Earth and beyond (including icy moons of giant planets) whatever the environment and material involved. References: [1] Legros, Eng. Geol. 2002; [2] Lucas, Nat. Geosc. News & Views, 2012. [3] Lucas & Mangeney, GRL, 2007. [4] Pudasaini & Hutter, Springer, 2007. [5] Campbell et al., JGR, 1995. [6] Smart et al., AGU Fall Meeting, 2010. [7] Lucas et al., JGR, 2011. [8] Rice, JGR, 2006. N.B. This work is subject to press embargo.

  8. Simulation of wind-driven dispersion of fire pollutants in a street canyon using FDS.

    PubMed

    Pesic, Dusica J; Blagojevic, Milan Dj; Zivkovic, Nenad V

    2014-01-01

    Air quality in urban areas attracts great attention due to increasing pollutant emissions and their negative effects on human health and environment. Numerous studies, such as those by Mouilleau and Champassith (J Loss Prevent Proc 22(3): 316-323, 2009), Xie et al. (J Hydrodyn 21(1): 108-117, 2009), and Yassin (Environ Sci Pollut Res 20(6): 3975-3988, 2013) focus on the air pollutant dispersion with no buoyancy effect or weak buoyancy effect. A few studies, such as those by Hu et al. (J Hazard Mater 166(1): 394-406, 2009; J Hazard Mater 192(3): 940-948, 2011; J Civ Eng Manag (2013)) focus on the fire-induced dispersion of pollutants with heat buoyancy release rate in the range from 0.5 to 20 MW. However, the air pollution source might very often be concentrated and intensive, as a consequence of the hazardous materials fire. Namely, transportation of fuel through urban areas occurs regularly, because it is often impossible to find alternative supply routes. It is accompanied with the risk of fire accident occurrences. Accident prevention strategies require analysis of the worst scenarios in which fire products jeopardize the exposed population and environment. The aim of this article is to analyze the impact of wind flow on air pollution and human vulnerability to fire products in a street canyon. For simulation of the gasoline tanker truck fire as a result of a multivehicle accident, computational fluid dynamics large eddy simulation method has been used. Numerical results show that the fire products flow vertically upward, without touching the walls of the buildings in the absence of wind. However, when the wind velocity reaches the critical value, the products touch the walls of the buildings on both sides of the street canyon. The concentrations of carbon monoxide and soot decrease, whereas carbon dioxide concentration increases with the rise of height above the street canyon ground level. The longitudinal concentration of the pollutants inside the street increases with the rise of the wind velocity at the roof level of the street canyon.

  9. Apparent and microscopic dynamic contact angles in confined flows

    NASA Astrophysics Data System (ADS)

    Omori, Takeshi; Kajishima, Takeo

    2017-11-01

    An abundance of empirical correlations between a dynamic contact angle and a capillary number representing a translational velocity of a contact line have been provided for the last decades. The experimentally obtained dynamic contact angles are inevitably apparent contact angles but often undistinguished from microscopic contact angles formed right on the wall. As Bonn et al. ["Wetting and spreading," Rev. Mod. Phys. 81, 739-805 (2009)] pointed out, however, most of the experimental studies simply report values of angles recorded at some length scale which is quantitatively unknown. It is therefore hard to evaluate or judge the physical validity and the generality of the empirical correlations. The present study is an attempt to clear this clutter regarding the dynamic contact angle by measuring both the apparent and the microscopic dynamic contact angles from the identical data sets in a well-controlled manner, by means of numerical simulation. The numerical method was constructed so that it reproduced the fine details of the flow with a moving contact line predicted by molecular dynamics simulations [T. Qian, X. Wang, and P. Sheng, "Molecular hydrodynamics of the moving contact line in two-phase immiscible flows," Commun. Comput. Phys. 1, 1-52 (2006)]. We show that the microscopic contact angle as a function of the capillary number has the same form as Blake's molecular-kinetic model [T. Blake and J. Haynes, "Kinetics of liquid/liquid displacement," J. Colloid Interface Sci. 30, 421-423 (1969)], regardless of the way the flow is driven, the channel width, the mechanical properties of the receding fluid, and the value of the equilibrium contact angle under the conditions where the Reynolds and capillary numbers are small. We have also found that the apparent contact angle obtained by the arc-fitting of the interface behaves surprisingly universally as claimed in experimental studies in the literature [e.g., X. Li et al., "An experimental study on dynamic pore wettability," Chem. Eng. Sci. 104, 988-997 (2013)], although the angle deviates significantly from the microscopic contact angle. It leads to a practically important point that it suffices to measure arc-fitted contact angles to make formulae to predict flow rates in capillary tubes.

  10. 46 CFR 160.135-3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., the term: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop 7509, 2703 Martin... the position before displacement. SOLAS means the International Convention for the Safety of Life at...

  11. 46 CFR 160.135-3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., the term: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop 7509, 2703 Martin... the position before displacement. SOLAS means the International Convention for the Safety of Life at...

  12. 46 CFR 154.449 - Model test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction and Equipment Independent Tank Type B § 154.449 Model test. The following analyzed data of a model test of structural elements for independent tank type B must be submitted to the Commandant (CG-ENG) for special approval: (a) Stress concentration...

  13. Try This: Construct a Water Catchment

    ERIC Educational Resources Information Center

    Teaching Science, 2017

    2017-01-01

    EngQuest, an initiative of Engineers Australia, provides an exciting, non-competitive way for students to participate in free, fun and educational engineering activities involving mathematics, science and technology. This article describes a project designed to teach middle school students how to construct a water catchment system. Water…

  14. Constructing a Waterwheel

    ERIC Educational Resources Information Center

    Teaching Science, 2015

    2015-01-01

    EngQuest, an initiative of Engineers Australia, provides an exciting, non-competitive way for students to participate in free, fun and educational engineering activities involving mathematics, science and technology. This article provides a sample of one of the middle school activities in the program. The history of water wheels, and their use…

  15. Capability Portfolio Analysis Tool (CPAT) Verification and Validation Report

    DTIC Science & Technology

    2013-01-01

    BFSB Battlefield Surveillance Brigade BFV Bradley Fighting Vehicle BMOD Bradley Modernization C2 (H) Command and Control (HBCT) C2 (S...Fire Infantry Fighting Vehicle (IFV); Fire Integrated Support Team (FIST); Engineer (Eng); Cavalry (CAV) BFV FOV CDD Block II - 16 Apr 2010 GCV FOV

  16. GLEEM Testing Fixture

    DTIC Science & Technology

    2009-07-01

    TEAM AMSIO SMT R CRAWFORD W HARRIS 1 ROCK ISLAND ARSENAL ROCK ISLAND IL 61299-6000 7 BENET LABS AMSTA AR CCB M SOJA E KATHE...SPENCER LAB NEWARK DE 19716 1 DEPT OF MECH ENG UNIV OF NEVADA LAS VEGAS M TRABIA 4505 MARYLAND PKWY BOX 454027 LAS VEGAS NV

  17. Electrical Engineering (Selected Articles).

    DTIC Science & Technology

    1980-05-15

    Homopolar Machine with Sodium-Potassium Ring-Shaped Contacts, by L.A. Sukhanov , G.A. Karmonov .......... 19 ACCESSION forWht hieSeto NTISuf ecine 1DOCS...3663 FACE 19 DIFECT-CURRENT HOMOPOLAS AACHIhI ITH SCIIUM-ECIASSIUM RING-SHAPED CONTACTS L. A. Sukhanov , Cand. tech. sciences, G. A. Karmanov, eng. ThA

  18. 46 CFR 160.171-3 - Incorporation by reference.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... at Coast Guard Headquarters. Contact Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division... Building, Room 6039, 7th and D Streets SW, Washington, DC 20407. National Bureau of Standards Special... January 25, 1965. Underwriters Laboratories, Inc. 12 Laboratory Drive, Research Triangle Park, NC 27709...

  19. 46 CFR 160.171-3 - Incorporation by reference.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... at Coast Guard Headquarters. Contact Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division... Building, Room 6039, 7th and D Streets SW, Washington, DC 20407. National Bureau of Standards Special... January 25, 1965. Underwriters Laboratories, Inc. 12 Laboratory Drive, Research Triangle Park, NC 27709...

  20. 5. Photocopy of engraving (from J.H.D. Wingfield, The Northern California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photocopy of engraving (from J.H.D. Wingfield, The Northern California Mission, ca. 1882, p. 3) Moss Eng. Co. N.Y. ca. 1882 SOUTH SIDE AND EAST FRONT - Bishop J. H. D. Wingfield House, 36 Wingfield Way, Benicia, Solano County, CA

  1. A SUBSET OF PATIENTS DESTINED TO DEVELOP SPONTANEOUS PRETERM LABOR HAS AN ABNORMAL ANGIOGENIC/ANTI-ANGIOGENIC PROFILE IN MATERNAL PLASMA: EVIDENCE IN SUPPORT OF PATHOPHYSIOLOGIC HETEROGENEITY OF PRETERM LABOR DERIVED FROM A LONGITUDINAL STUDY

    PubMed Central

    Chaiworapongsa, Tinnakorn; Romero, Roberto; Tarca, Adi; Kusanovic, Juan Pedro; Mittal, Pooja; Kim, Sun Kwon; Gotsch, Francesca; Erez, Offer; Vaisbuch, Edi; Mazaki-Tovi, Shali; Pacora, Percy; Ogge, Giovanna; Dong, Zhong; Kim, Chong Jai; Yeo, Lami; Hassan, Sonia S

    2012-01-01

    OBJECTIVE An imbalance between angiogenic and anti-angiogenic factors in maternal blood has been observed in several obstetrical syndromes including preeclampsia, pregnancies with fetal growth restriction, and fetal death. Vascular lesions have been identified in a subset of patients with spontaneous preterm labor (PTL). It is possible that PTL may be one of the manifestations of an anti-angiogenic state. The aim of this study was to determine if patients prior to the clinical diagnosis of PTL leading to preterm delivery had plasma concentrations of angiogenic and anti-angiogenic factors different from normal pregnant women. STUDY DESIGN This longitudinal nested case-control study included normal pregnant women (n=208) and patients with PTL leading to preterm delivery (n=52). Maternal blood samples were collected at 6 gestational age intervals from 6-36.9 weeks of gestation. The end point (time of diagnosis) of the study, “True PTL”, was defined as patients presenting with PTL and delivered within 1 day. Plasma concentrations of sVEGFR-1, sVEGFR-2, sEng and PlGF were determined by ELISA. Analysis was performed with both cross-sectional and longitudinal (mixed effects model) approaches. RESULTS 1) Plasma sEng concentration in patients destined to develop PTL was higher than that in normal pregnant women from 15-20 weeks of gestation. The difference became statistical significant at 28 weeks of gestation, or approximately 5-10 weeks prior to the diagnosis of “true PTL”. 2) Backward analysis suggests that plasma concentrations of PlGF and sVEGFR-2 were lower, and those of sVEGFR-1 were higher in patients with PTL than in normal pregnant women less than 5 weeks prior to the diagnosis of “true PTL”; and 3) Plasma concentrations of sEng and sVEGFR-1 were higher and those of PlGF and sVEGFR-2 were lower in patents diagnosed with PTL and delivery within 1 day than in normal pregnant women who delivered at term. CONCLUSION The changes in sEng are demonstrable several weeks prior to the onset of preterm parturition. In contrast, the changes in the other angiogenic proteins are present close to the onset of PTL and delivery. This observation supports the view that an imbalance of angiogenic factors participates in the pathophysiology of spontaneous preterm parturition. PMID:19916710

  2. Commentary on the Integration of Model Sharing and Reproducibility Analysis to Scholarly Publishing Workflow in Computational Biomechanics

    PubMed Central

    Erdemir, Ahmet; Guess, Trent M.; Halloran, Jason P.; Modenese, Luca; Reinbolt, Jeffrey A.; Thelen, Darryl G.; Umberger, Brian R.

    2016-01-01

    Objective The overall goal of this document is to demonstrate that dissemination of models and analyses for assessing the reproducibility of simulation results can be incorporated in the scientific review process in biomechanics. Methods As part of a special issue on model sharing and reproducibility in IEEE Transactions on Biomedical Engineering, two manuscripts on computational biomechanics were submitted: A. Rajagopal et al., IEEE Trans. Biomed. Eng., 2016 and A. Schmitz and D. Piovesan, IEEE Trans. Biomed. Eng., 2016. Models used in these studies were shared with the scientific reviewers and the public. In addition to the standard review of the manuscripts, the reviewers downloaded the models and performed simulations that reproduced results reported in the studies. Results There was general agreement between simulation results of the authors and those of the reviewers. Discrepancies were resolved during the necessary revisions. The manuscripts and instructions for download and simulation were updated in response to the reviewers’ feedback; changes that may otherwise have been missed if explicit model sharing and simulation reproducibility analysis were not conducted in the review process. Increased burden on the authors and the reviewers, to facilitate model sharing and to repeat simulations, were noted. Conclusion When the authors of computational biomechanics studies provide access to models and data, the scientific reviewers can download and thoroughly explore the model, perform simulations, and evaluate simulation reproducibility beyond the traditional manuscript-only review process. Significance Model sharing and reproducibility analysis in scholarly publishing will result in a more rigorous review process, which will enhance the quality of modeling and simulation studies and inform future users of computational models. PMID:28072567

  3. Pharmacokinetics and ovarian suppression during use of a contraceptive vaginal ring in normal-weight and obese women

    PubMed Central

    WESTHOFF, Carolyn L.; TORGAL, Anupama H.; MAYEDA, Elizabeth Rose; PETRIE, Kelsey; THOMAS, Tiffany; DRAGOMAN, Monica; CREMERS, Serge

    2012-01-01

    BACKGROUND Many observational studies indicate higher oral contraceptive failure among obese women, but most clinical trials and physiological studies do not support these differences. Limited data indicate higher failure rates among obese contraceptive patch users. Data regarding contraceptive vaginal ring (CVR) performance in obese women are needed. METHODS 20 normal weight (BMI 19.0–24.9, median 21.65) and 20 obese (BMI 30.0–39.9, median 33.7) women enrolled in a prospective study of ethinyl estradiol (EE) and etonorgestrel (ENG) pharmacokinetics and of ovarian follicle development, endometrial thickness, and bleeding patterns, all measured biweekly during the second cycle of CVR use. RESULTS Thirty-seven women completed follow-up. Mean day 0–21 EE concentrations were lower among obese versus normal weight women (15.0 versus 22.0 pg/mL, respectively. p = 0.004), while ENG concentrations were similar (1138 versus 1256 pg/mL, respectively. p = 0.39). Follicular development was minimal in both groups, with only five women achieving a maximum follicle diameter > 13mm at any time during 3 weeks follow-up (3 normal weight and 2 obese women); these women had serum progesterone levels < 1.0. Obese women reported more bleeding or spotting than normal weight women (3.6 versus 1.4 days, respectively. p = 0.01). CONCLUSIONS While obese women had lower EE levels during CVR use, they had excellent suppression of ovarian follicle development, similar to normal weight women. This predicts that CVR effectiveness will be similar in women with a BMI up to 39.9. The lower serum EE levels in the obese women may explain the greater reported bleeding or spotting days. PMID:22727346

  4. Variation in Telangiectasia Predisposing Genes Is Associated With Overall Radiation Toxicity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tanteles, George A.; Department of Cancer Studies and Molecular Medicine, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester; Murray, Robert J.S.

    2012-11-15

    Purpose: In patients receiving radiotherapy for breast cancer where the heart is within the radiation field, cutaneous telangiectasiae could be a marker of potential radiation-induced heart disease. We hypothesized that single nucleotide polymorphisms (SNPs) in genes known to cause heritable telangiectasia-associated disorders could predispose to such late, normal tissue vascular damage. Methods and Materials: The relationship between cutaneous telangiectasia as a late normal tissue radiation injury phenotype in 633 breast cancer patients treated with radiotherapy was examined. Patients were clinically assessed for the presence of cutaneous telangiectasia and genotyped at nine SNPs in three candidate genes. Candidate SNPs were withinmore » the endoglin (ENG) and activin A receptor, type II-like 1 (ACVRL1) genes, mutations in which cause hereditary hemorrhagic telangiectasia and the ataxia-telangiectasia mutated (ATM) gene associated with ataxia-telangiectasia. Results: A total of 121 (19.1%) patients exhibited a degree of cutaneous telangiectasiae on clinical examination. Regression was used to examine the associations between the presence of telangiectasiae in patients who underwent breast-conserving surgery, controlling for the effects of boost and known brassiere size (n=388), and individual geno- or haplotypes. Inheritance of ACVRL1 SNPs marginally contributed to the risk of cutaneous telangiectasiae. Haplotypic analysis revealed a stronger association between inheritance of a ATM haplotype and the presence of cutaneous telangiectasiae, fibrosis and overall toxicity. No significant association was observed between telangiectasiae and the coinheritance of the candidate ENG SNPs. Conclusions: Genetic variation in the ATM gene influences reaction to radiotherapy through both vascular damage and increased fibrosis. The predisposing variation in the ATM gene will need to be better defined to optimize it as a predictive marker for assessing radiotherapy late effects.« less

  5. A Comparative Theoretical and Computational Study on Robust Counterpart Optimization: II. Probabilistic Guarantees on Constraint Satisfaction

    PubMed Central

    Li, Zukui; Floudas, Christodoulos A.

    2012-01-01

    Probabilistic guarantees on constraint satisfaction for robust counterpart optimization are studied in this paper. The robust counterpart optimization formulations studied are derived from box, ellipsoidal, polyhedral, “interval+ellipsoidal” and “interval+polyhedral” uncertainty sets (Li, Z., Ding, R., and Floudas, C.A., A Comparative Theoretical and Computational Study on Robust Counterpart Optimization: I. Robust Linear and Robust Mixed Integer Linear Optimization, Ind. Eng. Chem. Res, 2011, 50, 10567). For those robust counterpart optimization formulations, their corresponding probability bounds on constraint satisfaction are derived for different types of uncertainty characteristic (i.e., bounded or unbounded uncertainty, with or without detailed probability distribution information). The findings of this work extend the results in the literature and provide greater flexibility for robust optimization practitioners in choosing tighter probability bounds so as to find less conservative robust solutions. Extensive numerical studies are performed to compare the tightness of the different probability bounds and the conservatism of different robust counterpart optimization formulations. Guiding rules for the selection of robust counterpart optimization models and for the determination of the size of the uncertainty set are discussed. Applications in production planning and process scheduling problems are presented. PMID:23329868

  6. Crash causal factors and countermeasures for high-risk locations on multilane primary highways in Virginia.

    DOT National Transportation Integrated Search

    2009-01-01

    In 2004, a total of 95,020 vehicle crashes occurred on highways under the jurisdiction of the Virginia Department of Transportation (VDOT). Of these, 39,847 crashes occurred on primary highways, and 345 of these were fatal crashes. VDOT's traffic eng...

  7. Enduring U.S. Interests in the Persian Gulf Region

    DTIC Science & Technology

    2012-03-02

    building partner capacity” ( BPC ). BPC is part of a larger security assistance framework which provides defense articles, military training, and...Santa Monica, CA: Rand, 2010), 157 . 15The Cooperation Council for the Arab States of the Gulf; http://www.gcc-sg.org/eng/ indexfc7a.html?action=Sec

  8. 46 CFR 147.5 - Commandant (CG-OES); address.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Commandant (CG-OES); address. 147.5 Section 147.5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES HAZARDOUS SHIPS' STORES General Provisions § 147.5 Commandant (CG-OES); address. Commandant (CG-ENG) is the Office of Design and...

  9. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Exceptions to the compatibility chart. 150.150 Section 150.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (CG-ENG-5...

  10. 46 CFR 147.5 - Commandant (CG-OES); address.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Commandant (CG-OES); address. 147.5 Section 147.5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES HAZARDOUS SHIPS' STORES General Provisions § 147.5 Commandant (CG-OES); address. Commandant (CG-ENG) is the Office of Design and...

  11. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Exceptions to the compatibility chart. 150.150 Section 150.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (CG-ENG-5...

  12. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Exceptions to the compatibility chart. 150.150 Section 150.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (CG-ENG-5...

  13. High Temperature Oxidation and Electrochemical Studies Related to Hot Corrosion.

    DTIC Science & Technology

    1987-12-01

    Birnbaum Dept. of Metallurgy & Mining Eng. Dr. W. C. Moshier University of Illinois Martin Marietta Laboratories Urbana , Ill 61801 1450 South...Defense Metals and Ceramics Command Infor-r.ation Center Alexandria, VA 22331 Battelle Memoria !nsri~ure ATTn: Code 03 1 505 King Avenue Columbus, OH

  14. Can Canada Avoid Arctic Militarization?

    DTIC Science & Technology

    2014-05-20

    William Barr. Calgary, AB: University of Alberta Press, 2004. Dolata-Kreutzkamp, Petra . “Canada’s Arctic Policy: Transcending the Middle Power Model?” In... Martin . “Due North”, Canadian Military Journal, 8, no. 1 (Spring 2007): 103-4. http://www.journal.forces.gc.ca/vo8/no1/doc/shadwick-eng.pdf

  15. 46 CFR 160.132-3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...), in this subpart, the term: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop... described. SOLAS means the International Convention for the Safety of Life at Sea, 1974, as amended. [USCG...

  16. 46 CFR 160.151-3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... subpart, the term: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop 7509...-57. SOLAS means the International Convention for the Safety of Life at Sea, 1974, as amended by the...

  17. 46 CFR 160.132-3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...), in this subpart, the term: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop... described. SOLAS means the International Convention for the Safety of Life at Sea, 1974, as amended. [USCG...

  18. 46 CFR 160.151-3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... subpart, the term: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop 7509...-57. SOLAS means the International Convention for the Safety of Life at Sea, 1974, as amended by the...

  19. 46 CFR 160.133-3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop 7509, 2703 Martin Luther King Jr. Avenue SE... International Convention for the Safety of Life at Sea, 1974, as amended. [USCG-2010-0048, 76 FR 62983, Oct. 11...

  20. 46 CFR 160.115-3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...), in this subpart, the term: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop... described. SOLAS means the International Convention for the Safety of Life at Sea, 1974, as amended. [USCG...

  1. 46 CFR 160.115-3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...), in this subpart, the term: Commandant means the Chief of the Lifesaving and Fire Safety Standards Division. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop... described. SOLAS means the International Convention for the Safety of Life at Sea, 1974, as amended. [USCG...

  2. Materials Research Society, Symposium Proceedings, Volume 521. Porous and Cellular Materials for Structural Applications

    DTIC Science & Technology

    1998-04-15

    UTRC GmbH, Technologiezentrum, Am Europaplatz, D-52068 Aachen, Germany. SaenzE@ctaero.com **UTRC, S.L. c/o CTA Parque Tecnologico de...Alava. 01510 Mifiano (Alava). Spain. barandap @ eng 1 .otis .com ***ITMA, Parque Tecnologico de Asturias, 33 428 Corufio-Llanera, Spain

  3. Maximizing Empower on a Human-dominated Planet: The Role of Exotic Spartina (Eco Eng.)

    EPA Science Inventory

    The emergy signature of the Earth has changed dramatically over the past 250 years as a result of the development of technologies to use fossil fuels for human purposes. This change has resulted in the self-organization of modern industrial societies and their concomitant process...

  4. Phase Field Modeling of Twinning in Indentation of Transparent Crystals

    DTIC Science & Technology

    2011-09-01

    agrees with observations from indentation experiments conducted from the 1930s to the 1970s [1, 5, 8, 11]. Long, lenticular -shaped micro-twins in...stress distributions favor formation of lenticular shaped twins, and that above a 24 Modelling Simul. Mater. Sci. Eng. 19 (2011) 085005 J D Clayton

  5. 46 CFR 52.01-1 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS General... inspection at the U.S. Coast Guard, Office of Design and Engineering Standards (CG-ENG), 2100 2nd St., SW... Society of Mechanical Engineers (ASME) International, Three Park Avenue, New York, NY 10016-5990: (1) 2001...

  6. Darwin als Sehhilfe für die Psychologie - Evolutionspsychologie

    NASA Astrophysics Data System (ADS)

    Schwab, Frank

    Im Folgenden geht es um Einäugige, stereoskopisches Sehen, weite und enge Horizonte, Monokel und Sonnenbrillen. Der Beitrag versucht die Metapher des Sehens und der Sehhilfen anzuwenden, um so zu verdeutlichen, welchen Gewinn die herkömmliche Psychologie durch die Verwendung einer Darwin'schen Brille erlangen kann.

  7. 46 CFR 34.01-15 - Incorporation by reference.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Systems, IBR approved for § 34.30-1 (“NFPA 13-1996”). (2) NFPA 2001, Standard on Clean Agent Fire... Headquarters. Contact Commandant (CG-ENG), Attn: Office of Design and Engineering Systems, U.S. Coast Guard... F1121-87 (Reapproved 2010), Standard Specification for International Shore Connections for Marine Fire...

  8. 46 CFR 34.01-15 - Incorporation by reference.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Systems, IBR approved for § 34.30-1 (“NFPA 13-1996”). (2) NFPA 2001, Standard on Clean Agent Fire... Headquarters. Contact Commandant (CG-ENG), Attn: Office of Design and Engineering Systems, U.S. Coast Guard... F1121-87 (Reapproved 2010), Standard Specification for International Shore Connections for Marine Fire...

  9. Global Positioning System Multipath Reduction with Correlator Beamforming

    DTIC Science & Technology

    2014-03-14

    Collins (Member) Date //signed// 14 March 2014 Maj Marshall E. Haker (Member) Date AFIT-ENG-14-M-10 Abstract This research effort investigates the...Ohio Univerisity, 2007. 6. Haker , Marshall E. Modeling the Effects of the Local Environment on a Received GNSS Signal. Ph.D. thesis, Air Force Institute

  10. Aluminum Alloy 7068 Mechanical Characterization

    DTIC Science & Technology

    2009-08-01

    WARREN MI 48397-5000 7 BENET LABS AMSTA AR CCB M SOJA E KATHE G SPENCER P WHEELER S KRUPSKI J VASILAKIS G FRIAR WATERVLIET...DEPT OF MECH ENG UNIV OF NEVADA LAS VEGAS M TRABIA 4505 MARYLAND PKWY BOX 454027 LAS VEGAS NV 89154-4027 NO. OF NO. OF COPIES

  11. Preparation for the Implantation of an Intracortical Visual Prosthesis in a Human

    DTIC Science & Technology

    2015-12-01

    cluster of the WFMA. Electrode current flows between the micro-(working) electrode and a longer large-area counter electrode, using either...Biomed Eng 44(10):931-9. McCreery DB, Yuen TGH, Agnew, WF, Bullara LA (2000). Chronic microstimulation in the feline ventral cochlear nucleus

  12. 46 CFR 160.171-3 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... at the U.S. Coast Guard, Lifesaving and Fire Safety Division (CG-ENG-4), 2100 2nd St., SW., Stop 7126.... National Bureau of Standards Special Publication 440—Color, Universal Language and Dictionary of Names..., Stitches, Seams, and Stitchings, dated January 25, 1965. Underwriters Laboratories, Inc. 12 Laboratory...

  13. 46 CFR 160.076-11 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the public. All approved material is available for inspection at the National Archives and Records Administration (NARA) and at the U.S. Coast Guard, Lifesaving and Fire Safety Division (CG-ENG-4), 2100 2nd St...) Underwriters Laboratories (UL) Underwriters Laboratories, Inc., 333 Pfingsten Road, Northbrook, IL 60062-2096...

  14. 46 CFR 164.013-2 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... All approved material incorporated by reference may be inspected at the National Archives and Records Administration (NARA), and at the U.S. Coast Guard, Lifesaving and Fire Safety Division (CG-ENG-4), 2100 2nd St... as follows: Underwriters Laboratories (UL) Underwriters Laboratories, Inc., P.O. Box 13995, Research...

  15. Promoting Japan and South Korea’s Role in East Asian Security

    DTIC Science & Technology

    2010-02-01

    activity. 29 The Spratly Islands are currently claimed by China, Taiwan, Vietnam, Malaysia , Brunei, and the Philippines30 while the Paracel Islands...The National Diet of Japan, The Constitution of Japan, November 3, 1946, linked from the House of Councillors Homepage, http://www.sangiin.go.jp/eng

  16. [Specific characteristics of French immigration to Canada in the aftermath of the Second World War].

    PubMed

    Jones, R

    1986-11-01

    French immigration to Canada in the years immediately following World War II and policies affecting it are discussed. Particular attention is given to changes in Canadian immigration regulations and their enforcement, given concerns about Communists immigrating from France. (SUMMARY IN ENG AND SPA)

  17. Field implementation of fiber-reinforced polymer (FRP) deck panels.

    DOT National Transportation Integrated Search

    2017-06-01

    Jeffery S. Volz, S.E., P.E., Ph.D., Kamal H. Khayat, PhD, P.Eng. http://orcid.org/0000-0003-1431-0715, Soo Duck Hwang, Ph.D. http://orcid.org/0000-0003-2178-1531, Hesham Tuwair, Ph.D., Jonathan T. Drury, Amy S. Crone : Although still in their infancy...

  18. [Marriage and divorce in Japan].

    PubMed

    Haderka, J

    1986-01-01

    Marriage patterns in Japan are analyzed using data from secondary sources. The author notes that although legislation affecting marriage and the family is derived from European models, traditional Japanese attitudes concerning the subservient role of women have a significant impact. The problems faced by women experiencing divorce are noted. (SUMMARY IN ENG AND RUS)

  19. Evaluation and Testing of the Suitability of a Coal-Based Jet Fuel

    DTIC Science & Technology

    2008-06-01

    accepted that higher aromatic content increases particulate matter formation during combustion ( Naegeli and Moses, 1980; Monroig et al., 2005...Alkyl Groups. Ind. Eng. Chem. Fundam. 23, 288-294. Naegeli , D. W., Moses, C.A., 1980. Effects of Fuel Molecular Structure on Soot Formation in Gas

  20. Percolation and permeability of fracture networks in Excavated Damaged Zones

    NASA Astrophysics Data System (ADS)

    Mourzenko, V.; Thovert, J.; Adler, P. M.

    2012-12-01

    Generally, the excavation process of a gallery generates fractures in its immediate vicinity. The corresponding zone which is called the Excavated Damaged Zone (EDZ), has a larger permeability than the intact surrounding medium. The properties of the EDZ are attracting more and more attention because of their potential importance in repositories of nuclear wastes. The EDZ which is induced by the excavation process may create along the galleries of the repositories a high permeability zone which could directly connect the storage area with the ground surface. Therefore, the studies of its properties are of crucial importance for applications such as the storage of nuclear wastes. Field observations (such as the ones which have been systematically performed at Mont Terri by [1, 2]) suggest that the fracture density is an exponentially decreasing function of the distance to the wall with a characteristic length of about 0.5 m and that the fracture orientation is anisotropic (most fractures are subparallel to the tunnel walls) and well approximated by a Fisher law whose pole is orthogonal to the wall. Numerical samples are generated according to these prescriptions. Their percolation status and hydraulic transmissivity can be calculated by the numerical codes which are detailed in [3]. Percolation is determined by a pseudo diffusion algorithm. Flow determination necessitates the meshing of the fracture networks and the discretisation of the Darcy equation by a finite volume technique; the resulting linear system is solved by a conjugate gradient algorithm. Only the flow properties of the EDZ along the directions which are parallel to the wall are of interest when a pressure gradient parallel to the wall is applied. The transmissivity T which relates the total flow rate per unit width Q along the wall through the whole EDZ to the pressure gradient grad p, is defined by Q = - T grad p/mu where mu is the fluid viscosity. The percolation status and hydraulic transmissivity are systematically determined for a wide range of decay lengths and anisotropy parameters. They can be modeled by comparison with anisotropic fracture networks with a constant density. A heuristic power-law model is proposed which accurately describes the results for the percolation threshold over the whole investigated range of heterogeneity and anisotropy. Then, the data for the EDZ transmissivity are presented. A simple parallel flow model is introduced. The flow properties of the EDZ vary with the distance z from the wall. However, the macroscopic pressure gradient does not depend on z, and the flow lines are in average parallel to the wall. Hence, the overall transmissivity is tentatively estimated by a parallel flow model, where a layer at depth z behaves as a fractured medium with uniform properties corresponding to the state at this position in the EDZ. It yields an explicit analytical expression for the transmissivity as a function of the heterogeneity and anisotropy parameters, and it successfully accounts for all the numerical data. Graphical tools are provided from which first estimates can be quickly and easily obtained. [1] Bossart P. et al, Eng. Geol., vol. 66, 19-38 (2002). [2] Thovert J.-F. et al, Eng. Geol., 117, 39-51 (2011). [3] Adler P.M. et al, Fractured porous media, Oxford U. Press, in press.

  1. Mechanical Design of Innovative Electromagnetic Linear Actuators for Marine Applications

    NASA Astrophysics Data System (ADS)

    Muscia, Roberto

    2017-11-01

    We describe an engineering solution to manufacture electromagnetic linear actuators for moving rudders and fin stabilizers of military shipsItalian Ministry of Defence, General Direction of Naval Equipments (NAVARM), Projects ISO (2012-2014) and EDDA (2015-2017). . The solution defines the transition from the conceptual design of the device initially studied from an electromagnetic point of view to mechanical configurations that really work. The structural problems that have been resolved with the proposed configuration are described. In order to validate the design choices discussed we illustrate some results of the numerical simulations performed by the structural finite elements method. These results quantitatively justify the suggested mechanical solution by evaluating stresses and deformations in a virtual prototype of the structure during its functioning. The parts of the device that have been studied are the most critical because in cases of excessive deformation/stress, they can irreparably compromise the actuator operation. These parts are the pole piece-base set and the retention cages of the permanent magnets. The FEM analysis has allowed us to identify the most stressed areas of the previous elements whose shape has been appropriately designed so as to reduce the maximum stresses and deformations. Moreover, the FEM analysis helped to find the most convenient solution to join the pole pieces to the respective bases. The good results obtained by the suggested engineering solution have been experimentally confirmed by tests on a small prototype actuator purposely manufactured. Finally, a qualitative analysis of the engineering problems that have to be considered to design electromagnetic linear actuators bigger than the one already manufactured is illustrated.

  2. Non-destructive evaluation means and method of flaw reconstruction utilizing an ultrasonic multi-viewing transducer data acquistion system

    DOEpatents

    Thompson, Donald O.; Wormley, Samuel J.

    1989-03-28

    A multi-viewing ultrasound transducer acquisition system for non-destructive evaluation, flaw detection and flaw reconstruction in materials. A multiple transducer assembly includes a central transducer surrounded by a plurality of perimeter transducers, each perimeter transducer having an axis of transmission which can be angularly oriented with respect to the axis of transmission of the central transducer to intersect the axis of transmission of the central transducer. A control apparatus automatically and remotely positions the transducer assembly with respect to the material by a positioning apparatus and adjusts the pe GRANT REFERENCE This invention was conceived and reduced to practice at least in part under a grant from the Department of Energy under Contract No. W-7407-ENG-82.

  3. Tsunami Focusing and Leading Amplitude

    NASA Astrophysics Data System (ADS)

    Kanoglu, U.

    2016-12-01

    Tsunamis transform substantially through spatial and temporal spreading from their source region. This substantial spreading might result unique maximum tsunami wave heights which might be attributed to the source configuration, directivity, the waveguide structures of mid-ocean ridges and continental shelves, focusing and defocusing through submarine seamounts, random focusing due to small changes in bathymetry, dispersion, and, most likely, combination of some of these effects. In terms of the maximum tsunami wave height, after Okal and Synolakis (2016 Geophys. J. Int. 204, 719-735), it is clear that dispersion would be one of the reasons to drive the leading wave amplitude in a tsunami wave train. Okal and Synolakis (2016), referring to this phenomenon as sequencing -later waves in the train becoming higher than the leading one, considered Hammack's (1972, Ph.D. Dissertation, Calif. Inst. Tech., 261 pp) formalism, in addition to LeMéhauté and Wang's (1995 Water waves generated by underwater explosion, World Scientific, 367 pp), to evaluate linear dispersive tsunami propagation from a circular plug uplifted on an ocean of constant depth. They identified transition distance, as the second wave being larger, performing parametric study for the radius of the plug and the depth of the ocean. Here, we extend Okal and Synolakis' (2016) analysis to an initial wave field with a finite crest length and, in addition, to a most common tsunami initial wave form of N-wave (Tadepalli and Synolakis, 1994 Proc. R. Soc. A: Math. Phys. Eng. Sci. 445, 99-112). First, we investigate the focusing feature in the leading-depression side, which enhance tsunami wave height as presented by Kanoglu et al. (2013 Proc. R. Soc. A: Math. Phys. Eng. Sci. 469, 20130015). We then discuss the results in terms of leading wave amplitude presenting a parametric study and identify a simple relation for the transition distance. The solution presented here could be used to better analyze dispersive characteristics of shallow water-wave numerical models and for benchmarking, in addition to the benchmark problems in Synolakis et al. (2008 Pure Appl. Geophys. 165(11-12), 2197-2228). This study received funding from project ASTARTE-Assessment Strategy and Risk Reduction for Tsunamis in Europe, a collaborative project Grant 603839, FP7-ENV2013 6.4-3.

  4. ISALE impact simulations in support of AIDA mission

    NASA Astrophysics Data System (ADS)

    Oklay, Nilda; Vincent, Jean-Baptiste; Michel, Patrick; Schwartz, Stephen

    2016-07-01

    Introduction: The Asteroid Impact Deflection Assessment (AIDA) mission is a joint project of ESA and NASA with two independent spacecraft. ESA's contribution is an observer satellite called Asteroid Impact Mission (AIM, [1]), and NASA's contribution is a projectile called Double Asteroid Redirection Test (DART, [2]). The target of the mission is a near-Earth binary asteroid system (65803) Didymos. The aim is to study the possibility of deflecting an asteroid by using a kinetic impactor, as well as to characterize the internal properties of the target and test various relevant technologies for other missions. The design is that the DART would impact the secondary of the binary system and AIM would characterize the target asteroid, observe the impact event and measure the changes in the relative orbit after the impact. Impact modeling will be used to interpret the results of the AIDA impact event. There are numerous impact simulation codes, which are planned to be used to understand the AIDA impact results. Therefore an international benchmarking program is ongoing for the comparison of the results of various codes on the defined test cases [3]. We will present the results of the test cases performed by iSALE hydrocode. Modeling: In this work we use the iSALE-2D shock physics code [4], which is based on the SALE hydrocode solution algorithm [5]. To simulate hypervelocity impact processes in solid materials SALE was modified to include an elastoplastic constitutive model, fragmentation models, various EOS, and multiple materials [6, 7]. More recent improvements include a modified strength model [8] and a porosity compaction model [4, 9]. References: [1] Michel P. et al., 2016, ASR, submitted [2] Cheng A. F. et al., (2016) PSS, 121, 27-35 [3] Stickle A. M. et al., (2016). 47th LPSC [4] Wünnemann,K. et al., (2006). Icarus, 180:514-527 [5] Amsden, A., et al., (1980) LANL Report, LA-8095:101p. [6] Melosh, H. J., et al., (1992). J. Geophys. Res., 97(E9):14735-14759 [7] Ivanov, B. A., et al., (1997) Int. J. Imp. Eng., 20:411-430; [8] Collins, G. S., et al., (2004). Met. & Planet. Sci., 39:217-231. [9] Collins, G., et al., (2011) Int. J. Imp. Eng., 38:434-439

  5. Lessons Learned and Unlearned from the 2004 Great Sumatran Tsunami.

    NASA Astrophysics Data System (ADS)

    Synolakis, C.; Kanoglu, U.

    2014-12-01

    Huppert & Sparks (2006 Phil Trans Math Phys Eng Sci) wrote It is likely that in the future, we will experience several disasters per year that kill more than 10,000 people. The 2011 Great East Japan Earthquake Disaster alone resulted in more than 20,000 casualties. Synolakis & Bernard (2006 Phil Trans Math Phys Eng Sci) concluded that Before the next Sumatra-type tsunami strikes, we must resolve to create a world that can coexist with the tsunami hazard. The 2011 Japan tsunami dramatically showed that we are not there yet. Despite substantial advances after the 2004 Boxing Day tsunami, substantial challenges remain for improving tsunami hazard mitigation. If the tsunami community appeared at first perplexed in the aftermath of the 2004 tsunami, it was not due to the failure of recognized hydrodynamic paradigms, much as certain geophysical ones and scaling laws failed, but at the worst surprise, the lack of preparedness and education. Synolakis et al. (2008 Pure Appl Geophys) presented standards for tsunami modeling; for both warnings and inundation maps (IMs). Although at least one forecasting methodology has gone through extensive testing, and is now officially in use by the warning centers (WCs), standards need urgently to be formalized for warnings. In Europe, several WCs have been established, but none has yet to issue an operational warning for a hazardous event. If it happens, there might be confusion with possibly contradictory/competing warnings. Never again should there be a repeat of the TEPCO analysis for the safety of the Fukushima NPP. This was primarily due to lacks of familiarity with the context of numerical predictions and experience with real tsunami. The accident was the result of a cascade of stupid errors, almost impossible to ignore by anyone in the field (Synolakis, 26.03.2011 The New York Times). Current practices in tsunami studies for US NPPs and for IMs do not provide us with optimism that the Fukushima lessons have been absorbed and that bagatellomania is still rabid. What saves human lives is ancestral knowledge and community preparedness, as demonstrated repeatedly. Efforts need to be focused in improving education worldwide in the simple steps they can take. We acknowledge the partial supports from the 7th FP (ASTARTE, Grant 603839), TUBITAK, TR (109Y387) and GSRT, GR (10TUR/1-50-1) projects.

  6. Experimental demonstration of passive acoustic imaging in the human skull cavity using CT-based aberration corrections.

    PubMed

    Jones, Ryan M; O'Reilly, Meaghan A; Hynynen, Kullervo

    2015-07-01

    Experimentally verify a previously described technique for performing passive acoustic imaging through an intact human skull using noninvasive, computed tomography (CT)-based aberration corrections Jones et al. [Phys. Med. Biol. 58, 4981-5005 (2013)]. A sparse hemispherical receiver array (30 cm diameter) consisting of 128 piezoceramic discs (2.5 mm diameter, 612 kHz center frequency) was used to passively listen through ex vivo human skullcaps (n = 4) to acoustic emissions from a narrow-band fixed source (1 mm diameter, 516 kHz center frequency) and from ultrasound-stimulated (5 cycle bursts, 1 Hz pulse repetition frequency, estimated in situ peak negative pressure 0.11-0.33 MPa, 306 kHz driving frequency) Definity™ microbubbles flowing through a thin-walled tube phantom. Initial in vivo feasibility testing of the method was performed. The performance of the method was assessed through comparisons to images generated without skull corrections, with invasive source-based corrections, and with water-path control images. For source locations at least 25 mm from the inner skull surface, the modified reconstruction algorithm successfully restored a single focus within the skull cavity at a location within 1.25 mm from the true position of the narrow-band source. The results obtained from imaging single bubbles are in good agreement with numerical simulations of point source emitters and the authors' previous experimental measurements using source-based skull corrections O'Reilly et al. [IEEE Trans. Biomed. Eng. 61, 1285-1294 (2014)]. In a rat model, microbubble activity was mapped through an intact human skull at pressure levels below and above the threshold for focused ultrasound-induced blood-brain barrier opening. During bursts that led to coherent bubble activity, the location of maximum intensity in images generated with CT-based skull corrections was found to deviate by less than 1 mm, on average, from the position obtained using source-based corrections. Taken together, these results demonstrate the feasibility of using the method to guide bubble-mediated ultrasound therapies in the brain. The technique may also have application in ultrasound-based cerebral angiography.

  7. Measurement of Soret and Fickian diffusion coefficients by orthogonal phase-shifting interferometry and its application to protein aqueous solutions

    NASA Astrophysics Data System (ADS)

    Torres, Juan F.; Komiya, Atsuki; Henry, Daniel; Maruyama, Shigenao

    2013-08-01

    We have developed a method to measure thermodiffusion and Fickian diffusion in transparent binary solutions. The measuring instrument consists of two orthogonally aligned phase-shifting interferometers coupled with a single rotating polarizer. This high-resolution interferometer, initially developed to measure isothermal diffusion coefficients in liquid systems [J. F. Torres, A. Komiya, E. Shoji, J. Okajima, and S. Maruyama, Opt. Lasers Eng. 50, 1287 (2012)], was modified to measure transient concentration profiles in binary solutions subject to a linear temperature gradient. A convectionless thermodiffusion field was created in a binary solution sample that is placed inside a Soret cell. This cell consists of a parallelepiped cavity with a horizontal cross-section area of 10 × 20 mm2, a variable height of 1-2 mm, and transparent lateral walls. The small height of the cell reduces the volume of the sample, shortens the measurement time, and increases the hydrodynamic stability of the system. An additional free diffusion experiment with the same optical apparatus provides the so-called contrast factors that relate the unwrapped phase and concentration gradients, i.e., the measurement technique is independent and robust. The Soret coefficient is determined from the concentration and temperature differences between the upper and lower boundaries measured by the interferometer and thermocouples, respectively. The Fickian diffusion coefficient is obtained by fitting a numerical solution to the experimental concentration profile. The method is validated through the measurement of thermodiffusion in the well-known liquid pairs of ethanol-water (ethanol 39.12 wt.%) and isobutylbenzene-dodecane (50.0 wt.%). The obtained coefficients agree with the literature values within 5.0%. Finally, the developed technique is applied to visualize biomolecular thermophoresis. Two protein aqueous solutions at 3 mg/ml were used as samples: aprotinin (6.5 kDa)-water and lysozyme (14.3 kDa)-water. It was found that the former protein molecules are thermophilic and the latter thermophobic. In contrast to previously reported methods, this technique is suitable for both short time and negative Soret coefficient measurements.

  8. The Effects of Hyperbaric Pressure on in vitro Neural Receptors.

    DTIC Science & Technology

    1984-06-01

    antibodies raised against this protein have led to the postulate that the neuromuscular disorder, myasthenia gravis , is an auto-immune disease involving... myasthenia gravis . Life Sci. 18:1031, 1976. 23. Drachman, D.B. Myasthenia gravis . New Eng. J. Med. 298:186, 1978. 24. Cohen, J.B. and Changeux, J.P. The

  9. The Effect of Microstructure on the Properties of High Strength Aluminum Alloys

    DTIC Science & Technology

    1980-02-01

    precracked samples were loaded with opposing bolts to constant crack opening displacement (COD) values. The notch with the precrack was sealed with Scotch tape ...Respectfully submitted: Edgar K. Starke, Jr. Principal Investigator Si Il I REFERENCES 1. P. C. Paris and F. Erdogan , J. Basic Eng., Vol. 85, 1963, p. 528

  10. 32 CFR 644.343 - Additional data for clearance with the committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Additional data for clearance with the committees. 644.343 Section 644.343 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... history of acquisition, development, and disposal, if not included in ENG Form 2187-R. Include official...

  11. 32 CFR 644.343 - Additional data for clearance with the committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Additional data for clearance with the committees. 644.343 Section 644.343 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... history of acquisition, development, and disposal, if not included in ENG Form 2187-R. Include official...

  12. 46 CFR 154.410 - Cargo tank sloshing loads.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Cargo tank sloshing loads. 154.410 Section 154.410... Containment Systems § 154.410 Cargo tank sloshing loads. (a) For the calculation required under § 154.406 (a... be specially approved by the Commandant (CG-ENG). (b) If the sloshing loads affect the cargo tank...

  13. Meeting the New College Composition II Course Goals through Original Research

    ERIC Educational Resources Information Center

    Tompkins, Patrick

    2007-01-01

    In a College Composition II (ENG 112) class offered during the spring of 2005 at John Tyler Community College (JTCC), the author implemented an information-literacy curriculum whose salient features include: students collaborated on a semester-long, original-research project. The Metro Richmond Supermarket Price Comparison provided a focused,…

  14. Extraction of Carbon Dioxide From Seawater by Ion Exchange Resin. Part 2. Using Strong Base Anion Exchange Resin

    DTIC Science & Technology

    2009-09-29

    and nitrogen compounds that are produced from the combustion of petroleum derived fossil fuel. In addition the process is advantageous in that it is...REFERENCES 1. Mohanasundaram, S. Renewable Power Generation-Utilising Thermal Energy From Oceans. Enviro . Sci. & Eng. 2007, 4, 35. 18 2. Avery

  15. Update on the Us Army’s Fuel Contamination Detection Efforts

    DTIC Science & Technology

    2011-04-04

    Dual Eng flameout Contaminated with water and particulate 14 2009 C-130 USAF Jet Fuel Contamination with Fatty Acid Methyl Ester ( FAME ) BioFuel 15 20...DRNEN. WARRGHTER FOCUSED. Summary of Incidents • US Air Force – 2 - T-37 Super Absorbent Polymer 1 C 130 FAME Fatty Methyl Ester

  16. A GIS BASED DECISION SUPPORT SYSTEM AND RESOURCE TOOL FOR USE ON STUDIES OF THE LAKE TEXOMA ECOSYSTEM

    EPA Science Inventory

    Investigations are underway at Lake Texoma, to develop decision support tools and information to evaluate the transport and attenuation of contaminants and stressors in a lake ecosystem, and link them to observable ecological effects. The U.S. EPA, USGS, U. S. Army Corps of Eng...

  17. Studies of Nonlinear Phenomena in Plasmas.

    DTIC Science & Technology

    1980-03-01

    Nonperiodic Oscillations of Langmuir Waves, UCLA Engr. Rpt. No. ENG- 7879 , Nov. 1978. .--- j, - :- -- ... . ___________ - - 8 V. PUBLICATIONS, REPORTS AND...OF CHAOTIC OSCILLATIONS ...... ............ 9 V. POINCARE MAPS ......... ...................... . 13 VI . CONCLUDING REMARKS...But the graphs of the Poincare maps in terms of some curve parameter are not readily obtainable. VI . CONCLUDING REMARKS The results of this study

  18. Campus-Wide Computing: Early Results Using Legion at the University of Virginia

    DTIC Science & Technology

    2006-01-01

    Bernard et al., “Primitives for Distributed Computing in a Heterogeneous Local Area Network Environ- ment”, IEEE Trans on Soft. Eng. vol. 15, no. 12...1994. [16] F. Ferstl, “CODINE Technical Overview,” Genias, April, 1993. [17] R. F. Freund and D. S. Cornwell , “Superconcurrency: A form of distributed

  19. 46 CFR 164.019-3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Guard-approved PFDs. Commandant means the Chief of the Lifesaving and Fire Safety Division, Office of Engineering and Design Standards, U.S. Coast Guard. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire... and III. 3 III. 4B IV (all Ring Buoys). 4BC IV (Buoyant Cushions). 4RB IV (Recreational Ring Buoys...

  20. 46 CFR 164.019-3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Guard-approved PFDs. Commandant means the Chief of the Lifesaving and Fire Safety Division, Office of Engineering and Design Standards, U.S. Coast Guard. Address: Commandant (CG-ENG-4), Attn: Lifesaving and Fire... and III. 3 III. 4B IV (all Ring Buoys). 4BC IV (Buoyant Cushions). 4RB IV (Recreational Ring Buoys...

  1. Organizational Perceptions of Telecommuting in the Private Sector

    ERIC Educational Resources Information Center

    Galusha, Repps J.

    2011-01-01

    The Internet has provided more organizations the opportunity to adopt telecommuting as a means to recruit and retain employees, boost productivity, and trim facility costs. This study expands on the work of a previous study by Hoang, Nickerson, Beckman, and Eng, in 2008 which found that private organizations, due to perceptions of organizational…

  2. Mechanics of Elevated Temperature Fatigue Damage in Fiber-Reinforced Ceramics

    DTIC Science & Technology

    1993-01-01

    Wang and Parvizi- Majidi 117] have measured the frictional shear stress in Nicalon"h(CAS-lI composites; shear stress ranged from 12.4±2.6 for fiber...Parvizi- Majidi . "Mechanical Behavior of NicaloniM Fiber-Reinforced Calcium-Aluminosilicate Matrix Composites," Ceram. Eng. Sci. Proc., 11 [9-101 1607

  3. [Problems of population and environment in Indonesia].

    PubMed

    Mantra, I B

    1984-12-01

    The relationship between demographic factors and the environment in Indonesia is examined. The author notes that environmental degradation is occurring primarily in Java, Bali, and Lombok and that it is related to the large number of people who are very poor, slow agricultural growth, and lack of nonagricultural employment opportunities. (summary in ENG)

  4. Radio Frequency Emitter Geolocation Using Cubesats

    DTIC Science & Technology

    2014-03-27

    CUBESATS Andrew J. Small, B.S.E.E. Captain, USAF Approved: //signed// Maj Marshall Haker , PhD (Chairman) //signed// Jonathan Black, PhD (Member) //signed...Cubesat, Direct Position Determination, Angle of Arrival, Time Difference of Arrival, Instantaneous Received Frequency U U U UU 101 Maj Marshall Haker (ENG) (937) 255-3636 x4603 marshall.haker@afit.edu

  5. 46 CFR 154.350 - Bilge and ballast systems in the cargo area.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., and insulation spaces must have a means of sounding the space or other means of detecting liquid leakage specially approved by the Commandant (CG-ENG). (b) Each hold and insulation space must have a bilge drainage system. (c) Interbarrier spaces must have an eductor or pump for removing liquid cargo...

  6. 46 CFR 154.350 - Bilge and ballast systems in the cargo area.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., and insulation spaces must have a means of sounding the space or other means of detecting liquid leakage specially approved by the Commandant (CG-ENG). (b) Each hold and insulation space must have a bilge drainage system. (c) Interbarrier spaces must have an eductor or pump for removing liquid cargo...

  7. 46 CFR 154.350 - Bilge and ballast systems in the cargo area.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., and insulation spaces must have a means of sounding the space or other means of detecting liquid leakage specially approved by the Commandant (CG-ENG). (b) Each hold and insulation space must have a bilge drainage system. (c) Interbarrier spaces must have an eductor or pump for removing liquid cargo...

  8. 76 FR 68332 - International Fisheries; Pacific Tuna Fisheries; Fishing Restrictions in the Eastern Pacific Ocean

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ...://www.iattc.org/ResolutionsActiveENG.htm . Changes to Tuna Conservation Measures for 2011-2013... fishing vessels that often leads to loss of data critical to weather forecasting, tsunami warnings, search... of Climate Observations at http://osmc.noaa.gov/Monitor/OSMC/OSMC.html , also provides information...

  9. 46 CFR 130.470 - Fire alarms.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... fire detector and control unit must be of a type specifically approved by the Commandant (CG-ENG). (b) No fire-alarm circuit for the engine room may contain a fire detector for any other space. (c) The number and placement of fire detectors must be approved by the cognizant OCMI. [CGD 82-004 and CGD 86-074...

  10. 46 CFR 130.470 - Fire alarms.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... fire detector and control unit must be of a type specifically approved by the Commandant (CG-ENG). (b) No fire-alarm circuit for the engine room may contain a fire detector for any other space. (c) The number and placement of fire detectors must be approved by the cognizant OCMI. [CGD 82-004 and CGD 86-074...

  11. 46 CFR 130.470 - Fire alarms.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... fire detector and control unit must be of a type specifically approved by the Commandant (CG-ENG). (b) No fire-alarm circuit for the engine room may contain a fire detector for any other space. (c) The number and placement of fire detectors must be approved by the cognizant OCMI. [CGD 82-004 and CGD 86-074...

  12. Processing of Thermotropic Liquid Crystalline Polymers and Their Blends

    DTIC Science & Technology

    1990-02-23

    Dziemianowicz, J. Romanski and W. Werber , Polym. Eng. Sci., 28(12), 785 (1988). 22. C. U. Ko and G. L. Wilkes, J. Appi. Polym. Sci., 37, 3063 (1989). 23. K...Virginia 22217-5000 NSTL, Mississippi 39529 Dr. Bernard Dauda 1 Naval Weapons Center Naval Weapons Support Center Attn: Dr. Ron Atkins Code UKC Chemistry

  13. 46 CFR 28.40 - Incorporation by reference.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Commandant (CG-ENG), Attn: Office of Design and Engineering Systems, U.S. Coast Guard Stop 7509, 2703 Martin..., PA 19428-2959. ASTM F 1321-92, Standard Guide for Conducting a Stability Test (Lightweight Survey and... Laboratories, Inc. (UL), 12 Laboratory Drive, Research Triangle Park, NC 27709-3995 UL 217-1985—Single and...

  14. 46 CFR 28.40 - Incorporation by reference.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Commandant (CG-ENG), Attn: Office of Design and Engineering Systems, U.S. Coast Guard Stop 7509, 2703 Martin..., PA 19428-2959. ASTM F 1321-92, Standard Guide for Conducting a Stability Test (Lightweight Survey and... Laboratories, Inc. (UL), 12 Laboratory Drive, Research Triangle Park, NC 27709-3995 UL 217-1985—Single and...

  15. [The use of census data to estimate levels of urbanization].

    PubMed

    Darwin, M; Tukiran

    1991-01-01

    Problems concerning changes in the definition of urbanization for demographic analysis are examined. "This article attempts to examine the problem by clarifying the definition of the concept and indicators of urban and urbanization and by making a longitudinal analysis of urbanization using the Indonesian 1920-1990 Census data." (SUMMARY IN ENG) excerpt

  16. 46 CFR 160.051-3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... requirements prescribed in subpart 160.151 for a SOLAS A or SOLAS B liferaft, respectively, except that the... means a liferaft that does not meet the all of the requirements prescribed in subpart 160.151 for a...-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop 7509, 2703 Martin Luther King...

  17. 46 CFR 160.051-3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... requirements prescribed in subpart 160.151 for a SOLAS A or SOLAS B liferaft, respectively, except that the... means a liferaft that does not meet the all of the requirements prescribed in subpart 160.151 for a...-ENG-4), Attn: Lifesaving and Fire Safety Division, U.S. Coast Guard Stop 7509, 2703 Martin Luther King...

  18. Navy-ASEE Summer Faculty Research Program. Navy-ASEE Sabbatical Leave Program.

    DTIC Science & Technology

    1994-09-01

    University Arnall Physical Therapy N. Arizona Univ. I Azimi-Sadjadi Elec. Eng. Colorado St. Univ. Baird Chem. Univ. of Alabama in Huntsville I Bandy Mech...provide the framework for the analysis of data in magneto -optics and on tunneling structures for a number of years. Dr. Bilal M. Ayyub Associate

  19. The Wetting Behavior of Imidazolium-Containing, Room-Temperature Molten Salt.

    DTIC Science & Technology

    1984-08-28

    America, Inc.), Celgard 2500 and 3501 polypropylene film (Celanese Corp.) with 45% porosity and 0.04-pm pore size, and reticulated vitreous carbon or...E. Matijevic, ed., Wiley-Interscience, New York, pp. 85-153 (1969). (9) A. M. Schwartz , "Capillarity: Theory and Practice," Ind. Eng. Chem., 61, 10

  20. Measurement of the ^235mU Production Cross Section Using a Critical Assembly*

    NASA Astrophysics Data System (ADS)

    Macri, Robert; Authier, Nicolas; Becker, John; Belier, Gilbert; Bond, Evelyn; Bredeweg, Todd; Glover, S.; Meot, Vincent; Rundberg, Robert; Vieira, David; Wilhelmy, Jerry

    2006-10-01

    Measurements of the creation and destruction cross sections for actinide nuclei constitute an important experimental effort in support of Stockpile Stewardship. In this talk I will give a progress report on the effort to measure the production cross section of the ^235mU isomer integrated over a fission neutron spectrum. This ongoing experiment is fielded at CEA in Valduc, France, taking advantage of the CALIBAN critical assembly. This effort is performed in collaboration with LANL, LLNL, Bruyeres le Chatel, and Valduc staff. This experiment utilizes a technique to measure internal conversion electrons from the ^235mU isomer with the French BIII detector (Bruyeres le Chatel), and involves a substantial chemistry effort (LANL) to prepare targets for irradiation and counting, as well as to remove fission fragments after irradiation. Experimental techniques will be discussed and preliminary data presented. *Work performed under the auspices of the U.S. Department of Energy by Los Alamos National Laboratory (W-7405-ENG-36) and Lawrence Livermore National Laboratory (W-7405-ENG-48), and CEA-DAM under CEA-DAM NNSA-DOE agreement.

  1. Complex permeability and permittivity spectra of percolated Fe50Co50/Cu granular composites

    NASA Astrophysics Data System (ADS)

    Massango, Herieta; Tsutaoka, Takanori; Kasagi, Teruhiro; Yamamoto, Shinichiro; Hatakeyama, Kenichi

    2017-11-01

    Complex permeability and permittivity spectra of Fe50Co50/Cu hybrid granular composite materials have been studied in the RF to microwave frequency range. At low Cu particle content, the Fe50Co50/Cu hybrid sample shows a metallic percolative property with the electrical conductivity value about 0.1 S/cm. However, the low frequency plasmonic (LFP) state with negative permittivity (ENG) spectrum was not observed. An abrupt increase of electrical conductivity takes place at 14 to 16 vol% Cu content where the conductivity becomes above 1.0 S/cm; the Fe50Co50/Cu composite possesses the LFP state with negative permittivity spectrum below a characteristic frequency. The complex permittivity spectra in the LFP state can be described by the Drude model. Magnetic permeability spectrum in the LFP state showed a broad frequency dispersion above 10 MHz; a small negative permeability (MNG) dispersion was observed from 2 to 10 GHz. Consequently, the double negative (DNG) electromagnetic property with MNG and ENG was realized in the microwave range for the Cu content of 26 and 30 vol%.

  2. Pulmonary arterial hypertension associated to systemic erythematous lupus: molecular characterization of 3 cases.

    PubMed

    Pousada, Guillermo; Lago-Docampo, Mauro; Baloira, Adolfo; Valverde, Diana

    2018-03-08

    Pulmonary arterial hypertension associated with systemic lupus erythematosus (PAH-SLE) is a rare disease with a low incidence rate. In this study, PAH related genes and genetic modifiers were characterised molecularly in patients with PAH-SLE. Three patients diagnosed with PAH-SLE and 100 control individuals were analysed after signing an informed consent. Two out of the three analysed patients with PAH-SLE were carriers of pathogenic mutations in the genes BMPR2 and ENG. After an in silico analysis, pathogenic mutations were searched for in control individuals and different databases, with negative results, and they were thus functionally analysed. The third patients only showed polymorphisms in the genes BMPR2, ACVRL1 and ENG. Several genetic variants and genetic modifiers were identified in the three analysed patients. These modifiers, along with the pathogenic mutations, could lead to a more severe clinical course in patients with PAH. We present, for the first time, patients with PAH-SLE carrying pathogenic mutations in the main genes related to PAH and alterations in the genetic modifiers. Copyright © 2018 Elsevier España, S.L.U. All rights reserved.

  3. Levels of serum-circulating angiogenic factors within 1 week prior to delivery are closely related to conditions of pregnant women with pre-eclampsia, gestational hypertension, and/or fetal growth restriction.

    PubMed

    Nanjo, Sakiko; Minami, Sawako; Mizoguchi, Mika; Yamamoto, Madoka; Yahata, Tamaki; Toujima, Saori; Shiro, Michihisa; Kobayashi, Aya; Muragaki, Yasuteru; Ino, Kazuhiko

    2017-12-01

    We aimed to investigate maternal serum angiogenic marker profiles within 1 week prior to delivery in cases of gestational hypertension (GH), pre-eclampsia (PE), and/or fetal growth restriction (FGR) with different clinical conditions. We enrolled 165 women with singleton pregnancy. The participants were classified based on three characteristics: (i) proteinuria (GH and PE); (ii) FGR (PE with FGR [PE + FGR], PE alone, and FGR alone); and (iii) onset (early onset PE [EO PE] and late-onset PE [LO PE]). All sera were obtained within 1 week prior to delivery, and soluble fms-like tyrosine kinase 1 (sFlt-1), soluble endoglin (sEng), and placental growth factor (PlGF) were measured with enzyme-linked immunosorbent assay. (i) In PE, a significantly increased sFlt-1, sEng, and sFlt-1 to PlGF ratio (sFlt-1/PlGF) and significantly decreased PlGF were observed compared with GH and Term control, whereas in GH, only sFlt-1/PlGF was significantly higher than Term control. (ii) In PE + FGR, similar changes were more markedly shown compared with PE alone. The FGR alone group exhibited similar tendencies as PE, although significant differences were found in PlGF and sEng levels. (iii) In EO PE, significant changes were observed in all factors compared with LO PE or Term control, while no significant change in PlGF levels was observed between LO PE and Term control. We demonstrated that the levels of circulating angiogenic factors just before delivery are correlated with the severity of hypertensive disorders of pregnancy and FGR. Profiling these specific markers may contribute to better understanding of the clinical conditions in individual patients and their pathogenesis. © 2017 Japan Society of Obstetrics and Gynecology.

  4. Physiologic Factors Influencing the Arterial-To-End-Tidal CO2 Difference and the Alveolar Dead Space Fraction in Spontaneously Breathing Anesthetised Horses.

    PubMed

    Mosing, Martina; Böhm, Stephan H; Rasis, Anthea; Hoosgood, Giselle; Auer, Ulrike; Tusman, Gerardo; Bettschart-Wolfensberger, Regula; Schramel, Johannes P

    2018-01-01

    The arterial to end-tidal CO 2 difference (P (a-ET) CO 2 ) and alveolar dead space fraction (VDalv frac  = P (a-ET) CO 2 /PaCO 2 ), are used to estimate Enghoff's "pulmonary dead space" (V/Q Eng ), a factor which is also influenced by venous admixture and other pulmonary perfusion abnormalities and thus is not just a measure of dead space as the name suggests. The aim of this experimental study was to evaluate which factors influence these CO 2 indices in anesthetized spontaneously breathing horses. Six healthy adult horses were anesthetized in dorsal recumbency breathing spontaneously for 3 h. Data to calculate the CO 2 indices (response variables) and dead space variables were measured every 30 min. Bohr's physiological and alveolar dead space variables, cardiac output (CO), mean pulmonary pressure (MPP), venous admixture [Formula: see text], airway dead space, tidal volume, oxygen consumption, and slope III of the volumetric capnogram were evaluated (explanatory variables). Univariate Pearson correlation was first explored for both CO 2 indices before V/Q Eng and the explanatory variables with rho were reported. Multiple linear regression analysis was performed on P (a-ET) CO 2 and VDalv frac assessing which explanatory variables best explained the variance in each response. The simplest, best-fit model was selected based on the maximum adjusted R 2 and smallest Mallow's p (C p ). The R 2 of the selected model, representing how much of the variance in the response could be explained by the selected variables, was reported. The highest correlation was found with the alveolar part of V/Q Eng to alveolar tidal volume ratio for both, P (a-ET) CO 2 ( r  = 0.899) and VDalv frac ( r  = 0.938). Venous admixture and CO best explained P (a-ET) CO 2 ( R 2  = 0.752; C p  = 4.372) and VDalv frac ( R 2  = 0.711; C p  = 9.915). Adding MPP (P (a-ET) CO 2 ) and airway dead space (VDalv frac ) to the models improved them only marginally. No "real" dead space variables from Bohr's equation contributed to the explanation of the variance of the two CO 2 indices. P (a-ET) CO 2 and VDalv frac were closely associated with the alveolar part of V/Q Eng and as such, were also influenced by variables representing a dysfunctional pulmonary perfusion. Neither P (a-ET) CO 2 nor VDalv frac should be considered pulmonary dead space, but used as global indices of V/Q mismatching under the described conditions.

  5. [Vaccination against viral hepatitis A and B in adults aged over 40 years--antibody persistence and immune memory].

    PubMed

    Chlibek, R; Smetana, J; Bostíková, V; Splino, M

    2011-09-01

    Primary vaccination with combined vaccine against viral hepatitis A (VHA) and viral hepatitis B (VHB) induces higher anti-hepatitis B surface (anti-HBs) antibody responses and similar anti-hepatitis A virus (anti-HAV) antibody responses in adults aged over 40 years in comparison with concomitant monovalent vaccines against VHA and VHB. Th e objectives were to assess, in a clinical study, persistence of anti-HAV and anti-HBs antibodies in adults aged over 40 years four years after primary VHA/VHB vaccination and antibody response following a booster dose of the vaccine. Five hundred and ninety-six subjects aged > 40 years were vaccinated with three doses of the combined VHA/VHB vaccine at Months 0, 1, 6 (HAB group) or with concomitant VHA and VHB vaccines at Months 0, 6 and 0, 1, 6 (ENG+HAV and HBVX+VAQ, respectively). Blood samples were collected one month following primary vaccination (Month 7) and then at one-year intervals for four years after the booster dose with the same vaccine as used for the primary vaccination. The anti-HBs and anti-HAV antibody levels were determined prior to the booster dose and at days 14 and 30 after the booster dose. At Month 7, > 97% of study subjects were seropositive for anti-HAV antibodies in all groups analyzed. Four years after primary vaccination, anti-HAV antibody seropositivity persisted in > 93% of study subjects, increasing to > 99% after the booster dose. At Month 7, the highest proportion of study subjects with anti-HBs antibody levels > or = 10 mIU/ml was found in the HAB group (91.7% versus 79.7% in the ENG+HAV group versus 71.0% in the HBVX+VAQ group). Four years after vaccination, anti-HBs antibody levels of 10 mIU/ml persisted in 57.1% of the HAB study subjects in comparison with 40.1% and 26.6% of the study subjects in the ENG+HAV and HBVX+VAQ groups, respectively. One month after the booster dose, anti-HBs antibody levels increased and antibody levels > or = 10 mIU/ml was achived in 95.2% of study subjects in the HAB group, 90.5% in the ENG+HAV group and 85.3% in the HBVX+VAQ group. In the adults aged over 40 years, an adequate anti-HAV antibody response persisted for at least four years after vaccination and was higher and more sustained in those who received the combined HAB vaccine. A strong antibody response to the booster dose indicative ofthe presence of immune memory was seen in all study groups.

  6. Computation of Temperature-Dependent Legendre Moments of a Double-Differential Elastic Cross Section

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arbanas, Goran; Dunn, Michael E; Larson, Nancy M

    2011-01-01

    A general expression for temperature-dependent Legendre moments of a double-differential elastic scattering cross section was derived by Ouisloumen and Sanchez [Nucl. Sci. Eng. 107, 189-200 (1991)]. Attempts to compute this expression are hindered by the three-fold nested integral, limiting their practical application to just the zeroth Legendre moment of an isotropic scattering. It is shown that the two innermost integrals could be evaluated analytically to all orders of Legendre moments, and for anisotropic scattering, by a recursive application of the integration by parts method. For this method to work, the anisotropic angular distribution in the center of mass is expressedmore » as an expansion in Legendre polynomials. The first several Legendre moments of elastic scattering of neutrons on U-238 are computed at T=1000 K at incoming energy 6.5 eV for isotropic scattering in the center of mass frame. Legendre moments of the anisotropic angular distribution given via Blatt-Biedenharn coefficients are computed at ~1 keV. The results are in agreement with those computed by the Monte Carlo method.« less

  7. Implicit continuum mechanics approach to heat conduction in granular materials

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Massoudi, M.; Mehrabadi, M.

    In this paper, we derive a properly frame-invariant implicit constitutive relationship for the heat flux vector for a granular medium (or a density-gradient-type fluid). The heat flux vector is commonly modeled by Fourier’s law of heat conduction, and for complex materials such as nonlinear fluids, porous media, or granular materials, the coefficient of thermal conductivity is generalized by assuming that it would depend on a host of material and kinematic parameters such as temperature, shear rate, porosity, concentration, etc. In this paper, we extend the approach of Massoudi [Massoudi, M. Math. Methods Appl. Sci. 2006, 29, 1585; Massoudi, M. Math.more » Methods Appl. Sci. 2006, 29, 1599], who provided explicit constitutive relations for the heat flux vector for flowing granular materials; in order to do so, we use the implicit scheme suggested by Fox [Fox, N. Int. J. Eng. Sci. 1969, 7, 437], who obtained implicit relations in thermoelasticity.« less

  8. An efficient method for unfolding kinetic pressure driven VISAR data

    DOE PAGES

    Mark Harry Hess; Peterson, Kyle; Harvey-Thompson, Adam James

    2015-08-18

    Velocity Interferometer System for Any Reflector (VISAR) [Barker and Hollenbach, J. Appl. Phys.43, 4669 (1972)] is a well-known diagnostic that is employed on many shock physics and pulsed-power experiments. With the VISAR diagnostic, the velocity on the surface of any metal flyer can be found. For most experiments employing VISAR, either a kinetic pressure [Grady, Mech. Mater.29, 181 (1998)] or a magnetic pressure [Lemkeet al., Intl J. Impact Eng.38, 480 (2011)] drives the motion of the flyer. Moreover, reliable prediction of the time-dependent pressure is often a critical component to understanding the physics of these experiments. Although VISAR can provide amore » precise measurement of a flyer’s surface velocity, the real challenge of this diagnostic implementation is using this velocity to unfold the time-dependent pressure. As a result, the purpose of this paper is to elucidate a new method for quickly and reliably unfolding VISAR data.« less

  9. A validated near-infrared spectroscopic method for methanol detection in biodiesel

    NASA Astrophysics Data System (ADS)

    Paul, Andrea; Bräuer, Bastian; Nieuwenkamp, Gerard; Ent, Hugo; Bremser, Wolfram

    2016-06-01

    Biodiesel quality control is a relevant issue as biodiesel properties influence diesel engine performance and integrity. Within the European metrology research program (EMRP) ENG09 project ‘Metrology for Biofuels’, an on-line/at-site suitable near-infrared spectroscopy (NIRS) method has been developed in parallel with an improved EN14110 headspace gas chromatography (GC) analysis method for methanol in biodiesel. Both methods have been optimized for a methanol content of 0.2 mass% as this represents the maximum limit of methanol content in FAME according to EN 14214:2009. The NIRS method is based on a mobile NIR spectrometer equipped with a fiber-optic coupled probe. Due to the high volatility of methanol, a tailored air-tight adaptor was constructed to prevent methanol evaporation during measurement. The methanol content of biodiesel was determined from evaluation of NIRS spectra by partial least squares regression (PLS). Both GC analysis and NIRS exhibited a significant dependence on biodiesel feedstock. The NIRS method is applicable to a content range of 0.1% (m/m) to 0.4% (m/m) of methanol with uncertainties at around 6% relative for the different feedstocks. A direct comparison of headspace GC and NIRS for samples of FAMEs yielded that the results of both methods are fully compatible within their stated uncertainties.

  10. Assessing the Impact of Academic Support: University of the Witwatersrand First-Year Engineering

    ERIC Educational Resources Information Center

    Onsongo, W. M.

    2006-01-01

    On average the B.Sc. (Eng.) degree programmes in South Africa universities graduate about 50-60 per cent of the students admitted. Generally, the highest dropout occurs in the first year of registration. This article reviews admission and graduation statistics at the University of the Witwatersrand (Wits) and assesses the impact of recent academic…

  11. Ground Based Synoptic Instrumentation for Solar Observations (Postprint)

    DTIC Science & Technology

    2012-03-05

    vector spectropolarimetry in FeI 630.15-630.25 nm wavelength range, and line-of-sight (circular) polarimetry in Fe I 6301.5-6302.5 Å, and Ca II 8542 Å...Stokes vector polarimetry . Opt. Eng. 38, 1402-1408, 1999. [22] C. U. Keller, J. W. Harvey, M. S. Giampapa, “SOLIS: an innovative suite of synoptic

  12. Experimental Study of Turbulent Mixing and Selectivity of Competing Reactions

    DTIC Science & Technology

    1988-07-01

    polymerization reactors ( Van der Molen et al., 1982). MIixing is also recognized as a key factor affecting overall performance of a combustor--both in terms...Eng. Sci., 28, 413 (1973). Van der Molen , T. J., A. Koenen, H. H. J. Oosterwijk, and H. Th. Van der Bend. "Effect of Process Conditions on Light-Off

  13. JPRS Report, Science & Technology China

    DTIC Science & Technology

    1989-02-02

    40091007b Beijing WEISHENGWU XUEBAO [ACTA MICROBIOLOGICA SINICA] in Chinese Vol 28 No 3, Sep 88 pp 257- 264 [English abstract of article by Gong Jianhua...G.H., KAPL-M-SMS-31, 1956, pp 4-6. 4. Caldwell, C.S., WAPD -CP-1030, 1956, pp 1-5. 5. Himmelblau, D.M., et al., J. CHEM. ENG. DATA, Vol 5 No 1, 1

  14. The Feasibility and Current Estimated Capital Costs of Producing Jet Fuel at Sea Using Carbon Dioxide and Hydrogen

    DTIC Science & Technology

    2010-09-29

    process is CO2 neutral and also eliminates the emission of sulfur and nitrogen compounds that are produced from the combustion of petroleum derived...Mohanasundaram, S. Renewable Power Generation-Utilising Thermal Energy from Oceans. Enviro . Sci. & Eng. 2007, 4, 35. 13. Avery, W. H.; Wu, C. Renewable

  15. The Feasibility and Current Estimated Capital Costs of Producing Jet Fuel at Sea Using Carbon Dioxide and Hydrogen

    DTIC Science & Technology

    2010-09-29

    emission of sulfur and nitrogen compounds that are produced from the combustion of petroleum derived fossil fuel. 2.0 INTRODUCTION A costlbenefit and...Thermal Energy from Oceans. Enviro . Sci. & Eng. 2007,4,35. 13. Avery, W. H.; Wu, C. Renewable Energy From The Ocean; Oxford University Press: New York

  16. [An essay on Quebec's demographic development from 1534 to 2034].

    PubMed

    Charbonneau, H

    1984-04-01

    A general review of the development of the population of Quebec since 1534 is presented in the form of separate summaries for each 50-year period. Topics discussed include sources of data, estimates of the North American Indian population, and estimates of immigration. Some consideration is given to projections to the year 2034. (summary in ENG, SPA)

  17. The MCQ in the primary FRCS(Eng).

    PubMed Central

    Lumley, J. S.; Browne, P. D.; Elcock, N. J.

    1984-01-01

    Analysis of the primary fellowship results showed that on average candidates were scoring a significantly higher mark in the MCQ than in the essay or viva. The level of MCQ marking has therefore been reset to the standards of the other parts of the examination. The need for continually monitoring the results of all examinations is emphasised. PMID:6508170

  18. [The demographic and occupational characteristics of Italian migrants to Argentina, 1880-1930].

    PubMed

    Cacopardo, M C; Moreno, J L

    1984-09-01

    "This essay studies...the demographic and socio-professional characteristics of the Italian emigrants in Argentina during the period 1880-1930. Besides a reconstruction of the demographic variables (age, sex, mortality, and fertility) in the historical series, the essay also depicts the professional profile of the Italians in Argentina...." (summary in ENG, FRE) excerpt

  19. [[Malthus on oscillation and the first Essay on Population

    PubMed

    Nakanishi, Y

    1988-05-01

    Aspects of Malthus's theory of population are considered. The focus is on the theory of cycles, by which increases in population are periodically checked by increases in misery and vice due to overpopulation. The author attempts to show how the concept of population cycles is basic to much of Malthus's thinking on population. (SUMMARY IN ENG)

  20. The MCQ in the primary FRCS(Eng).

    PubMed

    Lumley, J S; Browne, P D; Elcock, N J

    1984-11-01

    Analysis of the primary fellowship results showed that on average candidates were scoring a significantly higher mark in the MCQ than in the essay or viva. The level of MCQ marking has therefore been reset to the standards of the other parts of the examination. The need for continually monitoring the results of all examinations is emphasised.

  1. Survivable Propagation.

    DTIC Science & Technology

    1984-11-01

    Electromagnetic Radiation, -Meteor Burst Propagation , 20 14 Electromagnetic Transients Tranverse Electric,, A- .(Se2ee Rverse) 1S. ABSTRACT Continue on mrverm if...Camn1w1caft.Ofl and IntelZigence (C3 1) act Lvitie.. Technco2 and eng.LnevLxing 6uPPo~t wi~thin wteaz oj techniZcat competence i6s ptov-𔃾ed to ESV Ptrogtam

  2. ARC Accomplishments and Collaborations Pursuing Challenges with Vision and Focus

    DTIC Science & Technology

    2010-05-10

    Navistar Defense LLC – Dr. Joe Lin, Eaton – Dr. Young Jae Kim, GM Hybrid Powertrain Eng. – Dr. Bin Wu, Mercedes - Benz Hybrid LLC – Dr. Vasilios Tsourapas...Fellows: 3 SAE, 4 ASME, 1 AAAS,1 IACM, 3 IEEE • 8 external Research and Educational Awards • 8 University Awards • 2 Young Scientists/Young Innovator

  3. An Abstract Data Model for the IDEF0 Graphical Analysis Language

    DTIC Science & Technology

    1990-01-11

    whatever level was necessary to ensure an unambiguous interpretation of the system require- ments. Marca and McGowan have written an excellent book which...December 1987. AFIT/GE/ENG/87D-28. [7] MARCA , D. A., AND McGOWAN, C. L. SADT Structured Analysis and Design Technique. McGraw- Hill Book Company, 1988. [8

  4. [The creation of the informal sector in urban areas].

    PubMed

    Papayungan, M M

    1984-12-01

    The development of the informal sector of the economy in urban areas of Indonesia is analyzed. The author notes that this sector is dominated by high rates of migration from rural areas, limited employment opportunities for the unskilled in the modern sector, and a demand for low-priced services and products from the informal sector. (summary in ENG)

  5. [Background and characteristics of migration to urban areas in Java].

    PubMed

    Kawamoto, I

    1985-06-01

    A review of urbanization trends in Java, Indonesia, is presented, with the focus on the background and characteristics of migrants to urban areas. Comparisons are made between the characteristics of laborers in the informal sector (housemaids) and those of factory workers, and between migrants from rural areas and those from other urban areas. (summary in ENG)

  6. Functional Assessment of Skeletal Muscle Regeneration Utilizing Homologous Extracellular Matrix as Scaffolding

    DTIC Science & Technology

    2010-01-01

    as a biologic scaffold material. Biomaterials 28, 3587, 2007. 24. Conconi, M.T., De Coppi, P., Bellini, S., Zara , G., Sabatti, M., Marzaro, M., Zanon...full-thickness ab- dominal wall defects. Tissue Eng 12, 1929, 2006. 26. Gamba, P.G., Conconi, M.T., Lo Piccolo, R., Zara , G., Spi- nazzi, R., and

  7. Navigation with Limited Prior Information Using Time Difference of Arrival Measurements from Signals of Opportunity

    DTIC Science & Technology

    2010-12-01

    radiolocation in CDMA cellular systems”. IEEE Communications Magazine, 36(4):38–45, April 1998. 5. Code of Federal Regulations. “AM Broadcast Stations... DS /ENG/05-02. [Online]. Available at http://handle.dtic.mil/100.2/ADA442340. 11. Foy, Wade H. “Position-Location Solutions by Taylor-Series Estimation

  8. The Electroplastic Effect in Metals.

    DTIC Science & Technology

    1984-05-11

    the pinch effect. The differ- oulses (%&0A/mm2 for ^-50iis duration) on the flow ence Acp-Anp (Fig. 4r) should then consist prima - * stress of a number...Silveira, R. A. F. 0. Fortes and W. Rvzhkov, Dokl. Akad. Nauk. SSSR 243 330-333 A. Mannheimer, 5th Congr. Brasileiro Eng. (1978). Ciencia Materias (Dec. 1982

  9. Facebook as a Learning-Management System in Developmental Writing

    ERIC Educational Resources Information Center

    Ingalls, Amy L.

    2017-01-01

    The purpose of this study was to assess whether Facebook (FB), as an LMS (Learning Management System) may be used in a developmental writing course, may build a community of learners in ENG*K012, and may enhance the presence of a supportive shared community to build confidence in students' writing and/or sharing their writing. An additional…

  10. [Mortality, morbidity, and the status of women].

    PubMed

    Caselli, G; Egidi, V

    1985-01-01

    Recent literature on the relationships between the health of women and living and working conditions is critically reviewed. Several studies have discussed the associations between morbidity and mortality of women in developed countries and such variables as work, education, marital status, and socioeconomic class. The limitations and advantages of various types of analysis are considered. (summary in ENG, FRE)

  11. The Process of Updating Engineering Management Science in an Australian Regional University Excellence in Developing E-Learning

    ERIC Educational Resources Information Center

    Ku, H.; Fulcher, R.

    2007-01-01

    The aim of the current paper is to share the processes in revising the courseware of the course of "Engineering Management Science" coded as ENG4004, in the Bachelor of Engineering (Mechanical, Mechatronics, Electrical and Electronic, Computer Systems, Instrumentation and Control), Bachelor of Engineering Technology (Mechanical, Building…

  12. Toward Automating Web Protocol Configuration for a Programmable Logic Controller Emulator

    DTIC Science & Technology

    2014-06-19

    Security Risks for Industrial Control Systems ,” VDE 2004 Congress, Berlin, Germany, October 2004, pp. 1-7. [Cis12] Cisco, NetFlow Configuration Guide...Date 29 May 2014 Date AFIT-ENG-T-14-J-4 Abstract Industrial Control Systems (ICS) remain vulnerable through attack vectors that exist within programmable...5 2.2 Industrial Control Systems

  13. Modeling and Control of State-Affine Probabilistic Systems for Atomic-Scale Dynamics

    DTIC Science & Technology

    2007-06-01

    Analysis for Nonlinear Systems. New York: Spring -Verlag, 1987. [5] M. Itoh, "Atomic-scale homoepitaxial growth simulations of reconstructed III-V surfaces...Ridge, NJ; 1995. -- SSC function of the Node 182 [2] M. K. Weldon , K. T. Queeney, J. Eng Jr., K. Raghavachari, and Y. J. Chabal, "The surface science

  14. [Population trends in Albania].

    PubMed

    Sivignon, M

    1983-01-01

    Recent demographic trends in Albania are reviewed. The author notes that rapid population growth persists due to continuing fertility, although the fertility rate has begun to decline during the past 20 years. Controls placed on internal migration have succeeded in restricting the growth of the urban population and have contributed to the sustained growth of the population in rural areas. (summary in ENG)

  15. Publisher Correction: Eternal blood vessels

    NASA Astrophysics Data System (ADS)

    Hindson, Jordan

    2018-05-01

    This article was originally published with an incorrect reference for the original article. The reference has been amended. Please see the correct reference below. Qiu, Y. et al. Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0224-z (2018)

  16. [International demographic developments in 1991 and 1992].

    PubMed

    Zakee, R

    1992-09-01

    Patterns in international migration in Europe for 1991 and 1992 are analyzed. Consideration is given to migration within Europe and from outside Europe to the continent. The effects of recent political changes in Eastern Europe and Yugoslavia on asylum applications for the Netherlands are also discussed. Some data on population change in Europe are also presented. (SUMMARY IN ENG)

  17. 32 CFR 644.380 - Restoration of lands made available by other Government agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of restoration costs. ENG Form 1440-R, Cost of Restoration, appropriately modified, will be used for the preparation of an estimate of cost of restoration, or salvage or market value, for the purpose of determining the cost of restoration. (d) Payments for, or in lieu of restoration—(1) Work Performed by the...

  18. Transcriptional Noise and Somatic Mutations in the Aging Pancreas.

    PubMed

    Swisa, Avital; Kaestner, Klaus H; Dor, Yuval

    2017-12-05

    The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations. Copyright © 2017. Published by Elsevier Inc.

  19. The Key Political Decisions of the Military Government in Turkey, September 1980-November 1983 and the Impact on Those Decisions.

    DTIC Science & Technology

    1985-05-01

    I-would argue that there is a relevant application of Professor Giovanni Sartoris theory of party systems to the Turkish case, especially in the 1979...1980 time frame. G. Sartori , Parties and Party Systems A Framework for Analysis (Cambridge Eng: Cambridge University Press, 1976). 7

  20. Empirical Analysis of Optical Attenuator Performance in Quantum Key Distribution Systems Using a Particle Model

    DTIC Science & Technology

    2012-03-01

    EMPIRICAL ANALYSIS OF OPTICAL ATTENUATOR PERFORMANCE IN QUANTUM KEY DISTRIBUTION SYSTEMS USING A...DISTRIBUTION IS UNLIMITED AFIT/GCS/ENG/12-01 EMPIRICAL ANALYSIS OF OPTICAL ATTENUATOR PERFORMANCE IN QUANTUM KEY DISTRIBUTION SYSTEMS USING ...challenging as the complexity of actual implementation specifics are considered. Two components common to most quantum key distribution

Some links on this page may take you to non-federal websites. Their policies may differ from this site.
Top