2005 AACC Convention Highlights

ERIC Educational Resources Information Center

Community College Journal, 2005

2005-01-01

More than 2,500 community college professionals participated in the 85th annual meeting of the American Association of Community Colleges in Boston, Massachusetts, April 9-12. Attendees took part in numerous workshops, forums, sessions, and roundtables and were witness to special presentations from Martin Luther King III, Senator Edward Kennedy,…

MANUAL FOR THE GENERAL APTITUDE TEST BATTERY. SECTION II, NORMS, OCCUPATIONAL APTITUDE PATTERN STRUCTURE.

ERIC Educational Resources Information Center

Bureau of Employment Security (DOL), Washington, DC.

THE NINE APTITUDES MEASURED BY THE GENERAL APTITUDE TEST BATTERY ARE INTELLIGENCE, VERBAL APTITUDE, NUMERICAL APTITUDE, SPATIAL APTITUDE, FORM PERCEPTION, CLERICAL PERCEPTION, MOTOR COORDINATION, FINGER DEXTERITY, AND MANUAL DEXTERITY. THIS MANUAL PRESENTS (1) PERCENTILE EQUIVALENTS OF APTITUDE OR STANDARD SCORES FOR ADULTS, 10TH GRADERS, AND 9TH…

Natural gamma-radiation in the Aeolian volcanic arc.

PubMed

Chiozzi, P; Pasquale, V; Verdoya, M; Minato, S

2001-11-01

Pulse-height distributions of gamma-rays, obtained with a field NaI(Tl) scintillation spectrometer in numerous sites of the Lipari and Vulcano islands (Aeolian volcanic arc, Italy), were measured to determine the U, Th and K concentrations of the bedrock and the relative values of the air absorbed dose rate. U is spatially related to both Th and K and the Th/U ratio is on average 3.1-3.5. The magmatic evolution is reflected by the concentration of the three radioelements, as they are more abundant within the more felsic units of the volcanic series. The higher values of U (15.7-20.0 ppm) coincide with higher Th (48.3-65.9 ppm) and K (4.9-6.1%) concentrations associated with rhyolitic rocks of the third cycle (< 50 ky). The air absorbed dose rate varies from 20 to 470 nGy h(-1). The highest values (> 350 nGy h(-1)) are observed on outcrops of rhyolitic obsidian lava flows. The cosmic-ray contribution is also evaluated to estimate the total background radiation dose rate.

Regrouping: organized activity involvement and social adjustment across the transition to high school.

PubMed

Bohnert, Amy M; Aikins, Julie Wargo; Arola, Nicole T

2013-01-01

Although organized activities (OAs) have been established as important contexts of development, limited work has examined the role of OAs across the high school transition in buffering adolescents' social adjustment by providing opportunities for visibility and peer affiliation. The transition to high school is characterized by numerous changes and OAs may provide an important setting for establishing and maintaining peer relationships during this tumultuous time. This study included 151 8th grade U.S. students (58% male) who were assessed across the transition to high school (spring of 8th and 9th grade). Continuous involvement in academic activities across the transition and becoming involved (i.e., initiation) in community/service activities following the transition was associated with fewer depressive symptoms in the spring of 9th grade. Continuous involvement in sports and initiation of academic activities was associated with having more friendships. In addition, links between OAs and loneliness were only evident among females. There appear to be significant social benefits for OA involvement. Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company.

A time-space domain stereo finite difference method for 3D scalar wave propagation

NASA Astrophysics Data System (ADS)

Chen, Yushu; Yang, Guangwen; Ma, Xiao; He, Conghui; Song, Guojie

2016-11-01

The time-space domain finite difference methods reduce numerical dispersion effectively by minimizing the error in the joint time-space domain. However, their interpolating coefficients are related with the Courant numbers, leading to significantly extra time costs for loading the coefficients consecutively according to velocity in heterogeneous models. In the present study, we develop a time-space domain stereo finite difference (TSSFD) method for 3D scalar wave equation. The method propagates both the displacements and their gradients simultaneously to keep more information of the wavefields, and minimizes the maximum phase velocity error directly using constant interpolation coefficients for different Courant numbers. We obtain the optimal constant coefficients by combining the truncated Taylor series approximation and the time-space domain optimization, and adjust the coefficients to improve the stability condition. Subsequent investigation shows that the TSSFD can suppress numerical dispersion effectively with high computational efficiency. The maximum phase velocity error of the TSSFD is just 3.09% even with only 2 sampling points per minimum wavelength when the Courant number is 0.4. Numerical experiments show that to generate wavefields with no visible numerical dispersion, the computational efficiency of the TSSFD is 576.9%, 193.5%, 699.0%, and 191.6% of those of the 4th-order and 8th-order Lax-Wendroff correction (LWC) method, the 4th-order staggered grid method (SG), and the 8th-order optimal finite difference method (OFD), respectively. Meanwhile, the TSSFD is compatible to the unsplit convolutional perfectly matched layer (CPML) boundary condition for absorbing artificial boundaries. The efficiency and capability to handle complex velocity models make it an attractive tool in imaging methods such as acoustic reverse time migration (RTM).

Vertical Jump and Leg Power Normative Data for Colombian Schoolchildren Aged 9-17.9 Years: The FUPRECOL Study.

PubMed

Ramírez-Vélez, Robinson; Correa-Bautista, Jorge E; Lobelo, Felipe; Cadore, Eduardo L; Alonso-Martinez, Alicia M; Izquierdo, Mikel

2017-04-01

Ramírez-Vélez, R, Correa-Bautista, JE, Lobelo, F, Cadore, EL, Alonso-Martinez, AM, and Izquierdo, M. Vertical jump and leg power normative data for Colombian schoolchildren aged 9-17.9 years: the FUPRECOL study. J Strength Cond Res 31(4): 990-998, 2017-The aims of the present study were to generate normative vertical jump height and predicted peak power (Ppeak) data for 9- to 17.9-year-olds and to investigate between-sex and age group differences in these measures. This was a cross-sectional study of 7,614 healthy schoolchildren (boys n = 3,258 and girls n = 4,356, mean [SD] age 12.8 [2.3] years). Each participant performed 2 countermovement jumps; jump height was calculated using a Takei 5414 Jump-DF Digital Vertical (Takei Scientific Instruments Co., Ltd.). The highest jump was used for analysis and in the calculation of predicted Ppeak. Centile smoothed curves, percentiles, and tables for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles were calculated using Cole's LMS (L [curve Box-Cox], M [curve median], and S [curve coefficient of variation]) method. The 2-way analysis of variance tests showed that maximum jump height (in centimeters) and predicted Ppeak (in watts) were higher in boys than in girls (p < 0.01). Post hoc analyses within sexes showed yearly increases in jump height and Ppeak in all ages. In boys, the maximum jump height and predicted Ppeak 50th percentile ranged from 24.0 to 38.0 cm and from 845.5 to 3061.6 W, respectively. In girls, the 50th percentile for jump height ranged from 22.3 to 27.0 cm, and the predicted Ppeak was 710.1-2036.4 W. For girls, jump height increased yearly from 9 to 17.9 years old. Our results provide, for the first time, sex- and age-specific vertical jump height and predicted Ppeak reference standards for Colombian schoolchildren aged 9-17.9 years.

A Study of Anatolian High Schools' 9th Grade English Language Curriculum in Relation to the CEFR

ERIC Educational Resources Information Center

Zorba, M. Galip; Arikan, Arda

2016-01-01

The aim of this study is to understand the main principles of the CEFR and to what extent Anatolian High Schools' 9th grade EFL curriculum meet the principles advocated in that document. Hence, document analysis was used as a method to seek answers to the research questions set by a comparative analysis of the CEFR and Anatolian High Schools'…

Toll like Receptor 2 engagement on CD4+ T cells promotes TH9 differentiation and function.

PubMed

Karim, Ahmad Faisal; Reba, Scott M; Li, Qing; Boom, W Henry; Rojas, Roxana E

2017-09-01

We have recently demonstrated that mycobacterial ligands engage Toll like receptor 2 (TLR2) on CD4 + T cells and up-regulate T-cell receptor (TCR) triggered Th1 responses in vitro and in vivo. To better understand the role of T-cell expressed TLR2 on CD4 + T-cell differentiation and function, we conducted a gene expression analysis of murine naïve CD4 + T-cells stimulated in the presence or absence of TLR2 co-stimulation. Unexpectedly, naïve CD4 + T-cells co-stimulated via TLR2 showed a significant up-regulation of Il9 mRNA compared to cells co-stimulated via CD28. Under TH9 differentiation, we observed up-regulation of TH9 differentiation, evidenced by increases in both percent of IL-9 secreting cells and IL-9 in culture supernatants in the presence of TLR2 agonist both in polyclonal and Ag85B cognate peptide specific stimulations. Under non-polarizing conditions, TLR2 engagement on CD4 + T-cells had minimal effect on IL-9 secretion and TH9 differentiation, likely due to a prominent effect of TLR2 signaling on IFN-γ secretion and TH1 differentiation. We also report that, TLR2 signaling in CD4 + T cells increased expression of transcription factors BATF and PU.1, known to positively regulate TH9 differentiation. These results reveal a novel role of T-cell expressed TLR2 in enhancing the differentiation and function of TH9 T cells. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The role of schoolmates' smoking and non-smoking in adolescents' smoking transitions: a longitudinal study.

PubMed

Bricker, Jonathan B; Andersen, M Robyn; Rajan, K Bharat; Sarason, Irwin G; Peterson, Arthur V

2007-10-01

The first longitudinal investigation of the extent to which same-age and older schoolmates' smoking and non-smoking are associated with adolescents' smoking transitions during three grade intervals. Same-age and older schoolmates' smoking and non-smoking were assessed when adolescents were at grades 5 (age 10), 7 (age 12) and 9 (age 14). Adolescents' smoking transitions were assessed at three grade intervals: 5th-7th (age 10-12), 7th-9th (age 12-14) and 9th-12th (age 14-17). Forty Washington State school districts. Smoking questionnaire data were gathered on a cohort of adolescents (n = 4354 for same-age schoolmate analysis; n = 1833 for older schoolmate analysis) that was 49% female and 91% Caucasian. No significant evidence that same-age schoolmates' smoking or non-smoking was associated with any of the adolescent smoking transitions at any of the three grade intervals. In contrast, the probability that each older schoolmate's smoking was associated with the adolescent making the transition to trying smoking was 1% (95% CI: 0.4%, 1.5%) and with the transition from trying to monthly smoking was also 1% (95% CI: 0.2%, 2.0%) during the 7th-9th grade (age 12-14) interval. Moreover, each older schoolmate's non-smoking was associated with a 1.001-1.006 (all P < 0.05) relative risk of an adolescent not trying smoking or escalating from trying to monthly smoking at several grade intervals. Interventions should perhaps focus on the influence of both smoking and non-smoking older schoolmates during late childhood and early adolescence.

Nostalgic for What? The Epidemic of Images of the Mid 20th Century Classroom in American Media Culture and What it Means

ERIC Educational Resources Information Center

Otto, Stacy

2005-01-01

Within this paper the author examines the current nostalgia for a never-present past through critical analysis of images of the mid 20th century American classroom in media culture. The author uses theories of nostalgia and the history of the photographic image to trouble the numerous equity issues surrounding the unchallenged canonization of the…

Department of Defense Weapon System Acquisition Policy: A System Dynamics Model and Analysis.

DTIC Science & Technology

1982-09-01

dimensionless) PRPRD = Perceived Pressure for R&D (dimensionless) PU - Programs in Progress (programs) RPRD - Raw Pressure for R&D (dimensionless) TDPP - Time...ECAP) TH9 Pressure Ra Pressure_.- for Acquisition ( TDPP ) TH25 4for Acquisition (DPFAO) TH22D (DPPFAO) TH21 US Intelligence \\ - 7 Delay Time / efense...DIBP, DPPFAQ. K) TH22 A CPPFAG.K=DLINF3(RPFAG.KTCPP) TH23 A CPFAQ.K=MAX (DIBPCPPFAQ.K) TH24 C TDPP =12 TH25 C TCPP-24 TH26 CPFAQ Congressional Pressure

Relationship of intentional self-harm using sharp objects with depressive and dissociative tendencies in pre-adolescence-adolescence.

PubMed

Sho, Noriko; Oiji, Arata; Konno, Chizue; Toyohara, Koji; Minami, Tatsuya; Arai, Takashi; Seike, Yoji

2009-06-01

The objectives of the present study were to (i) evaluate the prevalence of children and adolescents who have engaged in intentional self-harm using a sharp object; and (ii) investigate the relationship between self-harm with sharp objects and depressive tendencies or dissociative tendencies. A total of 1938 students in grades 5-12 in Yokohama, Japan, were enrolled, and they completed anonymous self-report questionnaires including a question about intentional self-harm with a sharp object, the Depression Self-Rating Scale for Children (DSRSC) and the Adolescent Dissociative Experiences Scale (A-DES). The prevalence of self-harm using sharp object was 5.4% among male 5th-6th graders, 4.0% among female 5th-6th graders, 5.3% among male 7th-9th graders, 15.1% among female 7th-9th graders, 6.6% among male 10th-12th graders, and 9.6% among female 10th-12th graders. Categorical regression analysis showed that a small amount of variance in self-harm by sharp object was explained by DSRSC and A-DES scores. Self-harm with a sharp object was prevalent among pre-adolescents and adolescents and was associated with depressive and dissociative tendencies.

What Makes a Mathematical Task Interesting?

ERIC Educational Resources Information Center

Nyman, Rimma

2016-01-01

The study addresses the question of what makes a mathematical task interesting to the 9th year students. Semi-structured interviews were carried out with 15 students of purposive selection of the 9th year. The students were asked to recall a task they found interesting and engaging during the past three years. An analysis of the tasks was made…

Effectiveness of Percutaneous Celiac Plexus Ablation in the Treatment of Severe Cancer Pain in Upper Abdomen and Evaluation of Health Economics.

PubMed

Cao, Jun; He, Yang; Liu, Hongqiang; Wang, Saibo; Zhao, Baocheng; Zheng, Xiaohui; Yang, Kai; Xie, Donghao

2017-03-01

To compare the effectiveness, adverse effects, and cost-effectiveness of percutaneous neurolytic celiac plexus block (NCPB) versus traditional medication strategies for the treatment of patients with advanced cancer having severe upper abdominal cancer pain. This retrospective study included 81 patients with advanced upper abdominal cancer admitted to The Sixth People's Hospital Affiliated to Shanghai Jiaotong University between January 2013 and July 2014. The patients were divided into percutaneous NCPB (treatment) and medication for pain (control) groups. The outcomes were measured in terms of Numeric Rating Scale (NRS) score and Karnofsky Performance Status (KPS) score before treatment and on the 3rd, 7th, 14th, and 28th days posttreatment. The effectiveness and cost-effectiveness of the therapy were assessed using analysis of the health economics. The improvements in NRS score (1.42 ± 1.09 vs 4.03 ± 0.96, P < .01) and KPS score (65.55 ± 9.09 vs 63.03 ± 8.961, P < .01) in the treatment group were significantly superior compared to the control group on the 7th day of treatment, followed by no significant difference between the 2 groups on the 14th and the 28th day of treatment. Health economics evaluation revealed that the medicine-specific costs and total health care costs were significantly reduced in the treatment group compared to the control group ( P < .05), but no significant differences between the 2 groups ( P > .05) were seen in the costs of hospitalization, examinations, and treatment. The percutaneous NCPB method shows promising results and better cost-effectiveness for treating patients with advanced cancer having severe upper abdominal pain.

Normative Reference of Standing Long Jump for Colombian Schoolchildren Aged 9-17.9 Years: The FUPRECOL Study.

PubMed

Ramírez-Vélez, Robinson; Martínez, Martin; Correa-Bautista, Jorge E; Lobelo, Felipe; Izquierdo, Mikel; Rodríguez-Rodríguez, Fernando; Cristi-Montero, Carlos

2017-08-01

Ramírez-Vélez, R, Martínez, M, Correa-Bautista, JE, Lobelo, F, Izquierdo, M, Rodríguez-Rodríguez, F, and Cristi-Montero, C. Normative reference of standing long jump for Colombian schoolchildren aged 9-17.9 years: The FUPRECOL study. J Strength Cond Res 31(8): 2083-2090, 2017-The purpose of this study was to generate normative values for the standing long jump (SLJ) test in 9- to 17.9-year olds and to investigate sex and age-group differences. The sample comprised 8,034 healthy Colombian schoolchildren [boys n = 3,488 and girls n = 4,546; mean (SD) age 12.8 (±2.3) years old]. Each participant performed two SLJ. Centile smoothed curves, percentile, and tables for the third, 10th, 25th, 50th, 75th, 90th, and 97th percentiles were calculated using Cole's Lambda-Mu-Sigma method. The 2-way analysis of variance tests and Cohen's d showed that the maximum SLJ (centimeter) was higher in boys than in girls across age groups (p < 0.01), reaching the peak at 13 years. Posthoc analyses within the sexes showed yearly increases in SLJ in all ages. In boys, the 50th percentile SLJ score ranged from 109 to 165 cm. In girls, the 50th percentile jump ranged from 96 to 120 cm. For girls, jump scores increased yearly from age 9 to 12.9 years before reaching a plateau at an age between 13 and 15.9. Our results provide, for the first time, sex- and age-specific SLJ reference values for Colombian schoolchildren aged 9-17.9 years. The normative values presented in this study provide the basis for the determination of the proposed age- and sex-specific standards for the FUPRECOL (Association for Muscular Strength with Early Manifestation of Cardiovascular Disease Risk Factors Among Colombian Children and Adolescents) Study-Physical fitness battery for children and adolescents.

Report to the Legislature on Scoliosis Screening Cost/Benefit Analysis.

ERIC Educational Resources Information Center

Washington Office of the State Superintendent of Public Instruction, Olympia.

A report is given of an analysis of costs and benefits of scoliosis screening tests given to children in the 9th and 10th grades. For comparison, an analysis is included on the effectiveness of tests in grades 5 through 8. Information was collected on the number of children in the State of Washington who underwent either brace treatment or…

The Reich Wreckers: An Analysis of the 306th Bomb Group During World War II

DTIC Science & Technology

1998-04-01

1983), 179-80. 12 Notes 4 Russell A. Strong, First Over Germany : The Story of the 306th Bombardment Group, (Winston-Salem, NC: Hunter Printing Co...306th Bombardment Group (H), GP-306-HI, in USAF Collection, AFHRA, 4. 7 Russell A. Strong, First Over Germany : The Story of the 306th Bombardment...306th Bomb Group Association, 1994), cover. 9 Russell A. Strong, First Over Germany : The Story of the 306th Bombardment Group, (Winston-Salem, NC: Hunter

A Case Study on Teaching of Energy as a Subject for 9th Graders

ERIC Educational Resources Information Center

Bezen, Sevim; Bayrak, Celal; Aykutlu, Isil

2017-01-01

This study aims to describe how energy subject is taught in 9th grades. The study is designed as a descriptive case study with the participation of 3 physics teachers and 85 students. Data were obtained through observation, interviews, and documents, and they were analyzed through descriptive analysis method. In the observations made at the…

The Demand for Water Transportation: Application of Discriminant Analysis to Commodities Shipped by Barge and Competing Modes in Ohio River and Arkansas River Areas.

DTIC Science & Technology

1980-08-01

extended to include influence of time in transit, perishability, and uncertainty in market 7Alfred Marshall, Principles of Economics , 9th Edition (McMillan...the Maritime Administration, U.S. Department of Commerce, Washington, D.C. (1974). Marshall, Alfred. Principles of Economics . 9th Edition. :.[cMillian

Improving Science Vocabulary of High School English Language Learners with Reading Disabilities

ERIC Educational Resources Information Center

Helman, Amanda L.; Calhoon, Mary Beth; Kern, Lee

2015-01-01

This study investigated the effects of a combined contextual and morphemic analysis strategy to increase prediction and analysis of science vocabulary words by three high school (9th--10th grade) English language learners with reading disabilities. A multiple baseline across participants design was used. Students analyzed science words using the…

Numerical simulation of the debris flow dynamics with an upwind scheme and specific friction treatment

NASA Astrophysics Data System (ADS)

Sánchez Burillo, Guillermo; Beguería, Santiago; Latorre, Borja; Burguete, Javier

2014-05-01

Debris flows, snow and rock avalanches, mud and earth flows are often modeled by means of a particular realization of the so called shallow water equations (SWE). Indeed, a number of simulation models have been already developed [1], [2], [3], [4], [5], [6], [7]. Debris flow equations differ from shallow water equations in two main aspects. These are (a) strong bed gradient and (b) rheology friction terms that differ from the traditional SWE. A systematic analysis of the numerical solution of the hyperbolic system of equations rising from the shallow water equations with different rheological laws has not been done. Despite great efforts have been done to deal with friction expressions common in hydraulics (such as Manning friction), landslide rheologies are characterized by more complicated expressions that may deal to unphysical solutions if not treated carefully. In this work, a software that solves the time evolution of sliding masses over complex bed configurations is presented. The set of non- linear equations is treated by means of a first order upwind explicit scheme, and the friction contribution to the dynamics is treated with a suited numerical scheme [8]. In addition, the software incorporates various rheological models to accommodate for different flow types, such as the Voellmy frictional model [9] for rock and debris avalanches, or the Herschley-Bulkley model for debris and mud flows. The aim of this contribution is to release this code as a free, open source tool for the simulation of mass movements, and to encourage the scientific community to make use of it. The code uses as input data the friction coefficients and two input files: the topography of the bed and the initial (pre-failure) position of the sliding mass. In addition, another file with the final (post-event) position of the sliding mass, if desired, can be introduced to be compared with the simulation obtained result. If the deposited mass is given, an error estimation is computed by means of the Nash-Shutcliffe statistic [10]. This error estimation can be used to calibrate the input friction coefficients, providing an efficient tool for risk analysis in many regions of the world and specially in areas with steep topographic gradients such as mountain ranges, heavily incised river networks, coastal cliffs, etc. References: [1] H. J. Koerner, "Reichweite und geschwindigkeit von bergstürzen und fleisschneelawinen". Rock Mechanics, 8, 225-256 (1976) [2] P. J. McLellan and P. K. Kaiser, "Application of a two-parameter model to rock avalanches in the mackenzine mountains". 4th International Symposium on Landslides, 135-140 (1984). [3] A. Kent and O. Hungr, "Runout characteristics of debris from dump failures in mountainous terrain: stage 2: analysis, modelling and prediction". British Columbia Mine Waste Rock Pile Research Committee and CANMET (1995). [4] O. Hungr and S. G. Evans, "Rock avalanche runout prediction using a dynamic model". 7th International Symposium on Landslides, 233-238 (1996). [5] D. Rickenmann and T. Koch, "Comparison of debris flow modelling approaches". First International Conference on Debris-Flow Hazards Mitigation: Mechanics, Prediction, and Assessment. ASCE, ed. New York. C.L. Chen (1997). [6] P. Bertolo and G. F. Wieczorek, "Calibration of numerical models for small debris flows in Yosemite Valley, California, USA". Natural Hazards in Earth System Sciences (5) 993-1001 (2005). [7] S. Beguería and Th. J. van Asch and J. P. Malet and S. Gröndahl, "A GIS-based numerical model for simulating the kinematics of mud and debris flows over complex terrain". Natural Hazards in Earth System Sciences (9) 1897-1909 (2009). [8] G. Sánchez Burillo, S. Beguería, B. Latorre and J. Burguete, "Numerical treatment of the friction term in upwind schemes in debris flow runout modelling". ASCE Journal of Hydraulic Engineering (sent for publication). [9] A. Voellmy, Über die Zerstörungskraft von Lawinen. Schweizer. Bauzeitung (1955). [10] J. E. Nash and J. V. Shutcliffe, "River flow forecasting through conceptual models part I - A discussion of principles". Journal of Hydrology, 10 (3) 282-290 (1970).

Proceedings of the Annual Conference of the International Group for the Psychology of Mathematics Education (13th, Paris, France, July 9-13, 1989), Volume 3.

ERIC Educational Resources Information Center

Vergnaud, Gerard, Ed.; Rogalski, Janine, Ed.; Artique, Michele, Ed.

This proceedings of the annual conference of the International Group for the Psychology of Mathematics Education (PME) includes the following research papers: "A Model of Understanding Two-Digit Numeration and Computation" (H. Murray & A. Olivier); "The Computer Produces a Special Graphic Situation of Learning the Change of Coordinate System" (S.…

Preoperative and postoperative serial assessments of postural balance and fall risk in patients with arthroscopic anterior cruciate ligament reconstruction.

PubMed

Gokalp, Oguzhan; Akkaya, Semih; Akkaya, Nuray; Buker, Nihal; Gungor, Harun R; Ok, Nusret; Yorukoglu, Cagdas

2016-04-27

Impaired postural balance due to somatosensory data loss with mechanical instability has been shown in patients with ACL deficiency. To assess postural balance in patients with ACL insufficiency prior to surgery and following reconstruction with serial evaluations. Thirty patients (mean age of 27.7 ± 6.7 years) who underwent arthroscopic reconstruction of ACL with bone-patellar tendon-bone autograft were examined for clinical and functional variables at preoperative day and postoperative 12th week. Posturographic analysis were performed by using Tetrax Interactive Balance System (Sunlight Medical Ltd, Israel) at preoperative day, at 4th, 8th, and 12th weeks following reconstruction. Data computed by posturographic software by the considerations of the oscillation velocities of body sways is fall risk as a numeric value (0-100, lower values indicate better condition). All of the patients (mean age of 27.7 ± 6.7 years) had significant improvements for clinical, functional evaluations and fall risk (p< 0.05). Mean fall risk was within high-risk category (59.9 ± 22.8) preoperatively. The highest fall risk was detected at postoperative 4th week. Patients had high fall risk at 8th week similar to preoperative value. Mean fall risk decreased to low level risk at 12th week. Preoperative symptom duration had relationships with preoperative fall risk and postoperative improvement of fall risk (p= 0.001, r= -0.632, p= 0.001, r= -0.870, respectively). The improvement of fall risk was higher in patients with symptoms shorter than 6 months (p= 0.001). According to these results, mean fall risk of patients with ACL insufficiency was within high risk category preoperatively, and fall risk improves after surgical reconstruction, but as the duration of complaints lengthens especially longer than 6 months, the improvement of fall risk decreases following reconstruction.

Fortified Settlements of the 9th and 10th Centuries ad in Central Europe: Structure, Function and Symbolism

PubMed Central

Herold, Hajnalka

2012-01-01

THE STRUCTURE, FUNCTION(S) and symbolism of early medieval (9th–10th centuries ad) fortified settlements from central Europe, in particular today’s Austria, Hungary, Czech Republic and Slovakia, are examined in this paper. It offers an overview of the current state of research together with new insights based on analysis of the site of Gars-Thunau in Lower Austria. Special emphasis is given to the position of the fortified sites in the landscape, to the elements of the built environment and their spatial organisation, as well as to graves within the fortified area. The region under study was situated on the SE border of the Carolingian (and later the Ottonian) Empire, with some of the discussed sites lying in the territory of the ‘Great Moravian Empire’ in the 9th and 10th centuries. These sites can therefore provide important comparative data for researchers working in other parts of the Carolingian Empire and neighbouring regions. PMID:23564981

The Analysis of High School Students' Tendencies about Lifelong Learning

ERIC Educational Resources Information Center

Pesen, Ata; Epçaçan, Cevdet

2017-01-01

This study was conducted to analyze whether there was a significant difference among secondary school students' tendencies about lifelong learning in terms of gender and grade variables. The participants were 466 students studying at different high schools in the central province of Siirt at 9th, 10th and 11th grades, who were chosen randomly.…

Comparison of fMRI analysis methods for heterogeneous BOLD responses in block design studies

PubMed Central

Bernal-Casas, David; Fang, Zhongnan; Lee, Jin Hyung

2017-01-01

A large number of fMRI studies have shown that the temporal dynamics of evoked BOLD responses can be highly heterogeneous. Failing to model heterogeneous responses in statistical analysis can lead to significant errors in signal detection and characterization and alter the neurobiological interpretation. However, to date it is not clear that, out of a large number of options, which methods are robust against variability in the temporal dynamics of BOLD responses in block-design studies. Here, we used rodent optogenetic fMRI data with heterogeneous BOLD responses and simulations guided by experimental data as a means to investigate different analysis methods’ performance against heterogeneous BOLD responses. Evaluations are carried out within the general linear model (GLM) framework and consist of standard basis sets as well as independent component analysis (ICA). Analyses show that, in the presence of heterogeneous BOLD responses, conventionally used GLM with a canonical basis set leads to considerable errors in the detection and characterization of BOLD responses. Our results suggest that the 3rd and 4th order gamma basis sets, the 7th to 9th order finite impulse response (FIR) basis sets, the 5th to 9th order B-spline basis sets, and the 2nd to 5th order Fourier basis sets are optimal for good balance between detection and characterization, while the 1st order Fourier basis set (coherence analysis) used in our earlier studies show good detection capability. ICA has mostly good detection and characterization capabilities, but detects a large volume of spurious activation with the control fMRI data. PMID:27993672

Using Static Percentiles of AE9/AP9 to Approximate Dynamic Monte Carlo Runs for Radiation Analysis of Spiral Transfer Orbits

NASA Astrophysics Data System (ADS)

Kwan, Betty P.; O'Brien, T. Paul

2015-06-01

The Aerospace Corporation performed a study to determine whether static percentiles of AE9/AP9 can be used to approximate dynamic Monte Carlo runs for radiation analysis of spiral transfer orbits. Solar panel degradation is a major concern for solar-electric propulsion because solar-electric propulsion depends on the power output of the solar panel. Different spiral trajectories have different radiation environments that could lead to solar panel degradation. Because the spiral transfer orbits only last weeks to months, an average environment does not adequately address the possible transient enhancements of the radiation environment that must be accounted for in optimizing the transfer orbit trajectory. Therefore, to optimize the trajectory, an ensemble of Monte Carlo simulations of AE9/AP9 would normally be run for every spiral trajectory to determine the 95th percentile radiation environment. To avoid performing lengthy Monte Carlo dynamic simulations for every candidate spiral trajectory in the optimization, we found a static percentile that would be an accurate representation of the full Monte Carlo simulation for a representative set of spiral trajectories. For 3 LEO to GEO and 1 LEO to MEO trajectories, a static 90th percentile AP9 is a good approximation of the 95th percentile fluence with dynamics for 4-10 MeV protons, and a static 80th percentile AE9 is a good approximation of the 95th percentile fluence with dynamics for 0.5-2 MeV electrons. While the specific percentiles chosen cannot necessarily be used in general for other orbit trade studies, the concept of determining a static percentile as a quick approximation to a full Monte Carlo ensemble of simulations can likely be applied to other orbit trade studies. We expect the static percentile to depend on the region of space traversed, the mission duration, and the radiation effect considered.

Electron-cyclotron absorption in high-temperature plasmas: quasi-exact analytical evaluation and comparative numerical analysis

NASA Astrophysics Data System (ADS)

Albajar, F.; Bertelli, N.; Bornatici, M.; Engelmann, F.

2007-01-01

On the basis of the electromagnetic energy balance equation, a quasi-exact analytical evaluation of the electron-cyclotron (EC) absorption coefficient is performed for arbitrary propagation (with respect to the magnetic field) in a (Maxwellian) magneto-plasma for the temperature range of interest for fusion reactors (in which EC radiation losses tend to be important in the plasma power balance). The calculation makes use of Bateman's expansion for the product of two Bessel functions, retaining the lowest-order contribution. The integration over electron momentum can then be carried out analytically, fully accounting for finite Larmor radius effects in this approximation. On the basis of the analytical expressions for the EC absorption coefficients of both the extraordinary and ordinary modes thus obtained, (i) for the case of perpendicular propagation simple formulae are derived for both modes and (ii) a numerical analysis of the angular distribution of EC absorption is carried out. An assessment of the accuracy of asymptotic expressions that have been given earlier is also performed, showing that these approximations can be usefully applied for calculating EC power losses from reactor-grade plasmas. Presented in part at the 14th Joint Workshop on Electron Cyclotron Emission and Electron Cyclotron Resonance Heating, Santorini, Greece, 9-12 May 2006.

Pulmonary tuberculosis in Asian elephants (Elephas maximus): histologic lesions with correlation to local immune responses.

PubMed

Landolfi, J A; Terio, K A; Miller, M; Junecko, B F; Reinhart, T

2015-05-01

Although Mycobacterium tuberculosis infection is an important health concern for Asian elephants (Elephas maximus), no studies have evaluated the associated local immune responses or histologic lesions. In primates including humans, latent tuberculosis is distinguished by well-organized granulomas with TH1 cytokine expression, whereas active disease is characterized by poorly organized inflammation and local imbalance in TH1/TH2 cytokines. This study examined archival, formalin-fixed, paraffin-embedded lung samples from 5 tuberculosis-negative and 9 tuberculosis-positive Asian elephants. Lesions were assessed by light microscopy, and lymphoid infiltrates were characterized by CD3 and CD20 immunolabeling. Expression of TH1 (interferon [IFN]-γ, tumor necrosis factor [TNF]-α) and TH2 (interleukin [IL]-4, IL-10, transforming growth factor [TGF]-β) cytokines was determined using in situ hybridization. In 6 of 9 samples, inflammation was similar to the pattern of primate active disease with low to moderate numbers of lymphocytes, most of which were CD20 positive. In 1 sample, inflammation was most similar to latent tuberculosis in primates with numerous CD3-positive lymphocytes. Expression of IFN-γ was detected in 3 of 8 tuberculosis-positive samples. Expression of TNF-α was detected in 3 of 8 positive samples, including the one with latent morphology. Low-level expression of IL-4 was present in 4 of 8 positive samples. Only single positive samples displayed expression of IL-10 and TGF-β. Tuberculosis-negative samples generally lacked cytokine expression. Results showed heterogeneity in lesions of elephant tuberculosis similar to those of latent and active disease in primates, with variable expression of both TH1 and TH2 cytokines. © The Author(s) 2014.

Inbreeding trends and pedigree analysis of Bavarian mountain hounds, Hanoverian hounds and Tyrolean hounds.

PubMed

Voges, S; Distl, O

2009-10-01

The objective of this study was to analyse genetic diversity for the three scent-hound breeds Bavarian mountain hound (BMH), Hanoverian hound (HH) and Tyrolean hound (TH) using all available pedigree information from scent-hound kennel clubs for these three breeds throughout Europe. The pedigree data of the BMH and the HH date back to 1912 and 1894, respectively. Pedigree data of the TH were available from the 1960s onwards. The reference populations included all BMH (n = 3231), HH (n = 1371) and TH (n = 1167) dogs registered between 1992 and 2004. Average generation intervals were 5.3 years for the BMH and 5.0 years for the HH and TH. Average inbreeding coefficients for the reference populations were 4.5%, 6.8% and 9.5% for the BMH, HH and TH. The effective numbers of founders, ancestors and founder genomes were lowest for the TH and highest for the BMH. The effective numbers of founder genomes were 10.9, 5.6 and 4.3 for the BMH, HH and TH. Effective population size was largest for the BMH with 72.7 effective breeding animals, followed by the HH with 50.9 and TH with 26.5. The most important ten ancestors had genetic contributions to the reference populations of 54.4%, 65.2% and 77.9% in the BMH, HH and TH. The results of our study indicate the need for careful breed management in these highly specialized hound breeds to maintain genetic diversity. European stud books should be established for these dog breeds in order to avoid inbreeding due to missing pedigree records.

Gestational dietary patterns are not associated with blood pressure changes during pregnancy and early postpartum in a Brazilian prospective cohort.

PubMed

Eshriqui, Ilana; Vilela, Ana Amélia Freitas; Rebelo, Fernanda; Farias, Dayana Rodrigues; Castro, Maria Beatriz Trindade; Kac, Gilberto

2016-02-01

To identify gestational dietary patterns and evaluate the association between these patterns and the blood pressure (BP) rate of change during pregnancy and the postpartum. Prospective cohort study composed of 191 healthy pregnant women. Systolic BP (SBP) and diastolic BP (DBP) were obtained at the 5th-13th, 20th-26th, 30th-36th gestational weeks, and with 30-45 days postpartum. A food frequency questionnaire administered at the 30th-36th gestational week was used to measure dietary intake during pregnancy. Principal component analysis was performed to identify the dietary patterns. A longitudinal linear mixed-effects regression model was used to evaluate the association between the dietary patterns and BP (adjusted for time elapsed after conception and the women's age, education, parity, body mass index and total energy intake). Three gestational dietary patterns were identified: healthy, common-Brazilian and processed. SBP/DBP mean values (SD) were 110.1 (9.0)/66.9 (7.5), 108.7 (9.0)/64.9 (6.7), 111.3 (9.2)/67.0 (6.9) and 115.0 (10.7)/73.7 (8.6) mmHg at the first, second and third gestational trimesters and postpartum, respectively. Women with higher/lower adherence to the processed pattern presented SBP of 117.9 and 113.0 mmHg (P = 0.037), respectively, during postpartum. No association was found between any of the three dietary patterns and SBP in the multiple longitudinal linear regression models, whereas 1 SD increase in the common-Brazilian pattern was associated with a small change of DBP (β = 0.0006; 95% CI 4.66e-06, 0.001; P = 0.048). The three dietary patterns identified revealed no association with changes of SBP and DBP levels during pregnancy and at early postpartum in this sample of healthy Brazilian women.

Social Capital and Adolescents Mathematics Achievement: A Comparative Analysis of Eight European Cities

ERIC Educational Resources Information Center

Gisladottir, Berglind

2013-01-01

This study examines the impact of social capital on mathematics achievement in eight European cities. The study draws on data from the 2008 Youth in Europe survey, carried out by the Icelandic Center for Social Research and Analysis. The sample contains responses from 17,312 students in 9th and 10th grade of local secondary schools in the…

Endocrinology Telehealth Consultation Improved Glycemic Control Similar to Face-to-Face Visits in Veterans

PubMed Central

Liu, Winnie; Saxon, David R.; McNair, Bryan; Sanagorski, Rebecca; Rasouli, Neda

2016-01-01

Background: Rates of diabetes for veterans who receive health care through the Veterans Health Administration are higher than rates in the general population. Furthermore, many veterans live in rural locations, far from Veterans Affairs (VA) hospitals, thus limiting their ability to readily seek face-to-face endocrinology care for diabetes. Telehealth (TH) technologies present an opportunity to improve access to specialty diabetes care for such patients; however, there is a lack of evidence regarding the ability of TH to improve glycemic control in comparison to traditional face-to-face consultations. Methods: This was a retrospective cohort study of all new endocrinology diabetes consultations at the Denver VA Medical Center over a 1-year period. Results: A total of 189 patients were included in the analysis. In all, 85 patients had received face-to-face (FTF) endocrinology consultation for diabetes and 104 patients had received TH consultation. Subjects were mostly males (94.7%) and the mean age was 62.8 ± 10.1 years old. HbA1c improved from 9.76% (9.40% to 10.11%) to 8.55% (8.20% to 8.91%) (P < .0001) for the TH group and from 9.56% (9.16% to 9.95%) to 8.62% (8.22% to 9.01%) (P < .0001) for the FTF group after 1 visit. This change in HbA1c was not significantly different in the TH and FTF groups (P = .24). TH visits were associated with a hypothetical savings in median distance traveled of 231.2 miles per trip (which equates to $94.79 saved per trip). Conclusions: Endocrinology TH consultations improved short-term glycemic control as effectively as traditional FTF visits in a veteran population with diabetes. PMID:27170633

Endocrinology Telehealth Consultation Improved Glycemic Control Similar to Face-to-Face Visits in Veterans.

PubMed

Liu, Winnie; Saxon, David R; McNair, Bryan; Sanagorski, Rebecca; Rasouli, Neda

2016-09-01

Rates of diabetes for veterans who receive health care through the Veterans Health Administration are higher than rates in the general population. Furthermore, many veterans live in rural locations, far from Veterans Affairs (VA) hospitals, thus limiting their ability to readily seek face-to-face endocrinology care for diabetes. Telehealth (TH) technologies present an opportunity to improve access to specialty diabetes care for such patients; however, there is a lack of evidence regarding the ability of TH to improve glycemic control in comparison to traditional face-to-face consultations. This was a retrospective cohort study of all new endocrinology diabetes consultations at the Denver VA Medical Center over a 1-year period. A total of 189 patients were included in the analysis. In all, 85 patients had received face-to-face (FTF) endocrinology consultation for diabetes and 104 patients had received TH consultation. Subjects were mostly males (94.7%) and the mean age was 62.8 ± 10.1 years old. HbA1c improved from 9.76% (9.40% to 10.11%) to 8.55% (8.20% to 8.91%) (P < .0001) for the TH group and from 9.56% (9.16% to 9.95%) to 8.62% (8.22% to 9.01%) (P < .0001) for the FTF group after 1 visit. This change in HbA1c was not significantly different in the TH and FTF groups (P = .24). TH visits were associated with a hypothetical savings in median distance traveled of 231.2 miles per trip (which equates to $94.79 saved per trip). Endocrinology TH consultations improved short-term glycemic control as effectively as traditional FTF visits in a veteran population with diabetes. © 2016 Diabetes Technology Society.

Development of fraction comparison strategies: A latent transition analysis.

PubMed

Rinne, Luke F; Ye, Ai; Jordan, Nancy C

2017-04-01

The present study investigated the development of fraction comparison strategies through a longitudinal analysis of children's responses to a fraction comparison task in 4th through 6th grades (N = 394). Participants were asked to choose the larger value for 24 fraction pairs blocked by fraction type. Latent class analysis of performance over item blocks showed that most children initially exhibited a "whole number bias," indicating that larger numbers in numerators and denominators produce larger fraction values. However, some children instead chose fractions with smaller numerators and denominators, demonstrating a partial understanding that smaller numbers can yield larger fractions. Latent transition analysis showed that most children eventually adopted normative comparison strategies. Children who exhibited a partial understanding by choosing fractions with smaller numbers were more likely to adopt normative comparison strategies earlier than those with larger number biases. Controlling for general math achievement and other cognitive abilities, whole number line estimation accuracy predicted the probability of transitioning to normative comparison strategies. Exploratory factor analyses showed that over time, children appeared to increasingly represent fractions as discrete magnitudes when simpler strategies were unavailable. These results support the integrated theory of numerical development, which posits that an understanding of numbers as magnitudes unifies the process of learning whole numbers and fractions. The findings contrast with conceptual change theories, which propose that children must move from a view of numbers as counting units to a new view that accommodates fractions to overcome whole number bias. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Device Longevity in a Contemporary Cohort of ICD/CRT-D Patients Undergoing Device Replacement.

PubMed

Zanon, Francesco; Martignani, Cristian; Ammendola, Ernesto; Menardi, Endrj; Narducci, Maria Lucia; DE Filippo, Paolo; Santamaria, Matteo; Campana, Andrea; Stabile, Giuseppe; Potenza, Domenico Rosario; Pastore, Gianni; Iori, Matteo; LA Rosa, Concetto; Biffi, Mauro

2016-07-01

The longevity of defibrillators (ICD) is extremely important from both a clinical and economic perspective. We studied the reasons for device replacement, the longevity of removed ICD, and the existence of possible factors associated with shorter service life. Consecutive patients who underwent ICD replacement from March 2013 to May 2015 in 36 Italian centers were included in this analysis. Data on replaced devices were collected. A total of 953 patients were included in this analysis. In 813 (85%) patients the reason for replacement was battery depletion, while 88 (9%) devices were removed for clinical reasons and the remaining 52 because of system failure (i.e., lead or ICD generator failure or a safety advisory indication). The median service life was 5.9 years (25th-75th percentile, 4.9-6.9) for single- and dual-chamber ICD and 4.9 years (25th-75th percentile, 4.0-5.7) for CRT-D. On multivariate analysis, the factors CRT-D device, SC/DC ICD generator from Biotronik, percentage of ventricular pacing, and the occurrence of a system failure were positively associated with a replacement procedure. By contrast, the device from Boston Scientific was an independent protective factor against replacement. Considerable differences were seen in battery duration in both ICD and CRT-D. Specifically, Biotronik devices showed the shortest longevity among ICD and Boston Scientific showed the longest longevity among CRT-D (log-rank test, P < 0.001 for pairwise comparisons). Several factors were associated with shorter service life of ICD devices: CRT-D, occurrence of system failure and percentage of ventricular pacing. Our results confirmed significant differences among manufacturers. © The Authors. Journal of Cardiovascular Electrophysiology published by Wiley Periodicals, Inc.

[A Comparative Study of Acute and Chronic Pain between Single Port and Triple Port Video-assisted Thoracic Surgery for Lung Cancer].

PubMed

Li, Caiwei; Xu, Meiqing; Xu, Guangwen; Xiong, Ran; Wu, Hanran; Xie, Mingran

2018-04-20

Through the comparative analysis of the acute and chronic pain postoperative between the single port and triple port video-assisted thoracic surgery to seek the better method which can reduce the incidence of acute and chronic pain in patients with lung cancer. Data of 232 patients who underwent single port -VATS (n=131) or triple port VATS (n=101) for non-small cell lung cancer (NSCLC) on January 1, 2016 to June 30, 2017 in our hospital were analyzed. The clinical and operative data were assessed, numeric rating scale (NRS) was used to evaluate the mean pain score on the 1th, 2th, 3th, 7th, 14th days, 3th months and 6th months postoperative. Both groups were similar in clinical characteristics, there were no perioperative death in two groups. In the 1th, 2th, 7th, 14th days and 3th, 6th months postoperative, the NRS score of the single port group was superior, and the difference was significant compared with the triple port (P<0.05). There was no statistically significant difference between the two groups in operative time, blood loss, postoperative hospitalization time, duration of chest tube, the NRS scores in the 3 d (P>0.05). Univariate and multivariate analysis of the occurrence on the chronic pain showed that the operation time, surgical procedure and the 14th NRS score were risk factors for chronic pain (P<0.05). The single port thoracoscopic surgery has an advantage in the incidence of acute and chronic pain in patients with non-small cell lung cancer. Shorter operative time can reduce the occurrence of chronic pain. The 14th day NRS score is a risk factor for chronic pain postoperative.

Alkaline Cytosolic pH and High Sodium Hydrogen Exchanger 1 (NHE1) Activity in Th9 Cells.

PubMed

Singh, Yogesh; Zhou, Yuetao; Shi, Xiaolong; Zhang, Shaqiu; Umbach, Anja T; Salker, Madhuri S; Lang, Karl S; Lang, Florian

2016-11-04

CD4 + T helper 9 (Th9) cells are a newly discovered Th cell subset that produce the pleiotropic cytokine IL-9. Th9 cells can protect against tumors and provide resistance against helminth infections. Given their pivotal role in the adaptive immune system, understanding Th9 cell development and the regulation of IL-9 production could open novel immunotherapeutic opportunities. The Na + /H + exchanger 1 (NHE1; gene name Slc9α1)) is critically important for regulating intracellular pH (pH i ), cell volume, migration, and cell survival. The pH i influences cytokine secretion, activities of membrane-associated enzymes, ion transport, and other effector signaling molecules such as ATP and Ca 2+ levels. However, whether NHE1 regulates Th9 cell development or IL-9 secretion has not yet been defined. The present study explored the role of NHE1 in Th9 cell development and function. Th cell subsets were characterized by flow cytometry and pH i was measured using 2',7'-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein-acetoxymethyl ester (BCECF-AM) dye. NHE1 functional activity was estimated from the rate of realkalinization following an ammonium pulse. Surprisingly, in Th9 cells pH i and NHE1 activity were significantly higher than in all other Th cell subsets (Th1/Th2/Th17 and induced regulatory T cells (iTregs)). NHE1 transcript levels and protein abundance were significantly higher in Th9 cells than in other Th cell subsets. Inhibition of NHE1 by siRNA-NHE1 or with cariporide in Th9 cells down-regulated IL-9 and ATP production. NHE1 activity, Th9 cell development, and IL-9 production were further blunted by pharmacological inhibition of protein kinase Akt1/Akt2. Our findings reveal that Akt1/Akt2 control of NHE1 could be an important physiological regulator of Th9 cell differentiation, IL-9 secretion, and ATP production. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Increasing seismic activity at 9deg50'N on the East Pacific Rise RIDGE 2000 Integrated Studies Site from October 2003 through April 2004

NASA Astrophysics Data System (ADS)

Weekly, R. T.; Tolstoy, M.; Waldhauser, F.; Bohnenstiehl, D. R.; Kim, W.

2005-12-01

Monitoring of micro-seismicity within the bull's-eye region of the R2K ISS at 9deg49'N - 9deg51'N on the East Pacific Rise has been ongoing since October 2003. Results from the first deployment (October 2003 - April 2004) will be presented with hypocenters determined using relative-relocation techniques. Analysis shows that there is a gradual and ongoing increase in the rate of activity over the 7 months of the deployment. Mean event rates increase from 31 events/day for the first quarter of the deployment period, to 55, 105, and 131 events per day for the 2nd, 3rd and 4th quarters, respectively. This gradual increase in activity suggests long-term changes in the magma body or changes in the hydrothermal cracking front. Preliminary analysis and event counts for the 2004-2005 deployment will be presented to assess whether or not the build up in activity seen in 2003-2004 continued. Numerous brief swarms are observed throughout the deployment and their locations will be studied relative to temporal changes in the vent temperature monitoring as well as variations in the fluid chemistry (see Von Damm et al., same session). Early analysis suggests two dominant areas of recurrent activity, between M-vent and Bio-9 and between Bio-9 and Tube-worm pillar. The exceptionally well-characterized and monitored seafloor at this site allows for unprecedented correlation of observed seismic activity with local biology, geology, geochemical and hydrothermal monitoring. As results from different monitoring activities continue to come in, a detailed understanding of the linkages should emerge.

Rapamycin resistant murine th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity.

PubMed

Mangus, Courtney W; Massey, Paul R; Fowler, Daniel H; Amarnath, Shoba

2013-01-01

The cytokine micro-environment can direct murine CD4(+) T cells towards various differentiation lineages such as Th1, Th2 and Tregs even in the presence of rapamycin, which results in T cells that mediate increased in vivo effects. Recently, a new lineage of T cells known as Th9 cells that secrete increased IL-9 have been described. However, it is not known whether Th9 differentiation occurs in the presence of rapamycin or whether adoptively transferred donor Th9 cells would augment or restrict alloreactivity after experimental bone marrow transplantation. We found that CD4(+) T cells that were co-stimulated and polarized with TGF-β and IL-4 in the presence or absence of rapamycin each yielded effector cells of Th9 phenotype that secreted increased IL-9 and expressed a transcription factor profile characteristic of both Th9 and Th2 cells (high GATA-3/low T-bet). Augmentation of T cell replete allografts with manufactured rapamycin resistant Th9 cells markedly reduced both CD4(+) and CD8(+) T cell engraftment and strongly inhibited allo-specific T cell secretion of IFN-γ. The potency of Th9 cell inhibition of alloreactivity was similar to that of rapamycin resistant Th2 cells. Importantly, rapamycin resistant Th9 cells persisted and maintained their cytokine phenotype, thereby indicating limited differentiation plasticity of the Th9 subset. As such, Th9 differentiation proceeds in the presence of rapamycin to generate a cell therapy product that maintains high IL-9 expression in vivo while inhibiting IFN-γ driven alloreactivity.

DNS of Flows over Periodic Hills using a Discontinuous-Galerkin Spectral-Element Method

NASA Technical Reports Server (NTRS)

Diosady, Laslo T.; Murman, Scott M.

2014-01-01

Direct numerical simulation (DNS) of turbulent compressible flows is performed using a higher-order space-time discontinuous-Galerkin finite-element method. The numerical scheme is validated by performing DNS of the evolution of the Taylor-Green vortex and turbulent flow in a channel. The higher-order method is shown to provide increased accuracy relative to low-order methods at a given number of degrees of freedom. The turbulent flow over a periodic array of hills in a channel is simulated at Reynolds number 10,595 using an 8th-order scheme in space and a 4th-order scheme in time. These results are validated against previous large eddy simulation (LES) results. A preliminary analysis provides insight into how these detailed simulations can be used to improve Reynoldsaveraged Navier-Stokes (RANS) modeling

Comparison of fMRI analysis methods for heterogeneous BOLD responses in block design studies.

PubMed

Liu, Jia; Duffy, Ben A; Bernal-Casas, David; Fang, Zhongnan; Lee, Jin Hyung

2017-02-15

A large number of fMRI studies have shown that the temporal dynamics of evoked BOLD responses can be highly heterogeneous. Failing to model heterogeneous responses in statistical analysis can lead to significant errors in signal detection and characterization and alter the neurobiological interpretation. However, to date it is not clear that, out of a large number of options, which methods are robust against variability in the temporal dynamics of BOLD responses in block-design studies. Here, we used rodent optogenetic fMRI data with heterogeneous BOLD responses and simulations guided by experimental data as a means to investigate different analysis methods' performance against heterogeneous BOLD responses. Evaluations are carried out within the general linear model (GLM) framework and consist of standard basis sets as well as independent component analysis (ICA). Analyses show that, in the presence of heterogeneous BOLD responses, conventionally used GLM with a canonical basis set leads to considerable errors in the detection and characterization of BOLD responses. Our results suggest that the 3rd and 4th order gamma basis sets, the 7th to 9th order finite impulse response (FIR) basis sets, the 5th to 9th order B-spline basis sets, and the 2nd to 5th order Fourier basis sets are optimal for good balance between detection and characterization, while the 1st order Fourier basis set (coherence analysis) used in our earlier studies show good detection capability. ICA has mostly good detection and characterization capabilities, but detects a large volume of spurious activation with the control fMRI data. Copyright © 2016 Elsevier Inc. All rights reserved.

Former 9th and possible future 9th planet in the Solar system

NASA Astrophysics Data System (ADS)

Vidmachenko, A. P.

2016-12-01

4 terrestrial planets and 4 giant planets were formed in the Solar system. The Main asteroid belt is located between them, and the Kuiper belt and Oort cloud are located beyond the giant planets. Therefore, the planetary system is surrounded by a swarm of rocky-icy bodies up to a distance of 105 AU. The former 9th planet in the Solar system, Pluto, is the first known object of the Kuiper Belt. Due to data from the spacecraft "New Horizons" we made significant progress in the study of the physical characteristics of the object and its surface. Numerous observations have shown that the Kuiper belt itself is dynamically stable. And the source of cometary nuclei is a disk scattered by the gravitational perturbation of the giant planets more than 4 billion years ago. Recently, it was reported on indirect evidence of the existence of a new 9th planet in the Solar system with a mass 10 times greater than the mass of the Earth, a distance from the Sun ∼200 AU at perihelion, 600-1200 AU at aphelion, and an orbital period of ∼15000 years. These conclusions are based on the calculation of the orbits of 6 presently known objects of the scattered disc. We pay attention that, in moments close to their discovery, they were located near the perihelion, had a maximum brightness and a maximum orbital velocity. On the basis of probabilistic assumptions, we estimated that the probable number of the same bodies with eccentric orbits should be estimated at many thousands rather than at a few. For the initial evaluation, we used observational data from the Infrared Space Telescope "WISE". They showed that any Saturn's analog has not been registered at distances up to 30 000 AU. Therefore, a super-Earth with a radius of <11000 km (with a mass of ∼10 Earth masses) would have been seen at a distance up to 1000 AU. Thus, either unknown 9th planet is now at a greater distance, or these results cannot be directly scaled to the super-Earth with a disproporti! onately lower internal heat reserves.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yuan, Aping; Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University, Henan; Yang, Hang

Diverse T help (Th) cells play a crucial role in the processing and maintaining of chronic inflammation as seen in ulcerative colitis (UC). Th9, a novel subset of Th cells that primarily produces interleukin (IL)-9, has recently been associated with the development of inflammatory diseases. In this study, we evaluated the presentation of Th9 cells in inflamed tissues of human and experimental mouse UC, and examined the therapeutic efficiency of anti Th9 cytokine IL-9 in the experimental mouse UC. Using immunohistochemistry (IHC), we evaluated the presentation of Th9 cells labelled by transcriptional factor PU.1 in both human and dextran sulfatemore » sodium (DSS) induced mouse colitis biopsies. The results showed that increased PU.1 positive Th9 cells were mainly located in the lamina propria in relative with the controls, intraepithelial Th9 cells can also be observed but at low density. Double IHCs revealed that most of PU.1 positive cells were CD3 positive lymphocytes in human UC specimens. Anti-IL-9 antibody injection for 2 weeks reduced the severity of inflammation in DSS induced colitis mice. Our results suggest that The Th9/IL-9 is involved in the pathogenesis of UC. - Highlights: • The density of novel PU.1 positive Th9 cells is significantly increased in both human and mouse colitis tissues. • PU.1 positive Th9 cells are predominately located in the inflamed lamina propria in both human and mouse colitis tissues. • Blocking of Th9 cytokine IL-9 by antibody injection suppresses the severity of inflammation in the bowel in colitis mice. • Novel Th9 cells contribute to the pathogenesis of UC.« less

Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.

PubMed

Zhang, Qian; Luan, Hong; Wang, Le; He, Fan; Zhou, Huan; Xu, Xiaoli; Li, Xingai; Xu, Qing; Niki, Toshiro; Hirashima, Mitsuomi; Xu, Gang; Lv, Yongman; Yuan, Jin

2014-04-15

Antiglomerular basement membrane glomerulonephritis (anti-GBM GN) is a Th1- and Th17-predominant autoimmune disease. Galectin-9 (Gal-9), identified as the ligand of Tim-3, functions in diverse biological processes and leads to the apoptosis of CD4(+)Tim-3(+) T cells. It is still unclear how Gal-9 regulates the functions of Th1 and Th17 cells and prevents renal injury in anti-GBM GN. In this study, Gal-9 was administered to anti-GBM GN mice for 7 days. We found that Gal-9 retarded the increase of Scr, ameliorated renal tubular injury, and reduced the formation of crescents. The infiltration of Th1 and Th17 cells into the spleen and kidneys significantly decreased in Gal-9-treated nephritic mice. The reduced infiltration of Th1 and Th17 cells might be associated with the downregulation of CCL-20, CXCL-9, and CXCL-10 mRNAs in the kidney. In parallel, the blood levels of IFN-γ and IL-17A declined in Gal-9-treated nephritic mice at days 21 and 28. In addition, an enhanced Th2 cell-mediated immune response was observed in the kidneys of nephritic mice after a 7-day injection of Gal-9. In conclusion, the protective role of Gal-9 in anti-GBM GN is associated with the inhibition of Th1 and Th17 cell-mediated immune responses and enhanced Th2 immunity in the kidney.

Nitric oxide enhances Th9 cell differentiation and airway inflammation.

PubMed

Niedbala, Wanda; Besnard, Anne-Gaelle; Nascimento, Daniele Carvalho; Donate, Paula Barbim; Sonego, Fabiane; Yip, Edwin; Guabiraba, Rodrigo; Chang, Hyun-Dong; Fukada, Sandra Y; Salmond, Robert J; Schmitt, Edgar; Bopp, Tobias; Ryffel, Bernhard; Liew, Foo Y

2014-08-07

Th9 cells protect hosts against helminthic infection but also mediate allergic disease. Here we show that nitric oxide (NO) promotes Th9 cell polarization of murine and human CD4(+) T cells. NO de-represses the tumour suppressor gene p53 via nitrosylation of Mdm2. NO also increases p53-mediated IL-2 production, STAT5 phosphorylation and IRF4 expression, all essential for Th9 polarization. NO also increases the expression of TGFβR and IL-4R, pivotal to Th9 polarization. OVA-sensitized mice treated with an NO donor developed more severe airway inflammation. Transferred Th9 cells induced airway inflammation, which was exacerbated by NO and blocked by anti-IL-9 antibody. Nos2(-/-) mice had less Th9 cells and developed attenuated eosinophilia during OVA-induced airway inflammation compared with wild-type mice. Our data demonstrate that NO is an important endogenous inducer of Th9 cells and provide a hitherto unrecognized mechanism for NO-mediated airway inflammation via the expansion of Th9 cells.

Higher-order triangular spectral element method with optimized cubature points for seismic wavefield modeling

NASA Astrophysics Data System (ADS)

Liu, Youshan; Teng, Jiwen; Xu, Tao; Badal, José

2017-05-01

The mass-lumped method avoids the cost of inverting the mass matrix and simultaneously maintains spatial accuracy by adopting additional interior integration points, known as cubature points. To date, such points are only known analytically in tensor domains, such as quadrilateral or hexahedral elements. Thus, the diagonal-mass-matrix spectral element method (SEM) in non-tensor domains always relies on numerically computed interpolation points or quadrature points. However, only the cubature points for degrees 1 to 6 are known, which is the reason that we have developed a p-norm-based optimization algorithm to obtain higher-order cubature points. In this way, we obtain and tabulate new cubature points with all positive integration weights for degrees 7 to 9. The dispersion analysis illustrates that the dispersion relation determined from the new optimized cubature points is comparable to that of the mass and stiffness matrices obtained by exact integration. Simultaneously, the Lebesgue constant for the new optimized cubature points indicates its surprisingly good interpolation properties. As a result, such points provide both good interpolation properties and integration accuracy. The Courant-Friedrichs-Lewy (CFL) numbers are tabulated for the conventional Fekete-based triangular spectral element (TSEM), the TSEM with exact integration, and the optimized cubature-based TSEM (OTSEM). A complementary study demonstrates the spectral convergence of the OTSEM. A numerical example conducted on a half-space model demonstrates that the OTSEM improves the accuracy by approximately one order of magnitude compared to the conventional Fekete-based TSEM. In particular, the accuracy of the 7th-order OTSEM is even higher than that of the 14th-order Fekete-based TSEM. Furthermore, the OTSEM produces a result that can compete in accuracy with the quadrilateral SEM (QSEM). The high accuracy of the OTSEM is also tested with a non-flat topography model. In terms of computational efficiency, the OTSEM is more efficient than the Fekete-based TSEM, although it is slightly costlier than the QSEM when a comparable numerical accuracy is required.

PREFACE: 9th International Symposium on Cavitation (CAV2015)

NASA Astrophysics Data System (ADS)

Farhat, M.; Müller, A.

2015-12-01

It is our pleasure and privilege to welcome all the participants of the 9th International Symposium on Cavitation (CAV2015) to Lausanne. Since its initiation in 1986 in Sendai, Japan, the CAV symposium has grown to become the world's foremost event dedicated to cavitation. Hosted by EPFL (Ecole Polytechnique Fédérale de Lausanne) and staged at the SwissTech Convention Center, CAV2015 is a unique opportunity to exchange with leading scientists and industry experts about the latest advances in theoretical modelling, numerical simulation and experimentation related to cavitation phenomena with a special emphasis on practical applications. The topics covered by CAV2015 include cavitation in ¬fluid machinery and fuel systems, bubble dynamics, cavitation erosion, advanced numerical simulation, sonochemistery, biomedicine and experimental techniques. CAV2015 will also host an exhibition of leading providers of state of the art measurement equipment, including high-speed imaging systems, non-intrusive velocimetry, pressure sensors, as well as numerical solvers. We have accepted over 190 papers, which will be presented in four parallel sessions. The proceedings will appear in the open access Journal of Physics: Conference Series (JPCS), which is part of the IOP Conference Series. All published papers are fully citable and upon publication will be free to download in perpetuity. We would like to thank all the reviewers for their great help during the selection process. We will also propose six plenary speakers to highlight cavitation issues in different fields. Finally, we would like to warmly thank our sponsors for their valuable support and the local Organizing Committee for the efforts in setting up this important event. We look forward to seeing you in Lausanne!

A comparison of three feature selection methods for object-based classification of sub-decimeter resolution UltraCam-L imagery

USDA-ARS?s Scientific Manuscript database

The availability of numerous spectral, spatial, and contextual features with object-based image analysis (OBIA) renders the selection of optimal features a time consuming and subjective process. While several feature election methods have been used in conjunction with OBIA, a robust comparison of th...

Algebraic solution for the forward displacement analysis of the general 6-6 stewart mechanism

NASA Astrophysics Data System (ADS)

Wei, Feng; Wei, Shimin; Zhang, Ying; Liao, Qizheng

2016-01-01

The solution for the forward displacement analysis(FDA) of the general 6-6 Stewart mechanism(i.e., the connection points of the moving and fixed platforms are not restricted to lying in a plane) has been extensively studied, but the efficiency of the solution remains to be effectively addressed. To this end, an algebraic elimination method is proposed for the FDA of the general 6-6 Stewart mechanism. The kinematic constraint equations are built using conformal geometric algebra(CGA). The kinematic constraint equations are transformed by a substitution of variables into seven equations with seven unknown variables. According to the characteristic of anti-symmetric matrices, the aforementioned seven equations can be further transformed into seven equations with four unknown variables by a substitution of variables using the Gröbner basis. Its elimination weight is increased through changing the degree of one variable, and sixteen equations with four unknown variables can be obtained using the Gröbner basis. A 40th-degree univariate polynomial equation is derived by constructing a relatively small-sized 9´9 Sylvester resultant matrix. Finally, two numerical examples are employed to verify the proposed method. The results indicate that the proposed method can effectively improve the efficiency of solution and reduce the computational burden because of the small-sized resultant matrix.

Nitric oxide enhances Th9 cell differentiation and airway inflammation

PubMed Central

Niedbala, Wanda; Besnard, Anne-Gaelle; Nascimento, Daniele Carvalho; Donate, Paula Barbim; Sonego, Fabiane; Yip, Edwin; Guabiraba, Rodrigo; Chang, Hyun-Dong; Fukada, Sandra Y.; Salmond, Robert J.; Schmitt, Edgar; Bopp, Tobias; Ryffel, Bernhard; Liew, Foo Y.

2014-01-01

Th9 cells protect hosts against helminthic infection but also mediate allergic disease. Here we show that nitric oxide (NO) promotes Th9 cell polarization of murine and human CD4+ T cells. NO de-represses the tumor suppressor gene p53 via nitrosylation of Mdm2. NO also increases p53-mediated IL-2 production, STAT5 phosphorylation and IRF4 expression, all essential for Th9 polarization. NO also increases the expression of TGFβR and IL-4R, pivotal to Th9 polarization. OVA-sensitized mice treated with an NO donor developed more severe airway inflammation. Transferred Th9 cells induced airway inflammation, which was exacerbated by NO and blocked by anti-IL-9 antibody. Nos2−/− mice had less Th9 cells and developed attenuated eosinophilia during OVA-induced airway inflammation compared to wild-type mice. Our data demonstrate that NO is an important endogenous inducer of Th9 cells and provide a hitherto unrecognized mechanism for NO-mediated airway inflammation via the expansion of Th9 cells. PMID:25099390

Cell Surface Galectin-9 Expressing Th Cells Regulate Th17 and Foxp3+ Treg Development by Galectin-9 Secretion

PubMed Central

Niki, Toshiro; Kadowaki, Takeshi; Ueno, Masaki; Nishi, Nozomu; Yamauchi, Akira; Hattori, Toshio; Masaki, Tsutomu; Hirashima, Mitsuomi

2012-01-01

Galectin-9 (Gal-9), a β-galactoside binding mammalian lectin, regulates immune responses by reducing pro-inflammatory IL-17-producing Th cells (Th17) and increasing anti-inflammatory Foxp3+ regulatory T cells (Treg) in vitro and in vivo. These functions of Gal-9 are thought to be exerted by binding to receptor molecules on the cell surface. However, Gal-9 lacks a signal peptide for secretion and is predominantly located in the cytoplasm, which raises questions regarding how and which cells secrete Gal-9 in vivo. Since Gal-9 expression does not necessarily correlate with its secretion, Gal-9-secreting cells in vivo have been elusive. We report here that CD4 T cells expressing Gal-9 on the cell surface (Gal-9+ Th cells) secrete Gal-9 upon T cell receptor (TCR) stimulation, but other CD4 T cells do not, although they express an equivalent amount of intracellular Gal-9. Gal-9+ Th cells expressed interleukin (IL)-10 and transforming growth factor (TGF)-β but did not express Foxp3. In a co-culture experiment, Gal-9+ Th cells regulated Th17/Treg development in a manner similar to that by exogenous Gal-9, during which the regulation by Gal-9+ Th cells was shown to be sensitive to a Gal-9 antagonist but insensitive to IL-10 and TGF-β blockades. Further elucidation of Gal-9+ Th cells in humans indicates a conserved role of these cells through evolution and implies the possible utility of these cells for diagnosis or treatment of immunological diseases. PMID:23144904

Numerical results on the transcendence of constants involving pi, e, and Euler's constant

NASA Technical Reports Server (NTRS)

Bailey, David H.

1988-01-01

The existence of simple polynomial equations (integer relations) for the constants e/pi, e + pi, log pi, gamma (Euler's constant), e exp gamma, gamma/e, gamma/pi, and log gamma is investigated by means of numerical computations. The recursive form of the Ferguson-Fourcade algorithm (Ferguson and Fourcade, 1979; Ferguson, 1986 and 1987) is implemented on the Cray-2 supercomputer at NASA Ames, applying multiprecision techniques similar to those described by Bailey (1988) except that FFTs are used instead of dual-prime-modulus transforms for multiplication. It is shown that none of the constants has an integer relation of degree eight or less with coefficients of Euclidean norm 10 to the 9th or less.

Experimental investigation of a 10-percent-thick helicopter rotor airfoil section designed with a viscous transonic analysis code

NASA Technical Reports Server (NTRS)

Noonan, K. W.

1981-01-01

An investigation was conducted in the Langley 6- by 28-Inch Transonic Tunnel to determine the two dimensional aerodynamic characteristics of a 10-percent-thick helicopter rotor airfoil at Mach numbers from 0.33 to 0.87 and respective Reynolds numbers from 4.9 x 10 to the 6th to 9.8 x 10 to the 6th. This airfoil, designated the RC-10(N)-1, was also investigated at Reynolds numbers from 3.0 x 10 to the 6th to 7.3 x 10 to the 6th at respective Mach numbers of 0.33 to 0.83 for comparison wit the SC 1095 (with tab) airfoil. The RC-10(N)-1 airfoil was designed by the use of a viscous transonic analysis code. The results of the investigation indicate that the RC-10(N)-1 airfoil met all the design goals. At a Reynolds number of about 9.4 x 10 to the 6th the drag divergence Mach number at zero normal-force coefficient was 0.815 with a corresponding pitching-moment coefficient of zero. The drag divergence Mach number at a normal-force coefficient of 0.9 and a Reynolds number of about 8.0 x 10 to the 6th was 0.61. The drag divergence Mach number of this new airfoil was higher than that of the SC 1095 airfoil at normal-force coefficients above 0.3. Measurements in the same wind tunnel at comparable Reynolds numbers indicated that the maximum normal-force coefficient of the RC-10(N)-1 airfoil was higher than that of the NACA 0012 airfoil for Mach numbers above about 0.35 and was about the same as that of the SC 1095 airfoil for Mach numbers up to 0.5.

PROTEIN NEEDS OF CRITICALLY ILL PATIENTS RECEIVING PARENTERAL NUTRITION.

PubMed

Germano Borges de Oliveira Nascimento Freitas, Renata; Negrão Nogueira, Roberto José; Hessel, Gabriel

2015-07-01

assess whether the current protein intake recommendations may improve the biochemical parameters of critical patients receiving parenteral nutrition. longitudinal study with three evaluations made (during the first 72 hours, on the 7th and the 14th days of PN). The following tests were applied: albumin, C-reactive protein, prealbumin, total cholesterol, HDL, triglycerides, lymphocytes, and glutathione peroxidase. The severity was determined by SOFA. The statistical analysis included the Spearman and Mann-Whitney tests, as well as ANOVA (analysis of variance). among the 53 patients evaluated, 20 (37.74%) died. The mean calorie was 24.68 ± 9.78 kcal/kg (beginning of PN), 26.49 ± 8.89 kcal/kg (3rd to 7th days of PN), and 30.9 ± 12.19 kcal/kg (7th to 14th days of PN). The mean protein was 1.19 ± 0.44 g/kcal/kg (first 72 hours of PN), 1.29 ± 0.44 g/kcal/kg (3rd to 7th days of PN) and 1.49 ± 0.69 g/kcal/kg (7th to 14th days of PN). Prealbumin, albumin, total cholesterol and HDL were below the reference values, while the CRP levels were high. Throughout the three evaluation times, there was no a significant improvement on the levels of laboratory examinations. A strong and negative correlation was found between SOFA and prealbumin (r = -0.64, p = 0.05). the protein offer, according to the traditional recommendations, was not enough to improve the biochemical parameters of critical patients undergoing parenteral nutrition. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Cytokine production in peripheral blood cells of patients with differentiated thyroid cancer: elevated Th2/Th9 cytokine production before and reduced Th2 cytokine production after radioactive iodine therapy.

PubMed

Simonovic, Snezana Zivancevic; Mihaljevic, Olgica; Majstorovic, Ivana; Djurdjevic, Predrag; Kostic, Irena; Djordjevic, Olivera Milosevic; Teodorovic, Ljiljana Mijatovic

2015-01-01

Cytokines play a key role in the regulation of cells of the immune system and also have been implicated in the pathogenesis of malignant diseases. The aim of this study was to evaluate cytokine profiles in patients with differentiated thyroid cancer (DTC) before and 7 days after radioactive iodine (131-I) therapy. Cytokine levels were determined in supernatants obtained from phytohemagglutinin-stimulated whole blood cultures of 13 patients with DTC and 13 control subjects. The concentrations of selected cytokines: Th1-interferon gamma (IFN-γ), interleukin 2 (IL-2) and tumor necrosis factor alpha (TNF-α); Th2-interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 13 (IL-13) and interleukin 10 (IL-10); Th9-interleukin-9 (IL-9); and Th17-interleukin 17 (IL-17A) were measured using multiplex cytokine detection systems for Human Th1/Th2/Th9/Th17/Th22. We have shown that peripheral blood cells of DTC patients produce significantly higher concentrations of Th2/Th9 cytokines (IL-5, IL-13 and IL-9) than control subjects. The 131-I therapy led to reduced secretion of Th2 cytokines (IL-4, IL-5 and IL-13). Despite this, the calculated cytokine ratios (Th1/Th2) in DTC patients before and 7 days after 131-I therapy were not different from those in healthy subjects. DTC patients have significantly higher concentrations of Th2/Th9 cytokines (IL-5, IL-13 and IL-9) than control subjects. There is no influence of hypothyroidism or stage of disease on cytokine production in DTC patients before 131-I therapy. The radioactive 131-I therapy leads to reduced secretion of Th2 cytokines (IL-4, IL-5 and IL-13). Additional studies are needed to determine the significance of these findings.

Sagittal and transversal plane deformity in thoracic scoliosis.

PubMed

Kotwicki, Tomasz

2002-01-01

The aim of the study was to assess the sagittal and transversal plane deformity of the spine in thoracic scoliosis by the mean of 3-D radiographic analysis. 46 patients admitted for surgery for thoracic idiopathic scoliosis underwent preoperative radiographic assessment. All patients presented the same pattern of the coronal plane deformity: single right thoracic curve (Lenke 1, King 3). Neither lumbar nor proximal thoracic structural curve were present. The Cobb angle varied from 41gamma to 77 gamma (mean 55,4 gamma +/- 8,6 gamma). Long cassette standing antero-posterior and lateral radiographs were analysed. Three-dimensional reconstruction with Rachis 91TM software was performed for each pair of radiographs. The following parameters were assessed: sagittal thoracic Cobb angle (Th4-Th12), upper thoracic kyphosis angle (Th5-Th8), lower thoracic kyphosis angle (Th9-Th12), superior and inferior hemi-curve sagittal angles, lumbar lordosis, sacral slope, sacral incidence, vertebral plate index, segmental vertebral axial rotation throughout the thoracic and lumbar spine. Results showed great variability of parameters assessed. The non-harmonious distribution of kyphosis was demonstrated in the thoracic spine. Local Th9-Th12 hypokyphosis and adjacent local Th5-Th8 hyperkyphosis constitute the most typical sagittal pathologies. So called normokyphotic curves were composed of one hyperkyphotic and one hypokyphotic zone. Th1-Th4 segment revealed two patterns of segmental rotation distribution: a purely compensatory curve with no vertebral axial rotation or a rotated curve presenting the morphology intermediate between Lenke 1 and Lenke 2 types (or King 3 and King 5). curves presenting the same coronal plane deformity differ in their morphology assessed in the two other planes; global thoracic kyphosis angle is a misleading parameter because it covers hypo- and hyperkyphotic zones; local distal thoracic (Th9-Th12) hypokyphosis is present in idiopathic thoracic scoliosis.

Development of a Linearized Unsteady Euler Analysis with Application to Wake/Blade-Row Interactions

NASA Technical Reports Server (NTRS)

Verdon, Joseph M.; Montgomery, Matthew D.; Chuang, H. Andrew

1999-01-01

A three-dimensional, linearized, Euler analysis is being developed to provide a comprehensive and efficient unsteady aerodynamic analysis for predicting the aeroacoustic and aeroelastic responses of axial-flow turbomachinery blading. The mathematical models needed to describe nonlinear and linearized, inviscid, unsteady flows through a blade row operating within a cylindrical annular duct are presented in this report. A numerical model for linearized inviscid unsteady flows, which couples a near-field, implicit, wave-split, finite volume analysis to far-field eigen analyses, is also described. The linearized aerodynamic and numerical models have been implemented into the three-dimensional unsteady flow code, LINFLUX. This code is applied herein to predict unsteady subsonic flows driven by wake or vortical excitations. The intent is to validate the LINFLUX analysis via numerical results for simple benchmark unsteady flows and to demonstrate this analysis via application to a realistic wake/blade-row interaction. Detailed numerical results for a three-dimensional version of the 10th Standard Cascade and a fan exit guide vane indicate that LINFLUX is becoming a reliable and useful unsteady aerodynamic prediction capability that can be applied, in the future, to assess the three-dimensional flow physics important to blade-row, aeroacoustic and aeroelastic responses.

Parent-Child Acculturation Patterns and Substance Use among Hispanic Adolescents: A Longitudinal Analysis

ERIC Educational Resources Information Center

Unger, Jennifer B.; Ritt-Olson, Anamara; Wagner, Karla D.; Soto, Daniel W.; Baezconde-Garbanati, Lourdes

2009-01-01

Acculturation discrepancy theory predicts that conflicting cultural preferences between adolescents and their parents will increase the adolescents' risk for behavior problems such as substance use. This study evaluated this hypothesis in a sample of 1683 Hispanic students in Southern California who completed surveys in 9th and 10th grade.…

Longitudinal Analysis of Links between Bullying Victimization and Psychosomatic Maladjustment in Swedish Schoolchildren

ERIC Educational Resources Information Center

Hellfeldt, Karin; Gill, Peter Edward; Johansson, Björn

2018-01-01

Cross-sectional studies of bullying mask variability in categories of and persistence of bullying victimization. Longitudinal, individual-level data offers a greater insight into schoolchildren's psychosomatic maladjustment as a consequence of bullying. Swedish schoolchildren (n = 3,349), with unique identifiers, in 44 schools (4th-9th grade),…

Review of "The September 11th Education Program: A National Interdisciplinary Curriculum"

ERIC Educational Resources Information Center

Waterson, Robert A.; Jenne, Katherine

2011-01-01

A review of "The September 11th Education Program: A National Interdisciplinary Curriculum" reveals a sensitive and well-created program for the 5-12 social studies teacher to use in teaching about the challenging subject of 9/11. This program provides an opportunity for teachers to find a balance among understanding, critical analysis,…

Quality of Teaching and Dropout Risk: A Multi-Level Analysis

ERIC Educational Resources Information Center

Magen-Nagar, Noga; Shachar, Hanna

2017-01-01

The purpose of this study is to examine how the quality of teaching contributes to a sense of belonging and satisfaction, while considering students' personal and socioeconomic variables, in explaining the risk of dropping out of school. Two thousand, eight hundred and seventy 4th- to 9th-grade students from 105 classes in 18 schools participated…

Modeling the Relations among Parental Involvement, School Engagement and Academic Performance of High School Students

ERIC Educational Resources Information Center

Al-Alwan, Ahmed F.

2014-01-01

The author proposed a model to explain how parental involvement and school engagement related to academic performance. Participants were (671) 9th and 10th graders students who completed two scales of "parental involvement" and "school engagement" in their regular classrooms. Results of the path analysis suggested that the…

MyPyramid.gov knowledge and access among rural southwest Mississippi African American adolescents

USDA-ARS?s Scientific Manuscript database

This study used a qualitative approach to identify knowledge of food recommendations found on MyPyramid.gov and access to MyPyramid.gov among limited-income African American youth. We conducted 5 single-sex focus groups with 9 boys and 30 girls (grades 5th and 6th). Data processing and analysis incl...

Using 4th order Runge-Kutta method for solving a twisted Skyrme string equation

NASA Astrophysics Data System (ADS)

Hadi, Miftachul; Anderson, Malcolm; Husein, Andri

2016-03-01

We study numerical solution, especially using 4th order Runge-Kutta method, for solving a twisted Skyrme string equation. We find numerically that the value of minimum energy per unit length of vortex solution for a twisted Skyrmion string is 20.37 × 1060 eV/m.

Numerical modelling of river morphodynamics: Latest developments and remaining challenges

NASA Astrophysics Data System (ADS)

Siviglia, Annunziato; Crosato, Alessandra

2016-07-01

Numerical morphodynamic models provide scientific frameworks for advancing our understanding of river systems. The research on involved topics is an important and socially relevant undertaking regarding our environment. Nowadays numerical models are used for different purposes, from answering questions about basic morphodynamic research to managing complex river engineering problems. Due to increasing computer power and the development of advanced numerical techniques, morphodynamic models are now more and more used to predict the bed patterns evolution to a broad spectrum of spatial and temporal scales. The development and the success of application of such models are based upon a wide range of disciplines from applied mathematics for the numerical solution of the equations to geomorphology for the physical interpretation of the results. In this light we organized this special issue (SI) soliciting multidisciplinary contributions which encompass any aspect needed for the development and applications of such models. Most of the papers in the SI stem from contributions to session HS9.5/GM7.11 on numerical modelling and experiments in river morphodynamics at the European Geosciences Union (EGU) General Assembly held in Vienna, April 27th to May 2nd 2014.

Three-Dimensional Transient Natural Convection in a Horizontal Cylinder: A Numerical Analysis

DTIC Science & Technology

1980-02-01

A11D 03 _________ 14. MNITORNG AGNCY AME&AORESS(it different from Controlling Office) IS. SECURITY CLASS. (of this report) -~Th /UNCLASSIFIED AISa . OECL...method for the vorticity and - DD IjANඑ 1473 EDITION OF I NOV6 SS OBSOLETE UNCLASSIFIED SECURITY CLASSIFICATION Of THIS PACE,n bt. Nte, -’ ’..r&IeI

Annual Adult Education Research Conference. Proceedings (20th, Ann Arbor, Michigan, April 4-6, 1979).

ERIC Educational Resources Information Center

1979

Papers from numerous research areas in the adult education field are presented. The proceedings contain thirty-five papers, five symposia, one alternate symposium, and eighteen alternate papers. Among the papers included are "A Comparison of Approaches to Measuring Outcomes in Adult Basic Education,""A Critical Analysis of Hill's…

Analysis of heat-transfer measurements from 2 AEDC wind tunnels on the Shuttle external tank

NASA Technical Reports Server (NTRS)

Nutt, K. W.

1984-01-01

Previous aerodynamic heating tests have been conducted in the AEDC/VKF Supersonic Wind Tunnel (A) to aid in defining the design thermal environment for the space shuttle external tank. The quality of these data has been under discussion because of the effects of low tunnel enthalpy and slow model injection rates. Recently the AEDC/VKF Hypersonic Wind Tunnel (C) has been modified to provide a Mach 4 capability that has significantly higher tunnel enthalpy with more rapid model injection rates. Tests were conducted in Tunnel C at Mach 4 to obtain data on the external tank for comparison with Tunnel A results. Data were obtained on a 0.0175 scale model of the Space Shuttle Integrated Vehicle at Re/ft = 4 x 10 to the 6th power with the tunnel stagnation temperature varying from 740 to 1440 R. Model attitude varied from an angle of attack of -5 to 5 deg and an angle of sideslip of -3 to 3 deg. One set of data was obtained in Tunnel C at Re/ft = 6.9 x 10 to the 6th for comparison with flight data. Data comparisons between the two tunnels for numerous regions on the external tank are given.

Fine motor skill proficiency in typically developing children: On or off the maturation track?

PubMed

Gaul, David; Issartel, Johann

2016-04-01

Fine motor skill proficiency is an essential component of numerous daily living activities such as dressing, feeding or playing. Poor fine motor skills can lead to difficulties in academic achievement, increased anxiety and poor self-esteem. Recent findings have shown that children's gross motor skill proficiency tends to fall below established developmental norms. A question remains: do fine motor skill proficiency levels also fall below developmental norms? The aim of this study was to examine the current level of fine motor skill in Irish children. Children (N=253) from 2nd, 4th and 6th grades (mean age=7.12, 9.11 and 11.02 respectively) completed the Fine Motor Composite of the Bruininks Oseretsky Test of Motor Proficiency 2nd Edition (BOT-2). Analysis revealed that only 2nd grade children met the expected level of fine motor skill proficiency. It was also found that despite children's raw scores improving with age, children's fine motor skill proficiency was not progressing at the expected rate given by normative data. This leads us to question the role and impact of modern society on fine motor skills development over the past number of decades. Copyright © 2015 Elsevier B.V. All rights reserved.

Th9 cytokines response and its possible implications in the immunopathogenesis of leprosy.

PubMed

de Sousa, Jorge Rodrigues; Pagliari, Carla; de Almeida, Dandara Simone Maia; Barros, Luiz Fernando Lima; Carneiro, Francisca Regina Oliveira; Dias, Leonidas Braga; de Souza Aarão, Tinara Leila; Quaresma, Juarez Antonio Simões

2017-06-01

Leprosy is an infectious-contagious disease whose clinical evolution depends on the interaction of the infectious agent with the immune response of the host, leading to a clinical spectrum that ranges from lepromatous leprosy (susceptibility, LL) to tuberculoid leprosy (resistance, TT). The immune response profile will depend on the pattern of cytokine production and on the activity of macrophages during infection. Classically, the clinical evolution of leprosy has been associated with Th1/Th2 cytokine profiles, but the role of new cytokine profiles such as T helper 9 (Th9) remains to be elucidated. To evaluate the tissue expression profile of these cytokines, a cross-sectional study was conducted using a sample of 30 leprosy skin lesion biopsies obtained from patients with leprosy, 16 TT and 14 lepromatous LL. Immunohistochemical analysis revealed a significant difference in interleukin (IL)-9, IL-4 transforming growth factor (TGF)-β and IL-10 levels between the two groups. IL-9 was more expressed in TT lesions compared with LL lesions. Higher expression of IL-4, IL-10 and TGF-β was observed in LL compared with TT. IL-4, IL-10 and TGF-β tended to be negatively correlated with the expression of IL-9, indicating a possible antagonistic activity in tissue. The results suggest that Th9 lymphocytes may be involved in the response to Mycobacterium leprae , positively or negatively regulating microbicidal activity of the local immune system in the disease. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Longitudinal Model Building Using Latent Transition Analysis: An Example Using School Bullying Data.

PubMed

Ryoo, Ji Hoon; Wang, Cixin; Swearer, Susan M; Hull, Michael; Shi, Dingjing

2018-01-01

Applications of latent transition analysis (LTA) have emerged since the early 1990s, with numerous scientific findings being published in many areas, including social and behavioral sciences, education, and public health. Although LTA is effective as a statistical analytic tool for a person-centered model using longitudinal data, model building in LTA has often been subjective and confusing for applied researchers. To fill this gap in the literature, we review the components of LTA, recommend a framework of fitting LTA, and summarize what acceptable model evaluation tools should be used in practice. The proposed framework of fitting LTA consists of six steps depicted in Figure 1 from step 0 (exploring data) to step 5 (fitting distal variables). We also illustrate the framework of fitting LTA with data on concerns about school bullying from a sample of 1,180 students ranging from 5th to 9th grade (mean age = 12.2 years, SD = 1.29 years at Time 1) over three semesters. We identified four groups of students with distinct patterns of bullying concerns, and found that their concerns about bullying decreased and narrowed to specific concerns about rumors, gossip, and social exclusion over time. The data and command (syntax) files needed for reproducing the results using SAS PROC LCA and PROC LTA (Version 1.3.2) (2015) and Mplus 7.4 (Muthén and Muthén, 1998-2015) are provided as online supplementary materials.

Structural study of dehydration mechanisms of NH4Th(NO3)5·9H2O

NASA Astrophysics Data System (ADS)

Knyazev, A. V.; Komshina, M. E.; Baranov, E. V.; Savushkin, I. A.; Nipruk, O. V.; Lukoyanov, A. Yu.

2017-12-01

The new pentanitrate thorium compounds NH4Th(NO3)5·nH2O were synthesized and their crystal structures were determined by X-ray diffraction analysis: space group P21/n, a = 10.5476(5), b = 14.0444(7), c = 15.5287(8) Å, β = 109.4999(7)°, Z = 4; R = 0.0246 (NH4Th(NO3)5·9H2O); space group P212121, a = 8.7039(4), b = 11.9985(6), c = 16.3531(8) Å, Z = 4; R = 0.0259 (NH4Th(NO3)5·5H2O). Features of structural changes in the dehydration were revealed. Conditions of thermal decomposition of the thorium compound were established using differential scanning calorimetry. The compound was investigated by IR spectroscopy and its bands are assigned.

Targeting innate immunity for neurodegenerative disorders of the central nervous system.

PubMed

Andreasson, Katrin I; Bachstetter, Adam D; Colonna, Marco; Ginhoux, Florent; Holmes, Clive; Lamb, Bruce; Landreth, Gary; Lee, Daniel C; Low, Donovan; Lynch, Marina A; Monsonego, Alon; O'Banion, M Kerry; Pekny, Milos; Puschmann, Till; Russek-Blum, Niva; Sandusky, Leslie A; Selenica, Maj-Linda B; Takata, Kazuyuki; Teeling, Jessica; Town, Terrence; Van Eldik, Linda J

2016-09-01

Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview of physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia and astrocyte cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article. Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer's disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview on physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article. © 2016 International Society for Neurochemistry.

Morphology and Prevalence Study of Lumbar Scoliosis in 7,075 Multiracial Asian Adults.

PubMed

Liu, Gabriel; Tan, Jun Hao; Ee, Gerard; Chan, Yiong Huak; Low, Siew Leng; Wong, Hee-Kit

2016-08-03

Lumbar scoliosis affects patients' quality of life and will increasingly burden the health-care system as the population ages, yet there have been few reports of its prevalence in Asians. The aim of this study was to identify the prevalence of scoliosis, curve characteristics, and risk factors for development of scoliosis in an Asian population. A retrospective cross-sectional study was conducted using spinal images obtained from dual x-ray absorptiometry (DXA) scans of individuals ≥40 years of age. Scoliosis was defined as a curvature of >10°. A multivariate analysis for risk factors for development of lumbar scoliosis was performed. Of 7,075 patients studied, 645 (9.1%) were identified as having scoliosis. The average age of the patients with scoliosis was 61 years (range, 40 to 98 years). The mean curve prevalence was 9.4% in women and 6.5% in men. The average Cobb angle was 16.5° (range, 10° to 66°). Multivariate analysis showed an increased risk of scoliosis in women (relative risk [RR] = 2.4, 95% CI =1.4 to 4.3), Chinese patients (RR = 2.4, 95% CI = 1.4 to 4.3), Malay patients (RR = 2.5, 95% CI = 1.3 to 4.9), and patients with spinal fracture (RR = 5.1, 95% CI = 3.0 to 8.8). The risk of scoliosis was found to increase as patients progressed through each decade of life after the age of 40 years (6th decade: RR = 1.6, 95% CI = 1.1 to 2.4, p = 0.026; 7th decade: RR = 2.7, 95% CI = 1.8 to 4.1, p < 0.001; 8th decade: RR = 5.0, 95% CI = 3.2 to 7.9, p < 0.001; and 9th decade: RR = 8.8, 95% CI = 4.3 to 17.9, p < 0.001). The prevalence of lumbar scoliosis in Asian adults was found to be 9.1%. A nearly exponential increase in scoliosis prevalence from the 5th decade of life (4%) to the ≥9th decade (25%) and a majority of left-sided scoliotic curves, measuring between 10° and 19° with an L2 apex, was found. Older age, female sex, Chinese or Malay race, and vertebral fracture increased the risk of scoliosis developing. Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence. Copyright © 2016 by The Journal of Bone and Joint Surgery, Incorporated.

77 FR 4858 - Culturally Significant Objects Imported for Exhibition Determinations: “Byzantium and Islam: Age...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-31

... Determinations: ``Byzantium and Islam: Age of Transition (7th-9th Century)'' AGENCY: Department of State. ACTION... to the exhibition ``Byzantium and Islam: Age of Transition (7th-9th Century). The referenced notice... objects to be included in the exhibition ``Byzantium and Islam: Age of Transition (7th-9th Century...

Exploring new possibilities of astronomy education and outreach

NASA Astrophysics Data System (ADS)

Fukushima, Kodai

2015-08-01

I investigate the influences of astronomy education and outreach activities on people in order to explore their potential benefits and contribution to society. This research is based on the astronomy education lessons I gave to 287 senior high school and junior high school students in Cambodia in November 2013. Before and after my lesson, I asked them to answer my questionnaires in Khmer, where they could also write free descriptions. Sentences in their free descriptions translated into Japanese are analyzed by means of a text mining method. By converting text data to various numbers using a text mining method, it is possible for us to do statistical analysis. I counted the number of question sentences and computed their rate with respect to the total number of sentences. The rate of question sentences in 9th and 12th grade students are 39% and 9%, respectively. This shows 9th grade students wonder why and how more frequently and appear to be more stimulated in their curiosity than 12th grade students. I counted the frequency of words in the free descriptions and examined high frequency words, to take a broad view of the characteristics of free description. The word ''world'' is the fourth highest frequency word among 369 words following the three words, ''the universe'', ''the earth'', and ''a star'', which frequently appear in the lesson in astronomy. The most sentences including the word “world” described amazement at the existence of so vast unknown world outside of what they had known until then. The frequency of sentences including the word ''world'' of 12th grade students is much higher (45%) than that (18%) of 9th grade students. A significant fraction of 12th grade students appears to have had a strong impact and changed their views of the world. It is found that my lesson and related activities inspired intellectual curiosity in many students, especially in 9th grade students. It is also found that a significant fraction of 12th grade students appear to have had a strong impact and changed their views of the world. I conclude that astronomy education and outreach activities have a potential to contribute to Cambodian development.

Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings

PubMed Central

He, Mengzhou; Jiang, Ming; Zhou, Yuan; Li, Fanfan; Yang, Meitao; Fan, Yao; Xie, Yin; Beejadhursing, Rajluxmee; Feng, Ling

2018-01-01

Recurrent miscarriage is defined as the loss of 3 or more consecutive pregnancies; however, the underlying immunologic mechanisms that trigger pregnancy loss remain largely unelucidated. Galectin-9 (Gal-9) may modulate a variety of biologic functions and play an important role in Th1/Th2 immune deviation. To analyze the mechanism of Gal-9 in abortion, we used the classical abortion-prone mouse model (DBA/2-mated CBA/J mice) to detect the expression of Gal-9 at the maternal-fetal interface. We also mimicked the immune environment of pregnancy by culturing trophoblast cells with peripheral blood mononuclear cells (PBMCs) to explore how Gal-9 might be involved in the pathogenesis of abortion. We found that the expression levels of Gal-9 in abortion-prone matings were lower than that for controls. Using a coculture system, we detected a Th1 preponderance in the coculture from abortion-prone matings. Furthermore, Gal-9 blockade augmented the imbalance of Th1/Th2 immunity in abortion-prone matings by promoting the secretion of Th1-derived cytokines in coculture, while there was a Th2 preponderance when we administered recombinant Gal-9. In conclusion, our results suggest that the Gal-9 signal is important for the regulation of PBMC function toward a Th2 bias at the maternal-fetal interface, which is beneficial for the maintenance of a normal pregnancy. PMID:29651447

50-500 MeV observations of LMC supernova 1987A

NASA Astrophysics Data System (ADS)

Summer, T. J.; Rochester, G. K.; Sood, R. K.; Thomas, J.; Waldron, L.; Manchanda, R. K.; Frye, G.; Jenkins, T.; Koga, R.; Staubert, R.; Kendziorra, E.; Ubertini, P.; Bazzano, A.; La Padula, C.

Since the discovery of the supernova outburst in the LMC in 1987, two attempts (on day 55 and day 407) have been made to measure the high energy gamma-ray flux in the range 50-500 MeV, by using a balloon-borne spark chamber telescope. On day 55, no positive signal was seen from the source. A 3 sigma upper limit of 2.9 x 10 to the -5th ph/sq cm s was obtained after the analysis of the spark chamber data. Preliminary analysis of the quick look data obtained in the second flight shows that the gamma-ray flux even on day 407 was less than 9 x 10 to the -4th ph/sq cm s (3 sigma).

A Research on High School Students' Concepts of "Erosion" by Using Phenomenographic Analysis

ERIC Educational Resources Information Center

Ates, Murat

2013-01-01

The purpose of this research is to define and explain how high school students in Turkey perceive the concept of "erosion" by using phenomenographic research methods. The research group of the study is comprised of 450 high school students studying in 9th to 12th grades. In this research, there are some expressions gathered from…

Cytokine production in patients with papillary thyroid cancer and associated autoimmune Hashimoto thyroiditis.

PubMed

Zivancevic-Simonovic, Snezana; Mihaljevic, Olgica; Majstorovic, Ivana; Popovic, Suzana; Markovic, Slavica; Milosevic-Djordjevic, Olivera; Jovanovic, Zorica; Mijatovic-Teodorovic, Ljiljana; Mihajlovic, Dusan; Colic, Miodrag

2015-08-01

Hashimoto thyroiditis (HT) is the most frequent thyroid autoimmune disease, while papillary thyroid cancer (PTC) is one of the most common endocrine malignancies. A few patients with HT also develop PTC. The aim of this study was to analyze cytokine profiles in patients with PTC accompanied with autoimmune HT in comparison with those in patients with PTC alone or HT alone and healthy subjects. Cytokine levels were determined in supernatants obtained from phytohemagglutinin (PHA)-stimulated whole blood cultures in vitro. The concentrations of selected cytokines: Th1-interferon gamma (IFN-γ); Th2-interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL-6), interleukin 10 (IL-10) and interleukin 13 (IL-13); Th9-interleukin 9 (IL-9); and Th17-interleukin 17 (IL-17A) were measured using multiplex cytokine detection systems for human Th1/Th2/Th9/Th17/Th22. We found that PTC patients with HT produced significantly higher concentrations of IL-4, IL-6, IL-9, IL-13 and IFN-γ than PTC patients without HT. In conclusion, autoimmune HT affects the cytokine profile of patients with PTC by stimulating secretion of Th1/Th2/Th9 types of cytokines. Th1/Th2 cytokine ratios in PTC patients with associated autoimmune HT indicate a marked shift toward Th2 immunity.

MPCV Exercise Operational Volume Analysis

NASA Technical Reports Server (NTRS)

Godfrey, A.; Humphreys, B.; Funk, J.; Perusek, G.; Lewandowski, B. E.

2017-01-01

In order to minimize the loss of bone and muscle mass during spaceflight, the Multi-purpose Crew Vehicle (MPCV) will include an exercise device and enough free space within the cabin for astronauts to use the device effectively. The NASA Digital Astronaut Project (DAP) has been tasked with using computational modeling to aid in determining whether or not the available operational volume is sufficient for in-flight exercise.Motion capture data was acquired using a 12-camera Smart DX system (BTS Bioengineering, Brooklyn, NY), while exercisers performed 9 resistive exercises without volume restrictions in a 1g environment. Data were collected from two male subjects, one being in the 99th percentile of height and the other in the 50th percentile of height, using between 25 and 60 motion capture markers. Motion capture data was also recorded as a third subject, also near the 50th percentile in height, performed aerobic rowing during a parabolic flight. A motion capture system and algorithms developed previously and presented at last years HRP-IWS were utilized to collect and process the data from the parabolic flight [1]. These motions were applied to a scaled version of a biomechanical model within the biomechanical modeling software OpenSim [2], and the volume sweeps of the motions were visually assessed against an imported CAD model of the operational volume. Further numerical analysis was performed using Matlab (Mathworks, Natick, MA) and the OpenSim API. This analysis determined the location of every marker in space over the duration of the exercise motion, and the distance of each marker to the nearest surface of the volume. Containment of the exercise motions within the operational volume was determined on a per-exercise and per-subject basis. The orientation of the exerciser and the angle of the footplate were two important factors upon which containment was dependent. Regions where the exercise motion exceeds the bounds of the operational volume have been identified by determining which markers from the motion capture exceed the operational volume and by how much. A credibility assessment of this analysis was performed in accordance with NASA-STD-7009 prior to delivery to the MPCV program.

Th9 cells: differentiation and disease

PubMed Central

Kaplan, Mark H.

2014-01-01

Summary CD4+ T-helper cells regulate immunity and inflammation through the acquisition of potential to secrete specific cytokines. The acquisition of cytokine-secreting potential, in a process termed T-helper cell differentiation, is a response to multiple environmental signals including the cytokine milieu. The most recently defined subset of T-helper cells are termed Th9 and are identified by the potent production of interleukin-9 (IL-9). Given the pleiotropic functions of IL-9, Th9 cells might be involved in pathogen immunity and immune-mediated disease. In this review, I focus on recent developments in understanding the signals that promote Th9 differentiation, the transcription factors that regulate IL-9 expression, and finally the potential roles for Th9 cells in immunity in vivo. PMID:23405898

Increased Th9 cells and IL-9 levels accelerate disease progression in experimental atherosclerosis.

PubMed

Li, Qing; Ming, Tingting; Wang, Yuanmin; Ding, Shaowei; Hu, Chaojie; Zhang, Cuiping; Cao, Qi; Wang, Yiping

2017-01-01

Atherosclerosis (AS) is the number one killer in developed countries, and currently considered a chronic inflammatory disease. The central role of T cells in the pathogenesis of atherosclerosis is well documented. However, little is known about the newly described T cell subset-Th9 cells and their role in AS pathogenesis. Here, the amounts of Th9 cells as well as their key transcription factors and relevant cytokines during atherosclerosis were assessed in ApoE -/- mice and age-matched C57BL/6J mice. Significantly increased Th9 cell number, Th9 related cytokine (IL-9), and key transcription factor (PU.1) were found in ApoE -/- mice compared with age-matched C57BL/6J mice. Additionally, treatment with rIL-9 accelerated atherosclerotic development, which was attenuated by anti-IL-9 antibodies. These data suggested that both Th9 cells and related IL-9 play key roles in the pathogenesis of atherosclerosis, and antibodies against these antigens offer a novel therapeutic approach in AS treatment.

Correlations among Five Demographic Variables and the Performance of Selected Jamaican 11th-Graders on Some Numerical Problems on Energy

ERIC Educational Resources Information Center

Emepue, Nicholas; Soyibo, Kola

2009-01-01

This study was designed to assess whether the level of performance of selected Jamaican 11th-grade physics students on some numerical problems on the energy concept was satisfactory and if there were significant differences in their performance linked to their gender, socioeconomic background (SEB), school location, English language and…

SU-E-T-466: Dosimetric Assessment of the Salivary Glands in Head and Neck Tumour Patients Treated with Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peixoto, Xavier C; Costa, Ferreira B; Khouri, L

2014-06-01

Purpose: To estimate the correlation between different dosimetric indices and the clinical outcome, which was recorded at different time points after the treatment, regarding the structure of salivary glands in head and neck cancer radiotherapy. Methods: 218 salivary glands from patients with head and neck tumours treated at IPOCFG from 2007 to 2013 were included in this study. The follow up of those patients consisted on weekly medical visits during the treatment that take about seven weeks. After that the patients had consults every three months. Treatment complications were graded using the RTOG/EORTC guidelines. The response of the salivary glandsmore » (both parotids, oral cavity and both submandibular glands) was analyzed for six time periods: 7th week, 3rd, 7th, 12th, 18th and 24th months after the start of the radiotherapy. The total dose distributions, converted to a fractionation scheme of 2Gy fractional doses, were used to calculate the DVHs and dose-response plots of salivary glands. Results: The small differences obtained between the mean DVHs showed that patients should be grouped into: with complications (G1+G2) and without complications (G0). The mean dose/2Gy was 22.2±13.2 Gy (G0) and 33.2±8.0 Gy (G1+G2) for the 7th week, 31.9±9.6 Gy (G0) and 34.6±6.8 Gy (G1+G2) for the 12th month and, 32.9±9.3 Gy (G0) and 37.2±8.5 Gy (G1+G2) for the 24th month. The dose-response plots for the 7th week and 24th month were similar to the dose-response curves published in the literature. Conclusion: In some cases, there were not major differences between the mean DVHs of the groups with and without complications in the salivary glands, when comparing them at different time periods. More radiobiological analysis should thus be made to estimate the clinical impact of those differences.« less

SU-E-T-467: Definition of the Proper Tolerances for Beam-Position Accuracy and Beam Width for Quality Assurance in Active Proton Pencil Beam Scanning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Safai, S

2014-06-01

Purpose: To estimate the correlation between different dosimetric indices and the clinical outcome, which was recorded at different time points after the treatment, regarding the structure of salivary glands in head and neck cancer radiotherapy. Methods: 218 salivary glands from patients with head and neck tumours treated at IPOCFG from 2007 to 2013 were included in this study. The follow up of those patients consisted on weekly medical visits during the treatment that take about seven weeks. After that the patients had consults every three months. Treatment complications were graded using the RTOG/EORTC guidelines. The response of the salivary glandsmore » (both parotids, oral cavity and both submandibular glands) was analyzed for six time periods: 7th week, 3rd, 7th, 12th, 18th and 24th months after the start of the radiotherapy. The total dose distributions, converted to a fractionation scheme of 2Gy fractional doses, were used to calculate the DVHs and dose-response plots of salivary glands. Results: The small differences obtained between the mean DVHs showed that patients should be grouped into: with complications (G1+G2) and without complications (G0). The mean dose/2Gy was 22.2±13.2 Gy (G0) and 33.2±8.0 Gy (G1+G2) for the 7th week, 31.9±9.6 Gy (G0) and 34.6±6.8 Gy (G1+G2) for the 12th month and, 32.9±9.3 Gy (G0) and 37.2±8.5 Gy (G1+G2) for the 24th month. The dose-response plots for the 7th week and 24th month were similar to the dose-response curves published in the literature. Conclusion: In some cases, there were not major differences between the mean DVHs of the groups with and without complications in the salivary glands, when comparing them at different time periods. More radiobiological analysis should thus be made to estimate the clinical impact of those differences.« less

Types of injuries among Polish soldiers and civilian staff in the 7th, 8th, 9th and 10th rotation of the Afghan stabilization mission.

PubMed

Ziemba, Radosław

2012-03-01

The Afghan military theatre is specifically marked by guerilla operations and massive use of IEDs (improvised explosive devices) that pose new types of threats for their victims. At the same time, the relevant literature contains only a single, fragmentary analysis on injuries suffered by soldiers serving in the Afghan mission. This is a review of medical reports of the Polish Military Contingent deployed within Operation Enduring Freedom, from 1 January 2010 to 31 December 2011; the analysis includes all cases of combat and non-combat injuries in terms of their causes. In the period under analysis, 380 Polish soldiers were reported injured; 87.1% of cases were combat and 12.9% non-combat injuries. The structure of injuries caused as a result of IED explosions was dominated by multiple limb injuries, associated most frequently with severe body cavities/spine injuries. In the case of other incidents, both combat and non-combat, the predominant consequences were single and, most commonly, less severe injuries. The average number of injuries suffered from IED attacks (3.37) was significantly higher than the number of injuries from other attacks (1.16), and higher than the number of non-combat injuries (1.43). IED attacks pose a serious medical problem, considering their high number and the severity of injuries they cause.

Cross-Conjugated Nanoarchitectures

DTIC Science & Technology

2013-08-23

compounds were further evaluated by Lippert –Mataga analysis of the fluorescence solvatochromism and measurement of quantum yields and fluorescence...1.9 1.1 A(mP)2A Cy 0.49 5.5 0.90 0.93 D(Th)2D Cy 0.008 1.1 0.07 9 A(Th)2A Tol 0.014 2.1f 0.07 4.7 a Calculated from Lippert –Mataga plots for...Δfʹ region of the Lippert –Mataga plot. d Double exponential fit: τ1 = 21.5 ns (73%) and τ2 = 3.7 ns (27%). e Double exponential fit: τ1 = 0.85 ns

Empirical radiation belt models: Comparison with in situ data and implications for environment definition

NASA Astrophysics Data System (ADS)

de Soria-Santacruz Pich, Maria; Jun, Insoo; Evans, Robin

2017-09-01

The empirical AP8/AE8 model has been the de facto Earth's radiation belts engineering reference for decades. The need from the community for a better model incubated the development of AP9/AE9/SPM, which addresses several shortcomings of the old model. We provide additional validation of AP9/AE9 by comparing in situ electron and proton data from Jason-2, Polar Orbiting Environmental Satellites (POES), and the Van Allen Probes spacecraft with the 5th, 50th, and 95th percentiles from AE9/AP9 and with the model outputs from AE8/AP8. The relatively short duration of Van Allen Probes and Jason-2 missions means that their measurements are most certainly the result of specific climatological conditions. In low Earth orbit (LEO), the Jason-2 proton flux is better reproduced by AP8 compared to AP9, while the POES electron data are well enveloped by AE9 5th and 95th percentiles. The shape of the South Atlantic anomaly (SAA) from Jason-2 data is better captured by AP9 compared to AP8, while the peak SAA flux is better reproduced by AP8. The <1.5 MeV inner belt electrons from Magnetic Electron Ion Spectrometer (MagEIS) are well enveloped by AE9 5th and 95th percentiles, while AE8 overpredicts the measurements. In the outer radiation belt, MagEIS and Relativistic Electron and Proton Telescope (REPT) electrons closely follow the median estimate from AE9, while AP9 5th and 95th percentiles generally envelope REPT proton measurements in the inner belt and slot regions. While AE9/AP9 offer the flexibility to specify the environment with different confidence levels, the dose and trapped proton peak flux for POES and Jason-2 trajectories from the AE9/AP9 50th percentile and above are larger than the estimates from the AE8/AP8 models.

Evaluation of a Field-Portable DNA Microarray Platform and Nucleic Acid Amplification Strategies for the Detection of Arboviruses, Arthropods, and Bloodmeals

DTIC Science & Technology

2013-01-01

heparin was purchased from Innovative Research (Novi, MI). Goat and horse whole blood was provided by our Veterinary Medicine Division (USAMRIID, Fort...quinquefasciatus (10) BA House NA Human Culex Th9-0122 Ae. aegypti (1) BA House DENV-3 DNP Aedes Th9-0164 Cx. tritaeniorhynchus (24) LT Farm JEV NA...Culex Th9-0167 Ae. albopictus (1) LT Farm NA NA Aedes Th9-0175 Cx. tritaeniorhynchus (25) LT Farm JEV NA Culex Th9-0235 Cx. tritaeniorhynchus (25) BA

26 CFR 1.6074-1 - Time and place for filing declarations of estimated income tax by corporations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... shall be filed on or before the 15th day of the 9th month of such year by every corporation whose then... month of the taxable year after the last day of the 5th month and before the 1st day of the 9th month of the taxable year the 15th day of the 9th month of the taxable year after the last day of the 8th month...

PyVCI: A flexible open-source code for calculating accurate molecular infrared spectra

NASA Astrophysics Data System (ADS)

Sibaev, Marat; Crittenden, Deborah L.

2016-06-01

The PyVCI program package is a general purpose open-source code for simulating accurate molecular spectra, based upon force field expansions of the potential energy surface in normal mode coordinates. It includes harmonic normal coordinate analysis and vibrational configuration interaction (VCI) algorithms, implemented primarily in Python for accessibility but with time-consuming routines written in C. Coriolis coupling terms may be optionally included in the vibrational Hamiltonian. Non-negligible VCI matrix elements are stored in sparse matrix format to alleviate the diagonalization problem. CPU and memory requirements may be further controlled by algorithmic choices and/or numerical screening procedures, and recommended values are established by benchmarking using a test set of 44 molecules for which accurate analytical potential energy surfaces are available. Force fields in normal mode coordinates are obtained from the PyPES library of high quality analytical potential energy surfaces (to 6th order) or by numerical differentiation of analytic second derivatives generated using the GAMESS quantum chemical program package (to 4th order).

Content Analysis of Essays from a Cross-National Survey: Implications for Teaching Strategies in Holocaust Studies.

ERIC Educational Resources Information Center

McRoy, James J.

The content of essays written by randomly selected samples of 1500 U.S. and 500 British secondary students on the topic "What have I learned about Adolf Hitler?" were partitioned into theme-related assertions and analyzed. An experimental group of 150 9th- and 11th-grade male students who had studied the Holocaust also contributed papers…

Development of Items for a Pedagogical Content Knowledge Test Based on Empirical Analysis of Pupils' Errors

ERIC Educational Resources Information Center

Juttner, Melanie; Neuhaus, Birgit J.

2012-01-01

In view of the lack of instruments for measuring biology teachers' pedagogical content knowledge (PCK), this article reports on a study about the development of PCK items for measuring teachers' knowledge of pupils' errors and ways for dealing with them. This study investigated 9th and 10th grade German pupils' (n = 461) drawings in an achievement…

Effect of therapeutic exercises on pregnancy-related low back pain and pelvic girdle pain: Secondary analysis of a randomized controlled trial.

PubMed

Sklempe Kokic, Iva; Ivanisevic, Marina; Uremovic, Melita; Kokic, Tomislav; Pisot, Rado; Simunic, Bostjan

2017-03-06

To investigate the effect of a supervised, structured exercise programme on the occurrence and severity of pregnancy-related lumbopelvic pain. Randomized controlled trial. A total of 45 pregnant women were randomly assigned to 2 groups: an experimental group (n = 20; mean age 32.8 (standard deviation (SD) 3.6) years) and a control group (n = 22; mean age 32.2 years (SD 4.9)). Exercise intervention for the experimental group consisted of aerobic and resistance exercises performed bi-weekly from the date of inclusion into the study until the end of pregnancy, together with at least 30 min of brisk daily walks. A numeric rating scale, Roland-Morris Disability Questionnaire (RMDQ), and Pelvic Girdle Questionnaire (PGQ) were used to measure outcomes. The control group received only standard antenatal care. There were significant differences between the 2 groups on the numeric rating scale, PGQ and RMDQ scores in the 36th week of pregnancy (p = 0.017; p = 0.005; p < 0.001, respectively) in favour of the experimental group. The exercise programme had a beneficial effect on the severity of lumbopelvic pain in pregnancy, reducing the intensity of pain and the level of disability experienced as a result.

Mentoring as a Mediator or Moderator of the Association between Racial Discrimination and Coping Efficacy in Urban, Low-Income Latina/o Youth.

PubMed

Sánchez, Bernadette; Mroczkowski, Alison L; Liao, Lynn C; Cooper, Adina C; Rivera, Claudio; DuBois, David L

2017-03-01

The aim of this study was to examine the associations among mentoring relationship quality (i.e., relational and instrumental quality), racial discrimination and coping efficacy with racial discrimination. Three social support models were tested, including the stress buffering, support mobilization, and support deterioration models. Participants were 257 urban, low-income Latina/o high school students, who completed surveys in both 9th and 10th grades. While controlling for gender and coping efficacy with discrimination in 9th grade, results supported the social support deterioration model. Specifically, there was a significant indirect effect of racial discrimination in 9th grade on coping efficacy in 10th grade through instrumental mentoring quality. As racial discrimination increased, mentoring quality decreased and then coping efficacy decreased. We also found that more racial discrimination in 9th grade was significantly associated with lower coping efficacy in 10th grade, and higher instrumental mentoring quality in 9th grade was significantly associated with higher coping efficacy in 10th grade, while controlling for gender and coping efficacy in 9th grade. Implications and recommendations for future research are discussed. © Society for Community Research and Action 2017.

Epidemic history of hepatitis C virus infection in two remote communities in Nigeria, West Africa.

PubMed

Forbi, Joseph C; Purdy, Michael A; Campo, David S; Vaughan, Gilberto; Dimitrova, Zoya E; Ganova-Raeva, Lilia M; Xia, Guo-Liang; Khudyakov, Yury E

2012-07-01

We investigated the molecular epidemiology and population dynamics of HCV infection among indigenes of two semi-isolated communities in North-Central Nigeria. Despite remoteness and isolation, ~15% of the population had serological or molecular markers of hepatitis C virus (HCV) infection. Phylogenetic analysis of the NS5b sequences obtained from 60 HCV-infected residents showed that HCV variants belonged to genotype 1 (n=51; 85%) and genotype 2 (n=9; 15%). All sequences were unique and intermixed in the phylogenetic tree with HCV sequences from people infected from other West African countries. The high-throughput 454 pyrosequencing of the HCV hypervariable region 1 and an empirical threshold error correction algorithm were used to evaluate intra-host heterogeneity of HCV strains of genotype 1 (n=43) and genotype 2 (n=6) from residents of the communities. Analysis revealed a rare detectable intermixing of HCV intra-host variants among residents. Identification of genetically close HCV variants among all known groups of relatives suggests a common intra-familial HCV transmission in the communities. Applying Bayesian coalescent analysis to the NS5b sequences, the most recent common ancestors for genotype 1 and 2 variants were estimated to have existed 675 and 286 years ago, respectively. Bayesian skyline plots suggest that HCV lineages of both genotypes identified in the Nigerian communities experienced epidemic growth for 200-300 years until the mid-20th century. The data suggest a massive introduction of numerous HCV variants to the communities during the 20th century in the background of a dynamic evolutionary history of the hepatitis C epidemic in Nigeria over the past three centuries.

Characterization of a 12-pdr wrought-iron cannonball from the Akko 1 shipwreck

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cvikel, D.; Ashkenazi, D., E-mail: dana@eng.tau.ac.il; Stern, A.

2013-09-15

The Akko 1 shipwreck, discovered in Akko harbor, Israel, is the remains of an eastern Mediterranean brig built at the beginning of the 19th century. Among other finds, eleven cannonballs were found in the shipwreck and three of them were retrieved. Two of the cannonballs, the 9- and 24-pdrs, have been studied previously. The present study of the 12-pdr cannonball included γ-rays radiographic testing, XRF analysis, density measurements, optical microscopy and SEM-EDS observation, OES analysis and microhardness tests. The investigation included characterization of the composition, microstructure and slag analysis. The results revealed a quite homogenous microstructure of α-ferrite phase, withmore » glassy, wüstite and fayalite slags, as typical for a wrought-iron—annealed product, a more complicated and an earlier technology, compared to the 9- and 24-pdr that were made of cast-iron. Ferritic cannonballs are extremely rare, especially in the 19th century, when cannonballs were manufactured of cast iron by the sand casting process. The different manufacturing methods may indicate a different place of fabrication, and an apparently earlier production date for the 12-pdr, which might have even been used as ballast. - Highlights: • Three cannonballs were retrieved from the 19th century Akko 1 shipwreck. • The 12-pdr differs from the 9- and 24-pdr cannonballs previously studied. • The 12-pdr was made of high quality annealed wrought-iron, not of cast-iron. • The technology used indicates a date earlier than the middle of the 19th century. • Perhaps the 12-pdr belonged to another navy than the other two or used as ballast.« less

Predicting adolescent problematic online game use from teacher autonomy support, basic psychological needs satisfaction, and school engagement: a 2-year longitudinal study.

PubMed

Yu, Chengfu; Li, Xian; Zhang, Wei

2015-04-01

Problematic online game use (POGU) has become a serious global public health concern among adolescents. However, its influencing factors and mediating mechanisms remain largely unknown. This study provides the first longitudinal design to test stage-environment fit theory empirically in POGU. A total of 356 Chinese students reported on teacher autonomy support, basic psychological needs satisfaction, school engagement, and POGU in the autumn of their 7th-9th grade years. Path analyses supported the proposed pathway: 7th grade teacher autonomy support increased 8th grade basic psychological needs satisfaction, which in turn increased 9th grade school engagement, which ultimately decreased 9th grade POGU. Furthermore, 7th grade teacher autonomy support directly increased 9th grade school engagement, which in turn decreased 9th grade POGU. These findings suggest that teacher autonomy support is an important protective predictor of adolescent POGU, and basic psychological needs satisfaction and school engagement are the primary mediators in this association.

Locally advanced rectal cancer: post-chemoradiotherapy ADC histogram analysis for predicting a complete response.

PubMed

Cho, Seung Hyun; Kim, Gab Chul; Jang, Yun-Jin; Ryeom, Hunkyu; Kim, Hye Jung; Shin, Kyung-Min; Park, Jun Seok; Choi, Gyu-Seog; Kim, See Hyung

2015-09-01

The value of diffusion-weighted imaging (DWI) for reliable differentiation between pathologic complete response (pCR) and residual tumor is still unclear. Recently, a few studies reported that histogram analysis can be helpful to monitor the therapeutic response in various cancer research. To investigate whether post-chemoradiotherapy (CRT) apparent diffusion coefficient (ADC) histogram analysis can be helpful to predict a pCR in locally advanced rectal cancer (LARC). Fifty patients who underwent preoperative CRT followed by surgery were enrolled in this retrospective study, non-pCR (n = 41) and pCR (n = 9), respectively. ADC histogram analysis encompassing the whole tumor was performed on two post-CRT ADC600 and ADC1000 (b factors 0, 600 vs. 0, 1000 s/mm(2)) maps. Mean, minimum, maximum, SD, mode, 10th, 25th, 50th, 75th, 90th percentile ADCs, skewness, and kurtosis were derived. Diagnostic performance for predicting pCR was evaluated and compared. On both maps, 10th and 25th ADCs showed better diagnostic performance than that using mean ADC. Tenth percentile ADCs revealed the best diagnostic performance on both ADC600 (AZ 0.841, sensitivity 100%, specificity 70.7%) and ADC1000 (AZ 0.821, sensitivity 77.8%, specificity 87.8%) maps. In comparison between 10th percentile and mean ADC, the specificity was significantly improved on both ADC600 (70.7% vs. 53.7%; P = 0.031) and ADC1000 (87.8% vs. 73.2%; P = 0.039) maps. Post-CRT ADC histogram analysis is helpful for predicting pCR in LARC, especially, in improving the specificity, compared with mean ADC. © The Foundation Acta Radiologica 2014.

An Introduction to Computational Physics

NASA Astrophysics Data System (ADS)

Pang, Tao

2010-07-01

Preface to first edition; Preface; Acknowledgements; 1. Introduction; 2. Approximation of a function; 3. Numerical calculus; 4. Ordinary differential equations; 5. Numerical methods for matrices; 6. Spectral analysis; 7. Partial differential equations; 8. Molecular dynamics simulations; 9. Modeling continuous systems; 10. Monte Carlo simulations; 11. Genetic algorithm and programming; 12. Numerical renormalization; References; Index.

Numerical analyses for thinned fiber Bragg grating under uneven surrounding refractive index environment

NASA Astrophysics Data System (ADS)

Luo, Bin-bin; Zhao, Ming-fu; Zhou, Xiao-jun; Huang, De-yi; Wang, Shao-fei; Cao, Xue-mei

2011-12-01

Based on the fiber waveguide models, a modified transfer matrix method was utilized to calculate the reflection spectrum of the thinned fiber Bragg grating (ThFBG) under the uneven surrounding refractive index (SRI) environment. Tow SRI ranges, including the high SRI region (from 1.42 to the fiber cladding index) and the low ones (from 1.33 to about 1.36), were considered. Numerical results showed that the responsive characteristics of the reflectance spectrum of the ThFBG were closely related to the properties of the SRI distribution, first, the original reflection spectrum of the ThFBG would split into many tinny resonant peaks and the reflectance spectrums are asymmetric since the uneven SRI distributions, second, the number of the resonant peaks, the decline of the amplitude, and the degree of the asymmetric of the reflectance spectrums would increase as the increase in the SRI gradient and the D-value of the SRI between the tow ends of the ThFBG. The same numerical approach could be used to analyze the responsive characteristics of the ThFBG under the uneven medium environment where the SRI distribution was any other functions.

Psychological stress as a risk factor for postoperative keloid recurrence.

PubMed

Furtado, Fabianne; Hochman, Bernardo; Farber, Paulo Luiz; Muller, Marisa Campio; Hayashi, Lilian Fukusima; Ferreira, Lydia Masako

2012-04-01

To investigate psychological stress on the prognosis of the postoperative recurrence of keloids. Patients with keloids (n=25), candidates for surgical resection and postoperative radiotherapy, had their psychological stress evaluated on the day before the surgical procedure. The parameters evaluated were pain and itching (Visual Numerical Scale), quality of life (Questionnaire QualiFibro/Cirurgia Plástica-UNIFESP), perceived stress (Perceived Stress Scale), depression and anxiety (Hospital Depression and Anxiety Scale), salivary cortisol and minimum and maximum galvanic skin responses (GSR) at rest and under stress (i.e., while the questionnaires were being filled out). Patients were evaluated during the 3rd, 6th, 9th and 12th months of postoperative care. During each return visit, two experts classified the lesions as non-recurrent and recurrent. The recurrence group presented the greatest values in GSR during a stressful situation. The chance of recurrence increased by 34% at each increase of 1000 arbitrary units in maximum GSR during stress. Psychological stress influenced the recurrence of keloids. Copyright © 2012 Elsevier Inc. All rights reserved.

A longitudinal analysis of adolescent smoking: using smoking status to differentiate the influence of body weight measures.

PubMed

Hong, Traci; Johnson, Carolyn

2013-05-01

Previous research has reported mixed results on the association between body weight measures (ie, perception of weight and weight loss goal) and cigarette smoking prevalence-and how these associations vary by sex and race. This longitudinal study assessed the relationship between these 2 body weight measures and smoking prevalence by smoking status (ie, nonsmoker, former smoker, smoker). Panel data of adolescents (N = 1592) from Louisiana schools completed survey interviews in the 9th grade and again in the 12th grade. Three separate ordinary least squares (OLS) regression analyses were conducted based on respondents' smoking status in the 9th grade: nonsmoker, former smoker, and smoker. The dependent variable, smoking prevalence was assessed in the 12th grade. Among nonsmokers, weight loss goal was associated with smoking in the 12th grade. Among former smokers, the association between weight loss goal and smoking varied by sex. Girls who reported the goal to lose weight smoked more than their male counterparts. In contrast, among those who did not have the goal of losing weight, boys smoked more than girls. Among adolescents who were already smokers in the 9th grade, weight loss goal was not significantly associated with smoking prevalence. Differences in the association between weight-related variables and smoking prevalence may be attributed, in part, to smoking status. School-based smoking interventions should target nonsmokers and female former smokers who desire weight loss. © 2013, American School Health Association.

Qualitative elements of early motor development that influence reaching of the erect posture. A prospective cohort study.

PubMed

Gajewska, Ewa; Sobieska, Magdalena

2015-05-01

The proposed assessment sheet aims to show in detail, which qualitative elements of motor performance are performed correctly in the 2nd month of life by children who in the 9th month reached the erect posture. Similar analysis was performed for the qualitative assessment in the 6th month. The prospective investigation of motor development involved a group of 109 children (40 girls and 69 boys). The study was based on the previously described quantity and quality assessment sheet of motor performance, validated for the 2nd and 6th month. Final investigation took place in the 9th month of life and was based on a neurological assessment. It could be shown that a completely correct assessment at the age of 2 months precludes future severe motor development disorders, especially cerebral palsy, although it does not rule out a slight delay. Prematurity and the analyzed risk factors, particularly IVH, impair the motor performance. The absence of axial symmetry, the shoulders protraction and improper position of the pelvis are the most important alarming features at the 2nd month. Distal elements observed in the prone position at the 6th month show a good prognosis for the motor performance in the 9th month. Any abnormalities, mainly related to the body axis and symmetry observed at 2 months of age should encourage one to put a child under observation. Copyright © 2015 Elsevier Inc. All rights reserved.

Impact of Body Habitus on Phenytoin Levels Following Fosphenytoin Loading Dose in Pediatric Patients.

PubMed

Messinger, Mindl M; Moffett, Brady S; Wilfong, Angus

2015-12-01

Obesity has been shown to affect the disposition of water-soluble medications in pediatric patients. There are no published data describing serum phenytoin concentrations in obese pediatric patients. A retrospective descriptive study was designed that included patients from 2011 to 2013 between 2 and 19 years of age who received a dose of fosphenytoin with a subsequent serum phenytoin concentration, drawn 2-4 hours postloading dose. Body mass index (BMI) was calculated and patients were categorized by BMI percentiles into underweight (<5th percentile), normal weight (5th-84th percentile), overweight (85th-94th percentile), and obese (≥95th percentile). Descriptive statistical analysis and comparisons between groups occurred to determine differences in serum phenytoin concentrations. Multivariable linear regression analysis was performed to determine the effect of body habitus on serum phenytoin concentrations. One hundred ten patients met study criteria (male 51.8%, mean age: 8.3 ± 4.9 years). Patients were normal weight (47.3%), underweight (20.9%), overweight (14.6%), and obese (17.3%). No significant differences were identified between groups in regard to patient demographics, with the exception of weight (P < 0.05). The mean fosphenytoin dose was 23.4 ± 5.7 mg Phenytoin Equivalents (PE)/kg and the serum phenytoin concentration was 22.4 ± 6.8 mg/L measured at 2.9 ± 0.6 hours after dose, and this did not vary significantly across groups (P > 0.05). Multivariable linear regression identified body habitus as a nonsignificant predictor of serum phenytoin concentrations (P > 0.05). Patients of higher BMI did not require further antiepileptic therapy as compared with patients with lower BMI (P > 0.05). Contrary to the adult population, loading dose adjustments do not seem to be required in pediatric patients. Obesity does not affect serum phenytoin concentrations in pediatric patients after intravenous bolus fosphenytoin administration.

Basic numerical capacities and prevalence of developmental dyscalculia: the Havana Survey.

PubMed

Reigosa-Crespo, Vivian; Valdés-Sosa, Mitchell; Butterworth, Brian; Estévez, Nancy; Rodríguez, Marisol; Santos, Elsa; Torres, Paul; Suárez, Ramón; Lage, Agustín

2012-01-01

The association of enumeration and number comparison capacities with arithmetical competence was examined in a large sample of children from 2nd to 9th grades. It was found that efficiency on numerical capacities predicted separately more than 25% of the variance in the individual differences on a timed arithmetical test, and this occurred for both younger and older learners. These capacities were also significant predictors of individual variations in an untimed curriculum-based math achievement test and on the teacher scores of math performance over developmental time. Based on these findings, these numerical capacities were used for estimating the prevalence and gender ratio of basic numerical deficits and developmental dyscalculia (DD) over the grade range defined above (N = 11,652 children). The extent to which DD affects the population with poor ability on calculation was also examined. For this purpose, the prevalence and gender ratio of arithmetical dysfluency (AD) were estimated in the same cohort. The estimated prevalence of DD was 3.4%, and the male:female ratio was 4:1. However, the prevalence of AD was almost 3 times as high (9.35%), and no gender differences were found (male:female ratio = 1.07:1). Basic numerical deficits affect 4.54% of school-age population and affect more boys than girls (2.4:1). The differences between the corresponding estimates were highly significant (α < .01). Based on these contrastive findings, it is concluded that DD, defined as a defective sense of numerosity, could be a distinctive disorder that affects only a portion of children with AD.

Data-Driven Modeling of Solar Corona by a New 3d Path-Conservative Osher-Solomon MHD Odel

NASA Astrophysics Data System (ADS)

Feng, X. S.; Li, C.

2017-12-01

A second-order path-conservative scheme with Godunov-type finite volume method (FVM) has been implemented to advance the equations of single-fluid solar wind plasma magnetohydrodynamics (MHD) in time. This code operates on the six-component composite grid system in 3D spherical coordinates with hexahedral cells of quadrilateral frustum type. The generalized Osher-Solomon Riemann solver is employed based on a numerical integration of the path-dependentdissipation matrix. For simplicity, the straight line segment path is used and the path-integral is evaluated in a fully numerical way by high-order numerical Gauss-Legendre quadrature. Besides its closest similarity to Godunov, the resulting scheme retains the attractive features of the original solver: it is nonlinear, free of entropy-fix, differentiable and complete in that each characteristic field results in a different numerical viscosity, due to the full use of the MHD eigenstructure. By using a minmod limiter for spatial oscillation control, the pathconservative scheme is realized for the generalized Lagrange multiplier (GLM) and the extended generalized Lagrange multiplier (EGLM) formulation of solar wind MHD systems. This new model of second-order in space and time is written in FORTRAN language with Message Passing Interface (MPI) parallelization, and validated in modeling time-dependent large-scale structure of solar corona, driven continuously by the Global Oscillation Network Group (GONG) data. To demonstrate the suitability of our code for the simulation of solar wind, we present selected results from October 9th, 2009 to December 29th, 2009 , & Year 2008 to show its capability of producing structured solar wind in agreement with the observations.

Higher-order triangular spectral element method with optimized cubature points for seismic wavefield modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Youshan, E-mail: ysliu@mail.iggcas.ac.cn; Teng, Jiwen, E-mail: jwteng@mail.iggcas.ac.cn; Xu, Tao, E-mail: xutao@mail.iggcas.ac.cn

2017-05-01

The mass-lumped method avoids the cost of inverting the mass matrix and simultaneously maintains spatial accuracy by adopting additional interior integration points, known as cubature points. To date, such points are only known analytically in tensor domains, such as quadrilateral or hexahedral elements. Thus, the diagonal-mass-matrix spectral element method (SEM) in non-tensor domains always relies on numerically computed interpolation points or quadrature points. However, only the cubature points for degrees 1 to 6 are known, which is the reason that we have developed a p-norm-based optimization algorithm to obtain higher-order cubature points. In this way, we obtain and tabulate newmore » cubature points with all positive integration weights for degrees 7 to 9. The dispersion analysis illustrates that the dispersion relation determined from the new optimized cubature points is comparable to that of the mass and stiffness matrices obtained by exact integration. Simultaneously, the Lebesgue constant for the new optimized cubature points indicates its surprisingly good interpolation properties. As a result, such points provide both good interpolation properties and integration accuracy. The Courant–Friedrichs–Lewy (CFL) numbers are tabulated for the conventional Fekete-based triangular spectral element (TSEM), the TSEM with exact integration, and the optimized cubature-based TSEM (OTSEM). A complementary study demonstrates the spectral convergence of the OTSEM. A numerical example conducted on a half-space model demonstrates that the OTSEM improves the accuracy by approximately one order of magnitude compared to the conventional Fekete-based TSEM. In particular, the accuracy of the 7th-order OTSEM is even higher than that of the 14th-order Fekete-based TSEM. Furthermore, the OTSEM produces a result that can compete in accuracy with the quadrilateral SEM (QSEM). The high accuracy of the OTSEM is also tested with a non-flat topography model. In terms of computational efficiency, the OTSEM is more efficient than the Fekete-based TSEM, although it is slightly costlier than the QSEM when a comparable numerical accuracy is required. - Highlights: • Higher-order cubature points for degrees 7 to 9 are developed. • The effects of quadrature rule on the mass and stiffness matrices has been conducted. • The cubature points have always positive integration weights. • Freeing from the inversion of a wide bandwidth mass matrix. • The accuracy of the TSEM has been improved in about one order of magnitude.« less

A case study of sea breeze circulation at Thumba Coast through observations and modelling

NASA Astrophysics Data System (ADS)

Kunhikrishnan, P. K.; Ramachandran, Radhika; Alappattu, Denny P.; Kiran Kumar, N. V. P.; Balasubrahamanyam, D.

2006-12-01

A case study of sea breeze circulation at a coastal region Thumba (8.5°N, 76.9°E) was carried out using Doppler Sodar, surface wind, temperature, humidity measurements and radiosonde ascents. The analysis of surface meteorological data showed that the onset of sea breeze on 12th April 2006 was at 0945 hrs. GPS sonde observation over sea at 1425 hrs and Radiosonde observation over land at 1730 showed a well developed sea breeze circulation over Thumba coast by afternoon hours. The vertical extent of sea breeze circulation was ~1000m over sea as well as on land. The Thermal Internal Boundary Layer (TIBL) depth associated with sea breeze circulation was about 400m at 8 km away from coast. The marine mixed layer height was ~500m about 12 km away from the coast. Numerical simulation of sea breeze was made using HRM (High Resolution Model) and compared the results with the observations.

Hypereosinophilia with abnormal T cells, trisomy 7 and elevated TARC serum level.

PubMed

Roumier, A S; Grardel, N; Laï, J L; Becqueriaux, I; Ghomari, K; de Lavareille, A; Roufosse, F; Prin, L; Capron, M

2003-07-01

The idiopathic hypereosinophilic syndrome (HES) is a rare heterogeneous disorder, characterized by persistent blood eosinophilia with possible organ involvement. We describe here the case of a 20-year-old atopic male presenting chronic hypereosinophilia and eczema since childhood. Biological findings included hypereosinophilia (9.5 x 10(9)/L), hyperlymphocytosis (10.9 x 10(9)/L), polyclonal hypergammaglobulinemia and elevated IgE serum level. Flow cytometric analysis of blood lymphoid cells showed a population of CD2+CD3-CD4+TCRab-TCRgd- lymphocytes. These cells displayed a Th0/Th2 cytokine profile, and a clonal TCR rearrangement pattern. A high serum TARC level was observed. Karyotype studies on blood stimulated culture or lymph nodes revealed a cellular hyperdiploïd clone 47, XY, +7. To our knowledge, this chromosomal aberration has never been reported in such case.

Extent of areal inundation of riverine wetlands along five river systems in the upper Hillsborough river watershed, west-central Florida

USGS Publications Warehouse

Lewelling, B.R.

2004-01-01

Riverine and palustrine wetlands are a major ecological component of river basins in west-central Florida. Healthy wetlands are dependent, in part, upon the frequency and duration of periodic flooding or inundation. This report assesses the extent, area, depth, frequency, and duration of periodic flooding and the effects of potential surface-water withdrawals on wetlands along five river systems in the upper Hillsborough River watershed: Hillsborough and New Rivers, Blackwater and Itchepackesassa Creeks, and East Canal. Results of the study were derived from step-backwater analyses performed for each of the river systems using the U.S. Army Corps of Engineers Hydrologic Engineering Center-River Analysis System (HEC-RAS) one-dimensional model. Step-backwater analyses were performed based on daily mean discharges at the 10th, 50th, 70th, 80th, 90th, 95th, 99.5th, and 99.97th percentiles for selected periods. The step-backwater analyses computed extent of inundation, area of inundation, and hydraulic depth. An assessment of the net reduction of areal inundation for each of the selected percentile discharges was computed if 10 percent of the total river flow were diverted for potential withdrawals. The extent of areal inundation at a cross section is controlled by discharge volume, topography, and the degree to which the channel is incised. Areal inundation can occur in reaches characterized by low topographic relief in the upper Hillsborough watershed during most, if not all, selected discharge percentiles. Most river systems in the watershed, however, have well defined and moderately incised channels that generally confine discharges within the banks at the 90th percentile. The greatest increase in inundated area along the five river systems generally occurred between the 95th to 99.5th percentile discharges. The decrease in inundated area that would result from a potential 10-percent discharge withdrawal at the five river systems ranged as follows: Hillsborough River, 7 to 940 acres (2.0 to 6.0 percent); and New River, 0.2 to 58.9 acres (0 to 11.9 percent); Blackwater Creek, 3.3 to 148 acres (2.2 to 9.4 percent); Itchepackesassa Creek, 1.0 to 104 acres (0.9 to 10.8 percent); and East Canal 0.7 to 34.6 acres (0.5 to 7.6 percent).

{Lambda}K*{Lambda}(1116) photoproduction and nucleon resonances

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Sang-Ho; Kim, Hyun-Chul; Nam, Seung-il

2011-10-21

In this presentation, we report our recent studies on the {Lambda}K*{Lambda}(1116) photoproduction off the proton target, using the tree-level Born approximation, via the effective Lagrangian approach. In addition, we include the nine (three- or four-star confirmed) nucleon resonances below the threshold {radical}(s{sub th}){approx_equal}2008 MeV, to interpret the discrepancy between the experiment and previous theoretical studies, in the vicinity of the threshold region. From the numerical studies, we observe that the S{sub 11}(1535) and S11(1650) play an important role for the cross-section enhancement near the {radical}(s{sub th}). It also turns out that, in order to reproduce the data, we have themore » vector coupling constants gK*S{sub 11}(1535){Lambda} = (7.0{approx}9.0) and gK*S{sub 11}(1650){Lambda} (5.0{approx}6.0).« less

Light Helicopter Family Trade-Off Analysis. Volume 4. Appendix N

DTIC Science & Technology

1985-05-15

Figur«! N -V1I-9 through N -VII-U ahow th« futl flow CMp«rlsoas chac comt|>oad r.o th« powar r«qutr«««nt* thown by flguraa (J-VII-l through M-VII-4...HELICOPTER. FAMILY TRADE-OFF ANALYSIS APPENDIX N VOLUME IV ACN: 69396 • Copy l_Q] of 130 c:optea. 15 Nay 198S ~ .. 8 06 .0&1 OTIC ELECTE AU613...TITLE (- ..... do) I. TYPf ’!! ~POitT a PI!I’IOD COVI:IU!O LIGHT HELICOPTER FAMILY TRADE-OFF ANALYSIS, Fina t y Report, APPENDIX N , VOLUME IV of XI

An Analysis of the Implementation of the Standard Accounting, Budgeting and Reporting System (SABRS) in the 4th Marine Division.

DTIC Science & Technology

1980-12-01

REPOR DOCUMENTATION PAGE - 33703 COMPLZT!Nc PORN I.RPRNUM69M L. GOV"T ACCESSION NO. I. RECIPIEN4TS CATALOG NUNS9R a. TITLE (mds ume An Anaiysi s of th...wagging the dog ." The development schedule for SABRS envisions the three phases of concept formulation, Automated Data Systems (ADS) development and

Radiographic Prevalence of Femoroacetabular Impingement in a Young Population with Hip Complaints Is High

DTIC Science & Technology

2010-01-27

Sciatica 724.3 Abnormality of gait 781.2 ICD-9 = International Classification of Diseases, 9th Revision; NOS = not otherwise specified. Volume 468, Number...the patients were not considered in our analysis, specifically diagnoses such as sacroiliitis or sciatica , in which clinical symptoms may not be

Direct vertebral body derotation, thoracoplasty, or both: which is better with respect to inclinometer and scoliosis research society-22 scores?

PubMed

Samdani, Amer F; Hwang, Steven W; Miyanji, Firoz; Lonner, Baron; Marks, Michelle C; Sponseller, Paul D; Newton, Peter O; Cahill, Patrick J; Shufflebarger, Harry L; Betz, Randal R

2012-06-15

Prospective, longitudinal cohort (nonrandomized). To compare thoracoplasty (Th), direct vertebral body derotation (DVBD), and Th and DVBD with respect to correction of the rib prominence and Scoliosis Research Society (SRS) self-image scores in patients undergoing surgery for adolescent idiopathic scoliosis (AIS). Rib prominence correction is one of the main goals of AIS surgery. Th and DVBD are powerful tools for correction of the rib prominence; however, a paucity of literature exists comparing Th, DVBD, and Th and DVBD. A prospective longitudinal database was queried to identify patients with AIS who underwent a posterior spinal fusion with pedicle screws and 2 years of follow-up. A total of 326 patients were identified and divided into 3 groups: (1) Th alone (N = 47), (2) DVBD alone (N = 196), and (3) both Th and DVBD (N = 83). Patients were subdivided into categories on the basis of their preoperative inclinometer reading: (1) ≤9° (mild), (2) 10 to 15° (moderate), and (3) ≥ 16° (severe). Pre- and postoperative inclinometer readings and SRS self-image scores were compared using analysis of variance. Overall, the groups were similar preoperatively except for the DVBD group having higher percentage of thoracic flexibility. The preoperative rib prominence values were Th = 13.2, DVBD = 14.0, and Th and DVBD = 12.9 (P = 0.27). Taken collectively, the postoperative 2-year inclinometer readings were similar for all 3 groups (Th = 5.2, DVBD = 7.0, Th and DVBD = 5.6; P = 0.66). However, the SRS-22 self-image scores were significantly better for patients having both Th and DVBD (Th = 3.37, DVBD = 3.44, Th and DVBD = 3.76; P < 0.01). When patients were stratified by severity of preoperative rib prominence, all patients with mild prominences achieved similar corrections, although SRS self-image scores were highest in the Th and DVBD group. In patients with larger rib prominences, the addition of Th was necessary for optimal rib prominence correction, but there was no difference in SRS-22 self-image scores. Our results suggest that Th alone, DVBD alone, or both Th and DVBD provide equivalent inclinometer results in patients with mild preoperative rib prominences (≤ 9°), but higher SRS-22 self-image scores are achieved using both Th and DVBD. For larger rib prominences, better inclinometer readings are achieved with Th, although SRS-22 self-image scores are comparable.

The effect of curriculum changes and instructional techniques on science-reasoning skills among high school students

NASA Astrophysics Data System (ADS)

Newman, Joan T.

Any change, particularly on a large scale like a sequence change in a district with 75,000 students, is difficult. However, with the advent of the new TAKS science test and the new requirements for high school graduation in the state of Texas, educators and students alike are engaged in innovative educational approaches to meet these requirements. This study investigated a different, non-traditional science sequence to investigate relationships among secondary core-science course sequencing, student science-reasoning performance, and classroom pedagogy. The methodology adopted in the study led to a deeper understanding of the successes and challenges faced by teachers in teaching conceptual physics and chemistry to 8 th and 9th grade students. The qualitative analysis suggested a difference in pedagogy employed by middle and high school science teachers and a need for secondary science teachers to enhance their content knowledge and pedagogical skills, as well as change their underlying attitudes and beliefs about the abilities of students. The study examined scores of 495 randomly chosen students following three different matriculation patterns within one large independent school district. The study indicated that students who follow a sequence with 9th grade IPC generally increase their science-reasoning skills as demonstrated on the 10th grade TAKS science test when these scores are compared with those of students who do not have 9th grade IPC in the science sequence.

A Numerical Simulator for Three-Dimensional Flows Through Vibrating Blade Rows

NASA Technical Reports Server (NTRS)

Chuang, H. Andrew; Verdon, Joseph M.

1998-01-01

The three-dimensional, multi-stage, unsteady, turbomachinery analysis, TURBO, has been extended to predict the aeroelastic and aeroacoustic response behaviors of a single blade row operating within a cylindrical annular duct. In particular, a blade vibration capability has been incorporated so that the TURBO analysis can be applied over a solution domain that deforms with a vibratory blade motion. Also, unsteady far-field conditions have been implemented to render the computational boundaries at inlet and exit transparent to outgoing unsteady disturbances. The modified TURBO analysis is applied herein to predict unsteady subsonic and transonic flows. The intent is to partially validate this nonlinear analysis for blade flutter applications, via numerical results for benchmark unsteady flows, and to demonstrate the analysis for a realistic fan rotor. For these purposes, we have considered unsteady subsonic flows through a 3D version of the 10th Standard Cascade, and unsteady transonic flows through the first stage rotor of the NASA Lewis, Rotor 67, two-stage fan.

[Phoneme analysis and phoneme discrimination of juvenile speech therapy school students].

PubMed

Franz, S; Rosanowski, F; Eysholdt, U; Hoppe, U

2011-05-01

Phoneme analysis and phoneme discrimination, important factors in acquiring spoken and written language, have been evaluated in juvenile speech therapy school students. The results have been correlated with the results of a school achievement test. The following questions were of interest: Do students in the lower verbal skill segment show pathological phoneme analysis and phoneme discrimination skills? Do the results of the school achievement test differ from the results by students visiting German "Hauptschule"? How does phoneme analysis and phoneme discrimination performance correlate to other tested parameters? 74 students of a speech therapy school ranging from 7 (th) to 9 (th) grade were examined (ages 12;10-17;04) with the Heidelberg Phoneme Discrimination Test H-LAD and the school achievement test "Prüfsystem für Schul- und Bildungsberatung PSB-R 6-13". Compared to 4 (th) graders the juvenile speech therapy school students showed worse results in the H-LAD test with good differentiation in the lower measuring range. In the PSB-R 6-13 test the examined students did worse compared to students visiting German "Hauptschule" for all grades except 9 (th) grade. Comparing H-LAD and PSB-R 6-13 shows a significant correlation for the sub-tests covering language competence and intelligence but not for the concentration tests. Pathological phoneme analysis and phoneme discrimination skills suggest elevated need for counseling, but this needs to corroborated through additional linguistic parameters and measuring non-verbal intelligence. Further trails are needed in order to clarify whether the results can lead to sophisticated therapy algorithms for educational purposes. © Georg Thieme Verlag KG Stuttgart · New York.

An Introduction to Computational Physics - 2nd Edition

NASA Astrophysics Data System (ADS)

Pang, Tao

2006-01-01

Preface to first edition; Preface; Acknowledgements; 1. Introduction; 2. Approximation of a function; 3. Numerical calculus; 4. Ordinary differential equations; 5. Numerical methods for matrices; 6. Spectral analysis; 7. Partial differential equations; 8. Molecular dynamics simulations; 9. Modeling continuous systems; 10. Monte Carlo simulations; 11. Genetic algorithm and programming; 12. Numerical renormalization; References; Index.

Numerical studies of acceleration of thorium ions by a laser pulse of ultra-relativistic intensity

NASA Astrophysics Data System (ADS)

Domanski, Jaroslaw; Badziak, Jan

2018-01-01

One of the key scientific projects of ELI-Nuclear Physics is to study the production of extremely neutron-rich nuclides by a new reaction mechanism called fission-fusion using laser-accelerated thorium (232Th) ions. This research is of crucial importance for understanding the nature of the creation of heavy elements in the Universe; however, they require Th ion beams of very high beam fluencies and intensities which are inaccessible in conventional accelerators. This contribution is a first attempt to investigate the possibility of the generation of intense Th ion beams by a fs laser pulse of ultra-relativistic intensity. The investigation was performed with the use of fully electromagnetic relativistic particle-in-cell code. A sub-μm thorium target was irradiated by a circularly polarized 20-fs laser pulse of intensity up to 1023 W/cm2, predicted to be attainable at ELI-NP. At the laser intensity 1023 W/cm2 and an optimum target thickness, the maximum energies of Th ions approach 9.3 GeV, the ion beam intensity is > 1020 W/cm2 and the total ion fluence reaches values 1019 ions/cm2. The last two values are much higher than attainable in conventional accelerators and are fairly promising for the planned ELI-NP experiment.

Pertussis Circulation Has Increased T-Cell Immunity during Childhood More than a Second Acellular Booster Vaccination in Dutch Children 9 Years of Age

PubMed Central

Schure, Rose-Minke; de Rond, Lia; Öztürk, Kemal; Hendrikx, Lotte; Sanders, Elisabeth; Berbers, Guy; Buisman, Anne-Marie

2012-01-01

Here we report the first evaluation of T-cell responses upon a second acellular pertussis booster vaccination in Dutch children at 9 years of age, 5 years after a preschool booster vaccination. Blood samples of children 9 years of age were studied longitudinally until 1 year after the second aP booster and compared with those after the first aP booster in children 4 and 6 years of age from a cross-sectional study. After stimulation with pertussis-vaccine antigens, Th1, Th2 and Th17 cytokine responses were measured and effector memory cells (CCR7-CD45RA-) were characterized by 8-colour FACS analysis. The second aP booster vaccination at pre-adolescent age in wP primed individuals did increase pertussis-specific Th1 and Th2 cytokine responses. Noticeably, almost all T-cell responses had increased with age and were already high before the booster vaccination at 9 years of age. The enhancement of T-cell immunity during the 5 year following the booster at 4 years of age is probably caused by natural boosting due to the a high circulation of pertussis. However, the incidence of pertussis is high in adolescents and adults who have only received the Dutch wP vaccine during infancy and no booster at 4 years of age. Therefore, an aP booster vaccination at adolescence or later in these populations might improve long-term immunity against pertussis and reduce the transmission to the vulnerable newborns. Trial Registration Controlled-Trials.com ISRCTN64117538 PMID:22860033

Types of injuries among Polish soldiers and civilian staff in the 7th, 8th, 9th and 10th rotation of the Afghan stabilization mission

PubMed Central

Ziemba, Radosław

2012-01-01

Summary Background The Afghan military theatre is specifically marked by guerilla operations and massive use of IEDs (improvised explosive devices) that pose new types of threats for their victims. At the same time, the relevant literature contains only a single, fragmentary analysis on injuries suffered by soldiers serving in the Afghan mission. Material/Methods This is a review of medical reports of the Polish Military Contingent deployed within Operation Enduring Freedom, from 1 January 2010 to 31 December 2011; the analysis includes all cases of combat and non-combat injuries in terms of their causes. Results In the period under analysis, 380 Polish soldiers were reported injured; 87.1% of cases were combat and 12.9% non-combat injuries. The structure of injuries caused as a result of IED explosions was dominated by multiple limb injuries, associated most frequently with severe body cavities/spine injuries. In the case of other incidents, both combat and non-combat, the predominant consequences were single and, most commonly, less severe injuries. The average number of injuries suffered from IED attacks (3.37) was significantly higher than the number of injuries from other attacks (1.16), and higher than the number of non-combat injuries (1.43). Conclusions IED attacks pose a serious medical problem, considering their high number and the severity of injuries they cause. PMID:22367143

A Chemistry Course for High Ability 8th, 9th, and 10th Graders.

ERIC Educational Resources Information Center

Kilker, Richard, Jr.

1985-01-01

Describes a chemistry course designed, in cooperation with local public school districts, to intellectually challenge a group of 8th, 9th, and 10th grade students. Organic chemistry and biochemistry are integrated into the course (titled Chemistry and Everyday Life) to emphasize practical applications of chemistry. The course syllabus is included.…

Percentile reference values for anthropometric body composition indices in European children from the IDEFICS study.

PubMed

Nagy, P; Kovacs, E; Moreno, L A; Veidebaum, T; Tornaritis, M; Kourides, Y; Siani, A; Lauria, F; Sioen, I; Claessens, M; Mårild, S; Lissner, L; Bammann, K; Intemann, T; Buck, C; Pigeot, I; Ahrens, W; Molnár, D

2014-09-01

To characterise the nutritional status in children with obesity or wasting conditions, European anthropometric reference values for body composition measures beyond the body mass index (BMI) are needed. Differentiated assessment of body composition in children has long been hampered by the lack of appropriate references. The aim of our study is to provide percentiles for body composition indices in normal weight European children, based on the IDEFICS cohort (Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and infantS). Overall 18,745 2.0-10.9-year-old children from eight countries participated in the study. Children classified as overweight/obese or underweight according to IOTF (N=5915) were excluded from the analysis. Anthropometric measurements (BMI (N=12 830); triceps, subscapular, fat mass and fat mass index (N=11,845-11,901); biceps, suprailiac skinfolds, sum of skinfolds calculated from skinfold thicknesses (N=8129-8205), neck circumference (N=12,241); waist circumference and waist-to-height ratio (N=12,381)) were analysed stratified by sex and smoothed 1st, 3rd, 10th, 25th, 50th, 75th, 90th, 97th and 99th percentile curves were calculated using GAMLSS. Percentile values of the most important anthropometric measures related to the degree of adiposity are depicted for European girls and boys. Age- and sex-specific differences were investigated for all measures. As an example, the 50th and 99th percentile values of waist circumference ranged from 50.7-59.2 cm and from 51.3-58.7 cm in 4.5- to <5.0-year-old girls and boys, respectively, to 60.6-74.5 cm in girls and to 59.9-76.7 cm in boys at the age of 10.5-10.9 years. The presented percentile curves may aid a differentiated assessment of total and abdominal adiposity in European children.

Birth weight by gestational age in twin pregnancies: analysis of 661 pairs.

PubMed

Hsieh, T T; Chen, C J; Hsu, J J

1992-02-01

The mortality of twin infants is four to five times higher than that of singletons, and one-half to two-thirds of all twins weigh < 2,500 g at birth. The appropriate interpretation of fetal growth throughout pregnancy is dependent upon the availability of adequate standards. We reviewed 661 pairs of live twin infants born at Chang Gung Memorial Hospital from 1979 to 1990. The frequency of twin births was 1.17% (1:86), and the ratio of males to females was 1.03. The frequency of preterm births (< 37 weeks) was 36.9%, the frequency of low birth weight (< 2,500 g) was 47.9% and very low birth weight (< 1,500 g) was 6.7%. A fetus grows most rapidly from the 32nd to the 35th week of gestation (200 g per week). The growth was 145 g per week from the 28th to the 32nd week and from the 35th to the 38th week of gestation. After the 38th week, the mean birth weight increased by only 35 g per week. Compared with a singleton birth, the mean birth weight of twins was about 100 g lighter during the 28th to the 32nd week, then the difference increased gradually to about 500 g at term.

A Three-Dimensional Linearized Unsteady Euler Analysis for Turbomachinery Blade Rows

NASA Technical Reports Server (NTRS)

Montgomery, Matthew D.; Verdon, Joseph M.

1997-01-01

A three-dimensional, linearized, Euler analysis is being developed to provide an efficient unsteady aerodynamic analysis that can be used to predict the aeroelastic and aeroacoustic responses of axial-flow turbo-machinery blading.The field equations and boundary conditions needed to describe nonlinear and linearized inviscid unsteady flows through a blade row operating within a cylindrical annular duct are presented. A numerical model for linearized inviscid unsteady flows, which couples a near-field, implicit, wave-split, finite volume analysis to a far-field eigenanalysis, is also described. The linearized aerodynamic and numerical models have been implemented into a three-dimensional linearized unsteady flow code, called LINFLUX. This code has been applied to selected, benchmark, unsteady, subsonic flows to establish its accuracy and to demonstrate its current capabilities. The unsteady flows considered, have been chosen to allow convenient comparisons between the LINFLUX results and those of well-known, two-dimensional, unsteady flow codes. Detailed numerical results for a helical fan and a three-dimensional version of the 10th Standard Cascade indicate that important progress has been made towards the development of a reliable and useful, three-dimensional, prediction capability that can be used in aeroelastic and aeroacoustic design studies.

Relationship between tumor biomarkers and efficacy in TH3RESA, a phase III study of trastuzumab emtansine (T-DM1) vs. treatment of physician's choice in previously treated HER2-positive advanced breast cancer.

PubMed

Kim, Sung-Bae; Wildiers, Hans; Krop, Ian E; Smitt, Melanie; Yu, Ron; Lysbet de Haas, Sanne; Gonzalez-Martin, Antonio

2016-11-15

In the phase III TH3RESA study (NCT01419197), 602 patients with HER2-positive advanced breast cancer who received prior taxane therapy and ≥2 HER2-directed regimens, including trastuzumab and lapatinib (advanced setting), were randomized to trastuzumab emtansine (T-DM1) or treatment of physician's choice (TPC). A statistically significant progression-free survival (PFS) benefit favoring T-DM1 was demonstrated. Here, we examine the relationship between HER2-related biomarkers and PFS in an exploratory analysis. Biomarkers assessed included HER2 (n = 505) and HER3 (n = 505) mRNA expression, PIK3CA mutation status (n = 410) and PTEN protein expression (n = 358). For biomarkers with continuous data (HER2, HER3, PTEN), subgroups were defined using median values (>median and ≤median). For all biomarker subgroups, median PFS was longer with T-DM1 vs. TPC. The PFS benefit favoring T-DM1 vs. TPC was numerically greater in the HER2 mRNA >median subgroup (7.2 vs. 3.4 months; unstratified hazard ratio [HR], 0.40; 95% CI, 0.28-0.59; p < 0.0001) vs. ≤median subgroup (5.5 vs. 3.9 months; HR, 0.68; 95% CI, 0.49-0.92; p = 0.0131). The PFS benefit with T-DM1 was similar among HER3, PIK3CA and PTEN subgroups. Consistent with other reports, benefit was seen with T-DM1 regardless of PIK3CA mutation status. In a multivariate analysis including an interaction term (treatment group by log2-transformed HER2 mRNA), patients with higher HER2 mRNA levels benefited more from receiving T-DM1 (HR, 0.84; 95% CI, 0.75-0.94; interaction p value = 0.0027). In summary, T-DM1 prolonged median PFS in all biomarker subgroups analyzed, including activating PIK3CA mutations, with numerically greater benefit in patients with tumors expressing HER2 mRNA >median vs. ≤median. © 2016 UICC.

The a(3) Scheme--A Fourth-Order Space-Time Flux-Conserving and Neutrally Stable CESE Solver

NASA Technical Reports Server (NTRS)

Chang, Sin-Chung

2008-01-01

The CESE development is driven by a belief that a solver should (i) enforce conservation laws in both space and time, and (ii) be built from a non-dissipative (i.e., neutrally stable) core scheme so that the numerical dissipation can be controlled effectively. To initiate a systematic CESE development of high order schemes, in this paper we provide a thorough discussion on the structure, consistency, stability, phase error, and accuracy of a new 4th-order space-time flux-conserving and neutrally stable CESE solver of an 1D scalar advection equation. The space-time stencil of this two-level explicit scheme is formed by one point at the upper time level and three points at the lower time level. Because it is associated with three independent mesh variables (the numerical analogues of the dependent variable and its 1st-order and 2ndorder spatial derivatives, respectively) and three equations per mesh point, the new scheme is referred to as the a(3) scheme. Through the von Neumann analysis, it is shown that the a(3) scheme is stable if and only if the Courant number is less than 0.5. Moreover, it is established numerically that the a(3) scheme is 4th-order accurate.

Mid-infrared-to-mid-ultraviolet supercontinuum enhanced by third-to-fifteenth odd harmonics.

PubMed

Mitrofanov, A V; Voronin, A A; Mitryukovskiy, S I; Sidorov-Biryukov, D A; Pugžlys, A; Andriukaitis, G; Flöry, T; Stepanov, E A; Fedotov, A B; Baltuška, A; Zheltikov, A M

2015-05-01

A high-energy supercontinuum spanning 4.7 octaves, from 250 to 6500 nm, is generated using a 0.3-TW, 3.9-μm output of a mid-infrared optical parametric chirped-pulse amplifier as a driver inducing a laser filament in the air. The high-frequency wing of the supercontinuum spectrum is enhanced by odd-order optical harmonics of the mid-infrared driver. Optical harmonics up to the 15th order are observed in supercontinuum spectra as overlapping, yet well-resolved peaks broadened, as verified by numerical modeling, due to spatially nonuniform ionization-induced blue shift.

Mathematical Creativity and Mathematical Aptitude: A Cross-Lagged Panel Analysis

ERIC Educational Resources Information Center

Tyagi, Tarun Kumar

2016-01-01

Cross-lagged panel correlation (CLPC) analysis has been used to identify causal relationships between mathematical creativity and mathematical aptitude. For this study, 480 8th standard students were selected through a random cluster technique from 9 intermediate and high schools of Varanasi, India. Mathematical creativity and mathematical…

Changing Intergroup Relations with Mainland Chinese: An Analysis of Changes in Hong Kong Movies as a Popular Cultural Discourse

ERIC Educational Resources Information Center

Fong, Emily Tsz Yan

2010-01-01

Hong Kong popular culture played an important role in the construction and consolidation of Hong Kong identity long before the handover to China. In the past few years leading up to the 10th anniversary of the handover, both Hong Kong and China have undergone numerous changes which seem to be changing their relations. Whilst Hong Kong people had…

Historical horoscopes as a source of the history of science. (German Title: Historische Horoskope als Quelle der Wissenschaftsgeschichte)

NASA Astrophysics Data System (ADS)

Oestmann, Günther

The paper deals with the analysis and interpretation of historic horoscopes. The astrological activities of Count Heinrich Rantzau (1526-1598), Danish Governor of Schleswig-Holstein, who was one of the leading representatives of humanistic learning and culture in the 16th century, have been taken as an example. He corresponded with numerous scholars and was a friend of Tycho Brahe.

[Equity in health according to reports by the Brazilian National Health Conferences since enactment of the 1988 Federal Constitution].

PubMed

Pinheiro, Marcelo Cardoso; Westphal, Márcia Faria; Akerman, Marco

2005-01-01

Based on a literature review and taking into account a concept of equity and its application to the field of public health, this article discusses the meaning ascribed to the term "equity" and its variations in the reports by the 9th, 10th, and 11th National Health Conferences in Brazil. Qualitative methods and content analysis were used to evaluate the approach to equity in two products the Conferences intended to formulate: analysis and presentation of the country's health profile and guidelines for public health policies. Little progress in understanding the issue of equity in health was observed; the predominant discourse was vague or excessively broad. The proposals were generic and nonspecific, failing to define the target problems and social groups.

Velocity dispersions in galaxies: 1: The SO galaxy NGC 7332

NASA Technical Reports Server (NTRS)

Morton, D. C.; Chevalier, R. A.

1971-01-01

A Coude spectrum of the SO galaxy NGC 7332 with 0.9 A resolution from 4186 to 4364 A was obtained with the SEC vidicon television camera and the Hale telescope. Comparisons with spectra of G and K giant stars, numerically broadened for various Maxwellian velocity distributions, give a dispersion velocity in the line of sight of 160 + or - 20 km/sec with the best fit at G8III. The dispersion appears to be constant within + or - 35 km/sec out to 1.4 kpc (H = 100 km/sec/mpc). After correction for projection, the rotation curve has a slope of 0.16 km/sec/pc at the center and a velocity of 130 km/sec at 1.4 kpc where it is still increasing. For an estimated effective radius of 3.5 kpc enclosing half the light, the virial theorem gives a mass of 1.4 x 10 to the 11th power solar masses if the mass-to-light ratio is constant throughout the galaxy. The photographic luminosity is 8.3 x 10 to the 9th power solar luminosities so that the M/L ratio is 17.

External and internal geometry of European adults.

PubMed

Bertrand, Samuel; Skalli, Wafa; Delacherie, Laurent; Bonneau, Dominique; Kalifa, Gabriel; Mitton, David

2006-12-15

The primary objective of the study was to bring a deeper knowledge of the human anthropometry, investigating the external and internal body geometry of small women, mid-sized men and tall men. Sixty-four healthy European adults were recruited. External measurements were performed using classical anthropometric instruments. Internal measurements of the trunk bones were performed using a stereo-radiographic 3D reconstruction technique. Besides the original procedure presented in this paper for performing in vivo geometrical data acquisition on numerous volunteers, this study provides an extensive description of both external and internal (trunk skeleton) human body geometry for three morphotypes. Moreover, this study proposes a global external and internal geometrical description of 5th female 50th male and 95th male percentile subjects. This study resulted in a unique geometrical database enabling improvement for numerical models of the human body for crash test simulation and offering numerous possibilities in the anthropometry field.

CpG-ODN Shapes Alum Adjuvant Activity Signaling via MyD88 and IL-10

PubMed Central

Mirotti, Luciana; Alberca Custódio, Ricardo Wesley; Gomes, Eliane; Rammauro, Florencia; de Araujo, Eliseu Frank; Garcia Calich, Vera Lucia; Russo, Momtchilo

2017-01-01

Aluminum-containing adjuvants usually referred as Alum are considered as T helper type-2 (Th2) adjuvants, while agonists of toll-like receptors (TLRs) are viewed as adjuvants that favor Th1/Th17 immunity. Alum has been used in numerous vaccine formulations; however, its undesired pro-Th2 adjuvant activity constitutes a caveat for Alum-based vaccines. Combining Alum with TLR-dependent, pro-Th1/Th17 adjuvants might dampen the pro-Th2 activity and improve the effectiveness of vaccine formulations. Here, using the ovalbumin (OVA) model of allergic lung inflammation, we found that sensitization with the synthetic TLR9 agonist, which is composed of oligodeoxynucleotides containing CpG motifs adsorbed to Alum, inhibited the development of OVA-induced lung allergic Th2 responses without shifting toward a Th1 pattern. The conversion of T cell immunity from the polarized allergic Th2 response to a non-polarized form by sensitization with OVA/Alum/CpG was dependent on MyD88 signaling in myeloid cells. Notably, sensitization of IL-10-deficient mice with OVA/Alum/CpG resulted in the development of neutrophilic lung inflammation associated with IFNγ production. However, in IL-10/IL-12-deficient mice, it resulted in neutrophilic inflammation dominated by IL-17 production. We conclude that OVA/Alum/CpG sensitization signaling via MyD88 and IL-10 molecules results in non-polarized immunity. Conversely, OVA/Alum/CpG sensitization in presence of MyD88 but absence of IL-10 or IL-10/IL-12 molecules results, respectively, in neutrophilic inflammation associated with IFNγ or IL-17 production. Our work provides novel OVA models of lung inflammation and suggests that Alum/CpG-based formulations might be of potential use in anti-allergic or anti-infectious processes. PMID:28220116

76 FR 2754 - Citizens Coinage Advisory Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-14

.... Time: 9 a.m. to 12 p.m. Location: 8th Floor Board Room, United States Mint, 801 9th Street, NW... CONTACT: Cliff Northup, United States Mint Liaison to the CCAC; 801 9th Street, NW.; Washington, DC 20220...

Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection.

PubMed

Licona-Limón, Paula; Henao-Mejia, Jorge; Temann, Angela U; Gagliani, Nicola; Licona-Limón, Ileana; Ishigame, Harumichi; Hao, Liming; Herbert, De'broski R; Flavell, Richard A

2013-10-17

Type 2 inflammatory cytokines, including interleukin-4 (IL-4), IL-5, IL-9, and IL-13, drive the characteristic features of immunity against parasitic worms and allergens. Whether IL-9 serves an essential role in the initiation of host-protective responses is controversial, and the importance of IL-9- versus IL-4-producing CD4⁺ effector T cells in type 2 immunity is incompletely defined. Herein, we generated IL-9-deficient and IL-9-fluorescent reporter mice that demonstrated an essential role for this cytokine in the early type 2 immunity against Nippostrongylus brasiliensis. Whereas T helper 9 (Th9) cells and type 2 innate lymphoid cells (ILC2s) were major sources of infection-induced IL-9 production, the adoptive transfer of Th9 cells, but not Th2 cells, caused rapid worm expulsion, marked basophilia, and increased mast cell numbers in Rag2-deficient hosts. Taken together, our data show a critical and nonredundant role for Th9 cells and IL-9 in host-protective type 2 immunity against parasitic worm infection. Copyright © 2013 Elsevier Inc. All rights reserved.

Sunspots sketches during the solar eclipses of 9th January and 29th December of 1777 in Mexico

NASA Astrophysics Data System (ADS)

Domínguez-Castro, Fernando; Gallego, María Cruz; Vaquero, José Manuel

2017-06-01

Two sunspot observations recorded by the Mexican Felipe de Zúñiga y Ontiveros have been revealed from a manuscript. One sunspot group was recorded on 9th January 1777 and four sunspot groups on 29th December 1777. Both records were taken during the observation of solar eclipses from Mexico City and their description also included sketches of the solar disk with sunspots. The sunspot group corresponding to 9th January was also observed by Erasmus Lievog. The observation on 29th December 1777 is the only record corresponding to this date.

A qualitative examination of health and health care utilization after the September 11th terror attacks among World Trade Center Health Registry enrollees.

PubMed

Welch, Alice E; Caramanica, Kimberly; Debchoudhury, Indira; Pulizzi, Allison; Farfel, Mark R; Stellman, Steven D; Cone, James E

2012-08-31

Many individuals who have 9/11-related physical and mental health symptoms do not use or are unaware of 9/11-related health care services despite extensive education and outreach efforts by the World Trade Center (WTC) Health Registry (the Registry) and various other organizations. This study sought to evaluate Registry enrollees' perceptions of the relationship between physical and mental health outcomes and 9/11, as well as utilization of and barriers to 9/11-related health care services. Six focus groups were conducted in January 2010 with diverse subgroups of enrollees, who were likely eligible for 9/11-related treatment services. The 48 participants were of differing race/ethnicities, ages, and boroughs of residence. Qualitative analysis of focus group transcripts was conducted using open coding and the identification of recurring themes. Participants described a variety of physical and mental symptoms and conditions, yet their knowledge and utilization of 9/11 health care services were low. Participants highlighted numerous barriers to accessing 9/11 services, including programmatic barriers (lack of program visibility and accessibility), personal barriers such as stigmatization and unfamiliarity with 9/11-related health problems and services, and a lack of referrals from their primary care providers. Moreover, many participants were reluctant to connect their symptoms to the events of 9/11 due to lack of knowledge, the amount of time that had elapsed since 9/11, and the attribution of current health symptoms to the aging process. Knowledge of the barriers to 9/11-related health care has led to improvements in the Registry's ability to refer eligible enrollees to appropriate treatment programs. These findings highlight areas for consideration in the implementation of the new federal WTC Health Program, now funded under the James Zadroga 9/11 Health and Compensation Act (PL 111-347), which includes provisions for outreach and education.

Reference intervals and percentiles for carotid-femoral pulse wave velocity in a healthy population aged between 9 and 87 years.

PubMed

Diaz, Alejandro; Zócalo, Yanina; Bia, Daniel; Wray, Sandra; Fischer, Edmundo Cabrera

2018-04-01

There is little information regarding age-related reference intervals (RIs) of carotid-femoral pulse wave velocity (cfPWV) for large healthy populations in South America. The aims of this study were to determine cfPWV RIs and percentiles in a cohort of healthy children, adolescents, and adults and to generate year-to-year percentile curves and body-height percentile curves for children and adolescents. cfPWV was measured in 1722 healthy participants with no cardiovascular risk factors (9-87 years, 60% men). First, RIs were evaluated for males and females through correlation and covariate analysis. Then, mean and standard deviation age-related equations were obtained for cfPWV using parametric regression methods based on fractional polynomials and age-specific (year-to-year) percentile curves that were defined using the standard normal distribution. Age-specific first, 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, 95th, 97.5th, and 99th percentile curves were calculated. Finally, height-related cfPWV percentile curves for children and adolescents (<21 years) were established. After adjusting for age and blood pressure differences with respect to females, males showed higher cfPWV levels (6.60 vs 6.45 m/s; P < .01). Thus, specific RIs for males and females were reported. The study provides the largest database to date concerning cfPWV in healthy people from Argentina. Specific RIs and percentiles of cfPWV are now available according to age and sex. Specific percentiles of cfPWV according to body height were reported for people younger than 21 years. ©2018 Wiley Periodicals, Inc.

Analysis of velocity and magnetic field fluctuations from simulated Solar Probe Plus measurements: Interpretation and predictions.

NASA Astrophysics Data System (ADS)

Perez, J. C.; Chandran, B. D. G.

2016-12-01

As Solar Probe Plus (SPP) explores the near-Sun environment, our ability to obtain meaningful interpretation of in-situ measurements faces two significant challenges. The first challenge is that the Taylor Hypothesis (TH), which is normally used in the interpretation of existing spacecraft data, breaks down at the low heliocentric distances that SPP mission will explore. The second challenge is our limited understanding of turbulence in this region, largely due to the theoretical and numerical difficulties in modeling this problem. In this work we present recent progress towards overcoming these challenges using high-resolution numerical simulations of Alfvenic turbulence in the inner heliosphere. We fly virtual SPP spacecraft in the simulation domain to obtain single-point measurements of the velocity and magnetic field fluctuations at several radial locations relevant to SPP. We use these virtual measurements to 1) validate a recently introduced modified TH that allows one to recover the spatial structure of the dominant (outward-propagating) Alfvenic fluctuations, of the kind SPP will encounter; and 2) to compare these virtual observations with our most recent phenomenological models of reflection-driven Alfven turbulence.

Comparison of Utility of Histogram Apparent Diffusion Coefficient and R2* for Differentiation of Low-Grade From High-Grade Clear Cell Renal Cell Carcinoma.

PubMed

Zhang, Yu-Dong; Wu, Chen-Jiang; Wang, Qing; Zhang, Jing; Wang, Xiao-Ning; Liu, Xi-Sheng; Shi, Hai-Bin

2015-08-01

The purpose of this study was to compare histogram analysis of apparent diffusion coefficient (ADC) and R2* for differentiating low-grade from high-grade clear cell renal cell carcinoma (RCC). Forty-six patients with pathologically confirmed clear cell RCC underwent preoperative BOLD and DWI MRI of the kidneys. ADCs based on the entire tumor volume were calculated with b value combinations of 0 and 800 s/mm(2). ROI-based R2* was calculated with eight TE combinations of 6.7-22.8 milliseconds. Histogram analysis of tumor ADCs and R2* values was performed to obtain mean; median; width; and fifth, 10th, 90th, and 95th percentiles and histogram inhomogeneity, kurtosis, and skewness for all lesions. Thirty-three low-grade and 13 high-grade clear cell RCCs were found at pathologic examination. The TNM classification and tumor volume of clear cell RCC significantly correlated with histogram ADC and R2* (ρ = -0.317 to 0.506; p < 0.05). High-grade clear cell RCC had significantly lower mean, median, and 10th percentile ADCs but higher inhomogeneity and median R2* than low-grade clear cell RCC (all p < 0.05). Compared with other histogram ADC and R2* indexes, 10th percentile ADC had the highest accuracy (91.3%) in discriminating low- from high-grade clear cell RCC. R2* in discriminating hemorrhage was achieved with a threshold of 68.95 Hz. At this threshold, high-grade clear cell RCC had a significantly higher prevalence of intratumor hemorrhage (high-grade, 76.9%; low-grade, 45.4%; p < 0.05) and larger hemorrhagic area than low-grade clear cell RCC (high-grade, 34.9% ± 31.6%; low-grade, 8.9 ± 16.8%; p < 0.05). A close relation was found between MRI indexes and pathologic findings. Histogram analysis of ADC and R2* allows differentiation of low- from high-grade clear cell RCC with high accuracy.

Vistas in applied mathematics: Numerical analysis, atmospheric sciences, immunology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balakrishnan, A.V.; Dorodnitsyn, A.A.; Lions, J.L.

1986-01-01

Advances in the theory and application of numerical modeling techniques are discussed in papers contributed, primarily by Soviet scientists, on the occasion of the 60th birthday of Gurii I. Marchuk. Topics examined include splitting techniques for computations of industrial flows, the mathematical foundations of the k-epsilon turbulence model, splitting methods for the solution of the incompressible Navier-Stokes equations, the approximation of inhomogeneous hyperbolic boundary-value problems, multigrid methods, and the finite-element approximation of minimal surfaces. Consideration is given to dynamic modeling of moist atmospheres, satellite observations of the earth radiation budget and the problem of energy-active ocean regions, a numerical modelmore » of the biosphere for use with GCMs, and large-scale modeling of ocean circulation. Also included are several papers on modeling problems in immunology.« less

Proceedings of the 9th Annual Conference on Manual Control

NASA Technical Reports Server (NTRS)

1973-01-01

Papers are reported which were presented at the conference in the areas of displays, ride qualities and handling, driving and psychomotor skills, control, system identification and signal detection, electrophysiological and systems analysis, and modelling.

Involvement of catecholaminergic neurons in motor innervation of striated muscle in the mouse esophagus.

PubMed

van der Keylen, Piet; Garreis, Fabian; Steigleder, Ruth; Sommer, Daniel; Neuhuber, Winfried L; Wörl, Jürgen

2016-05-01

Enteric co-innervation is a peculiar innervation pattern of striated esophageal musculature. Both anatomical and functional data on enteric co-innervation related to various transmitters have been collected in different species, although its function remains enigmatic. However, it is unclear whether catecholaminergic components are involved in such a co-innervation. Thus, we examined to identify catecholaminergic neuronal elements and clarify their relationship to other innervation components in the esophagus, using immunohistochemistry with antibodies against tyrosine hydroxylase (TH), vesicular acetylcholine transporter (VAChT), choline acetyltransferase (ChAT) and protein gene product 9.5 (PGP 9.5), α-bungarotoxin (α-BT) and PCR with primers for amplification of cDNA encoding TH and dopamine-β-hydroxylase (DBH). TH-positive nerve fibers were abundant throughout the myenteric plexus and localized on about 14% of α-BT-labelled motor endplates differing from VAChT-positive vagal nerve terminals. TH-positive perikarya represented a subpopulation of only about 2.8% of all PGP 9.5-positive myenteric neurons. Analysis of mRNA showed both TH and DBH transcripts in the mouse esophagus. As ChAT-positive neurons in the compact formation of the nucleus ambiguus were negative for TH, the TH-positive nerve varicosities on motor endplates are presumably of enteric origin, although a sympathetic origin cannot be excluded. In the medulla oblongata, the cholinergic ambiguus neurons were densely supplied with TH-positive varicosities. Thus, catecholamines may modulate vagal motor innervation of esophageal-striated muscles not only at the peripheral level via enteric co-innervation but also at the central level via projections to the nucleus ambiguus. As Parkinson's disease, with a loss of central dopaminergic neurons, also affects the enteric nervous system and dysphagia is prevalent in patients with this disease, investigation of intrinsic catecholamines in the esophagus may be worthwhile to understand such a symptom.

Battle Analysis: The Saar River Crossing

DTIC Science & Technology

1984-05-22

RAYMOND rlAJGR it»* *URT VANDERCLUTE MAJOR THOMAS WILSON CAPTAIN ROBERT MILLER CAPTAIN MAMA TRAORE (MALI) FOFT LEn^ENWORTH...turned over to Major Paul W. Marshall, of the 3!9th Engineers, who, in turn, received assistance from Major John N. Smith, Captain Thomas J. Mclntyre...possibility of the 11th PZ being released to secure Metz for a spring offensive. U*> The crossing of the 5e*r itself suceeded in diverting e*f*a#n r*s

Validation of the ICON-S staging for HPV-associated oropharyngeal carcinoma using a pre-defined treatment policy.

PubMed

Porceddu, Sandro V; Milne, Rob; Brown, Elizabeth; Bernard, Anne; Rahbari, Reza; Cartmill, Bena; Foote, Matthew; McGrath, Margaret; Coward, Jermaine; Panizza, Benedict

2017-03-01

To determine whether the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S) for HPV associated oropharyngeal carcinoma (HPV+OPC) is a better discriminator of overall survival (OS), compared with the 7th edition (7th Ed) AJCC/UICC TNM staging following curative radiotherapy (RT). The 5-year OS for all patients with non-metastatic (M0) p16-confirmed OPC treated between 2005 and 2015 was determined and grouped based on the 7th Ed AJCC/UICC TNM and ICON-S staging. A total of 279 patients met the inclusion criteria. The 5-year OS with the 7th Ed TNM classification were Stage I/II 88.9% (95% CI; 70.6-100%), Stage III 93.8% (95% CI; 85.9-100%), Stage IVa 86.4% (95% CI; 81.6-91.5%) and Stage IVb 62.3% (95% CI; 46.8-82.8%). On multivariate Cox regression analysis there was no statistically significant OS difference when comparing Stage I/II with, Stage III (p=0.98, HR=0.97, 95% CI; 0.11-8.64), IVa (p=0.67, HR=1.56, 95% CI; 0.2-11.94) and IVb (p=0.11, HR=5.54, 95% CI; 0.69-44.52), respectively. The 5-year OS with ICON-S staging were Stage I 93.6% (95% CI; 89.4-98.0%), Stage II 81.9% (95% CI; 73.7-91.1%) and Stage III 69.1% (95%; 57.9-82.6%). There was a consistent decrease of OS with increasing stage. On multivariate Cox regression analysis, when compared to Stage I, OS was significantly lower for stage II (p=0.007, HR=2.84, 95% CI; 1.33-6.05) and stage III (p<0.001, HR=3.78, 95% CI; 1.81-7.92), respectively. The ICON-S staging provides better OS stratification for HPV+OPC following RT compared with the 7th Ed TNM staging. Copyright © 2017 Elsevier Ltd. All rights reserved.

Perceptions of Teen Pregnancy among High School Students in Sweet Home, Oregon

ERIC Educational Resources Information Center

Little, Tim; Henderson, Jessica; Pedersen, Peggy; Stonecipher, Linda

2010-01-01

Background: The purpose of this study was to gain insights into the perceptions and attitudes about teen pregnancy among high school students in a rural area with high teen pregnancy rates. Methods: Five focus groups were conducted with: (1) females in 9th-10th grades; (2) females in 11th-12th grades; (3) males in 9th-10th grades; (4) males in…

Numerical Modeling of the Hydrothermal System at East Pacific Rise 9°50'N Including Anhydrite Precipitation

NASA Astrophysics Data System (ADS)

Kolandaivelu, K. P.; Lowell, R. P.

2015-12-01

To better understand the effects of anhydrite precipitation on mid-ocean ridge hydrothermal systems, we conducted 2-D numerical simulations of two-phase hydrothermal circulation in a NaCl-H2O fluid at the East Pacific Rise 9°50'N. The simulations were constrained by key observational thermal data and seismicity that suggests the fluid flow is primarily along axis with recharge focused into a small zone near a 4th order discontinuity. The simulations considered an open-top square box with a fixed seafloor pressure of 25 MPa, and nominal seafloor temperature of 10 °C. The sides of the box were assumed to be impermeable and insulated. We considered two models: a homogeneous model with a permeability of 10-13 m2 and a heterogeneous model in which layer 2A extrusives were given a higher permeability. Both models had a fixed bottom temperature distribution and initial porosity of 0.1. Assuming that anhydrite precipitation resulted from the decrease in solubility with increasing temperature as downwelling fluid gets heated, we calculated the rate of porosity decrease and sealing times in each cell at certain time snapshots in the simulations. The results showed that sealing would occur most rapidly in limited regions near the base of the high-temperature plumes, where complete sealing could occur on decadal time scales. Though more detailed analysis is needed, it appeared that the areas of rapid sealing would likely have negligible impact on the overall circulation pattern and hydrothermal vent temperatures. The simulations also indicated that sealing due to anhydrite precipitation would occur more slowly at the margins of the ascending plumes. The sealing times in the deep recharge zone determined in these simulations were considerably greater than estimated from 1D analytical calculations, suggesting that with a 2D model, focused recharge at the EPR 9°50'N site may occur, at least on a decadal time scale.

International Symposium on Numerical Methods in Engineering, 5th, Ecole Polytechnique Federale de Lausanne, Switzerland, Sept. 11-15, 1989, Proceedings. Volumes 1 & 2

NASA Astrophysics Data System (ADS)

Gruber, Ralph; Periaux, Jaques; Shaw, Richard Paul

Recent advances in computational mechanics are discussed in reviews and reports. Topics addressed include spectral superpositions on finite elements for shear banding problems, strain-based finite plasticity, numerical simulation of hypersonic viscous continuum flow, constitutive laws in solid mechanics, dynamics problems, fracture mechanics and damage tolerance, composite plates and shells, contact and friction, metal forming and solidification, coupling problems, and adaptive FEMs. Consideration is given to chemical flows, convection problems, free boundaries and artificial boundary conditions, domain-decomposition and multigrid methods, combustion and thermal analysis, wave propagation, mixed and hybrid FEMs, integral-equation methods, optimization, software engineering, and vector and parallel computing.

NASA's Pleiades Supercomputer Crunches Data For Groundbreaking Analysis and Visualizations

NASA Image and Video Library

2016-11-23

The Pleiades supercomputer at NASA's Ames Research Center, recently named the 13th fastest computer in the world, provides scientists and researchers high-fidelity numerical modeling of complex systems and processes. By using detailed analyses and visualizations of large-scale data, Pleiades is helping to advance human knowledge and technology, from designing the next generation of aircraft and spacecraft to understanding the Earth's climate and the mysteries of our galaxy.

Supercomputing '91; Proceedings of the 4th Annual Conference on High Performance Computing, Albuquerque, NM, Nov. 18-22, 1991

NASA Technical Reports Server (NTRS)

1991-01-01

Various papers on supercomputing are presented. The general topics addressed include: program analysis/data dependence, memory access, distributed memory code generation, numerical algorithms, supercomputer benchmarks, latency tolerance, parallel programming, applications, processor design, networks, performance tools, mapping and scheduling, characterization affecting performance, parallelism packaging, computing climate change, combinatorial algorithms, hardware and software performance issues, system issues. (No individual items are abstracted in this volume)

The Impact of School-to-School Transitions on Academic Achievement: An Analysis of Various Grade-Span Configurations Utilized by Public School Districts in New York State

ERIC Educational Resources Information Center

DelViscio, James J.

2013-01-01

At the beginning of the 20th century, there were essentially two types of organizational structures for primary and secondary education in the United States. There were either one-room K-12 schools or in larger systems K-8 buildings feeding into four-year high schools. Despite numerous experiments since then in reconfiguring schools resulting in a…

Quantitative Weather Impacts: An Integrated Weather Effects Decision Aid Impact Magnitude Gradation Scheme and Friendly Versus Threat Delta Advantage

DTIC Science & Technology

2013-08-01

FV_RED 600 (9,9) –0.0010 3.0000 2.40 2.40 FV_MAX_RED_TH 0 (4,9) –0.0010 3.0000 3.00 3.00 FV_EXCEED_MAX_RED_TH NAa –0.0010 3.0000 NA NA a Since...0.46)] MIV MIV FV and (Array Row, Column) FV_<_ZERO_IMPACT_TH NAa NA NA FV_ZERO_IMPACT_TH 0.00 (0,0) 9.0909 0.0000 0.00 0.00 FV_GREEN 0.10

Stress in Portuguese Middle School Transition: A Multilevel Analysis.

PubMed

Coelho, Vítor Alexandre; Romão, Ana Maria

2016-09-23

Transition from elementary to middle school is commonly seen as a period of stress, impacting students' school adjustment. The present longitudinal study aimed to analyze the difference in stress levels between the end of 4th grade and 5th grade, while also analyzing gender differences and 5th grade retention. Two hundred fifty-eight 4th grade students (M age = 9.55; SD = 0.77) from six Portuguese public schools, from the municipality of Torres Vedras, participated in this study. Self-report questionnaires were administered at the end of the 4th and 5th grades, and 5th grade school records were also collected. Results showed that 5th graders present higher levels of Academic Stress (d = .29) and Teacher/Rules Stress (d = .28). Girls had a greater increase of Peer-related Stress with the transition (p < .01). Students who were retained at the end of 5th grade showed higher increases of Teacher/Rules Stress (p < .05). Intervention programs that aim to support the transition from elementary to middle school are needed, in order to reduce the increase of stress levels at 5th grade and to promote a better school adjustment in the first year of middle school.

[Changes in peripheral blood T helper 9 cells and interleukin-9 in children in the acute stage of Kawasaki disease].

PubMed

Sun, Rui-Li; Zhu, Shu-Xia; Zhang, Yan-Yan; Wu, Yi-Fei; Wang, Xing-Jian

2016-08-01

To investigate the changes in the expression levels of peripheral blood T helper 9 (Th9) cells and cytokine interleukin-9 (IL-9) in children in the acute stage of Kawasaki disease (KD) and their clinical significance. A total of 45 children in the acute stage of KD who were treated from April 2014 to July 2015 were enrolled, and the children were followed up in the recovery stage. Another 45 healthy children who underwent physical examination were enrolled as the control group. Flow cytometry was used to measure the percentage of peripheral blood Th9 cells, and ELISA was used to measure the serum level of IL-9. The children in the acute stage of KD showed a significantly higher percentage of Th9 cells and a significantly higher serum level of IL-9 compared with those in the recovery stage and the control group (P<0.05). The percentage of Th9 cells and serum level of IL-9 showed no significant differences between the children in the recovery stage and those in the control group (P>0.05). In the acute stage, the percentage of Th9 cells was positively correlated with the levels of IL-9, C-reactive protein (CRP), procalcitonin (PCT), erythrocyte sedimentation rate (ESR), platelet count (PLT), and globulin (r=0.624, 0.324, 0.402, 0.382, 0.467, and 0.386 respectively, all P<0.05), but negatively correlated with serum albumin (r=-0.306, P<0.05). The serum level of IL-9 was positively correlated with the levels of CRP, PCT, ESR, PLT, and globulin (r=0.365, 0.456, 0.403, 0.423, and 0.453 respectively, all P<0.05), but negatively correlated with serum albumin (r=-0.343, P<0.05). The children in the acute stage of KD show significant increases in the percentage of peripheral Th9 cells and serum cytokine IL-9 level, which return to normal in the recovery stage. In the acute stage of KD, the expression levels of Th9 and IL-9 are closely correlated with laboratory markers. The results suggest that Th9 cells and IL-9 play important roles in the pathogenesis and outcome of KD.

Aircraft accidents by older persons.

DOT National Transportation Integrated Search

1967-10-01

During 1965 there were 450,494 certificated general aviation pilots in the United States, of which 9,826 were over sixty years old. Within this group there were 108 accidents, 17 of which were fatal. Statistical analysis (chi square) revealed that th...

20. TYPICAL VIEW OF FRONT WINDOWS FROM 4TH TO 9TH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. TYPICAL VIEW OF FRONT WINDOWS FROM 4TH TO 9TH FLOOR WITH WHITE GLAZED TERRA COTTA SILL AND HEADERS. MULLIONS ARE ORANGE BROWN BRICKS LIKE THE WALLS. BRICKS ARE IN FLEMISH BOND PATTERN. - Pacific Telephone & Telegraph Company Building, 1519 Franklin Street, Oakland, Alameda County, CA

Familial Xp22.33-Xp22.12 deletion delineated by chromosomal microarray analysis causes proportionate short stature.

PubMed

Cho, Sung Yoon; Ki, Chang-Seok; Jang, Ja-Hyun; Sohn, Young Bae; Park, Sung Won; Kim, Se Hwa; Kim, Su Jin; Jin, Dong-Kyu

2012-06-01

Patients with Xp deletions have short stature and may have some somatic traits typical of Turner syndrome (TS), whereas gonadal function is generally preserved. In most studies of these patients, microsatellites have been used to determine the break point of the Xp deletion. In the present study, we describe the clinical, cytogenetic, and chromosomal microarray (CMA) analysis of a family with an Xp22.33-Xp22.12 deletion. Two female siblings, aged 8 years 9 months and 11 years 10 months, presented with short stature. The older sibling's height (index case) was 137.9 cm (-1.81 SDS) and the younger sibling's height was 118.6 cm (-2.13 SDS). The mother and both daughters had only a short stature; a skeletal survey showed normal findings except for mildly shortened 4th and 5th metacarpal bones. No features of TS were present. The deletion appeared terminal with a breakpoint within Xp22.2 located about 19.9 Mb from the Xp telomere. The deletion contained 102 protein-coding genes. A probe of the end breakage point was located at the 19,908,986th base of the X chromosome, and a probe of the marginal normal region near the breakage point was located at the 19,910,848th base of the X chromosome. Therefore, the breakage point was concluded to be located between these two probes. In summary, we report a familial case of an Xp deletion. The findings of our study may be helpful in further analyzing the phenotypes associated with Xp deletions. Copyright © 2012 Wiley Periodicals, Inc.

A Mechanism to Enhance Cellular Responsivity to Hormone Action: Krüppel-Like Factor 9 Promotes Thyroid Hormone Receptor-β Autoinduction During Postembryonic Brain Development

PubMed Central

Hu, Fang; Knoedler, Joseph R.

2016-01-01

Thyroid hormone (TH) receptor (TR)-β (trb) is induced by TH (autoinduced) in Xenopus tadpoles during metamorphosis. We previously showed that Krüppel-like factor 9 (Klf9) is rapidly induced by TH in the tadpole brain, associates in chromatin with the trb upstream region in a developmental stage and TH-dependent manner, and forced expression of Klf9 in the Xenopus laevis cell line XTC-2 accelerates and enhances trb autoinduction. Here we investigated whether Klf9 can promote trb autoinduction in tadpole brain in vivo. Using electroporation-mediated gene transfer, we transfected plasmids into premetamorphic tadpole brain to express wild-type or mutant forms of Klf9. Forced expression of Klf9 increased baseline trb mRNA levels in thyroid-intact but not in goitrogen-treated tadpoles, supporting that Klf9 enhances liganded TR action. As in XTC-2 cells, forced expression of Klf9 enhanced trb autoinduction in tadpole brain in vivo and also increased TH-dependent induction of the TR target genes klf9 and thbzip. Consistent with our previous mutagenesis experiments conducted in XTC-2 cells, the actions of Klf9 in vivo required an intact N-terminal region but not a functional DNA binding domain. Forced expression of TRβ in tadpole brain by electroporation-mediated gene transfer increased baseline and TH-induced TR target gene transcription, supporting a role for trb autoinduction during metamorphosis. Our findings support that Klf9 acts as an accessory transcription factor for TR at the trb locus during tadpole metamorphosis, enhancing trb autoinduction and transcription of other TR target genes, which increases cellular responsivity to further TH action on developmental gene regulation programs. PMID:26886257

Adolescent obesity adversely affects blood pressure and resting heart rate.

PubMed

Baba, Reizo; Koketsu, Masaaki; Nagashima, Masami; Inasaka, Hiroshi; Yoshinaga, Masao; Yokota, Mitsuhiro

2007-05-01

Obesity is associated with hypertension (HT) and high resting heart rate (HR), as well as metabolic disturbances. However, little is known about how strongly these hemodynamic abnormalities are associated with the degree of obesity in adolescents. Height, body weight, resting HR, and systolic and diastolic blood pressures were measured in 20,165 male and 19,683 female high-school students. Adiposity levels were classified into 6 groups by body mass index: group 1 (<20th percentile), group 2 (20th-39.9th percentile), group 3 (40th-59.9th percentile), group 4 (60th-79.9th percentile), group 5 (80th-98.9th percentile), and group 6 (> or =99th percentile). Systolic and diastolic hypertensions were defined as > or =140 mmHg and > or =85 mmHg, respectively. Resting tachycardia was defined as the corresponding 95th percentile or greater. Resting HR and systolic and diastolic blood pressures increased with adiposity level in both sexes (p<0.0001). Both systolic HT and diastolic HT were associated with high resting HR, and the clustering of these unfavorable conditions increased with the degree of obesity. Hemodynamic abnormalities, such as HT and a high resting HR, are closely associated with adolescent obesity and are probably explained by impaired autonomic nerve function.

Analysis of Carbon Fiber’s X-Ray Microscopic Structure

DTIC Science & Technology

1989-08-16

this translation were extracted from the best quality copy available. Aecesslem For icr: S SRA&I1 STIC TAB Una-oun ced Just Ifleatlo By D st ri lutI am...22, No. 5, 1968 FagES Tra1;slatez: 20-2"- r - r r,. s f-~ 1~ 2022’-D(( S -EE~3 Lec Kanner Associates V~.Bcx 517 s:c: d Citv C.A 9 4 0’ ANALYSIS OF...diffraction for fac_ (002) is es eciallv intense, with th, inter-face distance equal to 1/2 Je th carbmn fiber’s lattice constan. Becau2 iz - s

Tapered chalcogenide-tellurite hybrid microstructured fiber for mid-infrared supercontinuum generation

NASA Astrophysics Data System (ADS)

Yang, Peilong; Zhang, Peiqing; Dai, Shixun; Wu, Yuehao; Wang, Xunsi; Tao, Guangming; Nie, Qiuhua

2015-05-01

Fibers exhibiting flattened and decreasing dispersion are important in nonlinear applications. Such fibers are difficult to design, particularly in soft glass. In this work, we develop a preliminary design of a highly nonlinear tapered hybrid microstructured optical fiber (TH-MOF) with chalcogenide glass core and tellurite glass microstructure cladding. We then numerically studied its dispersion, loss, and nonlinearity-related optical properties under fundamental mode systematically using the infinitesimal method. The designed TH-MOF exhibits low chromatic dispersion that is similar to a convex function with two zero-dispersion wavelengths and decreases with fiber length from 2 to 5 μm band. The potential use of the TH-MOF in nonlinear applications is demonstrated numerically by a supercontinuum spectrum of 20 dB bandwidth covering 1.96-4.76 μm generated in 2-cm-long TH-MOF using near 3.25-μm fs-laser pump.

Public health and social supervision issues within public administration of ukrainian territories in the late 8th- early 9th centuries.

PubMed

Hrynzovskyi, Anatolii M; Holovanova, Irina A; Omelchuk, Sergei T; Kuzminska, Olena V; Hrynzovska, Anastasia A; Karlova, Olena O; Kondratiuk, Vitalii Ye

Introduction: The public health system modernization history is based upon the progress in state country administration and administration of healthcare within the sectorwide approach. The WHO European Bureau pays much attention to the National Health Service systems development while implementing their basic policies. The Ukrainian state health service management was founded basing on the regulatory field of the Russian Empire, using the European healthcare promotion experience. Aim: of the article is the analysis of the regulatory field of police and amenity authorities of the Russian Empire and Ukraine within the medical and social service in the 18th-19th centuries. Materials and methods: The structure of the article corresponds to the problem city and chronology principles, using the following methods and techniques of scientific learning: the systemic, historic, regulatory comparative, logical and structural-functional analysis of the studied medical-legal phenomena. The study sources are the scientific publications, collections of laws and executive orders of the Russian Empire and Ukraine in the 18th-19th centuries. Review: As a result of the performed work it can be determined were the main directions of the police competence in late 18th- early 19th centuries. Conclusion: Preserving health, treatment of the ill and injured, management of medical and social service of those in need, holding various preventive activities and supporting safe environment and regulating the safety of food were the main directions of the police competence in late 18th- early 19th centuries.

Th9 Cells: Probable players in ulcerative colitis pathogenesis.

PubMed

Shohan, Mojtaba; Elahi, Shokrollah; Shirzad, Hedayatollah; Rafieian-Kopaei, Mahmoud; Bagheri, Nader; Soltani, Emad

2018-04-19

T lymphocytes represent an important part of adaptive immune system undertaking different functions to regulate immune responses. CD4+ T cells are the most important activator cells in inflammatory conditions. Depending on the type of induced cells and inflamed sites, expression and activity of different subtypes of helper T cells are changed. Recent studies have confirmed the existence of a new subset of helper T lymphocytes called Th9. Naive T cells can differentiate into Th9 subtypes if they are exposed simultaneously by interleukin (IL) 4 and transforming growth factor β and also secondary activation of a complicated network of transcription factors such as interferon regulatory factor 4 (IRF4) and Smads which are essential for adequate induction of this phenotype. Th9 cells specifically produce interleukin 9 and their probable roles in promoting intestinal inflammation are being investigated in human subjects and experimental models of ulcerative colitis (UC). Recently, infiltration of Th9 cells, overexpression of IL-9, and certain genes associated with Th9 differentiation have been demonstrated in inflammatory microenvironment of UC. Intestinal oversecretion of IL-9 protein is likely to break down epithelial barriers and compromise tolerance to certain commensal microorganisms which leads to inflammation. Th9 pathogenicity has not yet been adequately explored in UC and they are far from being considered as inflammatory cells in this milieu, therefore precise understanding the role of these newly identified cells in particular their potential role in gut pathogenesis may enable us to develop novel therapeutic approaches for inflammatory bowel disease. So, this article tries to discuss the latest knowledge on the above-mentioned field.

Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree.

PubMed

Yıldırım, Tuba Talo; Kaya, Filiz Acun; Taşkesen, Mustafa; Dündar, Serkan; Bozoğlan, Alihan; Tekin, Gülücağ Giray; Akdeniz, Sedat

2017-01-01

Talo-Yıldırım T, Acun-Kaya F, Taşkesen M, Dündar S, Bozoğlan A, Tekin GG, Akdeniz S. Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree. Turk J Pediatr 2017; 59: 56-61. Kindler syndrome (KS) is a rare genetic disorder. The clinical features include aggressive periodontal disease and severe desquamative gingivitis. Five individuals with KS were assessed by oral examination, radiographic analysis and periodontal measurements. All the patients' indexes were recorded prior to periodontal treatment and at the end of the 1th, 3th , 6th, 9th and 12th month respectively. All the patients had improvement of periodontal status and enhancement in index scores. The affected individuals were previously screened for FERMT1 mutations. KS patients' periodontal disease activity could be taken under control with regular follow-up.

Evaluation of a Myopic Normative Database for Analysis of Retinal Nerve Fiber Layer Thickness.

PubMed

Biswas, Sayantan; Lin, Chen; Leung, Christopher K S

2016-09-01

Analysis of retinal nerve fiber layer (RNFL) abnormalities with optical coherence tomography in eyes with high myopia has been complicated by high rates of false-positive errors. An understanding of whether the application of a myopic normative database can improve the specificity for detection of RNFL abnormalities in eyes with high myopia is relevant. To evaluate the diagnostic performance of a myopic normative database for detection of RNFL abnormalities in eyes with high myopia (spherical equivalent, -6.0 diopters [D] or less). In this cross-sectional study, 180 eyes with high myopia (mean [SD] spherical equivalent, -8.0 [1.8] D) from 180 healthy individuals were included in the myopic normative database. Another 46 eyes with high myopia from healthy individuals (mean [SD] spherical equivalent, -8.1 [1.8] D) and 74 eyes from patients with high myopia and glaucoma (mean [SD] spherical equivalent, -8.3 [1.9] D) were included for evaluation of specificity and sensitivity. The 95th and 99th percentiles of the mean and clock-hour circumpapillary RNFL thicknesses and the individual superpixel thicknesses of the RNFL thickness map measured by spectral-domain optical coherence tomography were calculated from the 180 eyes with high myopia. Participants were recruited from January 2, 2013, to December 30, 2015. The following 6 criteria of RNFL abnormalities were examined: (1) mean circumpapillary RNFL thickness below the lower 95th or (2) the lower 99th percentile; (3) one clock-hour or more for RNFL thickness below the lower 95th or (4) the lower 99th percentile; and (5) twenty contiguous superpixels or more of RNFL thickness in the RNFL thickness map below the lower 95th or (6) the lower 99th percentile. Specificities and sensitivities for detection of RNFL abnormalities. Of the 46 healthy eyes and 74 eyes with glaucoma studied (from 39 men and 38 women), the myopic normative database showed a higher specificity (63.0%-100%) than did the built-in normative database of the optical coherence tomography instrument (8.7%-87.0%) for detection of RNFL abnormalities across all the criteria examined (differences in specificities between 13.0% [95% CI, 1.1%-24.9%; P = .01] and 54.3% [95% CI, 37.8%-70.9%; P < .001]) except for the criterion of mean RNFL thickness below the lower 99th percentile, in which both normative databases had the same specificities (100%) but the myopic normative database exhibited a higher sensitivity (71.6% vs 86.5%; difference in sensitivities, 14.9% [95% CI, 4.6%-25.1%; P = .002]). The application of a myopic normative database improved the specificity without compromising the sensitivity compared with the optical coherence tomography instrument's built-in normative database for detection of RNFL abnormalities in eyes with high myopia. Inclusion of myopic normative databases should be considered in optical coherence tomography instruments.

Synergistically increased ILC2 and Th9 cells in lung tissue jointly promote the pathological process of asthma in mice.

PubMed

Ying, Xinyu; Su, Zhaoliang; Bie, Qingli; Zhang, Pan; Yang, Huijian; Wu, Yumin; Xu, Yunyun; Wu, Jing; Zhang, Mengying; Wang, Shengjun; Xu, Huaxi

2016-06-01

In recent years, T helper (Th) 9 cells have been demonstrated to be key mediators in immune responses in asthmatic lungs, and innate lymphoid cells 2 (ILC2s) have been described as a novel type of innate immunocyte with the ability to enhance immunoglobulin E (IgE) production. However, the interaction between ILC2s and Th9 cells in the pulmonary system of a mouse model of asthma remains to be elucidated. In the present study, the response state of lung tissue with regards to Th9 and ILC2s in a mouse model of asthma was investigated by detecting Th9‑ and ILC2‑associated cytokine receptors. The present study also investigated the association between the expression levels of the cytokine receptors in lung tissue samples and the IgE levels in sera samples from mouse models of asthma. Results from the present study demonstrated that the frequency of ILC2s and Th9 cells was significantly increased in the lung tissue samples, indicating that a Th2-type immune response had occurred. In addition, high mRNA expression levels of RAR‑related orphan receptor α, interleukin 1 receptor‑like 1, transcription factor PU.1 and interleukin (IL)‑9 were observed. Furthermore, IL‑5Rα, IL‑13Rα2 and high‑affinity IgE receptor were increased in mouse models of asthma, and a positive association was observed between the expression levels of ILC2‑ or Th9‑associated receptors in tissue samples and IgE levels in the sera. This indicated that ILC2s and Th9 were in a state of polarization and may promote each other in the lung tissue of mouse models of asthma, and that the lung tissue was responding to the two types of cells via increased expression of receptors.

Th9 and other IL-9-producing cells in allergic asthma.

PubMed

Koch, Sonja; Sopel, Nina; Finotto, Susetta

2017-01-01

Allergic asthma is a worldwide increasing chronic disease of the airways which affects more than 300 million people. It is associated with increased IgE, mast cell activation, airway hyperresponsiveness (AHR), mucus overproduction and remodeling of the airways. Previously, this pathological trait has been associated with T helper type 2 (Th2) cells. Recently, different CD4 + T cell subsets (Th17, Th9) as well as cells of innate immunity, like mast cells and innate lymphoid cells type 2 (ILC2s), which are all capable of producing the rediscovered cytokine IL-9, are known to contribute to this disease. Regarding Th9 cells, it is known that naïve T cells develop into IL-9-producing cells in the presence of interleukin-4 (IL-4) and transforming growth factor beta (TGFβ). Downstream of IL-4, several transcription factors like signal transducer and activator of transcription 6 (STAT6), interferon regulatory factor 4 (IRF4), GATA binding protein 3 (GATA3), basic leucine zipper transcription factor, ATF-like (BATF) and nuclear factor of activated T cells (NFAT) are activated. Additionally, the transcription factor PU.1, which is downstream of TGFβ signaling, also seems to be crucial in the development of Th9 cells. IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma.

Developmental and Individual Differences in Pure Numerical Estimation

ERIC Educational Resources Information Center

Booth, Julie L.; Siegler, Robert S.

2006-01-01

The authors examined developmental and individual differences in pure numerical estimation, the type of estimation that depends solely on knowledge of numbers. Children between kindergarten and 4th grade were asked to solve 4 types of numerical estimation problems: computational, numerosity, measurement, and number line. In Experiment 1,…

76 FR 60112 - Culturally Significant Objects Imported for Exhibition Determinations: “Byzantium and Islam: Age...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

... DEPARTMENT OF STATE [Public Notice 7615] Culturally Significant Objects Imported for Exhibition Determinations: ``Byzantium and Islam: Age of Transition (7th-9th Century)'' SUMMARY: Notice is hereby given of... included in the exhibition ``Byzantium and Islam: Age of Transition (7th-9th Century),'' imported from...

Preferential susceptibility of Th9 and Th2 CD4+ T cells to X4-tropic HIV-1 infection.

PubMed

Orlova-Fink, Nina; Chowdhury, Fatema Z; Sun, Xiaoming; Harrington, Sean; Rosenberg, Eric S; Yu, Xu G; Lichterfeld, Mathias

2017-10-23

The functional polarization of CD4 T cells determines their antimicrobial effector profile, but may also impact the susceptibility to infection with HIV-1. Here, we analyzed the susceptibility of CD4 T cells with different functional polarization to infection with X4 and R5-tropic HIV-1. CD4 T cells with a Th1, Th2, Th17, and Th9 polarization were subjected to in-vitro infection assays with X4, R5, or vesicular stomatitis virus-G protein-pseudotyped HIV-1. In addition, we sorted differentially polarized CD4 T-cell subsets from individuals treated with antiretroviral therapy and analyzed the tropism of viral env sequences. Th9-polarized CD4 T cells and, to a lesser extent, Th2-polarized CD4 T cells expressed higher surface levels of CXCR4, and are more permissive to X4-tropic infection in vitro. In contrast, Th1 and Th17 CD4 T cells exhibited stronger surface expression of CCR5, and were more susceptible to infection with R5-tropic viruses. Correspondingly, the distribution of X4-tropic viral sequences in antiretroviral therapy-treated HIV-1-infected patients was biased toward Th9/Th2 cells, whereas R5-tropic sequences were more frequently observed in Th17 cells. CD4 T-cell polarization is associated with a distinct susceptibility to X4 and R5-tropic HIV-1 infection.

9th Annual Systems Engineering Conference: Volume 4 Thursday

DTIC Science & Technology

2006-10-26

Connectivity, Speed, Volume • Enterprise application integration • Workflow integration or multi-media • Federated search capability • Link analysis and...categorization, federated search & automated discovery of information — Collaborative tools to quickly share relevant information Built on commercial

Hybrid accretion disks in active galactic nuclei. I - Structure and spectra

NASA Technical Reports Server (NTRS)

Wandel, Amri; Liang, Edison P.

1991-01-01

A unified treatment is presented of the two distinct states of vertically thin AGN accretion disks: a cool (about 10 to the 6th K) optically thick solution, and a hot (about 10 to the 9th K) optically thin solution. A generalized formalism and a new radiative cooling equation valid in both regimes are introduced. A new luminosity limit is found at which the hot and cool alpha solutions merge into a single solution of intermediate optical depth. Analytic solutions for the disk structure are given, and output spectra are computed numerically. This is used to demonstrate the prospect of fitting AGN broadband spectra containing both the UV bump as well as the hard X-ray and gamma-ray tail, using a single accretion disk model. Such models are found to make definite predictions about the observed spectrum, such as the relation between the hard X-ray spectral index, the UV-to-X-ray luminosity ratio, and a feature of about 1 MeV.

IL-4 and IL-13 Compromise the Sinonasal Epithelial Barrier and Perturb Intercellular Junction Protein Expression

PubMed Central

Wise, Sarah K.; Laury, Adrienne M.; Katz, Elizabeth H.; Den Beste, Kyle A.; Parkos, Charles A.; Nusrat, Asma

2014-01-01

Introduction Altered expression of epithelial intercellular junction proteins has been observed in sinonasal biopsies from nasal polyps and epithelial layers cultured from nasal polyp patients. These alterations comprise a “leaky” epithelial barrier phenotype. We hypothesize that Th2 cytokines IL-4 and IL-13 modulate epithelial junction proteins thereby contributing to the leaky epithelial barrier. Methods Differentiated primary sinonasal epithelial layers cultured at the air-liquid interface were exposed to IL-4, IL-13, and controls for 24 hours at 37°C. Epithelial resistance measurements were taken every 4 hours during cytokine exposure. Western blot and immunofluorescence staining/confocal microscopy were used to assess changes in a panel of tight and adherens junction proteins. Western blot densitometry was quantified with image analysis. Results IL-4 and IL-13 exposure resulted in a mean decrease in transepithelial resistance at 24 hours to 51.6% (n=6) and 68.6% (n=8) of baseline, respectively. Tight junction protein JAM-A expression decreased 42.2% with IL-4 exposure (n=9) and 37.5% with IL-13 exposure (n=9). Adherens junction protein E-cadherin expression decreased 35.3% with IL-4 exposure (n=9) and 32.9% with IL-13 exposure (n=9). Tight junction protein claudin-2 showed more variability but had a trend toward higher expression with Th2 cytokine exposure. There were no appreciable changes in claudin-1, occludin, or ZO-1 with IL-4 or IL-13 exposure. Conclusion Sinonasal epithelial exposure to Th2 cytokines IL-4 and IL-13 results in alterations in intercellular junction proteins, reflecting increased epithelial permeability. Such changes may explain some of the phenotypic manifestations of Th2-mediated sinonasal disease, such as edema, nasal discharge, and environmental reactivity. PMID:24510479

Effect of temperature on immune response of Japanese flounder (Paralichthys olivaceus) to inactivated lymphocystis disease virus (LCDV).

PubMed

Xu, Guojing; Sheng, Xiuzhen; Xing, Jing; Zhan, Wenbin

2011-02-01

Using flow cytometric analysis, the dynamics of surface immunoglobulin positive (sIg+) cells in lymphoid organs of Japanese flounder (Paralichthys olivaceus) reared at 9, 15, 21 and 26 °C, was investigated following intraperitoneal injection with inactivated lymphocystis disease virus (LCDV). The results showed that the percentages of sIg+ cells were suppressed in peripheral blood leucocytes (PBL), spleen leucocytes (SL) and head kidney leucocytes (HKL) from 9 °C to 15 °C immunized groups, and arrived at their peaks (9 °C: 26.12% in PBL, 18.84% in SL, 17.53% in HKL; 15 °C: 38.82% in PBL, 25.38% in SL, 23.95% in HKL) at 9th and 7th week after immunization, respectively. While the proportions of sIg+ cells in PBL, SL and HKL increased most prominent in the 21 °C group and reached the peaks (54.16% in PBL, 30.32% in SL, 30.23% in HKL) at 5th week. The responses of sIg+ cells from 26 °C group were similar to that from 21 °C group and reached the peaks (35.3% in PBL, 26.24% in SL, 21.83% in HKL) at 5th week. Simultaneously, the kinetics of the specific antibody titer against LCDV in sera was determined. It was shown that the antibody response in the 21 °C group was most prominent and reached the peak earliest. These results indicated inactivated LCDV elicited the most powerful immune response when Japanese flounder maintained at the optimal temperature (21 °C) and obtained the most effective immunization, while the response were suppressed at 9 °C, 15 °C or 26 °C. Copyright © 2010 Elsevier Ltd. All rights reserved.

Propellant Nonlinear Constitutive Theory Extension: Preliminary Results.

DTIC Science & Technology

1983-08-01

Farris, R. J., Hermann , L. R., Hutchinson, J. R., and Schapery, R. A., "Development of a Solid Rocket Propellant Nonlinear Viscoelastic Constitu- tive...Publication 331, Dec. 1980. pp. 127- 133. 27. Mullins, L., "Softening of Rubber by Deformation," Rubber Chem. Technol., 1969, Vol. 31, pp. 333-362. 28. Oberth ...June 1973. 30. Hermann , L. R., and Peterson, F. E., "A Numerical Procedure for Viscoelastic Stress Analysis," Proc. 7th Mtg. of ICRPG Mech. Beh

Seasonal and cumulative loblolly pine development under two stand density and fertility levels through four growing seasons

Treesearch

James D. Haywood

1994-01-01

A loblolly pine stand was subjected to two cultural treatments to determine treatment effects in the 9th through 12th growing seasons. Thining resulted in less spring height growth in the 9th and 10th growing seasons than no thinning, but thinning resulted in more diameter growth each year. Fertilization increased height and diameter growth beginning in the 10th...

Global perspectives on poisonous plants: The 9th International Symposium on Poisonous Plants

USDA-ARS?s Scientific Manuscript database

The 9th International Symposium on Poisonous Plants (ISOPP9) was held from 15th-21st July, 2013, at the Inner Mongolia Agricultural University in Hohhot, Inner Mongolia Autonomous Region of China. The Symposium consisted of three days of oral and poster presentations, followed by a tour of the Xilin...

Numerical methods in laminar and turbulent flow; Proceedings of the 7th International Conference, Stanford Univ., CA, July 15-19, 1991. Vol. 7, pts. 1 & 2

NASA Technical Reports Server (NTRS)

Taylor, C. (Editor); Chin, J. H. (Editor); Homsy, G. M. (Editor)

1991-01-01

Consideration is given to the impulse response of a laminar boundary layer and receptivity; numerical transition to turbulence in plane Poiseuille flow; large eddy simulation of turbulent wake flow; a viscous model and loss calculation of a multisplitter cascade; vortex initiation during dynamic stall of an airfoil; a numerical analysis of isothermal flow in a combustion chamber; and compressible flow calculations with a two-equation turbulence model and unstructured grids. Attention is also given to a 2D calculation of a buoyant flow around a burning sphere, a fast multigrid method for 3D turbulent incompressible flows, a streaming flow induced by an oscillating cascade of circular cylinders, an algebraic multigrid scheme for solving the Navier-Stokes equations on unstructured meshes; and nonlinear coupled multigrid solutions to thermal problems employing different nodal grid arrangements and convective transport approximations.

Numerical analysis and experimental verification of elastomer bending process with different material models

NASA Astrophysics Data System (ADS)

Kut, Stanislaw; Ryzinska, Grazyna; Niedzialek, Bernadetta

2016-01-01

The article presents the results of tests in order to verifying the effectiveness of the nine selected elastomeric material models (Neo-Hookean, Mooney with two and three constants, Signorini, Yeoh, Ogden, Arruda-Boyce, Gent and Marlow), which the material constants were determined in one material test - the uniaxial tension testing. The convergence assessment of nine analyzed models were made on the basis of their performance from an experimental bending test of the elastomer samples from the results of numerical calculations FEM for each material models. To calculate the material constants for the analyzed materials, a model has been generated by the stressstrain characteristics created as a result of experimental uniaxial tensile test with elastomeric dumbbell samples, taking into account the parameters received in its 18th cycle. Using such a calculated material constants numerical simulation of the bending process of a elastomeric, parallelepipedic sampleswere carried out using MARC / Mentat program.

Sexuality among 7th, 8th and 9th grade students in the state of Lara, Venezuela. The Global School Health Survey, 2003-2004.

PubMed

Granero, Ricardo; Poni, Esteban S; Sánchez, Zoraida

2007-09-01

Effective sexual health promotion programs need to be based on evidence; this study describes a set of sexual behavioral patterns, education and other subjects related to sexual life among 71th, 8th and 9th grade students in the State of Lara, Venezuela. During 2003 to 2004 school period, 2070 students filled out the Global School Health Survey (GSHS)--a school based cross-sectional self-administered survey that explores, among other areas, sexual behavior. Students who responded that ever had intercourse, males 27% and females 3.8%; by grade, males 18.2% (7th) and 37.6 % (9th), and females 1.9% (7th) and 6.2% (9th). The group who had intercourse, 54.9% males and 25.3% females had it by age 12; 59% males and 78.6% females were sexually active in the past 12 months; 59.2% males and 43.2% females used condom in the last intercourse; and 48.3% males and 21.5% females has 2 or more sexual partners in their life. A disparity is present in school-based information, >63% for AIDS and <32% for sexual abuse. This study shows that a substantial number of students had sexual intercourse initiation at early age (<12), history of multiple sexual partners and low prevalence of condom use. An unbalanced coverage of information on AIDS and sexual abuse is highly prevalent in the school. However, the implementation and evaluation of comprehensive programs on healthy sexual life must take into account that still a majority of students report abstinence from sexual intercourse.

Glial cell line-derived neurotrophic factor promotes the development of adrenergic neurons in mouse neural crest cultures

PubMed Central

Maxwell, Gerald D.; Reid, Kate; Elefanty, Andrew; Bartlett, Perry F.; Murphy, Mark

1996-01-01

Growth of mouse neural crest cultures in the presence of glial cell line-derived neurotrophic factor (GDNF) resulted in a dramatic dose-dependent increase in the number of tyrosine hydroxylase (TH)-positive cells that developed when 5% chicken embryo extract was present in the medium. In contrast, growth in the presence of bone morphogenetic protein (BMP)-2, BMP-4, BMP-6, transforming growth factor (TGF) β1, TGF-β2, and TGF-β3 elicited no increase in the number of TH-positive cells. The TH-positive cells that developed in the presence of GDNF had neuronal morphology and contained the middle and low molecular weight neurofilament proteins. Numerous TH-negative cells with the morphology of neurons also were observed in GDNF-treated cultures. Analysis revealed that the period from 6 to 12 days in vitro was the critical time for exposure to GDNF to generate the increase in TH-positive cell number. The growth factors neurotrophin-3 and fibroblast growth factor-2 elicited increases in the number of TH-positive cells similar to that seen in response to GDNF. In contrast, nerve growth factor was unable to substitute for GDNF. These findings extend the previously reported biological activities of GDNF by showing that it can act on mouse neural crest cultures to promote the development of neurons. PMID:8917581

TH-9 (a theophylline derivative) induces long-lasting enhancement in excitatory synaptic transmission in the rat hippocampus that is occluded by frequency-dependent plasticity in vitro.

PubMed

Nashawi, H; Bartl, T; Bartl, P; Novotny, L; Oriowo, M A; Kombian, S B

2012-09-18

Dementia, especially Alzheimer's disease, is a rapidly increasing medical condition that presents with enormous challenge for treatment. It is characterized by impairment in memory and cognitive function often accompanied by changes in synaptic transmission and plasticity in relevant brain regions such as the hippocampus. We recently synthesized TH-9, a conjugate racetam-methylxanthine compound and tested if it had potential for enhancing synaptic function and possibly, plasticity, by examining its effect on hippocampal fast excitatory synaptic transmission and plasticity. Field excitatory postsynaptic potentials (fEPSPs) were recorded in the CA1 hippocampal area of naïve juvenile male Sprague-Dawley rats using conventional electrophysiological recording techniques. TH-9 caused a concentration-dependent, long-lasting enhancement in fEPSPs. This effect was blocked by adenosine A1, acetylcholine (muscarinic and nicotinic) and glutamate (N-methyl-d-aspartate) receptor antagonists but not by a γ-aminobutyric acid receptor type B (GABA(B)) receptor antagonist. The TH-9 effect was also blocked by enhancing intracellular cyclic adenosine monophosphate and inhibiting protein kinase A. Pretreatment with TH-9 did not prevent the induction of long-term potentiation (LTP) or long-term depression (LTD). Conversely, induction of LTP or LTD completely occluded the ability of TH-9 to enhance fEPSPs. Thus, TH-9 utilizes cholinergic and adenosinergic mechanisms to cause long-lasting enhancement in fEPSPs which were occluded by LTP and LTD. TH-9 may therefore employ similar or convergent mechanisms with frequency-dependent synaptic plasticities to produce the observed long-lasting enhancement in synaptic transmission and may thus, have potential for use in improving memory. Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

Prevalence of obesity among youths in Mississippi: United States, 1999-2015.

PubMed

Aranmolate, Rasaki

2017-11-23

Background The prevalence of obesity among youths has become a public health problem. The trend in the prevalence of obesity among high school students in Mississippi has not been examined in the last 17 years. Methods The data from the Mississippi High School Youth Risk Behavior Survey from 1999 to 2015 were used to determine the prevalence of obesity. The definition of obesity was based on age- and sex-specific body mass index (BMI) of more than 95th percentile, according to 2000 Centers for Disease Control and Prevention (CDC) growth charts. The differences in the groups were examined using the univariate t-test statistical analysis at p < 0.05 and frequency distribution to determine the percentage differences. Results There was a decline in the prevalence of obesity from 1999 to 2015 among Whites but no significant decrease among Blacks. The prevalence based on race in 2105 was 18.9%, which is higher than 14.4% in 1999 and remaining years. The rate of obesity based on race and sex was 27.7% among Blacks and 15.9% among White males in 2015. The Black females had prevalence of 20.6%, which is higher than their White counterpart (12.1%) in 2015 and previous years. Conclusion The prevalence of obesity among Blacks was higher when compared to White students. There was an increased prevalence of obesity in males over females. Students in 9th and 10th grade had a higher prevalence of obesity than those in 11th and 12th grade.

Waist circumference distribution in Colombian schoolchildren and adolescents: The FUPRECOL Study.

PubMed

Caicedo-Álvarez, Juan Carlos; Correa-Bautista, Jorge Enrique; González-Jiménez, Emilio; Schmidt-RioValle, Jacqueline; Ramírez-Vélez, Robinson

2016-01-01

This study was intended to establish the percentile distribution of waist circumference in schoolchildren from Bogota, Colombia, participating in the FUPRECOL Study. A cross-sectional study conducted in 3,005 children and 2,916 adolescents aged 9 to 17.9 years. Height, weight, waist circumference, hip circumference, and self-assessed sexual maturity status were recorded. Percentiles (3(rd), 10(th), 25(th), 50(th), 75(th), 90(th), and 97(th)) and smoothed sex- and age-specific curves were calculated, and the waist circumference values found were compared to international references from other ethnic populations. Fifty-seven percent of the overall population (n=5,921) were females (mean age, 12.7±2.3 years). In most age groups, waist circumference was greater in boys as compared to girls. The increase between the 50(th) and 97(th) percentiles by age was 15.7cm in boys aged 9 to 9.9 years and 16.0cm in girls aged 11-11.9 years. Comparison of our study results, by age group and sex, to international references showed that our 50(th) percentile was lower than reported in Peru and the UK except for studies in India, Venezuela (Merida), US, and Spain was higher. Age- and sex-specific percentiles of waist circumference obtained from children and adolescents from Bogota, Colombia, are reported. They may be used as a reference both for nutritional assessment and for predicting cardiovascular risks at early ages. Copyright © 2016 SEEN. Published by Elsevier España, S.L.U. All rights reserved.

A brief history of numbers and statistics with cytometric applications.

PubMed

Watson, J V

2001-02-15

A brief history of numbers and statistics traces the development of numbers from prehistory to completion of our current system of numeration with the introduction of the decimal fraction by Viete, Stevin, Burgi, and Galileo at the turn of the 16th century. This was followed by the development of what we now know as probability theory by Pascal, Fermat, and Huygens in the mid-17th century which arose in connection with questions in gambling with dice and can be regarded as the origin of statistics. The three main probability distributions on which statistics depend were introduced and/or formalized between the mid-17th and early 19th centuries: the binomial distribution by Pascal; the normal distribution by de Moivre, Gauss, and Laplace, and the Poisson distribution by Poisson. The formal discipline of statistics commenced with the works of Pearson, Yule, and Gosset at the turn of the 19th century when the first statistical tests were introduced. Elementary descriptions of the statistical tests most likely to be used in conjunction with cytometric data are given and it is shown how these can be applied to the analysis of difficult immunofluorescence distributions when there is overlap between the labeled and unlabeled cell populations. Copyright 2001 Wiley-Liss, Inc.

Summer Transportation Institute 2001

DOT National Transportation Integrated Search

2002-04-03

The residential STI program was held at Lincoln University during July 9 - August 3, 2001. Twenty students (nine 8th graders, 9th graders, and four 10th graders) participated in the program. One student was advised to withdrawal after two weeks. The ...

Developmental Thyroid Hormone Disruption: Prevalence, Environmental Contaminants and Neurodevelopmental Consequences

EPA Science Inventory

Thyroid hormones (TH) are critical for growth and development and particularly brain development. There are numerous environmental agents that lead to marginal reductions of circulating TH. Although it is clear that severe developmental hypothyroidism is profoundly detrimental to...

A hospital-based birth weight analysis using computerized perinatal data base for a Chinese population.

PubMed

Fu, Jing; Yu, Mei

2011-04-01

We aimed to construct birth weight-for-gestational age nomograms based on a computerized perinatal data base in a hospital-based Chinese population. Retrospectively collected 28,052 singleton deliveries at Women and Children's Medical Center, Guangzhou, China. Standard curves of birth weight from 27 to 43 week's gestation were computed. The nomograms included the 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles and standard deviations. 79.9% pregnant women delivered between 38, 39, and 40 gestational week, and the mean birth weights are 3160, 3282, and 3388 g, respectively. Preterm birth is 5.7%. In general, male birth weights are greater than females at each gestational week. The hospital-based Chinese population birth weight is lower than that of North American and Scandinavian population. A different standard birth weight is needed for different population. A hospital-based birth weight curve by gestational week is established, which can be a useful tool to estimate intrauterine fetal growth to define SGA or LGA fetuses.

Analysis of the effect of CPP-ACP tooth mousse on enamel remineralization by circularly polarized images.

PubMed

Wu, Guotao; Liu, Xinqiang; Hou, Yongfu

2010-09-01

To evaluate the effect of casein phosphopeptide-amorphous calcium phosphate tooth mousse on the remineralization of bovine incisor by circularly polarized images. Eighty bovine incisors, each with a 4 x 4 mm artificially demineralized area, were used. The samples were divided into four groups: Group A, casein phosphopeptide-amorphous calcium phosphate tooth mousse; Group B, fluoride toothpaste; Group C, casein phosphopeptide-amorphous calcium phosphate tooth mousse and fluoride toothpaste; and Group D, no treatment. Circularly polarized images were taken after the specimens were treated for 3, 6, 9, or 12 weeks, and the size of the demineralized area and the mean grey level were measured. Data analysis was done using repeated measures variance analysis. Pearson correlation coefficients were computed to evaluate the correlation between the size of the demineralized area and the mean grey level. In all four groups, the size of the demineralized area and the mean grey level declined with time. The size of the demineralized area of Group C was significantly smaller than that of Group A at the end of the third and sixth weeks (P = .039, P = .000, respectively), and the mean grey level of Group C was lower than that of Group A at the end of the 6th and 12th weeks (P = .037, P = .004, respectively). At the end of the 6th, 9th, and 12th weeks, the size of the demineralized area of Group C was smaller (P = .000, P = .005, P = .005, respectively) and the mean grey level was lower (P = .000) than those of Group B. No statistically significant correlations were detected between the size of the demineralized area and the mean grey level. Casein phosphopeptide-amorphous calcium phosphate tooth mousse can reduce the size and mean grey level of demineralized areas and promote the remineralization of bovine enamel. Combined application with fluoride toothpaste strengthens the effect.

Impact of developmental lead exposure on splenic factors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kasten-Jolly, Jane, E-mail: kjolly@wadsworth.or; Heo, Yong, E-mail: yheo@cu.ac.k; Lawrence, David A., E-mail: david.lawrence@wadsworth.or

2010-09-01

Lead (Pb) is known to alter the functions of numerous organ systems, including the hematopoietic and immune systems. Pb can induce anemia and can lower host resistance to bacterial and viral infections. The anemia is due to Pb's inhibition of hemoglobin synthesis and Pb's induction of membrane changes, leading to early erythrocyte senescence. Pb also increases B-cell activation/proliferation and skews T-cell help (Th) toward Th2 subset generation. The specific mechanisms for many of the Pb effects are, as yet, not completely understood. Therefore, we performed gene expression analysis, via microarray, on RNA from the spleens of developmentally Pb-exposed mice, inmore » order to gain further insight into these Pb effects. Splenic RNA microarray analysis indicated strong up-regulation of genes coding for proteolytic enzymes, lipases, amylase, and RNaseA. The data also showed that Pb affected the expression of many genes associated with innate immunity. Analysis of the microarray results via GeneSifter software indicated that Pb increased apoptosis, B-cell differentiation, and Th2 development. Direct up-regulation by Pb of expression of the gene encoding the heme-regulated inhibitor (HRI) suggested that Pb can decrease erythropoiesis by blocking globin mRNA translation. Pb's high elevation of digestive/catabolizing enzymes could generate immunogenic self peptides. With Pb's potential to induce new self-peptides and to enhance the expression of caspases, cytokines, and other immunomodulators, further evaluation of Pb's involvement in autoimmune phenomena, especially Th2-mediated autoantibody production, and alteration of organ system activities is warranted.« less

Identification or Development of Chemical Analysis Methods for Plants and Animal Tissues

DTIC Science & Technology

1981-01-01

Report No. DRXTH-TE-CR-80086 [E EMWSTEEACISITE - IDENTIFICATION OR DEVELOPMENT OF CHEMICAL ANALYSISI METHODS FOR PLANTS AND ANIMAL TISSUES D l...86i 4TITLE (ansdo"t) TYPE or" P 4. Iih~iti.)Final epwt. )9 A4,417 ~, Identlifiation or Development of Chemical I-g 9 O d 18 Analysis Methods for Plants...n TN oT sacmpihdo in. wEr DContinng er adetcsr aid Iuent bybopkmertda lo aeo 1.5th 1/s deeipta24ndectr Tritrotasolsoepae d andT Boloia Matrc,, 1473

Is the USAF Officer Corps a Fighting Force?

DTIC Science & Technology

1988-05-01

quottin)j analysis, and operational audit . Following work moasurent and 14 computAtions, th., standards 4uro staffed and approved by NQ USAF *rnl...occupation group in the Air Force. 9 Most recently# Senator John Glenn has asked the GAO to conduct an audit of pilot requirements.1 9 This information...AlIocdtion System," Air Force Times, 14 September 1987, p. 6. 9. Pat )alton, " Audit Pilot Requirements, Glenn Asks GAO," Air Forte Times, 18 January 1988

9th International Conference on Multiphase Flow (ICMF 2016)

DTIC Science & Technology

2016-08-12

Office of Naval Research Global (ONRG) Final CSP (Collaborative Science Program) Report Administrative Details: Event Name: 9th ...International Conference on Multiphase Flows Event Dates: May 22-27, 2016 Event City and Country: Florence, Italy Grantee (Name and Contact...2043 Date of the Final Report: August 12, 2016 Abstract: This report summarizes the main activities and outcomes of the 9th International

Aiming Higher: Is Your 9th Grader on Track for College?

ERIC Educational Resources Information Center

New Visions for Public Schools, 2008

2008-01-01

A teenager's future starts on 9th grade with the safe and welcoming environment, excellent teachers, and challenging instruction provided at this school. Believe it or not, college begins in 9th grade. If parents dream of their son or daughter going to college, they should not put off planning until their junior or senior year in high school--it…

Collisional dark matter and the origin of massive black holes

PubMed

Ostriker

2000-06-05

If the cosmological dark matter is primarily in the form of an elementary particle which has mass m(p) and cross section for self-interaction sigma, then seed black holes (formed in stellar collapse) will grow in a Hubble time t(H) due to accretion of the dark matter to a mass, M(H) = sqrt[IC(9)(A)t(H)(sigma/G(3)m(p)c(2))] = 7.1x10(6)(sigma/m(p))(1/2)V(9/2)(c)t(1/2)(H,15) solar masses. Here I is a numerical factor, C(A) the galactic velocity dispersion, and V(c) its rotation velocity. For the same values of ( sigma/m(p)) that are attractive with respect to other cosmological desiderata, this produces massive black holes in the (10(6)-10(9))M( middle dot in circle) range observed, with the same dependence on a V(c) seen, and with a time dependence consistent with observations. Other astrophysical consequences of collisional dark matter and tests of the idea are noted.

Standard outcome indicators after colon cancer resection. Creation of a nomogram for autoevaluation.

PubMed

Sancho-Muriel, Jorge; Frasson, Matteo; Hervás, David; Flor-Lorente, Blas; Ramos Rodriguez, José Luis; Romero Simó, Manuel; Escoll Rufino, Jordi; Santamaría Olabarrieta, Marta; Viñas Martinez, José; López Bañeres, Manolo; García-Granero, Eduardo

2017-01-01

Lately there has been an increasing interest in identifying quality standards in different pathologies, among them colon cancer due to its great prevalence. The main goal of this study is to define the quality standards of colon cancer surgery based on a large prospective national study dataset. Data from the prospective national study ANACO were used. This study included a consecutive series of patients operated on for colon cancer in 52 Spanish hospitals (2011-2012). Centers with less than 30 patients were excluded. The present analysis finally included 42 centers (2975 patients). Based on the results obtained in 4main indicators from each hospital (anastomotic leak, lymph-nodes found in the specimen, mortality and length of stay), a nomogram that allows the evaluation of the performance of each center was designed. Standard results for further 5 intraoperative and 5 postoperative quality indicators were also reported. Median of anastomotic leak and mortality rate was 8.5% (25 th -75 th percentiles 6.1%-12.4%) and 2.5% (25 th -75 th percentiles 0.6%-4.7%), respectively. Median number of nodes found in the surgical specimen was 15,1 (25 th -75 th percentiles 18-14 nodes). Median length of postoperative stay was 7.7 days (25 th -75 th percentiles 6.9-9.2 days). Based on these data, a nomogram for hospital audit was created. Standard surgical results after colon cancer surgery were defined, creating a tool for auto-evaluation and allowing each center to identify areas for improvement in the surgical treatment of colon cancer. Copyright © 2016 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

History of Binary and Other Nondecimal Numeration.

ERIC Educational Resources Information Center

Glaser, Anton

This study traces the development of nondecimal numeration from the 16th century to the present. The first six chapters detail the contributions of mathematicians as well as people from other fields. Applications to computers are covered in one chapter, while another chapter discusses the coverage of numeration systems in college textbooks for…

Children with mathematical learning disability fail in recruiting verbal and numerical brain regions when solving simple multiplication problems.

PubMed

Berteletti, Ilaria; Prado, Jérôme; Booth, James R

2014-08-01

Greater skill in solving single-digit multiplication problems requires a progressive shift from a reliance on numerical to verbal mechanisms over development. Children with mathematical learning disability (MD), however, are thought to suffer from a specific impairment in numerical mechanisms. Here we tested the hypothesis that this impairment might prevent MD children from transitioning toward verbal mechanisms when solving single-digit multiplication problems. Brain activations during multiplication problems were compared in MD and typically developing (TD) children (3rd to 7th graders) in numerical and verbal regions which were individuated by independent localizer tasks. We used small (e.g., 2 × 3) and large (e.g., 7 × 9) problems as these problems likely differ in their reliance on verbal versus numerical mechanisms. Results indicate that MD children have reduced activations in both the verbal (i.e., left inferior frontal gyrus and left middle temporal to superior temporal gyri) and the numerical (i.e., right superior parietal lobule including intra-parietal sulcus) regions suggesting that both mechanisms are impaired. Moreover, the only reliable activation observed for MD children was in the numerical region when solving small problems. This suggests that MD children could effectively engage numerical mechanisms only for the easier problems. Conversely, TD children showed a modulation of activation with problem size in the verbal regions. This suggests that TD children were effectively engaging verbal mechanisms for the easier problems. Moreover, TD children with better language skills were more effective at engaging verbal mechanisms. In conclusion, results suggest that the numerical- and language-related processes involved in solving multiplication problems are impaired in MD children. Published by Elsevier Ltd.

Summer Transportation Institute 2001

DOT National Transportation Integrated Search

2002-04-01

The residential STI program was held at Lincoln University during July 9-August 3, 2001. Twenty students (nine 8th graders, 9th graders, and four 10th graders) participated in the program. One student was advised to withdraw after two weeks. The stud...

75 FR 70363 - Citizens Coinage Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-17

.... Time: 8 a.m. to 12 p.m. Location: 8th Floor Board Room, United States Mint, 801 9th Street, NW... CONTACT: Cliff Northup, United States Mint Liaison to the CCAC; 801 9th Street, NW., Washington, DC 20220...

Ground Deformation and Sources geometry of the 2016 Central Italy Earthquake Sequence Investigated through Analytical and Numerical Modeling of DInSAR Measurements and Structural-Geological Data

NASA Astrophysics Data System (ADS)

Solaro, G.; Bonano, M.; Boncio, P.; Brozzetti, F.; Castaldo, R.; Casu, F.; Cirillo, D.; Cheloni, D.; De Luca, C.; De Nardis, R.; De Novellis, V.; Ferrarini, F.; Lanari, R.; Lavecchia, G.; Manunta, M.; Manzo, M.; Pepe, A.; Pepe, S.; Tizzani, P.; Zinno, I.

2017-12-01

The 2016 Central Italy seismic sequence started on 24th August with a MW 6.1 event, where the intra-Apennine WSW-dipping Vettore-Gorzano extensional fault system released a destructive earthquake, causing 300 casualties and extensive damage to the town of Amatrice and surroundings. We generated several interferograms by using ALOS and Sentinel 1-A and B constellation data acquired on both ascending and descending orbits to show that most displacement is characterized by two main subsiding lobes of about 20 cm on the fault hanging-wall. By inverting the generated interferograms, following the Okada analytical approach, the modelling results account for two sources related to main shock and more energetic aftershock. Through Finite Element numerical modelling that jointly exploits DInSAR deformation measurements and structural-geological data, we reconstruct the 3D source of the Amatrice 2016 normal fault earthquake which well fit the main shock. The inversion shows that the co-seismic displacement area was partitioned on two distinct en echelon fault planes, which at the main event hypocentral depth (8 km) merge in one single WSW-dipping surface. Slip peaks were higher along the southern half of the Vettore fault, lower along the northern half of Gorzano fault and null in the relay zone between the two faults; field evidence of co-seismic surface rupture are coherent with the reconstructed scenario. The following seismic sequence was characterized by numerous aftershocks located southeast and northwest of the epicenter which decreased in frequency and magnitude until the end of October, when a MW 5.9 event occurred on 26th October about 25 km to the NW of the previous mainshock. Then, on 30th October, a third large event of magnitude MW 6.5 nucleated below the town of Norcia, striking the area between the two preceding events and filling the gap between the previous ruptures. Also in this case, we exploit a large dataset of DInSAR and GPS measurements to investigate the ground displacement field and to determine, by using elastic dislocation modelling, the geometries and slip distributions of the causative normal fault segments.

Determination of the Ephemeris Accuracy for AJISAI, LAGEOS and ETALON Satellites, Obtained with A Simplified Numerical Motion Model Using the ILRS Coordinates

NASA Astrophysics Data System (ADS)

Kara, I. V.

This paper describes a simplified numerical model of passive artificial Earth satellite (AES) motion. The model accuracy is determined using the International Laser Ranging Service (ILRS) highprecision coordinates. Those data are freely available on http://ilrs.gsfc.nasa.gov. The differential equations of the AES motion are solved by the Everhart numerical method of 17th and 19th orders with the integration step automatic correction. The comparison between the AES coordinates computed with the motion model and the ILRS coordinates enabled to determine the accuracy of the ephemerides obtained. As a result, the discrepancy of the computed Etalon-1 ephemerides from the ILRS data is about 10'' for a one-year ephemeris.

Requirements and Their Impact Downstream: Improving Casual Analysis Processes Through Measurement and Analysis of Textual Information

DTIC Science & Technology

2008-09-01

re-considered for future use in the PCRs. Its reintroduction should be accompanied with more adequate support for selecting appropriate quality...cnr.it/Papers/ODBASE- CONTEXT.pdf. [Goethert 2007] Goethert, Wolf & Goldenson, Dennis. "Implementing CMMI® Measurement & Analysis Using Goal-Driven...9th Annual Practical Software and Systems Measurement Users’ Group Conference. Keystone, Colorado , July 2005. [Monarch 1995] Ira A. Monarch. An

Listeria arpJ gene modifies T helper type 2 subset differentiation.

PubMed

Kanoh, Makoto; Maruyama, Saho; Shen, Hua; Matsumoto, Akira; Shinomiya, Hiroto; Przybilla, Karin; Gouin, Edith; Cossart, Pascale; Goebel, Werner; Asano, Yoshihiro

2015-07-15

Although the T-cell subset differentiation pathway has been characterized extensively from the view of host gene regulation, the effects of genes of the pathogen on T-cell subset differentiation during infection have yet to be elucidated. Especially, the bacterial genes that are responsible for this shift have not yet been determined. Utilizing a single-gene-mutation Listeria panel, we investigated genes involved in the host-pathogen interaction that are required for the initiation of T-cell subset differentiation in the early phase of pathogen infection. We demonstrate that the induction of T helper types 1 and 2 (Th1 and Th2) subsets are separate phenomena and are mediated by distinct Listeria genes. We identified several candidate Listeria genes that appear to be involved in the host-Listeria interaction. Among them, arpJ is the strongest candidate gene for inhibiting Th2 subset induction. Furthermore, the analysis utilizing arpJ-deficient Listeria monocytogenes (Lm) revealed that the tumor necrosis factor (TNF) superfamily (Tnfsf) 9-TNF receptor superfamily (Tnfrsf) 9 interaction inhibits the Th2 response during Lm infection. arpJ is the candidate gene for inhibiting Th2 T-cell subset induction. The arpJ gene product influences the expression of Tnfsf/Tnfrsf on antigen-presenting cells and inhibits the Th2 T-cell subset differentiation during Listeria infection. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Logo for the 20th Anniversary of the Apollo 11 mission

NASA Technical Reports Server (NTRS)

1989-01-01

Logo for the 20th Anniversary of the Apollo 11 mission. Logo is described as the numeral 20. Inside the zero is a representation of an eagle landing on the lunar surface with the title 'Apollo 11' above it.

Logo for the 20th Anniversary of the Apollo 11 mission

NASA Image and Video Library

1989-02-06

Logo for the 20th Anniversary of the Apollo 11 mission. Logo is described as the numeral 20. Inside the zero is a representation of an eagle landing on the lunar surface with the title "Apollo 11" above it.

Socio-Economic, Demographic and Lifestyle Determinants of Overweight and Obesity among Adults of Northeast India.

PubMed

Rengma, Melody Seb; Sen, Jaydip; Mondal, Nitish

2015-07-01

Overweight and obesity are the accumulation of high body adiposity, which can have detrimental health effects and contribute to the development of numerous preventable non-communicable diseases. This study aims to evaluate the effect of socio-economic, demographic and lifestyle factors on the prevalence of overweight and obesity among adults belonging to the Rengma-Naga population of North-east India. This cross-sectional study was conducted among 826 Rengma-Naga individuals (males: 422; females: 404) aged 20-49 years from the Karbi Anglong District of Assam, using a two-stage stratified random sampling. The socio-economic, demographic and lifestyle variables were recorded using structured schedules. Height and weight were recorded and the Body Mass Index (BMI) was calculated using standard procedures and equation. The WHO (2000) cut-off points were utilized to assess the prevalence of overweight (BMI ≥23.00-24.99 kg/m(2)) and obesity (BMI ≥25.00 kg/m(2)). The data were analysed using ANOVA, chi-square analysis and binary logistic regression analysis using SPSS (version 17.0). The prevalence of overweight and obesity were 32.57% (males: 39.34%; females: 25.50%) and 10.77% (males: 9.95%; females: 11.63%), respectively. The binary logistic regression analysis showed that age groups (e.g., 40-49 years), education (≥9(th) standard), part-time occupation and monthly income (≥Rs.10000) were significantly associated with overweight and obesity (p<0.05). Age, education occupation and income appear to have higher associations with overweight and obesity among adults. Suitable healthcare strategies and intervention programmes are needed for combating such prevalence in population.

Geotechnical Feasibility Analysis of Compressed Air Energy Storage (CAES) in Bedded Salt Formations: a Case Study in Huai'an City, China

NASA Astrophysics Data System (ADS)

Zhang, Guimin; Li, Yinping; Daemen, Jaak J. K.; Yang, Chunhe; Wu, Yu; Zhang, Kai; Chen, Yanlong

2015-09-01

The lower reaches of the Yangtze River is one of the most developed regions in China. It is desirable to build compressed air energy storage (CAES) power plants in this area to ensure the safety, stability, and economic operation of the power network. Geotechnical feasibility analysis was carried out for CAES in impure bedded salt formations in Huai'an City, China, located in this region. First, geological investigation revealed that the salt groups in the Zhangxing Block meet the basic geological conditions for CAES storage, even though the possible unfavorable characteristics of the salt formations include bedding and different percentages of impurities. Second, mechanical tests were carried out to determine the mechanical characteristics of the bedded salt formations. It is encouraging that the samples did not fail even when they had undergone large creep deformation. Finally, numerical simulation was performed to evaluate the stability and volume shrinkage of the CAES under the following conditions: the shape of a single cavern is that of a pear; the width of the pillar is adopted as two times the largest diameter; three regular operating patterns were adopted for two operating caverns (internal pressure 9-10.5 MPa, 10-11.5 MPa, and 11-12.5 MPa), while the other two were kept at high pressure (internal pressure 10.5, 11.5, and 12.5 MPa) as backups; an emergency operating pattern in which two operating caverns were kept at atmospheric pressure (0.1 MPa) for emergency while the backups were under operation (9-10.5 MPa), simulated for 12 months at the beginning of the 5th year. The results of the analysis for the plastic zone, displacement, and volume shrinkage support the feasibility of the construction of an underground CAES power station.

Teacher's Classroom Management Behavior and Students' Classroom Misbehavior: A Study with 5th through 9th-Grade Students

ERIC Educational Resources Information Center

Lopes, João; Silva, Elisabete; Oliveira, Célia; Sass, Daniel; Martin, Nancy

2017-01-01

Introduction: Classroom misbehavior is a major source of classroom-wasted time and a situation that negatively interferes with students' opportunity to learn. Method: The present study investigated the relation between 5th through 9th grade perceived Portuguese teacher's classroom management, teacher's perceived time spend with misbehavior,…

Material Development and Meeting Learner's Need

ERIC Educational Resources Information Center

Aydin, Abdullah

2013-01-01

In this study, the aim was to show that learners' needs can be met using simple and cheap materials that can be found everywhere in 9th to 11th grade Chemistry courses. To this end, materials were developed using simple everyday life materials for 9th to 11th grade Chemistry courses. In the research, the project method was employed. The study was…

Anti-inflammatory effects of interleukin-23 receptor cytokine-binding homology region rebalance T cell distribution in rodent collagen-induced arthritis

PubMed Central

Guo, Wei; Yu, Dongmei; Wang, Xin; Luo, Cheng; Chen, Yucong; Lei, Wen; Wang, Chen; Ge, Yaoyao; Xue, Wenyao; Tian, Qiqi; Gao, Xiangdong; Yao, Wenbing

2016-01-01

IL-23 is an important cytokine to regulate Th17 cell differentiation and promote the proliferation of inflammatory cells in Th17-mediated autoimmune diseases. The collagen-induced arthritis (CIA) in rat is a model of rheumatoid arthritis characterized by pronounced inflammatory auto-responses from B and T cells, especially Th17 cells in lesions. In the present study, we used rhIL23R-CHR to block the IL-23 signaling pathway to probe the importance of IL-23 in misbalancing the ratio of Th17/Th9/Treg cells in CIA rats. After treatments with rhIL23R-CHR, the CIA rats showed a significant decrease of secretions of IL-17 and IL-9, whereas FoxP3 was activated in the process, indicating that IL-23 can manipulate the balance of Th17/Th9/Treg cells. Similar to the animal model, IL-23 also possessed remarkable proinflammatory effects on human fibroblast-like synoviocyte cells (HFLS), showing synergetic outcomes with TNF-α. Together, IL-23 could act as a modulator to imbalance the ratio of Th17/Th9/Treg cells, and rhIL23R-CHR could serve as a potential therapeutic agent for RA patients. PMID:27177334

Comparative Analysis of Cellular Immune Responses in Treated Leishmania Patients and Hamsters against Recombinant Th1 Stimulatory Proteins of Leishmania donovani

PubMed Central

Joshi, Sumit; Yadav, Narendra K.; Rawat, Keerti; Tripathi, Chandra Dev P.; Jaiswal, Anil K.; Khare, Prashant; Tandon, Rati; Baharia, Rajendra K.; Das, Sanchita; Gupta, Reema; Kushawaha, Pramod K.; Sundar, Shyam; Sahasrabuddhe, Amogh A.; Dube, Anuradha

2016-01-01

Our prior studies demonstrated that cellular response of T helper 1 (Th1) type was generated by a soluble antigenic fraction (ranging from 89.9 to 97.1 kDa) of Leishmania donovani promastigote, in treated Leishmania patients as well as hamsters and showed significant prophylactic potential against experimental visceral leishmaniasis (VL). Eighteen Th1 stimulatory proteins were identified through proteomic analysis of this subfraction, out of which 15 were developed as recombinant proteins. In the present work, we have evaluated these 15 recombinant proteins simultaneously for their comparative cellular responses in treated Leishmania patients and hamsters. Six proteins viz. elongation factor-2, enolase, aldolase, triose phosphate isomerase, protein disulfide isomerase, and p45 emerged as most immunogenic as they produced a significant lymphoproliferative response, nitric oxide generation and Th1 cytokine response in PBMCs and lymphocytes of treated Leishmania patients and hamsters respectively. The results suggested that these proteins may be exploited for developing a successful poly-protein and/or poly-epitope vaccine against VL. PMID:27047452

Modulation of CD4+ and CD8+ T Cell Function and Cytokine Responses in Strongyloides stercoralis Infection by Interleukin-27 (IL-27) and IL-37.

PubMed

Anuradha, Rajamanickam; Munisankar, Saravanan; Bhootra, Yukthi; Dolla, Chandrakumar; Kumaran, Paul; Nutman, Thomas B; Babu, Subash

2017-11-01

Strongyloides stercoralis infection is associated with diminished antigen-specific Th1- and Th17-associated responses and enhanced Th2-associated responses. Interleukin-27 (IL-27) and IL-37 are two known anti-inflammatory cytokines that are highly expressed in S. stercoralis infection. We therefore wanted to examine the role of IL-27 and IL-37 in regulating CD4 + and CD8 + T cell responses in S. stercoralis infection. To this end, we examined the frequency of Th1/Tc1, Th2/Tc2, Th9/Tc9, Th17/Tc17, and Th22/Tc22 cells in 15 S. stercoralis -infected individuals and 10 uninfected individuals stimulated with parasite antigen following IL-27 or IL-37 neutralization. We also examined the production of prototypical type 1, type 2, type 9, type 17, and type 22 cytokines in the whole-blood supernatants. Our data reveal that IL-27 or IL-37 neutralization resulted in significantly enhanced frequencies of Th1/Tc1, Th2/Tc2, Th17/Tc17, Th9, and Th22 cells with parasite antigen stimulation. There was no induction of any T cell response in uninfected individuals following parasite antigen stimulation and IL-27 or IL-37 neutralization. Moreover, we also observed increased production of gamma interferon (IFN-γ), IL-5, IL-9, IL-17, and IL-22 and decreased production of IL-10 following IL-27 and IL-37 neutralization and parasite antigen stimulation in whole-blood cultures. Thus, we demonstrate that IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection. Copyright © 2017 American Society for Microbiology.

An Evaluation of the Air-to-Air Engagement Models in the Naval Warfare Gaming System.

DTIC Science & Technology

1984-03-01

documentaticr 9valuation phase andI ths =acomera-aticns Phasr?. During tzhe descri-ption ph as e, a closs examira-tion and analysi-s of the : cutines and...modelin asoacts ,Of the = cutines . In this appendix, most o f thIe- alimizis rativs- programming isbypassed. In Appendix B, the 23 Mod-? _1ira nIs ocr

A Content Analysis of the WH-Questions in the EFL Textbook of "Horizons"

ERIC Educational Resources Information Center

Igbaria, Abdul Kareem

2013-01-01

This study dealt with analysis of the study units in the textbook "Horizons" for 9th-grade students studying English in mixed ability classes. The study sought to examine the variety in the cognitive level represented by the WH-questions in the textbook according to Bloom's taxonomy. The study also attempted to examine the extent in…

75 FR 11228 - Citizens Coinage Advisory Committee March 2010 Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

..., 2010. Time: 3 p.m. to 5 p.m. Location: 8th Floor Boardroom, United States Mint, 801 9th Street, NW... CONTACT: Cliff Northup, United States Mint Liaison to the CCAC; 801 9th Street, NW.; Washington, DC 20220...

Advanced Methods for Aircraft Engine Thrust and Noise Benefits: Nozzle-Inlet Flow Analysis

NASA Technical Reports Server (NTRS)

Gilinsky, Mikhail; Morgan, Morris H.; Povitsky, Alex; Schkolnikov, Natalia; Njoroge, Norman; Coston, Calvin; Blankson, Isaiah M.

2001-01-01

The Fluid Mechanics and Acoustics Laboratory at Hampton University (HU/FM&AL) jointly with the NASA Glenn Research Center has conducted four connected subprojects under the reporting project. Basically, the HU/FM&AL Team has been involved in joint research with the purpose of theoretical explanation of experimental facts and creation of accurate numerical simulation techniques and prediction theory for solution of current problems in propulsion systems of interest to the NAVY and NASA agencies. This work is also supported by joint research between the NASA GRC and the Institute of Mechanics at Moscow State University (IM/MSU) in Russia under a CRDF grant. The research is focused on a wide regime of problems in the propulsion field as well as in experimental testing and theoretical and numerical simulation analyses for advanced aircraft and rocket engines. The FM&AL Team uses analytical methods, numerical simulations and possible experimental tests at the Hampton University campus. The fundamental idea uniting these subprojects is to use nontraditional 3D corrugated and composite nozzle and inlet designs and additional methods for exhaust jet noise reduction without essential thrust loss and even with thrust augmentation. These subprojects are: (1) Aeroperformance and acoustics of Bluebell-shaped and Telescope-shaped designs; (2) An analysis of sharp-edged nozzle exit designs for effective fuel injection into the flow stream in air-breathing engines: triangular-round, diamond-round and other nozzles; (3) Measurement technique improvement for the HU Low Speed Wind Tunnel; a new course in the field of aerodynamics, teaching and training of HU students; experimental tests of Mobius-shaped screws: research and training; (4) Supersonic inlet shape optimization. The main outcomes during this reporting period are: (l) Publications: The AIAA Paper #00-3170 was presented at the 36th AIAA/ASME/SAE/ASEE Joint Propulsion Conference, 17-19 June, 2000, Huntsville, AL. The AIAA Paper #01-1893 has been accepted for the AIAA/NAL-NASDA-ISAS 10th International Space Planes and Hypersonic Systems and Technologies Conference, 24-27 April 2001, Kyoto, Japan. The AIAA Paper #01 -3204 has been accepted for presentation at the 37th AIAA/ASME/SAE/ASEE Joint Propulsion Conference, being held on 08-11 July, in Salt Lake City, UT; (2) A U.S. patent #6,082,635 was granted on July 4, 2000; (3) Grants and proposals: The H U/ FM&AL was awarded the NASA grant NAG-3-2495 in October 2000 and the laboratory is a primary U.S. research team in a joint project under the CRDF award granted to the NASA GRC and IM/MSU (Russia) in July 2000; (4) Theory and numerical simulations: Analytical theory, numerical simulation, comparison of theoretical with experimental results, and modification of theoretical approaches, models, grids, etc., have been conducted for several complicated 2D and 3D nozzle and inlet designs using NASA, ICASE, and IM/MSU codes based on full Euler and Navier-Stokes solvers: CFL3D, FLUENT, and GODUNOV, and others; (5) Experimental Tests: (a) A new course: "Advanced Aerodynamics and Aircraft Performance" presented in spring semester, 2001; training and experimental test research using the HU LSWT. (b) Small-scale M6bius-shaped screws were tested in different conditions and their application has shown essential benefits by comparison with traditional designs; (6) Installation in the FM&AL computer system: second software TECPLOT 8.0 for the UNIX SGI workstation and free TECPLOT 7.5 for the PC Dell computer, and 2D and 3D GRIDGEN (version 9) for the UNIX SGI as well as installation of two free NASA codes, 3D MAG and VULCAN; (7) Student Research Activity: Involvement of two undergraduate students as research assistants in the current research project.

Fat mass to fat-free mass ratio reference values from NHANES III using bioelectrical impedance analysis.

PubMed

Xiao, J; Purcell, S A; Prado, C M; Gonzalez, M C

2017-10-06

Low fat-free mass (FFM) or high fat mass (FM) are abnormal body composition phenotypes associated with morbidity. These conditions in combination lead to worse health outcomes, and can be identified by a high FM/FFM ratio. Here, we developed sex, age, and body mass index (BMI) stratified, population-based FM/FFM reference values using bioelectrical impedance analysis (BIA) measurements. White, non-Hispanic individuals aged 18-90 years old with data for weight, stature and BIA resistance measures from the third National Health and Nutrition Examination Survey (NHANES) III were included. Previously validated and sex-specific BIA prediction equations were used to calculate FM and FFM. FM/FFM values were generated at 5th, 50th and 95th percentiles for each sex, age (18-39.9, 40-59.9, 60-69.9 and 70-90 years), and BMI category (underweight, normal weight, overweight, class I/II and class III obesity). A total of 6372 individuals who had estimated FM and FFM values were identified (3366 females, 3006 males). Median values of FM/FFM were 0.24 and 0.40 for young (≤39.9 years) males and females with normal BMI, and 0.34 for males and 0.59 for females who were overweight. For elderly individuals aged >70 years, median FM/FFM for males and females were respectively 0.28 and 0.45 for those with normal BMI, and 0.37 and 0.61 for those in the overweight category. These FM/FFM reference values provide information on body composition characteristics that account for age, sex and BMI, which can be useful to identify individuals at risk for body composition abnormalities. Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

27 CFR 53.157 - Deposit requirement for deposits made for calendar quarters prior to July 1, 1995.

Code of Federal Regulations, 2010 CFR

2010-04-01

... calendar quarter, the person deposits any underpayment for the month by the 9th day of the second month... quarter, the person deposits any underpayment for such month by the 9th day of the second month following... month in a calendar quarter, the person deposits any underpayment for such month by the 9th day of the...

The Effect of Scheduling Models for Introductory Algebra on 9th-Grade Students, Test Scores and Grades

ERIC Educational Resources Information Center

O'Hanlon, Angela L.

2011-01-01

The purpose of the study was to determine the effect of pacing and scheduling of algebra coursework on assigned 9th-grade students who traditionally would qualify for pre-algebra instruction and same course 9th-grade students who traditionally would qualify for standard algebra instruction. Students were selected based on completion of first-year…

Do different medical curricula influence self-assessed clinical thinking of students?

PubMed Central

Gehlhar, Kirsten; Klimke-Jung, Kathrin; Stosch, Christoph; Fischer, Martin R.

2014-01-01

Objectives: As a fundamental element of medical practice, clinical reasoning should be cultivated in courses of study in human medicine. To date, however, no conclusive evidence has been offered as to what forms of teaching and learning are most effective in achieving this goal. The Diagnostic Thinking Inventory (DTI) was developed as a means of measuring knowledge-unrelated components of clinical reasoning. The present pilot study examines the adequacy of this instrument in measuring differences in the clinical reasoning of students in varying stages of education in three curricula of medical studies. Methods: The Diagnostic Thinking Inventory (DTI) comprises 41 items in two subscales (“Flexibility in Thinking” and “Structure of Knowledge in Memory”). Each item contains a statement or finding concerning clinical reasoning in the form of a stem under which a 6-point scale presents opposing conclusions. The subjects are asked to assess their clinical thinking within this range. The German-language version of the DTI was completed by 247 student volunteers from three schools and varying clinical semesters. In a quasi-experimental design, 219 subjects from traditional and model courses of study in the German state of North Rhine-Westphalia took part. Specifically, these were 5th, 6th and 8th semester students from the model course of study at Witten/Herdecke University (W/HU), from the model (7th and 9th semester) and traditional (7th semester) courses of study at the Ruhr University Bochum (RUB) and from the model course of study (9th semester) at the University of Cologne (UoC). The data retrieved were quantitatively assessed. Results: The reliability of the questionnaire in its entirety was good (Cronbach’s alpha between 0.71 and 0.83); the reliability of the subscales ranged between 0.49 and 0.75. The different groups were compared using the Mann-Whitney test, revealing significant differences among semester cohorts within a school as well as between students from similar academic years in different schools. Among the participants from the model course of study at the W/HU, scores increased from the 5th to the 6th semester and from the 5th to the 9th semester. Among individual cohorts at RUB, no differences could be established between model and traditional courses of study or between 7th and 9th semester students in model courses of study. Comparing all participating highest semester students, the 8th semester participants from the W/HU achieved the highest scores – significantly higher than those of 9th semester RUB students or 9th semester UoC students. Scores from the RUB 9th semester participants were significantly higher than those of the 9th semester UoC participants. Discussion: The German-language version of the DTI measures self-assessed differences in diagnostic reasoning among students from various semesters and different model and traditional courses of study with satisfactory reliability. The results can be used for discussion in the context of diverse curricula. The DTI is therefore appropriate for further research that can then be correlated with the different teaching method characteristics and outcomes of various curricula. PMID:24872858

Do different medical curricula influence self-assessed clinical thinking of students?

PubMed

Gehlhar, Kirsten; Klimke-Jung, Kathrin; Stosch, Christoph; Fischer, Martin R

2014-01-01

As a fundamental element of medical practice, clinical reasoning should be cultivated in courses of study in human medicine. To date, however, no conclusive evidence has been offered as to what forms of teaching and learning are most effective in achieving this goal. The Diagnostic Thinking Inventory (DTI) was developed as a means of measuring knowledge-unrelated components of clinical reasoning. The present pilot study examines the adequacy of this instrument in measuring differences in the clinical reasoning of students in varying stages of education in three curricula of medical studies. The Diagnostic Thinking Inventory (DTI) comprises 41 items in two subscales ("Flexibility in Thinking" and "Structure of Knowledge in Memory"). Each item contains a statement or finding concerning clinical reasoning in the form of a stem under which a 6-point scale presents opposing conclusions. The subjects are asked to assess their clinical thinking within this range. The German-language version of the DTI was completed by 247 student volunteers from three schools and varying clinical semesters. In a quasi-experimental design, 219 subjects from traditional and model courses of study in the German state of North Rhine-Westphalia took part. Specifically, these were 5(th), 6(th) and 8(th) semester students from the model course of study at Witten/Herdecke University (W/HU), from the model (7(th) and 9(th) semester) and traditional (7(th) semester) courses of study at the Ruhr University Bochum (RUB) and from the model course of study (9(th) semester) at the University of Cologne (UoC). The data retrieved were quantitatively assessed. The reliability of the questionnaire in its entirety was good (Cronbach's alpha between 0.71 and 0.83); the reliability of the subscales ranged between 0.49 and 0.75. The different groups were compared using the Mann-Whitney test, revealing significant differences among semester cohorts within a school as well as between students from similar academic years in different schools. Among the participants from the model course of study at the W/HU, scores increased from the 5(th) to the 6(th) semester and from the 5(th) to the 9(th) semester. Among individual cohorts at RUB, no differences could be established between model and traditional courses of study or between 7(th) and 9(th) semester students in model courses of study. Comparing all participating highest semester students, the 8(th) semester participants from the W/HU achieved the highest scores - significantly higher than those of 9(th) semester RUB students or 9(th) semester UoC students. Scores from the RUB 9(th) semester participants were significantly higher than those of the 9(th) semester UoC participants. The German-language version of the DTI measures self-assessed differences in diagnostic reasoning among students from various semesters and different model and traditional courses of study with satisfactory reliability. The results can be used for discussion in the context of diverse curricula. The DTI is therefore appropriate for further research that can then be correlated with the different teaching method characteristics and outcomes of various curricula.

Analysis of Focal Mechanism and Microseismicity around the Lusi Mud Eruption Site, East Java, Indonesia

NASA Astrophysics Data System (ADS)

Karyono, Karyono; Obermann, Anne; Mazzini, Adriano; Lupi, Matteo; Syafri, Ildrem; Abdurrokhim, Abdurrokhim; Masturyono, Masturyono; Hadi, Soffian

2016-04-01

The 29th of May 2006 numerous eruption sites started in northeast Java, Indonesia following to a M6.3 earthquake striking the island.Within a few weeks an area or nearly 2 km2 was covered by boiling mud and rock fragments and a prominent central crater (named Lusi) has been erupting for the last 9.5 years. The M.6.3 seismic event also triggered the activation of the Watukosek strike slip fault system that originates from the Arjuno-Welirang volcanic complex and extends to the northeast of Java hosting Lusi and other mud volcanoes. Since 2006 this fault system has been reactivated in numerous instances mostly following to regional seismic and volcanic activity. However the mechanism controlling this activity have never been investigated and remain poorly understood. In order to investigate the relationship existing between seismicity, volcanism, faulting and Lusi activity, we have deployed a network of 31 seismometers in the framework of the ERC-Lusi Lab project. This network covers a large region that monitors the Lusi activity, the Watukosek fault system and the neighboring Arjuno-Welirang volcanic complex. In particular, to understand the consistent pattern of the source mechanism, relative to the general tectonic stress in the study area, a detailed analysis has been carried out by performing the moment tensor inversion for the near field data collected from the network stations. Furthermore these data have been combined with the near field data from the regional network of the Meteorological, Climatological and Geophysical Agency of Indonesia that covers the whole country on a broader scale. Keywords: Lusi, microseismic event, focal mechanism

Time spent in sedentary behavior and changes in childhood BMI: a longitudinal study from ages 9 to 15 years.

PubMed

Mitchell, J A; Pate, R R; Beets, M W; Nader, P R

2013-01-01

To determine if time spent in objectively measured sedentary behavior is associated with a change in body mass index (BMI) between ages 9 and 15 years, adjusting for moderate-to-vigorous physical activity (MVPA). Prospective observational study of children at ages 9 (2000), 11 (2002), 12 (2003) and 15 years (2006). Longitudinal quantile regression was used to model the influence of predictors on changes at the 10th, 25th, 50th, 75th and 90th BMI percentiles over time. Participants were enrolled in the National Institute of Child Health and Human Development (NICHD) Study of Early Child Care and Youth Development and include both boys and girls (n=789). Objectively measured BMI (kg m(-2)) was the outcome variable and objectively measured sedentary behavior was the main predictor. Adjustment was also made for MVPA, gender, race, maternal education, hours of sleep and healthy eating index. Increases in BMI were observed at all percentiles, with the greatest increase observed at the 90th BMI percentile. Spending more time in sedentary behavior (h per day) was associated with additional increases in BMI at the 90th, 75th and 50th BMI percentiles, independent of MVPA and the other covariates (90th percentile=0.59, 95% confidence interval (95% CI): 0.19-0.98 kg m(-2); 75th percentile=0.48, 95% CI: 0.25-0.72 kg m(-2); and 50th percentile=0.19, 95% CI: 0.05-0.33 kg m(-2)). No associations were observed between sedentary behavior and changes at the 25th and 10th BMI percentiles. Sedentary behavior was associated with greater increases in BMI at the 90th, 75th and 50th BMI percentiles between ages 9 and 15 years, independent of MVPA. Preventing an increase in sedentary behavior from childhood to adolescence may contribute to reducing the number of children classified as obese.

A benefit-risk analysis of rotavirus vaccination, France, 2015.

PubMed

Lamrani, Adnane; Tubert-Bitter, Pascale; Hill, Catherine; Escolano, Sylvie

2017-12-01

IntroductionTwo vaccines available for protection against rotavirus gastroenteritis (RVGE), Rotarix and RotaTeq, have contributed to a large decrease in the incidence of paediatric diarrhoea in countries where they have been used. However, they have also led to a small increase in the risk of intussusception. Methods: We compare the number of prevented hospitalisations for RVGE to the number of vaccine-induced hospitalised intussusceptions in France. Results: With 9.5% coverage (French 2015 estimation), vaccination was estimated to prevent, annually, a median of 1,074 hospitalisations (2.5th and 97.5th percentiles (2.5th-97.5th): 810-1,378) and 1.4 deaths (2.5th-97.5th: 1.2-1.6) from RVGE. It was also estimated to cause, annually, 5.0 hospitalisations (2.5th-97.5th: 3.2-7.7) and 0.005 deaths (2.5th-97.5th: 0.001-0.015) from intussusception. The benefit-risk ratio is therefore 214 (2.5th-97.5th: 128-362) for hospitalisations and 273 (2.5th-97.5th: 89-1,228) for deaths. Under a hypothetical 92% coverage, rotavirus vaccination with Rotarix would avoid 10,459 (2.5th-97.5th: 7,702-13,498) hospitalisations for RVGE and induce 47.0 (2.5th-97.5th: 25.1-81.4) hospitalisations for intussusception annually, thereby preventing 13.7 (2.5th-97.5th: 11.1-15.2) deaths and inducing 0.05 (2.5th-97.5th: 0.01-0.15) deaths. Conclusion: The benefit-risk ratio in France is similar to that of other European countries.

Investigation of the application of HCMM thermal data to snow hydrology. [Salt-Verde watershed, Arizona and Kings River Basin, California

NASA Technical Reports Server (NTRS)

Barnes, J. C. (Principal Investigator)

1980-01-01

The author has identified the following significant results. Analysis of HCMM digital thermal data for daytime passes over the Salt-Verde Watershed area on five dates show a gradual depletion of snow cover in the watershed (and in the Little Colorado Watershed to the north) from a maximum on February 9th to a nearly complete disappearance of the snow pack by April 15th. Temperature contours correspond closely with the snowline observed in the visible image.

Introduction.

PubMed

Ellerbroek, Brent L

2006-08-21

The OSA 2005 Special Topical Meeting on "Adaptive Optics: Analysis and Methods" was held in Charlotte, North Carolina, on June 8th and 9th of that year. The papers presented during those two days provided an overview of recent progress in the theory and application of adaptive optics (AO) for real-time atmospheric turbulence compensation. This Focus Issue is devoted to a further exploration of seven of these topics, ranging from formal analytical treatments of optimal estimation and control methods for AO, to recent field tests of wave front sensing and reconstruction using multiple laser guide stars.

No Need to Wait for Superman: A Case Study of One Unique High School

ERIC Educational Resources Information Center

Ratcliff, N. J.; Jones, C. R.; Costner, R. H.; Knight, C.; Disney, G.; Savage-Davis, E.; Sheehan, H.; Hunt, G. H.

2012-01-01

Based on a theoretical model developed by Schlechty, this case study focuses on a small high school, located on a college campus and designed to address the educational needs of gifted 9th- through 12th-grade students. Eight teachers who taught 9th- and 12th-grade classes and their 60 students were observed. Each teacher was observed during six…

Perceptions of 9th and 10th Grade Students on How Their Environment, Cognition, and Behavior Motivate Them in Algebra and Geometry Courses

ERIC Educational Resources Information Center

Harootunian, Alen

2012-01-01

In this study, relationships were examined between students' perception of their cognition, behavior, environment, and motivation. The purpose of the research study was to explore the extent to which 9th and 10th grade students' perception of environment, cognition, and behavior can predict their motivation in Algebra and Geometry courses. A…

To Study or to Sleep? The Academic Costs of Extra Studying at the Expense of Sleep

ERIC Educational Resources Information Center

Gillen-O'Neel, Cari; Huynh, Virginia W.; Fuligni, Andrew J.

2013-01-01

This longitudinal study examined how nightly variations in adolescents' study and sleep time are associated with academic problems on the following day. Participants ("N" = 535, 9th grade M[subscript age] = 14.88) completed daily diaries every day for 14 days in 9th, 10th, and 12th grades. Results suggest that regardless of how much a…

Long-term dynamic modeling of tethered spacecraft using nodal position finite element method and symplectic integration

NASA Astrophysics Data System (ADS)

Li, G. Q.; Zhu, Z. H.

2015-12-01

Dynamic modeling of tethered spacecraft with the consideration of elasticity of tether is prone to the numerical instability and error accumulation over long-term numerical integration. This paper addresses the challenges by proposing a globally stable numerical approach with the nodal position finite element method (NPFEM) and the implicit, symplectic, 2-stage and 4th order Gaussian-Legendre Runge-Kutta time integration. The NPFEM eliminates the numerical error accumulation by using the position instead of displacement of tether as the state variable, while the symplectic integration enforces the energy and momentum conservation of the discretized finite element model to ensure the global stability of numerical solution. The effectiveness and robustness of the proposed approach is assessed by an elastic pendulum problem, whose dynamic response resembles that of tethered spacecraft, in comparison with the commonly used time integrators such as the classical 4th order Runge-Kutta schemes and other families of non-symplectic Runge-Kutta schemes. Numerical results show that the proposed approach is accurate and the energy of the corresponding numerical model is conservative over the long-term numerical integration. Finally, the proposed approach is applied to the dynamic modeling of deorbiting process of tethered spacecraft over a long period.

Extent of areal inundation of riverine wetlands along Cypress Creek and the Peace, Alafia, North Prong Alafia, and South Prong Alafia Rivers, west-central Florida

USGS Publications Warehouse

Lewelling, B.R.

2003-01-01

Riverine and palustrine system wetlands are a major ecological component of river basins in west-central Florida. Healthy wetlands are dependent upon the frequency and duration of periodic flooding or inundation. This report assesses the extent, area, depth, frequency, and duration of periodic flooding and the effects of potential surface-water withdrawals on the wetlands along Cypress Creek and the Peace, Alafia, North Prong Alafia, and South Prong Alafia Rivers. Results of the study were derived from step-backwater analysis performed at each of the rivers using the U.S. Army Corps of Engineers Hydrologic Engineering Center-River Analysis System (HEC-RAS) one-dimensional model. The step-backwater analysis was performed using selected daily mean discharges at the 10th, 50th, 70th, 80th, 90th, 98th, 99.5th, and 99.9th percentiles to compute extent of areal inundation, area of inundation, and hydraulic depth to assess the net reduction of areal inundation if 10 percent of the total river flow were diverted for potential withdrawals. The extent of areal inundation is determined by cross-sectional topography and the degree to which the channel is incised. Areal inundation occurs along the broad, low relief of the Cypress Creek floodplain during all selected discharge percentiles. However, areal inundation of the Peace and Alafia Rivers floodplains, which generally have deeply incised channels, occurs at or above discharges at the 80th percentile. The greatest area of inundation along the three rivers generally occurs between the 90th and 98th percentile discharges. The decrease in inundated area resulting from a potential 10-percent withdrawal in discharge ranged as follows: Cypress Creek, 22 to 395 acres (1.7 to 8.4 percent); Peace River, 17 to 1,900 acres (2.1 to 13.6 percent); Alafia River, 1 to 90 acres (1 to 19.6 percent); North Prong Alafia River, 1 to 46 acres (0.7 to 23.4 percent); and South Prong Alafia River, 1 to 75 acres (1.5 to 13.4 percent).

PAd-shRNA-PTN reduces pleiotrophin of pancreatic cancer cells and inhibits neurite outgrowth of DRG

PubMed Central

Yao, Jun; Zhang, Min; Ma, Qing-Yong; Wang, Zheng; Wang, Lian-Cai; Zhang, Dong

2011-01-01

AIM: To investigate the silencing effects of pAd-shRNA-pleiotrophin (PTN) on PTN in pancreatic cancer cells, and to observe the inhibition of pAd-shRNA-PTN on neurite outgrowth from dorsal root ganglion (DRG) neurons in vitro. METHODS: PAd-shRNA-PTN was used to infect pancreatic cancer BxPC-3 cells; assays were conducted for knockdown of the PTN gene on the 0th, 1st, 3rd, 5th, 7th and 9th d after infection using immunocytochemistry, real-time quantitative polymerase chain reaction (PCR), and Western blotting analysis. The morphologic changes of cultured DRG neurons were observed by mono-culture of DRG neurons and co-culture with BXPC-3 cells in vitro. RESULTS: The real-time quantitative PCR showed that the inhibition rates of PTN mRNA expression in the BxPC-3 cells were 20%, 80%, 50% and 25% on the 1st, 3rd, 5th and 7th d after infection. Immunocytochemistry and Western blotting analysis also revealed the same tendency. In contrast to the control, the DRG neurons co-cultured with the infected BxPC-3 cells shrunk; the number and length of neurites were significantly decreased. CONCLUSION: Efficient and specific knockdown of PTN in pancreatic cancer cells and the reduction in PTN expression resulted in the inhibition of neurite outgrowth from DRG neurons. PMID:21677838

Short-Term Effect of Ambient Temperature and the Risk of Stroke: A Systematic Review and Meta-Analysis

PubMed Central

Lian, Hui; Ruan, Yanping; Liang, Ruijuan; Liu, Xiaole; Fan, Zhongjie

2015-01-01

Background and Purpose: The relationship between stroke and short-term temperature changes remains controversial. Therefore, we conducted a systematic review and meta-analysis to investigate the association between stroke and both high and low temperatures, and health assessment. Methods: We searched PubMed, Embase, Cochrane, China National Knowledge Infrastructure (CNKI) and Wanfang Data up to 14 September 2014. Study selection, quality assessment, and author-contractions were steps before data extraction. We converted all estimates effects into relative risk (RR) per 1 °C increase/decrease in temperature from 75th to 99th or 25th to 1st percentiles, then conducted meta-analyses to combine the ultimate RRs, and assessed health impact among the population. Results: 20 articles were included in the final analysis. The overall analysis showed a positive relationship between 1 °C change and the occurrence of major adverse cerebrovascular events (MACBE), 1.1% (95% confidence intervals (CI), 0.6 to 1.7) and 1.2% (95% CI, 0.8 to 1.6) increase for hot and cold effects separately. The same trends can be found in both effects of mortality and the cold effect for morbidity. Hot temperature acted as a protective factor of hemorrhage stroke (HS), −1.9% (95% CI, −2.8 to −0.9), however, it acted as a risk factor for ischemic stroke (IS), 1.2% (95% CI, 0.7 to 1.8). Conclusion: Short-term changes of both low and high temperature had statistically significant impacts on MACBE. PMID:26264018

Serum Gelatinases Levels in Multiple Sclerosis Patients during 21 Months of Natalizumab Therapy

PubMed Central

Bellini, Tiziana; Trentini, Alessandro; Delbue, Serena; Elia, Francesca; Gastaldi, Matteo; Franciotta, Diego; Bergamaschi, Roberto; Manfrinato, Maria Cristina; Volta, Carlo Alberto; Granieri, Enrico; Fainardi, Enrico

2016-01-01

Background. Natalizumab is a highly effective treatment approved for multiple sclerosis (MS). The opening of the blood-brain barrier mediated by matrix metalloproteinases (MMPs) is considered a crucial step in MS pathogenesis. Our goal was to verify the utility of serum levels of active MMP-2 and MMP-9 as biomarkers in twenty MS patients treated with Natalizumab. Methods. Serum levels of active MMP-2 and MMP-9 and of specific tissue inhibitors TIMP-1 and TIMP-2 were determined before treatment and for 21 months of therapy. Results. Serum levels of active MMP-2 and MMP-9 and of TIMP-1 and TIMP-2 did not differ during the treatment. The ratio between MMP-9 and MMP-2 was increased at the 15th month compared with the 3rd, 6th, and 9th months, greater at the 18th month than at the 3rd and 6th months, and higher at the 21st than at the 3rd and 6th months. Discussion. Our data indicate that an imbalance between active MMP-9 and active MMP-2 can occur in MS patients after 15 months of Natalizumab therapy; however, they do not support the use of serum active MMP-2 and active MMP-9 and TIMP-1 and TIMP-2 levels as biomarkers for monitoring therapeutic response to Natalizumab. PMID:27340316

The Effect of Conceptual Change Approach to Eliminate 9th Grade High School Students' Misconceptions about Air Pressure

ERIC Educational Resources Information Center

Akbas, Yavuz; Gencturk, Ebru

2011-01-01

The aim of this study was to determine the effectiveness of teaching based on conceptual change overcome misconceptions of 9th grade high school students about the subject of air pressure. The sampling of the study was formed with two classes of 9th grade students from a general high school in the city-center of Trabzon. A quasi-experimental…

The Effectiveness of a Self Regulated Learning-Based Training Program on Improving Cognitive and Metacognitive EFL Reading Comprehension of 9th Graders with Reading Disabilities

ERIC Educational Resources Information Center

Eissa, Mourad Ali

2015-01-01

The purpose of this study was to explore the effect of a self regulated learning intervention program on cognitive and metacognitive EFL reading comprehension of 9th graders with reading disabilities. The participants in this study were 40 9th Graders with reading disabilities, selected from two schools located in Baltim Educational Edara. A…

Advances in Laser Microprobe (U-Th)/He Geochronology

NASA Astrophysics Data System (ADS)

van Soest, M. C.; Monteleone, B. D.; Boyce, J. W.; Hodges, K. V.

2008-12-01

The development of the laser microprobe (U-Th)/He dating method has the potential to overcome many of the limitations that affect conventional (U-Th)/He geochronology. Conventional single- or multi-crystal (U- Th)/He geochronology requires the use of pristine, inclusion-free, euhedral crystals. Furthermore, the ages that are obtained require corrections for the effects of zoning and alpha ejection based on an ensemble of assumptions before interpretation of their geological relevance is possible. With the utilization of microbeam techniques many of the limitations of conventional (U-Th)/He geochronology can either be eliminated by careful spot selection or accounted for by detailed depth profiling analyses of He, U and Th on the same crystal. Combined He, Th, and U depth profiling on the same crystal potentially even offers the ability to extract thermal histories from the analyzed grains. Boyce et al. (2006) first demonstrated the laser microprobe (U-Th)/He dating technique by successfully dating monazite crystals using UV laser ablation to liberate He and determined U and Th concentrations using a Cameca SX-Ultrachron microprobe. At Arizona State University, further development of the microprobe (U-Th)/He dating technique continues using an ArF Excimer laser connected to a GVI Helix Split Flight Tube noble gas mass spectrometer for He analysis and SIMS techniques for U and Th. The Durango apatite age standard has been successfully dated at 30.7 +/- 1.7 Ma (2SD). Work on dating zircons by laser ablation is currently underway, with initial results from Sri Lanka zircon at 437 +/- 14 Ma (2SD) confirmed by conventional (U-Th)/He analysis and in agreement with the published (U-Th)/He age of 443 +/- 9 Ma (2SD) for zircons from this region in Sri Lanka (Nasdala et al., 2004). The results presented here demonstrate the laser microprobe (U-Th)/He method as a powerful tool that allows application of (U- Th)/He dating to areas of research such as detrital apatite and zircon dating, where conventional (U-Th)/He geochronology has limited applicability. Boyce et al. (2006) GCA 70 (3031-3039), Nasdala et al. (2004) Am. Min. 89 (219-231)

Saturated in beer: awareness of beer advertising in late childhood and adolescence.

PubMed

Collins, Rebecca L; Ellickson, Phyllis L; McCaffrey, Daniel F; Hambarsoomians, Katrin

2005-07-01

The purpose of this study was to examine exposure, response to, and awareness of beer advertising in 2 age groups, including awareness of a Budweiser advertisement (ad) that portrayed lizards and an animated ferret. In the spring of 2000, 1,996 fourth graders and 1,525 ninth graders attending 1 of 60 South Dakota schools participated in an in-school survey. Several indicators of advertising awareness, exposure, and response were assessed: recognition, product naming, brand naming, and liking in response to stills drawn from 4 masked television beer ads, listing of beer brands, exposure, attention to, and skepticism toward television beer ads. Fourteen percent of 4th graders and 20% of 9th graders recognized at least 3 of 4 sample beer ads. Seventy-five percent of 4th graders and 87% of 9th graders recognized the Budweiser ferret ad; about one in three 4th graders could name the brand it advertised, whereas more than three in four 9th graders could do so. When asked to list as many beer brands as they could, almost 29% of 4th graders listed 3 or more beer brands and 82% of 9th graders did so. Ninth graders liked beer advertisements more and paid greater attention to them, but 4th graders were exposed to them more often. Television beer ads result in high levels of beer advertising awareness in children as young as age 9, and even higher awareness among 14-year-olds. Practices that expose or appeal to youth, including use of animated characters, should be avoided by beer advertisers.

Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins

PubMed Central

Yano, Junko; Noverr, Mairi C.; Fidel, Paul L.

2011-01-01

Vulvovaginal candidiasis (VVC), caused by Candida albicans, affects a significant number of women during their reproductive years. More than two decades of research have been focused on the mechanisms associated with susceptibility or resistance to symptomatic infection. Adaptive immunity by Th1-type CD4+ T cells and downstream cytokine responses are considered the predominant host defense mechanisms against mucosal Candida infections. However, numerous clinical and animal studies have indicated no or limited protective role of cells and cytokines of the Th1 or Th2 lineage against vaginal infection. The role for Th17 is only now begun to be investigated in-depth for VVC with results already showing significant controversy. On the other hand, a clinical live-challenge study and an established animal model have shown that a symptomatic condition is intimately associated with the vaginal infiltration of polymorphonuclear leukocytes (PMNs) but with no effect on vaginal fungal burden. Subsequent studies identified S100A8 and S100A9 Alarmins as key chemotactic mediators of the acute PMN response. These chemotactic danger signals appear to be secreted by vaginal epithelial cells upon interaction and early adherence of Candida. Thus, instead of a putative immunodeficiency against Candida involving classical immune cells and cytokines of the adaptive response, the pathological inflammation in VVC is now considered a consequence of a non-productive innate response initiated by non-classical immune mediators. PMID:22182685

Use of synthetic cathinones and cannabimimetics among injection drug users in San Diego, California

PubMed Central

Wagner, Karla D.; Armenta, Richard F.; Roth, Alexis M.; Maxwell, Jane C.; Cuevas-Mota, Jazmine; Garfein, Richard S.

2014-01-01

Background Use of synthetic cathinones (SC) and cannabimimetics (i.e., “THC homologues” [TH]) is associated with adverse health effects. We investigated the epidemiology of synthetic drug use among a cohort of injection drug users (IDUs) in San Diego, California. Methods We used logistic regression analysis to identify correlates of SC and TH use among 485 IDUs enrolled from June 2012 to September 2013. Results Seven percent of participants reported ever using SC and 30% reported ever using TH. In multivariate logistic regression, age and recent hospitalization were significantly associated with odds of SC use (Adjusted Odds Ratio [AOR] 0.93, 95% Confidence Interval [C.I.] 0.90, 0.97; and AOR 2.34 95% C.I. 1.00, 5.49, respectively) and TH use (AOR 0.96, 95% C.I. 0.94, 0.98; and AOR 2.62, 95% C.I. 1.47, 4.68, respectively). Use of methamphetamine (AOR 9.35, 95% C.I. 1.20, 72.79) and club drugs in the past six months (AOR 3.38, 95% C.I. 1.17, 9.76) were significantly associated with SC use. Being on probation/parole (AOR 2.42, 95% C.I. 1.44,4.07), initiating injection drug use with stimulants (AOR 1.89 95% C.I. 1.13, 3.16), and past six-month marijuana (AOR 9.22, 95% C.I. 4.49, 18.96) and prescription drug use (AOR 1.98, 95% C.I. 1.20, 3.27) were significantly associated with TH use. Conclusions A considerable proportion of IDU use synthetic drugs and may experience harms associated with their use. Findings have implications for criminal justice system management. Prevention efforts should emphasize the risks associated with rapidly changing synthetic formulations, and the potential harms associated with polydrug use. PMID:24916748

An investigation of the relationships between junior high school students' (8th and 9th grades) background variables and structure of knowledge recall of biological content

NASA Astrophysics Data System (ADS)

Demetrius, Olive Joyce

The purpose of this study was to examine the relationships between Junior High School students' (8th and 9th grades) background variables (e.g. cognitive factors, prior knowledge, preference for science versus non-science activities, formal and informal activities) and structure of information recall of biological content. In addition, this study will illustrate how flow maps, a graphic display, designed to represent the sequential flow and cross linkage of ideas in information recalled by the learner can be used as a tool for analyzing science learning data. The participants (46 junior high school students) were taught a lesson on the human digestive system during which they were shown a model of the human torso. Their pattern of information recall was determined by using an interview technique to elicit their understanding of the functional anatomy of the human digestive system. The taped responses were later transcribed for construction of the flow map. The interview was also used to assess knowledge recall of biological content. The flow map, science interest questionnaire and the cognitive operations (based on content analysis of student's narrative) were used to analyze data from each respondent. This is a case study using individual subjects and interview techniques. The findings of this study are: (1) Based on flow map data higher academic ability students have more networking of ideas than low ability students. (2) A large percentage of 9th grade low ability students intend to pursue science/applied science course work after leaving school but they lack well organized ways of representing science knowledge in memory. (3) Content analysis of the narratives shows that students with more complex ideational networks use higher order cognitive thought processes compared to those with less networking of ideas. If students are to make a successful transition from low academic performance to high academic performance it seems that more emphasis should be placed on information networking skills. This is specifically likely to be productive for student currently performing on low academic ability levels and yet have high aspirations for pursuing science as a career.

Elevated serum galectin-9 levels in patients with atopic dermatitis.

PubMed

Nakajima, Rina; Miyagaki, Tomomitsu; Oka, Tomonori; Nakao, Momoko; Kawaguchi, Makiko; Suga, Hiraku; Morimura, Sohshi; Kai, Hiromichi; Asano, Yoshihide; Tada, Yayoi; Kadono, Takafumi; Sato, Shinichi; Sugaya, Makoto

2015-07-01

Galectin-9 is a member of the galectin family that has a wide spectrum of biological functions. Among them, galectin-9 has been known mainly as a potent chemoattractant for eosinophils. In addition, galectin-9 alters the T-cell balance by negatively regulating T-helper (Th)1 and Th17 cells, resulting in Th2 polarization. Atopic dermatitis (AD) is a skin allergic disease characterized by peripheral eosinophilia, mast cell activation and predominance of Th2 cells. To investigate possible roles of galectin-9 in AD, we measured serum galectin-9 levels in AD patients and investigated galectin-9 expression in lesional skin by immunohistochemistry. Serum galectin-9 levels in patients with AD were significantly higher than those in healthy controls and correlated with the Eczema Area and Severity Index. Serum galectin-9 levels were decreased after treatment, accompanied by improvement of skin lesions. Immunohistochemical study revealed that galectin-9 was expressed on epidermal keratinocytes and mast cells in lesional skin of AD. Our results suggest that elevated galectin-9 expression is associated with progression of AD and that galectin-9 could be a therapeutic target in AD. © 2015 Japanese Dermatological Association.

Individual Differences in Algebraic Cognition: Relation to the Approximate Number and Sematic Memory Systems

PubMed Central

Geary, David C.; Hoard, Mary K.; Nugent, Lara; Rouder, Jeffrey N.

2015-01-01

The relation between performance on measures of algebraic cognition and acuity of the approximate number system (ANS) and memory for addition facts was assessed for 171 (92 girls) 9th graders, controlling parental education, sex, reading achievement, speed of numeral processing, fluency of symbolic number processing, intelligence, and the central executive component of working memory. The algebraic tasks assessed accuracy in placing x,y pairs in the coordinate plane, speed and accuracy of expression evaluation, and schema memory for algebra equations. ANS acuity was related to accuracy of placements in the coordinate plane and expression evaluation, but not schema memory. Frequency of fact-retrieval errors was related to schema memory but not coordinate plane or expression evaluation accuracy. The results suggest the ANS may contribute to or is influenced by spatial-numerical and numerical only quantity judgments in algebraic contexts, whereas difficulties in committing addition facts to long-term memory may presage slow formation of memories for the basic structure of algebra equations. More generally, the results suggest different brain and cognitive systems are engaged during the learning of different components of algebraic competence, controlling demographic and domain general abilities. PMID:26255604

Noise level in a neonatal intensive care unit in Santa Marta - Colombia.

PubMed

Garrido Galindo, Angélica Patricia; Camargo Caicedo, Yiniva; Velez-Pereira, Andres M

2017-09-30

The environment of neonatal intensive care units is influenced by numerous sources of noise emission, which contribute to raise the noise levels, and may cause hearing impairment and other physiological and psychological changes on the newborn, as well as problems with care staff. To evaluate the level and sources of noise in the neonatal intensive care unit. Sampled for 20 consecutive days every 60 seconds in A-weighting curves and fast mode with a Type I sound level meter. Recorded the average, maximum and minimum, and the 10th, 50th and 90th percentiles. The values are integrated into hours and work shift, and studied by analysis of variance. The sources were characterized in thirds of octaves. The average level was 64.00 ±3.62 dB(A), with maximum of 76.04 ±5.73 dB(A), minimum of 54.84 ±2.61dB(A), and background noise of 57.95 ±2.83 dB(A). We found four sources with levels between 16.8-63.3 dB(A). Statistical analysis showed significant differences between the hours and work shift, with higher values in the early hours of the day. The values presented exceed the standards suggested by several organizations. The sources identified and measured recorded high values in low frequencies.

Determination of Paleoseismic Ground Motions from Inversion of Block Failures in Masonry Structures

NASA Astrophysics Data System (ADS)

Yagoda-Biran, G.; Hatzor, Y. H.

2010-12-01

Accurate estimation of ground motion parameters such as expected peak ground acceleration (PGA), predominant frequency and duration of motion in seismically active regions, is crucial for hazard preparedness and sound engineering design. The best way to estimate quantitatively these parameters would be to investigate long term recorded data of past strong earthquakes in a studied region. In some regions of the world however recorded data are scarce due to lack of seismic network infrastructure, and in all regions the availability of recorded data is restricted to the late 19th century and onwards. Therefore, existing instrumental data are hardly representative of the true seismicity of a region. When recorded data are scarce or not available, alternative methods may be applied, for example adopting a quantitative paleoseismic approach. In this research we suggest the use of seismically damaged masonry structures as paleoseismic indicators. Visitors to archeological sites all over the world are often struck by structural failure features which seem to be "seismically driven", particularly when inspecting old masonry structures. While it is widely accepted that no other loading mechanism can explain the preserved damage, the actual driving mechanism remains enigmatic even now. In this research we wish to explore how such failures may be triggered by earthquake induced ground motions and use observed block displacements to determine the characteristic parameters of the paleoseismic earthquake motion, namely duration, frequency, and amplitude. This is performed utilizing a 3D, fully dynamic, numerical analysis performed with the Discontinuous Deformation Analysis (DDA) method. Several case studies are selected for 3D numerical analysis. First we study a simple structure in the old city of L'Aquila, Italy. L'Aquila was hit by an earthquake on April 6th, 2009, with over 300 casualties and many of its medieval buildings damaged. This case study is an excellent opportunity to validate our method, since in the case of L'Aquila, both the damaged structure and the ground motions are recorded. The 3D modeling of the structure is rather complicated, and is performed by first modeling the structure with CAD software and later "translating" the model to the numerical code used. In the future, several more case studies will be analyzed, such as Kedesh and Avdat in Israel, and in collaboration with Hugh and Bilham the Temple of Shiva at Pandrethan, Kashmir. Establishing a numerical 3D dynamic analysis for back analysis of stone displacement in masonry structures as a paleoseismic tool can provide much needed data on ground motion parameters in regions where instrumental data are scarce, or are completely absent.

33 CFR 117.559 - Isle of Wight (Sinepuxent) Bay.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 4, the draw need not open from 9:30 p.m. until 10:30 p.m. to accommodate the annual July 4th... need not open from 9:30 p.m. until 10:30 p.m. on July 5th to accommodate the annual July 4th fireworks...

33 CFR 117.559 - Isle of Wight (Sinepuxent) Bay.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 4, the draw need not open from 9:30 p.m. until 10:30 p.m. to accommodate the annual July 4th... need not open from 9:30 p.m. until 10:30 p.m. on July 5th to accommodate the annual July 4th fireworks...

Nonsuicidal Self-Injury among "Privileged" Youths: Longitudinal and Cross-Sectional Approaches to Developmental Process

ERIC Educational Resources Information Center

Yates, Tuppett M.; Tracy, Allison J.; Luthar, Suniya S.

2008-01-01

This investigation examined process-level pathways to nonsuicidal self-injury (NSSI; e.g., self-cutting, -burning, -hitting) in 2 cohorts of suburban, upper-middle-class youths: a cross-sectional sample of 9th-12th graders (n = 1,036, 51.9% girls) on the West Coast and a longitudinal sample followed annually from the 6th through 12th grades (n =…

Coeducational or Single-Sex School: Does It Make a Difference on High School Girls' Academic Motivation?

ERIC Educational Resources Information Center

Chouinard, Roch; Vezeau, Carole; Bouffard, Therese

2008-01-01

The aim of the present study was to further examine the impact over time of single-sex and coeducational school environments on girls' motivation in language arts and mathematics. Two cohorts comprising 340 girls (7th to 9th grade; 9th to 11th grade) from eight coeducational and two single-sex schools were followed during a period of three…

The Basic Program of Vocational Agriculture in Louisiana. Ag I and Ag II (9th and 10th Grades). Volume I. Bulletin 1690-I.

ERIC Educational Resources Information Center

Louisiana State Dept. of Education, Baton Rouge. Div. of Vocational Education.

This document is the first volume of a state curriculum guide on vocational agriculture for use in the 9th and 10th grades in Louisiana. Three instructional areas are profiled in this volume: orientation to vocational agriculture, agricultural leadership, and soil science. The three units of the orientation area cover introducing beginning…

Clinical aspects of neurodegenerative diseases - 15th HUPO BPP Workshop April 8-9, 2011, Bochum, Germany.

PubMed

Gröttrup, Bernd; Böckmann, Miriam; Marcus, Katrin; Wiltfang, Jens; Grinberg, Lea T; Meyer, Helmut E; Park, Young M

2011-11-01

The HUPO Brain Proteome Project (HUPO BPP) held its 15th workshop in Bochum, Germany, from April 8th to 9th, 2011 directly after the Proteomic Forum 2011 in Berlin. Like on every spring workshop, the focus was more on clinical aspects, so that especially clinicians participated in this workshop. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

76 FR 57806 - Citizens Coinage Advisory Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-16

..., 2011. Time: 9 a.m. to 12 noon. Location: Conference Room A, United States Mint, 801 9th Street, NW... CONTACT: Andy Fishburn, United States Mint Liaison to the CCAC; 801 9th Street, NW.; Washington, DC 20220...

Spectral flux from low-density photospheres - Numerical results

NASA Technical Reports Server (NTRS)

Hershkowitz, S.; Linder, E.; Wagoner, R. V.

1986-01-01

Radiative transfer through sharp, quasi-static atmospheres whose opacity is dominated by hydrogen is considered at densities low enough that scattering usually dominates absorption and radiative excitations usually dominate collisional excitations. Numerical results for the continuum spectral flux are obtained for effective temperatures T(e) = 6000-16,000 K and scale heights Delta-R = 10 to the 10th - 10 to the 14th cm. Spectra are significantly different than if LTE level populations were assumed. Comparison with observations of the Type II supernova 1980k tends to increase the value of the Hubble constant previously obtained by the Baade (1926) method.

A Topical Trajectory on Survival: An Analysis of Link-Making in a Sequence of Lessons on Evolution

ERIC Educational Resources Information Center

Rocksén, Miranda; Olander, Clas

2017-01-01

This study explores the concept of link-making in relation to communicative strategies applied in the teaching and studying of biological evolution. The analysis focused on video recordings of 11 lessons on biological evolution conducted in a Swedish 9th grade class of students aged 15 years. It reveals how the teacher and students connected…

[The teaching and practice of ars dictaminis from the 12(th) to the 14 (th) century].

PubMed

Grévin, Benoît

2012-01-01

The medieval discipline of the ars dictaminis (or dictamen), which flourished during the 12(th)-14(th) centuries, can be considered as an adaptation of classical Latin rhetoric to the communicational needs of the medieval society. Yet, although the relation between the teaching of the ars and its practice is an important one, it has rarely been addressed because of the persistence of numerous misunderstandings about the various different levels at which the ars was taught. This article offers some suggestions to fill this gap.

A combined experimental and computational thermodynamic investigation of the U-Th-O system

DOE PAGES

McMurray, Jake Wesley; Voit, Stewart L.; Besmann, Theodore M.

2016-03-21

Here, the thermodynamics of the U–Th–O system have been assessed using the Calphad method. The compound energy formalism (CEF) and a partially ionic two-sublattice liquid model (TSLM) were used for the fluorite U 1–yTh yO 2±x, γ-(U,Th) 4O 9, and the U–Th–O melt. The O 2 activity of fluorite U 1–yTh yO 2±x with temperature and composition was determined by thermogravimetric analysis. Thermodynamic studies for the Th–O binary and U–Th–O ternary available in the open literature were critically reviewed. A self-consistent data set was selected and compiled with the equilibrium oxygen pressures determined by thermogravimetry in order to optimize themore » adjustable parameters of models selected to represent the phases in the Th–O and U–Th–O systems.« less

CRCP-9: Improved Computer Program for Mechanistic Analysis of Continuously Reinforced Concrete Pavements

DOT National Transportation Integrated Search

2001-02-01

A new version of the CRCP computer program, CRCP-9, has been developed in this study. The numerical model of the CRC pavements was developed using finite element theories, the crack spacing prediction model was developed using the Monte Carlo method,...

Comprehensive analysis of heat transfer of gold-blood nanofluid (Sisko-model) with thermal radiation

NASA Astrophysics Data System (ADS)

Eid, Mohamed R.; Alsaedi, Ahmed; Muhammad, Taseer; Hayat, Tasawar

Characteristics of heat transfer of gold nanoparticles (Au-NPs) in flow past a power-law stretching surface are discussed. Sisko bio-nanofluid flow (with blood as a base fluid) in existence of non-linear thermal radiation is studied. The resulting equations system is abbreviated to model the suggested problem in non-linear PDEs. Along with initial and boundary-conditions, the equations are made non-dimensional and then resolved numerically utilizing 4th-5th order Runge-Kutta-Fehlberg (RKF45) technique with shooting integration procedure. Various flow quantities behaviors are examined for parametric consideration such as the Au-NPs volume fraction, the exponentially stretching and thermal radiation parameters. It is observed that radiation drives to shortage the thermal boundary-layer thickness and therefore resulted in better heat transfer at surface.

The Effect of Arabism of Romanic Alphabets on the Development of 9th Grade English as a Foreign Language Students' Writing Skills at Secondary School Level

ERIC Educational Resources Information Center

Zuhair, Ahmad

2015-01-01

This paper aims at investigating the effect of Arabization of Romanic Alphabets on the development of 9th Grade English as a Foreign Language students' composition writing skills at secondary school level. This experimental study includes 25 secondary school students in their 9th Grade in which English is taught as a foreign language at…

Optimal Ranking Regime Analysis of TreeFlow Dendrohydrological Reconstructions

NASA Astrophysics Data System (ADS)

Mauget, S. A.

2017-12-01

The Optimal Ranking Regime (ORR) method was used to identify 6-100 year time windows containing significant ranking sequences in 55 western U.S. streamflow reconstructions, and reconstructions of the level of the Great Salt Lake and San Francisco Bay salinity during 1500-2007. The method's ability to identify optimally significant and non-overlapping runs of low and high rankings allows it to re-express a reconstruction time series as a simplified sequence of regime segments marking intra- to multi-decadal (IMD) periods of low or high streamflow, lake level, or salinity. Those ORR sequences, referred to here as Z-lines, can be plotted to identify consistent regime patterns in the analysis of numerous reconstructions. The Z-lines for the 57 reconstructions evaluated here show a common pattern of IMD cycles of drought and pluvial periods during the late 16th and 17th centuries, a relatively dormant period during the 18th century, and the reappearance of alternating dry and wet IMD periods during the 19th and early 20th centuries. Although this pattern suggests the possibility of similarly active and inactive oceanic modes in the North Pacific and North Atlantic, such centennial-scale patterns are not evident in the ORR analyses of reconstructed Pacific Decadal Oscillation (PDO), El Niño-Southern Oscillation, and North Atlantic seas-surface temperature variation. But given the inconsistency in the analyses of four PDO reconstructions the possible role of centennial-scale oceanic mechanisms is uncertain. In future research the ORR method might be applied to climate reconstructions around the Pacific Basin to try to resolve this uncertainty. Given its ability to compare regime patterns in climate reconstructions derived using different methods and proxies, the method may also be used in future research to evaluate long-term regional temperature reconstructions.

Capacity for self-monitoring reading comprehension in Elementary School.

PubMed

Bueno, Gabriela Juliane; Carvalho, Carolina Alves Ferreira; Ávila, Clara Regina Brandão de

2017-06-08

To investigate the capacity for self-monitoring reading comprehension in Brazilian Elementary School students. Fifty-three Elementary students in the 5th and 9th grades from two Public Schools in the city of São Paulo were assessed. They were selected based on their oral reading rate and grouped according to their performance in reading comprehension in the following categories: Group with best comprehension: students with adequate rate and accuracy, without difficulties in reading comprehension; Group with worst comprehension: students with adequate rate and accuracy but with difficulties in reading comprehension. Two narrative texts followed by eight questions to assess reading comprehension were presented. Two sentences and two words were replaced by ungrammatical elements and pseudo-words. Under the condition of spontaneous monitoring, students read the text aloud and answered the questions. The analysis considered the calculation of hesitation, self-correction, repetitions and mistakes. Under the condition of directed monitoring, students were instructed to read the text, either aloud or silently, after being told that certain parts of the text could not make sense, and they were oriented to underline such parts. The analysis was carried out by counting of underlined items. The comparisons were made with the Mann-Whitney test. A difference was observed between the groups only at the sentence level among the 9th grade schoolchildren under the spontaneous monitoring and among the 5th grade schoolchildren under directed monitoring. Students with worst comprehension had a poorer performance to monitor the presence of ungrammatical sentences than their peers with best comprehension.

The relationship of body mass index and blood pressure in Iranian children <7 years old.

PubMed

Ataei, Neamatollah; Hosseini, Mostafa; Iranmanesh, Mohammad

2009-10-01

The objective of this study was to evaluate the association between the body mass index (BMI), in healthy young children with their blood pressure (BP). The study included 3186 healthy children aged 1-6 years who were studied between March 2004 and March 2007 in different kindergartens and health centers in Tehran. Each child was classified on the basis of age- and sex-specific BMI percentile as normal weight (BMI <85th percentile), at risk for overweight (BMI >85th and <95th percentile), or overweight (BMI > or =95th percentile). Systolic BP (SBP) and diastolic BP (DBP) was compared among age-sex-BMI groups. Among children aged below 7 years in kindergartens and health centers in Tehran, 7.2% were at risk of overweight and 12.2% were overweight. These proportions were similar for boys and girls and were as follows: 6.9%, 13.9% and 7.5%, 10.5%, respectively. Analysis of variance showed that mean SBP significantly increased according to age (p < 0.0001) and BMI group (p = 0.001). Analysis of variance also showed that mean DBP significantly increased as age increased (p < 0.0001), but no significant difference was found between boys and girls in different age and BMI groups (p = 0.37). Our survey identified a high prevalence of overweight that was associated with elevated SBP among preschool-aged children in Iran. The effect of higher BMI on mean SBP is present in childhood and can be used as a predictor of high SBP even in children as young as 1-6 years.

Exciting Normal Distribution

ERIC Educational Resources Information Center

Fuchs, Karl Josef; Simonovits, Reinhard; Thaller, Bernd

2008-01-01

This paper describes a high school project where the mathematics teaching and learning software M@th Desktop (MD) based on the Computer Algebra System Mathematica was used for symbolical and numerical calculations and for visualisation. The mathematics teaching and learning software M@th Desktop 2.0 (MD) contains the modules Basics including tools…

Efficient Resource Utilization in the Bayne-Jones Army Community Hospital Emergency Room

DTIC Science & Technology

1990-08-07

34 Previous editions are obsolete. SECURITY CLASSIFICATION OF THIS PAGE MI 9e9TEbc9$ff c6 Apxv~ k puUilt, -t 2A m BOCK #19 (continued) IT on ER patients...performed by nurses. American Journal of Public Health, 1989 Edition . (1989). Chicago: American Hospital Association. American College of Emergency Physicians... 6th Ed. New York: McGraw-Hill Book Company. Liptak, G.S., Super, D.M., Baker, N., & Roghmann, K.J. (1985). An analysis of waiting times in a pediatric

Non-invasive tool for foetal sex determination in early gestational age.

PubMed

Mortarino, M; Garagiola, I; Lotta, L A; Siboni, S M; Semprini, A E; Peyvandi, F

2011-11-01

Free foetal DNA in maternal blood during early pregnancy is an ideal source of foetal genetic material for non-invasive prenatal diagnosis. The aim of this study was to evaluate the use of free foetal DNA analysis at early gestational age as pretest for the detection of specific Y-chromosome sequences in maternal plasma of women who are carriers of X-linked disorders, such as haemophilia. Real-time quantitative PCR analysis of maternal plasma was performed for the detection of the SRY or DYS14 sequence. A group of 208 pregnant women, at different gestational periods from 4 to 12 weeks, were tested to identify the optimal period to obtain an adequate amount of foetal DNA for prenatal diagnosis. Foetal gender was determined in 181 pregnant women sampled throughout pregnancy. Pregnancy outcome and foetal gender were confirmed using karyotyping, ultrasonography or after birth. The sensitivity, which was low between 4th and 7th week (mean 73%), increased significantly after 7+1th weeks of gestation (mean 94%). The latter sensitivity after 7+1th week of gestation is associated to a high specificity (100%), with an overall accuracy of 96% for foetal gender determination. This analysis demonstrates that foetal gender determination in maternal plasma is reliable after the 9th week of gestation and it can be used, in association with ultrasonography, for screening to determine the need for chorionic villus sampling for prenatal diagnosis of X-linked disorders, such as haemophilia. © 2011 Blackwell Publishing Ltd.

Geochronology and petrogenesis of MORB from the Juan de Fuca and Gorda ridges by 238U230Th disequilibrium

USGS Publications Warehouse

Goldstein, S.J.; Murrell, M.T.; Janecky, D.R.; Delaney, J.R.; Clague, D.A.

1991-01-01

A highly precise mass spectrometric method of analysis was used to determine 238U234U230Th232Th in axial and off-axis basalt glasses from Juan de Fuca (JDF) and Gorda ridges. Initial 230Th activity excesses in the axial samples range from 3 to 38%, but generally lie within a narrow range of 12 to 15%. Secondary alteration effects were evaluated using ??234U and appear to be negligible; hence the 230Th excesses are magmatic in origin. Direct dating of MORB was accomplished by measuring the decrease in excess 230Th in off-axis samples. 238U230Th ages progressively increase with distance from axis. Uncertainties in age range from 10 to 25 ka for UTh ages of 50 to 200 ka. The full spreading rate based on UTh ages for Endeavour segment of JDF is 5.9 ?? 1/2 cm/yr, with asymmetry in spreading between the Pacific (4.0 ?? 0.6 cm/yr) and JDF (1.9 ?? 0.6 cm/yr) plates. For northern Gorda ridge, the half spreading rate for the JDF plate is found to be 3.0 ?? 0.4 cm/yr. These rates are in agreement with paleomagnetic spreading rates and topographic constraints. This suggests that assumptions used to determine ages, including constancy of initial 230Th 232Th ratio over time, are generally valid for the areas studied. Samples located near the axis of spreading are typically younger than predicted by these spreading rates, which most likely reflects recent volcanism within a 1-3 km wide zone of crustal accretion. Initial 230Th/232Th ratios and 230Th activity were also used to examine the recent Th/U evolution and extent of melting of mantle sources beneath these ridges. A negative anomaly in 230Th 232Th for Axial seamount lavas provides the first geochemical evidence of a mantle plume source for Axial seamount and the Cobb-Eickelberg seamount chain and indicates recent depletion of other JDF segment sources. Large 230Th activity excesses for lavas from northern Gorda ridge and Endeavour segment indicate formation from a lower degree of partial melting than other segments. An inverse correlation between 230Th excess and 230Th 232Th for each ridge indicates that these lower degree melts formed from slightly less depleted sources than higher degree melts. Uniformity in 230Th excess for other segments suggests similarity in processes of melt formation and mixing beneath most of the JDF-Gorda ridge area. The average initial 230Th 232Th activity ratio of 1.31 for the JDF-Gorda ridge area is in agreement with the predicted value of 1.32 from the ThSr isotope mantle array. ?? 1991.

Constraining the thermal conditions of impact environments through integrated low-temperature thermochronometry and numerical modeling

NASA Astrophysics Data System (ADS)

Kelly, N. M.; Marchi, S.; Mojzsis, S. J.; Flowers, R. M.; Metcalf, J. R.; Bottke, W. F., Jr.

2017-12-01

Impacts have a significant physical and chemical influence on the surface conditions of a planet. The cratering record is used to understand a wide array of impact processes, such as the evolution of the impact flux through time. However, the relationship between impactor size and a resulting impact crater remains controversial (e.g., Bottke et al., 2016). Likewise, small variations in the impact velocity are known to significantly affect the thermal-mechanical disturbances in the aftermath of a collision. Development of more robust numerical models for impact cratering has implications for how we evaluate the disruptive capabilities of impact events, including the extent and duration of thermal anomalies, the volume of ejected material, and the resulting landscape of impacted environments. To address uncertainties in crater scaling relationships, we present an approach and methodology that integrates numerical modeling of the thermal evolution of terrestrial impact craters with low-temperature, (U-Th)/He thermochronometry. The approach uses time-temperature (t-T) paths of crust within an impact crater, generated from numerical simulations of an impact. These t-T paths are then used in forward models to predict the resetting behavior of (U-Th)/He ages in the mineral chronometers apatite and zircon. Differences between the predicted and measured (U-Th)/He ages from a modeled terrestrial impact crater can then be used to evaluate parameters in the original numerical simulations, and refine the crater scaling relationships. We expect our methodology to additionally inform our interpretation of impact products, such as lunar impact breccias and meteorites, providing robust constraints on their thermal histories. In addition, the method is ideal for sample return mission planning - robust "prediction" of ages we expect from a given impact environment enhances our ability to target sampling sites on the Moon, Mars or other solar system bodies where impacts have strongly shaped the surface. Bottke, W.F., Vokrouhlicky, D., Ghent, B., et al. (2016). 47th LPSC, Abstract #2036.

Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation

PubMed Central

Zhang, Song; Takaku, Motoki; Zou, Liyun; Gu, Ai-di; Chou, Wei-chun; Zhang, Ge; Wu, Bing; Kong, Qing; Thomas, Seddon Y.; Serody, Jonathan S.; Chen, Xian; Xu, Xiaojiang; Wade, Paul A.; Cook, Donald N.; Ting, Jenny P.; Wan, Yisong Y.

2017-01-01

Th17 cells are critically involved in host defense, inflammation, and autoimmunity1–5. TGF-β is instrumental in Th17 differentiation by cooperating with IL-66,7. Yet, the mechanism of how TGF-β enables Th17 differentiation remains elusive. Here we reveal that TGF-β licenses Th17 differentiation by releasing Ski-Smad4-complex suppressed RORγt expression. We found serendipitously that, unlike wild-type T cells, Smad4-deficient T cells differentiated into Th17 cells in the absence of TGF-β signaling in a RORγt-dependent manner. Ectopic Smad4 expression suppressed the RORγt expression and Th17 differentiation of Smad4-deficient T cells. Unexpectedly however, TGF-β neutralized Smad4 mediated suppression without affecting Smad4 binding to Rorc locus. Proteomic analysis revealed that Smad4 interacted with Ski, a transcriptional repressor degraded upon TGF-β stimulation. Ski controlled the histone acetylation/de-acetylation of Rorc locus and Th17 differentiation via Smad4 because ectopic Ski expression inhibited H3K9Ac of Rorc locus, Rorc expression and Th17 differentiation in a Smad4-dependent manner. Therefore, TGF-β-induced disruption of Ski releases Ski-Smad4 complex imposed suppression of RORγt to license Th17 differentiation. This study reveals a critical mechanism by which TGF-β controls Th17 differentiation and uncovers Ski-Smad4 axis as a potential therapeutic target for treating Th17 related diseases. PMID:29072299

Multiphase Complete Exchange: A Theoretical Analysis

DTIC Science & Technology

1993-08-01

Birkhiuser, Boston, 1984. 24 [9] C-T. Ho and M. T. Raghunath . Efficient communication primitives on hy- percubes. In Proc. 6th. DMCC, pages 390-397...1991. [10] C-T. Ho and M. T. Raghunath . Efficient communication primitives on hy- percubes. Technical Report RJ 7932 (72915), IBM, T. J. Watson Center

Pregnant Field Students' Guilt

ERIC Educational Resources Information Center

Baum, Nehami

2006-01-01

This study examined guilt feelings among social work students who were pregnant for the first time during field work training. Semi-structured interviews were conducted either in the 9th month (n=5) or 2-12 months after delivery (n=5). Content analysis revealed 6 main triggers, illustrated by excerpts, which stimulated field students' guilt…

National Gaming Council.

ERIC Educational Resources Information Center

House, Peter W.; And Others

This publication describes thirty-three simulation games discussed at the 9th Symposium of the Council in April of 1970. Those articles related to the social sciences are: 1) Teaching Economics with Competitive Games; 2) An Economic Strategy Analysis Game; 3) A Social Simulation Strategy for Researching the Israeli Arab Conflict; 4) The Use of…

Risk Factors for Suicide Ideation Among Adolescents: Five-Year National Data Analysis.

PubMed

Im, Yeojin; Oh, Won-Oak; Suk, Minhyun

2017-06-01

This study identified risk factors for suicide ideation among adolescents through a secondary analysis using data collected over five years from the 5th-9th Korea Youth Risk Behavior Survey. We analyzed 370,568 students' responses to questions about suicidality. The risk factors for suicide ideation included demographic characteristics, such as gender (girls), low grades, low economic status, and not living with one or both parents. Behavioral and mental health risk factors affecting suicide ideation were depression, low sleep satisfaction, high stress, alcohol consumption, smoking, and sexual activity. Health care providers should particularly target adolescents manifesting the above risk factors when developing suicide prevention programs for them. Copyright © 2017 Elsevier Inc. All rights reserved.

Numerical Analysis of a Single Microchannel Within a High-Temperature Hydrogen Heat Exchanger for Beamed Energy Propulsion Applications

DTIC Science & Technology

2013-07-01

was subtracted. Here, based on prospective tube shell materials such as carbon fiber reinforced carbon , an emissivity of .9 was chosen. The...Conference Paper 3. DATES COVERED (From - To) 14 Jul 2013 – 19 Jul 2013 4. TITLE AND SUBTITLE Numerical Analysis of a Single Microchannel Within a High ...energy to the spacecraft via microwaves . This work computationally models three different heat exchanger channel designs for use in a beam

Electroacupuncture to treat painful diabetic neuropathy: study protocol for a three-armed, randomized, controlled pilot trial.

PubMed

Lee, Seunghoon; Kim, Joo-Hee; Shin, Kyung-Min; Kim, Jung-Eun; Kim, Tae-Hun; Kang, Kyung-Won; Lee, Minhee; Jung, So-Young; Shin, Mi-Suk; Kim, Ae-Ran; Park, Hyo-Ju; Hong, Kwon-Eui; Choi, Sun-Mi

2013-07-18

The purpose of this study is to conduct a basic analysis of the effectiveness and safety of electroacupuncture in the treatment of painful diabetic neuropathy (PDN) as compared to placebo and usual care and to evaluate the feasibility of large-scale clinical research. This study is a protocol for a three-armed, randomized, patient-assessor-blinded (to the type of treatment), controlled pilot trial. Forty-five participants with a ≥ six month history of PDN and a mean weekly pain score of ≥ 4 on the 11-point Pain Intensity Numerical Rating Scale (PI-NRS) will be assigned to the electroacupuncture group (n = 15), sham group (n = 15) or usual care group (n = 15). The participants assigned to the electroacupuncture group will receive electroacupuncture (remaining for 30 minutes with a mixed current of 2 Hz/120 Hz and 80% of the bearable intensity) at 12 standard acupuncture points (bilateral ST36, GB39, SP9, SP6, LR3 and GB41) twice per week for eight weeks (a total of 16 sessions) as well as the usual care. The participants in the sham group will receive sham electroacupuncture (no electrical current will be passed to the needle, but the light will be seen, and the sound of the pulse generator will be heard by the participants) at non-acupuncture points as well as the usual care. The participants in the usual care group will not receive electroacupuncture treatment during the study period and will receive only the usual care. The follow-up will be in the 5th, 9th and 17th weeks after random allocation. The PI-NRS score assessed at the ninth week will be the primary outcome measurement used in this study. The Short-Form McGill Pain Questionnaire (SF-MPQ), a sleep disturbance score (11-point Likert scale), the Short-Form 36v2 Health Survey (SF-36), the Beck Depression Inventory (BDI) and the Patient Global Impression of Change (PGIC) will be used as outcome variables to evaluate the effectiveness of the acupuncture. Safety will be assessed at every visit. The result of this trial will provide a basis for the effectiveness and safety of electroacupuncture for PDN. Clinical Research information Service. Unique identifier: KCT0000466.

Electroacupuncture to treat painful diabetic neuropathy: study protocol for a three-armed, randomized, controlled pilot trial

PubMed Central

2013-01-01

Background The purpose of this study is to conduct a basic analysis of the effectiveness and safety of electroacupuncture in the treatment of painful diabetic neuropathy (PDN) as compared to placebo and usual care and to evaluate the feasibility of large-scale clinical research. Methods/design This study is a protocol for a three-armed, randomized, patient-assessor-blinded (to the type of treatment), controlled pilot trial. Forty-five participants with a ≥ six month history of PDN and a mean weekly pain score of ≥ 4 on the 11-point Pain Intensity Numerical Rating Scale (PI-NRS) will be assigned to the electroacupuncture group (n = 15), sham group (n = 15) or usual care group (n = 15). The participants assigned to the electroacupuncture group will receive electroacupuncture (remaining for 30 minutes with a mixed current of 2 Hz/120 Hz and 80% of the bearable intensity) at 12 standard acupuncture points (bilateral ST36, GB39, SP9, SP6, LR3 and GB41) twice per week for eight weeks (a total of 16 sessions) as well as the usual care. The participants in the sham group will receive sham electroacupuncture (no electrical current will be passed to the needle, but the light will be seen, and the sound of the pulse generator will be heard by the participants) at non-acupuncture points as well as the usual care. The participants in the usual care group will not receive electroacupuncture treatment during the study period and will receive only the usual care. The follow-up will be in the 5th, 9th and 17th weeks after random allocation. The PI-NRS score assessed at the ninth week will be the primary outcome measurement used in this study. The Short-Form McGill Pain Questionnaire (SF-MPQ), a sleep disturbance score (11-point Likert scale), the Short-Form 36v2 Health Survey (SF-36), the Beck Depression Inventory (BDI) and the Patient Global Impression of Change (PGIC) will be used as outcome variables to evaluate the effectiveness of the acupuncture. Safety will be assessed at every visit. Discussion The result of this trial will provide a basis for the effectiveness and safety of electroacupuncture for PDN. Trial registration Clinical Research information Service. Unique identifier: KCT0000466. PMID:23866906

Flexner 3.0-Democratization of Medical Knowledge for the 21st Century: Teaching Medical Science Using K-12 General Pathology as a Gateway Course.

PubMed

Weinstein, Ronald S; Krupinski, Elizabeth A; Weinstein, John B; Graham, Anna R; Barker, Gail P; Erps, Kristine A; Holtrust, Angelette L; Holcomb, Michael J

2016-01-01

A medical school general pathology course has been reformatted into a K-12 general pathology course. This new course has been implemented at a series of 7 to 12 grade levels and the student outcomes compared. Typically, topics covered mirrored those in a medical school general pathology course serving as an introduction to the mechanisms of diseases. Assessment of student performance was based on their score on a multiple-choice final examination modeled after an examination given to medical students. Two Tucson area schools, in a charter school network, participated in the study. Statistical analysis of examination performances showed that there were no significant differences as a function of school ( F = 0.258, P = .6128), with students at school A having an average test scores of 87.03 (standard deviation = 8.99) and school B 86.00 (standard deviation = 8.18; F = 0.258, P = .6128). Analysis of variance was also conducted on the test scores as a function of gender and class grade. There were no significant differences as a function of gender ( F = 0.608, P = .4382), with females having an average score of 87.18 (standard deviation = 7.24) and males 85.61 (standard deviation = 9.85). There were also no significant differences as a function of grade level ( F = 0.627, P = .6003), with 7th graders having an average of 85.10 (standard deviation = 8.90), 8th graders 86.00 (standard deviation = 9.95), 9th graders 89.67 (standard deviation = 5.52), and 12th graders 86.90 (standard deviation = 7.52). The results demonstrated that middle and upper school students performed equally well in K-12 general pathology. Student course evaluations showed that the course met the student's expectations. One class voted K-12 general pathology their "elective course-of-the-year."

Flexner 3.0—Democratization of Medical Knowledge for the 21st Century

PubMed Central

Krupinski, Elizabeth A.; Weinstein, John B.; Graham, Anna R.; Barker, Gail P.; Erps, Kristine A.; Holtrust, Angelette L.; Holcomb, Michael J.

2016-01-01

A medical school general pathology course has been reformatted into a K-12 general pathology course. This new course has been implemented at a series of 7 to 12 grade levels and the student outcomes compared. Typically, topics covered mirrored those in a medical school general pathology course serving as an introduction to the mechanisms of diseases. Assessment of student performance was based on their score on a multiple-choice final examination modeled after an examination given to medical students. Two Tucson area schools, in a charter school network, participated in the study. Statistical analysis of examination performances showed that there were no significant differences as a function of school (F = 0.258, P = .6128), with students at school A having an average test scores of 87.03 (standard deviation = 8.99) and school B 86.00 (standard deviation = 8.18; F = 0.258, P = .6128). Analysis of variance was also conducted on the test scores as a function of gender and class grade. There were no significant differences as a function of gender (F = 0.608, P = .4382), with females having an average score of 87.18 (standard deviation = 7.24) and males 85.61 (standard deviation = 9.85). There were also no significant differences as a function of grade level (F = 0.627, P = .6003), with 7th graders having an average of 85.10 (standard deviation = 8.90), 8th graders 86.00 (standard deviation = 9.95), 9th graders 89.67 (standard deviation = 5.52), and 12th graders 86.90 (standard deviation = 7.52). The results demonstrated that middle and upper school students performed equally well in K-12 general pathology. Student course evaluations showed that the course met the student’s expectations. One class voted K-12 general pathology their “elective course-of-the-year.” PMID:28725762

THE COMMUNITY RESOURCES POOL SEMINAR DESCRIPTIONS.

ERIC Educational Resources Information Center

SATURDAY MORNING SEMINARS FOR ELEMENTARY AND SECONDARY SCHOOL STUDENTS WERE CONDUCTED WITH PROFESSIONAL RESOURCE PERSONS AS TEACHERS. THE PROGRAM WAS VOLUNTARY. THREE 9-WEEK SEMINARS WERE CONDUCTED IN THE FALL. SUBJECTS STUDIED WERE MICROBIOLOGY AND ZOOLOGY (6TH GRADE), COMPUTER MATH (7TH AND 8TH GRADE), AND CHEMISTRY (GRADES 9-12). DURING THE…

75 FR 67753 - Agency Information Collection Activities: Haitian Hemispheric Opportunity Through Partnership...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-03

... Rulings, Office of International Trade, 799 9th Street, NW., 5th Floor, Washington, DC 20229-1177. FOR.... Customs and Border Protection, Regulations and Rulings, Office of International Trade, 799 9th Street, NW... to extend additional trade benefits to Haiti. This trade program, the Haitian Hemispheric Opportunity...

The Electromyographic Threshold in Girls and Women.

PubMed

Long, Devon; Dotan, Raffy; Pitt, Brynlynn; McKinlay, Brandon; O'Brien, Thomas D; Tokuno, Craig; Falk, Bareket

2017-02-01

The electromyographic threshold (EMG Th ) is thought to reflect increased high-threshold/type-II motor-unit (MU) recruitment and was shown higher in boys than in men. Women differ from men in muscular function. Establish whether females' EMG Th and girls-women differences are different than males'. Nineteen women (22.9 ± 3.3yrs) and 20 girls (10.3 ± 1.1yrs) had surface EMG recorded from the right and left vastus lateralis muscles during ramped cycle-ergometry to exhaustion. EMG root-mean-squares were averaged per pedal revolution. EMG Th was determined as the least residual sum of squares for any two regression-line data divisions, if the trace rose ≥ 3SD above its regression line. EMG Th was expressed as % final power-output (%Pmax) and %VO 2 pk power (%P VO2pk ). EMG Th was detected in 13 (68%) of women, but only 9 (45%) of girls (p < .005) and tended to be higher in the girls (%Pmax= 88.6 ± 7.0 vs. 83.0 ± 6.9%, p = .080; %P VO2pk = (101.6 ± 17.6 vs. 90.6 ± 7.8%, p = .063). When EMG Th was undetected it was assumed to occur at 100%Pmax or beyond. Consequently, EMG Th values turned significantly higher in girls than in women (94.8 ± 7.4 vs. 88.4 ± 9.9%Pmax, p = .026; and 103.2 ± 11.7 vs. 95.2 ± 9.9%P VO2pk , p = .028). During progressive exercise, girls appear to rely less on higher-threshold/type-II MUs than do women, suggesting differential muscle activation strategy.

Analysis of Plane-Parallel Electron Beam Propagation in Different Media by Numerical Simulation Methods

NASA Astrophysics Data System (ADS)

Miloichikova, I. A.; Bespalov, V. I.; Krasnykh, A. A.; Stuchebrov, S. G.; Cherepennikov, Yu. M.; Dusaev, R. R.

2018-04-01

Simulation by the Monte Carlo method is widely used to calculate the character of ionizing radiation interaction with substance. A wide variety of programs based on the given method allows users to choose the most suitable package for solving computational problems. In turn, it is important to know exactly restrictions of numerical systems to avoid gross errors. Results of estimation of the feasibility of application of the program PCLab (Computer Laboratory, version 9.9) for numerical simulation of the electron energy distribution absorbed in beryllium, aluminum, gold, and water for industrial, research, and clinical beams are presented. The data obtained using programs ITS and Geant4 being the most popular software packages for solving the given problems and the program PCLab are presented in the graphic form. A comparison and an analysis of the results obtained demonstrate the feasibility of application of the program PCLab for simulation of the absorbed energy distribution and dose of electrons in various materials for energies in the range 1-20 MeV.

78 FR 36034 - Citizens Coinage Advisory Committee; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

.... Time: 9:30 a.m. to 2:30 p.m. Location: Conference Room A, United States Mint, 801 9th Street NW... the CCAC; 801 9th Street NW.; Washington, DC 20220; or call 202-354-7200. Any member of the public...

78 FR 59426 - Citizens Coinage Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-26

.... Time: 9:30 a.m. to 1:30 p.m. Location: Conference Room A, United States Mint, 801 9th Street NW... the CCAC; 801 9th Street NW.; Washington, DC 20220; or call 202-354-7200. Any member of the public...

Guanine nucleotide-binding protein α subunit hypofunction in children with short stature and disproportionate shortening of the 4th and 5th metacarpals.

PubMed

Inta, Ioana Monica; Choukair, Daniela; Bender, Sebastian; Kneppo, Carolin; Knauer-Fischer, Sabine; Meyenburg, Kahina; Ivandic, Boris; Pfister, Stefan M; Bettendorf, Markus

2014-01-01

GNAS encodes the α subunit of the stimulatory G protein (Gsα). Maternal inherited Gsα mutations cause pseudohypoparathyroidism type Ia (PHP-Ia), associated with shortening of the 4th and 5th metacarpals. Here we investigated the Gsα pathway in short patients with distinct shortening of the 4th and 5th metacarpals. In 571 children with short stature and 4 patients with PHP-Ia metacarpal bone lengths were measured. In identified patients we analysed the Gsα protein function in platelets, performed GNAS sequencing, and epigenetic analysis of four significant differentially methylated regions. In 51 patients (8.9%) shortening of the 4th and 5th metacarpals was more pronounced than their height deficit. No GNAS coding mutations were identified in 20 analysed patients, except in 2 PHP-Ia patients. Gsα activity was reduced in all PHP-Ia patients and in 25% of the analysed patients. No significant methylation changes were identified. Our findings suggest that patients with short stature and distinct metacarpal bone shortening could be part of the wide variety of PHP/PPHP, therefore it was worthwhile analysing the Gsα protein function and GNAS gene in these patients in order to further elucidate the phenotype and genotype of Gsα dysfunction.

MedlinePlus Connect

MedlinePlus

... code requests: Problems/Diagnoses • ICD-9-CM (International Classification of Disease, 9 th edition, Clinical Modification) • ICD-10-CM (International Classification of Disease, 10 th edition, Clinical Modification) • SNOMED ...

A genome-wide association meta-analysis identifies new childhood obesity loci

PubMed Central

Bradfield, Jonathan P.; Taal, H. Rob; Timpson, Nicholas J.; Scherag, André; Lecoeur, Cecile; Warrington, Nicole M.; Hypponen, Elina; Holst, Claus; Valcarcel, Beatriz; Thiering, Elisabeth; Salem, Rany M.; Schumacher, Fredrick R.; Cousminer, Diana L.; Sleiman, Patrick M.A.; Zhao, Jianhua; Berkowitz, Robert I.; Vimaleswaran, Karani S.; Jarick, Ivonne; Pennell, Craig E.; Evans, David M.; St. Pourcain, Beate; Berry, Diane J.; Mook-Kanamori, Dennis O; Hofman, Albert; Rivadeinera, Fernando; Uitterlinden, André G.; van Duijn, Cornelia M.; van der Valk, Ralf J.P.; de Jongste, Johan C.; Postma, Dirkje S.; Boomsma, Dorret I.; Gauderman, William J.; Hassanein, Mohamed T.; Lindgren, Cecilia M.; Mägi, Reedik; Boreham, Colin A.G.; Neville, Charlotte E.; Moreno, Luis A.; Elliott, Paul; Pouta, Anneli; Hartikainen, Anna-Liisa; Li, Mingyao; Raitakari, Olli; Lehtimäki, Terho; Eriksson, Johan G.; Palotie, Aarno; Dallongeville, Jean; Das, Shikta; Deloukas, Panos; McMahon, George; Ring, Susan M.; Kemp, John P.; Buxton, Jessica L.; Blakemore, Alexandra I.F.; Bustamante, Mariona; Guxens, Mònica; Hirschhorn, Joel N.; Gillman, Matthew W.; Kreiner-Møller, Eskil; Bisgaard, Hans; Gilliland, Frank D.; Heinrich, Joachim; Wheeler, Eleanor; Barroso, Inês; O'Rahilly, Stephen; Meirhaeghe, Aline; Sørensen, Thorkild I.A.; Power, Chris; Palmer, Lyle J.; Hinney, Anke; Widen, Elisabeth; Farooqi, I. Sadaf; McCarthy, Mark I.; Froguel, Philippe; Meyre, David; Hebebrand, Johannes; Jarvelin, Marjo-Riitta; Jaddoe, Vincent W.V.; Smith, George Davey; Hakonarson, Hakon; Grant, Struan F.A.

2012-01-01

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made to establish genetic influences on common early-onset obesity. We performed a North American-Australian-European collaborative meta-analysis of fourteen studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight novel signals yielding association with P < 5×10−6 in to nine independent datasets (n = 2,818 cases and 4,083 controls) we observed two loci that yielded a genome wide significant combined P-value, namely near OLFM4 on 13q14 (rs9568856; P=1.82×10−9; OR=1.22) and within HOXB5 on 17q21 (rs9299; P=3.54×10−9; OR=1.14). Both loci continued to show association when including two extreme childhood obesity cohorts (n = 2,214 cases and 2,674 controls). Finally, these two loci yielded directionally consistent associations in the GIANT meta-analysis of adult BMI1. PMID:22484627

MHD natural convection and entropy generation in an open cavity having different horizontal porous blocks saturated with a ferrofluid

NASA Astrophysics Data System (ADS)

Gibanov, Nikita S.; Sheremet, Mikhail A.; Oztop, Hakan F.; Al-Salem, Khaled

2018-04-01

In this study, natural convection combined with entropy generation of Fe3O4-water nanofluid within a square open cavity filled with two different porous blocks under the influence of uniform horizontal magnetic field is numerically studied. Porous blocks of different thermal properties, permeability and porosity are located on the bottom wall. The bottom wall of the cavity is kept at hot temperature Th, while upper open boundary is at constant cold temperature Tc and other walls of the cavity are supposed to be adiabatic. Governing equations with corresponding boundary conditions formulated in dimensionless stream function and vorticity using Brinkman-extended Darcy model for porous blocks have been solved numerically using finite difference method. Numerical analysis has been carried out for wide ranges of Hartmann number, nanoparticles volume fraction and length of the porous blocks. It has been found that an addition of spherical ferric oxide nanoparticles can order the flow structures inside the cavity.

Analysis of Indonesian educational system standard with KSIM cross-impact method

NASA Astrophysics Data System (ADS)

Arridjal, F.; Aldila, D.; Bustamam, A.

2017-07-01

The Result of The Programme of International Student Assessment (PISA) on 2012 shows that Indonesia is on 64'th position from 65 countries in Mathematics Mean Score. The 2013 Learning Curve Mapping, Indonesia is included in the 10th category of countries with the lowest performance on cognitive skills aspect, i.e. 37'th position from 40 countries. Competency is built by 3 aspects, one of them is cognitive aspect. The low result of mapping on cognitive aspect, describe the low of graduate competences as an output of Indonesia National Education System (INES). INES adopting a concept Eight Educational System Standards (EESS), one of them is graduate competency standard which connected directly with Indonesia's students. This research aims is to model INES by using KSIM cross-impact. Linear regression models of EESS constructed using the accreditation national data of Senior High Schools in Indonesia. The results then interpreted as impact value on the construction of KSIM cross-impact INES. The construction is used to analyze the interaction of EESS and doing numerical simulation for possible public policy in the education sector, i.e. stimulate the growth of education staff standard, content, process and infrastructure. All simulations of public policy has been done with 2 methods i.e with a multiplier impact method and with constant intervention method. From numerical simulation result, it is shown that stimulate the growth standard of content in the construction KSIM cross-impact EESS is the best option for public policy to maximize the growth of graduate competency standard.

Interleukin-4 and interleukin-13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression.

PubMed

Wise, Sarah K; Laury, Adrienne M; Katz, Elizabeth H; Den Beste, Kyle A; Parkos, Charles A; Nusrat, Asma

2014-05-01

Altered expression of epithelial intercellular junction proteins has been observed in sinonasal biopsies from nasal polyps and epithelial layers cultured from nasal polyp patients. These alterations comprise a "leaky" epithelial barrier phenotype. We hypothesize that T helper 2 (Th2) cytokines interleukin (IL)-4 and IL-13 modulate epithelial junction proteins, thereby contributing to the leaky epithelial barrier. Differentiated primary sinonasal epithelial layers cultured at the air-liquid interface were exposed to IL-4, IL-13, and controls for 24 hours at 37°C. Epithelial resistance measurements were taken every 4 hours during cytokine exposure. Western blot and immunofluorescence staining/confocal microscopy were used to assess changes in a panel of tight and adherens junction proteins. Western blot densitometry was quantified with image analysis. IL-4 and IL-13 exposure resulted in a mean decrease in transepithelial resistance at 24 hours to 51.6% (n = 6) and 68.6% (n = 8) of baseline, respectively. Tight junction protein junctional adhesion molecule-A (JAM-A) expression decreased 42.2% with IL-4 exposure (n = 9) and 37.5% with IL-13 exposure (n = 9). Adherens junction protein E-cadherin expression decreased 35.3% with IL-4 exposure (n = 9) and 32.9% with IL-13 exposure (n = 9). Tight junction protein claudin-2 showed more variability but had a trend toward higher expression with Th2 cytokine exposure. There were no appreciable changes in claudin-1, occludin, or zonula occludens-1 (ZO-1) with IL-4 or IL-13 exposure. Sinonasal epithelial exposure to Th2 cytokines IL-4 and IL-13 results in alterations in intercellular junction proteins, reflecting increased epithelial permeability. Such changes may explain some of the phenotypic manifestations of Th2-mediated sinonasal disease, such as edema, nasal discharge, and environmental reactivity. © 2014 ARS-AAOA, LLC.

International Workshop on Finite Elements for Microwave Engineering (11th) - FEM2012 Student Support Grants

DTIC Science & Technology

2015-05-22

Liu 4.4. Optical, Electromagnetics, and Thermal Modeling of Interaction of a Focused Beam of Light with Plasmonic Nanoparticles Eren S. Unlu and...Kursat Sendur* 11:50 Lunch break (MacGregor Room) 13:10 3.4. Transient Thermal Analysis using a Non-conformal Domain Decomposition Approach Yang...Coffee break (Pinion room) 10:10 Session 9: Advances in Hybrid Methods and Multiphysics Problems (B. Shanker, L. Kempel) 9.2. Thermal -Aware DC IR

Pyloric localisation in 57 dogs of breeds susceptible to gastric dilatation-volvulus in the UK using computed tomography.

PubMed

Tomlinson, A W; Lillis, S M; German, A J; Burrow, R D

2016-12-17

Describe the location of the pylorus using CT in dog breeds susceptible to gastric dilatation-volvulus in the UK. Descriptive anatomical study. Abdominal CT scans of 57 client-owned dogs were reviewed to assess pyloric position relative to the 9th, 10th, 11th and 13th ribs and 2 and 3 cm caudal to the 13th rib at the 8, 9 and 10 o'clock positions. The angle of the pylorus from the centre of the abdominal cavity relative to the sagittal plane was also determined. In 88 per cent of cases, the pylorus was located in the right cranioventral abdomen with 63 per cent positioned at the 9-10 o'clock position. The overall distance between the pylorus and right abdominal wall (RAW) at the 13th rib 10 o'clock position was equivalent to 29 per cent of ventral abdominal length, significantly greater than the median overall distance of ∼14 per cent of ventral abdominal length between the pylorus and RAW at the 9th or 10th rib 10 o'clock position (P<0.0001). Common gastropexy locations may result in considerable displacement of the pylorus relative to its natural anatomic location. Further case-control studies are required to assess the clinical significance of this finding. British Veterinary Association.

78 FR 14154 - Citizens Coinage Advisory Committee; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-04

..., 2013. Time: 9:30 a.m. to 5:00 p.m. Location: Conference Room A, United States Mint, 801 9th Street NW... the CCAC; 801 9th Street NW; Washington, DC 20220; or call 202-354-7200. Any member of the public...

The Constraint Method for Solid Finite Elements.

DTIC Science & Technology

1980-09-30

9. ’Hierarchical Approximation in Finite Element Analysis", by I. Norman Katz, International Symposium on Innovative Numerical Analysis In Applied ... Engineering Science, Versailles, France, May 23-27, 1977. 10. "Efficient Generation of Hierarchal Finite Elamnts Through the Use of Precomputed Arrays

U/Th dating by SHRIMP RG ion-microprobe mass spectrometry using single ion-exchange beads

NASA Astrophysics Data System (ADS)

Bischoff, James L.; Wooden, Joe; Murphy, Fred; Williams, Ross W.

2005-04-01

We present a new analytical method for U-series isotopes using the SHRIMP RG (Sensitive High mass Resolution Ion MicroProbe) mass spectrometer that utilizes the preconcentration of the U-series isotopes from a sample onto a single ion-exchange bead. Ion-microprobe mass spectrometry is capable of producing Th ionization efficiencies in excess of 2%. Analytical precision is typically better than alpha spectroscopy, but not as good as thermal ionization mass spectroscopy (TIMS) and inductively coupled plasma multicollector mass spectrometry (ICP-MS). Like TIMS and ICP-MS the method allows analysis of small samples sizes, but also adds the advantage of rapidity of analysis. A major advantage of ion-microprobe analysis is that U and Th isotopes are analyzed in the same bead, simplifying the process of chemical separation. Analytical time on the instrument is ˜60 min per sample, and a single instrument-loading can accommodate 15-20 samples to be analyzed in a 24-h day. An additional advantage is that the method allows multiple reanalyses of the same bead and that samples can be archived for reanalysis at a later time. Because the ion beam excavates a pit only a few μm deep, the mount can later be repolished and reanalyzed numerous times. The method described of preconcentrating a low concentration sample onto a small conductive substrate to allow ion-microprobe mass spectrometry is potentially applicable to many other systems.

U/Th dating by SHRIMP RG ion-microprobe mass spectrometry using single ion-exchange beads

USGS Publications Warehouse

Bischoff, J.L.; Wooden, J.; Murphy, F.; Williams, Ross W.

2005-01-01

We present a new analytical method for U-series isotopes using the SHRIMP RG (Sensitive High mass Resolution Ion MicroProbe) mass spectrometer that utilizes the preconcentration of the U-series isotopes from a sample onto a single ion-exchange bead. Ion-microprobe mass spectrometry is capable of producing Th ionization efficiencies in excess of 2%. Analytical precision is typically better than alpha spectroscopy, but not as good as thermal ionization mass spectroscopy (TIMS) and inductively coupled plasma multicollector mass spectrometry (ICP-MS). Like TIMS and ICP-MS the method allows analysis of small samples sizes, but also adds the advantage of rapidity of analysis. A major advantage of ion-microprobe analysis is that U and Th isotopes are analyzed in the same bead, simplifying the process of chemical separation. Analytical time on the instrument is ???60 min per sample, and a single instrument-loading can accommodate 15-20 samples to be analyzed in a 24-h day. An additional advantage is that the method allows multiple reanalyses of the same bead and that samples can be archived for reanalysis at a later time. Because the ion beam excavates a pit only a few ??m deep, the mount can later be repolished and reanalyzed numerous times. The method described of preconcentrating a low concentration sample onto a small conductive substrate to allow ion-microprobe mass spectrometry is potentially applicable to many other systems. Copyright ?? 2005 Elsevier Ltd.

The cross-cultural adaptation of the DASH questionnaire in Thai (DASH-TH).

PubMed

Tongprasert, Siam; Rapipong, Jeeranan; Buntragulpoontawee, Montana

2014-01-01

Clinical measurement. Currently there are no self-report questionnaires in Thai to evaluate disability levels in patients suffering from upper extremity musculoskeletal disorders. To translate and cross-cultural adaptation the disabilities of the arm, shoulder and hand (DASH) questionnaire to Thai version and to evaluate content validity, construct validity and internal consistency of the questionnaire. The DASH-TH was produced by following cross-cultural adaptation guidelines stated by the Institute for Work and Health (IWH). Forty Thai patients with arm, shoulder or hand problems participated in field testing of the questionnaire. Content validity was determined by obtaining the item-objective congruence (IOC) value for each questionnaire item. Correlation between the DASH-TH score and numeric rating scale was used to assess construct validity. Internal consistency of DASH-TH was measured using Cronbach's alpha coefficient. Forty patients (14 males, 26 females) with arm, shoulder or hand problems enrolled in the present study. The average age of patients was 44.8 years. The index of item-objective congruence (IOC) of each item ranged from 0.7 to 1.0. The Cronbach's alpha coefficient of the questionnaire was 0.938. There was no correlation between DASH-TH score and numeric rating scale. The DASH-TH has high content validity and internal consistency. N/A. Copyright © 2014 Hanley & Belfus. Published by Elsevier Inc. All rights reserved.

A Summative Program Evaluation of a Comprehensive 9th Grade Transition Program

ERIC Educational Resources Information Center

Roybal, Victoria M.

2011-01-01

The transition from 8th grade to 9th grade is one that is replete with challenges for students, especially for minority students who live in economically disadvantaged communities. One low-income, high minority comprehensive high school in the western United States implemented five separate strategies to create a freshman transition program to aid…

Environmental 238U and 232Th concentration measurements in an area of high level natural background radiation at Palong, Johor, Malaysia.

PubMed

Ramli, A Termizi; Hussein, A Wahab M A; Wood, A Khalik

2005-01-01

Concentrations of uranium-238 and thorium-232 in soil, water, grass, moss and oil-palm fruit samples collected from an area of high background radiation were determined using neutron activation analysis (NAA). U-238 concentration in soil ranged from 4.9 mg kg(-1) (58.8 Bq kg(-1)) to 40.4 mg kg(-1) (484.8 Bq kg(-1)), Th-232 concentration ranged from 14.9 mg kg(-1) (59.6 Bq kg(-1)) to 301.0 mg kg(-1) (1204 Bq kg(-1)). The concentration of U-238 in grass samples ranged from below the detection limit to 0.076 mg kg(-1) (912 mBq kg(-1)), and Th-232 ranged from 0.008 mg kg(-1) (32 mBq kg(-1)) to 0.343 mg kg(-1) (1.372 Bq kg(-1)). U-238 content in water samples ranged from 0.33 mg kg(-1) (4.0 Bq L(-1)) to 1.40 mg kg(-1) (16.8 Bq L(-1)), and Th-232 ranged from 0.19 mg kg(-1) (0.76 Bq L(-1)) to 0.66 mg kg(-1) (2.64 Bq L(-1)). It can be said that the concentrations of environmental U-238 and Th-232 in grass and water samples in the study area are insignificant. Mosses were found to be possible bio-radiological indicators due to their high absorption of the heavy radioelements from the environment.

Comprehensive Occupational Data Analysis Programs 80 (CODAP80) User’s Manual.

DTIC Science & Technology

1984-01-01

8217 -____ ____ ___ - -- -- -~--- - PA"m: 84/006a 5, -(,0 i 4. TH IkdmS. lbne ISCOMlPREHENS IVE OCCUPATIONAL DATA ANALYSIS PROGRAMS 80 (CODAP80) JAUARY 1984 User s Manua 7. Auw...AD-A144 125 COMPEHIENSIVE OCCUPATIONAL DATA ANALYSIS PROGRAMS 80 ’i (CODAP8OI USES MANUAtfUD NAVY OCCUPATIONAL DEVELOPMENT AND ANALYSIS CENTER...e COMPREVENSIVE OCCUPATIONAL DATA ANALYSIS PROGRAMS 80 (CODAP80) JANUARY 1984Uer s Manual 7. Author(s) L. pt, t wis ONapetion ft.p No. N/A 9

45 CFR Appendix A to Part 1356 - NYTD Data Elements

Code of Federal Regulations, 2011 CFR

2011-10-01

...-31) 5 Sex Male Female 6 Race—American Indian or Alaska Native Yes All youth in served, baseline and... Adjudicated delinquent Yes No 18 Education level Less than 6th grade Served population only. 6th grade 7th grade 8th grade 9th grade 10th grade 11th grade 12th grade Postsecondary education or training College...

45 CFR Appendix A to Part 1356 - NYTD Data Elements

Code of Federal Regulations, 2010 CFR

2010-10-01

...-31) 5 Sex Male Female 6 Race—American Indian or Alaska Native Yes All youth in served, baseline and... Adjudicated delinquent Yes No 18 Education level Less than 6th grade Served population only. 6th grade 7th grade 8th grade 9th grade 10th grade 11th grade 12th grade Postsecondary education or training College...

Effects of overweight and obesity on motor and mental development in infants and toddlers.

PubMed

Cataldo, R; Huang, J; Calixte, R; Wong, A T; Bianchi-Hayes, J; Pati, S

2016-10-01

A consequence of childhood obesity may be poor developmental outcomes. This study aimed to examine the relationship between weight and developmental delays in young children. We conducted a secondary analysis of the Early Childhood Longitudinal Study Birth Cohort data. Logistic regression models quantified the association between different weight statuses (normal weight <85th, overweight ≥90th, obese ≥95th percentile for weight) and delays in motor and mental development. Children classified as overweight in both waves had higher percentages of delays in wave 2 (motor [7.5 vs. 6.2-6.4%], mental [8.6 vs. 5.9-6.7%]), as well as wave 1 and/or wave 2 (motor [14.8 vs. 10.9-13.0%], mental [11.9 vs. 9.0-10.1%]), compared with other children. This association was also found in children who were obese at both time points in wave 2 (motor delay [8.9 vs. 4.9-7.3%], mental delay [10.3 vs. 6.0-7.2%]), as well as wave 1 and/or wave 2 (motor delay [14.5 vs. 10.9-12.9%], mental delay [14.1 vs. 9.4-10.1%]). In the adjusted models, children classified as always obese were more likely to have a mental delay in wave 2 (adjusted odds ratio [aOR] 1.89, 95% confidence interval [CI]: 1.21-2.95) as well as wave 1 and/or wave 2 (aOR 1.56, 95% CI: 1.08-2.26). These children were also more likely to have motor delay (aOR 1.47, 95% CI: 1.02-2.13) in wave 1 and/or wave 2. Overweight children are more likely than their normal-weight peers to have motor and mental developmental delays. Preventing obesity during infancy may facilitate reducing developmental delays in young children. © 2015 World Obesity.

75 FR 32817 - National Endowment for the Arts; Arts Advisory Panel

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-09

... meeting, from 9 a.m. to 6 p.m. on July 8th and from 9 a.m. to 3 p.m. on July 9th, will be closed. Music... 22nd, and from 9 a.m. to 3 p.m. on July 23rd, will be closed. Music (application review): July 27-30...

Reproducing an Early-20th-Century Wave Machine

ERIC Educational Resources Information Center

Daffron, John A.; Greenslade, Thomas B., Jr.

2016-01-01

Physics students often have problems understanding waves. Over the years numerous mechanical devices have been devised to show the propagation of both transverse and longitudinal waves (Ref. 1). In this article an updated version of an early-20th-century transverse wave machine is discussed. The original, Fig. 1, is at Creighton University in…

Strategic Interventions

ERIC Educational Resources Information Center

Deshler, Donald D.; Tollefson, Julie M.

2006-01-01

Despite numerous successes achieved by American schools in recent years, one of the remaining challenges is the large number of adolescents who lack basic literacy skills. Nearly 25 percent of 8th and 12th graders score below the basic level in reading on the National Assessment of Educational Progress and only 70 percent of all high school…

CPR - infant

MedlinePlus

... Hill M, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 9th ed. Philadelphia, PA: Elsevier; ... Hill M, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 9th ed. Philadelphia, PA: Elsevier; ...

Wood stains

MedlinePlus

... RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 9th ed. Philadelphia, PA: Elsevier; ... RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 9th ed. Philadelphia, PA: Elsevier; ...

Aftershave poisoning

MedlinePlus

... RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 9th ed. Philadelphia, PA: Elsevier; ... RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 9th ed. Philadelphia, PA: Elsevier; ...

NUMERICAL STUDY OF ELECTROMAGNETIC WAVES GENERATED BY A PROTOTYPE DIELECTRIC LOGGING TOOL

EPA Science Inventory

To understand the electromagnetic waves generated by a prototype dielectric logging tool, a
numerical study was conducted using both the finite-difference, time-domain method and a frequency- wavenumber method. When the propagation velocity in the borehole was greater than th...

Proceedings of the Army Numerical Analysis Conference (11th) Held at Frankford Arsenal, Philadelphia, Pa., on 13-14 February 1974

DTIC Science & Technology

1974-12-01

incineration of chemical agent mustard and pesticides are presented. 1. EDGEWOOD ARSENAL INCINERATION PROGRAM The name of the program which we...only 5 elements to a compound read. -This was fine for mustard, but had to be altered when we wished to simulate the incineration of a nerve agent VX...input data to this program. A process flow sheet of the scrubber system is shown in Figure 1. The incinerator burns Mustard Agent . The off gas from

[Why does our heart fibrillate?- or what goats can teach us].

PubMed

Eckstein, Jens

2014-07-23

Our present knowledge about cardiac electrophysiology is based on numerous experiments and discoveries going back to the Greek antique and ancient Egypt. Exploration of cardiac anatomy was followed by the description of circulation and cardiac physiology in the 17th century. In the early 20th century cardiac electrophysiology became the new field of interest and was studied with the help of numerous animal experiments (squid, rays, dogs, goats, mice and other species). We ought to be grateful for the knowledge and possibilities in modern medicine that were made possible by the great number of researchers, patients and animals that contributed to this.

Highlights from the 37th Annual Meeting of the American Society of Clinical Oncology, San Francisco, USA, 12–15 May 2001

PubMed Central

Lohrisch, Caroline

2001-01-01

Key issues discussed at the breast cancer sessions of the 37th American Society of Clinical Oncology (ASCO) meeting, 2001, included the following: breast cancer in the elderly; toxicity; updates on HER2 and use of trastuzumab (anti-HER2) in metastatic disease; and several early reports on novel therapeutic strategies. As was stated by numerous speakers both at this and other meetings, and as demonstrated by several abstracts, the use of predictive factors appears to be the most effective way to enhance the efficacy of numerous therapies, both target specific and nonspecific.

The crystal chemistry of four thorium sulfates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albrecht, Amanda J.; Sigmon, Ginger E.; Moore-Shay, Laura

2011-07-15

Four thorium sulfate compounds have been synthesized and characterized. [Th(SO{sub 4}){sub 2}(H{sub 2}O){sub 7}].2H{sub 2}O (ThS1) crystallizes in space group P2{sub 1}/m, a=7.2488(4), b=12.1798(7), c=8.0625(5) A, {beta}=98.245(1){sup o}; Na{sub 10}[Th{sub 2}(SO{sub 4}){sub 9}(H{sub 2}O){sub 2}].3H{sub 2}O (ThS2), Pna2{sub 1}, a=17.842(2), b=6.9317(8), c=27.550(3) A; Na{sub 2}[Th{sub 2}(SO{sub 4}){sub 5}(H{sub 2}O){sub 3}].H{sub 2}O (ThS3), C2/c, a=16.639(2), b=9.081(1), c=25.078(3) A, {beta}= 95.322(2){sup o}; [Th{sub 4}(SO{sub 4}){sub 7}(OH){sub 2}(H{sub 2}O){sub 6}].2H{sub 2}O (ThS4), Pnma, a=18.2127(9), b=11.1669(5), c=14.4705(7) A. In all cases the Th cations are coordinated by nine O atoms corresponding to SO{sub 4} tetrahedra, OH groups, and H{sub 2}O groups. The structural unitmore » of ThS1 is an isolated cluster consisting of a single Th polyhedron with two monodentate SO{sub 4} tetrahedra and seven H{sub 2}O groups. A double-wide Th sulfate chain is the basis of ThS2. The structures of ThS3 and ThS4 are frameworks of Th polyhedra and sulfate tetrahedra, and each contains channels that extend through the framework. One of the Th cations in ThS3 is coordinated by a bidentate SO{sub 4} tetrahedron, and ThS4 is unusual in the presence of a pair of Th cations that share a polyhedral face. - Graphical abstract: The structures of four hydrous thorium sulfates are reported that have structural units consisting of finite clusters, chains, and frameworks. Highlights: > Four hydrous thorium sulfates have structural units consisting of finite clusters, chains, and frameworks. > In each the Th cations are coordinated by nine O atoms from SO{sub 4} tetrahedra, OH groups, and H{sub 2}O groups. > The details of the linkages of ThO{sub 9} polyhedra and sulfate tetrahedra vary considerably in these structures.« less

CCR6+ Th cell distribution differentiates systemic lupus erythematosus patients based on anti-dsDNA antibody status.

PubMed

Zhong, Wei; Jiang, Zhenyu; Wu, Jiang; Jiang, Yanfang; Zhao, Ling

2018-01-01

Systemic lupus erythematosus (SLE) disease has been shown to be associated with the generation of multiple auto-antibodies. Among these, anti-dsDNA antibodies (anti-DNAs) are specific and play a pathogenic role in SLE. Indeed, anti-DNA + SLE patients display a worse disease course. The generation of these pathogenic anti-DNAs has been attributed to the interaction between aberrant T helper (Th) cells and autoimmune B cells. Thus, in this study we have investigated whether CCR6 + Th cells have the ability to differentiate SLE patients based on anti-DNA status, and if their distribution has any correlation with disease activity. We recruited 25 anti-DNA + and 25 anti-DNA - treatment-naive onset SLE patients, matched for various clinical characteristics in our nested matched case-control study. CCR6 + Th cells and their additional subsets were analyzed in each patient by flow cytometry. Anti-DNA + SLE patients specifically had a higher percentage of Th cells expressing CCR6 and CXCR3. Further analysis of CCR6 + Th cell subsets showed that anti-DNA + SLE patients had elevated proportions of Th9, Th17, Th17.1 and CCR4/CXCR3 double-negative (DN) cells. However, the proportions of CCR6 - Th subsets, including Th1 and Th2 cells, did not show any association with anti-DNA status. Finally, we identified a correlation between CCR6 + Th subsets and clinical indicators, specifically in anti-DNA + SLE patients. Our data indicated that CCR6 + Th cells and their subsets were elevated and correlated with disease activity in anti-DNA + SLE patients. We speculated that CCR6 + Th cells may contribute to distinct disease severity in anti-DNA + SLE patients.

Climate Change, Risks and Natural Resources didactic issues of educational content geography of Bulgaria and the world in 9th and 10th grade

NASA Astrophysics Data System (ADS)

Dermendzhieva, Stela; Nejdet, Semra

2017-03-01

The purpose of this paper is to follow "Climate change, risks and Natural Resources" in the curriculum of Geography of Bulgaria and the world in 9th and 10th grade and to interpret some didactic aspects. Analysis of key themes, concepts and categories related to the environment, events and approaches to environmental protection and the environmentally sound development of sectors of the economy is didikticheski targeted. Considering the emergence and development of geo-ecological issues, their scope and their importance to the environment, systematize some species and some approaches to solving them. Geography education in grade 9 and 10 involves acquiring knowledge, developing skills and composing behaviors of objective perception and assessment of the reality of globed, regional and local aspect. The emerging consumer and individualistic culture snowballing globalization, are increasingly occurring global warming, declining biodiversity form new realities which education must respond appropriately. The objective, consistency, accessibility and relevance in real terms are meaningful, logical accents. Whether and how reproduced in the study of Geography of Bulgaria and the world is the subject of research study in this report. Geoecological structuring of topics, concepts and categories can be done in different signs. In terms of their scope are local, national or regional, and global. Matter and interdisciplinary approach, which is to reveal the unity of the "man-society-nature" to clarify the complexity of their character with a view to forming a harmonious personality with high Geoecological consciousness and culture, and the activities carried out in their study.

Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study.

PubMed

Miyashita, Masako; Kikuya, Masahiro; Yamanaka, Chizuru; Ishikuro, Mami; Obara, Taku; Sato, Yuki; Metoki, Hirohito; Nakaya, Naoki; Nagami, Fuji; Tomita, Hiroaki; Kiyomoto, Hideyasu; Sugawara, Junichi; Hozawa, Atsushi; Fuse, Nobuo; Suzuki, Yoichi; Tsuji, Ichiro; Kure, Shigeo; Yaegashi, Nobuo; Yamamoto, Masayuki; Kuriyama, Shinichi

2015-12-01

After the Great East Japan Earthquake of 2011, there has been a concern about health problems among children. Therefore, we investigated the prevalence of wheeze and eczema symptoms and associated factors among children in areas primarily affected by the disaster. From 2012 to 2014, we distributed the parent-administered questionnaire to 25,198 children in all 233 public schools in the 13 municipalities of Miyagi Prefecture in northeast Japan. A total of 7,155 responses (mean age 10.5 ± 2.2 years) were received (response rate: 28.4%). The prevalence of allergic symptoms according to the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire in 2nd, 4th, 6th, and 8th graders was 12.4%, 9.9%, 9.3%, and 5.6% for wheeze, and 20.1%, 18.0%, 14.0%, and 12.4% for eczema. In multivariate logistic analysis, younger age, history of hospitalization, and difficulties in children's daily lives as assessed by the Strengths and Difficulties Questionnaire (SDQ), were significantly and consistently associated with both allergic symptoms (both P < 0.05). Living in a coastal municipality was also associated with eczema symptoms (P = 0.0278). The prevalence of eczema symptoms in the 2nd (20.1%) and 8th (12.4%) grades was significantly higher than previously reported in Japan. Living in a coastal municipality was independently associated with eczema symptoms, and psychometric properties were also closely linked to allergic symptoms. These findings are clinically important for understanding the risks of allergic disorders after natural disasters.

Diseases Transmitted by Man's Worst Friend: the Rat.

PubMed

Fox, James G

2015-12-01

Historically, the rat has been considered a scourge to mankind, for example, rats infected with the plague bacillus that caused the Black Death, which accounted for millions of deaths in Europe during the Middle Ages. At least three pandemics (in the 5th and 6th, 8th through 14th, and 19th through 21st centuries) of plague ravaged civilizations, and the disease undoubtedly plagued humankind prior to recorded history. Also, numerous other diseases are spread to humans by rats; thus, a quote from Hans Zinsser's text Rats, Lice, and History, "Man and rat will always be pitted against each other as implacable enemies," conveys the general revulsion that society holds for the wild rat.

A dose schedule for intraarticular steroids in juvenile arthritis.

PubMed

Eberhard, B Anne; Ilowite, Norman T; Sison, Cristina

2012-02-01

To determine whether the intraarticular (IA) dose of triamcinolone hexacetonide (TH) or triamcinolone acetonide (TA) influences time to relapse among patients with juvenile idiopathic arthritis (JIA). The primary endpoint variable was the time to relapse of arthritis in the affected joint after an intraarticular (IA) injection. A relapse was defined as the reoccurrence of active arthritis in the injected joint. Analysis was carried out including only the first IA joint injection for each patient. Further analysis was conducted including the first knee injection alone. A separate analysis within the IA corticosteroid groups was performed using the Spearman rank coefficient, to determine if dose of IA steroid affected time to relapse. Records from 186 patients with JIA (145 females, 41 males) injected with either TH or TA were collected from January 1995 through December 2003. All subjects were followed for a minimum of 15 months from the time of IA injection. Of the 794 joint injections, 422 (53.1%) were injected with TH and 372 (46.9%) with TA. There were 111 first joint injections (all joints) with TH and 70 with TA. There were 89 first joint injections (knee only) with TH and 56 with TA. TH proved more effective than TA with respect to the time to relapse for first injection into all joints (10.47 ± 0.42 mo vs 8.66 ± 0.59 mo; p < 0.001), and for first injections into knee only (11.04 ± 0.44 vs 8.99 ± 0.65 mo; p < 0.001). IA doses ranged from 0.4 to 4 mg/kg (mean 1.56 ± 0.76) for TH and from 0.5 to 8 mg/kg (mean 2.54 ± 1.74) for TA. There was no correlation between time to relapse and dose of either TH and TA (r = 0.1, p > 0.5). There was no correlation between time to relapse and sex, duration of illness, age of patient, concurrent medications, or subtype of JIA. In a larger dataset (794 injections) we have confirmed our previous findings (227 injections) that TH is a more effective IA corticosteroid than TA. In this much larger data analysis, dose of IA corticosteroid in the range we studied did not significantly influence the duration of response.

Actes des Journees de linguistique (Proceedings of the Linguistics Conference) (9th, 1995).

ERIC Educational Resources Information Center

Audette, Julie, Ed.; And Others

Papers (entirely in French) presented at the conference on linguistics include these topics: language used in the legislature of New Brunswick; cohesion in the text of Arabic-speaking language learners; automatic adverb recognition; logic of machine translation in teaching revision; expansion in physics texts; discourse analysis and the syntax of…

Y2K and International Agricultural Transportation: Analysis of Export Markets, Import Suppliers, and Major Food Aid Recipient Countries

DOT National Transportation Integrated Search

1999-09-01

USDA Y2K information assessment of international food transportation modes in : selected foreign countries. The assessment targeted 9 of the top 10 markets for : U.S. Agricultural exports and 7 of the top 8 suppliers of imported food products : to th...

6th Annual Earth System Grid Federation Face to Face Conference Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, D. N.

The Sixth Annual Face-to-Face (F2F) Conference of the Earth System Grid Federation (ESGF), a global consortium of international government agencies, institutions, and companies dedicated to the creation, management, analysis, and distribution of extreme-scale scientific data, was held December 5–9, 2016, in Washington, D.C.

Multilevel Analysis of Student Civics Knowledge Scores

ERIC Educational Resources Information Center

Gregory, Chris; Miyazaki, Yasuo

2018-01-01

Compositional effects of scholarly culture classroom/school climate on civic knowledge scores of 9th graders in the United States were examined using the International Association for the Evaluation of Educational Achievement (IEA) 1999 Civic Education Study data. Following Evans et al. (2010, 2014), we conceived that the number of books at home,…

Analysis of Mount St. Helens ash from optical photoelectric photometry

NASA Technical Reports Server (NTRS)

Cardelli, J. A.; Ackerman, T. P.

1983-01-01

The optical properties of suspended dust particles from the eruption of Mt. St. Helens on July 23, 1980 are investigated using photoelectric observations of standard stars obtained on the 0.76-m telescope at the University of Washington 48 hours after the eruption. Measurements were made with five broad-band filters centered at 3910, 5085, 5480, 6330, and 8050 A on stars of varying color and over a wide range of air masses. Anomalous extinction effects due to the volcanic ash were detected, and a significant change in the wavelength-dependent extinction parameter during the course of the observations was established by statistical analysis. Mean particle size (a) and column density (N) are estimated using the Mie theory, assuming a log-normal particle-size distribution: a = 0.18 micron throughout; N = 1.02 x 10 to the 9th/sq cm before 7:00 UT and 2.33 x 10 to the 9th/sq cm after 8:30 UT on July 25, 1980. The extinction is attributed to low-level, slowly migrating ash, possibly combined with products of gas-to-particle conversion and coagulation.

45 CFR Appendix A to Part 1356 - NYTD Data Elements

Code of Federal Regulations, 2012 CFR

2012-10-01

...) DD= day (01-31) 5 Sex Male Female 6 Race—American Indian or Alaska Native Yes All youth in served... Yes No 17 Adjudicated delinquent Yes No 18 Education level Less than 6th grade Served population only. 6th grade 7th grade 8th grade 9th grade 10th grade 11th grade 12th grade Postsecondary education or...

45 CFR Appendix A to Part 1356 - NYTD Data Elements

Code of Federal Regulations, 2013 CFR

2013-10-01

...) DD= day (01-31) 5 Sex Male Female 6 Race—American Indian or Alaska Native Yes All youth in served... Yes No 17 Adjudicated delinquent Yes No 18 Education level Less than 6th grade Served population only. 6th grade 7th grade 8th grade 9th grade 10th grade 11th grade 12th grade Postsecondary education or...

45 CFR Appendix A to Part 1356 - NYTD Data Elements

Code of Federal Regulations, 2014 CFR

2014-10-01

...) DD= day (01-31) 5 Sex Male Female 6 Race—American Indian or Alaska Native Yes All youth in served... Yes No 17 Adjudicated delinquent Yes No 18 Education level Less than 6th grade Served population only. 6th grade 7th grade 8th grade 9th grade 10th grade 11th grade 12th grade Postsecondary education or...

Heimlich maneuver on self

MedlinePlus

... RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; ... RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; ...

Lomotil overdose

MedlinePlus

... RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 9th ed. Philadelphia, PA: ... RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 9th ed. Philadelphia, PA: ...

Harmonic cavities and the transverse mode-coupling instability driven by a resistive wall

DOE Office of Scientific and Technical Information (OSTI.GOV)

Venturini, M.

The effect of rf harmonic cavities on the transverse mode-coupling instability (TMCI) is still not very well understood. We offer a fresh perspective on the problem by proposing a new numerical method for mode analysis and investigating a regime of potential interest to the new generation of light sources where resistive wall is the dominant source of transverse impedance. When the harmonic cavities are tuned for maximum flattening of the bunch profile we demonstrate that at vanishing chromaticities the transverse single-bunch motion is unstable at any current, with growth rate that in the relevant range scales as the 6th powermore » of the current. With these assumptions and radiation damping included, we find that for machine parameters typical of 4th-generation light sources the presence of harmonic cavities could reduce the instability current threshold by more than a factor two.« less

Harmonic cavities and the transverse mode-coupling instability driven by a resistive wall

DOE PAGES

Venturini, M.

2018-02-01

The effect of rf harmonic cavities on the transverse mode-coupling instability (TMCI) is still not very well understood. We offer a fresh perspective on the problem by proposing a new numerical method for mode analysis and investigating a regime of potential interest to the new generation of light sources where resistive wall is the dominant source of transverse impedance. When the harmonic cavities are tuned for maximum flattening of the bunch profile we demonstrate that at vanishing chromaticities the transverse single-bunch motion is unstable at any current, with growth rate that in the relevant range scales as the 6th powermore » of the current. With these assumptions and radiation damping included, we find that for machine parameters typical of 4th-generation light sources the presence of harmonic cavities could reduce the instability current threshold by more than a factor two.« less

Workshop on Models for Plasma Spectroscopy

NASA Astrophysics Data System (ADS)

1993-09-01

A meeting was held at St. Johns College, Oxford from Monday 27th to Thursday 30th of September 1993 to bring together a group of physicists working on computational modelling of plasma spectroscopy. The group came from the UK, France, Israel and the USA. The meeting was organized by myself, Dr. Steven Rose of RAL and Dr. R.W. Lee of LLNL. It was funded by the U.S. European Office of Aerospace Research and Development and by LLNL. The meeting grew out of a wish by a group of core participants to make available to practicing plasma physicists (particularly those engaged in the design and analysis of experiments) sophisticated numerical models of plasma physics. Additional plasma physicists attended the meeting in Oxford by invitation. These were experimentalists and users of plasma physics simulation codes whose input to the meeting was to advise the core group as to what was really needed.

Harmonic cavities and the transverse mode-coupling instability driven by a resistive wall

NASA Astrophysics Data System (ADS)

Venturini, M.

2018-02-01

The effect of rf harmonic cavities on the transverse mode-coupling instability (TMCI) is still not very well understood. We offer a fresh perspective on the problem by proposing a new numerical method for mode analysis and investigating a regime of potential interest to the new generation of light sources where resistive wall is the dominant source of transverse impedance. When the harmonic cavities are tuned for maximum flattening of the bunch profile we demonstrate that at vanishing chromaticities the transverse single-bunch motion is unstable at any current, with growth rate that in the relevant range scales as the 6th power of the current. With these assumptions and radiation damping included, we find that for machine parameters typical of 4th-generation light sources the presence of harmonic cavities could reduce the instability current threshold by more than a factor two.

Energy Systems - Present, Future: Extra Terrestrials, Grades 7, 8, 9,/Science.

ERIC Educational Resources Information Center

National Science Teachers Association, Washington, DC.

The 12 lessons presented in this guide are structured so that they may be integrated into science lessons in 7th-, 8th-, or 9th-grades. Suggestions are made for extension of study. Lessons are approached through classroom role-playing of outer space visitors who seek to understand energy conversion principles used on Earth. Major emphasis is…

English as a Foreign Language Spelling Development: A Longitudinal Study

ERIC Educational Resources Information Center

Kahn-Horwitz, Janina; Sparks, Richard L.; Goldstein, Zahava

2012-01-01

English as a foreign language (EFL) spelling was examined longitudinally three times (4th, 9th, 12th grades) during 9 years of EFL study among Hebrew first language (L1) students. The study examined the impact of L1 literacy variables including phonemic awareness, word attack, and spelling on EFL spelling and the relationship between EFL literacy…

Systematic monitoring of male circumcision scale-up in Nyanza, Kenya: exploratory factor analysis of service quality instrument and performance ranking.

PubMed

Omondi Aduda, Dickens S; Ouma, Collins; Onyango, Rosebella; Onyango, Mathews; Bertrand, Jane

2014-01-01

Considerable conceptual and operational complexities related to service quality measurements and variability in delivery contexts of scaled-up medical male circumcision, pose real challenges to monitoring implementation of quality and safety. Clarifying latent factors of the quality instruments can enhance contextual applicability and the likelihood that observed service outcomes are appropriately assessed. To explore factors underlying SYMMACS service quality assessment tool (adopted from the WHO VMMC quality toolkit) and; determine service quality performance using composite quality index derived from the latent factors. Using a comparative process evaluation of Voluntary Medical Male Circumcision Scale-Up in Kenya site level data was collected among health facilities providing VMMC over two years. Systematic Monitoring of the Medical Male Circumcision Scale-Up quality instrument was used to assess availability of guidelines, supplies and equipment, infection control, and continuity of care services. Exploratory factor analysis was performed to clarify quality structure. Fifty four items and 246 responses were analyzed. Based on Eigenvalue >1.00 cut-off, factors 1, 2 & 3 were retained each respectively having eigenvalues of 5.78; 4.29; 2.99. These cumulatively accounted for 29.1% of the total variance (12.9%; 9.5%; 6.7%) with final communality estimates being 13.06. Using a cut-off factor loading value of ≥0.4, fifteen items loading on factor 1, five on factor 2 and one on factor 3 were retained. Factor 1 closely relates to preparedness to deliver safe male circumcisions while factor two depicts skilled task performance and compliance with protocols. Of the 28 facilities, 32% attained between 90th and 95th percentile (excellent); 45% between 50th and 75th percentiles (average) and 14.3% below 25th percentile (poor). the service quality assessment instrument may be simplified to have nearly 20 items that relate more closely to service outcomes. Ranking of facilities and circumcision procedure using a composite index based on these items indicates that majority performed above average.

Salivary proteomics in lichen planus: A relationship with pathogenesis?

PubMed

Souza, M M; Florezi, G P; Nico, Mms; de Paula, F; Paula, F M; Lourenço, S V

2018-01-30

Oral lichen planus is a chronic, T-cell-mediated, inflammatory disease that affects the oral cavity. The oral lichen planus pathogenesis is still unclear, however, the main evidence is that the mechanisms of activation of different T lymphocyte pathway induce apoptosis with an increase in Th1 and Th17 subtypes cells, triggered by the release of cytokines. This study analysed saliva proteomics to identify protein markers that might be involved in the pathogenesis and development of the disease. Proteins differentially expressed by oral lichen planus and healthy controls were screened using mass spectrometry; the proteins found in oral lichen planus were subjected to bioinformatics analysis, including gene ontology and string networks analysis. The multiplex analysis validation allowed the correlation between the proteins identified and the involved cytokines in Th17 response. One hundred and eight proteins were identified in oral lichen planus, of which 17 proteins showed a high interaction between them and indicated an association with the disease. Expression of these proteins was correlated with the triggering of cytokines, more specifically the Th17 cells. Proteins, such as S100A8, S100A9, haptoglobin, can trigger cytokines and might be associated with a pathological function and antioxidant activities in oral lichen planus. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.

Development of peptide-containing nerves in the human fetal prostate gland.

PubMed Central

Jen, P Y; Dixon, J S

1995-01-01

Immunohistochemical methods were used to study the developing peptidergic innervation of the human fetal prostate gland in a series of specimens ranging in gestational age from 13 to 30 wk. The overall innervation of each specimen was visualised using protein gene product 9.5 (PGP), a general nerve marker. The onset and development of specific neuropeptide-containing subpopulations were investigated using antisera to neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP), bombesin (BOM), somatostatin (SOM), leu-enkephalin (l-ENK) and met-enkephalin (m-ENK). In addition the occurrence and distribution of presumptive noradrenergic nerves was studied using antisera to dopamine-beta-hydroxylase (D beta H) and tyrosine hydroxylase (TH). At 13 wk numerous branching PGP-immunoreactive (-IR) nerves were observed in the capsule of the developing prostate gland and surrounding the preprostatic urethra but the remainder of the gland was devoid of nerves. The majority of nerves in the capsule contained D beta H and TH and were presumed to be noradrenergic in type while other nerves (in decreasing numbers) contained NPY, l-ENK, SP and CGRP. Nerves associated with the preprostatic urethra did not contain any of the neuropeptides under investigation. At 17 wk the density of nerves in the capsule had increased and occasional m-ENK-, VIP- and BOM-IR nerve fibres were also observed. In addition PGP, D beta H-, TH-, NPY- and l-ENK-IR nerves occurred in association with smooth muscle bundles which at 17 wk were present in the outer part of the gland. Occasional PGP-IR nerves were also present at the base of the epithelium forming some of the prostatic glands. At 23 wk some of the subepithelial nerves showed immunoreactivity for NPY, VIP or l-ENK. At 26 wk smooth muscle bundles occurred throughout the gland and were richly innervated by PGP, D beta H and TH-IR nerves while a less dense plexus was formed by NPY- and l-ENK-IR nerves together with a few m-ENK-IR nerves. Occasional smooth muscle-associated varicose nerve fibres showed immunoreactivity for SP, CGRP, VIP or BOM although the majority of these types of nerve formed perivascular plexuses. Also at 26 wk numerous varicose nerve fibres were observed in association with the prostatic acini, the majority of such nerves containing NPY with a few showing immunoreactivity to VIP, l-ENK, SP or CGRP.(ABSTRACT TRUNCATED AT 400 WORDS) Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10 Fig. 11 Fig. 12 Fig. 13 PMID:7591978

Mangiferin attenuates TH1/TH2 cytokine imbalance in an ovalbumin-induced asthmatic mouse model.

PubMed

Guo, Hong-Wei; Yun, Chen-Xia; Hou, Guang-Han; Du, Jun; Huang, Xin; Lu, Yi; Keller, Evan T; Zhang, Jian; Deng, Jia-Gang

2014-01-01

Mangiferin is a major bioactive ingredient in Mangifera indica Linn. (Anacardiaceae) leaves. Aqueous extract of such leaves have been used as an indigenous remedy for respiratory diseases like asthma and coughing in traditional Chinese medicine. However, underlying molecular mechanisms of mangiferin on anti-asthma remain unclear. In our present study, we investigated the anti-asthmatic effect of mangiferin on Th1/Th2 cytokine profiles and explored its underlying immunoregulatory mechanism in mouse model of allergic asthma. Mangiferin significantly reduced the total inflammatory cell counts and eosinophil infiltration, decreased the production of ovalbumin-specific IgE in serum and PGD2 in BALF. The antibody array analysis showed that mangiferin down-regulated the levels of one group of cytokines/chemokines including Th2-related IL-4, IL-5, IL-13, and others IL-3, IL-9, IL-17, RANTES, TNF-α, but simultaneously up-regulated Th1-related IFN-γ, IL-2 and IL-10 and IL-12 expression in serum. Thus it attenuates the imbalance of Th1/Th2 cells ratio by diminishing the abnormal mRNA levels of Th1 cytokines (IFN-γ and IL-12) and Th2 cytokines (IL-4, IL-5 and IL-13). Finally, mangiferin substantially inhibited the activation and expression of STAT-6 and GATA-3 in excised lung tissues. Our results suggest that mangiferin can exert anti-asthmatic effect. The underlying mechanism may attribute to the modulation of Th1/Th2 cytokine imbalance via inhibiting the STAT6 signaling pathway.

Mangiferin Attenuates Th1/Th2 Cytokine Imbalance in an Ovalbumin-Induced Asthmatic Mouse Model

PubMed Central

Hou, Guang-Han; Du, Jun; Huang, Xin; Lu, Yi; Keller, Evan T.; Zhang, Jian; Deng, Jia-Gang

2014-01-01

Mangiferin is a major bioactive ingredient in Mangifera indica Linn. (Anacardiaceae) leaves. Aqueous extract of such leaves have been used as an indigenous remedy for respiratory diseases like asthma and coughing in traditional Chinese medicine. However, underlying molecular mechanisms of mangiferin on anti-asthma remain unclear. In our present study, we investigated the anti-asthmatic effect of mangiferin on Th1/Th2 cytokine profiles and explored its underlying immunoregulatory mechanism in mouse model of allergic asthma. Mangiferin significantly reduced the total inflammatory cell counts and eosinophil infiltration, decreased the production of ovalbumin-specific IgE in serum and PGD2 in BALF. The antibody array analysis showed that mangiferin down-regulated the levels of one group of cytokines/chemokines including Th2-related IL-4, IL-5, IL-13, and others IL-3, IL-9, IL-17, RANTES, TNF-α, but simultaneously up-regulated Th1-related IFN-γ, IL-2 and IL-10 and IL-12 expression in serum. Thus it attenuates the imbalance of Th1/Th2 cells ratio by diminishing the abnormal mRNA levels of Th1 cytokines (IFN-γ and IL-12) and Th2 cytokines (IL-4, IL-5 and IL-13). Finally, mangiferin substantially inhibited the activation and expression of STAT-6 and GATA-3 in excised lung tissues. Our results suggest that mangiferin can exert anti-asthmatic effect. The underlying mechanism may attribute to the modulation of Th1/Th2 cytokine imbalance via inhibiting the STAT6 signaling pathway. PMID:24955743

Soil type influences the sensitivity of nutrient dynamics to changes in atmospheric CO2

USDA-ARS?s Scientific Manuscript database

Numerous studies have indicated that increases in atmospheric CO2 have the potential to decrease nitrogen availability through the process of progressive nitrogen limitation (PNL). The timing and magnitude of PNL in field experiments is varied due to numerous ecosystem processes. Here we examined th...

Victories are not Enough: Limitations of the German Way of War

DTIC Science & Technology

2005-12-01

the development of Germany as a nation and German military thought in the 19th century . It examines the origins of modern German military thinking and...separated the various principalities in the first half of the 19th century were so numerous that Germany seemed more of a dream for dreamers, for...the mid- 19th century until 1945, and its role in the unification of Germany is essential to understanding the German way of war. Prussian military

Network analysis of the Íslendinga sögur - the Sagas of Icelanders

NASA Astrophysics Data System (ADS)

Mac Carron, P.; Kenna, R.

2013-10-01

The Íslendinga sögur - or Sagas of Icelanders - constitute a collection of medieval literature set in Iceland around the late 9th to early 11th centuries, the so-called Saga Age. They purport to describe events during the period around the settlement of Iceland and the generations immediately following and constitute an important element of world literature thanks to their unique narrative style. Although their historicity is a matter of scholarly debate, the narratives contain interwoven and overlapping plots involving thousands of characters and interactions between them. Here we perform a network analysis of the Íslendinga sögur in an attempt to gather quantitative information on interrelationships between characters and to compare saga society to other social networks.

The InterFrost benchmark of Thermo-Hydraulic codes for cold regions hydrology - first inter-comparison results

NASA Astrophysics Data System (ADS)

Grenier, Christophe; Roux, Nicolas; Anbergen, Hauke; Collier, Nathaniel; Costard, Francois; Ferrry, Michel; Frampton, Andrew; Frederick, Jennifer; Holmen, Johan; Jost, Anne; Kokh, Samuel; Kurylyk, Barret; McKenzie, Jeffrey; Molson, John; Orgogozo, Laurent; Rivière, Agnès; Rühaak, Wolfram; Selroos, Jan-Olof; Therrien, René; Vidstrand, Patrik

2015-04-01

The impacts of climate change in boreal regions has received considerable attention recently due to the warming trends that have been experienced in recent decades and are expected to intensify in the future. Large portions of these regions, corresponding to permafrost areas, are covered by water bodies (lakes, rivers) that interact with the surrounding permafrost. For example, the thermal state of the surrounding soil influences the energy and water budget of the surface water bodies. Also, these water bodies generate taliks (unfrozen zones below) that disturb the thermal regimes of permafrost and may play a key role in the context of climate change. Recent field studies and modeling exercises indicate that a fully coupled 2D or 3D Thermo-Hydraulic (TH) approach is required to understand and model the past and future evolution of landscapes, rivers, lakes and associated groundwater systems in a changing climate. However, there is presently a paucity of 3D numerical studies of permafrost thaw and associated hydrological changes, and the lack of study can be partly attributed to the difficulty in verifying multi-dimensional results produced by numerical models. Numerical approaches can only be validated against analytical solutions for a purely thermic 1D equation with phase change (e.g. Neumann, Lunardini). When it comes to the coupled TH system (coupling two highly non-linear equations), the only possible approach is to compare the results from different codes to provided test cases and/or to have controlled experiments for validation. Such inter-code comparisons can propel discussions to try to improve code performances. A benchmark exercise was initialized in 2014 with a kick-off meeting in Paris in November. Participants from USA, Canada, Germany, Sweden and France convened, representing altogether 13 simulation codes. The benchmark exercises consist of several test cases inspired by existing literature (e.g. McKenzie et al., 2007) as well as new ones. They range from simpler, purely thermal cases (benchmark T1) to more complex, coupled 2D TH cases (benchmarks TH1, TH2, and TH3). Some experimental cases conducted in cold room complement the validation approach. A web site hosted by LSCE (Laboratoire des Sciences du Climat et de l'Environnement) is an interaction platform for the participants and hosts the test cases database at the following address: https://wiki.lsce.ipsl.fr/interfrost. The results of the first stage of the benchmark exercise will be presented. We will mainly focus on the inter-comparison of participant results for the coupled cases (TH1, TH2 & TH3). Further perspectives of the exercise will also be presented. Extensions to more complex physical conditions (e.g. unsaturated conditions and geometrical deformations) are contemplated. In addition, 1D vertical cases of interest to the Climate Modeling community will be proposed. Keywords: Permafrost; Numerical modeling; River-soil interaction; Arctic systems; soil freeze-thaw

The Role of Father Involvement and Marital Satisfaction in the Development of Family Interactive Abilities: A Multilevel Approach.

PubMed

Simonelli, Alessandra; Parolin, Micol; Sacchi, Chiara; De Palo, Francesca; Vieno, Alessio

2016-01-01

The study aims to investigate the development of family interactions from pregnancy to preschool age in a longitudinal perspective, using multilevel analysis. Also, it explored the impact of couple relationship and father involvement in childcare on the developmental trend of the quality of mother-father-child interactions. One hundred and three primiparous families were assessed at 7th month of pregnancy, 4th, 9th, and 18th months of child's life and during preschool age (36-48th), using the observational procedure named, Lausanne Trilogue Play. Parents' perception of marital satisfaction was assessed with the Dyadic Adjustment Scale at each point of measure; moreover, in the postnatal assessment, parents completed the Father Involvement Questionnaire. Results showed that family interactions increase over time. Secondly, a decrease of marital adjustment is associated with an improvement of the quality of family interactions. Moreover, father involvement predicts the quality of family interactions from the earliest stages of child's life. In a longitudinal perspective, family interactions and marital quality show opposite developmental trends and father's involvement represents a particularly important feature of the family.

An embedded formula of the Chebyshev collocation method for stiff problems

NASA Astrophysics Data System (ADS)

Piao, Xiangfan; Bu, Sunyoung; Kim, Dojin; Kim, Philsu

2017-12-01

In this study, we have developed an embedded formula of the Chebyshev collocation method for stiff problems, based on the zeros of the generalized Chebyshev polynomials. A new strategy for the embedded formula, using a pair of methods to estimate the local truncation error, as performed in traditional embedded Runge-Kutta schemes, is proposed. The method is performed in such a way that not only the stability region of the embedded formula can be widened, but by allowing the usage of larger time step sizes, the total computational costs can also be reduced. In terms of concrete convergence and stability analysis, the constructed algorithm turns out to have an 8th order convergence and it exhibits A-stability. Through several numerical experimental results, we have demonstrated that the proposed method is numerically more efficient, compared to several existing implicit methods.

[INFLUENCE OF TITANIUM COATING ON THE BIOCOMPATIBILITY OF POLYPROPYLENE IMPLANTS].

PubMed

Babichenko, I I; Kazantsev, A A; Titarov, D L; Shemyatovsky, K A; Ghevondian, N M; Melchenko, D; Alekhin, A I

2016-01-01

Comparative analysis of the proliferative activity of inflammatory cells and distribution of collagen types I and III was carried out around the net materials of polypropylene and titanium coating polypropylene using im- munohistochemical method and polarization microscopy. Experimental modeling of implanted mesh material were made in the soft tissues of the lumbar region of rats. On the 7th postoperative day, quantitative analysis of proliferating cells delected using antibodies to the Ki-67 protein showed, a significant decrease (p < 0.001) in the number of proliferating cells around the network elements of the polypropylene (29.1 ± 5.7 %), when com- pared to similar figures of infiltrates in titanium coating polypropylene (33.6 ± 3.1 %). Similar patterns were found on the 30th day of the experiment--15.9 ± 4.3 and 26.9 ± 3.6%--respectively (p < 0.001). Different types of collagen fibers in the granulomas around various types of implanted mesh material were detected on sections stained with Sirius red at polarizing light. On the 7th day after surgery, the ratio of collagen fibers ty- pe I and III in granulomas around the mesh material made of polypropylene was 1.085 ± 0.022 and this rati around materials of titanium coated polypropylene was higher--1.107 ± 0.013 (p = 0.017). On the 30th posto- perative day in the interface area ratio I/III collagen significantly increased and amounted to 1.174 ± 0.036 and 1.246 ± 0.102, respectively (p = 0.045). Assessing the impact of the use of titanium as a coating on the po- lypropylene, it can be argued that it promotes the formation of collagen I type and a more mature connective tis- sue around the mesh of the implants.

Count on dopamine: influences of COMT polymorphisms on numerical cognition

PubMed Central

Júlio-Costa, Annelise; Antunes, Andressa M.; Lopes-Silva, Júlia B.; Moreira, Bárbara C.; Vianna, Gabrielle S.; Wood, Guilherme; Carvalho, Maria R. S.; Haase, Vitor G.

2013-01-01

Catechol-O-methyltransferase (COMT) is an enzyme that is particularly important for the metabolism of dopamine. Functional polymorphisms of COMT have been implicated in working memory and numerical cognition. This is an exploratory study that aims at investigating associations between COMT polymorphisms, working memory, and numerical cognition. Elementary school children from 2th to 6th grades were divided into two groups according to their COMT val158met polymorphism [homozygous for valine allele (n = 61) vs. heterozygous plus methionine homozygous children or met+ group (n = 94)]. Both groups were matched for age and intelligence. Working memory was assessed through digit span and Corsi blocks. Symbolic numerical processing was assessed through transcoding and single-digit word problem tasks. Non-symbolic magnitude comparison and estimation tasks were used to assess number sense. Between-group differences were found in symbolic and non-symbolic numerical tasks, but not in working memory tasks. Children in the met+ group showed better performance in all numerical tasks while val homozygous children presented slower development of non-symbolic magnitude representations. These results suggest COMT-related dopaminergic modulation may be related not only to working memory, as found in previous studies, but also to the development of magnitude processing and magnitude representations. PMID:23966969

Thermus arciformis sp. nov., a thermophilic species from a geothermal area.

PubMed

Zhang, Xin-Qi; Ying, Yi; Ye, Ying; Xu, Xue-Wei; Zhu, Xu-Fen; Wu, Min

2010-04-01

Two aerobic, Gram-negative, non-motile, non-sporulating, yellow-pigmented bacteria, strains TH92(T) and TH91, were isolated from a hot spring located in Laibin, Guangxi, in the south-eastern geothermal area of China. The isolates grew at 40-77 degrees C (optimally at 70 degrees C) and at pH 6.0-9.5 (optimally at pH 7.5-8.0). Phylogenetic analysis of 16S rRNA gene sequences and levels of DNA-DNA relatedness together indicated that the new isolates represented a novel species of the genus Thermus with closest affinity to Thermus aquaticus, Thermus igniterrae and Thermus thermophilus. Compared with their closest relatives, strains TH92( T) and TH91 were able to assimilate a wider range of carbohydrates, amino acids and organic acids as sole carbon sources for growth, such as lactose and melibiose. The new isolates had lower combined levels of C(16 : 0 ) and iso-C(16 : 0) compared with their closest relatives. On the basis of polyphasic taxonomic characterization, strains TH92(T) and TH91 are considered to represent a single novel species of the genus Thermus, for which the name Thermus arciformis sp. nov. is proposed. The type strain is TH92(T) (=CGMCC 1.6992(T) =JCM 15153(T)).

Getting out of bed after surgery

MedlinePlus

... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 13. Smith SF, Duell DJ, Martin ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 26. Patient Instructions Gallbladder removal - open - ...

75 FR 25925 - United States Mint

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-10

..., United States Mint, 801 9th Street, NW., Washington, DC 20220. Subject: Review and discuss obverse and..., United States Mint Liaison to the CCAC; 801 9th Street, NW., Washington, DC 20220; or call 202-354-7200...

METHODOLOGICAL ISSUES IN THE USE OF GENERALIZED ADDITIVE MODELS FOR THE ANALYSIS OF PARTICULATE MATTER; CONFERENCE PROCEEDINGS FOR 9TH INT'L. INHALATION SYMPOSIUM ON EFFECTS OF AIR CONTAMINANTS ON THE RESPIRATORY TRACT - INTERPRETATIONS FROM MOLECULES TO META ANALYSIS

EPA Science Inventory

Open cohort ("time-series") studies of the adverse health effects of short-term exposures to ambient particulate matter and gaseous co-pollutants have been essential in the standard setting process. Last year, a number of serious issues were raised concerning the fitting of Gener...

Performance Analysis of the Probabilistic Multi-Hypothesis Tracking Algorithm on the SEABAR Data Sets

DTIC Science & Technology

2009-07-01

Performance Analysis of the Probabilistic Multi- Hypothesis Tracking Algorithm On the SEABAR Data Sets Dr. Christian G . Hempel Naval...Hypothesis Tracking,” NUWC-NPT Technical Report 10,428, Naval Undersea Warfare Center Division, Newport, RI, 15 February 1995. [2] G . McLachlan, T...the 9th International Conference on Information Fusion, Florence Italy, July, 2006. [8] C. Hempel, “Track Initialization for Multi-Static Active Sonay

Early 20th Century Education in the United States: The Role of the Brothers of Holy Cross

ERIC Educational Resources Information Center

Armstrong, Philip C.

2007-01-01

The French Revolution bears an ironic responsibility for generating works of charity. To counteract the devastating social effects of that late 18th century uprising, numerous religious communities were founded in France, among them the Congregation of Holy Cross. The Congregation of Holy Cross, the founding religious community behind the…

Noise level in a neonatal intensive care unit in Santa Marta - Colombia.

PubMed Central

Garrido Galindo, Angélica Patricia; Velez-Pereira, Andres M

2017-01-01

Abstract Introduction: The environment of neonatal intensive care units is influenced by numerous sources of noise emission, which contribute to raise the noise levels, and may cause hearing impairment and other physiological and psychological changes on the newborn, as well as problems with care staff. Objective: To evaluate the level and sources of noise in the neonatal intensive care unit. Methods: Sampled for 20 consecutive days every 60 seconds in A-weighting curves and fast mode with a Type I sound level meter. Recorded the average, maximum and minimum, and the 10th, 50th and 90th percentiles. The values are integrated into hours and work shift, and studied by analysis of variance. The sources were characterized in thirds of octaves. Results: The average level was 64.00 ±3.62 dB(A), with maximum of 76.04 ±5.73 dB(A), minimum of 54.84 ±2.61dB(A), and background noise of 57.95 ±2.83 dB(A). We found four sources with levels between 16.8-63.3 dB(A). Statistical analysis showed significant differences between the hours and work shift, with higher values in the early hours of the day. Conclusion: The values presented exceed the standards suggested by several organizations. The sources identified and measured recorded high values in low frequencies. PMID:29213154

Developmental and individual differences in pure numerical estimation.

PubMed

Booth, Julie L; Siegler, Robert S

2006-01-01

The authors examined developmental and individual differences in pure numerical estimation, the type of estimation that depends solely on knowledge of numbers. Children between kindergarten and 4th grade were asked to solve 4 types of numerical estimation problems: computational, numerosity, measurement, and number line. In Experiment 1, kindergartners and 1st, 2nd, and 3rd graders were presented problems involving the numbers 0-100; in Experiment 2, 2nd and 4th graders were presented problems involving the numbers 0-1,000. Parallel developmental trends, involving increasing reliance on linear representations of numbers and decreasing reliance on logarithmic ones, emerged across different types of estimation. Consistent individual differences across tasks were also apparent, and all types of estimation skill were positively related to math achievement test scores. Implications for understanding of mathematics learning in general are discussed. Copyright 2006 APA, all rights reserved.

Judicial Review under NEPA -- Lessons for Users of Various Approaches to Environmental Impact Assessment.

DTIC Science & Technology

1980-01-01

form in which it was reiterated by the 9th Circuit during review of the Teton Dam : "A reasonably thorough discussion of the significant aspects of the...require- ments have not been honored. ’ 2/ In its review of the impact statement for the Teton Dam , the 9th Circuit comnented on allegations that the...be done in a meaningful way. For example, in reviewing the impact statement for the Teton Dam , the 9th Circuit responded as follows to the plaintiffs

Comparison of synchrotron radiation and conventional x-ray microcomputed tomography for assessing trabecular bone microarchitecture of human femoral heads

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chappard, Christine; Basillais, Armelle; Benhamou, Laurent

Microcomputed tomography ({mu}CT) produces three-dimensional (3D) images of trabecular bone. We compared conventional {mu}CT (C{mu}CT) with a polychromatic x-ray cone beam to synchrotron radiation (SR) {mu}CT with a monochromatic parallel beam for assessing trabecular bone microarchitecture of 14 subchondral femoral head specimens from patients with osteoarthritis (n=10) or osteoporosis (n=4). SR{mu}CT images with a voxel size of 10.13 {mu}m were reconstructed from 900 2D radiographic projections (angular step, 0.2 deg. ). C{mu}CT images with a voxel size of 10.77 {mu}m were reconstructed from 205, 413, and 825 projections obtained using angular steps of 0.9 deg., 0.45 deg., and 0.23 deg.,more » respectively. A single threshold was used to binarize the images. We computed bone volume/tissue volume (BV/TV), bone surface/bone volume (BS/BV), trabecular number (Tb.N), trabecular thickness (Tb.Th and Tb.Th*), trabecular spacing (Tb.Sp), degree of anisotropy (DA), and Euler density. With the 0.9 deg. angular step, all C{mu}CT values were significantly different from SR{mu}CT values. With the 0.23 deg. and 0.45 deg. rotation steps, BV/TV, Tb.Th, and BS/BV by C{mu}CT differed significantly from the values by SR{mu}CT. The error due to slice matching (visual site matching {+-}10 slices) was within 1% for most parameters. Compared to SR{mu}CT, BV/TV, Tb.Sp, and Tb.Th by C{mu}CT were underestimated, whereas Tb.N and Tb.Th* were overestimated. A Bland and Altman plot showed no bias for Tb.N or DA. Bias was -0.8{+-}1.0%, +5.0{+-}1.1 {mu}m, -5.9{+-}6.3 {mu}m, and -5.7{+-}29.1 {mu}m for BV/TV, Tb.Th*, Tb.Th, and Tb.Sp, respectively, and the differences did not vary over the range of values. Although systematic differences were noted between SR{mu}CT and C{mu}CT values, correlations between the techniques were high and the differences would probably not change the discrimination between study groups. C{mu}CT provides a reliable 3D assessment of human defatted bone when working at the 0.23 deg. or 0.45 deg. rotation step; the 0.9 deg. rotation step may be insufficiently accurate for morphological bone analysis.« less

Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment.

PubMed

Shaffer, John R; Li, Jinxi; Lee, Myoung Keun; Roosenboom, Jasmien; Orlova, Ekaterina; Adhikari, Kaustabh; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; González-José, Rolando; Pfeffer, Paige E; Wollenschlaeger, Christopher A; Hecht, Jacqueline T; Wehby, George L; Moreno, Lina M; Ding, Anan; Jin, Li; Yang, Yajun; Carlson, Jenna C; Leslie, Elizabeth J; Feingold, Eleanor; Marazita, Mary L; Hinds, David A; Cox, Timothy C; Wang, Sijia; Ruiz-Linares, Andrés; Weinberg, Seth M

2017-12-07

The genetic basis of earlobe attachment has been a matter of debate since the early 20 th century, such that geneticists argue both for and against polygenic inheritance. Recent genetic studies have identified a few loci associated with the trait, but large-scale analyses are still lacking. Here, we performed a genome-wide association study of lobe attachment in a multiethnic sample of 74,660 individuals from four cohorts (three with the trait scored by an expert rater and one with the trait self-reported). Meta-analysis of the three expert-rater-scored cohorts revealed six associated loci harboring numerous candidate genes, including EDAR, SP5, MRPS22, ADGRG6 (GPR126), KIAA1217, and PAX9. The large self-reported 23andMe cohort recapitulated each of these six loci. Moreover, meta-analysis across all four cohorts revealed a total of 49 significant (p < 5 × 10 -8 ) loci. Annotation and enrichment analyses of these 49 loci showed strong evidence of genes involved in ear development and syndromes with auricular phenotypes. RNA sequencing data from both human fetal ear and mouse second branchial arch tissue confirmed that genes located among associated loci showed evidence of expression. These results provide strong evidence for the polygenic nature of earlobe attachment and offer insights into the biological basis of normal and abnormal ear development. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Assessing Online Patient Education Readability for Spine Surgery Procedures.

PubMed

Long, William W; Modi, Krishna D; Haws, Brittany E; Khechen, Benjamin; Massel, Dustin H; Mayo, Benjamin C; Singh, Kern

2018-03-01

Increased patient reliance on Internet-based health information has amplified the need for comprehensible online patient education articles. As suggested by the American Medical Association and National Institute of Health, spine fusion articles should be written for a 4th-6th-grade reading level to increase patient comprehension, which may improve postoperative outcomes. The purpose of this study is to determine the readability of online health care education information relating to anterior cervical discectomy and fusion (ACDF) and lumbar fusion procedures. Online health-education resource qualitative analysis. Three search engines were utilized to access patient education articles for common cervical and lumbar spine procedures. Relevant articles were analyzed for readability using Readability Studio Professional Edition software (Oleander Software Ltd). Articles were stratified by organization type as follows: General Medical Websites (GMW), Healthcare Network/Academic Institutions (HNAI), and Private Practices (PP). Thirteen common readability tests were performed with the mean readability of each compared between subgroups using analysis of variance. ACDF and lumbar fusion articles were determined to have a mean readability of 10.7±1.5 and 11.3±1.6, respectively. GMW, HNAI, and PP subgroups had a mean readability of 10.9±2.9, 10.7±2.8, and 10.7±2.5 for ACDF and 10.9±3.0, 10.8±2.9, and 11.6±2.7 for lumbar fusion articles. Of 310 total articles, only 6 (3 ACDF and 3 lumbar fusion) were written for comprehension below a 7th-grade reading level. Current online literature from medical websites containing information regarding ACDF and lumbar fusion procedures are written at a grade level higher than the suggested guidelines. Therefore, current patient education articles should be revised to accommodate the average reading level in the United States and may result in improved patient comprehension and postoperative outcomes.

A Freshman Academy's Influence on Student Connectivity, Attendance, and Academic Achievement

ERIC Educational Resources Information Center

LoPresti, Nancy O.

2017-01-01

The transition from 8th to 9th grade, from middle school to high school, is considered one of the most challenging experiences in an adolescent's life. Ninth-grade transition programs, often referred to as freshman academies, have been developed and implemented over the last decade to address the needs of 9th grade students. The purpose of this…

Social and Academic Expectations about High School for At-Risk Rural Youth

ERIC Educational Resources Information Center

Stein, Gabriela Livas; Hussong, Andrea

2007-01-01

This study examines high school expectancies in a sample of at-risk, rural youth, and how these expectancies relate to 8th grade functioning, 9th grade functioning, and 9th grade experiences of high school. A total of 76 eighth-graders and their parents, drawn from a larger study of the transition to high school, participated in interviews the…

[Morbidity rate and mental capacity of Moscow schoolchildren (longitudinal study)].

PubMed

Sukhareva, L M; Rapoport, I K; Polenova, M A

2014-01-01

In the article there are presented data of longitudinal study of the health of Moscow schoolchildren (426 children), followed throughout from the 1st to 9th class, inclusively. Students were annually clinically examined in the school. There was performed a comprehensive study of mental health and functional state of the organism in the process of education students in high school (over 2700 pupils of 5-9th classes). The health status of students was shown to deteriorate due to the increase of the prevalence of chronic disease, the rise in occupancy of the III-IV health groups, the decrease of the number of children referred to I and II health groups. Unfavorable trends in the health state among boys are more pronounced than in girls, while they are also characterized by lower functional capabilities of the CNS and lower resistance to the development of training fatigue. Relatively favorable stage of school ontogeny is characterized by period with reduced morbidity in children studying in 4th-6th classes. Deterioration in the health of students as a significant rate of the rise of chronic diseases morbidity is observed in 7-9th classes. Along with this, in the 7th and 9th classes there is revealed the deterioration of mental capacity and high frequency of the pronounced signs of fatigue among schoolchildren.

Fitness adjusted racial disparities in central adiposity among women in the USA using quantile regression.

PubMed

McDonald, S; Ortaglia, A; Supino, C; Kacka, M; Clenin, M; Bottai, M

2017-06-01

This study comprehensively explores racial/ethnic disparities in waist circumference (WC) after adjusting for cardiorespiratory fitness (CRF), among both adult and adolescent women, across WC percentiles. Analysis was conducted using data from the 1999 to 2004 National Health and Nutrition Examination Survey. Female participants ( n  = 3,977) aged 12-49 years with complete data on CRF, height, weight and WC were included. Quantile regression models, stratified by age groups (12-15, 16-19 and 20-49 years), were used to assess the association between WC and race/ethnicity adjusting for CRF, height and age across WC percentiles (10th, 25th, 50th, 75th, 90th and 95th). For non-Hispanic (NH) Black, in both the 16-19 and 20-49 years age groups, estimated WC was significantly greater than for NH White across percentiles above the median with estimates ranging from 5.2 to 11.5 cm. For Mexican Americans, in all age groups, estimated WC tended to be significantly greater than for NH White particularly for middle percentiles (50th and 75th) with point estimates ranging from 1.9 to 8.4 cm. Significant disparities in WC between NH Black and Mexican women, as compared to NH White, remain even after adjustment for CRF. The magnitude of the disparities associated with race/ethnicity differs across WC percentiles and age groups.

Method for predicting water demand for crop uses in New Jersey in 1990, 2000, 2010, and 2020, and for estimating water use for livestock and selected sectors of the food-processing industry in New Jersey in 1987

USGS Publications Warehouse

Clawges, R.M.; Titus, E.O.

1993-01-01

A method was developed to predict water demand for crop uses in New Jersey. A separate method was developed to estimate water use for livestock and selected sectors of the food-processing industry in 1987. Predictions of water demand for field- grown crops in New Jersey were made for 1990, 2000, 2010, and 2020 under three climatological scenarios: (1) wet year, (2) average year, and (3) drought year. These estimates ranged from 4.10 times 10 to the 9th power to 16.82 times 10 to the 9th power gal (gallons). Irrigation amounts calculated for the three climatological scenarios by using a daily water-balance model were multiplied by predicted numbers of irrigated acreage. Irrigated acreage was predicted from historical crop-irrigation data and from predictions of harvested acreage produced by using a statistical model relating population to harvested acreage. Predictions of water demand for cranberries and container-grown nursery crops also were made for 1990, 2000, 2010, and 2020. Predictions of water demand under the three climatological scenarios were made for container- grown nursery crops, but not for cranberries, because water demand for cranberries varies little in response to climatological factors. Water demand for cranberries was predicted to remain constant at 4.43 times 10 to the 9th power gal through the year 2020. Predictions of water demand for container-grown nursery crops ranged from 1.89 times 10 to the 9th power to 3.63 times 10 to the 9th power gal. Water-use for livestock in 1987 was estimated to be 0.78 times 10 to the 9th power gal, and water use for selected sectors of the food-processing industry was estimated to be 3.75 times 10 to the 9th power gal.

Elevated concentrations of naturally occurring radionuclides in heavy mineral-rich beach sands of Langkawi Island, Malaysia.

PubMed

Khandaker, Mayeen Uddin; Asaduzzaman, Khandoker; Sulaiman, Abdullah Fadil Bin; Bradley, D A; Isinkaye, Matthew Omoniyi

2018-02-01

Study is made of the radioactivity in the beach sands of Langkawi island, a well-known tourist destination. Investigation is made of the relative presence of the naturally occurring radionuclide 40 K and the natural-series indicator radionuclides 226 Ra and 232 Th, the gamma radiation exposure also being estimated. Sample quantities of black and white sand were collected for gamma ray spectrometry, yielding activity concentration in black sands of 226 Ra, 232 Th and 40 K from 451±9 to 2411±65Bqkg -1 (mean of 1478Bqkg -1 ); 232±4 to 1272±35Bqkg -1 (mean of 718Bqkg -1 ) and 61±6 to 136±7Bqkg -1 (mean of 103Bqkg -1 ) respectively. Conversely, in white sands the respective values for 226 Ra and 232 Th were appreciably lower, at 8.3±0.5 to 13.7±1.4Bqkg -1 (mean of 9.8Bqkg -1 ) and 4.5±0.7 to 9.4±1.0Bqkg -1 (mean of 5.9Bqkg -1 ); 40 K activities differed insubstantially from that in black sands, at 85±4 to 133±7Bqkg -1 with a mean of 102Bqkg -1 . The mean activity concentrations of 226 Ra and 232 Th in black sands are comparable with that of high background areas elsewhere in the world. The heavy minerals content gives rise to elevated 226 Ra and 232 Th activity concentrations in all of black sand samples. Evaluation of the various radiological risk parameters points to values which in some cases could be in excess of recommendations providing for safe living and working. Statistical analysis examines correlations between the origins of the radionuclides, also identifying and classifying the radiological parameters. Present results may help to form an interest in rare-earth resources for the electronics industry, power generation and the viability of nuclear fuels cycle resources. Copyright © 2017 Elsevier Ltd. All rights reserved.

Integrating spatial and numerical structure in mathematical patterning

NASA Astrophysics Data System (ADS)

Ni’mah, K.; Purwanto; Irawan, E. B.; Hidayanto, E.

2018-03-01

This paper reports a study monitoring the integrating spatial and numerical structure in mathematical patterning skills of 30 students grade 7th of junior high school. The purpose of this research is to clarify the processes by which learners construct new knowledge in mathematical patterning. Findings indicate that: (1) students are unable to organize the structure of spatial and numerical, (2) students were only able to organize the spatial structure, but the numerical structure is still incorrect, (3) students were only able to organize numerical structure, but its spatial structure is still incorrect, (4) students were able to organize both of the spatial and numerical structure.

9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

Correlation of genetic risk and messenger RNA expression in a Th17/IL23 pathway analysis in inflammatory bowel disease.

PubMed

Fransen, Karin; van Sommeren, Suzanne; Westra, Harm-Jan; Veenstra, Monique; Lamberts, Letitia E; Modderman, Rutger; Dijkstra, Gerard; Fu, Jingyuan; Wijmenga, Cisca; Franke, Lude; Weersma, Rinse K; van Diemen, Cleo C

2014-05-01

The Th17/IL23 pathway has both genetically and biologically been implicated in the pathogenesis of the inflammatory bowel diseases (IBD), Crohn's disease, and ulcerative colitis. So far, it is unknown whether and how associated risk variants affect expression of the genes encoding for Th17/IL23 pathway proteins. Ten IBD-associated SNPs residing near Th17/IL23 genes were used to construct a genetic risk model in 753 Dutch IBD cases and 1045 controls. In an independent cohort of 40 Crohn's disease, 40 ulcerative colitis, and 40 controls, the genetic risk load and presence of IBD were correlated to quantitative PCR-generated messenger RNA (mRNA) expression of 9 representative Th17/IL23 genes in both unstimulated and PMA/CaLo stimulated peripheral blood mononuclear cells. In 1240 individuals with various immunological diseases with whole genome genotype and mRNA-expression data, we also assessed correlation between genetic risk load and differential mRNA expression and sought for SNPs affecting expression of all currently known Th17/IL23 pathway genes (cis-expression quantitative trait locus). The presence of IBD, but not the genetic risk load, was correlated to differential mRNA expression for IL6 in unstimulated peripheral blood mononuclear cells and to IL23A and RORC in response to stimulation. The cis-expression quantitative trait locus analysis showed little evidence for correlation between genetic risk load and mRNA expression of Th17/IL23 genes, because we identified for only 2 of 22 Th17/IL23 genes a cis-expression quantitative trait locus single nucleotide polymorphism that is also associated to IBD (STAT3 and CCR6). Our results suggest that only the presence of IBD and not the genetic risk load alters mRNA expression levels of IBD-associated Th17/IL23 genes.

The Coast Artillery Journal. Volume 59, Number 3, September 1923

DTIC Science & Technology

1923-09-01

action of van Billow and van Hausen in pressing back the front too soon, thus causing a withdrawal before van Kluck could reach the flank. With any...his forces were south of the Marne, but he succeeded in falling back to the Ourcq. On the 7th von Kluck still hard pressed , recalled his 3rd and 9th...conform to the line. This per- mitted the 5th French Army to send aid to Foch’s 9th Army in the centre, which had been especially hard pressed by von Billow

Behavioral and community correlates of adolescent pregnancy and Chlamydia rates in rural counties in Minnesota.

PubMed

Kozhimannil, Katy B; Enns, Eva; Blauer-Peterson, Cori; Farris, Jill; Kahn, Judith; Kulasingam, Shalini

2015-06-01

Identifying co-occurring community risk factors, specific to rural communities, may suggest new strategies and partnerships for addressing sexual health issues among rural youth. We conducted an ecological analysis to identify the county-level correlates of pregnancy and chlamydia rates among adolescents in rural (nonmetropolitan) counties in Minnesota. Pregnancy and chlamydia infection rates among 15-19 year-old females were compared across Minnesota's 87 counties, stratified by rural/urban designations. Regression models for rural counties (n = 66) in Minnesota were developed based on publicly available, county-level information on behaviors and risk exposures to identify associations with teen pregnancy and chlamydia rates in rural settings. Adolescent pregnancy rates were higher in rural counties than in urban counties. Among rural counties, factors independently associated with elevated county-level rates of teen pregnancy included inconsistent contraceptive use by 12th-grade males, fewer 12th graders reporting feeling safe in their neighborhoods, more 9th graders reporting feeling overweight, fewer 12th graders reporting 30 min of physical activity daily, high county rates of single parenthood, and higher age-adjusted mortality (P < .05 for all associations). Factors associated with higher county level rates of chlamydia among rural counties were inconsistent condom use reported by 12th-grade males, more 12th graders reporting feeling overweight, and more 12th graders skipping school in the past month because they felt unsafe. This ecologic analysis suggests that programmatic approaches focusing on behavior change among male adolescents, self-esteem, and community health and safety may be complementary to interventions addressing teen sexual health in rural areas; such approaches warrant further study.

Behavioral and Community Correlates of Adolescent Pregnancy and Chlamydia Rates in Rural Counties in Minnesota1

PubMed Central

Kozhimannil, Katy B.; Enns, Eva; Blauer-Peterson, Cori; Farris, Jill; Kahn, Judith; Kulasingam, Shalini

2014-01-01

Purpose Identifying co-occurring community risk factors, specific to rural communities, may suggest new strategies and partnerships for addressing sexual health issues among rural youth. We conducted an ecological analysis to identify the county-level correlates of pregnancy and chlamydia rates among adolescents in rural (nonmetropolitan) counties in Minnesota. Methods Pregnancy and chlamydia infection rates among 15–19 year-old females were compared across Minnesota’s 87 counties, stratified by rural/urban designations. Regression models for rural counties (n=66) in Minnesota were developed based on publicly available, county-level information on behaviors and risk exposures to identify associations with teen pregnancy and chlamydia rates in rural settings. Findings Adolescent pregnancy rates were higher in rural counties than in urban counties. Among rural counties, factors independently associated with elevated county-level rates of teen pregnancy included inconsistent contraceptive use by 12th-grade males, fewer 12th graders reporting feeling safe in their neighborhoods, more 9th graders reporting feeling overweight, fewer 12th graders reporting 30 min of physical activity daily, high county rates of single parenthood, and higher age-adjusted mortality (P < .05 for all associations). Factors associated with higher county level rates of chlamydia among rural counties were inconsistent condom use reported by 12th-grade males, more 12th graders reporting feeling overweight, and more 12th graders skipping school in the past month because they felt unsafe. Conclusions This ecologic analysis suggests that programmatic approaches focusing on behavior change among male adolescents, self-esteem, and community health and safety may be complementary to interventions addressing teen sexual health in rural areas; such approaches warrant further study. PMID:25344773

Unresectable Hepatocellular Carcinoma: MR Imaging after Intraarterial Therapy. Part I. Identification and Validation of Volumetric Functional Response Criteria

PubMed Central

Bonekamp, Susanne; Li, Zhen; Geschwind, Jean-François H.; Halappa, Vivek Gowdra; Corona-Villalobos, Celia Pamela; Reyes, Diane; Pawlik, Timothy M.; Bonekamp, David; Eng, John

2013-01-01

Purpose: To identify and validate the optimal thresholds for volumetric functional MR imaging response criteria to predict overall survival after intraarterial treatment (IAT) in patients with unresectable hepatocellular carcinoma (HCC). Materials and Methods: Institutional review board approval and waiver of informed consent were obtained. A total of 143 patients who had undergone MR imaging before and 3–4 weeks after the first cycle of IAT were included. MR imaging analysis of one representative HCC index lesion was performed with proprietary software after initial treatment. Subjects were randomly divided into training (n = 114 [79.7%]) and validation (n = 29 [20.3%]) data sets. Uni- and multivariate Cox models were used to determine the best cutoffs, as well as survival differences, between response groups in the validation data set. Results: Optimal cutoffs in the training data set were 23% increase in apparent diffusion coefficient (ADC) and 65% decrease in volumetric enhancement in the portal venous phase (VE). Subsequently, 25% increase in ADC and 65% decrease in VE were used to stratify patients in the validation data set. Comparison of ADC responders (n = 12 [58.6%]) with nonresponders (n = 17 [34.5%]) showed significant differences in survival (25th percentile survival, 11.2 vs 4.9 months, respectively; P = .008), as did VE responders (n = 9 [31.0%]) compared with nonresponders (n = 20 [69.0%]; 25th percentile survival, 11.5 vs 5.1 months, respectively; P = .01). Stratification of patients with a combination of the criteria resulted in significant differences in survival between patients with lesions that fulfilled both criteria (n = 6 [20.7%]; too few cases to determine 25th percentile), one criterion (n = 9 [31.0%]; 25th percentile survival, 6.0 months), and neither criterion (n = 14 [48.3%]; 25th percentile survival, 5.1 months; P = .01). The association between the two criteria and overall survival remained significant in a multivariate analysis that included age, sex, Barcelona Clinic for Liver Cancer stage, and number of follow-up treatments. Conclusion: After IAT for unresectable HCC, patients can be stratified into significantly different survival categories based on responder versus nonresponder status according to MR imaging ADC and VE cutoffs. © RSNA, 2013 PMID:23616631

Calculations of the moon's thermal history at different concentrations of radioactive elements, taking into account differentiation on melting

NASA Technical Reports Server (NTRS)

Ornatskaya, O. I.; Alber, Y. I.; Ryazantseva, I. L.

1977-01-01

Calculations of the thermal history of the moon were done by solving the thermal conductivity equation for the case in which the heat sources are the long lived radioactive elements Th, U, and K-40. The concentrations of these elements were adjusted to give 4 variations of heat flow. Calculations indicated that the moon's interior was heated to melting during the first 0.7 to 2.3 x 10 to the 9th power years. The maximum fusion involved practically the entire moon to a distance from 15 to 45 km beneath the surface, and started 3.5 to 4.0 x 10 to the 9th power years ago, or 2.5 x 3.0 x 10 to the 9th power years ago and continued for 1 to 2 x 10 to the 9th power years. The moon today is cooling. The current thickness of the solid crust is from 150 to 200 km and the heat flow exceeds the stationary value 1.5 fold.

[Evaluation study on integration effect of taohong siwu tang in treating primary dysmenorrhea].

PubMed

Liu, Li; Duan, Jin-Ao; Hua, Yong-Qing; Liu, Pei; Shang, Er-Xin; Tang, Yu-Ping; Su, Shu-Lan

2012-11-01

To evaluate the effect of Taohong Siwu Tang and its fractions on hotplate-induced pain in mice, acetic acid-induced writhing response, dysmenorrheal model and isolated uterine contraction in vitro in mice, and discuss material basis of effect sites. The samples of fractions were prepared by macroporous adsorptive resins (TH-1-TH-15). In the whole animal experiment, the hotplate-induced pain mice model was established to observe the effect of the samples on pain threshold in mice; the acetic acid-induced writhing response mice model was built to observe the effect of the samples on the writhing response in mice; the mice dysmenorrheal model was established to observe the effect of the samples on the writhing response, and calcium ion (Ca2+) and nitric oxide (NO) levels in uterine tissue of mice. In the isolated uterus contraction experiment, the oxytocin-induced isolated uterus contraction mice model was established to observe the effect of the samples on the isolated uterus contraction index. HPLC-DAD method was adopted for the content determination of effect sites. According to the evaluation of the integration geological effect, beside TH-2 and TH-4, other three active fractions (TH-9, TH-10 and TH-11) extracted from Taohong Siwu Tang are the main effect sites. Their chemical components were analyzed and identified as monoterpene glycosides, phthalides, organic acids, etc. The effect sites of Taohong Siwu Tang on dysmenorrhea are TH-9, TH-10 and TH-11, which are 30% - 50% active fractions obtained from water-soluble small-molecular fractions by gradient elution using ethanol through macroporous absorption resin. Compared with TH-10 and TH-11, TH-9 shows stronger effect, which may be related to the type and content of chemical components it contains.

[Alternation of proteins in brain of Parkinson's disease model rats after the transplantation of TH-NTN gene modified bone marrow mesenchymal stem cells].

PubMed

Huang, Yue; Chang, Cheng; Zhang, Jie-wen; Gao, Xiao-qun

2012-09-04

To explore the effects of tyrosine hydroxylase-neurturin (TH-NTN) gene modified bone marrow mesenchymal stem cell (BMSC) transplantation in Parkinson's disease (PD) model rats and the alternations of correlated proteins. The PD rat model was established by the 2-point injection of 6-hydroxydopamine (6-OHDA) into unilateral (right) striatum. Successful modeling rats were separated into PD, BMSC and TH-NTN-BMSC groups. BMSC and TH-NTN-BMSC groups were transplanted into BMSCs and TH-NTN gene modified BMSC cells separately into right striatum. After transplantation, ethology detection in all groups was made with an intraperitoneal injection of apomorphine (APO). Dopamine (DA) and Dihydroxyphenylacetic Acid (DOPAC) in striatum were detected by high performance liquid electrochemical analysis. TH and NTN proteins in right striatum were also analyzed by immunohistochemistry and Western blot. Finally the density of dopamine receptors in post synaptic density of dopaminergic synapses of corpus striatum were compared between each group by post-embedding immunogold electron microscopy. After an injection of APO, rotation frequency decreased in TH-NTN-BMSC group, i.e. (5.7 ± 1.3) circles/min versus (10.8 ± 2.2), (9.9 ± 1.2) circles/min in PD and BMSC groups (P < 0.05). For proteins in right striatum, DA, (0.421 ± 0.113) and DOPAC, (0.093 ± 0.012) nmol/L increased significantly versus (0.208 ± 0.043), (0.043 ± 0.017) nmol/L in PD and (0.231 ± 0.082), (0.044 ± 0.023)noml/L in BMSC groups (P < 0.05). Also a lower density of D2 receptors at (623 ± 96)/µm(2) in TH-NTN-BMSC group versus (923 ± 132)/µm(2) in PD and (860 ± 116)/µm(2) in BMSC groups was also found. The combined therapy of TH and NTN genes increases the synthesis of DA and also protects the dopaminergic neurons to achieve double therapeutic effects. It may provide potential innovations of PD genetic therapy.

Changes in intensity of precipitation extremes in Romania on very hight temporal scale and implications on the validity of the Clausius-Clapeyron relation

NASA Astrophysics Data System (ADS)

Busuioc, Aristita; Baciu, Madalina; Breza, Traian; Dumitrescu, Alexandru; Stoica, Cerasela; Baghina, Nina

2016-04-01

Many observational, theoretical and based on climate model simulation studies suggested that warmer climates lead to more intense precipitation events, even when the total annual precipitation is slightly reduced. In this way, it was suggested that extreme precipitation events may increase at Clausius-Clapeyron (CC) rate under global warming and constraint of constant relative humidity. However, recent studies show that the relationship between extreme rainfall intensity and atmospheric temperature is much more complex than would be suggested by the CC relationship and is mainly dependent on precipitation temporal resolution, region, storm type and whether the analysis is conducted on storm events rather than fixed data. The present study presents the dependence between the very hight temporal scale extreme rainfall intensity and daily temperatures, with respect to the verification of the CC relation. To solve this objective, the analysis is conducted on rainfall event rather than fixed interval using the rainfall data based on graphic records including intensities (mm/min.) calculated over each interval with permanent intensity per minute. The annual interval with available a such data (April to October) is considered at 5 stations over the interval 1950-2007. For Bucuresti-Filaret station the analysis is extended over the longer interval (1898-2007). For each rainfall event, the maximum intensity (mm/min.) is retained and these time series are considered for the further analysis (abbreviated in the following as IMAX). The IMAX data were divided based on the daily mean temperature into bins 2oC - wide. The bins with less than 100 values were excluded. The 90th, 99th and 99.9th percentiles were computed from the binned data using the empirical distribution and their variability has been compared to the CC scaling (e.g. exponential relation given by a 7% increase per temperature degree rise). The results show a dependence close to double the CC relation for temperatures less than ~ 220C and negative scaling rates for higher temperatures. This behaviour is similar for all the 5 analysed stations over the common interval 1950-2007. This scaling is more exactly for the 90th percentile, while for the higher percentiles the rainfall intensity in response to warming exceeds sometimes the CC rate. For Bucuresti-Filaret station, the results are similar over a longer interval (1898-2007) showing that these findings are robust. Similar techniques has been previously applied to the hourly rainfall intensities recorded at 9 stations (including the 5 ones) and the results are slightly different: the 90th percentile shows dependence close to the CC relation for all temperatures; the 99th and 99.9th percentiles exhibit rates close to double the CC rate for temperatures between ~ 100C and ~ 220C and negative scaling rates for higher temperatures. In conclusion, these results show that the dependence between the extreme precipitation intensity and atmospheric temperature in Romania is mainly dependent on the temporal precipitation resolution and the degree of the extreme precipitation event (moderate or stronger); these findings are mainly in agreenment with the conclusions presented by previous international studies (mentioned above), with some regional specific features, showing the importance of the regional studies. The results presented is this study were funded by the Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI) through the research project CLIMHYDEX, "Changes in climate extremes and associated impact in hydrological events in Romania", code PNII-ID-2011-2-0073 (http://climhydex.meteoromania.ro).

Evaluation methods and evaporation conditions for low-resistivity contacts on high Tc superconductors

NASA Astrophysics Data System (ADS)

Liu, Y. P.; Warner, K.; Chan, C.; Chen, K.; Markiewicz, R.

1989-12-01

Low-resistivity contacts to bulk high-Tc superconductors have been prepared by resistive evaporation with values of rho-s (ohm sq cm) as low as 10 to the -10th (77 K) for Ag/YBaCuO, 10 to the -9th (77 K) for Ag/TlPbBaCaCuO, and 10 to the 7th (60 K) for Ag/BiCaSrCuO. It was found that rho-s is improved by increasing the length of a preevaporation step. This effect has been further investigated by secondary ion-mass spectrometry analysis on several Ag/Si samples. Both three-terminal and four-terminal methods have been used to determine rho-s; the three-terminal method shows less dependency on the sample/contact geometry for measurements taken above Tc.

An open-framework thorium sulfate hydrate with 11.5 A voids.

PubMed

Wilson, Richard E; Skanthakumar, S; Knope, Karah E; Cahill, Christopher L; Soderholm, L

2008-10-20

We report the synthesis of a thorium sulfate hydrate with 11.5 A open channels that propagate through the structure. The compound crystallizes in the tetragonal space group P4(2)/nmc, a = b = 25.890(4) A, c = 9.080(2) A, Z = 8, V = 6086.3(2) A(3). The thermal stability of the compound was investigated using thermogravimetric analysis and high-energy X-ray scattering (HEXS) revealing that the compound begins to undergo decomposition near 200 degrees C with an accompanied loss in crystallinity. The immediate coordination environment about the thorium atoms remains intact through heating to 500 degrees C as demonstrated by HEXS. Further heating reveals the formation of at least two crystalline phases, Th(SO4)2 and ThO2, which ultimately decompose to ThO2.

Levels in the U.S. population of those persistent organic pollutants (2003-2004) included in the Stockholm Convention or in other long range transboundary air pollution agreements.

PubMed

Patterson, Donald G; Wong, Lee-Yang; Turner, Wayman E; Caudill, Samuel P; Dipietro, Emily S; McClure, Patricia C; Cash, Troy P; Osterloh, John D; Pirkle, James L; Sampson, Eric J; Needham, Larry L

2009-02-15

We report human serum levels of selected persistent organic pollutants (POPs) categorized by age, sex, and race/ ethnicity from a statistically representative sampling of the U.S. population during 2003 and 2004. The serum levels are for several chemicals listed in the Stockholm Convention on Persistent Organic Pollutants, in the Geneva Convention on Long-Range Transboundary Air Pollution, or in both. Population data for each chemical are described by geometric means and percentiles and are categorized by age, sex, and race/ ethnicity. At the 90th and 95th percentile, the dioxin total toxic equivalency (TEQ), using the 2005 toxic equivalency factors (TEFs) for all persons 12 years of age and older was 30.9 pg/g lipid (95% confidence interval (CI): 28.2-33.9 pg/g lipid) and 37.8 pg/g lipid (95% CI: 35.3-43.4 pg/g lipid), respectively. At both the 90th and 95th percentiles total TEQ increased significantly with increasing age. The population geometric mean (GM) for the total PCB concentration (sum of 35 congeners) for all persons 12 years of age and older was 0.820 ng/g whole-weight (95% CI: 0.782-0.863 ng/g whole-weight) and 134.4 ng/g lipid (95% CI: 128.9-140.0 ng/g lipid). The population 95th percentile for the total PCB concentration for all persons 12 years of age and older was 3.53 ng/g whole-weight (95% CI: 3.23-3.92 ng/g whole-weight) and 531 ng/g lipid (95% CI: 498-570 ng/g lipid). The concentrations of aldrin, endrin, gamma-HCH, and o,p'-DDT were

Cometary delivery of organic molecules to the early earth

NASA Technical Reports Server (NTRS)

Chyba, Christopher F.; Thomas, Paul J.; Sagan, Carl; Brookshaw, Leigh

1990-01-01

It has long been speculated that earth accreted prebiotic organic molecules important for the origins of life from impacts of carbonaceous asteroids and comets during the period of heavy bombardment 4.5 x 10 to the 9th to 3.8 x 10 to the 9th years ago. A comprehensive treatment of comet-asteroid interaction with the atmosphere, surface impact, and resulting organic pyrolysis demonstrates that organics will not survive impacts at velocities greater than about 10 kilometers per second and that even comets and asteroids as small as 100 meters in radius cannot be aerobraked to below this velocity in 1-bar atmospheres. However, for plausible dense (10-bar carbon dioxide) early atmospheres, it is found that 4.5 x 10 to the 9th years ago earth was accreting intact cometary organics at a rate of at least about 10 to the 6th to 10 to the 7th kilograms per year, a flux that thereafter declined with a half-life of about 10 to the 8th years. These results may be put in context by comparison with terrestrial oceanic and total biomasses, about 3 x 10 to the 12th kilograms and about 6 x 10 to the 14th kilograms, respectively.

Spatial and Numerical Predictors of Measurement Performance: The Moderating Effects of Community Income and Gender

ERIC Educational Resources Information Center

Casey, Beth M.; Dearing, Eric; Vasilyeva, Marina; Ganley, Colleen M.; Tine, Michele

2011-01-01

Spatial reasoning and numerical predictors of measurement performance were investigated in 4th graders from low-income and affluent communities. Predictors of 2 subtypes of measurement performance (spatial-conceptual and formula based) were assessed while controlling for verbal and spatial working memory. Consistent with prior findings, students…

Inertial confinement fusion for energy: overview of the ongoing experimental, theoretical and numerical studies

NASA Astrophysics Data System (ADS)

Jacquemot, S.

2017-10-01

This paper provides an overview of the results presented at the 26th IAEA Fusion Energy Conference in the field of inertial confinement fusion for energy, covering its various experimental, numerical/theoretical and technological facets, as well as the different paths towards ignition that are currently followed worldwide.

Role of distinct CD4(+) T helper subset in pathogenesis of oral lichen planus.

PubMed

Wang, Hui; Zhang, Dunfang; Han, Qi; Zhao, Xin; Zeng, Xin; Xu, Yi; Sun, Zheng; Chen, Qianming

2016-07-01

Oral lichen planus (OLP) is one of the most common chronic inflammatory oral mucosal diseases with T-cell-mediated immune pathogenesis. In subepithelial and lamina propria of OLP local lesions, the presence of CD4(+) T helper (CD4(+) Th) cells appeared as the major lymphocytes. These CD4(+) T lymphocytes can differentiate into distinct Th cell types such as Th1, Th2, Treg, Th17, Th22, Th9, and Tfh within the context of certain cytokines environment. Growing evidence indicated that Th1/Th2 imbalance may greatly participate into the cytokine network of OLP immunopathology. In addition, Th1/Th2 imbalance can be regulated by the Treg subset and also greatly influenced by the emerging novel CD4(+) Th subset Th17. Furthermore, the presence of novel subsets Th22, Th9 and Tfh in OLP patients is yet to be clarified. All these Th subsets and their specific cytokines may play a critical role in determining the character, extent and duration of immune responses in OLP pathogenesis. Therefore, we review the roles of distinct CD4(+) Th subsets and their signature cytokines in determining disease severity and susceptibility of OLP and also reveal the novel therapeutic strategies based on T lymphocytes subsets in OLP treatment. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Recombinant human brain natriuretic peptide attenuates trauma-/haemorrhagic shock-induced acute lung injury through inhibiting oxidative stress and the NF-κB-dependent inflammatory/MMP-9 pathway.

PubMed

Song, Zhi; Zhao, Xiu; Liu, Martin; Jin, Hongxu; Wang, Ling; Hou, Mingxiao; Gao, Yan

2015-12-01

Acute lung injury (ALI) is one of the most serious complications in traumatic patients and is an important part of multiple organ dysfunction syndrome (MODS). Recombinant human brain natriuretic peptide (rhBNP) is a peptide with a wide range of biological activity. In this study, we investigated local changes in oxidative stress and the NF-κB-dependent matrix metalloproteinase-9 (MMP-9) pathway in rats with trauma/haemorrhagic shock (TH/S)-induced ALI and evaluated the effects of pretreatment with rhBNP. Forty-eight rats were randomly divided into four groups: sham operation group, model group, low-dosage rhBNP group and high-dosage rhBNP group (n = 12 for each group). Oxidative stress and MPO activity were measured by ELISA kits. MMP-9 activity was detected by zymography analysis. NF-κB activity was determined using Western blot assay. With rhBNP pretreatment, TH/S-induced protein leakage, increased MPO activity, lipid peroxidation and metalloproteinase (MMP)-9 activity were inhibited. Activation of antioxidative enzymes was reversed. The phosphorylation of NF-κB and the degradation of its inhibitor IκB were suppressed. The results suggested that the protection mechanism of rhBNP is possibly mediated through upregulation of anti-oxidative enzymes and inhibition of NF-κB activation. More studies are needed to further evaluate whether rhBNP is a suitable candidate as an effective inhaling drug to reduce the incidence of TH/S-induced ALI. © 2016 The Authors. International Journal of Experimental Pathology © 2016 International Journal of Experimental Pathology.

ITEM RESPONSE ANALYSES OF THE EDUCATIONAL OPPORTUNITIES SURVEY 9TH GRADE STUDENT QUESTIONNAIRE.

ERIC Educational Resources Information Center

WEINFELD, FREDERIC D.; AND OTHERS

THIS REPORT PRESENTS THE ANALYSIS OF QUESTIONNAIRE ITEM RESPONSES FROM THE NINTH-GRADE STUDENT QUESTIONNAIRE ADMINISTERED AS PART OF THE EDUCATIONAL OPPORTUNITIES SURVEY. THE ANALYSES WERE PERFORMED TO DOCUMENT SOME OF THE BASIC DATA FROM THE SURVEY, TO MAKE THEM AVAILABLE TO INTERESTED EDUCATIONAL RESEARCHERS, AND TO REWORK THE BASIC DATA FOR…

Technology and Language Testing. A Collection of Papers from the Annual Colloquium on Language Testing Research (7th, Princeton, New Jersey, April 6-9, 1985).

ERIC Educational Resources Information Center

Stansfield, Charles W., Ed.

This collection of essays on measurement theory and language testing includes: "Computerized Adaptive Testing: Implications for Language Test Developers" (Peter Tung); "The Promise and Threat of Computerized Adaptive Assessment of Reading Comprehension" (Michael Canale); "Computerized Rasch Analysis of Item Bias in ESL…

American Council on Consumer Interests Annual Conference Proceedings (34th, Chicago, Illinois, April 6-9, 1988).

ERIC Educational Resources Information Center

Hampton, Vickie L., Ed.

Among the 90 papers on topics relating to the consumer are "Academics and Advocates" (Brobeck); "Economic Profile of the Young and Elderly" (Ryscavage); "Estimation of Savings Needs To Adequately Fund Baby Boomers' Retirement" (Burns); "Saving and Dissaving in Retirement" (Hogarth); "Analysis of Effects of Children on Consumption and Savings…

The Impact of Teachers' Characteristics and Self-Reported Practices on Students' Algebra Achievement

ERIC Educational Resources Information Center

Cope, Liza M.

2013-01-01

This study examined the impact of teachers' characteristics and self-reported practices on students' Algebra achievement while controlling for students' characteristics. This study is based on the secondary analysis of data collected from a nationally representative sample of 9 th grade students and their mathematics teachers during…

Life-Metaphors among Colombian Medical Students: Uncovering Core Values and Educational Implications

ERIC Educational Resources Information Center

Hoffman, Edward; Acosta-Orozco, Catalina; Compton, William C.

2015-01-01

The present study utilized metaphor analysis to examine the core values of Colombian medical students. The entire 9th semester medical class of 60 students was invited to respond to a structured questionnaire. It asked participants to state their preferred life-metaphor, whether they had always preferred this metaphor since childhood or…

Time Series Analysis of Water Level and Temperature in the St Louis River Estuary

EPA Science Inventory

Pressure and temperature loggers were deployed at 9 sites in the St Louis River estuary between 6/23 10/31 2011. A reference sensor was place on the shore to correct pressure data. Sensors were paced at <1 m depth in Allouez Bay, Superior Bay, near Hearding Island, WLSSD Bay, th...

76 FR 63664 - Arts Advisory Panel

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-13

... 4th, will be closed. Music (application review): November 1-3, 2011 in Room 714. This meeting, from 9... from 9 a.m. to 2 p.m. on November 17th, will be closed. Music (application review): November 15-18...

78 FR 31633 - Meeting of Citizen Coinage Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

... public may attend the meeting at the United States Mint, 801 9th Street NW., Washington, DC, Conference..., United States Mint Liaison to the CCAC; 801 9th Street NW., Washington, DC 20220; or call 202-354-7200...

Communication skills and self-esteem in prevention of destructive behaviors.

PubMed

Englander-Golden, P; Jackson, J E; Crane, K; Schwarzkopf, A B; Lyle, P S

1989-01-01

This study demonstrates the long-range effectiveness of SAY IT STRAIGHT training as a school-based program for the prevention of destructive behaviors by comparing juvenile police offenders among trained and untrained 9th-12th graders for 1 1/2 years following training. In the 1984-85 school year, 357 of the 740 9th-12th graders in a southwestern town completed SAY IT STRAIGHT training. Participation was voluntary and required parental permission. During a five-month pretraining period which began with the first day of school, the number of juvenile police offenders was not significantly different among students who would eventually be trained or not be trained. During the following 7 months including summer vacation, there were significantly fewer offenders among the trained students. The following school year and summer vacation there were again significantly fewer offenders among the trained students. During the whole 1 1/2-year study, the untrained students had about 4.5 times as many criminal offenses as the trained students and their offenses were more severe. Finally, 9th, 10th, and 12th graders as well as 11th-grade females who had been trained showed a significant shift toward behavioral intentions reflecting a greater willingness to implement their constructive decisions and feel comfortable doing so. This study extends the applicability of SAY IT STRAIGHT training which previously has been reported to significantly reduce alcohol/drug-related school suspensions among 6th-8th graders.

High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program

PubMed Central

Zhou, Xiao-Yang; Zhu, Fa-Ming; Li, Jian-Ping; Mao, Wei; Zhang, De-Mei; Liu, Meng-Li; Hei, Ai-Lian; Dai, Da-Peng; Jiang, Ping; Shan, Xiao-Yan; Zhang, Bo-Wei; Zhu, Chuan-Fu; Shen, Jie; Deng, Zhi-Hui; Wang, Zheng-Lei; Yu, Wei-Jian; Chen, Qiang; Qiao, Yan-Hui; Zhu, Xiang-Ming; Lv, Rong; Li, Guo-Ying; Li, Guo-Liang; Li, Heng-Cong; Zhang, Xu; Pei, Bin; Jiao, Li-Xin; Shen, Gang; Liu, Ying; Feng, Zhi-Hui; Su, Yu-Ping; Xu, Zhao-Xia; Di, Wen-Ying; Jiang, Yao-Qin; Fu, Hong-Lei; Liu, Xiang-Jun; Liu, Xiang; Zhou, Mei-Zhen; Du, Dan; Liu, Qi; Han, Ying; Zhang, Zhi-Xin; Cai, Jian-Ping

2015-01-01

Allogeneic hematopoietic stem cell transplantation is a widely used and effective therapy for hematopoietic malignant diseases and numerous other disorders. High-resolution human leukocyte antigen (HLA) haplotype frequency distributions not only facilitate individual donor searches but also determine the probability with which a particular patient can find HLA-matched donors in a registry. The frequencies of the HLA-A, -B, -C, -DRB1, and -DQB1 alleles and haplotypes were estimated among 169,995 Chinese volunteers using the sequencing-based typing (SBT) method. Totals of 191 HLA-A, 244 HLA-B, 146 HLA-C, 143 HLA-DRB1 and 47 HLA-DQB1 alleles were observed, which accounted for 6.98%, 7.06%, 6.46%, 9.11% and 7.91%, respectively, of the alleles in each locus in the world (IMGT 3.16 Release, Apr. 2014). Among the 100 most common haplotypes from the 169,995 individuals, nine distinct haplotypes displayed significant regionally specific distributions. Among these, three were predominant in the South China region (i.e., the 20th, 31st, and 81sthaplotypes), another three were predominant in the Southwest China region (i.e., the 68th, 79th, and 95th haplotypes), one was predominant in the South and Southwest China regions (the 18th haplotype), one was relatively common in the Northeast and North China regions (the 94th haplotype), and one was common in the Northeast, North and Northwest China (the 40th haplotype). In conclusion, this is the first to analyze high-resolution HLA diversities across the entire country of China, based on a detailed and complete data set that covered 31 provinces, autonomous regions, and municipalities. Specifically, we also evaluated the HLA matching probabilities within and between geographic regions and analyzed the regional differences in the HLA diversities in China. We believe that the data presented in this study might be useful for unrelated HLA-matched donor searches, donor registry planning, population genetic studies, and anthropogenesis studies. PMID:26421847

Analysis of correlation between corneal topographical data and visual performance

NASA Astrophysics Data System (ADS)

Zhou, Chuanqing; Yu, Lei; Ren, Qiushi

2007-02-01

Purpose: To study correlation among corneal asphericity, higher-order aberrations and visual performance for eyes of virgin myopia and postoperative laser in situ keratomileusis (LASIK). Methods: There were 320 candidates 590 eyes for LASIK treatment included in this study. The mean preoperative spherical equivalence was -4.35+/-1.51D (-1.25 to -9.75), with astigmatism less than 2.5 D. Corneal topography maps and contrast sensitivity were measured and analyzed for every eye before and one year after LASIK for the analysis of corneal asphericity and wavefront aberrations. Results: Preoperatively, only 4th and 6th order aberration had significant correlation with corneal asphericity and apical radius of curvature (p<0.001). Postoperatively, all 3th to 6th order aberrations had statistically significant correlation with corneal asphericity (p<0.01), but only 4th and 6th order aberration had significant correlation with apical radius of curvature (p<0.05). The asymmetrical aberration like coma had significant correlation with vertical offset of pupil center (p<0.01). Preoperatively, corneal aberrations had no significant correlation with visual acuity and area under the log contrast sensitivity (AULCSF) (P>0.05). Postoperatively, corneal aberrations still didn't have significant correlation with visual acuity (P>0.05), but had significantly negative correlation with AULCSF (P<0.01). Corneal asphericity had no significant correlation with AULCSF before and after the treatment (P>0.05). Conclusions: Corneal aberrations had different correlation with corneal profile and visual performance for eyes of virgin myopia and postoperative LASIK, which may be due to changed corneal profile and limitation of metrics of corneal aberrations.

Gender differences in food preferences of school-aged children and adolescents.

PubMed

Caine-Bish, Natalie L; Scheule, Barbara

2009-11-01

Schools have the opportunity, through the National School Lunch Program and Local School Wellness Policies, to have a significant impact on healthy eating behaviors. An understanding of children's and adolescents' food preferences in relation to gender and age will facilitate the successful creation of both healthy and financially viable school menus. The purpose of this study was to identify food preferences with respect to gender of school-age children and adolescents in an Ohio school district. A survey was administered to 1818 3rd- to 12th-grade students in 1 rural northeast Ohio school district. Students filled out an anonymous questionnaire about their preferences for 80 different foods using a 5-point rating scale. The student data were grouped according to school level attended: elementary (3rd-6th), middle (7th-8th), and high school (9th-12th). An exploratory factor analysis identified entrée and side dish factors. Cronbach's alpha was used to measure each factor's internal reliability. Differences in mean scores by gender and grade for each of the entrée and side dish factors by gender and grade were identified using analysis of variance (ANOVA). Boys preferred the meat, fish, and poultry foods over girls; girls preferred fruits and vegetables over boys (p < .05). Furthermore, gender differences in preferences were also demonstrated with respect to school level. Food preferences differed between genders and these gender differences varied among elementary, middle, and high school students. Gender differences should be considered when providing food choices to boys and girls at all ages.

Thorium, uranium and rare earth elements content in lanthanide concentrate (LC) and water leach purification (WLP) residue of Lynas advanced materials plant (LAMP)

NASA Astrophysics Data System (ADS)

AL-Areqi, Wadeeah M.; Majid, Amran Ab.; Sarmani, Sukiman

2014-02-01

Lynas Advanced Materials Plant (LAMP) has been licensed to produce the rare earths elements since early 2013 in Malaysia. LAMP processes lanthanide concentrate (LC) to extract rare earth elements and subsequently produce large volumes of water leach purification (WLP) residue containing naturally occurring radioactive material (NORM). This residue has been rising up the environmental issue because it was suspected to accumulate thorium with significant activity concentration and has been classified as radioactive residue. The aim of this study is to determine Th-232, U-238 and rare earth elements in lanthanide concentrate (LC) and water leach purification (WLP) residue collected from LAMP and to evaluate the potential radiological impacts of the WLP residue on the environment. Instrumental Neutron Activation Analysis and γ-spectrometry were used for determination of Th, U and rare earth elements concentrations. The results of this study found that the concentration of Th in LC was 1289.7 ± 129 ppm (5274.9 ± 527.6Bq/kg) whereas the Th and U concentrations in WLP were determined to be 1952.9±17.6 ppm (7987.4 ± 71.9 Bq/kg) and 17.2 ± 2.4 ppm respectively. The concentrations of Th and U in LC and WLP samples determined by γ- spectrometry were 1156 ppm (4728 ± 22 Bq/kg) & 18.8 ppm and 1763.2 ppm (7211.4 Bq/kg) &29.97 ppm respectively. This study showed that thorium concentrations were higher in WLP compare to LC. This study also indicate that WLP residue has high radioactivity of 232Th compared to Malaysian soil natural background (63 - 110 Bq/kg) and come under preview of Act 304 and regulations. In LC, the Ce and Nd concentrations determined by INAA were 13.2 ± 0.6% and 4.7 ± 0.1% respectively whereas the concentrations of La, Ce, Nd and Sm in WLP were 0.36 ± 0.04%, 1.6%, 0.22% and 0.06% respectively. This result showed that some amount of rare earth had not been extracted and remained in the WLP and may be considered to be reextracted.

[Effect of static magnetic field on deep wound healing of SD rats].

PubMed

Shen, Jian-Guo; Chen, Wei-Shan; Wang, Chang-Xing; Jiang, Tao; Dong, Li-Qiang

2009-05-01

To investigate the effect of static magnetic field on deep wound healing of SD rats and VEGF during the wound healing and different strength static magnetic field on deep wound healing of SD rats. Divided forty-eight SD rats into three groups: 0.16 T magnetic disk treatment (0.16 T group), 0.32 T magnetic disk treatment (0.32 T group), control group. General wounds healing situation was observated on the 3, 6, 9, 12 day. The area of every wound was calculated. The tissue of granulation was dyeing by immune tissue chemical decoration method, in which VEGF protein content with its range in tissue was measured. The healing index of 0.16 T magnetic group wounds were larger than that of control group on 6th and 9th day, there were statistical difference. The healing index of 0.32 T magnetic group wounds were larger than that of control group on 3rd, 6th, 9th and 12th day, there were statistical difference. The healing index of 0.32 T group wounds contrasted to that of 0.16 T group wounds had no statistical significance. Observation of VEGF at the course of wound healing:the expressing of VEGF in magnetic group wounds on 3rd and 6th was stronger than in control group wounds, there were statistical difference. While there were no obvious difference between them on 9th and 12th day (P>0.05). But the contrast between that in 0.32 T group and in 0.16 T group had no statistical difference. The expressing strength of VEGF in magnetic group reached the peak amplitude on the 6th day, and that in control group reached peak amplitude on 9th day. And the peak amplitude of magnetic group was stronger than that of control group. Static magnetic disc of 0.16T and 0.32 T can promote deep wound of SD rats heal. The mechanism of static magnetic field promoting wound heal may be relative to the expressing highly of VEGF during early and middle time.

Creepy Critters (Snakes). [Aids to Individualize the Teaching of Science, Mini-Course Units for Grades 7, 8, and 9.

ERIC Educational Resources Information Center

Best, Terrence

This booklet, one of a series developed by the Frederick County Board of Education, Frederick, Maryland, provides an instruction module for an individualized or flexible approach to 7th, 8th, and 9th grade science teaching. Subjects and activities in this series of booklets are designed to supplement a basic curriculum or to form a total…

Closing the Performance Gap: The Impact of the Early College High School Model on Underprepared Students

ERIC Educational Resources Information Center

Bernstein, Larry; Edmunds, Julie; Fesler, Lily

2014-01-01

Students entering high school in 9th grade face a formidable challenge. The transition to high school from 8th grade brings with it increased risks for all students. For example, students in 9th grade are anywhere from three to five times more likely to fail a class than students in any other grade. Similarly, ninth grade retention rates are…

Protist: The "Unseen" Kingdom. [Aids to Individualize the Teaching of Science, Mini-Course Units for Grades 7, 8, and 9.

ERIC Educational Resources Information Center

Whitfield, Melvin

This booklet, one of a series developed by the Frederick County Board of Education, Frederick, Maryland, provides an instruction module for an individualized or flexible approach to 7th, 8th, and 9th grade science teaching. Subjects and activities in this series of booklets are designed to supplement a basic curriculum or to form a total…

Aloha Teachers: Teacher Autonomy Support Promotes Native Hawaiian and Pacific Islander Students' Motivation, School Belonging, Course-Taking and Math Achievement

ERIC Educational Resources Information Center

Froiland, John Mark; Davison, Mark L.; Worrell, Frank C.

2016-01-01

Among 110 Native Hawaiians and Pacific Islanders, teacher autonomy support in 9th grade significantly predicted intrinsic motivation for math in 9th grade as well as math course-taking over the next 2 years, both of which in turn significantly predicted math achievement by 11th grade. In a second model, teacher autonomy support was positively…

Energy in the Global Marketplace. Grades 9, 10, 11. Interdisciplinary Student/Teacher Materials in Energy, the Environment, and the Economy.

ERIC Educational Resources Information Center

National Science Teachers Association, Washington, DC.

This instructional unit contains six classroom lessons in which 9th, 10th, or 11th grade social studies students examine the effects of competition among nations and world regions as demand for oil outstrips supply. The overall objective is to help students understand the concept that energy is a commodity to be bought and sold like any other…

Space and Its Problems. [Aids to Individualize the Teaching of Science, Mini-Course Units for Grades 7, 8, and 9.

ERIC Educational Resources Information Center

Geist, John E.

This booklet, one of a series developed by the Frederick County Board of Education, Frederick, Maryland, provides an instruction module for an individualized or flexible approach to 7th, 8th, and 9th grade science teaching. Subjects and activities in this series of booklets are designed to supplement a basic curriculum or to form a total…

Guess Who's Been Here for Dinner? [Aids to Individualize the Teaching of Science, Mini-Course Units for Grades 7, 8, and 9.

ERIC Educational Resources Information Center

Cook, Paul

This booklet, one of a series developed by the Frederick County Board of Education, Frederick, Maryland, provides an instruction module for an individualized or flexible approach to 7th, 8th, and 9th grade science teaching. Subjects and activities in this series of booklets are designed to supplement a basic curriculum or to form a total…

Engaging Minds. Proceedings of the National Academy for Integration of Research, Teaching and Learning Annual Conference (5th, Galway, Ireland, June 9-10, 2011)

ERIC Educational Resources Information Center

National Academy for Integration of Research, Teaching and Learning (NJ1), 2011

2011-01-01

This publication contains the papers presented at the 5th Annual Conference of National Academy for Integration of Research, Teaching and Learning (NAIRTL) and the 9th Galway Symposium. Presenters from across Ireland and overseas share their perspectives. The theme of engagement touches on the very heart of what a "higher" education…

Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets.

PubMed

Czarnowicki, Tali; Esaki, Hitokazu; Gonzalez, Juana; Malajian, Dana; Shemer, Avner; Noda, Shinji; Talasila, Sreya; Berry, Adam; Gray, Jayla; Becker, Lauren; Estrada, Yeriel; Xu, Hui; Zheng, Xiuzhong; Suárez-Fariñas, Mayte; Krueger, James G; Paller, Amy S; Guttman-Yassky, Emma

2015-10-01

Identifying differences and similarities between cutaneous lymphocyte antigen (CLA)(+) polarized T-cell subsets in children versus adults with atopic dermatitis (AD) is critical for directing new treatments toward children. We sought to compare activation markers and frequencies of skin-homing (CLA(+)) versus systemic (CLA(-)) "polar" CD4 and CD8 T-cell subsets in patients with early pediatric AD, adults with AD, and control subjects. Flow cytometry was used to measure CD69/inducible costimulator/HLA-DR frequency in memory cell subsets, as well as IFN-γ, IL-13, IL-9, IL-17, and IL-22 cytokines, defining TH1/cytotoxic T (TC) 1, TH2/TC2, TH9/TC9, TH17/TC17, and TH22/TC22 populations in CD4 and CD8 cells, respectively. We compared peripheral blood from 19 children less than 5 years old and 42 adults with well-characterized moderate-to-severe AD, as well as age-matched control subjects (17 children and 25 adults). Selective inducible costimulator activation (P < .001) was seen in children. CLA(+) TH2 T cells were markedly expanded in both children and adults with AD compared with those in control subjects, but decreases in CLA(+) TH1 T-cell numbers were greater in children with AD (17% vs 7.4%, P = .007). Unlike in adults, no imbalances were detected in CLA(-) T cells from pediatric patients with AD nor were there altered frequencies of TH22 T cells within the CLA(+) or CLA(-) compartments. Adults with AD had increased frequencies of IL-22-producing CD4 and CD8 T cells within the skin-homing population, compared with controls (9.5% vs 4.5% and 8.6% vs 2.4%, respectively; P < .001), as well as increased HLA-DR activation (P < .01). These data suggest that TH2 activation within skin-homing T cells might drive AD in children and that reduced counterregulation by TH1 T cells might contribute to excess TH2 activation. TH22 "spreading" of AD is not seen in young children and might be influenced by immune development, disease chronicity, or recurrent skin infections. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Cerebrospinal Fluid Glucose and Lactate: Age-Specific Reference Values and Implications for Clinical Practice

PubMed Central

Leen, Wilhelmina G.; Willemsen, Michèl A.; Wevers, Ron A.; Verbeek, Marcel M.

2012-01-01

Cerebrospinal fluid (CSF) analysis is an important tool in the diagnostic work-up of many neurological disorders, but reference ranges for CSF glucose, CSF/plasma glucose ratio and CSF lactate based on studies with large numbers of CSF samples are not available. Our aim was to define age-specific reference values. In 1993 The Nijmegen Observational CSF Study was started. Results of all CSF samples that were analyzed between 1993 and 2008 at our laboratory were systematically collected and stored in our computerized database. After exclusion of CSF samples with an unknown or elevated erythrocyte count, an elevated leucocyte count, elevated concentrations of bilirubin, free hemoglobin, or total protein 9,036 CSF samples were further studied for CSF glucose (n = 8,871), CSF/plasma glucose ratio (n = 4,516) and CSF lactate values (n = 7,614). CSF glucose, CSF/plasma glucose ratio and CSF lactate were age-, but not sex dependent. Age-specific reference ranges were defined as 5–95th percentile ranges. CSF glucose 5th percentile values ranged from 1.8 to 2.9 mmol/L and 95th percentile values from 3.8 to 5.6 mmol/L. CSF/plasma glucose ratio 5th percentile values ranged from 0.41 to 0.53 and 95th percentile values from 0.82 to 1.19. CSF lactate 5th percentile values ranged from 0.88 to 1.41 mmol/L and 95th percentile values from 2.00 to 2.71 mmol/L. Reference ranges for all three parameters were widest in neonates and narrowest in toddlers, with lower and upper limits increasing with age. These reference values allow a reliable interpretation of CSF results in everyday clinical practice. Furthermore, hypoglycemia was associated with an increased CSF/plasma glucose ratio, whereas hyperglycemia did not affect the CSF/plasma glucose ratio. PMID:22880096

Interpretation of time series (salinity and temperature) layers in North Atlantic from 1950 to 2011

NASA Astrophysics Data System (ADS)

Rubchenia, A.; Popov, A.; Fedorova, A.; Lebedev, N.

2012-04-01

On the basis of long period data series (1950-2011) form various sources (National Oceanographic Data Center (NOAD) (www.nodc.noaa.gov), WOD09 database and data from ARGO project) 10 boxes in North Atlantic were selected. Location of boxes was determined by circulation pattern in North Atlantic and Euro-Arctic Seas. For further analysis two "seasons" was selected: "cold season" (October-May) and "warm season" (June-September). Data verification was made. Analysis of data series clearly show the "Great Salinity Anomaly" (so-called GSA) in 1960-70th, 1980th and 1990th. Trends of salinity and temperature data series were calculated. Spectral analysis allow us to calculate periodicity from 2 to 22 years. Boxes situated in regions with Arctic waters have singularity showed through domination of high frequency oscillation during propagation to South. In Fram Strait salinity fluctuates with periods 9..11 and 20 years, the same period was calculated using temperature data series. In Denmark Strait there are oscillations of temperature with specific period from 4 to 7 years. Range of variability vary. For salinity it is 0.4..4.6 psu, for temperature it is 0.04..5.5C. In salinity data series from boxes with surface Arctic waters noticed clear minimums connected with GSAs. Trends in Denmark Strait and Fram strait in the end of 2000th are negative at different levels. Since 1975 to 2001 salinity near the southern part of Greenland was increased, since 2001 - decreased. But temperature was raised from 0.04 in 1989 to 5.59 in 2010. Thermohaline characteristics of water masses which has Atlantic origin oscillated with period near 20 years. Salinity near Newfoundland was decreased since 2005. In Farrero-Shetland straits salinity trend is positive since at 100m level, Salinity rising from 1970th to 2006 is about 0.3 psu were noticed. Oscillations with period 2..4 years is weak. But at 800m layer salinity oscillations are different, since 1990 there is not significant oscillations at all. Temperature trend at this level is negative since 1950th. Salinity at 100-300 level at Station M area described with negative trend since 1960 to 1993, in both "seasons". Next, up to 2010 salinity is increasing, but in 2011 salinity dramatically decreased. Main oscillations have periods 2..3 years, 4..5 years and 20 years. At 800m level oscillations are very weak. Temperature is increased since 1995 in surface layer and since 2002 in deeper levels. At all levels temperature dramatically decreased after 2010. In central part of Greenland Sea ("Cupola area") dominated oscillations with period 4 years (1950-60th), 5..7 years (1970th) and 9 years (after 1979). In "cold season" oscillation with 11 years traced. Salinity trend is positive at all levels during last 10-15 years. Salinity and temperature were increased at 800m level up to 2006. It could lead to termination of deep water formation. Since 2006 temperature decreased, especially in "cold season". Salinity trend in West Spitsbergen Current is positive since 1996 at surface and sine 1978 at deeper levels. Temperature was increased since 1965 to 2006 in surface layer, but since 2006 in "warm season" temperature is decreasing at all layers. Main oscillations is 4..5 years, 6..7 years and 9..11 years.

Analysis of Strain Dependent Damping in Materials via Modeling of Material Point Hysteresis

DTIC Science & Technology

1991-07-01

Read input quantities fromi input files. C RBAD(9:5STIi’LE RM(q.A)-)’)SY READ (9, -’(X)’-) RP.AD(9,’jA) ’)SN RFPD(9, ’(A)’ ) SALP 5 FOR.%MT(A) REA" (9...IBSN,IESK) CALL ShLRLN( SALP , IBSAL?, IESALP?) CALL SThLEN( BA, ThSA, IESA) CALL STRLEN(SYT,ZBSFT,J:ESFT) CA*LL STRLEN (Sa~l, IBSARI, IMSAM~) CALL STRI2N...CHAP.ACTER-󈨊 TITLE,SYS,SG,SN, SALP ,SGO,SGP,SA,SI’T CU1RXCT2R- ( ) SARI, SAýR2 ,SAR3, SAR4, SARS, SARI, SAR7,SARP PARAMETER (SARl-’g0-’) PARAMETPR (SAR2""Ys

13th Central Hardwoods Forest Conference

Treesearch

J.W. Van Sambeek; Jeffrey O. Dawson; Felix Jr Ponder; Edward F. Loewenstein; James S. Fralish

2003-01-01

This conference was the 13th in a series of biennial meetings that have been hosted by numerous universities and research stations of the USDA Forest Service in the Central Hardwood forest region in the eastern United States. The purpose of the Conference has remained the same since it's inception -- that is to provide a forum for the formal and informal exchange...

Variation in chromosome constitution of the Xiaoyan series partial amphiploids and its relations to stripe rust and stem rust resistance

USDA-ARS?s Scientific Manuscript database

In the tertiary gene pool of wheat, tall wheatgrass Thinopyrum ponticum (2n = 10x = 70) is an excellent source of resistance genes against numerous wheat diseases. The creation of wheat-Th. ponticum partial amphiploids is an intermediate step for transferring the useful genes from Th. ponticum to w...

Genitourinary Surgical Workload at Deployed U.S. Facilities in Iraq and Afghanistan, 2002-2016.

PubMed

Turner, Caryn A; Orman, Jean A; Stockinger, Zsolt T; Hudak, Steven J

2018-06-13

Genitourinary surgery constitutes approximately 1.15% of procedures performed for combat injuries. During forward deployment, surgeons usually deploy without urology support. To better understand the training and skills maintenance needs for genitourinary procedures by describing in detail the genitourinary surgical workload during 15 years of combat operations and compare our findings with those from previously published articles. A retrospective analysis of the Department of Defense Trauma Registry (DoDTR) was performed for all Roles 2 and 3 medical treatment facilities in Iraq and Afghanistan, from January 2002 to May 2016. The 177 ICD-9-CM procedure codes identified as genitourinary procedures were grouped into 15 anatomic categories by subject matter experts. Select groups were further subdivided by procedure types. Descriptive analyses were performed and stratified workload percentiles were calculated for the 10th, 50th, and 90th percentiles. Data analysis was performed using Stata Version 14 (College Station, TX, USA). This quality improvement project was deemed exempt from institutional review board review by the U.S. Army Institute of Surgical Research. A total of 3,963 genitourinary surgical procedures were identified, the majority occurring at Role 3 medical treatment facilities (3,512, 88.6%). The most common procedure groups were testis (20.6%), bladder (18.8%), scrotum (17.7%), and kidney (13.5%). The single most common individual procedures performed were unilateral orchiectomy (394, 9.9%), suture of laceration of scrotum and tunica vaginalis (373, 9.4%), nephroureterectomy (360, 9.1%), and other suprapubic cystostomy (268, 6.8%). Of the 77 gynecological procedures, 15 were C-sections. Genitourinary caseload per facility was low, never exceeding nine procedures per month. All deploying surgeons may be required to evaluate, stage, and surgically manage genitourinary, gynecologic, and obstetrical conditions. Surgery on the male genitalia, bladder, and kidney were the most commonly required genitourinary operative procedures in deployed facilities; therefore, non-urological surgeons should receive pre-deployment training in these techniques. The workload data from our study can be used to help guide the development of pre-deployment training to ensure military surgeons have the skills to perform the specialty procedures required while deployed.

[Effect of pamidronate and ibandronate on orthodontic root resorption in rats].

PubMed

Zhao, Shu-ya; Wang, Xu-xia; Liu, Wan-xin; Dong, Rui; Li, Jing; Zhang, Jun

2013-09-01

To compare the effects of pamidronate and ibandronate on orthodontic root resorption. Seventy-two 6-week-old female specific pathogen free (SPF) Wistar rats were selected to establish models for orthodontic tooth movement. The rats were randomly divided into three groups: the control group (C group), pamidronate group (Pm group) and ibandronate group (Ib group). 0.9% normal saline,0.5 mmol/L pamidronate and 0.5 mmol/L ibandronate were injected every 3 days. The rats were executed in batch on the 3rd, 7th and 14th day to make tissue sections. All statistical analysis was performed using the PASW Statistics 18 software package. On the 7th and 14th day, the amount of cementoclast, the expression of osteoclast differentiation factor (ODF) and root resorption index were significantly lower in Pm group [the 7th day: (2.675 ± 0.002), (0.1683 ± 0.0007), (0.103 ± 0.003); the 14th day: (3.886 ± 0.048), (0.1873 ± 0.0014), (0.283 ± 0.001)] and Ib groups[the 7th day: (2.601 ± 0.001), (0.1634 ± 0.0010), (0.099 ± 0.002); the 14th day: (3.754 ± 0.019), (0.1818 ± 0.0016), (0.281 ± 0.001)] than in C group[the 7th day: (2.810 ± 0.001), (0.1792 ± 0.0008), (0.120 ± 0.001); the 14th day: (4.800 ± 0.001), (0.2060 ± 0.0007), (0.401 ± 0.001)] (P < 0.05). However, no significant difference was found between Pm and Ib groups on the 3rd, 7th and 14th day (P > 0.05). Both pamidronate and ibandronate could inhibit orthodontic root resorption.

Investigating the usefulness of a cluster-based trend analysis to detect visual field progression in patients with open-angle glaucoma.

PubMed

Aoki, Shuichiro; Murata, Hiroshi; Fujino, Yuri; Matsuura, Masato; Miki, Atsuya; Tanito, Masaki; Mizoue, Shiro; Mori, Kazuhiko; Suzuki, Katsuyoshi; Yamashita, Takehiro; Kashiwagi, Kenji; Hirasawa, Kazunori; Shoji, Nobuyuki; Asaoka, Ryo

2017-12-01

To investigate the usefulness of the Octopus (Haag-Streit) EyeSuite's cluster trend analysis in glaucoma. Ten visual fields (VFs) with the Humphrey Field Analyzer (Carl Zeiss Meditec), spanning 7.7 years on average were obtained from 728 eyes of 475 primary open angle glaucoma patients. Mean total deviation (mTD) trend analysis and EyeSuite's cluster trend analysis were performed on various series of VFs (from 1st to 10th: VF1-10 to 6th to 10th: VF6-10). The results of the cluster-based trend analysis, based on different lengths of VF series, were compared against mTD trend analysis. Cluster-based trend analysis and mTD trend analysis results were significantly associated in all clusters and with all lengths of VF series. Between 21.2% and 45.9% (depending on VF series length and location) of clusters were deemed to progress when the mTD trend analysis suggested no progression. On the other hand, 4.8% of eyes were observed to progress using the mTD trend analysis when cluster trend analysis suggested no progression in any two (or more) clusters. Whole field trend analysis can miss local VF progression. Cluster trend analysis appears as robust as mTD trend analysis and useful to assess both sectorial and whole field progression. Cluster-based trend analyses, in particular the definition of two or more progressing cluster, may help clinicians to detect glaucomatous progression in a timelier manner than using a whole field trend analysis, without significantly compromising specificity. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Readability assessment of internet-based patient education materials related to facial fractures.

PubMed

Sanghvi, Saurin; Cherla, Deepa V; Shukla, Pratik A; Eloy, Jean Anderson

2012-09-01

Various professional societies, clinical practices, hospitals, and health care-related Web sites provide Internet-based patient education material (IPEMs) to the general public. However, this information may be written above the 6th-grade reading level recommended by the US Department of Health and Human Services. The purpose of this study is to assess the readability of facial fracture (FF)-related IPEMs and compare readability levels of IPEMs provided by four sources: professional societies, clinical practices, hospitals, and miscellaneous sources. Analysis of IPEMs on FFs available on Google.com. The readability of 41 FF-related IPEMs was assessed with four readability indices: Flesch-Kincaid Grade Level (FKGL), Flesch Reading Ease Score (FRES), Simple Measure of Gobbledygook (SMOG), and Gunning Frequency of Gobbledygook (Gunning FOG). Averages were evaluated against national recommendations and between each source using analysis of variance and t tests. Only 4.9% of IPEMs were written at or below the 6th-grade reading level, based on FKGL. The mean readability scores were: FRES 54.10, FKGL 9.89, SMOG 12.73, and Gunning FOG 12.98, translating into FF-related IPEMs being written at a "difficult" writing level, which is above the level of reading understanding of the average American adult. IPEMs related to FFs are written above the recommended 6th-grade reading level. Consequently, this information would be difficult to understand by the average US patient. Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.

Health Literacy: Readability of ACC/AHA Online Patient Education Material.

PubMed

Kapoor, Karan; George, Praveen; Evans, Matthew C; Miller, Weldon J; Liu, Stanley S

To determine whether the online patient education material offered by the American College of Cardiology (ACC) and the American Heart Association (AHA) is written at a higher level than the 6th-7th grade level recommended by the National Institute of Health (NIH). Online patient education material from each website was subjected to reading grade level (RGL) analysis using the Readability Studio Professional Edition. One-sample t testing was used to compare the mean RGLs obtained from 8 formulas to the NIH-recommended 6.5 grade level and 8th grade national mean. In total, 372 articles from the ACC website and 82 from the AHA were studied. Mean (±SD) RGLs for the 454 articles were 9.6 ± 2.1, 11.2 ± 2.1, 11.9 ± 1.6, 10.8 ± 1.6, 9.7 ± 2.1, 10.8 ± 0.8, 10.5 ± 2.6, and 11.7 ± 3.5 according to the Flesch-Kincaid grade level (FKGL), Simple Measure of Gobbledygook (SMOG Index), Coleman-Liau Index (CLI), Gunning-Fog Index (GFI), New Dale-Chall reading level formula (NDC), FORCAST, Raygor Readability Estimate (RRE), and Fry Graph (Fry), respectively. All analyzed articles had significantly higher RGLs than both the NIH-recommended grade level of 6.5 and the national mean grade level of 8 (p < 0.00625). Patient education material provided on the ACC and AHA websites is written above the NIH-recommended 6.5 grade level and 8th grade national mean reading level. Additional studies are required to demonstrate whether lowering the RGL of this material improves outcomes among patients with cardiovascular disease. © 2017 S. Karger AG, Basel.

Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice

PubMed Central

Ohba, Kenji; Singh, Brijesh Kumar; Sinha, Rohit Anthony; Lesmana, Ronny; Liao, Xiao-Hui; Ghosh, Sujoy; Refetoff, Samuel

2016-01-01

Clinical symptoms may vary and not necessarily reflect serum thyroid hormone (TH) levels during acute and chronic hyperthyroidism as well as recovery from hyperthyroidism. We thus examined changes in hepatic gene expression and serum TH/TSH levels in adult male mice treated either with a single T3 (20 μg per 100 g body weight) injection (acute T3) or daily injections for 14 days (chronic T3) followed by 10 days of withdrawal. Gene expression arrays from livers harvested at these time points showed that among positively-regulated target genes, 320 were stimulated acutely and 429 chronically by T3. Surprisingly, only 69 of 680 genes (10.1%) were induced during both periods, suggesting desensitization of the majority of acutely stimulated target genes. About 90% of positively regulated target genes returned to baseline expression levels after 10 days of withdrawal; however, 67 of 680 (9.9%) did not return to baseline despite normalization of serum TH/TSH levels. Similar findings also were observed for negatively regulated target genes. Chromatin immunoprecipitation analysis of representative positively regulated target genes suggested that acetylation of H3K9/K14 was associated with acute stimulation, whereas trimethylation of H3K4 was associated with chronic stimulation. In an in vivo model of chronic intrahepatic hyperthyroidism since birth, adult male monocarboxylate transporter-8 knockout mice also demonstrated desensitization of most acutely stimulated target genes that were examined. In summary, we have identified transcriptional desensitization and incomplete recovery of gene expression during chronic hyperthyroidism and recovery. Our findings may be a potential reason for discordance between clinical symptoms and serum TH levels observed in these conditions. PMID:26866609

A Static Aeroelastic Analysis of a Flexible Wing Mini Unmanned Aerial Vehicle

DTIC Science & Technology

2008-03-27

is the most favorable because it generally results in the greatest CL max and is less prone to hysteresis in the lift curve. Carmichael emphasized the...Defense, 2005. 8. Carmichael B. H. Low Reynolds Number Airfoil Survey . Technical Report, NASA, 1981. 9. Crabtree L. F. “Effects of Leading-Edge Separation...44th AIAA Aerospace Sciences Meeting and Exhibit . Jan 2006. 34. Stults J. A. Computational Aeroelastic Analysis of Micro Air Vehicle with Ex

Peer sexual harassment and disordered eating in early adolescence.

PubMed

Petersen, Jennifer L; Hyde, Janet S

2013-01-01

Peer sexual harassment is a pervasive problem in schools and is associated with a variety of negative mental health outcomes. Objectification theory suggests that sexual attention in the form of peer harassment directs unwanted attention to the victim's body and may lead to a desire to alter the body via disordered eating. In the current study, we used latent growth modeling with a sample of 406 U.S. adolescents to examine the relationship between longitudinal trends in peer sexual harassment from 5th to 9th grade and disordered eating in 9th grade. Longitudinal trends in self-surveillance were proposed as a mediator of the relationships. Results indicated that the relationship between upsetting sexual harassment at 5th grade and disordered eating symptoms at 9th grade was mediated by self-surveillance at 5th grade. Girls reported more upsetting sexual harassment, more self-surveillance, and thus more disordered eating than boys did. These results are in accord with objectification theory, which proposes that sexual harassment is a form of sexual objectification and may lead to self-surveillance and disordered eating.

Technical activity profile and influence of body anthropometry on playing performance in female elite team handball.

PubMed

Michalsik, Lars B; Aagaard, Per; Madsen, Klavs

2015-04-01

To determine the physical demands placed on female elite team handball (TH) players in relation to playing position and body anthropometry, female elite TH primarily field players were monitored during match-play using video recording and subsequent computerized technical match analysis during 5 regular tournament match seasons. Technical match activities were distributed in 6 major types of playing actions (shots, breakthroughs, fast breaks, technical errors, defensive errors, and tackles) and further divided into various subcategories (e.g., type of shot, hard or light tackles, claspings, screenings, and blockings). Furthermore, anthropometric measurements were performed. Each player had 28.3 ± 11.0 (group means ± SD) high-intense playing actions per match with a total effective playing time of 50.70 ± 5.83 minutes. On average, each player made 2.8 ± 2.6 fast breaks, gave 7.9 ± 14.4 screenings, received 14.6 ± 9.2 tackles in total, and performed 7.7 ± 3.7 shots while in offense, along with 3.5 ± 3.8 blockings, 1.9 ± 2.7 claspings, and 6.2 ± 3.8 hard tackles in defense. Mean body height, body mass, and age in the Danish Premier Female Team Handball League were 175.4 ± 6.1 cm, 69.5 ± 6.5 kg, and 25.4 ± 3.7 years, respectively. Wing players were lighter (63.5 ± 4.8 kg, p < 0.001) and smaller (169.3 ± 4.9 cm, p < 0.001) than backcourt players (BP) (70.6 ± 5.3 kg, 177.0 ± 5.4 cm) and pivots (PV) (72.5 ± 4.9 kg, 177.7 ± 4.9 cm). In conclusion, the present match observations revealed that female elite TH players during competitive games intermittently perform a high number of short-term, high-intense technical playing actions making modern female elite TH a physically demanding team sport. No sign of technical fatigue were observed, since the amount of intense technical playing actions remained unchanged in the second half. Marked positional differences in the physical demands were demonstrated, with wing players performing more fast breaks and less physical confrontations than BP and PV. Body anthropometry differed substantially between different playing positions. Consequently, this should lead to an increase in physical training in modern female elite TH directed at specific positions and individual physical capacity.

Combining Next Generation Sequencing with Bulked Segregant Analysis to Fine Map a Stem Moisture Locus in Sorghum (Sorghum bicolor L. Moench).

PubMed

Han, Yucui; Lv, Peng; Hou, Shenglin; Li, Suying; Ji, Guisu; Ma, Xue; Du, Ruiheng; Liu, Guoqing

2015-01-01

Sorghum is one of the most promising bioenergy crops. Stem juice yield, together with stem sugar concentration, determines sugar yield in sweet sorghum. Bulked segregant analysis (BSA) is a gene mapping technique for identifying genomic regions containing genetic loci affecting a trait of interest that when combined with deep sequencing could effectively accelerate the gene mapping process. In this study, a dry stem sorghum landrace was characterized and the stem water controlling locus, qSW6, was fine mapped using QTL analysis and the combined BSA and deep sequencing technologies. Results showed that: (i) In sorghum variety Jiliang 2, stem water content was around 80% before flowering stage. It dropped to 75% during grain filling with little difference between different internodes. In landrace G21, stem water content keeps dropping after the flag leaf stage. The drop from 71% at flowering time progressed to 60% at grain filling time. Large differences exist between different internodes with the lowest (51%) at the 7th and 8th internodes at dough stage. (ii) A quantitative trait locus (QTL) controlling stem water content mapped on chromosome 6 between SSR markers Ch6-2 and gpsb069 explained about 34.7-56.9% of the phenotypic variation for the 5th to 10th internodes, respectively. (iii) BSA and deep sequencing analysis narrowed the associated region to 339 kb containing 38 putative genes. The results could help reveal molecular mechanisms underlying juice yield of sorghum and thus to improve total sugar yield.

A survey-based study on the protocols for therapeutic hypothermia in cardiac arrest patients in Korea: focusing on the differences between level 1 and 2 centers.

PubMed

Oh, Tae Gwan; Cha, Won Chul; Jo, Ik Joon; Kang, Mun Ju; Lee, Dong Woo

2015-12-01

We aimed to summarize the therapeutic hypothermia (TH) protocols used in emergency departments (EDs) in Korea and to investigate the differences between level 1 and 2 centers. The chief residents from 56 EDs were given a structured survey containing questions on the indications for TH, methods for TH induction, maintaining, and finalizing TH treatments. The participants were divided into 2 groups based on their work place (level 1 vs. level 2 centers). We received 36 responses to the survey. The majority of the participants (94.4%) reported that they routinely used TH. An average of 5.9 (standard deviation, 3.4) and 3.3 (standard deviation, 2.9) TH procedures were performed monthly in level 1 and 2 centers, respectively (P=0.01). The majority of level 1 and 2 centers (80.0% and 73.1%, respectively) had written TH protocols. Rectal (50.0%) and esophageal probes (38.9%) were most commonly used to monitor the patients' body temperatures. Midazolam (80.6%) and remifentanyl (47.2%) were the most commonly used sedatives. For TH induction, external cooling devices (77.8%) and cold saline infusion (66.1%) were predominant. Between level 1 and 2 centers, only the number of TH, the usage of remifentanyl, and application of external cooling device showed significant differences (P<0.05). Our study summarizes the TH protocols used in 36 EDs. The majority of study participants performed TH using a written protocol. We observed small number of differences in TH induction and maintenance methods between level 1 and 2 centers.

77 FR 57645 - Citizens Coinage Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-18

..., 2012. Time: 10 a.m. to 3 p.m. Location: Conference Room A, United States Mint, 801 9th Street NW... the CCAC; 801 9th Street NW., Washington, DC 20220; or call 202-354-7200. Any member of the public...

77 FR 12371 - Notification of Citizens Coinage Advisory Committee February 28, 2012, Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

...: Conference Room A, United States Mint, 801 9th Street NW., Washington, DC 20220. Subject: Review and... CONTACT: Andy Fishburn, United States Mint Liaison to the CCAC; 801 9th Street NW., Washington, DC 20220...

76 FR 73019 - Citizens Coinage Advisory Committee November 29, 2011; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-28

...: Conference Room A, United States Mint, 801 9th Street NW., Washington, DC 20220. Subject: Review and... the CCAC; 801 9th Street NW., Washington, DC 20220; or call (202) 354-6700. Any member of the public...

The ninth international veterinary immunology symposium

USDA-ARS?s Scientific Manuscript database

This Introduction to the special issue of Veterinary Immunology and Immunopathology summarizes the Proceedings of the 9th International Veterinary Immunology Symposium (9th IVIS) held August, 2010, in Tokyo, Japan. Over 340 delegates from 30 countries discussed research progress analyzing the immune...

Odessa Observatory as a Cultural and Scientific Educational Center on the Black Sea

NASA Astrophysics Data System (ADS)

Karetnikov, V. G.; Dorokhova, T. N.

2007-10-01

Odessa is a large port city on the Black Sea. Historically, transport, economy and business problems call forth the necessity of a major astronomical center in the city. In 2006 the Astronomical Observatory of Odessa National University celebrates its 135th Anniversary. Some interesting astronomical buildings and instruments of the 19th and 20th centuries, and the extensive scientific investigations which are reflected in numerous publications make the Observatory not only a scientific and educational establishment but also an historical and cultural center.

Radiological indeterminate vestibular schwannoma and meningioma in cerebellopontine angle area: differentiating using whole-tumor histogram analysis of apparent diffusion coefficient.

PubMed

Xu, Xiao-Quan; Li, Yan; Hong, Xun-Ning; Wu, Fei-Yun; Shi, Hai-Bin

2017-02-01

To assess the role of whole-tumor histogram analysis of apparent diffusion coefficient (ADC) maps in differentiating radiological indeterminate vestibular schwannoma (VS) from meningioma in cerebellopontine angle (CPA). Diffusion-weighted (DW) images (b = 0 and 1000 s/mm 2 ) of pathologically confirmed and radiological indeterminate CPA meningioma (CPAM) (n = 27) and VS (n = 12) were retrospectively collected and processed with mono-exponential model. Whole-tumor regions of interest were drawn on all slices of the ADC maps to obtain histogram parameters, including the mean ADC (ADC mean ), median ADC (ADC median ), 10th/25th/75th/90th percentile ADC (ADC 10 , ADC 25 , ADC 75 and ADC 90 ), skewness and kurtosis. The differences of ADC histogram parameters between CPAM and VS were compared using unpaired t-test. Multiple receiver operating characteristic (ROC) curves analysis was used to determine and compare the diagnostic value of each significant parameter. Significant differences were found on the ADC mean , ADC median , ADC 10 , ADC 25 , ADC 75 and ADC 90 between CPAM and VS (all p values < 0.001), while no significant difference was found on kurtosis (p = 0.562) and skewness (p = 0.047). ROC curves analysis revealed, a cut-off value of 1.126 × 10 -3 mm 2 /s for the ADC 90 value generated highest area under curves (AUC) for differentiating CPAM from VS (AUC, 0.975; sensitivity, 100%; specificity, 88.9%). Histogram analysis of ADC maps based on whole tumor can be a useful tool for differentiating radiological indeterminate CPAM from VS. The ADC 90 value was the most promising parameter for differentiating these two entities.

Crime and madness at the opposite shores of the Adriatic: moral insanity in Italian and Croatian psychiatric discourses.

PubMed

D'Alessio, Vanni; Čeč, Filip; Karge, Heike

2017-12-01

In the 19th century, fervid debates arose in the young psychiatric science about how to deal with and to scientifically categorize human behaviour which was perceived as dangerous to society, and as criminal. There were two concepts that stood out in these transnationally held discussions; namely moral insanity and later on, psychopathy. Following recent approaches in the cultural and social history of psychiatry, we understand moral insanity and psychopathy as social constructs, which are determined by the evolution in psychiatric knowledge, and also by laws, codes and social norms of particular historical timeframes. Our task is to discuss the evolution and adoption of these concepts in two linguistically different, but still historically profoundly entangled regions, namely in Italian and Croatian psychiatric discourses at the turn from the 19th to the 20th century. Our analysis of two of the most important medical and psychiatric journals of the time shows that psychiatric debates on antisocial and criminal behaviour were in numerous ways entangled and shaped by the way the two societies scientifically, legally, and institutionally struggled over the question of how to detect and control the mentally incapacitated criminal offender.

Harmonics rejection in pixelated interferograms using spatio-temporal demodulation.

PubMed

Padilla, J M; Servin, M; Estrada, J C

2011-09-26

Pixelated phase-mask interferograms have become an industry standard in spatial phase-shifting interferometry. These pixelated interferograms allow full wavefront encoding using a single interferogram. This allows the study of fast dynamic events in hostile mechanical environments. Recently an error-free demodulation method for ideal pixelated interferograms was proposed. However, non-ideal conditions in interferometry may arise due to non-linear response of the CCD camera, multiple light paths in the interferometer, etc. These conditions generate non-sinusoidal fringes containing harmonics which degrade the phase estimation. Here we show that two-dimensional Fourier demodulation of pixelated interferograms rejects most harmonics except the complex ones at {-3(rd), +5(th), -7(th), +9(th), -11(th),…}. We propose temporal phase-shifting to remove these remaining harmonics. In particular, a 2-step phase-shifting algorithm is used to eliminate the -3(rd) and +5(th) complex harmonics, while a 3-step one is used to remove the -3(rd), +5<(th), -7(th) and +9(th) complex harmonics. © 2011 Optical Society of America

MILD OBESITY IS PROTECTIVE AFTER SEVERE BURN INJURY

PubMed Central

Jeschke, Marc G.; Finnerty, Celeste C.; Emdad, Fatemeh; Rivero, Haidy G.; Kraft, Robert; Williams, Felicia N; Gamelli, Richard L.; Gibran, Nicole S.; Klein, Matthew B.; Arnoldo, Brett D.; Tompkins, Ronald G.; Herndon, David N.

2014-01-01

Objective To assess the impact of obesity on morbidity and mortality in severely burned patients. Background Despite the increasing number of people with obesity, little is known about the impact of obesity on postburn outcomes. Methods A total of 405 patients were prospectively enrolled as part of the multicenter trial Inflammation and the Host Response to Injury Glue Grant with the following inclusion criteria: 0 to 89 years of age, admitted within 96 hours after injury, and more than 20% total body surface area burn requiring at least 1 surgical intervention. Body mass index was used in adult patients to stratify according to World Health Organization definitions: less than 18.5 (underweight), 18.5 to 29.9 (normal weight), 30 to 34.9 (obese I), 35 to 39.9 (obese II), and body mass index more than 40 (obese III). Pediatric patients (2 to ≤18 years of age) were stratified by using the Centers for Disease Control and Prevention and World Health Organization body mass index-for-age growth charts to obtain a percentile ranking and then grouped as underweight (<5th percentile), normal weight (5th percentile to <95th percentile), and obese (≥95th percentile). The primary outcome was mortality and secondary outcomes were clinical markers of patient recovery, for example, multiorgan function, infections, sepsis, and length of stay. Results A total of 273 patients had normal weight, 116 were obese, and 16 were underweight; underweight patients were excluded from the analyses because of insufficient patient numbers. There were no differences in primary and secondary outcomes when normal weight patients were compared with obese patients. Further stratification in pediatric and adult patients showed similar results. However, when adult patients were stratified in obesity categories, log-rank analysis showed improved survival in the obese I group and higher mortality in the obese III group compared with obese I group (P < 0.05). Conclusions Overall, obesity was not associated with increased morbidity and mortality. Subgroup analysis revealed that patients with mild obesity have the best survival, whereas morbidly obese patients have the highest mortality. PMID:23877367

Military Presence: U.S. Personnel in NATO Europe.

DTIC Science & Technology

1989-10-06

Transportation 42nd Military 18th Engineer 26th Support Command Police Brigade Group Page.s GAO (.)SIA)-94)4 Militao I’ri-eeii in NATO Eurobpe Chapter 2...575 4th Transportation Command 3 585 0 3,585 7th Army Training Command 1 942 4 772 6,714 Other 0 9 551 9,551 Total 199,398 88,408 287,806 %ote Totals...p)ersolinel in Eiurope to siiI)l)01t Air Logistica SupportFor-ce op~erat ions. ’Ihel thr-ee largest commnands-the Air For-ce Commow- nications

Review of the 9th NLTE code comparison workshop

DOE PAGES

Piron, Robin; Gilleron, Franck; Aglitskiy, Yefim; ...

2017-02-24

Here, we review the 9th NLTE code comparison workshop, which was held in the Jussieu campus, Paris, from November 30th to December 4th, 2015. This time, the workshop was mainly focused on a systematic investigation of iron NLTE steady-state kinetics and emissivity, over a broad range of temperature and density. Through these comparisons, topics such as modeling of the dielectronic processes, density effects or the effect of an external radiation field were addressed. The K-shell spectroscopy of iron plasmas was also addressed, notably through the interpretation of tokamak and laser experimental spectra.

Review of the 9th NLTE code comparison workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piron, Robin; Gilleron, Franck; Aglitskiy, Yefim

Here, we review the 9th NLTE code comparison workshop, which was held in the Jussieu campus, Paris, from November 30th to December 4th, 2015. This time, the workshop was mainly focused on a systematic investigation of iron NLTE steady-state kinetics and emissivity, over a broad range of temperature and density. Through these comparisons, topics such as modeling of the dielectronic processes, density effects or the effect of an external radiation field were addressed. The K-shell spectroscopy of iron plasmas was also addressed, notably through the interpretation of tokamak and laser experimental spectra.

Review of the 9th NLTE code comparison workshop

NASA Astrophysics Data System (ADS)

Piron, R.; Gilleron, F.; Aglitskiy, Y.; Chung, H.-K.; Fontes, C. J.; Hansen, S. B.; Marchuk, O.; Scott, H. A.; Stambulchik, E.; Ralchenko, Yu.

2017-06-01

We review the 9th NLTE code comparison workshop, which was held in the Jussieu campus, Paris, from November 30th to December 4th, 2015. This time, the workshop was mainly focused on a systematic investigation of iron NLTE steady-state kinetics and emissivity, over a broad range of temperature and density. Through these comparisons, topics such as modeling of the dielectronic processes, density effects or the effect of an external radiation field were addressed. The K-shell spectroscopy of iron plasmas was also addressed, notably through the interpretation of tokamak and laser experimental spectra.

Pooled nucleic acid testing increases the diagnostic yield of acute HIV infections in a high-risk population compared to 3rd and 4th generation HIV enzyme immunoassays.

PubMed

Krajden, Mel; Cook, Darrel; Mak, Annie; Chu, Ken; Chahil, Navdeep; Steinberg, Malcolm; Rekart, Michael; Gilbert, Mark

2014-09-01

We compared a 3rd generation (gen) and two 4th gen HIV enzyme immunoassays (EIA) to pooled nucleic acid testing (PNAT) for the identification of pre- and early seroconversion acute HIV infection (AHI). 9550 specimens from males >18 year from clinics attended by men who have sex with men were tested by Siemens ADVIA Centaur(®) HIV 1/O/2 (3rd gen) and HIV Combo (4th gen), as well as by Abbott ARCHITECT(®) HIV Ag/Ab Combo (4th gen). Third gen non-reactive specimens were also tested by Roche COBAS(®) Ampliprep/COBAS® TaqMan HIV-1 Test v.2 in pools of 24 samples. Sensitivity and specificity of the three EIAs for AHI detection were compared. 7348 persons contributed 9435 specimens and had no evidence of HIV infection, 79 (94 specimens) had established HIV infection, 6 (9 specimens) had pre-seroconversion AHI and 9 (12 specimens) had early seroconversion AHI. Pre-seroconversion AHI cases were not detected by 3rd gen EIA, whereas 2/6 (33.3%) were detected by Siemens 4th gen, 4/6 (66.7%) by Abbott 4th gen and 6/6 (100%) by PNAT. All three EIAs and PNAT detected all individuals with early seroconversion AHI. Overall sensitivity/specificity for the EIAs relative to WB or NAT resolved infection status was 93.6%/99.9% for Siemens 3rd gen, 95.7%/99.7% for Siemens 4th gen and 97.9%/99.2% for Abbott 4th gen. While both 4th gen EIAs demonstrated improved sensitivity for AHI compared to 3rd gen EIA, PNAT identified more AHI cases than either 4th gen assay. PNAT is likely to remain a useful strategy to identify AHI in high-risk populations. Copyright © 2014 Elsevier B.V. All rights reserved.

Real-Time Dosimetry and Optimization of Prostate Photodynamic Therapy

DTIC Science & Technology

2006-09-01

photodynamic therapy in patients with prostate cancer,” IPA 9th World Congress of Photodynamic Medicine, (2003). 2. Zhu TC, Diana S, Dimofte A...photodynamic therapy,” IPA 9th World Congress of Photodynamic Medicine, (2003). 3. Zhu TC, Altschuler M, Xiao Y, Finlay J, Dimofte A, Hahn SM, “Light...Optimization of treatment plan using Cimmino algorithm in prostate photodynamic therapy,” IPA 10th World Congress of Photodynamic Medicine, Munich

Invertebrate Fossils: Clues to the Distant Past. [Aids to Individualize the Teaching of Science, Mini-Course Units for Grades 7, 8, and 9.

ERIC Educational Resources Information Center

Geist, John E.

This booklet, one of a series developed by the Frederick County Board of Education, Frederick, Maryland, provides an instruction module for an individualized or flexible approach to 7th, 8th, and 9th grade science teaching. Subjects and activities in this series of booklets are designed to supplement a basic curriculum or to form a total…

Proceedings of the 1976 Army Numerical and Computer Analysis Conference Held at US Army Research Office, Research Triangle Park, North Carolina, 11-12 February 1976

DTIC Science & Technology

1976-09-01

3 PI TERMS LTV * FlrRCF,**f 1 + R)*LENfiTH**f2*A l TIrlF**17*i? - C) s smn flF EXPH~QSInN soL ~lT!nN FOR Pf TFRn FORCFn l * . innnnnanL 01 AREA... Sol vc tho governing equations implicitly, the same sp:tcr:-staggcrcd schcmc is used. The implicit code employs an alternating-direction tcchniquc...Hansen, W. "Hydrodynamical Methods Applied to Oceano - graphic Problems", Proceedings of the Symposium on Mathematical-Hydrodynamical Methods of

Numerical simulation of temperature field in K9 glass irradiated by ultraviolet pulse laser

NASA Astrophysics Data System (ADS)

Wang, Xi; Fang, Xiaodong

2015-10-01

The optical component of photoelectric system was easy to be damaged by irradiation of high power pulse laser, so the effect of high power pulse laser irradiation on K9 glass was researched. A thermodynamic model of K9 glass irradiated by ultraviolet pulse laser was established using the finite element software ANSYS. The article analyzed some key problems in simulation process of ultraviolet pulse laser damage of K9 glass based on ANSYS from the finite element models foundation, meshing, loading of pulse laser, setting initial conditions and boundary conditions and setting the thermal physical parameters of material. The finite element method (FEM) model was established and a numerical analysis was performed to calculate temperature field in K9 glass irradiated by ultraviolet pulse laser. The simulation results showed that the temperature of irradiation area exceeded the melting point of K9 glass, while the incident laser energy was low. The thermal damage dominated in the damage mechanism of K9 glass, the melting phenomenon should be much more distinct.

75 FR 32372 - Western Pacific Fishery Management Council; Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... 104th Scientific and Statistical Committee (SSC) and 148th Council meetings to take recommendations and... complete scheduled business. Schedule and Agenda for 104th SSC Meeting: Tuesday, June 22, 2010, 8:30 a.m. 1... a.m. 9. Other Business A. 105th SSC Meeting 10. Summary of SSC Recommendations to the Council 148th...

Department of Defense Cost Analysis Symposium (26th) on Cost Analysis in an Uncertain Defense Environment Held in Washington, DC on 9-11 September 1992

DTIC Science & Technology

1992-09-09

ASHER Office of the Assistant Secretary of Defense (Program, Analysis & Evaluation) MR. JAMES C. PILGER Office of the Assistant Secretary of the Army...CHANGES TO THE MAJOR WEAPONS SYSTEM ACQUISITION PROCESS The major weapon system acquisition processes forged during the Cold War may not be practical...No one can estimate the extent of cost growth with a high degree of accuracy. However, review of 30-40 years of cold war history dops allow the

Methods for Analysis and Simulation of Ballistic Impact

DTIC Science & Technology

2017-04-01

ARL-RP-0597 ● Apr 2017 US Army Research Laboratory Methods for Analysis and Simulation of Ballistic Impact by John D Clayton...Laboratory Methods for Analysis and Simulation of Ballistic Impact by John D Clayton Weapons and Materials Research Directorate, ARL...analytical, and numerical methods of ballistics research . Similar lengthy references dealing with pertinent aspects include [8, 9]. In contrast, the

A recursive algorithm for Zernike polynomials

NASA Technical Reports Server (NTRS)

Davenport, J. W.

1982-01-01

The analysis of a function defined on a rotationally symmetric system, with either a circular or annular pupil is discussed. In order to numerically analyze such systems it is typical to expand the given function in terms of a class of orthogonal polynomials. Because of their particular properties, the Zernike polynomials are especially suited for numerical calculations. Developed is a recursive algorithm that can be used to generate the Zernike polynomials up to a given order. The algorithm is recursively defined over J where R(J,N) is the Zernike polynomial of degree N obtained by orthogonalizing the sequence R(J), R(J+2), ..., R(J+2N) over (epsilon, 1). The terms in the preceding row - the (J-1) row - up to the N+1 term is needed for generating the (J,N)th term. Thus, the algorith generates an upper left-triangular table. This algorithm was placed in the computer with the necessary support program also included.

96th LHCC meeting Agenda OPEN Session and CLOSED Session

ScienceCinema

Wyatt, Terry

2018-06-20

OPEN Session on Wednesday, 19 November 2008 at 9h00-11h00 in Main Auditorium, Live webcast. Followed by CLOSED Session , 6th floor Conference room and continued on Thursday, 20 November 2008 9h00-13h00.

75 FR 62184 - Notification of Citizens Coinage Advisory Committee October 26, 2010 Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... (Room A), United States Mint, 801 9th Street, NW., Washington, DC 20220. Subject: Review and discuss... the CCAC; 801 9th Street, NW., Washington, DC 20220; or call 202-354-7200. Any member of the public...

78 FR 68158 - Citizens Coinage Advisory Committee; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-13

... 22, 2013. Time: 10:00 a.m. to 4:30 p.m. Location: Conference Room A, United States Mint, 801 9th... the CCAC; 801 9th Street NW., Washington, DC 20220; or call 202-354-7200. Any member of the public...

75 FR 6791 - Notification of Citizens Coinage Advisory Committee February 2010 Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

..., United States Mint, 801 9th Street NW., Washington, DC 20220. Subject: Review 2011 First Spouse Gold Coin... the CCAC, 801 9th Street, NW., Washington, DC 20220; or call 202-354-7200. Any member of the public...

The 9th annual computational and systems neuroscience (cosyne) meeting

PubMed Central

2012-01-01

The 9th annual Computational and Systems Neuroscience meeting (Cosyne) was held 23–26 February in Salt Lake City, Utah. Cosyne meeting is the forum for exchange of experimental and theoretical/computational approaches to studying systems neuroscience. PMID:22464174

DWI-associated entire-tumor histogram analysis for the differentiation of low-grade prostate cancer from intermediate-high-grade prostate cancer.

PubMed

Wu, Chen-Jiang; Wang, Qing; Li, Hai; Wang, Xiao-Ning; Liu, Xi-Sheng; Shi, Hai-Bin; Zhang, Yu-Dong

2015-10-01

To investigate diagnostic efficiency of DWI using entire-tumor histogram analysis in differentiating the low-grade (LG) prostate cancer (PCa) from intermediate-high-grade (HG) PCa in comparison with conventional ROI-based measurement. DW images (b of 0-1400 s/mm(2)) from 126 pathology-confirmed PCa (diameter >0.5 cm) in 110 patients were retrospectively collected and processed by mono-exponential model. The measurement of tumor apparent diffusion coefficients (ADCs) was performed with using histogram-based and ROI-based approach, respectively. The diagnostic ability of ADCs from two methods for differentiating LG-PCa (Gleason score, GS ≤ 6) from HG-PCa (GS > 6) was determined by ROC regression, and compared by McNemar's test. There were 49 LG-tumor and 77 HG-tumor at pathologic findings. Histogram-based ADCs (mean, median, 10th and 90th) and ROI-based ADCs (mean) showed dominant relationships with ordinal GS of Pca (ρ = -0.225 to -0.406, p < 0.05). All above imaging indices reflected significant difference between LG-PCa and HG-PCa (all p values <0.01). Histogram 10th ADCs had dominantly high Az (0.738), Youden index (0.415), and positive likelihood ratio (LR+, 2.45) in stratifying tumor GS against mean, median and 90th ADCs, and ROI-based ADCs. Histogram mean, median, and 10th ADCs showed higher specificity (65.3%-74.1% vs. 44.9%, p < 0.01), but lower sensitivity (57.1%-71.3% vs. 84.4%, p < 0.05) than ROI-based ADCs in differentiating LG-PCa from HG-PCa. DWI-associated histogram analysis had higher specificity, Az, Youden index, and LR+ for differentiation of PCa Gleason grade than ROI-based approach.

Histogram Analysis of Diffusion Tensor Imaging Parameters in Pediatric Cerebellar Tumors.

PubMed

Wagner, Matthias W; Narayan, Anand K; Bosemani, Thangamadhan; Huisman, Thierry A G M; Poretti, Andrea

2016-05-01

Apparent diffusion coefficient (ADC) values have been shown to assist in differentiating cerebellar pilocytic astrocytomas and medulloblastomas. Previous studies have applied only ADC measurements and calculated the mean/median values. Here we investigated the value of diffusion tensor imaging (DTI) histogram characteristics of the entire tumor for differentiation of cerebellar pilocytic astrocytomas and medulloblastomas. Presurgical DTI data were analyzed with a region of interest (ROI) approach to include the entire tumor. For each tumor, histogram-derived metrics including the 25th percentile, 75th percentile, and skewness were calculated for fractional anisotropy (FA) and mean (MD), axial (AD), and radial (RD) diffusivity. The histogram metrics were used as primary predictors of interest in a logistic regression model. Statistical significance levels were set at p < .01. The study population included 17 children with pilocytic astrocytoma and 16 with medulloblastoma (mean age, 9.21 ± 5.18 years and 7.66 ± 4.97 years, respectively). Compared to children with medulloblastoma, children with pilocytic astrocytoma showed higher MD (P = .003 and P = .008), AD (P = .004 and P = .007), and RD (P = .003 and P = .009) values for the 25th and 75th percentile. In addition, histogram skewness showed statistically significant differences for MD between low- and high-grade tumors (P = .008). The 25th percentile for MD yields the best results for the presurgical differentiation between pediatric cerebellar pilocytic astrocytomas and medulloblastomas. The analysis of other DTI metrics does not provide additional diagnostic value. Our study confirms the diagnostic value of the quantitative histogram analysis of DTI data in pediatric neuro-oncology. Copyright © 2015 by the American Society of Neuroimaging.

A dynamical classification of the cosmic web

NASA Astrophysics Data System (ADS)

Forero-Romero, J. E.; Hoffman, Y.; Gottlöber, S.; Klypin, A.; Yepes, G.

2009-07-01

In this paper, we propose a new dynamical classification of the cosmic web. Each point in space is classified in one of four possible web types: voids, sheets, filaments and knots. The classification is based on the evaluation of the deformation tensor (i.e. the Hessian of the gravitational potential) on a grid. The classification is based on counting the number of eigenvalues above a certain threshold, λth, at each grid point, where the case of zero, one, two or three such eigenvalues corresponds to void, sheet, filament or a knot grid point. The collection of neighbouring grid points, friends of friends, of the same web type constitutes voids, sheets, filaments and knots as extended web objects. A simple dynamical consideration of the emergence of the web suggests that the threshold should not be null, as in previous implementations of the algorithm. A detailed dynamical analysis would have found different threshold values for the collapse of sheets, filaments and knots. Short of such an analysis a phenomenological approach has been opted for, looking for a single threshold to be determined by analysing numerical simulations. Our cosmic web classification has been applied and tested against a suite of large (dark matter only) cosmological N-body simulations. In particular, the dependence of the volume and mass filling fractions on λth and on the resolution has been calculated for the four web types. We also study the percolation properties of voids and filaments. Our main findings are as follows. (i) Already at λth = 0.1 the resulting web classification reproduces the visual impression of the cosmic web. (ii) Between 0.2 <~ λth <~ 0.4, a system of percolated voids coexists with a net of interconnected filaments. This suggests a reasonable choice for λth as the parameter that defines the cosmic web. (iii) The dynamical nature of the suggested classification provides a robust framework for incorporating environmental information into galaxy formation models, and in particular to semi-analytical models.

Mutagenic assessment of Lithobates catesbeianus tadpoles exposed to the 2,4-D herbicide in a simulated realistic scenario.

PubMed

Mesak, Carlos; de Oliveira Mendes, Bruna; de Oliveira Ferreira, Raíssa; Malafaia, Guilherme

2018-05-01

The aim of the current study is to assess possible erythrocyte mutagenic effects on Lithobates catesbeianus tadpoles exposed to water contaminated with 2,4-D. In order to do so, tadpoles were exposed to a predictive and environmentally relevant herbicide concentration (1.97 mg/L), which is likely to be found in lentic environments formed by superficial water runoffs in pasture areas where the herbicide was applied. The micronucleus test, as well as tests for other nuclear abnormalities, was conducted after 3, 5, and 9 days of exposure (d.e.). Changes in the biomass and mouth-cloaca length or interference in the larval development of the animals (in the three evaluated times) were not recorded. However, tadpoles exposed to 2,4-D showed the highest total number of nuclear abnormalities, as well as the highest frequency of binucleated erythrocytes and kidney-shaped nuclei (shortly after 3 d.e.). The micronucleus frequency was also higher in animals exposed to 2,4-D (in the 3rd, 5th, and 9th d.e.), as well as the frequency of binucleated cells (3rd, 5th, and 9th d.e.) presenting notched (9th d.e.) and blebbled (9th d.e.) nuclei in comparison to those of the control, after 5 and 9 days of exposure. Therefore, the current study is a pioneer in showing that 2,4-D has a mutagenic effect on L. catesbeianus tadpoles, even at low concentrations (environmentally relevant) and for a short period of time, a fact that may lead to direct losses in anuran populations living in areas adjacent to those subjected to 2,4-D herbicide application.

Numerical and Calculation Abilities in Children with ADHD

ERIC Educational Resources Information Center

Colomer, Carla; Re, Anna M.; Miranda, Ana; Lucangeli, Daniela

2013-01-01

The aim of this study was to investigate the specific numerical and calculation abilities of 28 children with ADHD without comorbid mathematical learning disabilities (LD), ranging from the 1st to the 5th grade of primary school, and to examine the stability or the development of the arithmetic profile. Our results showed that a high percentage of…

Proceedings of the U.S. Air Force and The Federal Republic of Germany Data Exchange Agreement Meeting (9th), Viscous and Interacting Flow Field Effects Held at Silver Spring, Maryland on 9-10 May 1984,

DTIC Science & Technology

1984-08-01

found in References 1-3. 2. Modeling of Roughness Effects on Turbulent Flow In turbulent flow analysis , use of time-averaged equations leads to the...eddy viscosity and the mixing length which are important parameters used in current algebraic modeling of the turbulence shear term. Two different ...surfaces with three-dimensional (distributed) roughness elements. Calculations using the present model have been compared with experimental data from

Reimbursements and frequency of tests in privately insured testicular cancer patients in the United States: Implications to national guidelines.

PubMed

Kamel, Mohamed H; Barber, Austin; Davis, Rodney; Raheem, Omer A; Bissada, Nabil; Abdelmaksoud, Alaa Eldin A; Eltahawy, Ehab

2017-01-01

The objective of this study was to assess the frequency of utilization and reimbursement of the common diagnostic tests and treatment modalities used in testicular cancer care. LifeLink™ (IMS Health, Danbury, CT, USA) Claims Database was used. We identified 877 subjects with a primary diagnosis of testicular cancer (ICD 186.9) between 2007 and 2012. Median reimbursement and frequency of the diagnostic/treatment modalities used were recorded. The most common claim was a vein puncture with median reimbursement of $9.11. Tumor markers, alpha-fetoprotein and beta human chorionic gonadotropin, were ranked 6 th and 7 th with median reimbursement of $52.13 and $48.71, respectively. Chest X-ray and computerized tomography (CT) scan of the chest were ranked 9 th and 13 th with median reimbursement of $68.51 and $769, respectively. A contrast CT scan of abdomen and pelvis was the 11 th most frequent claim with median reimbursement of $855.89. The three invasive treatment modalities, chemotherapy, radiation therapy, and retroperitoneal lymphadenectomy were ranked 8 th , 15 th , and 164 th with median reimbursement of $2858.38, $3988.25, and $2009.67, respectively. Testicular cancer is not an inexpensive disease. Surgery is the less utilized than radiation and chemotherapy despite lower cost. This may have implications to national guidelines and training since these treatments often carry the same grade of recommendation.

Induction of tyrosine hydroxylase mRNA by nicotine in rat midbrain is inhibited by mifepristone

PubMed Central

Radcliffe, Pheona M.; Sterling, Carol R.; Tank, A. William

2009-01-01

Repeated nicotine administration induces tyrosine hydroxylase (TH) mRNA in rat midbrain. In this study we investigate the mechanisms responsible for this response using two models of midbrain dopamine neurons, rat ventral midbrain slice explant cultures and mouse MN9D cells. In both models nicotine stimulates TH gene transcription rate in a dose-dependent manner. However, this stimulation is short-lived, lasting for 1 hr, but less than 3 hr, and is not sufficient to induce TH mRNA or TH protein. Nicotine elevates circulating glucocorticoids, which induce TH expression in some model systems. We tested the hypothesis that the effect of nicotine on midbrain TH mRNA is mediated by the glucocorticoid receptor. When rats are administered the glucocorticoid receptor antagonist mifepristone, the induction of TH mRNA by nicotine in both substantia nigra and ventral tegmentum is inhibited. Furthermore, the glucocorticoid receptor agonist dexamethasone stimulates TH gene transcription for sustained periods of time in both midbrain slices and MN9D cells, leading to induction of TH mRNA and TH protein. Our results are consistent with the hypothesis that nicotine induces TH mRNA in midbrain by elevating glucocorticoids, which then act on glucocorticoid receptors in dopamine neurons leading to transcriptional activation of the TH gene. PMID:19476543

Beyond the Standard Measures: Physical Education's Impact on the Dialogue about Obesity in the 20th Century

ERIC Educational Resources Information Center

Wrynn, Alison M.

2011-01-01

As numerous Homans' lecturers have attested, Amy Morris Homans was a significant and visionary leader who set the foundation for women's physical education for the first half of the 20th century. Her reign at the Boston Normal School for Gymnastics (BNSG) was ironclad, and through the BNSG she controlled her student's lives, including their…

Solar-simulator-pumped atomic iodine laser kinetics

NASA Technical Reports Server (NTRS)

Wilson, H. W.; Raju, S.; Shiu, Y. J.

1983-01-01

The literature contains broad ranges of disagreement in kinetic data for the atomic iodine laser. A kinetic model of a solar-simulator-pumped iodine laser is used to select those kinetic data consistent with recent laser experiments at the Langley Research Center. Analysis of the solar-simulator-pumped laser experiments resulted in the following estimates of rate coefficients: for alkyl radical (n-C3F7) and atomic iodine (I) recombination, 4.3 x 10 to the 11th power (1.9) + or - cu cm/s; for n-C3F7I stabilized atomic iodine recombination (I + I) 3.7 x 10 to the -32nd power (2.3) + or -1 cm to the 6th power/s; and for molecular iodine (I2) quenching, 3.1 x 10 to the -11th power (1.6) + or - 1 cu cm/s. These rates are consistent with the recent measurements.

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (78th, Washington, DC, August 9-12, 1995). Miscellaneous.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Miscellaneous section of the proceedings contains the following 15 papers: "Selling to the Sellers: An Analysis of Advertising in 'Campaigns & Elections,' 1980-1994" (Michael S. Sweeney); "From 'Seventeen' to 'Sassy': Teen Magazines and the Construction of the 'Model' Girl" (Lisa Duke); "Survey Data Indicate Some…

Periodic gamma-ray emissions from Geminga at or = 10(12) eV

NASA Technical Reports Server (NTRS)

Kaul, R. K.; Rawat, H. S.; Sanecha, V. K.; Rannot, R. C.; Sapru, M.; Tickoo, A. K.; Qazi, R. A.; Bhat, C. L.; Razdan, H.; Tonwar, S. C.

1985-01-01

Analysis of data from an atmospheric Cerenkov telescope indicated the periodic emission of gamma rays of energy 10 to the 12th power eV, at 60.25 second period, from 2CG 195+4. The gamma ray flux at 99% confidence level is estimated to be 9.5 x 10 to 12 photons/sq cm/s.

Analysis of High School Physics, Chemistry and Biology Curriculums in Terms of Scientific Literacy Themes

ERIC Educational Resources Information Center

Erdogan, Melek Nur; Koseoglu, Fitnat

2012-01-01

The purpose of this study is to analyze 9th grade physics, chemistry and biology curriculums, which were implemented by the Ministry of Education since the academic year 2008-2009, in terms of scientific literacy themes and the balance of these themes and also to examine the quality of statements about objectives. Physics, chemistry, and biology…

Calendar

NASA Astrophysics Data System (ADS)

2004-04-01

MAY 2004 GARP's 3rd Credit & Counterparty Risk Summit, London, UK 21-23 May 2004 Andreas Simou (andreas.simou@garp.com), +44 (0)20 7626 9301, www.garp.com/events/3rdcred IMA Workshop 9: Financial Data Analysis and Applications, University of Minnesota, MN, USA 24-28 May 2004 www.ima.umn.edu/complex/spring/c9.html Global Derivatives & Risk Management 2004, NH Eurobuilding, Madrid, Spain 25-28 May 2004 Aden Watkins, ICBI (awatkins@iirltd.co.uk), +44 (0)20 7915 5198, www.icbi-uk.com/globalderivatives/ WEHIA'04 9th Workshop on Economics and Heterogeneous Interacting Agents, Kyodai-Kaikan, Kyoto, Japan 27-29 May 2004 www.nda.ac.jp/cs/AI/wehia04/ JUNE 2004 Semimartingale Theory and Practice in Finance, Pacific Institute for the Mathematical Sciences, Vancouver, BC, Canada 5-10 June 2004 www.pims.math.ca/birs/workshops/2004/04w5032/ MC2QMC 2004 International Conference on Monte Carlo and Quasi-Monte Carlo Methods, Juan-les-Pins, Côte d'Azur, France 7-10 June 2004 Monique Simonetti (Monique.Simonetti@sophia.inria.fr), +33 4 92 38 78 64, www-sop.inria.fr/omega/MC2QMC2004/ GAIM'04 10th Annual Global Alternative Investment Management Forum, The Beaulieu Centre, Lausanne, Switzerland 8-11 June 2004 +44 (0)20 7915 5103, www.icbi-uk.com/gaim/ 3rd Annual Conference Ri$k Management 2004, Fairmont Hotel, Dubai, United Arab Emirates 12-15 June 2004 www.iirme.com/risk/ 10th Annual Risk USA Congress, Boston, MA, USA 21-24 June 2004 Aristotle Liu (aliu@riskwaters.com), +44 (0)207 484 9700, www.riskusa.com Mannheim Empirical Research Summer School, Mannheim University, Germany 22 June-2 July 2004 oliver@kirchkamp.de, www.sfb504.uni-mannheim.de/merss 9th Annual Conference on Econometric Modelling for Africa, Cape Town, South Africa 30 June-2 July 2004 aesinfo@commerce.uct.ac.za, www.commerce.uct.ac.za/economics/AES2004Conference/ 4th Congress of Nonlinear Analysts. Special Session on Mathematical Methods in Theoretical Finance, Hyatt Grand Cypress Resort, Orlando, FL, USA 30 June-7 July 2004 dkermani@fit.edu, +1 321 674 7412, http://kermani.math.fit.edu/ JULY 2004 2nd World Congress of the Game Theory Society, Faculty of Luminy, Marseille, France 5-9 July 2004 Europa Organisation (europa@europa-organisation.com), +33 5 34 45 26 45, www.gts2004.org Budapest Workshop on Behavioral Economics, Central European University, Budapest, Hungary 5-10 July 2004 Eva Dotzi (behavecon@ceu.hu), www.iza.org/en/calls_conferences/CallCEU_04.pdf FDA'04 1st IFAC Workshop on Fractional Differentiation and its Applications, Bordeaux, France 19-20 July 2004 IFAC secretariat (fda04@lap.u-bordeaux1.fr), www.lap.u-bordeaux.fr/fda04/ Bachelier Finance Society Third World Congress, InterContinental Hotel, Chicago, IL, USA 21-24 July 2004 bfs2004@uic.edu, www.uic.edu/orgs/bachelier/ BS/IMS 2004 6th World Congress of the Bernoulli Society for Mathematical Statistics and Probability, Barcelona, Spain 26-31 July 2004 wc2004@pacifico-meetings.com, +34 93 402 13 85, www.imub.ub.es/events/wc2004 AUGUST 2004 Summer School in Econometrics. The Cointegrated VAR Model: Econometric Methodology and Macroeconomic Applications, Institute of Economics, University of Copenhagen, Denmark 2-22 August 2004 Summerschool@econ.ku.dk, www.econ.ku.dk/summerschool SEPTEMBER 2004 First Bonzenfreies Colloquium on Market Dynamics and Quantitative Economics, Alessandria, Palazzo Borsalino, Italy 9-10 September 2004 colloquium@unipmn.it, www.mfn.unipmn.it/~colloqui/ Risk Analysis 2004. 4th International Conference on Computer Simulation in Risk Analysis and Hazard Mitigation, Aldemar Paradise Royal Mare Hotel, Rhodes, Greece 27-29 September 2004 enquiries@wessex.ac.uk, +44 (0)238 029 3223, www.wessex.ac.uk/conferences/2004/risk04/ OCTOBER 2004 IRC Hedge 2004, InterContinental Hotel, London, UK 10, 11 October 2004 enquiries@irc-conferences.com, www.irc-conferences.com/show_conference.php?id=10 NOVEMBER 2004 IRC DICE 2004, InterContinental Hotel, London, UK 22, 23 November 2004 enquiries@irc-conferences.com, www.irc-conferences.com/show_conference.php?id=13 DECEMBER 2004 Quantitative Methods in Finance 2004, Sydney, Australia 15-18 December 2004 Andrea Schnaufer (qmf@uts.edu.au), +61 2 9514 7737, www.business.uts.edu.au/finance/resources/qmf2004/

Changes in skin tanning attitudes. Fashion articles and advertisements in the early 20th century.

PubMed

Martin, Jo M; Ghaferi, Jessica M; Cummins, Deborah L; Mamelak, Adam J; Schmults, Chrys D; Parikh, Mona; Speyer, Lark-Aeryn; Chuang, Alice; Richardson, Hazel V; Stein, David; Liégeois, Nanette J

2009-12-01

Historical reviews suggest that tanning first became fashionable in the 1920s or 1930s. To quantitatively and qualitatively examine changes in tanning attitudes portrayed in the popular women's press during the early 20th century, we reviewed summer issues of Vogue and Harper's Bazaar for the years 1920, 1927, 1928, and 1929. We examined these issues for articles and advertisements promoting skin tanning or skin bleaching and protection. We found that articles and advertisements promoting the fashionable aspects of tanned skin were more numerous in 1928 and 1929 than in 1927 and 1920, whereas those promoting pale skin (by bleaching or protection) were less numerous. These findings demonstrate a clear shift in attitudes toward tanned skin during this period.

SCO X-1: Origin of the radio and hard X-ray emissions

NASA Technical Reports Server (NTRS)

Ramaty, R.; Cheng, C. C.; Tsuruta, S.

1973-01-01

The consequences of models for the central radio source and the hard X-ray ( 30 keV) emitting region in Sco X-1 are examined. It was found that the radio emission could result from noncoherent synchrotron radiation and that the X-rays may be produced by bremsstrahlung. It is shown that both mechanisms require a mass outflow from Sco X-1. The radio source is located at r approximately 3x10 to the 12th power cm from the center of the star, and its linear dimensions do not exceed 3x10 to the 13th power cm. The magnetic field in the radio source is on the order of 1 gauss. If the hard X-rays are produced by thermal bremsstrahlung, their source is located at 10 to the 9th power approximately r approximately 5x10 to the 9th power cm, the temperature is 2x10 to the 9th power K, and the emission measure is 2x10 to the 56th power/cu cm. This hot plasma loses energy inward by conduction and outward by supersonic expansion. The rates of energy loss for both processes are about 10 to the 36th power erg/s, comparable to the total luminosity of Sco X-1.

Alternative plasticizer, 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester, for blood containers with protective effects on red blood cells and improved cold resistance.

PubMed

Morishita, Yuki; Nomura, Yusuke; Fukui, Chie; Fujisawa, Ayano; Watanabe, Kayo; Fujimaki, Hideo; Kumada, Hidefumi; Inoue, Kaoru; Morikawa, Tomomi; Takahashi, Miwa; Kawakami, Tsuyoshi; Sakoda, Hideyuki; Mukai, Tomokazu; Yuba, Toshiyasu; Inamura, Ken-Ichi; Tanoue, Akito; Miyazaki, Ken-Ichi; Chung, Ung-Il; Ogawa, Kumiko; Yoshida, Midori; Haishima, Yuji

2018-04-01

Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC), is eluted from PVC-made blood containers and protects against red blood cell (RBC) hemolysis. However, concerns have arisen regarding the reproductive and developmental risks of DEHP in humans, and the use of alternative plasticizers for medical devices has been recommended worldwide. In this study, we propose that the use of a novel plasticizer, 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester (DL9TH), could help produce more useful and safe blood containers. PVC sheet containing DL9TH and di (2-ethylhexyl) 4-cyclohexene-1,2-dicarboxylate (DOTH) provides comparable or superior protective effects to RBCs relative to PVC sheet containing DEHP or di-isononyl-cyclohexane-1,2-dicarboxylate (DINCH ® , an alternative plasticizer that has been used in PVC sheets for blood containers). The total amount of plasticizer eluted from DOTH/DL9TH-PVC sheets is nearly the same as that eluted from DEHP-PVC sheets. In addition, DOTH/DL9TH-PVC has better cold resistance than DEHP- and DINCH ® -PVC sheets. In vitro and in vivo tests for biological safety based on International Organization for Standardization guidelines (10993 series) suggest that the DOTH/DL9TH-PVC sheet can be used safely. Subchronic toxicity testing of DL9TH in male rats in accordance with the principles of Organisation for Economic Co-operation and Development Test Guideline 408 showed that DL9TH did not induce adverse effects up to the highest dose level tested (717 mg/kg body weight/day). There were no effects on testicular histopathology and sperm counts, and no indications of endocrine effects: testosterone, thyroid-stimulating hormone, follicle-stimulating hormone, and 17β-estradiol were unchanged by the treatment, compared with the control group. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1052-1063, 2018. © 2017 Wiley Periodicals, Inc.

Earthlinks '97: Proceedings of the Biennial National Conference of the Australian Association for Environmental Education and the Marine Education Society of Australasia (9th, Hobart, Tasmania, Australia, January 13-17, 1997).

ERIC Educational Resources Information Center

Todd, John J., Ed.

This document contains the proceedings of the 9th Biennial National Conference of the Australian Association for Environmental Education and the Marine Society of Australasia. The contents provide a valuable snapshot of the state of environmental education in Australia while moving towards the end of the 20th century. Papers include: (1)…

Locating and Searching Electronic Documents: A User Study of Supply Publications in the United States Marine Corps

DTIC Science & Technology

2007-12-01

Boyle, “Important issues in hypertext documentation usability,” In Proceedings of the 9th Annual international Conference on Systems Documentation...Tufte’s principles of information design to creating effective Web sites.” In Proceedings of the 15th Annual international Conference on Computer...usability,” In Proceedings of the 9th Annual international Conference on Systems Documentation (Chicago, Illinois, 1991). SIGDOC 󈨟. ACM, New York, NY

Trapped Electron Model 2 (TEM-2)

DTIC Science & Technology

2010-04-25

density and computes sample correlations : 9t = ft-{ft)T, («6) £T = (stsf)T, («7) RT = {9t9j+i)r- (88) We have made the very safe...such as solar wind correlation studies, initial and boundary conditions for numerical simulations, and principal component analysis. We...O’Brien 19b. TELEPHONE NUMBER (include area code ) 571-307-3978 Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. 239.18 Ackmowledgments This work

A user's guide to the Mariner 9 television reduced data record

NASA Technical Reports Server (NTRS)

Seidman, J. B.; Green, W. B.; Jepsen, P. L.; Ruiz, R. M.; Thorpe, T. E.

1973-01-01

The Mariner 9 television experiment used two cameras to photograph Mars from an orbiting spacecraft. For quantitative analysis of the image data transmitted to earth, the pictures were processed by digital computer to remove camera-induced distortions. The removal process was performed by the JPL Image Processing Laboratory (IPL) using calibration data measured during prelaunch testing of the cameras. The Reduced Data Record (RDR) is the set of data which results from the distortion-removal, or decalibration, process. The principal elements of the RDR are numerical data on magnetic tape and photographic data. Numerical data are the result of correcting for geometric and photometric distortions and residual-image effects. Photographic data are reproduced on negative and positive transparency films, strip contact and enlargement prints, and microfiche positive transparency film. The photographic data consist of two versions of each TV frame created by applying two special enhancement processes to the numerical data.

Proceedings of the NASTRAN (Tradename) Users’ Colloquium (14th) Held in San Diego, California on 5-9 May 1986

DTIC Science & Technology

1986-05-01

4. Bossi, J. A., Price, G. A., and Winkleblack, S. A., " Flexible Spacecraft Controller Design Using the Integrated Analysis Capability (IAC)," AIAA...P., "Integrated Control System Design Capabilities at the Goddard Space Flight Center," Pro- ceedings of the 2nd IEEE Control Systems Society...Symposium on Computer- Aided Control System Design (CACSD), Santa Barbara, California, March, 13-15 1985. 6. Frisch, H. P. "Integrated Analysis Capability

Trajectories of Familism Values and the Prosocial Tendencies of Mexican American Adolescents

ERIC Educational Resources Information Center

Knight, George P.; Mazza, Gina L.; Carlo, Gustavo

2018-01-01

We examined how the development of familism values from 5th to 10th grade relates to 12th-grade prosocial tendencies (after controlling for 10th-grade prosocial tendencies) using a stratified random sample of 749 Mexican American adolescents (M = 10.42 years of age at 5th grade; 48.9% girls) from 35 culturally and economically diverse…