How to Overcome Numerical Challenges to Modeling Stirling Engines

NASA Technical Reports Server (NTRS)

Dyson, Rodger W.; Wilson, Scott D.; Tew, Roy C.

2004-01-01

Nuclear thermal to electric power conversion carries the promise of longer duration missions and higher scientific data transmission rates back to Earth for a range of missions, including both Mars rovers and deep space missions. A free-piston Stirling convertor is a candidate technology that is considered an efficient and reliable power conversion device for such purposes. While already very efficient, it is believed that better Stirling engines can be developed if the losses inherent in current designs could be better understood. However, they are difficult to instrument and so efforts are underway to simulate a complete Stirling engine numerically. This has only recently been attempted and a review of the methods leading up to and including such computational analysis is presented. And finally it is proposed that the quality and depth of Stirling loss understanding may be improved by utilizing the higher fidelity and efficiency of recently developed numerical methods. One such method, the Ultra HI-FI technique is presented in detail.

Annual Research Briefs - 2006

DTIC Science & Technology

2006-12-01

IACCARINO AND Q. WANG 3 Strain and stress analysis of uncertain engineering systems . D. GHOSH, C. FARHAT AND P. AVERY 17 Separated flow in a three...research in predictive science in complex systems , CTR has strived to maintain a critical mass in numerical analysis , computer science and physics based... analysis for a linear problem: heat conduction The design and analysis of complex engineering systems is challenging not only be- cause of the physical

Sensitivity of Emissions to Uncertainties in Residual Gas Fraction Measurements in Automotive Engines: A Numerical Study

DOE PAGES

Aithal, S. M.

2018-01-01

Initial conditions of the working fluid (air-fuel mixture) within an engine cylinder, namely, mixture composition and temperature, greatly affect the combustion characteristics and emissions of an engine. In particular, the percentage of residual gas fraction (RGF) in the engine cylinder can significantly alter the temperature and composition of the working fluid as compared with the air-fuel mixture inducted into the engine, thus affecting engine-out emissions. Accurate measurement of the RGF is cumbersome and expensive, thus making it hard to accurately characterize the initial mixture composition and temperature in any given engine cycle. This uncertainty can lead to challenges in accuratelymore » interpreting experimental emissions data and in implementing real-time control strategies. Quantifying the effects of the RGF can have important implications for the diagnostics and control of internal combustion engines. This paper reports on the use of a well-validated, two-zone quasi-dimensional model to compute the engine-out NO and CO emission in a gasoline engine. The effect of varying the RGF on the emissions under lean, near-stoichiometric, and rich engine conditions was investigated. Numerical results show that small uncertainties (~2–4%) in the measured/computed values of the RGF can significantly affect the engine-out NO/CO emissions.« less

Sensitivity of Emissions to Uncertainties in Residual Gas Fraction Measurements in Automotive Engines: A Numerical Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aithal, S. M.

Initial conditions of the working fluid (air-fuel mixture) within an engine cylinder, namely, mixture composition and temperature, greatly affect the combustion characteristics and emissions of an engine. In particular, the percentage of residual gas fraction (RGF) in the engine cylinder can significantly alter the temperature and composition of the working fluid as compared with the air-fuel mixture inducted into the engine, thus affecting engine-out emissions. Accurate measurement of the RGF is cumbersome and expensive, thus making it hard to accurately characterize the initial mixture composition and temperature in any given engine cycle. This uncertainty can lead to challenges in accuratelymore » interpreting experimental emissions data and in implementing real-time control strategies. Quantifying the effects of the RGF can have important implications for the diagnostics and control of internal combustion engines. This paper reports on the use of a well-validated, two-zone quasi-dimensional model to compute the engine-out NO and CO emission in a gasoline engine. The effect of varying the RGF on the emissions under lean, near-stoichiometric, and rich engine conditions was investigated. Numerical results show that small uncertainties (~2–4%) in the measured/computed values of the RGF can significantly affect the engine-out NO/CO emissions.« less

Evolutionarily Engineered Ethanologenic Yeast Detoxifies Lignocellulosic Biomass Conversion Inhibitors by Reprogrammed Pathways

USDA-ARS?s Scientific Manuscript database

Lignocellulosic biomass conversion inhibitors furfural and HMF inhibit microbial growth and interfere with subsequent fermentation of ethanol, posing significant challenges for a sustainable cellulosic ethanol conversion industry. Numerous yeast genes were found to be associated with the inhibitor ...

A Systems-Level Approach to Characterizing Effects of ENMs in Terrestrial Organisms and Ecosystems

EPA Science Inventory

Engineered nanomaterials (ENMs) represent a new regulatory challenge because of their unique properties and their potential to interact with ecological organisms at various developmental stages, in numerous environmental compartments. Traditional toxicity tests have proven to be...

Patient safety - the role of human factors and systems engineering.

PubMed

Carayon, Pascale; Wood, Kenneth E

2010-01-01

Patient safety is a global challenge that requires knowledge and skills in multiple areas, including human factors and systems engineering. In this chapter, numerous conceptual approaches and methods for analyzing, preventing and mitigating medical errors are described. Given the complexity of healthcare work systems and processes, we emphasize the need for increasing partnerships between the health sciences and human factors and systems engineering to improve patient safety. Those partnerships will be able to develop and implement the system redesigns that are necessary to improve healthcare work systems and processes for patient safety.

Skeletal Muscle Tissue Engineering: Methods to Form Skeletal Myotubes and Their Applications

PubMed Central

Ostrovidov, Serge; Hosseini, Vahid; Ahadian, Samad; Fujie, Toshinori; Parthiban, Selvakumar Prakash; Ramalingam, Murugan; Bae, Hojae; Kaji, Hirokazu

2014-01-01

Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate defective skeletal muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two decades after the introduction of SMTE, the engineering of functional skeletal muscle in the laboratory still remains a great challenge, and numerous techniques for growing functional muscle tissues are constantly being developed. This article reviews the recent findings regarding the methodology and various technical aspects of SMTE, including cell alignment and differentiation. We describe the structure and organization of muscle and discuss the methods for myoblast alignment cultured in vitro. To better understand muscle formation and to enhance the engineering of skeletal muscle, we also address the molecular basics of myogenesis and discuss different methods to induce myoblast differentiation into myotubes. We then provide an overview of different coculture systems involving skeletal muscle cells, and highlight major applications of engineered skeletal muscle tissues. Finally, potential challenges and future research directions for SMTE are outlined. PMID:24320971

Cognitive engineering and health informatics: Applications and intersections.

PubMed

Hettinger, A Zachary; Roth, Emilie M; Bisantz, Ann M

2017-03-01

Cognitive engineering is an applied field with roots in both cognitive science and engineering that has been used to support design of information displays, decision support, human-automation interaction, and training in numerous high risk domains ranging from nuclear power plant control to transportation and defense systems. Cognitive engineering provides a set of structured, analytic methods for data collection and analysis that intersect with and complement methods of Cognitive Informatics. These methods support discovery of aspects of the work that make performance challenging, as well as the knowledge, skills, and strategies that experts use to meet those challenges. Importantly, cognitive engineering methods provide novel representations that highlight the inherent complexities of the work domain and traceable links between the results of cognitive analyses and actionable design requirements. This article provides an overview of relevant cognitive engineering methods, and illustrates how they have been applied to the design of health information technology (HIT) systems. Additionally, although cognitive engineering methods have been applied in the design of user-centered informatics systems, methods drawn from informatics are not typically incorporated into a cognitive engineering analysis. This article presents a discussion regarding ways in which data-rich methods can inform cognitive engineering. Copyright © 2017 Elsevier Inc. All rights reserved.

EPA Water Resources Adaptation Program (WRAP) Research and Development Activities Methods and Techniques

EPA Science Inventory

Adaptation to environmental change is not a new concept. Humans have shown throughout history a capacity for adapting to different climates and environmental changes. Farmers, foresters, civil engineers, have all been forced to adapt to numerous challenges to overcome adversity...

Multimodal inspection in power engineering and building industries: new challenges and solutions

NASA Astrophysics Data System (ADS)

Kujawińska, Małgorzata; Malesa, Marcin; Malowany, Krzysztof

2013-09-01

Recently the demand and number of applications of full-field, optical measurement methods based on noncoherent light sources increased significantly. They include traditional image processing, thermovision, digital image correlation (DIC) and structured light methods. However, there are still numerous challenges connected with implementation of these methods to in-situ, long-term monitoring in industrial, civil engineering and cultural heritage applications, multimodal measurements of a variety of object features or simply adopting instruments to work in hard environmental conditions. In this paper we focus on 3D DIC method and present its enhancements concerning software modifications (new visualization methods and a method for automatic merging of data distributed in time) and hardware improvements. The modified 3D DIC system combined with infrared camera system is applied in many interesting cases: measurements of boiler drum during annealing and of pipelines in heat power stations and monitoring of different building steel struts at construction site and validation of numerical models of large building structures constructed of graded metal plate arches.

Breast tissue engineering.

PubMed

Patrick, Charles W

2004-01-01

Tissue engineering has the potential to redefine rehabilitation for the breast cancer patient by providing a translatable strategy that restores the postmastectomy breast mound while concomitantly obviating limitations realized with contemporary reconstructive surgery procedures. The engineering design goal is to provide a sufficient volume of viable fat tissue based on a patient's own cells such that deficits in breast volume can be abrogated. To be sure, adipose tissue engineering is in its infancy, but tremendous strides have been made. Numerous studies attest to the feasibility of adipose tissue engineering. The field is now poised to challenge barriers to clinical translation that are germane to most tissue engineering applications, namely scale-up, large animal model development, and vascularization. The innovative and rapid progress of adipose engineering to date, as well as opportunities for its future growth, is presented.

Robust Decision-making Applied to Model Selection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hemez, Francois M.

2012-08-06

The scientific and engineering communities are relying more and more on numerical models to simulate ever-increasingly complex phenomena. Selecting a model, from among a family of models that meets the simulation requirements, presents a challenge to modern-day analysts. To address this concern, a framework is adopted anchored in info-gap decision theory. The framework proposes to select models by examining the trade-offs between prediction accuracy and sensitivity to epistemic uncertainty. The framework is demonstrated on two structural engineering applications by asking the following question: Which model, of several numerical models, approximates the behavior of a structure when parameters that define eachmore » of those models are unknown? One observation is that models that are nominally more accurate are not necessarily more robust, and their accuracy can deteriorate greatly depending upon the assumptions made. It is posited that, as reliance on numerical models increases, establishing robustness will become as important as demonstrating accuracy.« less

Numerical simulation of turbulent combustion: Scientific challenges

NASA Astrophysics Data System (ADS)

Ren, ZhuYin; Lu, Zhen; Hou, LingYun; Lu, LiuYan

2014-08-01

Predictive simulation of engine combustion is key to understanding the underlying complicated physicochemical processes, improving engine performance, and reducing pollutant emissions. Critical issues as turbulence modeling, turbulence-chemistry interaction, and accommodation of detailed chemical kinetics in complex flows remain challenging and essential for high-fidelity combustion simulation. This paper reviews the current status of the state-of-the-art large eddy simulation (LES)/prob-ability density function (PDF)/detailed chemistry approach that can address the three challenging modelling issues. PDF as a subgrid model for LES is formulated and the hybrid mesh-particle method for LES/PDF simulations is described. Then the development need in micro-mixing models for the PDF simulations of turbulent premixed combustion is identified. Finally the different acceleration methods for detailed chemistry are reviewed and a combined strategy is proposed for further development.

Public Sector Agricultural Extension System Reform and the Challenges Ahead

ERIC Educational Resources Information Center

Rivera, William M.

2011-01-01

This paper is organized into two main sections. The first section examines extension as an engine for innovation and reviews the numerous priorities confronting extension systems. Section two highlights the current knowledge imperative and the critical connection of extension to post-secondary higher education and training, organizational…

Patient Safety: The Role of Human Factors and Systems Engineering

PubMed Central

Carayon, Pascale; Wood, Kenneth E.

2011-01-01

Patient safety is a global challenge that requires knowledge and skills in multiple areas, including human factors and systems engineering. In this chapter, numerous conceptual approaches and methods for analyzing, preventing and mitigating medical errors are described. Given the complexity of healthcare work systems and processes, we emphasize the need for increasing partnerships between the health sciences and human factors and systems engineering to improve patient safety. Those partnerships will be able to develop and implement the system redesigns that are necessary to improve healthcare work systems and processes for patient safety. PMID:20543237

Disruptive visions.

PubMed

Satava, R M

2002-10-01

Numerous advanced technologies, both medical and nonmedical, are emerging faster than their social, behavioral, political, moral, and ethical implications can be understood. Some of these technologies will fundamentally challenge the practice of surgery: human cloning, genetic engineering, tissue engineering, intelligent robotics, nanotechnology, suspended animation, regeneration, and species prolongation. Because of the rapidity of change, the current status of these emerging technologies with their specific moral and ethical issues must be addressed at this time by the new generation of surgeons, or we must all face the consequences of an uncontrolled and unprepared future.

Convert Ten Foot Environmental Test Chamber into an Ion Engine Test Chamber

NASA Technical Reports Server (NTRS)

VanVelzer, Paul

2006-01-01

The 10 Foot Space Simulator at the Jet Propulsion Laboratory has been used for the last 40 years to test numerous spacecraft, including the Ranger series, several Mariner class, among many others and finally, the Spirit and Opportunity Mars Rovers. The request was made to convert this facility to an Ion Engine test facility, with a possible long term life test. The Ion engine was to propel the Prometheus spacecraft to Jupiter's moons. This paper discusses the challenges that were met, both from a procedural and physical standpoint. The converted facility must operate unattended, support a 30 Kw Ion Engine, operate economically, and be easily converted back to former operation as a spacecraft test facility.

International Space Station Passive Thermal Control System Analysis, Top Ten Lessons-Learned

NASA Technical Reports Server (NTRS)

Iovine, John

2011-01-01

The International Space Station (ISS) has been on-orbit for over 10 years, and there have been numerous technical challenges along the way from design to assembly to on-orbit anomalies and repairs. The Passive Thermal Control System (PTCS) management team has been a key player in successfully dealing with these challenges. The PTCS team performs thermal analysis in support of design and verification, launch and assembly constraints, integration, sustaining engineering, failure response, and model validation. This analysis is a significant body of work and provides a unique opportunity to compile a wealth of real world engineering and analysis knowledge and the corresponding lessons-learned. The analysis lessons encompass the full life cycle of flight hardware from design to on-orbit performance and sustaining engineering. These lessons can provide significant insight for new projects and programs. Key areas to be presented include thermal model fidelity, verification methods, analysis uncertainty, and operations support.

A conservative fully implicit algorithm for predicting slug flows

NASA Astrophysics Data System (ADS)

Krasnopolsky, Boris I.; Lukyanov, Alexander A.

2018-02-01

An accurate and predictive modelling of slug flows is required by many industries (e.g., oil and gas, nuclear engineering, chemical engineering) to prevent undesired events potentially leading to serious environmental accidents. For example, the hydrodynamic and terrain-induced slugging leads to unwanted unsteady flow conditions. This demands the development of fast and robust numerical techniques for predicting slug flows. The presented in this paper study proposes a multi-fluid model and its implementation method accounting for phase appearance and disappearance. The numerical modelling of phase appearance and disappearance presents a complex numerical challenge for all multi-component and multi-fluid models. Numerical challenges arise from the singular systems of equations when some phases are absent and from the solution discontinuity when some phases appear or disappear. This paper provides a flexible and robust solution to these issues. A fully implicit formulation described in this work enables to efficiently solve governing fluid flow equations. The proposed numerical method provides a modelling capability of phase appearance and disappearance processes, which is based on switching procedure between various sets of governing equations. These sets of equations are constructed using information about the number of phases present in the computational domain. The proposed scheme does not require an explicit truncation of solutions leading to a conservative scheme for mass and linear momentum. A transient two-fluid model is used to verify and validate the proposed algorithm for conditions of hydrodynamic and terrain-induced slug flow regimes. The developed modelling capabilities allow to predict all the major features of the experimental data, and are in a good quantitative agreement with them.

Technology Integration in Science Classrooms: Framework, Principles, and Examples

ERIC Educational Resources Information Center

Kim, Minchi C.; Freemyer, Sarah

2011-01-01

A great number of technologies and tools have been developed to support science learning and teaching. However, science teachers and researchers point out numerous challenges to implementing such tools in science classrooms. For instance, guidelines, lesson plans, Web links, and tools teachers can easily find through Web-based search engines often…

Helping Students Succeed within Secondary-Level STEM Content: Using the "T" in STEM to Improve Literacy Skills

ERIC Educational Resources Information Center

Kennedy, Michael J.; Wexler, Jade

2013-01-01

Literacy and other content-specific demands presented within science, technology, engineering, and mathematics (STEM) coursework can overwhelm all students and especially students with learning challenges. Although STEM content is often complex in itself (e.g., numerous multisyllabic words, lengthy expository texts, abstract concepts), some…

van der Waals Layered Materials: Opportunities and Challenges.

PubMed

Duong, Dinh Loc; Yun, Seok Joon; Lee, Young Hee

2017-12-26

Since graphene became available by a scotch tape technique, a vast class of two-dimensional (2D) van der Waals (vdW) layered materials has been researched intensively. What is more intriguing is that the well-known physics and chemistry of three-dimensional (3D) bulk materials are often irrelevant, revealing exotic phenomena in 2D vdW materials. By further constructing heterostructures of these materials in the planar and vertical directions, which can be easily achieved via simple exfoliation techniques, numerous quantum mechanical devices have been demonstrated for fundamental research and technological applications. It is, therefore, necessary to review the special features in 2D vdW materials and to discuss the remaining issues and challenges. Here, we review the vdW materials library, technology relevance, and specialties of vdW materials covering the vdW interaction, strong Coulomb interaction, layer dependence, dielectric screening engineering, work function modulation, phase engineering, heterostructures, stability, growth issues, and the remaining challenges.

Numerical and Experimental Study of an Ambient Air Vaporizer Coupled with a Compact Heat Exchanger

NASA Astrophysics Data System (ADS)

Kimura, Randon

The University of Washington was tasked with designing a "21st century engine" that will make use of the thermal energy available in cryogenic gasses due to their coldness. There are currently large quantities of cryogenic gases stored throughout the U.S. at industrial facilities whereupon the regasification process, the potential for the fluid to do work is wasted. The engine proposed by the University of Washington will try to capture some of that wasted energy. One technical challenge that must be overcome during the regasification process is providing frost free operation. This thesis presents the numerical analysis and experimental testing of a passive heat exchange system that uses ambient vaporizers coupled with compact heat exchangers to provide frost free operation while minimizing pressure drop.

Recent Developments in Vascular Imaging Techniques in Tissue Engineering and Regenerative Medicine

PubMed Central

Upputuri, Paul Kumar; Sivasubramanian, Kathyayini; Mark, Chong Seow Khoon; Pramanik, Manojit

2015-01-01

Adequate vascularisation is key in determining the clinical outcome of stem cells and engineered tissue in regenerative medicine. Numerous imaging modalities have been developed and used for the visualization of vascularisation in tissue engineering. In this review, we briefly discuss the very recent advances aiming at high performance imaging of vasculature. We classify the vascular imaging modalities into three major groups: nonoptical methods (X-ray, magnetic resonance, ultrasound, and positron emission imaging), optical methods (optical coherence, fluorescence, multiphoton, and laser speckle imaging), and hybrid methods (photoacoustic imaging). We then summarize the strengths and challenges of these methods for preclinical and clinical applications. PMID:25821821

Numerical Schemes and Computational Studies for Dynamically Orthogonal Equations (Multidisciplinary Simulation, Estimation, and Assimilation Systems: Reports in Ocean Science and Engineering)

DTIC Science & Technology

2011-08-01

heat transfers [49, 52]. However, the DO method has not yet been applied to Boussinesq flows, and the numerical challenges of the DO decomposition for...used a PCE scheme to study mixing in a two-dimensional (2D) microchannel and improved the efficiency of their solution scheme by decoupling the...to several Navier-Stokes flows and their stochastic dynamics has been studied, including mean-mode and mode-mode energy transfers for 2D flows and

Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications

PubMed Central

Shi, Jinjun; Votruba, Alexander R.; Farokhzad, Omid C.; Langer, Robert

2010-01-01

The application of nanotechnology in medicine, referred to as nanomedicine, is offering numerous exciting possibilities in healthcare. Herein, we discuss two important aspects of nanomedicine—drug delivery and tissue engineering—highlighting the advances we have recently experienced, the challenges we are currently facing, and what we are likely to witness in the near future. PMID:20726522

Future Developments of Educational Research in the Asia-Pacific Region: Paradigm Shifts, Reforms, and Practice

ERIC Educational Resources Information Center

Cheng, Yin Cheong

2007-01-01

In facing up to the challenges and impacts of globalization, high technology, economic transformation, international competitions and local developments in the new century, there have been numerous educational reforms and initiatives in many countries in the Asia-Pacific Region (Cheng, 2005a, A new paradigm for re-engineering education:…

Rocksalt nitride metal/semiconductor superlattices: A new class of artificially structured materials

NASA Astrophysics Data System (ADS)

Saha, Bivas; Shakouri, Ali; Sands, Timothy D.

2018-06-01

Artificially structured materials in the form of superlattice heterostructures enable the search for exotic new physics and novel device functionalities, and serve as tools to push the fundamentals of scientific and engineering knowledge. Semiconductor heterostructures are the most celebrated and widely studied artificially structured materials, having led to the development of quantum well lasers, quantum cascade lasers, measurements of the fractional quantum Hall effect, and numerous other scientific concepts and practical device technologies. However, combining metals with semiconductors at the atomic scale to develop metal/semiconductor superlattices and heterostructures has remained a profoundly difficult scientific and engineering challenge. Though the potential applications of metal/semiconductor heterostructures could range from energy conversion to photonic computing to high-temperature electronics, materials challenges primarily had severely limited progress in this pursuit until very recently. In this article, we detail the progress that has taken place over the last decade to overcome the materials engineering challenges to grow high quality epitaxial, nominally single crystalline metal/semiconductor superlattices based on transition metal nitrides (TMN). The epitaxial rocksalt TiN/(Al,Sc)N metamaterials are the first pseudomorphic metal/semiconductor superlattices to the best of our knowledge, and their physical properties promise a new era in superlattice physics and device engineering.

Managing Legal Texts in Requirements Engineering

NASA Astrophysics Data System (ADS)

Otto, Paul N.; Antón, Annie I.

Laws and regulations are playing an increasingly important role in requirements engineering and systems development. Monitoring systems for requirements and policy compliance has been recognized in the requirements engineering community as a key area for research. Similarly, legal compliance is critical in systems development, especially given that non-compliance can result in both financial and criminal penalties. Working with legal texts can be very challenging, however, because they contain numerous ambiguities, cross-references, domain-specific definitions, and acronyms, and are frequently amended via new statutes, regulations, and case law. Requirements engineers and compliance auditors must be able to identify relevant legal texts, extract requirements and other key concepts, and monitor compliance. This chapter surveys research efforts over the past 50 years in handling legal texts for systems development. This survey can aid requirements engineers and auditors to better specify, test, and monitor systems for compliance.

A review of acoustic dampers applied to combustion chambers in aerospace industry

NASA Astrophysics Data System (ADS)

Zhao, Dan; Li, X. Y.

2015-04-01

In engine combustion systems such as rockets, aero-engines and gas turbines, pressure fluctuations are always present, even during normal operation. One of design prerequisites for the engine combustors is stable operation, since large-amplitude self-sustained pressure fluctuations (also known as combustion instability) have the potential to cause serious structural damage and catastrophic engine failure. To dampen pressure fluctuations and to reduce noise, acoustic dampers are widely applied as a passive control means to stabilize combustion/engine systems. However, they cannot respond to the dynamic changes of operating conditions and tend to be effective over certain narrow range of frequencies. To maintain their optimum damping performance over a broad frequency range, extensive researches have been conducted during the past four decades. The present work is to summarize the status, challenges and progress of implementing such acoustic dampers on engine systems. The damping effect and mechanism of various acoustic dampers, such as Helmholtz resonators, perforated liners, baffles, half- and quarter-wave tube are introduced first. A summary of numerical, experimental and theoretical studies are then presented to review the progress made so far. Finally, as an alternative means, ';tunable acoustic dampers' are discussed. Potential, challenges and issues associated with the dampers practical implementation are highlighted.

Therapeutic Genome Editing and its Potential Enhancement through CRISPR Guide RNA and Cas9 Modifications.

PubMed

Batzir, Nurit Assia; Tovin, Adi; Hendel, Ayal

2017-06-01

Genome editing with engineered nucleases is a rapidly growing field thanks to transformative technologies that allow researchers to precisely alter genomes for numerous applications including basic research, biotechnology, and human gene therapy. The genome editing process relies on creating a site-specific DNA double-strand break (DSB) by engineered nucleases and then allowing the cell's repair machinery to repair the break such that precise changes are made to the DNA sequence. The recent development of CRISPR-Cas systems as easily accessible and programmable tools for genome editing accelerates the progress towards using genome editing as a new approach to human therapeutics. Here we review how genome editing using engineered nucleases works and how using different genome editing outcomes can be used as a tool set for treating human diseases. We then review the major challenges of therapeutic genome editing and we discuss how its potential enhancement through CRISPR guide RNA and Cas9 protein modifications could resolve some of these challenges. Copyright© of YS Medical Media ltd.

Scheduling Mission-Critical Flows in Congested and Contested Airborne Network Environments

DTIC Science & Technology

2018-03-01

precision agriculture [64–71]. However, designing, implementing, and testing UAV networks poses numerous interdisciplinary challenges because the...applications including search and rescue, disaster relief, precision agriculture , environmental monitoring, and surveillance. Many of these applications...monitoring enabling precision agriculture ,” in Automation Science and Engineering (CASE), 2015 IEEE International Conference on. IEEE, 2015, pp. 462–469. [65

From Numerical Problem Solving to Model-Based Experimentation Incorporating Computer-Based Tools of Various Scales into the ChE Curriculum

ERIC Educational Resources Information Center

Shacham, Mordechai; Cutlip, Michael B.; Brauner, Neima

2009-01-01

A continuing challenge to the undergraduate chemical engineering curriculum is the time-effective incorporation and use of computer-based tools throughout the educational program. Computing skills in academia and industry require some proficiency in programming and effective use of software packages for solving 1) single-model, single-algorithm…

Dynamics of cracks in disordered materials

NASA Astrophysics Data System (ADS)

Bonamy, Daniel

2017-05-01

Predicting when rupture occurs or cracks progress is a major challenge in numerous fields of industrial, societal, and geophysical importance. It remains largely unsolved: stress enhancement at cracks and defects, indeed, makes the macroscale dynamics extremely sensitive to the microscale material disorder. This results in giant statistical fluctuations and non-trivial behaviors upon upscaling, difficult to assess via the continuum approaches of engineering.

Engineering Encounters: No, David! but Yes, Design! Kindergarten Students Are Introduced to a Design Way of Thinking

ERIC Educational Resources Information Center

Douglass, Helen

2016-01-01

This column presents ideas and techniques to enhance science teaching. In today's classrooms, teachers face numerous challenges. They are preparing students for jobs and careers that are not even conceived of yet. Assessments are being used to address students' college and career readiness and to promote critical thinking and problem solving.…

Space-Time Conservation Element and Solution Element Method Being Developed

NASA Technical Reports Server (NTRS)

Chang, Sin-Chung; Himansu, Ananda; Jorgenson, Philip C. E.; Loh, Ching-Yuen; Wang, Xiao-Yen; Yu, Sheng-Tao

1999-01-01

The engineering research and design requirements of today pose great computer-simulation challenges to engineers and scientists who are called on to analyze phenomena in continuum mechanics. The future will bring even more daunting challenges, when increasingly complex phenomena must be analyzed with increased accuracy. Traditionally used numerical simulation methods have evolved to their present state by repeated incremental extensions to broaden their scope. They are reaching the limits of their applicability and will need to be radically revised, at the very least, to meet future simulation challenges. At the NASA Lewis Research Center, researchers have been developing a new numerical framework for solving conservation laws in continuum mechanics, namely, the Space-Time Conservation Element and Solution Element Method, or the CE/SE method. This method has been built from fundamentals and is not a modification of any previously existing method. It has been designed with generality, simplicity, robustness, and accuracy as cornerstones. The CE/SE method has thus far been applied in the fields of computational fluid dynamics, computational aeroacoustics, and computational electromagnetics. Computer programs based on the CE/SE method have been developed for calculating flows in one, two, and three spatial dimensions. Results have been obtained for numerous problems and phenomena, including various shock-tube problems, ZND detonation waves, an implosion and explosion problem, shocks over a forward-facing step, a blast wave discharging from a nozzle, various acoustic waves, and shock/acoustic-wave interactions. The method can clearly resolve shock/acoustic-wave interactions, wherein the difference of the magnitude between the acoustic wave and shock could be up to six orders. In two-dimensional flows, the reflected shock is as crisp as the leading shock. CE/SE schemes are currently being used for advanced applications to jet and fan noise prediction and to chemically reacting flows.

SSME to RS-25: Challenges of Adapting a Heritage Engine to a New Vehicle Architecture

NASA Technical Reports Server (NTRS)

Ballard, Richard O.

2015-01-01

Following the cancellation of the Constellation program and retirement of the Space Shuttle, NASA initiated the Space Launch System (SLS) program to provide next-generation heavy lift cargo and crew access to space. A key constituent of the SLS architecture is the RS-25 engine, also known as the Space Shuttle Main Engine (SSME). The RS-25 was selected to serve as the main propulsion system for the SLS core stage in conjunction with the solid rocket boosters. This selection was largely based on the maturity and extensive experience gained through 135 missions, 3000+ ground tests, and over a million seconds total accumulated hot-fire time. In addition, there were also over a dozen functional flight assets remaining from the Space Shuttle program that could be leveraged to support the first four flights. However, while the RS-25 is a highly mature system, simply unbolting it from the Space Shuttle boat-tail and installing it on the new SLS vehicle is not a "plug-and-play" operation. In addition to numerous technical integration details involving changes to significant areas such as the environments, interface conditions, technical performance requirements, operational constraints and so on, there were other challenges to be overcome in the area of replacing the obsolete engine control system (ECS). While the magnitude of accomplishing this effort was less than that needed to develop and field a new clean-sheet engine system, the path to the first flight of SLS has not been without unexpected challenges.

A Review of Cellularization Strategies for Tissue Engineering of Whole Organs

PubMed Central

Scarritt, Michelle E.; Pashos, Nicholas C.; Bunnell, Bruce A.

2015-01-01

With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for organ engineering were generated from numerous tissues, including the heart, lung, liver, kidney, and pancreas, for use as alternatives to traditional organ transplantation. Biomedical researchers now face the challenge of adequately and efficiently recellularizing these organ scaffolds. Herein, an overview of whole organ decellularization and a thorough review of the current literature for whole organ recellularization are presented. The cell types, delivery methods, and bioreactors employed for recellularization are discussed along with commercial and clinical considerations, such as immunogenicity, biocompatibility, and Food and Drug Administartion regulation. PMID:25870857

Genomes by design

PubMed Central

Haimovich, Adrian D.; Muir, Paul; Isaacs, Farren J.

2016-01-01

Next-generation DNA sequencing has revealed the complete genome sequences of numerous organisms, establishing a fundamental and growing understanding of genetic variation and phenotypic diversity. Engineering at the gene, network and whole-genome scale aims to introduce targeted genetic changes both to explore emergent phenotypes and to introduce new functionalities. Expansion of these approaches into massively parallel platforms establishes the ability to generate targeted genome modifications, elucidating causal links between genotype and phenotype, as well as the ability to design and reprogramme organisms. In this Review, we explore techniques and applications in genome engineering, outlining key advances and defining challenges. PMID:26260262

A brief review on the recent advances in scramjet engine

NASA Astrophysics Data System (ADS)

Choubey, Gautam; Pandey, K. M.; Maji, Ambarish; Deshamukhya, Tuhin

2017-07-01

The scramjet engine is the most favourable air breathing propulsive system and suitable option for high-speed flight (Ma<4). Several scientists across the globe are continuously working on the advancement of the high-speed scramjet engine due to its implementation in the military missiles, low-cost access to space etc. The mixing phenomena associated with air and fuel is the salient feature for the effective combustion process and the fuel and air should be mixed adequately before entering into the combustor. But the key challenges associated with scramjet engine are the high speed of air inside the combustor and low residence time which actually deteriorate the combustion phenomena. That's why numerous computational, as well as experimental researches are being carried out by several researchers. The flow-field inside the scramjet engine is very complex. Hence an elaborated approach of the complicated combustion and mixing process inside the combustor is essential for the upgradation of the effective scramjet engine. This paper clearly signifies a brief review of the current development in scramjet engine.

Research approach to teaching groundwater biodegradation in karst aquifers

USGS Publications Warehouse

King, L.; Byl, T.; Painter, R.

2006-01-01

TSU in partnership with the USGS has conducted extensive research regarding biode??gradation of contaminants in karst aquifers. This research resulted in the development of a numerical approach to modeling biodegradation of contaminants in karst aquifers that is taught to environmental engineering students in several steps. First, environmental engineering students are taught chemical-reaction engineering principles relating to a wide variety of environmental fate and transport issues. Second, as part of TSU's engineering course curriculum, students use a non-ideal flow laboratory reactor system and run a tracer study to establish residence time distribution (RTD). Next, the students couple that formula to a first-order biodegradation rate and predict the removal of a biodegradable contaminant as a function of residence time. Following this, students are shown data collected from karst bedrock wells that suggest that karst aquifers are analogous to non-ideal flow reactors. The students are challenged to develop rates of biodegradation through lab studies and use their results to predict biodegradaton at an actual contaminated karst site. Field studies are also conducted to determine the accuracy of the students' predictions. This academic approach teaches biodegradation processes, rate-kinetic processes, hydraulic processes and numerical principles. The students are able to experience how chemical engineering principles can be applied to other situations, such as, modeling biodegradation of contaminants in karst aquifers. This paper provides background on the chemical engineering principles and karst issues used in the research-enhanced curriculum. ?? American Society for Engineering Education, 2006.

Spectral/ hp element methods: Recent developments, applications, and perspectives

NASA Astrophysics Data System (ADS)

Xu, Hui; Cantwell, Chris D.; Monteserin, Carlos; Eskilsson, Claes; Engsig-Karup, Allan P.; Sherwin, Spencer J.

2018-02-01

The spectral/ hp element method combines the geometric flexibility of the classical h-type finite element technique with the desirable numerical properties of spectral methods, employing high-degree piecewise polynomial basis functions on coarse finite element-type meshes. The spatial approximation is based upon orthogonal polynomials, such as Legendre or Chebychev polynomials, modified to accommodate a C 0 - continuous expansion. Computationally and theoretically, by increasing the polynomial order p, high-precision solutions and fast convergence can be obtained and, in particular, under certain regularity assumptions an exponential reduction in approximation error between numerical and exact solutions can be achieved. This method has now been applied in many simulation studies of both fundamental and practical engineering flows. This paper briefly describes the formulation of the spectral/ hp element method and provides an overview of its application to computational fluid dynamics. In particular, it focuses on the use of the spectral/ hp element method in transitional flows and ocean engineering. Finally, some of the major challenges to be overcome in order to use the spectral/ hp element method in more complex science and engineering applications are discussed.

Cell therapy, 3D culture systems and tissue engineering for cardiac regeneration.

PubMed

Emmert, Maximilian Y; Hitchcock, Robert W; Hoerstrup, Simon P

2014-04-01

Ischemic Heart Disease (IHD) still represents the "Number One Killer" worldwide accounting for the death of numerous patients. However the capacity for self-regeneration of the adult heart is very limited and the loss of cardiomyocytes in the infarcted heart leads to continuous adverse cardiac-remodeling which often leads to heart-failure (HF). The concept of regenerative medicine comprising cell-based therapies, bio-engineering technologies and hybrid solutions has been proposed as a promising next-generation approach to address IHD and HF. Numerous strategies are under investigation evaluating the potential of regenerative medicine on the failing myocardium including classical cell-therapy concepts, three-dimensional culture techniques and tissue-engineering approaches. While most of these regenerative strategies have shown great potential in experimental studies, the translation into a clinical setting has either been limited or too rapid leaving many key questions unanswered. This review summarizes the current state-of-the-art, important challenges and future research directions as to regenerative approaches addressing IHD and resulting HF. Copyright © 2014 Elsevier B.V. All rights reserved.

Model-based Acceleration Control of Turbofan Engines with a Hammerstein-Wiener Representation

NASA Astrophysics Data System (ADS)

Wang, Jiqiang; Ye, Zhifeng; Hu, Zhongzhi; Wu, Xin; Dimirovsky, Georgi; Yue, Hong

2017-05-01

Acceleration control of turbofan engines is conventionally designed through either schedule-based or acceleration-based approach. With the widespread acceptance of model-based design in aviation industry, it becomes necessary to investigate the issues associated with model-based design for acceleration control. In this paper, the challenges for implementing model-based acceleration control are explained; a novel Hammerstein-Wiener representation of engine models is introduced; based on the Hammerstein-Wiener model, a nonlinear generalized minimum variance type of optimal control law is derived; the feature of the proposed approach is that it does not require the inversion operation that usually upsets those nonlinear control techniques. The effectiveness of the proposed control design method is validated through a detailed numerical study.

Angiogenesis in tissue engineering: from concept to the vascularization of scaffold construct

NASA Astrophysics Data System (ADS)

Amirah Ishak, Siti; Pangestu Djuansjah, J. R.; Kadir, M. R. Abdul; Sukmana, Irza

2014-06-01

Angiogenesis, the formation of micro-vascular network from the preexisting vascular vessels, has been studied in the connection to the normal developmental process as well as numerous diseases. In tissue engineering research, angiogenesis is also essential to promote micro-vascular network inside engineered tissue constructs, mimicking a functional blood vessel in vivo. Micro-vascular network can be used to maintain adequate tissue oxygenation, nutrient transfer and waste removal. One of the problems faced by angiogenesis researchers is to find suitable in vitro assays and methods for assessing the effect of regulators on angiogenesis and micro-vessel formation. The assay would be reliable and repeatable with easily quantifiable with physiologically relevant. This review aims to highlights recent advanced and future challenges in developing and using an in vitro angiogenesis assay for the application on biomedical and tissue engineering research.

Distinguishing Nanobubbles from Nanodroplets with AFM: The Influence of Vertical and Lateral Imaging Forces.

PubMed

An, Hongjie; Tan, Beng Hau; Ohl, Claus-Dieter

2016-12-06

The widespread application of surface-attached nanobubbles and nanodroplets in biomedical engineering and nanotechnology is limited by numerous experimental challenges, in particular, the possibility of contamination in nucleation experiments. These challenges are complicated by recent reports that it can be difficult to distinguish between nanoscale drops and bubbles. Here we identify clear differences in the mechanical responses of nanobubbles and nanodroplets under various modes of AFM imaging that subject the objects to predominantly vertical or lateral forces. This allows us to distinguish among nanodroplets, nanobubbles, and oil-covered nanobubbles in water.

Modeling and Detection of Ice Particle Accretion in Aircraft Engine Compression Systems

NASA Technical Reports Server (NTRS)

May, Ryan D.; Simon, Donald L.; Guo, Ten-Huei

2012-01-01

The accretion of ice particles in the core of commercial aircraft engines has been an ongoing aviation safety challenge. While no accidents have resulted from this phenomenon to date, numerous engine power loss events ranging from uneventful recoveries to forced landings have been recorded. As a first step to enabling mitigation strategies during ice accretion, a detection scheme must be developed that is capable of being implemented on board modern engines. In this paper, a simple detection scheme is developed and tested using a realistic engine simulation with approximate ice accretion models based on data from a compressor design tool. These accretion models are implemented as modified Low Pressure Compressor maps and have the capability to shift engine performance based on a specified level of ice blockage. Based on results from this model, it is possible to detect the accretion of ice in the engine core by observing shifts in the typical sensed engine outputs. Results are presented in which, for a 0.1 percent false positive rate, a true positive detection rate of 98 percent is achieved.

Effort to Accelerate MBSE Adoption and Usage at JSC

NASA Technical Reports Server (NTRS)

Wang, Lui; Izygon, Michel; Okron, Shira; Garner, Larry; Wagner, Howard

2016-01-01

This paper describes the authors' experience in adopting Model Based System Engineering (MBSE) at the NASA/Johnson Space Center (JSC). Since 2009, NASA/JSC has been applying MBSE using the Systems Modeling Language (SysML) to a number of advanced projects. Models integrate views of the system from multiple perspectives, capturing the system design information for multiple stakeholders. This method has allowed engineers to better control changes, improve traceability from requirements to design and manage the numerous interactions between components. As the project progresses, the models become the official source of information and used by multiple stakeholders. Three major types of challenges that hamper the adoption of the MBSE technology are described. These challenges are addressed by a multipronged approach that includes educating the main stakeholders, implementing an organizational infrastructure that supports the adoption effort, defining a set of modeling guidelines to help engineers in their modeling effort, providing a toolset that support the generation of valuable products, and providing a library of reusable models. JSC project case studies are presented to illustrate how the proposed approach has been successfully applied.

Multiyear Program Plan for the High Temperature Materials Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arvid E. Pasto

2000-03-17

Recently, the U.S. Department of Energy's (DOE) Office of Heavy Vehicle Technologies (OHVT) prepared a Technology Roadmap describing the challenges facing development of higher fuel efficiency, less polluting sport utility vehicles, vans, and commercial trucks. Based on this roadmap, a multiyear program plan (MYPP) was also developed, in which approaches to solving the numerous challenges are enumerated. Additional planning has been performed by DOE and national laboratory staff, on approaches to solving the numerous challenges faced by heavy vehicle system improvements. Workshops and planning documents have been developed concerning advanced aerodynamics, frictional and other parasitic losses, and thermal management. Similarly,more » the Heavy Vehicle Propulsion Materials Program has developed its own multiyear program plan. The High Temperature Materials Laboratory, a major user facility sponsored by OHVT, has now developed its program plan, described herein. Information was gathered via participation in the development of OHVT's overall Technology Roadmap and MYPP, through personal contacts within the materials-user community, and from attendance at conferences and expositions. Major materials issues for the heavy vehicle industry currently center on trying to increase efficiency of (diesel) engines while at the same time reducing emissions (particularly NO{sub x} and particulates). These requirements dictate the use of increasingly stronger, higher-temperature capable and more corrosion-resistant materials of construction, as well as advanced catalysts, particulate traps, and other pollution-control devices. Exhaust gas recirculation (EGR) is a technique which will certainly be applied to diesel engines in the near future, and its use represents a formidable challenge, as will be described later. Energy-efficient, low cost materials processing methods and surface treatments to improve wear, fracture, and corrosion resistance are also required.« less

Modeling reacting gases and aftertreatment devices for internal combustion engines

NASA Astrophysics Data System (ADS)

Depcik, Christopher David

As more emphasis is placed worldwide on reducing greenhouse gas emissions, automobile manufacturers have to create more efficient engines. Simultaneously, legislative agencies want these engines to produce fewer problematic emissions such as nitrogen oxides and particulate matter. In response, newer combustion methods, like homogeneous charge compression ignition and fuel cells, are being researched alongside the old standard of efficiency, the compression ignition or diesel engine. These newer technologies present a number of benefits but still have significant challenges to overcome. As a result, renewed interest has risen in making diesel engines cleaner. The key to cleaning up the diesel engine is the placement of aftertreatment devices in the exhaust. These devices have shown great potential in reducing emission levels below regulatory levels while still allowing for increased fuel economy versus a gasoline engine. However, these devices are subject to many flow control issues. While experimental evaluation of these devices helps to understand these issues better, it is impossible to solve the problem through experimentation alone because of time and cost constraints. Because of this, accurate models are needed in conjunction with the experimental work. In this dissertation, the author examines the entire exhaust system including reacting gas dynamics and aftertreatment devices, and develops a complete numerical model for it. The author begins by analyzing the current one-dimensional gas-dynamics simulation models used for internal combustion engine simulations. It appears that more accurate and faster numerical method is available, in particular, those developed in aeronautical engineering, and the author successfully implements one for the exhaust system. The author then develops a comprehensive literature search to better understand the aftertreatment devices. A number of these devices require a secondary injection of fuel or reductant in the exhaust stream. Accordingly, the author develops a simple post-cylinder injection model which can be easily tuned to match experimental findings. In addition, the author creates a general catalyst model which can be used to model virtually all of the different aftertreatment devices. Extensive validation of this model with experimental data is presented along with all of the numerical algorithms needed to reproduce the model.

Wavelet-based identification of rotor blades in passage-through-resonance tests

NASA Astrophysics Data System (ADS)

Carassale, Luigi; Marrè-Brunenghi, Michela; Patrone, Stefano

2018-01-01

Turbine blades are critical components in turbo engines and their design process usually includes experimental tests in order to validate and/or update numerical models. These tests are generally carried out on full-scale rotors having some blades instrumented with strain gauges and usually involve a run-up or a run-down phase. The quantification of damping in these conditions is rather challenging for several reasons. In this work, we show through numerical simulations that the usual identification procedures lead to a systematic overestimation of damping due both to the finite sweep velocity, as well as to the variation of the blade natural frequencies with the rotation speed. To overcome these problems, an identification procedure based on the continuous wavelet transform is proposed and validated through numerical simulation.

Organically Grown Architectures: Creating Decentralized, Autonomous Systems by Embryomorphic Engineering

NASA Astrophysics Data System (ADS)

Doursat, René

Exploding growth growth in computational systems forces us to gradually replace rigid design and control with decentralization and autonomy. Information technologies will progress, instead, by"meta-designing" mechanisms of system self-assembly, self-regulation and evolution. Nature offers a great variety of efficient complex systems, in which numerous small elements form large-scale, adaptive patterns. The new engineering challenge is to recreate this self-organization and let it freely generate innovative designs under guidance. This article presents an original model of artificial system growth inspired by embryogenesis. A virtual organism is a lattice of cells that proliferate, migrate and self-pattern into differentiated domains. Each cell's fate is controlled by an internal gene regulatory network network. Embryomorphic engineering emphasizes hyperdistributed architectures, and their development as a prerequisite of evolutionary design.

A Scenario-Based Process for Requirements Development: Application to Mission Operations Systems

NASA Technical Reports Server (NTRS)

Bindschadler, Duane L.; Boyles, Carole A.

2008-01-01

The notion of using operational scenarios as part of requirements development during mission formulation (Phases A & B) is widely accepted as good system engineering practice. In the context of developing a Mission Operations System (MOS), there are numerous practical challenges to translating that notion into the cost-effective development of a useful set of requirements. These challenges can include such issues as a lack of Project-level focus on operations issues, insufficient or improper flowdown of requirements, flowdown of immature or poor-quality requirements from Project level, and MOS resource constraints (personnel expertise and/or dollars). System engineering theory must be translated into a practice that provides enough structure and standards to serve as guidance, but that retains sufficient flexibility to be tailored to the needs and constraints of a particular MOS or Project. We describe a detailed, scenario-based process for requirements development. Identifying a set of attributes for high quality requirements, we show how the portions of the process address many of those attributes. We also find that the basic process steps are robust, and can be effective even in challenging Project environments.

Optical projects in the Clinic program at Harvey Mudd College

NASA Astrophysics Data System (ADS)

Yang, Q.

2017-08-01

Clinic program is the senior capstone program at Harvey Mudd College (HMC). Multidisciplinary and industry-sponsored projects allow a team of students to solve a real-world problem over one academic year. Over its 50 plus years, Clinic program has completed numerous optics related projects. This report gives an overview of the Clinic program, reviews recent optical projects and discusses how this program supports the learning of the HMC engineering students. A few sample optical projects with more details are presented to provide an insight of what challenges that undergraduates can overcome. Students achieve learning within the optics discipline and the related engineering disciplines. The experiences in these optical projects indicate the great potential to bringing optical hands-on projects into the undergraduate level. Because of the general engineering curriculum at HMC, these projects often work the best with a multidisciplinary nature even if the core of the project is optically focused. Students gain leadership training, oral and written communication skills and experiences in team work. Close relationship with the sponsor liaisons allows for the students to gain skills in professional conduct, management of tight schedule and a specified budget, and it well prepares the students to their engineering practice. Optical projects have their own sets of specific challenges, so it needs to be chosen properly to match the undergraduate skill sets such as those of HMC engineering students.

Characterisation of two-stage ignition in diesel engine-relevant thermochemical conditions using direct numerical simulation

DOE PAGES

Krisman, Alex; Hawkes, Evatt R.; Talei, Mohsen; ...

2016-08-30

With the goal of providing a more detailed fundamental understanding of ignition processes in diesel engines, this study reports analysis of a direct numerical simulation (DNS) database. In the DNS, a pseudo turbulent mixing layer of dimethyl ether (DME) at 400 K and air at 900 K is simulated at a pressure of 40 atmospheres. At these conditions, DME exhibits a two-stage ignition and resides within the negative temperature coefficient (NTC) regime of ignition delay times, similar to diesel fuel. The analysis reveals a complex ignition process with several novel features. Autoignition occurs as a distributed, two-stage event. The high-temperaturemore » stage of ignition establishes edge flames that have a hybrid premixed/autoignition flame structure similar to that previously observed for lifted laminar flames at similar thermochemical conditions. In conclusion, a combustion mode analysis based on key radical species illustrates the multi-stage and multi-mode nature of the ignition process and highlights the substantial modelling challenge presented by diesel combustion.« less

Predicting catastrophes of non-autonomous networks with visibility graphs and horizontal visibility

NASA Astrophysics Data System (ADS)

Zhang, Haicheng; Xu, Daolin; Wu, Yousheng

2018-05-01

Prediction of potential catastrophes in engineering systems is a challenging problem. We first attempt to construct a complex network to predict catastrophes of a multi-modular floating system in advance of their occurrences. Response time series of the system can be mapped into an virtual network by using visibility graph or horizontal visibility algorithm. The topology characteristics of the networks can be used to forecast catastrophes of the system. Numerical results show that there is an obvious corresponding relationship between the variation of topology characteristics and the onset of catastrophes. A Catastrophe Index (CI) is proposed as a numerical indicator to measure a qualitative change from a stable state to a catastrophic state. The two approaches, the visibility graph and horizontal visibility algorithms, are compared by using the index in the reliability analysis with different data lengths and sampling frequencies. The technique of virtual network method is potentially extendable to catastrophe predictions of other engineering systems.

Physical Science Informatics: Providing Open Science Access to Microheater Array Boiling Experiment Data

NASA Technical Reports Server (NTRS)

McQuillen, John; Green, Robert D.; Henrie, Ben; Miller, Teresa; Chiaramonte, Fran

2014-01-01

The Physical Science Informatics (PSI) system is the next step in this an effort to make NASA sponsored flight data available to the scientific and engineering community, along with the general public. The experimental data, from six overall disciplines, Combustion Science, Fluid Physics, Complex Fluids, Fundamental Physics, and Materials Science, will present some unique challenges. Besides data in textual or numerical format, large portions of both the raw and analyzed data for many of these experiments are digital images and video, requiring large data storage requirements. In addition, the accessible data will include experiment design and engineering data (including applicable drawings), any analytical or numerical models, publications, reports, and patents, and any commercial products developed as a result of the research. This objective of paper includes the following: Present the preliminary layout (Figure 2) of MABE data within the PSI database. Obtain feedback on the layout. Present the procedure to obtain access to this database.

Project-based learning with international collaboration for training biomedical engineers.

PubMed

Krishnan, Shankar

2011-01-01

Training biomedical engineers while effectively keeping up with the fast paced scientific breakthroughs and the growth in technical innovations poses arduous challenges for educators. Traditional pedagogical methods are employed for coping with the increasing demands in biomedical engineering (BME) training and continuous improvements have been attempted with some success. Project-based learning (PBL) is an academic effort that challenges students by making them carry out interdisciplinary projects aimed at accomplishing a wide range of student learning outcomes. PBL has been shown to be effective in the medical field and has been adopted by other fields including engineering. The impact of globalization in healthcare appears to be steadily increasing which necessitates the inclusion of awareness of relevant international activities in the curriculum. Numerous difficulties are encountered when the formation of a collaborative team is tried, and additional difficulties occur as the collaboration team is extended to international partners. Understanding and agreement of responsibilities becomes somewhat complex and hence the collaborative project has to be planned and executed with clear understanding by all partners and participants. A model for training BME students by adopting PBL with international collaboration is proposed. The results of previous BME project work with international collaboration fit partially into the model. There were many logistic issues and constraints; however, the collaborative projects themselves greatly enhanced the student learning outcomes. This PBL type of learning experience tends to promote long term retention of multidisciplinary material and foster high-order cognitive activities such as analysis, synthesis and evaluation. In addition to introducing the students to experiences encountered in the real-life workforce, the proposed approach enhances developing professional contracts and global networking. In conclusion, despite initial challenges, adopting project-based learning with international collaboration has strong potentials to be valuable in the training of biomedical engineering students.

In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine.

PubMed

Chen, Feng; Hong, Hao; Goel, Shreya; Graves, Stephen A; Orbay, Hakan; Ehlerding, Emily B; Shi, Sixiang; Theuer, Charles P; Nickles, Robert J; Cai, Weibo

2015-01-01

Actively targeted theranostic nanomedicine may be the key for future personalized cancer management. Although numerous types of theranostic nanoparticles have been developed in the past decade for cancer treatment, challenges still exist in the engineering of biocompatible theranostic nanoparticles with highly specific in vivo tumor targeting capabilities. Here, we report the design, synthesis, surface engineering, and in vivo active vasculature targeting of a new category of theranostic nanoparticle for future cancer management. Water-soluble photothermally sensitive copper sulfide nanoparticles were encapsulated in biocompatible mesoporous silica shells, followed by multistep surface engineering to form the final theranostic nanoparticles. Systematic in vitro targeting, an in vivo long-term toxicity study, photothermal ablation evaluation, in vivo vasculature targeted imaging, biodistribution and histology studies were performed to fully explore the potential of as-developed new theranostic nanoparticles.

Simultaneous co-fermentation of mixed sugars: a promising strategy for producing cellulosic ethanol.

PubMed

Kim, Soo Rin; Ha, Suk-Jin; Wei, Na; Oh, Eun Joong; Jin, Yong-Su

2012-05-01

The lack of microbial strains capable of fermenting all sugars prevalent in plant cell wall hydrolyzates to ethanol is a major challenge. Although naturally existing or engineered microorganisms can ferment mixed sugars (glucose, xylose and galactose) in these hydrolyzates sequentially, the preferential utilization of glucose to non-glucose sugars often results in lower overall yield and productivity of ethanol. Therefore, numerous metabolic engineering approaches have been attempted to construct optimal microorganisms capable of co-fermenting mixed sugars simultaneously. Here, we present recent findings and breakthroughs in engineering yeast for improved ethanol production from mixed sugars. In particular, this review discusses new sugar transporters, various strategies for simultaneous co-fermentation of mixed sugars, and potential applications of co-fermentation for producing fuels and chemicals. Copyright © 2012 Elsevier Ltd. All rights reserved.

Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities

PubMed Central

Xia, An-Liang; Wang, Xiao-Chen; Lu, Yi-Jun; Lu, Xiao-Jie; Sun, Beicheng

2017-01-01

Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have been shown to have unprecedented efficacy in B cell malignancies, most notably in B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate using anti-CD19 CAR-T cells. However, CAR T-cell therapy for solid tumors currently is faced with numerous challenges such as physical barriers, the immunosuppressive tumor microenvironment and the specificity and safety. The clinical results in solid tumors have been much less encouraging, with multiple cases of toxicity and a lack of therapeutic response. In this review, we will discuss the current stats and challenges of CAR-T cell therapy for solid tumors, and propose possibl e solutions and future perspectives. PMID:29163850

Nanomaterials for Craniofacial and Dental Tissue Engineering.

PubMed

Li, G; Zhou, T; Lin, S; Shi, S; Lin, Y

2017-07-01

Tissue engineering shows great potential as a future treatment for the craniofacial and dental defects caused by trauma, tumor, and other diseases. Due to the biomimetic features and excellent physiochemical properties, nanomaterials are of vital importance in promoting cell growth and stimulating tissue regeneration in tissue engineering. For craniofacial and dental tissue engineering, the frequently used nanomaterials include nanoparticles, nanofibers, nanotubes, and nanosheets. Nanofibers are attractive for cell invasion and proliferation because of their resemblance to extracellular matrix and the presence of large pores, and they have been used as scaffolds in bone, cartilage, and tooth regeneration. Nanotubes and nanoparticles improve the mechanical and chemical properties of scaffold, increase cell attachment and migration, and facilitate tissue regeneration. In addition, nanofibers and nanoparticles are also used as a delivery system to carry the bioactive agent in bone and tooth regeneration, have better control of the release speed of agent upon degradation of the matrix, and promote tissue regeneration. Although applications of nanomaterials in tissue engineering remain in their infancy with numerous challenges to face, the current results indicate that nanomaterials have massive potential in craniofacial and dental tissue engineering.

Interactive Modelling of Salinity Intrusion in the Rhine-Meuse Delta

NASA Astrophysics Data System (ADS)

Baart, F.; Kranenburg, W.; Luijendijk, A.

2015-12-01

In many delta's of the world salinity intrusion imposes limits to fresh water availability. With increasing population and industry, the need for fresh water increases. But also salinity intrusion is expected to increase due to changes in river discharge, sea level and storm characteristics. In the Rhine-Meuse delta salt intrusion is impacted by human activities as well, like deepening of waterways and opening of delta-branches closed earlier. All these developments call for increasing the understanding of the system, but also for means for policy makers, coastal planners and engineers to assess effects of changes and to explore and design measures. In our presentation we present the developments in interactive modelling of salinity intrusion in the Rhine-Meuse delta. In traditional process-based numerical modelling, impacts are investigated by researchers and engineers by following the steps of pre-defining scenario's, running the model and post-processing the results. Interactive modelling lets users adjust simulations while running. Users can for instance change river discharges or bed levels, and can add measures like changes to geometry. The model will take the adjustments into account immediately, and will directly compute the effect. In this way, a tool becomes available with which coastal planners, policy makers and engineers together can develop and evaluate ideas and designs by interacting with the numerical model. When developing interactive numerical engines, one of the challenges is to optimize the exchange of variables as e.g. salt concentration. In our case we exchange variables on a 3D grid every time step. For this, the numerical model adheres to the Basic Model Interface (http://csdms.colorado.edu/wiki), which allows external control and the exchange of variables through pointers while the model is running. In our presentation we further explain our method and show examples of interactive design of salinity intrusion measures in the Rhine-Meuse delta.

The second Sandia Fracture Challenge. Predictions of ductile failure under quasi-static and moderate-rate dynamic loading

DOE PAGES

Boyce, B. L.; Kramer, S. L. B.; Bosiljevac, T. R.; ...

2016-03-14

Ductile failure of structural metals is relevant to a wide range of engineering scenarios. Computational methods are employed to anticipate the critical conditions of failure, yet they sometimes provide inaccurate and misleading predictions. Challenge scenarios, such as the one presented in the current work, provide an opportunity to assess the blind, quantitative predictive ability of simulation methods against a previously unseen failure problem. Instead of evaluating the predictions of a single simulation approach, the Sandia Fracture Challenge relied on numerous volunteer teams with expertise in computational mechanics to apply a broad range of computational methods, numerical algorithms, and constitutive modelsmore » to the challenge. This exercise is intended to evaluate the state of health of technologies available for failure prediction. In the first Sandia Fracture Challenge, a wide range of issues were raised in ductile failure modeling, including a lack of consistency in failure models, the importance of shear calibration data, and difficulties in quantifying the uncertainty of prediction [see Boyce et al. (Int J Fract 186:5–68, 2014) for details of these observations]. This second Sandia Fracture Challenge investigated the ductile rupture of a Ti–6Al–4V sheet under both quasi-static and modest-rate dynamic loading (failure in ~ 0.1 s). Like the previous challenge, the sheet had an unusual arrangement of notches and holes that added geometric complexity and fostered a competition between tensile- and shear-dominated failure modes. The teams were asked to predict the fracture path and quantitative far-field failure metrics such as the peak force and displacement to cause crack initiation. Fourteen teams contributed blind predictions, and the experimental outcomes were quantified in three independent test labs. In addition, shortcomings were revealed in this second challenge such as inconsistency in the application of appropriate boundary conditions, need for a thermomechanical treatment of the heat generation in the dynamic loading condition, and further difficulties in model calibration based on limited real-world engineering data. As with the prior challenge, this work not only documents the ‘state-of-the-art’ in computational failure prediction of ductile tearing scenarios, but also provides a detailed dataset for non-blind assessment of alternative methods.« less

The second Sandia Fracture Challenge. Predictions of ductile failure under quasi-static and moderate-rate dynamic loading

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyce, B. L.; Kramer, S. L. B.; Bosiljevac, T. R.

Ductile failure of structural metals is relevant to a wide range of engineering scenarios. Computational methods are employed to anticipate the critical conditions of failure, yet they sometimes provide inaccurate and misleading predictions. Challenge scenarios, such as the one presented in the current work, provide an opportunity to assess the blind, quantitative predictive ability of simulation methods against a previously unseen failure problem. Instead of evaluating the predictions of a single simulation approach, the Sandia Fracture Challenge relied on numerous volunteer teams with expertise in computational mechanics to apply a broad range of computational methods, numerical algorithms, and constitutive modelsmore » to the challenge. This exercise is intended to evaluate the state of health of technologies available for failure prediction. In the first Sandia Fracture Challenge, a wide range of issues were raised in ductile failure modeling, including a lack of consistency in failure models, the importance of shear calibration data, and difficulties in quantifying the uncertainty of prediction [see Boyce et al. (Int J Fract 186:5–68, 2014) for details of these observations]. This second Sandia Fracture Challenge investigated the ductile rupture of a Ti–6Al–4V sheet under both quasi-static and modest-rate dynamic loading (failure in ~ 0.1 s). Like the previous challenge, the sheet had an unusual arrangement of notches and holes that added geometric complexity and fostered a competition between tensile- and shear-dominated failure modes. The teams were asked to predict the fracture path and quantitative far-field failure metrics such as the peak force and displacement to cause crack initiation. Fourteen teams contributed blind predictions, and the experimental outcomes were quantified in three independent test labs. In addition, shortcomings were revealed in this second challenge such as inconsistency in the application of appropriate boundary conditions, need for a thermomechanical treatment of the heat generation in the dynamic loading condition, and further difficulties in model calibration based on limited real-world engineering data. As with the prior challenge, this work not only documents the ‘state-of-the-art’ in computational failure prediction of ductile tearing scenarios, but also provides a detailed dataset for non-blind assessment of alternative methods.« less

Looking forward to genetically edited fruit crops.

PubMed

Nagamangala Kanchiswamy, Chidananda; Sargent, Daniel James; Velasco, Riccardo; Maffei, Massimo E; Malnoy, Mickael

2015-02-01

The availability of genome sequences for many fruit crops has redefined the boundaries of genetic engineering and genetically modified (GM) crop plants. However commercialization of GM crops is hindered by numerous regulatory and social hurdles. Here, we focus on recently developed genome-editing tools for fruit crop improvement and their importance from the consumer perspective. Challenges and opportunities for the deployment of new genome-editing tools for fruit plants are also discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

Computing Generalized Matrix Inverse on Spiking Neural Substrate.

PubMed

Shukla, Rohit; Khoram, Soroosh; Jorgensen, Erik; Li, Jing; Lipasti, Mikko; Wright, Stephen

2018-01-01

Emerging neural hardware substrates, such as IBM's TrueNorth Neurosynaptic System, can provide an appealing platform for deploying numerical algorithms. For example, a recurrent Hopfield neural network can be used to find the Moore-Penrose generalized inverse of a matrix, thus enabling a broad class of linear optimizations to be solved efficiently, at low energy cost. However, deploying numerical algorithms on hardware platforms that severely limit the range and precision of representation for numeric quantities can be quite challenging. This paper discusses these challenges and proposes a rigorous mathematical framework for reasoning about range and precision on such substrates. The paper derives techniques for normalizing inputs and properly quantizing synaptic weights originating from arbitrary systems of linear equations, so that solvers for those systems can be implemented in a provably correct manner on hardware-constrained neural substrates. The analytical model is empirically validated on the IBM TrueNorth platform, and results show that the guarantees provided by the framework for range and precision hold under experimental conditions. Experiments with optical flow demonstrate the energy benefits of deploying a reduced-precision and energy-efficient generalized matrix inverse engine on the IBM TrueNorth platform, reflecting 10× to 100× improvement over FPGA and ARM core baselines.

Development and application of theoretical models for Rotating Detonation Engine flowfields

NASA Astrophysics Data System (ADS)

Fievisohn, Robert

As turbine and rocket engine technology matures, performance increases between successive generations of engine development are becoming smaller. One means of accomplishing significant gains in thermodynamic performance and power density is to use detonation-based heat release instead of deflagration. This work is focused on developing and applying theoretical models to aid in the design and understanding of Rotating Detonation Engines (RDEs). In an RDE, a detonation wave travels circumferentially along the bottom of an annular chamber where continuous injection of fresh reactants sustains the detonation wave. RDEs are currently being designed, tested, and studied as a viable option for developing a new generation of turbine and rocket engines that make use of detonation heat release. One of the main challenges in the development of RDEs is to understand the complex flowfield inside the annular chamber. While simplified models are desirable for obtaining timely performance estimates for design analysis, one-dimensional models may not be adequate as they do not provide flow structure information. In this work, a two-dimensional physics-based model is developed, which is capable of modeling the curved oblique shock wave, exit swirl, counter-flow, detonation inclination, and varying pressure along the inflow boundary. This is accomplished by using a combination of shock-expansion theory, Chapman-Jouguet detonation theory, the Method of Characteristics (MOC), and other compressible flow equations to create a shock-fitted numerical algorithm and generate an RDE flowfield. This novel approach provides a numerically efficient model that can provide performance estimates as well as details of the large-scale flow structures in seconds on a personal computer. Results from this model are validated against high-fidelity numerical simulations that may require a high-performance computing framework to provide similar performance estimates. This work provides a designer a new tool to conduct large-scale parametric studies to optimize a design space before conducting computationally-intensive, high-fidelity simulations that may be used to examine additional effects. The work presented in this thesis not only bridges the gap between simple one-dimensional models and high-fidelity full numerical simulations, but it also provides an effective tool for understanding and exploring RDE flow processes.

A Multidisciplinary Approach to Mixer-Ejector Analysis and Design

NASA Technical Reports Server (NTRS)

Hendricks, Eric, S.; Seidel, Jonathan, A.

2012-01-01

The design of an engine for a civil supersonic aircraft presents a difficult multidisciplinary problem to propulsion system engineers. There are numerous competing requirements for the engine, such as to be efficient during cruise while yet quiet enough at takeoff to meet airport noise regulations. The use of mixer-ejector nozzles presents one possible solution to this challenge. However, designing a mixer-ejector which will successfully address both of these concerns is a difficult proposition. Presented in this paper is an integrated multidisciplinary approach to the analysis and design of these systems. A process that uses several low-fidelity tools to evaluate both the performance and acoustics of mixer-ejectors nozzles is described. This process is further expanded to include system-level modeling of engines and aircraft to determine the effects on mission performance and noise near airports. The overall process is developed in the OpenMDAO framework currently being developed by NASA. From the developed process, sample results are given for a notional mixer-ejector design, thereby demonstrating the capabilities of the method.

Using Acellular Bioactive Extracellular Matrix Scaffolds to Enhance Endogenous Cardiac Repair

PubMed Central

Svystonyuk, Daniyil A.; Mewhort, Holly E. M.; Fedak, Paul W. M.

2018-01-01

An inability to recover lost cardiac muscle following acute ischemic injury remains the biggest shortcoming of current therapies to prevent heart failure. As compared to standard medical and surgical treatments, tissue engineering strategies offer the promise of improved heart function by inducing regeneration of functional heart muscle. Tissue engineering approaches that use stem cells and genetic manipulation have shown promise in preclinical studies but have also been challenged by numerous critical barriers preventing effective clinical translational. We believe that surgical intervention using acellular bioactive ECM scaffolds may yield similar therapeutic benefits with minimal translational hurdles. In this review, we outline the limitations of cellular-based tissue engineering strategies and the advantages of using acellular biomaterials with bioinductive properties. We highlight key anatomic targets enriched with cellular niches that can be uniquely activated using bioactive scaffold therapy. Finally, we review the evolving cardiovascular tissue engineering landscape and provide critical insights into the potential therapeutic benefits of acellular scaffold therapy. PMID:29696148

System Engineering for J-2X Development: The Simpler, the Better

NASA Technical Reports Server (NTRS)

Kelly, William M.; Greasley, Paul; Greene, William D.; Ackerman, Peter

2008-01-01

The Ares I and Ares V Vehicles will utilize the J-2X rocket engine developed for NASA by the Pratt and Whitney Rocketdyne Company (PWR) as the upper stage engine (USE). The J-2X is an improved higher power version of the original J-2 engine used for Apollo. System Engineering (SE) facilitates direct and open discussions of issues and problems. This simple idea is often overlooked in large, complex engineering development programs. Definition and distribution of requirements from the engine level to the component level is controlled by Allocation Reports which breaks down numerical design objectives (weight, reliability, etc.) into quanta goals for each component area. Linked databases of design and verification requirements help eliminate redundancy and potential mistakes inherent in separated systems. Another tool, the Architecture Design Description (ADD), is used to control J-2X system architecture and effectively communicate configuration changes to those involved in the design process. But the proof of an effective process is in successful program accomplishment. SE is the methodology being used to meet the challenge of completing J-2X engine certification 2 years ahead of any engine program ever developed at PWR. This paper describes the simple, better SE tools and techniques used to achieve this success.

Self-Scheduling Parallel Methods for Multiple Serial Codes with Application to WOPWOP

NASA Technical Reports Server (NTRS)

Long, Lyle N.; Brentner, Kenneth S.

2000-01-01

This paper presents a scheme for efficiently running a large number of serial jobs on parallel computers. Two examples are given of computer programs that run relatively quickly, but often they must be run numerous times to obtain all the results needed. It is very common in science and engineering to have codes that are not massive computing challenges in themselves, but due to the number of instances that must be run, they do become large-scale computing problems. The two examples given here represent common problems in aerospace engineering: aerodynamic panel methods and aeroacoustic integral methods. The first example simply solves many systems of linear equations. This is representative of an aerodynamic panel code where someone would like to solve for numerous angles of attack. The complete code for this first example is included in the appendix so that it can be readily used by others as a template. The second example is an aeroacoustics code (WOPWOP) that solves the Ffowcs Williams Hawkings equation to predict the far-field sound due to rotating blades. In this example, one quite often needs to compute the sound at numerous observer locations, hence parallelization is utilized to automate the noise computation for a large number of observers.

Development of Implantable Medical Devices: From an Engineering Perspective

PubMed Central

2013-01-01

From the first pacemaker implant in 1958, numerous engineering and medical activities for implantable medical device development have faced challenges in materials, battery power, functionality, electrical power consumption, size shrinkage, system delivery, and wireless communication. With explosive advances in scientific and engineering technology, many implantable medical devices such as the pacemaker, cochlear implant, and real-time blood pressure sensors have been developed and improved. This trend of progress in medical devices will continue because of the coming super-aged society, which will result in more consumers for the devices. The inner body is a special space filled with electrical, chemical, mechanical, and marine-salted reactions. Therefore, electrical connectivity and communication, corrosion, robustness, and hermeticity are key factors to be considered during the development stage. The main participants in the development stage are the user, the medical staff, and the engineer or technician. Thus, there are three different viewpoints in the development of implantable devices. In this review paper, considerations in the development of implantable medical devices will be presented from the viewpoint of an engineering mind. PMID:24143287

Changes and challenges in the Software Engineering Laboratory

NASA Technical Reports Server (NTRS)

Pajerski, Rose

1994-01-01

Since 1976, the Software Engineering Laboratory (SEL) has been dedicated to understanding and improving the way in which one NASA organization, the Flight Dynamics Division (FDD), develops, maintains, and manages complex flight dynamics systems. The SEL is composed of three member organizations: NASA/GSFC, the University of Maryland, and Computer Sciences Corporation. During the past 18 years, the SEL's overall goal has remained the same: to improve the FDD's software products and processes in a measured manner. This requires that each development and maintenance effort be viewed, in part, as a SEL experiment which examines a specific technology or builds a model of interest for use on subsequent efforts. The SEL has undertaken many technology studies while developing operational support systems for numerous NASA spacecraft missions.

Innovation, Novel Solutions and New Devices: The Engines that Drive the Magnetic Storage Industry; Choosing the Right Combination

NASA Astrophysics Data System (ADS)

Marinero, Ernesto E.

2011-03-01

Magnetic storage technology aims to achieve recording densities > 10 12 bits / in 2 intheforeseeablefuture . Thedimensionsofthemagneticdomainsandsensorminimumfeaturesizesatthisdensitywillbe ~ 15 -- 25 nm. These nanoscale dimensions present major challenges for both the materials utilized for magnetic recording, and to the sensors employed to reliably detect the minute magnetic fluxes emanating from such nanoscale domains. These include fundamental physical limits of material properties on account of the reduced dimensionality, as well as nanofabrication challenges to attain the required nanometer feature sizes with the stringent dimensional tolerances required. Since its invention in 1954, the storage density in magnetic recording has incremented by 109 and the cost of storage, measured in MB, has undergone a price reduction of the same order. Impressive as these accomplishments are, is the fact that the fundamental engineering principles of the technology today are essentially the same as when it was invented. This is in spite of numerous efforts to replace it with new alternative technologies or by dire predictions by its own practitioners of its impending death based on perceived limitations. In this talk the state-of-the art and challenges facing the HDD industry in its efforts to continue incrementing the storage density will be discussed. I will illustrate how advances in materials engineering, new physical phenomena and breakthroughs in nanofabrication have facilitated such an impressive technology evolution. Moreover, the key ingredients for said innovations to be implemented as technology solutions will be discussed..

Numerical modelling of river morphodynamics: Latest developments and remaining challenges

NASA Astrophysics Data System (ADS)

Siviglia, Annunziato; Crosato, Alessandra

2016-07-01

Numerical morphodynamic models provide scientific frameworks for advancing our understanding of river systems. The research on involved topics is an important and socially relevant undertaking regarding our environment. Nowadays numerical models are used for different purposes, from answering questions about basic morphodynamic research to managing complex river engineering problems. Due to increasing computer power and the development of advanced numerical techniques, morphodynamic models are now more and more used to predict the bed patterns evolution to a broad spectrum of spatial and temporal scales. The development and the success of application of such models are based upon a wide range of disciplines from applied mathematics for the numerical solution of the equations to geomorphology for the physical interpretation of the results. In this light we organized this special issue (SI) soliciting multidisciplinary contributions which encompass any aspect needed for the development and applications of such models. Most of the papers in the SI stem from contributions to session HS9.5/GM7.11 on numerical modelling and experiments in river morphodynamics at the European Geosciences Union (EGU) General Assembly held in Vienna, April 27th to May 2nd 2014.

Knowledge translation in rehabilitation engineering research and development: a knowledge ecosystem framework.

PubMed

Chau, Tom; Moghimi, Saba; Popovic, Milos R

2013-01-01

Rehabilitation engineering is concerned with technology innovations and technology-mediated treatments for the improvement of quality of care and quality of life of individuals with disability. Unlike many other fields of health research, the knowledge translation (KT) cycle of rehabilitation engineering research and development (R&D) is often considered incomplete until a technology product or technology-facilitated therapy is available to target clientele. As such, the KT journey of rehabilitation engineering R&D is extremely challenging, necessarily involving knowledge exchange among numerous players across multiple sectors. In this article, we draw on recent literature about the knowledge trichotomy in technology-based rehabilitation R&D and propose a knowledge ecosystem to frame the rehabilitation engineering KT process from need to product. Identifying the principal process of the ecosystem as one of knowledge flow, we elucidate the roles of repository and networked knowledge, identify key consumers and producers in a trinity of communities of practice, and draw on knowledge management literature to describe different knowledge flows. The article concludes with instantiations of this knowledge ecosystem for 2 local rehabilitation engineering research-development-commercialization endeavors. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Computing Generalized Matrix Inverse on Spiking Neural Substrate

PubMed Central

Shukla, Rohit; Khoram, Soroosh; Jorgensen, Erik; Li, Jing; Lipasti, Mikko; Wright, Stephen

2018-01-01

Emerging neural hardware substrates, such as IBM's TrueNorth Neurosynaptic System, can provide an appealing platform for deploying numerical algorithms. For example, a recurrent Hopfield neural network can be used to find the Moore-Penrose generalized inverse of a matrix, thus enabling a broad class of linear optimizations to be solved efficiently, at low energy cost. However, deploying numerical algorithms on hardware platforms that severely limit the range and precision of representation for numeric quantities can be quite challenging. This paper discusses these challenges and proposes a rigorous mathematical framework for reasoning about range and precision on such substrates. The paper derives techniques for normalizing inputs and properly quantizing synaptic weights originating from arbitrary systems of linear equations, so that solvers for those systems can be implemented in a provably correct manner on hardware-constrained neural substrates. The analytical model is empirically validated on the IBM TrueNorth platform, and results show that the guarantees provided by the framework for range and precision hold under experimental conditions. Experiments with optical flow demonstrate the energy benefits of deploying a reduced-precision and energy-efficient generalized matrix inverse engine on the IBM TrueNorth platform, reflecting 10× to 100× improvement over FPGA and ARM core baselines. PMID:29593483

Self-deconstructing algae biomass as feedstock for transportation fuels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, Ryan Wesley

The potential for producing biofuels from algae has generated much excitement based on projections of large oil yields with relatively little land use. However, numerous technical challenges remain for achieving market parity with conventional non-renewable liquid fuel sources. Among these challenges, the energy intensive requirements of traditional cell rupture, lipid extraction, and residuals fractioning of microalgae biomass have posed significant challenges to the nascent field of algal biotechnology. Our novel approach to address these problems was to employ low cost solution-state methods and biochemical engineering to eliminate the need for extensive hardware and energy intensive methods for cell rupture, carbohydratemore » and protein solubilization and hydrolysis, and fuel product recovery using consolidated bioprocessing strategies. The outcome of the biochemical deconstruction and conversion process consists of an emulsion of algal lipids and mixed alcohol products from carbohydrate and protein fermentation for co-extraction or in situ transesterification.« less

Improve Data Mining and Knowledge Discovery Through the Use of MatLab

NASA Technical Reports Server (NTRS)

Shaykhian, Gholam Ali; Martin, Dawn (Elliott); Beil, Robert

2011-01-01

Data mining is widely used to mine business, engineering, and scientific data. Data mining uses pattern based queries, searches, or other analyses of one or more electronic databases/datasets in order to discover or locate a predictive pattern or anomaly indicative of system failure, criminal or terrorist activity, etc. There are various algorithms, techniques and methods used to mine data; including neural networks, genetic algorithms, decision trees, nearest neighbor method, rule induction association analysis, slice and dice, segmentation, and clustering. These algorithms, techniques and methods used to detect patterns in a dataset, have been used in the development of numerous open source and commercially available products and technology for data mining. Data mining is best realized when latent information in a large quantity of data stored is discovered. No one technique solves all data mining problems; challenges are to select algorithms or methods appropriate to strengthen data/text mining and trending within given datasets. In recent years, throughout industry, academia and government agencies, thousands of data systems have been designed and tailored to serve specific engineering and business needs. Many of these systems use databases with relational algebra and structured query language to categorize and retrieve data. In these systems, data analyses are limited and require prior explicit knowledge of metadata and database relations; lacking exploratory data mining and discoveries of latent information. This presentation introduces MatLab(R) (MATrix LABoratory), an engineering and scientific data analyses tool to perform data mining. MatLab was originally intended to perform purely numerical calculations (a glorified calculator). Now, in addition to having hundreds of mathematical functions, it is a programming language with hundreds built in standard functions and numerous available toolboxes. MatLab's ease of data processing, visualization and its enormous availability of built in functionalities and toolboxes make it suitable to perform numerical computations and simulations as well as a data mining tool. Engineers and scientists can take advantage of the readily available functions/toolboxes to gain wider insight in their perspective data mining experiments.

Improve Data Mining and Knowledge Discovery through the use of MatLab

NASA Technical Reports Server (NTRS)

Shaykahian, Gholan Ali; Martin, Dawn Elliott; Beil, Robert

2011-01-01

Data mining is widely used to mine business, engineering, and scientific data. Data mining uses pattern based queries, searches, or other analyses of one or more electronic databases/datasets in order to discover or locate a predictive pattern or anomaly indicative of system failure, criminal or terrorist activity, etc. There are various algorithms, techniques and methods used to mine data; including neural networks, genetic algorithms, decision trees, nearest neighbor method, rule induction association analysis, slice and dice, segmentation, and clustering. These algorithms, techniques and methods used to detect patterns in a dataset, have been used in the development of numerous open source and commercially available products and technology for data mining. Data mining is best realized when latent information in a large quantity of data stored is discovered. No one technique solves all data mining problems; challenges are to select algorithms or methods appropriate to strengthen data/text mining and trending within given datasets. In recent years, throughout industry, academia and government agencies, thousands of data systems have been designed and tailored to serve specific engineering and business needs. Many of these systems use databases with relational algebra and structured query language to categorize and retrieve data. In these systems, data analyses are limited and require prior explicit knowledge of metadata and database relations; lacking exploratory data mining and discoveries of latent information. This presentation introduces MatLab(TradeMark)(MATrix LABoratory), an engineering and scientific data analyses tool to perform data mining. MatLab was originally intended to perform purely numerical calculations (a glorified calculator). Now, in addition to having hundreds of mathematical functions, it is a programming language with hundreds built in standard functions and numerous available toolboxes. MatLab's ease of data processing, visualization and its enormous availability of built in functionalities and toolboxes make it suitable to perform numerical computations and simulations as well as a data mining tool. Engineers and scientists can take advantage of the readily available functions/toolboxes to gain wider insight in their perspective data mining experiments.

Human urinary bladder regeneration through tissue engineering - an analysis of 131 clinical cases.

PubMed

Pokrywczynska, Marta; Adamowicz, Jan; Sharma, Arun K; Drewa, Tomasz

2014-03-01

Replacement of urinary bladder tissue with functional equivalents remains one of the most challenging problems of reconstructive urology over the last several decades. The gold standard treatment for urinary diversion after radical cystectomy is the ileal conduit or neobladder; however, this technique is associated with numerous complications including electrolyte imbalances, mucus production, and the potential for malignant transformation. Tissue engineering techniques provide the impetus to construct functional bladder substitutes de novo. Within this review, we have thoroughly perused the literature utilizing PubMed in order to identify clinical studies involving bladder reconstruction utilizing tissue engineering methodologies. The idea of urinary bladder regeneration through tissue engineering dates back to the 1950s. Many natural and synthetic biomaterials such as plastic mold, gelatin sponge, Japanese paper, preserved dog bladder, lyophilized human dura, bovine pericardium, small intestinal submucosa, bladder acellular matrix, or composite of collagen and polyglycolic acid were used for urinary bladder regeneration with a wide range of outcomes. Recent progress in the tissue engineering field suggest that in vitro engineered bladder wall substitutes may have expanded clinical applicability in near future but preclinical investigations on large animal models with defective bladders are necessary to optimize the methods of bladder reconstruction by tissue engineering in humans.

Quantity and unit extraction for scientific and technical intelligence analysis

NASA Astrophysics Data System (ADS)

David, Peter; Hawes, Timothy

2017-05-01

Scientific and Technical (S and T) intelligence analysts consume huge amounts of data to understand how scientific progress and engineering efforts affect current and future military capabilities. One of the most important types of information S and T analysts exploit is the quantities discussed in their source material. Frequencies, ranges, size, weight, power, and numerous other properties and measurements describing the performance characteristics of systems and the engineering constraints that define them must be culled from source documents before quantified analysis can begin. Automating the process of finding and extracting the relevant quantities from a wide range of S and T documents is difficult because information about quantities and their units is often contained in unstructured text with ad hoc conventions used to convey their meaning. Currently, even simple tasks, such as searching for documents discussing RF frequencies in a band of interest, is a labor intensive and error prone process. This research addresses the challenges facing development of a document processing capability that extracts quantities and units from S and T data, and how Natural Language Processing algorithms can be used to overcome these challenges.

Application of soft computing based hybrid models in hydrological variables modeling: a comprehensive review

NASA Astrophysics Data System (ADS)

Fahimi, Farzad; Yaseen, Zaher Mundher; El-shafie, Ahmed

2017-05-01

Since the middle of the twentieth century, artificial intelligence (AI) models have been used widely in engineering and science problems. Water resource variable modeling and prediction are the most challenging issues in water engineering. Artificial neural network (ANN) is a common approach used to tackle this problem by using viable and efficient models. Numerous ANN models have been successfully developed to achieve more accurate results. In the current review, different ANN models in water resource applications and hydrological variable predictions are reviewed and outlined. In addition, recent hybrid models and their structures, input preprocessing, and optimization techniques are discussed and the results are compared with similar previous studies. Moreover, to achieve a comprehensive view of the literature, many articles that applied ANN models together with other techniques are included. Consequently, coupling procedure, model evaluation, and performance comparison of hybrid models with conventional ANN models are assessed, as well as, taxonomy and hybrid ANN models structures. Finally, current challenges and recommendations for future researches are indicated and new hybrid approaches are proposed.

Real Time Optima Tracking Using Harvesting Models of the Genetic Algorithm

NASA Technical Reports Server (NTRS)

Baskaran, Subbiah; Noever, D.

1999-01-01

Tracking optima in real time propulsion control, particularly for non-stationary optimization problems is a challenging task. Several approaches have been put forward for such a study including the numerical method called the genetic algorithm. In brief, this approach is built upon Darwinian-style competition between numerical alternatives displayed in the form of binary strings, or by analogy to 'pseudogenes'. Breeding of improved solution is an often cited parallel to natural selection in.evolutionary or soft computing. In this report we present our results of applying a novel model of a genetic algorithm for tracking optima in propulsion engineering and in real time control. We specialize the algorithm to mission profiling and planning optimizations, both to select reduced propulsion needs through trajectory planning and to explore time or fuel conservation strategies.

Numerical Simulation Of Shock Response To Wall Changes In High Speed Intakes

NASA Astrophysics Data System (ADS)

Fincham, J.; Taylor, N. V.

2011-05-01

Hypersonic flight presents a number of challenges to the designer, one of which is the intake behaviour. Minimising drag requires careful positioning of the intake shock structure, while accurate understanding of the dynamic behaviour is required to allow minimisation of margins. In this paper, a two shock external compression intake derived from the Reaction Engines Limited SABRE engine is examined using inviscid axisymmetric CFD analysis to determine the response of the normal shockwave to axial motion of the intake centrebody. An approximately linear relationship between centrebody position and both the normal shock position and additive drag in steady flow is demonstrated. Initial results from an unsteady analysis are also given, which show complex behaviours may be triggered by rapid motion of the centrebody in response to control input.

Engineering molecular machines

NASA Astrophysics Data System (ADS)

Erman, Burak

2016-04-01

Biological molecular motors use chemical energy, mostly in the form of ATP hydrolysis, and convert it to mechanical energy. Correlated thermal fluctuations are essential for the function of a molecular machine and it is the hydrolysis of ATP that modifies the correlated fluctuations of the system. Correlations are consequences of the molecular architecture of the protein. The idea that synthetic molecular machines may be constructed by designing the proper molecular architecture is challenging. In their paper, Sarkar et al (2016 New J. Phys. 18 043006) propose a synthetic molecular motor based on the coarse grained elastic network model of proteins and show by numerical simulations that motor function is realized, ranging from deterministic to thermal, depending on temperature. This work opens up a new range of possibilities of molecular architecture based engine design.

The development and application of CFD technology in mechanical engineering

NASA Astrophysics Data System (ADS)

Wei, Yufeng

2017-12-01

Computational Fluid Dynamics (CFD) is an analysis of the physical phenomena involved in fluid flow and heat conduction by computer numerical calculation and graphical display. The numerical method simulates the complexity of the physical problem and the precision of the numerical solution, which is directly related to the hardware speed of the computer and the hardware such as memory. With the continuous improvement of computer performance and CFD technology, it has been widely applied to the field of water conservancy engineering, environmental engineering and industrial engineering. This paper summarizes the development process of CFD, the theoretical basis, the governing equations of fluid mechanics, and introduces the various methods of numerical calculation and the related development of CFD technology. Finally, CFD technology in the mechanical engineering related applications are summarized. It is hoped that this review will help researchers in the field of mechanical engineering.

A numerical simulation method and analysis of a complete thermoacoustic-Stirling engine.

PubMed

Ling, Hong; Luo, Ercang; Dai, Wei

2006-12-22

Thermoacoustic prime movers can generate pressure oscillation without any moving parts on self-excited thermoacoustic effect. The details of the numerical simulation methodology for thermoacoustic engines are presented in the paper. First, a four-port network method is used to build the transcendental equation of complex frequency as a criterion to judge if temperature distribution of the whole thermoacoustic system is correct for the case with given heating power. Then, the numerical simulation of a thermoacoustic-Stirling heat engine is carried out. It is proved that the numerical simulation code can run robustly and output what one is interested in. Finally, the calculated results are compared with the experiments of the thermoacoustic-Stirling heat engine (TASHE). It shows that the numerical simulation can agrees with the experimental results with acceptable accuracy.

Three-dimensional transient numerical simulation for intake process in the engine intake port-valve-cylinder system.

PubMed

Luo, Ma-Ji; Chen, Guo-Hua; Ma, Yuan-Hao

2003-01-01

This paper presents a KIVA-3 code based numerical model for three-dimensional transient intake flow in the intake port-valve-cylinder system of internal combustion engine using body-fitted technique, which can be used in numerical study on internal combustion engine with vertical and inclined valves, and has higher calculation precision. A numerical simulation (on the intake process of a two-valve engine with a semi-sphere combustion chamber and a radial intake port) is provided for analysis of the velocity field and pressure field of different plane at different crank angles. The results revealed the formation of the tumble motion, the evolution of flow field parameters and the variation of tumble ratios as important information for the design of engine intake system.

Distinctions between intelligent manufactured and constructed systems and a new discipline for intelligent infrastructure hypersystems

NASA Astrophysics Data System (ADS)

Aktan, A. Emin

2003-08-01

Although the interconnected systems nature of the infrastructures, and the complexity of interactions between their engineered, socio-technical and natural constituents have been recognized for some time, the principles of effectively operating, protecting and preserving such systems by taking full advantage of "modeling, simulations, optimization, control and decision making" tools developed by the systems engineering and operations research community have not been adequately studied or discussed by many engineers including the writer. Differential and linear equation systems, numerical and finite element modeling techniques, statistical and probabilistic representations are universal, however, different disciplines have developed their distinct approaches to conceptualizing, idealizing and modeling the systems they commonly deal with. The challenge is in adapting and integrating deterministic and stochastic, geometric and numerical, physics-based and "soft (data-or-knowledge based)", macroscopic or microscopic models developed by various disciplines for simulating infrastructure systems. There is a lot to be learned by studying how different disciplines have studied, improved and optimized the systems relating to various processes and products in their domains. Operations research has become a fifty-year old discipline addressing complex systems problems. Its mathematical tools range from linear programming to decision processes and game theory. These tools are used extensively in management and finance, as well as by industrial engineers for optimizing and quality control. Progressive civil engineering academic programs have adopted "systems engineering" as a focal area. However, most of the civil engineering systems programs remain focused on constructing and analyzing highly idealized, often generic models relating to the planning or operation of transportation, water or waste systems, maintenance management, waste management or general infrastructure hazards risk management. We further note that in the last decade there have been efforts for "agent-based" modeling of synthetic infrastructure systems by taking advantage of supercomputers at various DOE Laboratories. However, whether there is any similitude between such synthetic and actual systems needs investigating further.

Navigating through 'a labyrinth' of guidance.

PubMed

Pearson, Susan

2014-09-01

Devising a strategy to deliver safe water to thousands of outlets spread across numerous buildings is always going to be a challenge, so how do you navigate your way through a bewildering labyrinth of sometimes contradictory guidance documents? Is there, in fact, simply too much guidance? Posing this question at a recent one-day conference on waterborne infections in healthcare facilities, Paul Nolan, authorised water engineer (AE), and operations manager for PFI provider, Lend Lease, took delegates through a review of the latest guidance and regulations, as Susan Pearson reports.

Engineering strategies for the fermentative production of plant alkaloids in yeast.

PubMed

Trenchard, Isis J; Smolke, Christina D

2015-07-01

Microbial hosts engineered for the biosynthesis of plant natural products offer enormous potential as powerful discovery and production platforms. However, the reconstruction of these complex biosynthetic schemes faces numerous challenges due to the number of enzymatic steps and challenging enzyme classes associated with these pathways, which can lead to issues in metabolic load, pathway specificity, and maintaining flux to desired products. Cytochrome P450 enzymes are prevalent in plant specialized metabolism and are particularly difficult to express heterologously. Here, we describe the reconstruction of the sanguinarine branch of the benzylisoquinoline alkaloid pathway in Saccharomyces cerevisiae, resulting in microbial biosynthesis of protoberberine, protopine, and benzophenanthridine alkaloids through to the end-product sanguinarine, which we demonstrate can be efficiently produced in yeast in the absence of the associated biosynthetic enzyme. We achieved titers of 676 μg/L stylopine, 548 μg/L cis-N-methylstylopine, 252 μg/L protopine, and 80 μg/L sanguinarine from the engineered yeast strains. Through our optimization efforts, we describe genetic and culture strategies supporting the functional expression of multiple plant cytochrome P450 enzymes in the context of a large multi-step pathway. Our results also provided insight into relationships between cytochrome P450 activity and yeast ER physiology. We were able to improve the production of critical intermediates by 32-fold through genetic techniques and an additional 45-fold through culture optimization. Copyright © 2015 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

iSTEM: The Aerospace Engineering Challenge

ERIC Educational Resources Information Center

English, Lyn D.; King, Donna T.; Hudson, Peter; Dawes, Les

2014-01-01

The authors developed The Paper Plane Challenge as one of a three-part response to The Aerospace Engineering Challenge. The Aerospace Engineering Challenge was the second of three multi-part activities that they had developed with the teachers during the year. Their aim was to introduce students to the exciting world of engineering, where they…

The acquisition and transfer of knowledge of electrokinetic-hydrodynamics (EKHD) fundamentals: an introductory graduate-level course

NASA Astrophysics Data System (ADS)

Pascal, Jennifer; Tíjaro-Rojas, Rocío; Oyanader, Mario A.; Arce, Pedro E.

2017-09-01

Relevant engineering applications, such as bioseparation of proteins and DNA, soil-cleaning, motion of colloidal particles in different media, electrical field-based cancer treatments, and the cleaning of surfaces and coating flows, belongs to the family of 'Applied Field Sensitive Process Technologies' requiring an external field to move solutes in a fluid within a fibrous (or porous) domain. This field incorporates an additional variable that makes the analysis very challenging and can create for the student a number of new problems to solve. A graduate-level course, based on active-learning approaches and High Performance Learning Environments, where transfer of knowledge plays a key role, was designed by the Chemical Engineering Department at Tennessee Technological University. This course, where the fundamentals principles of EKHD were taught to science, engineering and technology students was designed by the Chemical Engineering Department at the Tennessee Technological University, Cookeville, TN. An important number of these students were able to grasp the tools required to advance their research projects that led to numerous technical presentations in professional society meetings and publications in peered-reviewed journals.

Pseudo-shock waves and their interactions in high-speed intakes

NASA Astrophysics Data System (ADS)

Gnani, F.; Zare-Behtash, H.; Kontis, K.

2016-04-01

In an air-breathing engine the flow deceleration from supersonic to subsonic conditions takes places inside the isolator through a gradual compression consisting of a series of shock waves. The wave system, referred to as a pseudo-shock wave or shock train, establishes the combustion chamber entrance conditions, and therefore influences the performance of the entire propulsion system. The characteristics of the pseudo-shock depend on a number of variables which make this flow phenomenon particularly challenging to be analysed. Difficulties in experimentally obtaining accurate flow quantities at high speeds and discrepancies of numerical approaches with measured data have been readily reported. Understanding the flow physics in the presence of the interaction of numerous shock waves with the boundary layer in internal flows is essential to developing methods and control strategies. To counteract the negative effects of shock wave/boundary layer interactions, which are responsible for the engine unstart process, multiple flow control methodologies have been proposed. Improved analytical models, advanced experimental methodologies and numerical simulations have allowed a more in-depth analysis of the flow physics. The present paper aims to bring together the main results, on the shock train structure and its associated phenomena inside isolators, studied using the aforementioned tools. Several promising flow control techniques that have more recently been applied to manipulate the shock wave/boundary layer interaction are also examined in this review.

Nanomaterials for Engineering Stem Cell Responses.

PubMed

Kerativitayanan, Punyavee; Carrow, James K; Gaharwar, Akhilesh K

2015-08-05

Recent progress in nanotechnology has stimulated the development of multifunctional biomaterials for tissue engineering applications. Synergistic interactions between nanomaterials and stem cell engineering offer numerous possibilities to address some of the daunting challenges in regenerative medicine, such as controlling trigger differentiation, immune reactions, limited supply of stem cells, and engineering complex tissue structures. Specifically, the interactions between stem cells and their microenvironment play key roles in controlling stem cell fate, which underlines therapeutic success. However, the interactions between nanomaterials and stem cells are not well understood, and the effects of the nanomaterials shape, surface morphology, and chemical functionality on cellular processes need critical evaluation. In this Review, focus is put on recent development in nanomaterial-stem cell interactions, with specific emphasis on their application in regenerative medicine. Further, the emerging technologies based on nanomaterials developed over the past decade for stem cell engineering are reviewed, as well as the potential applications of these nanomaterials in tissue regeneration, stem cell isolation, and drug/gene delivery. It is anticipated that the enhanced understanding of nanomaterial-stem cell interactions will facilitate improved biomaterial design for a range of biomedical and biotechnological applications. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bio-inspired 3D microenvironments: a new dimension in tissue engineering.

PubMed

Magin, Chelsea M; Alge, Daniel L; Anseth, Kristi S

2016-03-04

Biomaterial scaffolds have been a foundational element of the tissue engineering paradigm since the inception of the field. Over the years there has been a progressive move toward the rational design and fabrication of bio-inspired materials that mimic the composition as well as the architecture and 3D structure of tissues. In this review, we chronicle advances in the field that address key challenges in tissue engineering as well as some emerging applications. Specifically, a summary of the materials and chemistries used to engineer bio-inspired 3D matrices that mimic numerous aspects of the extracellular matrix is provided, along with an overview of bioprinting, an additive manufacturing approach, for the fabrication of engineered tissues with precisely controlled 3D structures and architectures. To emphasize the potential clinical impact of the bio-inspired paradigm in biomaterials engineering, some applications of bio-inspired matrices are discussed in the context of translational tissue engineering. However, focus is also given to recent advances in the use of engineered 3D cellular microenvironments for fundamental studies in cell biology, including photoresponsive systems that are shedding new light on how matrix properties influence cell phenotype and function. In an outlook for future work, the need for high-throughput methods both for screening and fabrication is highlighted. Finally, microscale organ-on-a-chip technologies are highlighted as a promising area for future investment in the application of bio-inspired microenvironments.

PARALLEL PERTURBATION MODEL FOR CYCLE TO CYCLE VARIABILITY PPM4CCV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ameen, Muhsin Mohammed; Som, Sibendu

This code consists of a Fortran 90 implementation of the parallel perturbation model to compute cyclic variability in spark ignition (SI) engines. Cycle-to-cycle variability (CCV) is known to be detrimental to SI engine operation resulting in partial burn and knock, and result in an overall reduction in the reliability of the engine. Numerical prediction of cycle-to-cycle variability (CCV) in SI engines is extremely challenging for two key reasons: (i) high-fidelity methods such as large eddy simulation (LES) are required to accurately capture the in-cylinder turbulent flow field, and (ii) CCV is experienced over long timescales and hence the simulations needmore » to be performed for hundreds of consecutive cycles. In the new technique, the strategy is to perform multiple parallel simulations, each of which encompasses 2-3 cycles, by effectively perturbing the simulation parameters such as the initial and boundary conditions. The PPM4CCV code is a pre-processing code and can be coupled with any engine CFD code. PPM4CCV was coupled with Converge CFD code and a 10-time speedup was demonstrated over the conventional multi-cycle LES in predicting the CCV for a motored engine. Recently, the model is also being applied to fired engines including port fuel injected (PFI) and direct injection spark ignition engines and the preliminary results are very encouraging.« less

The Australian Computational Earth Systems Simulator

NASA Astrophysics Data System (ADS)

Mora, P.; Muhlhaus, H.; Lister, G.; Dyskin, A.; Place, D.; Appelbe, B.; Nimmervoll, N.; Abramson, D.

2001-12-01

Numerical simulation of the physics and dynamics of the entire earth system offers an outstanding opportunity for advancing earth system science and technology but represents a major challenge due to the range of scales and physical processes involved, as well as the magnitude of the software engineering effort required. However, new simulation and computer technologies are bringing this objective within reach. Under a special competitive national funding scheme to establish new Major National Research Facilities (MNRF), the Australian government together with a consortium of Universities and research institutions have funded construction of the Australian Computational Earth Systems Simulator (ACcESS). The Simulator or computational virtual earth will provide the research infrastructure to the Australian earth systems science community required for simulations of dynamical earth processes at scales ranging from microscopic to global. It will consist of thematic supercomputer infrastructure and an earth systems simulation software system. The Simulator models and software will be constructed over a five year period by a multi-disciplinary team of computational scientists, mathematicians, earth scientists, civil engineers and software engineers. The construction team will integrate numerical simulation models (3D discrete elements/lattice solid model, particle-in-cell large deformation finite-element method, stress reconstruction models, multi-scale continuum models etc) with geophysical, geological and tectonic models, through advanced software engineering and visualization technologies. When fully constructed, the Simulator aims to provide the software and hardware infrastructure needed to model solid earth phenomena including global scale dynamics and mineralisation processes, crustal scale processes including plate tectonics, mountain building, interacting fault system dynamics, and micro-scale processes that control the geological, physical and dynamic behaviour of earth systems. ACcESS represents a part of Australia's contribution to the APEC Cooperation for Earthquake Simulation (ACES) international initiative. Together with other national earth systems science initiatives including the Japanese Earth Simulator and US General Earthquake Model projects, ACcESS aims to provide a driver for scientific advancement and technological breakthroughs including: quantum leaps in understanding of earth evolution at global, crustal, regional and microscopic scales; new knowledge of the physics of crustal fault systems required to underpin the grand challenge of earthquake prediction; new understanding and predictive capabilities of geological processes such as tectonics and mineralisation.

Implicit Large Eddy Simulation of a wingtip vortex at Rec =1.2x106

NASA Astrophysics Data System (ADS)

Lombard, Jean-Eloi; Moxey, Dave; Sherwin, Spencer; SherwinLab Team

2015-11-01

We present recent developments in numerical methods for performing a Large Eddy Simulation (LES) of the formation and evolution of a wingtip vortex. The development of these vortices in the near wake, in combination with the large Reynolds numbers present in these cases, make these types of test cases particularly challenging to investigate numerically. To demonstrate the method's viability, we present results from numerical simulations of flow over a NACA 0012 profile wingtip at Rec = 1.2 x106 and compare them against experimental data, which is to date the highest Reynolds number achieved for a LES that has been correlated with experiments for this test case. Our model correlates favorably with experiment, both for the characteristic jetting in the primary vortex and pressure distribution on the wing surface. The proposed method is of general interest for the modeling of transitioning vortex dominated flows over complex geometries. McLaren Racing/Royal Academy of Engineering Research Chair.

Towards Test Driven Development for Computational Science with pFUnit

NASA Technical Reports Server (NTRS)

Rilee, Michael L.; Clune, Thomas L.

2014-01-01

Developers working in Computational Science & Engineering (CSE)/High Performance Computing (HPC) must contend with constant change due to advances in computing technology and science. Test Driven Development (TDD) is a methodology that mitigates software development risks due to change at the cost of adding comprehensive and continuous testing to the development process. Testing frameworks tailored for CSE/HPC, like pFUnit, can lower the barriers to such testing, yet CSE software faces unique constraints foreign to the broader software engineering community. Effective testing of numerical software requires a comprehensive suite of oracles, i.e., use cases with known answers, as well as robust estimates for the unavoidable numerical errors associated with implementation with finite-precision arithmetic. At first glance these concerns often seem exceedingly challenging or even insurmountable for real-world scientific applications. However, we argue that this common perception is incorrect and driven by (1) a conflation between model validation and software verification and (2) the general tendency in the scientific community to develop relatively coarse-grained, large procedures that compound numerous algorithmic steps.We believe TDD can be applied routinely to numerical software if developers pursue fine-grained implementations that permit testing, neatly side-stepping concerns about needing nontrivial oracles as well as the accumulation of errors. We present an example of a successful, complex legacy CSE/HPC code whose development process shares some aspects with TDD, which we contrast with current and potential capabilities. A mix of our proposed methodology and framework support should enable everyday use of TDD by CSE-expert developers.

Engineering control of bacterial cellulose production using a genetic toolkit and a new cellulose-producing strain

PubMed Central

Florea, Michael; Hagemann, Henrik; Santosa, Gabriella; Micklem, Chris N.; Spencer-Milnes, Xenia; de Arroyo Garcia, Laura; Paschou, Despoina; Lazenbatt, Christopher; Kong, Deze; Chughtai, Haroon; Jensen, Kirsten; Freemont, Paul S.; Kitney, Richard; Reeve, Benjamin; Ellis, Tom

2016-01-01

Bacterial cellulose is a strong and ultrapure form of cellulose produced naturally by several species of the Acetobacteraceae. Its high strength, purity, and biocompatibility make it of great interest to materials science; however, precise control of its biosynthesis has remained a challenge for biotechnology. Here we isolate a strain of Komagataeibacter rhaeticus (K. rhaeticus iGEM) that can produce cellulose at high yields, grow in low-nitrogen conditions, and is highly resistant to toxic chemicals. We achieved external control over its bacterial cellulose production through development of a modular genetic toolkit that enables rational reprogramming of the cell. To further its use as an organism for biotechnology, we sequenced its genome and demonstrate genetic circuits that enable functionalization and patterning of heterologous gene expression within the cellulose matrix. This work lays the foundations for using genetic engineering to produce cellulose-based materials, with numerous applications in basic science, materials engineering, and biotechnology. PMID:27247386

Engineering control of bacterial cellulose production using a genetic toolkit and a new cellulose-producing strain.

PubMed

Florea, Michael; Hagemann, Henrik; Santosa, Gabriella; Abbott, James; Micklem, Chris N; Spencer-Milnes, Xenia; de Arroyo Garcia, Laura; Paschou, Despoina; Lazenbatt, Christopher; Kong, Deze; Chughtai, Haroon; Jensen, Kirsten; Freemont, Paul S; Kitney, Richard; Reeve, Benjamin; Ellis, Tom

2016-06-14

Bacterial cellulose is a strong and ultrapure form of cellulose produced naturally by several species of the Acetobacteraceae Its high strength, purity, and biocompatibility make it of great interest to materials science; however, precise control of its biosynthesis has remained a challenge for biotechnology. Here we isolate a strain of Komagataeibacter rhaeticus (K. rhaeticus iGEM) that can produce cellulose at high yields, grow in low-nitrogen conditions, and is highly resistant to toxic chemicals. We achieved external control over its bacterial cellulose production through development of a modular genetic toolkit that enables rational reprogramming of the cell. To further its use as an organism for biotechnology, we sequenced its genome and demonstrate genetic circuits that enable functionalization and patterning of heterologous gene expression within the cellulose matrix. This work lays the foundations for using genetic engineering to produce cellulose-based materials, with numerous applications in basic science, materials engineering, and biotechnology.

Metabolic engineering of yeast for lignocellulosic biofuel production.

PubMed

Jin, Yong-Su; Cate, Jamie Hd

2017-12-01

Production of biofuels from lignocellulosic biomass remains an unsolved challenge in industrial biotechnology. Efforts to use yeast for conversion face the question of which host organism to use, counterbalancing the ease of genetic manipulation with the promise of robust industrial phenotypes. Saccharomyces cerevisiae remains the premier host for metabolic engineering of biofuel pathways, due to its many genetic, systems and synthetic biology tools. Numerous engineering strategies for expanding substrate ranges and diversifying products of S. cerevisiae have been developed. Other yeasts generally lack these tools, yet harbor superior phenotypes that could be exploited in the harsh processes required for lignocellulosic biofuel production. These include thermotolerance, resistance to toxic compounds generated during plant biomass deconstruction, and wider carbon consumption capabilities. Although promising, these yeasts have yet to be widely exploited. By contrast, oleaginous yeasts such as Yarrowia lipolytica capable of producing high titers of lipids are rapidly advancing in terms of the tools available for their metabolic manipulation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Modeling the Impact of Deformation on Unstable Miscible Displacements in Porous Media

NASA Astrophysics Data System (ADS)

Santillán, D.; Cueto-Felgueroso, L.

2014-12-01

Coupled flow and geomechanics is a critical research challenge in engineering and the geosciences. The simultaneous flow of two or more fluids with different densities or viscosities through deformable media is ubiquitous in environmental, industrial, and biological processes, including the removal of non-aqueous phase liquids from underground water bodies, the geological storage of CO2, and current challenges in energy technologies, such as enhanced geothermal systems, unconventional hydrocarbon resources or enhanced oil recovery techniques. Using numerical simulation, we study the interplay between viscous-driven flow instabilities (viscous fingering) and rock mechanics, and elucidate the structure of the displacement patterns as a function of viscosity contrast, injection rate and rock mechanical properties. Finally, we discuss the role of medium deformation on transport and mixing processes in porous media.

Numerical Modeling of Fuel Injection into an Accelerating, Turning Flow with a Cavity

NASA Astrophysics Data System (ADS)

Colcord, Ben James

Deliberate continuation of the combustion in the turbine passages of a gas turbine engine has the potential to increase the efficiency and the specific thrust or power of current gas-turbine engines. This concept, known as a turbine-burner, must overcome many challenges before becoming a viable product. One major challenge is the injection, mixing, ignition, and burning of fuel within a short residence time in a turbine passage characterized by large three-dimensional accelerations. One method of increasing the residence time is to inject the fuel into a cavity adjacent to the turbine passage, creating a low-speed zone for mixing and combustion. This situation is simulated numerically, with the turbine passage modeled as a turning, converging channel flow of high-temperature, vitiated air adjacent to a cavity. Both two- and three-dimensional, reacting and non-reacting calculations are performed, examining the effects of channel curvature and convergence, fuel and additional air injection configurations, and inlet conditions. Two-dimensional, non-reacting calculations show that higher aspect ratio cavities improve the fluid interaction between the channel flow and the cavity, and that the cavity dimensions are important for enhancing the mixing. Two-dimensional, reacting calculations show that converging channels improve the combustion efficiency. Channel curvature can be either beneficial or detrimental to combustion efficiency, depending on the location of the cavity and the fuel and air injection configuration. Three-dimensional, reacting calculations show that injecting fuel and air so as to disrupt the natural motion of the cavity stimulates three-dimensional instability and improves the combustion efficiency.

LLIMAS: Revolutionizing integrating modeling and analysis at MIT Lincoln Laboratory

NASA Astrophysics Data System (ADS)

Doyle, Keith B.; Stoeckel, Gerhard P.; Rey, Justin J.; Bury, Mark E.

2017-08-01

MIT Lincoln Laboratory's Integrated Modeling and Analysis Software (LLIMAS) enables the development of novel engineering solutions for advanced prototype systems through unique insights into engineering performance and interdisciplinary behavior to meet challenging size, weight, power, environmental, and performance requirements. LLIMAS is a multidisciplinary design optimization tool that wraps numerical optimization algorithms around an integrated framework of structural, thermal, optical, stray light, and computational fluid dynamics analysis capabilities. LLIMAS software is highly extensible and has developed organically across a variety of technologies including laser communications, directed energy, photometric detectors, chemical sensing, laser radar, and imaging systems. The custom software architecture leverages the capabilities of existing industry standard commercial software and supports the incorporation of internally developed tools. Recent advances in LLIMAS's Structural-Thermal-Optical Performance (STOP), aeromechanical, and aero-optical capabilities as applied to Lincoln prototypes are presented.

A heuristic approach to optimization of structural topology including self-weight

NASA Astrophysics Data System (ADS)

Tajs-Zielińska, Katarzyna; Bochenek, Bogdan

2018-01-01

Topology optimization of structures under a design-dependent self-weight load is investigated in this paper. The problem deserves attention because of its significant importance in the engineering practice, especially nowadays as topology optimization is more often applied when designing large engineering structures, for example, bridges or carrying systems of tall buildings. It is worth noting that well-known approaches of topology optimization which have been successfully applied to structures under fixed loads cannot be directly adapted to the case of design-dependent loads, so that topology generation can be a challenge also for numerical algorithms. The paper presents the application of a simple but efficient non-gradient method to topology optimization of elastic structures under self-weight loading. The algorithm is based on the Cellular Automata concept, the application of which can produce effective solutions with low computational cost.

The Small Helm Project: an academic activity addressing international corruption for undergraduate civil engineering and construction management students.

PubMed

Benzley, Steven E

2006-04-01

This paper presents an academic project that addresses the issue of international corruption in the engineering and construction industry, in a manner that effectively incorporates several learning experiences. The major objectives of the project are to provide the students a learning activity that will 1) make a meaningful contribution within the disciplines being studied; 2) teach by experience a significant principle that can be valuable in numerous situations during an individual's career, and 3) engage the minds, experiences, and enthusiasm of the participants in a real ethical challenge that is prevalent in all of their chosen professional fields. The paper describes the full details of the project, the actual implementation of it during Winter Semester 2005, the experiences gained during the initial trial, and the modifications and improvements incorporated for future implementation.

A review on the mechanical design elements of ankle rehabilitation robot.

PubMed

Khalid, Yusuf M; Gouwanda, Darwin; Parasuraman, Subramanian

2015-06-01

Ankle rehabilitation robots are developed to enhance ankle strength, flexibility and proprioception after injury and to promote motor learning and ankle plasticity in patients with drop foot. This article reviews the design elements that have been incorporated into the existing robots, for example, backdrivability, safety measures and type of actuation. It also discusses numerous challenges faced by engineers in designing this robot, including robot stability and its dynamic characteristics, universal evaluation criteria to assess end-user comfort, safety and training performance and the scientific basis on the optimal rehabilitation strategies to improve ankle condition. This article can serve as a reference to design robot with better stability and dynamic characteristics and good safety measures against internal and external events. It can also serve as a guideline for the engineers to report their designs and findings. © IMechE 2015.

Navigating Transitions: Challenges for Engineering Students

ERIC Educational Resources Information Center

Moore-Russo, Deborah; Wilsey, Jillian N.; Parthum, Michael J., Sr.; Lewis, Kemper

2017-01-01

As college students enter engineering, they face challenges when they navigate across various transitions. These challenges impact whether a student can successfully adapt to the rigorous curricular requirements of an engineering degree and to the norms and expectations that are particular to engineering. This article focuses on the transitions…

Engineering strategies for the fermentative production of plant alkaloids in yeast

PubMed Central

Trenchard, Isis J.; Smolke, Christina D.

2015-01-01

Microbial hosts engineered for the biosynthesis of plant natural products offer enormous potential as powerful discovery and production platforms. However, the reconstruction of these complex biosynthetic schemes faces numerous challenges due to the number of enzymatic steps and challenging enzyme classes associated with these pathways, which can lead to issues in metabolic load, pathway specificity, and maintaining flux to desired products. Cytochrome P450 enzymes are prevalent in plant specialized metabolism and are particularly difficult to express heterologously. Here, we describe the reconstruction of the sanguinarine branch of the benzylisoquinoline alkaloid pathway in Saccharomyces cerevisiae, resulting in microbial biosynthesis of protoberberine, protopine, and benzophenanthridine alkaloids through to the end-product sanguinarine, which we demonstrate can be efficiently produced in yeast in the absence of the associated biosynthetic enzyme. We achieved titers of 676 µg/L stylopine, 548 µg/L cis-N-methylstylopine, 252 µg/L protopine, and 80 µg/L sanguinarine from the engineered yeast strains. Through our optimization efforts, we describe genetic and culture strategies supporting the functional expression of multiple plant cytochrome P450 enzymes in the context of a large multi-step pathway. Our results also provided insight into relationships between cytochrome P450 activity and yeast ER physiology. We were able to improve the production of critical intermediates by 32-fold through genetic techniques and an additional 45-fold through culture optimization. PMID:25981946

Challenges for Engineering Design, Construction, and Maintenance of Infrastructure in Afghanistan

DTIC Science & Technology

2010-11-01

applied engineering expertise that collectively can solve challenging infra- structure problems. USACE-ERDC’s researchers and engineers are field...Development Center (ERDC) possesses a unique combination of basic research and applied engineering expertise that collectively can solve challenging...restoration, and other projects. The USACE Engineer Research and Development Center (ERDC) possesses a unique combination of basic research and applied

U.S. Army Armament Research, Development and Engineering Center Grain Evaluation Software to Numerically Predict Linear Burn Regression for Solid Propellant Grain Geometries

DTIC Science & Technology

2017-10-01

ENGINEERING CENTER GRAIN EVALUATION SOFTWARE TO NUMERICALLY PREDICT LINEAR BURN REGRESSION FOR SOLID PROPELLANT GRAIN GEOMETRIES Brian...author(s) and should not be construed as an official Department of the Army position, policy, or decision, unless so designated by other documentation...U.S. ARMY ARMAMENT RESEARCH, DEVELOPMENT AND ENGINEERING CENTER GRAIN EVALUATION SOFTWARE TO NUMERICALLY PREDICT LINEAR BURN REGRESSION FOR SOLID

Value-Engineering Review for Numerical Control

NASA Technical Reports Server (NTRS)

Warner, J. L.

1984-01-01

Selecting parts for conversion from conventional machining to numerical control, value-engineering review performed for every part to identify potential changes to part design that result in increased production efficiency.

Rocket engine numerical simulator

NASA Technical Reports Server (NTRS)

Davidian, Ken

1993-01-01

The topics are presented in viewgraph form and include the following: a rocket engine numerical simulator (RENS) definition; objectives; justification; approach; potential applications; potential users; RENS work flowchart; RENS prototype; and conclusion.

Numerical Zooming Between a NPSS Engine System Simulation and a One-Dimensional High Compressor Analysis Code

NASA Technical Reports Server (NTRS)

Follen, Gregory; auBuchon, M.

2000-01-01

Within NASA's High Performance Computing and Communication (HPCC) program, NASA Glenn Research Center is developing an environment for the analysis/design of aircraft engines called the Numerical Propulsion System Simulation (NPSS). NPSS focuses on the integration of multiple disciplines such as aerodynamics, structures, and heat transfer along with the concept of numerical zooming between zero-dimensional to one-, two-, and three-dimensional component engine codes. In addition, the NPSS is refining the computing and communication technologies necessary to capture complex physical processes in a timely and cost-effective manner. The vision for NPSS is to create a "numerical test cell" enabling full engine simulations overnight on cost-effective computing platforms. Of the different technology areas that contribute to the development of the NPSS Environment, the subject of this paper is a discussion on numerical zooming between a NPSS engine simulation and higher fidelity representations of the engine components (fan, compressor, burner, turbines, etc.). What follows is a description of successfully zooming one-dimensional (row-by-row) high-pressure compressor analysis results back to a zero-dimensional NPSS engine simulation and a discussion of the results illustrated using an advanced data visualization tool. This type of high fidelity system-level analysis, made possible by the zooming capability of the NPSS, will greatly improve the capability of the engine system simulation and increase the level of virtual test conducted prior to committing the design to hardware.

Interaction design challenges and solutions for ALMA operations monitoring and control

NASA Astrophysics Data System (ADS)

Pietriga, Emmanuel; Cubaud, Pierre; Schwarz, Joseph; Primet, Romain; Schilling, Marcus; Barkats, Denis; Barrios, Emilio; Vila Vilaro, Baltasar

2012-09-01

The ALMA radio-telescope, currently under construction in northern Chile, is a very advanced instrument that presents numerous challenges. From a software perspective, one critical issue is the design of graphical user interfaces for operations monitoring and control that scale to the complexity of the system and to the massive amounts of data users are faced with. Early experience operating the telescope with only a few antennas has shown that conventional user interface technologies are not adequate in this context. They consume too much screen real-estate, require many unnecessary interactions to access relevant information, and fail to provide operators and astronomers with a clear mental map of the instrument. They increase extraneous cognitive load, impeding tasks that call for quick diagnosis and action. To address this challenge, the ALMA software division adopted a user-centered design approach. For the last two years, astronomers, operators, software engineers and human-computer interaction researchers have been involved in participatory design workshops, with the aim of designing better user interfaces based on state-of-the-art visualization techniques. This paper describes the process that led to the development of those interface components and to a proposal for the science and operations console setup: brainstorming sessions, rapid prototyping, joint implementation work involving software engineers and human-computer interaction researchers, feedback collection from a broader range of users, further iterations and testing.

Many-Body Subradiant Excitations in Metamaterial Arrays: Experiment and Theory.

PubMed

Jenkins, Stewart D; Ruostekoski, Janne; Papasimakis, Nikitas; Savo, Salvatore; Zheludev, Nikolay I

2017-08-04

Subradiant excitations, originally predicted by Dicke, have posed a long-standing challenge in physics owing to their weak radiative coupling to environment. Here we engineer massive coherently driven classical subradiance in planar metamaterial arrays as a spatially extended eigenmode comprising over 1000 metamolecules. By comparing the near- and far-field response in large-scale numerical simulations with those in experimental observations we identify strong evidence for classically correlated multimetamolecule subradiant states that dominate the total excitation energy. We show that similar spatially extended many-body subradiance can also exist in plasmonic metamaterial arrays at optical frequencies.

The potential impact of the preparation rich in growth factors (PRGF) in different medical fields.

PubMed

Anitua, Eduardo; Sánchez, Mikel; Orive, Gorka; Andía, Isabel

2007-11-01

Platelet-rich preparations constitute a relatively new biotechnology for the stimulation and acceleration of tissue healing and bone regeneration. The versatility and biocompatibility of this approach has stimulated its therapeutic use in numerous medical and scientific fields including dentistry, oral implantology, orthopaedics, ulcer treatment, tissue engineering among others. Here we discuss the important progress that has been accomplished in the field of platelet-rich preparations in the last few years. Some of the most interesting therapeutic applications of this technology are discussed as are some of the limitations, future challenges and directions in the field.

Multiaxial and Thermomechanical Fatigue of Materials: A Historical Perspective and Some Future Challenges

NASA Technical Reports Server (NTRS)

Kalluri, Sreeramesh

2013-01-01

Structural materials used in engineering applications routinely subjected to repetitive mechanical loads in multiple directions under non-isothermal conditions. Over past few decades, several multiaxial fatigue life estimation models (stress- and strain-based) developed for isothermal conditions. Historically, numerous fatigue life prediction models also developed for thermomechanical fatigue (TMF) life prediction, predominantly for uniaxial mechanical loading conditions. Realistic structural components encounter multiaxial loads and non-isothermal loading conditions, which increase potential for interaction of damage modes. A need exists for mechanical testing and development verification of life prediction models under such conditions.

Modelling DC responses of 3D complex fracture networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beskardes, Gungor Didem; Weiss, Chester Joseph

Here, the determination of the geometrical properties of fractures plays a critical role in many engineering problems to assess the current hydrological and mechanical states of geological media and to predict their future states. However, numerical modeling of geoelectrical responses in realistic fractured media has been challenging due to the explosive computational cost imposed by the explicit discretizations of fractures at multiple length scales, which often brings about a tradeoff between computational efficiency and geologic realism. Here, we use the hierarchical finite element method to model electrostatic response of realistically complex 3D conductive fracture networks with minimal computational cost.

Modelling DC responses of 3D complex fracture networks

DOE PAGES

Beskardes, Gungor Didem; Weiss, Chester Joseph

2018-03-01

Here, the determination of the geometrical properties of fractures plays a critical role in many engineering problems to assess the current hydrological and mechanical states of geological media and to predict their future states. However, numerical modeling of geoelectrical responses in realistic fractured media has been challenging due to the explosive computational cost imposed by the explicit discretizations of fractures at multiple length scales, which often brings about a tradeoff between computational efficiency and geologic realism. Here, we use the hierarchical finite element method to model electrostatic response of realistically complex 3D conductive fracture networks with minimal computational cost.

Software Engineering Support of the Third Round of Scientific Grand Challenge Investigations: Earth System Modeling Software Framework Survey

NASA Technical Reports Server (NTRS)

Talbot, Bryan; Zhou, Shu-Jia; Higgins, Glenn; Zukor, Dorothy (Technical Monitor)

2002-01-01

One of the most significant challenges in large-scale climate modeling, as well as in high-performance computing in other scientific fields, is that of effectively integrating many software models from multiple contributors. A software framework facilitates the integration task, both in the development and runtime stages of the simulation. Effective software frameworks reduce the programming burden for the investigators, freeing them to focus more on the science and less on the parallel communication implementation. while maintaining high performance across numerous supercomputer and workstation architectures. This document surveys numerous software frameworks for potential use in Earth science modeling. Several frameworks are evaluated in depth, including Parallel Object-Oriented Methods and Applications (POOMA), Cactus (from (he relativistic physics community), Overture, Goddard Earth Modeling System (GEMS), the National Center for Atmospheric Research Flux Coupler, and UCLA/UCB Distributed Data Broker (DDB). Frameworks evaluated in less detail include ROOT, Parallel Application Workspace (PAWS), and Advanced Large-Scale Integrated Computational Environment (ALICE). A host of other frameworks and related tools are referenced in this context. The frameworks are evaluated individually and also compared with each other.

Identifying the challenging factors in the transition from colleges of engineering to employment

NASA Astrophysics Data System (ADS)

Baytiyeh, Hoda; Naja, Mohamad

2012-03-01

The transition from university to a career in engineering is a challenging process. This study examined the perceptions of engineering graduates regarding the difficulties they encountered in their transition from the university to the workplace. Lebanese practising engineers (n=217), living around the world, were surveyed to identify their current employment situations and their attitudes toward their academic preparation. Factor analysis revealed three main challenges facing engineering graduates: communication; responsibility; self-confidence. Seventeen interviews were conducted to gather information on ways to facilitate this transition. Comments reflected the need for better collaboration between engineering schools and engineering firms. The results will provide insight for engineering colleges, faculty members and administrators into the challenges faced by graduates and their aspirations for a smoother transition into employment.

Marshall Team Recreates Goddard Rocket

NASA Technical Reports Server (NTRS)

2003-01-01

In honor of the Centernial of Flight celebration and commissioned by the American Institute of Aeronautics and Astronautics (AIAA), a team of engineers from Marshall Space Flight Center (MSFC) built a replica of the first liquid-fueled rocket. The original rocket, designed and built by rocket engineering pioneer Robert H. Goddard in 1926, opened the door to modern rocketry. Goddard's rocket reached an altitude of 41 feet while its flight lasted only 2.5 seconds. The Marshall design team's plan was to stay as close as possible to an authentic reconstruction of Goddard's rocket. The same propellants were used - liquid oxygen and gasoline - as available during Goddard's initial testing and firing. The team also tried to construct the replica using the original materials and design to the greatest extent possible. By purposely using less advanced techniques and materials than many that are available today, the team encountered numerous technical challenges in testing the functional hardware. There were no original blueprints or drawings, only photographs and notes. However, this faithful adherence to historical accuracy has also allowed the team to experience many of the same challenges Goddard faced 77 years ago, and more fully appreciate the genius of this extraordinary man. The replica will undergo ground tests at MSFC this summer.

Around Marshall

NASA Image and Video Library

2003-07-01

In honor of the Centernial of Flight celebration and commissioned by the American Institute of Aeronautics and Astronautics (AIAA), a team of engineers from Marshall Space Flight Center (MSFC) built a replica of the first liquid-fueled rocket. The original rocket, designed and built by rocket engineering pioneer Robert H. Goddard in 1926, opened the door to modern rocketry. Goddard's rocket reached an altitude of 41 feet while its flight lasted only 2.5 seconds. The Marshall design team's plan was to stay as close as possible to an authentic reconstruction of Goddard's rocket. The same propellants were used - liquid oxygen and gasoline - as available during Goddard's initial testing and firing. The team also tried to construct the replica using the original materials and design to the greatest extent possible. By purposely using less advanced techniques and materials than many that are available today, the team encountered numerous technical challenges in testing the functional hardware. There were no original blueprints or drawings, only photographs and notes. However, this faithful adherence to historical accuracy has also allowed the team to experience many of the same challenges Goddard faced 77 years ago, and more fully appreciate the genius of this extraordinary man. The replica will undergo ground tests at MSFC this summer.

Engineering nanomaterials-based biosensors for food safety detection.

PubMed

Lv, Man; Liu, Yang; Geng, Jinhui; Kou, Xiaohong; Xin, Zhihong; Yang, Dayong

2018-05-30

Food safety always remains a grand global challenge to human health, especially in developing countries. To solve food safety pertained problems, numerous strategies have been developed to detect biological and chemical contaminants in food. Among these approaches, nanomaterials-based biosensors provide opportunity to realize rapid, sensitive, efficient and portable detection, overcoming the restrictions and limitations of traditional methods such as complicated sample pretreatment, long detection time, and relying on expensive instruments and well-trained personnel. In this review article, we provide a cross-disciplinary perspective to review the progress of nanomaterials-based biosensors for the detection of food contaminants. The review article is organized by the category of food contaminants including pathogens/toxins, heavy metals, pesticides, veterinary drugs and illegal additives. In each category of food contaminant, the biosensing strategies are summarized including optical, colorimetric, fluorescent, electrochemical, and immune- biosensors; the relevant analytes, nanomaterials and biosensors are analyzed comprehensively. Future perspectives and challenges are also discussed briefly. We envision that our review could bridge the gap between the fields of food science and nanotechnology, providing implications for the scientists or engineers in both areas to collaborate and promote the development of nanomaterials-based biosensors for food safety detection. Copyright © 2018 Elsevier B.V. All rights reserved.

Effects of Numeric Representation of Women on Interest in Engineering as a Career

ERIC Educational Resources Information Center

Creamer, Elizabeth G.

2012-01-01

Little is known about how the presence of women influences undergraduates' experiences in engineering. This paper presents results from a mixed methods, multivariate, and multi-institutional study to determine the impact of the numeric representation of women on the intent to be employed in engineering following graduation. Results from the…

Humanlike Robots - Synthetically Mimicking Humans

NASA Technical Reports Server (NTRS)

Bar-Cohen, Yoseph

2012-01-01

Nature inspired many inventions and the field of technology that is based on the mimicking or inspiration of nature is widely known as Biomimetics and it is increasingly leading to many new capabilities. There are numerous examples of biomimetic successes including the copying of fins for swimming, and the inspiration of the insects and birds flight. More and more commercial implementations of biomimetics are appearing and behaving lifelike and applications are emerging that are important to our daily life. Making humanlike robots is the ultimate challenge to biomimetics and, for many years, it was considered science fiction, but such robots are becoming an engineering reality. Advances in producing such robot are allowing them to perform impressive functions and tasks. The development of such robots involves addressing many challenges and is raising concerns that are related to fear of their application implications and potential ethical issues. In this paper, the state-of-the-art of humanlike robots, potential applications and challenges will be reviewed.

Genetically engineered crops for biofuel production: regulatory perspectives.

PubMed

Lee, David; Chen, Alice; Nair, Ramesh

2008-01-01

There are numerous challenges in realizing the potential of biofuels that many policy makers have envisioned. The technical challenges in making the production of biofuels economical and on a scale to replace a significant fraction of transportation fuel have been well described, along with the potential environmental concerns. The use of biotechnology can potentially address many of these technical challenges and environmental concerns, but brings significant regulatory hurdles that have not been discussed extensively in the scientific community. This review will give an overview of the approaches being developed to produce transgenic biofuel feedstocks, particularly cellulosic ethanol, and the regulatory process in the United States that oversees the development and commercialization of new transgenic plants. We hope to illustrate that the level of regulation for transgenic organisms is not proportional to their potential risk to human health or the environment, and that revisions to the regulatory system in the U.S. currently under consideration are necessary to streamline the process.

Airplane numerical simulation for the rapid prototyping process

NASA Astrophysics Data System (ADS)

Roysdon, Paul F.

Airplane Numerical Simulation for the Rapid Prototyping Process is a comprehensive research investigation into the most up-to-date methods for airplane development and design. Uses of modern engineering software tools, like MatLab and Excel, are presented with examples of batch and optimization algorithms which combine the computing power of MatLab with robust aerodynamic tools like XFOIL and AVL. The resulting data is demonstrated in the development and use of a full non-linear six-degrees-of-freedom simulator. The applications for this numerical tool-box vary from un-manned aerial vehicles to first-order analysis of manned aircraft. A Blended-Wing-Body airplane is used for the analysis to demonstrate the flexibility of the code from classic wing-and-tail configurations to less common configurations like the blended-wing-body. This configuration has been shown to have superior aerodynamic performance -- in contrast to their classic wing-and-tube fuselage counterparts -- and have reduced sensitivity to aerodynamic flutter as well as potential for increased engine noise abatement. Of course without a classic tail elevator to damp the nose up pitching moment, and the vertical tail rudder to damp the yaw and possible rolling aerodynamics, the challenges in lateral roll and yaw stability, as well as pitching moment are not insignificant. This thesis work applies the tools necessary to perform the airplane development and optimization on a rapid basis, demonstrating the strength of this tool through examples and comparison of the results to similar airplane performance characteristics published in literature.

Rocket engine numerical simulation

NASA Astrophysics Data System (ADS)

Davidian, Ken

1993-12-01

The topics are presented in view graph form and include the following: a definition of the rocket engine numerical simulator (RENS); objectives; justification; approach; potential applications; potential users; RENS work flowchart; RENS prototype; and conclusions.

Rocket engine numerical simulation

NASA Technical Reports Server (NTRS)

Davidian, Ken

1993-01-01

The topics are presented in view graph form and include the following: a definition of the rocket engine numerical simulator (RENS); objectives; justification; approach; potential applications; potential users; RENS work flowchart; RENS prototype; and conclusions.

Self-Assembly and Crystallization of Hairy (f-Star) and DNA-Grafted Nanocubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knorowski, Christopher; Travesset, Alex

Nanoparticle superlattices are key to realizing many of the materials that will solve current technological challenges. Particularly important for their optical, mechanical or catalytic properties are superlattices of anisotropic (nonspherical) nanoparticles. The key challenge is how to program anisotropic nanoparticles to self-assemble into the relevant structures. In this Article, using numerical simulations, we show that “hairy” (f-star) or DNA grafted on nanocubes provides a general framework to direct the self-assembly into phases with crystalline, liquid crystalline, rotator, or noncrystalline phases with both long-range positional and orientational order. We discuss the relevance of these phases for engineering nanomaterials or micromaterials displayingmore » precise orientational order, realization of dry superlattices as well as for the field of programmed self-assembly of anisotropic nanoparticles in general.« less

Economic analysis of model validation for a challenge problem

DOE PAGES

Paez, Paul J.; Paez, Thomas L.; Hasselman, Timothy K.

2016-02-19

It is now commonplace for engineers to build mathematical models of the systems they are designing, building, or testing. And, it is nearly universally accepted that phenomenological models of physical systems must be validated prior to use for prediction in consequential scenarios. Yet, there are certain situations in which testing only or no testing and no modeling may be economically viable alternatives to modeling and its associated testing. This paper develops an economic framework within which benefit–cost can be evaluated for modeling and model validation relative to other options. The development is presented in terms of a challenge problem. Asmore » a result, we provide a numerical example that quantifies when modeling, calibration, and validation yield higher benefit–cost than a testing only or no modeling and no testing option.« less

Numerical Methods of Computational Electromagnetics for Complex Inhomogeneous Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cai, Wei

Understanding electromagnetic phenomena is the key in many scientific investigation and engineering designs such as solar cell designs, studying biological ion channels for diseases, and creating clean fusion energies, among other things. The objectives of the project are to develop high order numerical methods to simulate evanescent electromagnetic waves occurring in plasmon solar cells and biological ion-channels, where local field enhancement within random media in the former and long range electrostatic interactions in the latter are of major challenges for accurate and efficient numerical computations. We have accomplished these objectives by developing high order numerical methods for solving Maxwell equationsmore » such as high order finite element basis for discontinuous Galerkin methods, well-conditioned Nedelec edge element method, divergence free finite element basis for MHD, and fast integral equation methods for layered media. These methods can be used to model the complex local field enhancement in plasmon solar cells. On the other hand, to treat long range electrostatic interaction in ion channels, we have developed image charge based method for a hybrid model in combining atomistic electrostatics and continuum Poisson-Boltzmann electrostatics. Such a hybrid model will speed up the molecular dynamics simulation of transport in biological ion-channels.« less

Assessment of sub-grid scale dispersion closure with regularized deconvolution method in a particle-laden turbulent jet

NASA Astrophysics Data System (ADS)

Wang, Qing; Zhao, Xinyu; Ihme, Matthias

2017-11-01

Particle-laden turbulent flows are important in numerous industrial applications, such as spray combustion engines, solar energy collectors etc. It is of interests to study this type of flows numerically, especially using large-eddy simulations (LES). However, capturing the turbulence-particle interaction in LES remains challenging due to the insufficient representation of the effect of sub-grid scale (SGS) dispersion. In the present work, a closure technique for the SGS dispersion using regularized deconvolution method (RDM) is assessed. RDM was proposed as the closure for the SGS dispersion in a counterflow spray that is studied numerically using finite difference method on a structured mesh. A presumed form of LES filter is used in the simulations. In the present study, this technique has been extended to finite volume method with an unstructured mesh, where no presumption on the filter form is required. The method is applied to a series of particle-laden turbulent jets. Parametric analyses of the model performance are conducted for flows with different Stokes numbers and Reynolds numbers. The results from LES will be compared against experiments and direct numerical simulations (DNS).

A comparative analysis of numerical approaches to the mechanics of elastic sheets

NASA Astrophysics Data System (ADS)

Taylor, Michael; Davidovitch, Benny; Qiu, Zhanlong; Bertoldi, Katia

2015-06-01

Numerically simulating deformations in thin elastic sheets is a challenging problem in computational mechanics due to destabilizing compressive stresses that result in wrinkling. Determining the location, structure, and evolution of wrinkles in these problems has important implications in design and is an area of increasing interest in the fields of physics and engineering. In this work, several numerical approaches previously proposed to model equilibrium deformations in thin elastic sheets are compared. These include standard finite element-based static post-buckling approaches as well as a recently proposed method based on dynamic relaxation, which are applied to the problem of an annular sheet with opposed tractions where wrinkling is a key feature. Numerical solutions are compared to analytic predictions of the ground state, enabling a quantitative evaluation of the predictive power of the various methods. Results indicate that static finite element approaches produce local minima that are highly sensitive to initial imperfections, relying on a priori knowledge of the equilibrium wrinkling pattern to generate optimal results. In contrast, dynamic relaxation is much less sensitive to initial imperfections and can generate low-energy solutions for a wide variety of loading conditions without requiring knowledge of the equilibrium solution beforehand.

Metabolic engineering in chemolithoautotrophic hosts for the production of fuels and chemicals.

PubMed

Nybo, S Eric; Khan, Nymul E; Woolston, Benjamin M; Curtis, Wayne R

2015-07-01

The ability of autotrophic organisms to fix CO2 presents an opportunity to utilize this 'greenhouse gas' as an inexpensive substrate for biochemical production. Unlike conventional heterotrophic microorganisms that consume carbohydrates and amino acids, prokaryotic chemolithoautotrophs have evolved the capacity to utilize reduced chemical compounds to fix CO2 and drive metabolic processes. The use of chemolithoautotrophic hosts as production platforms has been renewed by the prospect of metabolically engineered commodity chemicals and fuels. Efforts such as the ARPA-E electrofuels program highlight both the potential and obstacles that chemolithoautotrophic biosynthetic platforms provide. This review surveys the numerous advances that have been made in chemolithoautotrophic metabolic engineering with a focus on hydrogen oxidizing bacteria such as the model chemolithoautotrophic organism (Ralstonia), the purple photosynthetic bacteria (Rhodobacter), and anaerobic acetogens. Two alternative strategies of microbial chassis development are considered: (1) introducing or enhancing autotrophic capabilities (carbon fixation, hydrogen utilization) in model heterotrophic organisms, or (2) improving tools for pathway engineering (transformation methods, promoters, vectors etc.) in native autotrophic organisms. Unique characteristics of autotrophic growth as they relate to bioreactor design and process development are also discussed in the context of challenges and opportunities for genetic manipulation of organisms as production platforms. Copyright © 2015 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

The Roles of Engineering Notebooks in Shaping Elementary Engineering Student Discourse and Practice

ERIC Educational Resources Information Center

Hertel, Jonathan D.; Cunningham, Christine M.; Kelly, Gregory J.

2017-01-01

Engineering design challenges offer important opportunities for students to learn science and engineering knowledge and practices. This study examines how students' engineering notebooks across four units of the curriculum "Engineering is Elementary" (EiE) support student work during design challenges. Through educational ethnography and…

Parallelization of Rocket Engine System Software (Press)

NASA Technical Reports Server (NTRS)

Cezzar, Ruknet

1996-01-01

The main goal is to assess parallelization requirements for the Rocket Engine Numeric Simulator (RENS) project which, aside from gathering information on liquid-propelled rocket engines and setting forth requirements, involve a large FORTRAN based package at NASA Lewis Research Center and TDK software developed by SUBR/UWF. The ultimate aim is to develop, test, integrate, and suitably deploy a family of software packages on various aspects and facets of rocket engines using liquid-propellants. At present, all project efforts by the funding agency, NASA Lewis Research Center, and the HBCU participants are disseminated over the internet using world wide web home pages. Considering obviously expensive methods of actual field trails, the benefits of software simulators are potentially enormous. When realized, these benefits will be analogous to those provided by numerous CAD/CAM packages and flight-training simulators. According to the overall task assignments, Hampton University's role is to collect all available software, place them in a common format, assess and evaluate, define interfaces, and provide integration. Most importantly, the HU's mission is to see to it that the real-time performance is assured. This involves source code translations, porting, and distribution. The porting will be done in two phases: First, place all software on Cray XMP platform using FORTRAN. After testing and evaluation on the Cray X-MP, the code will be translated to C + + and ported to the parallel nCUBE platform. At present, we are evaluating another option of distributed processing over local area networks using Sun NFS, Ethernet, TCP/IP. Considering the heterogeneous nature of the present software (e.g., first started as an expert system using LISP machines) which now involve FORTRAN code, the effort is expected to be quite challenging.

System Engineering on the Use for Ares I,V - the Simpler, the Better

NASA Technical Reports Server (NTRS)

Kelly, William; Greene, William D.; Greasley, Paul; Ackerman, Peter C.

2008-01-01

The Ares I and Ares V Vehicles will utilize the J-2X rocket engine developed for NASA by the Pratt & Whitney Rocketdyne Company. The J-2X is an improved higher power version of the original J-2 engine used during the Apollo program. With higher power and updated requirements for safety and performance, the J-2X becomes a new engine using state-of-the-art design methodology, materials and manufacturing processes. The implementation of Systems Engineering (SE) principles enables the rapid J-2X development program to remain aligned with the ARES I and V vehicle programs, Meeting the aggressive development schedule is a challenge. Coordinating the best expertise thai NASA and PWR have to offer requires effectively utilizing resources at multiple sites. This presents formidable communication challenges. SE allows honest and open discussions of issues and problems. This simple idea is often overlooked in large and complex SE programs. Regular and effective meetings linking SE objectives to component designs are used to voice differences of opinions with customer and contractor in attendance so that the best mutual decisions can be made on the shortest possible schedule. Regular technical interchange meetings on secure program wide computer networks and CM processes are effective,in the "Controlled Change" process that exemplifies good SE. Good communication is a key effective SE implementation. The System of Systems approach is the vision of the Orion program which facilitates the establishment of dynamic SE processes at all levels including the engine. SE enables requirements evolution by facilitating organizational and process agility. Flow down and distribution of requirements is controlled by Allocation Reports which breakdown numerical design objectives (weight, reliability, etc.) into quanta goals for each component area. Linked databases of design and verification requirements helps eliminate redundancy and potential mistakes inherent m separated systems. Another tool, the Architecture Design Description, is being used to control J-2X system architecture and effectively communicate configuration changes to those involved in the design process. But the proof is in successful program accomplishment. The SE is the methodology being used to meet the challenge of completing J-2X engine certification 2 years ahead of any engine program ever developed at PWR. The Ares I SE system of systems has delivered according to expectations thus far. All major design reviews (SRR. PDR, CDR) have been successfully conducted to satisfy overall program objectives using SE as the basis for accomplishment. The paper describes SE tools and techniques utilized to achieve this success.

Numerical Analysis of the Cavity Flow subjected to Passive Controls Techniques

NASA Astrophysics Data System (ADS)

Melih Guleren, Kursad; Turk, Seyfettin; Mirza Demircan, Osman; Demir, Oguzhan

2018-03-01

Open-source flow solvers are getting more and more popular for the analysis of challenging flow problems in aeronautical and mechanical engineering applications. They are offered under the GNU General Public License and can be run, examined, shared and modified according to user’s requirements. SU2 and OpenFOAM are the two most popular open-source solvers in Computational Fluid Dynamics (CFD) community. In the present study, some passive control methods on the high-speed cavity flows are numerically simulated using these open-source flow solvers along with one commercial flow solver called ANSYS/Fluent. The results are compared with the available experimental data. The solver SU2 are seen to predict satisfactory the mean streamline velocity but not turbulent kinetic energy and overall averaged sound pressure level (OASPL). Whereas OpenFOAM predicts all these parameters nearly as the same levels of ANSYS/Fluent.

High Fidelity Simulation of Transcritical Liquid Jet in Crossflow

NASA Astrophysics Data System (ADS)

Li, Xiaoyi; Soteriou, Marios

2017-11-01

Transcritical injection of liquid fuel occurs in many practical applications such as diesel, rocket and gas turbine engines. In these applications, the liquid fuel, with a supercritical pressure and a subcritical temperature, is introduced into an environment where both the pressure and temperature exceeds the critical point of the fuel. The convoluted physics of the transition from subcritical to supercritical conditions poses great challenges for both experimental and numerical investigations. In this work, numerical simulation of a binary system of a subcritical liquid injecting into a supercritical gaseous crossflow is performed. The spatially varying fluid thermodynamic and transport properties are evaluated using established cubic equation of state and extended corresponding state principles with established mixing rules. To efficiently account for the large spatial gradients in property variations, an adaptive mesh refinement technique is employed. The transcritical simulation results are compared with the predictions from the traditional subcritical jet atomization simulations.

Bubble dynamics, two-phase flow, and boiling heat transfer in a microgravity environment

NASA Technical Reports Server (NTRS)

Chung, Jacob N.

1994-01-01

The two-phase bubbly flow and boiling heat transfer in microgravity represents a substantial challenge to scientists and engineers and yet there is an urgent need to seek fundamental understanding in this area for future spacecraft design and space missions. At Washington State University, we have successfully designed, built and tested a 2.1 second drop tower with an innovation airbag deceleration system. Microgravity boiling experiments performed in our 0.6 second Drop Tower produced data flow visualizations that agree with published results and also provide some new understanding concerning flow boiling and microgravity bubble behavior. On the analytical and numerical work, the edge effects of finite divergent electrode plates on the forces experienced by bubbles were investigated. Boiling in a concentric cylinder microgravity and an electric field was numerically predicted. We also completed a feasibility study for microgravity boiling in an acoustic field.

MIDACO on MINLP space applications

NASA Astrophysics Data System (ADS)

Schlueter, Martin; Erb, Sven O.; Gerdts, Matthias; Kemble, Stephen; Rückmann, Jan-J.

2013-04-01

A numerical study on two challenging mixed-integer non-linear programming (MINLP) space applications and their optimization with MIDACO, a recently developed general purpose optimization software, is presented. These applications are the optimal control of the ascent of a multiple-stage space launch vehicle and the space mission trajectory design from Earth to Jupiter using multiple gravity assists. Additionally, an NLP aerospace application, the optimal control of an F8 aircraft manoeuvre, is discussed and solved. In order to enhance the optimization performance of MIDACO a hybridization technique, coupling MIDACO with an SQP algorithm, is presented for two of these three applications. The numerical results show, that the applications can be solved to their best known solution (or even new best solution) in a reasonable time by the considered approach. Since using the concept of MINLP is still a novelty in the field of (aero)space engineering, the demonstrated capabilities are seen as very promising.

Aeronautical Engineering: A Continuing Bibliography with Indexes (Supplement 218)

DTIC Science & Technology

1987-10-01

reviews the current situation and the history of development of cast turbine blades of Chinese aircraft engines for nearly three decades since 1956... aviation oils - Causes gas turbine engine p 592 N87-23577 MIDAIR COLLISIONS and consequences p 604 A87-40925 Aircraft Dynamic Response to Damaged and...numerical solution of the Navier-Stokes equations Numerical optimization design of transonic airfoils compressors of aircraft gas turbine engines p 553 A87

Numerical methods for engine-airframe integration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murthy, S.N.B.; Paynter, G.C.

1986-01-01

Various papers on numerical methods for engine-airframe integration are presented. The individual topics considered include: scientific computing environment for the 1980s, overview of prediction of complex turbulent flows, numerical solutions of the compressible Navier-Stokes equations, elements of computational engine/airframe integrations, computational requirements for efficient engine installation, application of CAE and CFD techniques to complete tactical missile design, CFD applications to engine/airframe integration, and application of a second-generation low-order panel methods to powerplant installation studies. Also addressed are: three-dimensional flow analysis of turboprop inlet and nacelle configurations, application of computational methods to the design of large turbofan engine nacelles, comparison ofmore » full potential and Euler solution algorithms for aeropropulsive flow field computations, subsonic/transonic, supersonic nozzle flows and nozzle integration, subsonic/transonic prediction capabilities for nozzle/afterbody configurations, three-dimensional viscous design methodology of supersonic inlet systems for advanced technology aircraft, and a user's technology assessment.« less

The two-stroke poppet valve engine. Part 2: Numerical investigations of intake and exhaust flow behaviour

NASA Astrophysics Data System (ADS)

Kamili Zahidi, M.; Razali Hanipah, M.

2017-10-01

A two-stroke poppet valve engine is developed to overcome the common problems in conventional two-stroke engine designs. However, replacing piston control port with poppet valve will resulted different flow behaviour. This paper presents the model and simulation result of three-dimensional (3D) port flow investigation of a two-stroke poppet valve engine. The objective of the investigation is to conduct a numerical investigation on port flow performance of two-stroke poppet valve engine and compare the results obtained from the experimental investigation. The model is to be used for the future numerical study of the engine. The volume flow rate results have been compared with the results obtained experimentally as presented in first part of this paper. The model has shown good agreement in terms of the flow rate at initial and final valve lifts but reduced by about 50% during half-lift region.

Functional tissue engineering of tendon: Establishing biological success criteria for improving tendon repair.

PubMed

Breidenbach, Andrew P; Gilday, Steven D; Lalley, Andrea L; Dyment, Nathaniel A; Gooch, Cynthia; Shearn, Jason T; Butler, David L

2014-06-27

Improving tendon repair using Functional Tissue Engineering (FTE) principles has been the focus of our laboratory over the last decade. Although our primary goals were initially focused only on mechanical outcomes, we are now carefully assessing the biological properties of our tissue-engineered tendon repairs so as to link biological influences with mechanics. However, given the complexities of tendon development and healing, it remains challenging to determine which aspects of tendon biology are the most important to focus on in the context of tissue engineering. To address this problem, we have formalized a strategy to identify, prioritize, and evaluate potential biological success criteria for tendon repair. We have defined numerous biological properties of normal tendon relative to cellular phenotype, extracellular matrix and tissue ultra-structure that we would like to reproduce in our tissue-engineered repairs and prioritized these biological criteria by examining their relative importance during both normal development and natural tendon healing. Here, we propose three specific biological criteria which we believe are essential for normal tendon function: (1) scleraxis-expressing cells; (2) well-organized and axially-aligned collagen fibrils having bimodal diameter distribution; and (3) a specialized tendon-to-bone insertion site. Moving forward, these biological success criteria will be used in conjunction with our already established mechanical success criteria to evaluate the effectiveness of our tissue-engineered tendon repairs. © 2013 Published by Elsevier Ltd.

Microcomputed tomography characterization of neovascularization in bone tissue engineering applications.

PubMed

Young, Simon; Kretlow, James D; Nguyen, Charles; Bashoura, Alex G; Baggett, L Scott; Jansen, John A; Wong, Mark; Mikos, Antonios G

2008-09-01

Vasculogenesis and angiogenesis have been studied for decades using numerous in vitro and in vivo systems, fulfilling the need to elucidate the mechanisms involved in these processes and to test potential therapeutic agents that inhibit or promote neovascularization. Bone tissue engineering in particular has benefited from the application of proangiogenic strategies, considering the need for an adequate vascular supply during healing and the challenges associated with the vascularization of scaffolds implanted in vivo. Conventional methods of assessing the in vivo angiogenic response to tissue-engineered constructs tend to rely on a two-dimensional assessment of microvessel density within representative histological sections without elaboration of the true vascular tree. The introduction of microcomputed tomography (micro-CT) has recently allowed investigators to obtain a diverse range of high-resolution, three-dimensional characterization of structures, including renal, coronary, and hepatic vascular networks, as well as bone formation within healing defects. To date, few studies have utilized micro-CT to study the vascular response to an implanted tissue engineering scaffold. In this paper, conventional in vitro and in vivo models for studying angiogenesis will be discussed, followed by recent developments in the use of micro-CT for vessel imaging in bone tissue engineering research. A new study demonstrating the potential of contrast-enhanced micro-CT for the evaluation of in vivo neovascularization in bony defects is described, which offers significant potential in the evaluation of bone tissue engineering constructs.

Collaborative engineering and design management for the Hobby-Eberly Telescope tracker upgrade

NASA Astrophysics Data System (ADS)

Mollison, Nicholas T.; Hayes, Richard J.; Good, John M.; Booth, John A.; Savage, Richard D.; Jackson, John R.; Rafal, Marc D.; Beno, Joseph H.

2010-07-01

The engineering and design of systems as complex as the Hobby-Eberly Telescope's* new tracker require that multiple tasks be executed in parallel and overlapping efforts. When the design of individual subsystems is distributed among multiple organizations, teams, and individuals, challenges can arise with respect to managing design productivity and coordinating successful collaborative exchanges. This paper focuses on design management issues and current practices for the tracker design portion of the Hobby-Eberly Telescope Wide Field Upgrade project. The scope of the tracker upgrade requires engineering contributions and input from numerous fields including optics, instrumentation, electromechanics, software controls engineering, and site-operations. Successful system-level integration of tracker subsystems and interfaces is critical to the telescope's ultimate performance in astronomical observation. Software and process controls for design information and workflow management have been implemented to assist the collaborative transfer of tracker design data. The tracker system architecture and selection of subsystem interfaces has also proven to be a determining factor in design task formulation and team communication needs. Interface controls and requirements change controls will be discussed, and critical team interactions are recounted (a group-participation Failure Modes and Effects Analysis [FMEA] is one of special interest). This paper will be of interest to engineers, designers, and managers engaging in multi-disciplinary and parallel engineering projects that require coordination among multiple individuals, teams, and organizations.

[Advances of consolidated bioprocessing based on recombinant strategy].

PubMed

Zheng, Zongbao; Zhao, Meina; Chen, Tao; Zhao, Xueming

2013-10-01

Lignocellulosic biomass represents an abundant, low-cost and renewable source of potentially fermentable sugars. It is acandidate besides petroleum as feedstock for fuel and chemical production. Recent researches on utilizing lignocellulosicsas feedstock boost development of numerous-promising processes for a variety of fuels and chemicals, such as biodiesel, biohydrogen and ethanol. However, high cost in depolymerization is a primary obstacle preventing the use of lignocellulosic biomass as feedstock. Consolidated bioprocessing (CBP), refers to the bioprocess without any exogenous cellulolyotic enzymes added, converting the lignocellulosic material into biochemicals directly, which could potentially avoid the cost of the dedicated enzyme generation step by incorporating enzyme-generating, biomass-degrading and bioproduct-producing capabilities into a single organism through genetic engineering. There are two CBP strategies, native strategy and recombinant strategy. We mainly introduce the recombinant strategy, including its principle, the two responding styles, the contributions of synthetic biology and metabolic engineering and the future challenges.

Invertebrate biomechanics.

PubMed

Patek, S N; Summers, A P

2017-05-22

Invertebrate biomechanics focuses on mechanical analyses of non-vertebrate animals, which at root is no different in aim and technique from vertebrate biomechanics, or for that matter the biomechanics of plants and fungi. But invertebrates are special - they are fabulously diverse in form, habitat, and ecology and manage this without the use of hard, internal skeletons. They are also numerous and, in many cases, tractable in an experimental and field setting. In this Primer, we will probe three axes of invertebrate diversity: worms (Phylum Annelida), spiders (Class Arachnida) and insects (Class Insecta); three habitats: subterranean, terrestrial and airborne; and three integrations with other fields: ecology, engineering and evolution. Our goal is to capture the field of invertebrate biomechanics, which has blossomed from having a primary focus on discoveries at the interface of physics and biology to being inextricably linked with integrative challenges that span biology, physics, mathematics and engineering. Copyright © 2017 Elsevier Ltd. All rights reserved.

Computational approaches for rational design of proteins with novel functionalities

PubMed Central

Tiwari, Manish Kumar; Singh, Ranjitha; Singh, Raushan Kumar; Kim, In-Won; Lee, Jung-Kul

2012-01-01

Proteins are the most multifaceted macromolecules in living systems and have various important functions, including structural, catalytic, sensory, and regulatory functions. Rational design of enzymes is a great challenge to our understanding of protein structure and physical chemistry and has numerous potential applications. Protein design algorithms have been applied to design or engineer proteins that fold, fold faster, catalyze, catalyze faster, signal, and adopt preferred conformational states. The field of de novo protein design, although only a few decades old, is beginning to produce exciting results. Developments in this field are already having a significant impact on biotechnology and chemical biology. The application of powerful computational methods for functional protein designing has recently succeeded at engineering target activities. Here, we review recently reported de novo functional proteins that were developed using various protein design approaches, including rational design, computational optimization, and selection from combinatorial libraries, highlighting recent advances and successes. PMID:24688643

Aircraft Engine Systems

NASA Technical Reports Server (NTRS)

Veres, Joseph P.

2003-01-01

The objective is to develop the capability to numerically model the performance of gas turbine engines used for aircraft propulsion. This capability will provide turbine engine designers with a means of accurately predicting the performance of new engines in a system environment prior to building and testing. The 'numerical test cell' developed under this project will reduce the number of component and engine tests required during development. As a result, the project will help to reduce the design cycle time and cost of gas turbine engines. This capability will be distributed to U.S. turbine engine manufacturers and air framers. This project focuses on goals of maintaining U.S. superiority in commercial gas turbine engine development for the aeronautics industry.

Progress and challenges in improving the nutritional quality of rice (Oryza sativa L.).

PubMed

Birla, Deep Shikha; Malik, Kapil; Sainger, Manish; Chaudhary, Darshna; Jaiwal, Ranjana; Jaiwal, Pawan K

2017-07-24

Rice is a staple food for more than 3 billion people in more than 100 countries of the world but ironically it is deficient in many bioavailable vitamins, minerals, essential amino- and fatty-acids and phytochemicals that prevent chronic diseases like type 2 diabetes, heart disease, cancers, and obesity. To enhance the nutritional and other quality aspects of rice, a better understanding of the regulation of the processes involved in the synthesis, uptake, transport, and metabolism of macro-(starch, seed storage protein and lipid) and micronutrients (vitamins, minerals and phytochemicals) is required. With the publication of high quality genomic sequence of rice, significant progress has been made in identification, isolation, and characterization of novel genes and their regulation for the nutritional and quality enhancement of rice. During the last decade, numerous efforts have been made to refine the nutritional and other quality traits either by using the traditional breeding with high through put technologies such as marker assisted selection and breeding, or by adopting the transgenic approach. A significant improvement in vitamins (A, folate, and E), mineral (iron), essential amino acid (lysine), and flavonoids levels has been achieved in the edible part of rice, i.e., endosperm (biofortification) to meet the daily dietary allowance. However, studies on bioavailability and allergenicity on biofortified rice are still required. Despite the numerous efforts, the commercialization of biofortified rice has not yet been achieved. The present review summarizes the progress and challenges of genetic engineering and/or metabolic engineering technologies to improve rice grain quality, and presents the future prospects in developing nutrient dense rice to save the everincreasing population, that depends solely on rice as the staple food, from widespread nutritional deficiencies.

Towards an Automated Full-Turbofan Engine Numerical Simulation

NASA Technical Reports Server (NTRS)

Reed, John A.; Turner, Mark G.; Norris, Andrew; Veres, Joseph P.

2003-01-01

The objective of this study was to demonstrate the high-fidelity numerical simulation of a modern high-bypass turbofan engine. The simulation utilizes the Numerical Propulsion System Simulation (NPSS) thermodynamic cycle modeling system coupled to a high-fidelity full-engine model represented by a set of coupled three-dimensional computational fluid dynamic (CFD) component models. Boundary conditions from the balanced, steady-state cycle model are used to define component boundary conditions in the full-engine model. Operating characteristics of the three-dimensional component models are integrated into the cycle model via partial performance maps generated automatically from the CFD flow solutions using one-dimensional meanline turbomachinery programs. This paper reports on the progress made towards the full-engine simulation of the GE90-94B engine, highlighting the generation of the high-pressure compressor partial performance map. The ongoing work will provide a system to evaluate the steady and unsteady aerodynamic and mechanical interactions between engine components at design and off-design operating conditions.

The Need and Challenges for Distributed Engine Control

NASA Technical Reports Server (NTRS)

Culley, Dennis E.

2013-01-01

The presentation describes the challenges facing the turbine engine control system. These challenges are primarily driven by a dependence on commercial electronics and an increasingly severe environment on board the turbine engine. The need for distributed control is driven by the need to overcome these system constraints and develop a new growth path for control technology and, as a result, improved turbine engine performance.

Spray combustion experiments and numerical predictions

NASA Technical Reports Server (NTRS)

Mularz, Edward J.; Bulzan, Daniel L.; Chen, Kuo-Huey

1993-01-01

The next generation of commercial aircraft will include turbofan engines with performance significantly better than those in the current fleet. Control of particulate and gaseous emissions will also be an integral part of the engine design criteria. These performance and emission requirements present a technical challenge for the combustor: control of the fuel and air mixing and control of the local stoichiometry will have to be maintained much more rigorously than with combustors in current production. A better understanding of the flow physics of liquid fuel spray combustion is necessary. This paper describes recent experiments on spray combustion where detailed measurements of the spray characteristics were made, including local drop-size distributions and velocities. Also, an advanced combustor CFD code has been under development and predictions from this code are compared with experimental results. Studies such as these will provide information to the advanced combustor designer on fuel spray quality and mixing effectiveness. Validation of new fast, robust, and efficient CFD codes will also enable the combustor designer to use them as additional design tools for optimization of combustor concepts for the next generation of aircraft engines.

Computational study of culture conditions and nutrient supply in a hollow membrane sheet bioreactor for large-scale bone tissue engineering.

PubMed

Khademi, Ramin; Mohebbi-Kalhori, Davod; Hadjizadeh, Afra

2014-03-01

Successful bone tissue culture in a large implant is still a challenge. We have previously developed a porous hollow membrane sheet (HMSh) for tissue engineering applications (Afra Hadjizadeh and Davod Mohebbi-Kalhori, J Biomed. Mater. Res. Part A [2]). This study aims to investigate culture conditions and nutrient supply in a bioreactor made of HMSh. For this purpose, hydrodynamic and mass transport behavior in the newly proposed hollow membrane sheet bioreactor including a lumen region and porous membrane (scaffold) for supporting and feeding cells with a grooved section for accommodating gel-cell matrix was numerically studied. A finite element method was used for solving the governing equations in both homogenous and porous media. Furthermore, the cell resistance and waste production have been included in a 3D mathematical model. The influences of different bioreactor design parameters and the scaffold properties which determine the HMSh bioreactor performance and various operating conditions were discussed in detail. The obtained results illustrated that the novel scaffold can be employed in the large-scale applications in bone tissue engineering.

Numerical simulations of icing in turbomachinery

NASA Astrophysics Data System (ADS)

Das, Kaushik

Safety concerns over aircraft icing and the high experimental cost of testing have spurred global interest in numerical simulations of the ice accretion process. Extensive experimental and computational studies have been carried out to understand the icing on external surfaces. No parallel initiatives were reported for icing on engine components. However, the supercooled water droplets in moist atmosphere that are ingested into the engine can impinge on the component surfaces and freeze to form ice deposits. Ice accretion could block the engine passage causing reduced airflow. It raises safety and performance concerns such as mechanical damage from ice shedding as well as slow acceleration leading to compressor stall. The current research aims at developing a computational methodology for prediction of icing phenomena on turbofan compression system. Numerical simulation of ice accretion in aircraft engines is highly challenging because of the complex 3-D unsteady turbomachinery flow and the effects of rotation on droplet trajectories. The aim of the present research focuses on (i) Developing a computational methodology for ice accretion in rotating turbomachinery components; (ii) Investigate the effect of inter-phase heat exchange; (iii) Characterize droplet impingement pattern and ice accretion at different operating conditions. The simulations of droplet trajectories are based on a Eulerian-Lagrangian approach for the continuous and discrete phases. The governing equations are solved in the rotating blade frame of reference. The flow field is computed by solving the 3-D solution of the compressible Reynolds Averaged Navier Stokes (RANS) equations. One-way interaction models simulate the effects of aerodynamic forces and the energy exchange between the flow and the droplets. The methodology is implemented in the cool, TURBODROP and applied to the flow field and droplet trajectories in NASA Roto-67r and NASA-GE E3 booster rotor. The results highlight the variation of impingement location and temperature with droplet size. It also illustrates the effect of rotor speed on droplet temperature rise. The computed droplet impingement statistics and flow properties are used to calculate ice shapes. It was found that the mass of accreted ice and maximum thickness is highly sensitive to rotor speed and radial location.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Second SIAM Conference on Computational Science and Engineering was held in San Diego from February 10-12, 2003. Total conference attendance was 553. This is a 23% increase in attendance over the first conference. The focus of this conference was to draw attention to the tremendous range of major computational efforts on large problems in science and engineering, to promote the interdisciplinary culture required to meet these large-scale challenges, and to encourage the training of the next generation of computational scientists. Computational Science & Engineering (CS&E) is now widely accepted, along with theory and experiment, as a crucial third modemore » of scientific investigation and engineering design. Aerospace, automotive, biological, chemical, semiconductor, and other industrial sectors now rely on simulation for technical decision support. For federal agencies also, CS&E has become an essential support for decisions on resources, transportation, and defense. CS&E is, by nature, interdisciplinary. It grows out of physical applications and it depends on computer architecture, but at its heart are powerful numerical algorithms and sophisticated computer science techniques. From an applied mathematics perspective, much of CS&E has involved analysis, but the future surely includes optimization and design, especially in the presence of uncertainty. Another mathematical frontier is the assimilation of very large data sets through such techniques as adaptive multi-resolution, automated feature search, and low-dimensional parameterization. The themes of the 2003 conference included, but were not limited to: Advanced Discretization Methods; Computational Biology and Bioinformatics; Computational Chemistry and Chemical Engineering; Computational Earth and Atmospheric Sciences; Computational Electromagnetics; Computational Fluid Dynamics; Computational Medicine and Bioengineering; Computational Physics and Astrophysics; Computational Solid Mechanics and Materials; CS&E Education; Meshing and Adaptivity; Multiscale and Multiphysics Problems; Numerical Algorithms for CS&E; Discrete and Combinatorial Algorithms for CS&E; Inverse Problems; Optimal Design, Optimal Control, and Inverse Problems; Parallel and Distributed Computing; Problem-Solving Environments; Software and Wddleware Systems; Uncertainty Estimation and Sensitivity Analysis; and Visualization and Computer Graphics.« less

Engineering Background: Modern Formats and Challenges of Conceptual Engineering

NASA Astrophysics Data System (ADS)

Khamidullina, A. F.; Kuzmina, M. A.; Khusnutdinova, E. M.; Konakhina, I. A.

2017-09-01

This paper describes the analysis of problems and development perspectives of engineering education in our and other countries. Special attention is given to modern formats of education that motivate creative efforts of engineers-to-be as well as issues of conceptual engineering taking the challenges of modernity into account.

HydroViz: A web-based hydrologic observatory for enhancing hydrology and earth-science education

NASA Astrophysics Data System (ADS)

Habib, E. H.; Ma, Y.; Williams, D.

2010-12-01

The main goal of this study is to develop a virtual hydrologic observatory (HydroViz) that integrates hydrologic field observations with numerical simulations by taking advantage of advances in hydrologic field & remote sensing data, computer modeling, scientific visualization, and web resources and internet accessibility. The HydroViz system is a web-based teaching tool that can run on any web browsers. It leverages the strength of Google Earth to provide authentic and hands-on activities to improve learning. Evaluation of the HydroViz was performed in three engineering courses (a senior level course and two Introductory courses at two different universities). Evaluation results indicate that HydroViz provides an improvement over existing engineering hydrology curriculum. HydroViz was effective in facilitating students’ learning and understanding of hydrologic concepts & increasing related skills. HydroViz was much more effective for students in engineering hydrology classes rather than at the freshmen introduction to civil engineering class. We found that HydroViz has great potential for freshmen audience. Even though HydroViz was challenging to some freshmen, most of them still learned the key concepts and the tool increased the enthusiasm for half of the freshmen. The evaluation provided suggestions to create a simplified version of HydroViz for freshmen-level courses students. It identified concepts and tasks that might be too challenging or irrelevant to the freshmen and areas where we could provide more guidance in the tool. After the first round of evaluation, the development team has made significant improvements to HydroViz, which would further improve its effectiveness for next round of class applications which is planned for the Fall of 2010 to take place in 5 classes at 4 different institutions.

Research in applied mathematics, numerical analysis, and computer science

NASA Technical Reports Server (NTRS)

1984-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering (ICASE) in applied mathematics, numerical analysis, and computer science is summarized and abstracts of published reports are presented. The major categories of the ICASE research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software, especially vector and parallel computers.

High-Fidelity Simulation in Biomedical and Aerospace Engineering

NASA Technical Reports Server (NTRS)

Kwak, Dochan

2005-01-01

Contents include the following: Introduction / Background. Modeling and Simulation Challenges in Aerospace Engineering. Modeling and Simulation Challenges in Biomedical Engineering. Digital Astronaut. Project Columbia. Summary and Discussion.

Numerical Prediction of the Influence of Thrust Reverser on Aeroengine's Aerodynamic Stability

NASA Astrophysics Data System (ADS)

Zhiqiang, Wang; Xigang, Shen; Jun, Hu; Xiang, Gao; Liping, Liu

2017-11-01

A numerical method was developed to predict the aerodynamic stability of a high bypass ratio turbofan engine, at the landing stage of a large transport aircraft, when the thrust reverser was deployed. 3D CFD simulation and 2D aeroengine aerodynamic stability analysis code were performed in this work, the former is to achieve distortion coefficient for the analysis of engine stability. The 3D CFD simulation was divided into two steps, the single engine calculation and the integrated aircraft and engine calculation. Results of the CFD simulation show that with the decreasing of relative wind Mach number, the engine inlet will suffer more severe flow distortion. The total pressure and total temperature distortion coefficients at the inlet of the engines were obtained from the results of the numerical simulation. Then an aeroengine aerodynamic stability analysis program was used to quantitatively analyze the aerodynamic stability of the high bypass ratio turbofan engine. The results of the stability analysis show that the engine can work stably, when the reverser flow is re-ingested. But the anti-distortion ability of the booster is weaker than that of the fan and high pressure compressor. It is a weak link of engine stability.

Influences of system uncertainties on the numerical transfer path analysis of engine systems

NASA Astrophysics Data System (ADS)

Acri, A.; Nijman, E.; Acri, A.; Offner, G.

2017-10-01

Practical mechanical systems operate with some degree of uncertainty. In numerical models uncertainties can result from poorly known or variable parameters, from geometrical approximation, from discretization or numerical errors, from uncertain inputs or from rapidly changing forcing that can be best described in a stochastic framework. Recently, random matrix theory was introduced to take parameter uncertainties into account in numerical modeling problems. In particular in this paper, Wishart random matrix theory is applied on a multi-body dynamic system to generate random variations of the properties of system components. Multi-body dynamics is a powerful numerical tool largely implemented during the design of new engines. In this paper the influence of model parameter variability on the results obtained from the multi-body simulation of engine dynamics is investigated. The aim is to define a methodology to properly assess and rank system sources when dealing with uncertainties. Particular attention is paid to the influence of these uncertainties on the analysis and the assessment of the different engine vibration sources. Examples of the effects of different levels of uncertainties are illustrated by means of examples using a representative numerical powertrain model. A numerical transfer path analysis, based on system dynamic substructuring, is used to derive and assess the internal engine vibration sources. The results obtained from this analysis are used to derive correlations between parameter uncertainties and statistical distribution of results. The derived statistical information can be used to advance the knowledge of the multi-body analysis and the assessment of system sources when uncertainties in model parameters are considered.

Test Driven Development of Scientific Models

NASA Technical Reports Server (NTRS)

Clune, Thomas L.

2014-01-01

Test-Driven Development (TDD), a software development process that promises many advantages for developer productivity and software reliability, has become widely accepted among professional software engineers. As the name suggests, TDD practitioners alternate between writing short automated tests and producing code that passes those tests. Although this overly simplified description will undoubtedly sound prohibitively burdensome to many uninitiated developers, the advent of powerful unit-testing frameworks greatly reduces the effort required to produce and routinely execute suites of tests. By testimony, many developers find TDD to be addicting after only a few days of exposure, and find it unthinkable to return to previous practices.After a brief overview of the TDD process and my experience in applying the methodology for development activities at Goddard, I will delve more deeply into some of the challenges that are posed by numerical and scientific software as well as tools and implementation approaches that should address those challenges.

A Geology Sampling System for Small Bodies

NASA Technical Reports Server (NTRS)

Hood, A. D.; Naids, A. J.; Graff, T.; Abell, P.

2015-01-01

Human exploration of Small Bodies is being investigated as a precursor to a Mars surface mission. Asteroids, comets, dwarf planets, and the moons of Mars all fall into this Small Bodies category and some are being discussed as potential mission tar-gets. Obtaining geological samples for return to Earth will be a major objective for any mission to a Small Body. Currently the knowledge base for geology sampling in microgravity is in its infancy. Furthermore, humans interacting with non-engineered surfaces in a microgravity environment poses unique challenges. In preparation for such missions, a team at the National Aeronautics and Space Administration (NASA) John-son Space Center (JSC) has been working to gain experience on how to safely obtain numerous sample types in such an environment. This abstract briefly summarizes the type of samples the science community is interested in, discusses an integrated geology sampling solution, and highlights some of the unique challenges associated with this type of exploration.

Nonequilibrium Tuning of the Thermal Casimir Effect.

PubMed

Dean, David S; Lu, Bing-Sui; Maggs, A C; Podgornik, Rudolf

2016-06-17

In net-neutral systems correlations between charge fluctuations generate strong attractive thermal Casimir forces and engineering these forces to optimize nanodevice performance is an important challenge. We show how the normal and lateral thermal Casimir forces between two plates containing Brownian charges can be modulated by decorrelating the system through the application of an electric field, which generates a nonequilibrium steady state with a constant current in one or both plates, reducing the ensuing fluctuation-generated normal force while at the same time generating a lateral drag force. This hypothesis is confirmed by detailed numerical simulations as well as an analytical approach based on stochastic density functional theory.

Beyond the Renderer: Software Architecture for Parallel Graphics and Visualization

NASA Technical Reports Server (NTRS)

Crockett, Thomas W.

1996-01-01

As numerous implementations have demonstrated, software-based parallel rendering is an effective way to obtain the needed computational power for a variety of challenging applications in computer graphics and scientific visualization. To fully realize their potential, however, parallel renderers need to be integrated into a complete environment for generating, manipulating, and delivering visual data. We examine the structure and components of such an environment, including the programming and user interfaces, rendering engines, and image delivery systems. We consider some of the constraints imposed by real-world applications and discuss the problems and issues involved in bringing parallel rendering out of the lab and into production.

Injection Laser Structure Design.

DTIC Science & Technology

1985-01-30

A. Linz and J. Butler Electrical Engineering Department Southern Methodist University Dallas, Texas 75275 Abstract A numerical method and the... NUMERICAL AND EFFECTIVE-INDEX METHODS FOR A CLASS OF DIELECTRIC WAVEGUIDES* H-.2 A. Linz and J.K. Butler Electrical Engineering Department Southern...University, Dallas, TX, where he is now Professor of Electrical methd w usd i notpraticl fr etensve odeingdue Engineering . His primary research areas are solid

Reverse-engineering of gene networks for regulating early blood development from single-cell measurements.

PubMed

Wei, Jiangyong; Hu, Xiaohua; Zou, Xiufen; Tian, Tianhai

2017-12-28

Recent advances in omics technologies have raised great opportunities to study large-scale regulatory networks inside the cell. In addition, single-cell experiments have measured the gene and protein activities in a large number of cells under the same experimental conditions. However, a significant challenge in computational biology and bioinformatics is how to derive quantitative information from the single-cell observations and how to develop sophisticated mathematical models to describe the dynamic properties of regulatory networks using the derived quantitative information. This work designs an integrated approach to reverse-engineer gene networks for regulating early blood development based on singel-cell experimental observations. The wanderlust algorithm is initially used to develop the pseudo-trajectory for the activities of a number of genes. Since the gene expression data in the developed pseudo-trajectory show large fluctuations, we then use Gaussian process regression methods to smooth the gene express data in order to obtain pseudo-trajectories with much less fluctuations. The proposed integrated framework consists of both bioinformatics algorithms to reconstruct the regulatory network and mathematical models using differential equations to describe the dynamics of gene expression. The developed approach is applied to study the network regulating early blood cell development. A graphic model is constructed for a regulatory network with forty genes and a dynamic model using differential equations is developed for a network of nine genes. Numerical results suggests that the proposed model is able to match experimental data very well. We also examine the networks with more regulatory relations and numerical results show that more regulations may exist. We test the possibility of auto-regulation but numerical simulations do not support the positive auto-regulation. In addition, robustness is used as an importantly additional criterion to select candidate networks. The research results in this work shows that the developed approach is an efficient and effective method to reverse-engineer gene networks using single-cell experimental observations.

First-Year Students' Attitudes towards the Grand Challenges and Nanotechnology

ERIC Educational Resources Information Center

Lakin, Joni M.; Han, Yi; Davis, Edward

2016-01-01

The "Grand Challenges" for Engineering are an effort to portray engineering as a field that has profound impacts on society. This study explores the level of interest first-year engineering students had in various "Grand Challenges" and in nanotechnology topics. We administered a survey to a large sample of students enrolled in…

Academic Preparedness as a Predictor of Achievement in an Engineering Design Challenge

ERIC Educational Resources Information Center

Mentzer, Nathan; Becker, Kurt

2010-01-01

The purpose of this study was to determine if a student's academic success, measured by grade point average (GPA) in mathematics, science, and communication courses, is correlated with student change in achievement during an engineering design challenge. Engineering design challenges have been implemented and researched in K-16 environments where…

Grand challenges for biological engineering

PubMed Central

Yoon, Jeong-Yeol; Riley, Mark R

2009-01-01

Biological engineering will play a significant role in solving many of the world's problems in medicine, agriculture, and the environment. Recently the U.S. National Academy of Engineering (NAE) released a document "Grand Challenges in Engineering," covering broad realms of human concern from sustainability, health, vulnerability and the joy of living. Biological engineers, having tools and techniques at the interface between living and non-living entities, will play a prominent role in forging a better future. The 2010 Institute of Biological Engineering (IBE) conference in Cambridge, MA, USA will address, in part, the roles of biological engineering in solving the challenges presented by the NAE. This letter presents a brief outline of how biological engineers are working to solve these large scale and integrated problems of our society. PMID:19772647

A numerical investigation on the influence of engine shape and mixing processes on wave engine performance

NASA Astrophysics Data System (ADS)

Erickson, Robert R.

Wave engines are a class of unsteady, air-breathing propulsion devices that use an intermittent combustion process to generate thrust. The inherently simple mechanical design of the wave engine allows for a relatively low cost per unit propulsion system, yet unsatisfactory overall performance has severely limited the development of commercially successful wave engines. The primary objective of this investigation was to develop a more detailed physical understanding of the influence of gas dynamic nonlinearities, unsteady combustion processes, and engine shape on overall wave engine performance. Within this study, several numerical models were developed and applied to wave engines and related applications. The first portion of this investigation examined the influence of duct shape on driven oscillations in acoustic compression devices, which represent a simplified physical system closely related in several ways to the wave engine. A numerical model based on an application of the Galerkin method was developed to simulate large amplitude, one-dimensional acoustic waves driven in closed ducts. Results from this portion of the investigation showed that gas-dynamic nonlinearities significantly influence the properties of driven oscillations by transferring acoustic energy from the fundamental driven mode into higher harmonic modes. The second portion of this investigation presented and analyzed results from a numerical model of wave engine dynamics based on the quasi one-dimensional conservation equations in addition to separate sub-models for mixing and heat release. This model was then used to perform parametric studies of the characteristics of mixing and engine shape. The objectives of these studies were to determine the influence of mixing characteristics and engine shape on overall wave engine performance and to develop insight into the physical processes controlling overall performance trends. Results from this model showed that wave engine performance was strongly dependent on the coupling between the unsteady heat release that drives oscillations in the engine and the characteristics that determine the acoustic properties of the engine such as engine shape and mean property gradients. Simulation results showed that average thrust generation decreased dramatically when the natural acoustic mode frequencies of the engine and the frequency content of the unsteady heat release were not aligned.

Biological approaches for addressing the grand challenge of providing access to clean drinking water.

PubMed

Riley, Mark R; Gerba, Charles P; Elimelech, Menachem

2011-03-31

The U.S. National Academy of Engineering (NAE) recently published a document presenting "Grand Challenges for Engineering". This list was proposed by leading engineers and scientists from around the world at the request of the U.S. National Science Foundation (NSF). Fourteen topics were selected for these grand challenges, and at least seven can be addressed using the tools and methods of biological engineering. Here we describe how biological engineers can address the challenge of providing access to clean drinking water. This issue must be addressed in part by removing or inactivating microbial and chemical contaminants in order to properly deliver water safe for human consumption. Despite many advances in technologies this challenge is expanding due to increased pressure on fresh water supplies and to new opportunities for growth of potentially pathogenic organisms.

Biological approaches for addressing the grand challenge of providing access to clean drinking water

PubMed Central

2011-01-01

The U.S. National Academy of Engineering (NAE) recently published a document presenting "Grand Challenges for Engineering". This list was proposed by leading engineers and scientists from around the world at the request of the U.S. National Science Foundation (NSF). Fourteen topics were selected for these grand challenges, and at least seven can be addressed using the tools and methods of biological engineering. Here we describe how biological engineers can address the challenge of providing access to clean drinking water. This issue must be addressed in part by removing or inactivating microbial and chemical contaminants in order to properly deliver water safe for human consumption. Despite many advances in technologies this challenge is expanding due to increased pressure on fresh water supplies and to new opportunities for growth of potentially pathogenic organisms. PMID:21453515

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis and computer science

NASA Technical Reports Server (NTRS)

1987-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period April, 1986 through September 30, 1986 is summarized.

Making Recycled Paper: An Engineering Design Challenge

ERIC Educational Resources Information Center

Song, Ting; Becker, Kurt

2013-01-01

Science, technology, engineering, and mathematics (STEM) educators are facing the challenge of attracting more students. The disparity between the need for engineers and the enrollment of engineering students is growing (Genalo, Bruning, & Adams, 2000), and career aspirations of high school students are inconsistent with the employment…

Development of Cryogenic Engine for GSLV MkIII: Technological Challenges

NASA Astrophysics Data System (ADS)

Praveen, RS; Jayan, N.; Bijukumar, KS; Jayaprakash, J.; Narayanan, V.; Ayyappan, G.

2017-02-01

Cryogenic engine capable of delivering 200 kN thrust is being developed for the first time in the country by ISRO for powering the upper stage of GSLV Mk-III, the next generation launch vehicle of ISRO capable of launching four tonne class satellites to Geo-synchronous Transfer Orbit(GTO). Development of this engine started a decade ago when various sub-systems development and testing were taken up. Starting with injector element development, the design, realization and testing of the major sub-systems viz the gas generator, turbopumps, start-up system and thrust chamber have been successfully done in a phased manner before conducting a series of developmental tests in the integrated engine mode. Apart from the major sub-systems, many critical components like the igniter, control components etc were independently developed and qualified. During the development program many challenges were faced in almost all areas of propulsion engineering. Systems engineering of the engine was another key challenge in the realization. This paper gives an outlook on various technological challenges faced in the key areas related to the engine development, insight to the solutions and measures taken to overcome the challenges.

Error Estimation and Uncertainty Propagation in Computational Fluid Mechanics

NASA Technical Reports Server (NTRS)

Zhu, J. Z.; He, Guowei; Bushnell, Dennis M. (Technical Monitor)

2002-01-01

Numerical simulation has now become an integral part of engineering design process. Critical design decisions are routinely made based on the simulation results and conclusions. Verification and validation of the reliability of the numerical simulation is therefore vitally important in the engineering design processes. We propose to develop theories and methodologies that can automatically provide quantitative information about the reliability of the numerical simulation by estimating numerical approximation error, computational model induced errors and the uncertainties contained in the mathematical models so that the reliability of the numerical simulation can be verified and validated. We also propose to develop and implement methodologies and techniques that can control the error and uncertainty during the numerical simulation so that the reliability of the numerical simulation can be improved.

New Developments of Computational Fluid Dynamics and Their Applications to Practical Engineering Problems

NASA Astrophysics Data System (ADS)

Chen, Hudong

2001-06-01

There have been considerable advances in Lattice Boltzmann (LB) based methods in the last decade. By now, the fundamental concept of using the approach as an alternative tool for computational fluid dynamics (CFD) has been substantially appreciated and validated in mainstream scientific research and in industrial engineering communities. Lattice Boltzmann based methods possess several major advantages: a) less numerical dissipation due to the linear Lagrange type advection operator in the Boltzmann equation; b) local dynamic interactions suitable for highly parallel processing; c) physical handling of boundary conditions for complicated geometries and accurate control of fluxes; d) microscopically consistent modeling of thermodynamics and of interface properties in complex multiphase flows. It provides a great opportunity to apply the method to practical engineering problems encountered in a wide range of industries from automotive, aerospace to chemical, biomedical, petroleum, nuclear, and others. One of the key challenges is to extend the applicability of this alternative approach to regimes of highly turbulent flows commonly encountered in practical engineering situations involving high Reynolds numbers. Over the past ten years, significant efforts have been made on this front at Exa Corporation in developing a lattice Boltzmann based commercial CFD software, PowerFLOW. It has become a useful computational tool for the simulation of turbulent aerodynamics in practical engineering problems involving extremely complex geometries and flow situations, such as in new automotive vehicle designs world wide. In this talk, we present an overall LB based algorithm concept along with certain key extensions in order to accurately handle turbulent flows involving extremely complex geometries. To demonstrate the accuracy of turbulent flow simulations, we provide a set of validation results for some well known academic benchmarks. These include straight channels, backward-facing steps, flows over a curved hill and typical NACA airfoils at various angles of attack including prediction of stall angle. We further provide numerous engineering cases, ranging from external aerodynamics around various car bodies to internal flows involved in various industrial devices. We conclude with a discussion of certain future extensions for complex fluids.

Incorporating Engineering Design Challenges into STEM Courses

ERIC Educational Resources Information Center

Householder, Daniel L., Ed.; Hailey, Christine E., Ed.

2012-01-01

Successful strategies for incorporating engineering design challenges into science, technology, engineering, and mathematics (STEM) courses in American high schools are presented in this paper. The developers have taken the position that engineering design experiences should be an important component of the high school education of all American…

The New Global Responsibilities of Engineers Create Challenges for Engineering Education

ERIC Educational Resources Information Center

Fuchs, Willi

2012-01-01

Modern societies aim to solve the global challenges of the 21st century with sustainable solutions such as resource efficiency, use of renewable energy sources and recycling. Engineers are called upon to create the cutting edge technological solutions that can help to address these challenges. In developed as well as in developing countries,…

Bulk Magnetization Effects in EMI-Based Classification and Discrimination

DTIC Science & Technology

2012-04-01

response adds to classification performance and ( 2 ) develop a comprehensive understanding of the engineering challenges of primary field cancellation...response adds to classification performance and ( 2 ) develop a comprehensive understanding of the engineering challenges of primary field cancellation...classification performance and ( 2 ) develop a comprehensive understanding of the engineering challenges of primary field cancellation that can support a

The implications of recent advances in carboxymethyl chitosan based targeted drug delivery and tissue engineering applications.

PubMed

Upadhyaya, Laxmi; Singh, Jay; Agarwal, Vishnu; Tewari, Ravi Prakash

2014-07-28

Over the last decade carboxymethyl chitosan (CMCS) has emerged as a promising biopolymer for the development of new drug delivery systems and improved scaffolds along with other tissue engineering devices for regenerative medicine that is currently one of the most rapidly growing fields in the life sciences. CMCS is amphiprotic ether, derived from chitosan, exhibiting enhanced aqueous solubility, excellent biocompatibility, controllable biodegradability, osteogenesis ability and numerous other outstanding physicochemical and biological properties. More strikingly, it can load hydrophobic drugs and displays strong bioactivity which highlight its suitability and extensive usage for preparing different drug delivery and tissue engineering formulations respectively. This review provides a comprehensive introduction to various types of CMCS based formulations for delivery of therapeutic agents and tissue regeneration and further describes their preparation procedures and applications in different tissues/organs. Detailed information of CMCS based nano/micro systems for targeted delivery of drugs with emphasis on cancer specific and organ specific drug delivery have been described. Further, we have discussed various CMCS based tissue engineering biomaterials along with their preparation procedures and applications in different tissues/organs. The article then, gives a brief account of therapy combining drug delivery and tissue engineering. Finally, identification of major challenges and opportunities for current and ongoing application of CMCS based systems in the field are summarised. Copyright © 2014 Elsevier B.V. All rights reserved.

Tough and tunable adhesion of hydrogels: experiments and models

NASA Astrophysics Data System (ADS)

Zhang, Teng; Yuk, Hyunwoo; Lin, Shaoting; Parada, German A.; Zhao, Xuanhe

2017-06-01

As polymer networks infiltrated with water, hydrogels are major constituents of animal and plant bodies and have diverse engineering applications. While natural hydrogels can robustly adhere to other biological materials, such as bonding of tendons and cartilage on bones and adhesive plaques of mussels, it is challenging to achieve such tough adhesions between synthetic hydrogels and engineering materials. Recent experiments show that chemically anchoring long-chain polymer networks of tough synthetic hydrogels on solid surfaces create adhesions tougher than their natural counterparts, but the underlying mechanism has not been well understood. It is also challenging to tune systematically the adhesion of hydrogels on solids. Here, we provide a quantitative understanding of the mechanism for tough adhesions of hydrogels on solid materials via a combination of experiments, theory, and numerical simulations. Using a coupled cohesive-zone and Mullins-effect model validated by experiments, we reveal the interplays of intrinsic work of adhesion, interfacial strength, and energy dissipation in bulk hydrogels in order to achieve tough adhesions. We further show that hydrogel adhesion can be systematically tuned by tailoring the hydrogel geometry and silanization time of solid substrates, corresponding to the control of energy dissipation zone and intrinsic work of adhesion, respectively. The current work further provides a theoretical foundation for rational design of future biocompatible and underwater adhesives.

Designing to Sample the Unknown: Lessons from OSIRIS-REx Project Systems Engineering

NASA Technical Reports Server (NTRS)

Everett, David; Mink, Ronald; Linn, Timothy; Wood, Joshua

2017-01-01

On September 8, 2016, the third NASA New Frontiers mission launched on an Atlas V 411. The Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer (OSIRIS-REx) will rendezvous with asteroid Bennu in 2018, collect a sample in 2020, and return that sample to Earth in September 2023. The development team has overcome a number of challenges in order to design and build a system that will make contact with an unexplored, airless, low-gravity body. This paper will provide an overview of the mission, then focus in on the system-level challenges and some of the key system-level processes. Some of the lessons here are unique to the type of mission, like discussion of operating at a largely-unknown, low-gravity object. Other lessons, particularly from the build phase, have broad implications. The OSIRIS-REx risk management process was particularly effective in achieving an on-time and under-budget development effort. The systematic requirements management and verification and the system validation also helped identify numerous potential problems. The final assessment of the OSIRIS-REx performance will need to wait until the sample is returned in 2023, but this post-launch assessment will capture some of the key systems-engineering lessons from the development team.

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis and computer science

NASA Technical Reports Server (NTRS)

1988-01-01

This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period April l, 1988 through September 30, 1988.

Summary of research in applied mathematics, numerical analysis and computer science at the Institute for Computer Applications in Science and Engineering

NASA Technical Reports Server (NTRS)

1984-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis and computer science during the period October 1, 1983 through March 31, 1984 is summarized.

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis and computer science

NASA Technical Reports Server (NTRS)

1987-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period October 1, 1986 through March 31, 1987 is summarized.

ICASE semiannual report, April 1 - September 30, 1989

NASA Technical Reports Server (NTRS)

1990-01-01

The Institute conducts unclassified basic research in applied mathematics, numerical analysis, and computer science in order to extend and improve problem-solving capabilities in science and engineering, particularly in aeronautics and space. The major categories of the current Institute for Computer Applications in Science and Engineering (ICASE) research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification problems, with emphasis on effective numerical methods; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software, especially vector and parallel computers. ICASE reports are considered to be primarily preprints of manuscripts that have been submitted to appropriate research journals or that are to appear in conference proceedings.

The roles of engineering notebooks in shaping elementary engineering student discourse and practice

NASA Astrophysics Data System (ADS)

Hertel, Jonathan D.; Cunningham, Christine M.; Kelly, Gregory J.

2017-06-01

Engineering design challenges offer important opportunities for students to learn science and engineering knowledge and practices. This study examines how students' engineering notebooks across four units of the curriculum Engineering is Elementary (EiE) support student work during design challenges. Through educational ethnography and discourse analysis, transcripts of student talk and action were created and coded around the uses of notebooks in the accomplishment of engineering tasks. Our coding process identified two broad categories of roles of the notebooks: they scaffold student activity and support epistemic practices of engineering. The study showed the importance of prompts to engage students in effective uses of writing, the roles the notebook assumes in the students' small groups, and the ways design challenges motivate children to write and communicate.

Microcomputed Tomography Characterization of Neovascularization in Bone Tissue Engineering Applications

PubMed Central

Young, Simon; Kretlow, James D.; Nguyen, Charles; Bashoura, Alex G.; Baggett, L. Scott; Jansen, John A.; Wong, Mark

2008-01-01

Abstract Vasculogenesis and angiogenesis have been studied for decades using numerous in vitro and in vivo systems, fulfilling the need to elucidate the mechanisms involved in these processes and to test potential therapeutic agents that inhibit or promote neovascularization. Bone tissue engineering in particular has benefited from the application of proangiogenic strategies, considering the need for an adequate vascular supply during healing and the challenges associated with the vascularization of scaffolds implanted in vivo. Conventional methods of assessing the in vivo angiogenic response to tissue-engineered constructs tend to rely on a two-dimensional assessment of microvessel density within representative histological sections without elaboration of the true vascular tree. The introduction of microcomputed tomography (micro-CT) has recently allowed investigators to obtain a diverse range of high-resolution, three-dimensional characterization of structures, including renal, coronary, and hepatic vascular networks, as well as bone formation within healing defects. To date, few studies have utilized micro-CT to study the vascular response to an implanted tissue engineering scaffold. In this paper, conventional in vitro and in vivo models for studying angiogenesis will be discussed, followed by recent developments in the use of micro-CT for vessel imaging in bone tissue engineering research. A new study demonstrating the potential of contrast-enhanced micro-CT for the evaluation of in vivo neovascularization in bony defects is described, which offers significant potential in the evaluation of bone tissue engineering constructs. PMID:18657028

Building better bone: The weaving of biologic and engineering strategies for managing bone loss.

PubMed

Schwartz, Andrew M; Schenker, Mara L; Ahn, Jaimo; Willett, Nick J

2017-09-01

Segmental bone loss remains a challenging clinical problem for orthopaedic trauma surgeons. In addition to the missing bone itself, the local tissues (soft tissue, vascular) are often highly traumatized as well, resulting in a less than ideal environment for bone regeneration. As a result, attempts at limb salvage become a highly expensive endeavor, often requiring multiple operations and necessitating the use of every available strategy (autograft, allograft, bone graft substitution, Masquelet, bone transport, etc.) to achieve bony union. A cost-sensitive, functionally appropriate, and volumetrically adequate engineered substitute would be practice-changing for orthopaedic trauma surgeons and these patients with difficult clinical problems. In tissue engineering and bone regeneration fields, numerous research efforts continue to make progress toward new therapeutic interventions for segmental bone loss, including novel biomaterial development as well as cell-based strategies. Despite an ever-evolving literature base of these new therapeutic and engineered options, there remains a disconnect with the clinical practice, with very few translating into clinical use. A symposium entitled "Building better bone: The weaving of biologic and engineering strategies for managing bone loss," was presented at the 2016 Orthopaedic Research Society Conference to further explore this engineering-clinical disconnect, by surveying basic, translational, and clinical researchers along with orthopaedic surgeons and proposing ideas for pushing the bar forward in the field of segmental bone loss. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1855-1864, 2017. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Women in Engineering Program Advocates Network (WEPAN): Evaluation of the seventh annual conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brainard, S.G.

1996-08-01

The primary goals of the 1996 WEPAN Conference were to: (1) Conduct technical and programmatic seminars for institutions desiring to initiate, replicate, or expand women in engineering programs; (2) Provide assistance in fundraising and grant writing; (3) Profile women in engineering programs of excellence; (4) Sponsor inspiring, knowledgeable and motivational keynote speakers; and, (5) Offer a series of workshops focused on topics such as: establishing partnerships with industry, current research findings, retention strategies, issues affecting special populations, and early intervention techniques. In an effort to provide greater access for women to engineering careers, women in engineering program directors at Purduemore » University, Stevens Institute of Technology and the University of Washington joined together in 1990 to establish WEPAN, a national network of individuals interested in the recruitment, admission, retention, and graduation of women engineering students. This is the seventh year of operation. Success of this effort has been reflected in numerous ways: increased membership in the organization; increased number of women in engineering programs; increased number of women graduating in engineering; and grants from the U.S. Department of Energy, the National Science Foundation, the Alfred P. Sloan Foundation, the AT&T Foundation, and many other corporations to carry out the goals of WEPAN. The Seventh Annual Women in Engineering Conference entitled, Capitalizing on Today`s Challenges, was held in Denver, Colorado on June 1-4, 1996 at the Hyatt Regency. The conference brought together representatives from academia, government, and industry and examined current issues and initiatives for women in technology, science, and education. Building on the successes of the previous conferences, the seventh conference offered a new variety of speakers and topics.« less

Engine dynamic analysis with general nonlinear finite element codes. Part 2: Bearing element implementation overall numerical characteristics and benchmaking

NASA Technical Reports Server (NTRS)

Padovan, J.; Adams, M.; Fertis, J.; Zeid, I.; Lam, P.

1982-01-01

Finite element codes are used in modelling rotor-bearing-stator structure common to the turbine industry. Engine dynamic simulation is used by developing strategies which enable the use of available finite element codes. benchmarking the elements developed are benchmarked by incorporation into a general purpose code (ADINA); the numerical characteristics of finite element type rotor-bearing-stator simulations are evaluated through the use of various types of explicit/implicit numerical integration operators. Improving the overall numerical efficiency of the procedure is improved.

Preparing Engineers for the Challenges of Community Engagement

ERIC Educational Resources Information Center

Harsh, Matthew; Bernstein, Michael J.; Wetmore, Jameson; Cozzens, Susan; Woodson, Thomas; Castillo, Rafael

2017-01-01

Despite calls to address global challenges through community engagement, engineers are not formally prepared to engage with communities. Little research has been done on means to address this "engagement gap" in engineering education. We examine the efficacy of an intensive, two-day Community Engagement Workshop for engineers, designed…

Iteration in Early-Elementary Engineering Design

NASA Astrophysics Data System (ADS)

McFarland Kendall, Amber Leigh

K-12 standards and curricula are beginning to include engineering design as a key practice within Science Technology Engineering and Mathematics (STEM) education. However, there is little research on how the youngest students engage in engineering design within the elementary classroom. This dissertation focuses on iteration as an essential aspect of engineering design, and because research at the college and professional level suggests iteration improves the designer's understanding of problems and the quality of design solutions. My research presents qualitative case studies of students in kindergarten and third-grade as they engage in classroom engineering design challenges which integrate with traditional curricula standards in mathematics, science, and literature. I discuss my results through the lens of activity theory, emphasizing practices, goals, and mediating resources. Through three chapters, I provide insight into how early-elementary students iterate upon their designs by characterizing the ways in which lesson design impacts testing and revision, by analyzing the plan-driven and experimentation-driven approaches that student groups use when solving engineering design challenges, and by investigating how students attend to constraints within the challenge. I connect these findings to teacher practices and curriculum design in order to suggest methods of promoting iteration within open-ended, classroom-based engineering design challenges. This dissertation contributes to the field of engineering education by providing evidence of productive engineering practices in young students and support for the value of engineering design challenges in developing students' participation and agency in these practices.

Enabling Engineering Student Success: The Final Report for the Center for the Advancement of Engineering Education. CAEE-TR-10-02

ERIC Educational Resources Information Center

Atman, Cynthia J.; Sheppard, Sheri D.; Turns, Jennifer; Adams, Robin S.; Fleming, Lorraine N.; Stevens, Reed; Streveler, Ruth A.; Smith, Karl A.; Miller, Ronald L.; Leifer, Larry J.; Yasuhara, Ken; Lund, Dennis

2010-01-01

Today's engineering graduates will solve tomorrow's problems in a world that is advancing faster and facing more critical challenges than ever before. This situation creates significant demand for engineering education to evolve in order to effectively prepare a diverse community of engineers for these challenges. Such concerns have led to the…

Summary of research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis and computer science

NASA Technical Reports Server (NTRS)

1989-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period October 1, 1988 through March 31, 1989 is summarized.

Relating a Jet-Surface Interaction Experiment to a Commercial Supersonic Transport Aircraft Using Numerical Simulations

NASA Technical Reports Server (NTRS)

Dippold, Vance F., III; Friedlander, David

2017-01-01

NASA and industry partners desire to reintroduce commercial supersonic airliners to the air transportation system. There are a number of technical challenges that must be overcome by future commercial supersonic airliners to make them viable solutions in society. NASA is specifically concerned with the challenges of reducing boom during supersonic cruise, maximizing range, and reducing airport community noise to acceptable levels. Concepts for commercial supersonic transports, such as the concept aircraft by Lockheed Martin pictured in Figure 1, place the engine nozzles in close proximity to wing and tail surfaces. However, the effects of noise shielding and noise radiation are not fully understood for installed propulsion systems. A series of acoustic tests were conducted on the NASA Glenn Research Centers Nozzle Acoustic Test Rig (NATR) to address the challenge of reducing airport community noise, which is often dominated by jet noise. To best represent the conceptual aircraft in the acoustic tests, noise measurements were taken of the jet in close proximity of simulated aerodynamic surfaces, not simply of an isolated jet.

DOE Advanced Scientific Computing Advisory Subcommittee (ASCAC) Report: Top Ten Exascale Research Challenges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lucas, Robert; Ang, James; Bergman, Keren

2014-02-10

Exascale computing systems are essential for the scientific fields that will transform the 21st century global economy, including energy, biotechnology, nanotechnology, and materials science. Progress in these fields is predicated on the ability to perform advanced scientific and engineering simulations, and analyze the deluge of data. On July 29, 2013, ASCAC was charged by Patricia Dehmer, the Acting Director of the Office of Science, to assemble a subcommittee to provide advice on exascale computing. This subcommittee was directed to return a list of no more than ten technical approaches (hardware and software) that will enable the development of a systemmore » that achieves the Department's goals for exascale computing. Numerous reports over the past few years have documented the technical challenges and the non¬-viability of simply scaling existing computer designs to reach exascale. The technical challenges revolve around energy consumption, memory performance, resilience, extreme concurrency, and big data. Drawing from these reports and more recent experience, this ASCAC subcommittee has identified the top ten computing technology advancements that are critical to making a capable, economically viable, exascale system.« less

Designing Mission Operations for the Gravity Recovery and Interior Laboratory Mission

NASA Technical Reports Server (NTRS)

Havens, Glen G.; Beerer, Joseph G.

2012-01-01

NASA's Gravity Recovery and Interior Laboratory (GRAIL) mission, to understand the internal structure and thermal evolution of the Moon, offered unique challenges to mission operations. From launch through end of mission, the twin GRAIL orbiters had to be operated in parallel. The journey to the Moon and into the low science orbit involved numerous maneuvers, planned on tight timelines, to ultimately place the orbiters into the required formation-flying configuration necessary. The baseline GRAIL mission is short, only 9 months in duration, but progressed quickly through seven very unique mission phases. Compressed into this short mission timeline, operations activities and maneuvers for both orbiters had to be planned and coordinated carefully. To prepare for these challenges, development of the GRAIL Mission Operations System began in 2008. Based on high heritage multi-mission operations developed by NASA's Jet Propulsion Laboratory and Lockheed Martin, the GRAIL mission operations system was adapted to meet the unique challenges posed by the GRAIL mission design. This paper describes GRAIL's system engineering development process for defining GRAIL's operations scenarios and generating requirements, tracing the evolution from operations concept through final design, implementation, and validation.

Common Analysis Tool Being Developed for Aeropropulsion: The National Cycle Program Within the Numerical Propulsion System Simulation Environment

NASA Technical Reports Server (NTRS)

Follen, Gregory J.; Naiman, Cynthia G.

1999-01-01

The NASA Lewis Research Center is developing an environment for analyzing and designing aircraft engines-the Numerical Propulsion System Simulation (NPSS). NPSS will integrate multiple disciplines, such as aerodynamics, structure, and heat transfer, and will make use of numerical "zooming" on component codes. Zooming is the coupling of analyses at various levels of detail. NPSS uses the latest computing and communication technologies to capture complex physical processes in a timely, cost-effective manner. The vision of NPSS is to create a "numerical test cell" enabling full engine simulations overnight on cost-effective computing platforms. Through the NASA/Industry Cooperative Effort agreement, NASA Lewis and industry partners are developing a new engine simulation called the National Cycle Program (NCP). NCP, which is the first step toward NPSS and is its initial framework, supports the aerothermodynamic system simulation process for the full life cycle of an engine. U.S. aircraft and airframe companies recognize NCP as the future industry standard common analysis tool for aeropropulsion system modeling. The estimated potential payoff for NCP is a $50 million/yr savings to industry through improved engineering productivity.

A study of the displacement of a Wankel rotary engine

NASA Astrophysics Data System (ADS)

Beard, J. E.; Pennock, G. R.

1993-03-01

The volumetric displacement of a Wankel rotary engine is a function of the trochoid ratio and the pin size ratio, assuming the engine has a unit depth and the number of lobes is specified. The mathematical expression which defines the displacement contains a function which can be evaluated directly and a normal elliptic integral of the second type which does not have an explicit solution. This paper focuses on the contribution of the elliptic integral to the total displacement of the engine. The influence of the elliptic integral is shown to account for as much as 20 percent of the total displacement, depending on the trochoid ratio and the pin size ratio. Two numerical integration techniques are compared in the paper, namely, the trapezoidal rule and Simpson's 1/3 rule. The bounds on the error, associated with each numerical method, are analyzed. The results indicate that the numerical method has a minimal effect on the accuracy of the calculated displacement for a practical number of integration steps. The paper also evaluates the influence of manufacturing tolerances on the calculated displacement and the actual displacement. Finally. a numerical example of the common three-lobed Wankel rotary engine is included for illustrative purposes.

Semiannual report, 1 April - 30 September 1991

NASA Technical Reports Server (NTRS)

1991-01-01

The major categories of the current Institute for Computer Applications in Science and Engineering (ICASE) research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification problems, with emphasis on effective numerical methods; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software for parallel computers. Research in these areas is discussed.

Constrained and Unconstrained Variational Finite Element Formulation of Solutions to a Stress Wave Problem - a Numerical Comparison.

DTIC Science & Technology

1982-10-01

Element Unconstrained Variational Formulations," Innovativ’e Numerical Analysis For the Applied Engineering Science, R. P. Shaw, et at, Fitor...Initial Boundary Value of Gun Dynamics Solved by Finite Element Unconstrained Variational Formulations," Innovative Numerical Analysis For the Applied ... Engineering Science, R. P. Shaw, et al, Editors, University Press of Virginia, Charlottesville, pp. 733-741, 1980. 2 J. J. Wu, "Solutions to Initial

Challenges Faced by Female-Students in Engineering-Education

ERIC Educational Resources Information Center

Madara, Diana Starovoytova; Cherotich, Sharon

2016-01-01

Gender-related challenges in learning technical courses are universal phenomenon. These challenges could restrain female students from achieving their fullest potential. The main focus of this study, therefore, is to examine self-recognized challenges faced by undergraduate female students in pursuing engineering at the School of Engineering…

Research in progress in applied mathematics, numerical analysis, and computer science

NASA Technical Reports Server (NTRS)

1990-01-01

Research conducted at the Institute in Science and Engineering in applied mathematics, numerical analysis, and computer science is summarized. The Institute conducts unclassified basic research in applied mathematics in order to extend and improve problem solving capabilities in science and engineering, particularly in aeronautics and space.

Evaluating Blended and Flipped Instruction in Numerical Methods at Multiple Engineering Schools

ERIC Educational Resources Information Center

Clark, Renee; Kaw, Autar; Lou, Yingyan; Scott, Andrew; Besterfield-Sacre, Mary

2018-01-01

With the literature calling for comparisons among technology-enhanced or active-learning pedagogies, a blended versus flipped instructional comparison was made for numerical methods coursework using three engineering schools with diverse student demographics. This study contributes to needed comparisons of enhanced instructional approaches in STEM…

Identifying the Challenging Factors in the Transition from Colleges of Engineering to Employment

ERIC Educational Resources Information Center

Baytiyeh, Hoda; Naja, Mohamad

2012-01-01

The transition from university to a career in engineering is a challenging process. This study examined the perceptions of engineering graduates regarding the difficulties they encountered in their transition from the university to the workplace. Lebanese practising engineers (n=217), living around the world, were surveyed to identify their…

Enhanced nutrient transport improves the depth-dependent properties of tri-layered engineered cartilage constructs with zonal co-culture of chondrocytes and MSCs.

PubMed

Kim, Minwook; Farrell, Megan J; Steinberg, David R; Burdick, Jason A; Mauck, Robert L

2017-08-01

Biomimetic design in cartilage tissue engineering is a challenge given the complexity of the native tissue. While numerous studies have generated constructs with near-native bulk properties, recapitulating the depth-dependent features of native tissue remains a challenge. Furthermore, limitations in nutrient transport and matrix accumulation in engineered constructs hinders maturation within the central core of large constructs. To overcome these limitations, we fabricated tri-layered constructs that recapitulate the depth-dependent cellular organization and functional properties of native tissue using zonally derived chondrocytes co-cultured with MSCs. We also introduced porous hollow fibers (HFs) and HFs/cotton threads to enhance nutrient transport. Our results showed that tri-layered constructs with depth-dependent organization and properties could be fabricated. The addition of HFs or HFs/threads improved matrix accumulation in the central core region. With HF/threads, the local modulus in the deep region of tri-layered constructs nearly matched that of native tissue, though the properties in the central regions remained lower. These constructs reproduced the zonal organization and depth-dependent properties of native tissue, and demonstrate that a layer-by-layer fabrication scheme holds promise for the biomimetic repair of focal cartilage defects. Articular cartilage is a highly organized tissue driven by zonal heterogeneity of cells, extracellular matrix proteins and fibril orientations, resulting in depth-dependent mechanical properties. Therefore, the recapitulation of the functional properties of native cartilage in a tissue engineered construct requires such a biomimetic design of the morphological organization, and this has remained a challenge in cartilage tissue engineering. This study demonstrates that a layer-by-layer fabrication scheme, including co-cultures of zone-specific articular CHs and MSCs, can reproduce the depth-dependent characteristics and mechanical properties of native cartilage while minimizing the need for large numbers of chondrocytes. In addition, introduction of a porous hollow fiber (combined with a cotton thread) enhanced nutrient transport and depth-dependent properties of the tri-layered construct. Such a tri-layered construct may provide critical advantages for focal cartilage repair. These constructs hold promise for restoring native tissue structure and function, and may be beneficial in terms of zone-to-zone integration with adjacent host tissue and providing more appropriate strain transfer after implantation. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Evaluation of Interfacial Forces and Bubble-Induced Turbulence Using Direct Numerical Simulation

NASA Astrophysics Data System (ADS)

Feng, Jinyong

High fidelity prediction of multiphase flows is important in a wide range of engineering applications. While some multiphase flow scenarios can be successfully modeled, many questions remain unanswered regarding the interaction between the bubbles and the turbulence, and present significant challenges in the development of closure laws for the multiphase computational fluid dynamics (M-CFD) models. To address these challenges, we propose to evaluate the interfacial forces and bubble-induced turbulence in both laminar and turbulent flow field with direct numerical simulation (DNS) approach. Advanced finite-element based flow solver (PHASTA) with level-set interface tracking method is utilized for these studies. The proportional-integral-derivative (PID) controller is adopted to ensure the statistically steady state bubble position and perform the detailed study of the turbulent field around the bubble. Selected numerical capabilities and post-processing codes are developed to achieve the research goals. The interface tracking approach is verified and validated by comparing the interfacial forces with the experiment-based data and correlations. The sign change of transverse lift force is observed as the bubble becomes more deformable. A new correlation is proposed to predict the behavior of the drag coefficient over the wide range of conditions. The wall effect on the interfacial forces are also investigated. In homogeneous turbulent flow, the effect of bubble deformability, turbulent intensity and relative velocity on the bubble-induced turbulence are analyzed. The presented method and novel results will complement the experimental database, provide insight to the bubbleinduced turbulence mechanism and help the development of M-CFD closure models.

Women in engineering conference: capitalizing on today`s challenges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Metz, S.S.; Martins, S.M.

This document contains the conference proceedings of the Women in Engineering Conference: Capitalizing on Today`s Challenges, held June 1-4, 1996 in Denver, Colorado. Topics included engineering and science education, career paths, workplace issues, and affirmative action.

Low cycle fatigue numerical estimation of a high pressure turbine disc for the AL-31F jet engine

NASA Astrophysics Data System (ADS)

Spodniak, Miroslav; Klimko, Marek; Hocko, Marián; Žitek, Pavel

This article deals with the description of an approximate numerical estimation approach of a low cycle fatigue of a high pressure turbine disc for the AL-31F turbofan jet engine. The numerical estimation is based on the finite element method carried out in the SolidWorks software. The low cycle fatigue assessment of a high pressure turbine disc was carried out on the basis of dimensional, shape and material disc characteristics, which are available for the particular high pressure engine turbine. The method described here enables relatively fast setting of economically feasible low cycle fatigue of the assessed high pressure turbine disc using a commercially available software. The numerical estimation of accuracy of a low cycle fatigue depends on the accuracy of required input data for the particular investigated object.

A numerical model on thermodynamic analysis of free piston Stirling engines

NASA Astrophysics Data System (ADS)

Mou, Jian; Hong, Guotong

2017-02-01

In this paper, a new numerical thermodynamic model which bases on the energy conservation law has been used to analyze the free piston Stirling engine. In the model all data was taken from a real free piston Stirling engine which has been built in our laboratory. The energy conservation equations have been applied to expansion space and compression space of the engine. The equation includes internal energy, input power, output power, enthalpy and the heat losses. The heat losses include regenerative heat conduction loss, shuttle heat loss, seal leakage loss and the cavity wall heat conduction loss. The numerical results show that the temperature of expansion space and the temperature of compression space vary with the time. The higher regeneration effectiveness, the higher efficiency and bigger output work. It is also found that under different initial pressures, the heat source temperature, phase angle and engine work frequency pose different effects on the engine’s efficiency and power. As a result, the model is expected to be a useful tool for simulation, design and optimization of Stirling engines.

A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches

PubMed Central

Cosgrove, Benjamin D.; Sacco, Alessandra; Gilbert, Penney M.; Blau, Helen M.

2009-01-01

Satellite cells are skeletal muscle stem cells with a principal role in postnatal skeletal muscle regeneration. Satellite cells, like many tissue-specific adult stem cells, reside in a quiescent state in an instructive, anatomically defined niche. The satellite cell niche constitutes a distinct membrane-enclosed compartment within the muscle fiber, containing a diversity of biochemical and biophysical signals that influence satellite cell function. A major limitation to the study and clinical utility of satellite cells is that upon removal from the muscle fiber and plating in traditional plastic tissue culture platforms, their muscle stem cell properties are rapidly lost. Clearly, the maintenance of stem cell function is critically dependent on in vivo niche signals, highlighting the need to create novel in vitro microenvironments that allow for the maintenance and propagation of satellite cells while retaining their potential to function as muscle stem cells. Here, we discuss how emerging biomaterials technologies offer great promise for engineering in vitro microenvironments to meet these challenges. In engineered biomaterials, signaling molecules can be presented in a manner that more closely mimics cell-cell and cell-matrix interactions and matrices can be fabricated with diverse rigidities that approximate in vivo tissues. The development of in vitro microenvironments in which niche features can be systematically modulated will be instrumental not only to future insights into muscle stem cell biology and therapeutic approaches to muscle diseases and muscle wasting with aging, but also will provide a paradigm for the analysis of numerous adult tissue-specific stem cells. PMID:19751902

Antarctic subglacial lake exploration: first results and future plans

PubMed Central

Siegert, Martin J.; Priscu, John C.; Wadham, Jemma L.; Lyons, W. Berry

2016-01-01

After more than a decade of planning, three attempts were made in 2012–2013 to access, measure in situ properties and directly sample subglacial Antarctic lake environments. First, Russian scientists drilled into the top of Lake Vostok, allowing lake water to infiltrate, and freeze within, the lower part of the ice-core borehole, from which further coring would recover a frozen sample of surface lake water. Second, UK engineers tried unsuccessfully to deploy a clean-access hot-water drill, to sample the water column and sediments of subglacial Lake Ellsworth. Third, a US mission successfully drilled cleanly into subglacial Lake Whillans, a shallow hydraulically active lake at the coastal margin of West Antarctica, obtaining samples that would later be used to prove the existence of microbial life and active biogeochemical cycling beneath the ice sheet. This article summarizes the results of these programmes in terms of the scientific results obtained, the operational knowledge gained and the engineering challenges revealed, to collate what is known about Antarctic subglacial environments and how to explore them in future. While results from Lake Whillans testify to subglacial lakes as being viable biological habitats, the engineering challenges to explore deeper more isolated lakes where unique microorganisms and climate records may be found, as exemplified in the Lake Ellsworth and Vostok missions, are considerable. Through international cooperation, and by using equipment and knowledge of the existing subglacial lake exploration programmes, it is possible that such environments could be explored thoroughly, and at numerous sites, in the near future. PMID:26667917

Antarctic subglacial lake exploration: first results and future plans.

PubMed

Siegert, Martin J; Priscu, John C; Alekhina, Irina A; Wadham, Jemma L; Lyons, W Berry

2016-01-28

After more than a decade of planning, three attempts were made in 2012-2013 to access, measure in situ properties and directly sample subglacial Antarctic lake environments. First, Russian scientists drilled into the top of Lake Vostok, allowing lake water to infiltrate, and freeze within, the lower part of the ice-core borehole, from which further coring would recover a frozen sample of surface lake water. Second, UK engineers tried unsuccessfully to deploy a clean-access hot-water drill, to sample the water column and sediments of subglacial Lake Ellsworth. Third, a US mission successfully drilled cleanly into subglacial Lake Whillans, a shallow hydraulically active lake at the coastal margin of West Antarctica, obtaining samples that would later be used to prove the existence of microbial life and active biogeochemical cycling beneath the ice sheet. This article summarizes the results of these programmes in terms of the scientific results obtained, the operational knowledge gained and the engineering challenges revealed, to collate what is known about Antarctic subglacial environments and how to explore them in future. While results from Lake Whillans testify to subglacial lakes as being viable biological habitats, the engineering challenges to explore deeper more isolated lakes where unique microorganisms and climate records may be found, as exemplified in the Lake Ellsworth and Vostok missions, are considerable. Through international cooperation, and by using equipment and knowledge of the existing subglacial lake exploration programmes, it is possible that such environments could be explored thoroughly, and at numerous sites, in the near future. © 2015 The Author(s).

Thermomechanical Properties of Polylactic Acid-Graphene Composites: A State-of-the-Art Review for Biomedical Applications

PubMed Central

2017-01-01

Due to its biodegradable and bioabsorbable characteristics polylactic acid (PLA) has attracted considerable attention for numerous biomedical applications. Moreover, a number of tissue engineering problems for function restoration of impaired tissues have been addressed by using PLA and its copolymers due to their biocompatibility and distinctive mechanical properties. Recent studies on various stereocomplex formation between enantiomeric PLA, poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA) indicated that stereocomplexation enhances the mechanical properties as well as the thermal- and hydrolysis-resistance of PLA polymers. On the other hand, biomedical application of graphene is a relatively new front with significant potential. Many recent reports have indicated that understanding of graphene-cell (or tissue, organ) interactions; particularly the cellular uptake mechanisms are still challenging. Therefore, use of graphene or graphene oxide properly embedded in suitable PLA matrices can positively impact and accelerate the growth, differentiation, and proliferation of stem cells, conceivably minimizing concerns over cytotoxicity of graphene. As such, PLA-graphene composites hold great promise in tissue engineering, regenerative medicine, and in other biomedical fields. However, since PLA is classified as a hard bio-polyester prone to hydrolysis, understanding and engineering of thermo-mechanical properties of PLA-graphene composites are very crucial for such cutting-edge applications. Hence, this review aims to present an overview of current advances in the preparation and applications of PLA-graphene composites and their properties with focus on various biomedical uses such as scaffolds, drug delivery, cancer therapy, and biological imaging, together with a brief discussion on the challenges and perspectives for future research in this field. PMID:28773109

Numerical investigation of CAI Combustion in the Opposed- Piston Engine with Direct and Indirect Water Injection

NASA Astrophysics Data System (ADS)

Pyszczek, R.; Mazuro, P.; Teodorczyk, A.

2016-09-01

This paper is focused on the CAI combustion control in a turbocharged 2-stroke Opposed-Piston (OP) engine. The barrel type OP engine arrangement is of particular interest for the authors because of its robust design, high mechanical efficiency and relatively easy incorporation of a Variable Compression Ratio (VCR). The other advantage of such design is that combustion chamber is formed between two moving pistons - there is no additional cylinder head to be cooled which directly results in an increased thermal efficiency. Furthermore, engine operation in a Controlled Auto-Ignition (CAI) mode at high compression ratios (CR) raises a possibility of reaching even higher efficiencies and very low emissions. In order to control CAI combustion such measures as VCR and water injection were considered for indirect ignition timing control. Numerical simulations of the scavenging and combustion processes were performed with the 3D CFD multipurpose AVL Fire solver. Numerous cases were calculated with different engine compression ratios and different amounts of directly and indirectly injected water. The influence of the VCR and water injection on the ignition timing and engine performance was determined and their application in the real engine was discussed.

Object oriented development of engineering software using CLIPS

NASA Technical Reports Server (NTRS)

Yoon, C. John

1991-01-01

Engineering applications involve numeric complexity and manipulations of a large amount of data. Traditionally, numeric computation has been the concern in developing an engineering software. As engineering application software became larger and more complex, management of resources such as data, rather than the numeric complexity, has become the major software design problem. Object oriented design and implementation methodologies can improve the reliability, flexibility, and maintainability of the resulting software; however, some tasks are better solved with the traditional procedural paradigm. The C Language Integrated Production System (CLIPS), with deffunction and defgeneric constructs, supports the procedural paradigm. The natural blending of object oriented and procedural paradigms has been cited as the reason for the popularity of the C++ language. The CLIPS Object Oriented Language's (COOL) object oriented features are more versatile than C++'s. A software design methodology based on object oriented and procedural approaches appropriate for engineering software, and to be implemented in CLIPS was outlined. A method for sensor placement for Space Station Freedom is being implemented in COOL as a sample problem.

Mathematical modeling of the Stirling engine in terms of applying the composition of the power complex containing non-conventional and renewable energy

NASA Astrophysics Data System (ADS)

Gaponenko, A. M.; Kagramanova, A. A.

2017-11-01

The opportunity of application of Stirling engine with non-conventional and renewable sources of energy. The advantage of such use. The resulting expression for the thermal efficiency of the Stirling engine. It is shown that the work per cycle is proportional to the quantity of matter, and hence the pressure of the working fluid, the temperature difference and, to a lesser extent, depends on the expansion coefficient; efficiency of ideal Stirling cycle coincides with the efficiency of an ideal engine working on the Carnot cycle, which distinguishes a Stirling cycle from the cycles of Otto and Diesel underlying engine. It has been established that the four input parameters, the only parameter which can be easily changed during operation, and which effectively affects the operation of the engine is the phase difference. Dependence of work per cycle of the phase difference, called the phase characteristic, visually illustrates mode of operation of Stirling engine. The mathematical model of the cycle of Schmidt and the analysis of operation of Stirling engine in the approach of Schmidt with the aid of numerical analysis. To conduct numerical experiments designed program feature in the language MathLab. The results of numerical experiments are illustrated by graphical charts.

Self-Assembled Smart Nanocarriers for Targeted Drug Delivery.

PubMed

Cui, Wei; Li, Junbai; Decher, Gero

2016-02-10

Nanostructured drug-carrier systems promise numerous benefits for drug delivery. They can be engineered to precisely control drug-release rates or to target specific sites within the body with a specific amount of therapeutic agent. However, to achieve the best therapeutic effects, the systems should be designed for carrying the optimum amount of a drug to the desired target where it should be released at the optimum rate for a specified time. Despite numerous attempts, fulfilling all of these requirements in a synergistic way remains a huge challenge. The trend in drug delivery is consequently directed toward integrated multifunctional carrier systems, providing selective recognition in combination with sustained or triggered release. Capsules as vesicular systems enable drugs to be confined for controlled release. Furthermore, carriers modified with recognition groups can enhance the capability of encapsulated drug efficacy. Here, recent advances are reviewed regarding designing and preparing assembled capsules with targeting ligands or size controllable for selective recognition in drug delivery. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

H-fractal seismic metamaterial with broadband low-frequency bandgaps

NASA Astrophysics Data System (ADS)

Du, Qiujiao; Zeng, Yi; Xu, Yang; Yang, Hongwu; Zeng, Zuoxun

2018-03-01

The application of metamaterial in civil engineering to achieve isolation of a building by controlling the propagation of seismic waves is a substantial challenge because seismic waves, a superposition of longitudinal and shear waves, are more complex than electromagnetic and acoustic waves. In this paper, we design a broadband seismic metamaterial based on H-shaped fractal pillars and report numerical simulation of band structures for seismic surface waves propagating. Comparative study on the band structures of H-fractal seismic metamaterials with different levels shows that a new level of fractal structure creates new band gap, widens the total band gaps and shifts the same band gap towards lower frequencies. Moreover, the vibration modes for H-fractal seismic metamaterials are computed and analyzed to clarify the mechanism of widening band gaps. A numerical investigation of seismic surface waves propagation on a 2D array of fractal unit cells on the surface of semi-infinite substrate is proposed to show the efficiency of earthquake shielding in multiple complete band gaps.

Numerical investigation of spray ignition of a multi-component fuel surrogate

NASA Astrophysics Data System (ADS)

Backer, Lara; Narayanaswamy, Krithika; Pepiot, Perrine

2014-11-01

Simulating turbulent spray ignition, an important process in engine combustion, is challenging, since it combines the complexity of multi-scale, multiphase turbulent flow modeling with the need for an accurate description of chemical kinetics. In this work, we use direct numerical simulation to investigate the role of the evaporation model on the ignition characteristics of a multi-component fuel surrogate, injected as droplets in a turbulent environment. The fuel is represented as a mixture of several components, each one being representative of a different chemical class. A reduced kinetic scheme for the mixture is extracted from a well-validated detailed chemical mechanism, and integrated into the multiphase turbulent reactive flow solver NGA. Comparisons are made between a single-component evaporation model, in which the evaporating gas has the same composition as the liquid droplet, and a multi-component model, where component segregation does occur. In particular, the corresponding production of radical species, which are characteristic of the ignition of individual fuel components, is thoroughly analyzed.

Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications.

PubMed

Han, Ya-Hui; Kankala, Ranjith Kumar; Wang, Shi-Bin; Chen, Ai-Zheng

2018-05-24

In recent times, photo-induced therapeutics have attracted enormous interest from researchers due to such attractive properties as preferential localization, excellent tissue penetration, high therapeutic efficacy, and minimal invasiveness, among others. Numerous photosensitizers have been considered in combination with light to realize significant progress in therapeutics. Along this line, indocyanine green (ICG), a Food and Drug Administration (FDA)-approved near-infrared (NIR, >750 nm) fluorescent dye, has been utilized in various biomedical applications such as drug delivery, imaging, and diagnosis, due to its attractive physicochemical properties, high sensitivity, and better imaging view field. However, ICG still suffers from certain limitations for its utilization as a molecular imaging probe in vivo, such as concentration-dependent aggregation, poor in vitro aqueous stability and photodegradation due to various physicochemical attributes. To overcome these limitations, much research has been dedicated to engineering numerous multifunctional polymeric composites for potential biomedical applications. In this review, we aim to discuss ICG-encapsulated polymeric nanoconstructs, which are of particular interest in various biomedical applications. First, we emphasize some attractive properties of ICG (including physicochemical characteristics, optical properties, metabolic features, and other aspects) and some of its current limitations. Next, we aim to provide a comprehensive overview highlighting recent reports on various polymeric nanoparticles that carry ICG for light-induced therapeutics with a set of examples. Finally, we summarize with perspectives highlighting the significant outcome, and current challenges of these nanocomposites.

Multi-scale sensitivity analysis of pile installation using DEM

NASA Astrophysics Data System (ADS)

Esposito, Ricardo Gurevitz; Velloso, Raquel Quadros; , Eurípedes do Amaral Vargas, Jr.; Danziger, Bernadete Ragoni

2017-12-01

The disturbances experienced by the soil due to the pile installation and dynamic soil-structure interaction still present major challenges to foundation engineers. These phenomena exhibit complex behaviors, difficult to measure in physical tests and to reproduce in numerical models. Due to the simplified approach used by the discrete element method (DEM) to simulate large deformations and nonlinear stress-dilatancy behavior of granular soils, the DEM consists of an excellent tool to investigate these processes. This study presents a sensitivity analysis of the effects of introducing a single pile using the PFC2D software developed by Itasca Co. The different scales investigated in these simulations include point and shaft resistance, alterations in porosity and stress fields and particles displacement. Several simulations were conducted in order to investigate the effects of different numerical approaches showing indications that the method of installation and particle rotation could influence greatly in the conditions around the numerical pile. Minor effects were also noted due to change in penetration velocity and pile-soil friction. The difference in behavior of a moving and a stationary pile shows good qualitative agreement with previous experimental results indicating the necessity of realizing a force equilibrium process prior to any load-test to be simulated.

Symmetric and arbitrarily high-order Birkhoff-Hermite time integrators and their long-time behaviour for solving nonlinear Klein-Gordon equations

NASA Astrophysics Data System (ADS)

Liu, Changying; Iserles, Arieh; Wu, Xinyuan

2018-03-01

The Klein-Gordon equation with nonlinear potential occurs in a wide range of application areas in science and engineering. Its computation represents a major challenge. The main theme of this paper is the construction of symmetric and arbitrarily high-order time integrators for the nonlinear Klein-Gordon equation by integrating Birkhoff-Hermite interpolation polynomials. To this end, under the assumption of periodic boundary conditions, we begin with the formulation of the nonlinear Klein-Gordon equation as an abstract second-order ordinary differential equation (ODE) and its operator-variation-of-constants formula. We then derive a symmetric and arbitrarily high-order Birkhoff-Hermite time integration formula for the nonlinear abstract ODE. Accordingly, the stability, convergence and long-time behaviour are rigorously analysed once the spatial differential operator is approximated by an appropriate positive semi-definite matrix, subject to suitable temporal and spatial smoothness. A remarkable characteristic of this new approach is that the requirement of temporal smoothness is reduced compared with the traditional numerical methods for PDEs in the literature. Numerical results demonstrate the advantage and efficiency of our time integrators in comparison with the existing numerical approaches.

Multi-scale sensitivity analysis of pile installation using DEM

NASA Astrophysics Data System (ADS)

Esposito, Ricardo Gurevitz; Velloso, Raquel Quadros; , Eurípedes do Amaral Vargas, Jr.; Danziger, Bernadete Ragoni

2018-07-01

The disturbances experienced by the soil due to the pile installation and dynamic soil-structure interaction still present major challenges to foundation engineers. These phenomena exhibit complex behaviors, difficult to measure in physical tests and to reproduce in numerical models. Due to the simplified approach used by the discrete element method (DEM) to simulate large deformations and nonlinear stress-dilatancy behavior of granular soils, the DEM consists of an excellent tool to investigate these processes. This study presents a sensitivity analysis of the effects of introducing a single pile using the PFC2D software developed by Itasca Co. The different scales investigated in these simulations include point and shaft resistance, alterations in porosity and stress fields and particles displacement. Several simulations were conducted in order to investigate the effects of different numerical approaches showing indications that the method of installation and particle rotation could influence greatly in the conditions around the numerical pile. Minor effects were also noted due to change in penetration velocity and pile-soil friction. The difference in behavior of a moving and a stationary pile shows good qualitative agreement with previous experimental results indicating the necessity of realizing a force equilibrium process prior to any load-test to be simulated.

The use of microtechnology and nanotechnology in fabricating vascularized tissues.

PubMed

Obregón, Raquel; Ramón-Azcón, Javier; Ahadian, Samad; Shiku, Hitoshi; Bae, Hojae; Ramalingam, Murugan; Matsue, Tomokazu

2014-01-01

Tissue engineering (TE) is a multidisciplinary research area that combines medicine, biology, and material science. In recent decades, microtechnology and nanotechnology have also been gradually integrated into this field and have become essential components of TE research. Tissues and complex organs in the body depend on a branched blood vessel system. One of the main objectives for TE researchers is to replicate this vessel system and obtain functional vascularized structures within engineered tissues or organs. With the help of new nanotechnology and microtechnology, significant progress has been made. Achievements include the design of nanoscale-level scaffolds with new functionalities, development of integrated and rapid nanotechnology methods for biofabrication of vascular tissues, discovery of new composite materials to direct differentiation of stem and inducible pluripotent stem cells into the vascular phenotype. Although numerous challenges to replicating vascularized tissue for clinical uses remain, the combination of these new advances has yielded new tools for producing functional vascular tissues in the near future.

Wavefront shaping with disorder-engineered metasurfaces

NASA Astrophysics Data System (ADS)

Jang, Mooseok; Horie, Yu; Shibukawa, Atsushi; Brake, Joshua; Liu, Yan; Kamali, Seyedeh Mahsa; Arbabi, Amir; Ruan, Haowen; Faraon, Andrei; Yang, Changhuei

2018-02-01

Recently, wavefront shaping with disordered media has demonstrated optical manipulation capabilities beyond those of conventional optics, including extended volume, aberration-free focusing and subwavelength focusing. However, translating these capabilities to useful applications has remained challenging as the input-output characteristics of the disordered media (P variables) need to be exhaustively determined via O(P) measurements. Here, we propose a paradigm shift where the disorder is specifically designed so its exact input-output characteristics are known a priori and can be used with only a few alignment steps. We implement this concept with a disorder-engineered metasurface, which exhibits additional unique features for wavefront shaping such as a large optical memory effect range in combination with a wide angular scattering range, excellent stability, and a tailorable angular scattering profile. Using this designed metasurface with wavefront shaping, we demonstrate high numerical aperture (NA > 0.5) focusing and fluorescence imaging with an estimated 2.2 × 108 addressable points in an 8 mm field of view.

Genetic and metabolic engineering for microbial production of poly-γ-glutamic acid.

PubMed

Cao, Mingfeng; Feng, Jun; Sirisansaneeyakul, Sarote; Song, Cunjiang; Chisti, Yusuf

2018-05-28

Poly-γ-glutamic acid (γ-PGA) is a natural biopolymer of glutamic acid. The repeating units of γ-PGA may be derived exclusively from d-glutamic acid, or l-glutamic acid, or both. The monomer units are linked by amide bonds between the α-amino group and the γ-carboxylic acid group. γ-PGA is biodegradable, edible and water-soluble. It has numerous existing and emerging applications in processing of foods, medicines and cosmetics. This review focuses on microbial production of γ-PGA via genetically and metabolically engineered recombinant bacteria. Strategies for improving production of γ-PGA include modification of its biosynthesis pathway, enhancing the production of its precursor (glutamic acid), and preventing loss of the precursor to competing byproducts. These and other strategies are discussed. Heterologous synthesis of γ-PGA in industrial bacterial hosts that do not naturally produce γ-PGA is discussed. Emerging trends and the challenges affecting the production of γ-PGA are reviewed. Copyright © 2018. Published by Elsevier Inc.

Review on the conversion of thermoacoustic power into electricity.

PubMed

Timmer, Michael A G; de Blok, Kees; van der Meer, Theo H

2018-02-01

Thermoacoustic engines convert heat energy into high amplitude acoustic waves and subsequently into electric power. This article provides a review of the four main methods to convert the (thermo)acoustic power into electricity. First, loudspeakers and linear alternators are discussed in a section on electromagnetic devices. This is followed by sections on piezoelectric transducers, magnetohydrodynamic generators, and bidirectional turbines. Each segment provides a literature review of the given technology for the field of thermoacoustics, focusing on possible configurations, operating characteristics, output performance, and analytical and numerical methods to study the devices. This information is used as an input to discuss the performance and feasibility of each method, and to identify challenges that should be overcome for a more successful implementation in thermoacoustic engines. The work is concluded by a comparison of the four technologies, concentrating on the possible areas of application, the conversion efficiency, maximum electrical power output and more generally the suggested focus for future work in the field.

Experiment for validation of fluid-structure interaction models and algorithms.

PubMed

Hessenthaler, A; Gaddum, N R; Holub, O; Sinkus, R; Röhrle, O; Nordsletten, D

2017-09-01

In this paper a fluid-structure interaction (FSI) experiment is presented. The aim of this experiment is to provide a challenging yet easy-to-setup FSI test case that addresses the need for rigorous testing of FSI algorithms and modeling frameworks. Steady-state and periodic steady-state test cases with constant and periodic inflow were established. Focus of the experiment is on biomedical engineering applications with flow being in the laminar regime with Reynolds numbers 1283 and 651. Flow and solid domains were defined using computer-aided design (CAD) tools. The experimental design aimed at providing a straightforward boundary condition definition. Material parameters and mechanical response of a moderately viscous Newtonian fluid and a nonlinear incompressible solid were experimentally determined. A comprehensive data set was acquired by using magnetic resonance imaging to record the interaction between the fluid and the solid, quantifying flow and solid motion. Copyright © 2016 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.

Atomic oxygen erosion considerations for spacecraft materials selection

NASA Technical Reports Server (NTRS)

Whitaker, Ann F.; Kamenetzky, Rachel R.

1993-01-01

The Long Duration Exposure Facility (LDEF) satellite carried 57 experiments that were designed to define the low-Earth orbit (LEO) space environment and to evaluate the impact of this environment on potential engineering materials and material processes. Deployed by the Shuttle Challenger in April of 1984, LDEF made over 32,000 orbits before being retrieved nearly 6 years later by the Shuttle Columbia in January of 1990. The Solar Array Passive LDEF Experiment (SAMPLE) AO171 contained approximately 300 specimens, representing numerous material classes and material processes. AO171 was located on LDEF in position A8 at a yaw of 38.1 degrees from the ram direction and was subjected to an atomic oxygen (AO) fluence of 6.93 x 10(exp 21) atoms/sq cm. LDEF AO171 data, as well as short-term shuttle data, will be discussed in this paper as it applies to engineering design applications of composites, bulk and thin film polymers, glassy ceramics, thermal control paints, and metals subjected to AO erosion.

Design of tissue engineering scaffolds based on hyperbolic surfaces: structural numerical evaluation.

PubMed

Almeida, Henrique A; Bártolo, Paulo J

2014-08-01

Tissue engineering represents a new field aiming at developing biological substitutes to restore, maintain, or improve tissue functions. In this approach, scaffolds provide a temporary mechanical and vascular support for tissue regeneration while tissue in-growth is being formed. These scaffolds must be biocompatible, biodegradable, with appropriate porosity, pore structure and distribution, and optimal vascularization with both surface and structural compatibility. The challenge is to establish a proper balance between porosity and mechanical performance of scaffolds. This work investigates the use of two different types of triple periodic minimal surfaces, Schwarz and Schoen, in order to design better biomimetic scaffolds with high surface-to-volume ratio, high porosity and good mechanical properties. The mechanical behaviour of these structures is assessed through the finite element method software Abaqus. The effect of two parametric parameters (thickness and surface radius) is also evaluated regarding its porosity and mechanical behaviour. Copyright © 2014 IPEM. Published by Elsevier Ltd. All rights reserved.

From grand-canonical density functional theory towards rational compound design

NASA Astrophysics Data System (ADS)

von Lilienfeld, Anatole

2008-03-01

The fundamental challenge of rational compound design, ie the reverse engineering of chemical compounds with predefined specific properties, originates in the high-dimensional combinatorial nature of chemical space. Chemical space is the hyper-space of a given set of molecular observables that is spanned by the grand-canonical variables (particle densities of electrons and nuclei) which define chemical composition. A brief but rigorous description of chemical space within the molecular grand-canonical ensemble multi-component density functional theory framework will be given [1]. Numerical results will be presented for intermolecular energies as a continuous function of alchemical variations within a neutral and isoelectronic 10 proton system, including CH4, NH3, H2O, and HF, interacting with formic acid [2]. Furthermore, engineering the Fermi level through alchemical generation of boron-nitrogen doped mutants of benzene shall be discussed [3].[1] von Lilienfeld and Tuckerman JCP 125 154104 (2006)[2] von Lilienfeld and Tuckerman JCTC 3 1083 (2007)[3] Marcon et al. JCP 127 064305 (2007)

Engineering's Grand Challenges: Priorities and Integration Recommendations for Technology Education Curriculum Development

ERIC Educational Resources Information Center

Buelin, Jennifer; Clark, Aaron C.; Ernst, Jeremy V.

2016-01-01

In this study, the 14 Grand Challenges for Engineering in the 21st Century identified by the National Academy of Engineering were examined by a panel of experts in an effort to identify prospective curricular integration opportunities in the field of technology and engineering education. The study utilized a three-round modified Delphi methodology…

Parallel methodology to capture cyclic variability in motored engines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ameen, Muhsin M.; Yang, Xiaofeng; Kuo, Tang-Wei

2016-07-28

Numerical prediction of of cycle-to-cycle variability (CCV) in SI engines is extremely challenging for two key reasons: (i) high-fidelity methods such as large eddy simulation (LES) are require to accurately capture the in-cylinder turbulent flowfield, and (ii) CCV is experienced over long timescales and hence the simulations need to be performed for hundreds of consecutive cycles. In this study, a new methodology is proposed to dissociate this long time-scale problem into several shorter time-scale problems, which can considerably reduce the computational time without sacrificing the fidelity of the simulations. The strategy is to perform multiple single-cycle simulations in parallel bymore » effectively perturbing the simulation parameters such as the initial and boundary conditions. It is shown that by perturbing the initial velocity field effectively based on the intensity of the in-cylinder turbulence, the mean and variance of the in-cylinder flowfield is captured reasonably well. Adding perturbations in the initial pressure field and the boundary pressure improves the predictions. It is shown that this new approach is able to give accurate predictions of the flowfield statistics in less than one-tenth of time required for the conventional approach of simulating consecutive engine cycles.« less

Surrogate species selection for assessing potential adverse environmental impacts of genetically engineered insect-resistant plants on non-target organisms.

PubMed

Carstens, Keri; Cayabyab, Bonifacio; De Schrijver, Adinda; Gadaleta, Patricia G; Hellmich, Richard L; Romeis, Jörg; Storer, Nicholas; Valicente, Fernando H; Wach, Michael

2014-01-01

Most regulatory authorities require that developers of genetically engineered insect-resistant (GEIR) crops evaluate the potential for these crops to have adverse impacts on valued non-target organisms (NTOs), i.e., organisms not intended to be controlled by the trait. In many cases, impacts to NTOs are assessed using surrogate species, and it is critical that the data derived from surrogates accurately predict any adverse impacts likely to be observed from the use of the crop in the agricultural context. The key is to select surrogate species that best represent the valued NTOs in the location where the crop is going to be introduced, but this selection process poses numerous challenges for the developers of GE crops who will perform the tests, as well as for the ecologists and regulators who will interpret the test results. These issues were the subject of a conference "Surrogate Species Selection for Assessing Potential Adverse Environmental Impacts of Genetically Engineered Plants on Non-Target Organisms" convened by the Center for Environmental Risk Assessment, ILSI Research Foundation. This report summarizes the proceedings of the conference, including the presentations, discussions and the points of consensus agreed to by the participants.

Object Based Numerical Zooming Between the NPSS Version 1 and a 1-Dimensional Meanline High Pressure Compressor Design Analysis Code

NASA Technical Reports Server (NTRS)

Follen, G.; Naiman, C.; auBuchon, M.

2000-01-01

Within NASA's High Performance Computing and Communication (HPCC) program, NASA Glenn Research Center is developing an environment for the analysis/design of propulsion systems for aircraft and space vehicles called the Numerical Propulsion System Simulation (NPSS). The NPSS focuses on the integration of multiple disciplines such as aerodynamics, structures, and heat transfer, along with the concept of numerical zooming between 0- Dimensional to 1-, 2-, and 3-dimensional component engine codes. The vision for NPSS is to create a "numerical test cell" enabling full engine simulations overnight on cost-effective computing platforms. Current "state-of-the-art" engine simulations are 0-dimensional in that there is there is no axial, radial or circumferential resolution within a given component (e.g. a compressor or turbine has no internal station designations). In these 0-dimensional cycle simulations the individual component performance characteristics typically come from a table look-up (map) with adjustments for off-design effects such as variable geometry, Reynolds effects, and clearances. Zooming one or more of the engine components to a higher order, physics-based analysis means a higher order code is executed and the results from this analysis are used to adjust the 0-dimensional component performance characteristics within the system simulation. By drawing on the results from more predictive, physics based higher order analysis codes, "cycle" simulations are refined to closely model and predict the complex physical processes inherent to engines. As part of the overall development of the NPSS, NASA and industry began the process of defining and implementing an object class structure that enables Numerical Zooming between the NPSS Version I (0-dimension) and higher order 1-, 2- and 3-dimensional analysis codes. The NPSS Version I preserves the historical cycle engineering practices but also extends these classical practices into the area of numerical zooming for use within a companies' design system. What follows here is a description of successfully zooming I-dimensional (row-by-row) high pressure compressor results back to a NPSS engine 0-dimension simulation and a discussion of the results illustrated using an advanced data visualization tool. This type of high fidelity system-level analysis, made possible by the zooming capability of the NPSS, will greatly improve the fidelity of the engine system simulation and enable the engine system to be "pre-validated" prior to commitment to engine hardware.

Bend-Twist Coupled Carbon-Fiber Laminate Beams: Fundamental Behavior and Applications

NASA Astrophysics Data System (ADS)

Babuska, Pavel

Material-induced bend-twist coupling in laminated composite beams has seen applications in engineered structures for decades, ranging from airplane wings to turbine blades. Symmetric, unbalanced, carbon fiber laminates which exhibit bend-twist coupling can be difficult to characterize and exhibit unintuitive deformation states which may pose challenges to the engineer. In this thesis, bend-twist coupled beams are investigated comprehensively, by experimentation, numerical modeling, and analytical methods. Beams of varying fiber angle and amount of coupling were manufactured and physically tested in both linear and nonlinear static and dynamic settings. Analytical mass and stiffness matrices were derived for the development of a beam element to use in the stiffness matrix analysis method. Additionally, an ABAQUS finite element model was used in conjunction with the analytical methods to predict and further characterize the behavior of the beams. The three regimes, experimental, analytical, and numerical, represent a full-field characterization of bend-twist coupling in composite beams. A notable application of bend-twist coupled composites is for passively adaptive turbine blades whereby the deformation coupling can be built into the blade structure to simultaneously bend and twist, thus pitching the blade into or away from the fluid flow, changing the blade angle of attack. Passive pitch adaptation has been implemented successfully in wind turbine blades, however, for marine turbine blades, the technology is still in the development phase. Bend-twist coupling has been shown numerically to be beneficial to the tidal turbine performance, however little validation has been conducted in the experimental regime. In this thesis, passively adaptive experiment scale tidal turbine blades were designed, analyzed, manufactured, and physically tested, validating the foundational numerical work. It was shown that blade forces and root moments as well as turbine thrust and power coefficients can be manipulated by inclusion of passive pitch adaption by bend-twist coupling.

Analytical and Numerical Solutions of Generalized Fokker-Planck Equations - Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prinja, Anil K.

The overall goal of this project was to develop advanced theoretical and numerical techniques to quantitatively describe the spreading of a collimated beam of charged particles in space, in angle, and in energy, as a result of small deflection, small energy transfer Coulomb collisions with the target nuclei and electrons. Such beams arise in several applications of great interest in nuclear engineering, and include electron and ion radiotherapy, ion beam modification of materials, accelerator transmutation of waste, and accelerator production of tritium, to name some important candidates. These applications present unique and difficult modeling challenges, but from the outset aremore » amenable to the language of ''transport theory'', which is very familiar to nuclear engineers and considerably less-so to physicists and material scientists. Thus, our approach has been to adopt a fundamental description based on transport equations, but the forward peakedness associated with charged particle interactions precludes a direct application of solution methods developed for neutral particle transport. Unique problem formulations and solution techniques are necessary to describe the transport and interaction of charged particles. In particular, we have developed the Generalized Fokker-Planck (GFP) approach to describe the angular and radial spreading of a collimated beam and a renormalized transport model to describe the energy-loss straggling of an initially monoenergetic distribution. Both analytic and numerical solutions have been investigated and in particular novel finite element numerical methods have been developed. In the first phase of the project, asymptotic methods were used to develop closed form solutions to the GFP equation for different orders of expansion, and was described in a previous progress report. In this final report we present a detailed description of (i) a novel energy straggling model based on a Fokker-Planck approximation but which is adapted for a multigroup transport setting, and (ii) two unique families of discontinuous finite element schemes, one linear and the other nonlinear.« less

A review of active control approaches in stabilizing combustion systems in aerospace industry

NASA Astrophysics Data System (ADS)

Zhao, Dan; Lu, Zhengli; Zhao, He; Li, X. Y.; Wang, Bing; Liu, Peijin

2018-02-01

Self-sustained combustion instabilities are one of the most plaguing challenges and problems in lean-conditioned propulsion and land-based engine systems, such as rocket motors, gas turbines, industrial furnace and boilers, and turbo-jet thrust augmenters. Either passive or active control in open- or closed-loop configurations can be implemented to mitigate such instabilities. One of the classical disadvantages of passive control is that it is only implementable to a designed combustor over a limited frequency range and can not respond to the changes in operating conditions. Compared with passive control approaches, active control, especially in closed-loop configuration is more adaptive and has inherent capacity to be implemented in practice. The key components in closed-loop active control are 1) sensor, 2) controller (optimization algorithm) and 3) dynamic actuator. The present work is to outline the current status, technical challenges and development progress of the active control approaches (in open- or closed-loop configurations). A brief description of feedback control, adaptive control, model-based control and sliding mode control are provided first by introducing a simplified Rijke-type combustion system. The modelled combustion system provides an invaluable platform to evaluate the performance of these feedback controllers and a transient growth controller. The performance of these controllers are compared and discussed. An outline of theoretical, numerical and experimental investigations are then provided to overview the research and development progress made during the last 4 decades. Finally, potential, challenges and issues involved with the design, application and implementation of active combustion control strategies on a practical engine system are highlighted.

Numerical Modeling of Pulse Detonation Rocket Engine Gasdynamics and Performance

NASA Technical Reports Server (NTRS)

2003-01-01

This paper presents viewgraphs on the numerical modeling of pulse detonation rocket engines (PDRE), with an emphasis on the Gasdynamics and performance analysis of these engines. The topics include: 1) Performance Analysis of PDREs; 2) Simplified PDRE Cycle; 3) Comparison of PDRE and Steady-State Rocket Engines (SSRE) Performance; 4) Numerical Modeling of Quasi 1-D Rocket Flows; 5) Specific PDRE Geometries Studied; 6) Time-Accurate Thrust Calculations; 7) PDRE Performance (Geometries A B C and D); 8) PDRE Blowdown Gasdynamics (Geom. A B C and D); 9) PDRE Geometry Performance Comparison; 10) PDRE Blowdown Time (Geom. A B C and D); 11) Specific SSRE Geometry Studied; 12) Effect of F-R Chemistry on SSRE Performance; 13) PDRE/SSRE Performance Comparison; 14) PDRE Performance Study; 15) Grid Resolution Study; and 16) Effect of F-R Chemistry on SSRE Exit Species Mole Fractions.

The coupling of engines

NASA Technical Reports Server (NTRS)

Boccaccio, Paul

1921-01-01

This report examines the idea of coupling numerous engines together to turn a single propeller, which the author feels would free aircraft design from the problems of multi-engine and propeller design.

Addressing the Grand Challenge of atmospheric carbon dioxide: geologic sequestration vs. biological recycling

PubMed Central

2011-01-01

On February 15, 2008, the National Academy of Engineering unveiled their list of 14 Grand Challenges for Engineering. Building off of tremendous advancements in the past century, these challenges were selected for their role in assuring a sustainable existence for the rapidly increasing global community. It is no accident that the first five Challenges on the list involve the development of sustainable energy sources and management of environmental resources. While the focus of this review is to address the single Grand Challenge of "develop carbon sequestration methods", is will soon be clear that several other Challenges are intrinsically tied to it through the principles of sustainability. How does the realm of biological engineering play a role in addressing these Grand Challenges? PMID:22047501

New Challenging Approaches to Engineering Education: Enhancing University-Industry Co-Operation

ERIC Educational Resources Information Center

Korhonen-Yrjanheikki, Kati; Tukiainen, Taina; Takala, Minna

2007-01-01

Globalization, accelerated time-based competition, qualitative dynamics, rapid development of technology and especially Information and Communications Technology (ICT) developments challenge engineering education and capability development of each engineer. The success and the competitiveness of companies are increasingly based on their employees.…

Biocatalysis engineering: the big picture.

PubMed

Sheldon, Roger A; Pereira, Pedro C

2017-05-22

In this tutorial review we describe a holistic approach to the invention, development and optimisation of biotransformations utilising isolated enzymes. Increasing attention to applied biocatalysis is motivated by its numerous economic and environmental benefits. Biocatalysis engineering concerns the development of enzymatic systems as a whole, which entails engineering its different components: substrate engineering, medium engineering, protein (enzyme) engineering, biocatalyst (formulation) engineering, biocatalytic cascade engineering and reactor engineering.

NPSS on NASA's IPG: Using CORBA and Globus to Coordinate Multidisciplinary Aeroscience Applications

NASA Technical Reports Server (NTRS)

Lopez, Isaac; Follen, Gregory J.; Gutierrez, Richard; Naiman, Cynthia G.; Foster, Ian; Ginsburg, Brian; Larsson, Olle; Martin, Stuart; Tuecke, Steven; Woodford, David

2000-01-01

Within NASA's High Performance Computing and Communication (HPCC) program, the NASA Glenn Research Center is developing an environment for the analysis/design of aircraft engines called the Numerical Propulsion System Simulation (NPSS). The vision for NPSS is to create a "numerical test cell" enabling full engine simulations overnight on cost-effective computing platforms. To this end, NPSS integrates multiple disciplines such as aerodynamics, structures, and heat transfer and supports "numerical zooming" between O-dimensional to 1-, 2-, and 3-dimensional component engine codes. In order to facilitate the timely and cost-effective capture of complex physical processes, NPSS uses object-oriented technologies such as C++ objects to encapsulate individual engine components and CORBA ORBs for object communication and deployment across heterogeneous computing platforms. Recently, the HPCC program has initiated a concept called the Information Power Grid (IPG), a virtual computing environment that integrates computers and other resources at different sites. IPG implements a range of Grid services such as resource discovery, scheduling, security, instrumentation, and data access, many of which are provided by the Globus toolkit. IPG facilities have the potential to benefit NPSS considerably. For example, NPSS should in principle be able to use Grid services to discover dynamically and then co-schedule the resources required for a particular engine simulation, rather than relying on manual placement of ORBs as at present. Grid services can also be used to initiate simulation components on parallel computers (MPPs) and to address inter-site security issues that currently hinder the coupling of components across multiple sites. These considerations led NASA Glenn and Globus project personnel to formulate a collaborative project designed to evaluate whether and how benefits such as those just listed can be achieved in practice. This project involves firstly development of the basic techniques required to achieve co-existence of commodity object technologies and Grid technologies; and secondly the evaluation of these techniques in the context of NPSS-oriented challenge problems. The work on basic techniques seeks to understand how "commodity" technologies (CORBA, DCOM, Excel, etc.) can be used in concert with specialized "Grid" technologies (for security, MPP scheduling, etc.). In principle, this coordinated use should be straightforward because of the Globus and IPG philosophy of providing low-level Grid mechanisms that can be used to implement a wide variety of application-level programming models. (Globus technologies have previously been used to implement Grid-enabled message-passing libraries, collaborative environments, and parameter study tools, among others.) Results obtained to date are encouraging: we have successfully demonstrated a CORBA to Globus resource manager gateway that allows the use of CORBA RPCs to control submission and execution of programs on workstations and MPPs; a gateway from the CORBA Trader service to the Grid information service; and a preliminary integration of CORBA and Grid security mechanisms. The two challenge problems that we consider are the following: 1) Desktop-controlled parameter study. Here, an Excel spreadsheet is used to define and control a CFD parameter study, via a CORBA interface to a high throughput broker that runs individual cases on different IPG resources. 2) Aviation safety. Here, about 100 near real time jobs running NPSS need to be submitted, run and data returned in near real time. Evaluation will address such issues as time to port, execution time, potential scalability of simulation, and reliability of resources. The full paper will present the following information: 1. A detailed analysis of the requirements that NPSS applications place on IPG. 2. A description of the techniques used to meet these requirements via the coordinated use of CORBA and Globus. 3. A description of results obtained to date in the first two challenge problems.

Reflections of a Faraday Challenge Day Leader

ERIC Educational Resources Information Center

Sewell, Keira

2014-01-01

Keira Sewell has just finished her second year as a Challenge Leader for the Faraday Challenge, a STEM-based scheme run by the Institution of Engineering and Technology. Aimed at 12-13 year-old students, its purpose is to engage students in future careers in engineering. Each year, a new challenge is held in over sixty schools and universities…

Engineering craniofacial structures: facing the challenge.

PubMed

Zaky, S H; Cancedda, R

2009-12-01

The human innate regenerative ability is known to be limited by the intensity of the insult together with the availability of progenitor cells, which may cause certain irreparable damage. It is only recently that the paradigm of tissue engineering found its way to the treatment of irreversibly affected body structures with the challenge of reconstructing the lost part. In the current review, we underline recent trials that target engineering of human craniofacial structures, mainly bone, cartilage, and teeth. We analyze the applied engineering strategies relative to the selection of cell types to lay down a specific targeted tissue, together with their association with an escorting scaffold for a particular engineered site, and discuss their necessity to be sustained by growth factors. Challenges and expectations for facial skeletal engineering are discussed in the context of future treatment.

Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room.

PubMed

Cengiz, Ibrahim Fatih; Pereira, Hélder; de Girolamo, Laura; Cucchiarini, Magali; Espregueira-Mendes, João; Reis, Rui L; Oliveira, Joaquim Miguel

2018-05-22

Orthopaedic disorders are very frequent, globally found and often partially unresolved despite the substantial advances in science and medicine. Their surgical intervention is multifarious and the most favourable treatment is chosen by the orthopaedic surgeon on a case-by-case basis depending on a number of factors related with the patient and the lesion. Numerous regenerative tissue engineering strategies have been developed and studied extensively in laboratory through in vitro experiments and preclinical in vivo trials with various established animal models, while a small proportion of them reached the operating room. However, based on the available literature, the current strategies have not yet achieved to fully solve the clinical problems. Thus, the gold standards, if existing, remain unchanged in the clinics, notwithstanding the known limitations and drawbacks. Herein, the involvement of regenerative tissue engineering in the clinical orthopaedics is reviewed. The current challenges are indicated and discussed in order to describe the current disequilibrium between the needs and solutions made available in the operating room. Regenerative tissue engineering is a very dynamic field that has a high growth rate and a great openness and ability to incorporate new technologies with passion to edge towards the Holy Grail that is functional tissue regeneration. Thus, the future of clinical solutions making use of regenerative tissue engineering principles for the management of orthopaedic disorders is firmly supported by the clinical need.

Re-Engineering Complex Legacy Systems at NASA

NASA Technical Reports Server (NTRS)

Ruszkowski, James; Meshkat, Leila

2010-01-01

The Flight Production Process (FPP) Re-engineering project has established a Model-Based Systems Engineering (MBSE) methodology and the technological infrastructure for the design and development of a reference, product-line architecture as well as an integrated workflow model for the Mission Operations System (MOS) for human space exploration missions at NASA Johnson Space Center. The design and architectural artifacts have been developed based on the expertise and knowledge of numerous Subject Matter Experts (SMEs). The technological infrastructure developed by the FPP Re-engineering project has enabled the structured collection and integration of this knowledge and further provides simulation and analysis capabilities for optimization purposes. A key strength of this strategy has been the judicious combination of COTS products with custom coding. The lean management approach that has led to the success of this project is based on having a strong vision for the whole lifecycle of the project and its progress over time, a goal-based design and development approach, a small team of highly specialized people in areas that are critical to the project, and an interactive approach for infusing new technologies into existing processes. This project, which has had a relatively small amount of funding, is on the cutting edge with respect to the utilization of model-based design and systems engineering. An overarching challenge that was overcome by this project was to convince upper management of the needs and merits of giving up more conventional design methodologies (such as paper-based documents and unwieldy and unstructured flow diagrams and schedules) in favor of advanced model-based systems engineering approaches.

The Radical Flank Effect and Cross-occupational Collaboration for Technology Development during a Power Shift.

PubMed

Truelove, Emily; Kellogg, Katherine C

2016-12-01

This 12-month ethnographic study of an early entrant into the U.S. car-sharing industry demonstrates that when an organization shifts its focus from developing radical new technology to incrementally improving this technology, the shift may spark an internal power struggle between the dominant engineering group and a challenger occupational group such as the marketing group. Analyzing 42 projects in two time periods that required collaboration between engineering and marketing during such a shift, we show how cross-occupational collaboration under these conditions can be facilitated by a radical flank threat, through which the bargaining power of moderates is strengthened by the presence of a more-radical group. In the face of a strong threat by radical members of a challenger occupational group, moderate members of the dominant engineering group may change their perceptions of their power to resist challengers' demands and begin to distinguish between the goals of radical versus more-moderate challengers. To maintain as much power as possible and prevent the more-dramatic change in engineering occupational goals demanded by radical challengers, moderate engineers may build a coalition with moderate challengers and collaborate for incremental technology development.

Education and research in fluid dynamics

NASA Astrophysics Data System (ADS)

López González-Nieto, P.; Redondo, J. M.; Cano, J. L.

2009-04-01

Fluid dynamics constitutes an essential subject for engineering, since auronautic engineers (airship flights in PBL, flight processes), industrial engineers (fluid transportation), naval engineers (ship/vessel building) up to agricultural engineers (influence of the weather conditions on crops/farming). All the above-mentioned examples possess a high social and economic impact on mankind. Therefore, the fluid dynamics education of engineers is very important, and, at the same time, this subject gives us an interesting methodology based on a cycle relation among theory, experiments and numerical simulation. The study of turbulent plumes -a very important convective flow- is a good example because their theoretical governing equations are simple; it is possible to make experimental plumes in an aesy way and to carry out the corresponding numerical simulatons to verify experimental and theoretical results. Moreover, it is possible to get all these aims in the educational system (engineering schools or institutions) using a basic laboratory and the "Modellus" software.

Prediction of high frequency combustion instability in liquid propellant rocket engines

NASA Technical Reports Server (NTRS)

Kim, Y. M.; Chen, C. P.; Ziebarth, J. P.; Chen, Y. S.

1992-01-01

The present use of a numerical model developed for the prediction of high-frequency combustion stabilities in liquid propellant rocket engines focuses on (1) the overall behavior of nonlinear combustion instabilities (2) the effects of acoustic oscillations on the fuel-droplet vaporization and combustion process in stable and unstable engine operating conditions, oscillating flowfields, and liquid-fuel trajectories during combustion instability, and (3) the effects of such design parameters as inlet boundary conditions, initial spray conditions, and baffle length. The numerical model has yielded predictions of the tangential-mode combustion instability; baffle length and droplet size variations are noted to have significant effects on engine stability.

Numerical Modeling of Pulse Detonation Rocket Engine Gasdynamics and Performance

NASA Technical Reports Server (NTRS)

Morris, C. I.

2003-01-01

Pulse detonation engines (PDB) have generated considerable research interest in recent years as a chemical propulsion system potentially offering improved performance and reduced complexity compared to conventional gas turbines and rocket engines. The detonative mode of combustion employed by these devices offers a theoretical thermodynamic advantage over the constant-pressure deflagrative combustion mode used in conventional engines. However, the unsteady blowdown process intrinsic to all pulse detonation devices has made realistic estimates of the actual propulsive performance of PDES problematic. The recent review article by Kailasanath highlights some of the progress that has been made in comparing the available experimental measurements with analytical and numerical models.

Numerical study of a scramjet engine flow field

NASA Technical Reports Server (NTRS)

Drummond, J. P.; Weidner, E. H.

1981-01-01

A computer program has been developed to analyze the turbulent reacting flow field in a two-dimensional scramjet engine configuration. The program numerically solves the full two-dimensional Navier-Stokes and species equations in the engine inlet and combustor, allowing consideration of flow separation and possible inlet-combustor interactions. The current work represents an intermediate step towards development of a three-dimensional program to analyze actual scramjet engine flow fields. Results from the current program are presented that predict the flow field for two inlet-combustor configurations, and comparisons of the program with experiment are given to allow assessment of the modeling that is employed.

Biodegradable Polyphosphazene-Based Blends for Regenerative Engineering

PubMed Central

Ogueri, Kenneth S.; Escobar Ivirico, Jorge L.; Nair, Lakshmi S.; Allcock, Harry R.; Laurencin, Cato T.

2017-01-01

The occurrence of musculoskeletal tissue injury or disease and the subsequent functional impairment is at an alarming rate. It continues to be one of the most challenging problems in the human health care. Regenerative engineering offers a promising transdisciplinary strategy for tissues regeneration based on the convergence of tissue engineering, advanced materials science, stem cell science, developmental biology and clinical translation. Biomaterials are emerging as extracellular-mimicking matrices designed to provide instructive cues to control cell behavior and ultimately, be applied as therapies to regenerate damaged tissues. Biodegradable polymers constitute an attractive class of biomaterials for the development of scaffolds due to their flexibility in chemistry and the ability to be excreted or resorbed by the body. Herein, the focus will be on biodegradable polyphosphazene-based blend systems. The synthetic flexibility of polyphosphazene, combined with the unique inorganic backbone, has provided a springboard for more research and subsequent development of numerous novel materials that are capable of forming miscible blends with poly (lactide-co-glycolide) (PLAGA). Laurencin and co-workers has demonstrated the exploitation of the synthetic flexibility of Polyphosphazene that will allow the design of novel polymers, which can form miscible blends with PLAGA for biomedical applications. These novel blends, due to their well-tuned biodegradability, and mechanical and biological properties coupled with the buffering capacity of the degradation products, constitute ideal materials for regeneration of various musculoskeletal tissues. Lay Summary Regenerative engineering aims to regenerate complex tissues to address the clinical challenge of organ damage. Tissue engineering has largely focused on the restoration and repair of individual tissues and organs, but over the past 25 years, scientific, engineering, and medical advances have led to the introduction of this new approach which involves the regeneration of complex tissues and biological systems such as a knee or a whole limb. While a number of excellent advanced biomaterials have been developed, the choice of biomaterials, however, has increased over the past years to include polymers that can be designed with a range of mechanical properties, degradation rates, and chemical functionality. The polyphosphazenes are one good example. Their chemical versatility and hydrogen bonding capability encourages blending with other biologically relevant polymers. The further development of Polyphosphazene-based blends will present a wide spectrum of advanced biomaterials that can be used as scaffolds for regenerative engineering and as well as other biomedical applications. PMID:28596987

Biodegradable Polyphosphazene-Based Blends for Regenerative Engineering.

PubMed

Ogueri, Kenneth S; Escobar Ivirico, Jorge L; Nair, Lakshmi S; Allcock, Harry R; Laurencin, Cato T

2017-03-01

The occurrence of musculoskeletal tissue injury or disease and the subsequent functional impairment is at an alarming rate. It continues to be one of the most challenging problems in the human health care. Regenerative engineering offers a promising transdisciplinary strategy for tissues regeneration based on the convergence of tissue engineering, advanced materials science, stem cell science, developmental biology and clinical translation. Biomaterials are emerging as extracellular-mimicking matrices designed to provide instructive cues to control cell behavior and ultimately, be applied as therapies to regenerate damaged tissues. Biodegradable polymers constitute an attractive class of biomaterials for the development of scaffolds due to their flexibility in chemistry and the ability to be excreted or resorbed by the body. Herein, the focus will be on biodegradable polyphosphazene-based blend systems. The synthetic flexibility of polyphosphazene, combined with the unique inorganic backbone, has provided a springboard for more research and subsequent development of numerous novel materials that are capable of forming miscible blends with poly (lactide-co-glycolide) (PLAGA). Laurencin and co-workers has demonstrated the exploitation of the synthetic flexibility of Polyphosphazene that will allow the design of novel polymers, which can form miscible blends with PLAGA for biomedical applications. These novel blends, due to their well-tuned biodegradability, and mechanical and biological properties coupled with the buffering capacity of the degradation products, constitute ideal materials for regeneration of various musculoskeletal tissues. Regenerative engineering aims to regenerate complex tissues to address the clinical challenge of organ damage. Tissue engineering has largely focused on the restoration and repair of individual tissues and organs, but over the past 25 years, scientific, engineering, and medical advances have led to the introduction of this new approach which involves the regeneration of complex tissues and biological systems such as a knee or a whole limb. While a number of excellent advanced biomaterials have been developed, the choice of biomaterials, however, has increased over the past years to include polymers that can be designed with a range of mechanical properties, degradation rates, and chemical functionality. The polyphosphazenes are one good example. Their chemical versatility and hydrogen bonding capability encourages blending with other biologically relevant polymers. The further development of Polyphosphazene-based blends will present a wide spectrum of advanced biomaterials that can be used as scaffolds for regenerative engineering and as well as other biomedical applications.

Engineering Education and Students' Challenges: Strategies toward Enhancing the Educational Environment in Engineering Colleges

ERIC Educational Resources Information Center

Alkandari, Nabila Y.

2014-01-01

The main goal of this research is to gain an understanding of the challenges which have to be confronted by the engineering students at the College of Engineering and Petroleum at Kuwait University. The college has a large number of students, of which three hundred and eighty five were selected on a random basis for study purposes. The results…

Socio-Cultural Challenges in Global Software Engineering Education

ERIC Educational Resources Information Center

Hoda, Rashina; Babar, Muhammad Ali; Shastri, Yogeshwar; Yaqoob, Humaa

2017-01-01

Global software engineering education (GSEE) is aimed at providing software engineering (SE) students with knowledge, skills, and understanding of working in globally distributed arrangements so they can be prepared for the global SE (GSE) paradigm. It is important to understand the challenges involved in GSEE for improving the quality and…

Implementing Inclusive Engineering Challenges for Elementary Students

ERIC Educational Resources Information Center

Silva Mangiante, Elaine; Moore, Adam

2015-01-01

The Next Generation Science Standards emphasize the need to promote equitable opportunities for all students to engage in science and engineering. This article offers eight tips that educators can use to support students of all abilities, including those with special learning needs, to engage in engineering challenges at the elementary level.

Why Research-Informed Teaching in Engineering Education? A Review of the Evidence

ERIC Educational Resources Information Center

Bubou, Gordon Monday; Offor, Ibebietei Temple; Bappa, Abubakar Saddiq

2017-01-01

Challenges of today's engineering education (EE) are emergent, necessitating calls for its reformation to empower future engineers function optimally as innovative leaders, in both local and international contexts. These challenges: keeping pace with technological dynamism; high attrition; and most importantly, quality teaching/learning require…

Fungal biology and agriculture: revisiting the field

USGS Publications Warehouse

Yarden, O.; Ebbole, D.J.; Freeman, S.; Rodriguez, R.J.; Dickman, M. B.

2003-01-01

Plant pathology has made significant progress over the years, a process that involved overcoming a variety of conceptual and technological hurdles. Descriptive mycology and the advent of chemical plant-disease management have been followed by biochemical and physiological studies of fungi and their hosts. The later establishment of biochemical genetics along with the introduction of DNA-mediated transformation have set the stage for dissection of gene function and advances in our understanding of fungal cell biology and plant-fungus interactions. Currently, with the advent of high-throughput technologies, we have the capacity to acquire vast data sets that have direct relevance to the numerous subdisciplines within fungal biology and pathology. These data provide unique opportunities for basic research and for engineering solutions to important agricultural problems. However, we also are faced with the challenge of data organization and mining to analyze the relationships between fungal and plant genomes and to elucidate the physiological function of pertinent DNA sequences. We present our perspective of fungal biology and agriculture, including administrative and political challenges to plant protection research.

Marshall Team Fires Recreated Goddard Rocket

NASA Technical Reports Server (NTRS)

2003-01-01

In honor of the Centernial of Flight Celebration and commissioned by the American Institute of Aeronautics and Astronautics (AIAA), a team of engineers from Marshall Space Flight Center (MSFC) built a replica of the first liquid-fueled rocket. The original rocket, designed and built by rocket engineering pioneer Robert H. Goddard in 1926, opened the door to modern rocketry. Goddard's rocket reached an altitude of 41 feet while its flight lasted only 2.5 seconds. The Marshall design team's plan was to stay as close as possible to an authentic reconstruction of Goddard's rocket. The same propellants were used - liquid oxygen and gasoline - as available during Goddard's initial testing and firing. The team also tried to construct the replica using the original materials and design to the greatest extent possible. By purposely using less advanced techniques and materials than many that are available today, the team encountered numerous technical challenges in testing the functional hardware. There were no original blueprints or drawings, only photographs and notes. However, this faithful adherence to historical accuracy has allowed the team to experience many of the same challenges Goddard faced 77 years ago, and more fully appreciate the genius of this extraordinary man. In this photo, the replica is shown firing in the A-frame launch stand in near-flight configuration at MSFC's Test Area 116 during the American Institute of Aeronautics and Astronautics 39th Joint Propulsion Conference on July 23, 2003.

Around Marshall

NASA Image and Video Library

2003-07-23

In honor of the Centernial of Flight Celebration and commissioned by the American Institute of Aeronautics and Astronautics (AIAA), a team of engineers from Marshall Space Flight Center (MSFC) built a replica of the first liquid-fueled rocket. The original rocket, designed and built by rocket engineering pioneer Robert H. Goddard in 1926, opened the door to modern rocketry. Goddard's rocket reached an altitude of 41 feet while its flight lasted only 2.5 seconds. The Marshall design team's plan was to stay as close as possible to an authentic reconstruction of Goddard's rocket. The same propellants were used - liquid oxygen and gasoline - as available during Goddard's initial testing and firing. The team also tried to construct the replica using the original materials and design to the greatest extent possible. By purposely using less advanced techniques and materials than many that are available today, the team encountered numerous technical challenges in testing the functional hardware. There were no original blueprints or drawings, only photographs and notes. However, this faithful adherence to historical accuracy has allowed the team to experience many of the same challenges Goddard faced 77 years ago, and more fully appreciate the genius of this extraordinary man. In this photo, the replica is shown firing in the A-frame launch stand in near-flight configuration at MSFC's Test Area 116 during the American Institute of Aeronautics and Astronautics 39th Joint Propulsion Conference on July 23, 2003.

Ocular surface reconstruction with a tissue-engineered nasal mucosal epithelial cell sheet for the treatment of severe ocular surface diseases.

PubMed

Kobayashi, Masakazu; Nakamura, Takahiro; Yasuda, Makoto; Hata, Yuiko; Okura, Shoki; Iwamoto, Miyu; Nagata, Maho; Fullwood, Nigel J; Koizumi, Noriko; Hisa, Yasuo; Kinoshita, Shigeru

2015-01-01

Severe ocular surface diseases (OSDs) with severe dry eye can be devastating and are currently some of the most challenging eye disorders to treat. To investigate the feasibility of using an autologous tissue-engineered cultivated nasal mucosal epithelial cell sheet (CNMES) for ocular surface reconstruction, we developed a novel technique for the culture of nasal mucosal epithelial cells expanded ex vivo from biopsy-derived human nasal mucosal tissues. After the protocol, the CNMESs had 4-5 layers of stratified, well-differentiated cells, and we successfully generated cultured epithelial sheets, including numerous goblet cells. Immunohistochemistry confirmed the presence of keratins 3, 4, and 13; mucins 1, 16, and 5AC; cell junction and basement membrane assembly proteins; and stem/progenitor cell marker p75 in the CNMESs. We then transplanted the CNMESs onto the ocular surfaces of rabbits and confirmed the survival of this tissue, including the goblet cells, up to 2 weeks. The present report describes an attempt to overcome the problems of treating severe OSDs with the most severe dry eye by treating them using tissue-engineered CNMESs to supply functional goblet cells and to stabilize and reconstruct the ocular surface. The present study is a first step toward assessing the use of tissue-engineered goblet-cell transplantation of nonocular surface origin for ocular surface reconstruction. ©AlphaMed Press.

New Mass Properties Engineers Aerospace Ballasting Challenge Facilitated by the SAWE Community

NASA Technical Reports Server (NTRS)

Cutright, Amanda; Shaughnessy, Brendan

2010-01-01

The discipline of Mass Properties Engineering tends to find the engineers; not typically vice versa. In this case, two engineers quickly found their new responsibilities deep in many aspects of mass properties engineering and required to meet technical challenges in a fast paced environment. As part of NASA's Constellation Program, a series of flight tests will be conducted to evaluate components of the new spacecraft launch vehicles. One of these tests is the Pad Abort 1 (PA-1) flight test which will test the Launch Abort System (LAS), a system designed to provide escape for astronauts in the event of an emergency. The Flight Test Articles (FTA) used in this flight test are required to match mass properties corresponding to the operational vehicle, which has a continually evolving design. Additionally, since the structure and subsystems for the Orion Crew Module (CM) FTA are simplified versions of the final product, thousands of pounds of ballast are necessary to achieve the desired mass properties. These new mass properties engineers are responsible for many mass properties aspects in support of the flight test, including meeting the ballasting challenge for the CM Boilerplate FTA. SAWE expert and experienced mass properties engineers, both those that are directly on the team and many that supported via a variety of Society venues, significantly contributed to facilitating the success of addressing this particular mass properties ballasting challenge, in addition to many other challenges along the way. This paper discusses the details regarding the technical aspects of this particular mass properties challenge, as well as identifies recommendations for new mass properties engineers that were learned from the SAWE community along the way.

High Speed Dynamics in Brittle Materials

NASA Astrophysics Data System (ADS)

Hiermaier, Stefan

2015-06-01

Brittle Materials under High Speed and Shock loading provide a continuous challenge in experimental physics, analysis and numerical modelling, and consequently for engineering design. The dependence of damage and fracture processes on material-inherent length and time scales, the influence of defects, rate-dependent material properties and inertia effects on different scales make their understanding a true multi-scale problem. In addition, it is not uncommon that materials show a transition from ductile to brittle behavior when the loading rate is increased. A particular case is spallation, a brittle tensile failure induced by the interaction of stress waves leading to a sudden change from compressive to tensile loading states that can be invoked in various materials. This contribution highlights typical phenomena occurring when brittle materials are exposed to high loading rates in applications such as blast and impact on protective structures, or meteorite impact on geological materials. A short review on experimental methods that are used for dynamic characterization of brittle materials will be given. A close interaction of experimental analysis and numerical simulation has turned out to be very helpful in analyzing experimental results. For this purpose, adequate numerical methods are required. Cohesive zone models are one possible method for the analysis of brittle failure as long as some degree of tension is present. Their recent successful application for meso-mechanical simulations of concrete in Hopkinson-type spallation tests provides new insight into the dynamic failure process. Failure under compressive loading is a particular challenge for numerical simulations as it involves crushing of material which in turn influences stress states in other parts of a structure. On a continuum scale, it can be modeled using more or less complex plasticity models combined with failure surfaces, as will be demonstrated for ceramics. Models which take microstructural cracking directly into account may provide a more physics-based approach for compressive failure in the future.

Time optimal control of a jet engine using a quasi-Hermite interpolation model. M.S. Thesis

NASA Technical Reports Server (NTRS)

Comiskey, J. G.

1979-01-01

This work made preliminary efforts to generate nonlinear numerical models of a two-spooled turbofan jet engine, and subject these models to a known method of generating global, nonlinear, time optimal control laws. The models were derived numerically, directly from empirical data, as a first step in developing an automatic modelling procedure.

Frequency-Response Identification of XV-15 Tilt-Rotor Aircraft Dynamics.

DTIC Science & Technology

1987-05-01

and the rotor interference with the other 2 aircraft elements are modeled in detail. Also modeled are numerous sub- system dynamics such as the engine ...scope and quality, as a dissertation for the degree of Doctor of Philosophy. (Electrical Engineering ) Approved for the University Com ittee on Graduate...Spectral Relationships .................................. 143 B.2 Numerical Study......................................... 149 B.3 Conclusions of

Comparison of free-piston Stirling engine model predictions with RE1000 engine test data

NASA Technical Reports Server (NTRS)

Tew, R. C., Jr.

1984-01-01

Predictions of a free-piston Stirling engine model are compared with RE1000 engine test data taken at NASA-Lewis Research Center. The model validation and the engine testing are being done under a joint interagency agreement between the Department of Energy's Oak Ridge National Laboratory and NASA-Lewis. A kinematic code developed at Lewis was upgraded to permit simulation of free-piston engine performance; it was further upgraded and modified at Lewis and is currently being validated. The model predicts engine performance by numerical integration of equations for each control volume in the working space. Piston motions are determined by numerical integration of the force balance on each piston or can be specified as Fourier series. In addition, the model Fourier analyzes the various piston forces to permit the construction of phasor force diagrams. The paper compares predicted and experimental values of power and efficiency and shows phasor force diagrams for the RE1000 engine displacer and piston. Further development plans for the model are also discussed.

Numerical Prediction of CCV in a PFI Engine using a Parallel LES Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ameen, Muhsin M; Mirzaeian, Mohsen; Millo, Federico

Cycle-to-cycle variability (CCV) is detrimental to IC engine operation and can lead to partial burn, misfire, and knock. Predicting CCV numerically is extremely challenging due to two key reasons. Firstly, high-fidelity methods such as large eddy simulation (LES) are required to accurately resolve the incylinder turbulent flowfield both spatially and temporally. Secondly, CCV is experienced over long timescales and hence the simulations need to be performed for hundreds of consecutive cycles. Ameen et al. (Int. J. Eng. Res., 2017) developed a parallel perturbation model (PPM) approach to dissociate this long time-scale problem into several shorter timescale problems. The strategy ismore » to perform multiple single-cycle simulations in parallel by effectively perturbing the initial velocity field based on the intensity of the in-cylinder turbulence. This strategy was demonstrated for motored engine and it was shown that the mean and variance of the in-cylinder flowfield was captured reasonably well by this approach. In the present study, this PPM approach is extended to simulate the CCV in a fired port-fuel injected (PFI) SI engine. Two operating conditions are considered – a medium CCV operating case corresponding to 2500 rpm and 16 bar BMEP and a low CCV case corresponding to 4000 rpm and 12 bar BMEP. The predictions from this approach are also shown to be similar to the consecutive LES cycles. Both the consecutive and PPM LES cycles are observed to under-predict the variability in the early stage of combustion. The parallel approach slightly underpredicts the cyclic variability at all stages of combustion as compared to the consecutive LES cycles. However, it is shown that the parallel approach is able to predict the coefficient of variation (COV) of the in-cylinder pressure and burn rate related parameters with sufficient accuracy, and is also able to predict the qualitative trends in CCV with changing operating conditions. The convergence of the statistics predicted by the PPM approach with respect to the number of consecutive cycles required for each parallel simulation is also investigated. It is shown that this new approach is able to give accurate predictions of the CCV in fired engines in less than one-tenth of the time required for the conventional approach of simulating consecutive engine cycles.« less

High-End Computing Challenges in Aerospace Design and Engineering

NASA Technical Reports Server (NTRS)

Bailey, F. Ronald

2004-01-01

High-End Computing (HEC) has had significant impact on aerospace design and engineering and is poised to make even more in the future. In this paper we describe four aerospace design and engineering challenges: Digital Flight, Launch Simulation, Rocket Fuel System and Digital Astronaut. The paper discusses modeling capabilities needed for each challenge and presents projections of future near and far-term HEC computing requirements. NASA's HEC Project Columbia is described and programming strategies presented that are necessary to achieve high real performance.

Formal Abstraction in Engineering Education--Challenges and Technology Support

ERIC Educational Resources Information Center

Neuper, Walther A.

2017-01-01

This is a position paper in the field of Engineering Education, which is at the very beginning in Europe. It relates challenges in the new field to the emerging technology of (Computer) Theorem Proving (TP). Experience shows, that "teaching" abstract models, for instance the wave equation in mechanical engineering and in electrical…

Embedding Enterprise in Science and Engineering Departments

ERIC Educational Resources Information Center

Handscombe, Robert D.; Rodriguez-Falcon, Elena; Patterson, Eann A.

2008-01-01

Purpose: This paper aims to focus on the attempts to implement the challenges of teaching enterprise to science and engineering students by the embedding approach chosen by the White Rose Centre for Enterprise (WRCE), one of the centres formed under the Science Engineering Challenge in the UK. Design/methodology/approach: WRCE's objective was to…

Piezoelectric Vibration Damping Study for Rotating Composite Fan Blades

NASA Technical Reports Server (NTRS)

Min, James B.; Duffy, Kirsten P.; Choi, Benjamin B.; Provenza, Andrew J.; Kray, Nicholas

2012-01-01

Resonant vibrations of aircraft engine blades cause blade fatigue problems in engines, which can lead to thicker and aerodynamically lower performing blade designs, increasing engine weight, fuel burn, and maintenance costs. In order to mitigate undesirable blade vibration levels, active piezoelectric vibration control has been investigated, potentially enabling thinner blade designs for higher performing blades and minimizing blade fatigue problems. While the piezoelectric damping idea has been investigated by other researchers over the years, very little study has been done including rotational effects. The present study attempts to fill this void. The particular objectives of this study were: (a) to develop and analyze a multiphysics piezoelectric finite element composite blade model for harmonic forced vibration response analysis coupled with a tuned RLC circuit for rotating engine blade conditions, (b) to validate a numerical model with experimental test data, and (c) to achieve a cost-effective numerical modeling capability which enables simulation of rotating blades within the NASA Glenn Research Center (GRC) Dynamic Spin Rig Facility. A numerical and experimental study for rotating piezoelectric composite subscale fan blades was performed. It was also proved that the proposed numerical method is feasible and effective when applied to the rotating blade base excitation model. The experimental test and multiphysics finite element modeling technique described in this paper show that piezoelectric vibration damping can significantly reduce vibrations of aircraft engine composite fan blades.

Defining Exercise Performance Metrics for Flight Hardware Development

NASA Technical Reports Server (NTRS)

Beyene, Nahon M.

2004-01-01

The space industry has prevailed over numerous design challenges in the spirit of exploration. Manned space flight entails creating products for use by humans and the Johnson Space Center has pioneered this effort as NASA's center for manned space flight. NASA Astronauts use a suite of flight exercise hardware to maintain strength for extravehicular activities and to minimize losses in muscle mass and bone mineral density. With a cycle ergometer, treadmill, and the Resistive Exercise Device available on the International Space Station (ISS), the Space Medicine community aspires to reproduce physical loading schemes that match exercise performance in Earth s gravity. The resistive exercise device presents the greatest challenge with the duty of accommodating 20 different exercises and many variations on the core set of exercises. This paper presents a methodology for capturing engineering parameters that can quantify proper resistive exercise performance techniques. For each specified exercise, the method provides engineering parameters on hand spacing, foot spacing, and positions of the point of load application at the starting point, midpoint, and end point of the exercise. As humans vary in height and fitness levels, the methodology presents values as ranges. In addition, this method shows engineers the proper load application regions on the human body. The methodology applies to resistive exercise in general and is in use for the current development of a Resistive Exercise Device. Exercise hardware systems must remain available for use and conducive to proper exercise performance as a contributor to mission success. The astronauts depend on exercise hardware to support extended stays aboard the ISS. Future plans towards exploration of Mars and beyond acknowledge the necessity of exercise. Continuous improvement in technology and our understanding of human health maintenance in space will allow us to support the exploration of Mars and the future of space exploration.

Biomimetic spiroid winglets for lift and drag control

NASA Astrophysics Data System (ADS)

Guerrero, Joel E.; Maestro, Dario; Bottaro, Alessandro

2012-01-01

In aeronautical engineering, drag reduction constitutes a challenge and there is room for improvement and innovative developments. The drag breakdown of a typical transport aircraft shows that the lift-induced drag can amount to as much as 40% of the total drag at cruise conditions and 80-90% of the total drag in take-off configuration. One way of reducing lift-induced drag is by using wingtip devices. By applying biomimetic abstraction of the principle behind a bird's wingtip feathers, we study spiroid wingtips, which look like an extended blended wingtip that bends upward by 360 degrees to form a large rigid ribbon. The numerical investigation of such a wingtip device is described and preliminary indications of its aerodynamic performance are provided.

The Emerging Field of RNA Nanotechnology

PubMed Central

Guo, Peixuan

2011-01-01

RNA can be designed and manipulated just like DNA while having different rules for base-pairing and displaying functions similar to proteins. The large variety of loops and motifs in RNA allow them to fold into numerous complicated structures. This diversity provides a platform for identifying viable building blocks for particle assemblies, substrate binding and manufacture engineering. RNA thermal stability allows production of multivalent nanostructures with defined stoichiometry. Here we review the unique qualities of RNA nanotechnology and their distinct properties inside the body. We describe techniques for constructing RNA nanoparticles from different building blocks and their applications in nanomedicine. Finally, we discuss challenges in predicting and synthesizing RNA and offer some perspectives on the yield and cost of RNA production. PMID:21102465

Geometrical frustration yields fibre formation in self-assembly

NASA Astrophysics Data System (ADS)

Lenz, Martin; Witten, Thomas A.

2017-11-01

Controlling the self-assembly of supramolecular structures is vital for living cells, and a central challenge for engineering at the nano- and microscales. Nevertheless, even particles without optimized shapes can robustly form well-defined morphologies. This is the case in numerous medical conditions where normally soluble proteins aggregate into fibres. Beyond the diversity of molecular mechanisms involved, we propose that fibres generically arise from the aggregation of irregular particles with short-range interactions. Using a minimal model of ill-fitting, sticky particles, we demonstrate robust fibre formation for a variety of particle shapes and aggregation conditions. Geometrical frustration plays a crucial role in this process, and accounts for the range of parameters in which fibres form as well as for their metastable character.

Exploring the Concept of HIV-Related Stigma

PubMed Central

Florom-Smith, Aubrey L.; De Santis, Joseph P.

2013-01-01

BACKGROUND HIV infection is a chronic, manageable illness. Despite advances in the care and treatment of people living with HIV infection, HIV-related stigma remains a challenge to HIV testing, care, and prevention. Numerous studies have documented the impact of HIV-related stigma among various groups of people living with HIV infection, but the concept of HIV-related stigma remains unclear. PURPOSE Concept exploration of HIV-related stigma via an integrative literature review was conducted in order to examine the existing knowledge base of this concept. METHODS Search engines were employed to review the existing knowledge base of this concept. CONCLUSION After the integrative literature review, an analysis of HIV-related stigma emerged. Implications for future concept analysis, research, and practice are included. PMID:22861652

BeamDyn: A High-Fidelity Wind Turbine Blade Solver in the FAST Modular Framework: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Q.; Sprague, M.; Jonkman, J.

2015-01-01

BeamDyn, a Legendre-spectral-finite-element implementation of geometrically exact beam theory (GEBT), was developed to meet the design challenges associated with highly flexible composite wind turbine blades. In this paper, the governing equations of GEBT are reformulated into a nonlinear state-space form to support its coupling within the modular framework of the FAST wind turbine computer-aided engineering (CAE) tool. Different time integration schemes (implicit and explicit) were implemented and examined for wind turbine analysis. Numerical examples are presented to demonstrate the capability of this new beam solver. An example analysis of a realistic wind turbine blade, the CX-100, is also presented asmore » validation.« less

Requirements for facilities and measurement techniques to support CFD development for hypersonic aircraft

NASA Technical Reports Server (NTRS)

Sellers, William L., III; Dwoyer, Douglas L.

1992-01-01

The design of a hypersonic aircraft poses unique challenges to the engineering community. Problems with duplicating flight conditions in ground based facilities have made performance predictions risky. Computational fluid dynamics (CFD) has been proposed as an additional means of providing design data. At the present time, CFD codes are being validated based on sparse experimental data and then used to predict performance at flight conditions with generally unknown levels of uncertainty. This paper will discuss the facility and measurement techniques that are required to support CFD development for the design of hypersonic aircraft. Illustrations are given of recent success in combining experimental and direct numerical simulation in CFD model development and validation for hypersonic perfect gas flows.

Carbon Nanotubes in Biomedical Applications: Factors, Mechanisms, and Remedies of Toxicity.

PubMed

Alshehri, Reem; Ilyas, Asad Muhammad; Hasan, Anwarul; Arnaout, Adnan; Ahmed, Farid; Memic, Adnan

2016-09-22

Carbon nanotubes (CNTs) represent one of the most studied allotropes of carbon. The unique physicochemical properties of CNTs make them among prime candidates for numerous applications in biomedical fields including drug delivery, gene therapy, biosensors, and tissue engineering applications. However, toxicity of CNTs has been a major concern for their use in biomedical applications. In this review, we present an overview of carbon nanotubes in biomedical applications; we particularly focus on various factors and mechanisms affecting their toxicity. We have discussed various parameters including the size, length, agglomeration, and impurities of CNTs that may cause oxidative stress, which is often the main mechanism of CNTs' toxicity. Other toxic pathways are also examined, and possible ways to overcome these challenges have been discussed.

Numerical Simulation of Creep Characteristic for Composite Rock Mass with Weak Interlayer

NASA Astrophysics Data System (ADS)

Li, Jian-guang; Zhang, Zuo-liang; Zhang, Yu-biao; Shi, Xiu-wen; Wei, Jian

2017-06-01

The composite rock mass with weak interlayer is widely exist in engineering, and it’s essential to research the creep behavior which could cause stability problems of rock engineering and production accidents. However, due to it is difficult to take samples, the losses and damages in delivery and machining process, we always cannot get enough natural layered composite rock mass samples, so the indirect test method has been widely used. In this paper, we used ANSYS software (a General Finite Element software produced by American ANSYS, Inc) to carry out the numerical simulation based on the uniaxial compression creep experiments of artificial composite rock mass with weak interlayer, after experimental data fitted. The results show that the laws obtained by numerical simulations and experiments are consistent. Thus confirmed that carry out numerical simulation for the creep characteristics of rock mass with ANSYS software is feasible, and this method can also be extended to other underground engineering of simulate the weak intercalations.

Fusing Symbolic and Numerical Diagnostic Computations

NASA Technical Reports Server (NTRS)

James, Mark

2007-01-01

X-2000 Anomaly Detection Language denotes a developmental computing language, and the software that establishes and utilizes the language, for fusing two diagnostic computer programs, one implementing a numerical analysis method, the other implementing a symbolic analysis method into a unified event-based decision analysis software system for realtime detection of events (e.g., failures) in a spacecraft, aircraft, or other complex engineering system. The numerical analysis method is performed by beacon-based exception analysis for multi-missions (BEAMs), which has been discussed in several previous NASA Tech Briefs articles. The symbolic analysis method is, more specifically, an artificial-intelligence method of the knowledge-based, inference engine type, and its implementation is exemplified by the Spacecraft Health Inference Engine (SHINE) software. The goal in developing the capability to fuse numerical and symbolic diagnostic components is to increase the depth of analysis beyond that previously attainable, thereby increasing the degree of confidence in the computed results. In practical terms, the sought improvement is to enable detection of all or most events, with no or few false alarms.

Excel spreadsheet in teaching numerical methods

NASA Astrophysics Data System (ADS)

Djamila, Harimi

2017-09-01

One of the important objectives in teaching numerical methods for undergraduates’ students is to bring into the comprehension of numerical methods algorithms. Although, manual calculation is important in understanding the procedure, it is time consuming and prone to error. This is specifically the case when considering the iteration procedure used in many numerical methods. Currently, many commercial programs are useful in teaching numerical methods such as Matlab, Maple, and Mathematica. These are usually not user-friendly by the uninitiated. Excel spreadsheet offers an initial level of programming, which it can be used either in or off campus. The students will not be distracted with writing codes. It must be emphasized that general commercial software is required to be introduced later to more elaborated questions. This article aims to report on a teaching numerical methods strategy for undergraduates engineering programs. It is directed to students, lecturers and researchers in engineering field.

Recent Advances in Application of Biosensors in Tissue Engineering

PubMed Central

Paul, Arghya; Lee, Yong-kyu; Jaffa, Ayad A.

2014-01-01

Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications in numerous industries including food and beverages, agricultural, environmental, medical diagnostics, and pharmaceutical industries and many more. Even though numerous biosensors have been developed for detection of proteins, peptides, enzymes, and numerous other biomolecules for diverse applications, their applications in tissue engineering have remained limited. In recent years, there has been a growing interest in application of novel biosensors in cell culture and tissue engineering, for example, real-time detection of small molecules such as glucose, lactose, and H2O2 as well as serum proteins of large molecular size, such as albumin and alpha-fetoprotein, and inflammatory cytokines, such as IFN-g and TNF-α. In this review, we provide an overview of the recent advancements in biosensors for tissue engineering applications. PMID:25165697

Recent advances in application of biosensors in tissue engineering.

PubMed

Hasan, Anwarul; Nurunnabi, Md; Morshed, Mahboob; Paul, Arghya; Polini, Alessandro; Kuila, Tapas; Al Hariri, Moustafa; Lee, Yong-kyu; Jaffa, Ayad A

2014-01-01

Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications in numerous industries including food and beverages, agricultural, environmental, medical diagnostics, and pharmaceutical industries and many more. Even though numerous biosensors have been developed for detection of proteins, peptides, enzymes, and numerous other biomolecules for diverse applications, their applications in tissue engineering have remained limited. In recent years, there has been a growing interest in application of novel biosensors in cell culture and tissue engineering, for example, real-time detection of small molecules such as glucose, lactose, and H2O2 as well as serum proteins of large molecular size, such as albumin and alpha-fetoprotein, and inflammatory cytokines, such as IFN-g and TNF-α. In this review, we provide an overview of the recent advancements in biosensors for tissue engineering applications.

Technology Challenges for Deep-Throttle Cryogenic Engines for Space Exploration

NASA Technical Reports Server (NTRS)

Brown, Kendall K.; Nelson, Karl W.

2005-01-01

Historically, cryogenic rocket engines have not been used for in-space applications due to their additional complexity, the mission need for high reliability, and the challenges of propellant boil-off. While the mission and vehicle architectures are not yet defined for the lunar and Martian robotic and human exploration objectives, cryogenic rocket engines offer the potential for higher performance and greater architecture/mission flexibility. In-situ cryogenic propellant production could enable a more robust exploration program by significantly reducing the propellant mass delivered to low earth orbit, thus warranting the evaluation of cryogenic rocket engines versus the hypergolic bi-propellant engines used in the Apollo program. A multi-use engine. one which can provide the functionality that separate engines provided in the Apollo mission architecture, is desirable for lunar and Mars exploration missions because it increases overall architecture effectiveness through commonality and modularity. The engine requirement derivation process must address each unique mission application and each unique phase within each mission. The resulting requirements, such as thrust level, performance, packaging, bum duration, number of operations; required impulses for each trajectory phase; operation after extended space or surface exposure; availability for inspection and maintenance; throttle range for planetary descent, ascent, acceleration limits and many more must be addressed. Within engine system studies, the system and component technology, capability, and risks must be evaluated and a balance between the appropriate amount of technology-push and technology-pull must be addressed. This paper will summarize many of the key technology challenges associated with using high-performance cryogenic liquid propellant rocket engine systems and components in the exploration program architectures. The paper is divided into two areas. The first area describes how the mission requirements affect the engine system requirements and create system level technology challenges. An engine system architecture for multiple applications or a family of engines based upon a set of core technologies, design, and fabrication approaches may reduce overall programmatic cost and risk. The engine system discussion will also address the characterization of engine cycle figures of merit, configurations, and design approaches for some in-space vehicle alternatives under consideration. The second area evaluates the component-level technology challenges induced from the system requirements. Component technology issues are discussed addressing injector, thrust chamber, ignition system, turbopump assembly, and valve design for the challenging requirements of high reliability, robustness, fault tolerance, deep throttling, reasonable performance (with respect to weight and specific impulse).

Technology Challenges for Deep-Throttle Cryogenic Engines for Space Exploration

NASA Astrophysics Data System (ADS)

Brown, Kendall K.; Nelson, Karl W.

2005-02-01

Historically, cryogenic rocket engines have not been used for in-space applications due to their additional complexity, the mission need for high reliability, and the challenges of propellant boil-off. While the mission and vehicle architectures are not yet defined for the lunar and Martian robotic and human exploration objectives, cryogenic rocket engines offer the potential for higher performance and greater architecture/mission flexibility. In-situ cryogenic propellant production could enable a more robust exploration program by significantly reducing the propellant mass delivered to low earth orbit, thus warranting the evaluation of cryogenic rocket engines versus the hypergolic bipropellant engines used in the Apollo program. A multi-use engine, one which can provide the functionality that separate engines provided in the Apollo mission architecture, is desirable for lunar and Mars exploration missions because it increases overall architecture effectiveness through commonality and modularity. The engine requirement derivation process must address each unique mission application and each unique phase within each mission. The resulting requirements, such as thrust level, performance, packaging, burn duration, number of operations; required impulses for each trajectory phase; operation after extended space or surface exposure; availability for inspection and maintenance; throttle range for planetary descent, ascent, acceleration limits and many more must be addressed. Within engine system studies, the system and component technology, capability, and risks must be evaluated and a balance between the appropriate amount of technology-push and technology-pull must be addressed. This paper will summarize many of the key technology challenges associated with using high-performance cryogenic liquid propellant rocket engine systems and components in the exploration program architectures. The paper is divided into two areas. The first area describes how the mission requirements affect the engine system requirements and create system level technology challenges. An engine system architecture for multiple applications or a family of engines based upon a set of core technologies, design, and fabrication approaches may reduce overall programmatic cost and risk. The engine system discussion will also address the characterization of engine cycle figures of merit, configurations, and design approaches for some in-space vehicle alternatives under consideration. The second area evaluates the component-level technology challenges induced from the system requirements. Component technology issues are discussed addressing injector, thrust chamber, ignition system, turbopump assembly, and valve design for the challenging requirements of high reliability, robustness, fault tolerance, deep throttling, reasonable performance (with respect to weight and specific impulse).

Hydrogel scaffolds for tissue engineering: Progress and challenges

PubMed Central

El-Sherbiny, Ibrahim M.; Yacoub, Magdi H.

2013-01-01

Designing of biologically active scaffolds with optimal characteristics is one of the key factors for successful tissue engineering. Recently, hydrogels have received a considerable interest as leading candidates for engineered tissue scaffolds due to their unique compositional and structural similarities to the natural extracellular matrix, in addition to their desirable framework for cellular proliferation and survival. More recently, the ability to control the shape, porosity, surface morphology, and size of hydrogel scaffolds has created new opportunities to overcome various challenges in tissue engineering such as vascularization, tissue architecture and simultaneous seeding of multiple cells. This review provides an overview of the different types of hydrogels, the approaches that can be used to fabricate hydrogel matrices with specific features and the recent applications of hydrogels in tissue engineering. Special attention was given to the various design considerations for an efficient hydrogel scaffold in tissue engineering. Also, the challenges associated with the use of hydrogel scaffolds were described. PMID:24689032

Fluid dynamic modeling of junctions in internal combustion engine inlet and exhaust systems

NASA Astrophysics Data System (ADS)

Chalet, David; Chesse, Pascal

2010-10-01

The modeling of inlet and exhaust systems of internal combustion engine is very important in order to evaluate the engine performance. This paper presents new pressure losses models which can be included in a one dimensional engine simulation code. In a first part, a CFD analysis is made in order to show the importance of the density in the modeling approach. Then, the CFD code is used, as a numerical test bench, for the pressure losses models development. These coefficients depend on the geometrical characteristics of the junction and an experimental validation is made with the use of a shock tube test bench. All the models are then included in the engine simulation code of the laboratory. The numerical calculation of unsteady compressible flow, in each pipe of the inlet and exhaust systems, is made and the calculated engine torque is compared with experimental measurements.

Numerical method to determine mechanical parameters of engineering design in rock masses.

PubMed

Xue, Ting-He; Xiang, Yi-Qiang; Guo, Fa-Zhong

2004-07-01

This paper proposes a new continuity model for engineering in rock masses and a new schematic method for reporting the engineering of rock continuity. This method can be used to evaluate the mechanics of every kind of medium; and is a new way to determine the mechanical parameters used in engineering design in rock masses. In the numerical simulation, the experimental parameters of intact rock were combined with the structural properties of field rock. The experimental results for orthogonally-jointed rock are given. The results included the curves of the stress-strain relationship of some rock masses, the curve of the relationship between the dimension Delta and the uniaxial pressure-resistant strength sc of these rock masses, and pictures of the destructive procedure of some rock masses in uniaxial or triaxial tests, etc. Application of the method to engineering design in rock masses showed the potential of its application to engineering practice.

Challenges of the English Teacher in the Engineering Faculty

ERIC Educational Resources Information Center

Astrid, Ramirez Valencia; Isabel, Borja-Alarcón; Alfonso, López-Vega

2018-01-01

Changes experienced in recent times focus their attention on new and multiple challenges that must be assumed by the English teacher, in the engineering context, which becomes a challenge against the demands by the current world from the English teacher in Colombia. This situation needs to be analyzed and studied. This article addresses the…

Hard but Not Too Hard: Challenging Courses and Engineering Students

ERIC Educational Resources Information Center

Martin, Jason H.; Hands, Krista B.; Lancaster, Stephen M.; Trytten, Deborah A.; Murphy, Teri J.

2008-01-01

Some professors claim college students seek the easy way out and prefer classes that lack challenge. In a multidisciplinary and multi-institutional ethnographic research study of the attainment of gender parity in an engineering department, it emerged that student attitudes toward challenge did not support this perception. By far, the majority of…

Numerical Aerodynamic Simulation

NASA Technical Reports Server (NTRS)

1989-01-01

An overview of historical and current numerical aerodynamic simulation (NAS) is given. The capabilities and goals of the Numerical Aerodynamic Simulation Facility are outlined. Emphasis is given to numerical flow visualization and its applications to structural analysis of aircraft and spacecraft bodies. The uses of NAS in computational chemistry, engine design, and galactic evolution are mentioned.

Comparing the Effectiveness of Blended, Semi-Flipped, and Flipped Formats in an Engineering Numerical Methods Course

ERIC Educational Resources Information Center

Clark, Renee M.; Kaw, Autar; Besterfield-Sacre, Mary

2016-01-01

Blended, flipped, and semi-flipped instructional approaches were used in various sections of a numerical methods course for undergraduate mechanical engineers. During the spring of 2014, a blended approach was used; in the summer of 2014, a combination of blended and flipped instruction was used to deliver a semi-flipped course; and in the fall of…

Bioresorbable scaffolds for bone tissue engineering: optimal design, fabrication, mechanical testing and scale-size effects analysis.

PubMed

Coelho, Pedro G; Hollister, Scott J; Flanagan, Colleen L; Fernandes, Paulo R

2015-03-01

Bone scaffolds for tissue regeneration require an optimal trade-off between biological and mechanical criteria. Optimal designs may be obtained using topology optimization (homogenization approach) and prototypes produced using additive manufacturing techniques. However, the process from design to manufacture remains a research challenge and will be a requirement of FDA design controls to engineering scaffolds. This work investigates how the design to manufacture chain affects the reproducibility of complex optimized design characteristics in the manufactured product. The design and prototypes are analyzed taking into account the computational assumptions and the final mechanical properties determined through mechanical tests. The scaffold is an assembly of unit-cells, and thus scale size effects on the mechanical response considering finite periodicity are investigated and compared with the predictions from the homogenization method which assumes in the limit infinitely repeated unit cells. Results show that a limited number of unit-cells (3-5 repeated on a side) introduce some scale-effects but the discrepancies are below 10%. Higher discrepancies are found when comparing the experimental data to numerical simulations due to differences between the manufactured and designed scaffold feature shapes and sizes as well as micro-porosities introduced by the manufacturing process. However good regression correlations (R(2) > 0.85) were found between numerical and experimental values, with slopes close to 1 for 2 out of 3 designs. Copyright © 2015 IPEM. Published by Elsevier Ltd. All rights reserved.

Approaches to Integrating Engineering in STEM Units and Student Achievement Gains

ERIC Educational Resources Information Center

Crotty, Elizabeth A.; Guzey, Selcen S.; Roehrig, Gillian H.; Glancy, Aran W.; Ring-Whalen, Elizabeth A.

2017-01-01

This study examined different approaches to integrating engineering practices in science, technology, engineering, and mathematics (STEM) curriculum units. These various approaches were correlated with student outcomes on engineering assessment items. There are numerous reform documents in the USA and around the world that emphasize the need to…

Promoting Collaborative Problem-Solving Skills in a Course on Engineering Grand Challenges

ERIC Educational Resources Information Center

Zou, Tracy X. P.; Mickleborough, Neil C.

2015-01-01

The ability to solve problems with people of diverse backgrounds is essential for engineering graduates. A course on engineering grand challenges was designed to promote collaborative problem-solving (CPS) skills. One unique component is that students need to work both within their own team and collaborate with the other team to tackle engineering…

Tackling some of the most intricate geophysical challenges via high-performance computing

NASA Astrophysics Data System (ADS)

Khosronejad, A.

2016-12-01

Recently, world has been witnessing significant enhancements in computing power of supercomputers. Computer clusters in conjunction with the advanced mathematical algorithms has set the stage for developing and applying powerful numerical tools to tackle some of the most intricate geophysical challenges that today`s engineers face. One such challenge is to understand how turbulent flows, in real-world settings, interact with (a) rigid and/or mobile complex bed bathymetry of waterways and sea-beds in the coastal areas; (b) objects with complex geometry that are fully or partially immersed; and (c) free-surface of waterways and water surface waves in the coastal area. This understanding is especially important because the turbulent flows in real-world environments are often bounded by geometrically complex boundaries, which dynamically deform and give rise to multi-scale and multi-physics transport phenomena, and characterized by multi-lateral interactions among various phases (e.g. air/water/sediment phases). Herein, I present some of the multi-scale and multi-physics geophysical fluid mechanics processes that I have attempted to study using an in-house high-performance computational model, the so-called VFS-Geophysics. More specifically, I will present the simulation results of turbulence/sediment/solute/turbine interactions in real-world settings. Parts of the simulations I present are performed to gain scientific insights into the processes such as sand wave formation (A. Khosronejad, and F. Sotiropoulos, (2014), Numerical simulation of sand waves in a turbulent open channel flow, Journal of Fluid Mechanics, 753:150-216), while others are carried out to predict the effects of climate change and large flood events on societal infrastructures ( A. Khosronejad, et al., (2016), Large eddy simulation of turbulence and solute transport in a forested headwater stream, Journal of Geophysical Research:, doi: 10.1002/2014JF003423).

Cyber-Informed Engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, Robert S.; Benjamin, Jacob; Wright, Virginia L.

A continuing challenge for engineers who utilize digital systems is to understand the impact of cyber-attacks across the entire product and program lifecycle. This is a challenge due to the evolving nature of cyber threats that may impact the design, development, deployment, and operational phases of all systems. Cyber Informed Engineering is the process by which engineers are made aware of both how to use their engineering knowledge to positively impact the cyber security in the processes by which they architect and design components and the services and security of the components themselves.

The Radical Flank Effect and Cross-occupational Collaboration for Technology Development during a Power Shift

PubMed Central

Truelove, Emily; Kellogg, Katherine C.

2016-01-01

This 12-month ethnographic study of an early entrant into the U.S. car-sharing industry demonstrates that when an organization shifts its focus from developing radical new technology to incrementally improving this technology, the shift may spark an internal power struggle between the dominant engineering group and a challenger occupational group such as the marketing group. Analyzing 42 projects in two time periods that required collaboration between engineering and marketing during such a shift, we show how cross-occupational collaboration under these conditions can be facilitated by a radical flank threat, through which the bargaining power of moderates is strengthened by the presence of a more-radical group. In the face of a strong threat by radical members of a challenger occupational group, moderate members of the dominant engineering group may change their perceptions of their power to resist challengers’ demands and begin to distinguish between the goals of radical versus more-moderate challengers. To maintain as much power as possible and prevent the more-dramatic change in engineering occupational goals demanded by radical challengers, moderate engineers may build a coalition with moderate challengers and collaborate for incremental technology development. PMID:28424533

Optimization of automotive Rankine cycle waste heat recovery under various engine operating condition

NASA Astrophysics Data System (ADS)

Punov, Plamen; Milkov, Nikolay; Danel, Quentin; Perilhon, Christelle; Podevin, Pierre; Evtimov, Teodossi

2017-02-01

An optimization study of the Rankine cycle as a function of diesel engine operating mode is presented. The Rankine cycle here, is studied as a waste heat recovery system which uses the engine exhaust gases as heat source. The engine exhaust gases parameters (temperature, mass flow and composition) were defined by means of numerical simulation in advanced simulation software AVL Boost. Previously, the engine simulation model was validated and the Vibe function parameters were defined as a function of engine load. The Rankine cycle output power and efficiency was numerically estimated by means of a simulation code in Python(x,y). This code includes discretized heat exchanger model and simplified model of the pump and the expander based on their isentropic efficiency. The Rankine cycle simulation revealed the optimum value of working fluid mass flow and evaporation pressure according to the heat source. Thus, the optimal Rankine cycle performance was obtained over the engine operating map.

ADDRESSING ENVIRONMENTAL ENGINEERING CHALLENGES WITH COMPUTATIONAL FLUID DYNAMICS

EPA Science Inventory

This paper discusses the status and application of Computational Fluid Dynamics )CFD) models to address environmental engineering challenges for more detailed understanding of air pollutant source emissions, atmospheric dispersion and resulting human exposure. CFD simulations ...

Programmable probiotics for detection of cancer in urine

PubMed Central

Danino, Tal; Prindle, Arthur; Kwong, Gabriel A.; Skalak, Matthew; Li, Howard; Allen, Kaitlin; Hasty, Jeff; Bhatia, Sangeeta N.

2015-01-01

Rapid advances in the forward engineering of genetic circuitry in living cells has positioned synthetic biology as a potential means to solve numerous biomedical problems, including disease diagnosis and therapy. One challenge in exploiting synthetic biology for translational applications is to engineer microbes that are well tolerated by patients and seamlessly integrate with existing clinical methods. We use the safe and widely used probiotic Escherichia coli Nissle 1917 to develop an orally administered diagnostic that can noninvasively indicate the presence of liver metastasis by producing easily detectable signals in urine. Our microbial diagnostic generated a high-contrast urine signal through selective expansion in liver metastases (106-fold enrichment) and high expression of a lacZ reporter maintained by engineering a stable plasmid system. The lacZ reporter cleaves a substrate to produce a small molecule that can be detected in urine. E. coli Nissle 1917 robustly colonized tumor tissue in rodent models of liver metastasis after oral delivery but did not colonize healthy organs or fibrotic liver tissue. We saw no deleterious health effects on the mice for more than 12 months after oral delivery. Our results demonstrate that probiotics can be programmed to safely and selectively deliver synthetic gene circuits to diseased tissue microenvironments in vivo. PMID:26019220

Surrogate species selection for assessing potential adverse environmental impacts of genetically engineered insect-resistant plants on non-target organisms

PubMed Central

Carstens, Keri; Cayabyab, Bonifacio; De Schrijver, Adinda; Gadaleta, Patricia G; Hellmich, Richard L; Romeis, Jörg; Storer, Nicholas; Valicente, Fernando H; Wach, Michael

2014-01-01

Most regulatory authorities require that developers of genetically engineered insect-resistant (GEIR) crops evaluate the potential for these crops to have adverse impacts on valued non-target organisms (NTOs), i.e., organisms not intended to be controlled by the trait. In many cases, impacts to NTOs are assessed using surrogate species, and it is critical that the data derived from surrogates accurately predict any adverse impacts likely to be observed from the use of the crop in the agricultural context. The key is to select surrogate species that best represent the valued NTOs in the location where the crop is going to be introduced, but this selection process poses numerous challenges for the developers of GE crops who will perform the tests, as well as for the ecologists and regulators who will interpret the test results. These issues were the subject of a conference “Surrogate Species Selection for Assessing Potential Adverse Environmental Impacts of Genetically Engineered Plants on Non-Target Organisms” convened by the Center for Environmental Risk Assessment, ILSI Research Foundation. This report summarizes the proceedings of the conference, including the presentations, discussions and the points of consensus agreed to by the participants. PMID:24637519

Two-phase unsaturated flow at Yucca Mountain, Nevada: A report on current understanding

NASA Astrophysics Data System (ADS)

Pruess, Karsten

Thick unsaturated zones in semi-arid regions have some unique attributes that are favorable for long-term isolation of hazardous wastes. The disposal concept at Yucca Mountain takes advantage of low ambient water fluxes. Evaluation of site suitability must be based on an understanding of two-phase (liquid-gas) fluid flow and heat transfer processes in a heterogeneous, fractured rock mass. A large body of relevant knowledge has been accumulated in various fields, including petroleum and geothermal reservoir engineering, chemical engineering, civil engineering, and soil science. Complications at Yucca Mountain arise from the partly episodic and localized nature of water seepage in fracture networks. This limits the applicability of spatial and temporal averaging, and poses great challenges for numerical modeling. Significant flow and heat transfer effects may occur in the gas phase. Observations of natural and man-made chemical tracers as well as controlled field experiments have provided much useful information on mass transport at Yucca Mountain, including the occurrence of fast preferential flow. It is now clear that fracture-matrix interactions are considerably weaker than would be expected from a concept of water flowing in fractures as areally extensive sheets. The Yucca Mountain system is expected to be quite robust in coping with larger seepage rates, as may occur under future more pluvial climatic conditions.

Advanced Computational Methods in Bio-Mechanics.

PubMed

Al Qahtani, Waleed M S; El-Anwar, Mohamed I

2018-04-15

A novel partnership between surgeons and machines, made possible by advances in computing and engineering technology, could overcome many of the limitations of traditional surgery. By extending surgeons' ability to plan and carry out surgical interventions more accurately and with fewer traumas, computer-integrated surgery (CIS) systems could help to improve clinical outcomes and the efficiency of healthcare delivery. CIS systems could have a similar impact on surgery to that long since realised in computer-integrated manufacturing. Mathematical modelling and computer simulation have proved tremendously successful in engineering. Computational mechanics has enabled technological developments in virtually every area of our lives. One of the greatest challenges for mechanists is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences, and medicine. Biomechanics has significant potential for applications in orthopaedic industry, and the performance arts since skills needed for these activities are visibly related to the human musculoskeletal and nervous systems. Although biomechanics is widely used nowadays in the orthopaedic industry to design orthopaedic implants for human joints, dental parts, external fixations and other medical purposes, numerous researches funded by billions of dollars are still running to build a new future for sports and human healthcare in what is called biomechanics era.

Automated reverse engineering of nonlinear dynamical systems.

PubMed

Bongard, Josh; Lipson, Hod

2007-06-12

Complex nonlinear dynamics arise in many fields of science and engineering, but uncovering the underlying differential equations directly from observations poses a challenging task. The ability to symbolically model complex networked systems is key to understanding them, an open problem in many disciplines. Here we introduce for the first time a method that can automatically generate symbolic equations for a nonlinear coupled dynamical system directly from time series data. This method is applicable to any system that can be described using sets of ordinary nonlinear differential equations, and assumes that the (possibly noisy) time series of all variables are observable. Previous automated symbolic modeling approaches of coupled physical systems produced linear models or required a nonlinear model to be provided manually. The advance presented here is made possible by allowing the method to model each (possibly coupled) variable separately, intelligently perturbing and destabilizing the system to extract its less observable characteristics, and automatically simplifying the equations during modeling. We demonstrate this method on four simulated and two real systems spanning mechanics, ecology, and systems biology. Unlike numerical models, symbolic models have explanatory value, suggesting that automated "reverse engineering" approaches for model-free symbolic nonlinear system identification may play an increasing role in our ability to understand progressively more complex systems in the future.

The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications

PubMed Central

Ayerst, Bethanie I.; Merry, Catherine L.R.; Day, Anthony J.

2017-01-01

High sulfation, low cost, and the status of heparin as an already FDA- and EMA- approved product, mean that its inclusion in tissue engineering (TE) strategies is becoming increasingly popular. However, the use of heparin may represent a naïve approach. This is because tissue formation is a highly orchestrated process, involving the temporal expression of numerous growth factors and complex signaling networks. While heparin may enhance the retention and activity of certain growth factors under particular conditions, its binding ‘promiscuity’ means that it may also inhibit other factors that, for example, play an important role in tissue maintenance and repair. Within this review we focus on articular cartilage, highlighting the complexities and highly regulated processes that are involved in its formation, and the challenges that exist in trying to effectively engineer this tissue. Here we discuss the opportunities that glycosaminoglycans (GAGs) may provide in advancing this important area of regenerative medicine, placing emphasis on the need to move away from the common use of heparin, and instead focus research towards the utility of specific GAG preparations that are able to modulate the activity of growth factors in a more controlled and defined manner, with less off-target effects. PMID:28608822

Numerical discretization-based estimation methods for ordinary differential equation models via penalized spline smoothing with applications in biomedical research.

PubMed

Wu, Hulin; Xue, Hongqi; Kumar, Arun

2012-06-01

Differential equations are extensively used for modeling dynamics of physical processes in many scientific fields such as engineering, physics, and biomedical sciences. Parameter estimation of differential equation models is a challenging problem because of high computational cost and high-dimensional parameter space. In this article, we propose a novel class of methods for estimating parameters in ordinary differential equation (ODE) models, which is motivated by HIV dynamics modeling. The new methods exploit the form of numerical discretization algorithms for an ODE solver to formulate estimating equations. First, a penalized-spline approach is employed to estimate the state variables and the estimated state variables are then plugged in a discretization formula of an ODE solver to obtain the ODE parameter estimates via a regression approach. We consider three different order of discretization methods, Euler's method, trapezoidal rule, and Runge-Kutta method. A higher-order numerical algorithm reduces numerical error in the approximation of the derivative, which produces a more accurate estimate, but its computational cost is higher. To balance the computational cost and estimation accuracy, we demonstrate, via simulation studies, that the trapezoidal discretization-based estimate is the best and is recommended for practical use. The asymptotic properties for the proposed numerical discretization-based estimators are established. Comparisons between the proposed methods and existing methods show a clear benefit of the proposed methods in regards to the trade-off between computational cost and estimation accuracy. We apply the proposed methods t an HIV study to further illustrate the usefulness of the proposed approaches. © 2012, The International Biometric Society.

OpenGeoSys: Performance-Oriented Computational Methods for Numerical Modeling of Flow in Large Hydrogeological Systems

NASA Astrophysics Data System (ADS)

Naumov, D.; Fischer, T.; Böttcher, N.; Watanabe, N.; Walther, M.; Rink, K.; Bilke, L.; Shao, H.; Kolditz, O.

2014-12-01

OpenGeoSys (OGS) is a scientific open source code for numerical simulation of thermo-hydro-mechanical-chemical processes in porous and fractured media. Its basic concept is to provide a flexible numerical framework for solving multi-field problems for applications in geoscience and hydrology as e.g. for CO2 storage applications, geothermal power plant forecast simulation, salt water intrusion, water resources management, etc. Advances in computational mathematics have revolutionized the variety and nature of the problems that can be addressed by environmental scientists and engineers nowadays and an intensive code development in the last years enables in the meantime the solutions of much larger numerical problems and applications. However, solving environmental processes along the water cycle at large scales, like for complete catchment or reservoirs, stays computationally still a challenging task. Therefore, we started a new OGS code development with focus on execution speed and parallelization. In the new version, a local data structure concept improves the instruction and data cache performance by a tight bundling of data with an element-wise numerical integration loop. Dedicated analysis methods enable the investigation of memory-access patterns in the local and global assembler routines, which leads to further data structure optimization for an additional performance gain. The concept is presented together with a technical code analysis of the recent development and a large case study including transient flow simulation in the unsaturated / saturated zone of the Thuringian Syncline, Germany. The analysis is performed on a high-resolution mesh (up to 50M elements) with embedded fault structures.

A critical evaluation of various methods for the analysis of flow-solid interaction in a nest of thin cylinders subjected to cross flows

NASA Technical Reports Server (NTRS)

Kim, Sang-Wook

1987-01-01

Various experimental, analytical, and numerical analysis methods for flow-solid interaction of a nest of cylinders subjected to cross flows are reviewed. A nest of cylinders subjected to cross flows can be found in numerous engineering applications including the Space Shuttle Maine Engine-Main Injector Assembly (SSME-MIA) and nuclear reactor heat exchangers. Despite its extreme importance in engineering applications, understanding of the flow-solid interaction process is quite limited and design of the tube banks are mostly dependent on experiments and/or experimental correlation equations. For future development of major numerical analysis methods for the flow-solid interaction of a nest of cylinders subjected to cross flow, various turbulence models, nonlinear structural dynamics, and existing laminar flow-solid interaction analysis methods are included.

Automation based on knowledge modeling theory and its applications in engine diagnostic systems using Space Shuttle Main Engine vibrational data. M.S. Thesis

NASA Technical Reports Server (NTRS)

Kim, Jonnathan H.

1995-01-01

Humans can perform many complicated tasks without explicit rules. This inherent and advantageous capability becomes a hurdle when a task is to be automated. Modern computers and numerical calculations require explicit rules and discrete numerical values. In order to bridge the gap between human knowledge and automating tools, a knowledge model is proposed. Knowledge modeling techniques are discussed and utilized to automate a labor and time intensive task of detecting anomalous bearing wear patterns in the Space Shuttle Main Engine (SSME) High Pressure Oxygen Turbopump (HPOTP).

Numerical modeling of interaction of the aircraft engine with concrete protective structures

NASA Astrophysics Data System (ADS)

Radchenko, P. A.; Batuev, S. P.; Radchenko, A. V.; Plevkov, V. S.

2018-01-01

The paper presents numerical modeling results considering interaction of Boeing 747 aircraft engine with nuclear power station protective shell. Protective shell has been given as a reinforced concrete structure with complex scheme of reinforcement. The engine has been simulated by cylinder projectile made from titanium alloy. The interaction velocity has comprised 180 m/s. The simulation is three-dimensional solved by finite element method using the author’s own software package EFES. Fracture and fragmentation of materials have been considered in calculations. Program software has been assessed to be used in calculation of multiple-contact objectives.

The Transformative Potential of Engaging in Science Inquiry-Based Challenges: The ATSE Wonder of Science Challenge

ERIC Educational Resources Information Center

Tomas, Louisa; Jackson, Cliff; Carlisle, Karen

2014-01-01

In 2012, the Australian Academy of Technological Sciences and Engineering (ATSE) piloted the "Wonder of Science Challenge" with a view to enhance school students' interest in Science, Technology, Engineering and Mathematics (STEM). Students in 15 schools across northern Queensland were provided with an inquiry-based research problem and…

Institutional Memory Preservation at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Coffey, J.; Moreman, Douglas; Dyer, J.; Hemminger, J. A.

1999-01-01

In this era of downsizing and deficit reduction, the preservation of institutional memory is a widespread concern for U.S. companies and governmental agencies. The National Aeronautical and Space Administration faces the pending retirement of many of the agency's long-term, senior engineers. NASA has a marvelous long-term history of success, but the agency faces a recurring problem caused by the loss of these engineers' unique knowledge and perspectives on NASA's role in aeronautics and space exploration. The current work describes a knowledge elicitation effort aimed at demonstrating the feasibility of preserving the more personal, heuristic knowledge accumulated over the years by NASA engineers, as contrasted with the "textbook" knowledge of launch vehicles. Work on this project was performed at NASA Glenn Research Center and elsewhere, and focused on launch vehicle systems integration. The initial effort was directed toward an historic view of the Centaur upper stage which is powered by two RL-10 engines. Various experts were consulted, employing a variety of knowledge elicitation techniques, regarding the Centaur and RL-10. Their knowledge is represented in searchable Web-based multimedia presentations. This paper discusses the various approaches to knowledge elicitation and knowledge representation employed, and assesses successes and challenges in trying to perform large-scale knowledge preservation of institutional memory. It is anticipated that strategies for knowledge elicitation and representation that have been developed in this grant will be utilized to elicit knowledge in a variety of domains including the complex heuristics that underly use of simulation software packages such as that being explored in the Expert System Architecture for Rocket Engine Numerical Simulators.

Technology Transfer Challenges for High-Assurance Software Engineering Tools

NASA Technical Reports Server (NTRS)

Koga, Dennis (Technical Monitor); Penix, John; Markosian, Lawrence Z.

2003-01-01

In this paper, we describe our experience with the challenges thar we are currently facing in our effort to develop advanced software verification and validation tools. We categorize these challenges into several areas: cost benefits modeling, tool usability, customer application domain, and organizational issues. We provide examples of challenges in each area and identrfj, open research issues in areas which limit our ability to transfer high-assurance software engineering tools into practice.

Integrating International Engineering Organizations For Successful ISS Operations

NASA Technical Reports Server (NTRS)

Blome, Elizabeth; Duggan, Matt; Patten, L.; Pieterek, Hhtrud

2006-01-01

The International Space Station (ISS) is a multinational orbiting space laboratory that is built in cooperation with 16 nations. The design and sustaining engineering expertise is spread worldwide. As the number of Partners with orbiting elements on the ISS grows, the challenge NASA is facing as the ISS integrator is to ensure that engineering expertise and data are accessible in a timely fashion to ensure ongoing operations and mission success. Integrating international engineering teams requires definition and agreement on common processes and responsibilities, joint training and the emergence of a unique engineering team culture. ISS engineers face daunting logistical and political challenges regarding data sharing requirements. To assure systematic information sharing and anomaly resolution of integrated anomalies, the ISS Partners are developing multi-lateral engineering interface procedures. Data sharing and individual responsibility are key aspects of this plan. This paper describes several examples of successful multilateral anomaly resolution. These successes were used to form the framework of the Partner to Partner engineering interface procedures, and this paper describes those currently documented multilateral engineering processes. Furthermore, it addresses the challenges experienced to date, and the forward work expected in establishing a successful working relationship with Partners as their hardware is launched.

Challenges and Promises of Overcoming Epistemological and Methodological Partiality: Advancing Engineering Education through Acceptance of Diverse Ways of Knowing

ERIC Educational Resources Information Center

Douglas, Elliot P.; Koro-Ljungberg, Mirka; Borrego, Maura

2010-01-01

The purpose of this paper is to explore some challenges and promises when the epistemological diversity embedded in qualitative research traditions is introduced to research communities with one dominant research paradigm, such as engineering education. Literature is used from other fields and empirical data are used from engineering education,…

Nanoshells for photothermal therapy: a Monte-Carlo based numerical study of their design tolerance

PubMed Central

Grosges, Thomas; Barchiesi, Dominique; Kessentini, Sameh; Gréhan, Gérard; de la Chapelle, Marc Lamy

2011-01-01

The optimization of the coated metallic nanoparticles and nanoshells is a current challenge for biological applications, especially for cancer photothermal therapy, considering both the continuous improvement of their fabrication and the increasing requirement of efficiency. The efficiency of the coupling between illumination with such nanostructures for burning purposes depends unevenly on their geometrical parameters (radius, thickness of the shell) and material parameters (permittivities which depend on the illumination wavelength). Through a Monte-Carlo method, we propose a numerical study of such nanodevice, to evaluate tolerances (or uncertainty) on these parameters, given a threshold of efficiency, to facilitate the design of nanoparticles. The results could help to focus on the relevant parameters of the engineering process for which the absorbed energy is the most dependant. The Monte-Carlo method confirms that the best burning efficiency are obtained for hollow nanospheres and exhibit the sensitivity of the absorbed electromagnetic energy as a function of each parameter. The proposed method is general and could be applied in design and development of new embedded coated nanomaterials used in biomedicine applications. PMID:21698021

Comparison of Quasi-Conservative Pressure-Based and Fully-Conservative Formulations for the Simulation of Transcritical Flows

NASA Astrophysics Data System (ADS)

Lacaze, Guilhem; Oefelein, Joseph

2016-11-01

High-pressure flows are known to be challenging to simulate due to thermodynamic non-linearities occurring in the vicinity of the pseudo-boiling line. This study investigates the origin of this issue by analyzing the behavior of thermodynamic processes at elevated pressure and low temperature. We show that under transcritical conditions, non-linearities significantly amplify numerical errors associated with construction of fluxes. These errors affect the local density and energy balances, which in turn creates pressure oscillations. For that reason, solvers based on a conservative system of equations that transport density and total energy are subject to unphysical pressure variations in gradient regions. These perturbations hinder numerical stability and degrade the accuracy of predictions. To circumvent this problem, the governing system can be reformulated to a pressure-based treatment of energy. We present comparisons between the pressure-based and fully conservative formulations using a progressive set of canonical cases, including a cryogenic turbulent mixing layer at rocket engine conditions. Department of Energy, Office of Science, Basic Energy Sciences Program.

Numerical simulation of turbulent stratified flame propagation in a closed vessel

NASA Astrophysics Data System (ADS)

Gruselle, Catherine; Lartigue, Ghislain; Pepiot, Perrine; Moureau, Vincent; D'Angelo, Yves

2012-11-01

Reducing pollutants emissions while keeping a high combustion efficiency and a low fuel consumption is an important challenge for both gas turbine (GT) and internal combustion engines (ICE). To fulfill these new constraints, stratified combustion may constitute an efficient strategy. A tabulated chemistry approach based on FPI combined to a low-Mach number method is applied in the analysis of a turbulent propane-air flame with equivalence ratio (ER) stratification, which has been studied experimentally by Balusamy [S. Balusamy, Ph.D Thesis, INSA-Rouen (2010)]. Flame topology, along with flame velocity statistics, are well reproduced in the simulation, even if time-history effects are not accounted for in the tabulated approach. However, these effects may become significant when exhaust gas recirculation (EGR) is introduced. To better quantify them, both ER and EGR-stratified two-dimensional flames are simulated using finite-rate chemistry and a semi-detailed mechanism for propane oxidation. The numerical implementation is first investigated in terms of efficiency and accuracy, with a focus on splitting errors. The resulting flames are then analyzed to investigate potential extensions of the FPI technique to EGR stratification.

OVERVIEW OF NEUTRON MEASUREMENTS IN JET FUSION DEVICE.

PubMed

Batistoni, P; Villari, R; Obryk, B; Packer, L W; Stamatelatos, I E; Popovichev, S; Colangeli, A; Colling, B; Fonnesu, N; Loreti, S; Klix, A; Klosowski, M; Malik, K; Naish, J; Pillon, M; Vasilopoulou, T; De Felice, P; Pimpinella, M; Quintieri, L

2017-10-05

The design and operation of ITER experimental fusion reactor requires the development of neutron measurement techniques and numerical tools to derive the fusion power and the radiation field in the device and in the surrounding areas. Nuclear analyses provide essential input to the conceptual design, optimisation, engineering and safety case in ITER and power plant studies. The required radiation transport calculations are extremely challenging because of the large physical extent of the reactor plant, the complexity of the geometry, and the combination of deep penetration and streaming paths. This article reports the experimental activities which are carried-out at JET to validate the neutronics measurements methods and numerical tools used in ITER and power plant design. A new deuterium-tritium campaign is proposed in 2019 at JET: the unique 14 MeV neutron yields produced will be exploited as much as possible to validate measurement techniques, codes, procedures and data currently used in ITER design thus reducing the related uncertainties and the associated risks in the machine operation. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Investigation of finite element: ABC methods for electromagnetic field simulation. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Chatterjee, A.; Volakis, John L.; Nguyen, J.

1994-01-01

The mechanics of wave propagation in the presence of obstacles is of great interest in many branches of engineering and applied mathematics like electromagnetics, fluid dynamics, geophysics, seismology, etc. Such problems can be broadly classified into two categories: the bounded domain or the closed problem and the unbounded domain or the open problem. Analytical techniques have been derived for the simpler problems; however, the need to model complicated geometrical features, complex material coatings and fillings, and to adapt the model to changing design parameters have inevitably tilted the balance in favor of numerical techniques. The modeling of closed problems presents difficulties primarily in proper meshing of the interior region. However, problems in unbounded domains pose a unique challenge to computation, since the exterior region is inappropriate for direct implementation of numerical techniques. A large number of solutions have been proposed but only a few have stood the test of time and experiment. The goal of this thesis is to develop an efficient and reliable partial differential equation technique to model large three dimensional scattering problems in electromagnetics.

Local Orthogonal Cutting Method for Computing Medial Curves and Its Biomedical Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiao, Xiangmin; Einstein, Daniel R.; Dyedov, Volodymyr

2010-03-24

Medial curves have a wide range of applications in geometric modeling and analysis (such as shape matching) and biomedical engineering (such as morphometry and computer assisted surgery). The computation of medial curves poses significant challenges, both in terms of theoretical analysis and practical efficiency and reliability. In this paper, we propose a definition and analysis of medial curves and also describe an efficient and robust method for computing medial curves. Our approach is based on three key concepts: a local orthogonal decomposition of objects into substructures, a differential geometry concept called the interior center of curvature (ICC), and integrated stabilitymore » and consistency tests. These concepts lend themselves to robust numerical techniques including eigenvalue analysis, weighted least squares approximations, and numerical minimization, resulting in an algorithm that is efficient and noise resistant. We illustrate the effectiveness and robustness of our approach with some highly complex, large-scale, noisy biomedical geometries derived from medical images, including lung airways and blood vessels. We also present comparisons of our method with some existing methods.« less

Advances in computational design and analysis of airbreathing propulsion systems

NASA Technical Reports Server (NTRS)

Klineberg, John M.

1989-01-01

The development of commercial and military aircraft depends, to a large extent, on engine manufacturers being able to achieve significant increases in propulsion capability through improved component aerodynamics, materials, and structures. The recent history of propulsion has been marked by efforts to develop computational techniques that can speed up the propulsion design process and produce superior designs. The availability of powerful supercomputers, such as the NASA Numerical Aerodynamic Simulator, and the potential for even higher performance offered by parallel computer architectures, have opened the door to the use of multi-dimensional simulations to study complex physical phenomena in propulsion systems that have previously defied analysis or experimental observation. An overview of several NASA Lewis research efforts is provided that are contributing toward the long-range goal of a numerical test-cell for the integrated, multidisciplinary design, analysis, and optimization of propulsion systems. Specific examples in Internal Computational Fluid Mechanics, Computational Structural Mechanics, Computational Materials Science, and High Performance Computing are cited and described in terms of current capabilities, technical challenges, and future research directions.

Decellularized material as scaffolds for tissue engineering studies in long gap esophageal atresia.

PubMed

Lee, Esmond; Milan, Anna; Urbani, Luca; De Coppi, Paolo; Lowdell, Mark W

2017-05-01

Esophageal atresia refers to an anomaly in foetal development in which the esophagus terminates in a blind end. Whilst surgical correction is achievable in most patients, when a long gap is present it still represents a major challenge associated with higher morbidity and mortality. In this context, tissue engineering could represent a successful alternative to restore oesophageal function and structure. Naturally derived biomaterials made of decellularized tissues retain native extracellular matrix architecture and composition, providing a suitable bed for the anchorage and growth of relevant cell types. Areas covered: This review outlines the various strategies and challenges in esophageal tissue engineering, highlighting the evolution of ideas in the development of decellularized scaffolds for clinical use. It explores the interplay between clinical needs, ethical dilemmas, and manufacturing challenges in the development of a tissue engineered decellularized scaffold for oesophageal atresia. Expert opinion: Current progress on oesophageal tissue engineering has enabled effective repair of patch defects, whilst the development of a full circumferential construct remains a challenge. Despite the different approaches available and the improvements achieved, a gold standard for fully functional tissue engineered oesophageal constructs has not been defined yet.

Linde FUSRAP Site Remediation: Engineering Challenges and Solutions of Remedial Activities on an Active Industrial Facility - 13506

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beres, Christopher M.; Fort, E. Joseph; Boyle, James D.

2013-07-01

The Linde FUSRAP Site (Linde) is located in Tonawanda, New York at a major research and development facility for Praxair, Inc. (Praxair). Successful remediation activities at Linde combines meeting cleanup objectives of radiological contamination while minimizing impacts to Praxair business operations. The unique use of Praxair's property coupled with an array of active and abandoned utilities poses many engineering and operational challenges; each of which has been overcome during the remedial action at Linde. The U.S. Army Corps of Engineers - Buffalo District (USACE) and CABRERA SERVICES, INC. (CABRERA) have successfully faced engineering challenges such as relocation of an abovegroundmore » structure, structural protection of an active water line, and installation of active mechanical, electrical, and communication utilities to perform remediation. As remediation nears completion, continued success of engineering challenges is critical as remaining activities exist in the vicinity of infrastructure essential to business operations; an electrical substation and duct bank providing power throughout the Praxair facility. Emphasis on engineering and operations through final remediation and into site restoration will allow for the safe and successful completion of the project. (authors)« less

Representation and misrepresentation: Tufte and the Morton Thiokol engineers on the Challenger.

PubMed

Robison, Wade; Boisjoly, Roger; Hoeker, David; Young, Stefan

2002-01-01

This paper examines the role of the Morton Thiokol engineers in the decisions surrounding the launch of the Challenger, particularly with reference to an analysis of this event by Edward Tufte. The engineers at Morton Thiokol recommended against the launch of Challenger because the projected launch temperature between 26 degrees F to 29 degrees F was far outside their field database of successful launches. The engineers had asked for, but not received, data necessary to determine the cause of massive blow-by on the launch the previous January, and they had informed their managers and NASA that continuing flights could be catastrophic if the cause of the problems with the launches was not discovered. The authors conclude that the engineers thus did what they were ethically as well as professionally obligated to do.

Numerical methods in heat transfer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, R.W.

1985-01-01

This third volume in the series in Numerical Methods in Engineering presents expanded versions of selected papers given at the Conference on Numerical Methods in Thermal Problems held in Venice in July 1981. In this reference work, contributors offer the current state of knowledge on the numerical solution of convective heat transfer problems and conduction heat transfer problems.

DEVELOPMENTS IN GRworkbench

NASA Astrophysics Data System (ADS)

Moylan, Andrew; Scott, Susan M.; Searle, Anthony C.

2006-02-01

The software tool GRworkbench is an ongoing project in visual, numerical General Relativity at The Australian National University. Recently, GRworkbench has been significantly extended to facilitate numerical experimentation in analytically-defined space-times. The numerical differential geometric engine has been rewritten using functional programming techniques, enabling objects which are normally defined as functions in the formalism of differential geometry and General Relativity to be directly represented as function variables in the C++ code of GRworkbench. The new functional differential geometric engine allows for more accurate and efficient visualisation of objects in space-times and makes new, efficient computational techniques available. Motivated by the desire to investigate a recent scientific claim using GRworkbench, new tools for numerical experimentation have been implemented, allowing for the simulation of complex physical situations.

High Resolution Numerical Simulations of Primary Atomization in Diesel Sprays with Single Component Reference Fuels

DTIC Science & Technology

2015-09-01

NC. 14. ABSTRACT A high-resolution numerical simulation of jet breakup and spray formation from a complex diesel fuel injector at diesel engine... diesel fuel injector at diesel engine type conditions has been performed. A full understanding of the primary atomization process in diesel fuel... diesel liquid sprays the complexity is further compounded by the physical attributes present including nozzle turbulence, large density ratios

Influence of Alternative Engine Concepts on LCTR2 Sizing and Mission Profile

DTIC Science & Technology

2012-01-01

II), and engine performance was estimated with the Numerical Propulsion System Simulation ( NPSS ). Design trades for the ACE vs. VSPT are presented...Maximum Continuous Power MRP Maximum Rated Power (take-off power) NDARC NASA Design and Analysis of Rotorcraft NPSS Numerical Propulsion System...System Simulation ( NPSS ). Design trades for the ACE vs. VSPT are presented in terms of vehicle weight empty for variations in mission altitude and

DNA-mediated engineering of multicomponent enzyme crystals

PubMed Central

Brodin, Jeffrey D.; Auyeung, Evelyn; Mirkin, Chad A.

2015-01-01

The ability to predictably control the coassembly of multiple nanoscale building blocks, especially those with disparate chemical and physical properties such as biomolecules and inorganic nanoparticles, has far-reaching implications in catalysis, sensing, and photonics, but a generalizable strategy for engineering specific contacts between these particles is an outstanding challenge. This is especially true in the case of proteins, where the types of possible interparticle interactions are numerous, diverse, and complex. Herein, we explore the concept of trading protein–protein interactions for DNA–DNA interactions to direct the assembly of two nucleic-acid–functionalized proteins with distinct surface chemistries into six unique lattices composed of catalytically active proteins, or of a combination of proteins and DNA-modified gold nanoparticles. The programmable nature of DNA–DNA interactions used in this strategy allows us to control the lattice symmetries and unit cell constants, as well as the compositions and habit, of the resulting crystals. This study provides a potentially generalizable strategy for constructing a unique class of materials that take advantage of the diverse morphologies, surface chemistries, and functionalities of proteins for assembling functional crystalline materials. PMID:25831510

DNA-mediated engineering of multicomponent enzyme crystals

DOE PAGES

Brodin, Jeffrey D.; Auyeung, Evelyn; Mirkin, Chad A.

2015-03-23

The ability to predictably control the coassembly of multiple nanoscale building blocks, especially those with disparate chemical and physical properties such as biomolecules and inorganic nanoparticles, has far-reaching implications in catalysis, sensing, and photonics, but a generalizable strategy for engineering specific contacts between these particles is an outstanding challenge. This is especially true in the case of proteins, where the types of possible interparticle interactions are numerous, diverse, and complex. In this paper, we explore the concept of trading protein–protein interactions for DNA–DNA interactions to direct the assembly of two nucleic-acid–functionalized proteins with distinct surface chemistries into six unique latticesmore » composed of catalytically active proteins, or of a combination of proteins and DNA-modified gold nanoparticles. The programmable nature of DNA–DNA interactions used in this strategy allows us to control the lattice symmetries and unit cell constants, as well as the compositions and habit, of the resulting crystals. Finally, this study provides a potentially generalizable strategy for constructing a unique class of materials that take advantage of the diverse morphologies, surface chemistries, and functionalities of proteins for assembling functional crystalline materials.« less

2001 NASA Seal/secondary Air System Workshop, Volume 1. Volume 1

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M. (Editor); Hendricks, Robert C. (Editor)

2002-01-01

The 2001 NASA Seal/Secondary Air System Workshop covered the following topics: (i) overview of NASA's Vision for 21st Century Aircraft; (ii) overview of NASA-sponsored Ultra-Efficient Engine Technology (UEET); (iii) reviews of sealing concepts, test results, experimental facilities, and numerical predictions; and (iv) reviews of material development programs relevant to advanced seals development. The NASA UEET overview illustrates for the reader the importance of advanced technologies, including seals, in meeting future turbine engine system efficiency and emission goals. The NASA UEET program goals include an 8-to 15-percent reduction in fuel burn, a 15-percent reduction in CO2, a 70-percent reduction in NOx, CO, and unburned hydrocarbons, and a 30-dB noise reduction relative to program baselines. The workshop also covered several programs NASA is funding to investigate advanced reusable space vehicle technologies (X-38) and advanced space ram/scramjet propulsion systems. Seal challenges posed by these advanced systems include high-temperature operation, resiliency at the operating temperature to accommodate sidewall flexing, and durability to last many missions.

Advanced Combustion Numerics and Modeling - FY18 First Quarter Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whitesides, R. A.; Killingsworth, N. J.; McNenly, M. J.

This project is focused on early stage research and development of numerical methods and models to improve advanced engine combustion concepts and systems. The current focus is on development of new mathematics and algorithms to reduce the time to solution for advanced combustion engine design using detailed fuel chemistry. The research is prioritized towards the most time-consuming workflow bottlenecks (computer and human) and accuracy gaps that slow ACS program members. Zero-RK, the fast and accurate chemical kinetics solver software developed in this project, is central to the research efforts and continues to be developed to address the current and emergingmore » needs of the engine designers, engine modelers and fuel mechanism developers.« less

Pumping Performance or RBCC Engine under Sea Level Static Condition

NASA Astrophysics Data System (ADS)

Kouchi, Toshinori; Tomioka, Sadatake; Kanda, Takeshi

Numerical simulations were conducted to predict the ejector pumping performance of a rocket-ramjet combined-cycle engine under a take-off condition. The numerical simulations revealed that the suction airflow was chocked at the exit of the engine throat when the ejector rocket was driven by cold N2 gas at the chamber pressure of 3MPa. When the ejector-driving gas was changed from cold N2 gas to hot combustion gas, the suction performance decreased remarkably. Mach contours in the engine revealed that the rocket plume constricted when the driving gas was the hot combustion gas. The change of the area of the stream tube area seemed to induce the pressure rise in the duct and decreasing in the pumping performance.

Responsible authorship in engineering fields: an overview of current ethical challenges.

PubMed

Borenstein, Jason

2011-06-01

The primary aim of this article is to identify ethical challenges relating to authorship in engineering fields. Professional organizations and journals do provide crucial guidance in this realm, but this cannot replace the need for frequent and diligent discussions in engineering research communities about what constitutes appropriate authorship practice. Engineering researchers should seek to identify and address issues such as who is entitled to be an author and whether publishing their research could potentially harm the public.

The logics of metabolic regulation in bacteria challenges biosensor-based metabolic engineering.

PubMed

Jules, Matthieu

2017-12-11

Synthetic Biology (SB) aims at the rational design and engineering of novel biological functions and systems. By facilitating the engineering of living organisms, SB promises to facilitate the development of many new applications for health, biomanufacturing, and the environment. Over the last decade, SB promoted the construction of libraries of components enabling the fine-tuning of genetic circuits expression and the development of novel genome engineering methodologies for many organisms of interest. SB thus opened new perspectives in the field of metabolic engineering, which was until then mainly limited to (over)producing naturally synthesized metabolic compounds. To engineer efficient cell factories, it is key to precisely reroute cellular resources from the central carbon metabolism (CCM) to the synthetic circuitry. This task is however difficult as there is still significant lack of knowledge regarding both the function of several metabolic components and the regulation of the CCM fluxes for many industrially important bacteria. Pyruvate is a pivotal metabolite at the heart of the CCM and a key precursor for the synthesis of several commodity compounds and fine chemicals. Numerous bacterial species can also use it as a carbon source when present in the environment but bacterial, pyruvate-specific uptake systems were to be discovered. This is an issue for metabolic engineering as one can imagine to make use of pyruvate transport systems to replenish synthetic metabolic pathways towards the synthesis of chemicals of interest. Here we describe a recent study (MBio 8(5): e00976-17), which identified and characterized a pyruvate transport system in the Gram-positive (G +ve ) bacterium Bacillus subtilis , a well-established biotechnological workhorse for the production of enzymes, fine chemicals and antibiotics. This study also revealed that the activity of the two-component system (TCS) responsible for its induction is retro-inhibited by the level of pyruvate influx. Following up on the open question which is whether this retro-inhibition is a generic mechanism for TCSs, we will discuss the implications in metabolic engineering.

Qualitative and temporal reasoning in engine behavior analysis

NASA Technical Reports Server (NTRS)

Dietz, W. E.; Stamps, M. E.; Ali, M.

1987-01-01

Numerical simulation models, engine experts, and experimental data are used to generate qualitative and temporal representations of abnormal engine behavior. Engine parameters monitored during operation are used to generate qualitative and temporal representations of actual engine behavior. Similarities between the representations of failure scenarios and the actual engine behavior are used to diagnose fault conditions which have already occurred, or are about to occur; to increase the surveillance by the monitoring system of relevant engine parameters; and to predict likely future engine behavior.

Structural characterization of UHPC waffle bridge deck and connections.

DOT National Transportation Integrated Search

2014-07-01

The AASHTO strategic plan in 2005 for bridge engineering identified extending the service life of bridges and accelerating bridge : construction as two of the grand challenges in bridge engineering. These challenges have the objective of producing sa...

Numerical simulation of the flow about the F-18 HARV at high angle of attack

NASA Technical Reports Server (NTRS)

Murman, Scott M.

1994-01-01

This report summarizes research done over the past two years as part of NASA Grant NCC 2-729. This research has been aimed at validating numerical methods for computing the flow about the complete F-18 HARV at alpha = 30 deg and alpha = 45 deg. At 30 deg angle of attack, the flow about the F-18 is dominated by the formation, and subsequent breakdown, of strong vortices over the wing leading-edge extensions (LEX). As the angle of attack is increased to alpha = 45 deg, the fuselage forebody of the F-18 contains significant laminar and transitional regions which are not present at alpha = 30 deg. Further, the flow over the LEX at alpha = 45 deg is dominated by an unsteady shedding in time, rather than strong coherent vortices. This complex physics, combined with the complex geometry of a full aircraft configuration, provides a challenge for current computational fluid dynamics (CFD) techniques. The following sections present the numerical method and grid generation scheme that was used, a review of prior research done to numerically model the F-18 HARV, and a discussion of the current research. The current research is broken into two main topics: the effect of engine-inlet mass-flow rate on the F-18 vortex breakdown position, and the results using a refined F-18 computational model to compute the flow at alpha = 30 deg and alpha = 45 deg.

Numerical simulation of the flow about the F-18 HARV at high angle of attack

NASA Technical Reports Server (NTRS)

Murman, Scott M.

1995-01-01

This research has been aimed at validating numerical methods for computing the flow about the complete F-18 HARV at alpha = 30 deg and alpha = 45 deg. At 30 deg angle of attack, the flow about the F-18 is dominated by the formation, and subsequent breakdown, of strong vortices over the wing leading-edge extensions (LEX). As the angle of attack is increased to alpha = 45 deg, the fuselage forebody of the F-18 contains significant laminar and transitional regions which are not present at alpha = 30 deg. Further, the flow over the LEX at alpha = 45 deg is dominated by an unsteady shedding in time, rather than strong coherent vortices. This complex physics, combined with the complex geometry of a full-aircraft configuration, provides a challenge for current computational fluid dynamics (CFD) techniques. The following sections present the numerical method and grid generation scheme that was used, a review of prior research done to numerically model the F-18 HARV, and a discussion of the current research. The current research is broken into three main topics; the effect of engine-inlet mass-flow rate on the F-18 vortex breakdown position, the results using a refined F-18 computational model to compute the flow at alpha = 30 deg and alpha = 45 deg, and research done using the simplified geometry of an ogive-cylinder configuration to investigate the physics of unsteady shear-layer shedding. The last section briefly summarizes the discussion.

3D engineered models for highway construction : the Iowa experience.

DOT National Transportation Integrated Search

2015-06-01

3D engineered modeling is a relatively new and developing technology that can provide numerous bene ts to owners, engineers, : contractors, and the general public. This manual is for highway agencies that are considering or are in the process of s...

Testing Scientific Software: A Systematic Literature Review.

PubMed

Kanewala, Upulee; Bieman, James M

2014-10-01

Scientific software plays an important role in critical decision making, for example making weather predictions based on climate models, and computation of evidence for research publications. Recently, scientists have had to retract publications due to errors caused by software faults. Systematic testing can identify such faults in code. This study aims to identify specific challenges, proposed solutions, and unsolved problems faced when testing scientific software. We conducted a systematic literature survey to identify and analyze relevant literature. We identified 62 studies that provided relevant information about testing scientific software. We found that challenges faced when testing scientific software fall into two main categories: (1) testing challenges that occur due to characteristics of scientific software such as oracle problems and (2) testing challenges that occur due to cultural differences between scientists and the software engineering community such as viewing the code and the model that it implements as inseparable entities. In addition, we identified methods to potentially overcome these challenges and their limitations. Finally we describe unsolved challenges and how software engineering researchers and practitioners can help to overcome them. Scientific software presents special challenges for testing. Specifically, cultural differences between scientist developers and software engineers, along with the characteristics of the scientific software make testing more difficult. Existing techniques such as code clone detection can help to improve the testing process. Software engineers should consider special challenges posed by scientific software such as oracle problems when developing testing techniques.

Design Challenges Encountered in a Propulsion-Controlled Aircraft Flight Test Program

NASA Technical Reports Server (NTRS)

Maine, Trindel; Burken, John; Burcham, Frank; Schaefer, Peter

1994-01-01

The NASA Dryden Flight Research Center conducted flight tests of a propulsion-controlled aircraft system on an F-15 airplane. This system was designed to explore the feasibility of providing safe emergency landing capability using only the engines to provide flight control in the event of a catastrophic loss of conventional flight controls. Control laws were designed to control the flightpath and bank angle using only commands to the throttles. Although the program was highly successful, this paper highlights some of the challenges associated with using engine thrust as a control effector. These challenges include slow engine response time, poorly modeled nonlinear engine dynamics, unmodeled inlet-airframe interactions, and difficulties with ground effect and gust rejection. Flight and simulation data illustrate these difficulties.

Mars Reconnaissance Orbiter Mission: Systems Engineering Challenges on the Mars Reconnaissance Orbiter Mission

NASA Technical Reports Server (NTRS)

Havens, Glen G.

2007-01-01

MRO project is a system of systems requiring system engineering team to architect, design, integrate, test, and operate these systems at each level of the project. The challenge of system engineering mission objectives into a single mission architecture that can be integrated tested, launched, and operated. Systems engineering must translate high-level requirements into integrated mission design. Systems engineering challenges were overcome utilizing a combination by creative designs built into MRO's flight and ground systems: a) Design of sophisticated spacecraft targeting and data management capabilities b) Establishment of a strong operations team organization; c) Implementation of robust operational processes; and d) Development of strategic ground tools. The MRO system has met the challenge of its driving requirements: a) MRO began its two-year primary science phase on November 7, 2006, and by July 2007, met it minimum requirement to collect 15 Tbits of data after only eight months of operations. Currently we have collected 22 Tbits. b) Based on current performance, mission data return could return 70 Tbits of data by the end of the primary science phase in 2008.

The community FabLab platform: applications and implications in biomedical engineering.

PubMed

Stephenson, Makeda K; Dow, Douglas E

2014-01-01

Skill development in science, technology, engineering and math (STEM) education present one of the most formidable challenges of modern society. The Community FabLab platform presents a viable solution. Each FabLab contains a suite of modern computer numerical control (CNC) equipment, electronics and computing hardware and design, programming, computer aided design (CAD) and computer aided machining (CAM) software. FabLabs are community and educational resources and open to the public. Development of STEM based workforce skills such as digital fabrication and advanced manufacturing can be enhanced using this platform. Particularly notable is the potential of the FabLab platform in STEM education. The active learning environment engages and supports a diversity of learners, while the iterative learning that is supported by the FabLab rapid prototyping platform facilitates depth of understanding, creativity, innovation and mastery. The product and project based learning that occurs in FabLabs develops in the student a personal sense of accomplishment, self-awareness, command of the material and technology. This helps build the interest and confidence necessary to excel in STEM and throughout life. Finally the introduction and use of relevant technologies at every stage of the education process ensures technical familiarity and a broad knowledge base needed for work in STEM based fields. Biomedical engineering education strives to cultivate broad technical adeptness, creativity, interdisciplinary thought, and an ability to form deep conceptual understanding of complex systems. The FabLab platform is well designed to enhance biomedical engineering education.

Isoprenoid drugs, biofuels, and chemicals--artemisinin, farnesene, and beyond.

PubMed

George, Kevin W; Alonso-Gutierrez, Jorge; Keasling, Jay D; Lee, Taek Soon

2015-01-01

Isoprenoids have been identified and used as natural pharmaceuticals, fragrances, solvents, and, more recently, advanced biofuels. Although isoprenoids are most commonly found in plants, researchers have successfully engineered both the eukaryotic and prokaryotic isoprenoid biosynthetic pathways to produce these valuable chemicals in microorganisms at high yields. The microbial synthesis of the precursor to artemisinin--an important antimalarial drug produced from the sweet wormwood Artemisia annua--serves as perhaps the most successful example of this approach. Through advances in synthetic biology and metabolic engineering, microbial-derived semisynthetic artemisinin may soon replace plant-derived artemisinin as the primary source of this valuable pharmaceutical. The richness and diversity of isoprenoid structures also make them ideal candidates for advanced biofuels that may act as "drop-in" replacements for gasoline, diesel, and jet fuel. Indeed, the sesquiterpenes farnesene and bisabolene, monoterpenes pinene and limonene, and hemiterpenes isopentenol and isopentanol have been evaluated as fuels or fuel precursors. As in the artemisinin project, these isoprenoids have been produced microbially through synthetic biology and metabolic engineering efforts. Here, we provide a brief review of the numerous isoprenoid compounds that have found use as pharmaceuticals, flavors, commodity chemicals, and, most importantly, advanced biofuels. In each case, we highlight the metabolic engineering strategies that were used to produce these compounds successfully in microbial hosts. In addition, we present a current outlook on microbial isoprenoid production, with an eye towards the many challenges that must be addressed to achieve higher yields and industrial-scale production.

Incorporating neurophysiological concepts in mathematical thermoregulation models

NASA Astrophysics Data System (ADS)

Kingma, Boris R. M.; Vosselman, M. J.; Frijns, A. J. H.; van Steenhoven, A. A.; van Marken Lichtenbelt, W. D.

2014-01-01

Skin blood flow (SBF) is a key player in human thermoregulation during mild thermal challenges. Various numerical models of SBF regulation exist. However, none explicitly incorporates the neurophysiology of thermal reception. This study tested a new SBF model that is in line with experimental data on thermal reception and the neurophysiological pathways involved in thermoregulatory SBF control. Additionally, a numerical thermoregulation model was used as a platform to test the function of the neurophysiological SBF model for skin temperature simulation. The prediction-error of the SBF-model was quantified by root-mean-squared-residual (RMSR) between simulations and experimental measurement data. Measurement data consisted of SBF (abdomen, forearm, hand), core and skin temperature recordings of young males during three transient thermal challenges (1 development and 2 validation). Additionally, ThermoSEM, a thermoregulation model, was used to simulate body temperatures using the new neurophysiological SBF-model. The RMSR between simulated and measured mean skin temperature was used to validate the model. The neurophysiological model predicted SBF with an accuracy of RMSR < 0.27. Tskin simulation results were within 0.37 °C of the measured mean skin temperature. This study shows that (1) thermal reception and neurophysiological pathways involved in thermoregulatory SBF control can be captured in a mathematical model, and (2) human thermoregulation models can be equipped with SBF control functions that are based on neurophysiology without loss of performance. The neurophysiological approach in modelling thermoregulation is favourable over engineering approaches because it is more in line with the underlying physiology.

The European Project Semester at ISEP: the challenge of educating global engineers

NASA Astrophysics Data System (ADS)

Malheiro, Benedita; Silva, Manuel; Ribeiro, Maria Cristina; Guedes, Pedro; Ferreira, Paulo

2015-05-01

Current engineering education challenges require approaches that promote scientific, technical, design and complementary skills while fostering autonomy, innovation and responsibility. The European Project Semester (EPS) at Instituto Superior de Engenharia do Porto (ISEP) (EPS@ISEP) is a one semester project-based learning programme (30 European Credit Transfer Units (ECTU)) for engineering students from diverse scientific backgrounds and nationalities that intends to address these goals. The students, organised in multidisciplinary and multicultural teams, are challenged to solve real multidisciplinary problems during one semester. The EPS package, although on project development (20 ECTU), includes a series of complementary seminars aimed at fostering soft, project-related and engineering transversal skills (10 ECTU). Hence, the students enrolled in this programme improve their transversal skills and learn, together and with the team of supervisors, subjects distinct from their core training. This paper presents the structure, implementation and results of the EPS@ISEP that was created in 2011 to apply the best engineering practices and promote internationalisation and engineering education innovation at ISEP.

Socio-Technical Perspective on Interdisciplinary Interactions During the Development of Complex Engineered Systems

NASA Technical Reports Server (NTRS)

McGowan, Anna-Maria R.; Daly, Shanna; Baker, Wayne; Papalambros, panos; Seifert, Colleen

2013-01-01

This study investigates interdisciplinary interactions that take place during the research, development, and early conceptual design phases in the design of large-scale complex engineered systems (LaCES) such as aerospace vehicles. These interactions, that take place throughout a large engineering development organization, become the initial conditions of the systems engineering process that ultimately leads to the development of a viable system. This paper summarizes some of the challenges and opportunities regarding social and organizational issues that emerged from a qualitative study using ethnographic and survey data. The analysis reveals several socio-technical couplings between the engineered system and the organization that creates it. Survey respondents noted the importance of interdisciplinary interactions and their benefits to the engineered system as well as substantial challenges in interdisciplinary interactions. Noted benefits included enhanced knowledge and problem mitigation and noted obstacles centered on organizational and human dynamics. Findings suggest that addressing the social challenges may be a critical need in enabling interdisciplinary interactions

Emerging hypersonic propulsion technology

NASA Technical Reports Server (NTRS)

Curran, E. T.; Beach, H. L., Jr.

1988-01-01

Currently there is a renewal of interest in the utilization of air breathing engines for hypersonic flight. The use of such engines in accelerative missions is discussed, and the nature of the trade-off between engine thrust-to-weight ratio and specific impulse is highlighted. It is also pointed out that the use of a cryogenic fuel such as liquid hydrogen offers the opportunity to develop both precooled derivatives of turboaccelerator engines and new cryogenic engine cycles, where the heat exchange process plays a significant role in the engine concept. The continuing challenges of developing high speed supersonic combustion ramjet engines are discussed. The paper concludes with a brief review of the difficult discipline of vehicle integration, and the challenges of both ground and flight testing.

Numerical Modelling of Ground Penetrating Radar Antennas

NASA Astrophysics Data System (ADS)

Giannakis, Iraklis; Giannopoulos, Antonios; Pajewski, Lara

2014-05-01

Numerical methods are needed in order to solve Maxwell's equations in complicated and realistic problems. Over the years a number of numerical methods have been developed to do so. Amongst them the most popular are the finite element, finite difference implicit techniques, frequency domain solution of Helmontz equation, the method of moments, transmission line matrix method. However, the finite-difference time-domain method (FDTD) is considered to be one of the most attractive choice basically because of its simplicity, speed and accuracy. FDTD first introduced in 1966 by Kane Yee. Since then, FDTD has been established and developed to be a very rigorous and well defined numerical method for solving Maxwell's equations. The order characteristics, accuracy and limitations are rigorously and mathematically defined. This makes FDTD reliable and easy to use. Numerical modelling of Ground Penetrating Radar (GPR) is a very useful tool which can be used in order to give us insight into the scattering mechanisms and can also be used as an alternative approach to aid data interpretation. Numerical modelling has been used in a wide range of GPR applications including archeology, geophysics, forensic, landmine detection etc. In engineering, some applications of numerical modelling include the estimation of the effectiveness of GPR to detect voids in bridges, to detect metal bars in concrete, to estimate shielding effectiveness etc. The main challenges in numerical modelling of GPR for engineering applications are A) the implementation of the dielectric properties of the media (soils, concrete etc.) in a realistic way, B) the implementation of the geometry of the media (soils inhomogeneities, rough surface, vegetation, concrete features like fractures and rock fragments etc.) and C) the detailed modelling of the antenna units. The main focus of this work (which is part of the COST Action TU1208) is the accurate and realistic implementation of GPR antenna units into the FDTD model. Accurate models based on general characteristics of the commercial antennas GSSI 1.5 GHz and MALA 1.2 GHz have been already incorporated in GprMax, a free software which solves Maxwell's equation using a second order in space and time FDTD algorithm. This work presents the implementation of horn antennas with different parameters as well as ridged horn antennas into this FDTD model and their effectiveness is tested in realistic modelled situations. Accurate models of soils and concrete are used to test and compare different antenna units. Stochastic methods are used in order to realistically simulate the geometrical characteristics of the medium. Regarding the dielectric properties, Debye approximations are incorporated in order to simulate realistically the dielectric properties of the medium on the frequency range of interest.

Research on numerical simulation and protection of transient process in long-distance slurry transportation pipelines

NASA Astrophysics Data System (ADS)

Lan, G.; Jiang, J.; Li, D. D.; Yi, W. S.; Zhao, Z.; Nie, L. N.

2013-12-01

The calculation of water-hammer pressure phenomenon of single-phase liquid is already more mature for a pipeline of uniform characteristics, but less research has addressed the calculation of slurry water hammer pressure in complex pipelines with slurry flows carrying solid particles. In this paper, based on the developments of slurry pipelines at home and abroad, the fundamental principle and method of numerical simulation of transient processes are presented, and several boundary conditions are given. Through the numerical simulation and analysis of transient processes of a practical engineering of long-distance slurry transportation pipeline system, effective protection measures and operating suggestions are presented. A model for calculating the water impact of solid and fluid phases is established based on a practical engineering of long-distance slurry pipeline transportation system. After performing a numerical simulation of the transient process, analyzing and comparing the results, effective protection measures and operating advice are recommended, which has guiding significance to the design and operating management of practical engineering of longdistance slurry pipeline transportation system.

A looped-tube traveling-wave engine with liquid pistons

NASA Astrophysics Data System (ADS)

Hyodo, H.; Tamura, S.; Biwa, T.

2017-09-01

This report describes the operation of a liquid piston engine that uses thermoacoustic spontaneous oscillations of liquid and gas columns connected in series to form a loop. Analysis of the analogous mass-spring model and the numerical calculation based on hydrodynamic equations shows that the natural mode oscillations of the system allow the working gas to execute a Stirling thermodynamic cycle. Numerical results of the operating temperature difference were confirmed from experimentally obtained results.

Ultrasonic Vibration Assisted Grinding of Bio-ceramic Materials: Modeling, Simulation, and Experimental Investigations on Edge Chipping

NASA Astrophysics Data System (ADS)

Tesfay, Hayelom D.

Bio-ceramics are those engineered materials that find their applications in the field of biomedical engineering or medicine. They have been widely used in dental restorations, repairing bones, joint replacements, pacemakers, kidney dialysis machines, and respirators. etc. due to their physico-chemical properties, such as excellent corrosion resistance, good biocompatibility, high strength and high wear resistance. Because of their inherent brittleness and hardness nature they are difficult to machine to exact sizes and dimensions. Abrasive machining processes such as grinding is one of the most widely used manufacturing processes for bioceramics. However, the principal technical challenge resulted from these machining is edge chipping. Edge chipping is a common edge failure commonly observed during the machining of bio-ceramic materials. The presence of edge chipping on bio-ceramic products affects dimensional accuracy, increases manufacturing cost, hider their industrial applications and causes potential failure during service. To overcome these technological challenges, a new ultrasonic vibration-assisted grinding (UVAG) manufacturing method has been developed and employed in this research. The ultimate aim of this study is to develop a new cost-effective manufacturing process relevant to eliminate edge chippings in grinding of bio-ceramic materials. In this dissertation, comprehensive investigations will be carried out using experimental, theoretical, and numerical approaches to evaluate the effect of ultrasonic vibrations on edge chipping of bioceramics. Moreover, effects of nine input variables (static load, vibration frequency, grinding depth, spindle speed, grinding distance, tool speed, grain size, grain number, and vibration amplitude) on edge chipping will be studied based on the developed models. Following a description of previous research and existing approaches, a series of experimental tests on three bio-ceramic materials (Lava, partially fired Lava, and Alumina) were conducted. Based on the experimental results, analytical models for UVAG and CG (conventional grinding without ultrasonic vibration) processes were developed. As for the numerical study, an extended finite element method (XFEM) based on Virtual Crack Closure Technique (VCCT) in ABAQUS was used to model the formation of edge chippings both for UVAG and CG processes. The experimental results are compared against the numerical FEA and the analytical models. The experimental, theoretical, and computational simulation results revealed that the edge chipping size of bioceramics can be significantly reduced with the assistance of ultrasonic vibration. The investigation procedures and the results obtained in this dissertation would be used as a reference and practical guidance for choosing reasonable process variables as well as designing mathematical (analytical and numerical) models in manufacturing industries and academic institutions when the edge chippings of brittle materials are expected to be controlled.

Nozzle Numerical Analysis Of The Scimitar Engine

NASA Astrophysics Data System (ADS)

Battista, F.; Marini, M.; Cutrone, L.

2011-05-01

This work describes part of the activities on the LAPCAT-II A2 vehicle, in which starting from the available conceptual vehicle design and the related pre- cooled turbo-ramjet engine called SCIMITAR, well- thought assumptions made for performance figures of different components during the iteration process within LAPCAT-I will be assessed in more detail. In this paper it is presented a numerical analysis aimed at the design optimization of the nozzle contour of the LAPCAT A2 SCIMITAR engine designed by Reaction Engines Ltd. (REL) (see Figure 1). In particular, nozzle shape optimization process is presented for cruise conditions. All the computations have been carried out by using the CIRA C3NS code in non equilibrium conditions. The effect of considering detailed or reduced chemical kinetic schemes has been analyzed with a particular focus on the production of pollutants. An analysis of engine performance parameters, such as thrust and combustion efficiency has been carried out.

Increasing Retention of Women in Engineering at WSU: A Model for a Women's Mentoring Program

ERIC Educational Resources Information Center

Poor, Cara J.; Brown, Shane

2013-01-01

Concerns with the retention of women in engineering have led to the implementation of numerous programs to improve retention, including mentoring programs. The college of engineering at Washington State University (WSU) started a novel women's mentoring program in 2008, using professional engineers who graduated from WSU as mentors. The program is…

Globalization and Organizational Change: Engineers' Experiences and Their Implications for Engineering Education

ERIC Educational Resources Information Center

Lucena, Juan C.

2006-01-01

The demand for flexible engineers presents significant challenges to engineering education. Among these is the need for engineers to be prepared to understand and deal with organizational change. Yet engineering education and research on engineers have overlooked the impact of organizational change on engineering work. After outlining the impact…

Cumulative reports and publications through December 31, 1989

NASA Technical Reports Server (NTRS)

1990-01-01

A complete list of reports from the Institute for Computer Applications in Science and Engineering (ICASE) is presented. The major categories of the current ICASE research program are: numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; control and parameter identification problems, with emphasis on effectual numerical methods; computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, structural analysis, and chemistry; computer systems and software, especially vector and parallel computers, microcomputers, and data management. Since ICASE reports are intended to be preprints of articles that will appear in journals or conference proceedings, the published reference is included when it is available.

Numerical simulation of synthesis gas incineration

NASA Astrophysics Data System (ADS)

Kazakov, A. V.; Khaustov, S. A.; Tabakaev, R. B.; Belousova, Y. A.

2016-04-01

The authors have analysed the expediency of the suggested low-grade fuels application method. Thermal processing of solid raw materials in the gaseous fuel, called synthesis gas, is investigated. The technical challenges concerning the applicability of the existing gas equipment developed and extensively tested exclusively for natural gas were considered. For this purpose computer simulation of three-dimensional syngas-incinerating flame dynamics was performed by means of the ANSYS Multiphysics engineering software. The subjects of studying were: a three-dimensional aerodynamic flame structure, heat-release and temperature fields, a set of combustion properties: a flare range and the concentration distribution of burnout reagents. The obtained results were presented in the form of a time-averaged pathlines with color indexing. The obtained results can be used for qualitative and quantitative evaluation of complex multicomponent gas incineration singularities.

Technological Innovations from NASA

NASA Technical Reports Server (NTRS)

Pellis, Neal R.

2006-01-01

The challenge of human space exploration places demands on technology that push concepts and development to the leading edge. In biotechnology and biomedical equipment development, NASA science has been the seed for numerous innovations, many of which are in the commercial arena. The biotechnology effort has led to rational drug design, analytical equipment, and cell culture and tissue engineering strategies. Biomedical research and development has resulted in medical devices that enable diagnosis and treatment advances. NASA Biomedical developments are exemplified in the new laser light scattering analysis for cataracts, the axial flow left ventricular-assist device, non contact electrocardiography, and the guidance system for LASIK surgery. Many more developments are in progress. NASA will continue to advance technologies, incorporating new approaches from basic and applied research, nanotechnology, computational modeling, and database analyses.

Comparative genomics approaches to understanding and manipulating plant metabolism.

PubMed

Bradbury, Louis M T; Niehaus, Tom D; Hanson, Andrew D

2013-04-01

Over 3000 genomes, including numerous plant genomes, are now sequenced. However, their annotation remains problematic as illustrated by the many conserved genes with no assigned function, vague annotations such as 'kinase', or even wrong ones. Around 40% of genes of unknown function that are conserved between plants and microbes are probably metabolic enzymes or transporters; finding functions for these genes is a major challenge. Comparative genomics has correctly predicted functions for many such genes by analyzing genomic context, and gene fusions, distributions and co-expression. Comparative genomics complements genetic and biochemical approaches to dissect metabolism, continues to increase in power and decrease in cost, and has a pivotal role in modeling and engineering by helping identify functions for all metabolic genes. Copyright © 2012 Elsevier Ltd. All rights reserved.

Gamma-ray burst jet dynamics and their interaction with the progenitor star.

PubMed

Lazzati, Davide; Morsony, Brian J; Begelman, Mitchell C

2007-05-15

The association of at least some long gamma-ray bursts with type Ic supernova explosions has been established beyond reasonable doubt. Theoretically, the challenge is to explain the presence of a light hyper-relativistic flow propagating through a massive stellar core without losing those properties. We discuss the role of the jet-star interaction in shaping the properties of the outflow emerging on the surface of the star. We show that the nature of the inner engine is hidden from the observer for most of the evolution, well beyond the time of the jet breakout on the stellar surface. The discussion is based on analytical considerations as well as high resolution numerical simulations. Finally, the observational consequences of the scenario are addressed in light of the present capabilities.

Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing.

PubMed

Chakravarti, Deboki; Cho, Jang Hwan; Weinberg, Benjamin H; Wong, Nicole M; Wong, Wilson W

2016-04-18

Investigations into cells and their contents have provided evolving insight into the emergence of complex biological behaviors. Capitalizing on this knowledge, synthetic biology seeks to manipulate the cellular machinery towards novel purposes, extending discoveries from basic science to new applications. While these developments have demonstrated the potential of building with biological parts, the complexity of cells can pose numerous challenges. In this review, we will highlight the broad and vital role that the synthetic biology approach has played in applying fundamental biological discoveries in receptors, genetic circuits, and genome-editing systems towards translation in the fields of immunotherapy, biosensors, disease models and gene therapy. These examples are evidence of the strength of synthetic approaches, while also illustrating considerations that must be addressed when developing systems around living cells.

An image engineering system for the inspection of transparent construction materials

NASA Astrophysics Data System (ADS)

Hinz, S.; Stephani, M.; Schiemann, L.; Zeller, K.

This article presents a modular photogrammetric recording and image analysis system for inspecting the material characteristics of transparent foils, in particular Ethylen-TetraFluorEthylen-Copolymer (ETFE) foils. The foils are put under increasing air pressure and are observed by a stereo camera system. Determining the time-variable 3D shape of transparent material imposes a number of challenges: especially the automatic point transfer between stereo images and, in temporal domain, from one image pair to the next. We developed an automatic approach that accommodates for these particular circumstances and allows reconstruction of the 3D shape for each epoch as well as determining 3D translation vectors between epochs by feature tracking. Examples including numerical results and accuracy measures prove the applicability of the system.

Aspects of Unstructured Grids and Finite-Volume Solvers for the Euler and Navier-Stokes Equations

NASA Technical Reports Server (NTRS)

Barth, Timothy J.

1992-01-01

One of the major achievements in engineering science has been the development of computer algorithms for solving nonlinear differential equations such as the Navier-Stokes equations. In the past, limited computer resources have motivated the development of efficient numerical schemes in computational fluid dynamics (CFD) utilizing structured meshes. The use of structured meshes greatly simplifies the implementation of CFD algorithms on conventional computers. Unstructured grids on the other hand offer an alternative to modeling complex geometries. Unstructured meshes have irregular connectivity and usually contain combinations of triangles, quadrilaterals, tetrahedra, and hexahedra. The generation and use of unstructured grids poses new challenges in CFD. The purpose of this note is to present recent developments in the unstructured grid generation and flow solution technology.

Principles of thermoacoustic energy harvesting

NASA Astrophysics Data System (ADS)

Avent, A. W.; Bowen, C. R.

2015-11-01

Thermoacoustics exploit a temperature gradient to produce powerful acoustic pressure waves. The technology has a key role to play in energy harvesting systems. A time-line in the development of thermoacoustics is presented from its earliest recorded example in glass blowing through to the development of the Sondhauss and Rijke tubes to Stirling engines and pulse-tube cryo-cooling. The review sets the current literature in context, identifies key publications and promising areas of research. The fundamental principles of thermoacoustic phenomena are explained; design challenges and factors influencing efficiency are explored. Thermoacoustic processes involve complex multi-physical coupling and transient, highly non-linear relationships which are computationally expensive to model; appropriate numerical modelling techniques and options for analyses are presented. Potential methods of harvesting the energy in the acoustic waves are also examined.

Plasmonic gold nanostars as optical nano-additives for injection molded polymer composites

NASA Astrophysics Data System (ADS)

Boyne, Devon A.; Orlicki, Joshua A.; Walck, Scott D.; Savage, Alice M.; Li, Thomas; Griep, Mark H.

2017-10-01

Nanoscale engineering of noble metal particles has provided numerous material configurations to selectively confine and manipulate light across the electromagnetic spectrum. Transitioning these materials to a composite form while maintaining the desired resonance properties has proven challenging. In this work, the successful integration of plasmon-focusing gold nanostars (GNSs) into polymer nanocomposites (PNCs) is demonstrated. Tailored GNSs are produced with over a 90% yield and methods to control the branching structures are shown. A protective silica capping shell is employed on the nanomaterials to facilitate survivability in the high temperate/high shear processing parameters to create optically-tuned injection molded PNCs. The developed GNS PNCs possess dichroic scattering and absorption behavior, opening up potential applications in the fields of holographic imaging, optical filtering and photovoltaics.

SpicyNodes Radial Map Engine

NASA Astrophysics Data System (ADS)

Douma, M.; Ligierko, G.; Angelov, I.

2008-10-01

The need for information has increased exponentially over the past decades. The current systems for constructing, exploring, classifying, organizing, and searching information face the growing challenge of enabling their users to operate efficiently and intuitively in knowledge-heavy environments. This paper presents SpicyNodes, an advanced user interface for difficult interaction contexts. It is based on an underlying structure known as a radial map, which allows users to manipulate and interact in a natural manner with entities called nodes. This technology overcomes certain limitations of existing solutions and solves the problem of browsing complex sets of linked information. SpicyNodes is also an organic system that projects users into a living space, stimulating exploratory behavior and fostering creative thought. Our interactive radial layout is used for educational purposes and has the potential for numerous other applications.

Modeling the Impact of Fracture Growth on Fluid Displacements in Deformable Porous Media

NASA Astrophysics Data System (ADS)

Santillán, D.; Cueto-Felgueroso, L.; Juanes, R.

2015-12-01

Coupled flow and geomechanics is a critical research challenge in engineering and the geosciences. The flow of a fluid through a deformable porous media is present in manyenvironmental, industrial, and biological processes,such as the removal of pollutants from underground water bodies, enhanced geothermal systems, unconventional hydrocarbon resources or enhanced oil recovery techniques. However, the injection of a fluid can generate or propagate fractures, which are preferential flow paths. Using numerical simulation, we study the interplay between injection and rock mechanics, and elucidate fracture propagation as a function of injection rate, initial crack topology and mechanical rock properties. Finally, we discuss the role of fracture growth on fluid displacements in porous media. Figure: An example of fracture (in red) propagated in a porous media (in blue)

Collaborating with human factors when designing an electronic textbook

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ratner, J.A.; Zadoks, R.I.; Attaway, S.W.

The development of on-line engineering textbooks presents new challenges to authors to effectively integrate text and tools in an electronic environment. By incorporating human factors principles of interface design and cognitive psychology early in the design process, a team at Sandia National Laboratories was able to make the end product more usable and shorten the prototyping and editing phases. A critical issue was simultaneous development of paper and on-line versions of the textbook. In addition, interface consistency presented difficulties with distinct goals and limitations for each media. Many of these problems were resolved swiftly with human factors input using templates,more » style guides and iterative usability testing of both paper and on-line versions. Writing style continuity was also problematic with numerous authors contributing to the text.« less

Feedback from uncertainties propagation research projects conducted in different hydraulic fields: outcomes for engineering projects and nuclear safety assessment.

NASA Astrophysics Data System (ADS)

Bacchi, Vito; Duluc, Claire-Marie; Bertrand, Nathalie; Bardet, Lise

2017-04-01

In recent years, in the context of hydraulic risk assessment, much effort has been put into the development of sophisticated numerical model systems able reproducing surface flow field. These numerical models are based on a deterministic approach and the results are presented in terms of measurable quantities (water depths, flow velocities, etc…). However, the modelling of surface flows involves numerous uncertainties associated both to the numerical structure of the model, to the knowledge of the physical parameters which force the system and to the randomness inherent to natural phenomena. As a consequence, dealing with uncertainties can be a difficult task for both modelers and decision-makers [Ioss, 2011]. In the context of nuclear safety, IRSN assesses studies conducted by operators for different reference flood situations (local rain, small or large watershed flooding, sea levels, etc…), that are defined in the guide ASN N°13 [ASN, 2013]. The guide provides some recommendations to deal with uncertainties, by proposing a specific conservative approach to cover hydraulic modelling uncertainties. Depending of the situation, the influencing parameter might be the Strickler coefficient, levee behavior, simplified topographic assumptions, etc. Obviously, identifying the most influencing parameter and giving it a penalizing value is challenging and usually questionable. In this context, IRSN conducted cooperative (Compagnie Nationale du Rhone, I-CiTy laboratory of Polytech'Nice, Atomic Energy Commission, Bureau de Recherches Géologiques et Minières) research activities since 2011 in order to investigate feasibility and benefits of Uncertainties Analysis (UA) and Global Sensitivity Analysis (GSA) when applied to hydraulic modelling. A specific methodology was tested by using the computational environment Promethee, developed by IRSN, which allows carrying out uncertainties propagation study. This methodology was applied with various numerical models and in different contexts, as river flooding on the Rhône River (Nguyen et al., 2015) and on the Garonne River, for the studying of local rainfall (Abily et al., 2016) or for tsunami generation, in the framework of the ANR-research project TANDEM. The feedback issued from these previous studies is analyzed (technical problems, limitations, interesting results, etc…) and the perspectives and a discussion on how a probabilistic approach of uncertainties should improve the actual deterministic methodology for risk assessment (also for other engineering applications) will be finally given.

Interoperable Acquisition for Systems of Systems: The Challenges

DTIC Science & Technology

2006-09-01

Interoperable Acquisition for Systems of Systems: The Challenges James D. Smith II D. Mike Phillips September 2006 TECHNICAL NOTE...Failure of Program-Centric Risk Management 10 3.3.2 Absence of System-of-Systems Engineering 12 3.3.3 Disconnect Between System-of-Systems...SOFTWARE ENGINEERING INSTITUTE | vii viii | CMU/SEI-2006-TN-034 Abstract Large, complex systems development has always been challenging , even when the

Configuration Management File Manager Developed for Numerical Propulsion System Simulation

NASA Technical Reports Server (NTRS)

Follen, Gregory J.

1997-01-01

One of the objectives of the High Performance Computing and Communication Project's (HPCCP) Numerical Propulsion System Simulation (NPSS) is to provide a common and consistent way to manage applications, data, and engine simulations. The NPSS Configuration Management (CM) File Manager integrated with the Common Desktop Environment (CDE) window management system provides a common look and feel for the configuration management of data, applications, and engine simulations for U.S. engine companies. In addition, CM File Manager provides tools to manage a simulation. Features include managing input files, output files, textual notes, and any other material normally associated with simulation. The CM File Manager includes a generic configuration management Application Program Interface (API) that can be adapted for the configuration management repositories of any U.S. engine company.

Public health engineering education in India: current scenario, opportunities and challenges.

PubMed

Hussain, Mohammad Akhtar; Sharma, Kavya; Zodpey, Sanjay

2011-01-01

Public health engineering can play an important and significant role in solving environmental health issues. In order to confront public health challenges emerging out of environmental problems we need adequately trained public health engineers / environmental engineers. Considering the current burden of disease attributable to environmental factors and expansion in scope of applications of public health / environmental engineering science, it is essential to understand the present scenario of teaching, training and capacity building programs in these areas. Against this background the present research was carried out to know the current teaching and training programs in public health engineering and related disciplines in India and to understand the potential opportunities and challenges available. A systematic, predefined approach was used to collect and assemble the data related to various teaching and training programs in public health engineering / environmental engineering in India. Public health engineering / environmental engineering education and training in the country is mainly offered through engineering institutions, as pre-service and in-service training. Pre-service programs include diploma, degree (graduate) and post-graduate courses affiliated to various state technical boards, institutes and universities, whereas in-service training is mainly provided by Government of India recognized engineering and public health training institutes. Though trainees of these programs acquire skills related to engineering sciences, they significantly lack in public health skills. The teaching and training of public health engineering / environmental engineering is limited as a part of public health programs (MD Community Medicine, MPH, DPH) in India. There is need for developing teaching and training of public health engineering or environmental engineering as an interdisciplinary subject. Public health institutes can play an important and significant role in this regard by engaging themselves in initiating specialized programs in this domain.

A One Dimensional, Time Dependent Inlet/Engine Numerical Simulation for Aircraft Propulsion Systems

NASA Technical Reports Server (NTRS)

Garrard, Doug; Davis, Milt, Jr.; Cole, Gary

1999-01-01

The NASA Lewis Research Center (LeRC) and the Arnold Engineering Development Center (AEDC) have developed a closely coupled computer simulation system that provides a one dimensional, high frequency inlet/engine numerical simulation for aircraft propulsion systems. The simulation system, operating under the LeRC-developed Application Portable Parallel Library (APPL), closely coupled a supersonic inlet with a gas turbine engine. The supersonic inlet was modeled using the Large Perturbation Inlet (LAPIN) computer code, and the gas turbine engine was modeled using the Aerodynamic Turbine Engine Code (ATEC). Both LAPIN and ATEC provide a one dimensional, compressible, time dependent flow solution by solving the one dimensional Euler equations for the conservation of mass, momentum, and energy. Source terms are used to model features such as bleed flows, turbomachinery component characteristics, and inlet subsonic spillage while unstarted. High frequency events, such as compressor surge and inlet unstart, can be simulated with a high degree of fidelity. The simulation system was exercised using a supersonic inlet with sixty percent of the supersonic area contraction occurring internally, and a GE J85-13 turbojet engine.

Rotary-Wing Relevant Compressor Aero Research and Technology Development Activities at Glenn Research Center

NASA Technical Reports Server (NTRS)

Welch, Gerard E.; Hathaway, Michael D.; Skoch, Gary J.; Snyder, Christopher A.

2012-01-01

Technical challenges of compressors for future rotorcraft engines are driven by engine-level and component-level requirements. Cycle analyses are used to highlight the engine-level challenges for 3000, 7500, and 12000 SHP-class engines, which include retention of performance and stability margin at low corrected flows, and matching compressor type, axial-flow or centrifugal, to the low corrected flows and high temperatures in the aft stages. At the component level: power-to-weight and efficiency requirements impel designs with lower inherent aerodynamic stability margin; and, optimum engine overall pressure ratios lead to small blade heights and the associated challenges of scale, particularly increased clearance-to-span ratios. The technical challenges associated with the aerodynamics of low corrected flows and stability management impel the compressor aero research and development efforts reviewed herein. These activities include development of simple models for clearance sensitivities to improve cycle calculations, full-annulus, unsteady Navier-Stokes simulations used to elucidate stall, its inception, and the physics of stall control by discrete tip-injection, development of an actuator-duct-based model for rapid simulation of nonaxisymmetric flow fields (e.g., due inlet circumferential distortion), advanced centrifugal compressor stage development and experimentation, and application of stall control in a T700 engine.

40 CFR 1054.230 - How do I select emission families?

Code of Federal Regulations, 2012 CFR

2012-07-01

... control for engine operation, other than governing (mechanical or electronic). (9) The numerical level of... POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, SMALL NONROAD SPARK-IGNITION ENGINES AND EQUIPMENT..., divide your product line into families of engines that are expected to have similar emission...

40 CFR 1054.230 - How do I select emission families?

Code of Federal Regulations, 2011 CFR

2011-07-01

... control for engine operation, other than governing (mechanical or electronic). (9) The numerical level of... POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, SMALL NONROAD SPARK-IGNITION ENGINES AND EQUIPMENT..., divide your product line into families of engines that are expected to have similar emission...

40 CFR 1054.230 - How do I select emission families?

Code of Federal Regulations, 2013 CFR

2013-07-01

... control for engine operation, other than governing (mechanical or electronic). (9) The numerical level of... POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, SMALL NONROAD SPARK-IGNITION ENGINES AND EQUIPMENT..., divide your product line into families of engines that are expected to have similar emission...

40 CFR 1054.230 - How do I select emission families?

Code of Federal Regulations, 2014 CFR

2014-07-01

... control for engine operation, other than governing (mechanical or electronic). (9) The numerical level of... POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, SMALL NONROAD SPARK-IGNITION ENGINES AND EQUIPMENT..., divide your product line into families of engines that are expected to have similar emission...

Effect of Accessory Power Take-off Variation on a Turbofan Engine Performance

DTIC Science & Technology

2012-09-26

amount of energy from the low pressure spool shaft. A high bypass turbofan engine was modeled using the Numerical Propulsion System Simulation ( NPSS ...4 II.2 Power Extraction Techniques ..........................................................................8 II.3 NPSS ...Methodology and Simulation Setup ...........................................................................25 III.1 Engine NPSS Model

Optimization strategy for and structural properties of traffic efficiency under bounded information accessibility

NASA Astrophysics Data System (ADS)

Sanghyun, Ahn; Seungwoong, Ha; Kim, Soo Yong

2016-06-01

A vital challenge for many socioeconomic systems is determining the optimum use of limited information. Traffic systems, wherein the range of resources is limited, are a particularly good example of this challenge. Based on bounded information accessibility in terms of, for example, high costs or technical limitations, we develop a new optimization strategy to improve the efficiency of a traffic system with signals and intersections. Numerous studies, including the study by Chowdery and Schadschneider (whose method we denote by ChSch), have attempted to achieve the maximum vehicle speed or the minimum wait time for a given traffic condition. In this paper, we introduce a modified version of ChSch with an independently functioning, decentralized control system. With the new model, we determine the optimization strategy under bounded information accessibility, which proves the existence of an optimal point for phase transitions in the system. The paper also provides insight that can be applied by traffic engineers to create more efficient traffic systems by analyzing the area and symmetry of local sites. We support our results with a statistical analysis using empirical traffic data from Seoul, Korea.

Advanced technology payoffs for future rotorcraft, commuter aircraft, cruise missile, and APU propulsion systems

NASA Technical Reports Server (NTRS)

Turk, M. A.; Zeiner, P. K.

1986-01-01

In connection with the significant advances made regarding the performance of larger gas turbines, challenges arise concerning the improvement of small gas turbine engines in the 250 to 1000 horsepower range. In response to these challenges, the NASA/Army-sponsored Small Engine Component Technology (SECT) study was undertaken with the objective to identify the engine cycle, configuration, and component technology requirements for the substantial performance improvements desired in year-2000 small gas turbine engines. In the context of this objective, an American turbine engine company evaluated engines for four year-2000 applications, including a rotorcraft, a commuter aircraft, a supersonic cruise missile, and an auxiliary power unit (APU). Attention is given to reference missions, reference engines, reference aircraft, year-2000 technology projections, cycle studies, advanced engine selections, and a technology evaluation.

Structural Engineering Managers - Innovation Challenges for their Skills

NASA Astrophysics Data System (ADS)

Linkeschová, D.; Tichá, A.

2015-11-01

The profession of a structural engineer is highly responsible, because the consequences of a structural engineer's errors result not only in economic damage to the property and often irreversible damage to the environment, they can also lead to direct loss of lives. In the current turbulent, dynamically developing society the managerial methods of structural engineers should not stagnate at the level of the last century applications. This paper deals with the challenges which the ongoing century poses to structural engineers and managers. It compares the results of research regarding the current state of managerial skills of structural engineers in Czech building companies to the defined skills of the 21st century's managers according to the global research programme ITL Research and according to the Vision for the Future of Structural Engineering, drawn up by Structural Engineering Institute - SEI ASCE.

Tissue engineering: state of the art in oral rehabilitation

PubMed Central

SCHELLER, E. L.; KREBSBACH, P. H.; KOHN, D. H.

2009-01-01

SUMMARY More than 85% of the global population requires repair or replacement of a craniofacial structure. These defects range from simple tooth decay to radical oncologic craniofacial resection. Regeneration of oral and craniofacial tissues presents a formidable challenge that requires synthesis of basic science, clinical science and engineering technology. Identification of appropriate scaffolds, cell sources and spatial and temporal signals (the tissue engineering triad) is necessary to optimize development of a single tissue, hybrid organ or interface. Furthermore, combining the understanding of the interactions between molecules of the extracellular matrix and attached cells with an understanding of the gene expression needed to induce differentiation and tissue growth will provide the design basis for translating basic science into rationally developed components of this tissue engineering triad. Dental tissue engineers are interested in regeneration of teeth, oral mucosa, salivary glands, bone and periodontium. Many of these oral structures are hybrid tissues. For example, engineering the periodontium requires growth of alveolar bone, cementum and the periodontal ligament. Recapitulation of biological development of hybrid tissues and interfaces presents a challenge that exceeds that of engineering just a single tissue. Advances made in dental interface engineering will allow these tissues to serve as model systems for engineering other tissues or organs of the body. This review will begin by covering basic tissue engineering principles and strategic design of functional biomaterials. We will then explore the impact of biomaterials design on the status of craniofacial tissue engineering and current challenges and opportunities in dental tissue engineering. PMID:19228277

Tissue engineering: state of the art in oral rehabilitation.

PubMed

Scheller, E L; Krebsbach, P H; Kohn, D H

2009-05-01

More than 85% of the global population requires repair or replacement of a craniofacial structure. These defects range from simple tooth decay to radical oncologic craniofacial resection. Regeneration of oral and craniofacial tissues presents a formidable challenge that requires synthesis of basic science, clinical science and engineering technology. Identification of appropriate scaffolds, cell sources and spatial and temporal signals (the tissue engineering triad) is necessary to optimize development of a single tissue, hybrid organ or interface. Furthermore, combining the understanding of the interactions between molecules of the extracellular matrix and attached cells with an understanding of the gene expression needed to induce differentiation and tissue growth will provide the design basis for translating basic science into rationally developed components of this tissue engineering triad. Dental tissue engineers are interested in regeneration of teeth, oral mucosa, salivary glands, bone and periodontium. Many of these oral structures are hybrid tissues. For example, engineering the periodontium requires growth of alveolar bone, cementum and the periodontal ligament. Recapitulation of biological development of hybrid tissues and interfaces presents a challenge that exceeds that of engineering just a single tissue. Advances made in dental interface engineering will allow these tissues to serve as model systems for engineering other tissues or organs of the body. This review will begin by covering basic tissue engineering principles and strategic design of functional biomaterials. We will then explore the impact of biomaterials design on the status of craniofacial tissue engineering and current challenges and opportunities in dental tissue engineering.

Workforce Challenges and Retention Success Stories

NASA Technical Reports Server (NTRS)

Donohue, John T.

2008-01-01

This viewgraph document discusses the current and future challenges in building and retaining the required workforce of scientist and engineers for NASA. Specifically, the talk reviews the current situation at the Goddard Space Flight Center in Greenbelt, Maryland. Several programs at NASA for high school and college students to assist in inspiring the next generation of scientist and engineers are reviewed. The issue of retention of the best of the young scientists and engineers is also reviewed, with a brief review of several young engineers and their success with and for NASA.

Challenges and Opportunities: Building a Relationship Between a Department of Biomedical Engineering and a Medical School.

PubMed

George, Steven C; Meyerand, M Elizabeth

2017-03-01

A department of biomedical engineering can significantly enhance the impact of their research and training programs if a productive relationship with a medical school can be established. In order to develop such a relationship, significant hurdles must be overcome. This editorial summarizes some of the major challenges and opportunities for a department of biomedical engineering as they seek to build or enhance a relationship with a medical school. The ideas were formulated by engaging the collective wisdom from the Council of Chairs of the biomedical engineering departments.

Regenerative therapy and tissue engineering for the treatment of end-stage cardiac failure: new developments and challenges.

PubMed

Finosh, G T; Jayabalan, Muthu

2012-01-01

Regeneration of myocardium through regenerative therapy and tissue engineering is appearing as a prospective treatment modality for patients with end-stage heart failure. Focusing on this area, this review highlights the new developments and challenges in the regeneration of myocardial tissue. The role of various cell sources, calcium ion and cytokine on the functional performance of regenerative therapy is discussed. The evolution of tissue engineering and the role of tissue matrix/scaffold, cell adhesion and vascularisation on tissue engineering of cardiac tissue implant are also discussed.

Status, Vision, and Challenges of an Intelligent Distributed Engine Control Architecture

NASA Technical Reports Server (NTRS)

Behbahani, Alireza; Culley, Dennis; Garg, Sanjay; Millar, Richard; Smith, Bert; Wood, Jim; Mahoney, Tim; Quinn, Ronald; Carpenter, Sheldon; Mailander, Bill;

Gravitational Wave Science: Challenges for Numerical Relativistic Astrophysics

NASA Technical Reports Server (NTRS)

Cenrella, Joan

2005-01-01

Gravitational wave detectors on earth and in space will open up a new observational window on the universe. The new information about astrophysics and fundamental physics these observations will bring is expected to pose exciting challenges. This talk will provide an overview of this emerging area of gravitational wave science, with a focus on the challenges it will bring for numerical relativistic astrophysics and a look at some recent results.

Engineering Education in K-12 Schools

NASA Astrophysics Data System (ADS)

Spence, Anne

2013-03-01

Engineers rely on physicists as well as other scientists and mathematicians to explain the world in which we live. Engineers take this knowledge of the world and use it to create the world that never was. The teaching of physics and other sciences as well as mathematics is critical to maintaining our national workforce. Science and mathematics education are inherently different, however, from engineering education. Engineering educators seek to enable students to develop the habits of mind critical for innovation. Through understanding of the engineering design process and how it differs from the scientific method, students can apply problem and project based learning to solve the challenges facing society today. In this talk, I will discuss the elements critical to a solid K-12 engineering education that integrates science and mathematics to solve challenges throughout the world.

Experimental and numerical results for a generic axisymmetric single-engine afterbody with tails at transonic speeds

NASA Technical Reports Server (NTRS)

Burley, J. R., II; Carlson, J. R.; Henderson, W. P.

1986-01-01

Static pressure measurements were made on the afterbody, nozzle and tails of a generic single-engine axisymmetric fighter configuration. Data were recorded at Mach numbers of 0.6, 0.9, and 1.2. NPR was varied from 1.0 to 8.0 and angle of attack was varied from -3 deg. to 9 deg. Experimental data were compared with numerical results from two state-of-the-art computer codes.

Biotechnology; Managing the Risks of Field Testing Genetically Engineered Organisms

DTIC Science & Technology

1988-06-01

jurisdictional lines. The agencies’ principal regulatory tool for managing the risks of field testing genetically engineered organisms is the authority to...Regulatory authority has been established in numerous federal statutes designed to prevent the occurrence of harm to the environment and public health...would not be reviewed or regulated at all. According to the Insti- tute, "there are numerous organisms outside the confines of t he plant ST~( Iflt l l l

Coupling artificial intelligence and numerical computation for engineering design (Invited paper)

NASA Astrophysics Data System (ADS)

Tong, S. S.

1986-01-01

The possibility of combining artificial intelligence (AI) systems and numerical computation methods for engineering designs is considered. Attention is given to three possible areas of application involving fan design, controlled vortex design of turbine stage blade angles, and preliminary design of turbine cascade profiles. Among the AI techniques discussed are: knowledge-based systems; intelligent search; and pattern recognition systems. The potential cost and performance advantages of an AI-based design-generation system are discussed in detail.

Summary of research in applied mathematics, numerical analysis, and computer sciences

NASA Technical Reports Server (NTRS)

1986-01-01

The major categories of current ICASE research programs addressed include: numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; control and parameter identification problems, with emphasis on effective numerical methods; computational problems in engineering and physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and computer systems and software, especially vector and parallel computers.

Grand challenge commentary: Transforming biosynthesis into an information science.

PubMed

Bayer, Travis S

2010-12-01

Engineering biosynthetic pathways to natural products is a challenging endeavor that promises to provide new therapeutics and tools to manipulate biology. Information-guided design strategies and tools could unlock the creativity of a wide spectrum of scientists and engineers by decoupling expertise from implementation.

Problem Decomposition and Recomposition in Engineering Design: A Comparison of Design Behavior between Professional Engineers, Engineering Seniors, and Engineering Freshmen

ERIC Educational Resources Information Center

Song, Ting; Becker, Kurt; Gero, John; DeBerard, Scott; DeBerard, Oenardi; Reeve, Edward

2016-01-01

The authors investigated the differences in using problem decomposition and problem recomposition between dyads of engineering experts, engineering seniors, and engineering freshmen. Participants worked in dyads to complete an engineering design challenge within 1 hour. The entire design process was video and audio recorded. After the design…

Challenges to Laser-Based Imaging Techniques in Gas Turbine Combustor Systems for Aerospace Applications

NASA Technical Reports Server (NTRS)

Locke, Randy J.; Anderson, Robert C.; Zaller, Michelle M.; Hicks, Yolanda R.

1998-01-01

Increasingly severe constraints on emissions, noise and fuel efficiency must be met by the next generation of commercial aircraft powerplants. At NASA Lewis Research Center (LeRC) a cooperative research effort with industry is underway to design and test combustors that will meet these requirements. To accomplish these tasks, it is necessary to gain both a detailed understanding of the combustion processes and a precise knowledge of combustor and combustor sub-component performance at close to actual conditions. To that end, researchers at LeRC are engaged in a comprehensive diagnostic investigation of high pressure reacting flowfields that duplicate conditions expected within the actual engine combustors. Unique, optically accessible flame-tubes and sector rig combustors, designed especially for these tests. afford the opportunity to probe these flowfields with the most advanced, laser-based optical diagnostic techniques. However, these same techniques, tested and proven on comparatively simple bench-top gaseous flame burners, encounter numerous restrictions and challenges when applied in these facilities. These include high pressures and temperatures, large flow rates, liquid fuels, remote testing, and carbon or other material deposits on combustor windows. Results are shown that document the success and versatility of these nonintrusive optical diagnostics despite the challenges to their implementation in realistic systems.

Fully implicit adaptive mesh refinement algorithm for reduced MHD

NASA Astrophysics Data System (ADS)

Philip, Bobby; Pernice, Michael; Chacon, Luis

2006-10-01

In the macroscopic simulation of plasmas, the numerical modeler is faced with the challenge of dealing with multiple time and length scales. Traditional approaches based on explicit time integration techniques and fixed meshes are not suitable for this challenge, as such approaches prevent the modeler from using realistic plasma parameters to keep the computation feasible. We propose here a novel approach, based on implicit methods and structured adaptive mesh refinement (SAMR). Our emphasis is on both accuracy and scalability with the number of degrees of freedom. As a proof-of-principle, we focus on the reduced resistive MHD model as a basic MHD model paradigm, which is truly multiscale. The approach taken here is to adapt mature physics-based technology to AMR grids, and employ AMR-aware multilevel techniques (such as fast adaptive composite grid --FAC-- algorithms) for scalability. We demonstrate that the concept is indeed feasible, featuring near-optimal scalability under grid refinement. Results of fully-implicit, dynamically-adaptive AMR simulations in challenging dissipation regimes will be presented on a variety of problems that benefit from this capability, including tearing modes, the island coalescence instability, and the tilt mode instability. L. Chac'on et al., J. Comput. Phys. 178 (1), 15- 36 (2002) B. Philip, M. Pernice, and L. Chac'on, Lecture Notes in Computational Science and Engineering, accepted (2006)

Testing Scientific Software: A Systematic Literature Review

PubMed Central

Kanewala, Upulee; Bieman, James M.

2014-01-01

Context Scientific software plays an important role in critical decision making, for example making weather predictions based on climate models, and computation of evidence for research publications. Recently, scientists have had to retract publications due to errors caused by software faults. Systematic testing can identify such faults in code. Objective This study aims to identify specific challenges, proposed solutions, and unsolved problems faced when testing scientific software. Method We conducted a systematic literature survey to identify and analyze relevant literature. We identified 62 studies that provided relevant information about testing scientific software. Results We found that challenges faced when testing scientific software fall into two main categories: (1) testing challenges that occur due to characteristics of scientific software such as oracle problems and (2) testing challenges that occur due to cultural differences between scientists and the software engineering community such as viewing the code and the model that it implements as inseparable entities. In addition, we identified methods to potentially overcome these challenges and their limitations. Finally we describe unsolved challenges and how software engineering researchers and practitioners can help to overcome them. Conclusions Scientific software presents special challenges for testing. Specifically, cultural differences between scientist developers and software engineers, along with the characteristics of the scientific software make testing more difficult. Existing techniques such as code clone detection can help to improve the testing process. Software engineers should consider special challenges posed by scientific software such as oracle problems when developing testing techniques. PMID:25125798

Investigation of metallurgical coatings for automotive applications

NASA Astrophysics Data System (ADS)

Su, Jun Feng

Metallurgical coatings have been widely used in the automotive industry from component machining, engine daily running to body decoration due to their high hardness, wear resistance, corrosion resistance and low friction coefficient. With high demands in energy saving, weight reduction and limiting environmental impact, the use of new materials such as light Aluminum/magnesium alloys with high strength-weight ratio for engine block and advanced high-strength steel (AHSS) with better performance in crash energy management for die stamping, are increasing. However, challenges are emerging when these new materials are applied such as the wear of the relative soft light alloys and machining tools for hard AHSS. The protective metallurgical coatings are the best option to profit from these new materials' advantages without altering largely in mass production equipments, machinery, tools and human labor. In this dissertation, a plasma electrolytic oxidation (PEO) coating processing on aluminum alloys was introduced in engine cylinder bores to resist wear and corrosion. The tribological behavior of the PEO coatings under boundary and starve lubrication conditions was studied experimentally and numerically for the first time. Experimental results of the PEO coating demonstrated prominent wear resistance and low friction, taking into account the extreme working conditions. The numerical elastohydrodynamic lubrication (EHL) and asperity contact based tribological study also showed a promising approach on designing low friction and high wear resistant PEO coatings. Other than the fabrication of the new coatings, a novel coating evaluation methodology, namely, inclined impact sliding tester was presented in the second part of this dissertation. This methodology has been developed and applied in testing and analyzing physical vapor deposition (PVD)/ chemical vapor deposition (CVD)/PEO coatings. Failure mechanisms of these common metallurgical hard coatings were systematically studied and summarized via the new testing methodology. Field tests based on the new coating characterization technique proved that this methodology is reliable, effective and economical.

Integrating numerical computation into the undergraduate education physics curriculum using spreadsheet excel

NASA Astrophysics Data System (ADS)

Fauzi, Ahmad

2017-11-01

Numerical computation has many pedagogical advantages: it develops analytical skills and problem-solving skills, helps to learn through visualization, and enhances physics education. Unfortunately, numerical computation is not taught to undergraduate education physics students in Indonesia. Incorporate numerical computation into the undergraduate education physics curriculum presents many challenges. The main challenges are the dense curriculum that makes difficult to put new numerical computation course and most students have no programming experience. In this research, we used case study to review how to integrate numerical computation into undergraduate education physics curriculum. The participants of this research were 54 students of the fourth semester of physics education department. As a result, we concluded that numerical computation could be integrated into undergraduate education physics curriculum using spreadsheet excel combined with another course. The results of this research become complements of the study on how to integrate numerical computation in learning physics using spreadsheet excel.

A Case Study of a College-Wide First-Year Undergraduate Engineering Course

ERIC Educational Resources Information Center

Aloul, Fadi; Zualkernan, Imran; Husseini, Ghaleb; El-Hag, Ayman; Al-Assaf, Yousef

2015-01-01

Introductory engineering courses are either programme specific or expose students to engineering as a broad discipline by including materials from various engineering programmes. A common introductory engineering course that spans different engineering programmes raises challenges, including the high cost of resources as well as the lack of…

Anxiety among Engineering Students in a Graduate EFL Classroom

ERIC Educational Resources Information Center

Samoilova, Valeriia; Thanh, Vo Duy; Wilang, Jeffrey Dawala

2017-01-01

This article reports the descriptive results of foreign language anxiety experiences of engineering students in a top-ranked research university in Thailand. Although numerous studies have been conducted in the past years about English language anxiety, few studies have reported anxiety situations specific to Thai engineering graduate students in…

Multifunctional Collaborative Modeling and Analysis Methods in Engineering Science

NASA Technical Reports Server (NTRS)

Ransom, Jonathan B.; Broduer, Steve (Technical Monitor)

2001-01-01

Engineers are challenged to produce better designs in less time and for less cost. Hence, to investigate novel and revolutionary design concepts, accurate, high-fidelity results must be assimilated rapidly into the design, analysis, and simulation process. This assimilation should consider diverse mathematical modeling and multi-discipline interactions necessitated by concepts exploiting advanced materials and structures. Integrated high-fidelity methods with diverse engineering applications provide the enabling technologies to assimilate these high-fidelity, multi-disciplinary results rapidly at an early stage in the design. These integrated methods must be multifunctional, collaborative, and applicable to the general field of engineering science and mechanics. Multifunctional methodologies and analysis procedures are formulated for interfacing diverse subdomain idealizations including multi-fidelity modeling methods and multi-discipline analysis methods. These methods, based on the method of weighted residuals, ensure accurate compatibility of primary and secondary variables across the subdomain interfaces. Methods are developed using diverse mathematical modeling (i.e., finite difference and finite element methods) and multi-fidelity modeling among the subdomains. Several benchmark scalar-field and vector-field problems in engineering science are presented with extensions to multidisciplinary problems. Results for all problems presented are in overall good agreement with the exact analytical solution or the reference numerical solution. Based on the results, the integrated modeling approach using the finite element method for multi-fidelity discretization among the subdomains is identified as most robust. The multiple-method approach is advantageous when interfacing diverse disciplines in which each of the method's strengths are utilized. The multifunctional methodology presented provides an effective mechanism by which domains with diverse idealizations are interfaced. This capability rapidly provides the high-fidelity results needed in the early design phase. Moreover, the capability is applicable to the general field of engineering science and mechanics. Hence, it provides a collaborative capability that accounts for interactions among engineering analysis methods.

Systems engineering for very large systems

NASA Technical Reports Server (NTRS)

Lewkowicz, Paul E.

1993-01-01

Very large integrated systems have always posed special problems for engineers. Whether they are power generation systems, computer networks or space vehicles, whenever there are multiple interfaces, complex technologies or just demanding customers, the challenges are unique. 'Systems engineering' has evolved as a discipline in order to meet these challenges by providing a structured, top-down design and development methodology for the engineer. This paper attempts to define the general class of problems requiring the complete systems engineering treatment and to show how systems engineering can be utilized to improve customer satisfaction and profit ability. Specifically, this work will focus on a design methodology for the largest of systems, not necessarily in terms of physical size, but in terms of complexity and interconnectivity.

Systems engineering for very large systems

NASA Astrophysics Data System (ADS)

Lewkowicz, Paul E.

Very large integrated systems have always posed special problems for engineers. Whether they are power generation systems, computer networks or space vehicles, whenever there are multiple interfaces, complex technologies or just demanding customers, the challenges are unique. 'Systems engineering' has evolved as a discipline in order to meet these challenges by providing a structured, top-down design and development methodology for the engineer. This paper attempts to define the general class of problems requiring the complete systems engineering treatment and to show how systems engineering can be utilized to improve customer satisfaction and profit ability. Specifically, this work will focus on a design methodology for the largest of systems, not necessarily in terms of physical size, but in terms of complexity and interconnectivity.

Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes

PubMed Central

2011-01-01

Background Development of a standardized platform for the rapid expansion of tumor-infiltrating lymphocytes (TILs) with anti-tumor function from patients with limited TIL numbers or tumor tissues challenges their clinical application. Methods To facilitate adoptive immunotherapy, we applied genetically-engineered K562 cell-based artificial antigen presenting cells (aAPCs) for the direct and rapid expansion of TILs isolated from primary cancer specimens. Results TILs outgrown in IL-2 undergo rapid, CD28-independent expansion in response to aAPC stimulation that requires provision of exogenous IL-2 cytokine support. aAPCs induce numerical expansion of TILs that is statistically similar to an established rapid expansion method at a 100-fold lower feeder cell to TIL ratio, and greater than those achievable using anti-CD3/CD28 activation beads or extended IL-2 culture. aAPC-expanded TILs undergo numerical expansion of tumor antigen-specific cells, remain amenable to secondary aAPC-based expansion, and have low CD4/CD8 ratios and FOXP3+ CD4+ cell frequencies. TILs can also be expanded directly from fresh enzyme-digested tumor specimens when pulsed with aAPCs. These "young" TILs are tumor-reactive, positively skewed in CD8+ lymphocyte composition, CD28 and CD27 expression, and contain fewer FOXP3+ T cells compared to parallel IL-2 cultures. Conclusion Genetically-enhanced aAPCs represent a standardized, "off-the-shelf" platform for the direct ex vivo expansion of TILs of suitable number, phenotype and function for use in adoptive immunotherapy. PMID:21827675

Finite element models of the human shoulder complex: a review of their clinical implications and modelling techniques.

PubMed

Zheng, Manxu; Zou, Zhenmin; Bartolo, Paulo Jorge Da Silva; Peach, Chris; Ren, Lei

2017-02-01

The human shoulder is a complicated musculoskeletal structure and is a perfect compromise between mobility and stability. The objective of this paper is to provide a thorough review of previous finite element (FE) studies in biomechanics of the human shoulder complex. Those FE studies to investigate shoulder biomechanics have been reviewed according to the physiological and clinical problems addressed: glenohumeral joint stability, rotator cuff tears, joint capsular and labral defects and shoulder arthroplasty. The major findings, limitations, potential clinical applications and modelling techniques of those FE studies are critically discussed. The main challenges faced in order to accurately represent the realistic physiological functions of the shoulder mechanism in FE simulations involve (1) subject-specific representation of the anisotropic nonhomogeneous material properties of the shoulder tissues in both healthy and pathological conditions; (2) definition of boundary and loading conditions based on individualised physiological data; (3) more comprehensive modelling describing the whole shoulder complex including appropriate three-dimensional (3D) representation of all major shoulder hard tissues and soft tissues and their delicate interactions; (4) rigorous in vivo experimental validation of FE simulation results. Fully validated shoulder FE models would greatly enhance our understanding of the aetiology of shoulder disorders, and hence facilitate the development of more efficient clinical diagnoses, non-surgical and surgical treatments, as well as shoulder orthotics and prosthetics. © 2016 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd. © 2016 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.

Assessment of First- and Second-Order Wave-Excitation Load Models for Cylindrical Substructures: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pereyra, Brandon; Wendt, Fabian; Robertson, Amy

2017-03-09

The hydrodynamic loads on an offshore wind turbine's support structure present unique engineering challenges for offshore wind. Two typical approaches used for modeling these hydrodynamic loads are potential flow (PF) and strip theory (ST), the latter via Morison's equation. This study examines the first- and second-order wave-excitation surge forces on a fixed cylinder in regular waves computed by the PF and ST approaches to (1) verify their numerical implementations in HydroDyn and (2) understand when the ST approach breaks down. The numerical implementation of PF and ST in HydroDyn, a hydrodynamic time-domain solver implemented as a module in the FASTmore » wind turbine engineering tool, was verified by showing the consistency in the first- and second-order force output between the two methods across a range of wave frequencies. ST is known to be invalid at high frequencies, and this study investigates where the ST solution diverges from the PF solution. Regular waves across a range of frequencies were run in HydroDyn for a monopile substructure. As expected, the solutions for the first-order (linear) wave-excitation loads resulting from these regular waves are similar for PF and ST when the diameter of the cylinder is small compared to the length of the waves (generally when the diameter-to-wavelength ratio is less than 0.2). The same finding applies to the solutions for second-order wave-excitation loads, but for much smaller diameter-to-wavelength ratios (based on wavelengths of first-order waves).« less

Assessment of First- and Second-Order Wave-Excitation Load Models for Cylindrical Substructures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pereyra, Brandon; Wendt, Fabian; Robertson, Amy

2016-07-01

The hydrodynamic loads on an offshore wind turbine's support structure present unique engineering challenges for offshore wind. Two typical approaches used for modeling these hydrodynamic loads are potential flow (PF) and strip theory (ST), the latter via Morison's equation. This study examines the first- and second-order wave-excitation surge forces on a fixed cylinder in regular waves computed by the PF and ST approaches to (1) verify their numerical implementations in HydroDyn and (2) understand when the ST approach breaks down. The numerical implementation of PF and ST in HydroDyn, a hydrodynamic time-domain solver implemented as a module in the FASTmore » wind turbine engineering tool, was verified by showing the consistency in the first- and second-order force output between the two methods across a range of wave frequencies. ST is known to be invalid at high frequencies, and this study investigates where the ST solution diverges from the PF solution. Regular waves across a range of frequencies were run in HydroDyn for a monopile substructure. As expected, the solutions for the first-order (linear) wave-excitation loads resulting from these regular waves are similar for PF and ST when the diameter of the cylinder is small compared to the length of the waves (generally when the diameter-to-wavelength ratio is less than 0.2). The same finding applies to the solutions for second-order wave-excitation loads, but for much smaller diameter-to-wavelength ratios (based on wavelengths of first-order waves).« less

Some Future Software Engineering Opportunities and Challenges

NASA Astrophysics Data System (ADS)

Boehm, Barry

This paper provides an update and extension of a 2006 paper, “Some Future Trends and Implications for Systems and Software Engineering Processes,” Systems Engineering, Spring 2006. Some of its challenges and opportunities are similar, such as the need to simultaneously achieve high levels of both agility and assurance. Others have emerged as increasingly important, such as the challenges of dealing with ultralarge volumes of data, with multicore chips, and with software as a service. The paper is organized around eight relatively surprise-free trends and two “wild cards” whose trends and implications are harder to foresee. The eight surprise-free trends are:

Steady-State Cycle Deck Launcher Developed for Numerical Propulsion System Simulation

NASA Technical Reports Server (NTRS)

VanDrei, Donald E.

1997-01-01

One of the objectives of NASA's High Performance Computing and Communications Program's (HPCCP) Numerical Propulsion System Simulation (NPSS) is to reduce the time and cost of generating aerothermal numerical representations of engines, called customer decks. These customer decks, which are delivered to airframe companies by various U.S. engine companies, numerically characterize an engine's performance as defined by the particular U.S. airframe manufacturer. Until recently, all numerical models were provided with a Fortran-compatible interface in compliance with the Society of Automotive Engineers (SAE) document AS681F, and data communication was performed via a standard, labeled common structure in compliance with AS681F. Recently, the SAE committee began to develop a new standard: AS681G. AS681G addresses multiple language requirements for customer decks along with alternative data communication techniques. Along with the SAE committee, the NPSS Steady-State Cycle Deck project team developed a standard Application Program Interface (API) supported by a graphical user interface. This work will result in Aerospace Recommended Practice 4868 (ARP4868). The Steady-State Cycle Deck work was validated against the Energy Efficient Engine customer deck, which is publicly available. The Energy Efficient Engine wrapper was used not only to validate ARP4868 but also to demonstrate how to wrap an existing customer deck. The graphical user interface for the Steady-State Cycle Deck facilitates the use of the new standard and makes it easier to design and analyze a customer deck. This software was developed following I. Jacobson's Object-Oriented Design methodology and is implemented in C++. The AS681G standard will establish a common generic interface for U.S. engine companies and airframe manufacturers. This will lead to more accurate cycle models, quicker model generation, and faster validation leading to specifications. The standard will facilitate cooperative work between industry and NASA. The NPSS Steady-State Cycle Deck team released a batch version of the Steady-State Cycle Deck in March 1996. Version 1.1 was released in June 1996. During fiscal 1997, NPSS accepted enhancements and modifications to the Steady-State Cycle Deck launcher. Consistent with NPSS' commercialization plan, these modifications will be done by a third party that can provide long-term software support.

An Object Model for a Rocket Engine Numerical Simulator

NASA Technical Reports Server (NTRS)

Mitra, D.; Bhalla, P. N.; Pratap, V.; Reddy, P.

1998-01-01

Rocket Engine Numerical Simulator (RENS) is a packet of software which numerically simulates the behavior of a rocket engine. Different parameters of the components of an engine is the input to these programs. Depending on these given parameters the programs output the behaviors of those components. These behavioral values are then used to guide the design of or to diagnose a model of a rocket engine "built" by a composition of these programs simulating different components of the engine system. In order to use this software package effectively one needs to have a flexible model of a rocket engine. These programs simulating different components then should be plugged into this modular representation. Our project is to develop an object based model of such an engine system. We are following an iterative and incremental approach in developing the model, as is the standard practice in the area of object oriented design and analysis of softwares. This process involves three stages: object modeling to represent the components and sub-components of a rocket engine, dynamic modeling to capture the temporal and behavioral aspects of the system, and functional modeling to represent the transformational aspects. This article reports on the first phase of our activity under a grant (RENS) from the NASA Lewis Research center. We have utilized Rambaugh's object modeling technique and the tool UML for this purpose. The classes of a rocket engine propulsion system are developed and some of them are presented in this report. The next step, developing a dynamic model for RENS, is also touched upon here. In this paper we will also discuss the advantages of using object-based modeling for developing this type of an integrated simulator over other tools like an expert systems shell or a procedural language, e.g., FORTRAN. Attempts have been made in the past to use such techniques.

Bone Tissue Engineering: Recent Advances and Challenges

PubMed Central

Amini, Ami R.; Laurencin, Cato T.; Nukavarapu, Syam P.

2013-01-01

The worldwide incidence of bone disorders and conditions has trended steeply upward and is expected to double by 2020, especially in populations where aging is coupled with increased obesity and poor physical activity. Engineered bone tissue has been viewed as a potential alternative to the conventional use of bone grafts, due to their limitless supply and no disease transmission. However, bone tissue engineering practices have not proceeded to clinical practice due to several limitations or challenges. Bone tissue engineering aims to induce new functional bone regeneration via the synergistic combination of biomaterials, cells, and factor therapy. In this review, we discuss the fundamentals of bone tissue engineering, highlighting the current state of this field. Further, we review the recent advances of biomaterial and cell-based research, as well as approaches used to enhance bone regeneration. Specifically, we discuss widely investigated biomaterial scaffolds, micro- and nano-structural properties of these scaffolds, and the incorporation of biomimetic properties and/or growth factors. In addition, we examine various cellular approaches, including the use of mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), adult stem cells, induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), and their clinical application strengths and limitations. We conclude by overviewing the challenges that face the bone tissue engineering field, such as the lack of sufficient vascularization at the defect site, and the research aimed at functional bone tissue engineering. These challenges will drive future research in the field. PMID:23339648

Preparing engineers for the challenges of community engagement

NASA Astrophysics Data System (ADS)

Harsh, Matthew; Bernstein, Michael J.; Wetmore, Jameson; Cozzens, Susan; Woodson, Thomas; Castillo, Rafael

2017-11-01

Despite calls to address global challenges through community engagement, engineers are not formally prepared to engage with communities. Little research has been done on means to address this 'engagement gap' in engineering education. We examine the efficacy of an intensive, two-day Community Engagement Workshop for engineers, designed to help engineers better look beyond technology, listen to and learn from people, and empower communities. We assessed the efficacy of the workshop in a non-experimental pre-post design using a questionnaire and a concept map. Questionnaire results indicate participants came away better able to ask questions more broadly inclusive of non-technological dimensions of engineering projects. Concept map results indicate participants have a greater understanding of ways social factors shape complex material systems after completing the programme. Based on the workshop's strengths and weaknesses, we discuss the potential of expanding and supplementing the programme to help engineers account for social aspects central to engineered systems.

Institute for Computer Applications in Science and Engineering (ICASE)

NASA Technical Reports Server (NTRS)

1984-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis and computer science during the period April 1, 1983 through September 30, 1983 is summarized.

Stope Stability Assessment and Effect of Horizontal to Vertical Stress Ratio on the Yielding and Relaxation Zones Around Underground Open Stopes Using Empirical and Finite Element Methods

NASA Astrophysics Data System (ADS)

Sepehri, Mohammadali; Apel, Derek; Liu, Wei

2017-09-01

Predicting the stability of open stopes can be a challenging task for underground mine engineers. For decades, the stability graph method has been used as the first step of open stope design around the world. However, there are some shortcomings with this method. For instance, the stability graph method does not account for the relaxation zones around the stopes. Another limitation of the stability graph is that this method cannot to be used to evaluate the stability of the stopes with high walls made of backfill materials. However, there are several analytical and numerical methods that can be used to overcome these limitations. In this study, both empirical and numerical methods have been used to assess the stability of an open stope located between mine levels N9225 and N9250 at Diavik diamond underground mine. It was shown that the numerical methods can be used as complementary methods along with other analytical and empirical methods to assess the stability of open stopes. A three dimensional elastoplastic finite element model was constructed using Abaqus software. In this paper a sensitivity analysis was performed to investigate the impact of the stress ratio "k" on the extent of the yielding and relaxation zones around the hangingwall and footwall of the understudy stope.

Numerical prediction of turbulent oscillating flow and associated heat transfer

NASA Technical Reports Server (NTRS)

Koehler, W. J.; Patankar, S. V.; Ibele, W. E.

1991-01-01

A crucial point for further development of engines is the optimization of its heat exchangers which operate under oscillatory flow conditions. It has been found that the most important thermodynamic uncertainties in the Stirling engine designs for space power are in the heat transfer between gas and metal in all engine components and in the pressure drop across the heat exchanger components. So far, performance codes cannot predict the power output of a Stirling engine reasonably enough if used for a wide variety of engines. Thus, there is a strong need for better performance codes. However, a performance code is not concerned with the details of the flow. This information must be provided externally. While analytical relationships exist for laminar oscillating flow, there has been hardly any information about transitional and turbulent oscillating flow, which could be introduced into the performance codes. In 1986, a survey by Seume and Simon revealed that most Stirling engine heat exchangers operate in the transitional and turbulent regime. Consequently, research has since focused on the unresolved issue of transitional and turbulent oscillating flow and heat transfer. Since 1988, the University of Minnesota oscillating flow facility has obtained experimental data about transitional and turbulent oscillating flow. However, since the experiments in this field are extremely difficult, lengthy, and expensive, it is advantageous to numerically simulate the flow and heat transfer accurately from first principles. Work done at the University of Minnesota on the development of such a numerical simulation is summarized.

Investigation of the effect of the ejector on the performance of the pulse detonation engine nozzle extension

NASA Astrophysics Data System (ADS)

Korobov, A. E.; Golovastov, S. V.

2015-11-01

Influence of an ejector nozzle extension on gas flow at a pulse detonation engine was investigated numerically and experimentally. Detonation formation was organized in stoichiometric hydrogen-oxygen mixture in cylindrical detonation tube. Cylindrical ejector was constructed and mounted at the open end of the tube. Thrust, air consumption and parameters of the detonation were measured in single and multiple regimes of operation. Axisymmetric model was used in numerical investigation. Equations of Navies-Stokes were solved using a finite-difference scheme Roe of second order of accuracy. Initial conditions were estimated on a base of experimental data. Numerical results were validated with experiments data.

Interdisciplinary and multilevel optimum design. [in aerospace structural engineering

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, Jaroslaw; Haftka, Raphael T.

1987-01-01

Interactions among engineering disciplines and subsystems in engineering system design are surveyed and specific instances of such interactions are described. Examination of the interactions that a traditional design process in which the numerical values of major design variables are decided consecutively is likely to lead to a suboptimal design. Supporting numerical examples are a glider and a space antenna. Under an alternative approach introduced, the design and its sensitivity data from the subsystems and disciplines are generated concurrently and then made available to the system designer enabling him to modify the system design so as to improve its performance. Examples of a framework structure and an airliner wing illustrate that approach.

A numerical study of candidate transverse fuel injector configurations in the Langley scramjet engine

NASA Technical Reports Server (NTRS)

Drummond, J. P.

1980-01-01

A computer program has been developed that numerically solves the two-dimensional Navier-Stokes and species equations near one or more transverse hydrogen fuel injectors in a scramjet engine. The program currently computes the turbulent mixing and reaction of hydrogen fuel and air, and allows the study of separated regions of the flow immediately preceding and following the injectors. The complex shock-expansion structure produced by the injectors in this region of the engine can also be represented. Results are presented that describe the flow field near two opposing transverse fuel injectors and two opposing staged (multiple) injectors, and comparisons between the two configurations are made to assess their mixing and flameholding qualities.

The NASA Marshall engineering thermosphere model

NASA Technical Reports Server (NTRS)

Hickey, Michael Philip

1988-01-01

Described is the NASA Marshall Engineering Thermosphere (MET) Model, which is a modified version of the MFSC/J70 Orbital Atmospheric Density Model as currently used in the J70MM program at MSFC. The modifications to the MFSC/J70 model required for the MET model are described, graphical and numerical examples of the models are included, as is a listing of the MET model computer program. Major differences between the numerical output from the MET model and the MFSC/J70 model are discussed.

Numerical and flight measured interior noise characteristics of a twin-engine turboprop general aviation aircraft

NASA Astrophysics Data System (ADS)

Marulo, F.; Lecce, L.; de Rosa, S.; D'Amato, C. A.; Verde, G.

The paper presents the flight test results of an interior noise measurement campaign on a twin-engine turboprop general aviation aircraft conducted for assessing the real values inside such aircraft and for approaching the problem of its noise reduction. Simultaneously a numerical study has been performed in order to correlate the experimental and the theoretical values, trying to come out with some guidelines for possible improvements without increasing excessively the costs of such study.

Sense codon emancipation for proteome-wide incorporation of noncanonical amino acids: rare isoleucine codon AUA as a target for genetic code expansion

PubMed Central

Bohlke, Nina; Budisa, Nediljko

2014-01-01

One of the major challenges in contemporary synthetic biology is to find a route to engineer synthetic organisms with altered chemical constitution. In terms of core reaction types, nature uses an astonishingly limited repertoire of chemistries when compared with the exceptionally rich and diverse methods of organic chemistry. In this context, the most promising route to change and expand the fundamental chemistry of life is the inclusion of amino acid building blocks beyond the canonical 20 (i.e. expanding the genetic code). This strategy would allow the transfer of numerous chemical functionalities and reactions from the synthetic laboratory into the cellular environment. Due to limitations in terms of both efficiency and practical applicability, state-of-the-art nonsense suppression- or frameshift suppression-based methods are less suitable for such engineering. Consequently, we set out to achieve this goal by sense codon emancipation, that is, liberation from its natural decoding function – a prerequisite for the reassignment of degenerate sense codons to a new 21st amino acid. We have achieved this by redesigning of several features of the post-transcriptional modification machinery which are directly involved in the decoding process. In particular, we report first steps towards the reassignment of 5797 AUA isoleucine codons in Escherichia coli using efficient tools for tRNA nucleotide modification pathway engineering. PMID:24433543

Engineering of Microbial Cell Factories for the Production of Plant Polyphenols with Health-Beneficial Properties.

PubMed

Dudnik, Alexey; Gaspar, Paula; Neves, Ana Rute; Forster, Jochen

2018-05-15

Polyphenols form a group of important natural bioactive compounds with numerous ascribed health-beneficial attributes (e.g. antioxidant, anti-inflammatory, anti-microbial and tumor-suppressing properties). Some polyphenols can also be used as natural dyes or plastic precursors. Notwithstanding their relevance, production of most of these compounds still relies on extraction from plant material, which for most of it is a costly and an inefficient procedure. The use of microbial cell factories for this purpose is an emerging alternative that could allow a more efficient and sustainable production. The most recent advances in molecular biology and genetic engineering, combined with the ever-growing understanding of microbial physiology have led to multiple success stories. Production of multiple polyphenolic compounds or their direct precursors has been achieved not only in the common production hosts, such as Escherichia coli and Saccharomyces cerevisiae but also in Corynebacterium glutamicum and Lactococcus lactis. However, boosting production of native compounds or introduction of heterologous biosynthetic pathways also brings certain challenges, such as the need to express, balance and maintain efficient precursor supply. This review will discuss the most recent advances in the field of metabolic engineering of microorganisms for polyphenol biosynthesis and its future perspectives, as well as outlines their potential health benefits and current production methods. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Control Engineering, System Theory and Mathematics: The Teacher's Challenge

ERIC Educational Resources Information Center

Zenger, K.

2007-01-01

The principles, difficulties and challenges in control education are discussed and compared to the similar problems in the teaching of mathematics and systems science in general. The difficulties of today's students to appreciate the classical teaching of engineering disciplines, which are based on rigorous and scientifically sound grounds, are…

Sustainability: Necessity for a Prosperous Society

ERIC Educational Resources Information Center

Fokkema, Jacob; Jansen, Leo; Mulder, Karel

2005-01-01

Purpose--To present the challenge of sustainable development, the way in which technology can address that challenge and the task of engineering education to train engineers for it. Design/methodology/approach--The paper describes briefly the history of the environmental and sustainability discourse in The Netherlands, as a densely populated…

The European Project Semester at ISEP: The Challenge of Educating Global Engineers

ERIC Educational Resources Information Center

Malheiro, Benedita; Silva, Manuel; Ribeiro, Maria Cristina; Guedes, Pedro; Ferreira, Paulo

2015-01-01

Current engineering education challenges require approaches that promote scientific, technical, design and complementary skills while fostering autonomy, innovation and responsibility. The European Project Semester (EPS) at Instituto Superior de Engenharia do Porto (ISEP) (EPS@ISEP) is a one semester project-based learning programme (30 European…

Geo-Hazards and Mountain Road Development in Nepal: Understanding the Science-Policy-Governance Interface

NASA Astrophysics Data System (ADS)

Dugar, Sumit; Dahal, Vaskar

2015-04-01

The foothills of Nepalese Himalayas located in the neotectonic mountain environment are among some of the most unstable and geomorphologically dynamic landscapes in the world. Young fold mountains in this region are characterized by complex tectonics that influence the occurrence of earthquakes, while climatic processes such as intense orographic rainfall often dictate the occurrence of floods and landslides. Development of linear infrastructures, such as roads, in mountainous terrain characterized by high relief and orogeny is considerably challenging where the complexity of landscape in steep and irregular topography, difficult ground conditions and weak geology, presents engineers and planners with numerous difficulties to construct and maintain mountain roads. Whilst application of engineering geology, geomorphic interpretation of terrain in terms of physiography and hydrology, and identification of geo-hazards along the road corridor is critical for long term operation of mountain roads, low-cost arterial roads in the Himalayan foothills generally fail to incorporate standard road slope engineering structures. This research provides unique insights on policy and governance issues in developing mountainous countries such as Nepal, where achieving a sound balance between sustainability and affordability is a major challenge for road construction. Road development in Nepal is a complex issue where socio-economic and political factors influence the budget allocation for road construction in rural hilly areas. Moreover, most mountain roads are constructed without any geological or geo-technical site investigations due to rampant corruption and lack of adequate engineering supervision. Despite having good examples of rural road construction practices such as the Dharan-Dhankuta Road in Eastern Nepal where comprehensive terrain-evaluation methods and geo-technical surveys led to an improved understanding of road construction, learnings from this project have not informed other road development schemes in Nepal. Geomorphological surveys and robust geo-hazard assessments that factor the spatial and temporal dimensions of the seismic, fluvial and sediment hazards along the road corridor are critical for sustainable development of mountain roads. However, scientific and technical research studies seldom inform mountain road development primarily due to lack of co-ordination between the respective government agencies, access to journal papers in developing countries and unwillingness to adopt novel interventions in rural road construction practices. These challenges are further exacerbated by weak governance and lack of proper policy enforcement that often leads to construction of poorly engineered roads, thereby increasing the risk of rural infrastructural damage from geo-hazards. Though there exists a disconnect between the science-policy-governance interface where information on geo-hazards is neglected in mountain road development due to lack of scientific research and government apathy, there is an opportunity to spur dialogue and sensitize these issues via trans-disciplinary approaches on disaster risk management.

Designing Biomimetic Materials from Marine Organisms.

PubMed

Nichols, William T

2015-01-01

Two biomimetic design approaches that apply biological solutions to engineering problems are discussed. In the first case, motivation comes from an engineering problem and the key challenge is to find analogous biological functions and map them into engineering materials. We illustrate with an example of water pollution remediation through appropriate design of a biomimetic sponge. In the second case, a biological function is already known and the challenge is to identify the appropriate engineering problem. We demonstrate the biological approach with marine diatoms that control energy and materials at their surface providing inspiration for a number of engineering applications. In both cases, it is essential to select materials and structures at the nanoscale to control energy and materials flows at interfaces.

Exploration Design Challenge 2014

NASA Image and Video Library

2014-04-25

NASA Administrator, Charles Bolden and Lockheed Martin CEO, Marillyn Hewson announce the winner of the Exploration Design Challenge at the USA Science and Engineering Festival on April 25, 2014. The goal of the Exploration Design Challenge was for students to research and design ways to protect astronauts from space radiation.The USA Science and Engineering Festival is taking place at the Washington Convention Center in Washington, DC on April 26 and 27, 2014. Photo Credit: (NASA/Aubrey Gemignani)

Confined Detonations and Pulse Detonation Engines

DTIC Science & Technology

2003-01-01

chemically reacting flow was described by the 2D Euler equations &q OF(q) +G(q) W (1) 75 CONFINED DETONATIONS AND PULSE DETONATION ENGINES where q = (p...DETONATIONS AND PULSE DETONATION ENGINES 5 CONCLUDING REMARKS Numerical investigations of RR and MR in a supersonic chemically reacting flows have...formalism of hetero- geneous medium mechanics supplemented with an overall chemical reaction was 141 CONFINED DETONATIONS AND PULSE DETONATION ENGINES

Predicting Engineering Student Attrition Risk Using a Probabilistic Neural Network and Comparing Results with a Backpropagation Neural Network and Logistic Regression

ERIC Educational Resources Information Center

Mason, Cindi; Twomey, Janet; Wright, David; Whitman, Lawrence

2018-01-01

As the need for engineers continues to increase, a growing focus has been placed on recruiting students into the field of engineering and retaining the students who select engineering as their field of study. As a result of this concentration on student retention, numerous studies have been conducted to identify, understand, and confirm…

Engineering Leadership Development Programs a Look at What Is Needed and What Is Being Done

ERIC Educational Resources Information Center

Crumpton-Young, Lesia; McCauley-Bush, Pamela; Rabelo, Luis; Meza, Katherine; Ferreras, Ana; Rodriguez, Betzaida; Millan, Angel; Miranda, David; Kelarestani, Misha

2010-01-01

"The Engineer of 2020: Visions of Engineering in the New Century," published by the National Academy of Engineering (NAE), discusses the importance of current and future engineering graduates possessing skills needed to solve business challenges. To ensure that future engineering graduates are adequately prepared, several universities and…

Engineering biological systems using automated biofoundries.

PubMed

Chao, Ran; Mishra, Shekhar; Si, Tong; Zhao, Huimin

2017-07-01

Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges. Copyright © 2017 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

Field Measurements and Numerical Simulations of Temperature and Moisture in Highway Engineering Using a Frequency Domain Reflectometry Sensor.

PubMed

Yao, Yong-Sheng; Zheng, Jian-Long; Chen, Zeng-Shun; Zhang, Jun-Hui; Li, Yong

2016-06-10

This paper presents a systematic pioneering study on the use of agricultural-purpose frequency domain reflectometry (FDR) sensors to monitor temperature and moisture of a subgrade in highway extension and reconstruction engineering. The principle of agricultural-purpose FDR sensors and the process for embedding this kind of sensors for subgrade engineering purposes are introduced. Based on field measured weather data, a numerical analysis model for temperature and moisture content in the subgrade's soil is built. Comparisons of the temperature and moisture data obtained from numerical simulation and FDR-based measurements are conducted. The results show that: (1) the embedding method and process, data acquisition, and remote transmission presented are reasonable; (2) the temperature and moisture changes are coordinated with the atmospheric environment and they are also in close agreement with numerical calculations; (3) the change laws of both are consistent at positions where the subgrade is compacted uniformly. These results suggest that the data measured by the agricultural-purpose FDR sensors are reliable. The findings of this paper enable a new and effective real-time monitoring method for a subgrade's temperature and moisture changes, and thus broaden the application of agricultural-purpose FDR sensors.

Persistence Factors Associated with First-Year Engineering Technology Learners

ERIC Educational Resources Information Center

Christe, Barbara

2015-01-01

Engineering technology learners are understudied group that comprise the "T" of the science, technology, engineering, and mathematics disciplines. Attrition from engineering technology majors is a profound and complex challenge, as substantially less than half of students who begin an engineering technology major persist through the…

Epistemic Practices of Engineering for Education

ERIC Educational Resources Information Center

Cunningham, Christine M.; Kelly, Gregory J.

2017-01-01

Engineering offers new educational opportunities for students, yet also poses challenges about how to conceptualize the disciplinary core ideas, crosscutting concepts, and science and engineering practices of the disciplinary fields of engineering. In this paper, we draw from empirical studies of engineering in professional and school settings to…

Hedberg Research Conference on Fundamental Controls on Flow in Carbonates: Request for Travel Support for Post-Doctoral Fellows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pyrak-Nolte, Laura J.

Carbonate reservoirs pose a scientific and engineering challenge to geophysical prediction and monitoring of fluid flow in the subsurface. Difficulties in interpreting hydrological, reservoir and other exploration data arise because carbonates are composed of a hierarchy of geological structures, constituents and processes that span a wide spectrum of length and time scales. What makes this problem particularly challenging is that length scales associated with physical structure and processes are often not discrete, but overlap, preventing the definition of discrete elements at one scale to become the building blocks of the next scale. This is particularly true for carbonates where complicatedmore » depositional environments, subsequent post-deposition diagenesis and geochemical interactions result in pores that vary in scale from submicron to centimeters to fractures, variation in fabric composition with fossils, minerals and cement, as well as variations in structural features (e.g., oriented inter- and intra layered - interlaced bedding and/or discontinuous rock units). In addition, this complexity is altered by natural and anthropogenic processes such as changes in stress, fluid content, reactive fluid flow, etc. Thus an accurate geophysical assessment of the flow behavior of carbonate reservoirs requires a fundamental understanding of the interplay of textural and structural features subjected to physical processes that affect and occur on various length and time scales. To address this complexity related to carbonates, a Hedberg conference on “Fundamental Controls on Flow in Carbonates” was held July 8 to 13, 2012, to bring together industry and academic scientists to stimulate innovative ideas that can accelerate research advances related to flow prediction and recovery in carbonate reservoirs. Participants included scientist and engineers from multiple disciplines (such as hydrology, structural geology, geochemistry, reservoir engineering, geophysics, geomechanics, numerical modeling, physical experiments, sedimentology, well-testing, statistics, mathematics, visualization, etc.) who encompass experience as well as the latest advances in these multi-faceted fields. One of the goals was to include early career scientists and engineers (post-doctoral fellows, assistant professors, etc.). With this grant 10 early career scientists and engineers were supported to attend the conference. This reports contains a brief overview of the conference and the list of support participants supported by this grant. Full details of the outcomes of the conference are given in the publication found in the Attachment section of this report.« less

Engineering Motion

ERIC Educational Resources Information Center

Tuttle, Nicole; Stanley, Wendy; Bieniek, Tracy

2016-01-01

For many teachers, engineering can be intimidating; teachers receive little training in engineering, particularly those teaching early elementary students. In addition, the necessity of differentiating for students with special needs can make engineering more challenging to teach. This article describes a professional development program…

Sustainable Development and Energy Geotechnology Potential Roles for Geotechnical Engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

FragaszyProgram Dire, Dr. R. J.; Santamarina, Carlos; Espinoza, N.

2011-01-01

The world is facing unprecedented challenges related to energy resources, global climate change, material use, and waste generation. Failure to address these challenges will inhibit the growth of the developing world and will negatively impact the standard of living and security of future generations in all nations. The solutions to these challenges will require multidisciplinary research across the social and physical sciences and engineering. Although perhaps not always recognized, geotechnical engineering expertise is critical to the solution of many energy and sustainability-related problems. Hence, geotechnical engineers and academicians have opportunity and responsibility to contribute to the solution of these worldwidemore » problems. Research will need to be extended to non-standard issues such as thermal properties of soils; sediment and rock response to extreme conditions and at very long time scales; coupled hydro-chemo-thermo-bio-mechanical processes; positive feedback systems; the development of discontinuities; biological modification of soil properties; spatial variability; and emergent phenomena. Clearly, the challenges facing geotechnical engineering in the future will require a much broader knowledge base than our traditional educational programs provide. The geotechnical engineering curricula, from undergraduate education through continuing professional education, must address the changing needs of a profession that will increasingly be engaged in alternative/renewable energy production; energy efficiency; sustainable design, enhanced and more efficient use of natural resources, waste management, and underground utilization.« less

Numerical methods for incompressible viscous flows with engineering applications

NASA Technical Reports Server (NTRS)

Rose, M. E.; Ash, R. L.

1988-01-01

A numerical scheme has been developed to solve the incompressible, 3-D Navier-Stokes equations using velocity-vorticity variables. This report summarizes the development of the numerical approximation schemes for the divergence and curl of the velocity vector fields and the development of compact schemes for handling boundary and initial boundary value problems.

Numerical Package in Computer Supported Numeric Analysis Teaching

ERIC Educational Resources Information Center

Tezer, Murat

2007-01-01

At universities in the faculties of Engineering, Sciences, Business and Economics together with higher education in Computing, it is stated that because of the difficulty, calculators and computers can be used in Numerical Analysis (NA). In this study, the learning computer supported NA will be discussed together with important usage of the…

40 CFR Table 7 to Subpart Zzzz of... - Requirements for Reports

Code of Federal Regulations, 2010 CFR

2010-07-01

... engines that are not limited use stationary CI RICE subject to numerical emission limitations; andii... CI RICE subject to numerical emission limitations. b. If you had a deviation from any emission...

A two-dimensional numerical study of the flow inside the combustion chambers of a motored rotary engine

NASA Technical Reports Server (NTRS)

Shih, T. I. P.; Yang, S. L.; Schock, H. J.

1986-01-01

A numerical study was performed to investigate the unsteady, multidimensional flow inside the combustion chambers of an idealized, two-dimensional, rotary engine under motored conditions. The numerical study was based on the time-dependent, two-dimensional, density-weighted, ensemble-averaged conservation equations of mass, species, momentum, and total energy valid for two-component ideal gas mixtures. The ensemble-averaged conservation equations were closed by a K-epsilon model of turbulence. This K-epsilon model of turbulence was modified to account for some of the effects of compressibility, streamline curvature, low-Reynolds number, and preferential stress dissipation. Numerical solutions to the conservation equations were obtained by the highly efficient implicit-factored method of Beam and Warming. The grid system needed to obtain solutions were generated by an algebraic grid generation technique based on transfinite interpolation. Results of the numerical study are presented in graphical form illustrating the flow patterns during intake, compression, gaseous fuel injection, expansion, and exhaust.

A two-dimensional numerical study of the flow inside the combustion chamber of a motored rotary engine

NASA Technical Reports Server (NTRS)

Shih, T. I-P.; Yang, S. L.; Schock, H. J.

1986-01-01

A numerical study was performed to investigate the unsteady, multidimensional flow inside the combustion chambers of an idealized, two-dimensional, rotary engine under motored conditions. The numerical study was based on the time-dependent, two-dimensional, density-weighted, ensemble-averaged conservation equations of mass, species, momentum, and total energy valid for two-component ideal gas mixtures. The ensemble-averaged conservation equations were closed by a K-epsilon model of turbulence. This K-epsilon model of turbulence was modified to account for some of the effects of compressibility, streamline curvature, low-Reynolds number, and preferential stress dissipation. Numerical solutions to the conservation equations were obtained by the highly efficient implicit-factored method of Beam and Warming. The grid system needed to obtain solutions were generated by an algebraic grid generation technique based on transfinite interpolation. Results of the numerical study are presented in graphical form illustrating the flow patterns during intake, compression, gaseous fuel injection, expansion, and exhaust.

Activities of the Institute for Computer Applications in Science and Engineering

NASA Technical Reports Server (NTRS)

1985-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period April 1, 1985 through October 2, 1985 is summarized.

Engineering Ethics Education : Its Necessity, Objectives, Methods, Current State, and Challenges

NASA Astrophysics Data System (ADS)

Fudano, Jun

The importance of engineering ethics education has become widely recognized in the industrialized countries including Japan. This paper examines the background against which engineering ethics education is required, and reviews its objectives, methods, and challenges, as well as its current state. In pointing out important issues associated with the apparent acceptance and quantitative development of ethics education, especially after the establishment of the Japan Accreditation Board for Engineering Education in 1999, the author stresses that the most serious problem is the lack of common understanding on the objectives of engineering ethics education. As a strategy to improve the situation, the so-called “Ethics-across-the-Curriculum” approach is introduced. The author also claims that business/organization ethics which is consistent with engineering ethics should be promoted in Japan.

Tool for the Integrated Dynamic Numerical Propulsion System Simulation (NPSS)/Turbine Engine Closed-Loop Transient Analysis (TTECTrA) User's Guide

NASA Technical Reports Server (NTRS)

Chin, Jeffrey C.; Csank, Jeffrey T.

2016-01-01

The Tool for Turbine Engine Closed-Loop Transient Analysis (TTECTrA ver2) is a control design tool thatenables preliminary estimation of transient performance for models without requiring a full nonlinear controller to bedesigned. The program is compatible with subsonic engine models implemented in the MATLAB/Simulink (TheMathworks, Inc.) environment and Numerical Propulsion System Simulation (NPSS) framework. At a specified flightcondition, TTECTrA will design a closed-loop controller meeting user-defined requirements in a semi or fully automatedfashion. Multiple specifications may be provided, in which case TTECTrA will design one controller for each, producing acollection of controllers in a single run. Each resulting controller contains a setpoint map, a schedule of setpointcontroller gains, and limiters; all contributing to transient characteristics. The goal of the program is to providesteady-state engine designers with more immediate feedback on the transient engine performance earlier in the design cycle.

Higher-order compositional modeling of three-phase flow in 3D fractured porous media based on cross-flow equilibrium

NASA Astrophysics Data System (ADS)

Moortgat, Joachim; Firoozabadi, Abbas

2013-10-01

Numerical simulation of multiphase compositional flow in fractured porous media, when all the species can transfer between the phases, is a real challenge. Despite the broad applications in hydrocarbon reservoir engineering and hydrology, a compositional numerical simulator for three-phase flow in fractured media has not appeared in the literature, to the best of our knowledge. In this work, we present a three-phase fully compositional simulator for fractured media, based on higher-order finite element methods. To achieve computational efficiency, we invoke the cross-flow equilibrium (CFE) concept between discrete fractures and a small neighborhood in the matrix blocks. We adopt the mixed hybrid finite element (MHFE) method to approximate convective Darcy fluxes and the pressure equation. This approach is the most natural choice for flow in fractured media. The mass balance equations are discretized by the discontinuous Galerkin (DG) method, which is perhaps the most efficient approach to capture physical discontinuities in phase properties at the matrix-fracture interfaces and at phase boundaries. In this work, we account for gravity and Fickian diffusion. The modeling of capillary effects is discussed in a separate paper. We present the mathematical framework, using the implicit-pressure-explicit-composition (IMPEC) scheme, which facilitates rigorous thermodynamic stability analyses and the computation of phase behavior effects to account for transfer of species between the phases. A deceptively simple CFL condition is implemented to improve numerical stability and accuracy. We provide six numerical examples at both small and larger scales and in two and three dimensions, to demonstrate powerful features of the formulation.

Direct numerical simulation and reduced-order modeling of the sound-induced flow through a cavity-backed circular under a turbulent boundary layer

NASA Astrophysics Data System (ADS)

Zhang, Qi; Bodony, Daniel

2014-11-01

Commercial jet aircraft generate undesirable noise from several sources, with the engines being the most dominant sources at take-off and major contributors at all other stages of flight. Acoustic liners, which are perforated sheets of metal or composite mounted within the engine, have been an effective means of reducing internal engine noise from the fan, compressor, combustor, and turbine but their performance suffers when subjected to a turbulent grazing flow or to high-amplitude incident sound due to poorly understood interactions between the liner orifices and the exterior flow. Through the use of direct numerical simulations, the flow-orifice interaction is examined numerically, quantified, and modeled over a range of conditions that includes current and envisioned uses of acoustic liners and with detail that exceeds experimental capabilities. A new time-domain model of acoustic liners is developed that extends currently-available reduced-order models to more complex flow conditions but is still efficient for use at the design stage.

Crossing the Communication Barrier: Facilitating Communication in Mixed Groups of Deaf and Hearing Students

ERIC Educational Resources Information Center

Marchetti, Carol; Foster, Susan; Long, Gary; Stinson, Michael

2012-01-01

Teachers of introductory technical courses such as statistics face numerous challenges in the classroom, including student motivation and mathematical background, and difficulties in interpreting numerical results in context. Cooperative learning through small groups addresses many such challenges, but students for whom spoken English is not their…

NASA Propulsion Investments for Exploration and Science

NASA Technical Reports Server (NTRS)

Smith, Bryan K.; Free, James M.; Klem, Mark D.; Priskos, Alex S.; Kynard, Michael H.

2008-01-01

The National Aeronautics and Space Administration (NASA) invests in chemical and electric propulsion systems to achieve future mission objectives for both human exploration and robotic science. Propulsion system requirements for human missions are derived from the exploration architecture being implemented in the Constellation Program. The Constellation Program first develops a system consisting of the Ares I launch vehicle and Orion spacecraft to access the Space Station, then builds on this initial system with the heavy-lift Ares V launch vehicle, Earth departure stage, and lunar module to enable missions to the lunar surface. A variety of chemical engines for all mission phases including primary propulsion, reaction control, abort, lunar ascent, and lunar descent are under development or are in early risk reduction to meet the specific requirements of the Ares I and V launch vehicles, Orion crew and service modules, and Altair lunar module. Exploration propulsion systems draw from Apollo, space shuttle, and commercial heritage and are applied across the Constellation architecture vehicles. Selection of these launch systems and engines is driven by numerous factors including development cost, existing infrastructure, operations cost, and reliability. Incorporation of green systems for sustained operations and extensibility into future systems is an additional consideration for system design. Science missions will directly benefit from the development of Constellation launch systems, and are making advancements in electric and chemical propulsion systems for challenging deep space, rendezvous, and sample return missions. Both Hall effect and ion electric propulsion systems are in development or qualification to address the range of NASA s Heliophysics, Planetary Science, and Astrophysics mission requirements. These address the spectrum of potential requirements from cost-capped missions to enabling challenging high delta-v, long-life missions. Additionally, a high specific impulse chemical engine is in development that will add additional capability to performance-demanding space science missions. In summary, the paper provides a survey of current NASA development and risk reduction propulsion investments for exploration and science.

Train Like an Astronaut Educational Outreach

NASA Technical Reports Server (NTRS)

Garcia, Yamil L.; Lloyd, Charles; Reeves, Katherine M.; Abadie, Laurie J.

2012-01-01

In an effort to reduce the incidence of childhood obesity, the National Aeronautics and Space Administration (NASA), capitalizing on the theme of human spaceflight developed two educational outreach programs for children ages 8-12. To motivate young "fit explorers," the Train Like an Astronaut National (TLA) program and the Mission X: Train Like an Astronaut International Fitness Challenge (MX) were created. Based on the astronauts' physical training, these programs consist of activities developed by educators and experts in the areas of space life sciences and fitness. These Activities address components of physical fitness. The educational content hopes to promote students to pursue careers in science, technology, engineering, and math (STEM) fields. At the national level, in partnership with First Lady Michelle Obama's Let?s Move! Initiative, the TLA program consists of 10 physical and 2 educational activities. The program encourages families, schools, and communities to work collaboratively in order to reinforce in children and their families the importance of healthy lifestyle habits In contrast, the MX challenge is a cooperative outreach program involving numerous space agencies and other international partner institutions. During the six-week period, teams of students from around the world are challenged to improve their physical fitness and collectively accumulate points by completing 18 core activities. During the 2011 pilot year, a t otal of 137 teams and more than 4,000 students from 12 countries participated in the event. MX will be implemented within 24 countries during the 2012 challenge. It is projected that 7,000 children will "train like an astronaut".

A suite of benchmark and challenge problems for enhanced geothermal systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, Mark; Fu, Pengcheng; McClure, Mark

A diverse suite of numerical simulators is currently being applied to predict or understand the performance of enhanced geothermal systems (EGS). To build confidence and identify critical development needs for these analytical tools, the United States Department of Energy, Geothermal Technologies Office sponsored a Code Comparison Study (GTO-CCS), with participants from universities, industry, and national laboratories. A principal objective for the study was to create a community forum for improvement and verification of numerical simulators for EGS modeling. Teams participating in the study were those representing U.S. national laboratories, universities, and industries, and each team brought unique numerical simulation capabilitiesmore » to bear on the problems. Two classes of problems were developed during the study, benchmark problems and challenge problems. The benchmark problems were structured to test the ability of the collection of numerical simulators to solve various combinations of coupled thermal, hydrologic, geomechanical, and geochemical processes. This class of problems was strictly defined in terms of properties, driving forces, initial conditions, and boundary conditions. The challenge problems were based on the enhanced geothermal systems research conducted at Fenton Hill, near Los Alamos, New Mexico, between 1974 and 1995. The problems involved two phases of research, stimulation, development, and circulation in two separate reservoirs. The challenge problems had specific questions to be answered via numerical simulation in three topical areas: 1) reservoir creation/stimulation, 2) reactive and passive transport, and 3) thermal recovery. Whereas the benchmark class of problems were designed to test capabilities for modeling coupled processes under strictly specified conditions, the stated objective for the challenge class of problems was to demonstrate what new understanding of the Fenton Hill experiments could be realized via the application of modern numerical simulation tools by recognized expert practitioners. We present the suite of benchmark and challenge problems developed for the GTO-CCS, providing problem descriptions and sample solutions.« less

Exploration Design Challenge 2014

NASA Image and Video Library

2014-04-25

Lockheed Martin CEO Marillyn Hewson spoke at the Orion exhibit at the USA Science and Engineering Festival on April 25, 2014. The event was held to announce the winner of the Exploration Design Challenge. The goal of the Exploration Design Challenge was for students to research and design ways to protect astronauts from space radiation.The USA Science and Engineering Festival is taking place at the Washington Convention Center in Washington, DC on April 26 and 27, 2014. Photo Credit: (NASA/Aubrey Gemignani)

Exploration Design Challenge 2014

NASA Image and Video Library

2014-04-25

NASA Administrator Charles Bolden spoke at the Orion exhibit at the USA Science and Engineering Festival on April 25, 2014. The event was held to announce the winner of the Exploration Design Challenge. The goal of the Exploration Design Challenge was for students to research and design ways to protect astronauts from space radiation.The USA Science and Engineering Festival is taking place at the Washington Convention Center in Washington, DC on April 26 and 27, 2014. Photo Credit: (NASA/Aubrey Gemignani)

The Engineering 4 Health Challenge - an interdisciplinary and intercultural initiative to foster student engagement in B.C. and improve health care for children in under-serviced communities.

PubMed

Price, Morgan; Weber-Jahnke, Jens H

2009-01-01

This paper describes the Engineering 4 Health (E4H) Challenge, an interdisciplinary and intercultural initiative that, on the one hand, seeks to improve health education of children in under-serviced communities and, on the other, seeks to attract students in British Columbia to professions in engineering and health. The E4H Challenge engages high school and university students in BC to cooperatively design and develop health information and communication technology (ICT) to educate children living in under-serviced communities. The E4H Challenge works with the One Laptop Per Child (OLPC) program to integrate applications for health awareness into the school programs of communities in developing countries. Although applications developed by the E4H Challenge use the low-cost, innovative XO laptop (the "$100 laptop" developed by the OLPC foundation) the software can also be used with other inexpensive hardware.

Overview of the Mars Science Laboratory mission: Bradbury Landing to Yellowknife Bay and beyond

NASA Astrophysics Data System (ADS)

Vasavada, A. R.; Grotzinger, J. P.; Arvidson, R. E.; Calef, F. J.; Crisp, J. A.; Gupta, S.; Hurowitz, J.; Mangold, N.; Maurice, S.; Schmidt, M. E.; Wiens, R. C.; Williams, R. M. E.; Yingst, R. A.

2014-06-01

The Mars Science Laboratory mission reached Bradbury Landing in August 2012. In its first 500 sols, the rover Curiosity was commissioned and began its investigation of the habitability of past and present environments within Gale Crater. Curiosity traversed eastward toward Glenelg, investigating a boulder with a highly alkaline basaltic composition, encountering numerous exposures of outcropping pebble conglomerate, and sampling aeolian sediment at Rocknest and lacustrine mudstones at Yellowknife Bay. On sol 324, the mission turned its focus southwest, beginning a year-long journey to the lower reaches of Mt. Sharp, with brief stops at the Darwin and Cooperstown waypoints. The unprecedented complexity of the rover and payload systems posed challenges to science operations, as did a number of anomalies. Operational processes were revised to include additional opportunities for advance planning by the science and engineering teams.