The Brightening of the Red Supergiant alpha Ori

NASA Astrophysics Data System (ADS)

Wasatonic, R. P.; Guinan, E. F.

2016-09-01

We have been carrying out V-band and Wing TiO-band and Near-IR photoelectric photometry of the semi-regular variable red supergiant alpha Ori (Betelgeuse) over last 20 yrs. Photometry obtained during early to mid September 2016 indicates that the star is at (or near) maximum light at = +0.29 mag. Measures of TiO-band and near-IR colors indicate that alpha Ori has undergone a temperature increase of about +120 K and has an estimated spectral type of M0.5 Iab. Because alpha Ori is one of the nearest Type II SN progenitors, it an important star to monitor.

Kepler-1647b: The Largest and Longest-period Kepler Transiting Circumbinary Planet

NASA Astrophysics Data System (ADS)

Kostov, Veselin B.; Orosz, Jerome A.; Welsh, William F.; Doyle, Laurance R.; Fabrycky, Daniel C.; Haghighipour, Nader; Quarles, Billy; Short, Donald R.; Cochran, William D.; Endl, Michael; Ford, Eric B.; Gregorio, Joao; Hinse, Tobias C.; Isaacson, Howard; Jenkins, Jon M.; Jensen, Eric L. N.; Kane, Stephen; Kull, Ilya; Latham, David W.; Lissauer, Jack J.; Marcy, Geoffrey W.; Mazeh, Tsevi; Müller, Tobias W. A.; Pepper, Joshua; Quinn, Samuel N.; Ragozzine, Darin; Shporer, Avi; Steffen, Jason H.; Torres, Guillermo; Windmiller, Gur; Borucki, William J.

2016-08-01

We report the discovery of a new Kepler transiting circumbinary planet (CBP). This latest addition to the still-small family of CBPs defies the current trend of known short-period planets orbiting near the stability limit of binary stars. Unlike the previous discoveries, the planet revolving around the eclipsing binary system Kepler-1647 has a very long orbital period (˜1100 days) and was at conjunction only twice during the Kepler mission lifetime. Due to the singular configuration of the system, Kepler-1647b is not only the longest-period transiting CBP at the time of writing, but also one of the longest-period transiting planets. With a radius of 1.06 ± 0.01 R Jup, it is also the largest CBP to date. The planet produced three transits in the light curve of Kepler-1647 (one of them during an eclipse, creating a syzygy) and measurably perturbed the times of the stellar eclipses, allowing us to measure its mass, 1.52 ± 0.65 M Jup. The planet revolves around an 11-day period eclipsing binary consisting of two solar-mass stars on a slightly inclined, mildly eccentric (e bin = 0.16), spin-synchronized orbit. Despite having an orbital period three times longer than Earth’s, Kepler-1647b is in the conservative habitable zone of the binary star throughout its orbit.

The Circumstellar Disk and Asymmetric Outflow of the EX Lup Outburst System

NASA Astrophysics Data System (ADS)

Hales, A. S.; Pérez, S.; Saito, M.; Pinte, C.; Knee, L. B. G.; de Gregorio-Monsalvo, I.; Dent, B.; López, C.; Plunkett, A.; Cortés, P.; Corder, S.; Cieza, L.

2018-06-01

We present Atacama Large Millimeter/submillimeter Array (ALMA) observations at 0.″3 resolution of EX Lup, the prototype of the EXor class of outbursting pre-main-sequence stars. The circumstellar disk of EX Lup is resolved for the first time in 1.3 mm continuum emission and in the J = 2–1 spectral line of three isotopologues of CO. At the spatial resolution and sensitivity achieved, the compact dust continuum disk shows no indications of clumps, fragments, or asymmetries above the 5σ level. Radiative transfer modeling constrains the characteristic radius of the dust disk to 23 au and the total dust mass to 1.0 × 10‑4 M ⊙ (33 M ⊕), similar to other EXor sources. The 13CO and C18O line emissions trace the disk rotation and are used to constrain the disk geometry, kinematics, and a total gas disk mass of 5.1 × 10‑4 M ⊙. The 12CO emission extends out to a radius of 200 au and is asymmetric, with one side deviating from Keplerian rotation. We detect blueshifted, 12CO arc-like emission located 0.″8 to the northwest and spatially disconnected from the disk emission. We interpret this extended structure as the brightened walls of a cavity excavated by an outflow, which are more commonly seen in FUor sources. Such outflows have also been seen in the borderline FU/EXor object V1647 Ori, but not toward EXor objects. Our detection provides evidence that the outflow phenomenon persists into the EXor phase, suggesting that FUor and EXor objects are a continuous population in which outflow activity declines with age, with transitional objects such as EX Lup and V1647 Ori.

40 CFR 164.7 - Ex parte discussion of proceeding.

Code of Federal Regulations, 2011 CFR

2011-07-01

....7 Section 164.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE... ACT, ARISING FROM REFUSALS TO REGISTER, CANCELLATIONS OF REGISTRATIONS, CHANGES OF CLASSIFICATIONS... Environmental Appeals Board, the Presiding Officer, or the Administrative Law Judge discuss ex parte the merits...

40 CFR 164.7 - Ex parte discussion of proceeding.

Code of Federal Regulations, 2010 CFR

2010-07-01

....7 Section 164.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE... ACT, ARISING FROM REFUSALS TO REGISTER, CANCELLATIONS OF REGISTRATIONS, CHANGES OF CLASSIFICATIONS... Environmental Appeals Board, the Presiding Officer, or the Administrative Law Judge discuss ex parte the merits...

Māori identity signatures: A latent profile analysis of the types of Māori identity.

PubMed

Greaves, Lara M; Houkamau, Carla; Sibley, Chris G

2015-10-01

Māori are the indigenous peoples of New Zealand. However, the term 'Māori' can refer to a wide range of people of varying ethnic compositions and cultural identity. We present a statistical model identifying 6 distinct types, or 'Māori Identity Signatures,' and estimate their proportion in the Māori population. The model is tested using a Latent Profile Analysis of a national probability sample of 686 Māori drawn from the New Zealand Attitudes and Values Study. We identify 6 distinct signatures: Traditional Essentialists (22.6%), Traditional Inclusives (16%), High Moderates (31.7%), Low Moderates (18.7%), Spiritually Orientated (4.1%), and Disassociated (6.9%). These distinct Identity Signatures predicted variation in deprivation, age, mixed-ethnic affiliation, and religion. This research presents the first formal statistical model assessing how people's identity as Māori is psychologically structured, documents the relative proportion of these different patterns of structures, and shows that these patterns reliably predict differences in core demographics. We identify a range of patterns of Māori identity far more diverse than has been previously proposed based on qualitative data, and also show that the majority of Māori fit a moderate or traditional identity pattern. The application of our model for studying Māori health and identity development is discussed. (c) 2015 APA, all rights reserved).

Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function.

PubMed

Wong, S W; Schaffer, P A

1991-05-01

Like other DNA-containing viruses, the three origins of herpes simplex virus type 1 (HSV-1) DNA replication are flanked by sequences containing transcriptional regulatory elements. In a transient plasmid replication assay, deletion of sequences comprising the transcriptional regulatory elements of ICP4 and ICP22/47, which flank oriS, resulted in a greater than 80-fold decrease in origin function compared with a plasmid, pOS-822, which retains these sequences. In an effort to identify specific cis-acting elements responsible for this effect, we conducted systematic deletion analysis of the flanking region with plasmid pOS-822 and tested the resulting mutant plasmids for origin function. Stimulation by cis-acting elements was shown to be both distance and orientation dependent, as changes in either parameter resulted in a decrease in oriS function. Additional evidence for the stimulatory effect of flanking sequences on origin function was demonstrated by replacement of these sequences with the cytomegalovirus immediate-early promoter, resulting in nearly wild-type levels of oriS function. In competition experiments, cotransfection of cells with the test plasmid, pOS-822, and increasing molar concentrations of a competitor plasmid which contained the ICP4 and ICP22/47 transcriptional regulatory regions but lacked core origin sequences resulted in a significant reduction in the replication efficiency of pOS-822, demonstrating that factors which bind specifically to the oriS-flanking sequences are likely involved as auxiliary proteins in oriS function. Together, these studies demonstrate that trans-acting factors and the sites to which they bind play a critical role in the efficiency of HSV-1 DNA replication from oriS in transient-replication assays.

Engagement and recruitment of Māori and non-Māori people of advanced age to LiLACS NZ.

PubMed

Dyall, Lorna; Kepa, Mere; Hayman, Karen; Teh, Ruth; Moyes, Simon; Broad, Joanna B; Kerse, Ngaire

2013-04-01

Life and Living in Advanced Age: A Cohort Study in New Zealand (LiLACS NZ) aims to determine the predictors of successful advanced ageing and understand the trajectories of wellbeing in advanced age. This paper reports recruitment strategies used to enrol 600 Māori aged 80-90 years and 600 non-Māori aged 85 years living within a defined geographic boundary. Electoral roll and primary health lists of older people were used as a base for identification and recruitment, supplemented by word of mouth, community awareness raising and publicity. A Kaupapa Māori method was used to recruit Māori with: dual Māori and non-Māori research leadership; the formation of a support group; local tribal organisations and health providers recruiting participants; and use of the Māori language in interviews. Non-Māori were recruited through local health and community networks. Six organisations used differing strategies to invite older people to participate in several ways: complete full or partial interviews; complete physical assessments; provide a blood sample and provide access to medical records. During 14 months in 2010-2011, 421 of 766 (56%) eligible Māori and 516 of 870 (59%) eligible non-Māori were enrolled. Participation and contribution of information varied across the recruitment sites. Attention to appropriate recruitment techniques resulted in an acceptable engagement and recruitment for both Māori and non-Māori of advanced age in a longitudinal cohort study. There is high potential for meaningful results useful for participants, their whānau and families, health agencies, planners and policy. © 2013 The Authors. ANZJPH © 2013 Public Health Association of Australia.

Photometric variability in FU Ori and Z CMa as observed by MOST

NASA Astrophysics Data System (ADS)

Siwak, Michal; Rucinski, Slavek M.; Matthews, Jaymie M.; Kuschnig, Rainer; Guenther, David B.; Moffat, Anthony F. J.; Rowe, Jason F.; Sasselov, Dimitar; Weiss, Werner W.

2013-06-01

Photometric observations obtained by the MOST satellite were used to characterize optical small-scale variability of the young stars FU Ori and Z CMa. Wavelet analysis for FU Ori reveals the possible existence of several 2-9 d quasi-periodic features occurring nearly simultaneously; they may be interpreted as plasma parcels or other localized disc heterogeneities revolving at different Keplerian radii in the accretion disc. Their periods may shorten slowly which may be due to spiralling in of individual parcels towards the inner disc radius, estimated at 4.8 ± 0.2 R⊙. Analysis of additional multicolour data confirms the previously obtained relation between variations in the B - V colour index and the V magnitude. In contrast to the FU Ori results, the oscillation spectrum of Z CMa does not reveal any periodicities with the wavelet spectrum possibly dominated by outburst of the Herbig Be component.

Inequities in exposure to occupational risk factors between Māori and non-Māori workers in Aotearoa New Zealand.

PubMed

Denison, Hayley J; Eng, Amanda; Barnes, Lucy A; Cheng, Soo; 't Mannetje, Andrea; Haddock, Katharine; Douwes, Jeroen; Pearce, Neil; Ellison-Loschmann, Lis

2018-05-02

Health inequities between indigenous and non-indigenous people are well documented. However, the contribution of differential exposure to risk factors in the occupational environment remains unclear. This study assessed differences in the prevalence of self-reported exposure to disease risk factors, including dust and chemicals, physical factors and organisational factors, between Māori and non-Māori workers in New Zealand. Potential participants were sampled from the New Zealand electoral rolls and invited to take part in a telephone interview, which included questions about current workplace exposures. Logistic regression, accounting for differences in age, socioeconomic status and occupational distribution between Māori and non-Māori, was used to assess differences in exposures. In total, 2344 Māori and 2710 non-Māori participants were included in the analyses. Māori had greater exposure to occupational risk factors than non-Māori. For dust and chemical exposures, the main differences related to Māori working in occupations where these exposures are more common. However, even within the same job, Māori were more likely to be exposed to physical factors such as heavy lifting and loud noise, and organisational factors such as carrying out repetitive tasks and working to tight deadlines compared with non-Māori. This is one of the first studies internationally to compare occupational risk factors between indigenous and non-indigenous people. These findings suggest that the contribution of the occupational environment to health inequities between Māori and non-Māori has been underestimated and that work tasks may be unequally distributed according to ethnicity. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Enhancing Māori food security using traditional kai.

PubMed

McKerchar, Christina; Bowers, Sharron; Heta, Craig; Signal, Louise; Matoe, Leonie

2015-09-01

Lack of food security is one of the major nutrition issues facing Māori today. Loss of traditional kai (food) gathering places and practices following colonisation and urbanisation has impacted negatively on food security for Māori. This paper explores the role of Māori in enhancing Māori food security through revitalising traditional kai. A narrative literature review of peer reviewed and grey literature on revitalising traditional kai for Māori was conducted. The focus was on two areas: increasing the availability of traditional kai to Māori households (such as through replenishing fish stocks, and gardening projects) and increasing the financial means available to Māori households to purchase food (by economic development of traditional kai industries and employment creation). A range of activities to improve food security for Māori by revitalising traditional kai was identified in the literature. Māori are now significant players in New Zealand's fishing industry, and are developing their horticultural resources. Gardening initiatives have also grown considerably in Māori communities. Enabling factors included: the return of traditional kai resources by the Crown, and successful pursuit by Māori of the legal rights to develop them; development of Māori models of governance; government policy around Māori economic development and healthy eating; and Māori leadership on the issue. Barriers to revitalising traditional kai that remain to be addressed include: tensions between Government and Māori goals and models of resource management; economic pressures resulting in severely depleted fishing stocks; and pollution of marine and freshwater fish. Revitalising traditional kai has considerable potential to improve food security for Māori, both directly in terms of food supply and by providing income, and warrants policy and practical support. These findings have implications for other indigenous cultures who are struggling to be food secure. © The

Exercise to Support Indigenous Pregnant Women to Stop Smoking: Acceptability to Māori.

PubMed

Roberts, Vaughan; Glover, Marewa; McCowan, Lesley; Walker, Natalie; Ussher, Michael; Heke, Ihirangi; Maddison, Ralph

2017-11-01

Objectives Smoking during pregnancy is harmful for the woman and the unborn child, and the harms raise risks for the child going forward. Indigenous women often have higher rates of smoking prevalence than non-indigenous. Exercise has been proposed as a strategy to help pregnant smokers to quit. Māori (New Zealand Indigenous) women have high rates of physical activity suggesting that an exercise programme to aid quitting could be an attractive initiative. This study explored attitudes towards an exercise programme to aid smoking cessation for Māori pregnant women. Methods Focus groups with Māori pregnant women, and key stakeholder interviews were conducted. Results Overall, participants were supportive of the idea of a physical activity programme for pregnant Māori smokers to aid smoking cessation. The principal, over-arching finding, consistent across all participants, was the critical need for a Kaupapa Māori approach (designed and run by Māori, for Māori people) for successful programme delivery, whereby Māori cultural values are respected and infused throughout all aspects of the programme. A number of practical and environmental barriers to attendance were raised including: cost, the timing of the programme, accessibility, transport, and childcare considerations. Conclusions A feasibility study is needed to design an intervention following the suggestions presented in this paper with effort given to minimising the negative impact of barriers to attendance.

ABSENCE OF SIGNIFICANT COOL DISKS IN YOUNG STELLAR OBJECTS EXHIBITING REPETITIVE OPTICAL OUTBURSTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Hauyu Baobab; Hirano, Naomi; Takami, Michihiro

2016-01-10

We report Submillimeter Array 1.3 mm high angular resolution observations toward the four EXor-type outbursting young stellar objects VY Tau, V1118 Ori, V1143 Ori, and NY Ori. The data mostly show low dust masses M{sub dust} in the associated circumstellar disks. Among the sources, NY Ori possesses a relatively massive disk with M{sub dust} ∼ 9 × 10{sup −4}M{sub ⊙}. V1118 Ori has a marginal detection equivalent to M{sub dust} ∼ 6 × 10{sup −5}M{sub ⊙}. V1143 Ori has a non-detection also equivalent to M{sub dust} < 6 × 10{sup −5}M{sub ⊙}. For the nearest source, VY Tau, we get a surprising non-detection that provides a stringent upper limit M{sub dust} < 6 × 10{sup −6}M{sub ⊙}.more » We interpret our findings as suggesting that the gas and dust reservoirs that feed the short-duration, repetitive optical outbursts seen in some EXors may be limited to the small-scale, innermost region of their circumstellar disks. This hot dust may have escaped our detection limits. Follow-up, more sensitive millimeter observations are needed to improve our understanding of the triggering mechanisms of EXor-type outbursts.« less

Varicella-zoster virus (VZV) origin of DNA replication oriS influences origin-dependent DNA replication and flanking gene transcription.

PubMed

Khalil, Mohamed I; Sommer, Marvin H; Hay, John; Ruyechan, William T; Arvin, Ann M

2015-07-01

The VZV genome has two origins of DNA replication (oriS), each of which consists of an AT-rich sequence and three origin binding protein (OBP) sites called Box A, C and B. In these experiments, the mutation in the core sequence CGC of the Box A and C not only inhibited DNA replication but also inhibited both ORF62 and ORF63 expression in reporter gene assays. In contrast the Box B mutation did not influence DNA replication or flanking gene transcription. These results suggest that efficient DNA replication enhances ORF62 and ORF63 transcription. Recombinant viruses carrying these mutations in both sites and one with a deletion of the whole oriS were constructed. Surprisingly, the recombinant virus lacking both copies of oriS retained the capacity to replicate in melanoma and HELF cells suggesting that VZV has another origin of DNA replication. Copyright © 2015 Elsevier Inc. All rights reserved.

Vitamin D status of Māori and non-Māori octogenarians in New Zealand: a Cohort Study (LiLACS NZ).

PubMed

Bacon, Catherine J; Kerse, Ngaire; Hayman, Karen J; Moyes, Simon A; Teh, Ruth O; Kepa, Mere; Pillai, Avinesh; Dyall, Lorna

2016-12-01

This study assessed vitamin D status and its determinants in a cohort of octogenarians living within New Zealand's Bay of Plenty and Lakes Districts. Serum 25- hydroxyvitamin D [25(OH)D] concentration was measured in 209 Māori (aged 80-90 years) and 357 non-Māori (85 years), along with demographic, lifestyle, supplement use and other health data. Mean [95% CI] 25(OH)D concentration was 69 [67 to 72] nmol/L, with 15% >100 nmol/L and 6 individuals >150 nmol/L. Concentrations in Māori (59 [55 to 62] 4 nmol/L) were lower than in non-Māori (75 [72 to 78] nmol/L; p<0.001), a difference maintained when adjusted for day-of-year measured. Vitamin D supplementation was reported by 98 participants (18%): including a greater proportion of women (24%) than men (11%; p<0.001) and of non-Māori (24%) than Māori (7%; p<0.001). Of those taking vitamin D, 49% took high oral doses (>=25 μg/day or equivalent) and five individuals took >50 μg/day. Vitamin D supplement use strongly and independently predicted seasonally- adjusted 25(OH)D concentration and was associated with 28 nmol/L higher levels than non-use. Other predictors included Māori ethnicity (10 nmol/L lower concentration than for non-Māori), and female gender (11 nmol/L lower). Vitamin D status in New Zealand octogenarians appears higher than previously reported, particularly in non-Māori compared to Māori. Prescribed and non-prescribed oral vitamin D supplementation is prevalent in this group and a strong indicator of vitamin D status.

Optical Counterpart to MAXI J1647-227

NASA Astrophysics Data System (ADS)

Garnavich, P.; Magno, K.; Applegate, A.

2012-06-01

We observed the field of the X-ray transient MAXI J1647-227 (Negoro et al., ATEL#4175) with the Vatican Advance Technology Telescope (VATT) and VATT4K CCD imager beginning June 16.244 UT. R-band images reveal an optical source near the position of the Swift localization (Kennea et al., ATEL#4178) that is not visible on the Digitized Sky Survey. Based on USNO-B1.0 catalog stars in the field, we find the optical transient has a position of 16:48:12.32 -23:00:53.56 (error of 0.2 arcsec) which is within 2 arcsec of the Swift X-ray position.

28 CFR 16.47 - Requests for an accounting of record disclosures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 1974 § 16.47 Requests for an accounting of record disclosures. (a) How made and addressed. Except where accountings of disclosures are not required to be kept (as stated in paragraph (b) of this section), you may make a request for an accounting of any disclosure that has been made by the Department to another...

Electromyographic characteristic of orbicularis oris in patients with dental crowding in permanent occlusion.

PubMed

Dmytrenko, Maryna I; Kuroiedowa, Vira D

2016-01-01

electromyographic indices were developed for complex analysis of functional condition of orbicularis oris. to study electromyographic indices of orbicularis oris in patients with dental crowding in permanent occlusion. thirty four patients with malocclusion and a severe degree of severity of dental crowding (15 males, 19 females, aged 16-29 years) who underwent orthodontic examination. The treatment group was divided into three: Group Ia comprised 11 subjects with mandibular crowding (mean age 19,27 ± 1,08 years); group Ib, 10 patients with maxillary dental crowding (mean age 20,10 ± 1,60 years) and group Ic, 13 subjects with both maxillary and mandibular crowding (mean age 20,15 ± 1,45 years). The control group consisted of 10 patients with malocclusions but without dental crowding (mean age 20,70 ± 1,32 years). The findings were compared with similar indices in subjects with normal occlusion (mean age 21,3 ± 1,25 years). The index of orbicularis oris activity (ACTIV,%) was determined for each patient. A Student's t-test was used to analyze statistical difference between different groups. patients having crowding of maxillary teeth showed greater activity of muscles of the upper lip during maximum voluntary clenching (АCTІV= -0,99±7,44%). Activity of the muscles of the lower lip in patients with crowding of mandibular teeth (АСTІV=20,52±4,22%) and crowding of maxillary and mandibular teeth (АСTІV=17,93±4,33%) is prevailing. аctivity of the orbicularis oris in patients with malocclusion, complicated by dental crowding depend on clinical localization of crowding.

Electromyographic characteristic of orbicularis oris in patients with dental crowding in permanent occlusion.

PubMed

Dmytrenko, Maryna I; Kuroiedowa, Vira D

electromyographic indices were developed for complex analysis of functional condition of orbicularis oris. to study electromyographic indices of orbicularis oris in patients with dental crowding in permanent occlusion. thirty four patients with malocclusion and a severe degree of severity of dental crowding (15 males, 19 females, aged 16-29 years) who underwent orthodontic examination. The treatment group was divided into three: Group Ia comprised 11 subjects with mandibular crowding (mean age 19,27 ± 1,08 years); group Ib, 10 patients with maxillary dental crowding (mean age 20,10 ± 1,60 years) and group Ic, 13 subjects with both maxillary and mandibular crowding (mean age 20,15 ± 1,45 years). The control group consisted of 10 patients with malocclusions but without dental crowding (mean age 20,70 ± 1,32 years). The findings were compared with similar indices in subjects with normal occlusion (mean age 21,3 ± 1,25 years). The index of orbicularis oris activity (ACTIV,%) was determined for each patient. A Student's t-test was used to analyze statistical difference between different groups. patients having crowding of maxillary teeth showed greater activity of muscles of the upper lip during maximum voluntary clenching (АCTІV= -0,99±7,44%). Activity of the muscles of the lower lip in patients with crowding of mandibular teeth (АСTІV=20,52±4,22%) and crowding of maxillary and mandibular teeth (АСTІV=17,93±4,33%) is prevailing. аctivity of the orbicularis oris in patients with malocclusion, complicated by dental crowding depend on clinical localization of crowding.

High-Resolution Near-Infrared Spectroscopy of FU Orionis Objects

NASA Astrophysics Data System (ADS)

Hartmann, Lee; Hinkle, Kenneth; Calvet, Nuria

2004-07-01

We present an analysis of recent near-infrared, high-resolution spectra of the variable FU Ori objects. During a phase of rapid fading in optical brightness during 1997, V1057 Cyg exhibited shell absorption in first-overtone (v''-v'=2-0) CO lines, blueshifted by about 50 km s-1 from the system velocity. This shell component had not been seen previously, nor was it present in 1999, although some blueshifted absorption asymmetry is seen at the latter epoch. The appearance of this CO absorption shell is connected with the roughly contemporaneous appearance of blueshifted, low-excitation optical absorption lines with comparable low velocities; we suggest that this shell was also responsible for some of the peculiar emission features seen in red-optical spectra of V1057 Cyg. FU Ori continues to exhibit broad CO lines, with some evidence for the double-peaked profiles characteristic of an accretion disk; the line profiles are consistent with previous observations. Both FU Ori and V1057 Cyg continue to exhibit lower rotational broadening at 2.3 μm than at optical wavelengths, in agreement with the prediction of differentially rotating disk models; we have a marginal detection of the same effect in V1515 Cyg. The relative population of the first-overtone CO rotational levels in the FU Ori objects suggests low excitation temperatures. We compare disk models to the observations and find agreement with overall line strengths and rotational broadening, but the observed line profiles are generally less double-peaked than predicted. We suggest that the discrepancy in line profiles is due to turbulent motions in FU Ori disks, an effect qualitatively predicted by recent simulations of the magnetorotational instability in vertically stratified accretion disks. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy (AURA), Inc., under a cooperative agreement with the NSF, on behalf of the Gemini

Biotechnology: the language of multiple views in Māori communities.

PubMed

Te Momo, O H Fiona

2007-09-01

In Aotearoa (New Zealand), the government funded studies on communicating biotechnology to different sectors in the community from 2003 to 2006. Subsequently, a researcher covering the Māori sector performed a content analysis of data gathered in the community. Qualitative analysis methods included examining text from participant interviews, focus groups, government documents, newspapers, Internet sites, and current literature. Content was coded by identifying common themes in the English and the Māori language. Words like genetic modification (GM), genetic engineering (GE), and biotechnology were explained to provide a basic understanding between the communities and researcher. The terminology applied in the research was essential to achieve communication between the researcher and the community. The resultant themes represented seven views to interpret the communities association with biotechnology: purist Māori, religious Māori, anti Māori, pro Māori, no Māori, uncertain Māori, and middle Māori views. The themes are taken from the analysis of data compiled after 3 years of completing different stages of a research project. The views indicate that a common understanding can be achieved in the diverse range of Māori tribal communities providing those communicating biotechnology can identify the view and interpretations communities associate with biotechnology. This knowledge is essential for government agencies, researchers, community practitioners, scientist, and businesses that desire to dialogue with Māori communities in the language of biotechnology.

Translations on Near East and North Africa, Number 1647

DTIC Science & Technology

1977-04-28

Production capacity of the two plants is to amount to 220,000 tons of ammonia and 800,000 tons of uric acid . Improving operations efficiency at the...JPRS 69019 28 April 1977 TRANSLATIONS’ON NEAR EAST AND NORTH AFRICA No, 1647 < 2 w ÜJCEE »- .Q-5 ^ Q. C «MM H— —• £2 a« ES.Q...3. Recipient’s Accession No. 4. Title and Subtitle TRANSLATIONS ON NEAR EAST AND NORTH AFRICA , No. 164 7 5. Report Date 28 April 1977 6

Regions flanking ori sequences affect the replication efficiency of the mitochondrial genome of ori+ petite mutants from yeast.

PubMed

Rayko, E; Goursot, R; Cherif-Zahar, B; Melis, R; Bernardi, G

1988-03-31

The mitochondrial genomes of progenies from 26 crosses between 17 cytoplasmic, spontaneous, suppressive, ori+ petite mutants of Saccharomyces cerevisiae have been studied by electrophoresis of restriction fragments. Only parental genomes (or occasionally, genomes derived from them by secondary excisions) were found in the progenies of the almost 500 diploids investigated; no evidence for illegitimate, site-specific mitochondrial recombination was detected. One of the parental genomes was always found to be predominate over the other one, although to different extents in different crosses. This predominance appears to be due to a higher replication efficiency, which is correlated with a greater density of ori sequences on the mitochondrial genome (and with a shorter repeat unit size of the latter). Exceptions to the 'repeat-unit-size rule' were found, however, even when the parental mitochondrial genomes carried the same ori sequence. This indicates that noncoding, intergenic sequences outside ori sequences also play a role in modulating replication efficiency. Since in different petites such sequences differ in primary structure, size, and position relative to ori sequences, this modulation is likely to take place through an indirect effect on DNA and nucleoid structure.

ORBITAL AND PHYSICAL PROPERTIES OF THE σ Ori Aa, Ab, B TRIPLE SYSTEM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simón-Díaz, S.; Caballero, J. A.; Apellániz, J. Maíz

2015-02-01

We provide a complete characterization of the astrophysical properties of the σ Ori Aa, Ab, B hierarchical triple system and an improved set of orbital parameters for the highly eccentric σ Ori Aa, Ab spectroscopic binary. We compiled a spectroscopic data set comprising 90 high-resolution spectra covering a total time span of 1963 days. We applied the Lehman-Filhés method for a detailed orbital analysis of the radial velocity curves and performed a combined quantitative spectroscopic analysis of the σ Ori Aa, Ab, B system by means of the stellar atmosphere code FASTWIND. We used our own plus other available information onmore » photometry and distance to the system for measuring the radii, luminosities, and spectroscopic masses of the three components. We also inferred evolutionary masses and stellar ages using the Bayesian code BONNSAI. The orbital analysis of the new radial velocity curves led to a very accurate orbital solution of the σ Ori Aa, Ab pair. We provided indirect arguments indicating that σ Ori B is a fast-rotating early B dwarf. The FASTWIND+BONNSAI analysis showed that the Aa, Ab pair contains the hottest and most massive components of the triple system while σ Ori B is a bit cooler and less massive. The derived stellar ages of the inner pair are intriguingly younger than the one widely accepted for the σ Orionis cluster, at 3 ± 1 Ma. The outcome of this study will be of key importance for a precise determination of the distance to the σ Orionis cluster, the interpretation of the strong X-ray emission detected for σ Ori Aa, Ab, B, and the investigation of the formation and evolution of multiple massive stellar systems and substellar objects.« less

42 CFR 93.402 - ORI allegation assessments.

Code of Federal Regulations, 2010 CFR

2010-10-01

... RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.402 ORI allegation assessments. (a) When ORI receives an allegation of research misconduct directly or becomes aware of an allegation or apparent instance of research misconduct, it may...

Patterns of privilege: A total cohort analysis of admission and academic outcomes for Māori, Pacific and non-Māori non-Pacific health professional students.

PubMed

Wikaire, Erena; Curtis, Elana; Cormack, Donna; Jiang, Yannan; McMillan, Louise; Loto, Rob; Reid, Papaarangi

2016-10-07

Tertiary institutions are struggling to ensure equitable academic outcomes for indigenous and ethnic minority students in health professional study. This demonstrates disadvantaging of ethnic minority student groups (whereby Indigenous and ethnic minority students consistently achieve academic outcomes at a lower level when compared to non-ethnic minority students) whilst privileging non-ethnic minority students and has important implications for health workforce and health equity priorities. Understanding the reasons for academic inequities is important to improve institutional performance. This study explores factors that impact on academic success for health professional students by ethnic group. Kaupapa Māori methodology was used to analyse data for 2686 health professional students at the University of Auckland in 2002-2012. Data were summarised for admission variables: school decile, Rank Score, subject credits, Auckland school, type of admission, and bridging programme; and academic outcomes: first-year grade point average (GPA), first-year passed all courses, year 2 - 4 programme GPA, graduated, graduated in the minimum time, and composite completion for Māori, Pacific, and non-Māori non-Pacific (nMnP) students. Statistical tests were used to identify significant differences between the three ethnic groupings. Māori and Pacific students were more likely to attend low decile schools (27 % Māori, 33 % Pacific vs. 5 % nMnP, p < 0.01); complete bridging foundation programmes (43 % Māori, 50 % Pacific vs. 5 % nMnP, p < 0.01), and received lower secondary school results (Rank Score 197 Māori, 178 Pacific vs. 231 nMnP, p < 0.01) when compared with nMnP students. Patterns of privilege were seen across all academic outcomes, whereby nMnP students achieved higher first year GPA (3.6 Māori, 2.8 Pacific vs. 4.7 nMnP, p < 0.01); were more likely to pass all first year courses (61 % Māori, 41 % Pacific vs. 78 % nMnP, p < 0.01); to

42 CFR 93.403 - ORI review of research misconduct proceedings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false ORI review of research misconduct proceedings. 93... POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.403 ORI review of research misconduct proceedings. ORI may conduct reviews...

42 CFR 93.403 - ORI review of research misconduct proceedings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false ORI review of research misconduct proceedings. 93... POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.403 ORI review of research misconduct proceedings. ORI may conduct reviews...

42 CFR 93.403 - ORI review of research misconduct proceedings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false ORI review of research misconduct proceedings. 93... POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.403 ORI review of research misconduct proceedings. ORI may conduct reviews...

42 CFR 93.403 - ORI review of research misconduct proceedings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false ORI review of research misconduct proceedings. 93... POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.403 ORI review of research misconduct proceedings. ORI may conduct reviews...

42 CFR 93.403 - ORI review of research misconduct proceedings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false ORI review of research misconduct proceedings. 93... POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.403 ORI review of research misconduct proceedings. ORI may conduct reviews...

The CIDA Variability Survey of Orion OB1. I. The Low-Mass Population of Ori OB1a and 1b

NASA Astrophysics Data System (ADS)

Briceño, Cesar; Calvet, Nuria; Hernández, J.; Vivas, A. K.; Hartmann, Lee; Downes, J. J.; Berlind, Perry

2005-02-01

We present results of a large-scale, multiepoch optical survey of the Orion OB1 association, carried out with the QUEST camera at the Venezuela National Astronomical Observatory. We identify for the first time the widely spread low-mass, young population in the Ori OB1a and OB1b subassociations. Candidate members were picked up by their variability in the V band and position in color-magnitude diagrams. We obtained spectra to confirm membership. In a region spanning ~68 deg2, we found 197 new young stars; of these, 56 are located in the Ori OB1a subassociation and 141 in Ori OB1b. The spatial distribution of the low-mass young stars is spatially coincident with that of the high-mass members but suggests a much sharper edge to the association. Comparison with the spatial extent of molecular gas and extinction maps indicates that the subassociation Ori OB1b is concentrated within a ringlike structure of radius ~2°(~15 pc at 440 pc), centered roughly on the star ɛ Ori in the Orion belt. The ring is apparent in 13CO and corresponds to a region with an extinction AV>=1. The stars exhibiting strong Hα emission, an indicator of active accretion, are found along this ring, whereas the center is populated with weak Hα-emitting stars. In contrast, Ori OB1a is located in a region devoid of gas and dust. We identify a grouping of stars within a ~3 deg2 area located in Ori OB1a, roughly clustered around the B2 star 25 Ori. The Herbig Ae/Be star V346 Ori is also associated with this grouping, which could be an older analog of σ Ori. Using several sets of evolutionary tracks, we find an age of 7-10 Myr for Ori OB1a and of ~4-6 Myr for Ori OB1b, consistent with previous estimates from OB stars. Indicators such as the equivalent width of Hα and near-IR excesses show that the number of accreting low-mass stars decreases sharply between Ori OB1b and Ori OB1a. These results indicate that although a substantial fraction of accreting disks remain at ages ~5 Myr, inner disks are

Smoking in pregnancy a key factor for sudden infant death among Māori.

PubMed

MacFarlane, M; Mitchell, E A; Thompson, J M D; Lawton, B; Zuccollo, J; Elder, D; Taylor, B; McDonald, G; Stewart, A W; Percival, T; Baker, N; Schlaud, M; Fleming, P

2018-06-05

To examine the Sudden Unexpected Death in Infancy (SUDI) disparity between Māori and non-Māori in New Zealand. A nationwide prospective case-control study ran from March 2012-February 2015. Exposure to established SUDI risk factors was analysed to investigate the disparity experienced by Māori. Infant ethnicity was based on mother's ethnicity. Māori ethnicity was prioritised. Non-Māori includes Pacific, Asian, NZ European and Other. There were 137 cases and 649 controls. The Māori SUDI rate was 1.41/1,000 live births compared to 0.53/1,000 for non-Māori. Parents/caregivers of 133 cases (97%) and 258 controls (40%) were interviewed. Smoking in pregnancy was associated with an equally-increased SUDI risk for Māori (adjusted OR=8.11, 95%CI=2.64, 24.93) and non-Māori (aOR=5.09, 95% CI=1.79, 14.47), as was bed-sharing (aOR=3.66, 95% CI=1.49, 9.00 versus aOR=11.20, 95% CI=3.46, 36.29). Bed-sharing prevalence was similar, however more Māori controls smoked during pregnancy (46.7%) than non-Māori (22.8%). The main contributor relating to increased SUDI risk for Māori/non-Māori infants is the combination of smoking in pregnancy and bed-sharing. The association between known SUDI risk factors, including bed-sharing and/or smoking in pregnancy and SUDI risk, is the same regardless of ethnicity. Māori infants are exposed more frequently to both behaviours because of the higher Māori smoking rate. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Pinnacle of life--Māori living to advanced age.

PubMed

Dyall, Lorna; Kerse, Ngaire; Hayman, Karen; Keeling, Sally

2011-03-25

The purpose of this feasibility study was to investigate whether Māori of advanced age would be interested in and able to take part in a quantitative study involving a comprehensive questionnaire, physical health assessment and blood analyses (a range of biological markers). The study also aimed to involve older Māori in all stages: development of research questions, review of assessment techniques and interpretation of results. Māori aged 75-79 years living in the Bay of Plenty and Lakes DHB areas were invited to participate in a feasibility study covering a wide range of quantitative health related questions. After informed consent interviews and physical assessments were conducted in participants' homes or at a local clinic by Māori health providers contracted as a research partner. For those who gave informed consent specifically for blood analyses, bloods were taken and analysed for defined biological markers of inflammation and ageing. All physical assessments and blood analyses were forwarded to each participant's own general practitioner and relevant guidance was given by the research team. Collective results from 33 Māori participants are presented and cover: Te Reo Māori me ona tikanga (Māori language and cultural knowledge), tribal and whanau (extended family) links, cultural values and religion, whanau engagement and recreational activities, health status, healthy eating and discrimination. The Te Whare Tapa Wha model of health and the Poutama model of human development are utilised to provide an overall framework and context to present the results in respect of our participants and to celebrate their 'advanced' old age. The feasibility study has been successful in engagement with older Māori. It has paved the way to implement a subsequent longitudinal study which aims to enrol 600 Māori aged 80 to 90 years and 600 non-Māori aged 85 years in the Bay of Plenty and Lakes District Health Board areas (Tauranga, Rotorua, Whakatane, Opotiki and Te

Unravelling the whāriki of Crown Māori health infrastructure.

PubMed

Came, Heather; Tudor, Keith

2017-07-07

New Zealand's central government, and more specifically the Ministry of Health, consistently acknowledges their special relationship with Māori and the strategic importance of Māori health, and certainly, strengthening Māori health is critical to addressing systemic health inequities. This paper, framed in terms of the Crown principles attributed to the Treaty of Waitangi, ie, participation, protection and partnership, examines three structural decisions that threaten to unravel the whāriki (foundational mat) of Crown Māori health policy infrastructure. These include the disestablishment of the Ministry of Health's policy team, Te Kete Hauora, revoking mandatory district health boards' (DHB) Māori health plans and reporting, and downscaling the requirements of DHBs to consult. These actions appear to breach the Articles of te Tiriti o Waitangi and may be cited as such in the forthcoming WAI 2575 kaupapa health hearing before the Waitangi Tribunal. The authors call for the Ministry of Health to embrace its Treaty obligations, and to protect and reinstate the whāriki of Māori health infrastructure.

Replication origins oriGNAI3 and oriB of the mammalian AMPD2 locus nested in a region of straight DNA flanked by intrinsically bent DNA sites.

PubMed

Balani, Valério Américo; de Lima Neto, Quirino Alves; Takeda, Karen Izumi; Gimenes, Fabrícia; Fiorini, Adriana; Debatisse, Michelle; Fernandez, Maria Aparecida

2010-11-01

The aim of this work was to determine whether intrinsically bent DNA sites are present at, or close to, the mammalian replication origins oriGNAI3 and oriB in the Chinese hamster AMPD2 locus. Using an electrophoretic mobility shift assay and in silico analysis, we located four intrinsically bent DNA sites (b1 to b4) in a fragment that contains the oriGNAI3 and one site (b5) proximal to oriB. The helical parameters show that each bent DNA site is curved in a left-handed superhelical writhe. A 2D projection of 3D fragment trajectories revealed that oriGNAI3 is located in a relatively straight segment flanked by bent sites b1 and b2, which map in previously identified Scaffold/Matrix Attachment Region. Sites b3 and b4 are located approximately 2 kb downstream and force the fragment into a strong closed loop structure. The b5 site is also located in an S/MAR that is found just downstream of oriB.

Achieving health equity in Aotearoa: strengthening responsiveness to Māori in health research.

PubMed

Reid, Papaarangi; Paine, Sarah-Jane; Curtis, Elana; Jones, Rhys; Anderson, Anneka; Willing, Esther; Harwood, Matire

2017-11-10

Excellent health research is essential for good health outcomes, services and systems. Health research should also build towards equity and in doing so ensure that no one is left behind. As recipients of government funding, researchers are increasingly required to demonstrate an understanding of their delegated responsibilities to undertake research that has the potential to address Māori health needs and priorities. These requirements form the basis of responsiveness to Māori in health research, and several research institutions have implemented systems to support their organisational approach to this endeavour. However, many health researchers have a narrow view of responsiveness to Māori and how it might be relevant to their work. In this viewpoint paper we provide an overview of existing frameworks that can be used to develop thinking and positioning in relation to the Treaty of Waitangi and responsiveness to Māori. We also describe an equity-based approach to responsiveness to Māori and highlight four key areas that require careful consideration, namely: (1) relevance to Māori; (2) Māori as participants; (3) promoting the Māori voice, and; (4) human tissue. Finally, we argue for greater engagement with responsiveness to Māori activities as part of our commitment to achieving equitable health outcomes.

Mortality trends in Australian Aboriginal peoples and New Zealand Māori.

PubMed

Phillips, Bronwen; Daniels, John; Woodward, Alistair; Blakely, Tony; Taylor, Richard; Morrell, Stephen

2017-01-01

The health status of Indigenous populations of Australia and New Zealand (NZ) Māori manifests as life expectancies substantially lower than the total population. Accurate assessment of time trends in mortality and life expectancy allows evaluation of progress in reduction of health inequalities compared to the national or non-Indigenous population. Age-specific mortality and life expectancy (at birth) (LE) for Indigenous populations (Australia from 1990 and NZ from 1950); and all Australia and non-Māori NZ (from 1890), males (M) and females (F), were obtained from published sources and national statistical agency reports. Period trends were assessed for credible estimates of Indigenous LE, and the LE gap compared to the total population for Australia, and non-Māori for NZ. Period trends in premature adult mortality, as cumulative probability of dying over 15-59 years, were assessed similarly. The relative contribution of differences in age-specific mortality to the LE gap between Indigenous and the all-Australia population, and the non-Māori NZ, was estimated for each country by sex for the most recent period: 2010-2012 for Australia, 2012-2014 for NZ. LE increased for all populations, although LE gaps between Indigenous and all Australia showed little change over time. LE gaps between NZ Māori and non-Māori increased significantly from the early 1980s to the mid-1990s, and since then have fallen again. Recent LE gaps in Australia (M 12.5; F 12.0 years in 2010-2012) were larger than in NZ (M 7.3; F 6.8 years in 2012-2014). Premature adult mortality (15-59 years) improved for all populations, but mortality ratios show little change since 2000, with Indigenous at 3½-4 times that of all Australians, and Māori 2-3 times that of non-Māori. Using decomposition analysis, the age interval contributing most strongly to differences in LE between Indigenous and all Australia was 35-59 years, but between Māori and non-Māori it was 60-74 years. In Australia and

The design and relevance of a computerized gamified depression therapy program for indigenous māori adolescents.

PubMed

Shepherd, Matthew; Fleming, Theresa; Lucassen, Mathijs; Stasiak, Karolina; Lambie, Ian; Merry, Sally N

2015-03-03

Depression is a major health issue among Māori indigenous adolescents, yet there has been little investigation into the relevance or effectiveness of psychological treatments for them. Further, consumer views are critical for engagement and adherence to therapy. However, there is little research regarding indigenous communities' opinions about psychological interventions for depression. The objective of this study was to conduct semistructured interviews with Māori (indigenous New Zealand) young people (taitamariki) and their families to find out their opinions of a prototype computerized cognitive behavioral therapy (cCBT) program called Smart, Positive, Active, Realistic, X-factor thoughts (SPARX), a free online computer game intended to help young persons with mild to moderate depression, feeling down, stress or anxiety. The program will teach them how to resolve their issues on their own using Cognitive Behavioural Therapy as psychotherapeutic approach. There were seven focus groups on the subject of the design and cultural relevance of SPARX that were held, with a total of 26 participants (19 taitamarki, 7 parents/caregivers, all Māori). There were five of the groups that were with whānau (family groups) (n=14), one group was with Māori teenage mothers (n=4), and one group was with taitamariki (n=8). The general inductive approach was used to analyze focus group data. SPARX computerized therapy has good face validity and is seen as potentially effective and appealing for Māori people. Cultural relevance was viewed as being important for the engagement of Māori young people with SPARX. Whānau are important for young peoples' well-being. Participants generated ideas for improving SPARX for Māori and for the inclusion of whānau in its delivery. SPARX computerized therapy had good face validity for indigenous young people and families. In general, Māori participants were positive about the SPARX prototype and considered it both appealing and applicable

Strengthening Māori participation in the New Zealand health and disability workforce.

PubMed

Ratima, Mihi M; Brown, Rachel M; Garrett, Nick K G; Wikaire, Erena I; Ngawati, Renei M; Aspin, Clive S; Potaka, Utiku K

2007-05-21

Substantial progress has been made in Māori health and disability workforce development in the past 15 years. Key factors in successful programs to increase Māori health workforce recruitment and retention include Māori leadership, mentorship and peer support; and comprehensive support within study programs and in the transitions between school, university and work. The interventions to date provide a strong basis for ongoing action to address inequities in Māori health workforce participation, and are likely to be relevant to health workforce development approaches for other indigenous peoples.

The Chandra/MOST Campaign on Delta Ori A

NASA Astrophysics Data System (ADS)

Corcoran, Michael

2014-11-01

X-ray emission from massive stars is produced by shocked gas distributed throughout their unstable stellar winds. These shocks play a significant role in determining accurate stellar mass loss rates. Our current understanding of these shocks is derived from indirect indicators like line profile shapes and the f/i ratio of the He-like triplets. Here we discuss a campaign of phase-resolved Chandra grating observations and simultaneous high-precision photometry using the MOST satellite of the massive binary Delta Ori A, in an attempt to directly constrain the radial extent of the hot gas in the wind of the primary star (Delta Ori Aa) via occultation by the X-ray faint secondary (Delta Ori Ab). We present an overview of this campaign and a summary of our results.

Factors associated with nutrition risk in older Māori: a cross sectional study.

PubMed

Wham, Carol; Maxted, Eruera; Teh, Ruth; Kerse, Ngaire

2015-08-21

To investigate factors associated with nutrition risk among older Māori. Māori aged 75-79 years living in the Northland and Bay of Plenty regions of New Zealand were assessed for nutrition risk using the validated screening tool 'Seniors in the Community: Risk Evaluation for Eating and Nutrition' (SCREENII). Demographic, physical and sociocultural data were collected. Of the 67 participants, two thirds (63%) were identified to be at high-risk for malnutrition. More than half (56%) used te reo Māori (Māori language) for everyday conversation and those who rated language and culture as moderately important to wellbeing were at lower nutrition risk. Controlling for age, gender and living arrangements, participants who rated traditional foods as important, were able to access them, had a higher waist-to-hip ratio and an absence of depressive symptoms, were at lower nutrition risk. Cultural factors associated with nutrition risk are related to an indigenous view of health. Participants with a higher waist-to-hip ratio were at lower nutrition risk and this may be a protective factor for older Māori. Interventions to improve the nutrition status of older Māori need to be based on a holistic Māori worldview and acknowledge the importance of traditional Māori foods.

Photometric studies for two contact binaries: V532 Monocerotis and GU Orionis

NASA Astrophysics Data System (ADS)

Yang, Yuangui; Dai, Haifeng; Yuan, Huiyu; Zhang, Xiliang; Zhang, Liyun

2017-08-01

We present photometry and spectroscopy data for V532 Mon and GU Ori, observed in 2011 and 2016. From the spectral observations, the spectral types are determined to be F5V for V532 Mon and G0V for GU Ori. With the 2015-version Wilson-Devinney program, the photometric solutions are simultaneously deduced from VR light curves (LCs). The intrinsic variability for V532 Mon is found by comparing LCs in 2004 and 2011, while the asymmetric LCs for GU Ori are modeled by a cool spot on the more massive component. The results imply that the two stars are A-type contact binaries. The mass ratios and fill-out factors are, respectively, q = 0.190(±0.006) and f = 43.7(±0.9)% for V532 Mon and q = 0.455(±0.020) and f = 26.9(±1.3)% for GU Ori. From the (O - C) curves, it is found that their orbital periods may be undergoing long-term variations. The rates of period change are dP/dt = -1.72(±0.05) × 10-7 d yr-1 for V532 Mon and dP/dt = +1.45(±0.01) × 10-7 d yr-1 for GU Ori. V532 Mon with a decreasing period will evolve into a deep-contact binary, while GU Ori with an increasing period may evolve into a broken-contact case.

Planetary influence in the gap of a protoplanetary disk: structure formation and an application to V1247 Ori

NASA Astrophysics Data System (ADS)

Alvarez-Meraz, R.; Nagel, E.; Rendon, F.; Barragan, O.

2017-10-01

We present a set of hydrodynamical models of a planetary system embedded in a protoplanetary disk in order to extract the number of dust structures formed in the disk, their masses and sizes, within optical depth ranges τ≤0.5, 0.5<τ<2 and τ≥2. The study of the structures shows: (1) an increase in the number of planets implies an increase in the creation rate of massive structures; (2) a lower planetary mass accretion corresponds to slower time effects for optically thin structures; (3) an increase in the number of planets allows a faster evolution of the structures in the Hill radius for the different optical depth ranges of the inner planets. An ad-hoc simulation was run using the available information of the stellar system V1247 Ori, leading to a model of a planetary system which explains the SED and is consistent with interferometric observations of structures.

Development concepts of a Smart Cyber Operating Theater (SCOT) using ORiN technology.

PubMed

Okamoto, Jun; Masamune, Ken; Iseki, Hiroshi; Muragaki, Yoshihiro

2018-02-23

Currently, networking has not progressed in the treatment room. Almost every medical device in the treatment room operates as a stand-alone device. In this project, we aim to develop a networked operating room called "Smart Cyber Operating Theater (SCOT)". Medical devices are connected using Open Resource interface for the Network (ORiN) technology. In this paper, we describe the concept of the SCOT project. SCOT is integrated using the communication interface ORiN, which was originally developed for industry. One feature of ORiN is that the system can be constructed flexibly. ORiN creates abstracts of the same type of devices and increases the robustness of the system for device exchange. By using ORiN technology, we are developing new applications, such as decision-making navigation or a precision guided treatment system.

Predictors of academic success for Māori, Pacific and non-Māori non-Pacific students in health professional education: a quantitative analysis.

PubMed

Wikaire, Erena; Curtis, Elana; Cormack, Donna; Jiang, Yannan; McMillan, Louise; Loto, Rob; Reid, Papaarangi

2017-05-01

Tertiary institutions internationally aim to increase student diversity, however are struggling to achieve equitable academic outcomes for indigenous and ethnic minority students and detailed exploration of factors that impact on success is required. This study explored the predictive effect of admission variables on academic outcomes for health professional students by ethnic grouping. Kaupapa Māori and Pacific research methodologies were used to conduct a quantitative analysis using data for 2686 health professional students [150 Māori, 257 Pacific, 2279, non-Māori non-Pacific (nMnP)]. The predictive effect of admission variables: school decile; attending school in Auckland; type of admission; bridging programme; and first-year bachelor results on academic outcomes: year 2-4 grade point average (GPA); graduating; graduating in the minimum time; and optimal completion for the three ethnic groupings and the full cohort was explored using multiple regression analyses. After adjusting for admission variables, for every point increase in first year bachelor GPA: year 2-4 GPA increased by an average of 0.46 points for Māori (p = 0.0002, 95% CI 0.22, 0.69), 0.70 points for Pacific (p < 0.0001, CI 0.52, 0.87), and 0.55 points for nMnP (p < 0.0001, CI 0.51, 0.58) students. For the total cohort, ethnic grouping was consistently the most significant predictor of academic outcomes. This study demonstrated clear differences in academic outcomes between both Māori and Pacific students when compared to nMnP students. Some (but not all) of the disparities between ethnic groupings could be explained by controlling for admission variables.

Differences in patients' perceptions of Schizophrenia between Māori and New Zealand Europeans.

PubMed

Sanders, Deanna; Kydd, Robert; Morunga, Eva; Broadbent, Elizabeth

2011-06-01

Māori (the Indigenous people of New Zealand) are disproportionately affected by mental illness and experience significantly poorer mental health compared to New Zealand Europeans. It is important to understand cultural differences in patients' ideas about mental illness in treatment settings. The aim of the present study was to investigate differences in illness perceptions between Māori and New Zealand Europeans diagnosed with schizophrenia. A total of 111 users of mental health services (68 Māori, 43 New Zealand European) in the greater Auckland and Northland areas who had been diagnosed with schizophrenia or other psychotic disorder were interviewed using the Brief Illness Perception Questionnaire and the Drug Attitude Inventory. District Health Board staff completed the Global Assessment of Functioning for each patient. Māori with schizophrenia believed that their illness would continue significantly less time than New Zealand European patients did. Chance or spiritual factors were listed as causes of mental illness by only five Māori patients and no New Zealand European patients. Other illness perceptions, as well as attitudes towards medication, were comparable between groups. Across groups, the top perceived causes were drugs/alcohol, family relationships/abuse, and biological causes. Illness perceptions provide a framework to assess patients' beliefs about their mental illness. Differences between Māori and New Zealand European patients' beliefs about their mental illness may be related to traditional Māori beliefs about mental illness. Knowledge of differences in illness perceptions provides an opportunity to design effective clinical interventions for both Māori and New Zealand Europeans.

OriDB, the DNA replication origin database updated and extended.

PubMed

Siow, Cheuk C; Nieduszynska, Sian R; Müller, Carolin A; Nieduszynski, Conrad A

2012-01-01

OriDB (http://www.oridb.org/) is a database containing collated genome-wide mapping studies of confirmed and predicted replication origin sites. The original database collated and curated Saccharomyces cerevisiae origin mapping studies. Here, we report that the OriDB database and web site have been revamped to improve user accessibility to curated data sets, to greatly increase the number of curated origin mapping studies, and to include the collation of replication origin sites in the fission yeast Schizosaccharomyces pombe. The revised database structure underlies these improvements and will facilitate further expansion in the future. The updated OriDB for S. cerevisiae is available at http://cerevisiae.oridb.org/ and for S. pombe at http://pombe.oridb.org/.

Chromosomal insertions localized around oriC affect the cell cycle in Escherichia coli.

PubMed

Molina, F; Jiménez-Sánchez, A; Zyskind, J W; Guzmán, E C

1999-01-01

The present work reports the effects of localized insertions around the origin of Escherichia coli chromosome, oriC, on cell cycle parameters. These insertions cause an increase of the C period with an inverse correlation to the distance from oriC. In addition, Omega insertion near oriC causes an increase in the number of replication forks per chromosome, n, and Tn10 insertion causes a decrease in growth rate. We found that the same insertion positioned in another region of the chromosome, outside of oriC, has a negligible effect on the C period. Marker frequency analysis suggests a slower replication velocity along the whole chromosome. We propose that the insertions positioned at less than 2 kbp from oriC could create a structural alteration in the origin of replication that would result in a longer C period. Flow cytometry reveals that asynchrony is not associated with these alterations.

Rehabilitation and indigenous peoples: the Māori experience.

PubMed

Harwood, Matire

2010-01-01

Indigenous peoples often have the worst health status in comparison to non-indigenous people in their own nations; urgent action to address the health inequities for indigenous people is required. The role of rehabilitation in addressing health and disability inequities is particularly important due to the health need of indigenous peoples; the unequal distribution of health determinants; and disparities in access to, quality of care through and outcomes following rehabilitation. This article will present a perspective for Māori, the indigenous peoples of New Zealand, on a framework for improving rehabilitation services for Māori and ultimately their health and wellbeing.

Wāhine hauora: linking local hospital and national health information datasets to explore maternal risk factors and obstetric outcomes of New Zealand Māori and non-Māori women in relation to infant respiratory admissions and timely immunisations.

PubMed

Filoche, Sara; Garrett, Susan; Stanley, James; Rose, Sally; Robson, Bridget; Elley, C Raina; Lawton, Bev

2013-07-10

Significant health inequities exist around maternal and infant health for Māori, the indigenous people of New Zealand. The infants of Māori are more likely to die in their first year of life and also have higher rates of hospital admission for respiratory illnesses, with the greatest burden of morbidity being due to bronchiolitis in those under one year of age. Timely immunisations can prevent some respiratory related hospitalisations, although for Māori, the proportion of infants with age appropriate immunisations are lower than for non-Māori. This paper describes the protocol for a retrospective cohort study that linked local hospital and national health information datasets to explore maternal risk factors and obstetric outcomes in relation to respiratory admissions and timely immunisations for infants of Māori and non-Māori women. The study population included pregnant women who gave birth in hospital in one region of New Zealand between 1995 and 2009. Routinely collected local hospital data were linked via a unique identifier (National Health Index number) to national health information databases to assess rates of post-natal admissions and access to health services for Māori and non-Māori mothers and infants. The two primary outcomes for the study are: 1. The rates of respiratory hospitalisations of infants (≤ 1 yr of age) calculated for infants of both Māori and non-Māori women (for mothers under 20 years of age, and overall) accounting for relationship to parity, maternal age, socioeconomic deprivation index, maternal smoking status. 2. The proportion of infants with age appropriate immunisations at six and 12 months, calculated for both infants born to Māori women and infants born to non-Māori women, accounting for relationship to parity, maternal age, socioeconomic deprivation index, smoking status, and other risk factors. Analysis of a wide range of routinely collected health information in which maternal and infant data are linked will

Dependence on place: A source of autonomy in later life for older Māori.

PubMed

Butcher, Elizabeth; Breheny, Mary

2016-04-01

Attachment to place is an important component of ageing. Although the importance of place for older people's well-being is known, the ways in which different conceptions of place and expectations for what later life may hold depend upon cultural beliefs, values, and expectations is underexplored. This study examined the ways that place influences experiences of ageing for older Māori in New Zealand. Eight interviews with older Māori were analysed thematically alongside field notes from a research visit. Attachment to place provided the foundation for experiences of ageing for older Māori. Through their connection to place, the participants drew on a comforting and comfortable dependence on land and family to enable autonomy in later life. Rather than seeking to maintain independence in terms of avoiding reliance on others, older Māori conceptualised older age through autonomy and freedom to live in accordance with Māori values encapsulated by whakawhanaungatanga. A good old age depended on balancing competing demands of living in wider society with attachment to place and Māori identity in later life. Copyright © 2016 Elsevier Inc. All rights reserved.

Looking Māori Predicts Decreased Rates of Home Ownership: Institutional Racism in Housing Based on Perceived Appearance

PubMed Central

2015-01-01

This study examined differences in rates of home ownership among Māori (the indigenous peoples of New Zealand). We identified systematic factors that predicted why some Māori were more likely to own their own home (partially or fully) relative to other Māori. Data were drawn from a large national postal sample of 561 self-identified Māori collected as part of the New Zealand Attitudes and Values Study. As predicted, our analyses indicated that self-reported appearance as Māori, or the extent to which people thought they personally displayed features which visibly identified them as Māori to others, significantly predicted decreased rates of home ownership. This association held when adjusting for numerous demographic covariates, such as education, level of deprivation of the immediate area, household income, age, relationship status, region of residence, and so forth. Our analyses suggest there is, or at least has been in the recent past, institutional racism against Māori in New Zealand’s home lending industry based on merely appearing more Māori. PMID:25738961

Looking Māori predicts decreased rates of home ownership: institutional racism in housing based on perceived appearance.

PubMed

Houkamau, Carla A; Sibley, Chris G

2015-01-01

This study examined differences in rates of home ownership among Māori (the indigenous peoples of New Zealand). We identified systematic factors that predicted why some Māori were more likely to own their own home (partially or fully) relative to other Māori. Data were drawn from a large national postal sample of 561 self-identified Māori collected as part of the New Zealand Attitudes and Values Study. As predicted, our analyses indicated that self-reported appearance as Māori, or the extent to which people thought they personally displayed features which visibly identified them as Māori to others, significantly predicted decreased rates of home ownership. This association held when adjusting for numerous demographic covariates, such as education, level of deprivation of the immediate area, household income, age, relationship status, region of residence, and so forth. Our analyses suggest there is, or at least has been in the recent past, institutional racism against Māori in New Zealand's home lending industry based on merely appearing more Māori.

The prevalence of symptoms of depression and anxiety, and the level of life stress and worry in New Zealand Māori and non-Māori women in late pregnancy.

PubMed

Signal, T Leigh; Paine, Sarah-Jane; Sweeney, Bronwyn; Muller, Diane; Priston, Monique; Lee, Kathryn; Gander, Philippa; Huthwaite, Mark

2017-02-01

To describe the prevalence of symptoms of depression and anxiety, and the level of life stress and worry in late pregnancy for Māori and non-Māori women. In late pregnancy, women completed a questionnaire recording their prior history of mood disorders; self-reported current depressive symptoms (⩾13 on the Edinburgh Postnatal Depression Scale), current anxiety symptoms (⩾6 on the anxiety items from the Edinburgh Postnatal Depression Scale), significant life stress (⩾2 items on life stress scale) and dysfunctional worry (>12 on the Brief Measure of Worry Scale). Data were obtained from 406 Māori women (mean age = 27.6 years, standard deviation=6.3 years) and 738 non-Māori women (mean age = 31.6 years, standard deviation=5.3 years). Depressive symptoms (22% vs 15%), anxiety symptoms (25% vs 20%), significant life stress (55% vs 30%) and a period of poor mood during the current pregnancy (18% vs 14%) were more prevalent for Māori than non-Maori women. Less than 50% of women who had experienced ⩾2 weeks of poor mood during the current pregnancy had sought help. Being young was an independent risk factor for depressive symptoms, significant life stress and dysfunctional worry. A prior history of depression was also consistently associated with a greater risk of negative affect in pregnancy. Antenatal mental health requires at least as much attention and resourcing as mental health in the postpartum period. Services need to specifically target Māori women, young women and women with a prior history of depression.

Effect of Lactobacillus johnsonii CRL1647 on different parameters of honeybee colonies and bacterial populations of the bee gut.

PubMed

Audisio, M C; Sabaté, D C; Benítez-Ahrendts, M R

2015-01-01

Lactobacillus johnsonii CRL1647, isolated from the intestinal tract of a worker-bee in Salta, Argentina, was delivered to Apis mellifera L. honey bee colonies according to two different administration schedules: 1×10(5) cfu/ml every 15 days (2011) or monthly (2012). The effect of each treatment on the bee-colony performance was monitored by measuring honey production, and the prevalence of varroasis and nosemosis. Worker bees from each assay were randomly captured 3 days after administration and assayed for the following intestinal culturable and defined bacterial populations: total aerobic microorganisms, Bacillus spp. spores, Lactobacillus spp., Enterococcus spp. and enterobacteria. Interestingly, both treatments generated a similar increase in honey production in treated colonies compared to controls: 36.8% (every 15 days) and 36.3% (monthly). Nosema index always exhibited a reduction when lactobacilli were administered; in turn, Varroa incidence was lower when the lactobacilli were administered once a month. Moreover, the administration of L. johnsonii CRL1647 every 15 days produced an increase in the total number of aerobic microorganisms and in bacteria belonging to the genera Lactobacillus and Enterococcus; at the same time, a decrease was observed in the number of total spores at the end of the treatment. The number of enterobacteria was constant and remained below that of control hives at the end of the assay. On the other hand, the delivery of lactobacilli once a month only showed an increase in the number of bacteria belonging to the genus Lactobacillus; meanwhile, viable counts of the remaining microorganisms assayed were reduced. Even though it seems that both treatments were similar, those bee colonies that received L. johnsonii CRL1647 every 15 days became so strong that they swarmed.

Narratives of four Māori ex-inmates about their experiences and perspectives of rehabilitation programmes.

PubMed

Nakhid, Camille; Shorter, Lily Tairiri

2014-06-01

Māori are overrepresented in the criminal justice system in Aotearoa New Zealand. Māori offenders comprise 53% of those serving custodial sentences and 48% serving community-based sentences. The majority of Māori offenders reoffended within 2 years of serving their sentence. A number of programmes aimed at reducing recidivism among Māori have been implemented, and there is considerable debate around the effectiveness of these programmes. This qualitative study focuses on the narratives of four Māori male ex-inmates about their reoffending and their experiences of the rehabilitation programmes during their incarceration. Using a narrative approach, the study sought to hear the shared stories from the men and to determine what they believe would have reduced their reoffending. The stories revealed that a lack of financial resources and gang connections influenced reoffending; the value of prison rehabilitation programmes varied depending on their appropriateness to the inmate and to their intended outcomes; and healing programmes incorporating kaupapa Māori principles and practices assisted the participants in understanding their cultural heritage and communicating with society in more acceptable ways.

Applying Community-Based Participatory Research to Create a Diabetes Prevention Documentary with New Zealand Māori.

PubMed

Farmer, Alison; Gage, Jeffrey; Kirk, Ray; Edgar, Timothy

2016-01-01

Type 2 diabetes is almost three times more prevalent in the indigenous people of New Zealand (Māori) than non-Māori. Despite the high rate of diabetes in the Māori population, little is known about their personal understanding or experience of the disease. To engage Māori in a participatory process to develop a culturally relevant diabetes prevention documentary. Principles of community-based participatory research (CBPR) were applied to a qualitative research design employing key informant interviews and focus groups to develop a diabetes prevention documentary. A CBPR approach provides an appropriate model for enacting local action-oriented approaches in the creation of a documentary that reflects Māori cultural beliefs and practices.

Insanity and ethnicity in New Zealand: Māori encounters with the Auckland Mental Hospital, 1860-1900.

PubMed

Barry, Lorelle; Coleborne, Catharine

2011-09-01

This article examines Māori patients at the Auckland Mental Hospital between 1860 and 1900.We argue that the patient case notes reveal 'European' categories in which Māori were situated, and demonstrate the extent to which the authorities at the hospital grappled with their appearance, their language and their culture, all of which were elements of their ethnicity. We argue that the use of institutional case records is highly suggestive of some of the historical meanings of insanity for Māori, including the lack of detailed or sustained collection of information about patients' tribal affiliations, the interest shown in their rights to land in maintenance payment inquiries, the experiences of cultural alienation or mate Māori, and the sad outcomes for Māori.

The Minimal Replicator of Epstein-Barr Virus oriP

PubMed Central

Yates, John L.; Camiolo, Sarah M.; Bashaw, Jacqueline M.

2000-01-01

oriP is a 1.7-kb region of the Epstein-Barr virus (EBV) chromosome that supports the replication and stable maintenance of plasmids in human cells. oriP contains two essential components, called the DS and the FR, both of which contain multiple binding sites for the EBV-encoded protein, EBNA-1. The DS appears to function as the replicator of oriP, while the FR acts in conjunction with EBNA-1 to prevent the loss of plasmids from proliferating cells. Because of EBNA-1's role in stabilizing plasmids through the FR, it has not been entirely clear to what extent EBNA-1 might be required for replication from oriP per se, and a recent study has questioned whether EBNA-1 has any direct role in replication. In the present study we found that plasmids carrying oriP required EBNA-1 to replicate efficiently even when assayed only 2 days after plasmids were introduced into the cell lines 143B and 293. Significantly, using 293 cells it was demonstrated that the plasmid-retention function of EBNA-1 and the FR did not contribute significantly to the accumulation of replicated plasmids, and the DS supported efficient EBNA-1-dependent replication in the absence of the FR. The DS contains two pairs of closely spaced EBNA-1 binding sites, and a previous study had shown that both sites within either pair are required for activity. However, it was unclear from previous work what additional sequences within the DS might be required. We found that each “half” of the DS, including a pair of closely spaced EBNA-1 binding sites, had significant replicator activity when the other half had been deleted. The only significant DNA sequences that the two halves of the DS share in common, other than EBNA-1 binding sites, is a 9-bp sequence that is present twice in the “left half” and once in the “right half.” These nonamer repeats, while not essential for activity, contributed significantly to the activity of each half of the DS. Two thymines occur at unique positions within EBNA-1

A qualitative Kaupapa Māori approach to understanding infant and young child feeding practices of Māori and Pacific grandparents in Auckland, New Zealand.

PubMed

Tapera, Rachel; Harwood, Matire; Anderson, Anneka

2017-04-01

The present research sought to better understand the barriers, facilitators, attitudes and beliefs that influence the way Māori and Samoan grandparents feed their grandchildren in a deprived urban neighbourhood in New Zealand. The research adopted a qualitative methodology that was consistent with a Kaupapa Māori research approach. Seven semi-structured interviews were conducted with grandparents to collect narrative data. Sampling occurred in one Auckland suburb. The suburb was selected because of its high level of socio-economic deprivation and ethnic diversity. Seven grandparents participated in the study (five Māori and two Samoan). Each participant met the inclusion criteria (i.e. they had provided at least five meals per week over the previous three months to grandchildren aged less than 24 months). Marae (i.e. meeting houses and areas used by local Māori tribes/sub-tribes) and community organisations were used to recruit participants. A general inductive thematic analysis identified four key themes: (i) grandparents' understanding of optimal feeding practices; (ii) economic and material factors; (iii) previous experiences and customary norms; and (iv) social support and societal pressure. The study showed that grandparents' complementary feeding practices in caring for infant grandchildren were influenced by upstream structural elements such as government policies related to welfare and pensions, employment, income and cultural knowledge. Frameworks that seek to achieve social justice and support cultural practices should be employed and promoted in the development of future policy and research in this area.

Volunteering predicts happiness among older Māori and non-Māori in the New Zealand health, work, and retirement longitudinal study.

PubMed

Dulin, Patrick L; Gavala, Jhanitra; Stephens, Christine; Kostick, Marylynne; McDonald, Jennifer

2012-01-01

This study sought to understand the relationship between volunteer activity and happiness among a sample of older adult New Zealanders. It specifically sought to determine if ethnicity (Māori vs. non-Māori) and economic living standards (ELS) functioned as moderators of the relationship between volunteering and happiness. Data were garnered from the 2008 administration of the New Zealand Health, Work, and Retirement Longitudinal Study. Correlational and multiple regression procedures were employed to examine study hypotheses. Results from multiple regression analyses showed that the amount of volunteering per week was a unique predictor of the overall level of happiness. Moderation analyses indicated that ethnicity did not function as a moderator of the relationship between volunteering and happiness, but ELS did. Those with low ELS evidenced a stronger relationship between volunteering and happiness than those with high ELS. Results also indicated that Maori and those with low ELS volunteered more frequently than non-Māori and those with high ELS. This study provides evidence that volunteering is related to increased happiness, irrespective of ethnicity. It also provides further evidence that the relationship between volunteering and happiness is moderated by economic resources. Older individuals at the low end of the economic spectrum are likely to benefit more from volunteering than those at the high end.

Orbital Solution for the Spectroscopic Binary in the GW Ori Hierarchical Triple

NASA Astrophysics Data System (ADS)

Prato, L.; Ruíz-Rodríguez, Dary; Wasserman, L. H.

2018-01-01

We present the first double-lined orbital solution for the close binary in the GW Ori triple system. Using 12 epochs of infrared spectroscopy, we detected the lines of both stars in the inner pair, previously known as single-lined only. Our preliminary infrared orbital solution has an eccentricity of e = 0.21 ± 0.10, a period of P = 241.15 ± 0.72 days, and a mass ratio of q = 0.66 ± 0.13. We find a larger semi-amplitude for the primary star, K1 = 6.57 ± 1.00 km s‑1, with an infrared-only solution compared to K1 = 4.41 ± 0.33 km s‑1 with optical data from the literature, likely the result of line blending and veiling in the optical. The component spectral types correspond to G3 and K0 stars, with v\\sin i values of 43 km s‑1 and 50 km s‑1, respectively. We obtained a flux ratio of α = 0.58 ± 0.14 in the H-band, allowing us to estimate individual masses of 3.2 and 2.7 M ⊙ for the primary and secondary, respectively, using evolutionary tracks. The tracks also yield a coeval age of 1 Myr for both components to within 1σ. GW Ori is surrounded by a circumbinary/circumtriple disk. A tertiary component has been detected in previous studies; however, we did not detect this component in our near-infrared spectra, probably the result of its relative faintness and blending in the absorption lines of these rapidly rotating stars. With these results, GW Ori joins the small number of classical T Tauri, double-lined spectroscopic binaries.

The effectiveness of television advertising campaigns on generating calls to a national Quitline by Māori.

PubMed

Wilson, N; Grigg, M; Graham, L; Cameron, G

2005-08-01

To examine the effectiveness of four mass media campaigns on calls to a national Quitline by Māori (the indigenous people of New Zealand). Monthly Quitline call data and calls within one hour of a television commercial (TVC) being shown were analysed for the 2002-2003 period. Data on target audience rating points (TARPs) and expenditure on TVCs were also used (n = 2319 TVC placements). Māori were found to register with the Quitline at higher rates during the most intense six campaign months (15% more registrations compared to less intense months). The most effective campaign generated 115 calls per 100 TARPs by Māori callers within one hour of TVC airing (the "Every cigarette" campaign). A more Māori orientated campaign with both health and cultural themes generated 91 calls per 100 TARPs from Māori callers. For these two campaigns combined, the advertising cost per new registration with the Quitline by a Māori caller was NZD 30-48. Two second hand smoke campaigns that did not show the Quitline number were much less effective at 25 and 45 calls per 100 TARPs. These television advertising campaigns were effective and cost effective in generating calls to a national Quitline by Māori. Health authorities should continue to explore the use of both "threat appeal" style media campaigns and culturally appropriate campaigns to support Quitline use by indigenous peoples.

Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets.

PubMed

Hollis-Moffatt, Jade E; Xu, Xin; Dalbeth, Nicola; Merriman, Marilyn E; Topless, Ruth; Waddell, Chloe; Gow, Peter J; Harrison, Andrew A; Highton, John; Jones, Peter B B; Stamp, Lisa K; Merriman, Tony R

2009-11-01

To examine the role of genetic variation in the renal urate transporter SLC2A9 in gout in New Zealand sample sets of Māori, Pacific Island, and Caucasian ancestry and to determine if the Māori and Pacific Island samples could be useful for fine-mapping. Patients (n= 56 Māori, 69 Pacific Island, and 131 Caucasian) were recruited from rheumatology outpatient clinics and satisfied the American College of Rheumatology criteria for gout. The control samples comprised 125 Māori subjects, 41 Pacific Island subjects, and 568 Caucasian subjects without arthritis. SLC2A9 single-nucleotide polymorphisms rs16890979 (V253I), rs5028843, rs11942223, and rs12510549 were genotyped (possible etiologic variants in Caucasians). Association of the major allele of rs16890979, rs11942223, and rs5028843 with gout was observed in all sample sets (P = 3.7 x 10(-7), 1.6 x 10(-6), and 7.6 x 10(-5) for rs11942223 in the Māori, Pacific Island, and Caucasian samples, respectively). One 4-marker haplotype (1/1/2/1; more prevalent in the Māori and Pacific Island control samples) was not observed in a single gout case. Our data confirm a role of SLC2A9 in gout susceptibility in a New Zealand Caucasian sample set, with the effect on risk (odds ratio >2.0) greater than previous estimates. We also demonstrate association of SLC2A9 with gout in samples of Māori and Pacific Island ancestry and a consistent pattern of haplotype association. The presence of both alleles of rs16890979 on susceptibility and protective haplotypes in the Māori and Pacific Island sample is evidence against a role for this nonsynonymous variant as the sole etiologic agent. More extensive linkage disequilibrium in Māori and Pacific Island samples suggests that Caucasian samples may be more useful for fine-mapping.

Understanding the role of culture in pain: Māori practitioner perspectives of pain descriptors.

PubMed

Magnusson, Jane E; Fennell, Joyce A

2011-01-21

There is growing interest in the role of cultural diversity within healthcare settings yet minority ethnic groups are underrepresented in the healthcare literature, including the literature on pain. To better assess and treat pain in different cultures the perspectives and experiences of that culture must be taken into consideration and therefore the present study was undertaken to better understand Māori perspectives of pain. Māori healthcare providers and kaumātua (tribal leaders/elders) completed questionnaires relating to the experience of pain and were asked to provide feedback regarding the suitability of words and phrases typically used to describe symptoms of pain and pain-related disability. Participants were also asked to provide words, or phrases (in te reo Māori or English) representing characteristics of pain which had not been provided but would be useful in the assessment of pain in a Māori population. All of the pain descriptors, and 92% of the phrases regarding the experience of pain, provided were endorsed by the majority of participants demonstrating that, as in many cultures, Māori perceive pain as a multidimensional experience impacting them on physiological, psychological, and social dimensions and that the terms and phrases of measures commonly used to assess pain appropriately capture their pain experiences. The implications of these findings are that established measures can be used when assessing pain in Māori. However, it is beneficial to confirm that the descriptors used in those measures accurately capture the experiences being measured.

Cultural health literacy: the experiences of Māori in palliative care.

PubMed

Kidd, Jacquie; Black, Stella; Blundell, Rawiri; Peni, Tamati

2018-05-01

Health literacy is a concept that is frequently applied to the patient's ability to find and comprehend health information. However, recent literature has included the skill of the health professional and the accessibility of health resources as important factors in the level of health literacy achieved by individuals and populations. In 2014 a qualitative study undertaken in Aotearoa New Zealand, investigated the context of health literacy for Māori in a palliative care setting (Māori are the indigenous people of Aotearoa New Zealand). The study included the experiences of patients, whānau (families), and health professionals. Individual semi-structured interviews were held with 21 patients, whānau and six key informants: a medical specialist, a service leader involved in developing culturally specific responses to patients, two Māori service managers, and two Māori health team leaders. Focus groups were held with a total of 54 health professionals providing palliative care services. A thematic analysis was undertaken using a general inductive approach. The trustworthiness and reliability of the analysis was supported by sharing analysis of the transcripts among the research team. Member checking or respondent validation was used in seeking confirmation of the interim findings at five hui (meetings) with the research communities involved. This study found that the shock and grief that attends a life-limiting illness made hearing and processing health information very difficult for patients and whānau. Further, 'hard conversations' about moving from active treatment to palliative care were often avoided by health professionals, leaving patients and whānau distressed and confused about their choices and prognosis. Finally, poor cultural health literacy on the part of organisations has likely impacted on late access to or avoidance of palliative care for Māori.

42 CFR 93.402 - ORI allegation assessments.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false ORI allegation assessments. 93.402 Section 93.402 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

oriTfinder: a web-based tool for the identification of origin of transfers in DNA sequences of bacterial mobile genetic elements.

PubMed

Li, Xiaobin; Xie, Yingzhou; Liu, Meng; Tai, Cui; Sun, Jingyong; Deng, Zixin; Ou, Hong-Yu

2018-05-04

oriTfinder is a web server that facilitates the rapid identification of the origin of transfer site (oriT) of a conjugative plasmid or chromosome-borne integrative and conjugative element. The utilized back-end database oriTDB was built upon more than one thousand known oriT regions of bacterial mobile genetic elements (MGEs) as well as the known MGE-encoding relaxases and type IV coupling proteins (T4CP). With a combination of similarity searches for the oriTDB-archived oriT nucleotide sequences and the co-localization of the flanking relaxase homologous genes, the oriTfinder can predict the oriT region with high accuracy in the DNA sequence of a bacterial plasmid or chromosome in minutes. The server also detects the other transfer-related modules, including the potential relaxase gene, T4CP gene and the type IV secretion system gene cluster, and the putative genes coding for virulence factors and acquired antibiotic resistance determinants. oriTfinder may contribute to meeting the increasing demands of re-annotations for bacterial conjugative, mobilizable or non-transferable elements and aid in the rapid risk accession of disease-relevant trait dissemination in pathogenic bacteria of interest. oriTfinder is freely available to all users without any login requirement at http://bioinfo-mml.sjtu.edu.cn/oriTfinder.

Indigenous Māori perspectives on urban transport patterns linked to health and wellbeing.

PubMed

Raerino Ngāti Awa Te Arawa, K; Macmillan, Alex K; Jones Ngāti Kahungunu, Rhys G

2013-09-01

There is a growing body of research linking urban transport systems to inequities in health. However, there is a lack of research providing evidence of the effect of transport systems on indigenous family wellbeing. We examined the connections between urban transport and the health and wellbeing of Māori, the indigenous people of New Zealand. We provide an indigenous exploration of current urban transport systems, with a particular focus on the impacts of car dependence and the need for culturally relevant travel. We interviewed nineteen Māori participants utilising qualitative research techniques underpinned by an indigenous research methodology (Kaupapa Māori). The data highlighted the importance of accessing cultural activities and sites relevant to 'being Māori', and issues with affordability and safety of public transport. Understanding the relationship between indigenous wellbeing and transport systems that goes further than limited discourses of inequity is essential to improving transport for indigenous wellbeing. Providing an indigenous voice in transport decision-making will make it more likely that indigenous health and wellbeing is prioritised in transport planning. Copyright © 2013. Published by Elsevier Ltd.

The effectiveness of television advertising campaigns on generating calls to a national Quitline by Māori

PubMed Central

Wilson, N; Grigg, M; Graham, L; Cameron, G

2005-01-01

Methods: Monthly Quitline call data and calls within one hour of a television commercial (TVC) being shown were analysed for the 2002–2003 period. Data on target audience rating points (TARPs) and expenditure on TVCs were also used (n = 2319 TVC placements). Results: Māori were found to register with the Quitline at higher rates during the most intense six campaign months (15% more registrations compared to less intense months). The most effective campaign generated 115 calls per 100 TARPs by Māori callers within one hour of TVC airing (the "Every cigarette" campaign). A more Māori orientated campaign with both health and cultural themes generated 91 calls per 100 TARPs from Māori callers. For these two campaigns combined, the advertising cost per new registration with the Quitline by a Māori caller was $NZ30–48. Two second hand smoke campaigns that did not show the Quitline number were much less effective at 25 and 45 calls per 100 TARPs. Conclusions: These television advertising campaigns were effective and cost effective in generating calls to a national Quitline by Māori. Health authorities should continue to explore the use of both "threat appeal" style media campaigns and culturally appropriate campaigns to support Quitline use by indigenous peoples. PMID:16046693

Prevalence of mental disorders among Māori in Te Rau Hinengaro: the New Zealand Mental Health Survey.

PubMed

Baxter, Joanne; Kingi, Te Kani; Tapsell, Rees; Durie, Mason; McGee, Magnus A

2006-10-01

To describe the prevalence of mental disorders (period prevalence across aggregated disorders, 12 month and lifetime prevalence) among Māori in Te Rau Hinengaro: The New Zealand Mental Health Survey. Te Rau Hinengaro: The New Zealand Mental Health Survey, undertaken between 2003 and 2004, was a nationally representative face-to-face household survey of 12,992 New Zealand adults aged 16 years and over, including 2,595 Māori. Ethnicity was measured using the 2001 New Zealand census ethnicity question. A fully structured diagnostic interview, the World Health Organization World Mental Health Survey Initiative version of the Composite International Diagnostic Interview (CIDI 3.0), was used to measure disorder. The overall response rate was 73.3%. This paper presents selected findings for the level and pattern of mental disorder prevalence among Māori. Māori lifetime prevalence of any disorder was 50.7%, 12 month prevalence 29.5% and 1 month prevalence 18.3%. The most common 12 month disorders were anxiety (19.4%), mood (11.4%) and substance (8.6%) disorders and the most common lifetime disorders were anxiety (31.3%), substance (26.5%) and mood (24.3%) disorders. Levels of lifetime comorbidity were high with 12 month prevalence showing 16.4% of Māori with one disorder, 7.6% with two disorders and 5.5% with three or more disorders. Twelve-month disorders were more common in Māori females than in males (33.6%vs 24.8%) and in younger age groups: 16-24 years, 33.2%; 25-44 years, 32.9%; 45-64 years, 23.7%; and 65 years and over, 7.9%. Disorder prevalence was greatest among Māori with the lowest equivalized household income and least education. However, differences by urbanicity and region were not significant. Of Māori with any 12 month disorder, 29.6% had serious, 42.6% had moderate and 27.8% had mild disorders. Mental disorders overall and specific disorder groups (anxiety, mood and substance) are common among Māori and measures of severity indicate that disorders

Pathways to ambulatory sensitive hospitalisations for Māori in the Auckland and Waitemata regions.

PubMed

Barker, Carol; Crengle, Sue; Bramley, Dale; Bartholomew, Karen; Bolton, Patricia; Walsh, Michael; Wignall, Jean

2016-10-28

Ambulatory Sensitive Hospitalisations (ASH) are a group of conditions potentially preventable through interventions delivered in the primary health care setting. ASH rates are consistently higher for Māori compared with non-Māori. This study aimed to establish Māori experience of factors driving the use of hospital services for ASH conditions, including barriers to accessing primary care. A telephone questionnaire exploring pathways to ASH was administered to Māori (n=150) admitted to Auckland and Waitemata District Health Board (DHB) hospitals with an ASH condition between January 1st-June 30th 2015. A cohort of 1,013 participants were identified; 842 (83.1%) were unable to be contacted. Of the 171 people contactable, 150 agreed to participate, giving an overall response rate of 14.8% and response rate of contactable patients of 87.7%. Results demonstrated high rates of self-reported enrolment, utilisation and preference for primary care. Many participants demonstrated appropriate health seeking behaviour and accurate recall of diagnoses. While financial barriers to accessing primary care were reported, non-financial barriers including lack of after-hours provision (12.6% adults, 37.7% children), appointment availability (7.4% adults, 17.0% children) and lack of transport (13.7% adults, 20.8% children) also featured in participant responses. Interventions to reduce Māori ASH include: timely access to primary care through electronic communications, increased appointment availability, extended opening hours, low cost after-hours care and consistent best management of ASH conditions in general practice through clinical pathways. Facilitated enrolment of ASH patients with no general practitioner could also reduce ASH. Research into transport barriers and enablers for Māori accessing primary care is required to support future interventions.

Versatility of the Angularis Oris Axial Pattern Flap for Facial Reconstruction.

PubMed

Losinski, Sara L; Stanley, Bryden J; Schallberger, Sandra P; Nelson, Laura L; Towle Millard, Heather A M

2015-11-01

To describe the versatility of the axial pattern flap based on the cutaneous perforating branch of the angularis oris artery for reconstruction of large facial defects in dogs, including complications and clinical outcomes. Retrospective clinical case series. Client-owned dogs (n = 8). Facial flaps (n = 9) based at the commissure of the lip with a caudodorsal orientation were utilized, with established anatomical borders. Flaps were elevated deep to the panniculus carnosus in a caudal to rostral direction, preserving the angularis oris artery, its cutaneous perforator, and surrounding cutaneous vasculature. Flaps were rotated dorsally or ventrally to cover the defect. Primary closure of the donor site was by direct apposition in all cases. Angularis oris axial pattern flaps were most commonly used to close large defects of the nasomaxillary area rostral to the eyes (6 dogs), followed by orbital (2) and intermandibular (1) defects. Defects occurred because of tumor resection (6 dogs), trauma (2), and a chronic, non-healing wounding (1). All flaps healed with acceptable functional and cosmetic outcomes without major complications. Followup ranged from 10 days to 16 months. Minor postoperative complications included flap edema (8 dogs), partial incisional dehiscence (3), distal tip necrosis (2), and oroantral fistula recurrence (1). Angularis oris axial pattern flaps provided hirsute, full-thickness skin coverage of a variety of large facial defects with minor complications, and should be considered when restructuring large defects of the rostral face or chin. © Copyright 2015 by The American College of Veterinary Surgeons.

Toward an Objective Enhanced-V Detection Algorithm

NASA Technical Reports Server (NTRS)

Brunner, Jason; Feltz, Wayne; Moses, John; Rabin, Robert; Ackerman, Steven

2007-01-01

The area of coldest cloud tops above thunderstorms sometimes has a distinct V or U shape. This pattern, often referred to as an "enhanced-V' signature, has been observed to occur during and preceding severe weather in previous studies. This study describes an algorithmic approach to objectively detect enhanced-V features with observations from the Geostationary Operational Environmental Satellite and Low Earth Orbit data. The methodology consists of cross correlation statistics of pixels and thresholds of enhanced-V quantitative parameters. The effectiveness of the enhanced-V detection method will be examined using Geostationary Operational Environmental Satellite, MODerate-resolution Imaging Spectroradiometer, and Advanced Very High Resolution Radiometer image data from case studies in the 2003-2006 seasons. The main goal of this study is to develop an objective enhanced-V detection algorithm for future implementation into operations with future sensors, such as GOES-R.

Dietary intakes of Pacific, Māori, Asian and European adolescents: the Auckland High School Heart Survey.

PubMed

Sluyter, John D; Schaaf, David; Metcalf, Patricia A; Scragg, Robert K R

2010-02-01

To compare dietary intakes of European, Māori, Pacific Island and Asian adolescents living in Auckland. A self-administered food frequency questionnaire was used to assess daily nutrient intakes of 2,549 14- to 21-year-old high-school students in Auckland (1,422 male and 1,127 female) in a cross-sectional survey carried out between 1997 and 1998. Compared with Europeans, Māori and Pacific Islanders consumed more energy per day. Carbohydrate, protein and fat intakes were higher in Māori and Pacific Islanders than in Europeans. Cholesterol intakes were lowest in Europeans and alcohol intakes were highest in Europeans and Māori. When nutrient intakes were expressed as their percentage contribution to total energy, many ethnic differences in nutrient intakes between Europeans and Māori or Pacific Islanders were eliminated. After adjustment for energy intake and age, Europeans ate the fewest eggs, and Pacific Islanders and Asians ate more servings of chicken and fish, and fewer servings of milk and cereal than Europeans. Compared to Europeans, Pacific Islanders consumed larger portion sizes for nearly every food item. There were marked differences in nutrient intakes between Pacific, Māori, Asian and European adolescents. Ethnic differences in food selections, frequency of food servings and portion sizes contribute to the differences in nutrient intakes between these ethnic groups. These differences generally matched those of other studies in children and adults from these ethnic groups. Interventions that reduce frequency of food consumption and serving sizes and promote less-fatty food choices in Māori and Pacific adolescents are needed. © 2010 The Authors. Journal Compilation © 2010 Public Health Association of Australia.

Neoliberalism and indigenous knowledge: Māori health research and the cultural politics of New Zealand's "National Science Challenges".

PubMed

Prussing, Erica; Newbury, Elizabeth

2016-02-01

In 2012-13 the Ministry of Business, Innovation and Employment (MBIE) in New Zealand rapidly implemented a major restructuring of national scientific research funding. The "National Science Challenges" (NSC) initiative aims to promote greater commercial applications of scientific knowledge, reflecting ongoing neoliberal reforms in New Zealand. Using the example of health research, we examine the NSC as a key moment in ongoing indigenous Māori advocacy against neoliberalization. NSC rhetoric and practice through 2013 moved to marginalize participation by Māori researchers, in part through constructing "Māori" and "science" as essentially separate arenas-yet at the same time appeared to recognize and value culturally distinctive forms of Māori knowledge. To contest this "neoliberal multiculturalism," Māori health researchers reasserted the validity of culturally distinctive knowledge, strategically appropriated NSC rhetoric, and marshalled political resources to protect Māori research infrastructure. By foregrounding scientific knowledge production as an arena of contestation over neoliberal values and priorities, and attending closely to how neoliberalizing tactics can include moves to acknowledge cultural diversity, this analysis poses new questions for social scientific study of global trends toward reconfiguring the production of knowledge about health. Study findings are drawn from textual analysis of MBIE documents about the NSC from 2012 to 2014, materials circulated by Māori researchers in the blogosphere in 2014, and ethnographic interviews conducted in 2013 with 17 Māori health researchers working at 7 sites that included university-based research centers, government agencies, and independent consultancies. Copyright © 2015 Elsevier Ltd. All rights reserved.

The voyage to McDonalds--short and long-term factors in the etiology of obesity in Mäori children in Aotearoa.

PubMed

Gray, George

2003-09-01

In Aotearoa, it has been revealed that 14.7% of European adults are obese, compared with 27.5% for Mäori adults. It has been difficult to elucidate the recent trends in children and adolescents without large-scale population analysis, but a recent study of obesity in Auckland schoolchildren revealed a prevalence rate of 15.8% for Mäori children, compared with 8.6% for European children. This essay will review factors affecting the etiology of obesity in Mäori children. The classification of obesity will be examined before a discussion of short-term and long-term factors leading to obesity in this ethnic group. Measuring Obesity in Children It has been recommended that the BMI range for overweight in Mäori be increased to 27-32, and obesity a BMI greater than 32. Unfortunately though, there is no consensus among researchers and some studies may use the conventional obesity range of a BMI greater than 30 for both Mäori and non-Mäori children. Mäori disproportionately occupy low socioeconomic strata in Aotearoa. The significant discrepancy between obesity prevalence rates for Mäori and European children indicates that other factors are involved. Dietary fat intake, and by extension obesity, tend to be more prevalent for people in low socioeconomic groups, as numerous studies have shown. Therefore, the Mäori-European obesity discrepancy can be further explained by the discrepancy in socioeconomic status between these two groups, as national census data reveal that Mäori are disproportionately represented in all negative socioeconomic indices. However, for completeness, it is necessary to understand exactly why Mäori dominate these indices.

Perceptions of New Zealand nutrition labels by Māori, Pacific and low-income shoppers.

PubMed

Signal, Louise; Lanumata, Tolotea; Robinson, Jo-Ani; Tavila, Aliitasi; Wilton, Jenny; Ni Mhurchu, Cliona

2008-07-01

In New Zealand the burden of nutrition-related disease is greatest among Māori, Pacific and low-income peoples. Nutrition labels have the potential to promote healthy food choices and eating behaviours. To date, there has been a noticeable lack of research among indigenous peoples, ethnic minorities and low-income populations regarding their perceptions, use and understanding of nutrition labels. Our aim was to evaluate perceptions of New Zealand nutrition labels by Māori, Pacific and low-income peoples and to explore improvements or alternatives to current labelling systems. Māori, Samoan and Tongan researchers recruited participants who were regular food shoppers. Six focus groups were conducted which involved 158 people in total: one Māori group, one Samoan, one Tongan, and three low-income groups. Māori, Pacific and low-income New Zealanders rarely use nutrition labels to assist them with their food purchases for a number of reasons, including lack of time to read labels, lack of understanding, shopping habits and relative absence of simple nutrition labels on the low-cost foods they purchase. Current New Zealand nutrition labels are not meeting the needs of those who need them most. Possible improvements include targeted social marketing and education campaigns, increasing the number of low-cost foods with voluntary nutrition labels, a reduction in the price of 'healthy' food, and consideration of an alternative mandatory nutrition labelling system that uses simple imagery like traffic lights.

ORNL’s ORiGAMI Uses Big Data to Help Solve Age-Old Medical Mysteries in Seconds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sukumar, Rangan

ORiGAMI is a tool for discovering and evaluating potentially interesting associations and creating novel hypothesis in medicine. ORiGAMI will help you “connect the dots” across 70 million knowledge nuggets published in 23 million papers in the medical literature.

Let's kōrero (talk): the practice and functions of reminiscing among mothers and children in Māori families.

PubMed

Reese, Elaine; Neha, Tia

2015-01-01

Māori adults recall earlier memories than New Zealand European or Chinese adults, highlighting the importance of memory in Māori culture. In this study, Māori preschool children and their mothers (N = 41) reminisced about a diverse range of past events, including everyday events, the child's birth, cultural rituals and the child's misbehaviour. Mothers also reported how frequently they discussed past events with their children, as well as their level of affiliation with Māori culture. Mothers who reported higher levels of cultural affiliation also reported reminiscing more frequently about a diverse range of past events. Mothers reminisced in more elaborative ways about everyday events with their children compared to birth stories, cultural rituals and misbehaviours. Maternal reminiscing about cultural rituals and misbehaviours, however, along with maternal reminiscing about everyday events and birth stories, were significantly correlated with children's memory across conversations. These results underscore the continued importance of reminiscing about culturally relevant events in Māori culture, and the newfound importance for Māori families of reminiscing about everyday events.

VizieR Online Data Catalog: The G+M eclipsing binary V530 Orionis photometry (Torres+, 2014)

NASA Astrophysics Data System (ADS)

Torres, G.; Lacy, C. H. S.; Pavlovski, K.; Feiden, G. A.; Sabby, J. A.; Bruntt, H.; Clausen, J. V.

2017-08-01

V530 Ori was monitored spectroscopically with three different instruments over a period of more than 17 yr. Observations began at the Harvard-Smithsonian Center for Astrophysics (CfA) in 1996 June with a Cassegrain-mounted echelle spectrograph ("Digital Speedometer", DS; Latham 1992ASPC...32..110L) attached to the 1.5 m Tillinghast reflector at the F. L. Whipple Observatory (Mount Hopkins, AZ). We gathered a further 30 spectra of V530 Ori at the Kitt Peak National Observatory (KPNO) from 1999 March to 2001 January, using the coude-feed telescope and the coude spectrometer. Finally, 41 additional observations were obtained at the CfA from 2009 November to 2014 March with the Tillinghast Reflector Echelle Spectrograph (TRES; Furesz 2008, PhD thesis , Univ. Szeged, Hungary) on the 1.5 m telescope mentioned earlier. Two sets of V-band images of V530 Ori were obtained with independent robotic telescopes operating at the University of Arkansas (URSA WebScope) and near Silver City, NM (NFO WebScope) from 2001 January to 2012 February. Differential photometric measurements of V530 Ori were also gathered with the Stromgren Automatic Telescope at ESO (La Silla, Chile), during several campaigns from 2001 January to 2006 February. (5 data files).

Whakawhanaungatanga: the importance of culturally meaningful connections to improve uptake of pulmonary rehabilitation by Māori with COPD - a qualitative study.

PubMed

Levack, William Mm; Jones, Bernadette; Grainger, Rebecca; Boland, Pauline; Brown, Melanie; Ingham, Tristram R

2016-01-01

Pulmonary rehabilitation is known to improve function and quality of life for people with chronic obstructive pulmonary disease (COPD). However, little research has been conducted on the influence of culture on experiences of pulmonary rehabilitation. This study examined factors influencing uptake of pulmonary rehabilitation by Māori with COPD in New Zealand. Grounded theory nested within kaupapa Māori methodology. Transcripts were analyzed from interviews and focus groups with 15 Māori and ten New Zealand non-Māori invited to attend pulmonary rehabilitation for COPD. Māori participants had either attended a mainstream hospital-based program, a community-based program designed "by Māori, for Māori", or had experienced both. Several factors influencing uptake of pulmonary rehabilitation were common to all participants regardless of ethnicity: 1) participants' past experiences (eg, of exercise; of health care systems), 2) attitudes and expectations, 3) access issues (eg, time, transport, and conflicting responsibilities), and 4) initial program experiences. These factors were moderated by the involvement of family and peers, interactions with health professionals, the way information on programs was presented, and by new illness events. For Māori, however, several additional factors were also identified relating to cultural experiences of pulmonary rehabilitation. In particular, Māori participants placed high value on whakawhanaungatanga: the making of culturally meaningful connections with others. Culturally appropriate communication and relationship building was deemed so important by some Māori participants that when it was absent, they felt strongly discouraged to attend pulmonary rehabilitation. Only the more holistic services offered a program in which they felt culturally safe and to which they were willing to return for ongoing rehabilitation. Lack of attention to cultural factors in the delivery of pulmonary rehabilitation may be a barrier to its

Sidney Blatt's Object Relations Inventory: Contributions and Future Directions.

PubMed

Huprich, Steven K; Auerbach, John S; Porcerelli, John H; Bupp, Lindsey L

2016-01-01

In this article, we provide a historical overview of the Object Relations Inventory (ORI) and related methods for the assessment of object relations constructed by Sidney Blatt and colleagues (e.g., Blatt, Bers, & Schaffer, 1992 ; Blatt, Wein, Chevron, & Quinlan, 1979 ; Diamond, Kaslow, Coonerty, & Blatt, 1990 ). We clarify terminology that has been used inconsistently in the literature, especially by way of differentiating the methods used to collect descriptions of significant figures, such as the ORI and its predecessor, the Parental Description (PD) task, and the rating scales that Blatt and colleagues constructed to rate those descriptions. We provide a tabular summary of empirical studies of the measure and offer a critical review of those aspects of the instrument that require further empirical investigation and methodological rigor.

The lytic origin of herpesvirus papio is highly homologous to Epstein-Barr virus ori-Lyt: evolutionary conservation of transcriptional activation and replication signals.

PubMed Central

Ryon, J J; Fixman, E D; Houchens, C; Zong, J; Lieberman, P M; Chang, Y N; Hayward, G S; Hayward, S D

1993-01-01

Herpesvirus papio (HVP) is a B-lymphotropic baboon virus with an estimated 40% homology to Epstein-Barr virus (EBV). We have cloned and sequenced ori-Lyt of herpesvirus papio and found a striking degree of nucleotide homology (89%) with ori-Lyt of EBV. Transcriptional elements form an integral part of EBV ori-Lyt. The promoter and enhancer domains of EBV ori-Lyt are conserved in herpesvirus papio. The EBV ori-Lyt promoter contains four binding sites for the EBV lytic cycle transactivator Zta, and the enhancer includes one Zta and two Rta response elements. All five of the Zta response elements and one of the Rta motifs are conserved in HVP ori-Lyt, and the HVP DS-L leftward promoter and the enhancer were activated in transient transfection assays by the EBV Zta and Rta transactivators. The EBV ori-Lyt enhancer contains a palindromic sequence, GGTCAGCTGACC, centered on a PvuII restriction site. This sequence, with a single base change, is also present in the HVP ori-Lyt enhancer. DNase I footprinting demonstrated that the PvuII sequence was bound by a protein present in a Raji nuclear extract. Mobility shift and competition assays using oligonucleotide probes identified this sequence as a binding site for the cellular transcription factor MLTF. Mutagenesis of the binding site indicated that MLTF contributes significantly to the constitutive activity of the ori-Lyt enhancer. The high degree of conservation of cis-acting signal sequences in HVP ori-Lyt was further emphasized by the finding that an HVP ori-Lyt-containing plasmid was replicated in Vero cells by a set of cotransfected EBV replication genes. The central domain of EBV ori-Lyt contains two related AT-rich palindromes, one of which is partially duplicated in the HVP sequence. The AT-rich palindromes are functionally important cis-acting motifs. Deletion of these palindromes severely diminished replication of an ori-Lyt target plasmid. Images PMID:8389916

Risk of stomach cancer in Aotearoa/New Zealand: A Māori population based case-control study

PubMed Central

Sporle, Andrew; Corbin, Marine; Cheng, Soo; Harawira, Pauline; Gray, Michelle; Whaanga, Tracey; Guilford, Parry; Koea, Jonathan; Pearce, Neil

2017-01-01

Māori, the indigenous people of New Zealand, experience disproportionate rates of stomach cancer, compared to non-Māori. The overall aim of the study was to better understand the reasons for the considerable excess of stomach cancer in Māori and to identify priorities for prevention. Māori stomach cancer cases from the New Zealand Cancer Registry between 1 February 2009 and 31 October 2013 and Māori controls, randomly selected from the New Zealand electoral roll were matched by 5-year age bands to cases. Logistic regression was used to estimate odd ratios (OR) and 95% confidence intervals (CI) between exposures and stomach cancer risk. Post-stratification weighting of controls was used to account for differential non-response by deprivation category. The study comprised 165 cases and 480 controls. Nearly half (47.9%) of cases were of the diffuse subtype. There were differences in the distribution of risk factors between cases and controls. Of interest were the strong relationships seen with increased stomach risk and having >2 people sharing a bedroom in childhood (OR 3.30, 95%CI 1.95–5.59), testing for H pylori (OR 12.17, 95%CI 6.15–24.08), being an ex-smoker (OR 2.26, 95%CI 1.44–3.54) and exposure to environmental tobacco smoke in adulthood (OR 3.29, 95%CI 1.94–5.59). Some results were attenuated following post-stratification weighting. This is the first national study of stomach cancer in any indigenous population and the first Māori-only population-based study of stomach cancer undertaken in New Zealand. We emphasize caution in interpreting the findings given the possibility of selection bias. Population-level strategies to reduce the incidence of stomach cancer in Māori include expanding measures to screen and treat those infected with H pylori and a continued policy focus on reducing tobacco consumption and uptake. PMID:28732086

Do community-dwelling Māori and Pacific peoples present with dementia at a younger age and at a later stage compared with NZ Europeans?

PubMed

Cullum, Sarah; Mullin, Katherine; Zeng, Irene; Yates, Susan; Payman, Vahid; Fisher, Mark; Cheung, Gary

2018-05-15

Ethnicity may affect presentation to clinical services in people with dementia; however, no studies have examined this in Māori or Pacific peoples in New Zealand (NZ). Our objective was to examine the routinely collected clinical data from a memory assessment service in South Auckland to examine the presentation of dementia in the major NZ ethnic groups. A total of 360 patients presenting to a memory service with a new diagnosis of dementia were included in this study. Demographic data (age, sex, and ethnicity) and dementia sub-type and severity were analyzed. There were 142 NZ European (mean age: 79.2, SD 7.4), 43 Māori (mean age: 70.2, SD 7.6), 126 Pacific (mean age: 74.3, SD 7.6), and 49 other ethnicities (mean age: 78.0, SD 8.5) presenting with a new diagnosis of dementia. After adjustment for gender and dementia subtype, Māori and Pacific patients were 8.5 and 5.3 years younger than NZ European patients (P < 0.0001). Pacific peoples tended to present with more advanced dementia (OR = 1.63, 95% CI: 0.98-2.70, P = 0.06) after adjustment for age and gender. There was little difference in the subtypes of dementia between ethnic groups. Māori and Pacific peoples with dementia presented to an NZ memory service at a younger age than NZ Europeans, and Pacific peoples presented with more advanced dementia. A population-based epidemiological study is critical to determine whether Māori and Pacific peoples have indeed a higher risk of developing dementia at a younger age. Copyright © 2018 John Wiley & Sons, Ltd.

HIGHLY VARIABLE EXTINCTION AND ACCRETION IN THE JET-DRIVING CLASS I-TYPE YOUNG STAR PTF 10nvg (V2492 Cyg, IRAS 20496+4354)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hillenbrand, Lynne A.; Carpenter, John M.; Muirhead, Philip S.

2013-03-15

against the broad H{alpha} and Ca II triplet emission lines, similarly are formed in the outflow. CARMA maps resolve on larger scales a spatially extended outflow in millimeter-wavelength CO. We attribute the recently observed photometric and spectroscopic behavior to rotating circumstellar disk material located at separation a Almost-Equal-To 0.7(M{sub *}/M{sub Sun }){sup 1/3} AU from the continuum source, causing the semi-periodic dimming. Occultation of the central star as well as the bright inner disk and the accretion/outflow zones renders shocked gas in the inner part of the jet amenable to observation at the faint epochs. We discuss PTF 10nvg as a source exhibiting both accretion-driven (perhaps analogous to V1647 Ori) and extinction-driven (perhaps analogous to UX Ori or GM Cep) high-amplitude variability phenomena.« less

Oak Ridge Graph Analytics for Medical Innovation (ORiGAMI)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, Larry W.; Lee, Sangkeun

2016-01-01

In this era of data-driven decisions and discovery where Big Data is producing Bigger Data, data scientists at the Oak Ridge National Laboratory are leveraging unique leadership infrastructure (e.g., Urika XA and Urika GD appliances) to develop scalable algorithms for semantic, logical and statistical reasoning with Big Data (i.e., data stored in databases as well as unstructured data in documents). ORiGAMI is a next-generation knowledge-discovery framework that is: (a) knowledge nurturing (i.e., evolves seamlessly with newer knowledge and data), (b) smart and curious (i.e. using information-foraging and reasoning algorithms to digest content) and (c) synergistic (i.e., interfaces computers with whatmore » they do best to help subject-matter-experts do their best. ORiGAMI has been demonstrated using the National Library of Medicine's SEMANTIC MEDLINE (archive of medical knowledge since 1994).« less

B, V, and R Band Photometry of Trans-Neptunian Objects and Centaur Objects

NASA Astrophysics Data System (ADS)

Tegler, S.; Romanishin, W.; Levine, J.; Butler, N.

1996-09-01

We present a progress report on our program at the Steward Observatory 2.3-m Telescope on Kitt Peak, Arizona to carry out B, V, and R band photometry of Trans-Neptunian Objects (TNOs) and Centaur Objects. The goal of our program is to answer the following first order questions: (1) Is there color diversity and hence surface composition diversity among TNOs? (2) What is the mechanism responsible for the diversity among Centaurs (and possibly TNOs)? We present B, V, and R band photometry of two TNOs (1994 TB and 1993 SC) and four Centaurs (1995 GO, 1993 HA2, 5145 Pholus, and 2060 Chiron). We find that 1994 TB, 1993 SC, 1993 HA2, and 5145 Pholus are among the reddest objects in the solar system and 1995 GO and 2060 Chiron are solar in color. In order to determine whether a diversity exists among TNOs and the nature of the mechanism responsible for the diversity among Cenaturs, we present our colors as well as colors in the literature on two diagrams: (1) a B-V vs V-R diagram and (2) a V-R vs semi-major axis diagram. We draw a number of interesting conclusions from these diagrams. However, colors are needed for many more objects before firm conclusions can be drawn. This research is sponsored by the NASA Origins of Solar Systems Program. J. L. and N. B. thank the NSF Research Experience for Undergraduates Program at Northern Arizona University.

An indigenous approach to explore health-related experiences among Māori parents: the Pukapuka Hauora asthma study

PubMed Central

2013-01-01

Background The prevalence of asthma for Indigenous New Zealand Māori is amongst the highest in the world. Recent evidence shows ethnic differences in asthma symptom prevalence in New Zealand have widened, with asthma symptoms and hospitalisation rates consistently higher for Māori across all age-groups, especially children and adolescents. This paper: outlines our qualitative, longitudinal research exploring the practical issues Māori children and their families face trying to achieve optimum asthma outcomes; details the research methods used within this study; and discusses the process evaluation findings of the features that made this approach successful in engaging and retaining participants in the study. Methods Thirty-two Māori families were recruited using a Kaupapa Māori (Māori way) Research approach. Each participated in a series of four in-depth interviews that were carried out at seasonal intervals over the course of one year. Families also took part in an interviewer-administered questionnaire and participated in a Photovoice exercise. All interviews were digitally recorded, transcribed verbatim and independently coded by two researchers. The research team then conducted the analysis and theme development. The questionnaires were analysed separately, with explanations for findings explored within the qualitative data. Results The methodology produced a 100 percent retention rate of the participating families over the course of the follow-up. This was attributed to the research collaboration, the respectful research relationships established with families, and the families’ judgement that the methods used enabled them to tell their stories. The acceptability of the methodology will add to the validity and trustworthiness of the findings. Conclusion Given the extent and persistence of ethnic disparities in childhood asthma management, it is imperative that an indigenous approach be taken to understanding the core issues facing Māori families. By

Radio continuum from FU Orionis stars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodriguez, L.F.; Hartmann, L.W.; Chavira, E.

1990-12-01

Using the very large array a sensitive search is conducted for 3.6-cm continuum emission toward four FU Orionis objects: FU Ori, V1515 Cyg, V1057 Cyg, and Elias 1-12. V1057 Cyg and Elias 1-12 at the level of about 0.1 mJy is detected. The association of radio continuum emission with these FU Ori objects strengthens a possible relation between FU Ori stars and objects like L 1551 IRS 5 and Z CMa that are also sources of radio continuum emission and have been proposed as post-FU Ori objects. Whether the radio continuum emission is caused by free-free emission from ionized ejectamore » or if it is optically thin emission from a dusty disk is discussed. It was determined that, in the archives of the Tonantzintla Observatory, a plate taken in 1957 does not show Elias 1-12. This result significantly narrows the time range for the epoch of the outburst of this source to between 1957 and 1965. 38 refs.« less

DNA recombination-initiation plays a role in the extremely biased inheritance of yeast [rho-] mitochondrial DNA that contains the replication origin ori5.

PubMed

Ling, Feng; Hori, Akiko; Shibata, Takehiko

2007-02-01

Hypersuppressiveness, as observed in Saccharomyces cerevisiae, is an extremely biased inheritance of a small mitochondrial DNA (mtDNA) fragment that contains a replication origin (HS [rho(-)] mtDNA). Our previous studies showed that concatemers (linear head-to-tail multimers) are obligatory intermediates for mtDNA partitioning and are primarily formed by rolling-circle replication mediated by Mhr1, a protein required for homologous mtDNA recombination. In this study, we found that Mhr1 is required for the hypersuppressiveness of HS [ori5] [rho(-)] mtDNA harboring ori5, one of the replication origins of normal ([rho(+)]) mtDNA. In addition, we detected an Ntg1-stimulated double-strand break at the ori5 locus. Purified Ntg1, a base excision repair enzyme, introduced a double-stranded break by itself into HS [ori5] [rho(-)] mtDNA at ori5 isolated from yeast cells. Both hypersuppressiveness and concatemer formation of HS [ori5] [rho(-)] mtDNA are simultaneously suppressed by the ntg1 null mutation. These results support a model in which, like homologous recombination, rolling-circle HS [ori5] [rho(-)] mtDNA replication is initiated by double-stranded breakage in ori5, followed by Mhr1-mediated homologous pairing of the processed nascent DNA ends with circular mtDNA. The hypersuppressiveness of HS [ori5] [rho(-)] mtDNA depends on a replication advantage furnished by the higher density of ori5 sequences and on a segregation advantage furnished by the higher genome copy number on transmitted concatemers.

42 CFR 93.318 - Notifying ORI of special circumstances.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Notifying ORI of special circumstances. 93.318 Section 93.318 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE...

42 CFR 93.318 - Notifying ORI of special circumstances.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Notifying ORI of special circumstances. 93.318 Section 93.318 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE...

42 CFR 93.318 - Notifying ORI of special circumstances.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Notifying ORI of special circumstances. 93.318 Section 93.318 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE...

42 CFR 93.318 - Notifying ORI of special circumstances.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Notifying ORI of special circumstances. 93.318 Section 93.318 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE...

42 CFR 93.318 - Notifying ORI of special circumstances.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Notifying ORI of special circumstances. 93.318 Section 93.318 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE...

Provider, father, and bro--Sedentary Māori men and their thoughts on physical activity.

PubMed

Warbrick, Isaac; Wilson, Denise; Boulton, Amohia

2016-02-04

Māori (indigenous peoples of New Zealand) men have a disproportionate prevalence of lifestyle-related illnesses and are targeted for national physical activity initiatives. While physical activity impacts on physical and mental health and overall wellbeing, current approaches to health promotion often lack cultural relevance. Having better understanding and incorporating relevant cultural values and motivators into program designs could improve the success of health initiatives for indigenous and minority men. Nevertheless, little is known about Māori men's preferences, attitudes, or perspectives about physical activity, which are often interpreted through a colonized or dominant Western lens. Understanding perspectives of those groups whose values do not align with dominant cultural approaches will better equip health promoters and trainers to develop relevant community initiatives and private programs for indigenous and minority men. An indigenous research approach informed a qualitative study with 18 sedentary, 'overweight' Māori men aged 28 to 72 years. From 2014 to 2015 these men participated in three focus group discussions aimed at understanding their views about physical activity and exercise. Data were thematically analysed and interpeted using a Māori worldview. Four key themes were identified - Cameraderie and 'Bro-ship'; Adulthood Distractions and Priorities; Problems with Contemporary Gym Culture; and Provider Orientation. Key motivators for physical activity included a sense of 'brotherhood' in sport and physical activity and accountability to others. Participants reported the need to highlight the value of people and relationships, and having an orientation to the collective to enhance physical activity experiences for Māori men in general. Modern lifestyle distractions (such as being time deficient, and family responsibilities) along with other priorities contributed to difficulties incorporating physical activity into their daily lives. In

A Puzzling Object - V348-SAGITTARIUS

NASA Astrophysics Data System (ADS)

Houziaux, L.

1983-09-01

V 348 Sagitarii is one of the many variables discovered by Miss Ida Woods on Harvard plates (Harvard Bulletin 838, 1926). Later, in the 1950s, 500 patrol plates have been scrutinized by Mrs. Jean Haies Anderson (Hoffleit, Astronomical Journal, 63, 78, 1958) at Maria Mitchell Observatory. This material covered the period 1906-1939 and the derived light Curve suggested a semi-regular variability with cycles of 200 to 400 days. Because of the resemblance of its light curve with the ones of stars undergoing at irregular intervals sudden drops of brightness before recovering more slowly their previous magnitude, that star was once classified as belonging to the R Coronae Borealis type by Schjan, who rediscovered the star in 1929 and gave it the number 3976 in the H(amburg) V(ariables) catalogue (Astronomische Nachrichten, 235, 417, 1929). V 348 Sgr, however, is seen more often at minimum light than at maximum, contrarily to the R Coronae Borealis stars. These objects are known to be carbon rich and this is indeed the case for V 348 Sgr; however, as shown first by George Herbig (Astrophysical Journal, 127, 312, 1958) the spectrum, unlike the other stars of the type reveals the presence of a hot diluted atmosphere around the star where many lines of ionized atoms of carbon are seen instead of absorption bands due to molecular compounds. So both by its light curve and by its spectrum V 348 Sgr is indeed a peculiar object.

42 CFR 93.400 - General statement of ORI authority.

Code of Federal Regulations, 2010 CFR

2010-10-01

... POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services... 42 Public Health 1 2010-10-01 2010-10-01 false General statement of ORI authority. 93.400 Section 93.400 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH...

42 CFR 93.400 - General statement of ORI authority.

Code of Federal Regulations, 2011 CFR

2011-10-01

... POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services... 42 Public Health 1 2011-10-01 2011-10-01 false General statement of ORI authority. 93.400 Section 93.400 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH...

Genetics and Cell Morphology Analyses of the Actinomyces oris srtA Mutant.

PubMed

Wu, Chenggang; Reardon-Robinson, Melissa Elizabeth; Ton-That, Hung

2016-01-01

Sortase is a cysteine-transpeptidase that anchors LPXTG-containing proteins on the Gram-positive bacterial cell wall. Previously, sortase was considered to be an important factor for bacterial pathogenesis and fitness, but not cell growth. However, the Actinomyces oris sortase is essential for cell viability, due to its coupling to a glycosylation pathway. In this chapter, we describe the methods to generate conditional srtA deletion mutants and identify srtA suppressors by Tn5 transposon mutagenesis. We also provide procedures for analyzing cell morphology of this mutant by thin-section electron microscopy. These techniques can be applied for analyses of other essential genes in A. oris.

MOST Observations of σ Ori E: Challenging the Centrifugal Breakout Narrative

NASA Astrophysics Data System (ADS)

Townsend, R. H. D.; Rivinius, Th.; Rowe, J. F.; Moffat, A. F. J.; Matthews, J. M.; Bohlender, D.; Neiner, C.; Telting, J. H.; Guenther, D. B.; Kallinger, T.; Kuschnig, R.; Rucinski, S. M.; Sasselov, D.; Weiss, W. W.

2013-05-01

We present results from three weeks' photometric monitoring of the magnetic helium-strong star σ Ori E using the Microvariability and Oscillations of Stars microsatellite. The star's light curve is dominated by twice-per-rotation eclipse-like dimmings arising when magnetospheric clouds transit across and occult the stellar disk. However, no evidence is found for any abrupt centrifugal breakout of plasma from the magnetosphere, either in the residual flux or in the depths of the light minima. Motivated by this finding we compare the observationally inferred magnetospheric mass against that predicted by a breakout analysis. The large discrepancy between the values leads us to argue that centrifugal breakout does not play a significant role in establishing the magnetospheric mass budget of σ Ori E.

Working with racism: a qualitative study of the perspectives of Māori (indigenous peoples of Aotearoa New Zealand) registered nurses on a global phenomenon.

PubMed

Huria, Tania; Cuddy, Jessica; Lacey, Cameron; Pitama, Suzanne

2014-10-01

Substantial health disparities exist between Māori--the indigenous people of Aotearoa New Zealand--and non-Māori New Zealanders. This article explores the experience and impact of racism on Māori registered nurses within the New Zealand health system. The narratives of 15 Māori registered nurses were analyzed to identify the effects of racism. This Māori nursing cohort and the data on racism form a secondary analysis drawn from a larger research project investigating the experiences of indigenous health workers in New Zealand and Canada. Jones's levels of racism were utilized as a coding frame for the structural analysis of the transcribed Māori registered nurse interviews. Participants experienced racism on institutional, interpersonal, and internalized levels, leading to marginalization and being overworked yet undervalued. Māori registered nurses identified a lack of acknowledgement of dual nursing competencies: while their clinical skills were validated, their cultural skills-their skills in Hauora Māori--were often not. Experiences of racism were a commonality. Racism--at every level--can be seen as highly influential in the recruitment, training, retention, and practice of Māori registered nurses. The nursing profession in New Zealand and other countries of indigenous peoples needs to acknowledge the presence of racism within training and clinical environments as well as supporting indigenous registered nurses to develop and implement indigenous dual cultural-clinical competencies. © The Author(s) 2014.

Redesigning the architecture of policy-making: Engaging with Māori on nanotechnology in New Zealand.

PubMed

Munshi, Debashish; Kurian, Priya A; Morrison, Talei; Morrison, Sandra L

2016-04-01

Although there is an extensive literature on public engagement on the use of new and emerging technologies such as nanotechnology, there is little evidence of the participation of marginalised indigenous communities in processes of such engagement. How do particular cultural values and worldviews shape the perceptions of new technologies among such indigenous peoples? This article addresses this question through an analysis of the deliberations of an indigenous Māori citizens' panel on nanotechnology in Aotearoa New Zealand. An active process of public engagement with the nation's Māori stakeholders, and their conversations with nanotechnology experts, sustainability activists and Māori researchers, helps map an alternative, culture-based architecture of public engagement on policies around new technologies. The analysis is grounded in a concept of active citizenship that we term 'sustainable citizenship'. © The Author(s) 2014.

Lactobacillus johnsonii CRL1647, isolated from Apis mellifera L. bee-gut, exhibited a beneficial effect on honeybee colonies.

PubMed

Audisio, M C; Benítez-Ahrendts, M R

2011-03-01

Lactobacillus johnsonii CRL1647, isolated from the intestinal tract of a honeybee and selected due to its high lactic acid production, was assayed as a monoculture on bee colony performance. It was delivered to the bees on a one litre of 125 g/l sugar-cane syrup with a final concentration of 105 cfu/ml lactobacilli. The bees accepted the new nourishment, which was consumed within 24-48 h and was administered in two independent trials (every 14-15 days for 3 consecutive months in one case, and once a month for 13 consecutive months in the other). From late spring - early summer (2008) the photo-records and statistical analyses revealed significant differences in the open and the operculated brood areas in the treated group compared with the control. This stimulation was observed after the first administration of the lactobacilli and maintained throughout. Also, a higher number of bees were measured in the treated group (54%) and the control (18%) with respect to the initial bees' number. Furthermore, honey storage was higher, 40% and 19%, for the treated and control groups, respectively. From December 2008 to December 2009, a similar situation was observed even though, in this trial, the lactobacilli cells were administered once a month. The in vivo results of this study are promising and indicate that a L. johnsonii CRL1647 supplement to beehives favours mainly open and operculated brood areas, demonstrating a stronger stimulation of egg-laying and will become a natural product which will assist the beekeeper both in colony management and the creation of late nuclei and/or bee packages due to its beneficial effects in the beehive colony.

High nutrition risk related to dietary intake is associated with an increased risk of hospitalisation and mortality for older Māori: LiLACS NZ.

PubMed

North, Sylvia M; Wham, Carol A; Teh, Ruth; Moyes, Simon A; Rolleston, Anna; Kerse, Ngaire

2018-06-11

To investigate the association between domains of nutrition risk with hospitalisations and mortality for New Zealand Māori and non-Māori in advanced age. Within LiLACS NZ, 256 Māori and 399 non-Māori octogenarians were assessed for nutrition risk using the Seniors in the Community: Risk Evaluation for Eating and Nutrition (SCREEN II) questionnaire according to three domains of risk. Sociodemographic and health characteristics were established. Five years from inception, survival analyses examined associations between nutrition risk from the three domains of SCREEN II with all-cause hospital admissions and mortality. For Māori but not non-Māori, lower nutrition risk in the Dietary Intake domain was associated with reduced hospitalisations and mortality (Hazard Ratios [HR] [95%CI] 0.97 [0.95-0.99], p=0.009 and 0.91 [0.86-0.98], p=0.005, respectively). The 'Factors Affecting Intake' domain was associated with mortality (HR, [95%CI] 0.94 [0.89-1.00], p=0.048), adjusted for age, gender, socioeconomic deprivation, education, previous hospital admissions, comorbidities and activities of daily living. Improved dietary adequacy may reduce poor outcomes for older Māori. Implications for public health: Nutrition risk among older Māori is identifiable and treatable. Effort is needed to engage relevant community and whānau (family) support to ensure older Māori have food security and cultural food practices are met. © 2018 The Authors.

Observed Luminosity Spread in Young Clusters and FU Ori Stars: A Unified Picture

NASA Astrophysics Data System (ADS)

Baraffe, I.; Vorobyov, E.; Chabrier, G.

2012-09-01

The idea that non-steady accretion during the embedded phase of protostar evolution can produce the observed luminosity spread in the Herzsprung-Russell diagram (HRD) of young clusters has recently been called into question. Observations of FU Ori, for instance, suggest an expansion of the star during strong accretion events, whereas the luminosity spread implies a contraction of the accreting objects, decreasing their radiating surface. In this paper, we present a global scenario based on calculations coupling episodic accretion histories derived from numerical simulations of collapsing cloud prestellar cores of various masses and subsequent protostar evolution. Our calculations show that, assuming an initial protostar mass Mi ~ 1 M Jup, typical of the second Larson's core, both the luminosity spread in the HRD and the inferred properties of FU Ori events (mass, radius, accretion rate) can be explained by this scenario, providing two conditions. First, there must be some variation within the fraction of accretion energy absorbed by the protostar during the accretion process. Second, the range of this variation should increase with increasing accretion burst intensity and thus with the initial core mass and final star mass. The numerical hydrodynamics simulations of collapsing cloud prestellar cores indeed show that the intensity of the accretion bursts correlates with the mass and initial angular momentum of the prestellar core. Massive prestellar cores with high initial angular momentum are found to produce intense bursts characteristic of FU Ori-like events. Our results thus suggest a link between the burst intensities and the fraction of accretion energy absorbed by the protostar, with some threshold in the accretion rate, of the order of 10-5 M ⊙ yr-1, delimitating the transition from "cold" to "hot" accretion. Such a transition might reflect a change in the accretion geometry with increasing accretion rate, i.e., a transition from magnetospheric or thin

A CANDIDATE PLANETARY-MASS OBJECT WITH A PHOTOEVAPORATING DISK IN ORION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fang, Min; Kim, Jinyoung Serena; Apai, Dániel

2016-12-20

In this work, we report the discovery of a candidate planetary-mass object with a photoevaporating protoplanetary disk, Proplyd 133-353, which is near the massive star θ {sup 1} Ori C at the center of the Orion Nebula Cluster (ONC). The object was known to have extended emission pointing away from θ {sup 1} Ori C, indicating ongoing external photoevaporation. Our near-infrared spectroscopic data and the location on the H–R diagram suggest that the central source of Proplyd 133-353 is substellar (∼M9.5) and has a mass probably less than 13 Jupiter mass and an age younger than 0.5 Myr. Proplyd 133-353more » shows a similar ratio of X-ray luminosity to stellar luminosity to other young stars in the ONC with a similar stellar luminosity and has a similar proper motion to the mean one of confirmed ONC members. We propose that Proplyd 133-353 formed in a very low-mass dusty cloud or an evaporating gas globule near θ {sup 1} Ori C as a second generation of star formation, which can explain both its young age and the presence of its disk.« less

ORNL’s ORiGAMI Uses Big Data to Help Solve Age-Old Medical Mysteries in Seconds

ScienceCinema

Sukumar, Rangan

2018-01-16

ORiGAMI is a tool for discovering and evaluating potentially interesting associations and creating novel hypothesis in medicine. ORiGAMI will help you “connect the dots” across 70 million knowledge nuggets published in 23 million papers in the medical literature.

MOST OBSERVATIONS OF {sigma} Ori E: CHALLENGING THE CENTRIFUGAL BREAKOUT NARRATIVE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Townsend, R. H. D.; Rivinius, Th.; Rowe, J. F.

2013-05-20

We present results from three weeks' photometric monitoring of the magnetic helium-strong star {sigma} Ori E using the Microvariability and Oscillations of Stars microsatellite. The star's light curve is dominated by twice-per-rotation eclipse-like dimmings arising when magnetospheric clouds transit across and occult the stellar disk. However, no evidence is found for any abrupt centrifugal breakout of plasma from the magnetosphere, either in the residual flux or in the depths of the light minima. Motivated by this finding we compare the observationally inferred magnetospheric mass against that predicted by a breakout analysis. The large discrepancy between the values leads us tomore » argue that centrifugal breakout does not play a significant role in establishing the magnetospheric mass budget of {sigma} Ori E.« less

Understanding the role of culture in pain: Māori practitioner perspectives relating to the experience of pain.

PubMed

Magnusson, Jane E; Fennell, Joyce A

2011-01-21

As there is growing interest in the role of cultural diversity within healthcare settings it is important to determine how culture can influence such things as pain. A person's culture can impact not only how they perceive and experience pain but also how they interact with healthcare professionals and adhere to advice provided. To better assess and treat pain in different cultures the perspectives and experiences of that culture must be taken into consideration and therefore the present study was undertaken to better understand Māori perspectives of pain. Māori healthcare providers and kaumātua (tribal leaders/elders) were interviewed in order to gain insight into how pain was perceived and expressed by Māori with whom they had health-related interactions. The interviews reflected themes consistent within the greater body of literature in that as with many cultures, Māori perceive pain as a multidimensional experience impacting them physically, psychologically, socially and spiritually. While our findings indicate that there is a commonality between cultures with regard to the experience of pain, it is valuable to understand a culture's perceptions and experiences regarding pain before assessing and treating it as indicated in the findings from this study wherein cultural factors such as the role of the whānau (family) and the importance of the development of relationships with healthcare providers were points of emphasis in terms of ways to enhance Māori health.

The Proximity of Ribosomal Protein Genes to oriC Enhances Vibrio cholerae Fitness in the Absence of Multifork Replication.

PubMed

Soler-Bistué, Alfonso; Timmermans, Michaël; Mazel, Didier

2017-02-28

Recent works suggest that bacterial gene order links chromosome structure to cell homeostasis. Comparative genomics showed that, in fast-growing bacteria, ribosomal protein genes (RP) locate near the replication origin ( oriC ). We recently showed that Vibrio cholerae employs this positional bias as a growth optimization strategy: under fast-growth conditions, multifork replication increases RP dosage and expression. However, RP location may provide advantages in a dosage-independent manner: for example, the physical proximity of the many ribosomal components, in the context of a crowded cytoplasm, may favor ribosome biogenesis. To uncover putative dosage-independent effects, we studied isogenic V. cholerae derivatives in which the major RP locus, S10-spc-α (S10), was relocated to alternative genomic positions. When bacteria grew fast, bacterial fitness was reduced according to the S10 relative distance to oriC The growth of wild-type V. cholerae could not be improved by additional copies of the locus, suggesting a physiologically optimized genomic location. Slow growth is expected to uncouple RP position from dosage, since multifork replication does not occur. Under these conditions, we detected a fitness impairment when S10 was far from oriC Deep sequencing followed by marker frequency analysis in the absence of multifork replication revealed an up to 30% S10 dosage reduction associated with its relocation that closely correlated with fitness alterations. Hence, the impact of S10 location goes beyond a growth optimization strategy during feast periods. RP location may be important during the whole life cycle of this pathogen. IMPORTANCE The role of gene order within the bacterial chromosome is poorly understood. In fast growers, the location of genes linked with the expression of genetic information (i.e., transcription and translation) is biased toward oriC It was proposed that the location of these genes helps to maximize their expression by recruiting

Evidence for recombination between a sialidase (nanH) of Actinomyces naeslundii and Actinomyces oris, previously named ‘Actinomyces naeslundii genospecies 1 and 2’

PubMed Central

Do, Thuy; Henssge, Uta; Gilbert, Steven C; Clark, Douglas; Beighton, David

2008-01-01

Actinomyces spp., predominant members of human oral biofilms, may use extracellular sialidase to promote adhesion, deglycosylate immunoglobulins and liberation of nutrients. Partial nanH gene sequences (1077 bp) from Actinomyces oris (n =74), Actinomyces naeslundii (n =30), Actinomyces viscosus (n =1) and Actinomyces johnsonii (n =2) which included the active-site region and the bacterial neuraminidase repeats (BNRs) were compared. The sequences were aligned and each species formed a distinct cluster with five isolates having intermediate positions. These five isolates (two A. oris and three A. naeslundii) exhibited interspecies recombination. The nonsynonymous/synonymous ratio was <1 for both A. oris and A. naeslundii indicating that nanH in both species is under stabilizing selective pressure; nonsynonymous mutations are not selected. However, for A. oris significant negative values in tests for neutral selection suggested the rate of mutation in A. oris was greater than in A. naeslundii but with selection against nonsynonymous mutations. This was supported by the observation that the frequency of polymorphic sites in A. oris, which were monomorphic in A. naeslundii was significantly greater than the frequency of polymorphic sites in A. naeslundii which were monomorphic in A. oris (χ2=7.011; P =0.00081). The higher proportions of A. oris in the oral biofilm might be explained by the higher mutation rate facilitating an increased ability to respond successfully to environmental stress. PMID:18823396

Confidence and connectedness: Indigenous Māori women's views on personal safety in the context of intimate partner violence.

PubMed

Wilson, Denise; Jackson, Debra; Herd, Ruth

2016-07-01

Māori (New Zealand) women, similar to women belonging to Indigenous and minority groups globally, have high levels of lifetime abuse, assault, and homicide, and are over-represented in events that compromise their safety. We sought insights into how Māori women view safety. Twenty Māori women's narratives revealed safety as a holistic concept involving a number of different elements. We found women had developed an acute sense of the concept of safety. They had firm views and clear strategies to maintain their own safety and that of their female family and friends. These women also provided insights into their experiences of feeling unsafe.

Changes to smoking habits and addiction following tobacco excise tax increases: a comparison of Māori, Pacific and New Zealand European smokers.

PubMed

Tucker, Megan R; Kivell, Bronwyn M; Laugesen, Murray; Grace, Randolph C

2017-02-01

To compare changes in smoking habit and psychological addiction in Māori/Pacific and NZ European smokers in response to two annual excise tax increases from 2012 to 2014. Smokers from New Zealand cities completed questionnaires at three time points before and after two excise tax increases. There were no significant differences in cigarettes per day or psychological addiction at baseline, but a linear decline in both measures was observed in Māori/Pacific and NZ European smokers. Cigarettes per day reduced at a greater rate for Māori/Pacific than NZ European smokers but dependence did not. Results indicated that Māori/Pacific smokers' demand for cigarettes may be more price sensitive than NZ European smokers. Implications for Public Health: Tobacco excise tax may be particularly effective for Māori/Pacific smokers and may contribute to reductions in smoking-related health inequalities in NZ. © 2016 The Authors.

42 CFR 93.217 - Office of Research Integrity or ORI.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Office of Research Integrity or ORI. 93.217 Section 93.217 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE...

Inhibition of Bacillus cereus Strains by Antimicrobial Metabolites from Lactobacillus johnsonii CRL1647 and Enterococcus faecium SM21.

PubMed

Soria, M Cecilia; Audisio, M Carina

2014-12-01

Bacillus cereus is an endospore-forming, Gram-positive bacterium able to cause foodborne diseases. Lactic acid bacteria (LAB) are known for their ability to synthesize organic acids and bacteriocins, but the potential of these compounds against B. cereus has been scarcely documented in food models. The present study has examined the effect of the metabolites produced by Lactobacillus johnsonii CRL1647 and Enterococcus faecium SM21 on the viability of select B. cereus strains. Furthermore, the effect of E. faecium SM21 metabolites against B. cereus strains has also been investigated on a rice food model. L. johnsonii CRL1647 produced 128 mmol/L of lactic acid, 38 mmol/L of acetic acid and 0.3 mmol/L of phenyl-lactic acid. These organic acids reduced the number of vegetative cells and spores of the B. cereus strains tested. However, the antagonistic effect disappeared at pH 6.5. On the other hand, E. faecium SM21 produced only lactic and acetic acid (24.5 and 12.2 mmol/L, respectively) and was able to inhibit both vegetative cells and spores of the B. cereus strains, at a final fermentation pH of 5.0 and at pH 6.5. This would indicate the action of other metabolites, different from organic acids, present in the cell-free supernatant. On cooked rice grains, the E. faecium SM21 bacteriocin(s) were tested against two B. cereus strains. Both of them were significantly affected within the first 4 h of contact; whereas B. cereus BAC1 cells recovered after 24 h, the effect on B. cereus 1 remained up to the end of the assay. The LAB studied may thus be considered to define future strategies for biological control of B. cereus.

X-ray, UV and optical analysis of supergiants: ɛ Ori

NASA Astrophysics Data System (ADS)

Puebla, Raul E.; Hillier, D. John; Zsargó, Janos; Cohen, David H.; Leutenegger, Maurice A.

2016-03-01

We present a multi-wavelength (X-ray to optical) analysis, based on non-local thermodynamic equilibrium photospheric+wind models, of the B0 Ia-supergiant: ɛ Ori. The aim is to test the consistency of physical parameters, such as the mass-loss rate and CNO abundances, derived from different spectral bands. The derived mass-loss rate is {dot {M}} / {√{f_{∞}}} {˜} 1.6 × 10-6 M⊙ yr-1 where f∞ is the volume filling factor. However, the S IV λλ1062,1073 profiles are too strong in the models; to fit the observed profiles it is necessary to use f∞ <0.01. This value is a factor of 5 to 10 lower than inferred from other diagnostics, and implies {dot{M}} ≲ 1 × 10^{-7} M⊙ yr-1. The discrepancy could be related to porosity-vorosity effects or a problem with the ionization of sulphur in the wind. To fit the UV profiles of N V and O VI it was necessary to include emission from an interclump medium with a density contrast (ρcl/ρICM) of ˜100. X-ray emission in H/He like and Fe L lines was modelled using four plasma components located within the wind. We derive plasma temperatures from 1 × 106 to 7 × 106 K, with lower temperatures starting in the outer regions (R0 ˜ 3-6 R*), and a hot component starting closer to the star (R0 ≲ 2.9 R*). From X-ray line profiles we infer {dot{M}} < 4.9 × 10-7 M⊙ yr-1. The X-ray spectrum (≥0.1 kev) yields an X-ray luminosity LX ˜ 2.0 × 10-7Lbol, consistent with the superion line profiles. X-ray abundances are in agreement with those derived from the UV and optical analysis: ɛ Ori is slightly enhanced in nitrogen and depleted in carbon and oxygen, evidence for CNO processed material.

A contracting circumbinary molecular ring around Ori 139-409 with an inner cavity of about 140 au

NASA Astrophysics Data System (ADS)

Zapata, Luis A.; Schilke, Peter; Ho, Paul T. P.

2010-03-01

We present sensitive and subarcsecond resolution (~0.7 arcsec) CH3OH(7-2,6-6-2,5) line and 890-μm continuum observations, made with the Submillimeter Array (SMA), towards the hot molecular circumbinary ring associated with the young multiple star Ori 139-409. The CH3OH(7-2,6-6-2,5) emission from the ring is well resolved at this angular resolution, revealing an inner cavity with a size of about 140 au. A local thermodynamic equilibrium model of a Keplerian disc with an inner cavity of the same size confirms the presence of this cavity. Additionally, this model suggests that the circumbinary ring is contracting with a velocity of Vinf ~ 1.5kms-1 towards the binary central compact circumstellar discs reported at a wavelength of 7 mm. The inner central cavity seems to be formed by the tidal effects of the young stars in the middle of the ring. The ring does not appear to be a stationary object. Furthermore, the infall velocity we determine is about a factor of 3 slower than the free-fall velocity corresponding to the dynamical mass. This would correspond to a mass accretion rate of about 10-5 Msolar yr-1. We have found that the dust emission associated with Ori 139-409 appears to be arising from the circumstellar discs, with no strong contribution from the molecular gas ring. Furthermore, a simple comparison with other classical molecular dusty rings (e.g. GG Tau, UZ Tau and UY Aur) suggests that Ori 139-409 could be one of the youngest circumbinary rings reported to date. Finally, our results confirm that the circumbinary rings are actively funnelling fresh gas material to the central compact binary circumstellar discs (i.e. to the protostars in the very early phases of their evolution).

"I Want to Walk with My Moko." The Application of Social Cognitive Theory in the Creation of a Diabetes Prevention Documentary with New Zealand Māori.

PubMed

Farmer, Alison; Edgar, Timothy; Gage, Jeffrey; Kirk, Ray

2018-01-01

Type 2 diabetes is almost three times more prevalent in the indigenous people of New Zealand (Māori) than non-Māori. Despite the high rate of diabetes there is a low level of diabetes knowledge and awareness in the Māori community. Several studies of Māori health identify a need for new health communication approaches to diabetes prevention in order to reduce the gap between Māori and non-Māori disease rates. We applied a Community-Based Participatory Research (CBPR) framework and behavioral theory to create a culturally appropriate documentary for Māori at risk for type 2 diabetes. We discuss how we utilized Bandura's social cognitive theory to provide a culturally sensitive theoretical basis for behavior change messaging. We outline why social cognitive theory was a culturally appropriate foundation and describe the role of the community in shaping the documentary messaging. A culture-centered approach utilizing participatory methodologies and culturally sensitive behavioral change theory might serve as a model for creating health communication resources in collaboration with other indigenous communities.

Role for a region of helically unstable DNA within the Epstein-Barr virus latent cycle origin of DNA replication oriP in origin function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Polonskaya, Zhanna; Benham, Craig J.; Hearing, Janet

The minimal replicator of the Epstein-Barr virus (EBV) latent cycle origin of DNA replication oriP is composed of two binding sites for the Epstein-Barr virus nuclear antigen-1 (EBNA-1) and flanking inverted repeats that bind the telomere repeat binding factor TRF2. Although not required for minimal replicator activity, additional binding sites for EBNA-1 and TRF2 and one or more auxiliary elements located to the right of the EBNA-1/TRF2 sites are required for the efficient replication of oriP plasmids. Another region of oriP that is predicted to be destabilized by DNA supercoiling is shown here to be an important functional component ofmore » oriP. The ability of DNA fragments of unrelated sequence and possessing supercoiled-induced DNA duplex destabilized (SIDD) structures, but not fragments characterized by helically stable DNA, to substitute for this component of oriP demonstrates a role for the SIDD region in the initiation of oriP-plasmid DNA replication.« less

42 CFR 93.217 - Office of Research Integrity or ORI.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Office of Research Integrity or ORI. 93.217 Section 93.217 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Definitions §...

Effect of Expiratory Resistive Loading in Expiratory Muscle Strength Training on Orbicularis Oris Muscle Activity

PubMed Central

Yanagisawa, Yukio; Matsuo, Yoshimi; Shuntoh, Hisato; Horiuchi, Noriaki

2014-01-01

[Purpose] The purpose of this study was to elucidate the effect of expiratory resistive loading on orbicularis oris muscle activity. [Subjects] Subjects were 23 healthy individuals (11 males, mean age 25.5±4.3 years; 12 females, mean age 25.0±3.0 years). [Methods] Surface electromyography was performed to measure the activity of the orbicularis oris muscle during maximum lip closure and resistive loading at different expiratory pressures. Measurement was performed at 10%, 30%, 50%, and 100% of maximum expiratory pressure (MEP) for all subjects. The t-test was used to compare muscle activity between maximum lip closure and 100% MEP, and analysis of variance followed by multiple comparisons was used to compare the muscle activities observed at different expiratory pressures. [Results] No significant difference in muscle activity was observed between maximum lip closure and 100% MEP. Analysis of variance with multiple comparisons revealed significant differences among the different expiratory pressures. [Conclusion] Orbicularis oris muscle activity increased with increasing expiratory resistive loading. PMID:24648644

Application of MLST and Pilus Gene Sequence Comparisons to Investigate the Population Structures of Actinomyces naeslundii and Actinomyces oris

PubMed Central

Henssge, Uta; Do, Thuy; Gilbert, Steven C.; Cox, Steven; Clark, Douglas; Wickström, Claes; Ligtenberg, A. J. M.; Radford, David R.; Beighton, David

2011-01-01

Actinomyces naeslundii and Actinomyces oris are members of the oral biofilm. Their identification using 16S rRNA sequencing is problematic and better achieved by comparison of metG partial sequences. A. oris is more abundant and more frequently isolated than A. naeslundii. We used a multi-locus sequence typing approach to investigate the genotypic diversity of these species and assigned A. naeslundii (n = 37) and A. oris (n = 68) isolates to 32 and 68 sequence types (ST), respectively. Neighbor-joining and ClonalFrame dendrograms derived from the concatenated partial sequences of 7 house-keeping genes identified at least 4 significant subclusters within A. oris and 3 within A. naeslundii. The strain collection we had investigated was an under-representation of the total population since at least 3 STs composed of single strains may represent discrete clusters of strains not well represented in the collection. The integrity of these sub-clusters was supported by the sequence analysis of fimP and fimA, genes coding for the type 1 and 2 fimbriae, respectively. An A. naeslundii subcluster was identified with both fimA and fimP genes and these strains were able to bind to MUC7 and statherin while all other A. naeslundii strains possessed only fimA and did not bind to statherin. An A. oris subcluster harboured a fimA gene similar to that of Actinomyces odontolyticus but no detectable fimP failed to bind significantly to either MUC7 or statherin. These data are evidence of extensive genotypic and phenotypic diversity within the species A. oris and A. naeslundii but the status of the subclusters identified here will require genome comparisons before their phylogenic position can be unequivocally established. PMID:21738661

Application of MLST and pilus gene sequence comparisons to investigate the population structures of Actinomyces naeslundii and Actinomyces oris.

PubMed

Henssge, Uta; Do, Thuy; Gilbert, Steven C; Cox, Steven; Clark, Douglas; Wickström, Claes; Ligtenberg, A J M; Radford, David R; Beighton, David

2011-01-01

Actinomyces naeslundii and Actinomyces oris are members of the oral biofilm. Their identification using 16S rRNA sequencing is problematic and better achieved by comparison of metG partial sequences. A. oris is more abundant and more frequently isolated than A. naeslundii. We used a multi-locus sequence typing approach to investigate the genotypic diversity of these species and assigned A. naeslundii (n = 37) and A. oris (n = 68) isolates to 32 and 68 sequence types (ST), respectively. Neighbor-joining and ClonalFrame dendrograms derived from the concatenated partial sequences of 7 house-keeping genes identified at least 4 significant subclusters within A. oris and 3 within A. naeslundii. The strain collection we had investigated was an under-representation of the total population since at least 3 STs composed of single strains may represent discrete clusters of strains not well represented in the collection. The integrity of these sub-clusters was supported by the sequence analysis of fimP and fimA, genes coding for the type 1 and 2 fimbriae, respectively. An A. naeslundii subcluster was identified with both fimA and fimP genes and these strains were able to bind to MUC7 and statherin while all other A. naeslundii strains possessed only fimA and did not bind to statherin. An A. oris subcluster harboured a fimA gene similar to that of Actinomyces odontolyticus but no detectable fimP failed to bind significantly to either MUC7 or statherin. These data are evidence of extensive genotypic and phenotypic diversity within the species A. oris and A. naeslundii but the status of the subclusters identified here will require genome comparisons before their phylogenic position can be unequivocally established.

Āwhina Revolution: A Bayesian Analysis of Undergraduate and Postgraduate Completion Rates from a Program for Māori and Pacific Success in STEM Disciplines.

PubMed

Richardson, Ken; Clark, Zaramasina; Gaines, Michael; Kingi, Hautahi; Miller, Sonja; Pearson, Willie; Richardson, Liz

2018-01-01

Māori and Pacific students generally do not attain the same levels of tertiary success as New Zealanders of European descent, particularly in science, technology, engineering, and mathematics (STEM) subjects. Te Rōpū Āwhina (Āwhina), an equity initiative at Victoria University of Wellington in New Zealand between 1999 and 2015, aimed to produce Māori and Pacific professionals in STEM disciplines who contribute to Māori and Pacific community development and leadership. A hierarchical Bayesian approach was used to estimate posterior standardized completion rates for 3-year undergraduate and 2-year postgraduate degrees undertaken by non-Māori-Pacific and Māori-Pacific students. Results were consistent with an Āwhina effect, that is, Āwhina's positive influence on (combined) Māori and Pacific success. © 2018 K. Richardson et al. CBE—Life Sciences Education © 2018 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Evoked electromyography to rocuronium in orbicularis oris and gastrocnemius in facial nerve injury in rabbits.

PubMed

Xing, Yian; Chen, Lianhua; Li, Shitong

2013-11-01

Muscles innervated by the facial nerve show different sensitivities to muscle relaxants than muscles innervated by somatic nerves, especially in the presence of facial nerve injury. We compared the evoked electromyography (EEMG) response of orbicularis oris and gastrocnemius in with and without a non-depolarizing muscle relaxant in a rabbit model of graded facial nerve injury. Differences in EEMG response and inhibition by rocuronium were measured in the orbicularis oris and gastrocnemius muscles 7 to 42 d after different levels of facial nerve crush injuries in adult rabbits. Baseline EEMG of orbicularis oris was significantly smaller than those of the gastrocnemius. Gastrocnemius was more sensitive to rocuronium than the facial muscles (P < 0.05). Baseline EEMG and EEMG amplitude of orbicularis oris in the presence of rocuronium was negatively correlated with the magnitude of facial nerve injury but the sensitivity to rocuronium was not. No significant difference was found in the onset time and the recovery time of rocuronium among gastrocnemius and normal or damaged facial muscles. Muscles innervated by somatic nerves are more sensitive to rocuronium than those innervated by the facial nerve, but while facial nerve injury reduced EEMG responses, the sensitivity to rocuronium is not altered. Partial neuromuscular blockade may be a suitable technique for conducting anesthesia and surgery safely when EEMG monitoring is needed to preserve and protect the facial nerve. Additional caution should be used if there is a risk of preexisting facial nerve injury. Copyright © 2013 Elsevier Inc. All rights reserved.

Reoxidation of the Thiol-Disulfide Oxidoreductase MdbA by a Bacterial Vitamin K Epoxide Reductase in the Biofilm-Forming Actinobacterium Actinomyces oris.

PubMed

Luong, Truc Thanh; Reardon-Robinson, Melissa E; Siegel, Sara D; Ton-That, Hung

2017-05-15

Posttranslocational protein folding in the Gram-positive biofilm-forming actinobacterium Actinomyces oris is mediated by a membrane-bound thiol-disulfide oxidoreductase named MdbA, which catalyzes oxidative folding of nascent polypeptides transported by the Sec translocon. Reoxidation of MdbA involves a bacterial v itamin K ep o xide r eductase (VKOR)-like protein that contains four cysteine residues, C93/C101 and C175/C178, with the latter forming a canonical CXXC thioredoxin-like motif; however, the mechanism of VKOR-mediated reoxidation of MdbA is not known. We present here a topological view of the A. oris membrane-spanning protein VKOR with these four exoplasmic cysteine residues that participate in MdbA reoxidation. Like deletion of the VKOR gene, alanine replacement of individual cysteine residues abrogated polymicrobial interactions and biofilm formation, concomitant with the failure to form adhesive pili on the bacterial surface. Intriguingly, the mutation of the cysteine at position 101 to alanine (C101A mutation) resulted in a high-molecular-weight complex that was positive for MdbA and VKOR by immunoblotting and was absent in other alanine substitution mutants and the C93A C101A double mutation and after treatment with the reducing agent β-mercaptoethanol. Consistent with this observation, affinity purification followed by immunoblotting confirmed this MdbA-VKOR complex in the C101A mutant. Furthermore, ectopic expression of the Mycobacterium tuberculosis VKOR analog in the A. oris VKOR deletion (ΔVKOR) mutant rescued its defects, in contrast to the expression of M. tuberculosis VKOR variants known to be nonfunctional in the disulfide relay that mediates reoxidation of the disulfide bond-forming catalyst DsbA in Escherichia coli Altogether, the results support a model of a disulfide relay, from its start with the pair C93/C101 to the C175-X-X-C178 motif, that is required for MdbA reoxidation and appears to be conserved in members of the class

Fabrication, characterization, and heuristic trade space exploration of magnetically actuated Miura-Ori origami structures

NASA Astrophysics Data System (ADS)

Cowan, Brett; von Lockette, Paris R.

2017-04-01

The authors develop magnetically actuated Miura-Ori structures through observation, experiment, and computation using an initially heuristic strategy followed by trade space visualization and optimization. The work is novel, especially within origami engineering, in that beyond final target shape approximation, Miura-Ori structures in this work are additionally evaluated for the shape approximation while folding and for their efficient use of their embedded actuators. The structures consisted of neodymium magnets placed on the panels of silicone elastomer substrates cast in the Miura-Ori folding pattern. Initially four configurations, arrangements of magnets on the panels, were selected based on heuristic arguments that (1) maximized the amount of magnetic torque applied to the creases and (2) reduced the number of magnets needed to affect all creases in the pattern. The results of experimental and computational performance metrics were used in a weighted sum model to predict the optimum configuration, which was then fabricated and experimentally characterized for comparison to the initial prototypes. As expected, optimization of magnet placement and orientation was effective at increasing the degree of theoretical useful work. Somewhat unexpectedly, however, trade space results showed that even after optimization, the configuration with the most number of magnets was least effective, per magnet, at directing its actuation to the structure’s creases. Overall, though the winning configuration experimentally outperformed its initial, non-optimal counterparts, results showed that the choice of optimum configuration was heavily dependent on the weighting factors. These results highlight both the ability of the Miura-Ori to be actuated with external magnetic stimuli, the effectiveness of a heuristic design approach that focuses on the actuation mechanism, and the need to address path-dependent metrics in assessing performance in origami folding structures.

A qualitative analysis of Māori and Pacific smokers' views on informed choice and smoking

PubMed Central

Gifford, Heather; Tautolo, El-Shadan; Erick, Stephanie; Hoek, Janet; Gray, Rebecca; Edwards, Richard

2016-01-01

Objectives Tobacco companies frame smoking as an informed choice, a strategy that holds individuals responsible for harms they incur. Few studies have tested this argument, and even fewer have examined how informed indigenous smokers or those from minority ethnicities are when they start smoking. We explored how young adult Māori and Pacific smokers interpreted ‘informed choice’ in relation to smoking. Participants Using recruitment via advertising, existing networks and word of mouth, we recruited and undertook qualitative in-depth interviews with 20 Māori and Pacific young adults aged 18–26 years who smoked. Analyses Data were analysed using an informed-choice framework developed by Chapman and Liberman. We used a thematic analysis approach to identify themes that extended this framework. Results Few participants considered themselves well informed and none met more than the framework's initial two criteria. Most reflected on their unthinking uptake and subsequent addiction, and identified environmental factors that had facilitated uptake. Nonetheless, despite this context, most agreed that they had made an informed choice to smoke. Conclusions The discrepancy between participants' reported knowledge and understanding of smoking's risks, and their assessment of smoking as an informed choice, reflects their view of smoking as a symbol of adulthood. Policies that make tobacco more difficult to use in social settings could help change social norms around smoking and the ease with which initiation and addiction currently occur. PMID:27188813

Din7 and Mhr1 expression levels regulate double-strand-break–induced replication and recombination of mtDNA at ori5 in yeast

PubMed Central

Ling, Feng; Hori, Akiko; Yoshitani, Ayako; Niu, Rong; Yoshida, Minoru; Shibata, Takehiko

2013-01-01

The Ntg1 and Mhr1 proteins initiate rolling-circle mitochondrial (mt) DNA replication to achieve homoplasmy, and they also induce homologous recombination to maintain mitochondrial genome integrity. Although replication and recombination profoundly influence mitochondrial inheritance, the regulatory mechanisms that determine the choice between these pathways remain unknown. In Saccharomyces cerevisiae, double-strand breaks (DSBs) introduced by Ntg1 at the mitochondrial replication origin ori5 induce homologous DNA pairing by Mhr1, and reactive oxygen species (ROS) enhance production of DSBs. Here, we show that a mitochondrial nuclease encoded by the nuclear gene DIN7 (DNA damage inducible gene) has 5′-exodeoxyribonuclease activity. Using a small ρ− mtDNA bearing ori5 (hypersuppressive; HS) as a model mtDNA, we revealed that DIN7 is required for ROS-enhanced mtDNA replication and recombination that are both induced at ori5. Din7 overproduction enhanced Mhr1-dependent mtDNA replication and increased the number of residual DSBs at ori5 in HS-ρ− cells and increased deletion mutagenesis at the ori5 region in ρ+ cells. However, simultaneous overproduction of Mhr1 suppressed all of these phenotypes and enhanced homologous recombination. Our results suggest that after homologous pairing, the relative activity levels of Din7 and Mhr1 modulate the preference for replication versus homologous recombination to repair DSBs at ori5. PMID:23598996

Din7 and Mhr1 expression levels regulate double-strand-break-induced replication and recombination of mtDNA at ori5 in yeast.

PubMed

Ling, Feng; Hori, Akiko; Yoshitani, Ayako; Niu, Rong; Yoshida, Minoru; Shibata, Takehiko

2013-06-01

The Ntg1 and Mhr1 proteins initiate rolling-circle mitochondrial (mt) DNA replication to achieve homoplasmy, and they also induce homologous recombination to maintain mitochondrial genome integrity. Although replication and recombination profoundly influence mitochondrial inheritance, the regulatory mechanisms that determine the choice between these pathways remain unknown. In Saccharomyces cerevisiae, double-strand breaks (DSBs) introduced by Ntg1 at the mitochondrial replication origin ori5 induce homologous DNA pairing by Mhr1, and reactive oxygen species (ROS) enhance production of DSBs. Here, we show that a mitochondrial nuclease encoded by the nuclear gene DIN7 (DNA damage inducible gene) has 5'-exodeoxyribonuclease activity. Using a small ρ(-) mtDNA bearing ori5 (hypersuppressive; HS) as a model mtDNA, we revealed that DIN7 is required for ROS-enhanced mtDNA replication and recombination that are both induced at ori5. Din7 overproduction enhanced Mhr1-dependent mtDNA replication and increased the number of residual DSBs at ori5 in HS-ρ(-) cells and increased deletion mutagenesis at the ori5 region in ρ(+) cells. However, simultaneous overproduction of Mhr1 suppressed all of these phenotypes and enhanced homologous recombination. Our results suggest that after homologous pairing, the relative activity levels of Din7 and Mhr1 modulate the preference for replication versus homologous recombination to repair DSBs at ori5.

KIR Diversity in Māori and Polynesians: Populations in which HLA-B is not a Significant KIR Ligand

PubMed Central

Nemat-Gorgani, Neda; Edinur, Hisham A.; Hollenbach, Jill A.; Traherne, James A.; Dunn, Paul P. J.; Chambers, Geoffrey K.; Parham, Peter; Norman, Paul J.

2014-01-01

HLA class I molecules and killer cell immunoglobulin-like receptors (KIR) form a diverse system of ligands and receptors that individualize human immune systems in ways that improve the survival of individuals and populations. Human settlement of Oceania by island-hopping East and Southeast Asian migrants started ~3,500 years ago. Subsequently, New Zealand was reached ~750 years ago by ancestral Māori. To examine how this history impacted KIR and HLA diversity, and their functional interaction, we defined at high resolution the allelic and haplotype diversity of the 13 expressed KIR genes in 49 Māori and 34 Polynesians. Eighty KIR variants, including four ‘new’ alleles, were defined; as were 35 centromeric and 22 telomeric KIR region haplotypes, which combine to give >50 full-length KIR haplotypes. Two new and divergent variant KIR form part of a telomeric KIR haplotype, which appears derived from Papua New Guinea and was probably obtained by the Asian migrants en route to Polynesia. Māori and Polynesian KIR are very similar, but differ significantly from African, European, Japanese and Amerindian KIR. Māori and Polynesians have high KIR haplotype diversity with corresponding allotype diversity being maintained throughout the KIR locus. Within the population each individual has a unique combination of HLA class I and KIR. Characterizing Māori and Polynesians is a paucity of HLA-B allotypes recognized by KIR. Compensating for this deficiency are high frequencies (>50%) of HLA-A allotypes recognized by KIR. These HLA-A allotypes are ones that modern humans likely acquired from archaic humans at a much earlier time. PMID:25139336

Young stellar objects & photoevaporating protoplanetary disks in the Orion's sibling NGC 1977.

NASA Astrophysics Data System (ADS)

Kim, J. S.; Fang, M.; Clarke, C. J.; Facchini, S.; Pascucci, I.; Apai, D.; Bally, J.

We present young stellar population in NGC 1977, Orion Nebula's sibling, and the discovery of new photoevaporating protoplanetary disks (proplyds) around a B star, 42 Ori. NGC 1977 (age≲2 Myr) is located at ˜30arcmin north of the Orion Nebula at a distance of ˜400 pc, but it lacks high mass O stars unlike in Orion Nebula Cluster (ONC). Nevertheless, we have identified seven proplyds in vicinity of its most massive star, 42 Ori (B1V). The proplyds show cometary Halpha emission in HST images, with clear ionization front and tails evaporating away from 42 Ori. These are the first proplyds to be found around a B star, while previously known proplyds were found near O stars. The FUV radiation impinging on these proplyds is 10-30 times weaker than that on the proplyds in ONC. We find that observed proplyd sizes are consistent with a model for photoevaporation in weak FUV radiation field. We briefly discuss one of the interesting YSOs found in this lesser-known star forming region in Orion, NGC 1977.

42 CFR 93.315 - Notice to ORI of institutional findings and actions.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Final institutional action. State whether the institution found research misconduct, and if so, who... 42 Public Health 1 2011-10-01 2011-10-01 false Notice to ORI of institutional findings and actions... HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of Institutions The Institutional...

42 CFR 93.315 - Notice to ORI of institutional findings and actions.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Final institutional action. State whether the institution found research misconduct, and if so, who... 42 Public Health 1 2010-10-01 2010-10-01 false Notice to ORI of institutional findings and actions... HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of Institutions The Institutional...

DETECTION OF A COOL, ACCRETION-SHOCK-GENERATED X-RAY PLASMA IN EX LUPI DURING THE 2008 OPTICAL ERUPTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teets, William K.; Weintraub, David A.; Kastner, Joel H.

2012-11-20

EX Lupi is the prototype for a class of young, pre-main-sequence stars which are observed to undergo irregular, presumably accretion-generated, optical outbursts that result in a several magnitude rise of the optical flux. EX Lupi was observed to optically erupt in 2008 January, triggering Chandra ACIS Target of Opportunity observations shortly thereafter. We find very strong evidence that most of the X-ray emission in the first few months after the optical outburst is generated by accretion of circumstellar material onto the stellar photosphere. Specifically, we find a strong correlation between the decreasing optical and X-ray fluxes following the peak ofmore » the outburst in the optical, which suggests that these observed declines in both the optical and X-ray fluxes are the result of declining accretion rate. In addition, in our models of the X-ray spectrum, we find strong evidence for a {approx}0.4 keV plasma component, as expected for accretion shocks on low-mass, pre-main-sequence stars. From 2008 March through October, this cool plasma component appeared to fade as EX Lupi returned to its quiescent level in the optical, consistent with a decrease in the overall emission measure of accretion-shock-generated plasma. The overall small increase of the X-ray flux during the optical outburst of EX Lupi is similar to what was observed in previous X-ray observations of the 2005 optical outburst of the EX Lupi-type star V1118 Ori but contrasts with the large increase of the X-ray flux from the erupting young star V1647 Ori during its 2003 and 2008 optical outbursts.« less

Detection of a Cool, Accretion-Shock-Generated X-Ray Plasma in EX Lupi During the 2008 Optical Eruption

NASA Technical Reports Server (NTRS)

Teets, William K.; Weintraub, David A.; Kastner, Joel H.; Grosso, Nicholas; Hamaguchi, Kenji; Richmond, Michael

2012-01-01

EX Lupi is the prototype for a class of young, pre-main-sequence stars which are observed to undergo irregular, presumably accretion-generated, optical outbursts that result in a several magnitude rise of the optical flux. EX Lupi was observed to optically erupt in 2008 January, triggering Chandra ACIS Target of Opportunity observations shortly thereafter. We find very strong evidence that most of the X-ray emission in the first few months after the optical outburst is generated by accretion of circumstellar material onto the stellar photosphere. Specifically, we find a strong correlation between the decreasing optical and X-ray fluxes following the peak of the outburst in the optical, which suggests that these observed declines in both the optical and X-ray fluxes are the result of declining accretion rate. In addition, in our models of the X-ray spectrum, we find strong evidence for an approx 0.4 keV plasma component, as expected for accretion shocks on low-mass, pre-main-sequence stars. From 2008 March through October, this cool plasma component appeared to fade as EX Lupi returned to its quiescent level in the optical, consistent with a decrease in the overall emission measure of accretion-shock-generated plasma. The overall small increase of the X-ray flux during the optical outburst of EX Lupi is similar to what was observed in previous X-ray observations of the 2005 optical outburst of the EX Lupi-type star V1118 Ori but contrasts with the large increase of the X-ray flux from the erupting young star V1647 Ori during its 2003 and 2008 optical outbursts.

Toward an Objective Enhanced-V Detection Algorithm

NASA Technical Reports Server (NTRS)

Moses, John F.; Brunner,Jason C.; Feltz, Wayne F.; Ackerman, Steven A.; Moses, John F.; Rabin, Robert M.

2007-01-01

The area of coldest cloud tops above thunderstorms sometimes has a distinct V or U shape. This pattern, often referred to as an "enhanced-V signature, has been observed to occur during and preceding severe weather. This study describes an algorithmic approach to objectively detect overshooting tops, temperature couplets, and enhanced-V features with observations from the Geostationary Operational Environmental Satellite and Low Earth Orbit data. The methodology consists of temperature, temperature difference, and distance thresholds for the overshooting top and temperature couplet detection parts of the algorithm and consists of cross correlation statistics of pixels for the enhanced-V detection part of the algorithm. The effectiveness of the overshooting top and temperature couplet detection components of the algorithm is examined using GOES and MODIS image data for case studies in the 2003-2006 seasons. The main goal is for the algorithm to be useful for operations with future sensors, such as GOES-R.

High incidence of medulloblastoma in Māori and Pacific populations in New Zealand.

PubMed

Elwood, J Mark; Aye, Phyu Sin

2017-02-17

In New Zealand from 1995-2010, the incidence of medulloblastoma at ages 1-19 years was significantly higher in Māori (relative risk 2.0) and in Pacific peoples (RR 2.1) than in New Zealand Europeans.

Ethnic density and area deprivation: neighbourhood effects on Māori health and racial discrimination in Aotearoa/New Zealand.

PubMed

Bécares, Laia; Cormack, Donna; Harris, Ricci

2013-07-01

Some studies suggest that ethnic minority people are healthier when they live in areas with a higher concentration of people from their own ethnic group, a so-called ethnic density effect. To date, no studies have examined the ethnic density effect among indigenous peoples, for whom connections to land, patterns of settlement, and drivers of residential location may differ from ethnic minority populations. The present study analysed the Māori sample from the 2006/07 New Zealand Health Survey to examine the association between increased Māori ethnic density, area deprivation, health, and experiences of racial discrimination. Results of multilevel regressions showed that an increase in Māori ethnic density was associated with decreased odds of reporting poor self-rated health, doctor-diagnosed common mental disorders, and experienced racial discrimination. These associations were strengthened after adjusting for area deprivation, which was consistently associated with increased odds of reporting poor health and reports of racial discrimination. Our findings show that whereas ethnic density is protective of the health and exposure to racial discrimination of Māori, this effect is concealed by the detrimental effect of area deprivation, signalling that the benefits of ethnic density must be interpreted within the current socio-political context. This includes the institutional structures and racist practices that have created existing health and socioeconomic inequities in the first place, and maintain the unequal distribution of concentrated poverty in areas of high Māori density. Addressing poverty and the inequitable distribution of socioeconomic resources by ethnicity and place in New Zealand is vital to improving health and reducing inequalities. Given the racialised nature of access to goods, services, and opportunities within New Zealand society, this also requires a strong commitment to eliminating racism. Such commitment and action will allow the benefits

A chimeric protein composed of NuMA fused to the DNA binding domain of LANA is sufficient for the ori-P-dependent DNA replication

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ohsaki, Eriko; Ueda, Keiji, E-mail: kueda@virus.me

The Kaposi's sarcoma-associated herpesvirus (KSHV) genome is stably maintained in KSHV-infected PEL cell lines during cell division. We previously showed that accumulation of LANA in the nuclear matrix fraction could be important for the latent DNA replication, and that the functional significance of LANA should be its recruitment of ori-P to the nuclear matrix. Here, we investigated whether the forced localization of the LANA-DNA binding domain (DBD) to the nuclear matrix facilitated ori-P-containing plasmid replication. We demonstrated that chimeric proteins constructed by fusion of LANA DBD with the nuclear mitotic apparatus protein (NuMA), which is one of the components ofmore » the nuclear matrix, could bind with ori-P and enhance replication of an ori-P-containing plasmid, compared with that in the presence of DBD alone. These results further suggested that the ori-P recruitment to the nuclear matrix through the binding with DBD is important for latent viral DNA replication. - Highlights: •KSHV replication in latency depends on LANA localization to the nuclear matrix. •LANA DBD was fused with NuMA, a nuclear matrix protein, at the N- and C-terminus. •NuMA-DBD was in the nuclear matrix and supported the ori-P dependent replication. •LANA in the nuclear matrix should be important for the KSHV replication in latency.« less

The protective influence of family connectedness, ethnic identity, and ethnic engagement for New Zealand Ma̅ori adolescents.

PubMed

Stuart, Jaimee; Jose, Paul E

2014-06-01

The present study examined the associations among family connectedness, ethnic identity, and ethnic engagement on changes in well-being over time for the understudied population of Ma̅ori (indigenous New Zealand) youth. Data were collected as part of a longitudinal study of youth connectedness in New Zealand using self-report measures at 3 measurement occasions separated by 1 year each. Participants in the current study were 431 self-identified Ma̅ori (ages 10-15 years at Time 1). As expected, the variables of family connectedness, ethnic identity, and well-being were all positively related to each other. Results of a latent growth curve model showed that, following normative trends for adolescents of this age, well-being diminished over time for Ma̅ori youth; however, high levels of family connectedness were found to mitigate this general decline in well-being over time. Furthermore, in a longitudinal path analysis, ethnic engagement was found to exert a positive indirect effect on residualized Time 3 well-being through Time 2 ethnic identity. These findings indicate that the quality of family relationships and affiliation with one's ethnic group are important predictors of positive adjustment for Ma̅ori youth over time. These results are discussed in the context of positive youth development for ethnic minority and indigenous youth. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Whakaora nga moemoea o nga tupuna--living the dreams of the ancestors. Future planning in a Kaupapa Māori CAMHS team.

PubMed

Elder, Hinemoa; Milne, Moe; Witehira, Heemi; Mendes, Patrick; Heslin, Anneliese; Cribb-Su'a, Ainsleigh; Wilson, Riwai; Goldsmith, Arona; Kainamu, Reena; Barrett, Moana; Love, Shar; Cargo, Tania; Kalra, Vanitha

2009-08-01

The aim of this study was to identify and operationalize aspects of a future planning process for sustainable delivery of Kaupapa Māori (Specialist Māori) mental health from a team called He Kakano, within Child and Adolescent Mental Health Services in South Auckland, New Zealand. A 2-day hui (meeting) was held with members of the team and a facilitator, Whaea Moe Milne. Review of background national epidemiological data, local data, information from community, carer and tangata whaiora (consumer) stakeholders and the existing He Kakano Model of Care was undertaken. Use of tikanga (Māori protocol and practices) was evident throughout the hui. A number of aspects of tikanga were identified as essential to the positive outcomes of the future plan. This paper reports one in particular, that of whakatauakī (proverbs where the originator is known). "Whakaora nga moemoea o nga tupuna--living the dreams of the ancestors" is a whakatauakī articulated by Whaea Moe Milne, which was identified as helpful in influencing the strategic planning thinking and decision-making process for He Kakano. This whakatauakī enabled the identification of shared goals, values, beliefs, behaviours and an action plan. The existing and ongoing relationship with Whaea Moe Milne was identified as an important element in the way in which the whakatauakī was received and reflected on. Use of tikanga Māori, in this case, whakatauakī, was helpful in developing future planning for He Kakano. This suggests that use of tikanga may be beneficial in other settings where planning for sustainable Māori responsive services is undertaken. Further work in this area is likely to benefit service development, strategic planning, workforce development and have an impact on improving health outcomes for Māori.

VizieR Online Data Catalog: 25 Ori group low-mass stars (Downes+, 2014)

NASA Astrophysics Data System (ADS)

Downes, J. J.; Briceno, C.; Mateu, C.; Hernandez, J.; Vivas, A. K.; Calvet, N.; Hartmann, L.; Petr-Gotzens, M. G.; Allen, L.

2015-04-01

Multi-epoch optical V-, R-, I-band and Hα observations across the entire Orion OB1 association (spanning ~180deg2) were obtained as part of the CVSO (Briceno et al., 2005AJ....129..907B, Cat. J/AJ/129/907), being conducted since 1998 with the Jurgen Stock 1.0/1.5 Schmidt-type telescope and the 8000x8000-pixel QUEST-I CCD Mosaic camera, at the National Astronomical Observatory of Venezuela. During 2009 a new dedicated 4m survey telescope, the Visible and Infrared Survey Telescope for Astronomy (VISTA), located at ESO's Paranal Observatory, was commissioned by the VISTA consortium. For the Galactic Science Verification of VISTA, an ~30deg2 area of the Orion OB1 association, which included the Orion Belt region, part of the Orion A cloud, the 25 Orionis and σ Ori clusters, was imaged in the Z, Y, J, H and Ks filters, during 2009 October 16 to November 2. (3 data files).

The Combating Obesity in Māori and Pasifika Adolescent School-Children Study: COMPASS Methodology and Study Protocol

PubMed Central

Stoner, Lee; Shultz, Sarah P.; Lambrick, Danielle M.; Krebs, Jeremy; Weatherall, Mark; Palmer, Barry R.; Lane, Andrew M.; Kira, Geoff; Witter, Trevor; Williams, Michelle A.

2013-01-01

Background: Lifestyle modifications including, physical activity can reduce obesity-related morbidity and subsequent cardiovascular disease in youth. This study will investigate the efficacy of a culturally-sensitive, non-contact, boxing-orientated training program on obesity and related cardio-metabolic conditions in Māori and Pasifika adolescents. Details of the methodological aspects of recruitment, inclusion criteria, randomization, cultural sensitivity, intervention program, assessments, process evaluation, and statistical analyses are described. Methods: This study will be a community based, New Zealand, randomized control trial (RCT). Male and female obese (body mass index >95th percentile) Māori and Pasifika adolescents aged 14-16 years will be recruited and the sample size will be confirmed through a feasibility study. Combating Obesity in Māori and Pasifika Adolescent School-children Study (COMPASS) is a 6-month, theory-based program, conducted 3-times/week in a culturally appropriate setting. Each session includes 40 min boxing-orientated training and 30 min resistance training. Assessments will be made at baseline, 3-months, 6-months, 12-months, and 24-months. Main outcomes include abdominal obesity, endothelial function, and insulin resistance. Other outcomes include arterial stiffness, lipid profile, inflammatory biomarkers, well-being, and aerobic fitness. Control measures include physical activity, sleep behavior, and dietary intake. Results: As a protocol paper there are no specific results to present, our purpose is to share our RCT design with the scientific community. Conclusions: COMPASS will be used to provide direction for exercise prescription policy in at-risk Māori and Pasifika adolescents. PMID:23930168

Māori oral histories and the impact of tsunamis in Aotearoa-New Zealand

NASA Astrophysics Data System (ADS)

King, Darren N.; Shaw, Wendy S.; Meihana, Peter N.; Goff, James R.

2018-03-01

Māori oral histories from the northern South Island of Aotearoa-New Zealand provide details of ancestral experience with tsunami(s) on, and surrounding, Rangitoto (D'Urville Island). Applying an inductive-based methodology informed by collaborative storytelling, exchanges with key informants from the Māori kin groups of Ngāti Koata and Ngāti Kuia reveal that a folk tale, published in 1907, could be compared to and combined with active oral histories to provide insights into past catastrophic saltwater inundations. Such histories reference multiple layers of experience and meaning, from memorials to ancestral figures and their accomplishments to claims about place, authority and knowledge. Members of Ngāti Koata and Ngāti Kuia, who permitted us to record some of their histories, share the view that there are multiple benefits to be gained by learning from differences in knowledge, practice and belief. This work adds to scientific as well as Maōri understandings about tsunami hazards (and histories). It also demonstrates that to engage with Māori oral histories (and the people who genealogically link to such stories) requires close attention to a politics of representation, in both past recordings and current ways of retelling, as well as sensitivities to the production of new and plural knowledges. This paper makes these narratives available to a new audience, including those families who no longer have access to them, and recites these in ways that might encourage plural knowledge development and co-existence.

Titration of DnaA protein by oriC DnaA-boxes increases dnaA gene expression in Escherichia coli.

PubMed Central

Hansen, F G; Koefoed, S; Sørensen, L; Atlung, T

1987-01-01

Binding of the DnaA protein to its binding sites, the DnaA-boxes (TTATCCACA), was measured by a simple physiological approach. The presence of extra DnaA-boxes in growing cells leads to a derepression of dnaA gene expression, measured as beta-galactosidase activity of a dnaA-lacZ fusion polypeptide. Different DnaA-boxes caused different degrees of derepression indicating that the DnaA protein requires sequences in addition to the DnaA-box for efficient binding. The DnaA-boxes in oriC might act cooperatively in binding of the DnaA protein. The derepressed levels of DnaA protein obtained in a strain carrying an oriC+-pBR322 chimera were very high and sufficient to activate oriC on the chimeric plasmid, which was maintained at a copy number more than three times that of pBR322. PMID:3034578

Chromospheric activity on the late-type star V1355 Ori using Lijiang 1.8-m and 2.4-m telescopes

NASA Astrophysics Data System (ADS)

Pi, Qing-Feng; Zhang, Li-Yun; Chang, Liang; Han, Xian-Ming; Lu, Hong-Peng; Zhang, Xi-Liang; Wang, Dai-Mei

2016-10-01

We obtained new high-resolution spectra using the Lijiang 1.8-m and 2.4-m telescopes to investigate the chromospheric activities of V1355 Ori as indicated in the behaviors of Ca ii H&K, Hδ, Hγ, Hβ, Na i D1, D2, Hα and Ca ii infrared triplet (IRT) lines. The observed spectra show obvious emissions above the continuum in Ca ii H&K lines, absorptions in the Hδ, Hγ, Hβ and Na i D1, D2 lines, variable behavior (filled-in absorption, partial emission with a core absorption component or emission above the continuum) in the Hα line, and weak self-reversal emissions in the strong filled-in absorptions of the Ca ii IRT lines. We used a spectral subtraction technique to analyze our data. The results show no excess emission in the Hδ and Hγ lines, very weak excess emissions in the Na i D1, D2 lines, excess emission in the Hβ line, clear excess emission in the Hα line, and excess emissions in the Ca ii IRT lines. The value of the ratio of EW8542/EW8498 is in the range 0.9 to 1.7, which implies that chromospheric activity might have been caused by plage events. The value of the ratio E Hα/E Hβ is above 3, indicating that the Balmer lines would arise from prominence-like material. We also found time variations in light curves associated with equivalent widths of chromospheric activity lines in the Na i D1, D2, Ca ii IRT and Hα lines in particular. These phenomena can be explained by plage events, which are consistent with the behavior of chromospheric activity indicators.

VizieR Online Data Catalog: Parenago Catalog of Stars in Orion Nebula (Parenago 1954)

NASA Astrophysics Data System (ADS)

Parenago, P. P.

1997-10-01

The present catalogue is a machine-readable version of the catalogue of stars in the area of the Orion nebula, published by P.P. Parenago (1954). The sky area between 5h 24m and 5h 36m in right ascension (1900.0) and between -4 and -7 degrees in declination (1900.0), containing the Orion nebula, has been investigated in that work. Ten of variable stars in original Parenago (1954) catalogue had CSV numbers (Kukarkin et al., 1951) but since that time all of them were confirmed as variables and included in GCVS (Kholopov et al., 1985a&b, 1987). We superseded CSV-numbers by GCVS-names in the machine-readable version for the following stars: ------------------------------------------------ Number in CSV-number GCVS-name the catalogue ------------------------------------------------ 1605 606 V372 ORI 1613 607 V373 ORI 1635 608 V374 ORI 1713 609 V375 ORI 1748 610 V387 ORI 1762 100569 V376 ORI 1974 617 V377 ORI 2183 625 V388 ORI 2393 630 V380 ORI 2478 634 V381 ORI ------------------------------------------------ (1 data file).

Addition of Kinesio Taping of the orbicularis oris muscles to speech therapy rapidly improves drooling in children with neurological disorders.

PubMed

Mikami, Denise Lica Yoshimura; Furia, Cristina Lemos Barbosa; Welker, Alexis Fonseca

2017-09-21

To evaluate the effects of Kinesio Taping (KT) of the orbicularis oris muscles as an adjunct to standard therapy for drooling. Fifteen children with neurological disorders and drooling received speech therapy and twice-weekly KT of the orbicularis muscles over a 30-day period. Drooling was assessed by six parameters: impact on the life of the child and caregiver; severity of drooling; frequency of drooling; drooling volume (estimated by number of bibs used); salivary leak; and interlabial gap. Seven markers of oral motor skills were also assessed. KT of the orbicularis oris region reduced the interlabial gap. All oral motor skills and almost all markers of drooling improved after 15 days of treatment. In this sample of children with neurological disorders, adding KT of the orbicularis oris muscles to speech therapy caused rapid improvement in oral motor skills and drooling.

Māori patients' experiences and perspectives of chronic kidney disease: a New Zealand qualitative interview study.

PubMed

Walker, Rachael C; Walker, Shayne; Morton, Rachael L; Tong, Allison; Howard, Kirsten; Palmer, Suetonia C

2017-01-19

To explore and describe Māori (the indigenous people of New Zealand) patients' experiences and perspectives of chronic kidney disease (CKD), as these are largely unknown for indigenous groups with CKD. Face-to-face, semistructured interviews with purposive sampling and thematic analysis. 3 dialysis centres in New Zealand (NZ), all of which offered all forms of dialysis modalities. 13 Māori patients with CKD and who were either nearing the need for dialysis or had started dialysis within the previous 12 months. The Māori concepts of whakamā (disempowerment and embarrassment) and whakamana (sense of self-esteem and self-determination) provided an overarching framework for interpreting the themes identified: disempowered by delayed CKD diagnosis (resentment of late diagnosis; missed opportunities for preventive care; regret and self-blame); confronting the stigma of kidney disease (multigenerational trepidation; shame and embarrassment; fear and denial); developing and sustaining relationships to support treatment decision-making (importance of family/whānau; valuing peer support; building clinician-patient trust); and maintaining cultural identity (spiritual connection to land; and upholding inner strength/mana). Māori patients with CKD experienced marginalisation within the NZ healthcare system due to delayed diagnosis, a focus on individuals rather than family, multigenerational fear of dialysis, and an awareness that clinicians are not aware of cultural considerations and values during decision-making. Prompt diagnosis to facilitate self-management and foster trust between patients and clinicians, involvement of family and peers in dialysis care, and acknowledging patient values could strengthen patient engagement and align decision-making with patient priorities. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Relating Radiative Fluxes on Arctic Sea Ice Area Using Arctic Observation and Reanalysis Integrated System (ArORIS)

NASA Astrophysics Data System (ADS)

Sledd, A.; L'Ecuyer, T. S.

2017-12-01

With Arctic sea ice declining rapidly and Arctic temperatures rising faster than the rest of the globe, a better understanding of the Arctic climate, and ice cover-radiation feedbacks in particular, is needed. Here we present the Arctic Observation and Reanalysis Integrated System (ArORIS), a dataset of integrated products to facilitate studying the Arctic using satellite, reanalysis, and in-situ datasets. The data include cloud properties, radiative fluxes, aerosols, meteorology, precipitation, and surface properties, to name just a few. Each dataset has uniform grid-spacing, time-averaging and naming conventions for ease of use between products. One intended use of ArORIS is to assess Arctic radiation and moisture budgets. Following that goal, we use observations from ArORIS - CERES-EBAF radiative fluxes and NSIDC sea ice fraction and area to quantify relationships between the Arctic energy balance and surface properties. We find a discernable difference between energy budgets for years with high and low September sea ice areas. Surface fluxes are especially responsive to the September sea ice minimum in months both leading up to September and the months following. In particular, longwave fluxes at the surface show increased sensitivity in the months preceding September. Using a single-layer model of solar radiation we also investigate the individual responses of surface and planetary albedos to changes in sea ice area. By partitioning the planetary albedo into surface and atmospheric contributions, we find that the atmospheric contribution to planetary albedo is less sensitive to changes in sea ice area than the surface contribution. Further comparisons between observations and reanalyses can be made using the available datasets in ArORIS.

Assessment of cross-sectional thickness and activity of masseter, anterior temporalis and orbicularis oris muscles in oral submucous fibrosis patients and healthy controls: an ultrasonography and electromyography study

PubMed Central

Bhowate, R R; Sharda, N

2014-01-01

Objectives: Oral submucous fibrosis (OSMF) is an insidious chronic disease that is associated with significant functional morbidity and an increased risk for malignancy. It initially affects the lamina propria of the oral mucosa, and, as the disease progresses, it involves the submucosa and deeper tissue, including muscles of the oral cavity, resulting in loss of fibroelasticity. OSMF is a pre-malignant condition mainly caused by areca nut chewing. The aim of this study was to find out the involvement of muscles of mastication and facial expression in patients with OSMF by assessing the cross-sectional thickness and activity of the masseter, anterior temporalis and orbicularis oris muscles by ultrasonography and electromyography and comparing with healthy controls and also to find out any correlation between the ultrasonographic cross-sectional thicknesses of the masseter, anterior temporalis and orbicularis oris muscles with electromyographic activity. Methods: 40 patients with OSMF were included in the study group, and the patients were divided into four groups on the basis of interincisal mouth opening, i.e. Group I (mouth opening >35 mm), Group II (mouth opening between 30 and 35 mm), Group III (mouth opening between 20 and 30 mm) and Group IV (mouth opening <20 mm). Ultrasonographic cross-sectional thickness and electromyographic activity (amplitude and duration) of the masseter, anterior temporalis and orbicualris oris muscles were recorded in patients with OSMF and 20 controls. Intergroup comparison of ultrasonographic cross-sectional thickness and activity (amplitude and duration) was done, and Pearson's correlation coefficient was applied to find out any relation between ultrasonographic and electromyographic findings. Results: Thickness and activity of the masseter muscle was significantly reduced in Group IV (mouth opening <20 mm) when compared with the control group. The anterior temporalis and orbicularis oris muscles remained unaffected. A

The Architecture of the GW Ori Young Triple-star System and Its Disk: Dynamical Masses, Mutual Inclinations, and Recurrent Eclipses

NASA Astrophysics Data System (ADS)

Czekala, Ian; Andrews, Sean M.; Torres, Guillermo; Rodriguez, Joseph E.; Jensen, Eric L. N.; Stassun, Keivan G.; Latham, David W.; Wilner, David J.; Gully-Santiago, Michael A.; Grankin, Konstantin N.; Lund, Michael B.; Kuhn, Rudolf B.; Stevens, Daniel J.; Siverd, Robert J.; James, David; Gaudi, B. Scott; Shappee, Benjamin J.; Holoien, Thomas W.-S.

2017-12-01

We present spatially and spectrally resolved Atacama Large Millimeter/submillimeter Array (ALMA) observations of gas and dust orbiting the pre-main-sequence hierarchical triple-star system GW Ori. A forward modeling of the 13CO and C18O J = 2–1 transitions permits a measurement of the total stellar mass in this system, 5.29+/- 0.09 {M}ȯ , and the circumtriple disk inclination, 137\\buildrel{\\circ}\\over{.} 6+/- 2\\buildrel{\\circ}\\over{.} 0. Optical spectra spanning a 35 yr period were used to derive new radial velocities and, coupled with a spectroscopic disentangling technique, revealed that the A and B components of GW Ori form a double-lined spectroscopic binary with a period of 241.50 ± 0.05 days; a tertiary companion orbits that inner pair with a period of 4218 ± 50 days. Combining the results from the ALMA data and the optical spectra with three epochs of astrometry in the literature, we constrain the individual stellar masses in the system ({M}{{A}}≈ 2.7 {M}ȯ , {M}{{B}}≈ 1.7 {M}ȯ , {M}{{C}}≈ 0.9 {M}ȯ ) and find strong evidence that at least one of the stellar orbital planes (and likely both) is misaligned with the disk plane by as much as 45°. A V-band light curve spanning 30 yr reveals several new ∼30-day eclipse events 0.1–0.7 mag in depth and a 0.2 mag sinusoidal oscillation that is clearly phased with the AB–C orbital period. Taken together, these features suggest that the A–B pair may be partially obscured by material in the inner disk as the pair approaches apoastron in the hierarchical orbit. Lastly, we conclude that stellar evolutionary models are consistent with our measurements of the masses and basic photospheric properties if the GW Ori system is ∼1 Myr old.

Dramatic Evolution of the Disk-shaped Secondary in the Orion Trapezium Star θ1 Ori B1 (BM Ori): MOST Satellite Observations

NASA Astrophysics Data System (ADS)

Windemuth, Diana; Herbst, William; Tingle, Evan; Fuechsl, Rachel; Kilgard, Roy; Pinette, Melanie; Templeton, Matthew; Henden, Arne

2013-05-01

The eclipsing binary θ1 Orionis B1, variable star designation BM Ori, is the faintest of the four well-known Trapezium stars at the heart of the Orion Nebula. The primary is a B3 star (~6 M ⊙) but the nature of the secondary (~2 M ⊙) has long been mysterious, since the duration and shape of primary eclipse are inappropriate for any sort of ordinary star. Here we report nearly continuous photometric observations obtained with the MOST satellite over ~4 cycles of the 6.47 d binary period. The light curve is of unprecedented quality, revealing a deep, symmetric primary eclipse as well as a clear reflection effect and secondary eclipse. In addition, there are other small disturbances, some of which repeat at the same phase over the four cycles monitored. The shape of the primary light curve has clearly evolved significantly over the past 40 years. While its overall duration and depth have remained roughly constant, the slopes of the descent and ascent phases are significantly shallower now than in the past and its distinctive flat-bottomed "pseudo-totality" is much less obvious or even absent in the most recent data. We further demonstrate that the primary eclipse was detected at X-ray wavelengths during the Chandra Orion Ultradeep Project (COUP) study. The light curve continues to be well modeled by a self-luminous and reflective disk-shaped object seen nearly edge-on orbiting the B3 primary. The dramatic change in shape over four decades is modeled as an opacity variation in a tenuous outer envelope or disk of the secondary object. We presume that the secondary is an extremely young protostar at an earlier evolutionary phase than can be commonly observed elsewhere in the Galaxy and that the opacity variations observed are related to its digestion of some accreted matter over the last 50-100 years. Indeed, this object deserves continued observational and theoretical attention as the youngest known eclipsing binary system.

Localized DNA melting and structural pertubations in the origin of replication, oriC, of Escherichia coli in vitro and in vivo.

PubMed Central

Gille, H; Messer, W

1991-01-01

The leftmost region of the Escherichia coli origin of DNA replication (oriC) contains three tandemly repeated AT-rich 13mers which have been shown to become single-stranded during the early stages of initiation in vitro. Melting is induced by the ATP form of DnaA, the initiator protein of DNA replication. KMnO4 was used to probe for single-stranded regions and altered DNA conformation during the initiation of DNA replication at oriC in vitro and in vivo. Unpairing in the AT-rich 13mer region is thermodynamically stable even in the absence of DnaA protein, but only when divalent cations are omitted from the reaction. In the presence of Mg2+, oriC melting is strictly DnaA dependent. The sensitive region is distinct from that detected in the absence of DnaA as it is located further to the left within the minimal origin. In addition, the DNA is severely distorted between the three 13mers and the IHF binding site in oriC. A change of conformation can also be observed during the initiation of DNA replication in vivo. This is the first in vivo evidence for a structural change at the 13mers during initiation complex formation. Images PMID:2026151

Electromyographic fatigue of orbicular oris muscles during exercises in mouth and nasal breathing children.

PubMed

Busanello-Stella, Angela Ruviaro; Blanco-Dutra, Ana Paula; Corrêa, Eliane Castilhos Rodrigues; Silva, Ana Maria Toniolo da

2015-01-01

To investigate the process of fatigue in orbicularis oris muscles by analyzing the median frequency of electromyographic signal and the referred fatigue time, according to the breathing mode and the facial pattern. The participants were 70 children, aged 6 to 12 years, who matched the established criteria. To be classified as 36 nasal-breathing and 34 mouth-breathing children, they underwent speech-language, otorhinolaryngologic, and cephalometric evaluation. For the electromyographic assessment, the children had to sustain lip dumbbells weighing 40, 60, and 100 g and a lip exerciser, until the feeling of fatigue. Median frequency was analyzed in 5, 10, 15, and 20 seconds of activity. The referred time of the feeling of fatigue was also recorded. Data were analyzed through the analysis of variance--repeated measures (post hoc Tukey's test), Kruskal-Wallis test, and Mann-Whitney U-test. A significant decrease in the median frequency from 5 seconds of activity was observed, independently from the comparison between the groups. On comparison, the muscles did not show significant decrease. The reported time for the feeling of fatigue was shorter for mouth-breathing individuals. This feeling occurred after the significant decrease in the median frequency. There were signals that indicated myoelectric fatigue for the orbicularis oris muscles, in both groups analyzed, from the first 5 seconds of activity. Myoelectric fatigue in the orbicularis oris muscles preceded the reported feeling of fatigue in all groups. The account for fatigue time was influenced by only the breathing pattern, occurring more precociously in mouth-breathing children.

Contour Curvature As an Invariant Code for Objects in Visual Area V4

PubMed Central

Pasupathy, Anitha

2016-01-01

Size-invariant object recognition—the ability to recognize objects across transformations of scale—is a fundamental feature of biological and artificial vision. To investigate its basis in the primate cerebral cortex, we measured single neuron responses to stimuli of varying size in visual area V4, a cornerstone of the object-processing pathway, in rhesus monkeys (Macaca mulatta). Leveraging two competing models for how neuronal selectivity for the bounding contours of objects may depend on stimulus size, we show that most V4 neurons (∼70%) encode objects in a size-invariant manner, consistent with selectivity for a size-independent parameter of boundary form: for these neurons, “normalized” curvature, rather than “absolute” curvature, provided a better account of responses. Our results demonstrate the suitability of contour curvature as a basis for size-invariant object representation in the visual cortex, and posit V4 as a foundation for behaviorally relevant object codes. SIGNIFICANCE STATEMENT Size-invariant object recognition is a bedrock for many perceptual and cognitive functions. Despite growing neurophysiological evidence for invariant object representations in the primate cortex, we still lack a basic understanding of the encoding rules that govern them. Classic work in the field of visual shape theory has long postulated that a representation of objects based on information about their bounding contours is well suited to mediate such an invariant code. In this study, we provide the first empirical support for this hypothesis, and its instantiation in single neurons of visual area V4. PMID:27194333

Development of oriC-Based Plasmids for Mesoplasma florum.

PubMed

Matteau, Dominick; Pepin, Marie-Eve; Baby, Vincent; Gauthier, Samuel; Arango Giraldo, Mélissa; Knight, Thomas F; Rodrigue, Sébastien

2017-04-01

The near-minimal bacterium Mesoplasma florum constitutes an attractive model for systems biology and for the development of a simplified cell chassis in synthetic biology. However, the lack of genetic engineering tools for this microorganism has limited our capacity to understand its basic biology and modify its genome. To address this issue, we have evaluated the susceptibility of M. florum to common antibiotics and developed the first generation of artificial plasmids able to replicate in this bacterium. Selected regions of the predicted M. florum chromosomal origin of replication ( oriC ) were used to create different plasmid versions that were tested for their transformation frequency and stability. Using polyethylene glycol-mediated transformation, we observed that plasmids harboring both rpmH-dnaA and dnaA-dnaN intergenic regions, interspaced or not with a copy of the dnaA gene, resulted in a frequency of ∼4.1 × 10 -6 transformants per viable cell and were stably maintained throughout multiple generations. In contrast, plasmids containing only one M. florum oriC intergenic region or the heterologous oriC region of Mycoplasma capricolum , Mycoplasma mycoides , or Spiroplasma citri failed to produce any detectable transformants. We also developed alternative transformation procedures based on electroporation and conjugation from Escherichia coli , reaching frequencies up to 7.87 × 10 -6 and 8.44 × 10 -7 transformants per viable cell, respectively. Finally, we demonstrated the functionality of antibiotic resistance genes active against tetracycline, puromycin, and spectinomycin/streptomycin in M. florum Taken together, these valuable genetic tools will facilitate efforts toward building an M. florum -based near-minimal cellular chassis for synthetic biology. IMPORTANCE Mesoplasma florum constitutes an attractive model for systems biology and for the development of a simplified cell chassis in synthetic biology. M. florum is closely related to the mycoides

How Indigenous values shaped a successful multi-year Soil Health program in Aotearoa-New Zealand (presented from both indigenous Māori and western science perspectives)

NASA Astrophysics Data System (ADS)

Stevenson, B.; Harmsworth, G.; Kalaugher, E.

2017-12-01

New Zealand is a multicultural society, founded on the Treaty of Waitangi which when enshrined into various legislation and national policy, provides incentive to incorporate indigenous Māori world views into nationally funded science and research programmes. Here we discuss how the integration of indigenous world views and western science were combined in a research proposal that resulted in successful funding for a 5 year collaborative science programme. The programme strives to develop an expanded national soil health framework for New Zealand that will be used by policy makers, local government, indigenous Māori, industry, and primary sector groups to maintain the natural capital and productivity of soils within environmental constraints. Soil health is fundamental to economic, social, and human wellbeing, and provides a myriad of ecosystem and environmental services, such as those sustaining food and fibre production. Typically soil health is defined by "dynamic" soil characteristics that are susceptible to changes in land use or land management over relatively short time frames (years to decades). Soil resilience, however, is a much longer-term concept that is not well captured in current soil health thinking. The Māori world view encapsulates such long term thinking through interconnected Māori values and inter-generational concepts (e.g., whakapapa, rangatiratanga, manawhenua, kaitiakitanga, mauri) that provide the basis for indigenous resource management in Aotearoa-New Zealand. These values and recognition of the Treaty of Waitangi provide authority and rights to manage resources according to tikanga (customs, principles). Māori environmental concepts and knowledge combined with science concepts for understanding soil health and resilience, served as a powerful central theme for the design and implementation of this science program. Māori involvement and capability development are integral to this research effort and we believe the synthesis of Māori

Delta Ori Phase-Dependent Variability from Chandra and MOST Campaign

NASA Astrophysics Data System (ADS)

Nichols, Joy; Naze, Yael; Moffatt, Anthony F. J.; Corcoran, Michael; Richardson, Noel; Williams, S.; Pollock, A. M. T.; Ignace, Richard; Hole, T.; Waldron, W.; Evans, Nancy Remage; MOST Collaboration

2013-06-01

We report preliminary results from variability analysis of delta Ori in Chandra high-resolution X-ray spectroscopy and concurrent MOST high-precision optical photometry. With nearly complete phase coverage of the 5-day eclipsing binary orbit, it is possible to measure directly radial velocity and flux variations as a function of phase, leading to a mapping of the stellar wind distribution for the massive primary star. The phase dependence of the X-ray overall intensity and the comparative behavior of the emission lines are also presented.

Interkingdom cooperation between Candida albicans, Streptococcus oralis and Actinomyces oris modulates early biofilm development on denture material.

PubMed

Cavalcanti, Indira M G; Nobbs, Angela H; Ricomini-Filho, Antônio Pedro; Jenkinson, Howard F; Del Bel Cury, Altair A

2016-04-01

Candida-associated stomatitis affects up to 60% of denture wearers, and Candida albicans remains the most commonly isolated fungal species. The oral bacteria Actinomyces oris and Streptococcus oralis are abundant in early dental plaque. The aims of this study were to determine the effects of S. oralis and A. oris on the development of C. albicans biofilms on denture material. Resin discs were coated with saliva and at early (1.5 h) or later (24 h) stages of biofilm development, cell numbers of each species were determined. Spatial distribution of microorganisms was visualized by confocal scanning laser microscopy of biofilms labelled by differential fluorescence or by fluorescence in situ hybridization. Interkingdom interactions underpinning biofilm development were also evaluated planktonically utilizing fluorescence microscopy. Synergistic interactions between all three species occurred within biofilms and planktonically. Bacterial cells coaggregated with each other and adhered singly or in coaggregates to C. albicans hyphal filaments. Streptococcus oralis appeared to enhance hyphal filament production and C. albicans biovolume was increased 2-fold. Concomitantly, cell numbers of S. oralis and A. oris were enhanced by C. albicans. Thus, cooperative physical and metabolic processes occurring between these three microbial species intensify pathogenic plaque communities on denture surfaces. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

In vivo dynamics of EBNA1-oriP interaction during latent and lytic replication of Epstein-Barr virus.

PubMed

Daikoku, Tohru; Kudoh, Ayumi; Fujita, Masatoshi; Sugaya, Yutaka; Isomura, Hiroki; Tsurumi, Tatsuya

2004-12-24

The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is required for maintenance of the viral genome DNA during the latent phase of EBV replication but continues to be synthesized after the induction of viral productive replication. An EBV genome-wide chromatin immunoprecipitation assay revealed that EBNA1 constantly binds to oriP of the EBV genome during not only latent but also lytic infection. Although the total levels of EBNA1 proved constant throughout the latter, the levels of the oriP-bound form were increased as lytic infection proceeded. EBV productive DNA replication occurs at discrete sites in nuclei, called replication compartments, where viral replication proteins are clustered. Confocal laser microscopic analyses revealed that whereas EBNA1 was distributed broadly in nuclei as fine punctate dots during the latent phase of infection, the protein became redistributed to the viral replication compartments and localized as distinct spots within and/or nearby the compartments after the induction of lytic replication. Taking these findings into consideration, oriP regions of the EBV genome might be organized by EBNA1 into replication domains that may set up scaffolding for lytic replication and transcription.

How efficient are New Zealand's District Health Boards at producing life expectancy gains for Māori and Europeans?

PubMed

Sandiford, Peter; Consuelo, David Juan José Vivas; Rouse, Paul

2017-04-01

Use data envelopment analysis (DEA) to measure the efficiency of New Zealand's District Health Boards (DHBs) at achieving gains in Māori and European life expectancy (LE). Using life tables for 2006 and 2013, a two-output DEA model established the production possibility frontier for Māori and European LE gain. Confidence limits were generated from a 10,000 replicate Monte Carlo simulation. Results support the use of LE change as an indicator of DHB efficiency. DHB mean income and education were related to initial LE but not to its rate of change. LE gains were unrelated to either the initial level of life expectancy or to the proportion of Māori in the population. DHB efficiency ranged from 79% to 100%. Efficiency was significantly correlated with DHB financial performance. Changes in LE did not depend on the social characteristics of the DHB. The statistically significant association between efficiency and financial performance supports its use as an indicator of managerial effectiveness. Implications for public health: Efficient health systems achieve better population health outcomes. DEA can be used to measure the relative efficiency of sub-national health authorities at achieving health gain and equity outcomes. © 2016 The Authors.

Face-to-face versus telephone delivery of the Green Prescription for Māori and New Zealand Europeans with type-2 diabetes mellitus: influence on participation and health outcomes.

PubMed

Williams, Margaret; Cairns, Simeon; Simmons, David; Rush, Elaine

2017-11-10

In Aotearoa/New Zealand, the proportion of Māori who participate in the national Green Prescription lifestyle programme is lower than for New Zealand Europeans. We compared the uptake and effectiveness of two modes of Green Prescription delivery: face-to-face and telephone among both Māori and New Zealand Europeans. Sixty-eight Māori and 70 New Zealand Europeans with type-2 diabetes participated in this six-month randomised trial of the two modes of delivery. Recruitment integrated an explicitly Māori culturally sensitive approach. All participants received lifestyle intervention. Anthropometry, blood lipids and glycated haemoglobin were measured before and after the intervention. The face-to-face approach (first meeting) yielded 100% uptake into the programme among both Māori and New Zealand Europeans. At six months there were overall reductions in weight (1.8; [95 CI%, 0.6, 2.9kg]), waist circumference (3.7 [2.6, 4.8cm]), and total cholesterol (0.6 [0.3, 0.9mmol/l]) and glycated haemoglobin (3.1 [-0.2, 6.7mmol/mol]). There were no significant differences by mode of delivery, ethnicity or gender. The Green Prescription programme resulted in small but clinically favourable improvements in health outcomes for type-2 diabetes patients, regardless of the mode of delivery for both Māori and New Zealand Europeans.

Dietary intakes of European, Māori, Pacific and Asian adults living in Auckland: the Diabetes, Heart and Health Study.

PubMed

Metcalf, Patricia A; Scragg, Robert R K; Schaaf, David; Dyall, Lorna; Black, Peter N; Jackson, Rod

2008-10-01

To compare dietary intakes of European, Māori, Pacific, and Asian men and women living in Auckland. Daily nutrient intakes were calculated from a self-administered food frequency questionnaire from participants in a cross-sectional health screening study carried out between 2002 and 2003. Participants were 4,007 Māori, Pacific, Asian and European people (1,915 men, 2,092 women) aged 35 to 74 years. Compared with Europeans, Māori and Pacific men had higher total energy intakes per day, while Asians had lower intakes. A similar pattern was observed for carbohydrate and fat consumption. While protein and cholesterol consumption tended to be lower in Europeans than the other three ethnic groups, alcohol consumption and calcium intakes were highest among Europeans. Many of the differences between ethnic groups were attenuated when nutrient consumption was expressed as their percentage contribution to total energy intake suggesting that total food consumption was the major determinant of ethnic differences in nutrient intakes. There were substantial differences in dietary habits, food selections and cooking practices between European, Māori, Pacific and Asian participants. However, the observed differences were in the area of serving sizes and frequency of consumption of certain foods than to major differences in the range of foods and nutrients consumed or the percentage contribution of carbohydrate, fat or protein to total energy intake. The development of strategies to reduce serving sizes and the frequency of consumption of certain foods will be required to help address the major nutrition-related health problems in New Zealand.

Interactions between Streptococcus oralis, Actinomyces oris, and Candida albicans in the development of multispecies oral microbial biofilms on salivary pellicle.

PubMed

Cavalcanti, I M G; Del Bel Cury, A A; Jenkinson, H F; Nobbs, A H

2017-02-01

The fungus Candida albicans is carried orally and causes a range of superficial infections that may become systemic. Oral bacteria Actinomyces oris and Streptococcus oralis are abundant in early dental plaque and on oral mucosa. The aims of this study were to determine the mechanisms by which S. oralis and A. oris interact with each other and with C. albicans in biofilm development. Spatial distribution of microorganisms was visualized by confocal laser scanning microscopy of biofilms labeled by differential fluorescence or by fluorescence in situ hybridization (FISH). Actinomyces oris and S. oralis formed robust dual-species biofilms, or three-species biofilms with C. albicans. The bacterial components tended to dominate the lower levels of the biofilms while C. albicans occupied the upper levels. Non-fimbriated A. oris was compromised in biofilm formation in the absence or presence of streptococci, but was incorporated into upper biofilm layers through binding to C. albicans. Biofilm growth and hyphal filament production by C. albicans was enhanced by S. oralis. It is suggested that the interkingdom biofilms are metabolically coordinated to house all three components, and this study demonstrates that adhesive interactions between them determine spatial distribution and biofilm architecture. The physical and chemical communication processes occurring in these communities potentially augment C. albicans persistence at multiple oral cavity sites. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Retrofitting BACs with G418 resistance, luciferase, and oriP and EBNA-1 – new vectors for in vitro and in vivo delivery

PubMed Central

Magin-Lachmann, Christine; Kotzamanis, George; D'Aiuto, Leonardo; Wagner, Ernst; Huxley, Clare

2003-01-01

Background Bacterial artificial chromosomes (BACs) have been used extensively for sequencing the human and mouse genomes and are thus readily available for most genes. The large size of BACs means that they can generally carry intact genes with all the long range controlling elements that drive full levels of tissue-specific expression. For gene expression studies and gene therapy applications it is useful to be able to retrofit the BACs with selectable genes such as G418 resistance, reporter genes such as luciferase, and oriP/EBNA-1 from Epstein Barr virus which allows long term episomal maintenance in mammalian cells. Results We describe a series of retrofitting plasmids and a protocol for in vivo loxP/Cre recombination. The vector pRetroNeo carries a G418 resistance cassette, pRetroNeoLuc carries G418 resistance and a luciferase expression cassette, pRetroNeoLucOE carries G418 resistance, luciferase and an oriP/EBNA-1 cassette and pRetroNeoOE carries G418 resistance and oriP/EBNA-1. These vectors can be efficiently retrofitted onto BACs without rearrangement of the BAC clone. The luciferase cassette is expressed efficiently from the retrofitting plasmids and from retrofitted BACs after transient transfection of B16F10 cells in tissue culture and after electroporation into muscles of BALB/c mice in vivo. We also show that a BAC carrying GFP, oriP and EBNA-1 can be transfected into B16F10 cells with Lipofectamine 2000 and can be rescued intact after 5 weeks. Conclusion The pRetro vectors allow efficient retrofitting of BACs with G418 resistance, luciferase and/or oriP/EBNA-1 using in vivo expression of Cre. The luciferase reporter gene is expressed after transient transfection of retrofitted BACs into cells in tissue culture and after electroporation into mouse muscle in vivo. OriP/EBNA-1 allows stable maintenance of a 150-kb BAC without rearrangement for at least 5 weeks. PMID:12609052

Effects of mouth rehabilitation with removable complete dentures on stimulus perception and the electromyographic activity of the orbicularis oris muscle.

PubMed

de Caxias, Fernanda P; Dos Santos, Daniela M; Goiato, Marcelo C; Bitencourt, Sandro B; da Silva, Emily V F; Laurindo-Junior, Murilo C B; Turcio, Karina H L

2018-05-01

Many elderly individuals are rehabilitated with removable complete dentures, which require an initial adaptation period for both oral perception and the perioral muscles. Studies assessing the changes in stimulus perception and the electromyographic (EMG) activity of the orbicularis oris muscle shortly after conventional complete denture insertion are lacking. The purpose of this clinical study was to evaluate the effect of mouth rehabilitation with removable complete dentures on stimulus perception and the EMG activity of the orbicularis oris muscle. This study was approved by the Human Research Ethics Committee of the Araçatuba Dental School (São Paulo State University). Fifteen participants who had worn their removable complete dentures for at least 5 years and needed rehabilitation with new prostheses were enrolled in the study. A perception questionnaire was applied, and surface EMG examinations of the orbicularis oris muscle during rest, suction of water with a straw, and pronunciation of the syllables /bah/, /mah/, /pah/, and the word 'Mississippi' were performed before (T0) and 30 (T1) and 100 (T2) days after insertion of the new prostheses. The data were analyzed with the Cochran Q test, McNemar test, 2-way repeated measures ANOVA, and honestly significant difference (HSD) Tukey test (α=.05). Significant improvement was reported in the perception questionnaire in terms of the oral discomfort sensation in the T2 period. EMG activity decreased during rest and suction after insertion of the new prostheses. A statistical difference between the upper and lower fascicles of the orbicularis oris muscle was detected, with a decrease of EMG activity between the T0 and T1 periods on the lower fascicle, except for when pronouncing the /pah/ syllable. Mouth rehabilitation with removable complete dentures decreased oral discomfort and, depending on the oral function, decreased or increased EMG activity of the orbicularis oris muscle. In addition, the lower fascicle

A 1.3 mm SMA survey of 29 variable young stellar objects

NASA Astrophysics Data System (ADS)

Liu, Hauyu Baobab; Dunham, Michael M.; Pascucci, Ilaria; Bourke, Tyler L.; Hirano, Naomi; Longmore, Steven; Andrews, Sean; Carrasco-González, Carlos; Forbrich, Jan; Galván-Madrid, Roberto; Girart, Josep M.; Green, Joel D.; Juárez, Carmen; Kóspál, Ágnes; Manara, Carlo F.; Palau, Aina; Takami, Michihiro; Testi, Leonardo; Vorobyov, Eduard I.

2018-04-01

Context. Young stellar objects (YSOs) may undergo periods of active accretion (outbursts), during which the protostellar accretion rate is temporarily enhanced by a few orders of magnitude. Whether or not these accretion outburst YSOs possess similar dust and gas reservoirs to each other, and whether or not their dust and gas reservoirs are similar as quiescent YSOs, are issues yet to be clarified. Aims: The aim of this work is to characterize the millimeter thermal dust emission properties of a statistically significant sample of long and short duration accretion outburst YSOs (i.e., FUors and EXors) and the spectroscopically identified candidates of accretion outbursting YSOs (i.e., FUor-like objects). Methods: We have carried out extensive Submillimeter Array (SMA) observations mostly at 225 GHz (1.33 mm) and 272 GHz (1.10 mm), from 2008 to 2017. We covered accretion outburst YSOs located at <1 kpc distances from the solar system. Results: We analyze all the existing SMA data of such objects, both published and unpublished, in a coherent way to present a millimeter interferometric database of 29 objects. We obtained 21 detections at >3σ significance. Detected sources except for the two cases of V883 Ori and NGC 2071 MM3 were observed with 1″ angular resolution. Overall our observed targets show a systematically higher millimeter luminosity distribution than those of the M* > 0.3 M⊙ Class II YSOs in the nearby (≲400 pc) low-mass star-forming molecular clouds (e.g., Taurus, Lupus, Upp Scorpio, and Chameleon I). In addition, at 1 mm our observed confirmed binaries or triple-system sources are systematically fainter than the rest of the sources even though their 1 mm fluxes are broadly distributed. We may have detected 30-60% millimeter flux variability from V2494 Cyg and V2495 Cyg, from the observations separated by approximately one year.

DRAMATIC EVOLUTION OF THE DISK-SHAPED SECONDARY IN THE ORION TRAPEZIUM STAR {theta}{sup 1} Ori B{sub 1} (BM Ori): MOST SATELLITE OBSERVATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Windemuth, Diana; Herbst, William; Tingle, Evan

2013-05-01

The eclipsing binary {theta}{sup 1} Orionis B{sub 1}, variable star designation BM Ori, is the faintest of the four well-known Trapezium stars at the heart of the Orion Nebula. The primary is a B3 star ({approx}6 M{sub Sun }) but the nature of the secondary ({approx}2 M{sub Sun }) has long been mysterious, since the duration and shape of primary eclipse are inappropriate for any sort of ordinary star. Here we report nearly continuous photometric observations obtained with the MOST satellite over {approx}4 cycles of the 6.47 d binary period. The light curve is of unprecedented quality, revealing a deep,more » symmetric primary eclipse as well as a clear reflection effect and secondary eclipse. In addition, there are other small disturbances, some of which repeat at the same phase over the four cycles monitored. The shape of the primary light curve has clearly evolved significantly over the past 40 years. While its overall duration and depth have remained roughly constant, the slopes of the descent and ascent phases are significantly shallower now than in the past and its distinctive flat-bottomed ''pseudo-totality'' is much less obvious or even absent in the most recent data. We further demonstrate that the primary eclipse was detected at X-ray wavelengths during the Chandra Orion Ultradeep Project (COUP) study. The light curve continues to be well modeled by a self-luminous and reflective disk-shaped object seen nearly edge-on orbiting the B3 primary. The dramatic change in shape over four decades is modeled as an opacity variation in a tenuous outer envelope or disk of the secondary object. We presume that the secondary is an extremely young protostar at an earlier evolutionary phase than can be commonly observed elsewhere in the Galaxy and that the opacity variations observed are related to its digestion of some accreted matter over the last 50-100 years. Indeed, this object deserves continued observational and theoretical attention as the youngest known

Dietary protein intake may reduce hospitalisation due to infection in Māori of advanced age: LiLACS NZ.

PubMed

Wham, Carol; Baggett, Fiona; Teh, Ruth; Moyes, Simon; Kēpa, Mere; Connolly, Martin; Jatrana, Santosh; Kerse, Ngaire

2015-08-01

To investigate factors related to hospital admission for infection, specifically examining nutrient intakes of Māori in advanced age (80+ years). Face-to-face interviews with 200 Māori (85 men) to obtain demographic, social and health information. Diagnoses were validated against medical records. Detailed nutritional assessment using the 24-hour multiple-pass recall method was collected on two separate days. FOODfiles was used to analyse nutrient intake. National Health Index (NHI) numbers were matched to hospitalisations over a two-year period (12 months prior and 12 months following dietary assessment). Selected International Classification of Disease (ICD) codes were used to identify admissions related to infection. A total of 18% of participants were hospitalised due to infection, most commonly lower respiratory tract infection. Controlling for age, gender, NZ deprivation index, diabetes, CVD and chronic lung disease, a lower energy-adjusted protein intake was independently associated with hospitalisation due to infection: OR (95%CI) 1.14 (1.00-1.29), p=0.046. Protein intake may have a protective effect on the nutrition-related morbidity of older Māori. Improving dietary protein intake is a simple strategy for dietary modification aiming to decrease the risk of infections that lead to hospitalisation and other morbidities. © 2015 Public Health Association of Australia.

Narratives and traits in personality development among New Zealand Māori, Chinese, and European adolescents.

PubMed

Reese, Elaine; Chen, Yan; McAnally, Helena M; Myftari, Ella; Neha, Tia; Wang, Qi; Jack, Fiona

2014-07-01

Narrative and trait levels of personality were assessed in a sample of 268 adolescents from age 12 to 21 from New Zealand Māori, Chinese, and European cultures. Adolescents narrated three critical events and completed a Big Five personality inventory. Each narrative was coded for causal and thematic coherence. NZ Chinese adolescents reported lower levels of extraversion, agreeableness, conscientiousness, and openness, and higher levels of neuroticism, than NZ Māori or European adolescents. Cultural differences were also evident in narrative coherence. Adolescents in all three groups demonstrated age-related increases in thematic coherence, but only NZ European adolescents demonstrated the expected age-related increases in causal coherence. Narrative identity and traits were distinct aspects of personality for younger adolescents, but were linked for middle and older adolescents. These findings support the importance of both narrative identity and traits in understanding personality development in adolescents across cultures. Copyright © 2014 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

Human V4 Activity Patterns Predict Behavioral Performance in Imagery of Object Color.

PubMed

Bannert, Michael M; Bartels, Andreas

2018-04-11

Color is special among basic visual features in that it can form a defining part of objects that are engrained in our memory. Whereas most neuroimaging research on human color vision has focused on responses related to external stimulation, the present study investigated how sensory-driven color vision is linked to subjective color perception induced by object imagery. We recorded fMRI activity in male and female volunteers during viewing of abstract color stimuli that were red, green, or yellow in half of the runs. In the other half we asked them to produce mental images of colored, meaningful objects (such as tomato, grapes, banana) corresponding to the same three color categories. Although physically presented color could be decoded from all retinotopically mapped visual areas, only hV4 allowed predicting colors of imagined objects when classifiers were trained on responses to physical colors. Importantly, only neural signal in hV4 was predictive of behavioral performance in the color judgment task on a trial-by-trial basis. The commonality between neural representations of sensory-driven and imagined object color and the behavioral link to neural representations in hV4 identifies area hV4 as a perceptual hub linking externally triggered color vision with color in self-generated object imagery. SIGNIFICANCE STATEMENT Humans experience color not only when visually exploring the outside world, but also in the absence of visual input, for example when remembering, dreaming, and during imagery. It is not known where neural codes for sensory-driven and internally generated hue converge. In the current study we evoked matching subjective color percepts, one driven by physically presented color stimuli, the other by internally generated color imagery. This allowed us to identify area hV4 as the only site where neural codes of corresponding subjective color perception converged regardless of its origin. Color codes in hV4 also predicted behavioral performance in an

Using the Markov chain Monte Carlo method to study the physical properties of GeV-TeV BL Lac objects

NASA Astrophysics Data System (ADS)

Qin, Longhua; Wang, Jiancheng; Yang, Chuyuan; Yuan, Zunli; Mao, Jirong; Kang, Shiju

2018-01-01

We fit the spectral energy distributions (SEDs) of 46 GeV-TeV BL Lac objects in the frame of leptonic one-zone synchrotron self-Compton (SSC) model and investigate the physical properties of these objects. We use the Markov chain Monte Carlo (MCMC) method to obtain the basic parameters, such as magnetic field (B), the break energy of the relativistic electron distribution (γ ^' }b), and the electron energy spectral index. Based on the modeling results, we support the following scenarios for GeV-TeV BL Lac objects. (1) Some sources have large Doppler factors, implying other radiation mechanism should be considered. (2) Compared with flat spectrum quasars (FSRQs), GeV-TeV BL Lac objects have weaker magnetic fields and larger Doppler factors, which cause the ineffective cooling and shift the SEDs to higher bands. Their jet powers are around 4.0 × 1045 erg s-1, compared with radiation power, 5.0 × 1042 erg s-1, indicating that only a small fraction of jet power is transformed into the emission power. (3) For some BL Lacs with large Doppler factors, their jet components could have two substructures, e.g., the fast core and the slow sheath. For most GeV-TeV BL Lacs, Kelvin-Helmholtz instabilities are suppressed by their higher magnetic fields, leading to micro-variability or intro-day variability in the optical bands. (4) Combined with a sample of FSRQs, an anti-correlation between the peak luminosity, Lpk, and the peak frequency, νpk, is obtained, favoring the blazar sequence scenario. In addition, an anti-correlation between the jet power, Pjet, and the break Lorentz factor, γb, also supports the blazar sequence.

Mob/oriT, a mobilizable site-specific recombination system for unmarked genetic manipulation in Bacillus thuringiensis and Bacillus cereus.

PubMed

Wang, Pengxia; Zhu, Yiguang; Zhang, Yuyang; Zhang, Chunyi; Xu, Jianyi; Deng, Yun; Peng, Donghai; Ruan, Lifang; Sun, Ming

2016-06-10

Bacillus thuringiensis and Bacillus cereus are two important species in B. cereus group. The intensive study of these strains at the molecular level and construction of genetically modified bacteria requires the development of efficient genetic tools. To insert genes into or delete genes from bacterial chromosomes, marker-less manipulation methods were employed. We present a novel genetic manipulation method for B. thuringiensis and B. cereus strains that does not leave selection markers. Our approach takes advantage of the relaxase Mob02281 encoded by plasmid pBMB0228 from Bacillus thuringiensis. In addition to its mobilization function, this Mob protein can mediate recombination between oriT sites. The Mob02281 mobilization module was associated with a spectinomycin-resistance gene to form a Mob-Spc cassette, which was flanked by the core 24-bp oriT sequences from pBMB0228. A strain in which the wild-type chromosome was replaced with the modified copy containing the Mob-Spc cassette at the target locus was obtained via homologous recombination. Thus, the spectinomycin-resistance gene can be used to screen for Mob-Spc cassette integration mutants. Recombination between the two oriT sequences mediated by Mob02281, encoded by the Mob-Spc cassette, resulted in the excision of the Mob-Spc cassette, producing the desired chromosomal alteration without introducing unwanted selection markers. We used this system to generate an in-frame deletion of a target gene in B. thuringiensis as well as a gene located in an operon of B. cereus. Moreover, we demonstrated that this system can be used to introduce a single gene or an expression cassette of interest in B. thuringiensis. The Mob/oriT recombination system provides an efficient method for unmarked genetic manipulation and for constructing genetically modified bacteria of B. thuringiensis and B. cereus. Our method extends the available genetic tools for B. thuringiensis and B. cereus strains.

Suppression of initiation defects of chromosome replication in Bacillus subtilis dnaA and oriC-deleted mutants by integration of a plasmid replicon into the chromosomes.

PubMed

Hassan, A K; Moriya, S; Ogura, M; Tanaka, T; Kawamura, F; Ogasawara, N

1997-04-01

We constructed Bacillus subtilis strains in which chromosome replication initiates from the minimal replicon of a plasmid isolated from Bacillus natto, independently of oriC. Integration of the replicon in either orientation at the proA locus (115 degrees on the genetic map) suppressed the temperature-sensitive phenotype caused by a mutation in dnaA, a gene required for initiation of replication from oriC. In addition, in a strain with the plasmid replicon integrated into the chromosome, we were able to delete sequences required for oriC function. These strains were viable but had a slower growth rate than the oriC+ strains. Marker frequency analysis revealed that both pyrD and metD, genes close to proA, showed the highest values among the markers (genes) measured, and those of other markers decreased symmetrically with distance from the site of the integration (proA). These results indicated that the integrated plasmid replicon operated as a new and sole origin of chromosome replication in these strains and that the mode of replication was bidirectional. Interestingly, these mutants produced anucleate cells at a high frequency (about 40% in exponential culture), and the distribution of chromosomes in the cells was irregular. A change in the site and mechanism (from oriC to a plasmid system) of initiation appears to have resulted in a drastic alteration in coordination between chromosome replication and chromosome partition or cell division.

How Many Ultra-Low Delta-v Near Earth Objects Remain Undiscovered? Implications for missions.

NASA Astrophysics Data System (ADS)

Elvis, Martin; Ranjan, Sukrit; Galache, Jose Luis; Murphy, Max

2015-08-01

The past decade has witnessed considerable growth of interest in missions to Near-Earth Objects (NEOs). NEOs are considered prime targets for manned and robotic missions, for both scientific objectives as well as in-situ resource utilization including harvesting of water for propellant and life support and mining of high-value elements for sale on Earth. Appropriate targets are crucial to such missions. Hence, ultra-low delta-v mission targets are strongly favored. Some mission architectures rely on the discovery of more ultra-low delta-v NEOs. In fact the approved and executed NEO missions have all targeted asteroids with ultra-low LEO to asteroid rendezvous delta-v <5.5 km/s.In this paper, we estimate the total NEO population as a function of delta-v, and how many remain to be discovered in various size ranges down to ~100m. We couple the NEOSSat-1 model (Greenstreet et al., 2012) to the NEO size distribution derived from the NEOWISE survey (Mainzer et al., 2011b) to compute an absolute NEO population model. We compare the Minor Planet Center (MPC) catalog of known NEOs to this NEO population model. We compute the delta-v from LEO to asteroid rendezvous orbits using a modified Shoemaker-Helin (S-H) formalism that empirically removes biases found comparing S-H with the results from NHATS. The median delta-v of the known NEOs is 7.3 km/s, the median delta-v predicted by our NEO model is 9.8 km/s, suggesting that undiscovered objects are biased to higher delta-v. The survey of delta-v <10.3 km/s NEOs is essentially complete for objects with diameter D >300 m. However, there are tens of thousands of objects with delta-v <10.3 km/s to be discovered in the D = 50 - 300 m size class (H = 20.4 - 24.3). Our work suggests that there are 100 yet-undiscovered NEOs with delta-v < 5:8 km/s, and 1000 undiscovered NEOs with v < 6.3 km/s. We conclude that, even with complete NEO surveys, the selection of good (i.e. ultra-low delta-v) mission targets is limited given current

A tertiary approach to improving equity in health: quantitative analysis of the Māori and Pacific Admission Scheme (MAPAS) process, 2008-2012.

PubMed

Curtis, Elana; Wikaire, Erena; Jiang, Yannan; McMillan, Louise; Loto, Rob; Airini; Reid, Papaarangi

2015-01-20

Achieving health equity for indigenous and ethnic minority populations requires the development of an ethnically diverse health workforce. This study explores a tertiary admission programme targeting Māori and Pacific applicants to nursing, pharmacy and health sciences (a precursor to medicine) at the University of Auckland (UoA), Aotearoa New Zealand (NZ). Application of cognitive and non-cognitive selection tools, including a Multiple Mini Interview (MMI), are examined. Indigenous Kaupapa Māori methodology guided analysis of the Māori and Pacific Admission Scheme (MAPAS) for the years 2008-2012. Multiple logistic regression models were used to identify the predicted effect of admission variables on the final MAPAS recommendation of best starting point for success in health professional study i.e. 'CertHSc' (Certificate in Health Sciences, bridging/foundation), 'Bachelor' (degree-level) or 'Not FMHS' (Faculty of Medical and Health Sciences). Regression analyses controlled for interview year, gender and ancestry. Of the 918 MAPAS interviewees: 35% (319) were Māori, 58% (530) Pacific, 7% (68) Māori/Pacific; 71% (653) school leavers; 72% (662) females. The average rank score was 167/320, 40-80 credits below guaranteed FMHS degree offers. Just under half of all interviewees were recommended 'CertHSc' 47% (428), 13% (117) 'Bachelor' and 38% (332) 'Not FMHS' as the best starting point. Strong associations were identified between Bachelor recommendation and exposure to Any 2 Sciences (OR:7.897, CI:3.855-16.175; p < 0.0001), higher rank score (OR:1.043, CI:1.034-1.052; p < 0.0001) and higher scores on MAPAS mathematics test (OR:1.043, CI:1.028-1.059; p < 0.0001). MMI stations had mixed associations, with academic preparation and career aspirations more consistently associated with recommendations. Our findings raise concerns about the ability of the secondary education sector to prepare Māori and Pacific students adequately for health professional study

PA12 Is digital storytelling ka pai for new zealand māori? using digital storytelling as a method to explore whānau end of life caregiving experiences: a pilot study.

PubMed

Williams, Lisa; Moeke-Maxwell, Tess; Kothari, Shuchi; Pearson, Sarina; Gott, Merryn; Black, Stella; Frey, Rosemary; Wharemate, Rawiri; Hansen, Whio

2015-04-01

Māori regard stories as a preferred method for imparting knowledge through waiata (song), moteatea (poetry), kauwhau (moralistic tale), pakiwaitara (story) and purakau (myths). Storytelling is also an expression of tinorangatiratanga (self-determination); Māori have the right to manage their knowledge, which includes embodiment in forms transcending typical western formulations. Digital storytelling is a process by which 'ordinary people' create short autobiographical videos. It has found application in numerous disciplines including public health and has been used to articulatethe experiences of those often excluded from knowledge production. To explore the use of digital storytelling as a research method for learning about whānau (family) experiences providing end of life care for kaumātua (older people). Eight Māori and their nominated co-creators attended a three-day digital story telling workshop led by co-researchers Shuchi Kothari and Sarina Pearson. They were guided in the creation of first-person digital stories about caring for kaumātua. The videos were shared at a group screening, and participants completed questionnaires about the workshop and their videos. A Kaupapa Māori narrative analysis was applied to their stories to gain new perspectives on Māori end of life caregiving practices. (Kaupapa Maori research privileges Maori worldviews and indigenous knowledge systems.) Digital storytelling is an appropriate method as Māori is an oral/aural society. It allows Māori to share their stories with others, thus promoting community support at the end of life, befitting a public health approach. Digital storytelling can be a useful method for Māori to express their experiences providing end of life caregiving. © 2015, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Extreme Asymmetry in the Polarized Disk of V1247 Orionis

NASA Technical Reports Server (NTRS)

Ohta, Yurina; Fukagawa, Misato; Sitko, Michael; Muto, Takayuki; Kraus, Stefan; Grady, Carol A.; Wisniewski, John A.; Swearingen, Jeremy R.; Shibai, Hiroshi; McElwain, Michael W.

2016-01-01

We present the first near-infrared scattered-light detection of the transitional disk around V1247 Ori, which was obtained using high-resolution polarimetric differential imaging observations with Subaru/HiCIAO. Our imaging in the H band reveals the disk morphology at separations of approx.0.14-0.86 (54-330 au) from the central star. The polarized intensity image shows a remarkable arc-like structure toward the southeast of the star, whereas the fainter northwest region does not exhibit any notable features. The shape of the arm is consistent with an arc of 0.28 +/- 0.09 in radius (108 au from the star), although the possibility of a spiral arm with a small pitch angle cannot be excluded. V1247 Ori features an exceptionally large azimuthal contrast in scattered, polarized light; the radial peak of the southeastern arc is about three times brighter than the northwestern disk measured at the same distance from the star. Combined with the previous indication of an inhomogeneous density distribution in the gap at 46 au, the notable asymmetry in the outer disk suggests the presence of unseen companions and/or planet-forming processes ongoing in the arc.

A Disulfide Bond-forming Machine Is Linked to the Sortase-mediated Pilus Assembly Pathway in the Gram-positive Bacterium Actinomyces oris.

PubMed

Reardon-Robinson, Melissa E; Osipiuk, Jerzy; Chang, Chungyu; Wu, Chenggang; Jooya, Neda; Joachimiak, Andrzej; Das, Asis; Ton-That, Hung

2015-08-28

Export of cell surface pilins in Gram-positive bacteria likely occurs by the translocation of unfolded precursor polypeptides; however, how the unfolded pilins gain their native conformation is presently unknown. Here, we present physiological studies to demonstrate that the FimA pilin of Actinomyces oris contains two disulfide bonds. Alanine substitution of cysteine residues forming the C-terminal disulfide bridge abrogates pilus assembly, in turn eliminating biofilm formation and polymicrobial interaction. Transposon mutagenesis of A. oris yielded a mutant defective in adherence to Streptococcus oralis, and revealed the essential role of a vitamin K epoxide reductase (VKOR) gene in pilus assembly. Targeted deletion of vkor results in the same defects, which are rescued by ectopic expression of VKOR, but not a mutant containing an alanine substitution in its conserved CXXC motif. Depletion of mdbA, which encodes a membrane-bound thiol-disulfide oxidoreductase, abrogates pilus assembly and alters cell morphology. Remarkably, overexpression of MdbA or a counterpart from Corynebacterium diphtheriae, rescues the Δvkor mutant. By alkylation assays, we demonstrate that VKOR is required for MdbA reoxidation. Furthermore, crystallographic studies reveal that A. oris MdbA harbors a thioredoxin-like fold with the conserved CXXC active site. Consistently, each MdbA enzyme catalyzes proper disulfide bond formation within FimA in vitro that requires the catalytic CXXC motif. Because the majority of signal peptide-containing proteins encoded by A. oris possess multiple Cys residues, we propose that MdbA and VKOR constitute a major folding machine for the secretome of this organism. This oxidative protein folding pathway may be a common feature in Actinobacteria. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

A Disulfide Bond-forming Machine Is Linked to the Sortase-mediated Pilus Assembly Pathway in the Gram-positive Bacterium Actinomyces oris*

PubMed Central

Reardon-Robinson, Melissa E.; Osipiuk, Jerzy; Chang, Chungyu; Wu, Chenggang; Jooya, Neda; Joachimiak, Andrzej; Das, Asis; Ton-That, Hung

2015-01-01

Export of cell surface pilins in Gram-positive bacteria likely occurs by the translocation of unfolded precursor polypeptides; however, how the unfolded pilins gain their native conformation is presently unknown. Here, we present physiological studies to demonstrate that the FimA pilin of Actinomyces oris contains two disulfide bonds. Alanine substitution of cysteine residues forming the C-terminal disulfide bridge abrogates pilus assembly, in turn eliminating biofilm formation and polymicrobial interaction. Transposon mutagenesis of A. oris yielded a mutant defective in adherence to Streptococcus oralis, and revealed the essential role of a vitamin K epoxide reductase (VKOR) gene in pilus assembly. Targeted deletion of vkor results in the same defects, which are rescued by ectopic expression of VKOR, but not a mutant containing an alanine substitution in its conserved CXXC motif. Depletion of mdbA, which encodes a membrane-bound thiol-disulfide oxidoreductase, abrogates pilus assembly and alters cell morphology. Remarkably, overexpression of MdbA or a counterpart from Corynebacterium diphtheriae, rescues the Δvkor mutant. By alkylation assays, we demonstrate that VKOR is required for MdbA reoxidation. Furthermore, crystallographic studies reveal that A. oris MdbA harbors a thioredoxin-like fold with the conserved CXXC active site. Consistently, each MdbA enzyme catalyzes proper disulfide bond formation within FimA in vitro that requires the catalytic CXXC motif. Because the majority of signal peptide-containing proteins encoded by A. oris possess multiple Cys residues, we propose that MdbA and VKOR constitute a major folding machine for the secretome of this organism. This oxidative protein folding pathway may be a common feature in Actinobacteria. PMID:26170452

Pathogenicity of exopolysaccharide-producing Actinomyces oris isolated from an apical abscess lesion

PubMed Central

Yamane, K; Nambu, T; Yamanaka, T; Ishihara, K; Tatami, T; Mashimo, C; Walker, C B; Leung, K-P; Fukushima, H

2013-01-01

Aim To demonstrate a capacity for producing exopolysaccharides (EPSs) and an ability to form biofilm on abiotic materials of Actinomyces oris strain K20. Methodology The productivity of EPSs and the ability to form biofilm of strain K20 were evaluated by measuring viscosity of spent culture media and by scanning electron microscopy (SEM) and the biofilm assay on microtitre plates, respectively. High-performance liquid chromatography was used to determine the chemical composition of the viscous materials. To examine the role of the viscous materials attributable to the pathogenicity in this organism, the ability of strain K20 to induce abscess formation was compared in mice to that of ATCC 27044. Results The viscosity of the spent culture media of K20 was significantly higher than that of ATCC 27044. Strain K20 showed dense meshwork structures around the cells and formed biofilms on microtitre plates, whereas ATCC 27044 did not. Chemical analysis of the viscous materials revealed that they were mainly composed of neutral sugars with mannose constituting 77.5% of the polysaccharides. Strain K20 induced persistent abscesses in mice lasting at least 5 days at a concentration of 108 cells mL−1, whereas abscesses induced by ATCC 27044 healed and disappeared or decreased in size at day 5. Conclusions Strain K20 produced EPSs, mainly consisting of mannose, and formed biofilms. This phenotype might play an important role for A. oris to express virulence through the progression of apical periodontitis. PMID:22900599

Pathogenicity of exopolysaccharide-producing Actinomyces oris isolated from an apical abscess lesion.

PubMed

Yamane, K; Nambu, T; Yamanaka, T; Ishihara, K; Tatami, T; Mashimo, C; Walker, C B; Leung, K-P; Fukushima, H

2013-02-01

To demonstrate a capacity for producing exopolysaccharides (EPSs) and an ability to form biofilm on abiotic materials of Actinomyces oris strain K20. The productivity of EPSs and the ability to form biofilm of strain K20 were evaluated by measuring viscosity of spent culture media and by scanning electron microscopy (SEM) and the biofilm assay on microtitre plates, respectively. High-performance liquid chromatography was used to determine the chemical composition of the viscous materials. To examine the role of the viscous materials attributable to the pathogenicity in this organism, the ability of strain K20 to induce abscess formation was compared in mice to that of ATCC 27044. The viscosity of the spent culture media of K20 was significantly higher than that of ATCC 27044. Strain K20 showed dense meshwork structures around the cells and formed biofilms on microtitre plates, whereas ATCC 27044 did not. Chemical analysis of the viscous materials revealed that they were mainly composed of neutral sugars with mannose constituting 77.5% of the polysaccharides. Strain K20 induced persistent abscesses in mice lasting at least 5 days at a concentration of 10(8) cells mL(-1), whereas abscesses induced by ATCC 27044 healed and disappeared or decreased in size at day 5. Strain K20 produced EPSs, mainly consisting of mannose, and formed biofilms. This phenotype might play an important role for A. oris to express virulence through the progression of apical periodontitis. © 2012 International Endodontic Journal.

Spectral characterization of V-type asteroids: are all the basaltic objects coming from Vesta?

NASA Astrophysics Data System (ADS)

Ieva, S.; Fulvio, D.; Dotto, E.; Lazzaro, D.; Perna, D.; Strazzulla, G.; Fulchignoni, M.

In the last twenty-five years several small basaltic V-type asteroids have been identified all around the main belt. Most of them are members of the Vesta dynamical family, but an increasingly large number appear to have no link with it. The question that arises is whether all these basaltic objects do indeed come from Vesta. In the light of the Dawn mission, who visited Vesta in 2011-2012, recent works were dedicated to the observation of several new V-type asteroids and their comparison with laboratory data (Fulvio et al., \\cite{Fulvio2015}), and to a statistical analysis of the spectroscopic and mineralogical properties of the largest sample of V-types ever collected (Ieva et al., \\cite{Ieva2015}, with the objective to highlight similarities and differences among objects belonging and not belonging to the Vesta dynamical family. Laboratory experiments support the idea that V-type NEAs spectral properties could be due to a balance of space weathering and rejuvenation processes triggered by close encounters with terrestrial planets. Statistical analysis shows that although most of the V-type asteroids in the inner main belt do have a surface composition compatible with Vesta family members, this seem not to be the case for V-types in the middle and outer main belt. For these Middle and Outer V-types (MOVs), their sizes, spectral parameters and location far away from the Vesta dynamical region point to a different origin than Vesta.

The relationship between socially-assigned ethnicity, health and experience of racial discrimination for Māori: analysis of the 2006/07 New Zealand Health Survey

PubMed Central

2013-01-01

Background In New Zealand, there are significant and long-standing inequalities in a range of health outcomes, risk factors and healthcare measures between Māori (indigenous peoples) and Pākehā (European). This study expands our understanding of racism as a determinant of such inequalities to examine the concept of socially-assigned ethnicity (how an individual is classified by others ethnically/racially) and its relationship to health and racism for Māori. There is some evidence internationally that being socially-assigned as the dominant ethnic group (in this case European) offers health advantage. Methods We analysed data from the 2006/07 New Zealand Health Survey for adult participants who self-identified their ethnicity as Māori (n = 3160). The association between socially-assigned ethnicity and individual experience of racial discrimination, and socially-assigned ethnicity and health (self-rated health, psychological distress [Kessler 10-item scale]) was assessed using logistic and linear regression analyses, respectively. Results Māori who were socially-assigned as European-only had significantly lower experience of racial discrimination (adjusted odds ratio [OR] = 0.58, 95% confidence interval [CI] = 0.44, 0.78) than Māori who were socially-assigned as non-European. Being socially-assigned as European-only was also associated with health advantage compared to being socially-assigned non-European: more likely to respond with self-rated very good/excellent health (age, sex adjusted OR = 1.39, 95% CI = 1.10, 1.74), and lower Kessler 10 scores (age, sex adjusted mean difference = -0.66, 95% C I = -1.22, -0.10). These results were attenuated following adjustment for socioeconomic measures and experience of racial discrimination. Conclusions Results suggest that, in a race conscious society, the way people’s ethnicities are viewed by others is associated with tangible health risk or advantage, and this is consistent with an

DM ORI: A YOUNG STAR OCCULTED BY A DISTURBANCE IN ITS PROTOPLANETARY DISK

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodriguez, Joseph E.; Stassun, Keivan G.; Lund, Michael B.

In some planet formation theories, protoplanets grow gravitationally within a young star’s protoplanetary disk, a signature of which may be a localized disturbance in the disk’s radial and/or vertical structure. Using time-series photometric observations by the Kilodegree Extremely Little Telescope South project and the All-Sky Automated Survey for SuperNovae, combined with archival observations, we present the discovery of two extended dimming events of the young star, DM Ori. This young system faded by ∼1.5 mag from 2000 March to 2002 August and then again in 2013 January until 2014 September (depth ∼1.7 mag). We constrain the duration of the 2000–2002more » dimming to be < 860 days, and the event in 2013–2014 to be < 585 days, separated by ∼12.5 years. A model of the spectral energy distribution indicates a large infrared excess consistent with an extensive circumstellar disk. Using basic kinematic arguments, we propose that DM Ori is likely being periodically occulted by a feature (possibly a warp or perturbation) in its circumstellar disk. In this scenario, the occulting feature is located >6 au from the host star, moving at ∼14.6 km s{sup −1} and is ∼4.9 au in width. This localized structure may indicate a disturbance such as that which may be caused by a protoplanet early in its formation.« less

Quantitative analysis of a Māori and Pacific admission process on first-year health study.

PubMed

Curtis, Elana; Wikaire, Erena; Jiang, Yannan; McMillan, Louise; Loto, Robert; Airini; Reid, Papaarangi

2015-11-03

Universities should provide flexible and inclusive selection and admission policies to increase equity in access and outcomes for indigenous and ethnic minority students. This study investigates an equity-targeted admissions process, involving a Multiple Mini Interview and objective testing, advising Māori and Pacific students on their best starting point for academic success towards a career in medicine, nursing, health sciences and pharmacy. All Māori and Pacific Admission Scheme (MAPAS) interviewees enrolled in bridging/foundation or degree-level programmes at the University of Auckland were identified (2009 to 2012). Generalised linear regression models estimated the predicted effects of admission variables (e.g. MAPAS Maths Test; National Certificate in Educational Achievement (NCEA) Rank Score; Any 2 Sciences; Followed MAPAS Advice) on first year academic outcomes (i.e. Grade Point Average (GPA) and Passes All Courses) adjusting for MAPAS interview year, gender, ancestry and school decile. 368 First Year Tertiary (bridging/foundation or degree-level) and 242 First Year Bachelor (degree-level only) students were investigated. NCEA Rank Score (estimate 0.26, CI: 0.18-0.34, p< 0.0001); MAPAS Advice Followed (1.26, CI: 0.18-1.34, p = 0.0002); Exposure to Any 2 Sciences (0.651, CI: 0.15-1.15, p = 0.012); and MAPAS Mathematics Test (0.14, CI: 0.02-0.26, p = 0.0186) variables were strongly associated with an increase in First Year Tertiary GPA. The odds of passing all courses in First Year Tertiary study was 5.4 times higher for students who Followed MAPAS Advice (CI: 2.35-12.39; p< 0.0001) and 2.3 times higher with Exposure to Any Two Sciences (CI: 1.15-4.60; p = 0.0186). First Year Bachelor students who Followed MAPAS Advice had an average GPA that was 1.1 points higher for all eight (CI: 0.45-1.73; p = 0.0009) and Core 4 courses (CI: 0.60-2.04; p = 0.0004). The MAPAS admissions process was strongly associated with positive academic

Whakawhiti Kōrero, a Method for the Development of a Cultural Assessment Tool, Te Waka Kuaka, in Māori Traumatic Brain Injury.

PubMed

Elder, Hinemoa; Kersten, Paula

2015-01-01

The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI) in Māori proposes that a culturally defined injury occurs in tandem with the physical injury. A cultural response is therefore indicated. This research investigates a Māori method used in the development of cultural needs assessment tool designed to further examine needs associated with the culturally determined injury and in preparation for formal validation. Whakawhiti kōrero is a method used to develop better statements in the development of the assessment tool. Four wānanga (traditional fora) were held including one with whānau (extended family) with experience of traumatic brain injury. The approach was well received. A final version, Te Waka Kuaka, is now ready for validation. Whakawhiti kōrero is an indigenous method used in the development of cultural needs assessment tool in Māori traumatic brain injury. This method is likely to have wider applicability, such as Mental Health and Addictions Services, to ensure robust process of outcome measure and needs assessment development.

Widening participation of Māori and Pasifika students in health careers: evaluation of two health science academies.

PubMed

Middleton, Lesley; Tanuvasa, Ausaga Faasalele; Pledger, Megan; Grace, Nicola; Smiler, Kirsten; Loto-Su'a, Tua Taueetia; Cumming, Jacqueline

2018-05-24

Objective The aim of the present study was to evaluate the short-term outcomes of two health science academies established by a district health board in South Auckland, New Zealand, to create a health workforce pipeline for local Māori and Pasifika students. Methods A mixed-methods approach was used, involving background discussions with key informants to generate an initial logic model of how the academies work, followed by secondary analysis of students' records relating to retention and academic achievement, a survey of senior academy students' interest in particular health careers and face-to-face interviews and focus groups with students, families and teachers. Results Academy students are collectively achieving better academic results than their contemporaries, although selection decisions are likely to contribute to these results. Academies are retaining students, with over 70% of students transitioning from Year 11 to Years 12 and 13. Senior students are expressing long-term ambitions to work in the health sector. Conclusions Health science academies show promise as an innovative approach to supporting Māori and Pasifika students prepare for a career in the health professions. Evaluating the long-term outcomes of the academies is required to determine their contribution to addressing inequities in the local health workforce. What is known about the topic? Despite progress in health workforce participation for underrepresented indigenous and ethnic minority groups in New Zealand, significant disparities persist. Within this context, a workforce development pipeline that targets preparation of secondary school students is recommended to address identified barriers in the pursuit of health careers. What does this paper add? We provide an evaluation of an innovative district health board initiative supporting high school students that is designed to ensure their future workforce is responsive to the needs of the local community. What are the implications for

Detection of orbicularis oris muscle defects in first degree relatives of cleft lip children using ultrasound.

PubMed

Mittal, M; Maheshwari, N; Ahlawat, K; Sharma, V; Sultan, A; Chopra, R

2012-01-01

The severity of cleft lip (CL) varies considerably from complete bilateral CL and palate at one end of the spectrum to a minimal CL at the other. In some cases of microform clefting, there may be no visible manifestation of the defect on the lip surface (i.e., the defect is occult) and no residual functional deficit. This study used high resolution ultrasonography to detect subclinical anomalies of orbicularis oris muscle (OOM) in first degree relatives of CL +- cleft palate children and compared it with controls. Thirty relatives of 25 children with non-syndromic CL or CL+ CP were identified for the study. Thirty subjects having negative family history of CL/P in three generations and absence of any minimal cleft features were taken as controls. Ultrasound scans of OOM of all the controls and relatives were taken. Statistical analysis was performed using standard χ2 tests with Yates correction. Defects were seen in 13.3% of relatives and no defects were seen in controls, this was not statistically significant. The data support the hypothesis that subclinical CL cases with subepithelial OOM defects do exist and Orbicularis oris discontinuities represent the mildest form of CL.

A Widespread, Clumpy Starburst in the Isolated Ongoing Dwarf Galaxy Merger dm1647+21

DOE Office of Scientific and Technical Information (OSTI.GOV)

Privon, G. C.; Stierwalt, S.; Johnson, K. E.

Interactions between pairs of isolated dwarf galaxies provide a critical window into low-mass hierarchical, gas-dominated galaxy assembly and the build-up of stellar mass in low-metallicity systems. We present the first Very Large Telescope/Multi Unit Spectroscopic Explorer (VLT/MUSE) optical integral field unit (IFU) observations of the interacting dwarf pair dm1647+21 selected from the TiNy Titans survey. The H α emission is widespread and corresponds to a total unobscured star formation rate (SFR) of 0.44 M {sub ⊙} yr{sup −1}, which is 2.7 times higher than the SFR inferred from Sloan Digital Sky Survey (SDSS) data. The implied specific SFR (sSFR) formore » the system is elevated by more than an order of magnitude above non-interacting dwarfs in the same mass range. This increase is dominated by the lower-mass galaxy, which has a sSFR enhancement of >50. Examining the spatially resolved maps of classic optical line diagnostics, we find that the interstellar medium (ISM) excitation can be fully explained by star formation. The velocity field of the ionized gas is not consistent with simple rotation. Dynamical simulations indicate that the irregular velocity field and the stellar structure is consistent with the identification of this system as an ongoing interaction between two dwarf galaxies. The widespread, clumpy enhancements in the star formation in this system point to important differences in the effect of mergers on dwarf galaxies, compared to massive galaxies; rather than the funneling of gas to the nucleus and giving rise to a nuclear starburst, starbursts in low-mass galaxy mergers may be triggered by large-scale ISM compression, and thus may be more distributed.« less

VizieR Online Data Catalog: Light curves of Algol-type binaries. VI. FR Ori (Yang+, 2014)

NASA Astrophysics Data System (ADS)

Yang, Y.-G.; Wei, J.-Y.; Li, H.-L.

2014-09-01

New photometry of FR Ori was performed in 2012 November (Nov 7-8 and Nov 16-20) and December (Dec 5-9), using the 60cm telescope at the Xinglong Station (XLs) of the National Astronomical Observatories of China (NAOC). A Princeton Instrument 1024*1024 CCD camera was mounted at this telescope. The standard Johnson/Cousins set of BVIR filters was applied. (3 data files).

"Ode Ori": a culture-bound disorder with prominent somatic features in Yoruba Nigerian patients.

PubMed

Makanjuola, R O

1987-03-01

Thirty patients diagnosed by Nigerian Yoruba traditional healers as suffering from a condition termed "Ode Ori" are described. The chief complaints were of a crawling sensation in the head and body, noises in the ears, palpitations and various other somatic complaints. Anxiety and depressive symptoms were prominent in all the patients and indeed the most common DSM-III diagnoses were of depressive and anxiety disorders. The significance of the disorder and its features is discussed in the context of the socio-cultural background of the patients.

The Protective Influence of Family Connectedness, Ethnic Identity, and Ethnic Engagement for New Zealand Ma¯ori Adolescents

ERIC Educational Resources Information Center

Stuart, Jaimee; Jose, Paul E.

2014-01-01

The present study examined the associations among family connectedness, ethnic identity, and ethnic engagement on changes in well-being over time for the understudied population of Ma¯ori (indigenous New Zealand) youth. Data were collected as part of a longitudinal study of youth connectedness in New Zealand using self-report measures at 3…

Title V Permit Objection Communication Strategy

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Inhibition of polyomavirus ori-dependent DNA replication by mSin3B.

PubMed

Xie, An-Yong; Folk, William R

2002-12-01

When tethered in cis to DNA, the transcriptional corepressor mSin3B inhibits polyomavirus (Py) ori-dependent DNA replication in vivo. Histone deacetylases (HDACs) appear not to be involved, since tethering class I and class II HDACs in cis does not inhibit replication and treating the cells with trichostatin A does not specifically relieve inhibition by mSin3B. However, the mSin3B L59P mutation that impairs mSin3B interaction with N-CoR/SMRT abrogates inhibition of replication, suggesting the involvement of N-CoR/SMRT. Py large T antigen interacts with mSin3B, suggesting an HDAC-independent mechanism by which mSin3B inhibits DNA replication.

Dramatic Evolution of the Disk-Shaped Secondary in the Orion Trapezium Star θ1 Ori B1 (BM Ori): MOST Satellite Observations

NASA Astrophysics Data System (ADS)

Windemuth, Diana; Herbst, W.; Tingle, E. D.; Fuechsl, R.; Kilgard, R. E.; Pinette, M.; Templeton, M. R.; Henden, A. A.

2013-01-01

θ1 Orionis B1 (BM Ori), the faintest of four well-known Trapezium stars in Orion, is the youngest known eclipsing binary system with a contraction age < 105 years. While the primary is a B3 star, the secondary component 2M⊙ based on radial velocities) has eluded classification since the duration and shape of the eclipse do not conform to those of an ordinary star. We report nearly continuous photometric observations obtained with the Microvariability & Oscillations of STars (MOST) satellite over ~4 cycles of the 6.47d binary period, which contain both primary and secondary eclipses, as well as a clear reflection effect. We find that the shape of the primary light curve has evolved significantly over the past 40 years. While its overall duration and depth have remained constant, ingress and egress are notably shallower now, and the flat bottom that has distinguished BM Ori’s light curve in the past is ill defined or even absent in the most recent data. Furthermore, small perturbations, some of which are repeated over the four cycles monitored, indicate semi-stable structures outside the Robe lobe of the secondary. In addition, we re-examine data from the Chandra Orion Ultradeep Project (COUP) study and detect the primary eclipse at X-ray wavelengths. The optical light curve continues to be well modeled by a self-luminous and reflective disk-shaped object seen nearly edge-on, orbiting a normal ZAMS primary. We treat the change in shape over the past four decades as an opacity variation in a tenuous outer envelope or disk surrounding the secondary, perhaps related to the digestion of accreted matter over the last 50-100 years. This work was partially funded by the NASA ROSES program and NASA’s Origins of Solar Systems program. Undergraduate participation in this research was supported by NSF/REU grants in support of Wesleyan University as a part of the Keck Northeast Astronomy Consortium.

From object to subject: hybrid identities of indigenous women in science

NASA Astrophysics Data System (ADS)

McKinley, Elizabeth

2008-12-01

The use of hybridity today suggests a less coherent, unified and directed process than that found in the Enlightenment science's cultural imperialism, but regardless of this neither concept exists outside power and inequality. Hence, hybridity raises the question of the terms of the mixture and the conditions of mixing. Cultural hybridity produced by colonisation, under the watchful eye of science at the time, and the subsequent life in a modern world since does not obscure the power that was embedded in the moment of colonisation. Indigenous identities are constructed within and by cultural power. While we all live in a global society whose consequences no one can escape, we remain unequal participants and globalisation remains an uneven process. This article argues that power has become a constitutive element in our own hybrid identities in indigenous people's attempts to participate in science and science education. Using the indigenous peoples of Aotearoa New Zealand (called Māori) as a site of identity construction, I argue that the move from being the object of science to the subject of science, through science education in schools, brings with it traces of an earlier meaning of `hybridity' that constantly erupts into the lives of Māori women scientists.

Comparison of metamotivational dominance and cultural identity between Japanese National Team and Māori All Blacks rugby players.

PubMed

Kuroda, Yusuke; Palmer, Farah; Nakazawa, Makoto

2017-11-01

This pilot study used a reversal theory framework to examine metamotivational dominance of rugby players on the Māori All Blacks (MABs) squad of New Zealand and the Japanese National Team (JNT). Since the two groups have different cultural team demographics, cultural identity was also examined. Twenty six players from the MABs and 31 from the JNT completed questionnaires on metamotivational dominance and cultural identity. In terms of metamotivational dominance, the findings indicated that the MABs were more playful minded and spontaneous oriented than the JNT. Regarding cultural identity, the JNT showed a greater knowledge of their own culture and higher comfort level in their cultural context, while the MABs felt more positive and willing to sustain their own culture. The motivational personality differences between the teams may reflect the style of play that is valued within each team culture that is, flair, spontaneity and high-risk play within Māori rugby, and structure, team unity and conformity within the JNT. This suggests that metamotivational dominance of teams and players is influenced by the cultural identity of both the individuals and the group, which may have a further impact on team cohesion and performance.

The Undiscovered Country: How Many Low-Delta-V Near-Earth Objects Remain to be Found?

NASA Astrophysics Data System (ADS)

Elvis, Martin; Ranjan, Sukrit; Galache, Jose Luis

2014-11-01

Low delta-v near-Earth objects (NEOs) are of great interest as targets for science and human missions, for possible retrieval to cis-lunar space and as potential resource targets for both exploration and commercial uses. This interest stems from the exponential nature of the rocket equation that imposes a harsh mass penalty on any mission to a higher delta-v. We have compared the known NEO population from the IAU Minor Planet Center (MPC) with the NEOSSat-1 model residence times for the NEO population (Greenstreet & Gladman, 2012) to assess how many undiscovered NEOs there are as a function of H magnitude and delta-v. We find that the median of known NEOs is at lower delta-v (7.3 km/s) than the model population (9.8 km/s), suggesting a bias toward detecting lower delta-v NEOs. To the precision of our data, which is as low as 40% for the 300-500 m diameter (D) objects, the bulk of the larger D>300 m NEOs have been found from delta-v<10.3 km/s. However in the 50 < D < 300 m range there are tens of thousands of delta-v < 10.3 km/s to be found. We examine the total number of undiscovered NEOs as a function of delta-v and find that to find at least 100 now unknown NEOs requires a threshold delta-v of 5.7 km/s, while to find at least 1000 of them requires a threshold delta-v of 6.2 km/s. These numbers can be used to determine mission delta-v requirements for a given number of suitable targets, that will likely be restricted by other criteria (size, composition, spin state) to a few percent of the total population.

Radio emission of cataclysmic variable stars

NASA Technical Reports Server (NTRS)

Fuerst, E.; Benz, A.; Hirth, W.; Geffert, M.; Kiplinger, A.

1986-01-01

Eight cataclysmic variable stars were observed at 6 cm wavelength using the Very Large Array (VLA). The objects were: CN-Ori, SS-Aur, YZ-Cnc, SU-Uma, Z-Cam, V603-Aql, EM-Cyg, and RZ-Sge. Most of these objects were in optical high stage, but none were detected beyond flux limits between 0.1 and 0.3 mJy.

Lethality of Sortase Depletion in Actinomyces oris Caused by Excessive Membrane Accumulation of a Surface Glycoprotein

PubMed Central

Wu, Chenggang; Huang, I-Hsiu; Chang, Chungyu; Reardon-Robinson, Melissa Elizabeth; Das, Asis; Ton-That, Hung

2014-01-01

Sortase, a cysteine-transpeptidase conserved in Gram-positive bacteria, anchors on the cell wall many surface proteins that facilitate bacterial pathogenesis and fitness. Genetic disruption of the housekeeping sortase in several Gram-positive pathogens reported thus far attenuates virulence, but not bacterial growth. Paradoxically, we discovered that depletion of the housekeeping sortase SrtA was lethal for Actinomyces oris; yet, all of its predicted cell wall-anchored protein substrates (AcaA-N) were individually dispensable for cell viability. Using Tn5-transposon mutagenesis to identify factors that upend lethality of srtA deletion, we uncovered a set of genetic suppressors harboring transposon insertions within genes of a locus encoding AcaC and a LytR-CpsA-Psr (LCP)-like protein. AcaC was shown to be highly glycosylated and dependent on LCP for its glycosylation. Upon SrtA depletion, the glycosylated form of AcaC, hereby renamed GspA, was accumulated in the membrane. Overexpression of GspA in a mutant lacking gspA and srtA was lethal; conversely, cells overexpressing a GspA mutant missing a membrane-localization domain were viable. The results reveal a unique glycosylation pathway in A. oris that is coupled to cell wall anchoring catalyzed by sortase SrtA. Significantly, this novel phenomenon of glyco-stress provides convenient cell-based assays for developing a new class of inhibitors against Gram-positive pathogens. PMID:25230351

A Type I Signal Peptidase Is Required for Pilus Assembly in the Gram-Positive, Biofilm-Forming Bacterium Actinomyces oris

PubMed Central

Siegel, Sara D.

2016-01-01

ABSTRACT The Gram-positive bacterium Actinomyces oris, a key colonizer in the development of oral biofilms, contains 18 LPXTG motif-containing proteins, including fimbrillins that constitute two fimbrial types critical for adherence, biofilm formation, and polymicrobial interactions. Export of these protein precursors, which harbor a signal peptide, is thought to be mediated by the Sec machine and require cleavage of the signal peptide by type I signal peptidases (SPases). Like many Gram-positive bacteria, A. oris expresses two SPases, named LepB1 and LepB2. The latter has been linked to suppression of lethal “glyco-stress,” caused by membrane accumulation of the LPXTG motif-containing glycoprotein GspA when the housekeeping sortase srtA is genetically disrupted. Consistent with this finding, we show here that a mutant lacking lepB2 and srtA was unable to produce high levels of glycosylated GspA and hence was viable. However, deletion of neither lepB1 nor lepB2 abrogated the signal peptide cleavage and glycosylation of GspA, indicating redundancy of SPases for GspA. In contrast, the lepB2 deletion mutant failed to assemble the wild-type levels of type 1 and 2 fimbriae, which are built by the shaft fimbrillins FimP and FimA, respectively; this phenotype was attributed to aberrant cleavage of the fimbrillin signal peptides. Furthermore, the lepB2 mutants, including the catalytically inactive S101A and K169A variants, exhibited significant defects in polymicrobial interactions and biofilm formation. Conversely, lepB1 was dispensable for the aforementioned processes. These results support the idea that LepB2 is specifically utilized for processing of fimbrial proteins, thus providing an experimental model with which to study the basis of type I SPase specificity. IMPORTANCE Sec-mediated translocation of bacterial protein precursors across the cytoplasmic membrane involves cleavage of their signal peptide by a signal peptidase (SPase). Like many Gram

A Type I Signal Peptidase Is Required for Pilus Assembly in the Gram-Positive, Biofilm-Forming Bacterium Actinomyces oris.

PubMed

Siegel, Sara D; Wu, Chenggang; Ton-That, Hung

2016-08-01

The Gram-positive bacterium Actinomyces oris, a key colonizer in the development of oral biofilms, contains 18 LPXTG motif-containing proteins, including fimbrillins that constitute two fimbrial types critical for adherence, biofilm formation, and polymicrobial interactions. Export of these protein precursors, which harbor a signal peptide, is thought to be mediated by the Sec machine and require cleavage of the signal peptide by type I signal peptidases (SPases). Like many Gram-positive bacteria, A. oris expresses two SPases, named LepB1 and LepB2. The latter has been linked to suppression of lethal "glyco-stress," caused by membrane accumulation of the LPXTG motif-containing glycoprotein GspA when the housekeeping sortase srtA is genetically disrupted. Consistent with this finding, we show here that a mutant lacking lepB2 and srtA was unable to produce high levels of glycosylated GspA and hence was viable. However, deletion of neither lepB1 nor lepB2 abrogated the signal peptide cleavage and glycosylation of GspA, indicating redundancy of SPases for GspA. In contrast, the lepB2 deletion mutant failed to assemble the wild-type levels of type 1 and 2 fimbriae, which are built by the shaft fimbrillins FimP and FimA, respectively; this phenotype was attributed to aberrant cleavage of the fimbrillin signal peptides. Furthermore, the lepB2 mutants, including the catalytically inactive S101A and K169A variants, exhibited significant defects in polymicrobial interactions and biofilm formation. Conversely, lepB1 was dispensable for the aforementioned processes. These results support the idea that LepB2 is specifically utilized for processing of fimbrial proteins, thus providing an experimental model with which to study the basis of type I SPase specificity. Sec-mediated translocation of bacterial protein precursors across the cytoplasmic membrane involves cleavage of their signal peptide by a signal peptidase (SPase). Like many Gram-positive bacteria, A. oris expresses

The rotation of very low mass objects

NASA Astrophysics Data System (ADS)

Scholz, Alexander

2004-10-01

This dissertation contains an investigation of the rotation of very low mass objects, i.e. Brown Dwarfs and stars with masses <0.4 MS. Today, it is well-established that there are large populations of such VLM objects in open clusters and in the field, but our knowledge about their physical properties and evolution is still very limited. Contrary to their solar-mass siblings, VLM objects are fully convective throughout their evolution. Thus, they are not able to form a large-scale magnetic field like for example the sun. The magnetic field, in turn, is crucial for the regulation of rotation: Magnetic interaction between star and circumstellar disk ("disk-locking") and angular momentum losses through stellar winds have dominant influence on the rotational evolution. Thus, we can expect major differences in the rotational behaviour of VLM objects and solar-mass stars. The best method to investigate stellar rotation is to measure rotation periods. If a star exhibits surface features which are asymmetrically distributed, its brightness may be modulated with the rotation period. Thus, this dissertation is based on the analysis of photometric time series. Open clusters are an ideal environment for such a project, since they enable one to follow many objects at the same time. Additionally, they allow one to investigate the age and mass dependence of rotation, because distance and age of the clusters are known in good approximation. For this thesis, five open clusters were observed, which span an age range from 3 to 750 Myr. In three of them (SigmaOri, EpsilonOri, IC4665), VLM objects were identified by means of colour magnitude diagrams. The candidate lists for these three regions comprise at least 100 objects, for which photometry in at least three wavelength bands is available. About a fifth to a third of these candidates could be contaminating field stars in the fore- or background of the clusters. For the remaining two clusters (Pleiades and Praesepe), objects from

STRUCTURED JETS IN BL LAC OBJECTS: EFFICIENT PeV NEUTRINO FACTORIES?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tavecchio, Fabrizio; Ghisellini, Gabriele; Guetta, Dafne

2014-09-20

The origin of high-energy neutrinos (0.1–1 PeV range) detected by IceCube remains a mystery. In this work, we explore the possibility that efficient neutrino production can occur in structured jets of BL Lac objects, characterized by a fast inner spine surrounded by a slower layer. This scenario has been widely discussed in the framework of the high-energy emission models for BL Lac objects and radio galaxies. One of the relevant consequences of a velocity structure is the enhancement of the inverse Compton emission caused by the radiative coupling of the two zones. We show that a similar boosting could occurmore » for the neutrino output of the spine through the photo-meson reaction of high-energy protons scattering off the amplified soft target photon field of the layer. Assuming the local density and the cosmological evolution of γ-ray BL Lac object derived from Fermi Large Area Telescope data, we calculate the expected diffuse neutrino intensity, which can match the IceCube data for a reasonable choice of parameters.« less

Assessment of cross-sectional thickness and activity of masseter, anterior temporalis and orbicularis oris muscles in oral submucous fibrosis patients and healthy controls: an ultrasonography and electromyography study.

PubMed

Kant, P; Bhowate, R R; Sharda, N

2014-01-01

Oral submucous fibrosis (OSMF) is an insidious chronic disease that is associated with significant functional morbidity and an increased risk for malignancy. It initially affects the lamina propria of the oral mucosa, and, as the disease progresses, it involves the submucosa and deeper tissue, including muscles of the oral cavity, resulting in loss of fibroelasticity. OSMF is a pre-malignant condition mainly caused by areca nut chewing. The aim of this study was to find out the involvement of muscles of mastication and facial expression in patients with OSMF by assessing the cross-sectional thickness and activity of the masseter, anterior temporalis and orbicularis oris muscles by ultrasonography and electromyography and comparing with healthy controls and also to find out any correlation between the ultrasonographic cross-sectional thicknesses of the masseter, anterior temporalis and orbicularis oris muscles with electromyographic activity. 40 patients with OSMF were included in the study group, and the patients were divided into four groups on the basis of interincisal mouth opening, i.e. Group I (mouth opening >35 mm), Group II (mouth opening between 30 and 35 mm), Group III (mouth opening between 20 and 30 mm) and Group IV (mouth opening <20 mm). Ultrasonographic cross-sectional thickness and electromyographic activity (amplitude and duration) of the masseter, anterior temporalis and orbicualris oris muscles were recorded in patients with OSMF and 20 controls. Intergroup comparison of ultrasonographic cross-sectional thickness and activity (amplitude and duration) was done, and Pearson's correlation coefficient was applied to find out any relation between ultrasonographic and electromyographic findings. Thickness and activity of the masseter muscle was significantly reduced in Group IV (mouth opening <20 mm) when compared with the control group. The anterior temporalis and orbicularis oris muscles remained unaffected. A positive correlation was

The Subaru/XMM-Newton Deep Survey (SXDS). V. Optically Faint Variable Object Survey

NASA Astrophysics Data System (ADS)

Morokuma, Tomoki; Doi, Mamoru; Yasuda, Naoki; Akiyama, Masayuki; Sekiguchi, Kazuhiro; Furusawa, Hisanori; Ueda, Yoshihiro; Totani, Tomonori; Oda, Takeshi; Nagao, Tohru; Kashikawa, Nobunari; Murayama, Takashi; Ouchi, Masami; Watson, Mike G.; Richmond, Michael W.; Lidman, Christopher; Perlmutter, Saul; Spadafora, Anthony L.; Aldering, Greg; Wang, Lifan; Hook, Isobel M.; Knop, Rob A.

2008-03-01

We present our survey for optically faint variable objects using multiepoch (8-10 epochs over 2-4 years) i'-band imaging data obtained with Subaru Suprime-Cam over 0.918 deg2 in the Subaru/XMM-Newton Deep Field (SXDF). We found 1040 optically variable objects by image subtraction for all the combinations of images at different epochs. This is the first statistical sample of variable objects at depths achieved with 8-10 m class telescopes or the Hubble Space Telescope. The detection limit for variable components is i'vari ~ 25.5 mag. These variable objects were classified into variable stars, supernovae (SNe), and active galactic nuclei (AGNs), based on the optical morphologies, magnitudes, colors, and optical-mid-infrared colors of the host objects, spatial offsets of variable components from the host objects, and light curves. Detection completeness was examined by simulating light curves for periodic and irregular variability. We detected optical variability for 36% +/- 2% (51% +/- 3% for a bright sample with i' < 24.4 mag) of X-ray sources in the field. Number densities of variable objects as functions of time intervals Δ t and variable component magnitudes i'vari are obtained. Number densities of variable stars, SNe, and AGNs are 120, 489, and 579 objects deg-2, respectively. Bimodal distributions of variable stars in the color-magnitude diagrams indicate that the variable star sample consists of bright (V ~ 22 mag) blue variable stars of the halo population and faint (V ~ 23.5 mag) red variable stars of the disk population. There are a few candidates of RR Lyrae providing a possible number density of ~10-2 kpc-3 at a distance of >150 kpc from the Galactic center. Based in part on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. Based on observations (program GN-2002B-Q-30) obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a

Constraining the red shifts of TeV BL Lac objects

NASA Astrophysics Data System (ADS)

Qin, Longhua; Wang, Jiancheng; Yan, Dahai; Yang, Chuyuan; Yuan, Zunli; Zhou, Ming

2018-01-01

We present a model-dependent method to estimate the red shifts of three TeV BL Lac objects (BL Lacs) through fitting their (quasi-)simultaneous multi-waveband spectral energy distributions (SEDs) with a one-zone leptonic synchrotron self-Compton model. Considering the impact of electron energy distributions (EEDs) on the results, we use three types of EEDs to fit the SEDs: a power-law EED with exponential cut-off (PLC), a log-parabola (PLLP) EED and the broken power-law (BPL) EED. We also use a parameter α to describe the uncertainties of the extragalactic background light models, as in Abdo et al. We then use a Markov chain Monte Carlo method to explore the multi-dimensional parameter space and obtain the uncertainties of the model parameters based on the observational data. We apply our method to obtain the red shifts of three TeV BL Lac objects in the marginalized 68 per cent confidence, and find that the PLC EED does not fit the SEDs. For 3C66A, the red shift is 0.14-0.31 and 0.16-0.32 in the BPL and PLLP EEDs. For PKS1424+240, the red shift is 0.55-0.68 and 0.55-0.67 in the BPL and PLLP EEDs. For PG1553+113, the red shift is 0.22-0.48 and 0.22-0.39 in the BPL and PLLP EEDs. We also estimate the red shift of PKS1424+240 in the high stage to be 0.46-0.67 in the PLLP EED, roughly consistent with that in the low stage.

A qualitative analysis of Māori and Pacific smokers' views on informed choice and smoking.

PubMed

Gifford, Heather; Tautolo, El-Shadan; Erick, Stephanie; Hoek, Janet; Gray, Rebecca; Edwards, Richard

2016-05-17

Tobacco companies frame smoking as an informed choice, a strategy that holds individuals responsible for harms they incur. Few studies have tested this argument, and even fewer have examined how informed indigenous smokers or those from minority ethnicities are when they start smoking. We explored how young adult Māori and Pacific smokers interpreted 'informed choice' in relation to smoking. Using recruitment via advertising, existing networks and word of mouth, we recruited and undertook qualitative in-depth interviews with 20 Māori and Pacific young adults aged 18-26 years who smoked. Data were analysed using an informed-choice framework developed by Chapman and Liberman. We used a thematic analysis approach to identify themes that extended this framework. Few participants considered themselves well informed and none met more than the framework's initial two criteria. Most reflected on their unthinking uptake and subsequent addiction, and identified environmental factors that had facilitated uptake. Nonetheless, despite this context, most agreed that they had made an informed choice to smoke. The discrepancy between participants' reported knowledge and understanding of smoking's risks, and their assessment of smoking as an informed choice, reflects their view of smoking as a symbol of adulthood. Policies that make tobacco more difficult to use in social settings could help change social norms around smoking and the ease with which initiation and addiction currently occur. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Otariodibacter oris gen. nov., sp. nov., a member of the family Pasteurellaceae isolated from the oral cavity of pinnipeds.

PubMed

Hansen, Mie Johanne; Bertelsen, Mads Frost; Christensen, Henrik; Bojesen, Anders Miki; Bisgaard, Magne

2012-11-01

A total of 27 bacterial isolates from California sea lions and a walrus tentatively classified within the family Pasteurellaceae was further characterized by genotypic and phenotypic tests. Phylogenetic analysis of partial 16S rRNA and rpoB gene sequences showed that the isolates investigated formed a monophyletic group, tentatively designated Bisgaard taxon 57. According to 16S rRNA gene sequences, the most closely related species with a validly published name was Bisgaardia hudsonensis and the most closely related species based on rpoB sequence comparison was Pasteurella multocida subsp. multocida; highest similarities between the isolates and the type strains of B. hudsonensis and P. multocida subsp. multocida were 95.0 and 88.2%. respectively. All isolates of Bisgaard taxon 57 exhibit the phenotypic characters of the family Pasteurellaceae. Members of Bisgaard taxon 57 can be separated from existing genera of the Pasteurellaceae by the following tests: positive reactions for catalase, oxidase, Voges-Proskauer and indole; no X- or V-factor dependency; and acid production from L-arabinose (slow), L-fucose, maltose and trehalose, but not from dulcitol, D-mannitol, D-mannose or sucrose. The main fatty acids of Bisgaard taxon 57 (CCUG 59994(T)) are C(14:0), C(16:0), C(16:1)ω7c and the summed feature C(14:0) 3-OH/iso-C(16:1) I. This fatty acid profile is characteristic of members of the Pasteurellaceae. The quinone profile of Bisgaard taxon 57 (DSM 23800(T)) was similar to that of other genera in the Pasteurellaceae. The DNA G+C content of strain Baika1(T) is 36.2 mol%, which is at the lower end of the range for members of the family Pasteurellaceae. On the basis of both phylogenetic and phenotypic evidence, it is proposed that members of Bisgaard taxon 57 should be classified as representatives of a novel species in a new genus, Otariodibacter oris gen. nov., sp. nov. The type strain of Otariodibacter oris is Baika1(T) (=CCUG 59994(T)=DSM 23800(T)), which was

Cost and Affordability of Diets Modelled on Current Eating Patterns and on Dietary Guidelines, for New Zealand Total Population, Māori and Pacific Households.

PubMed

Mackay, Sally; Buch, Tina; Vandevijvere, Stefanie; Goodwin, Rawinia; Korohina, Erina; Funaki-Tahifote, Mafi; Lee, Amanda; Swinburn, Boyd

2018-06-13

The affordability of diets modelled on the current (less healthy) diet compared to a healthy diet based on Dietary Guidelines was calculated for population groups in New Zealand. Diets using common foods were developed for a household of four for the total population, Māori and Pacific groups. Māori and Pacific nutrition expert panels ensured the diets were appropriate. Each current (less healthy) diet was based on eating patterns identified from national nutrition surveys. Food prices were collected from retail outlets. Only the current diets contained alcohol, takeaways and discretionary foods. The modelled healthy diet was cheaper than the current diet for the total population (3.5% difference) and Pacific households (4.5% difference) and similar in cost for Māori households (0.57% difference). When the diets were equivalent in energy, the healthy diet was more expensive than the current diet for all population groups (by 8.5% to 15.6%). For households on the minimum wage, the diets required 27% to 34% of household income, and if receiving income support, required 41⁻52% of household income. Expert panels were invaluable in guiding the process for specific populations. Both the modelled healthy and current diets are unaffordable for some households as a considerable portion of income was required to purchase either diet. Policies are required to improve food security by lowering the cost of healthy food or improving household income.

Lethality of sortase depletion in Actinomyces oris caused by excessive membrane accumulation of a surface glycoprotein.

PubMed

Wu, Chenggang; Huang, I-Hsiu; Chang, Chungyu; Reardon-Robinson, Melissa Elizabeth; Das, Asis; Ton-That, Hung

2014-12-01

Sortase, a cysteine-transpeptidase conserved in Gram-positive bacteria, anchors on the cell wall many surface proteins that facilitate bacterial pathogenesis and fitness. Genetic disruption of the housekeeping sortase in several Gram-positive pathogens reported thus far attenuates virulence, but not bacterial growth. Paradoxically, we discovered that depletion of the housekeeping sortase SrtA was lethal for Actinomyces oris; yet, all of its predicted cell wall-anchored protein substrates (AcaA-N) were individually dispensable for cell viability. Using Tn5-transposon mutagenesis to identify factors that upend lethality of srtA deletion, we uncovered a set of genetic suppressors harbouring transposon insertions within genes of a locus encoding AcaC and a LytR-CpsA-Psr (LCP)-like protein. AcaC was shown to be highly glycosylated and dependent on LCP for its glycosylation. Upon SrtA depletion, the glycosylated form of AcaC, hereby renamed GspA, was accumulated in the membrane. Overexpression of GspA in a mutant lacking gspA and srtA was lethal; conversely, cells overexpressing a GspA mutant missing a membrane-localization domain were viable. The results reveal a unique glycosylation pathway in A. oris that is coupled to cell wall anchoring catalysed by sortase SrtA. Significantly, this novel phenomenon of glyco-stress provides convenient cell-based assays for developing a new class of inhibitors against Gram-positive pathogens. © 2014 John Wiley & Sons Ltd.

Introduction à une théorie des systèmes composites : exemples simples de matériaux lamellaires

NASA Astrophysics Data System (ADS)

Akjouj, A.; Sylla, B.; Dobrzynski, L.

This review paper is mostly an introduction to the linear response theory for composite systems. The composite materials are defined here as being formed by different homogeneous parts connected together by interfaces. This type of material can be constructed with the help of homogeneous "bricks" cuted out from infinite materials. This cutting procedures are realized with the help of cleavage operators. The "bricks" are then put together by a coupling operator. This construction manner enables to obtain for any composite system a general equation relating the composite response function (called also Green's function) to the elements of the infinite material response functions and to the cleavage and coupling operators. A general and unified formulation valid as well in matrix algebra as in the algebra of differential equations results from this approach. Any general theory is abstract ; simple examples help very much to understand it. The principal aim of this review paper is the introduction of a general theory for composite systems through simple and analytical examples from the fields of phonons, magnons and electrons in the lamellar composite materials. In order to achieve this goal, the algebra of the examples is as explicit as possible. The references of what was already realized in theory of composite response are discussed also. A prospective and non exhaustive study of all the fields where such a theory can prove to be helpful is given also in this review paper. Cet article de revue est essentiellement une introduction à la théorie de la réponse linéaire dans les systèmes composites. Les matériaux composites sont définis ici comme étant formés de parties homogènes différentes reliées par des interfaces. Ce type de matériaux peut être construit à partir de "briques" homogènes découpées dans des matériaux infinis. Ces opérations de découpage sont effectuées par l'intermédiaire d'opérateurs de clivage. Les "briques" sont ensuite

Crisis engagement in mental health: a New Zealand Māori contribution.

PubMed

Drury, Nick; Munro, Te Ata

2008-10-01

The active engagement of clients in mental health services offers far greater chances of successful outcomes. When clients do not actively engage in treatment, their risk of becoming part of the population of 'high users' is greater. The 'high users' consume a disproportionate share of health resources, which may prevent other potential clients from accessing services. Engagement can be particularly challenging in crisis situations, which is how many clients attracting psychotic diagnoses first enter the service. New Zealand Māori bring a transcendent quality to the idea of 'respect for Other', which would make it sacrilegious to overpower Other in most situations. This paper reviews a growing body of literature indicating how we might integrate an enhanced respect or reverence of Other into clinical practice. This includes the idea of engaging more frequently with the social network when building rapport with an individual is particularly challenging. There is some evidence that services adopting this kind of approach are more economical.

Electromyographic analysis of superior orbicularis oris muscle function in children surgically treated for unilateral complete cleft lip and palate.

PubMed

Szyszka-Sommerfeld, Liliana; Woźniak, Krzysztof; Matthews-Brzozowska, Teresa; Kawala, Beata; Mikulewicz, Marcin

2017-09-01

The aim of this study was to assess the electrical activity of the superior orbicularis oris muscle in children surgically treated for unilateral complete cleft lip and palate (UCCLP). The sample comprised 45 patients 6.38-12.68 years of age with UCCLP and 40 subjects 6.61-11.71 years of age with no clefts. Electromyographical (EMG) recordings were taken with a DAB-Bluetooth Instrument (Zebris Medical GmbH, Germany) in the rest position and during saliva swallowing, lip protrusion and reciprocal compression of the lips, as well as while producing the phonemes /p/, /b/, and /m/ combined with the vowel /a/. The electrical activity of the upper lip during saliva swallowing and lip compression was significantly greater in the cleft group. Similar resting level activity was observed in both groups. During the production of the /p/, /b/, and /m/ phonemes combined with the vowel /a/ the results showed no significant differences in the EMG activity between children with UCCLP and noncleft subjects. Patients with UCCLP have abnormal upper lip function characterized by increased activity of the superior orbicularis oris muscle during saliva swallowing and lip compression, and this may affect facial morphology. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

A solution for the binary system V1373 Orionis

NASA Astrophysics Data System (ADS)

Hauck, Norbert

2016-02-01

Binary system V1373 Ori (HD 36107) has been investigated in the photometric passbands VIc and by spectroscopy (radial velocities). Modelling of the data delivered a single and consistent solution for a detached configuration consisting of a large K-type giant primary component having a radius of 39.40 ± 0.43 Rsun and a mass of 1.132 ± 0.043 Msun, and an invisible dwarf secondary component having a mass of 0.661 ± 0.025 Msun. The red giant fits into a stellar model for a moderately sub-solar metallicity of Z = 0.008. [English and German online-version available under www.bav-astro.eu/rb/rb2016-2/4.html].

Electron Transport Chain Is Biochemically Linked to Pilus Assembly Required for Polymicrobial Interactions and Biofilm Formation in the Gram-Positive Actinobacterium Actinomyces oris.

PubMed

Sanchez, Belkys C; Chang, Chungyu; Wu, Chenggang; Tran, Bryan; Ton-That, Hung

2017-06-20

The Gram-positive actinobacteria Actinomyces spp. are key colonizers in the development of oral biofilms due to the inherent ability of Actinomyces to adhere to receptor polysaccharides on the surface of oral streptococci and host cells. This receptor-dependent bacterial interaction, or coaggregation, requires a unique sortase-catalyzed pilus consisting of the pilus shaft FimA and the coaggregation factor CafA forming the pilus tip. While the essential role of the sortase machine SrtC2 in pilus assembly, biofilm formation, and coaggregation has been established, little is known about trans -acting factors contributing to these processes. We report here a large-scale Tn 5 transposon screen for mutants defective in Actinomyces oris coaggregation with Streptococcus oralis We obtained 33 independent clones, 13 of which completely failed to aggregate with S. oralis , and the remainder of which exhibited a range of phenotypes from severely to weakly defective coaggregation. The former had Tn 5 insertions in fimA , cafA , or srtC2 , as expected; the latter were mapped to genes coding for uncharacterized proteins and various nuo genes encoding the NADH dehydrogenase subunits. Electron microscopy and biochemical analyses of mutants with nonpolar deletions of nuo genes and ubiE , a menaquinone C-methyltransferase-encoding gene downstream of the nuo locus, confirmed the pilus and coaggregation defects. Both nuoA and ubiE mutants were defective in oxidation of MdbA, the major oxidoreductase required for oxidative folding of pilus proteins. Furthermore, supplementation of the ubiE mutant with exogenous menaquinone-4 rescued the cell growth and pilus defects. Altogether, we propose that the A. oris electron transport chain is biochemically linked to pilus assembly via oxidative protein folding. IMPORTANCE The Gram-positive actinobacterium A. oris expresses adhesive pili, or fimbriae, that are essential to biofilm formation and Actinomyces interactions with other bacteria

Maternal and neonatal health impact of obstetrical risk insurance scheme in Mauritania: a quasi experimental before-and-after study.

PubMed

Philibert, Aline; Ravit, Marion; Ridde, Valéry; Dossa, Inès; Bonnet, Emmanuel; Bedecarrats, Florent; Dumont, Alexandre

2017-04-01

A variety of health financing schemes shaped on pre-payment scheme have been implemented across Sub-Saharan Africa (SSA) to address the Millennium Development Goals (MDGs). In Mauritania, the Obstetric Risk Insurance package (ORI) focusing on maternal and perinatal health has been progressively implemented at the health district level since 2002. Here, our main objective was to assess the effectiveness of the ORI in increasing facility-based delivery rates, as well as increases in family planning, antenatal and postnatal care, caesarean delivery and neonatal health, from demographic and health survey data between 2002 and 2011. We also examined whether the effects of the ORI varied between strata of the population. The study was based on a quasi-experimental before-and-after design to assess the causal link between availability of ORI and increase in use of maternal health services and neonatal mortality. In combination with geographical information system, difference-in-differences and odd ratio approaches were used to address our objectives. Indicators of access to care for pregnant women and neonatal health and improved in both non-intervention and intervention groups during the study period. There was no global effect of the availability of ORI on facility-based delivery rates, nor on the use of antenatal and postnatal care services, except for qualified antenatal services. However, delivery rates in local health centres with ORI increased more rapidly than in those with no ORI, the contrary was shown for hospitals. Caesarean delivery and family planning decreased with ORI. Although late neonatal mortality rates remained low in the country, a significant decrease was seen in districts without ORI. Except for some strata of the population, ORI has not really met its objective of attracting more pregnant women towards facility-based health care. © The Author 2016. Published by Oxford University Press in association with The London School of Hygiene and Tropical

A New Spectroscopic and Interferometric Study of the Young Stellar Object V645 Cyg

NASA Technical Reports Server (NTRS)

Miroshinichenko, A. S.; Hofmann, K.-H.; Schertl, D.; Weigelt, G.; Kraus, S.; Manset, N.; Balega, Y. Y.; Klochkova, V. G.; Rudy, R. J.; Lynch, D. K.;

Analysis of cis and trans Requirements for DNA Replication at the Right-End Hairpin of the Human Bocavirus 1 Genome

PubMed Central

Shen, Weiran; Deng, Xuefeng; Zou, Wei; Engelhardt, John F.; Yan, Ziying

2016-01-01

ABSTRACT Parvoviruses are single-stranded DNA viruses that use the palindromic structures at the ends of the viral genome for their replication. The mechanism of parvovirus replication has been studied mostly in the dependoparvovirus adeno-associated virus 2 (AAV2) and the protoparvovirus minute virus of mice (MVM). Here, we used human bocavirus 1 (HBoV1) to understand the replication mechanism of bocaparvovirus. HBoV1 is pathogenic to humans, causing acute respiratory tract infections, especially in young children under 2 years old. By using the duplex replicative form of the HBoV1 genome in human embryonic kidney 293 (HEK293) cells, we identified the HBoV1 minimal replication origin at the right-end hairpin (OriR). Mutagenesis analyses confirmed the putative NS1 binding and nicking sites within the OriR. Of note, unlike the large nonstructural protein (Rep78/68 or NS1) of other parvoviruses, HBoV1 NS1 did not specifically bind OriR in vitro, indicating that other viral and cellular components or the oligomerization of NS1 is required for NS1 binding to the OriR. In vivo studies demonstrated that residues responsible for NS1 binding and nicking are within the origin-binding domain. Further analysis identified that the small nonstructural protein NP1 is required for HBoV1 DNA replication at OriR. NP1 and other viral nonstructural proteins (NS1 to NS4) colocalized within the viral DNA replication centers in both OriR-transfected cells and virus-infected cells, highlighting a direct involvement of NP1 in viral DNA replication at OriR. Overall, our study revealed the characteristics of HBoV1 DNA replication at OriR, suggesting novel characteristics of autonomous parvovirus DNA replication. IMPORTANCE Human bocavirus 1 (HBoV1) causes acute respiratory tract infections in young children. The duplex HBoV1 genome replicates in HEK293 cells and produces progeny virions that are infectious in well-differentiated airway epithelial cells. A recombinant AAV2 vector pseudotyped

The Actinomyces oris Type 2 Fimbrial Shaft FimA Mediates Coaggregation with Oral Streptococci, Adherence to RBC and Biofilm Development

PubMed Central

Mishra, Arunima; Wu, Chenggang; Yang, Jinghua; Cisar, John O.; Das, Asis; Ton-That, Hung

2010-01-01

Interbacterial interactions between oral streptococci and actinomyces and their adherence to tooth surface and the associated host cells are key early events that promote development of the complex oral biofilm referred to as dental plaque. These interactions depend largely on a lectin-like activity associated with the Actinomyces oris type 2 fimbria, a surface structure assembled by sortase (SrtC2)-dependent polymerization of the shaft and tip fimbrillins, FimA and FimB, respectively. To dissect the function of specific fimbrillins in various adherence processes, we have developed a convenient new technology for generating unmarked deletion mutants of A. oris. Here, we show that the fimB mutant, which produced type 2 fimbriae composed only of FimA, like the wild type coaggregated strongly with receptor-bearing streptococci, agglutinated with sialidase-treated RBC, and formed monospecies biofilm. In contrast, the fimA and srtC2 mutants lacked type 2 fimbriae and were non-adherent in each of these assays. Plasmidbased expression of the deleted gene in respective mutants restored adherence to wild-type levels. These findings uncover the importance of the lectin-like activity of the polymeric FimA shaft rather than the tip. The multivalent adhesive function of FimA makes it an ideal molecule for exploring novel intervention strategies to control plaque biofilm formation. PMID:20545853

MERS-CoV infection: Mind the public knowledge gap.

PubMed

Bawazir, Amen; Al-Mazroo, Eman; Jradi, Hoda; Ahmed, Anwar; Badri, Motasim

In August 2015, the Corona outbreak caused by Middle East respiratory syndrome coronavirus (MERS-CoV) was the 9th episode since June 2012 in Saudi Arabia. Little is known about the public awareness toward the nature or prevention of the disease. The aim of this work was to assess the knowledge of the adult population in Riyadh toward the MERS-CoV. In this cross-sectional survey, a self-administrated questionnaire was distributed to randomly selected participants visiting malls in Riyadh. The questionnaire contained measurable epidemiological and clinical MERS-CoV knowledge level variables and relevant source of information. The study included 676 participants. Mean age was 32.5 (±SD 8.6) years and 353 (47.8%) were males. Almost all participants heard about the corona disease and causative agent. The study showed a fair overall knowledge (66.0%), less knowledge on epidemiological features of the disease (58.3%), and good knowledge (90.7%) on the clinical manifestation of the MERS-CoV. Internet was the major (89.0%) source of disease information, and other sources including health care providers, SMS, television, magazines and books were low rated (all <25%). In a multivariate logistic regression analysis age ≤30 years (Odds Ratio (OR)=1.647, 95%CI 1.048-2.584, P=0.030), male gender (OR=1.536, 95%CI 1.105-2.134, P=0.01), and no tertiary education (OR=1.957, 95%CI 1.264-3.030, P=0.003) were independent significant predictors of poor epidemiological knowledge. This study concludes that there was inadequate epidemiological knowledge received by the public and the reliance mostly on the clinical manifestations to recognizing the MERS-CoV disease. Comprehensive public health education programs is important to increase awareness of simple epidemiological determinants of the disease is warranted. Copyright © 2017. Published by Elsevier Ltd.

On the Redshift of TeV BL Lac Objects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paiano, Simona; Falomo, Renato; Landoni, Marco

2017-03-10

We report results of a spectroscopic campaign carried out at the 10 m Gran Telescopio Canarias for a sample of 22 BL Lac objects detected (or candidates) at TeV energies, aiming to determine or constrain their redshift. This is of fundamental importance for the interpretation of their emission models and for population studies and is also mandatory for studying the interaction of high-energy photons with the extragalactic background light using TeV sources. Optical spectra with high signal-to-noise ratios in the range 4250–10000 Å were obtained to search for faint emission or absorption lines from both the host galaxy and themore » nucleus. We determine a new redshift for PKS 1424+240 ( z = 0.604) and a tentative one for 1ES 0033+595 ( z = 0.467). We are able to set new spectroscopic redshift lower limits for three other sources on the basis of Mg ii and Ca ii intervening absorption features: BZB J1243+3627 ( z > 0.483), BZB J1540+8155 ( z > 0.672), and BZB 0J2323+4210 ( z > 0.267). We confirm previous redshift estimates for four blazars: S3 0218+357 ( z = 0.944), 1ES 1215+303 ( z = 0.129), W Comae ( z = 0.102), and MS 1221.8+2452 ( z = 0.218). For the remaining targets, in seven cases (S2 0109+22, 3C 66A, VER J0521+211, S4 0954+65, BZB J1120+4214, S3 1227+25, BZB J2323+4210), we do not validate the proposed redshift. Finally, for all sources of still-unknown redshift, we set a lower limit based on the minimum equivalent width of absorption features expected from the host galaxy.« less

Nanostructured lipid carriers used for oral delivery of oridonin: an effect of ligand modification on absorption.

PubMed

Zhou, Xiaotong; Zhang, Xingwang; Ye, Yanghuan; Zhang, Tianpeng; Wang, Huan; Ma, Zhiguo; Wu, Baojian

2015-02-20

Oridonin (Ori) is a natural compound with notable anti-inflammation and anti-cancer activities. However, therapeutic use of this compound is limited by its poor solubility and low bioavailability. Here a novel biotin-modified nanostructured lipid carrier (NLC) was developed to enhance the bioavailability of Ori. The effect of ligand (biotin) modification on oral absorption of Ori encapsulated in NLCs was also explored. Ori-loaded NLCs (Ori-NLCs) were prepared by the melt dispersion-high pressure homogenization method. Biotin modification of Ori-NLCs was achieved by EDC and NHS in aqueous phase. The obtained biotin-decorated Ori-NLCs (Bio-Ori-NLCs) were 144.9nm in size with an entrapment efficiency of 49.54% and a drug load of 4.81%. Oral bioavailability was enhanced by use of Bio-Ori-NLCs with a relative bioavailability of 171.01%, while the value of non-modified Ori-NLCs was improved to 143.48%. Intestinal perfusion showed that Ori solution unexpectedly exhibited a moderate permeability, indicating that permeability was not a limiting factor of Ori absorption. Ori could be rapidly metabolized that was the main cause of low bioavailability. However, there was a difference in the enhancement of bioavailability between Bio-Ori-NLCs and conventional NLCs. Although severe lipolyses happened both on Bio-Ori-NLCs and non-modified NLCs, the performance of Bio-Ori-NLCs in the bioavailability improvement was more significant. Overall, Bio-Ori-NLCs can further promote the oral absorption of Ori by a ligand-mediated active transport. It may be a promising carrier for the oral delivery of Ori. Copyright © 2014 Elsevier B.V. All rights reserved.

Direct Interferometric Imaging with IOTA Interferometer: Morphology of the Water Shell around U Ori

NASA Astrophysics Data System (ADS)

Pluzhnik, Eugene; Ragland, S.; Le Coroller, H.; Cotton, W.; Danchi, W.; Traub, W.; Willson, L.

2007-12-01

Optical interferometric observations of Mira stars with adequate resolution using the 3-telescope Infrared Optical Telescope Array (IOTA) interferometer have shown detectable asymmetry in several Mira stars. Several mechanisms have been proposed to explain the observed asymmetry. In this paper, we present subsequent IOTA observations of a Mira star, namely, U Ori taken at 1.51, 1.64 and 1.78 μm in 2005. The reconstructed images based on a model independent algorithm are also presented. These images show asymmetric structures of the water shell that is similar to the structure of 22 GHz masers obtained by Vlemmings et al. in 2003. We explore the possibility of the detection of molecular shell rotation with a period of about 30 years by comparing our results with radio observations and discuss a possible geometric structure of the shell.

A new spectroscopic and interferometric study of the young stellar object V645 Cygni

NASA Astrophysics Data System (ADS)

Miroshnichenko, A. S.; Hofmann, K.-H.; Schertl, D.; Weigelt, G.; Kraus, S.; Manset, N.; Albert, L.; Balega, Y. Y.; Klochkova, V. G.; Rudy, R. J.; Lynch, D. K.; Mazuk, S.; Venturini, C. C.; Russell, R. W.; Grankin, K. N.; Puetter, R. C.; Perry, R. B.

2009-04-01

Aims: We present the results of high-resolution optical spectroscopy, low-resolution near-IR spectroscopy and near-infrared speckle interferometry of the massive young stellar object candidate V645 Cyg, acquired to refine its fundamental parameters and the properties of its circumstellar envelope. Methods: Speckle interferometry in the H- and K-bands and an optical spectrum in the range 5200-6680 Å with a spectral resolving power of R = 60 000 were obtained at the 6 m telescope of the Russian Academy of Sciences. Another optical spectrum in the range 4300-10 500 Å with R = 79 000 was obtained at the 3.6 m CFHT. Low-resolution spectra in the ranges 0.46-1.4 μm and 1.4-2.5 μm with R ~ 800 and ~700, respectively, were obtained at the 3 m Shane telescope of the Lick Observatory. Results: Using a novel kinematical method based on the non-linear modeling of the neutral hydrogen density profile in the direction toward the object, we propose a distance of D = 4.2 ± 0.2 kpc. We also suggest a revised estimate of the star's effective temperature, T_eff ~ 25 000 K. We resolved the object in both H- and K-bands. Using a two-component ring fit, we derived a compact component size of 14 mas and 12 mas in the H- and K-band, respectively, which correspond to 29 and 26 AU at the revised distance. Analysis of our own and previously published data indicates a ~2 mag decrease in the near-infrared brightness of V645 Cyg at the beginning of the 1980's. At the same time, the cometary nebular condensation N1 appears to fade in this wavelength range with respect to the N0 object, representing the star with a nearly pole-on optically-thick disk and an optically-thin envelope. Conclusions: We conclude that V645 Cyg is a young, massive, main-sequence star, which recently emerged from its cocoon and has already experienced its protostellar accretion stage. The presence of accretion is not necessary to account for the high observed luminosity of (2-6) × 104 M⊙ yr-1. The receding part of

Analysis of cis and trans Requirements for DNA Replication at the Right-End Hairpin of the Human Bocavirus 1 Genome.

PubMed

Shen, Weiran; Deng, Xuefeng; Zou, Wei; Engelhardt, John F; Yan, Ziying; Qiu, Jianming

2016-09-01

Parvoviruses are single-stranded DNA viruses that use the palindromic structures at the ends of the viral genome for their replication. The mechanism of parvovirus replication has been studied mostly in the dependoparvovirus adeno-associated virus 2 (AAV2) and the protoparvovirus minute virus of mice (MVM). Here, we used human bocavirus 1 (HBoV1) to understand the replication mechanism of bocaparvovirus. HBoV1 is pathogenic to humans, causing acute respiratory tract infections, especially in young children under 2 years old. By using the duplex replicative form of the HBoV1 genome in human embryonic kidney 293 (HEK293) cells, we identified the HBoV1 minimal replication origin at the right-end hairpin (OriR). Mutagenesis analyses confirmed the putative NS1 binding and nicking sites within the OriR. Of note, unlike the large nonstructural protein (Rep78/68 or NS1) of other parvoviruses, HBoV1 NS1 did not specifically bind OriR in vitro, indicating that other viral and cellular components or the oligomerization of NS1 is required for NS1 binding to the OriR. In vivo studies demonstrated that residues responsible for NS1 binding and nicking are within the origin-binding domain. Further analysis identified that the small nonstructural protein NP1 is required for HBoV1 DNA replication at OriR. NP1 and other viral nonstructural proteins (NS1 to NS4) colocalized within the viral DNA replication centers in both OriR-transfected cells and virus-infected cells, highlighting a direct involvement of NP1 in viral DNA replication at OriR. Overall, our study revealed the characteristics of HBoV1 DNA replication at OriR, suggesting novel characteristics of autonomous parvovirus DNA replication. Human bocavirus 1 (HBoV1) causes acute respiratory tract infections in young children. The duplex HBoV1 genome replicates in HEK293 cells and produces progeny virions that are infectious in well-differentiated airway epithelial cells. A recombinant AAV2 vector pseudotyped with an HBoV1

Sugar, dental caries and the incidence of acute rheumatic fever: a cohort study of Māori and Pacific children.

PubMed

Thornley, Simon; Marshall, Roger J; Bach, Katie; Koopu, Pauline; Reynolds, Gary; Sundborn, Gerhard; Ei, Win Le Shwe Sin

2017-04-01

To determine whether dental caries, as an indicator of cumulative exposure to sugar, is associated with the incidence of acute rheumatic fever and chronic rheumatic heart disease, in Māori and Pacific children aged 5 and 6 years at their first dental visit. A cohort study was undertaken which linked school dental service records of caries with national hospital discharge and mortality records. Cox models were used to investigate the strength of the association between dental caries and rheumatic fever incidence. A total of 20 333 children who were free of rheumatic heart disease at enrolment were available for analysis. During a mean follow-up time of 5 years, 96 children developed acute rheumatic fever or chronic rheumatic heart disease. After adjustment for potential confounders, children with five or more primary teeth affected by caries were 57% (95% CI: 20% to 106%) more likely to develop disease during follow-up, compared to children whose primary teeth were caries free. The population attributable to the risk for caries in this cohort was 22%. Dental caries is positively associated with the incidence of acute rheumatic fever and chronic rheumatic heart disease in Māori and Pacific children. Sugar intake, an important risk factor for dental caries, is also likely to influence the aetiology of rheumatic fever. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Arrangement of the orbicularis oris muscle in different types of cleft lips.

PubMed

Wijayaweera, C J; Amaratunga, N A; Angunawela, P

2000-05-01

A thorough knowledge of the anatomy of the labial region, especially the arrangement of the muscle fibers, is essential for the success of primary repair of the cleft lip. Pared lateral and medial edges from 20 unilateral incomplete cleft lips and 25 unilateral complete cleft lips were obtained during primary surgery. Three specimens of normal lips were taken from unclaimed infant cadavers as the controls. They were prepared for routine histological studies and were examined to study the direction of muscle fibers. Intrinsic and extrinsic bundles were identified in both lateral and medial sides of specimens of both cleft types. The intrinsic bundle was not displaced but was interrupted by the cleft. The extrinsic bundle in the lateral side of both cleft types ran upward along the lateral cleft margin, whereas in the medial side it ran horizontally to terminate close to the medial cleft margin. The extrinsic bundle is the retractor, which is associated with facial expression, whereas the intrinsic bundle is the constrictor of the mouth. Because there are two functional components in the orbicularis oris muscle, identifying and repairing them separately will enable each of them to accomplish their distinctive functions.

Randomly picked cosmid clones overlap the pyrB and oriC gap in the physical map of the E. coli chromosome.

PubMed Central

Knott, V; Rees, D J; Cheng, Z; Brownlee, G G

1988-01-01

Sets of overlapping cosmid clones generated by random sampling and fingerprinting methods complement data at pyrB (96.5') and oriC (84') in the published physical map of E. coli. A new cloning strategy using sheared DNA, and a low copy, inducible cosmid vector were used in order to reduce bias in libraries, in conjunction with micro-methods for preparing cosmid DNA from a large number of clones. Our results are relevant to the design of the best approach to the physical mapping of large genomes. PMID:2834694

75 FR 22400 - Clean Air Act Operating Permit Program; Petition To Object to Title V Permit for Wheelabrator...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

... ENVIROMENTAL PROTECTION AGENCY [FRL-9142-6] Clean Air Act Operating Permit Program; Petition To Object to Title V Permit for Wheelabrator Baltimore, L.P., Baltimore City, MD AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of final action. SUMMARY: Pursuant to section 505(b)(2) of the Clean...

Socioeconomic correlates of quality of life for non-Māori in advanced age: Te Puāwaitanga o Nga Tapuwae Kia ora Tonu. Life and Living in Advanced Age: a Cohort Study in New Zealand (LiLACS NZ).

PubMed

Kerse, Ngaire; Teh, Ruth; Moyes, Simon A; Dyall, Lorna; Wiles, Janine L; Kēpa, Mere; Wham, Carol; Hayman, Karen; Connolly, Martin; Wilkinson, Tim; Wright St Clair, Valerie; Keeling, Sally; Broad, Joanna; Jatrana, Santosh; Lumley, Thomas

2016-09-09

To establish socioeconomic and cultural profiles and correlates of quality of life (QoL) in non-Māori of advanced age. A cross sectional analysis of the baseline data of a cohort study of 516 non-Māori aged 85 years living in the Bay of Plenty and Rotorua areas of New Zealand. Socioeconomic and cultural characteristics were established by face-to-face interviews in 2010. Health-related QoL (HRQoL) was assessed with the SF-12. Of the 516 non-Māori participants enrolled in the study, 89% identified as New Zealand European, 10% other European, 1% were of Pacific, Asian or Middle Eastern ethnicity; 20% were born overseas and half of these identified as 'New Zealand European.' More men were married (59%) and more women lived alone (63%). While 89% owned their own home, 30% received only the New Zealand Superannuation as income and 22% reported that they had 'just enough to get along on'. More than 85% reported that they had sufficient practical and emotional support; 11% and 6% reported unmet need for practical and emotional support respectively. Multivariate analyses showed that those with unmet needs for practical and emotional support had lower mental HR QoL (p<0.005). Reporting that family were important to wellbeing was associated with higher mental HR QoL (p=0.038). Those that did not need practical help (p=0.047) and those that reported feeling comfortable with their money situation (0.0191) had higher physical HRQoL. High functional status was strongly associated with both high mental and high physical HR QoL (p<0.001). Among our sample of non-Māori people of advanced age, those with unmet support needs reported low HRQoL. Functional status was most strongly associated with mental and physical HRQoL.

Detection of the supercycle in V4140 Sagittarii: First eclipsing ER Ursae Majoris-like object

NASA Astrophysics Data System (ADS)

Kato, Taichi; Hambsch, Franz-Josef; Cook, Lewis M.

2018-05-01

We observed the deeply eclipsing SU UMa-type dwarf nova V4140 Sgr and established the very short supercycle of 69.7(3) d. There were several short outbursts between superoutbursts. These values, together with the short orbital period (0.06143 d), were similar to, but not as extreme as, those of ER UMa-type dwarf novae. The object is thus the first, long sought, eclipsing ER UMa-like object. This ER UMa-like nature can naturally explain the high (apparent) quiescent viscosity and unusual temperature profile in quiescence, which were claimed observational features against the thermal-tidal instability model. The apparently unusual outburst behavior can be reasonably explained by a combination of this ER UMa-like nature and the high orbital inclination, and there is no need to introduce mass transfer bursts from its donor star.

Detection of the supercycle in V4140 Sagittarii: First eclipsing ER Ursae Majoris-like object

NASA Astrophysics Data System (ADS)

Kato, Taichi; Hambsch, Franz-Josef; Cook, Lewis M.

2018-06-01

We observed the deeply eclipsing SU UMa-type dwarf nova V4140 Sgr and established the very short supercycle of 69.7(3) d. There were several short outbursts between superoutbursts. These values, together with the short orbital period (0.06143 d), were similar to, but not as extreme as, those of ER UMa-type dwarf novae. The object is thus the first, long sought, eclipsing ER UMa-like object. This ER UMa-like nature can naturally explain the high (apparent) quiescent viscosity and unusual temperature profile in quiescence, which were claimed observational features against the thermal-tidal instability model. The apparently unusual outburst behavior can be reasonably explained by a combination of this ER UMa-like nature and the high orbital inclination, and there is no need to introduce mass transfer bursts from its donor star.

SIMULTANEOUS B'V'R' MONITORING OF BL LACERTAE OBJECT S5 0716+714 AND DETECTION OF INTER-BAND TIME DELAY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu Jianghua; He Xiangtao; Boettcher, Markus

We present the results of our optical monitoring of the BL Lac object S5 0716+714 over seven nights in 2006 December. The monitoring was carried out simultaneously at three optical wavelengths with a novel photometric system. The object did not show large-amplitude internight variations during this period. Intranight variations were observed on four nights and probably on one more. Strong bluer-when-brighter chromatism was detected on both intranight and internight timescales. The intranight variation amplitude decreases in the wavelength sequence of B', R', and V'. Cross-correlation analyses revealed that the variability at the B' and V' bands leads that at themore » R' band by about 30 minutes on one night.« less

Multi-objective optimization of an industrial penicillin V bioreactor train using non-dominated sorting genetic algorithm.

PubMed

Lee, Fook Choon; Rangaiah, Gade Pandu; Ray, Ajay Kumar

2007-10-15

Bulk of the penicillin produced is used as raw material for semi-synthetic penicillin (such as amoxicillin and ampicillin) and semi-synthetic cephalosporins (such as cephalexin and cefadroxil). In the present paper, an industrial penicillin V bioreactor train is optimized for multiple objectives simultaneously. An industrial train, comprising a bank of identical bioreactors, is run semi-continuously in a synchronous fashion. The fermentation taking place in a bioreactor is modeled using a morphologically structured mechanism. For multi-objective optimization for two and three objectives, the elitist non-dominated sorting genetic algorithm (NSGA-II) is chosen. Instead of a single optimum as in the traditional optimization, a wide range of optimal design and operating conditions depicting trade-offs of key performance indicators such as batch cycle time, yield, profit and penicillin concentration, is successfully obtained. The effects of design and operating variables on the optimal solutions are discussed in detail. Copyright 2007 Wiley Periodicals, Inc.

NYPIRG Petition to Object to Tanagraphics, Inc. Title V Permit

EPA Pesticide Factsheets

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NYPIRG Petion to Object ot Kings Plaza Title V Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

NYPIRG Petition to Object to Elmhurst Hospital's Title V Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Sullivan County Landfill, Petition to Object to Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Generation of Wheat Transcription Factor FOX Rice Lines and Systematic Screening for Salt and Osmotic Stress Tolerance.

PubMed

Wu, Jinxia; Zhang, Zhiguo; Zhang, Qian; Liu, Yayun; Zhu, Butuo; Cao, Jian; Li, Zhanpeng; Han, Longzhi; Jia, Jizeng; Zhao, Guangyao; Sun, Xuehui

2015-01-01

Transcription factors (TFs) play important roles in plant growth, development, and responses to environmental stress. In this study, we collected 1,455 full-length (FL) cDNAs of TFs, representing 45 families, from wheat and its relatives Triticum urartu, Aegilops speltoides, Aegilops tauschii, Triticum carthlicum, and Triticum aestivum. More than 15,000 T0 TF FOX (Full-length cDNA Over-eXpressing) rice lines were generated; of these, 10,496 lines set seeds. About 14.88% of the T0 plants showed obvious phenotypic changes. T1 lines (5,232 lines) were screened for salt and osmotic stress tolerance using 150 mM NaCl and 20% (v/v) PEG-4000, respectively. Among them, five lines (591, 746, 1647, 1812, and J4065) showed enhanced salt stress tolerance, five lines (591, 746, 898, 1078, and 1647) showed enhanced osmotic stress tolerance, and three lines (591, 746, and 1647) showed both salt and osmotic stress tolerance. Further analysis of the T-DNA flanking sequences showed that line 746 over-expressed TaEREB1, line 898 over-expressed TabZIPD, and lines 1812 and J4065 over-expressed TaOBF1a and TaOBF1b, respectively. The enhanced salt and osmotic stress tolerance of lines 898 and 1812 was confirmed by retransformation of the respective genes. Our results demonstrate that a heterologous FOX system may be used as an alternative genetic resource for the systematic functional analysis of the wheat genome.

The 'warrior gene' and the Mãori people: the responsibility of the geneticists.

PubMed

Perbal, Laurence

2013-09-01

The 'gene of' is a teleosemantic expression that conveys a simplistic and linear relationship between a gene and a phenotype. Throughout the 20th century, geneticists studied these genes of traits. The studies were often polemical when they concerned human traits: the 'crime gene', 'poverty gene', 'IQ gene', 'gay gene' or 'gene of alcoholism'. Quite recently, a controversy occurred in 2006 in New Zealand that started with the claim that a 'warrior gene' exists in the Mãori community. This claim came from a geneticist working on the MAOA gene. This article is interested in the responsibility of that researcher regarding the origin of the controversy. Several errors were made: overestimation of results, abusive use of the 'gene of' kind of expression, poor communication with the media and a lack of scientific culture. The issues of the debate were not taken into account sufficiently, either from the political, social, ethical or even the genetic points of view. After more than 100 years of debates around 'genes of' all kinds (here, the 'warrior gene'), geneticists may not hide themselves behind the media when a controversy occurs. Responsibilities have to be assumed. © 2012 John Wiley & Sons Ltd.

The Palomar Transient Factory Orion Project: Eclipsing Binaries and Young Stellar Objects

NASA Astrophysics Data System (ADS)

van Eyken, Julian C.; Ciardi, David R.; Rebull, Luisa M.; Stauffer, John R.; Akeson, Rachel L.; Beichman, Charles A.; Boden, Andrew F.; von Braun, Kaspar; Gelino, Dawn M.; Hoard, D. W.; Howell, Steve B.; Kane, Stephen R.; Plavchan, Peter; Ramírez, Solange V.; Bloom, Joshua S.; Cenko, S. Bradley; Kasliwal, Mansi M.; Kulkarni, Shrinivas R.; Law, Nicholas M.; Nugent, Peter E.; Ofek, Eran O.; Poznanski, Dovi; Quimby, Robert M.; Grillmair, Carl J.; Laher, Russ; Levitan, David; Mattingly, Sean; Surace, Jason A.

2011-08-01

The Palomar Transient Factory (PTF) Orion project is one of the experiments within the broader PTF survey, a systematic automated exploration of the sky for optical transients. Taking advantage of the wide (3fdg5 × 2fdg3) field of view available using the PTF camera installed at the Palomar 48 inch telescope, 40 nights were dedicated in 2009 December to 2010 January to perform continuous high-cadence differential photometry on a single field containing the young (7-10 Myr) 25 Ori association. Little is known empirically about the formation of planets at these young ages, and the primary motivation for the project is to search for planets around young stars in this region. The unique data set also provides for much ancillary science. In this first paper, we describe the survey and the data reduction pipeline, and present some initial results from an inspection of the most clearly varying stars relating to two of the ancillary science objectives: detection of eclipsing binaries and young stellar objects. We find 82 new eclipsing binary systems, 9 of which are good candidate 25 Ori or Orion OB1a association members. Of these, two are potential young W UMa type systems. We report on the possible low-mass (M-dwarf primary) eclipsing systems in the sample, which include six of the candidate young systems. Forty-five of the binary systems are close (mainly contact) systems, and one of these shows an orbital period among the shortest known for W UMa binaries, at 0.2156509 ± 0.0000071 days, with flat-bottomed primary eclipses, and a derived distance that appears consistent with membership in the general Orion association. One of the candidate young systems presents an unusual light curve, perhaps representing a semi-detached binary system with an inflated low-mass primary or a star with a warped disk, and may represent an additional young Orion member. Finally, we identify 14 probable new classical T-Tauri stars in our data, along with one previously known (CVSO 35) and

Inspection of the objects on the sea floor by using 14 MeV tagged neutrons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Valkovic, V.; Sudac, D.; Obhodas, J.

2011-07-01

Variety of objects found on the sea floor needs to be inspected for the presence of materials which represent the threat to the environment and to the safety of humans. We have demonstrated that the sealed tube 14 MeV neutron generator with the detection of associated alpha particles can be used underwater when mounted inside ROV equipped with the hydraulic legs and variety of sensors for the inspection of such objects for the presence of threat materials. Such a system is performing the measurement by using the NaI gamma detector and an API-120 neutron generator which could be rotated inmore » order to maximize the inspected target volume. The neutron beam intensity during the 10-30 min. measurements is usually 1 x 10{sup 7} n/s in 4{pi}. In this report the experimental results for some of commonly found objects containing TNT explosive or its simulant are presented. The measured gamma spectra are dominant by C, O and Fe peaks enabling the determination of the presence of explosives inside the ammunition shell. Parameters influencing the C/O ratio are discussed in some details. (authors)« less

Louisiana Pacific, Tomahawk, Wisconsin; Petition for Objection to Title V Permit

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Petition to Object to Yarnell Mining Company's Title V Operating Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Petition to Object to Edwardsport Generating Station Title V Operating Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Understanding the atmospheric structure of T Tauri stars - II. UV spectroscopy of RY Tau, BP Tau, RU Lupi, GW Ori and CV Cha

NASA Astrophysics Data System (ADS)

Brooks, D. H.; Costa, V. M.; Lago, M. T. V. T.; Lanzafame, A. C.

2001-10-01

We report results from our study of International Ultraviolet Explorer (IUE) data of a group of T Tauri stars (TTS). Comparisons between UV-line fluxes in these stars and in the Sun indicate very high levels of activity in their atmospheres and comparatively higher electron densities. Spectroscopic diagnostic line ratios indicate densities over an order of magnitude higher than in the `quiet' Sun at `transition region' temperatures. At these densities, metastable levels can attain comparable populations to the ground level and ionization fractions can be altered as a result of the sensitivity of dielectronic recombination. In Brooks et al. we improved the treatment of these effects using the adas software package, the atomic models and data of which are based on collisional-radiative theory. Here we extend the analysis to a sample of five TTS: RY Tau, BP Tau, RU Lupi, GW Ori and CV Cha. Using these models and data we derive the emission measure (EM) distribution for each star in the sample. We find that the decrease in EM with increasing temperature appears to be sharper than that found in previous work. In comparison with the Sun, the results suggest that the UV emission is formed in a region with a steeper density or volume gradient. We find mismatches between the theoretical and observed fluxes which cannot be explained by density effects and thus must be a result of uncertainties in the atomic data, unreliabilities in the fluxes or the failure of physical assumptions in the method. We have made a series of tests and comparisons, including examination of opacity effects, and these clearly favour the latter explanation. They also lead us to suggest the presence of two separate components in the UV emission for each of the TTS, although the case of CV Cha is more ambiguous. This supports and extends the earlier work of Jordan & Kuin on RU Lupi. Interestingly, we find that the EM distribution for GW Ori has values at least 10 times larger than those of RY Tau

75 FR 75463 - Clean Air Act Operating Permit Program; Petition To Object to Title V Permit for Luke Paper...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-03

... ENVIROMENTAL PROTECTION AGENCY [FRL-9234-9] Clean Air Act Operating Permit Program; Petition To Object to Title V Permit for Luke Paper Company, Luke, MD AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of final action. SUMMARY: Pursuant to section 505(b)(2) of the Clean Air Act (CAA), the...

Prolongement de théories planétaires à variations séculaires sur plusieurs milliers d'années.

NASA Astrophysics Data System (ADS)

Simon, J. L.

Les théories planétaires à variations séculaires construites au Bureau des Longitudes, VSOP82 (Bretagnon, 1982) et TOP82 (Simon, 1983) ne contiennent pas de termes de degré supérieur à 6 dans le développement en puissance du temps des perturbations. Il en résulte que leur précision se dégrade avec le temps pour des intervalles de temps supérieurs à 1000 ans. L'auteur présente ici un travail effectué en collaboration avec P. Bretagnon qui a consisté à construire une solution du mouvement de Jupiter et Saturne gardant une bonne précision sur 6000 ans.

VizieR Online Data Catalog: Low-mass stars in 25 Ori group and Orion OB1a (Suarez+, 2017)

NASA Astrophysics Data System (ADS)

Suarez, G.; Downes, J. J.; Roman-Zuniga, C.; Covey, K. R.; Tapia, M.; Hernandez, J.; Petr-Gotzens, M. G.; Stassun, K. G.; Briceno, C.

2017-09-01

The V, R, and I photometry used in this work was obtained from the Centro de Investigaciones de Astronomia (CIDA) Deep Survey of Orion (CDSO) catalog (Downes et al. 2014, Cat. J/MNRAS/444/1793), which was constructed by coadding the multi-epoch optical observations from the CIDA Variability Survey of Orion (CVSO; Briceno et al. 2005, Cat. J/AJ/129/907). The sensitivity limits of the CDSO covers the Low-Mass Star (LMS) and Brown Dwarf (BD) population of 25 Ori and its surroundings within the region 79.7°<~α<~82.7° and 0.35°<~δ<~3.35°. The limiting magnitude of the CDSO photometry in this region is Ilim=22 and the completeness magnitude is Icom=19.6 (Downes et al. 2014, Cat. J/MNRAS/444/1793), enough to ensure an I-band detection even for the faintest targets of our spectroscopic sample (I{approx}17.0). Additionally, we used the u, g, r, i, and z photometry from the Sloan Digital Sky Survey (SDSS) catalog (Finkbeiner et al. 2004AJ....128.2577F; Ahn et al. 2012, Cat. V/139). These values are listed in Table1. The Z, Y, J, H, and Ks near-infrared photometry used in this study was carried out by Petr-Gotzens et al. (2011Msngr.145...29P) as part of the Visible and Infrared Survey Telescope for Astronomy (VISTA) science verification surveys (Arnaboldi et al. 2010Msngr.139....6A). The 5σ limiting magnitudes of the VISTA survey of the Orion star-forming region are Z=22.5, Y=21.2, J=20.4, H=19.4, and Ks=18.6, which are enough to have VISTA photometry even for the faintest objects in our spectroscopic sample (J{approx}15.0). Additionally, we used near-infrared photometry from the 2MASS catalog (Cutri et al. 2003, Cat. II/246) and mid-infrared photometry from IRAC-Spitzer (Hernandez et al. 2007, Cat. J/ApJ/671/1784) and the AllWISE catalog (Cutri et al. 2013, Cat. II/328). This infrared photometry is listed in Table1. The spectra used in this paper were obtained as part of the Baryon Oscillation Spectroscopic Survey (BOSS; Dawson et al. 2013AJ....145...10D), which is

A search for T Tauri stars and related objects: Archival photometry of candidate variables in V733 Cep field

NASA Astrophysics Data System (ADS)

Jurdana-Šepić, R.; Poljančić Beljan, I.

Searching for T Tauri stars or related early type variables we carried out a BVRI photometric measurements of five candidates with positions within the field of the pre-main sequence object V733 Cephei (Persson's star) located in the dark cloud L1216 near to Cepheus OB3 Association: VES 946, VES 950, NSV 14333, NSV 25966 and V385 Cep. Their magnitudes are determined on the plates from Asiago Observatory historical photographic archive exposed 1971 - 1978. We provide finding charts for program stars and comparison sequence stars, magnitude estimations, magnitude mean values and BVR_cI_c light curves of program stars.

Learning Objects and Gerontology

ERIC Educational Resources Information Center

Weinreich, Donna M.; Tompkins, Catherine J.

2006-01-01

Virtual AGE (vAGE) is an asynchronous educational environment that utilizes learning objects focused on gerontology and a learning anytime/anywhere philosophy. This paper discusses the benefits of asynchronous instruction and the process of creating learning objects. Learning objects are "small, reusable chunks of instructional media" Wiley…

An UXor among FUors: Extinction-related Brightness Variations of the Young Eruptive Star V582 Aur

NASA Astrophysics Data System (ADS)

Ábrahám, P.; Kóspál, Á.; Kun, M.; Fehér, O.; Zsidi, G.; Acosta-Pulido, J. A.; Carnerero, M. I.; García-Álvarez, D.; Moór, A.; Cseh, B.; Hajdu, G.; Hanyecz, O.; Kelemen, J.; Kriskovics, L.; Marton, G.; Mező, Gy.; Molnár, L.; Ordasi, A.; Rodríguez-Coira, G.; Sárneczky, K.; Sódor, Á.; Szakáts, R.; Szegedi-Elek, E.; Szing, A.; Farkas-Takács, A.; Vida, K.; Vinkó, J.

2018-01-01

V582 Aur is an FU Ori-type young eruptive star in outburst since ∼1985. The eruption is currently in a relatively constant plateau phase, with photometric and spectroscopic variability superimposed. Here we will characterize the progenitor of the outbursting object, explore its environment, and analyze the temporal evolution of the eruption. We are particularly interested in the physical origin of the two deep photometric dips, one that occurred in 2012 and one that is ongoing since 2016. We collected archival photographic plates and carried out new optical, infrared, and millimeter-wave photometric and spectroscopic observations between 2010 and 2018, with a high sampling rate during the current minimum. Besides analyzing the color changes during fading, we compiled multiepoch spectral energy distributions and fitted them with a simple accretion disk model. Based on pre-outburst data and a millimeter continuum measurement, we suggest that the progenitor of the V582 Aur outburst is a low-mass T Tauri star with average properties. The mass of an unresolved circumstellar structure, probably a disk, is 0.04 M ⊙. The optical and near-infrared spectra demonstrate the presence of hydrogen and metallic lines, show the CO band head in absorption, and exhibit a variable Hα profile. The color variations strongly indicate that both the ∼1 yr long brightness dip in 2012 and the current minimum since 2016 are caused by increased extinction along the line of sight. According to our accretion disk models, the reddening changed from A V = 4.5 to 12.5 mag, while the accretion rate remained practically constant. Similarly to the models of the UXor phenomenon of intermediate- and low-mass young stars, orbiting disk structures could be responsible for the eclipses.

NYPIRG Petition to Object to Action Packaging Corp. Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

NYPIRG Petiton to Object to Rochdale Villiage, Inc. Title V Permit

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American Colloid Company, Petition to Object to Title V Operating Permit

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Portland Generating Station, Petition to Object to Title V Operating Permit

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Pacific Custom Materials, Petition to Object to Title V Operating Permit

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Paramount Refinery, Paramount, California; Petition to Object to Title V Operating Permit

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DNA adenine methylation is required to replicate both Vibrio cholerae chromosomes once per cell cycle.

PubMed

Demarre, Gaëlle; Chattoraj, Dhruba K

2010-05-06

DNA adenine methylation is widely used to control many DNA transactions, including replication. In Escherichia coli, methylation serves to silence newly synthesized (hemimethylated) sister origins. SeqA, a protein that binds to hemimethylated DNA, mediates the silencing, and this is necessary to restrict replication to once per cell cycle. The methylation, however, is not essential for replication initiation per se but appeared so when the origins (oriI and oriII) of the two Vibrio cholerae chromosomes were used to drive plasmid replication in E. coli. Here we show that, as in the case of E. coli, methylation is not essential for oriI when it drives chromosomal replication and is needed for once-per-cell-cycle replication in a SeqA-dependent fashion. We found that oriII also needs SeqA for once-per-cell-cycle replication and, additionally, full methylation for efficient initiator binding. The requirement for initiator binding might suffice to make methylation an essential function in V. cholerae. The structure of oriII suggests that it originated from a plasmid, but unlike plasmids, oriII makes use of methylation for once-per-cell-cycle replication, the norm for chromosomal but not plasmid replication.

Examining the predictors of academic outcomes for indigenous Māori, Pacific and rural students admitted into medicine via two equity pathways: a retrospective observational study at the University of Auckland, Aotearoa New Zealand

PubMed Central

Curtis, Elana; Wikaire, Erena; Jiang, Yannan; McMillan, Louise; Loto, Robert; Poole, Phillippa; Barrow, Mark; Bagg, Warwick; Reid, Papaarangi

2017-01-01

Objective To determine associations between admission markers of socioeconomic status, transitioning, bridging programme attendance and prior academic preparation on academic outcomes for indigenous Māori, Pacific and rural students admitted into medicine under access pathways designed to widen participation. Findings were compared with students admitted via the general (usual) admission pathway. Design Retrospective observational study using secondary data. Setting  6-year medical programme (MBChB), University of Auckland, Aotearoa New Zealand. Students are selected and admitted into Year 2 following a first year (undergraduate) or prior degree (graduate). Participants 1676 domestic students admitted into Year 2 between 2002 and 2012 via three pathways: GENERAL admission (1167), Māori and Pacific Admission Scheme—MAPAS (317) or Rural Origin Medical Preferential Entry—ROMPE (192). Of these, 1082 students completed the programme in the study period. Main outcome measures Graduated from medical programme (yes/no), academic scores in Years 2–3 (Grade Point Average (GPA), scored 0–9). Results 735/778 (95%) of GENERAL, 111/121 (92%) of ROMPE and 146/183 (80%) of MAPAS students graduated from intended programme. The graduation rate was significantly lower in the MAPAS students (p<0.0001). The average Year 2–3 GPA was 6.35 (SD 1.52) for GENERAL, which was higher than 5.82 (SD 1.65, p=0.0013) for ROMPE and 4.33 (SD 1.56, p<0.0001) for MAPAS. Multiple regression analyses identified three key predictors of better academic outcomes: bridging programme attendance, admission as an undergraduate and admission GPA/Grade Point Equivalent (GPE). Attending local urban schools and higher school deciles were also associated with a greater likelihood of graduation. All regression models have controlled for predefined baseline confounders (gender, age and year of admission). Conclusions There were varied associations between admission variables and academic outcomes

Antisolar differential rotation with surface lithium enrichment on the single K-giant V1192 Orionis

NASA Astrophysics Data System (ADS)

Kővári, Zs.; Strassmeier, K. G.; Carroll, T. A.; Oláh, K.; Kriskovics, L.; Kővári, E.; Kovács, O.; Vida, K.; Granzer, T.; Weber, M.

2017-10-01

Context. Stars with about 1-2 solar masses at the red giant branch (RGB) represent an intriguing period of stellar evolution, I.e. when the convective envelope interacts with the fast-rotating core. During these mixing episodes freshly synthesized lithium can come up to the stellar surface along with high angular momentum material. This high angular momentum may alter the surface rotation pattern. Aims: The single rapidly rotating K-giant V1192 Ori is revisited to determine its surface differential rotation, lithium abundance, and basic stellar properties such as a precise rotation period. The aim is to independently verify the antisolar differential rotation of the star and possibly find a connection to the surface lithium abundance. Methods: We applied time-series Doppler imaging to a new multi-epoch data set. Altogether we reconstructed 11 Doppler images from spectroscopic data collected with the STELLA robotic telescope between 2007-2016. We used our inversion code iMap to reconstruct all stellar surface maps. We extracted the differential rotation from these images by tracing systematic spot migration as a function of stellar latitude from consecutive image cross-correlations. Results: The position of V1192 Ori in the Hertzsprung-Russell diagram suggests that the star is in the helium core-burning phase just leaving the RGB bump. We measure A(Li)NLTE = 1.27, I.e. a value close to the anticipated transition value of 1.5 from Li-normal to Li-rich giants. Doppler images reveal extended dark areas arranged quasi-evenly along an equatorial belt. No cool polar spot is found during the investigated epoch. Spot displacements clearly suggest antisolar surface differential rotation with α = - 0.11 ± 0.02 shear coefficient. Conclusions: The surface Li enrichment and the peculiar surface rotation pattern may indicate a common origin. Based on data obtained with the STELLA robotic observatory in Tenerife, an AIP facility jointly operated by AIP and IAC.

Hubble imaging of V1331 Cygni: proper motion study of its circumstellar structures

NASA Astrophysics Data System (ADS)

Choudhary, A.; Stecklum, B.; Linz, Hendrik

2016-05-01

Aims: The young star V1331 Cyg received previous attention because it is surrounded by an optical, arc-like reflection nebula. V1331 Cyg is commonly considered to be a candidate for an object that has undergone an FU-Ori (FUOR) outbreak in the past. This in turn could lead to a time-varying appearance of the dusty arcs that may be revealed by multi-epoch imaging. In particular, a radial colour analysis of the dust arcs can then be attempted to check whether the radial grain size distribution was modified by a previous FUOR wind. Methods: Second-epoch imaging of V1331 Cyg was obtained by us in 2009 using the Hubble Space Telescope (HST). By comparing this to archival HST data from 2000, we studied the time evolution of the circumstellar nebulae. After a point spread function subtraction using model point spread functions, we used customised routines to perform a proper motion analysis. The nebula expansion was derived by deconvolving and correlating the two-epoch radial brightness profiles. Additional data from other facilities - TLS, UKIDSS, Spitzer, and Herschel - were also incorporated to improve our understanding of the star in terms of environment, viewing angle, bipolar outflow length, and the FUOR phenomenon. Results: The outer dust arc is found to be expanding at ≈14.8 ± 3.6 km s-1 on average. The expansion velocity for the inner ring is less consistent, between 0.8 km s-1 and 3.0 km s-1. The derived radial colour profiles do not indicate a spatial separation of the dust grain sizes. The Herschel 160 μm images show for the first time thermal emission from dust probably residing in the outer arc. By viewing V1331 Cyg almost pole-on, the length of the bipolar outflow exceeds previous estimates by far. Conclusions: The outer arc expansion timescale is consistent with the implantation time of the CO torus, which supports the hypothesis of an outburst that occurred a few thousand years ago. The azimuthal colour variation of the outer arc is probably due to

Object formation in visual working memory: Evidence from object-based attention.

PubMed

Zhou, Jifan; Zhang, Haihang; Ding, Xiaowei; Shui, Rende; Shen, Mowei

2016-09-01

We report on how visual working memory (VWM) forms intact perceptual representations of visual objects using sub-object elements. Specifically, when objects were divided into fragments and sequentially encoded into VWM, the fragments were involuntarily integrated into objects in VWM, as evidenced by the occurrence of both positive and negative object-based attention effects: In Experiment 1, when subjects' attention was cued to a location occupied by the VWM object, the target presented at the location of that object was perceived as occurring earlier than that presented at the location of a different object. In Experiment 2, responses to a target were significantly slower when a distractor was presented at the same location as the cued object (Experiment 2). These results suggest that object fragments can be integrated into objects within VWM in a manner similar to that of visual perception. Copyright © 2016 Elsevier B.V. All rights reserved.

α-Actinin Promotes Surface Localization and Current Density of the Ca2+ Channel CaV1.2 by Binding to the IQ Region of the α1 Subunit.

PubMed

Tseng, Pang-Yen; Henderson, Peter B; Hergarden, Anne C; Patriarchi, Tommaso; Coleman, Andrea M; Lillya, Mark W; Montagut-Bordas, Carlota; Lee, Boram; Hell, Johannes W; Horne, Mary C

2017-07-18

The voltage-gated L-type Ca 2+ channel Ca V 1.2 is crucial for initiating heartbeat and control of a number of neuronal functions such as neuronal excitability and long-term potentiation. Mutations of Ca V 1.2 subunits result in serious health problems, including arrhythmia, autism spectrum disorders, immunodeficiency, and hypoglycemia. Thus, precise control of Ca V 1.2 surface expression and localization is essential. We previously reported that α-actinin associates and colocalizes with neuronal Ca V 1.2 channels and that shRNA-mediated depletion of α-actinin significantly reduces localization of endogenous Ca V 1.2 in dendritic spines in hippocampal neurons. Here we investigated the hypothesis that direct binding of α-actinin to Ca V 1.2 supports its surface expression. Using two-hybrid screens and pull-down assays, we identified three point mutations (K1647A, Y1649A, and I1654A) in the central, pore-forming α 1 1.2 subunit of Ca V 1.2 that individually impaired α-actinin binding. Surface biotinylation and flow cytometry assays revealed that Ca V 1.2 channels composed of the corresponding α-actinin-binding-deficient mutants result in a 35-40% reduction in surface expression compared to that of wild-type channels. Moreover, the mutant Ca V 1.2 channels expressed in HEK293 cells exhibit a 60-75% decrease in current density. The larger decrease in current density as compared to surface expression imparted by these α 1 1.2 subunit mutations hints at the possibility that α-actinin not only stabilizes surface localization of Ca V 1.2 but also augments its ion conducting activity.

KSC-00pp1647

NASA Image and Video Library

2000-11-07

KENNEDY SPACE CENTER, Fla. -- STS-97 Commander Brent Jett listens to a question from a reporter during a media session near Launch Pad 39B. The crew is at KSC to take part in Terminal Countdown Demonstration Test activities that include emergency egress training, familiarization with the payload, and a simulated launch countdown. The other crew members are Pilot Mike Bloomfield and Mission Specialists Joe Tanner, Marc Garneau and Carlos Noriega. Garneau is with the Canadian Space Agency. Mission STS-97is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:05 p.m. EST

KSC-98pc1647

NASA Image and Video Library

1998-11-12

KENNEDY SPACE CENTER, FLA. -- In the Spacecraft Assembly and Encapsulation Facility -2 (SAEF-2), JPL workers prepare to mount a Mars microprobe onto the Mars Polar Lander. Two microprobes will hitchhike on the lander, scheduled to be launched Jan. 3, 1999, aboard a Delta II rocket. The solar-powered spacecraft is designed to touch down on the Martian surface near the northern-most boundary of the south pole in order to study the water cycle there. The lander also will help scientists learn more about climate change and current resources on Mars, studying such things as frost, dust, water vapor and condensates in the Martian atmosphere. The Mars microprobes, called Deep Space 2, are part of NASA's New Millennium Program. They will complement the climate-related scientific focus of the lander by demonstrating an advanced, rugged microlaser system for detecting subsurface water. Such data on polar subsurface water, in the form of ice, should help put limits on scientific projections for the global abundance of water on Mars

KSC-07pd1647

NASA Image and Video Library

2007-06-26

KENNEDY SPACE CENTER, FLA. -- The Phoenix Mars Lander is on display in the Payload Hazardous Servicing Facility. Phoenix is scheduled to launch Aug. 3 from Launch Pad 17-A at Cape Canaveral Air Force Station. Phoenix will land in icy soils near the north polar permanent ice cap of Mars and explore the history of the water in these soils and any associated rocks, while monitoring polar climate. Landing on Mars is planned in May 2008 on arctic ground where a mission currently in orbit, Mars Odyssey, has detected high concentrations of ice just beneath the top layer of soil. Photo credit: NASA/Kim Shiflett

KSC-02pd1647

NASA Image and Video Library

2002-10-21

KENNEDY SPACE CENTER, FLA. -- An owl is held just before its release during the dedication of the Sendler Education Outpost, located at Dummit Cove on the Merritt Island National Wildlife Refuge (MINWR). The outpost is a resource for environmental educational students in the Central Florida area. It is named for Karl Sendler, a space pioneer and manager under Dr. Kurt Debus, KSC's first center director. Funding for the facility was provided by the Merritt Island Wildlife Association with assistance from MINWR and Kennedy Space Center.

Petition to Object to K-Ply Title V Permit From Bonnie Rathod

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Potlatch Corporation, Order Denying Petition for Objection to Title V Operating Permit

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Petition to Object to Midwest Generation, Romeoville Generating Station Title V Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to Midwest Generation, Joliet Generating Station Title V Permit

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Petition to Object to the GCC Dacotah Portland Cement Title V Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to have the Administrator Object to King Finishing's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Region IV's 1997 Objection to Florida Power and Light Title V Permits

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Midwest Generation, Order Denying Petition for Object to Title V Operating Permits

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

The X-Ray View of Young Stellar Objects

NASA Astrophysics Data System (ADS)

Guedel, Manuel

2007-08-01

X-rays offer ideal access to high-energy phenomena in young, accreting stars. The energy released in magnetic flares has profound effects on the stellar environment. Star-disk magnetic reconnection has been suggested as a possible origin of bipolar jets. Such jets from have been detected at X-ray wavelengths, offering new diagnostics for the energy release and jet shock physics. Finally, eruptive phenomena of FU Ori and EX Lup-type stars have been monitored in X-rays. I will discuss observations and suggest simple models for high-energy eruptive phenomena in young stars.

Electron Transport Chain Is Biochemically Linked to Pilus Assembly Required for Polymicrobial Interactions and Biofilm Formation in the Gram-Positive Actinobacterium Actinomyces oris

PubMed Central

Sanchez, Belkys C.; Chang, Chungyu; Wu, Chenggang; Tran, Bryan

2017-01-01

ABSTRACT The Gram-positive actinobacteria Actinomyces spp. are key colonizers in the development of oral biofilms due to the inherent ability of Actinomyces to adhere to receptor polysaccharides on the surface of oral streptococci and host cells. This receptor-dependent bacterial interaction, or coaggregation, requires a unique sortase-catalyzed pilus consisting of the pilus shaft FimA and the coaggregation factor CafA forming the pilus tip. While the essential role of the sortase machine SrtC2 in pilus assembly, biofilm formation, and coaggregation has been established, little is known about trans-acting factors contributing to these processes. We report here a large-scale Tn5 transposon screen for mutants defective in Actinomyces oris coaggregation with Streptococcus oralis. We obtained 33 independent clones, 13 of which completely failed to aggregate with S. oralis, and the remainder of which exhibited a range of phenotypes from severely to weakly defective coaggregation. The former had Tn5 insertions in fimA, cafA, or srtC2, as expected; the latter were mapped to genes coding for uncharacterized proteins and various nuo genes encoding the NADH dehydrogenase subunits. Electron microscopy and biochemical analyses of mutants with nonpolar deletions of nuo genes and ubiE, a menaquinone C-methyltransferase-encoding gene downstream of the nuo locus, confirmed the pilus and coaggregation defects. Both nuoA and ubiE mutants were defective in oxidation of MdbA, the major oxidoreductase required for oxidative folding of pilus proteins. Furthermore, supplementation of the ubiE mutant with exogenous menaquinone-4 rescued the cell growth and pilus defects. Altogether, we propose that the A. oris electron transport chain is biochemically linked to pilus assembly via oxidative protein folding. PMID:28634238

X-Ray and TeV Gamma-Ray Emission from Parallel Electron-Positron or Electron-Proton Beams in BL Lacertae Objects

NASA Astrophysics Data System (ADS)

Krawczynski, H.

2007-04-01

In this paper we discuss models of the X-ray and TeV γ-ray emission from BL Lac objects based on parallel electron-positron or electron-proton beams that form close to the central black hole, due to the strong electric fields generated by the accretion disk and possibly also by the black hole itself. Fitting the energy spectrum of the BL Lac object Mrk 501, we obtain tight constraints on the beam properties. Launching a sufficiently energetic beam requires rather strong magnetic fields close to the black hole (~100-1000 G). However, the model fits imply that the magnetic field in the emission region is only ~0.02 G. Thus, the particles are accelerated close to the black hole and propagate a considerable distance before instabilities trigger the dissipation of energy through synchrotron and self-Compton emission. We discuss various approaches to generate enough power to drive the jet and, at the same time, to accelerate particles to ~20 TeV energies. Although the parallel beam model has its own problems, it explains some of the long-standing problems that plague models based on Fermi-type particle acceleration, such as the presence of a very high minimum Lorentz factor of accelerated particles. We conclude with a brief discussion of the implications of the model for the difference between the processes of jet formation in BL Lac-type objects and those in quasars.

X-ray and TeV Gamma-Ray Emission from Parallel Electron-Positron or Electron-Proton Beams in BL Lac Objects

NASA Astrophysics Data System (ADS)

Krawczynski, Henric

2007-04-01

In this contribution we discuss models of the X-rays and TeV gamma-ray emission from BL Lac objects based on parallel electron-positron or electron-proton beams that form close to the central black hole owing to the strong electric fields generated by the accretion disk and possibly also by the black hole itself. Fitting the energy spectrum of the BL Lac object Mrk 501, we obtain tight constrains on the beam properties. Launching a sufficiently energetic beam requires rather strong magnetic fields close to the black hole 100-1000 G. However, the model fits imply that the magnetic field in the emission region is only 0.02 G. Thus, the particles are accelerated close to the black hole and propagate a considerable distance before instabilities trigger the dissipation of energy through synchrotron and self-Compton emission. We discuss various approaches to generate enough power to drive the jet and, at the same time, to accelerate particles to 20 TeV energies. Although the parallel beam model has its own problems, it explains some of the long-standing problems that plague models based on Fermi type particle acceleration, like the presence of a very high minimum Lorentz factor of accelerated particles. We conclude with a brief discussion of the implications of the model for the difference between the processes of jet formation in BL Lac type objects and in quasars.

Tradewinds Veneer Mill, Ookala, Hawaii; Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Tradewinds Veneer Mill, Ookala, Hawaii; Petiton to Object to Title V Operating Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Thoroughbred Generating Company; Supplement to Petition to Object to Title V Operating Permit

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Petition to Object to New United Motor Manufacturing, Inc. Title V Operating Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Distributed Object Oriented Programming

DTIC Science & Technology

1990-02-01

of the object oriented model of computation. Therefore, object oriented programming can provide the programmer with good conceptual tools to divide his...LABOR SALES-COMMISSION). The symbol + refers to the addition function and takes any number of numeric arguments. The third subtype of list forms is the...2) ’(:SEND-DONE) (SEWF (AREF OBJECT-i1-MESSAGES-SENT 2) ’(PROGN (FORMAT T "-s methd completely executed instr-ptr -s-V NAME %INSTR-PTR%) (INCF

The Chandra Delta Ori Large Project: Occultation Measurements of the Shocked Gas tn the Nearest Eclipsing O-Star Binary

NASA Technical Reports Server (NTRS)

Corcoran, Michael F.; Nichols, Joy; Naze, Yael; Rauw, Gregor; Pollock, Andrew; Moffat, Anthony; Richardson, Noel; Evans, Nancy; Hamaguchi, Kenji; Oskinova, Lida;

[Depressor anguli oris sign (DAO) in facial paresis. How to search it and release the smile (technical note)].

PubMed

Labbé, D; Bénichou, L; Iodice, A; Giot, J-P

2012-06-01

After facial paralysis recovery, it is common to note a co-contraction between depressor anguli oris (DAO) muscle and zygomatic muscles. This DAO co-contraction will "obstruct" the patient's smile. The purpose of this technical note is to show how to find the DAO sign and how to free up the smile. TECHNICAL: This co-contraction between the zygomatic muscles and DAO research is placing a finger on marionette line, asking the patient to smile: we perceive a rope under the skin corresponding to the abnormal contraction and powerful DAO. A diagnostic test with lidocaine injection into the DAO can be performed to confirm the diagnosis. The treatment of pathological DAO's contraction can be by injection of botulinum toxin in the DAO, or by surgical myectomy. In all cases, a speech therapy complete the treatment. The DAO sign is a semiological entity easy to find. His treatment releases smile without negative effect on the facial expression as the DAO is especially useful in the expression of disgust. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

25 Orionis: A Kinematically Distinct 10 Myr Old Group in Orion OB1a

NASA Astrophysics Data System (ADS)

Briceño, César; Hartmann, Lee; Hernández, Jesús; Calvet, Nuria; Vivas, A. Katherina; Furesz, Gabor; Szentgyorgyi, Andrew

2007-06-01

We report here on the photometric and kinematic properties of a well-defined group of nearly 200 low-mass pre-main-sequence stars, concentrated within ~1° of the early-B star 25 Ori, in the Orion OB1a subassociation. We refer to this stellar aggregate as the 25 Orionis group. The group also harbors the Herbig Ae/Be star V346 Ori and a dozen other early-type stars with photometry, parallaxes, and some with IR excess emission, indicative of group membership. The number of high- and low-mass stars is in agreement with expectations from a standard initial mass function. The velocity distribution for the low-mass stars shows a narrow peak at 19.7 km s-1, offset ~-10 km s-1 from the velocity characterizing the younger stars of the Ori OB1b subassociation, and -4 km s-1 from the velocity of widely spread young stars of the Ori OB1a population; this result provides new and compelling evidence that the 25 Ori group is a distinct kinematic entity, and that considerable space and velocity structure is present in the Ori OB1a subassociation. The low-mass members follow a well-defined band in the color-magnitude diagram, consistent with an isochronal age of ~7-10 Myr. The ~2 time drop in the overall Li I equivalent widths and accretion fraction between the younger Ori OB1b and the 25 Ori group is consistent with the latter being significantly older. In a simple-minded kinematic evolution scenario, the 25 Ori group may represent the evolved counterpart of the younger σ Ori cluster. The 25 Ori stellar aggregate is the most populous ~10 Myr sample yet known within 500 pc, setting it as an excellent laboratory to study the evolution of solar-like stars and protoplanetary disks. Based on observations obtained at the Llano del Hato National Astronomical Observatory of Venezuela, operated by CIDA for the Ministerio de Ciencia y Tecnología the MMT Observatory, a joint facility of the Smithsonian Institution and the University of Arizona; and the Fred Lawrence Whipple Observatory of

Ethnic Disparities in CPAP Adherence in New Zealand: Effects of Socioeconomic Status, Health Literacy and Self-Efficacy

PubMed Central

Bakker, Jessie P.; O'Keeffe, Karyn M.; Neill, Alister M.; Campbell, Angela J.

2011-01-01

Study Objectives: We aimed to investigate the influence of ethnicity on adherence with continuous positive airway pressure (CPAP) in a sample of New Zealand patients. Design: Observational study over one month. Setting: A university-based sleep laboratory. Patients: 126 consecutively consenting CPAP-naïve patients (19.8% Māori, mean±SD apnea-hypopnea index 57.9 ± 38.9 events/h, CPAP 11.1 ± 3.1 cm H2O). Interventions: Patients underwent a 4-week supervised home trial of CPAP following pressure titration. Measurements and Results: Self-identified ethnicity (Māori/non-Māori), Epworth Sleepiness Scale, Self-Efficacy Measure for Sleep Apnea, Rapid Estimate of Adult Literacy in Medicine, New Zealand Deprivation Index (calculated from residential address), New Zealand Individual Deprivation Index (validated 8-item questionnaire), educational history, income, and employment assessed at baseline were compared to objective CPAP adherence after one month. Māori demonstrated significantly lower usage than non-Māori (median 5.11, interquartile range 2.24 h/night compared with median 5.71, interquartile range 2.61 h/night, P = 0.05). There were no significant relationships between adherence and subjective sleepiness, health literacy, or self-efficacy. In a multivariate logistic regression model incorporating 5 variables (ethnicity, eligibility for government-subsidized healthcare, individual deprivation scores, income, and education), non-completion of tertiary education, and high individual socioeconomic deprivation remained significant independent predictors of average CPAP adherence not reaching ≥ 4 h (odds ratio 0.25, 95% CI 0.08-0.83, P = 0.02; odds ratio 0.10, 95% CI 0.02-0.86, P = 0.04, respectively). The overall model explained approximately 23% of the variance in adherence. Conclusions: The disparity in CPAP adherence demonstrated between Māori and non-Māori can be explained in part by lower education levels and socioeconomic status. Citation: Bakker JP; O

Variable X-ray Emission from FU Orionis

NASA Astrophysics Data System (ADS)

Skinner, Steve L.; Guedel, M.; Briggs, K. R.; Lamzin, S. A.; Sokal, K. R.

2009-05-01

FU Orionis is the prototype of a small but remarkable class of pre-main sequence stars ('FUors') that have undergone large optical outbursts thought to be linked to episodic accretion. FU Ori increased in optical brightness by about 6 mag in 1936-37 and is still in slow decline. Because of their high accretion rates, FUors are good candidates for exploring potential effects of accretion on X-ray emission. A recently completed survey of FUors with XMM-Newton detected X-rays from FU Ori and V1735 Cyg. We present new results from a sensitive 99 ksec (1.15 day) follow-up X-ray observation of FU Ori with Chandra. The Chandra ACIS-S CCD spectrum confirms the presence of a cool plasma component (kT < 1 keV) viewed under moderate absorption and a much hotter component (kT > 3 keV), viewed under high absorption, in accord with previous XMM results. The uninterrupted Chandra light curve shows that the hot component is slowly variable on a timescale of one day, but no variability is detected in the cool component. The slow variability and high plasma temperature point to a magnetic origin for the hot component, but other mechanisms (including accretion) may be responsible for the cool non-variable component. We will discuss these new results in the context of what is known about FU Ori from previous observations, including XMM (Skinner et al. 2006, ApJ, 643, 995) and HST (Kravtsova et al. 2007, Ast. Ltrs., 33, 755).

Optical polarization of high-energy BL Lacertae objects

NASA Astrophysics Data System (ADS)

Hovatta, T.; Lindfors, E.; Blinov, D.; Pavlidou, V.; Nilsson, K.; Kiehlmann, S.; Angelakis, E.; Fallah Ramazani, V.; Liodakis, I.; Myserlis, I.; Panopoulou, G. V.; Pursimo, T.

2016-12-01

Context. We investigate the optical polarization properties of high-energy BL Lac objects using data from the RoboPol blazar monitoring program and the Nordic Optical Telescope. Aims: We wish to understand if there are differences between the BL Lac objects that have been detected with the current-generation TeV instruments and those objects that have not yet been detected. Methods: We used a maximum-likelihood method to investigate the optical polarization fraction and its variability in these sources. In order to study the polarization position angle variability, we calculated the time derivative of the electric vector position angle (EVPA) change. We also studied the spread in the Stokes Q/I-U/I plane and rotations in the polarization plane. Results: The mean polarization fraction of the TeV-detected BL Lacs is 5%, while the non-TeV sources show a higher mean polarization fraction of 7%. This difference in polarization fraction disappears when the dilution by the unpolarized light of the host galaxy is accounted for. The TeV sources show somewhat lower fractional polarization variability amplitudes than the non-TeV sources. Also the fraction of sources with a smaller spread in the Q/I-U/I plane and a clumped distribution of points away from the origin, possibly indicating a preferred polarization angle, is larger in the TeV than in the non-TeV sources. These differences between TeV and non-TeV samples seem to arise from differences between intermediate and high spectral peaking sources instead of the TeV detection. When the EVPA variations are studied, the rate of EVPA change is similar in both samples. We detect significant EVPA rotations in both TeV and non-TeV sources, showing that rotations can occur in high spectral peaking BL Lac objects when the monitoring cadence is dense enough. Our simulations show that we cannot exclude a random walk origin for these rotations. Conclusions: These results indicate that there are no intrinsic differences in the

Impaired integration of object knowledge and visual input in a case of ventral simultanagnosia with bilateral damage to area V4.

PubMed

Leek, E Charles; d'Avossa, Giovanni; Tainturier, Marie-Josèphe; Roberts, Daniel J; Yuen, Sung Lai; Hu, Mo; Rafal, Robert

2012-01-01

This study examines how brain damage can affect the cognitive processes that support the integration of sensory input and prior knowledge during shape perception. It is based on the first detailed study of acquired ventral simultanagnosia, which was found in a patient (M.T.) with posterior occipitotemporal lesions encompassing V4 bilaterally. Despite showing normal object recognition for single items in both accuracy and response times (RTs), and intact low-level vision assessed across an extensive battery of tests, M.T. was impaired in object identification with overlapping figures displays. Task performance was modulated by familiarity: Unlike controls, M.T. was faster with overlapping displays of abstract shapes than with overlapping displays of common objects. His performance with overlapping common object displays was also influenced by both the semantic relatedness and visual similarity of the display items. These findings challenge claims that visual perception is driven solely by feedforward mechanisms and show how brain damage can selectively impair high-level perceptual processes supporting the integration of stored knowledge and visual sensory input.

Columbia Gerating Station, Pardeeville, Wisonconsin Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Portland Generating Station, Order Denying Petition for Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition Requesting the Administrator Object to Title V Permit for ABC Coke Facility

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Region 4 Formal Objection to the Century Aluminum of Kentucky Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Kerr-McGee Frederick Station, Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition Requesting the Administrator Object to Goldendale Generating Station Title V Operating Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

University of Wisconsin Madison Heating Plant - Petition to Object to Title V Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

U.S. Steel Keewatin Taconite Plant - Petition to Object to Title V Permit

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Denver Regional Landfill South, Order Denying Petition for Objection to Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to K-Ply's Title V Permit From Barbara T. Osborne

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This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

East Kentucky Power Cooperative Spurlock Station; Petition to Object to Title V Operating Permit

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Louisville Gas & Electric Trimble Power Station; Petition to Object to REVISED Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Premcor Refining Group, Port Arthur, Texas; Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

ConocoPhillips Wilmington Refinery, Wilmington, California; Petiton to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Cemex, Inc., Lyons, Colorado; Petition to Object (or reopen) to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Tennessee Valley Authority, Paradise Fossil Plant; Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Effectiveness of γ-oryzanol in reducing neuromotor deficits, dopamine depletion and oxidative stress in a Drosophila melanogaster model of Parkinson's disease induced by rotenone.

PubMed

Araujo, Stífani Machado; de Paula, Mariane Trindade; Poetini, Marcia Rósula; Meichtry, Luana; Bortolotto, Vandreza Cardoso; Zarzecki, Micheli Stefani; Jesse, Cristiano Ricardo; Prigol, Marina

2015-12-01

The γ-orizanol present in rice bran oil contains a mix of steryl triterpenyl esters of ferulic acid, which is believed to be linked to its antioxidant potential. In this study we investigated the neuroprotective actions of γ-orizanol (ORY) against the toxicity induced by rotenone (ROT) in Drosophila melanogaster. The flies (both genders) aged between 1 and 5 days old were divided into four groups of 50 flies each: (1) control, (2) ORY 25 μM, (3) ROT 500 μM, (4) ORY 25 μM+ROT 500 μM. Flies were concomitantly exposed to a diet containing ROT and ORY for 7 days according to their respective groups. Survival and behavior analyses were carried out in vivo, and ex vivo analyses involved acetylcholinesterase activity (AChE), determination of dopaminergic levels, cellular viability and mitochondrial viability, activities of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), reactive species levels (RS), lipid peroxidation (TBARS) and contents of total thiols and non-proteic thiols (NPSH). Our results show for the first time that ORY not only acts as an endogenous activator of the cellular antioxidant defenses, but it also ameliorates rotenone induced mortality, oxidative stress and mitochondrial dysfunction. Our salient findings regarded the restoration of cholinergic deficits, dopamine levels and improved motor function provided by ORY. These results demonstrate the neuroprotective potential of ORY and that this effect can be potentially due to its antioxidant action. In conclusion, the present results show that ORY is effective in reducing the ROT induced toxicity in D. melanogaster, which showed a neuroprotective action, possibly due to the presence of the antioxidant constituents such as the ferulic acid. Copyright © 2015. Published by Elsevier B.V.

Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men.

PubMed

Tanner, Callum; Boocock, James; Stahl, Eli A; Dobbyn, Amanda; Mandal, Asim K; Cadzow, Murray; Phipps-Green, Amanda J; Topless, Ruth K; Hindmarsh, Jennie Harré; Stamp, Lisa K; Dalbeth, Nicola; Choi, Hyon K; Mount, David B; Merriman, Tony R

2017-07-01

There is no evidence for a genetic association between organic anion transporters 1-3 (SLC22A6, SLC22A7, and SLC22A8) and multidrug resistance protein 4 (MRP4; encoded by ABCC4) with the levels of serum urate or gout. The Māori and Pacific (Polynesian) population of New Zealand has the highest prevalence of gout worldwide. The aim of this study was to determine whether any Polynesian population-specific genetic variants in SLC22A6-8 and ABCC4 are associated with gout. All participants had ≥3 self-reported Māori and/or Pacific grandparents. Among the total sample set of 1,808 participants, 191 hyperuricemic and 202 normouricemic individuals were resequenced over the 4 genes, and the remaining 1,415 individuals were used for replication. Regression analyses were performed, adjusting for age, sex, and Polynesian ancestry. To study the functional effect of nonsynonymous variants of ABCC4, transport assays were performed in Xenopus laevis oocytes. A total of 39 common variants were detected, with an ABCC4 variant (rs4148500) significantly associated with hyperuricemia and gout. This variant was monomorphic for the urate-lowering allele in Europeans. There was evidence for an association of rs4148500 with gout in the resequenced samples (odds ratio [OR] 1.62 [P = 0.012]) that was replicated (OR 1.25 [P = 0.033]) and restricted to men (OR 1.43 [P = 0.001] versus OR 0.98 [P = 0.89] in women). The gout risk allele was associated with fractional excretion of uric acid in male individuals (β = -0.570 [P = 0.01]). A rare population-specific allele (P1036L) with predicted strong functional consequence reduced the uric acid transport activity of ABCC4 by 30%. An association between ABCC4 and gout and fractional excretion of uric acid is consistent with the established role of MRP4 as a unidirectional renal uric acid efflux pump. © 2017, American College of Rheumatology.

PROPLYDS AROUND A B1 STAR: 42 ORIONIS IN NGC 1977

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Jinyoung Serena; Fang, Min; Clarke, Cathie J.

2016-07-20

We present the discovery of seven new proplyds (i.e., sources surrounded by cometary H α emission characteristic of offset ionization fronts (IFs)) in NGC 1977, located about 30′ north of the Orion Nebula Cluster (ONC) at a distance of ∼400 pc. Each of these proplyds is situated at projected distances 0.04–0.27 pc from the B1V star 42 Orionis ( c Ori), which is the main source of UV photons in the region. In all cases the IFs of the proplyds are clearly pointing toward the common ionizing source, 42 Ori, and six of the seven proplyds clearly show tails pointingmore » away from it. These are the first proplyds to be found around a B star, with previously known examples instead being located around O stars, including those in the ONC around θ {sup 1} Ori C. The radii of the offset IFs in our proplyds are between ∼200 and 550 au; two objects also contain clearly resolved central sources that we associate with disks of radii 50–70 au. The estimated strength of the FUV radiation field impinging on the proplyds is around 10–30 times less than that incident on the classic proplyds in the ONC. We show that the observed proplyd sizes are however consistent with recent models for FUV photoevaporation in relatively weak FUV radiation fields.« less

Seeing Objects as Faces Enhances Object Detection.

PubMed

Takahashi, Kohske; Watanabe, Katsumi

2015-10-01

The face is a special visual stimulus. Both bottom-up processes for low-level facial features and top-down modulation by face expectations contribute to the advantages of face perception. However, it is hard to dissociate the top-down factors from the bottom-up processes, since facial stimuli mandatorily lead to face awareness. In the present study, using the face pareidolia phenomenon, we demonstrated that face awareness, namely seeing an object as a face, enhances object detection performance. In face pareidolia, some people see a visual stimulus, for example, three dots arranged in V shape, as a face, while others do not. This phenomenon allows us to investigate the effect of face awareness leaving the stimulus per se unchanged. Participants were asked to detect a face target or a triangle target. While target per se was identical between the two tasks, the detection sensitivity was higher when the participants recognized the target as a face. This was the case irrespective of the stimulus eccentricity or the vertical orientation of the stimulus. These results demonstrate that seeing an object as a face facilitates object detection via top-down modulation. The advantages of face perception are, therefore, at least partly, due to face awareness.

Seeing Objects as Faces Enhances Object Detection

PubMed Central

Watanabe, Katsumi

2015-01-01

The face is a special visual stimulus. Both bottom-up processes for low-level facial features and top-down modulation by face expectations contribute to the advantages of face perception. However, it is hard to dissociate the top-down factors from the bottom-up processes, since facial stimuli mandatorily lead to face awareness. In the present study, using the face pareidolia phenomenon, we demonstrated that face awareness, namely seeing an object as a face, enhances object detection performance. In face pareidolia, some people see a visual stimulus, for example, three dots arranged in V shape, as a face, while others do not. This phenomenon allows us to investigate the effect of face awareness leaving the stimulus per se unchanged. Participants were asked to detect a face target or a triangle target. While target per se was identical between the two tasks, the detection sensitivity was higher when the participants recognized the target as a face. This was the case irrespective of the stimulus eccentricity or the vertical orientation of the stimulus. These results demonstrate that seeing an object as a face facilitates object detection via top-down modulation. The advantages of face perception are, therefore, at least partly, due to face awareness. PMID:27648219

Long-term Optical Activity of the Hard X-ray Flaring Star DG CVn

NASA Astrophysics Data System (ADS)

Šimon, V.

2017-04-01

DG CVn is a young late-type star which displayed an X-ray and optical superflare in 2014. This paper presents an analysis of the long-term activity of this object in the optical band. I used the photographic data from DASCH (Digital Access to a Sky Century @ Harvard). These measurements from the years 1895-1989 cover the blue spectral region. CCD V-band ASAS data were used for several UV Cet-type stars to place the activity of DG CVn in the context of flaring stars. I show that three large brightenings (flares) of DG CVn by more than 1 mag were detected on the DASCH plates. The character of the long-term activity (regarding the histogram of brightness) of DG CVn is compatible with those of flaring stars UV Cet and V371 Ori. The flares brighter than ˜ 0.4 mag represent less than 1 percent of the observed data in all three objects

HST/STIS ULTRAVIOLET SPECTROSCOPY OF THE COMPONENTS OF THE MASSIVE TRIPLE STAR δ ORI A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richardson, Noel D.; Moffat, Anthony F. J.; Gull, Theodore R.

2015-07-20

The multiple star system of δ Orionis is one of the closest examples of a system containing a luminous O-type, bright giant star (component Aa1). It is often used as a spectral-type standard and has the highest observed X-ray flux of any hot-star binary. The main component Aa1 is orbited by two lower mass stars, faint Aa2 in a 5.7 day eclipsing binary, and Ab, an astrometric companion with an estimated period of 346 years. Generally the flux from all three stars is recorded in ground-based spectroscopy, and the spectral decomposition of the components has proved difficult. Here we presentmore » Hubble Space Telescope/Space Telescope Imaging Spectrograph ultraviolet spectroscopy of δ Ori A that provides us with spatially separated spectra of Aa and Ab for the first time. We measured radial velocities for Aa1 and Ab in two observations made near the velocity extrema of Aa1. We show tentative evidence for the detection of the Aa2 component in cross-correlation functions of the observed and model spectra. We discuss the appearance of the UV spectra of Aa1 and Ab with reference to model spectra. Both stars have similar effective temperatures, but Ab is fainter and is a rapid rotator. The results will help in the interpretation of ground-based spectroscopy and in understanding the physical and evolutionary parameters of these massive stars.« less

Dose planning objectives in anal canal cancer IMRT: the TROG ANROTAT experience

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Elizabeth, E-mail: elizabeth@mebrown.net; Cray, Alison; Haworth, Annette

2015-06-15

Intensity modulated radiotherapy (IMRT) is ideal for anal canal cancer (ACC), delivering high doses to irregular tumour volumes whilst minimising dose to surrounding normal tissues. Establishing achievable dose objectives is a challenge. The purpose of this paper was to utilise data collected in the Assessment of New Radiation Oncology Treatments and Technologies (ANROTAT) project to evaluate the feasibility of ACC IMRT dose planning objectives employed in the Australian situation. Ten Australian centres were randomly allocated three data sets from 15 non-identifiable computed tomography data sets representing a range of disease stages and gender. Each data set was planned by twomore » different centres, producing 30 plans. All tumour and organ at risk (OAR) contours, prescription and dose constraint details were provided. Dose–volume histograms (DVHs) for each plan were analysed to evaluate the feasibility of dose planning objectives provided. All dose planning objectives for the bone marrow (BM) and femoral heads were achieved. Median planned doses exceeded one or more objectives for bowel, external genitalia and bladder. This reached statistical significance for bowel V30 (P = 0.04), V45 (P < 0.001), V50 (P < 0.001), external genitalia V20 (P < 0.001) and bladder V35 (P < 0.001), V40 (P = 0.01). Gender was found to be the only significant factor in the likelihood of achieving the bowel V50 (P = 0.03) and BM V30 constraints (P = 0.04). The dose planning objectives used in the ANROTAT project provide a good starting point for ACC IMRT planning. To facilitate clinical implementation, it is important to prioritise OAR objectives and recognise factors that affect the achievability of these objectives.« less

Exploring the relationship between object realism and object-based attention effects.

PubMed

Roque, Nelson; Boot, Walter R

2015-09-01

Visual attention prioritizes processing of locations in space, and evidence also suggests that the benefits of attention can be shaped by the presence of objects (object-based attention). However, the prevalence of object-based attention effects has been called into question recently by evidence from a large-sampled study employing classic attention paradigms (Pilz et al., 2012). We conducted two experiments to explore factors that might determine when and if object-based attention effects are observed, focusing on the degree to which the concreteness and realism of objects might contribute to these effects. We adapted the classic attention paradigm first reported by Egly, Driver, and Rafal (1994) by replacing abstract bar stimuli in some conditions with objects that were more concrete and familiar to participants: items of silverware. Furthermore, we varied the realism of these items of silverware, presenting either cartoon versions or photo-realistic versions. Contrary to predictions, increased realism did not increase the size of object-based effects. In fact, no clear object-based effects were observed in either experiment, consistent with previous failures to replicate these effects in similar paradigms. While object-based attention may exist, and may have important influences on how we parse the visual world, these and other findings suggest that the two-object paradigm typically relied upon to study object-based effects may not be the best paradigm to investigate these issues. Copyright © 2015 Elsevier B.V. All rights reserved.

Texes Observations of M Supergiants: Dynamics and Thermodynamics of Wind Acceleration

NASA Astrophysics Data System (ADS)

Harper, Graham M.; Richter, Matthew J.; Ryde, Nils; Brown, Alexander; Brown, Joanna; Greathouse, Thomas K.; Strong, Shadrian

2009-08-01

We have detected [Fe II] 17.94 μm and 24.52 μm emission from a sample of M supergiants (μ Cep, α Sco, α Ori, CE Tau, AD Per, and α Her) using the Texas Echelon Cross Echelle Spectrograph on NASA's Infrared Telescope Facility. These low opacity emission lines are resolved at R sime 50, 000 and provide new diagnostics of the dynamics and thermodynamics of the stellar wind acceleration zone. The [Fe II] lines, from the first excited term (a 4 F), are sensitive to the warm plasma where energy is deposited into the extended atmosphere to form the chromosphere and wind outflow. These diagnostics complement previous Kuiper Airborne Observatory and Infrared Space Observatory observations which were sensitive to the cooler and more extended circumstellar envelopes. The turbulent velocities of V turb sime 12-13 km s-1 observed in the [Fe II] a 4 F forbidden lines are found to be a common property of our sample, and are less than that derived from the hotter chromospheric C II] 2325 Å lines observed in α Ori, where V turb sime 17-19 km s-1. For the first time, we have dynamically resolved the motions of the dominant cool atmospheric component discovered in α Ori from multiwavelength radio interferometry by Lim et al. Surprisingly, the emission centroids are quite Gaussian and at rest with respect to the M supergiants. These constraints combined with model calculations of the infrared emission line fluxes for α Ori imply that the warm material has a low outflow velocity and is located close to the star. We have also detected narrow [Fe I] 24.04 μm emission that confirms Fe II is the dominant ionization state in α Ori's extended atmosphere.

Sierra Club's Petition to Have the Administrator Object to Citgo Doraville's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Prime Energy Limited Partnership, Dismissal of Untimely Petition to Object to Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to Title V Permit, Louis Dreyfus Agricultural Industries Oil-Seed Plant

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to the VIM Recycling, Inc., Elkhart, Indiana, Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition Requesting that the Administrator Object to Dunkirk Steam Generating Station's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition for the Administrator to Object to Title V Permit for Walter Coke Facility

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to the Luke Paper Company, Luke, Maryland, Title V Operation Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Pope and Talbot, Inc., Petition for Objection to Issuance of Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Sierra Club's Petition to Have the Administrator Object to Dougherty Landfill's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to have the Administrator Object to Anchor Glass Container Corporation's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Order Denying Petition to Object to CITGO Petroleum Corporation's Doraville Terminal Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Order Deneying the Petition to Object to Title V Permit for Edwardsport Generating Station

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Sierra Club's Petition to Have the Administrator Object to Seminole Landfill's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition Requesting the Administrator Object to Title V Operating Permit for Gateway Generating Station

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

December 29, 2003 Petition Requesting the Administrator Object to Titanium Metals Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition requesting that the Administrator Object to Huntley Steam Generating Plant's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Order Responding to Petitions Requesting that the Admisistrator Object to Three Title V Permits

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Denver Regional Landfill South, Petition for Objection to Issuance of Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to Wisconsin Electric's Valley Power Plant, Milwaukee, Wisconsin, Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Objection to the Revised Hugh L. Spurlock Generating Station, Maysville, Kentucky, Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to have the Administrator Object to Weyerhaeuser - Barnesville Wood Products Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to Wheelabrator Baltimore, L.P., Baltimore, MD Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

ConocoPhillips Wilmington Refinery, Wilmington, California; 2008 Petiton to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Waupaca Foundry Plants 2 and 3; Order Denying Petition for Object to Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

2001 Petition Requesting the Administrator Object to Title V Permit For Los Medanos Energy Center

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

American Education's Beginnings

ERIC Educational Resources Information Center

Hazlett, Lisa A.

2011-01-01

Compulsory education in America arguably originated with Massachusetts's legislative acts of 1642, 1647, and 1648; the 1642 act compelled education of children. Best known is the colorfully named Old Deluder Satan Law of 1647, famously declaring towns with populations of 50 must hire a reading and writing teacher, and those holding 100 requiring a…

V-type candidates and Vesta family asteroids in the Moving Objects VISTA (MOVIS) catalogue

NASA Astrophysics Data System (ADS)

Licandro, J.; Popescu, M.; Morate, D.; de León, J.

2017-04-01

Context. Basaltic asteroids (spectrally classified as V-types) are believed to be fragments of large differentiated bodies. The majority of them are found in the inner part of the asteroid belt, and are current or past members of the Vesta family. Recently, some V-type asteroids have been discovered far from the Vesta family supporting the hypothesis of the presence of multiple basaltic asteroids in the early solar system. The discovery of basaltic asteroids in the outer belt challenged the models of the radial extent and the variability of the temperature distribution in the early solar system. Aims: We aim to identify new basaltic V-type asteroids using near-infrared colors of 40 000 asteroids observed by the VHS-VISTA survey and compiled in the MOVIS-C catalogue. We also want to study their near-infrared colors and to study the near-infrared color distribution of the Vesta dynamical family. Methods: We performed a search in the MOVIS-C catalogue of all the asteroids with (Y-J) and (J-Ks) in the range (Y-J) ≥ 0.5 and (J-Ks) ≤ 0.3, associated with V-type asteroids, and studied their color distribution. We have also analyzed the near-infrared color distribution of 273 asteroid members of the Vesta family and compared them with the albedo and visible colors from WISE and SDSS data. We determined the fraction of V-type asteroids in the family. Results: We found 477 V-type candidates in MOVIS-C, 244 of them outside the Vesta dynamical family. We identified 19 V-type asteroids beyond the 3:1 mean motion resonance, 6 of them in the outer main belt, and 16 V-types in the inner main belt with proper inclination Ip ≤ 3.0°, well below the inclination of the Vesta family. We computed that 85% of the members of the Vesta dynamical family are V-type asteroids, and only 1-2% are primitive class asteroids and unlikely members of the family. Conclusions: This work almost doubles the sample of basaltic asteroid candidates in regions outside the Vesta family. Spectroscopic

Code Verification Capabilities and Assessments in Support of ASC V&V Level 2 Milestone #6035

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doebling, Scott William; Budzien, Joanne Louise; Ferguson, Jim Michael

This document provides a summary of the code verification activities supporting the FY17 Level 2 V&V milestone entitled “Deliver a Capability for V&V Assessments of Code Implementations of Physics Models and Numerical Algorithms in Support of Future Predictive Capability Framework Pegposts.” The physics validation activities supporting this milestone are documented separately. The objectives of this portion of the milestone are: 1) Develop software tools to support code verification analysis; 2) Document standard definitions of code verification test problems; and 3) Perform code verification assessments (focusing on error behavior of algorithms). This report and a set of additional standalone documents servemore » as the compilation of results demonstrating accomplishment of these objectives.« less

Resolving human object recognition in space and time

PubMed Central

Cichy, Radoslaw Martin; Pantazis, Dimitrios; Oliva, Aude

2014-01-01

A comprehensive picture of object processing in the human brain requires combining both spatial and temporal information about brain activity. Here, we acquired human magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) responses to 92 object images. Multivariate pattern classification applied to MEG revealed the time course of object processing: whereas individual images were discriminated by visual representations early, ordinate and superordinate category levels emerged relatively later. Using representational similarity analysis, we combine human fMRI and MEG to show content-specific correspondence between early MEG responses and primary visual cortex (V1), and later MEG responses and inferior temporal (IT) cortex. We identified transient and persistent neural activities during object processing, with sources in V1 and IT., Finally, human MEG signals were correlated to single-unit responses in monkey IT. Together, our findings provide an integrated space- and time-resolved view of human object categorization during the first few hundred milliseconds of vision. PMID:24464044

Search and characterization of T-type planetary mass candidates in the σ Orionis cluster

NASA Astrophysics Data System (ADS)

Peña Ramírez, K.; Zapatero Osorio, M. R.; Béjar, V. J. S.; Rebolo, R.; Bihain, G.

2011-08-01

Context. The proper characterization of the least massive population of the young σ Orionis star cluster is required to understand the form of the cluster mass function and its impact on our comprehension of the substellar formation processes. S Ori 70 (T5.5 ± 1) and 73, two T-type cluster member candidates, are likely to have masses between 3 and 7 MJup if their age is 3 Myr. It awaits confirmation whether S Ori 73 has a methane atmosphere. Aims: We aim to: i) confirm the presence of methane absorption in S Ori 73 by performing methane imaging; ii) study S Ori 70 and 73 cluster membership via photometric colors and accurate proper motion analysis; and iii) perform a new search to identify additional T-type σ Orionis member candidates. Methods: We obtained HAWK-I (VLT) J, H, and CH4off photometry of an area of 119.15 arcmin2 in σ Orionis down to Jcomp = 21.7 and Hcomp = 21 mag. S Ori 70 and 73 are contained in the explored area. Near-infrared data were complemented with optical photometry using images acquired with OSIRIS (GTC) and VISTA as part of the VISTA Orion survey. Color-magnitude and color-color diagrams were constructed to characterize S Ori 70 and 73 photometrically, and to identify new objects with methane absorption and masses below 7 MJup. We derived proper motions by comparing of the new HAWK-I and VISTA images with published near-infrared data taken 3.4 - 7.9 yr ago. Results.S Ori 73 has a red H - CH4off color indicating methane absorption in the H-band and a spectral type of T4 ± 1. S Ori 70 displays a redder methane color than S Ori 73 in agreement with its latter spectral classification. Our proper motion measurements (μα cos δ = 26.7 ± 6.1, μδ = 21.3 ± 6.1 mas yr-1 for S Ori 70, and μα cos δ = 46.7 ± 4.9, μδ = -6.3 ± 4.7 mas yr-1 for S Ori 73) are larger than the motion of σ Orionis, rendering S Ori 70 and 73 cluster membership uncertain. From our survey, we identified one new photometric candidate with J = 21.69 ± 0.12 mag

Mass Transport from the Envelope to the Disk of V346 Nor: A Case Study for the Luminosity Problem in an FUor-type Young Eruptive Star

NASA Astrophysics Data System (ADS)

Kóspál, Á.; Ábrahám, P.; Csengeri, T.; Fehér, O.; Hogerheijde, M. R.; Brinch, Ch.; Dunham, M. M.; Vorobyov, E. I.; Salter, D. M.; Henning, Th.

2017-07-01

A long-standing open issue of the paradigm of low-mass star formation is the luminosity problem: most protostars are less luminous than theoretically predicted. One possible solution is that the accretion process is episodic. FU Ori-type stars (FUors) are thought to be the visible examples for objects in the high accretion state. FUors are often surrounded by massive envelopes, which replenish the disk material and enable the disk to produce accretion outbursts. However, we have insufficient information on the envelope dynamics in FUors, about where and how mass transfer from the envelope to the disk happens. Here we present ALMA observations of the FUor-type star V346 Nor at 1.3 mm continuum and in different CO rotational lines. We mapped the density and velocity structure of its envelope and analyze the results using channel maps, position-velocity diagrams, and spectro-astrometric methods. We found that V346 Nor is surrounded by gaseous material on a 10,000 au scale in which a prominent outflow cavity is carved. Within the central ˜700 au, the circumstellar matter forms a flattened pseudo-disk where material is infalling with conserved angular momentum. Within ˜350 au, the velocity profile is more consistent with a disk in Keplerian rotation around a central star of 0.1 {M}⊙ . We determined an infall rate from the envelope onto the disk of 6× {10}-6 {M}⊙ yr-1, a factor of a few higher than the quiescent accretion rate from the disk onto the star, hinting at a mismatch between the infall and accretion rates as the cause of the eruption.

A Cortical Network for the Encoding of Object Change

PubMed Central

Hindy, Nicholas C.; Solomon, Sarah H.; Altmann, Gerry T.M.; Thompson-Schill, Sharon L.

2015-01-01

Understanding events often requires recognizing unique stimuli as alternative, mutually exclusive states of the same persisting object. Using fMRI, we examined the neural mechanisms underlying the representation of object states and object-state changes. We found that subjective ratings of visual dissimilarity between a depicted object and an unseen alternative state of that object predicted the corresponding multivoxel pattern dissimilarity in early visual cortex during an imagery task, while late visual cortex patterns tracked dissimilarity among distinct objects. Early visual cortex pattern dissimilarity for object states in turn predicted the level of activation in an area of left posterior ventrolateral prefrontal cortex (pVLPFC) most responsive to conflict in a separate Stroop color-word interference task, and an area of left ventral posterior parietal cortex (vPPC) implicated in the relational binding of semantic features. We suggest that when visualizing object states, representational content instantiated across early and late visual cortex is modulated by processes in left pVLPFC and left vPPC that support selection and binding, and ultimately event comprehension. PMID:24127425

Prevalence of HLA-B27 in the New Zealand population: effect of age and ethnicity

PubMed Central

2013-01-01

Introduction HLA-B27 genotyping is commonly used to support a diagnosis of ankylosing spondylitis (AS). A recent study has suggested that HLA-B27 may adversely affect longevity. The objectives of this study were to determine, for the first time, the prevalence of HLA-B27 in the New Zealand population, and to test whether HLA-B27 prevalence declines with age. Methods 117 Caucasian controls, 111 New Zealand Māori controls, and 176 AS patients were directly genotyped for HLA-B27 using PCR-SSP. These participants and a further 1103 Caucasian controls were genotyped for the HLA-B27 tagging single nucleotide polymorphisms (SNPs) rs4349859 and rs116488202. All AS patients testing positive for HLA-B27 of New Zealand Māori ancestry underwent high resolution typing to determine sub-allele status. Results HLA-B27 prevalence was 9.2% in New Zealand Caucasian controls and 6.5% in Māori controls. No decline in HLA-B27 prevalence with age was detected in Caucasian controls (p = 0.92). Concordance between HLA-B27 and SNP genotypes was 98.7-99.3% in Caucasians and 76.9-86% in Māori. Of the 14 AS patients of Māori ancestry, 1 was negative for HLA-B27, 10 were positive for HLAB*2705, and 3 positive for HLAB*2704. All cases of genotype discordance were explained by the presence of HLAB*2704. Conclusions HLA-B27 prevalence in New Zealand Caucasians is consistent with that of Northern European populations and did not decline with increasing age. In Māori with AS who were HLA-B27 positive, 76.9% were positive for HLA-B*2705, suggesting that genetic susceptibility to AS in Māori is primarily due to admixture with Caucasians. PMID:24286455

Decoding information about dynamically occluded objects in visual cortex

PubMed Central

Erlikhman, Gennady; Caplovitz, Gideon P.

2016-01-01

During dynamic occlusion, an object passes behind an occluding surface and then later reappears. Even when completely occluded from view, such objects are experienced as continuing to exist or persist behind the occluder, even though they are no longer visible. The contents and neural basis of this persistent representation remain poorly understood. Questions remain as to whether there is information maintained about the object itself (i.e. its shape or identity) or, non-object-specific information such as its position or velocity as it is tracked behind an occluder as well as which areas of visual cortex represent such information. Recent studies have found that early visual cortex is activated by “invisible” objects during visual imagery and by unstimulated regions along the path of apparent motion, suggesting that some properties of dynamically occluded objects may also be neurally represented in early visual cortex. We applied functional magnetic resonance imaging in human subjects to examine the representation of information within visual cortex during dynamic occlusion. For gradually occluded, but not for instantly disappearing objects, there was an increase in activity in early visual cortex (V1, V2, and V3). This activity was spatially-specific, corresponding to the occluded location in the visual field. However, the activity did not encode enough information about object identity to discriminate between different kinds of occluded objects (circles vs. stars) using MVPA. In contrast, object identity could be decoded in spatially-specific subregions of higher-order, topographically organized areas such as ventral, lateral, and temporal occipital areas (VO, LO, and TO) as well as the functionally defined LOC and hMT+. These results suggest that early visual cortex may represent the dynamically occluded object’s position or motion path, while later visual areas represent object-specific information. PMID:27663987

Georgia Power Company, Wansley Steam Electric Generating Plant; Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Wisconsin Public Service, Weston Generating Station; Petition to Object to Issuance of Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Thoroughbred Generating Company, Muhlenberg County, Kentucky; Order Denying Petition For Objection To Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Tennessee Valley Authority, Paradise Fossil Plant; Order Responding Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Spectrophotometric observations of symbiotic stars and related objects

NASA Technical Reports Server (NTRS)

Blair, W. P.; Feibelman, W. A.; Michalitsianos, A. G.; Stencel, R. E.

1983-01-01

Calibrated optical spectrophotometric observations of 16 symbiotic and symbiotic-like objects are presented. The objects observed include Z And, T CrB, CH Cyg, CI Cyg, V1016 Cyg, V1329 Cyg, AG Dra, YY Her, RS Oph, XX Oph, AG Peg, AX Per, CL Sco, HM Sge, AS 289, and M1-2. Integrated emission-line intensities are tabulated for comparison with ultraviolet and infrared data, as well as with previous optical studies. The reddening to each of the objects is derived by assuming that Balmer lines are emitted in their case B recombination ratios. However, the values so derived are often systematically higher than reddening estimates from the ultraviolet 2200 A feature. Comparisons with the available data from other wavelength ranges are noted.

Petition Requesting the Admistrator to Object to Title V Operating Permit Issued to Noranda Alumina

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Sierra Club Petition to Object to Doe Run Buick Mine and Mill Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to the Nucor Steel, St. James Parish, Louisiana Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Order Denying Petition for Objection to Siminole Road Municipal Solid Waste Landfill's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

NYPIRG Petition to Object to Yeshiva University's Albert Einstein College of Medicane Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to Title V Permit for Marcal Paper Mills, Inc., Elmwood Park, NJ

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Sierra Club's Petition to Have the Administrator Object to Caldewll Tank Alliance's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

King Finishing, Order Granting Remanded Issue on Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Oak Creek Power Plant, Oak Creek, Wisconsin Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Salt River Project San Tan Generating Station, Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to the TVA Paradise Fossil Plant, Drakesboro, Kentucky, Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition Requesting the Administartor to Object to Title V Permit for Hu Honua Bioenergy, LLC

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

November 24, 2003 Petition Requesting the Administrator Object to Valero Refining Company's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to the Xcel Energy, Hayden Station, Hayden Colorado, Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Honeywell Engines, Systems and Services, Phoenix, Arizona, Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition Requesting the Administartor Object to Title V Operating Permit for Big River Steel, LLC.

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Response to Petition for EPA to Object to Cash Creek Generation Station's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petititon Requesting the Administrator Object to Title V Permit for Big Brown Steam Electric Station

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Chalmette Refinery, LLC, Notice of Withdrawl of Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Midwest Generation Waukegan Generating Station, Order Denying Petition for Objection to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to Department of Energy's Hanford Site, Richland, Washington, Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

AEP Turk Station, Hempstead County Hunting Club Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to Title V Permit, Georgia Power Bowen Power Station and Six Others

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition for the Administrator to Object to Title V Permit for San Juan Generating Station

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Order Denying Petition for Object to Title V Permit for Louis Dreyfus Agricultural Industries, LLC

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Bats' avoidance of real and virtual objects: implications for the sonar coding of object size.

PubMed

Goerlitz, Holger R; Genzel, Daria; Wiegrebe, Lutz

2012-01-01

Fast movement in complex environments requires the controlled evasion of obstacles. Sonar-based obstacle evasion involves analysing the acoustic features of object-echoes (e.g., echo amplitude) that correlate with this object's physical features (e.g., object size). Here, we investigated sonar-based obstacle evasion in bats emerging in groups from their day roost. Using video-recordings, we first show that the bats evaded a small real object (ultrasonic loudspeaker) despite the familiar flight situation. Secondly, we studied the sonar coding of object size by adding a larger virtual object. The virtual object echo was generated by real-time convolution of the bats' calls with the acoustic impulse response of a large spherical disc and played from the loudspeaker. Contrary to the real object, the virtual object did not elicit evasive flight, despite the spectro-temporal similarity of real and virtual object echoes. Yet, their spatial echo features differ: virtual object echoes lack the spread of angles of incidence from which the echoes of large objects arrive at a bat's ears (sonar aperture). We hypothesise that this mismatch of spectro-temporal and spatial echo features caused the lack of virtual object evasion and suggest that the sonar aperture of object echoscapes contributes to the sonar coding of object size. Copyright © 2011 Elsevier B.V. All rights reserved.

Exploring occupation roles of hospice family caregivers from Māori, Chinese and Tongan ethnic backgrounds living in New Zealand.

PubMed

Angelo, Jennifer; Wilson, Linda

2014-06-01

A major challenge to occupational therapists working in palliative care is determining the best ways to help family caregivers who are caring for family members. The purpose of this study was to explore palliative caregiver occupations among Māori, Chinese and Tongan ethnicities. Six informants participated, one woman and one man from each ethnic group. In each of their homes, informants were asked to discuss what it was like caring for their dying family member. The occupational themes resulting from these interviews were food preparation, spirituality and family gathering. Therapists need to be aware of the differences in how people care for family members within their ethnicity. Implications are that occupational therapists can help families identify activities important to them within the main occupational themes: different types of foods and their preparations, various ways to express spirituality and how families gather together members of their extended family. Further, clinicians need to take on the role of a "not-knowing" but curious health-care provider in order to meet the needs of caregivers. The limitation was the small number of participants who all lived in one geographic area. Future studies should include a wider group of ethnicities. Copyright © 2014 John Wiley & Sons, Ltd.

Two Color Populations of Kuiper Belt and Centaur Objects and the Smaller Orbital Inclinations of Red Centaur Objects

NASA Astrophysics Data System (ADS)

Tegler, S. C.; Romanishin, W.; Consolmagno, G. J.; J., S.

2016-12-01

We present new optical colors for 28 Kuiper Belt objects (KBOs) and 35 Centaur objects measured with the 1.8 m Vatican Advanced Technology Telescope and the 4.3 m Discovery Channel Telescope. By combining these new colors with our previously published colors, we increase the sample size of our survey to 154 objects. Our survey is unique in that the uncertainties in our color measurements are less than half the uncertainties in the color measurements reported by other researchers in the literature. Small uncertainties are essential for discerning between a unimodal and a bimodal distribution of colors for these objects as well as detecting correlations between colors and orbital elements. From our survey, it appears red Centaurs have a broader color distribution than gray Centaurs. We find red Centaurs have a smaller orbital inclination angle distribution than gray Centaurs at the 99.3% confidence level. Furthermore, we find that our entire sample of KBOs and Centaurs exhibits bimodal colors at the 99.4 % confidence level. KBOs and Centaurs with H V > 7.0 have bimodal colors at the 99.96% confidence level and KBOs with H V < 6.0 have bimodal colors at the 96% confidence level.

The foundations of object permanence: does perceived cohesion determine infants' appreciation of the continuous existence of material objects?

PubMed

Cacchione, Trix

2013-09-01

One of the most fundamental achievements in infants' cognitive development is their appreciation that material objects exist permanently in space and time. Recent findings suggest that infants fail to identify fragmented material objects as continuously existing items. Four experiments assessed 8-12-month-old infants' ability to further represent an object that was fragmented into two or more parts. Results suggest that infants successfully trace the spatiotemporal displacement of fragmented objects, but that their processing of size/quantity-related property information may be affected. This suggests that, contrary to recent claims, 8- to 12-month-old infants can and do appreciate the continuity of fragmented objects. Copyright © 2013 Elsevier B.V. All rights reserved.

Relational Resilience in Māori, Pacific, and European Sole Parent Families: From Theory and Research to Social Policy.

PubMed

Waldegrave, Charles; King, Peter; Maniapoto, Maria; Tamasese, Taimalieutu Kiwi; Parsons, Tafaoimalo Loudeen; Sullivan, Ginny

2016-12-01

This study reports findings and policy recommendations from a research project that applied a relational resilience framework to a study of 60 sole parent families in New Zealand, with approximately equal numbers of Māori, Pacific, and European (White) participants. The sole parent families involved were already known to be resilient and the study focused on identifying the relationships and strategies underlying the achievement and maintenance of their resilience. The study was carried out to provide an evidence base for the development and implementation of policies and interventions to both support sole parent families who have achieved resilience and assist those who struggle to do so. The three populations shared many similarities in their pathways to becoming sole parents and the challenges they faced as sole parents. The coping strategies underlying their demonstrated resilience were also broadly similar, but the ways in which they were carried out did vary in a manner that particularly reflected cultural practices in terms of their reliance upon extended family-based support or support from outside the family. The commonalities support the appropriateness of the common conceptual framework used, whereas the differences underline the importance of developing nuanced policy responses that take into account cultural differences between the various populations to which policy initiatives are directed. © 2016 Family Process Institute.

General object recognition is specific: Evidence from novel and familiar objects.

PubMed

Richler, Jennifer J; Wilmer, Jeremy B; Gauthier, Isabel

2017-09-01

object recognition. Copyright © 2017 Elsevier B.V. All rights reserved.

Optical and Near-infrared Spectra of σ Orionis Isolated Planetary-mass Objects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zapatero Osorio, M. R.; Béjar, V. J. S.; Ramírez, K. Peña, E-mail: mosorio@cab.inta-csic.es, E-mail: vbejar@iac.es, E-mail: karla.pena@uantof.cl

We have obtained low-resolution optical (0.7–0.98 μ m) and near-infrared (1.11–1.34 μ m and 0.8–2.5 μ m) spectra of 12 isolated planetary-mass candidates ( J = 18.2–19.9 mag) of the 3 Myr σ Orionis star cluster with the aim of determining the spectroscopic properties of very young, substellar dwarfs and assembling a complete cluster mass function. We have classified our targets by visual comparison with high- and low-gravity standards and by measuring newly defined spectroscopic indices. We derived L0–L4.5 and M9–L2.5 using high- and low-gravity standards, respectively. Our targets reveal clear signposts of youth, thus corroborating their cluster membership andmore » planetary masses (6–13 M {sub Jup}). These observations complete the σ Orionis mass function by spectroscopically confirming the planetary-mass domain to a confidence level of ∼75%. The comparison of our spectra with BT-Settl solar metallicity model atmospheres yields a temperature scale of 2350–1800 K and a low surface gravity of log g ≈ 4.0 [cm s{sup −2}], as would be expected for young planetary-mass objects. We discuss the properties of the cluster’s least-massive population as a function of spectral type. We have also obtained the first optical spectrum of S Ori 70, a T dwarf in the direction of σ Orionis. Our data provide reference optical and near-infrared spectra of very young L dwarfs and a mass function that may be used as templates for future studies of low-mass substellar objects and exoplanets. The extrapolation of the σ Orionis mass function to the solar neighborhood may indicate that isolated planetary-mass objects with temperatures of ∼200–300 K and masses in the interval 6–13 M {sub Jup} may be as numerous as very low-mass stars.« less

New insights on the AU-scale circumstellar structure of FU Orionis

NASA Astrophysics Data System (ADS)

Malbet, F.; Lachaume, R.; Berger, J.-P.; Colavita, M. M.; di Folco, E.; Eisner, J. A.; Lane, B. F.; Millan-Gabet, R.; Ségransan, D.; Traub, W. A.

2005-07-01

We report new near-infrared, long-baseline interferometric observations at the AU scale of the pre-main-sequence star FU Orionis with the PTI, IOTA and VLTI interferometers. This young stellar object has been observed on 42 nights over a period of 6 years from 1998 to 2003. We have obtained 287 independent measurements of the fringe visibility with 6 different baselines ranging from 20 to 110 m in length, in the H and K bands. Our data resolves FU Ori at the AU scale, and provides new constraints at shorter baselines and shorter wavelengths. Our extensive (u,v)-plane coverage, coupled with the published spectral energy distribution data, allows us to test the accretion disk scenario. We find that the most probable explanation for these observations is that FU Ori hosts an active accretion disk whose temperature law is consistent with standard models and with an accretion rate of dot M= (6.3 ± 0.6) × 10-5 (Mstar/M⊙)-1 M⊙ yr-1. We are able to constrain the geometry of the disk, including an inclination of 55-7+5 deg and a position angle of 47-11 0+7 deg. In addition, a 10 percent peak-to-peak oscillation is detected in the data (at the two-sigma level) from the longest baselines, which we interpret as a possible disk hot-spot or companion. The still somewhat limited (u, v) sampling and substantial measurement uncertainty prevent us from constraining the location of the spot with confidence, since many solutions yield a statistically acceptable fit. However, the oscillation in our best data set is best explained with an unresolved spot located at a projected distance of 10 ± 1 AU at the 130 ± 1 deg position angle and with a magnitude difference of Δ K ≈ 3.9 ± 0.2 and Δ H ≈ 3.6 ± 0.2 mag moving away from the center at a rate of 1.2 ± 0.6 AU yr-1. Although this bright spot on the surface of the disk could be tracing some thermal instabilities in the disk, we propose to interpret this spot as the signature of a companion of the central FU Ori system on

Language and memory for object location.

PubMed

Gudde, Harmen B; Coventry, Kenny R; Engelhardt, Paul E

2016-08-01

In three experiments, we investigated the influence of two types of language on memory for object location: demonstratives (this, that) and possessives (my, your). Participants first read instructions containing demonstratives/possessives to place objects at different locations, and then had to recall those object locations (following object removal). Experiments 1 and 2 tested contrasting predictions of two possible accounts of language on object location memory: the Expectation Model (Coventry, Griffiths, & Hamilton, 2014) and the congruence account (Bonfiglioli, Finocchiaro, Gesierich, Rositani, & Vescovi, 2009). In Experiment 3, the role of attention allocation as a possible mechanism was investigated. Results across all three experiments show striking effects of language on object location memory, with the pattern of data supporting the Expectation Model. In this model, the expected location cued by language and the actual location are concatenated leading to (mis)memory for object location, consistent with models of predictive coding (Bar, 2009; Friston, 2003). Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Music psychopathology. V. Objective features of instrumental performance and psychopathology.

PubMed

Steinberg, R; Fani, M; Raith, L

1992-01-01

Mental disease systematically impairs musical expression according to nosologic classification. This was demonstrated with a polarity profile of the instrumental performances of 60 inpatients and 14 controls matched for musical aptitude. Objective performance characteristics such as irregularities and playing faults were analyzed too. No meaningful correlation between these features and psychopathology resulted. This indicates that even in severe psychopathologic alterations performance features, which depend mainly on education and actual training, are not altered in a systematic manner, in contrast to expressive qualities.

Evolution of Regions Containing Antibiotic Resistance Genes in FII-2-FIB-1 ColV-Colla Virulence Plasmids.

PubMed

Moran, Robert A; Hall, Ruth M

2018-05-01

Three ColV virulence plasmids carrying antibiotic resistance genes were assembled from draft genome sequences of commensal ST95, ST131, and ST2705 Escherichia coli isolates from healthy Australians. Plasmids pCERC4, pCERC5, and pCERC9 include almost identical backbones containing FII-2 and FIB-1 replicons and the conserved ColV virulence region with an additional ColIa determinant. Only pCERC5 includes a complete, uninterrupted F-like transfer region and was able to conjugate. pCERC5 and pCERC9 contain Tn1721, carrying the tet(A) tetracycline resistance determinant in the same location, with Tn2 (bla TEM ; ampicillin resistance) interrupting the Tn1721 in pCERC5. pCERC4 has a Tn1721/Tn21 hybrid transposon carrying dfrA5 (trimethoprim resistance) and sul1 (sulfamethoxazole resistance) in a class 1 integron. Four FII-2:FIB-1 ColV-ColIa plasmids in the GenBank nucleotide database have a related transposon in the same position, but an IS26 has reshaped the resistance gene region, deleting 2,069 bp of the integron 3'-CS, including sul1, and serving as a target for IS26 translocatable units containing bla TEM , sul2 and strAB (streptomycin resistance), or aphA1 (kanamycin/neomycin resistance). Another ColV-ColIa plasmid containing a related resistance gene region has lost the FII replicon and acquired a unique transfer region via recombination within the resistance region and at oriT. Eighteen further complete ColV plasmid sequences in GenBank contained FIB-1, but the FII replicons were of three types, FII-24, FII-18, and a variant of FII-36.

Laboratory simulation of photoionized plasma among astronomical compact objects

NASA Astrophysics Data System (ADS)

Fujioka, Shinsuke; Yamamoto, Norimasa; Wang, Feilu; Salzmann, David; Li, Yutong; Rhee, Yong-Joo; Nishimura, Hiroaki; Takabe, Hideaki; Mima, Kunioki

2008-11-01

X-ray line emission with several-keV of photon energy was observed from photoionized accreting clouds, for example CYGNUS X-3 and VELA X-1, those are exposed by hard x-ray continuum from the compact objects, such as neutron stars, black holes, or white dwarfs, although accreting clouds are thermally cold. The x-ray continuum-induced line emission gives a good insight to the accreting clouds. We will present a novel laboratory simulation of the photoionized plasma under well-characterized conditions by using high-power laser facility. Blackbody radiator with 500-eV of temperature, as a miniature of a hot compact object, was created.Silicon (Si) plasma with 30-eV of electron temperature was produced in the vicinity of the 0.5-keV blackbody radiator. Line emissions of lithium- and helium-like Si ions was clearly observed around 2-keV of photon-energy from the thermally cold Si plasma, this result is hardly interpreted without consideration of the photoionization. Atomic kinetics code reveals importance of inner-shell ionization directly caused by incoming hard x-rays.

Object-oriented code SUR for plasma kinetic simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levchenko, V.D.; Sigov, Y.S.

1995-12-31

We have developed a self-consistent simulation code based on object-oriented model of plasma (OOMP) for solving the Vlasov/Poisson (V/P), Vlasov/Maxwell (V/M), Bhatnagar-Gross-Krook (BGK) as well as Fokker-Planck (FP) kinetic equations. The application of an object-oriented approach (OOA) to simulation of plasmas and plasma-like media by means of splitting methods permits to uniformly describe and solve the wide circle of plasma kinetics problems, including those being very complicated: many-dimensional, relativistic, with regard for collisions, specific boundary conditions etc. This paper gives the brief description of possibilities of the SUR code, as a concrete realization of OOMP.

Entergy Louisiana, Little Gypsy Solid Fuel Repowering Project; Petition to Object to the Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Ultramar Refining, Subsidiary of Valero Energy Corporation, Wilmington, California; Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Responses to Orientation Discontinuities in V1 and V2: Physiological Dissociations and Functional Implications

PubMed Central

Purpura, Keith P.; Victor, Jonathan D.

2014-01-01

Segmenting the visual image into objects is a crucial stage of visual processing. Object boundaries are typically associated with differences in luminance, but discontinuities in texture also play an important role. We showed previously that a subpopulation of neurons in V2 in anesthetized macaques responds to orientation discontinuities parallel to their receptive field orientation. Such single-cell responses could be a neurophysiological correlate of texture boundary detection. Neurons in V1, on the other hand, are known to have contextual response modulations such as iso-orientation surround suppression, which also produce responses to orientation discontinuities. Here, we use pseudorandom multiregion grating stimuli of two frame durations (20 and 40 ms) to probe and compare texture boundary responses in V1 and V2 in anesthetized macaque monkeys. In V1, responses to texture boundaries were observed for only the 40 ms frame duration and were independent of the orientation of the texture boundary. However, in transient V2 neurons, responses to such texture boundaries were robust for both frame durations and were stronger for boundaries parallel to the neuron's preferred orientation. The dependence of these processes on stimulus duration and orientation indicates that responses to texture boundaries in V2 arise independently of contextual modulations in V1. In addition, because the responses in transient V2 neurons are sensitive to the orientation of the texture boundary but those of V1 neurons are not, we suggest that V2 responses are the correlate of texture boundary detection, whereas contextual modulation in V1 serves other purposes, possibly related to orientation “pop-out.” PMID:24599456

Examining object recognition and object-in-Place memory in plateau zokors, Eospalax baileyi.

PubMed

Hegab, Ibrahim M; Tan, Yuchen; Wang, Chan; Yao, Baohui; Wang, Haifang; Ji, Weihong; Su, Junhu

2018-01-01

Recognition memory is important for the survival and fitness of subterranean rodents due to the barren underground conditions that require avoiding the burden of higher energy costs or possible conflict with conspecifics. Our study aims to examine the object and object/place recognition memories in plateau zokors (Eospalax baileyi) and test whether their underground life exerts sex-specific differences in memory functions using Novel Object Recognition (NOR) and Object-in-Place (OiP) paradigms. Animals were tested in the NOR with short (10min) and long-term (24h) inter-trial intervals (ITI) and in the OiP for a 30-min ITI between the familiarization and testing sessions. Plateau zokors showed a strong preference for novel objects manifested by a longer exploration time for the novel object after 10min ITI but failed to remember the familiar object when tested after 24h, suggesting a lack of long-term memory. In the OiP test, zokors effectively formed an association between the objects and the place where they were formerly encountered, resulting in a higher duration of exploration to the switched objects. However, both sexes showed equivalent results in exploration time during the NOR and OiP tests, which eliminates the possibility of discovering sex-specific variations in memory performance. Taken together, our study illustrates robust novelty preference and an effective short-term recognition memory without marked sex-specific differences, which might elucidate the dynamics of recognition memory formation and retrieval in plateau zokors. Copyright © 2017 Elsevier B.V. All rights reserved.

Petition Requesting the Administrator Object to Luminant Generating Company's Monticelo Steam Electric Station Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Amended Order Responding to October 2003 Petition Requesting the Administrator Object to Cargill's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Citgo Refining and Chemicals Company, Corpus Christi West, 2007 Petition for Objection to Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Order Responding to 2002 Request for the Administrator to Object to Motiva Enterprises' Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

January 31, 2003 Petition Requesting the Administrator Object to General Chemical Corporation's Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Peition to Object to the Meraux Refinery, Murphy Oil, USA, Meraux, Louisiana, Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to the Ameren Sioux Power Plant, West Alton, Missouri, Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to the Ameren Missouri Labadie Power Plant, Labadie, Missouri Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

2003 Petition Requesting the Administrator Object to the Title V Permit For Dominion Cove Point LNG

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Georgia Pacific West, Toledo Pulp and Paper Operations, Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

BP Exploration (Alaska) Gathering Center #1, Order Denying Petition for Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

January 24, 2003 Petition for the Administrator to Object to Thoroughbred Generating Station's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Order Responding to Petition Requesting the Administrator Object to Title V Permit Issued to Kentucky Syngas

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition Requesting the Administrator Object to Title V Permit for Duke Energy Progress's Richmond County Turbines

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

October 13, 2003 Petition Requesting the Administrator Object to Valero Benicia Asphalt Plant's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to the Cash Creek Generating Station, Henderson County, Kentucky, Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to the Detroit Renewable Power Waste Incinerator, Detroit, Michigan, Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition for the Administrator to Object to Title V Operating Permit Issued to Mettiki Coal, LLC

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Louisiana Generating LLC, Big Cajun II Power Plant, Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to Cargill's Vegetable Oil Mill and Refinery, Gainesville, Georgia, Title V operating permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

State of Vermont Petition to Object to Title V Operating Permit for International Paper Ticonderoga Mill

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition Requesting That the Administrator Object to the Title V Permit for JP Pulliam Power Plant

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition to Object to Consumer Energy's BC Cobb Power Plant, Muskegon, Michigan, Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition Requesting the Administrator Object to the Title V Permit for the Cash Creek Generation Station

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Bioenergy, LLC - Order Partially Granting and Partially Denying Petition for Objection to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Valero's October 28, 2003 Petition Requesting the Administrator Object to Valero's Benicia Refinery's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Onxy Environmental Services, Order Partially Denying and Partially Granting Petition for Object to Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Petition Requesting the Administrator To Object To the Title V Operating Permit For Conocophillips' Rodeo Refinery

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Managing communication tensions and challenges during the end-of-life journey: perspectives of Māori kaumātua and their whānau.

PubMed

Oetzel, John; Simpson, Mary; Berryman, Kay; Iti, Tiwai; Reddy, Rangimahora

2015-01-01

The purpose of this study is to explore the cultural practices and communication tensions perceived among Māori kaumātua (elders) and their whānaunga (extended family) during the end-of-life journey. Further, the study aims to explore the manner in which the tensions are managed. The study was framed by relational dialectics theory and included interviews with 21 kaumātua and focus groups with 39 whānau members. The study identified three cultural practices (dying at home, prayer, and song) that helped to build connection among the family members and also helped to connect the dying person to the spiritual world. Further, four communication tensions were noted: (a) autonomy and connection; (b) conflict and connection; (c) isolation and connection; and (d) balancing the needs of self and other. To manage these tensions, the following strategies were used: (a) coordination conversations; (b) inclusion in decision-making conversations; (c) emotional support within the whānau; and (d) passing on lessons to the next generation.

A Coordinated X-Ray and Optical Campaign of the Nearest Massive Eclipsing Binary, Delta Orionis Aa. I. Overview of the X-Ray Spectrum

NASA Technical Reports Server (NTRS)

Corcoran, M. F.; Nicholas, J. S.; Pablo, H.; Shenar, T.; Pollock, A. M. T.; Waldron, W. L.; Moffat, A. F. J.; Richardson, N. D.; Russell, C. M. P.; Hamaguchi, K.;

The neural representation of objects formed through the spatiotemporal integration of visual transients

PubMed Central

Erlikhman, Gennady; Gurariy, Gennadiy; Mruczek, Ryan E.B.; Caplovitz, Gideon P.

2016-01-01

Oftentimes, objects are only partially and transiently visible as parts of them become occluded during observer or object motion. The visual system can integrate such object fragments across space and time into perceptual wholes or spatiotemporal objects. This integrative and dynamic process may involve both ventral and dorsal visual processing pathways, along which shape and spatial representations are thought to arise. We measured fMRI BOLD response to spatiotemporal objects and used multi-voxel pattern analysis (MVPA) to decode shape information across 20 topographic regions of visual cortex. Object identity could be decoded throughout visual cortex, including intermediate (V3A, V3B, hV4, LO1-2,) and dorsal (TO1-2, and IPS0-1) visual areas. Shape-specific information, therefore, may not be limited to early and ventral visual areas, particularly when it is dynamic and must be integrated. Contrary to the classic view that the representation of objects is the purview of the ventral stream, intermediate and dorsal areas may play a distinct and critical role in the construction of object representations across space and time. PMID:27033688

FERMI Observations of TeV-Selected Active Galactic Nuclei

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2009-12-04

Here, we report on observations of TeV-selected active galactic nuclei (AGNs) made during the first 5.5 months of observations with the Large Area Telescope (LAT) on-board the Fermi Gamma-ray Space Telescope (Fermi). In total, 96 AGNs were selected for study, each being either (1) a source detected at TeV energies (28 sources) or (2) an object that has been studied with TeV instruments and for which an upper limit has been reported (68 objects). The Fermi observations show clear detections of 38 of these TeV-selected objects, of which 21 are joint GeV-TeV sources, and 29 were not in the thirdmore » EGRET catalog. For each of the 38 Fermi-detected sources, spectra and light curves are presented. Most can be described with a power law of spectral index harder than 2.0, with a spectral break generally required to accommodate the TeV measurements. Based on an extrapolation of the Fermi spectrum, we identify sources, not previously detected at TeV energies, which are promising targets for TeV instruments. Finally, evidence for systematic evolution of the γ-ray spectrum with redshift is presented and discussed in the context of interaction with the extragalactic background light.« less

Impact of occult renal impairment on early and late outcomes following coronary artery bypass grafting

PubMed Central

Marui, Akira; Okabayashi, Hitoshi; Komiya, Tatsuhiko; Tanaka, Shiro; Furukawa, Yutaka; Kita, Toru; Kimura, Takeshi; Sakata, Ryuzo

2013-01-01

OBJECTIVES High serum creatinine is considered an independent risk factor for poor outcomes following coronary artery bypass grafting (CABG). However, the impact of occult renal impairment (ORI), defined as an impaired glomerular filtration rate (GFR) with a normal serum creatinine (SCr) level, remains unclear. Thus, we sought to investigate the impact of ORI on outcomes after CABG. METHODS Among patients undergoing their first percutaneous coronary intervention (PCI) or CABG enrolled in the CREDO-Kyoto Registry (a registry of first-time PCI and CABG patients in Japan), 1842 patients with normal SCr levels undergoing CABG were enrolled in the study. Patients were divided into two groups based on preoperative estimated GFR calculated by the Cockcroft–Gault equation: 1339 patients with estimated GFR of ≥60 ml/min/1.73 m2 (normal group) and 503 with estimated GFR of <60 ml/min/1.73 m2 (ORI group). RESULTS Preoperative estimated GFR differed between the groups (51.3 ± 6.6 vs 85.8 ± 23.0 ml/min/1.73 m2, P < 0.01). ORI was associated with high in-hospital mortality (3.2 vs 1.0%, P < 0.01) and need for dialysis (2.0 vs 0.2%, P < 0.01). In terms of long-term outcomes, ORI was associated with high mortality compared with the normal (hazard ratio [95% confidence interval]: 1.72 [1.16–2.54], P < 0.01) and high incidence of composite cardiovascular events (death, stroke or myocardial infarction: 1.53 [1.16–2.02], P < 0.01). CONCLUSIONS ORI was an independent risk factor for early and late death as well as cardiovascular events in patients undergoing CABG with normal SCr levels. A more accurate evaluation of renal function through a combination of SCr and estimated GFR is needed in patients with normal SCr levels. PMID:23793709

Food Prices and Consumer Demand: Differences across Income Levels and Ethnic Groups

PubMed Central

Ni Mhurchu, Cliona; Eyles, Helen; Schilling, Chris; Yang, Qing; Kaye-Blake, William; Genç, Murat; Blakely, Tony

2013-01-01

Background Targeted food pricing policies may improve population diets. To assess their effects on inequalities, it is important to determine responsiveness to price changes across income levels and ethnic groups. Objective Our goal was to estimate price elasticity (PE) values for major commonly consumed food groups in New Zealand, by income and ethnicity. PE values represent percentage change in demand associated with 1% change in price of that good (own-PE) or another good (cross-PE). Design We used food expenditure data from national household economic surveys in 2007/08 and 2009/10 and Food Price Index data from 2007 and 2010. Adopting an Almost Ideal Demand System approach, own-PE and cross-PE estimates were derived for 24 food categories, household income quintiles, and two ethnic groups (Māori and non-Māori). Results Own-PE estimates (with two exceptions) ranged from −0.44 to −1.78. Cross-PE estimates were generally small; only 31% of absolute values were greater than 0.10. Excluding the outlier ‘energy drinks’, nine of 23 food groups had significantly stronger own-PEs for the lowest versus highest income quintiles (average regression-based difference across food groups −0.30 (95% CI −0.62 to 0.02)). Six own-PEs were significantly stronger among Māori; the average difference for Māori: non-Māori across food groups was −0.26 (95% CI −0.52 to 0.00). Conclusions Food pricing policies have potential to improve population diets. The greater sensitivity of low-income households and Māori to price changes suggests the beneficial effects of such policies on health would be greatest for these groups. PMID:24098408

The emerging causal understanding of institutional objects.

PubMed

Noyes, Alexander; Keil, Frank C; Dunham, Yarrow

2018-01-01

Institutional objects, such as money, drivers' licenses, and borders, have functions because of their social roles rather than their immediate physical properties. These objects are causally different than standard artifacts (e.g. hammers, chairs, and cars), sharing more commonality with other social roles. Thus, they inform psychological theories of human-made objects as well as children's emerging understanding of social reality. We examined whether children (N=180, ages 4-9) differentiate institutional objects from standard artifacts. Specifically, we examine whether children understand that mutual intentions (i.e., the intentions of a social collective) underlie the functional affordances of institutional objects in ways that they do not for standard artifacts. We find that young children assimilate institutional objects into their intuitive theories of standard artifacts; children begin to differentiate between the domains in the elementary school years. Published by Elsevier B.V.

Resolving the inner disk of UX Orionis

NASA Astrophysics Data System (ADS)

Kreplin, A.; Madlener, D.; Chen, L.; Weigelt, G.; Kraus, S.; Grinin, V.; Tambovtseva, L.; Kishimoto, M.

2016-05-01

Aims: The cause of the UX Ori variability in some Herbig Ae/Be stars is still a matter of debate. Detailed studies of the circumstellar environment of UX Ori objects (UXORs) are required to test the hypothesis that the observed drop in photometry might be related to obscuration events. Methods: Using near- and mid-infrared interferometric AMBER and MIDI observations, we resolved the inner circumstellar disk region around UX Ori. Results: We fitted the K-, H-, and N-band visibilities and the spectral energy distribution (SED) of UX Ori with geometric and parametric disk models. The best-fit K-band geometric model consists of an inclined ring and a halo component. We obtained a ring-fit radius of 0.45 ± 0.07 AU (at a distance of 460 pc), an inclination of 55.6 ± 2.4°, a position angle of the system axis of 127.5 ± 24.5°, and a flux contribution of the over-resolved halo component to the total near-infrared excess of 16.8 ± 4.1%. The best-fit N-band model consists of an elongated Gaussian with a HWHM ~ 5 AU of the semi-major axis and an axis ration of a/b ~ 3.4 (corresponding to an inclination of ~72°). With a parametric disk model, we fitted all near- and mid-infrared visibilities and the SED simultaneously. The model disk starts at an inner radius of 0.46 ± 0.06 AU with an inner rim temperature of 1498 ± 70 K. The disk is seen under an nearly edge-on inclination of 70 ± 5°. This supports any theories that require high-inclination angles to explain obscuration events in the line of sight to the observer, for example, in UX Ori objects where orbiting dust clouds in the disk or disk atmosphere can obscure the central star. Based on observations made with ESO telescopes at Paranal Observatory under program IDs: 090.C-0769, 074.C-0552.

TeV γ-ray fluxes from the long campaigns on Mrk 421 as constraints on the emission of TeV-PeV neutrinos and UHECRs

NASA Astrophysics Data System (ADS)

Fraija, N.; Marinelli, A.

2015-10-01

Long TeV γ-ray campaigns have been carried out to study the spectrum, variability and duty cycle of the BL Lac object Markarian 421. These campaigns have given some evidence of the presence of protons in the jet: (i) Its spectral energy distribution which shows two main peaks; one at low energies (∼1 keV) and the other at high energies (hundreds of GeV), has been described by using synchrotron proton blazar model. (ii) The study of the variability at GeV γ-rays and X-rays has indicated no significant correlation. (iii) TeV γ-ray detections without activity in X-rays, called "orphan flares" have been observed in this object. Recently, The Telescope Array Collaboration reported the arrival of 72 ultra-high-energy cosmic rays with some of them possibly related to the direction of Markarian 421. The IceCube Collaboration reported the detection of 37 extraterrestrial neutrinos in the TeV-PeV energy range collected during three consecutive years. In particular, no neutrino track events were associated with this source. In this paper, we consider the proton-photon interactions to correlate the TeV γ-ray fluxes reported by long campaigns with the neutrino and ultra-high-energy cosmic ray observations around this blazar. Considering the results reported by The IceCube and Telescope Array Collaborations, we found that only from ∼25% to 70% of TeV fluxes described with a power law function with exponential cutoff can come from the proton-photon interactions.